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Sample records for sang-woon choi simonetta

  1. CHOIS: enabling grid technologies for obesity surveillance and control.

    Science.gov (United States)

    Datta, Arun K; Jackson, Victoria; Nandkumar, Radha; Sproat, Jill; Zhu, Weimo; Krahling, Heidi

    2010-01-01

    CHOIS, the Child Health and Obesity Informatics System, is developed using open source portal technology with three-tiered Open Grid Services Architecture, an accepted standard for accessing Grid Computing and other services under Open Grid Collaborating Environments (OGCE). Its web application provides web based forms with 112 different fields to enter data ranging from demographic, height & weight for BMI, to genomic information. Automatic computation of BMI, BMI percentile and the risk of obesity alert are embedded into this system. After successful testing of the prototype, CHOIS is now ready to be used by the Illinois Department of Human Services (DHS) for obesity surveillance. This HIPAA & FERPA compliant secure system, integrating large databases in a high performance grid computing environment, enables school-nurse to collect data on school children and report statistical and surveillance information on BMI to identify those at-risk and obese for obesity prevention and intervention programs.

  2. mTOR-inhibitor treatment of metastatic renal cell carcinoma: contribution of Choi and modified Choi criteria assessed in 2D or 3D to evaluate tumor response

    Energy Technology Data Exchange (ETDEWEB)

    Lamuraglia, M. [Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France); Raslan, S.; Penna, R.R.; Wagner, M. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Elaidi, R.; Oudard, S. [APHP, Oncology Unit, Georges-Pompidou Hospital, Paris (France); Escudier, B. [Gustave-Roussy Institute, Medical Oncology Department, Villejuif (France); Slimane, K. [Novartis Pharma, Rueil-Malmaison (France); Lucidarme, O. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France)

    2016-01-15

    To determine whether 2D or 3D Choi and modified Choi (mChoi) criteria could assess the efficacy of everolimus against metastatic renal cell carcinoma (mRCC). RECIST-1.1, Choi, and mChoi criteria were applied retrospectively to analyse baseline and 2-month contrast-enhanced computed tomography (CECT) images in 48 patients with mRCC enrolled in the everolimus arm of the French randomized double-blind multicentre phase III trial comparing everolimus versus placebo (RECORD-1). The primary endpoint was centrally reviewed progression-free survival (PFS) calculated from the initial RECORD-1 analysis. Mean attenuation was determined for 2D target lesion regions of interest drawn on CECT sections whose largest diameters had been measured, and for the 3D whole target lesion. The median PFS was 5.5 months. The median PFS for everolimus responders defined using 3D mChoi criteria was significantly longer than for non-responders (7.6 versus 5.4 months, respectively), corresponding to a hazard ratio for progression of 0.45 (95 % CI: 0.22-0.92), with respective 1-year survival rates of 31 % and 9 %. No other 2D or 3D imaging criteria at 2 months identified patients who would benefit from everolimus. At 2 months, only 3D mChoi criteria were able to identify mRCC patients with a PFS benefit from everolimus. (orig.)

  3. Study protocol of the CHOiCE trial

    DEFF Research Database (Denmark)

    Nielsen, Mette Tranberg; Bech, Bodil Hammer; Blaakær, Jan;

    2016-01-01

    BACKGROUND: The effectiveness of cervical cancer screening programs is challenged by suboptimal participation and coverage. Offering cervico-vaginal self-sampling for human papillomavirus testing (HPV self-sampling) to non-participants can increase screening participation. However, the effect......-up testing at 30, 60, or 90 days after mail out of the results. DISCUSSION: The CHOiCE trial will provide strong and important evidence allowing us to determine if and how HPV self-sampling can be used to increase participation in cervical cancer screening. This trial therefore has the potential to improve...... varies substantially among studies, especially depending on the approach used to offer HPV self-sampling. The present trial evaluates the effect on participation in an organized screening program of a HPV self-sampling kit mailed directly to the home of the woman or mailed to the woman's home on demand...

  4. Code Optimization for the Choi-Williams Distribution for ELINT Applications

    Science.gov (United States)

    2009-12-01

    PAGES 98 14. SUBJECT TERMS Choi-Williams Distribution, Signal Processing, Algorithm Optimization, C programming , Low Probability of Intercept (LPI...not be useful for the C programming language, but was included in this thesis because it could be useful when developing a hardware solution to these...representation. Since there is no such single operation in the C programming language, to utilize this method would involve masking out the eight-bit

  5. The Dynamic Growth Exhibition and Accumulation of Cadmium of Pak Choi (Brassica campestris L. ssp. chinensis Grown in Contaminated Soils

    Directory of Open Access Journals (Sweden)

    Hung-Yu Lai

    2013-10-01

    Full Text Available The accumulation of heavy metals, especially cadmium (Cd, in leafy vegetables was compared with other vegetables. Pak choi (Brassica campestris L. ssp. chinensis is a leafy vegetable consumed in Taiwan and its safety for consumption after growing in contaminated soils is a public concern. A pot experiment (50 days was conducted to understand the dynamic accumulation of Cd by pak choi grown in artificially contaminated soils. The edible parts of pak choi were sampled and analyzed every 2–3 days. The dry weight (DW of pak choi was an exponential function of leaf length, leaf width, and chlorophyll content. The accumulation of Cd increased when the soil Cd concentration was raised, but was kept at a constant level during different growth stages. Pak choi had a high bioconcentration factor (BCF = ratio of the concentration in the edible parts to that in the soils, at values of 3.5–4.0. The consumption of pak choi grown in soils contaminated at levels used in this study would result in the ingestion of impermissible amounts of Cd and could possibly have harmful effects on health.

  6. Measuring heart rate variability by means of information entropies based on Choi-Williams distribution.

    Science.gov (United States)

    Vallverdú, Montserrat; Clariá, Francesc; Melia, Umberto; Bayés de Luna, Antonio; Caminal, Pere

    2015-08-01

    The Shannon entropy theory was applied to the Choi-Williams time-frequency distribution (CWD) of cardiac time series (RR series) in order to extract entropy information in both time and frequency domains. From this distribution, four indexes were defined: (1) instantaneous partial entropy; (2) spectral partial entropy; (3) instantaneous complete entropy; (4) spectral complete entropy. These indexes were used for analyzing the heart rate variability of ischemic cardiomyopathy patients (ICM) with different sudden cardiac death risk. The results have shown that the values of these indexes tend to decrease, with different proportion, when the severity of pathological condition increases. Statistical differences (p-value < 0.0005) of these indexes were found comparing low risk and high risk of cardiac death during night and between daytime and nighttime periods of ICM patients. Finally, these indexes have demonstrated to be useful tools to quantify the different complex components of the cardiac time series.

  7. Stereoselective uptake and distribution of the chiral neonicotinoid insecticide, Paichongding, in Chinese pak choi (Brassica campestris ssp. chinenesis)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Haiyan; Yang, Zhen; Liu, Ruyang; Fu, Qiuguo; Zhang, Sufen; Cai, Zhiqiang; Li, Juying; Zhao, Xiaojun [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Ye, Qingfu, E-mail: qfye@zju.edu.cn [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Wang, Wei [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Li, Zhong, E-mail: lizhong@ecust.edu.cn [School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)

    2013-11-15

    Highlights: • Absorption of foliar applied Paichongding by pak choi was not stereoselective. • Foliar uptake and downward transport of Paichongding were both found in pak choi. • Enantioselective and epimer-selective root uptake were observed for Paichongding. • Foliage/root uptake showed diastereoselective transport of Paichongding epimers. • The SR and RS are more easily taken up by roots and accumulated in edible parts. -- Abstract: Neonicotinoid chiral insecticidal Paichongding is a promising substitute for the widely used imidacloprid. Four stereoisomers of Paichongding, 5R,7R, 5S,7S, 5S,7R and 5R,7S, were employed in both foliage and roots of Chinese pak choi to investigate their stereoselective uptake and distribution in pak choi. Results showed that after foliar application, no stereoselective absorption into pak-choi plants was observed among the enantiomers. Total absorptions were 35.40% of the applied amount for 5R,7R, 36.66% for 5S,7S, 36.80% for 5S,7R and 38.20% for 5R,7S at 96 HAT. The translocation of the four absorbed stereoisomers within pak choi occurred both acropetally and basipetally and the transport of {sup 14}C from enantiomers 5R,7R and 5S,7S were significantly higher than for 5R,7S and 5S,7R. Significant stereoselective translocation inside plants was observed between Paichongding epimers. Total root uptake reached 16.49–19.85% for 5R,7R and 5S,7S, and 24.57–28.82% for 5S,7R and 5R,7S at 144 HAT. Both enantioselective and diastereoselective root uptake into pak-choi occurred between the four stereoisomers. The 5R,7S and 5S,7R enantiomers were more readily uptaken by the roots than 5R,7R and 5S,7S and accumulated in the edible leaves. These results will help to develop an understanding of Paichongding using only the target-active enantiomer of pesticides.

  8. Effects of Amino Acids Replacing Nitrate on Growth, Nitrate Accumulation, and Macroelement Concentrations in Pak-choi (Brassica chinensis L.)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A hydroponic experiment was carried out to determine the influence of replacing 20% of nitrate-N in nutrient solutions with 20 individual amino acids on growth, nitrate accumulation, and concentrations of nitrogen (N), phosphorus (P), and potassium (K) in pak-choi (Brassica chinensis L.) shoots. When 20% of nitrate-N was replaced with arginine (Arg)compared to the full nitrate treatment, pak-choi shoot fresh and dry weights increased significantly (P ≤ 0.05), but when 20% of nitrate-N was replaced with alanine (Ala), valine (Val), leucine (Leu), isoleucine (Ile), proline (Pro), phenylalanine (Phe), methionine (Met), aspartic acid (Asp), glutamic acid (Glu), lysine (Lys), glycine (Gly), serine (Ser), threonine(Thr), cysteine (Cys), and tyrosine (Tyr), shoot fresh and dry weights decreased significantly (P ≤ 0.05). After replacing 20% of nitrate-N with asparagine (Asn) and glutamine (Gln), shoot fresh and dry weights were unaffected. Compared to the full nitrate treatment, amino acid replacement treatments, except for Cys, Gly, histidine (His), and Arg, significantly reduced (P ≤ 0.05) nitrate concentrations in plant shoots. Except for Cys, Leu, Pro, and Met, total N concentrations in plant tissues of the other amino acid treatments significantly increased (P ≤ 0.05). Amino acids also affected total P and K concentrations, but the effects differed depending on individual amino acids. To improve pak-choi shoot quality, Gln and Asn, due to their insignificant effects on pak-choi growth, their significant reduction in nitrate concentrations, and their increase in macroelement content in plants, may be used to partially replace nitrate-N.

  9. Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group by Methyl Jasmonate

    Directory of Open Access Journals (Sweden)

    Moo Jung Kim

    2017-05-01

    Full Text Available Glucosinolates, their hydrolysis products and primary metabolites were analyzed in five pak choi cultivars to determine the effect of methyl jasmonate (MeJA on metabolite flux from primary metabolites to glucosinolates and their hydrolysis products. Among detected glucosinolates (total 14 glucosinolates; 9 aliphatic, 4 indole and 1 aromatic glucosinolates, indole glucosinolate concentrations (153–229% and their hydrolysis products increased with MeJA treatment. Changes in the total isothiocyanates by MeJA were associated with epithiospecifier protein activity estimated as nitrile formation. Goitrin, a goitrogenic compound, significantly decreased by MeJA treatment in all cultivars. Changes in glucosinolates, especially aliphatic, significantly differed among cultivars. Primary metabolites including amino acids, organic acids and sugars also changed with MeJA treatment in a cultivar-specific manner. A decreased sugar level suggests that they might be a carbon source for secondary metabolite biosynthesis in MeJA-treated pak choi. The result of the present study suggests that MeJA can be an effective agent to elevate indole glucosinolates and their hydrolysis products and to reduce a goitrogenic compound in pak choi. The total glucosinolate concentration was the highest in “Chinese cabbage” in the control group (32.5 µmol/g DW, but indole glucosinolates increased the greatest in “Asian” when treated with MeJA.

  10. Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, N., E-mail: Nicolai.schramm@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Englhart, E., E-mail: Elisabeth.Englhart@gmx.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Schlemmer, M., E-mail: Marcus.Schlemmer@med.uni-muenchen.de [Department of Medicine III, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Hittinger, M., E-mail: Markus.Hittinger@uksh.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Übleis, C., E-mail: Christopher.Uebleis@med.uni-muenchen.de [Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Becker, C.R., E-mail: Christoph.becker@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Reiser, M.F., E-mail: Maximilian.Reiser@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Berger, F., E-mail: Frank.Berger@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany)

    2013-06-15

    Purpose: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). Patients and methods: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan–Meier statistics. Results: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. Conclusion: One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.

  11. Análise de crescimento e produtividade do pak choi cultivado sob diferentes doses de nitrogênio

    Directory of Open Access Journals (Sweden)

    Janaína Dartora

    2013-08-01

    Full Text Available O objetivo deste trabalho foi avaliar a influência de diferentes doses de nitrogênio no crescimento e produtividade do pak choi. O experimento foi conduzido, em cultivo protegido, de outubro a novembro de 2007, em Marechal Cândido Rondon, PR. O delineamento experimental foi de blocos casualizados, com cinco tratamentos (0, 60, 105, 150 e 195 kg ha-1 de N e quatro repetições. O nitrogênio foi aplicado em três diferentes épocas (transplantio, 7 e 14 dias após o transplantio. Foram realizadas cinco coletas das plantas, semanalmente, avaliando-se a produção de massa da matéria seca e área foliar, para obtenção das taxas de crescimento absoluto e relativo, taxa assimilatória líquida, razão de área foliar e área foliar específica. Na colheita, foram avaliados altura da planta, diâmetro e matéria fresca da parte aérea e produtividade. Incrementos na adubação nitrogenada até a dose de 195 kg ha-1 proporcionam incrementos no crescimento e produtividade do pak choi.

  12. Variation in glucosinolates in pak choi cultivars and various organs at different stages of vegetative growth during the harvest period

    Institute of Scientific and Technical Information of China (English)

    Biao ZHU; Jing YANG; Zhu-jun ZHU

    2013-01-01

    Glucosinolates (GSs) play an important role in plant defense systems and human nutrition.We investigated the content and composition of GSs in the shoots and roots of seven cultivars of pak choi.We found that ‘Si Yue Man’ had the highest total and aliphatic GS contents in the shoots and the highest benzenic GS content in the roots,‘Shanghai Qing’ contained the highest amounts of benzenic and total GS contents in the roots,while ‘Nanjing Zhong Gan Bai’ had the lowest benzenic,indole,and total GS contents in both the shoots and roots.Therefore,the ‘Si Yue Man’ cultivar appears to be a good candidate for future breeding.Variation between the shoots and roots was also examined,and a significant correlation among the total,aliphatic,and some individual GSs was found,which is of value in agricultural breeding.GS concentrations of the leaf,petiole,and root increased dramatically during the period of rapid growth of the dry matter of the plant 10 to 20 d after transplantation,reaching peak values on Day 20 and decreasing on Day 25.We conclude that the pak choi should be harvested and consumed from 20 to 25 d after transplantation to take advantages of the high GS content in the plant.

  13. Glucosinolate Accumulation and Related Gene Expression in Pak Choi (Brassica rapa L. ssp. chinensis var. communis [N. Tsen & S.H. Lee] Hanelt) in Response to Insecticide Application.

    Science.gov (United States)

    Zhu, Biao; Yang, Jing; He, Yong; Zang, Yunxiang; Zhu, Zhujun

    2015-11-11

    Glucosinolates and their breakdown products are well-known for their cancer-chemoprotective functions and biocidal activities against pathogens and generalist herbivores. Insecticides are commonly used in the production of pak choi (Brassica rapa L. ssp. chinensis var. communis [N. Tsen & S.H. Lee] Hanelt). We studied the effects of four commonly used insecticides, namely, β-cypermethrin, acephate, pymetrozine, and imidacloprid, on glucosinolate metabolism in pak choi. All insecticides significantly increased both the transcription of glucosinolate biosynthetic genes and the aliphatic and total glucosinolate accumulations in pak choi. β-Cypermethrin and acephate caused gradual and continuous up-regulation of gene expression from 0.5 to 24 h after treatment, whereas pymetrozine and imidacloprid did so more rapidly, reaching a peak at 1 h and returning to normal at 3 h. Our findings indicate that the four insecticides affect glucosinolate metabolism in pak choi plants to various degrees and suggest that glucosinolates may be involved in plant insecticide metabolism.

  14. Phytoavailability of cadmium (Cd) to Pak choi (Brassica chinensis L.) grown in Chinese soils: a model to evaluate the impact of soil Cd pollution on potential dietary toxicity.

    Science.gov (United States)

    Rafiq, Muhammad Tariq; Aziz, Rukhsanda; Yang, Xiaoe; Xiao, Wendan; Stoffella, Peter J; Saghir, Aamir; Azam, Muhammad; Li, Tingqiang

    2014-01-01

    Food chain contamination by soil cadmium (Cd) through vegetable consumption poses a threat to human health. Therefore, an understanding is needed on the relationship between the phytoavailability of Cd in soils and its uptake in edible tissues of vegetables. The purpose of this study was to establish soil Cd thresholds of representative Chinese soils based on dietary toxicity to humans and develop a model to evaluate the phytoavailability of Cd to Pak choi (Brassica chinensis L.) based on soil properties. Mehlich-3 extractable Cd thresholds were more suitable for Stagnic Anthrosols, Calcareous, Ustic Cambosols, Typic Haplustalfs, Udic Ferrisols and Periudic Argosols with values of 0.30, 0.25, 0.18, 0.16, 0.15 and 0.03 mg kg-1, respectively, while total Cd is adequate threshold for Mollisols with a value of 0.86 mg kg-1. A stepwise regression model indicated that Cd phytoavailability to Pak choi was significantly influenced by soil pH, organic matter, total Zinc and Cd concentrations in soil. Therefore, since Cd accumulation in Pak choi varied with soil characteristics, they should be considered while assessing the environmental quality of soils to ensure the hygienically safe food production.

  15. Produção de repolho branco chinês (pak choi sob proteção com "não tecido" de polipropileno Yield of pak choi crop under non woven polypropylene

    Directory of Open Access Journals (Sweden)

    Marie Y. Reghin

    2002-06-01

    Full Text Available O cultivo do repolho branco chinês (pak choi (Brassica campestris var. chinensis foi avaliado nas condições de inverno dos Campos Gerais (PR, sob proteção, com "não tecido" de polipropileno branco, também conhecido como agrotêxtil, nas gramaturas de 17 e 25 g/m², comparado com o cultivo sem proteção. Os híbridos usados foram Canton e Chouyou com semeadura em bandejas de poliestireno expandido em 11/05/00 e transplante no estádio de 4-5 folhas definitivas, em 23/06/00. O delineamento experimental foi de blocos casualizados com 5 repetições, tendo os tratamentos seguido esquema fatorial 3x2. Cada parcela teve 36 plantas distribuídas no espaçamento 0,30 x 0,30m. Após o transplante, nas parcelas respectivas, as plantas foram cobertas com o agrotêxtil como uma manta flutuante. As avaliações na colheita, realizada de acordo com a maturidade das plantas foram: número de folhas, altura da parte aérea, diâmetro da base, peso de matéria fresca e matéria seca de plantas. A porcentagem de plantas com florescimento prematuro foi avaliada aos 51 dias. No cultivo sem proteção, as plantas do híbrido Canton foram prejudicadas pela geada, apresentando os bordos foliares totalmente queimados, enquanto o híbrido Chouyou não teve nenhum sintoma visual de dano por geada. O agrotêxtil protegeu as plantas contra a geada e contribuiu para o desenvolvimento mais rápido das plantas, possibilitando colheita precoce aos 38 dias do transplante quando usou-se gramatura de 25 g/m² e aos 42 dias na de 17 g/m². No cultivo sem proteção, a colheita ocorreu somente aos 46 dias. Entre os híbridos, Canton foi mais precoce que Chouyou. No entanto, Canton foi suscetível ao florescimento prematuro na estação de inverno, apresentando algumas plantas com esta ocorrência aos 36 dias do transplante. A proteção com polipropileno promoveu a produção de plantas com qualidade superior do produto observada através das características de maior peso

  16. Measurement of Some Physiological and Biochemical Indexes of the Antisense Fragment of CYP86MF Gene Transgenic Male Sterile Plantlets in Chinese Cabbage-Pak-Choi

    Institute of Scientific and Technical Information of China (English)

    YU Xiao-lin; CAO Jia-shu; DONG De-kun

    2003-01-01

    In order to study the mechanism of the transgenic male sterility induced by the antisense fragment of gene CYP86MF, some physiological and biochemical indexes were compared between the transgenic plantlets of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) and their controls.Results showed that there was significant difference between content of the endogenous hormones in leaves and floral buds. GA3 contents in leaves of the transgenic plantlets of B. campestris L. ssp. chinensis Makino cv.Shanghai-qing and cv. Youqing were reduced by 31.72 and 46.88% respectively as compared with those of their controls, and GA3 contents in floral buds of them were reduced by 62.92 and 80.57 % respectively. In addition, ZT contents in leaves of cv. Shanghai-qing and cv. Youqing were reduced by 11.81 and 181.20%respectively as compared with those of their controls and those in floral buds were reduced by 105.94 and 128.75% respectively. But, ABA content in transgenic plantlets was significantly higher than that in nontransgenic plantlets. However, differences among respiratory rate and cyanide-resistant respiratory rate, the photosynthesic rate and the content of total flavones in floral buds were not significant. In this study, the results indicated that the gene CYP86MF might be one of the key functional genes to control fertility of Chinese cabbage.

  17. High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate.

    Science.gov (United States)

    Wiesner, Melanie; Schreiner, Monika; Glatt, Hansruedi

    2014-05-01

    Cruciferous vegetables have the reputation to protect against cancer, an effect attributed to glucosinolates (GLS) and their breakdown products. However, some GLS are mutagenic, an activity associated with cancer initiation rather than chemoprevention. We show that juices from steamed pak choi sprouts are strongly mutagenic in Salmonella typhimurium TA100 upon addition of fresh myrosinase. Growth of the plants in the presence of methyl jasmonate, a hormone eliciting defence factors, led to 20-fold enhanced mutagenic activity. The level of 1-methoxy-3-indolylmethyl (1-MIM)-GLS was similarly increased, whereas those of other GLS were only elevated 0.8- to 3.2-fold. 1-MIM-GLS is a potent mutagen, whose activity is further enhanced by human sulphotransferase 1A1 (hSULT1A1), an activation not observed with other GLS. The mutagenicity of the pak choi juices was increased 20-fold in bacteria expressing hSULT1A1. A tiny level of juice from elicitated sprouts, 0.04% in the mutagenicity assay, was sufficient to double the number of revertants above the spontaneous level. We conclude that pak choi juice is mutagenic, an activity that can be strongly affected by the growth conditions. It is owed essentially to a single component, 1-MIM-GLS. We recommend using cultivars, growth conditions and/or food preparations that keep the level of this GLS congener low.

  18. EEG-Based Brain-Computer Interface for Decoding Motor Imagery Tasks within the Same Hand Using Choi-Williams Time-Frequency Distribution

    Directory of Open Access Journals (Sweden)

    Rami Alazrai

    2017-08-01

    Full Text Available This paper presents an EEG-based brain-computer interface system for classifying eleven motor imagery (MI tasks within the same hand. The proposed system utilizes the Choi-Williams time-frequency distribution (CWD to construct a time-frequency representation (TFR of the EEG signals. The constructed TFR is used to extract five categories of time-frequency features (TFFs. The TFFs are processed using a hierarchical classification model to identify the MI task encapsulated within the EEG signals. To evaluate the performance of the proposed approach, EEG data were recorded for eighteen intact subjects and four amputated subjects while imagining to perform each of the eleven hand MI tasks. Two performance evaluation analyses, namely channel- and TFF-based analyses, are conducted to identify the best subset of EEG channels and the TFFs category, respectively, that enable the highest classification accuracy between the MI tasks. In each evaluation analysis, the hierarchical classification model is trained using two training procedures, namely subject-dependent and subject-independent procedures. These two training procedures quantify the capability of the proposed approach to capture both intra- and inter-personal variations in the EEG signals for different MI tasks within the same hand. The results demonstrate the efficacy of the approach for classifying the MI tasks within the same hand. In particular, the classification accuracies obtained for the intact and amputated subjects are as high as 88 . 8 % and 90 . 2 % , respectively, for the subject-dependent training procedure, and 80 . 8 % and 87 . 8 % , respectively, for the subject-independent training procedure. These results suggest the feasibility of applying the proposed approach to control dexterous prosthetic hands, which can be of great benefit for individuals suffering from hand amputations.

  19. EEG-Based Brain-Computer Interface for Decoding Motor Imagery Tasks within the Same Hand Using Choi-Williams Time-Frequency Distribution

    Science.gov (United States)

    Alwanni, Hisham; Baslan, Yara; Alnuman, Nasim; Daoud, Mohammad I.

    2017-01-01

    This paper presents an EEG-based brain-computer interface system for classifying eleven motor imagery (MI) tasks within the same hand. The proposed system utilizes the Choi-Williams time-frequency distribution (CWD) to construct a time-frequency representation (TFR) of the EEG signals. The constructed TFR is used to extract five categories of time-frequency features (TFFs). The TFFs are processed using a hierarchical classification model to identify the MI task encapsulated within the EEG signals. To evaluate the performance of the proposed approach, EEG data were recorded for eighteen intact subjects and four amputated subjects while imagining to perform each of the eleven hand MI tasks. Two performance evaluation analyses, namely channel- and TFF-based analyses, are conducted to identify the best subset of EEG channels and the TFFs category, respectively, that enable the highest classification accuracy between the MI tasks. In each evaluation analysis, the hierarchical classification model is trained using two training procedures, namely subject-dependent and subject-independent procedures. These two training procedures quantify the capability of the proposed approach to capture both intra- and inter-personal variations in the EEG signals for different MI tasks within the same hand. The results demonstrate the efficacy of the approach for classifying the MI tasks within the same hand. In particular, the classification accuracies obtained for the intact and amputated subjects are as high as 88.8% and 90.2%, respectively, for the subject-dependent training procedure, and 80.8% and 87.8%, respectively, for the subject-independent training procedure. These results suggest the feasibility of applying the proposed approach to control dexterous prosthetic hands, which can be of great benefit for individuals suffering from hand amputations. PMID:28832513

  20. Cloning and Characterization of the Microspore Development-Related Gene BcMF2 in Chinese Cabbage Pak-Choi (Brassica campestris L. ssp. chinensis Makino)

    Institute of Scientific and Technical Information of China (English)

    Yong-Qin WANG; Wan-Zhi YE; Jia-Shu CAO; Xiao-Lin YU; Xun XIANG; Gang LU

    2005-01-01

    For the sake of providing some important information relevant to the study of the molecular mechanism of genic male sterility in plants, gene differential expression in flower buds at different developmental stages, as well as in rosette leaves, florescence leaves, and scapes was analyzed using cDNA amplified fragment length polymorphism (cDNA-AFLP) in the genic male sterile A and fertile B line of Chinese cabbage pak-choi. Following amplification of 125 pairs of primer combinations, 11 differential fragments were obtained, of which eight were from the B line and the other three were from the A line. Of 11 differential fragments, four were verified by Northern hybridization that were expressed preferentially in fertile flower buds. Results of GenBank BLAST showed that one fragment was with unknown function,whereas the other fragments have strong nucleotide sequence similarities with the polygalacturonase (PG)gene, the pectinesterase (PE) gene, and the polygalacturonase inhibitory protein (PGIP4) gene. Only fulllength cDNA from the differential fragment BcMF-A18T16-1 was amplified by rapid amplification of cDNA ends (RACE) and Northern analysis showed that this fragment was expressed only in medium and largesized flower buds of the B line. The full-length cDNA, designated as BcMF2 (Brassica campestris Male Fertile 2), was 1 485 bp long and was composed of a 1 263-bp open reading frame, which had 83% nucleotide similarity to a PG gene from Arabidopsis encoding polygalacturonase. Analysis of the basic structure of the protein revealed that it had one polygalacturonase active site (RVTCGPGHGLSVGS) at 256th site of amino acids and was classified as being a member of family 28 of the glycosyl hydrolases. The role of the BcMF2 gene on microspore development is discussed in the present paper.

  1. Impact of different feedstocks derived biochar amendment with cadmium low uptake affinity cultivar of pak choi (Brassica rapa ssb. chinensis L.) on phytoavoidation of Cd to reduce potential dietary toxicity.

    Science.gov (United States)

    Yasmin Khan, Kiran; Ali, Barkat; Cui, Xiaoqiang; Feng, Ying; Yang, Xiaoe; Joseph Stoffella, Peter

    2017-07-01

    Biochar has become eco-friendly amendment used for phytoavoidation with low cadmium (Cd) accumulating cultivars of crops to ensure food safety in Cd contaminated soils. In this study, biochar with different waste feedstock material were evaluated for their effectiveness on essential trace metals mobility, Cd bioavailability and its accumulation in two contrasting Cd accumulating cultivars of pak choi (Brassica rapa ssp. chinensis L.) grown in Cd contaminated Mollisol soil. A greenhouse experiment was conducted with plants grown in Cd contaminated soil that had been amended with biochar derived from barley straw, tomato green waste, chicken manure, duck manure and swine manure at application rate of 0%, 2.5% and 5.0% (w/w). The results showed that soil pH was significantly increased by all treatments. Biochar increased plant dry biomass, micronutrients bioavailability with significant differences in the Cd sorption capacity, with the effectiveness higher with increasing biochar application rate. However, tomato green waste (TGW) and chicken manure (CM) derived biochar were more effective than the other biochar in reducing Cd mobilization in soil by 35-54% and 26-43% and reduced its accumulation in shoots of pak choi cultivars by 34-76% and 33-72% in low Cd accumulator cultivar and 64-85% and 55-80% in high Cd accumulator cultivar than the control. Overall, results indicate that TGW and CM biochar can efficiently immobilize Cd, thereby reducing bioavailability in Cd contaminated Mollisol soil to ensure food safety. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. 22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    22. August 2013 - Permanent Representative of the Republic of Korea to the United Nations Office and other international organizations in Geneva, Ambassador Extraordinary and Plenipotentiary S. Choi signing the guest book with Director-General R. Heuer; visiting the LHC tunnel with P. Fessia and the CMS experimental cavern with Former Collaboration Spokesperson J. Virdee.

  3. Hans, Choi immunophenotyping and C-MYC genetic features between pediatric and adult diffuse large B-cell lymphoma%儿童与成人弥漫大B细胞淋巴瘤的Hans、Choi免疫分型和C-MYC基因特征

    Institute of Scientific and Technical Information of China (English)

    徐红艳; 黄慧; 杨文萍; 黄传生; 钟梅慧

    2013-01-01

    Objective To explore the difference of Hans,Choi immunophenotyping and C-MYC gene characteristics between pediatric and adult diffuse large B-cell lymphoma.Methods To collect 60 cases of DLBCL clinicopathological data and follow-up,which contained 17 cases of children group,adult group of 43 patients.To observe CD10,BCL-6,MUM1,FOXP1,GCET1 and CD5 protein expression by immunohistochemical SP method and evaluated by Hans and Choi immunophenotyping standard genotyping.To detect C-MYC gene circumstances by interphase fluorescence insituhybridization (FISH).Results 1) Hans typing:the Children DLBCL group of GCB were 11 cases,non-GCB type were 6 cases; the GCB type in the adult DLBCL group were nine cases,non-GCB type were 34 cases.2)Choi typing:the Children DLBCL group of GCB type were 13 cases,ABC type were 4 cases; the adult DLBCL group of GCB type were 13 cases,ABC type were 30 cases (P < 0.01).3) C-MYC gene:The C-MYC gene disruption of children DLBCL were 5 cases; C-MYC gene in 43 adult cases were normal(P <0.01).Conclusions Child DLBCL of GCB-type with better prognosis while but non-GCB-type predict worse prognosis.The C-MYC gene disruption in Children DLBCL was significantly higher than that of adult ones.%目的 探讨弥漫大B细胞淋巴瘤(DLBCL)各年龄组的Hans、Choi免疫分型及C-MYC基因特征.方法 收集60例DLBCL临床病理资料并进行随访,其中儿童组17例、成人组43例.用免疫组化SP法观察CD10、BCL-6、MUM1、FOXP1、GCET1及CD5蛋白表达,根据Hans及Choi免疫分型标准分型;用间期荧光原位杂交法检测C-MYC 基因.结果 1)Hans分型:儿童DLBCL组GCB型11例,non-GCB型6例;成人组DLBCL中GCB型9例,non-GCB型34例(P<0.05).2) Choi分型:儿童DLBCL组GCB型13例,ABC型4例;成人DLBCL组GCB型13例,ABC型30例(P<0.01).3) C-MYC基因:儿童组DLBCL中C-MYC基因断裂6例;成人组DLBCL中C-MYC基因正常43例(P<0.01).结论 儿童DLBCL以GCB型为主,预后较好;成人DLBCL以non-GCB

  4. 76 FR 4939 - John M. Chois; Decision and Order

    Science.gov (United States)

    2011-01-27

    ... suspension of Registrant's license to practice medicine. Id. The Order thus alleged that Registrant is... address of Advanced Aesthetics, 7425 Conroy Road, Orlando, Florida 32835. His registration does not expire.... Registrant's license to practice medicine remains suspended as of the date of this Order. Thus, Registrant...

  5. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Lindsay, K.L

    2014-07-01

    The aim of the study is to explore the dietary intakes of a prominent ethnic minority group of women from Sub-Saharan Africa during pregnancy, in order to identify nutritional issues of concern which may impact on pregnancy outcomes and whether different food based dietary guidelines may be required to meet their needs.

  6. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Lindsay, K.L

    2014-07-01

    The aim of the study is to explore the dietary intakes of a prominent ethnic minority group of women from Sub-Saharan Africa during pregnancy, in order to identify nutritional issues of concern which may impact on pregnancy outcomes and whether different food based dietary guidelines may be required to meet their needs.

  7. Antiproliferation effects of selected Tanzania plants | Choi | African ...

    African Journals Online (AJOL)

    Our screening of indigenous medicinal plants from Tanzania has led to the ... Material and methods: The current study investigates the cytotoxic activity of methanol ... Result 16% of the tested plant extracts showed moderate to strong inhibitory ...

  8. Aras Chois Fharraige, Pairc, An Spidéal, Galway

    LENUS (Irish Health Repository)

    Ward, M

    2010-01-01

    In June and July 2008, two office workers were admitted to a Dublin hospital with Legionnaires\\' disease. Investigations showed that cooling towers in the basement car park were the most likely source of infection. However, positive results from cooling tower samples by polymerase chain reaction (PCR) did not correlate with subsequent culture results. Also, many employees reported Pontiac fever-like morbidity following notification of the second case of Legionnaires\\' disease. In total, 54 employees attended their general practitioner or emergency department with symptoms of Legionnaires\\' disease or Pontiac fever. However, all laboratory tests for Legionnaires\\' disease or Pontiac fever were negative. In this investigation, email was used extensively for active case finding and provision of time information to employees and medical colleagues. We recommend clarification of the role of PCR in the diagnosis of legionellosis and also advocate for a specific laboratory test for the diagnosis of the milder form of legionellosis as in Pontiac fever.

  9. Single seed NIR as a fast method to predict germination ability in Pak Choi

    DEFF Research Database (Denmark)

    Gislum, René; Deleuran, Lise Christina; Olesen, Merete Halkjær;

    2012-01-01

    Single seed NIR has further been tested to determine the applicability for prediction of seed viability in radish (Raphanus sativus L.) seeds and spinach (Spinacia oleracea L.) seeds. The studies show the possibility of using NIR spectroscopy in a seed separating process in the future, provided...

  10. Labile phytochrome and photoperiodic flower induction in Pharbitis nil Chois. The irreversible phytochrome hypothesis

    Directory of Open Access Journals (Sweden)

    Mariusz Cymerski

    2014-01-01

    Full Text Available Seedlings of Pharbitis nil cultivated under non-inductive conditions of white light were subjected to generative induction applying one 16-hour-long period of inductive night. During the eighth hour the night was interrupted with 1 min of red light pulse which completely inhibited the flowering. Treating the plants with KCN blocked the inhibiting effect of red light. Because KCN lowers considerably the rate of destruction of labile Pfd in some plant systems, it seems probable that red light night-break irradiation (without KCN, which blocked the flowering, leads also to the accumulation of unknown Pfd destruction products (irreversible phytochrome. It also suggests that it is not the labile PfrI itself but the products of its irreversible transformation that could be active in the photoperiodic control of flowering.

  11. 9种小白菜种子的醇溶蛋白分析%Studies on the seed gliadin of 9 pak-choi (Brassica chinensis) varieties

    Institute of Scientific and Technical Information of China (English)

    陈彤; 李钧敏; 边才苗; 马国芳

    2003-01-01

    利用酸性聚丙烯酰胺凝胶电泳对9个小白菜品种种子醇溶蛋白进行了分析,结果显示9个小白菜品种的蛋白质电泳图谱具有一定的差异.计算Jaccard系数建立距离矩阵,并通过邻接法进行聚类分析,得出正大抗热青3号与其他品种的关系较远,而苏州青次之.

  12. Myungshin Im, Won-Kee Park, Changsu Choi, Yiseul Jeon, Ji-Hoon Kim (CEOU/SNU), Giseon Baek, Young-Seok Oh, Soojong Pak (Kyunghee Univ.)

    Science.gov (United States)

    Im, Myungshin; Park, Won-Kee; Choi, Changsu; Jeon, Yiseul; Kim, Ji-Hoon; Baek, Giseon; Oh, Young-Seok; Pak, Soojong

    2011-08-01

    On August 30 02:05 UT, we started observations of SN2011fe=PTF11kly (ATel#3581) in grizY and is/iz-bands using CQUEAN on the 2.1m telescope at McDonald observatory, and in zYJHK-bands using UKIRT. SN2011fe is found to have J~11.58 and K~11.55 mag (error~0.05 mag), still brightening in NIR with respect to ATel#3605.

  13. Differential Expression Analysis of Genic Male Sterility A/B Lines in Chinese Cabbage-Pak-Choi(Brassica Campestris ssp. chinensis Makino)

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-qin; CAO Jia-shu; FU Qing-gong; YU Xiao-lin; YE Wan-zhi; XIANG Xun

    2003-01-01

    To determine differential expression of genic male sterility A/B lines in Chinese cabbage-pakchoi (Brassica campestris ssp. chinensis Makino var. communis Teen et Lee), we used the RNA fingerprinting technique, cDNA-AFLP analysis, in different developmental stages and different tissues. While no obvious differential expressions were observed in rosette leaves, florescence leaves, and scapes, some differential expressions were found in alabstrums of A/B lines and among leaves, scapes and alabstrums. We analyzed the alabstrums collected in different developmental stages with 10 primer combinations. We got a unique band between middle size alabstrums and large alabstrums in B line in one of the ten pair primers, and in another one pair, one band reflecting a higher gene-expression level in A line than that in B line was obtained. No unique bands were found with the other primer combinations. The bands reflecting different gene-expression level were confirmed by Northern hybridization. The results indicated that cDNA-AFLP was a suitable tool for studying differential expression of genic male sterility in plants. SDS-polyacrylamide gel electrophoresis patterns of soluble proteins further verified the difference in A/B lines.

  14. Effects of Three Types of Nitrification Inhibitors on Pak-Choi Growth and Soil Property%硝化抑制剂对小白菜生长和土壤性质的影响

    Institute of Scientific and Technical Information of China (English)

    刘静静; 牛庆良; 黄丹枫; 俞文娟

    2014-01-01

    施用硝化抑制剂可有效控制蔬菜硝酸盐积累,施用硝化抑制剂DMPP、土地精和双氰胺可提高小白菜的经济产量、叶面积、净光合速率,降低硝酸盐含量,并对栽培土壤有明显的改良作用.硝化抑制剂对小白菜的硝酸盐积累抑制作用为DMPP>双氰胺>土地精,3种硝化抑制剂在经济产量方面表现为DMPP>DCD>TC,比对照分别提高产量19.32%、14.83%、9.46%.对叶茎鲜重比的影响结果为DCD (84.7%)>DMPP(84.4%)>TC (83.8%)>CK (78.1%).通过对栽培土壤的研究发现硝化抑制剂能显著改良土壤的盐渍化,降低小白菜生长过程中土壤盐离子的含量,提高铵离子在土壤中的含量,抑制土壤耕层硝酸盐的生成.

  15. Emergence

    Directory of Open Access Journals (Sweden)

    Raven John

    2014-07-01

    Full Text Available In this paper I first list a number of areas in which recent research seems to reinforce the need to follow through on activities identified in Simonetta Magari’s article (Magari, Cavaleri 2009. A careful review of research in these areas would lead us into deeply mysterious psychological processes and underline the need to change the most fundamental assumptions on which modern psychology is built. Unfortunately, I am in no position to undertake this review.

  16. Library Users Expect Link Resolvers to Provide Full Text While Librarians Expect Accurate Results. A review of: Wakimoto, Jina Choi, David S. Walker, and Katherine S. Dabbour. “The Myths and Realities of SFX in Academic Libraries.” The Journal of Academic Librarianship 32.2 (Mar. 2006: 127‐ 36.

    Directory of Open Access Journals (Sweden)

    Wendy Furlan

    2006-12-01

    Full Text Available Objective – To determine how successfulthe link resolver, SFX, is in meeting the expectations of library users and librarians.Design – Analysis of an online user survey, library staff focus groups, retrospective analysis of system statistics, and test searches.Setting – Two California State University campus libraries in the United States: Northbridge, with over 31,000 students on campus, and San Marcos, with over 7,300 students on campus.Subjects – A total of 453 online survey responses were submitted from library users, 421 from Northbridge and 32 from SanMarcos. Twenty librarians took part in the focus groups conducted with library staff consisting of 14 of the 23 librarians from Northbridge (2 from technical services and 12 from public services, and 6 of the 10 San Marcos librarians (3 from technical services and 3 from public services. No further information was provided on the characteristics of the subjects.Methods – An online survey was offered to users of the two campus libraries for a two week period in May 2004. The survey consisted of 8 questions, 7 fixed response and 1 free text. Survey distribution was enabled via a different mechanism at each campus. The Northbridge library offered the survey to users via a pop‐up window each time the SFX service was clicked on, while the San Marcos library presented the survey as a link from the library’s home page. Survey responses from both campuses were combined and analysed together. Focus groups were conducted with librarians from each campus library on April 20th, 21st, and 29th, 2004. Librarians attended focus groups only with others from their own campus. Statistics were gathered from each campus’ local SFX system for the 3‐month period from September 14, 2004, to December 14,2004. Statistics from each campus were combined for analysis. The authors also conducted 224 test searches over the 3‐month period from July to September, 2004.Main results – Analysis of the surveys revealed that 80% of users expected to see a full‐text article online when they clicked on the SFX button; 20% expected to rarely or never see one. Responses also gave an almost equal split when users were asked if the SFX service met their expectations with 49.5% saying it did and 50.5% saying it did not. The free text survey question asking for comments on the user’s overall opinion of SFX received 174 responses, 26% of which were positive, 40% negative, and 34% mixed. The primary theme expressed in 49% of all comments received was disappointment in not gaining full‐text access. Thirty‐three percent of other comments were classed as having a general theme, while the remaining 19% of comments regarding the SFX service were categorised with themes of complexity, technical problems, efficiency, or confusion. Results from the librarian focus groups differed between the two campuses. Northbridge librarians had 50% to 85% confidence in the accuracy of SFX and were generally impressed with the service. San Marcos librarians had 60% to 100% confidence that SFX would work, however it was also discovered that several participants had suspicions regarding the accuracy of the system. The SFX usage statistics obtained covered 188,944 individual uses of SFX at both campuses. Statistics showed that 48% of these uses resulted in the user clicking on an option provided, either linking to full‐text, catalogue look‐up, or inter‐library loan form access. Of total occurrences, 39.7% had a link to full‐text displayed; this link was accessed 65.2% of the time. Forty‐seven percent of SFX uses provided a catalogue link (23.8% of which were accessed and 37.9% of uses provided an inter‐library loan link (8.4% of which were accessed. The test searches revealed anomalies to take into account when analysing the SFX usage statistics, including that about 15% of SFX requests display multiple full‐text links. Of the test searches conducted, 22.2% of fulltext availability results ended in either technical or accuracy errors and 8.8% of catalogue look‐ups produced errors. In those cases where errors did not result there were also significant percentages of instances where the library did not have access to the desired resource: 35.3% of searches correctly indicated that no full text was available, and 57.6% correctly linked to the catalogue to show that the periodical was not held locally. While these are correctly generated system results they are still likely to be seen as unfavourable outcomes by users.Conclusion – The results of the study indicated that both library users’ and librarians’ expectations of SFX were slightly higher than their actual experiences. Librarians’ primary concerns related to the need for more accurate results while library users wanted more full text. It was noted that many complaints associated with SFX were likely to actually be problems with systems that SFX links into rather than the software itself. Although imperfect, SFX, and link resolvers in general, are noted to be a vast improvement on the many separate searches required in the past to locate fulltext and undoubtedly user expectations and demand for 100% seamless accessibility will grow.

  17. Developed Matrix inequalities via Positive Multilinear Mappings

    OpenAIRE

    Dehghani, Mahdi; Kian, Mohsen; Seo, Yuki

    2015-01-01

    Utilizing the notion of positive multilinear mappings, we give some matrix inequalities. In particular, Choi--Davis--Jensen and Kantorovich type inequalities including positive multilinear mappings are presented.

  18. Edge-Selectively Functionalized Graphene-Like Platelets as a Co-curing Agent and a Nanoscale Additive to Epoxy Resin

    Science.gov (United States)

    2012-08-12

    as Hot Paper. 8. Kumar, N. A.; Choi, H.-J.; Chang, D. W.; Dai, L.; Baek, J.-B. “Covalent grafting of conducting polyaniline /graphene nanocomposite...12. Choi, H.-J.; Jeon, I.-Y.; Kang, S.-W.; Baek, J.-B. “Electrochemical activity of PANi / PANi -g-MWCNT mixture by simple suspension polymerization

  19. Sensitivity Analysis Based Approaches for Mitigating the Effects of Reducible Interval Input Uncertainty on Single- and Multi-Disciplinary Systems Using Multi-Objective Optimization

    Science.gov (United States)

    2010-01-01

    Du and Choi, 2006; Apley et al., 2006; Li and Azarm, 2008] and Reliability Based Design Optimization ( RBDO ) [Gunawan and Papalambros, 2006; Choi et...assist designers faced with these types of decisions about reducible uncertainty. RBDO approaches have been developed that allow for the inclusion...Youn and Wang, 2008]. Other approaches combine uncertainty reduction mechanisms with RBDO techniques, either through sequentially performing

  20. Cognitive Contours: Recent Work on Cross-Cultural Psychology and Its Relevance for Education

    Science.gov (United States)

    Davies, W. Martin

    2007-01-01

    This paper outlines new work in cross-cultural psychology largely drawn from Nisbett, Choi, and Smith ("Cognition," 65, 15-32, 1997); Nisbett, Peng, Choi, & Norenzayan, "Psychological Review," 108(2), 291-310, 2001; Nisbett, "The Geography of Thought: How Asians and Westerners Think Differently...and Why." New…

  1. B7-H4 as a Target for Breast Cancer Immunotherapy

    Science.gov (United States)

    2013-06-01

    Cell Research 306, 128-141 (2005). [8] G.L. Sica , I.H. Choi, G. Zhu et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity...proliferation through translocating into nucleus. Oncogene (2013). [Epub ahead of print] [11] I.H. Choi, G. Zhu, G.L. Sica et al. Genomic

  2. Tensor networks and graphical calculus for open quantum systems

    CERN Document Server

    Wood, Christopher J; Cory, David G

    2011-01-01

    We develop a graphical calculus for completely positive maps and in doing so cast the theory of open quantum systems into the language of tensor networks. We tailor the theory of tensor networks to pictographically represent the Liouville-superoperator, Choi-matrix, process-matrix, Kraus, and system-environment representations for the evolution of open-system states, to expose how these representations interrelate, and to concisely transform between them. Several of these transformations have succinct depictions as wire bending dualities in our graphical calculus --- reshuffling, vectorization, and the Choi-Jamiolkowski isomorphism. The reshuffling duality between the Choi-matrix and superoperator is bi-directional, while the vectorization and Choi-Jamiolkowski dualities, from the Kraus and system-environment representations to the superoperator and Choi-matrix respectively, are single directional due to the non-uniqueness of the Kraus and system-environment representations. The remaining transformations are ...

  3. Networking. La rete come arte

    DEFF Research Database (Denmark)

    Bazzichelli, Tatiana

    Networking | La rete come arte [book] A reconstruction of the history of artistic networking in Italy, through an analysis of the realities which during the past twenty years have given way to a creative, shared and aware use of technologies, from video to computers, contributing to the formation...... of Italian hacker communities. Book written by Tatiana Bazzichelli, with the preface of Derrick De Kerckhove and the epilogue of the videoartist Simonetta Fadda. Costa & Nolan Ed., Milan, Italy, 2006. English edition (2009): Digital Aesthetics Research Center, Aarhus University, Denmark. networkingart.eu/the-book/...

  4. Study of morphology and crystal growth behaviour of nanoclay-containing biodegradable polymer blend thin films using atomic force microscopy

    CSIR Research Space (South Africa)

    Malwela, T

    2012-04-01

    Full Text Available nanocomposites: in greening the 21st century materials world. Prog Mater Sci 2005; 50: 962?79. [2] Auras R, Harte B, Selke S. An overview of polylactides as packaging materials. Macromol Biosci 2004;4:835?64. [3] Bhatia A, Gupta RK, Bhattacharya SN, Choi HJ...) blend nanocomposites. Polymer 2004; 45:7381?88. [10] Kim HB, Choi JS, Lee CH, Lim ST, John MS, Choi HJ. Polymer blend/organoclay nanocomposite with poly(ethylene oxide) and poly(methyl methacrylate). Euro Polym J 2005;41:679?85. [11] Sinha Ray S...

  5. Hansen Solubility Parameters for Octahedral Oligomeric Silsesquioxanes

    Science.gov (United States)

    2012-08-28

    and thermal and electrical insulation enhancers. The inorganic core is both mechanically robust, resistant to oxidation, and thermally stable, and...Choi, P.; Kavassalis, T. A.; Rudin, A. Estimation of Hansen Solubility Parameters for (Hydroxyethyl)- Cellulose and (Hydroxypropyl) Cellulose through

  6. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 317 ... Working with Groups by Lilly Becker (ed.) Abstract ... Ciara Wynne, Caoimhe Doyle, Rachel Kenny, Eileen Brosnan, John Sharry ... Karmel W. Choi, Melissa H. Watt, Donald Skinner, Seth C. Kalichman, Kathleen J. Sikkema.

  7. FAA Statistical Handbook of Aviation, Calendar Year 1981.

    Science.gov (United States)

    1981-12-31

    Evanston Aviation Chautauqua Airlines, Inc. Executive Aviation, Inc. Choi Aviation, Inc. Far West Airlines Christman Air System Flamenco Airways, Inc...3 2 ......... Flamenco ALways 2 . ... .. .. 2 ron tier Flying Svc. 5 ---.... . -- .... 5 --- Gifford Aviation. Inc. 4 --- .... 4 ---.. Golden

  8. The Navy’s Superior Supplier Incentive Program: Analysis of Supplier Proposed Benefits

    Science.gov (United States)

    2015-12-01

    Information CPR Cost Performance Report CRM Customer Relationship Management CSDR Cost Data Summary Report CSR Contract Status Review... transportation /traffic/shipping and warehousing” (Carter & Choi, 2008, p. 10). Monczka, Handfield, Giunipero, and Patterson (2011) defined supply management as

  9. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  10. Genetics Home Reference: congenital deafness with labyrinthine aplasia, microtia, and microdontia

    Science.gov (United States)

    ... SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of ... Institutes of Health National Library of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, ...

  11. ORIGINAL ARTICLE

    African Journals Online (AJOL)

    User

    cause of nutritional anaemia accounting for almost one million deaths ..... ducted among University of Peshewar students, ... creased incidence of poor nutritional status (Smith,. 2000; Choi ..... Sultan A.H. (2007) Anemia among female college.

  12. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  13. Synergistic Actions of Pyridostigmine Bromide and Insecticides on Muscle and Vascular Nociceptors

    Science.gov (United States)

    2014-01-01

    or increased the absorption of permethrin ( Baynes et al., 2002; Choi et al., 2004; Rose et al., 2005; see also Abu-Qare and Abou-Donia, 2008...widespread pain among veterans following the first Gulf War. Clin J Pain 22, 554-563. Baynes RE, Monteiro-Riviere NA, Riviere JE. Pyridostigmine bromide...Binns et al., 2008; Steele et al., 2011). Some of these agents increase absorption and/or retard catabolism of permethrin ( Baynes et al., 2002; Choi

  14. Identification of Genes Regulating the Development of Breast Cancer

    Science.gov (United States)

    2008-04-01

    Tumor Development Hua Wang, Douglas Teske , Alyssa Tess, Rebecca Kohlhepp, YounJeong Choi, Christina Kendziorski, and Amy Rapaich Moser Cancer Res...Tumor Development Hua Wang, 1,3 Douglas Teske , 1 Alyssa Tess, 1 Rebecca Kohlhepp, 1 YounJeong Choi, 2 Christina Kendziorski, 2 and Amy Rapaich Moser 1... Teske ), and palpable tumors were recorded when first noted and then confirmed at necropsy. The total tumor number was determined at necropsy by noting

  15. Terahertz biomedical science and technology

    CERN Document Server

    Son, Joo-Hiuk

    2014-01-01

    Introduction to Biomedical Studies Using Terahertz WavesJoo-Hiuk SonSection I Terahertz TechnologyTerahertz Sources and DetectorsHyunyong Choi and Joo-Hiuk SonTabletop High-Power Terahertz Pulse Generation TechniquesYun-Shik LeeTerahertz Imaging and Tomography TechniquesHyunyong Choi and Joo-Hiuk SonCompact Solid-State Electronic Terahertz Devices and CircuitsJae-Sung Rieh, Daekeun Yoon, and Jongwon Yun<

  16. Apnea of prematurity: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Picone S

    2014-06-01

    Full Text Available Simonetta Picone, Roberto Aufieri, Piermichele PaolilloDivision of Neonatology and Neonatal Intensive Care, Department of Maternal and Child Health, Casilino General Hospital, Rome, ItalyAbstract: Apnea of prematurity is a developmental disorder that frequently affects preterm infants, especially those with lower gestational age. Even if apnea of prematurity is by definition a self-limiting condition, it can cause serious problems during the hospital stay and can potentially have long-term neurological and cognitive consequences depending on the severity and intensity of the episodes. The diagnosis of apnea of prematurity can be made only after excluding a number of diseases of the preterm infant in which apnea may be an epiphenomenon. Etiological diagnosis is essential for selection of appropriate treatment, which may be nonpharmacological or involve use of drugs.Keywords: apnea of prematurity, idiopathic and secondary apnea, caffeine

  17. Effect of plant species on nitrogen recovery in aquaponics.

    Science.gov (United States)

    Hu, Zhen; Lee, Jae Woo; Chandran, Kartik; Kim, Sungpyo; Brotto, Ariane Coelho; Khanal, Samir Kumar

    2015-01-01

    Nitrogen transformations in aquaponics with different edible plant species, i.e., tomato (Lycopersicon esculentum) and pak choi (Brassica campestris L. subsp. chinensis) were systematically examined and compared. Results showed that nitrogen utilization efficiencies (NUE) of tomato- and pak choi-based aquaponic systems were 41.3% and 34.4%, respectively. The abundance of nitrifying bacteria in tomato-based aquaponics was 4.2-folds higher than that in pak choi-based aquaponics, primarily due to its higher root surface area. In addition, tomato-based aquaponics had better water quality than that of pak choi-based aquaponics. About 1.5-1.9% of nitrogen input were emitted to atmosphere as nitrous oxide (N2O) in tomato- and pak choi-based aquaponic systems, respectively, suggesting that aquaponics is a potential anthropogenic source of N2O emission. Overall, this is the first intensive study that examined the role plant species played in aquaponics, which could provide new strategy in designing and operating an aquaponic system.

  18. Effects of Different Organic Materials and Exogenous Zn on Zn Distribution in Soil

    Directory of Open Access Journals (Sweden)

    HAO Jia-li

    2015-06-01

    Full Text Available A pot experiment with a complete combinatorial design of two factors was conducted to study the effects of different organic materials and different concentrations of exogenous zinc on the soil total zinc, available zinc, zinc forms and zinc content distribution of pak-choi. The results showed that the total zinc, available zinc, and different forms of zinc contents in soil all increased as the concentration of exogenous zinc increased. Both lawn grass and maize straw decreased the total zinc, increased the available zinc and no-residual zinc in soil effectively, and promoted the accumulation of zinc in pak-choi. Chicken manure, pig manure, and cattle manure improved the total zinc, available zinc and no-residual zinc in soil significantly, and enhanced the activity of zinc in soil, and promoted the accumulation of zinc in pak-choi significantly. Peat and weathered coal both increased the organic zinc and residual zinc in soil effectively, decreased the total zinc and available zinc, showing the passivating effect to zinc of soil, and failed to promote the accumulation of zinc in pak-choi. The concentration of zinc in pak-choi root increased as the concentration of exogenous zinc increased.

  19. On the structure of positive maps. II. Low dimensional matrix algebras

    Science.gov (United States)

    Majewski, Władysław A.; Tylec, Tomasz I.

    2013-07-01

    We use a new idea that emerged in the examination of exposed positive maps between matrix algebras to investigate in more detail the differences and similarities between unital positive maps on M2 ({C}) and M3({C}). Our main tool stems from classical Grothendieck theorem on tensor product of Banach spaces and is an older and more general version of Choi-Jamiołkowski isomorphism between positive maps and block positive Choi matrices. It takes into account the correct topology on the latter set that is induced by the uniform topology on positive maps. In this setting, we show that in M2({C}) case a large class of nice positive maps can be generated from the small set of maps represented by self-adjoint unitaries, 2Px with x maximally entangled vector and p⊗ {1} with p rank 1 projector. We indicate problems with passing this result to M3({C}) case. Among similarities, in both M2({C}) and M3({C}) cases any unital positive map represented by self-adjoint unitary is unitarily equivalent to the transposition map. Consequently, we obtain a large family of exposed maps. Furthermore, for M3({C}) there appear new non-trivial class of maps represented by Choi matrices with square equal to a projector. We examine this case. We also investigate a convex structure of the Choi map, the first example of non-decomposable map. As a result the nature of the Choi map will be explained.

  20. Dual-Energy CT in Patients Treated with Anti-Angiogenic Agents for Non-Small Cell Lung Cancer: New Method of Monitoring Tumor Response?

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yoo Na; Lee, Ho Yun; Lee, Kyung Soo; Chung, Myung Jin; Ahn, Myung Ju; Park, Keun Chil; Kim, Tae Sung; Yi, Chin A [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Seo, Joon Beom [Dept. of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2012-11-15

    To evaluate tumor responses in patients treated with anti-angiogenic agents for non-small cell lung cancer (NSCLC) by assessing intratumoral changes using a dual-energy CT (DECT) (based on Choi's criteria) and to compare it to traditional Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Ten NSCLC patients treated with bevacizumab underwent DECT. Tumor responses to anti-angiogenic therapy were assessed and compared with the baseline CT results using both RECIST (size changes only) and Choi's criteria (reflecting net tumor enhancement). Kappa statistics was used to evaluate agreements between tumor responses assessed by RECIST and Choi's criteria. The weighted {kappa} value for the comparison of tumor responses between the RECIST and Choi's criteria was 0.72. Of 31 target lesions (21 solid nodules, 8 lymph nodes, and two ground-glass opacity nodules [GGNs]), five lesions (16%) showed discordant responses between RECIST and Choi's criteria. Iodine-enhanced images allowed for a distinction between tumor enhancement and hemorrhagic response (detected in 14% [4 of 29, excluding GGNs] of target lesions on virtual nonenhanced images). DECT may serve as a useful tool for response evaluation after anti-angiogenic treatment in NSCLC patients by providing information on the net enhancement of target lesions without obtaining non-enhanced images.

  1. IPD-Work consortium

    DEFF Research Database (Denmark)

    Kivimäki, Mika; Singh-Manoux, Archana; Virtanen, Marianna

    2015-01-01

    to advance research on associations between work-related psychosocial risk factors and health; (ii) demonstrate as unfounded Choi et al's assertion that IPD-Work has underestimated associations between job strain and health endpoints; these include the dichotomous measurement of job strain, potential......Established in 2008 and comprising over 60 researchers, the IPD-Work (individual-participant data meta-analysis in working populations) consortium is a collaborative research project that uses pre-defined meta-analyses of individual-participant data from multiple cohort studies representing a range......-Work's findings have also generated disagreement as they challenge the importance of job strain as a major target for coronary heart disease (CHD) prevention, this is reflected in the critical discussion paper by Choi et al (1). In this invited reply to Choi et al, we aim to (i) describe how IPD-Work seeks...

  2. Differential expression of salt tolerance related genes in Brassica campestris L. ssp. chinensis (L.) Makino var. communis Tsen et Lee

    Institute of Scientific and Technical Information of China (English)

    Yang QIU; Xi-xiang LI; Hai-ying ZHI; Di SHEN; Peng LU

    2009-01-01

    We examined salt tolerance responsive genes in Pak-choi under salt stress and analyze their potential function. The mRNA differential display was used to screen the transcript derived fragments (TDFs) related to salinity tolerance in tolerant and moderately tolerant Pak-choi germplasm. Seventy-eight primer combinations generated 101 differential cDNA fragments, which were divided into 10 expression types. Seven cDNA sequences (GenBank accession Nos. DQ006915-DQ006921) obtained and sequenced were highly homologous to some known expression genes or the genes related to the signaling pathways in plants under different abiotic stress.

  3. Light-Hole and Heavy-Hole Transitions for High-Temperature Long-Wavelength Infrared Detection

    Science.gov (United States)

    2010-01-01

    Z. R. Wasilewski , K. K. Choi, P. Wijewarnasuriya Georgia State University Office of Sponsored Programs Georgia State University Research Foundation...Y. F. Lao,1 P. K. D. D. P. Pitigala,1 A. G. U. Perera,1,a H. C. Liu,2 M. Buchanan,2 Z. R. Wasilewski ,2 K. K. Choi,3 and P. Wijewarnasuriya3...89, 131118 2006. 2P. V. V. Jayaweera, S. G. Matsik, A. G. U. Perera, H. C. Liu, M. Buchanan, and Z. R. Wasilewski , Appl. Phys. Lett. 93, 021105

  4. Reference: 117 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available mes (Phys) act as red and far-red light (Pfr) photoreceptors to mediate light sig...ination in Arabidopsis thaliana. 11 3045-58 15486102 2004 Nov The Plant cell Choi Giltsu|Kang Changwon|Kim Jeong-Il|Kim Jonghyun|Oh Eunkyoo|Park Eunae

  5. Karyotype variation and conservation in morphotypes of non-heading Chinese cabbage

    NARCIS (Netherlands)

    Zheng, Jin Shuang; Sun, Cheng Zhen; Xiao, Dong; Zhang, Shu Ning; Bonnema, Guusje; Hou, Xi Lin

    2015-01-01

    Non-heading Chinese cabbage encompasses a wide diversity of morphotypes, like the well-known Pak-choi, Wu ta cai, Cai xin, Tai cai, and Fen nei cai. Despite recent developments in re-sequencing which results in the detection of SNPs, insertions, deletions and copy number variants, there has been

  6. Additive role of attapulgite nanoclay on carbonyl iron-based magnetorheological suspension

    CSIR Research Space (South Africa)

    Chae, HS

    2014-09-01

    Full Text Available -1 Colloid Polym Sci DOI 10.1007/s00396-014-3389-3 Additive role of attapulgite nanoclay on carbonyl iron- based magnetorheological suspension Hyun Sik Chae1, Shang Hao Piao1, Arjun Maity2 and Hyoung Jin Choi1 1Department of Polymer Science...

  7. Rheology of organoclay suspension

    CSIR Research Space (South Africa)

    Hato, MJ

    2011-05-01

    Full Text Available -1 Colloid & Polymer Science Volume 289, Number 10, 1119-1125, DOI: 10.1007/s00396-011-2438-4 Rheology of organoclay suspension Mpitloane Joseph Hato, Ke Zhang, Suprakas Sinha Ray and Hyoung Jin Choi Abstract We have studied the rheological...

  8. Neutraliseeriv valge kuup / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2007-01-01

    XIV Tallinna graafikatriennaal "Poliitiline/Poeetiline" Kumu Kunstimuuseumis kuni 25. XI. Peapreemia pälvis Oscar Munose videoinstallatsioon "Memoriaali projekt", Eesti Panga preemia Haemin Choi. Poliitilisest kunstist. The Elfriede Jelinek School of the English Language'i teosest "Tooda või sure" (Sirp, 2007, 9. XI, lk. 24)

  9. Spectral conditions for positive maps and entanglement witnesses

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2011-03-01

    We provide partial classification of entanglement witnesses and positive maps which is based on a family of spectral conditions. Interestingly many well known examples of positive maps (e.g. transposition, reduction map, the family of Choi maps) belong to the class constructed via spectral conditions.

  10. Geometry of quantum states: New construction of positive maps

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2009-06-01

    We provide a new class of positive maps in matrix algebras. The construction is based on the family of balls living in the space of density matrices of n-level quantum system. This class generalizes the celebrated Choi map and provide a wide family of entanglement witnesses which define a basic tool for analyzing quantum entanglement.

  11. Geometry of quantum states: New construction of positive maps

    Energy Technology Data Exchange (ETDEWEB)

    Chruscinski, Dariusz, E-mail: darch@fizyka.umk.p [Institute of Physics, Nicolaus Copernicus University, Grudziadzka 5/7, 87-100 Torun (Poland); Kossakowski, Andrzej [Institute of Physics, Nicolaus Copernicus University, Grudziadzka 5/7, 87-100 Torun (Poland)

    2009-06-22

    We provide a new class of positive maps in matrix algebras. The construction is based on the family of balls living in the space of density matrices of n-level quantum system. This class generalizes the celebrated Choi map and provide a wide family of entanglement witnesses which define a basic tool for analyzing quantum entanglement.

  12. On the structure of entanglement witnesses and new class of positive indecomposable maps

    OpenAIRE

    Chruściński, Dariusz; Kossakowski, Andrzej

    2006-01-01

    We construct a new class of positive indecomposable maps in the algebra of 'd x d' complex matrices. Each map is uniquely characterized by a cyclic bistochastic matrix. This class generalizes a Choi map for d=3. It provides a new reach family of indecomposable entanglement witnesses which define important tool for investigating quantum entanglement.

  13. Vaata mulle näkku: mu nimi on Oleks Võinud Olla / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    Tallinna Fotokuu raames Kumu Kunstimuuseumis rahvusvaheline kaamerakunsti näitus "Teisele poole" 7.10.2011-08.01.2012, kuraator Adam Budak Osaleb 19 kunstnikku, neist tutvustatakse: John Baldessari (California), Sunah Choi (Korea), Haris Epaminonda (Küpros), Helena Almeida (Portugal), Elad Lassry (Iisrael), Alexandre Singh (Prantsusmaa)

  14. Patient satisfaction and amenorrhea rate after endometrial ablation by ThermaChoice III or NovaSure: a retrospective cohort study

    NARCIS (Netherlands)

    Muller, I.; Palen, van der J.A.M.; Massop-Helmink, D.; Vos-de Bruin, R.; Sikkema, J.M.

    2015-01-01

    Heavy menstrual bleeding poses an important health problem, which can be managed, besides other treatments, with endometrial ablation. Nowadays, the bipolar radio frequency device (NovaSure) is the most commonly used device for endometrial ablation, followed by the thermal balloon device (ThermaChoi

  15. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2012-04-01

    satisfaction with life scale. Journal of Personality Assessment, 49, 71-75. Diener, E., Wirtz, D., Tov, W., Kim- Prieto , C., Choi, D., Oishi, S., & Biswas... Francisco , CA: Jossey-Bass. Seligman, M. E. P., Steen, T. A., Park, N., & Peterson, C. (2005). Positive psychology progress: Empirical validation of

  16. Reference: RHERPATEXPA7 [PLACE

    Lifescience Database Archive (English)

    Full Text Available ional Conservation of a Root Hair Cell-Specific cis-Element in Angiosperms with Different Root Hair Distribution Patterns. Plant Cell. 18:2958-2970 (2006) PubMed: 17098810 ... ...RHERPATEXPA7 Kim DW, Lee SH, Choi SB, Won SK, Heo YK, Cho M, Park YI, Cho HT. Funct

  17. Karyotype variation and conservation in morphotypes of non-heading Chinese cabbage

    NARCIS (Netherlands)

    Zheng, Jin Shuang; Sun, Cheng Zhen; Xiao, Dong; Zhang, Shu Ning; Bonnema, Guusje; Hou, Xi Lin

    2015-01-01

    Non-heading Chinese cabbage encompasses a wide diversity of morphotypes, like the well-known Pak-choi, Wu ta cai, Cai xin, Tai cai, and Fen nei cai. Despite recent developments in re-sequencing which results in the detection of SNPs, insertions, deletions and copy number variants, there has been

  18. Teisel pool fotot : üleval 70 tööd / Ragne Nukk

    Index Scriptorium Estoniae

    Nukk, Ragne, 1984-

    2011-01-01

    Rahvusvaheline fotonäitus "Teisele poole" Kumu Kunstimuuseumis 8. jaanuarini 2012, kuraator Adam Budak. Eksponeeritakse kollaaže, fotodest valmistatud skulptuure, videosid, fotosid, installatsioone. Lühidalt portugali kunstniku Helena Almeida, sakslase Stefan Burgeri, korea kunstniku Sunah Choi, ameeriklase Marlo Pascuali töödest. Näitus toimub Tallinna fotokuu raames

  19. Inducible secretion of phytate-degrading enzymes from bacteria ...

    African Journals Online (AJOL)

    aghomotsegin

    2015-02-04

    Feb 4, 2015 ... (Choi et al., 2001), Bacillus subtilis (Powar and Jagannathan,1982) ... The DNA from Bacillus megaterium was isolated in the 60th h at 37°C, pH ... Carbon source and Yeast extract as Nitrogen source) and was identified as B.

  20. Vaata mulle näkku: mu nimi on Oleks Võinud Olla / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    Tallinna Fotokuu raames Kumu Kunstimuuseumis rahvusvaheline kaamerakunsti näitus "Teisele poole" 7.10.2011-08.01.2012, kuraator Adam Budak Osaleb 19 kunstnikku, neist tutvustatakse: John Baldessari (California), Sunah Choi (Korea), Haris Epaminonda (Küpros), Helena Almeida (Portugal), Elad Lassry (Iisrael), Alexandre Singh (Prantsusmaa)

  1. Toxicity Comparison of Eight Repellents Against Four Species of Female Mosquitoes

    Science.gov (United States)

    2009-01-01

    ACKNOWLEDGMENTS We thank S. M. Valles and M.-Y. Choi (USDA-ARS) for critical reviews of the manu- script. We also thank Lynn Jefferson, Nathan Newlon, William Reid...Rosales C, Gatica M, Klein RE. 1994. Effects of permethrin-impregnated bed nets on malaria vectors of northern Guatemala . Bull Pan Am Health Organ 28:112

  2. Invited Reaction: Influences of Formal Learning, Personal Learning Orientation, and Supportive Learning Environment on Informal Learning

    Science.gov (United States)

    Cseh, Maria; Manikoth, Nisha N.

    2011-01-01

    As the authors of the preceding article (Choi and Jacobs, 2011) have noted, the workplace learning literature shows evidence of the complementary and integrated nature of formal and informal learning in the development of employee competencies. The importance of supportive learning environments in the workplace and of employees' personal learning…

  3. Disease: H00324 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available rview and immune responses. Microbes Infect 3:11-21 (2001) PMID:21458586 (descripti...a ICD-10: A75.3 MeSH: D012612 PMID:11226850 (description, env_factor) Seong SY, Choi MS, Kim IS Orientia tsutsugamushi infection: ove

  4. Effects of Carbohydrate Ingestion and Carbohydrate Mouth Rinse on Repeat Sprint Performance.

    Science.gov (United States)

    Krings, Ben M; Peterson, Timothy J; Shepherd, Brandon D; McAllister, Matthew J; Smith, JohnEric W

    2017-06-01

    The purpose of this investigation was to examine to the influence of carbohydrate ingestion (CHOI) and carbohydrate mouth rinse (CHOR) on acute repeat maximal sprint performance. Fourteen healthy males (age: 21.7 ± 1.8 years, mass: 82.3 ± 12.3 kg) completed a total of five 15-s maximal repeat sprints on a cycle ergometer against 0.075 kg ・ kg(-1) body mass each separated by 4 min of active recovery. Subjects completed four experimental trials and were randomly assigned one of four treatments: (1) CHOI, (2) CHOR, (3) placebo mouth rinse (PLAR), (4) placebo ingestion (PLAI). Subjects rinsed or ingested six 50 mL 10% CHO solutions throughout each trial. Performance variables measured included rating of perceived exertion, peak heart rate, peak and mean power output, fatigue index, and total work. Significant treatment main effects were observed for mean power output (p = 0.026), total work (p = 0.020), fatigue index (p = 0.004), and heart rate (p = 0.013). Overall mean power output and total work were significantly greater with CHOI (659.3 ± 103.0 watts, 9849.8 ± 1598.8 joules) compared with CHOR (645.8 ± 99.7 watts, 9447.5 ± 1684.9 joules, p PLAI, and PLAR. Athletes required to complete repeat bouts of high intensity exercise may benefit from CHOI.

  5. Neutraliseeriv valge kuup / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2007-01-01

    XIV Tallinna graafikatriennaal "Poliitiline/Poeetiline" Kumu Kunstimuuseumis kuni 25. XI. Peapreemia pälvis Oscar Munose videoinstallatsioon "Memoriaali projekt", Eesti Panga preemia Haemin Choi. Poliitilisest kunstist. The Elfriede Jelinek School of the English Language'i teosest "Tooda või sure" (Sirp, 2007, 9. XI, lk. 24)

  6. Immunohistochemical classification and prognosis of diffuse large B-cell lymphoma in China

    Institute of Scientific and Technical Information of China (English)

    陈燕

    2014-01-01

    Objective To study the immunohistochemical classification and prognosis of diffuse large B-cell lymphoma(DLBCL).Methods A total of 148 cases of DLBCL were classified into germinal center B-cell-like(GCB)and non-GCB/activated B-cell-like(ABC)subtypes by Hans,Choi and Tally immunohistochemical stain algorithms.The clinical features and survival data of GCB

  7. Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans.

    Science.gov (United States)

    Chen, Jing; Zhang, Ju; Xiang, Yanxia; Xiang, Limin; Liu, Yongmei; He, Xiangjiu; Zhou, Xiaoju; Liu, Xin; Huang, Zebo

    2016-02-01

    Tsai Tai is one of the most widely consumed Brassica vegetables in Asian countries because of its good taste and its nutritional benefits. This study evaluated the antioxidant capacity and possible associated health benefits of 3 Tsai Tai (Brassica chinensis) varieties, namely, Hon Tsai Tai, Pak Choi and Choi Sum. The DPPH radical scavenging ability and reducing power assays were performed to evaluate the in vitro activities of the extracts. Caenorhabditis elegans was used as an in vivo model for evaluation of beneficial health effects, including antioxidant activity and delayed aging. In vitro, the Hon Tsai Tai extract exhibited higher antioxidant activities than Pak Choi and Choi Sum, and the total phenolic contents were significantly correlated with the DPPH and RP values. In vivo, the three assayed Tsai Tai extracts significantly increased resistance against paraquat-induced oxidative stress with an increase in survival rates from 15% to 28% compared with controls. However, only the extract from Hon Tsai Tai significantly prolonged the lifespan of Caenorhabditis elegans, with an 8% increase in the mean lifespan with respect to controls. Further evidence of antioxidant protection was obtained by assessing ROS production via the DCF assay. The analyses of intracellular SOD activity and MDA content confirmed the existence of an antioxidant protective effect. These results suggest that Tsai Tai might serve as a good source of natural antioxidants, and in particular, Hon Tsai Tai could be explored as a potential dietary supplement to retard aging.

  8. Rare earth elements in suspended and bottom sediments of the Mandovi estuary,central west coast of India: Influence of mining

    Digital Repository Service at National Institute of Oceanography (India)

    Shynu, R.; Rao, V.P.; Kessarkar, P.M.; Rao, T.G.

    -868. Vijith, V., Sundar, D., Shetye, S. R., 2009. Time-dependence of salinity in monsoonal estuaries. Estuarine, Coastal and Shelf Science 85, 601-608. Yang, S.Y., Jung, H.S., Choi, M.S., Li, C.X., 2002. The rare earth element compositions...

  9. Distribution and fractionation of rare earth elements and Yttrium in suspended and bottom sediments of the Kali estuary, western India

    Digital Repository Service at National Institute of Oceanography (India)

    Suja, S.; Fernandes, L.L.; Rao, V.P.

    around the Yellow Sea: implications for sediment provenance. Geo-Marine Lett 29: 291-300. Yang SY, Jung HS, Choi MS, Li CX (2002) The rare earth element compositions of the Changjiang (Yangtze) and Huanghe (Yellow) river sediments. Earth Planet Sci...

  10. Social policy and entitlements : a proposal for reform

    NARCIS (Netherlands)

    Nentjes, Andries; Meijer, G; Heijman, WJM; VanOphem, JAC; Verstegen, BHJ

    2006-01-01

    Welfare states citizens have entitlements to a variety of social services provided for free or a price far below cost, such as education, health care, social security and housing. Every citizen benefits, but in their present organisation the social services also have major deficiencies: lack of choi

  11. Exposure to Nickel, Chromium, or Cadmium Causes Distinct Changes in the Gene Expression Patterns of a Rat Liver Derived Cell Line

    Science.gov (United States)

    2011-11-16

    and pigments and is responsible for 500,000 industrial exposures in the United States [4,5]. Exposure to cadmium can occur as a result of mining...antioxidative/electrophilic response on the liver. Toxicol Appl Pharmacol 244: 57-65. 19. Ryter SW, Choi AM (2009) Heme oxygenase-1/carbon monoxide

  12. Microstructural Evolution in Laser Deposited Nickel-Titanium-Carbon in Situ Metal-Matrix Composites (Preprint)

    Science.gov (United States)

    2010-01-01

    investigated Ni-TiC composites processed by direct laser fabrication (DLF) from a feedstock of elemental nickel and titanium carbide powders. They focused... laser fabrication using powder and wire. Mater Design 2007; 28:2040-6. 3. Y. Choi, J. K. Lee, M. E. Mullins, J. Mater. Sci 32(1997) 1717-1724. 4

  13. Explaining television choices: the influence of parents and partners

    NARCIS (Netherlands)

    P. Hendriks Vettehen; R. Konig; H. Westerik; H. Beentjes

    2012-01-01

    The aim of the present study is to examine, on the one hand, whether adult television viewers’ choices are influenced by their childhood experience (i.e., their parents’ viewing choices) and, on the other hand, whether their choices are influenced by their current context (e.g., their partners’ choi

  14. The norm implementation problem in normative multi-agent systems

    NARCIS (Netherlands)

    Grossi, D.; Gabbay, D.; van der Torre, L.; Dastani, M.; Hindriks, K.V.; Meyer, J-J.C.

    2010-01-01

    The norm implementation problem consists in how to see to it that the agents in a system comply with the norms specified for that system by the system designer. It is part of the more general problem of how to synthesize or create norms for multi-agent systems, by, for example, highlighting the choi

  15. Validation of reference genes for real-time quantitative PCR normalisation in non-heading Chinese cabbage

    NARCIS (Netherlands)

    Xiao, D.; Zhang, N.; Jianjun Zhao, Jianjun; Bonnema, A.B.; Hou, X.L.

    2012-01-01

    Non-heading Chinese cabbage is an important vegetable crop that includes pak choi, caixin and several Japanese vegetables like mizuna, mibuna and komatsuna. Gene expression studies are frequently used to unravel the genetics of complex traits and in such studies the proper selection of reference gen

  16. Biological Impact of Senescence Induction in Prostate Cancer

    Science.gov (United States)

    2010-01-01

    that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367. 3. Collado M, Gil J, Efeyan A... Collado , M, Gil, J, Efeyan, A, et al. Tumour biology: senescence in premalignant tumours. Nature, 2005; 436(7051): 642. 15. Choi, J, Shendrik, I

  17. ConfidenceSets for Network Structure

    Science.gov (United States)

    2011-05-01

    David Choi, Patrick Wolfe Harvard University Office of Sponsored Research 1350 Massachusetts Ave. Holyoke 727 Cambridge, MA 02138 - REPORT...hence the identification of residual structure in the corresponding partition. K, and they are comprised of small numbers of students. This effect is due

  18. Un Genevois coopte a la tete du Front islamique du salut

    CERN Document Server

    Merckling, N

    2002-01-01

    "Le Front islamique du salut (FIS), a nomme a la tete de ce parti fondamentaliste un resident genevois, Mourad Dhani, chois parmi trois candidats. Ce physicien algerien est arrive a Geneve il y a 14 ans pour travailler au CERN (1 page).

  19. Prediction of Cavitating Waterjet Propulsor Performance Using a Boundary Element Method

    Science.gov (United States)

    2007-10-01

    Cavitation, September 11-15, 2006, Wageningen , The Netherlands. Kinnas, S.A., Choi, J.-K., Lee, H., Young, Y.L., Gu, H., Kakar, K. and Natarajan, S...inviscid component Propulsors and their Interaction interactive method", in CA V2006: Sixth International 13 Symposium on Cavitation, Wageningen , The

  20. QTL Information Table: 294 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality SSR C)Interval DHL IR64 Azucena B RM247 RM179 ph...a Stangoulis, J.C.R., Huynh, B.-L., Welch, R.M., Choi, E.-Y., and Graham, R.D. Quantitative trait loci for p

  1. Use of Payment Technology

    DEFF Research Database (Denmark)

    Xiao, Xiao; Hedman, Jonas; Runnemark, Emma

    2015-01-01

    Drawing on the theory of consumption value, this research-in-progress strives to provide a theoretical explanation of payment technology use by investigating the relationship between consumers’ perceptions of different consumption values associated with a certain payment technology and their choi...... behavior, as well as the debate on moving towards a cashless society....

  2. Prokaryotic cDNA Subtraction: A Method to Rapidly Identify Functional Gene Biomarkers

    Science.gov (United States)

    2008-10-01

    low temperature responsive (LOT) genes in Saccharomyces cerevisiae . Biochemical and Biophysical Research Communication 283:531-535. ...of different organic electron donors have been used successfully including acetate, ethanol , lactate, and pyruvate (Choi et al., 2007; Min et al...Saiki, D. Zhang, and F. Kawai. 2004. Cloning and characterization of preferentially expressed genes in an aluminum- tolerant mutant derived from

  3. Effects of Anthropometrics and Body Size Changes on the Development of Personal Protective Equipment (PPE) Sizing Systems in the US Army

    Science.gov (United States)

    2016-08-01

    Circumference distribution for ANSUR 1988 and ANSUR II 2012 with visualization of size categories of body armour, based on Chest Circumference The percent...Anthropometric change in the U.S. Army: Implication for design. Proceedings of the 9th Int. Congress of Physical Anthropology , pp 48-52. 7. Choi

  4. Is there a risk-return trade-off in educational choices? Evidence from Spain

    NARCIS (Netherlands)

    Díaz-Serrano, L.; Hartog, J.

    2006-01-01

    We use data from Spain to test for an effect of earnings variance and skewness on individual wages. We carry out separate estimations for men and women. In accordance with the scant previous evidence mainly focused on the US, we report the existence of a risk-return trade-off across educational choi

  5. Research on GaAs Quantum-Coupled Structures That Can be Used as Electron Devices

    Science.gov (United States)

    1989-01-26

    1985). [23] R. P. Feynman , Statistical Mechanics, A Set of Lectures (W. A. Benjamin, Reading, Mass., 1972), ch. 2. [24] A. Messiah, Quantum Mechanics...Fetter, Physica (Utrecht) 117& 118, 667 (1983). resistance with temperature) and decreases in current 8R. G. Wheeler , K. K. Choi, A. Goel, R. Wisnieff

  6. QTL Information Table: 293 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available cena B RM305 RM178 pha Stangoulis, J.C.R., Huynh, B.-L., Welch, R.M., Choi, E.-Y., and Graham, R.D. Quantitative trait loci for phyta...te in rice grain and their relationship with grain micronutrient content. Euphytica. http://dx.doi.org/10.1007/s10681-006-9211-7 ...

  7. Mogelijke aanvullingen op bestaande verkeerseducatiepakketten : inventarisatie ten behoeve van het project `educatie' van het Masterplan Fiets.

    NARCIS (Netherlands)

    Lindeijer, J.E. Twisk. D.A.M. & Wittink, R.D.

    1993-01-01

    This study mainly examines to what extent the aims of the existing educational teaching packages and publicity campaigns in the Netherlands support the new educational goals. These goals can be described as follows: (1) Educational programmes in the Netherlands should promote a more 'conscious' choi

  8. High-Performance Liquid Chromatography–Mass Spectrometry Analysis of Plant Metabolites in Brassicaceae

    NARCIS (Netherlands)

    Vos, de C.H.; Schipper, A.; Hall, R.D.

    2012-01-01

    The Brassicaceae family comprises a variety of plant species that are of high economic importance as -vegetables or industrial crops. This includes crops such as Brassica rapa (turnip, Bok Choi), B. oleracea (cabbages, broccoli, cauliflower, etc.), and B. napus (oil seed rape), and also includes the

  9. A Thousand Frames in Just a Few Words: Lingual Description of Videos through Latent Topics and Sparse Object Stitching (Open Access)

    Science.gov (United States)

    2013-10-03

    Besides there is 2 small bowls containing white color powders . It may be maida flour and sugar. After she is mixing the both powders in that big bowl...Y. Choi, A. C. Berg, and T. L. Berg. Baby talk: Understanding and generating simple image descriptions. In CVPR, 2011. [17] C.-Y. Lin and E. Hovy

  10. Use of Payment Technology

    DEFF Research Database (Denmark)

    Xiao, Xiao; Hedman, Jonas; Runnemark, Emma

    2015-01-01

    Drawing on the theory of consumption value, this research-in-progress strives to provide a theoretical explanation of payment technology use by investigating the relationship between consumers’ perceptions of different consumption values associated with a certain payment technology and their choi...

  11. Resilient Excellence: Challenges Faced by Trailblazing Women in U.S. Sport Psychology

    Science.gov (United States)

    Whaley, Diane E.; Krane, Vikki

    2012-01-01

    Consistent with other sciences (e.g., Kass-Simon, 1993; Tang, 2006), the field of kinesiology has been called a "masculine domain," which has an institutionalized culture biased against women (Brackenridge, Mutrie, & Choi, 2005). This paper represents the second part of a larger project that examined the life histories of eight trailblazing women…

  12. Reference: ABREATCONSENSUS [PLACE

    Lifescience Database Archive (English)

    Full Text Available ABREATCONSENSUS Choi HI, Park HJ, Park JH, Kim S, Im MY, Seo HH, Kim YW, Hwang I, Kim SY.... of Abscisic Acid-Responsive Gene Expression, and Modulates Its Activity. Plant Physiol. 139: 1750-1761(2005) PubMed: 16299177 ...

  13. A fine romance: T follicular helper cells and B cells.

    Science.gov (United States)

    King, Cecile

    2011-06-24

    T follicular helper (Tfh) cells help B cells to generate affinity-matured antibodies. Three papers in this issue of Immunity (Choi et al., 2011; Kerfoot et al., 2011; Kitano et al., 2011) provide information about the reciprocal relationship between B cells and Tfh cells. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Regulating cell-cell junctions from A to Z.

    Science.gov (United States)

    Hardin, Jeff

    2016-04-25

    Epithelial sheets often present a "cobblestone" appearance, but the mechanisms underlying the dynamics of this arrangement are unclear. In this issue, Choi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506115) show that afadin and ZO-1 regulate tension and maintain zonula adherens architecture in response to changes in contractility.

  15. Comparison of Automated and Manual Recording of Brief Episodes of Intracranial Hypertension and Cerebral Hypoperfusion and Their Association with Outcome After Severe Traumatic Brain Injury

    Science.gov (United States)

    2017-03-01

    Ward JD, Greenberg RP, Young HF, Sakalas R. The outcome from severe head injury with early diagnosis and intensive management. J Neurosurg. 1977; 47(4...Choi SC, et al. Further experience in the management of severe head injury. J Neurosurg. 1981; 54(3):289-299. 11. Narayan RK, Greenberg RP, Miller

  16. Iron content in forage sorghum (Sorghum bicolor (L.) Moench ...

    African Journals Online (AJOL)

    Administrator

    2011-09-12

    Sep 12, 2011 ... Byung Hoon Park1, Deok Jung Kim1, Kun Woo Park1, Mun Soo ... Jun Lee1, Yong Min Lee1, In Sub Choi1, Hyo Jeong Lee1, Jae Won .... already described in previous reports (Chang et al., 1993, Kim et ..... environment.

  17. Promoting Creativity in the Kitchen: Digital Lessons from the Learning Environment

    Science.gov (United States)

    Surgenor, Dawn; McMahon-Beattie, Una S. M.; Burns, Amy; Hollywood, Lynsey E.

    2016-01-01

    Creativity and learning are heightened when individuals are exposed to problem-solving activity (Y. Cho, Chung, Choi, Sea, & Baek, 2013); however, while creativity has historically been promoted in schools, educationalists experience difficulty in integrating it meaningfully to the curriculum (Y. Cho et al., 2013). This is relevant in terms of…

  18. Recent progress on technologies and applications of transgenic ...

    African Journals Online (AJOL)

    USER

    2010-06-14

    Jun 14, 2010 ... applications (Scott and Lois, 2005; van de Lavoir et al.,. 2006b ..... Kwon MS, Koo BC, Choi BR, Lee HT, Kim YH, Ryu WS, Shim H, Kim JH,. Kim NH, Kim .... Severino C, David FD, Shrikant D, Jennifer HD, Lynae G, Edward LH,.

  19. Social Awareness and Action Training (SAAT)

    Science.gov (United States)

    2015-06-01

    Riddle, Louise Hawkley, Maike Luhmann, Jessica Bell, Harry Reis, Alex Zautra, Katherine Nassauer, Ramon Prieto , D. Alan Nelson, Mike Fravell, Katie...The satisfaction with life scale. Journal of Personality Assessment, 49, 71-75. Diener, E., Wirtz, D., Tov, W., Kim- Prieto , C., Choi, D., Oishi, S

  20. "Speaking Back" from the English Periphery: Art-Work in a South Korean High School English Classroom

    Science.gov (United States)

    Craig, Martin; Porter, Curt

    2014-01-01

    South Korean English language teaching (ELT) has typically been represented as an arena dominated by excessive competition, test preparation, and the mastery of linguistic forms (Choi & Park, 2013; Park, 2009). These notions have been compounded by stereotypical depictions of Korean students as passive learners incapable of critical thinking…

  1. Disease: H00430 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 1 MeSH: D009221 OMIM: 135100 PMID:18328989 (gene, description) Kaplan FS, Le Merrer M, Glaser...eldman GJ, Fenstermacher DA, Cho TJ, Choi IH, Connor JM, Delai P, Glaser DL, LeMerrer M, Morhart R, Rogers J

  2. Disease: H00578 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available of cataracts and blue leukocyte inclusion bodies (Doehle-like bodies). Both disorders...iption) Kashtan CE, Segal Y Genetic disorders of glomerular basement membranes. Nephron Clin Pract 118:c9-c1...H, Park YS, Ha IS, Ahn HS, Choi Y, Cheong HI Renal manifestations of patients with MYH9-related disorders. Pediatr Nephrol 26:549-55 (2011) ...

  3. Electron and Hole Behavior in Powdered TiO2 - Photoluminescence and Infrared Studies

    Science.gov (United States)

    2014-04-01

    Surf. Sci. Rep. 2003, 48, 53-229. 3. Hoffmann, M. R.; Martin , S. T.; Choi, W. Y.; Bahnemann, D. W., Environmental Applications of Semiconductor...3936. 29. Solbrand, A.; Lindstrom , H.; Rensmo, H.; Hagfeldt, A.; Lindquist, S. E.; Sodergren, S., Electron Transport in the Nanostructured Tio2

  4. Applying Bioaugmentation to Treat DNAPL Sources in Fractured Rock

    Science.gov (United States)

    2017-03-27

    Micronutrients also may be needed, which can be supplied by amending with yeast extract ( Bach et al. 2005). Additional co-factors, such as vitamin...measurement of groundwater and contaminant fluxes. Environ. Sci. Technol. 39, 7194-7201. Bach , Q.-D., Kim, S.J., Choi, S.C., Oh, Y.-S. 2005

  5. Teisel pool fotot : üleval 70 tööd / Ragne Nukk

    Index Scriptorium Estoniae

    Nukk, Ragne, 1984-

    2011-01-01

    Rahvusvaheline fotonäitus "Teisele poole" Kumu Kunstimuuseumis 8. jaanuarini 2012, kuraator Adam Budak. Eksponeeritakse kollaaže, fotodest valmistatud skulptuure, videosid, fotosid, installatsioone. Lühidalt portugali kunstniku Helena Almeida, sakslase Stefan Burgeri, korea kunstniku Sunah Choi, ameeriklase Marlo Pascuali töödest. Näitus toimub Tallinna fotokuu raames

  6. Comment on "First-principles calculation of the superconducting transition in MgB2 within the anisotropic Eliashberg formalism"

    NARCIS (Netherlands)

    Mazin, I.I.; Andersen, O.K.; Jepsen, O.; Golubov, A.A.; Dolgov, O.V.; Kortus, J.

    2004-01-01

    Choi et al. [Phys. Rev. B 66, 020513 (2002)] recently presented first-principles calculations of the electron-phonon coupling and superconductivity in MgB2, emphasizing the importance of anisotropy and anharmonicity. We point out that (1) variation of the superconducting gap inside the sigma or the

  7. 7 July 2011 - Members of the Swiss Federal Council (front row) in front of the Globe of Science and Innovation.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    CERN-HI-1107166 01 1er rang: La chancelière Corina Casanova, le conseiller fédéral Johann N. Schneider-Ammann, le conseiller fédéral Ueli Maurer, la conseillère fédérale Eveline Widmer-Schlumpf, la conseillère fédérale Simonetta Sommaruga, la Présidente de la Confédération Micheline Calmy-Rey, le Directeur général du CERN Rolf Heuer, la conseillère fédérale Doris Leuthard, le conseiller fédéral Didier Burkhalter. 2è rang: Le vice-chancelier André Simonazzi , le vice-chancelier Thomas Helbling, la chef des relations internationales Felicitas Pauss, le directeur de la recherche et du calcul scientifique Sergio Bertolucci. 3è rang: Les scientifiques suisses: Ulrich Straumann (LHCb, Zürich et délégué suisse au Conseil du CERN), Rainer Wallny (CMS, ETHZ), Günther Dissertori (CMS, ETHZ), Antonio Ereditato (ATLAS, Bern), Tatsuya Nakada (LHCb, EPFL), Olivier Schneider (LHCb, EPFL), Martin Pohl (ATLAS, Genève), Vincenzo Chiochia (CM, Zürich), Giuseppe Iacobucci (ATLAS, Genève), le C...

  8. ATLAS rewards two pixel detector suppliers

    CERN Multimedia

    2007-01-01

    Peter Jenni, ATLAS spokesperson, presented the ATLAS supplier award to Herbert Reichl, IZM director, and to Simonetta Di Gioia, from the SELEX company.Two of ATLAS’ suppliers were awarded prizes at a ceremony on Wednesday 13 June attended by representatives of the experiment’s management and of CERN. The prizes went to the Fraunhofer Institut für Zuverlässigkeit und Mikrointegration (IZM) in Berlin and the company SELEX Sistemi Integrati in Rome for the manufacture of modules for the ATLAS pixel detector. SELEX supplied 1500 of the modules for the tracker, while IZM produced a further 1300. The modules, each made up of 46080 channels, form the active part of the ATLAS pixel detector. IZM and SELEX received the awards for the excellent quality of their work: the average number of faulty channels per module was less than 2.10-3. They also stayed within budget and on schedule. The difficulty they faced was designing modules based on electronic components and sensor...

  9. Data of methylome and transcriptome derived from human dilated cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Bong-Seok Jo

    2016-12-01

    Full Text Available Alterations in DNA methylation and gene expression have been implicated in the development of human dilated cardiomyopathy (DCM. Differentially methylated probes (DMPs and differentially expressed genes (DEGs were identified between the left ventricle (LV, a pathological locus for DCM and the right ventricle (RV, a proxy for normal hearts. The data in this DiB are for supporting our report entitled “Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy” (Bong-Seok Jo, In-Uk Koh, Jae-Bum Bae, Ho-Yeong Yu, Eun-Seok Jeon, Hae-Young Lee, Jae-Joong Kim, Murim Choi, Sun Shim Choi, 2016 [1].

  10. Holistic Reasoning on the Other Side of the World: Validation of the Analism/Holism Scale in Mexicans

    Science.gov (United States)

    Lechuga, Julia; Santos, Beatriz Maldonado; Garza-Caballero, Azenett A.; Villarreal, Ricardo

    2011-01-01

    The universality of cognitive processes has been called into question. Research suggests that individuals from Eastern cultures (e.g., China, Korea) when compared to individuals from Western cultures (e.g., the United States) prefer to reason holistically. This line of research has not been extended to cultural groups far removed from cultures traditionally surveyed in cross-cultural research such as Hispanics. We conducted two studies to understand: 1) the generalizability of the construct of holistic reasoning in Mexicans, and 2) the preferred reasoning style of Mexicans when compared to U.S. Americans. Results support the generalization of the factor structure of holistic reasoning as originally hypothesized by Choi, Koo, and Choi (2007). The results of Study 2 suggest that Mexicans scored higher than U.S. Americans on certain aspects of holistic reasoning. PMID:21787065

  11. Detection and Imaging of Slowly Moving Target of Airborne SAR Based on the GMCWD-Hough Transform

    Institute of Scientific and Technical Information of China (English)

    WANGLing; TAORar; ZHOUSiyong; WANGYue

    2004-01-01

    In this paper, the features of airborne SAR moving target echoes are analysed, the Generalizedmarginal Choi-Williams Distribution-Hough transform (GMCWD-HT) is also introduced. According to the echo model of airborne SAR, a new method based on the Generalized-marginal Choi-Williams Distribution-Hough transform for detecting and imaging the slowly moving targets of airborne SAR is proposed in the paper. This method can be used to perform the slowly moving target detection and imaging of airborne SAR in the low signal to clutter ratio, its detecting performance is better than the common method based on Wigner-Ville distribution. Computer simulation results have proven the validity of the approach.

  12. Holistic reasoning on the other side of the world: validation of the analysis-holism scale in Mexicans.

    Science.gov (United States)

    Lechuga, Julia; Santos, Beatriz Maldonado; Garza-Caballero, Azenett A; Villarreal, Ricardo

    2011-07-01

    The universality of cognitive processes has been called into question. Research suggests that individuals from Eastern cultures (e.g., China, Korea) when compared to individuals from Western cultures (e.g., the United States) prefer to reason holistically. This line of research has not been extended to cultural groups far removed from cultures traditionally surveyed in cross-cultural research such as Hispanics. We conducted two studies to understand: 1) the generalizability of the construct of holistic reasoning in Mexicans, and 2) the preferred reasoning style of Mexicans when compared to U.S. Americans. Results support the generalization of the factor structure of holistic reasoning as originally hypothesized by Choi, Koo, and Choi (2007). The results of Study 2 suggest that Mexicans scored higher than U.S. Americans on certain aspects of holistic reasoning.

  13. Reassurance Strategy: Incentives for Use and Conditions for Success

    Science.gov (United States)

    2010-03-01

    Costs and Benefits of Unification,” in Perspective on Korean Unification and Economic Integration, ed. Choi Young Back, Yesook Merrill , Yung Y. Yang...military leaders objecting to some of the measures discussed by Reagan and Gorbachev. After Reykjavik, Admiral William Crowe , chairman of the Joint...angry because there had been no consultation with them. Chairman of the Joint Chiefs of Staff Admiral William J. Crowe , Jr., spoke for the other

  14. Design Sensitivity Method for Sampling-Based RBDO with Fixed COV

    Science.gov (United States)

    2015-04-29

    contours of the input model at initial design d0 and RBDO optimum design dopt are shown. As the limit state functions are not linear and some input...Glasser, M. L., Moore, R. A., and Scott, T. C., 1990, "Evaluation of Classes of Definite Integrals Involving Elementary Functions via...Differentiation of Special Functions," Applicable Algebra in Engineering, Communication and Computing, 1(2), pp. 149-165. [25] Cho, H., Bae, S., Choi, K. K

  15. Some Additions to the Fuzzy Convergent and Fuzzy Bounded Sequence Spaces of Fuzzy Numbers

    OpenAIRE

    Şengönül, M.; Z. Zararsız

    2011-01-01

    Some properties of the fuzzy convergence and fuzzy boundedness of a sequence of fuzzy numbers were studied in Choi (1996). In this paper, we have consider, some important problems on these spaces and shown that these spaces are fuzzy complete module spaces. Also, the fuzzy α-, fuzzy β-, and fuzzy γ-duals of the fuzzy module spaces of fuzzy numbers have been computeded, and some matrix transformations are given.

  16. Efficient Algorithms for Bayesian Network Parameter Learning from Incomplete Data

    Science.gov (United States)

    2015-07-01

    Efficient Algorithms for Bayesian Network Parameter Learning from Incomplete Data Guy Van den Broeck∗ and Karthika Mohan∗ and Arthur Choi and Adnan...We propose a family of efficient algorithms for learning the parameters of a Bayesian network from incomplete data. Our approach is based on recent...algorithms like EM (which require inference). 1 INTRODUCTION When learning the parameters of a Bayesian network from data with missing values, the

  17. Spectral Conditions for Positive Maps

    Science.gov (United States)

    Chruściński, Dariusz; Kossakowski, Andrzej

    2009-09-01

    We provide partial classification of positive linear maps in matrix algebras which is based on a family of spectral conditions. This construction generalizes the celebrated Choi example of a map which is positive but not completely positive. It is shown how the spectral conditions enable one to construct linear maps on tensor products of matrix algebras which are positive but only on a convex subset of separable elements. Such maps provide basic tools to study quantum entanglement in multipartite systems.

  18. Constructing positive maps in matrix algebras

    Science.gov (United States)

    Chruściński, D.; Kossakowski, A.

    2011-10-01

    We analyze several classes of positive maps in infinite dimensional matrix algebras. Such maps provide basic tools for studying quantum entanglement infinite dimensional Hilbert spaces. Instead of presenting the most general approach to the problem we concentrate on specific examples. We stress that there is no general construction of positive maps. We show how to generalize well known maps in low dimensional algebras: Choi map in M3(C) and Robertson map in M4(C).

  19. Inference in Adaptive Regression via the Kac-Rice Formula

    Science.gov (United States)

    2014-05-15

    distribution, the Tracy- Widom law Johnstone (2001). In this case, our test statistic is based on the conditional distribution of λ1 given λ2...Tracy- Widom limit. The simulation is the work of Yunjin Choi, currently a Ph.D. student in- vestigating the use of the Kac-Rice pivot to inference in...PCA. The example is a rank-one example, demonstrating that the Kac-Rice test is competitive with the Tracy- Widom approximation of Johnstone (2001

  20. Disruption of Inhibitory Function in the Ts65Dn Mouse Hippocampus Through Overexpression of GIRK2

    Science.gov (United States)

    2007-10-24

    mouse cerebellum. Cerebellum 1:201- 206. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK...mouse: A model of Down syndrome. J Comp Neurol 494: 815-833, 2006. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K...cultured from both DS patients and model animals are also reportedly more vulnerable to apoptosis ( Sawa , 1999). A majority of research investigating cell

  1. Strategies for enhancing information, motivation, and skills for self-management behavior changes: a qualitative study of diabetes care for older adults in Korea

    OpenAIRE

    2014-01-01

    Suyoung Choi,1 Misoon Song,2 Sun Ju Chang,3 Se-an Kim4 1College of Nursing, Jeju National University, Jeju, Korea; 2College of Nursing, and The Research Institute of Nursing Science, Seoul National University, Seoul, Korea; 3Department of Nursing Science, Chungbuk National University, Cheongju, Korea; 4College of Nursing, Seoul National University, Seoul, Korea Purpose: To describe strategies for enhancing information, motivation, and skills related to changes in diabetes self-management beh...

  2. Measurement and Modeling of Ecosystem Risk and Recovery for In Situ Treatment of Contaminated Sediments. Phase 3

    Science.gov (United States)

    2015-08-01

    Choi was supported in part by a Samsung Scholarship. Collaboration with Newcastle University was facilitated by the Leverhulme Trust, grant FOO 125/AA...consuming and expensive . No fast, inexpensive field methods currently exist to predict the bio-uptake of contaminants and explain post-treatment...generate additional cost for the users. Therefore, we develop an executable program of the HOC mass transfer model using MATLAB Compiler™ (http

  3. Theoretical Study of Si(x)Ge(y)Li(z)- (x=4-10, y=1-10, z=0-10) Clusters for Designing of Novel Nanostructured Materials to be Utilized as Anodes for Lithium-Ion Batteries

    Science.gov (United States)

    2015-03-16

    Zhang, X. F.; Huggins, R. A.; Cui, Y. Nature Nanotechnology 2008, 3, 31. (4) Key, B.; Bhattacharyya, R.; Morcrette, M.; Seznec, V.; Tarascon, J. M...Grey, C. P. Journal of the American Chemical Society 2009, 131, 9239. (5) Perez-Peralta, N.; Boldyrev, A. I. Journal of Physical Chemistry A 2011...115, 11551. (6) Perez-Peralta, N.; Boldyrev, A. I. Unpublished manuscript. (7) Song, T.; Cheng, H.; Choi, H.; Lee, J.-H.; Han , H.; Lee, D. H.; Yoo, D

  4. Decomposition of Superimposed Waveforms Using the Cross Time Frequency Transform

    Science.gov (United States)

    2007-11-02

    Decomposition of Myoelectric Signals .” IEEE Engineering in Medicine and Biology. (June): pp 24-28. [5] Choi, H.I., Williams, W.J. Improved time...and De Luca, C. J. (1982). “A Procedure for Decomposing the Myoelectric Signal into its Constituent Action Potentials. Part I. Technique, Theory...throughout a muscle contraction. This paper addresses a specific aspect of the identification process: the decomposition of the compound signal

  5. Fundamentals of Aerodynamic-Flow and Combustion Control by Plasmas

    Science.gov (United States)

    2010-05-14

    decreased gas pressure [1]. Here we propose a system which can lead to ignition under conditions of automotive engines , including HCCI , gas...Discharge Plasma Richard Whalley & Kwing-So Choi Faculty of Engineering , University of Nottingham University Park, Nottingham NG7 2RD, UK... engines , and various designs of electric propulsion systems for satellites. As computer capabilities improve rapidly, the ability to model non

  6. Can Profit Policy and Contract Incentives Improve Defense Contract Outcomes?

    Science.gov (United States)

    2009-02-01

    team for their contributions and suggestions, including Bruce R. Harmon, Christopher S. Wait, Karen W. Tyson, Sunjin Choi, and Byron Callan. The...peer industries, and broader industry segments for the period 1989–2006. Aside from 1993 and the sharp technology downturn after 2000, the defense...effects of profit policy on contractor profits can only be inferred. Profits and capital are influenced by numerous market factors, government profit

  7. Quasiperiodic Strain Bursts and Self-Organization in Crystal Microplasticity (PREPRINT)

    Science.gov (United States)

    2012-03-01

    AFRL-RX-WP-TP-2012-0249 QUASIPERIODIC STRAIN BURSTS AND SELF- ORGANIZATION IN CRYSTAL MICROPLASTICITY (PREPRINT) D.M. Dimiduk Metals...2012 4. TITLE AND SUBTITLE QUASIPERIODIC STRAIN BURSTS AND SELF-ORGANIZATION IN CRYSTAL MICROPLASTICITY (PREPRINT) 5a. CONTRACT NUMBER In-house...18 Quasiperiodic strain bursts and self-organization in crystal microplasticity S. Papanikolaou,1,2∗ D. M. Dimiduk,3 W. Choi4, J. P. Sethna4, M. D

  8. Supply Chain Security. Tools, Trends, and Techniques : Toyota and Honda cases

    OpenAIRE

    Klimova, Nadezda; Akimova, Anna

    2011-01-01

      Supply chain management has experienced great changes within the last fifty years. Inevitably, many companies entered the global market with the prime intention to achieve their defined goals. In comparison with the local markets, the global environment requires more efforts and changes in the supply chain operation in order to remain viable in business. Several business models are introduced for achieving the success in the market, suggested by the following researchers: Liker, Choi, Ronal...

  9. High Efficiency Flexible Battery Based on Graphene-carbon Nanotube Hybrid Structure

    Science.gov (United States)

    2015-02-26

    transparent and flexible polyethylene terephthalate (PET) film through a simple lamination process- structural integrity, low contact resistance...and flexible polyethylene terephthalate (PET) film through a simple lamination process- structural integrity, low contact resistance, excellent C...Choi, Carbon 77 1065(2014) 2. Hierarchical NiCo2O4 @nickel-sulfide nanoplate arrays for high-performance supercapacitors, Chu Q, Wang W, Wang X

  10. GABAA Receptor-Mediated Activity in a Model of Cortical Dysplasia

    Science.gov (United States)

    2012-06-29

    epilepsy, autism and schizophrenia, and results from failure of immature neurons to appropriately migrate to their cortical targets. We developed a...schizophrenia, and autism , and results from failure of immature neurons to appropriately migrate and reach their cortical targets (Taylor et al., 1971; Choi and...appropriate cortical target is regulated by Brn1 and Brn2, POU-domain transcription factors that regulate the reelin /DAB1 pathway, and cyclin

  11. Modified Bayesian Kriging for Noisy Response Problems for Reliability Analysis

    Science.gov (United States)

    2015-01-01

    surrogate model is used to do the MCS prediction for the reliability analysis for the sampling- based reliability-based design optimization ( RBDO ) method...D., Choi, K. K., Noh, Y., & Zhao, L. (2011). Sampling-based stochastic sensitivity analysis using score functions for RBDO problems with correlated...K., and Zhao, L., (2011). Sampling- based RBDO using the stochastic sensitivity analysis and dynamic Kriging method. Structural and

  12. Sampling-Based RBDO Using Stochastic Sensitivity and Dynamic Kriging for Broader Army Applications

    Science.gov (United States)

    2011-08-09

    AND DYNAMIC KRIGING FOR BROADER ARMY APPLICATIONS K.K. Choi, Ikjin Lee, Liang Zhao, and Yoojeong Noh Department of Mechanical and Industrial...Thus, for broader Army applications, a sampling-based RBDO method using surrogate model has been developed recently. The Dynamic Kriging (DKG) method...Uuing Stochastic Sensitivity and Dynamic Kriging for Broader Army Applications 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6

  13. Design of water shock tube for testing shell materials

    OpenAIRE

    Ji, Hongjuan; Mustafa, Mohamad; Khawaja, Hassan Abbas; Ewan, Bruce C.; Moatamedi, Mojtaba

    2014-01-01

    This paper presents design considerations for a shock tube experimental rig used to investigate the dynamic failure mechanisms of shell geometries subjected to water shock impact loading. In such setup, it is desirable that the drive pressure used within the tube can provide a wide range of impulsive loads on the test structures and some flexibility can be achieved on the applied pulse durations. With this aim a review of various existing shock tube experimental setup is presented and choi...

  14. Supply Chain Security. Tools, Trends, and Techniques : Toyota and Honda cases

    OpenAIRE

    Klimova, Nadezda; Akimova, Anna

    2011-01-01

      Supply chain management has experienced great changes within the last fifty years. Inevitably, many companies entered the global market with the prime intention to achieve their defined goals. In comparison with the local markets, the global environment requires more efforts and changes in the supply chain operation in order to remain viable in business. Several business models are introduced for achieving the success in the market, suggested by the following researchers: Liker, Choi, Ronal...

  15. Advanced Optical Technologies for Defense Trauma and Critical Care

    Science.gov (United States)

    2014-02-04

    and human tracheas, with visualization around the entire circumference of the airway, and high resolution visualization of subsurface tissue layers...lumen of excised pig and human tracheas, with visualization around the entire circumference of the airway, and high resolution visualization of...Optical Coherence Tomography in the Rabbit,” JAMA Otolaryngol. Head Neck Surg. 139, 503-8 (2013). 16. Liu, G., W. Jia, V. Sun, B. Choi and Z. Chen

  16. Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

    OpenAIRE

    Ganesan P; Arulselvan P; Choi DK

    2017-01-01

    Palanivel Ganesan,1,2 Palanisamy Arulselvan,3 Dong-Kug Choi1,2 1Nanotechnology Research Center and Department of Applied Life Science, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 3Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia Abstract: Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by ...

  17. Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

    OpenAIRE

    Ganesan, Palanivel; Arulselvan, Palanisamy; Choi, Dong-Kug

    2017-01-01

    Palanivel Ganesan,1,2 Palanisamy Arulselvan,3 Dong-Kug Choi1,2 1Nanotechnology Research Center and Department of Applied Life Science, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 3Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia Abstract: Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by ...

  18. Effects of Different Organic Materials and Exogenous Zn on Zn Distribution in Soil

    OpenAIRE

    HAO Jia-li; BU Yu-shan; JIA Zheng-rong; XI Ji-long; YAO Jing-zhen; Duan, Chao

    2015-01-01

    A pot experiment with a complete combinatorial design of two factors was conducted to study the effects of different organic materials and different concentrations of exogenous zinc on the soil total zinc, available zinc, zinc forms and zinc content distribution of pak-choi. The results showed that the total zinc, available zinc, and different forms of zinc contents in soil all increased as the concentration of exogenous zinc increased. Both lawn grass and maize straw decreased the total zinc...

  19. Layer by Layer Growth of 2D Quantum Superlattices (NBIT III)

    Science.gov (United States)

    2017-02-28

    AFRL-AFOSR-JP-TR-2017-0019 Layer-by-Layer Growth of 2D Quantum Superlattices (NBIT III) Jiwoong Park CORNELL UNIVERSITY Final Report 02/22/2017...NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) CORNELL UNIVERSITY 373 PINE TREE RD ITHACA, NY 14850-2820 US 8. PERFORMING ORGANIZATION...age) Hee Cheul Choi (44) Full Name (age) Jiwoong Park (41) Nationality Korea Nationality Korea (US Resident ) Affiliation (department) POSTECH

  20. Spherical Indentation Testing of Poroelastic Relaxations in Thin Hydrogel Layers

    Science.gov (United States)

    2012-01-01

    R. Paul , J. Polym. Sci., Part B: Polym. Phys., 2010, 48, 1685– 1718. 3 B. C. H. Steele and A. Heinzel, Nature, 2001, 414, 345–352. 4 M. A. Hickner, H...4351. 6 B.-S. Kim and J.-W. Choi, Biotechnol. Bioprocess Eng., 2007, 12, 323– 332. 7 S. Kim, J.-H. Kim, O. Jeon , I. C. Kwon and K. Park, Eur. J. Pharm

  1. Non-Markovianity of Gaussian Channels.

    Science.gov (United States)

    Torre, G; Roga, W; Illuminati, F

    2015-08-14

    We introduce a necessary and sufficient criterion for the non-Markovianity of Gaussian quantum dynamical maps based on the violation of divisibility. The criterion is derived by defining a general vectorial representation of the covariance matrix which is then exploited to determine the condition for the complete positivity of partial maps associated with arbitrary time intervals. Such construction does not rely on the Choi-Jamiolkowski representation and does not require optimization over states.

  2. Effects of tai chi qigong on psychosocial well-being among hidden elderly, using elderly neighborhood volunteer approach: a pilot randomized controlled trial

    OpenAIRE

    Chan AW; Yu DS; Choi KC

    2017-01-01

    Aileen WK Chan, Doris SF Yu, KC Choi The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Purpose: To test the feasibility and preliminary effectiveness of a tai chi qigong program with the assistance of elderly neighborhood volunteers in strengthening social networks and enhancing the psychosocial well-being of hidden elderly. Patients and methods: “Hidden elderly” is a term used to describe older adults w...

  3. Tessinarna i Venedig

    OpenAIRE

    2009-01-01

    The Tessins in VeniceForeign royalty and other travelers visiting Venice in the early eighteenth century encountered a flourishing of the arts. This vibrant artistic life could be transposed to new settings, as a number of Venetian painters worked for courts north of the Alps. When the statesman and connoisseur Carl Gustaf Tessin, Swedish Ambassador to Vienna, visited Venice in 1736, it was with the intention of hiring a decorative painter for the new royal palace in Stockholm. His first choi...

  4. Simultaneous Extraction of Lithium and Hydrogen from Seawater

    Science.gov (United States)

    2011-08-22

    N00014-10-M-0234 20126083 0001AD Dr. Pyoungho Choi University of Central Florida/Florida Solar Energy Center 1679 Clearlake Road Cocoa FL 32922-5703...seawater can be carried out either desalination of sea water and followed by the well-established fresh water electrolysis or direct electrolysis of sea...water, the latter seems more attractive because the desalination often employs the reverse osmosis process that not only requires additional cost

  5. An Implantable MEMS Drug Delivery Device for Rapid Delivery in Ambulatory Emergency Care

    Science.gov (United States)

    2009-06-01

    even engaged 2 telemetrically, as opposed to passive devices that depend on the degradation chemistry of the specific device materials in the...cardioverter-defibrillator," American Journal of Cardiology , vol. 85, pp. 981-985, 2000. A. C. R. Grayson, I. S. Choi, B. M. Tyler, P. P. Wang...cardioverter defibrillator patients," Journal of Interventional Cardiology , vol. 11, pp. 205-211, 1998. M. Staples, K. Daniel, M. J. Cima, and R

  6. Reference: 754 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available . Roles of phosphatidylinositol 3-kinase in root hair growth. 2 624-35 18408046 2008 Jun Plant physiology Bak Gwangbae|Cho Hyung-Taeg|Choi Yunjung|Chuang Wen-I|Lee Youngsook|Lee Yuree ... 754 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18408046i Lee Yuree

  7. Stabilization of Monodomain Polarization in Ultrathin PbTiO3 Films

    Science.gov (United States)

    2016-06-13

    Stephenson,1 Carol Thompson,3 D. M. Kim,4 K. J. Choi,4 C. B. Eom,4 I. Grinberg,2 and A. M. Rappe2 1Materials Science Division, Argonne National...Pennsylvania 19104, USA 3Department of Physics, Northern Illinois University, DeKalb, Illinois 60115, USA 4Department of Materials Science and Engineering...surface. The polarization direction is predicted to depend on the chemi- cal nature of the adsorbate. The conducting substrates were epitaxial SrRuO3

  8. Functionalized Graphene Reinforced Thermoplastic Nanocomposites as Strain Sensors in Structural Health Monitoring (Preprint)

    Science.gov (United States)

    2012-02-01

    boat and kept in a furnace and hydrogen exfoliated at 200°C for 30 s with a flow of hydrogen gas and resulting graphene in powder form was collected.16...16. A. Kaniyoor, T. T. Baby and S. Ramaprabhu, J. Mater. Chem., 2010, 20, 8467-8469. 17. S.-M. Choi, S.-H. Jhi and Y.-W. Son, Nano Lett., 2010, 10, 3486- 3489. 4Approved for public release; distribution unlimited.

  9. Optimal Licensing for Public Intellectual Property: Theory and Application to Plant Variety Patents

    OpenAIRE

    Julian M. Alston; Plakias, Zoe T.

    2014-01-01

    In the United States, public universities may choose to license a plant variety to a limited number of producers (an exclusive license) or to an unlimited number of producers (an open license). This choice has implications for the quantity and distribution of total benefits from the variety. Universities have traditionally released new apple varieties under open licenses, but several universities have now begun exploring or implementing exclusive licensing. In this paper, we consider the choi...

  10. Strategies to improve compliance among oral contraceptive pill users: a review of the literature

    OpenAIRE

    Choi A; Dempsey A

    2014-01-01

    Angela Choi, Angela DempseyDepartment of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USAAbstract: Oral contraceptive pills (OCPs) remain the most commonly used reversible birth control method. Failure to adhere to daily pill taking and gaps in use are common and contribute to the risk of unintended pregnancy among OCP users. OCP compliance is influenced by a complex interplay of cognitive, behavioral, logistic, clinical, and social factors. This review out...

  11. Nanoscience

    Science.gov (United States)

    2011-07-22

    Performance Macromolecular Materials, 28 February 2010, ADA518688, http://handle.dtic.mil/100.2/ADA518688. Hahn, H.T.; Choi, O.; and Wang , Zhe ...Silica Microspheres [2]  Solid phase microextraction (SPME) [3] Footnotes 1. http://en.wikipedia.org/wiki/Dip-coating 2. Wang , Y. et al...Approved for public release; distribution is unlimited 21 Wang , Y.; Chen, L.; Yang, H.; Guo, Q.; Zhou, W.; and Tao, M., University of Texas

  12. Thin Film Assembly of Spider Silk-like Block Copolymers

    Science.gov (United States)

    2011-01-01

    Film Assembly of Spider Silk -like Block Copolymers Sreevidhya T. Krishnaji,†,‡ Wenwen Huang,§ Olena Rabotyagova,†,‡ Eugenia Kharlampieva, ) Ikjun Choi...Received November 26, 2010 We report the self-assembly of monolayers of spider silk -like block copolymers. Langmuir isotherms were obtained for a series of...bioengineered variants of the spider silks , and stable monolayers were generated. Langmuir-Blodgett films were prepared by transferring the monolayers

  13. Solid State Research

    Science.gov (United States)

    2007-11-02

    Semiconductor Lasers H. K. Choi Optical Society of America Annual Meeting, Baltimore, Maryland, 4-9 October 1998 Extending the Cutoff Wavelength of...bioluminescent protein originally found in a glowing species of jellyfish , and the cells are attached to the surface of a charge-coupled device (CCD...grown for periods of several years in an artificial environment with the appropriate temperature, gases, and culture medium. We obtained the jellyfish

  14. In-situ Manipulation and Imaging of Switchable Two-dimensional Electron Gas at Oxide Heterointerfaces

    Science.gov (United States)

    2016-11-30

    M. K. Mahanthappa, M. S. Rzchowski, and C. B. Eom, Applied Physics Letters , 109, 191604 (2016) 2. “Electro-mechanical response of top-gated LaAlO3...at a metal/oxide interface”. Kyungjoon Baek, Sangsu Park, Jucheol Park, Young -Min Kim, Sang Ho Oh, accepted for publication in Nanoscale (2016). DOI...electron liquid at oxide interfaces”, Kyung Song, Sangwoo Ryu, Hyungwoo Lee, Si- Young Choi, Tula R. Paudel, Christoph T. Koch, Mark S. Rzchowski

  15. Herd behaviour, strategic complementarities and technology adoption

    OpenAIRE

    2004-01-01

    In technology adoption, herd behaviour can lead to a suboptimal outcome. An example is given by Choi (1997): it is a model of technology choice under uncertainty where herding arises because of strategic complementarities and risk aversion. It causes a positive experimenting bias against the adoption of a more efficient (in terms of expected value) technology. We introduce in his model an additional element upon which firms base their technology decision: the economic environment. We investig...

  16. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

    OpenAIRE

    Ganesan P.; Choi DK

    2016-01-01

    Palanivel Ganesan,1,2 Dong-Kug Choi1,2 1Department of Applied Life Science, Nanotechnology Research Center, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea Abstract: Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower pene...

  17. Batteries: encapsulated monoclinic sulfur for stable cycling of li-s rechargeable batteries (adv. Mater. 45/2013).

    Science.gov (United States)

    Moon, San; Jung, Young Hwa; Jung, Wook Ki; Jung, Dae Soo; Choi, Jang Wook; Kim, Do Kyung

    2013-12-03

    On page 6547 Do Kyung Kim, Jang Wook Choi and co-workers describe a highly aligned and carbon-encapsulated sulfur cathode synthesized with an AAO template that exhibits a high and long cycle life, and the best rate capability based on the complete encapsulation of sulfur (physical) and implementation of the monoclinic sulfur phase (chemical). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  18. A cost-analysis of complex workplace nutrition education and environmental dietary modification interventions

    OpenAIRE

    Fitzgerald, Sarah; Kirby, Ann; Murphy, Aileen; Geaney, Fiona; Perry, Ivan J.

    2017-01-01

    Background The workplace has been identified as a priority setting to positively influence individuals’ dietary behaviours. However, a dearth of evidence exists regarding the costs of implementing and delivering workplace dietary interventions. This study aimed to conduct a cost-analysis of workplace nutrition education and environmental dietary modification interventions from an employer’s perspective. Methods Cost data were obtained from a workplace dietary intervention trial, the Food Choi...

  19. Balancing the Rates of New Bone Formation and Polymer Degradation Enhances Healing of Weight-Bearing Allograft/Polyurethane Composites in Rabbit Femoral Defects

    Science.gov (United States)

    2014-10-03

    and Pelo, S. Cranial reshaping using methyl methacrylate: technical note. J Craniofac Surg 20, 184, 2009. 13. Moreira Gonzalez, A., Jackson, I.T...trabecular bone from the femur, and some factors affecting the shear strength of the cement bone interface. Arch Orthop Trauma Surg 92, 19, 1978. Epub 1978...bearing protocol. Orthopaedic Trauma Association, Balti more, MD, 2010. 54. Kim, S.S., Sun Park, M., Jeon, O., Yong Choi, C., and Kim, B.S. Poly(lactide

  20. Polaractivation for classical zero-error capacity of qudit channels

    Energy Technology Data Exchange (ETDEWEB)

    Gyongyosi, Laszlo, E-mail: gyongyosi@hit.bme.hu [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117, Hungary and Information Systems Research Group, Mathematics and Natural Sciences, Hungarian Ac (Hungary); Imre, Sandor [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117 (Hungary)

    2014-12-04

    We introduce a new phenomenon for zero-error transmission of classical information over quantum channels that initially were not able for zero-error classical communication. The effect is called polaractivation, and the result is similar to the superactivation effect. We use the Choi-Jamiolkowski isomorphism and the Schmidt-theorem to prove the polaractivation of classical zero-error capacity and define the polaractivator channel coding scheme.

  1. Flavor vs Energy Sensing in Brain Reward Circuits

    OpenAIRE

    de Araujo, Ivan E.

    2014-01-01

    Sweetness functions as a potent natural reinforcer in several species, from flies to rodents to primates including humans. The appreciation of flavored stimuli is greatly enhanced when sweetness is added, the obvious example being sugar-sweetened flavored beverages (the major source of excess added calories in US diets). Different sweet substances are nevertheless attributed greater incentive value than others, with glucose-containing sugars appearing as the uppermost sweet reward. Food choi...

  2. An Exploration of the Lived Experiences of Year Six Children on a Residential Trip to Normandy

    Science.gov (United States)

    Green, Michael

    2017-01-01

    Over the last decade, a plethora of research has been undertaken into learning outside the classroom and its resultant benefits on pupils [Dillon, J., M. Rickinson, K. Teamey, M. Morris, M. Y. Choi, D. Sanders, and P. Benefield. 2006. "The Value of Outdoor Learning: Evidence from Research in the UK and Elsewhere." "School Science…

  3. The Pre-Blast Concept for use on Armour Materials

    Science.gov (United States)

    2016-02-01

    deviation is giving in this study. 2.3 Electron Back Scattered Diffraction (EBSD) The microstructure was also analyzed by the electron back ... give rise to performance variations under conditions of rapid loading [8]. To assess the materials for toughness, crack starter weld beads were...UNCLASSIFIED UNCLASSIFIED The Pre-Blast Concept for use on Armour Materials C. Choi1, C. Peng2 and B. Dixon1 1Land Division Defence

  4. Towards Thermal Wavelength Scale Two- and Three-Dimensional Photonic Crystals

    Science.gov (United States)

    2016-04-01

    10.1038/ncomms6075 5. J. Liu, G.-M. Choi, and D.G. Cahill, " Measurement of the anisotropic thermal conductivity of molybdenum disulfide by the time...thin-film silicon on its thermoelectric figure of merit, the anisotropic thermal conductivity of nanoscale graphite layers and the changes in the...this now. We studied the anisotropic thermal conductivity of nanoscale graphite layers deposited by chemical vapor deposition on Ni substrates at

  5. Modeling and Performance Evaluation of Backoff Misbehaving Nodes in CSMA/CA Networks

    Science.gov (United States)

    2012-08-01

    range of backoff misbehaviors on network performance in CSMA/CA-based wireless networks. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17...consider the same transmission process under a different MAC protocol, such as ZigBee or even different 802.11 models, the packet delay will change because...Layer Misbeha- vior in Wireless Networks,” ACM Trans. Information and Systems Security , vol. 11, no. 4, pp. 19:1-19:28, July 2008. [10] S. Choi, K

  6. Effect of mouth rinsing and ingestion of carbohydrate solutions on mood and perceptual responses during exercise.

    Science.gov (United States)

    Ali, Ajmol; Moss, Catherine; Yoo, Michelle Ji Yeon; Wilkinson, Alanah; Breier, Bernhard H

    2017-01-01

    The aim of this study was to investigate whether mouth rinsing or ingesting carbohydrate (CHO) solutions impact on perceptual responses during exercise. Nine moderately trained male cyclists underwent a 90-min glycogen-reducing exercise, and consumed a low CHO meal, prior to completing an overnight fast. A 1-h cycle time trial was performed the following morning. Four trials, each separated by 7 days, were conducted in a randomized, counterbalanced study design: 15% CHO mouth rinse (CHOR), 7.5% CHO ingestion (CHOI), placebo mouth rinse (PLAR) and placebo ingestion (PLAI). Solution volumes (1.5 ml · kg(-1) ingestion trials and 0.33 ml · kg(-1) rinsing trials) were provided after every 12.5% of completed exercise. Perceptual scales were used to assess affective valence (feeling scale, FS), arousal (felt arousal scale, FAS), exertion (ratings of perceived exertion, RPE) and mood (profile of mood states, POMS) before, during and immediately after exercise. There was no difference in RPE (CHOI, 14.0 ± 1.9; CHOR, 14.2 ± 1.7; PLAI, 14.6 ± 1.8; PLAR, 14.6 ± 2.0; P = 0.35), FS (CHOI, 0.0 ± 1.7; CHOR, -0.2 ± 1.5; PLAI, -0.8 ± 1.4; PLAR, -0.8 ± 1.6; P = 0.15), or FAS (CHOI, 3.6 ± 1.1; CHOR, 3.5 ± 1.0; PLAI, 3.4 ± 1.4; PLAR, 3.3 ± 1.3; P = 0.725) scores between trials. While overall POMS score did not appear to differ between trials, the 'vigour' subscale indicated that CHOI may facilitate the maintenance of 'vigour' scores over time, in comparison to the steady decline witnessed in other trials (P = 0.04). There was no difference in time trial performance between trials (CHOI, 65.3 ± 4.8 min; CHOR, 68.4 ± 3.9 min; PLAI, 68.7 ± 5.3 min; PLAR, 68.3 ± 5.2 min; P = 0.21) but power output was higher in CHOI (231.0 ± 33.2 W) relative to other trials (221-223.6 W; P < 0.01). In a CHO-reduced state, mouth rinsing with a CHO solution did not impact on

  7. Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteria

    Directory of Open Access Journals (Sweden)

    Ochman Howard

    2009-09-01

    Full Text Available Abstract Background Because bacteria do not have a robust fossil record, attempts to infer the timing of events in their evolutionary history requires comparisons of molecular sequences. This use of molecular clocks is based on the assumptions that substitution rates for homologous genes or sites are fairly constant through time and across taxa. Violation of these conditions can lead to erroneous inferences and result in estimates that are off by orders of magnitude. In this study, we examine the consistency of substitution rates among a set of conserved genes in diverse bacterial lineages, and address the questions regarding the validity of molecular dating. Results By examining the evolution of 16S rRNA gene in obligate endosymbionts, which can be calibrated by the fossil record of their hosts, we found that the rates are consistent within a clade but varied widely across different bacterial lineages. Genome-wide estimates of nonsynonymous and synonymous substitutions suggest that these two measures are highly variable in their rates across bacterial taxa. Genetic drift plays a fundamental role in determining the accumulation of substitutions in 16S rRNA genes and at nonsynonymous sites. Moreover, divergence estimates based on a set of universally conserved protein-coding genes also exhibit low correspondence to those based on 16S rRNA genes. Conclusion Our results document a wide range of substitution rates across genes and bacterial taxa. This high level of variation cautions against the assumption of a universal molecular clock for inferring divergence times in bacteria. However, by applying relative-rate tests to homologous genes, it is possible to derive reliable local clocks that can be used to calibrate bacterial evolution. Reviewers This article was reviewed by Adam Eyre-Walker, Simonetta Gribaldo and Tal Pupko (nominated by Dan Graur.

  8. Investigation of Sooting in Microgravity Droplet Combustion: Fuel-Dependent Effects

    Science.gov (United States)

    Manzello, Samuel L.; Hua, Ming; Choi, Mun Young

    1999-01-01

    Kumagai and coworkers first performed microgravity droplet combustion experiments [Kumagai, 1957]. The primary goal of these early experiments were to validate simple 'd(sup 2)-law models [Spalding, 1954, Godsave, 1954] Inherent in the 'd(sup 2) -law' formulation and in the scope of the experimental observation is the neglect of sooting behavior. In fact, the influence of sooting has not received much attention until more recent works [Choi et al., 1990; Jackson et al., 1991; Jackson and Avedisian, 1994; Choi and Lee, 1996; Jackson and Avedisian, 1996; Lee et al., 1998]:. Choi and Lee measured soot volume fraction for microgravity droplet flames using full-field light extinction and subsequent tomographic inversion [Choi and Lee, 1996]. In this investigation, soot concentrations were measured for heptane droplets and it was reported that soot concentrations were considerably higher in microgravity compared to the normal gravity flame. It was reasoned that the absence of buoyancy and the effects of thermophoresis resulted in the higher soot concentrations. Lee et al. [1998] performed soot measurement experiments by varying the initial droplet diameter and found marked influence of sooting on the droplet burning behavior. There is growing sentiment that sooting in droplet combustion must no longer be neglected and that "perhaps one of the most important outstanding contributions of (micro)g droplet combustion is the observation that in the absence of asymmetrical forced and natural convection, a soot shell is formed between the droplet surface and the flame, exerting an influence on the droplet combustion response far greater than previously recognized." [Law and Faeth, 1994]. One of the methods that we are exploring to control the degree of sooting in microgravity is to use different fuels. The effect of fuel structure on sooting propensity has been investigated for over-ventilated concentric coflowing buoyant diffusion flames. (Glassman, 1996]. In these

  9. Viable tumor volume: Volume of interest within segmented metastatic lesions, a pilot study of proposed computed tomography response criteria for urothelial cancer

    Energy Technology Data Exchange (ETDEWEB)

    Folio, Les Roger, E-mail: Les.folio@nih.gov [Lead Radiologist for CT, NIH Radiology and Imaging Sciences, 10 Center Drive, Bethesda, MD 20892 (United States); Turkbey, Evrim B., E-mail: evrimbengi@yahoo.com [Johns Hopkins University, Baltimore, MD 21218 (United States); Steinberg, Seth M., E-mail: steinbes@mail.nih.gov [Head, Biostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, 9609 Medical Center Drive, Room 2W334, MSC 9716, Bethesda, MD 20892 (United States); Apolo, Andrea B. [Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 (United States)

    2015-09-15

    Highlights: • It is clear that 2D axial measurements are incomplete assessments in metastatic disease; especially in light of evolving antiangiogenic therapies that can result in tumor necrosis. • Our pilot study demonstrates that taking volumetric density into account can better predict overall survival when compared to RECIST, volumetric size, MASS and Choi. • Although volumetric segmentation and further density analysis may not yet be feasible within routine workflows, the authors believe that technology advances may soon make this possible. - Abstract: Objectives: To evaluate the ability of new computed tomography (CT) response criteria for solid tumors such as urothelial cancer (VTV; viable tumor volume) to predict overall survival (OS) in patients with metastatic bladder cancer treated with cabozantinib. Materials and methods: We compared the relative capabilities of VTV, RECIST, MASS (morphology, attenuation, size, and structure), and Choi criteria, as well as volume measurements, to predict OS using serial follow-up contrast-enhanced CT exams in patients with metastatic urothelial carcinoma. Kaplan–Meier curves and 2-tailed log-rank tests compared OS based on early RECIST 1.1 response against each of the other criteria. A Cox proportional hazards model assessed response at follow-up exams as a time-varying covariate for OS. Results: We assessed 141 lesions in 55CT scans from 17 patients with urothelial metastasis, comparing VTV, RECIST, MASS, and Choi criteria, and volumetric measurements, for response assessment. Median follow-up was 4.5 months, range was 2–14 months. Only the VTV criteria demonstrated a statistical association with OS (p = 0.019; median OS 9.7 vs. 3.5 months). Conclusion: This pilot study suggests that VTV is a promising tool for assessing tumor response and predicting OS, using criteria that incorporate tumor volume and density in patients receiving antiangiogenic therapy for urothelial cancer. Larger studies are warranted to

  10. Quantum Partial Searching Algorithm of a Database with Several Target Items

    Institute of Scientific and Technical Information of China (English)

    ZHONG Pu-Cha; BAO Wan-Su; WEI Yun

    2009-01-01

    Choi and Korepin [Quantum Information Processing 6(2007)243] presented a quantum partial search algorithm of a database with several target items which can find a target block quickly when each target block contains the same number of target items. Actually, the number of target items in each target block is arbitrary. Aiming at this case, we give a condition to guarantee performance of the partial search algorithm to be performed and the number of queries to oracle of the algorithm to be minimized. In addition, by further numerical computing we come to the conclusion that the more uniform the distribution of target items, the smaller the number of queries.

  11. Analysis of myo-inositol hexakisphosphate hydrolysis by Bacillus phytase

    DEFF Research Database (Denmark)

    Kerovuo, J.; Rouvinen, J.; Hatzack, Frank-Andreas

    2000-01-01

    Phytic acid (myo-inositol hexakisphosphate, InsP(6)) hydrolysis by Bacillus phytase (PhyC) was studied. The enzyme hydrolyses only three phosphates from phytic acid. Moreover, the enzyme seems to prefer the hydrolysis of every second phosphate over that of adjacent ones. Furthermore, it is very...... a reaction mechanism different from that of other phytases. By combining the data presented in this study with (1) structural information obtained from the crystal structure of Bacillus amyloliquefaciens phytase [Ha, Oh, Shin, Kim, Oh, Kim, Choi and Oh (2000) Nat. Struct. Biol. 7, 147-153], and (2) computer...

  12. A Comparative Docking Study of Anibamine as the First Natural Product CCR5 Antagonist in CCR5 Homology Models

    OpenAIRE

    2009-01-01

    Anibamine, a novel pyridine quaternary alkaloid recently isolated from Aniba sp., has been found to effectively bind to the chemokine receptor CCR5 with an IC50 at 1 μM in competition with 125I-gp120, an HIV viral envelope protein binding to CCR5 with high affinity. Since CCR5, a G-protein-coupled receptor, is an essential co-receptor for the human immunodeficiency virus type I (HIV-1) entry to host cells, a CCR5 antagonist that inhibits the cellular entry of HIV-1 provides a new therapy choi...

  13. Organic NLO Polymers. 5. Homopolymerization of Indole Based NLO-phore: A Heterocycle Chi(2)NLO Main-Chain Polymer

    Science.gov (United States)

    1994-05-28

    Lackrltz" and Lee-Yin Liu 2J. 1 wje I Oi School of Chemical SA~giiaeuiat, Purdue Unioersity, Wesit NK InOR Laftbyet ,. A 479071Z26 cHOI, coa 9t Ti (Os3...o /co m. c~ Introduction The design and synthesis of nw NLO materials for i .. CbYt and bucyl optoacave device appli&ctons an be accomplished...through a 2 variety of schemne.’ Tin development of polymeric J" NLO 2Qj:Q1j’TJ materials has boen approached firom a variety od ceative Is on design

  14. Development of a Small Molecule P2X7R Antagonist as a Treatment for Acute SCI

    Science.gov (United States)

    2012-10-01

    Alexander disease. Ann Neurol 57:310–326. Liauw J, Hoang S, Choi M, Eroglu C, Sun GH, Percy M, Wildman-Tobriner B, Bliss T, Guzman RG, Barres BA...intercrossing to yield Aqp4−/− and Aqp4+/+ (WTs). For acute cortical slice experiments, we also used C57BL/6J pups from Jackson Laboratory as WT controls... Jackson Immunoresearch) were used at 1:250. After immunolabeling, the sections were counter- stained with DAPI (1:5,000, Invitrogen) for 10 min at room

  15. Some Connections between the Spherical and Parabolic Bases on the Cone Expressed in terms of the Macdonald Function

    Directory of Open Access Journals (Sweden)

    I. A. Shilin

    2014-01-01

    Full Text Available Computing the matrix elements of the linear operator, which transforms the spherical basis of SO(3,1-representation space into the hyperbolic basis, very recently, Shilin and Choi (2013 presented an integral formula involving the product of two Legendre functions of the first kind expressed in terms of  4F3-hypergeometric function and, using the general Mehler-Fock transform, another integral formula for the Legendre function of the first kind. In the sequel, we investigate the pairwise connections between the spherical, hyperbolic, and parabolic bases. Using the above connections, we give an interesting series involving the Gauss hypergeometric functions expressed in terms of the Macdonald function.

  16. Tick Surveillance of Small Mammals Captured in Gyeonggi and Gangwon Provinces, Republic of Korea, 2004-2008

    Science.gov (United States)

    2010-07-30

    histologically diagnosed tick infestation on the scalp of a Korean child. Korean Journal of Parasitology , 44, 157–161. Horak, I.G., Camicas, J.-L... Veterinary Science, 6, 327–334. Kim, H.C., Ko, S.J., Chong, S.T., Choi, C.Y., Nam, H.Y., Chae, H.Y., Klein, T.A., Sames, W.J., Robbins, R.G. & Chae...and Veterinary Entomology, 23, 15–20. Ko, J.H., Cho, D.Y., Chung, B.S. & Kim, S.I. (2002) Two human cases of tick bite caused by Ixodes nipponen- sis

  17. Strategies to improve compliance among oral contraceptive pill users: a review of the literature

    Directory of Open Access Journals (Sweden)

    Choi A

    2014-06-01

    Full Text Available Angela Choi, Angela DempseyDepartment of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USAAbstract: Oral contraceptive pills (OCPs remain the most commonly used reversible birth control method. Failure to adhere to daily pill taking and gaps in use are common and contribute to the risk of unintended pregnancy among OCP users. OCP compliance is influenced by a complex interplay of cognitive, behavioral, logistic, clinical, and social factors. This review outlines the evidence base for strategies that have been studied for their impact on OCP compliance.Keywords: adherence, continuation, unintended pregnancy, reminder system

  18. Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock

    Science.gov (United States)

    2011-01-01

    no. 1-2, pp. 73–76, 1999. [84] H. S. Park , S. G. Cho, C. K. Kim et al., “Heat shock protein Hsp72 is a negative regulator of apoptosis signal...1, pp. 474–481, 2010. [98] A. R. Kochenek, E. Y. Fukudome, J. S. Eleanor et al., “Phar- macological resuscitation attenuates MAP kinase pathway...inhibitors,” Journal of Neurochemistry, vol. 87, no. 2, pp. 407–416, 2003. [131] Y. Choi, S. K. Park , M. K. Hwan et al., “Histone deacetylase inhibitor

  19. Modelling of quantum information processing with Ehrenfest guided tra jectories: a case study

    CERN Document Server

    Ye, Sai-Yun; Serafini, Alessio

    2012-01-01

    We apply a numerical method based on multi-configurational Ehrenfest tra jectories, and demonstrate converged results for the Choi fidelity of an entangling quantum gate between two two-level systems interacting through a set of bosonic modes. We consider both spin-boson and rotating wave Hamiltonians, for various numbers of mediating modes (from 1 to 100), and extend our treatment to include finite temperatures. Our results apply to two-level impurities interacting with the same band of a photonic crystal, or to two distant ions interacting with the same set of motional degrees of freedom.

  20. Modeling of quantum-information processing with Ehrenfest guided trajectories: A case study with spin-boson-like couplings

    Science.gov (United States)

    Ye, Sai-Yun; Shalashilin, Dmitrii; Serafini, Alessio

    2012-09-01

    We apply a numerical method based on multiconfigurational Ehrenfest trajectories and demonstrate converged results for the Choi fidelity of an entangling quantum gate between two two-level systems interacting through a set of bosonic modes. We consider both spin-boson and rotating-wave Hamiltonians for various numbers of mediating modes (from 1 to 100) and extend our treatment to include finite temperatures. Our results apply to two-level impurities interacting with the same band of a photonic crystal or to two distant ions interacting with the same set of motional degrees of freedom.

  1. Multi-Scale Microstructure and Mechanical Properties of High Carbon Eutectic Tantalum Carbide Reinforced with Carbon Nanotubes

    Science.gov (United States)

    2012-07-02

    of 5 vol.% of MoSi2 helped in densification up to 98% [29]. Hafnium carbide [22,23] and zirconium carbide [23] powders have been successfully...244–250. [2] O. Khyzhun, J. Alloys Compd. 259 (1997) 47–58. [3] J.G. Choi, Appl. Catal. A 184 (1999) 189–201. [4] R.W. Bartlett, C.W. Smith, J. Appl...Hulbert, A. Anders, J. Andersson, E.J. Lavernia, A.K. Mukherjee, Scripta Mater. 60 (2009) 835–838. [20] F. Monteverde, J. Alloys Compd. 428 (2007

  2. Multicharged Ion Promoted Desorption (MIPD) of Reaction Co-Products

    Science.gov (United States)

    2015-02-13

    nanodiamonds by single impacts of highly charged ions upon graphite”, Applied Physics Letters 79, 3866(2001). [3] S-K. Koh, S-K. Song, W-K. Choi, H-J...for singly charged ions surface processing of the same substrate. (a) Papers published in peer-reviewed journals (N/A for none) Enter List of papers...structure formation at single impact sites for multiply charged ions . A direct comparison of our result to other ion irradiation studies which indicate

  3. Criminal Sovereignty: Understanding North Korea’s Illicit International Activities

    Science.gov (United States)

    2010-03-01

    of the contraband. The overhead for the smuggling of these “fake” cigarettes is very low. According to former State Department official David Asher ...stories/macau. north.korea/index.html. 11. Jay Solomon and Hae Won Choi, “Money Trail: In North Korea, Secret Cash Hoard Props Up Regime,” Wall Street...Times, April 6, 2006, available from www.latimes.com/news/ printedition/la-fg-macao6apr06,1,7483991.story. 15. Spaeth. 16. Jay Solomon and Jason

  4. Equilibration Dynamics of Strongly Interacting Bosons in 2D Lattices with Disorder

    Science.gov (United States)

    Yan, Mi; Hui, Hoi-Yin; Rigol, Marcos; Scarola, V. W.

    2017-08-01

    Motivated by recent optical lattice experiments [J.-y. Choi et al., Science 352, 1547 (2016), 10.1126/science.aaf8834], we study the dynamics of strongly interacting bosons in the presence of disorder in two dimensions. We show that Gutzwiller mean-field theory (GMFT) captures the main experimental observations, which are a result of the competition between disorder and interactions. Our findings highlight the difficulty in distinguishing glassy dynamics, which can be captured by GMFT, and many-body localization, which cannot be captured by GMFT, and indicate the need for further experimental studies of this system.

  5. Pratiques sociales en formation à distance

    OpenAIRE

    Clément Dussarps; Didier Paquelin

    2015-01-01

    L’abandon en formation ouverte et à distance (FOAD) constitue un enjeu important tant pour les apprenants que pour les organismes de formation, que ce soit pour des raisons économiques, sociales, ou encore d’image de soi ou publique (Sauvé, 2012). L’un des éléments clés de l’abandon semble être la solitude vécue par les apprenants (Glikman, 2002, p. 242). Ce sentiment de solitude et l’abandon semblent peu dépendants de facteurs socio-démographiques (sexe, âge, etc.) (Park et Choi, 2009). Face...

  6. L'entreprenariat associatif

    OpenAIRE

    Madina Rival

    2008-01-01

    Le développement des associations conduit à a multiplication des pratiques issues de l'entreprises dans ces organisations a priori sans but lucratif. Cette communication cherche à s'interroger sur les manifestations profondes de telles évolutions. L'entreprise est caractérisée depuis Weber par la figure de l'entrepreneur et depuis Schumpeter par l'activité d'entreprenariat. Quelles formes peut prendre l'émergence de l'entreprenariat associatif ?Pour répondre à cette question, nous avons chois...

  7. Sputter Deposited TiOx Thin-Films as Electron Transport Layers in Organic Solar Cells

    DEFF Research Database (Denmark)

    Mirsafaei, Mina; Bomholt Jensen, Pia; Lakhotiya, Harish

    2017-01-01

    of Materials Chemistry 2010, 20 (13), 2499-2512. 2. Kim, J.; Kim, G.; Choi, Y.; Lee, J.; Park, S. H.; Lee, K., Light-soaking issue in polymer solar cells: Photoinduced energy level alignment at the sol-gel processed metal oxide and indium tin oxide interface. Journal of Applied Physics 2012, 111 (11), 114511.......The use of interfacial layers in organic solar cells has been investigated intensively over the past years, as it has a strong impact on both the power conversion efficiency and stability of the devices. Among the systems investigated are for example alkali salts, ionic liquids, neutral polymers...

  8. The Time-Frequency Characteristics of Pulse Propagation Through Plasma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    In this paper, propagated δ pulses through different distance of Plasma are calculated, and their time-frequency characteristics are studied using CWD (Choi-William distrilution). It is found that several horizontal spectra appear at early arrival time like discrete spectruml at last time a hyperbolic curve lies in the time-frequency spectrum which corresponds to the frequency-group delay curve of plasma. To understand the time-frequency, the property of a signal is helpful for obtaining the plasma parameters.

  9. Reference: 710 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 710 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18162593i Jung Choonkyun et al. 2008 Fe...ic stress tolerance of transgenic Arabidopsis overexpressing AtMYB44 was conferred by reduced expression of ...naling. Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic... Arabidopsis. 2 623-35 18162593 2008 Feb Plant physiology Cheong Jong-Joo|Choi Yang Do|Han Sang Won|Jung Choonkyun|Kim Chung Ho|Koo Yeon Jong|Nahm Baek Hie|Seo Jun Sung|Song Sang Ik

  10. On the M/G/1 queueing system with multiclass customers and fixed feedback

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qi-zhi

    2008-01-01

    The M/G/1 queueing system with multiclass customer arrivals, fixed feedback, and first come first served policy is considered, where different classes of customers have different arrival rates, service-time distributions, and feedback numbers. The joint probability generation function of queue size of each class and the Laplace-Stieltjes transform of the total sojourn time of a customer in each class are presented, which extended the results obtained by Choi B D. The mean queue size of each class and mean total sojourn time of a customer in each class are obtained with this result. The results can be used in computer and communication networks for their performance analysis.

  11. Magnetothermopower in unconventional charge density wave ground state of α-(BEDT-TTF){_2}KHg(SCN){_4}

    Science.gov (United States)

    Dóra, B.; Maki, K.; Virosztek, A.; Ványolos, A.

    2004-04-01

    We have investigated theoretically the thermoelectric power and the Nernst effect in unconventional density waves (UDW). Due to the presence of magnetic field, Landau levels are formed, and the low energy excitations change from gapless to gapped. The present results account consistently for the recent data of magnetothermopower in α-(BEDT-TTF)2KHg(SCN)4 obtained by Choi et al. (Phys. Rev. B, 65, 205119 (2002)). This confirms further our identification of low temperature phase (LTP) in this salt as UCDW. Key words. density waves, α-(BEDT-TTF)2KHg(SCN)4, thermoelectric power.

  12. Magnetothermopower and Nernst effect in unconventional charge density waves

    Science.gov (United States)

    Dóra, Balázs; Maki, Kazumi; Ványolos, András; Virosztek, Attila

    2003-12-01

    Recently we have shown that the striking angular dependent magnetoresistance in the low-temperature phase (LTP) of α-(BEDT-TTF)2KHg(SCN)4 is consistently described in terms of unconventional charge density wave (UCDW). Here we investigate theoretically the thermoelectric power and the Nernst effect in unconventional density wave (UDW). The present results account consistently for the recent data of magnetothermopower in α-(BEDT-TTF)2KHg(SCN)4 obtained by Choi et al. [Phys. Rev. B 65, 205119 (2002)]. This confirms further our identification of LTP in this salt as UCDW. We propose also that the Nernst effect provides a clear signature of UDW.

  13. Generalized Optimal-State-Constraint Extended Kalman Filter (OSC-EKF)

    Science.gov (United States)

    2017-02-01

    Materials Research Directorate, ARL Kevin Eckenhoff and Guoquan Huang Department of Mechanical Engineering, University of Delaware , Newark, DE...REPORT    b. ABSTRACT    c. THIS PAGE    19b. TELEPHONE NUMBER (Include area code)   Standard Form 298 (Rev. 8/98)    Prescribed by ANSI  Std . Z39.18...INSTITUTE OF TECHNOL- OGY M COSTELLO J ROGERS 1 (PDF) UNIVERSITY OF DELAWARE G HUANG 7 (PDF) RDECOM ARDEC J CHOI R DECKER M GUEVARA P MAGNOTTI T RECCHIA C

  14. Combination Therapy for Radiation-Induced Bone Marrow Aplasia in Nonhuman Primates Using Synthokine SC-55494 and Recombinant Human Granulocyte Colony-Stimulating Factor

    Science.gov (United States)

    1996-05-15

    treated animals ( P < .05). t Significantly different from rhG-CSF ( P < .05). Stain; Ames Automated Slide Stainer , Elkhart, IN). Baseline levels...Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA, Sprecher CA, Blumber H, Johnson R, h n k a r d D, Ching AFT, Mathewes SL, Balley MC, Forstrom...Swift S, Johnson MJ, Hsu RY, Parker VP, Suggs S, Skrine ID, Merewether LA, Clogston C, Hsu E, Hokom MM, Homkohl A, Choi E, Pangeliana M, Sun Y, Mar

  15. Time-frequency analysis of the sea state with the "Andrea" freak wave

    Science.gov (United States)

    Cherneva, Z.; Guedes Soares, C.

    2014-02-01

    The non-linear and non-stationary properties of a special field wave record are analyzed with the Wigner spectrum with the Choi-Williams kernel. The wave time series, which was recorded at the Ekofisk complex in the Central North Sea at 00:40 UTC on 9 November 2007, contains an abnormally high wave known as "Andrea" wave. The ability of the Wigner spectrum to reveal the wave energy distribution in frequency and time is demonstrated. The results are compared with previous investigations for different sea states and also the state with the abnormal Draupner's New Year wave.

  16. Time-frequency analysis of the sea state with the Andrea freak wave

    Science.gov (United States)

    Cherneva, Z.; Guedes Soares, C.

    2014-12-01

    The nonlinear and nonstationary properties of a special field wave record are analysed with the Wigner spectrum with the Choi-Williams kernel. The wave time series, which was recorded at the Ekofisk complex in the central North Sea at 00:40 UTC (universal time coordinated) on 9 November 2007, contains an abnormally high wave known as the "Andrea" wave. The ability of the Wigner spectrum to reveal the wave energy distribution in frequency and time is demonstrated. The results are compared with previous investigations for different sea states and also the state with Draupner's abnormal "New Year" wave.

  17. Metabolomic analysis of methyl jasmonate-Induced triterpenoid production in the medicinal herb Centella asiatica (L.) Urban

    CSIR Research Space (South Africa)

    James, TJ

    2013-04-01

    Full Text Available . Palazón, J.; Bonfill, R.M.C.M.; Mallol, A.; Moyano, E.; Morales, C.; Pinol, M.T. Elicitation of different Panax ginseng transformed root phenotypes for an improved ginsenoside production. Plant Physiol. Biochem. 2003, 41, 1019–1025. 22. Fritz, V... 19. Kim, O.T.; Kim, S.H.; Ohyama, K.; Muranaka, T.; Choi, Y.E.; Lee, H.Y.; Kim, M.Y.; Hwang, B. Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. Plant Cell...

  18. Network Intrusion Dataset Assessment

    Science.gov (United States)

    2013-03-01

    Science, pages 576–585. Springer Berlin / Heidelberg, June 2010. • Jing Xiao-Pei and Wang Hou -Xiang. “A new immunity intrusion detection model based on...2008. • Hongying Zheng, Meiju Hou , and Yu Wang. “An efficient hybrid clustering-PSO algorithm for anomaly intrusion detection.” Journal of Software...Technology, 2(6):1790– 1799, 2010. [34] Lee, Suchul, Hyunchul Kim, Dhiman Barman, Sungryoul Lee, Chong -kwon Kim, Ted Kwon, and Yanghee Choi. “NeTraMark: a

  19. DMPD: Toll-like receptor signal transduction. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available (4):421-38. Pathway - PNG File (.png) SVG File (.svg) HTML File (.html) CSML File (.csml) Open .csml file with CIOPlayer Open .csm... M, Lee G, Choi S. Exp Mol Med. 2007 Aug 31;39(4):421-38. (.png) (.svg) (.html) (.csml) Show Toll-like recep...l file with CIOPlayer - ※CIO Playerのご利用上の注意 Open .csml file with CIO Open .csml file with CIO - ※CIOのご利用上の注意 ...

  20. Prevalence of undiagnosed airflow obstruction among people with a history of smoking in a primary care setting

    OpenAIRE

    2016-01-01

    Sau Nga Fu,1 Wai Cho Yu,2 Carlos King-Ho Wong,3 Margaret Choi-Hing Lam1 1Department of Family Medicine and Primary Health Care, Kowloon West Cluster, Hospital Authority, 2Department of Medicine and Geriatrics, Princess Margaret Hospital, 3Department of Family Medicine and Primary Care, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR Purpose: The purpose of this study was to define the prevalence of undiagnosed airflow obstruction (AO) among subjects with a history of...

  1. Pratiques sociales en formation à distance

    Directory of Open Access Journals (Sweden)

    Clément Dussarps

    2015-10-01

    Full Text Available L’abandon en formation ouverte et à distance (FOAD constitue un enjeu important tant pour les apprenants que pour les organismes de formation, que ce soit pour des raisons économiques, sociales, ou encore d’image de soi ou publique (Sauvé, 2012. L’un des éléments clés de l’abandon semble être la solitude vécue par les apprenants (Glikman, 2002, p. 242. Ce sentiment de solitude et l’abandon semblent peu dépendants de facteurs socio-démographiques (sexe, âge, etc. (Park et Choi, 2009. Face...

  2. ETS transcription factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development, Injury and Regeneration.

    Science.gov (United States)

    Zhao, Haiyong; Xu, Canxin; Lee, Taejin; Liu, Fang; Choi, Kyunghee

    2016-12-27

    Editorial Notice: ETS transcription factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development, Injury and Regeneration. Haiyong Zhao, Canxin Xu, Taejin Lee, Fang Liu and Kyunghee Choi. Accepted manuscript online: 27 DEC 2016 | DOI: 10.1002/dvdy.24483. The above article, published as an Accepted Article online on Dec 27, 2016, in Wiley Online Library (wileyonlinelibrary.com), has been temporarily withdrawn by agreement between the authors, the journal Editor in Chief, Parker B. Antin, and Wiley Periodicals, Inc. The temporary withdrawal has been agreed due to a delay in publication of an article which is referenced in the above manuscript. This article is protected by copyright. All rights reserved.

  3. Suppression and enhancement of transcriptional noise by DNA looping

    Science.gov (United States)

    Vilar, Jose M. G.; Saiz, Leonor

    2014-06-01

    DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi, L. Cai, K. Frieda, and X. S. Xie, Science 322, 442 (2008), 10.1126/science.1161427].

  4. United States Army in the Korean War: EBB and Flow, November 1950-July 1951

    Science.gov (United States)

    1990-01-01

    been to return to tile F-51 Iislhed, BombeI)r Comma~nd under iMaj . with its longer ranlge and its capacity Gen. Emmett O’DonnellJr.. to handle For low...Divisions, ROI{. Chief of Staff. NIKPA. See Lee Sang Cho, IMaj . Gen.; 3d, 9t11. Nam 11, Lt. Gen. Choi Yong Ilece, Bi g. Geni.: 266, 268 See also 1)ivi- Chief...10Of1h. KomiC. Republic of. Air Force: 36n Lee I-long Stin. Mitj.: 332 Korea. Republic of. Ai my: 23. 26, 27. 1-19. 15 1. 162. 1.ee Sang Clio, IMaj

  5. Bloch oscillations and mean-field effects of Bose-Einstein condensates in 1D optical lattices.

    Science.gov (United States)

    Morsch, O; Müller, J H; Cristiani, M; Ciampini, D; Arimondo, E

    2001-10-01

    We have loaded Bose-Einstein condensates into one-dimensional, off-resonant optical lattices and accelerated them by chirping the frequency difference between the two lattice beams. For small values of the lattice well depth, Bloch oscillations were observed. Reducing the potential depth further, Landau-Zener tunneling out of the lowest lattice band, leading to a breakdown of the oscillations, was also studied and used as a probe for the effective potential resulting from mean-field interactions as predicted by Choi and Niu [Phys. Rev. Lett. 82, 2022 (1999)]. The effective potential was measured for various condensate densities and trap geometries, yielding good qualitative agreement with theoretical calculations.

  6. On the Ruled surfaces in Minkowski 3-space R13

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Izumiya and Takeuchi (2003) obtained some characterizations for Ruled surfaces. Turgut and Hacissalihoglu (1998) defined timelike Ruled surfaces and obtained some characterizations in timelike Ruled surfaces. Choi (1995) and Jung and Pak (1996) studied Ruled surfaces. This study uses the method in (Izumiya and Takeuchi, 2003) to investigate cylindrical helices and Bertrand curves as curves on timelike Ruled surfaces in Minkowski 3-space R13. We have studied singularities of the rectifying developable (surface) of a timelike curve. We observed that the rectifying developable along a timelike curve α is non-singular if and only if α is a cylindrical helice. In this case the rectifying developable is a cylindrical surface.

  7. Phenotype-gene: 638 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 638 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u3ria224u1635i serrated vascu...lar leaf for AT5G37055 Choi Kyuha et al. 2007 May. Development 134(10):1931-41. http://metadb.riken.jp/db/Sc...iNetS_ria224i/cria224u4ria224u17470967i serrated vascular leaf http://metadb.riken.jp/db/SciNetS_ria224i/cria224u1ria224u975i AT5G37055

  8. Exploring Alkaline Stable Organic Cations for Polymer Hydroxide Exchange Membranes

    Science.gov (United States)

    2015-04-29

    2012, 219, 272- 279. [82] C. Chen, A. R. Hess , A. R. Jones, X. Liu, G. D. Barber, T. E. Mallouk, H. R. Allcock, Macromolecules 2012, 45, 1182-1189... Herman , J. R. Varcoe, Energy & Environmental Science 2012, 5, 8584-8597. [176] M. A. Hossain, Y. Lim, S. Lee, H. Jang, S. Choi, Y. Jeon, S. Lee, H. Ju, W...Catalysis a-Chemical 2007, 270, 123-126. [241] H. Herman , R. C. T. Slade, J. R. Varcoe, Journal of Membrane Science 2003, 218, 147-163. [242] G. G

  9. Gel Spun PAN/CNT Based Carbon Fibers with Honey-Comb Cross-Section

    Science.gov (United States)

    2013-11-13

    30 37 100 / -50 Could not obtain fiber due to uneven extrusion and dripping of polymer solution 3 15/30 150 60 / 40 37 100 / -50 4 15/30 150 70...on structure, processing, and properties of polymer /CNT composite films and fibers were also conducted. Results of these studies are well documented...Structure, and Properties of Carbon Fibers”, Polymer Reviews, 52, 234-258 (2012). DOI: 10.1080/15583724.2012.705410. 9. Y. Liu, Y. H. Choi, H. G. Chae, P

  10. Uncooled Split-off Quantum Infrared Sensors for 3-5 Micron Imaging Applications

    Science.gov (United States)

    2012-12-20

    Perera, H. C. Liu, M. Buchanan, Z. R. Wasilewski , K. K. Choi, P. Wijewarnasuriya. Light-hole and heavy-hole transitions for high-temperature long...Y.F. Lao, S.P. Khanna, L.H. Li, E.H. Linfield, Z.R. Wasilewski , M. Buchanan, X.H. Wu, H.C. Liu. Effects of graded barriers on the operation of split...Pitigala, S. G. Matsik, A. G. U. Perera, S. P. Khanna, L. H. Li, E. H. Linfield, Z. R. Wasilewski , M. Buchanan, H. C. Liu. Photovoltaic infrared detection

  11. Derivation of asymptotic two-dimensional time-dependent equations for ocean wave propagation

    CERN Document Server

    Lannes, David

    2007-01-01

    A general method for the derivation of asymptotic nonlinear shallow water and deep water models is presented. Starting from a general dimensionless version of the water-wave equations, we reduce the problem to a system of two equations on the surface elevation and the velocity potential at the free surface. These equations involve a Dirichlet-Neumann operator and we show that all the asymptotic models can be recovered by a simple asymptotic expansion of this operator, in function of the shallowness parameter (shallow water limit) or the steepness parameter (deep water limit). Based on this method, a new two-dimensional fully dispersive model for small wave steepness is also derived, which extends to uneven bottom the approach developed by Matsuno \\cite{matsuno3} and Choi \\cite{choi}. This model is still valid in shallow water but with less precision than what can be achieved with Green-Naghdi model, when fully nonlinear waves are considered. The combination, or the coupling, of the new fully dispersive equati...

  12. New developments in the management of congenital Factor XIII deficiency [Corrigendum

    Directory of Open Access Journals (Sweden)

    Fadoo Z

    2013-07-01

    Full Text Available Fadoo Z, Merchant Q, Rehman KA. Journal of Blood Medicine. 2013;4:65–73.On page 67 the legend of Figure 1 incorrectly states "Reprinted from Song JW, Choi JR, Song KS, Rhee JH. Plasma factor XIII activity in patients with disseminated intravascular coagulation. Yonsei Med J. 2006;47(2:196–200." The correct statement is "Reprinted from Muszbek L, Bagoly Z, Cairo A, Peyvandi F. Novel aspects of factor XIII deficiency. Curr Opin Hematol. 2011;18(5:366–372."On page 69 the legend of Table 1 states "Reprinted from Song JW, Choi JR, Song KS, Rhee JH. Plasma factor XIII activity in patients with disseminated intravascular coagulation. Yonsei Med J. 2006;47(2:196–200." The correct statement is "Reprinted from Kohler HP, Ichinose A, Seitz R, Ariens RA, Muszbek L; Factor XIII and fibrinogen SSC subcommittee of the ISTH. Diagnosis and classification of factor XIII deficiencies. J Thromb Haemost. 2011;9(7:1404–1406." Read the original article

  13. Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent.

    Science.gov (United States)

    Kapuścik, Aleksandra; Hrouzek, Pavel; Kuzma, Marek; Bártová, Simona; Novák, Petr; Jokela, Jouni; Pflüger, Maren; Eger, Andreas; Hundsberger, Harald; Kopecký, Jiří

    2013-11-25

    Aeruginosin-865 (Aer-865), isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety, and is the first aeruginosin to be found in the genus Nostoc. Mass spectrometry, chemical and spectroscopic analysis as well as one- and two-dimensional NMR and chiral HPLC analysis of Marfey derivatives were applied to determine the peptidic sequence: D-Hpla, D-Leu, 5-OH-Choi, Agma, with hexanoic and mannopyranosyl uronic acid moieties linked to Choi. We used an AlphaLISA assay to measure the levels of proinflammatory mediators IL-8 and ICAM-1 in hTNF-α-stimulated HLMVECs. Aer-865 showed significant reduction of both: with EC50 values of (3.5±1.5) μg mL(-1) ((4.0±1.7) μM) and (50.0±13.4) μg mL(-1) ((57.8±15.5) μM), respectively. Confocal laser scanning microscopy revealed that the anti-inflammatory effect of Aer-865 was directly associated with inhibition of NF-κB translocation to the nucleus. Moreover, Aer-865 did not show any cytotoxic effect. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Gene-expression profiling and not immunophenotypic algorithms predicts prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy.

    Science.gov (United States)

    Gutiérrez-García, Gonzalo; Cardesa-Salzmann, Teresa; Climent, Fina; González-Barca, Eva; Mercadal, Santiago; Mate, José L; Sancho, Juan M; Arenillas, Leonor; Serrano, Sergi; Escoda, Lourdes; Martínez, Salomé; Valera, Alexandra; Martínez, Antonio; Jares, Pedro; Pinyol, Magdalena; García-Herrera, Adriana; Martínez-Trillos, Alejandra; Giné, Eva; Villamor, Neus; Campo, Elías; Colomo, Luis; López-Guillermo, Armando

    2011-05-05

    Diffuse large B-cell lymphomas (DLBCLs) can be divided into germinal-center B cell-like (GCB) and activated-B cell-like (ABC) subtypes by gene-expression profiling (GEP), with the latter showing a poorer outcome. Although this classification can be mimicked by different immunostaining algorithms, their reliability is the object of controversy. We constructed tissue microarrays with samples of 157 DLBCL patients homogeneously treated with immunochemotherapy to apply the following algorithms: Colomo (MUM1/IRF4, CD10, and BCL6 antigens), Hans (CD10, BCL6, and MUM1/IRF4), Muris (CD10 and MUM1/IRF4 plus BCL2), Choi (GCET1, MUM1/IRF4, CD10, FOXP1, and BCL6), and Tally (CD10, GCET1, MUM1/IRF4, FOXP1, and LMO2). GEP information was available in 62 cases. The proportion of misclassified cases by immunohistochemistry compared with GEP was higher when defining the GCB subset: 41%, 48%, 30%, 60%, and 40% for Colomo, Hans, Muris, Choi, and Tally, respectively. Whereas the GEP groups showed significantly different 5-year progression-free survival (76% vs 31% for GCB and activated DLBCL) and overall survival (80% vs 45%), none of the immunostaining algorithms was able to retain the prognostic impact of the groups (GCB vs non-GCB). In conclusion, stratification based on immunostaining algorithms should be used with caution in guiding therapy, even in clinical trials.

  15. 分类分析中基于信息论准则的特征选取%Feature Selection for Classificatory Analysis Based on Information-theoretic Criteria

    Institute of Scientific and Technical Information of China (English)

    黄金杰; 吕宁; 李双全; 蔡云泽

    2008-01-01

    Feature selection aims to reduce the dimensionality of patterns for classificatory analysis by selecting the most informative instead of irrelevant and/or redundant features. In this study, two novel information-theoretic measures for feature ranking are presented: one is an improved formula to estimate the conditional mutual information between the candidate feature fi and the target class C given the subset of selected features S, i. e., I(C; fi|S), under the assumption that information of features is distributed uniformly; the other is a mutual information (MI) based constructive criterion that is able to capture both irrelevant and redundant input features under arbitrary distributions of information of features. With these two measures, two new feature selection algorithms,called the quadratic MI-based feature selection (QMIFS) approach and the MI-based constructive criterion (MICC) approach,respectively, are proposed, in which no parameters like β in Battiti's MIFS and (Kwak and Choi)'s MIFS-U methods need to be preset. Thus, the intractable problem of how to choose an appropriate value for β to do the tradeoff between the relevance to the target classes and the redundancy with the already-selected features is avoided completely. Experimental results demonstrate the good performances of QMIFS and MICC on both synthetic and benchmark data sets.

  16. Can the masses of isolated planetary-mass gravitational lenses be measured by terrestrial parallax?

    CERN Document Server

    Freeman, M; Abe, F; Albrow, M D; Bennett, D P; Bond, I A; Botzler, C S; Bray, J C; Cherrie, J M; Christie, G W; Dionnet, Z; Gould, A; Han, C; Heyrovsky, D; McCormick, J M; Moorhouse, D M; Muraki, Y; Natusch, T; Rattenbury, N J; Skowron, J; Sumi, T; Suzuki, D; Tan, T -G; Tristram, P J; Yock, P C M

    2014-01-01

    Recently Sumi et al. (2011) reported evidence for a large population of planetary-mass objects (PMOs) that are either unbound or orbit host stars in orbits > 10 AU. Their result was deduced from the statistical distribution of durations of gravitational microlensing events observed by the MOA collaboration during 2006 and 2007. Here we study the feasibility of measuring the mass of an individual PMO through microlensing by examining a particular event, MOA-2011-BLG-274. This event was unusual as the duration was short, the magnification high, the source-size effect large and the angular Einstein radius small. Also, it was intensively monitored from widely separated locations under clear skies at low air masses. Choi et al. (2012) concluded that the lens of the event may have been a PMO but they did not attempt a measurement of its mass. We report here a re-analysis of the event using re-reduced data. We confirm the results of Choi et al. and attempt a measurement of the mass and distance of the lens using the...

  17. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

    Directory of Open Access Journals (Sweden)

    Ferrari F

    2011-04-01

    Full Text Available Flora Ferrari1, Simonetta Fiorentino1, Laura Mennuni1, Paolo Garofalo1, Ornella Letari1, Stefano Mandelli2, Antonio Giordani3, Marco Lanza1, Gianfranco Caselli11Department of Pharmacology and Toxicology; 2Department of Medicinal Chemistry; 3R&D Chemistry Drug Development and OS, Rottapharm S.p.A., Monza (MB, ItalyAbstract: Two decades of investigations have failed to unequivocally clarify the functions and the molecular nature of imidazoline-2 receptors (I2R. However, there is robust pharmacological evidence for the functional modulation of monoamino oxidase (MAO and other important enzyme activities by I2 site ligands. Some compounds of this class proved to be active experimental tools in preventing both experimental pain and opioid tolerance and dependence. Unfortunately, even though these compounds bind with high potency to central I2 sites, they fail to represent a valid clinical opportunity due to their pharmacokinetic, selectivity or side-effects profile. This paper presents the preclinical profile of a novel I2 ligand (2-phenyl-6-(1H-imidazol-1ylquinazoline; [CR4056] that selectively inhibits the activity of human recombinant MAO-A in a concentration-dependent manner. A sub-chronic four day oral treatment of CR4056 increased norepinephrine (NE tissue levels both in the rat cerebral cortex (63.1% ± 4.2%; P<0.05 and lumbar spinal cord (51.3% ± 6.7%; P < 0.05. In the complete Freund's adjuvant (CFA rat model of inflammatory pain, CR4056 was found to be orally active (ED50 = 5.8 mg/kg, by mouth [p.o.]. In the acute capsaicin model, CR4056 completely blocked mechanical hyperalgesia in the injured hind paw (ED50 = 4.1 mg/kg, p.o.; ED100 = 17.9 mg/kg, p.o.. This effect was dose-dependently antagonized by the non-selective imidazoline I2/α2 antagonist idazoxan. In rat models of neuropathic pain, oral administration of CR4056 significantly attenuated mechanical hyperalgesia and allodynia. In summary, the present study suggests a novel

  18. Medicinal clays improve the endurance of loaded inspiratory muscles in COPD: a randomized clinical trial of nonpharmacological treatment

    Directory of Open Access Journals (Sweden)

    Baldi S

    2015-10-01

    Full Text Available Simonetta Baldi,1 Gian Domenico Pinna,2 Claudio Bruschi,1 Fabrizio Caldara,3 Roberto Maestri,2 Elena Dacosto,1 Antonella Rezzani,1 Ermanno Popovich,1 Ezio Bellinzona,1 Paola Crotti,1 Silvia Montemartini,1 Claudio Fracchia1 1Department of Pneumology, 2Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation, Istituto Di Ricovero e Cura a Carattere Scientifico, Montescano (Pavia, 3Center of Thermal Studies Pietro d’Abano, AbanoTerme, Padua, Italy Background: Inspiratory resistive breathing (IRB challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an interleukin 6 (IL-6–dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in chronic obstructive pulmonary disease (COPD is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET and plasma IL-6 concentration following an IRB challenge.Methods: This study was a randomized, parallel-group, unblinded clinical trial in a single-center setting. Forty-two patients (aged 42–76 years suffering from mild to severe COPD participated in this study. Both groups completed 12 sessions of the mud bath therapy (MBT (n=22 or leisure thermal activity (LTA (n=19 in a thermal spa center in Italy. Pre- and postintervention spirometry, maximum inspiratory pressure, and plasma mediators were obtained and ET and endurance oxygen expenditure (VO2Endur were measured following IRB challenge at 40% of maximum inspiratory pressure.Results: There was no difference in ΔIL-6 between the intervention groups. But, IRB challenge increased cytokine IL-6 plasma levels systematically. The effect size was small. A statistically significant treatment by IRB challenge effect existed in ET, which significantly increased in the MBT group (P=0.003. In analysis of covariance treatment by IRB challenge analysis with LnVO2

  19. The origins of phagocytosis and eukaryogenesis

    Directory of Open Access Journals (Sweden)

    Wolf Yuri I

    2009-02-01

    eventually became the mitochondrion. The acquisition of the endosymbiont triggered eukaryogenesis, in particular, the emergence of the endomembrane system that eventually led to the evolution of modern-type phagocytosis, independently in several eukaryotic lineages. Reviewers This article was reviewed by Simonetta Gribaldo, Gaspar Jekely, and Pierre Pontarotti. For the full reviews, please go to the Reviewers' Reports section.

  20. Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer

    Directory of Open Access Journals (Sweden)

    Susini T

    2014-11-01

    Full Text Available Tommaso Susini,1 Barbara Berti,1 Carlo Carriero,1 Ketty Tavella,2 Jacopo Nori,3 Ermanno Vanzi,3 Cecilia Molino,1 Mariarosaria Di Tommaso,1 Marco Santini,1 Valeria Saladino,4 Simonetta Bianchi4 1Department of Health Science, Gynecology Section, 2Department of Health Science, Chemotherapy Section, University of Florence, Italy; 3Diagnostic Senology Unit, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; 4Department of Surgery and Translational Medicine, Pathology Unit, University of Florence, Italy Purpose: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A and transducin-like enhancer of split 3 (TLE3 as predictive markers of response to therapy with anthracyclines and taxanes. Materials and methods: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. Results: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%, with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06; negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07. A higher reduction in tumor diameter (P=0.03 was also found for tumors that were concurrently TLE3-negative and TOP2A

  1. Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

    Directory of Open Access Journals (Sweden)

    Simonetta Baldi

    2010-02-01

    Full Text Available Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, Paolo Poggi, Angelo De Martini, Claudio BruschiDepartment of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I.R.C.C.S. Pavia, ItalyBackground: Fat-free mass (FFM depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD. To date, the role of essential amino acid supplementation (EAAs in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation.Methods: 28 COPD patients with dynamic weight loss > 5% over the last 6 months were randomized to receive EAAs embedded in a 12-week rehabilitation program (EAAs group n = 14, or to the same program without supplementation (C group n = 14. Primary outcome measures were changes in body weight and FFM, using dual X-ray absorptiometry (DEXA.Results: At the 12th week, a body weight increment occurred in 92% and 15% of patients in the EAAs and C group, respectively, with an average increase of 3.8 ± 2.6 kg (P = 0.0002 and −0.1 ± 1.1 kg (P = 0.81, respectively. A FFM increment occurred in 69% and 15% of EAAs and C patients, respectively, with an average increase of 1.5 ± 2.6 kg (P = 0.05 and −0.1 ± 2.3 kg (P = 0.94, respectively. In the EAAs group, FFM change was significantly related to fasting insulin (r2 0.68, P < 0.0005, C-reactive protein (C-RP (r2 = 0.46, P < 0.01, and oxygen extraction tension (PaO2x (r2 = 0.46, P < 0.01 at end of treatment. These three variables were highly correlated in both groups (r > 0.7, P < 0.005 in all tests.Conclusions: Changes in FFM promoted by EAAs are related to cellular energy and tissue oxygen availability in depleted COPD. Insulin, C-RP, and PaO2x must be regarded as clinical markers of an amino acid-stimulated signaling to FFM accretion.Keywords: COPD, pulmonary rehabilitation, branched chain amino acids, insulin, systemic

  2. In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

    Directory of Open Access Journals (Sweden)

    Gelardi M

    2016-04-01

    Full Text Available Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A and 23 were sensitized only to ragweed pollen (group B. In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups

  3. Latent class analysis on internet and smartphone addiction in college students

    Directory of Open Access Journals (Sweden)

    Mok JY

    2014-05-01

    Full Text Available Jung-Yeon Mok,1 Sam-Wook Choi,1,2 Dai-Jin Kim,3 Jung-Seok Choi,4 Jaewon Lee,2 Heejune Ahn,5 Eun-Jeung Choi,6 Won-Young Song7 1Eulji Addiction Institute, Eulji University, Seoul, South Korea; 2Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea; 3Department of Psychiatry, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea; 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea; 5Department of Electrical and Information Engineering, SeoulTech, Seoul, South Korea; 6Department of Social Welfare, Dongshin University, Naju, South Korea; 7Department of Counseling and Psychotherapy, Konyang University, Nonsan, South Korea Purpose: This study aimed to classify distinct subgroups of people who use both smartphone and the internet based on addiction severity levels. Additionally, how the classified groups differed in terms of sex and psychosocial traits was examined. Methods: A total of 448 university students (178 males and 270 females in Korea participated. The participants were given a set of questionnaires examining the severity of their internet and smartphone addictions, their mood, their anxiety, and their personality. Latent class analysis and ANOVA (analysis of variance were the statistical methods used. Results: Significant differences between males and females were found for most of the variables (all P<0.05. Specifically, in terms of internet usage, males were more addicted than females (P<0.05; however, regarding smartphone, this pattern was reversed (P<0.001. Due to these observed differences, classifications of the subjects into subgroups based on internet and smartphone addiction were performed separately for each sex. Each sex showed clear patterns with the three-class model based on likelihood level of internet and smartphone addiction (P<0.001. A common trend for psychosocial trait factors was found for both sexes: anxiety levels and

  4. Attenuating effect of bioactive coumarins from Convolvulus pluricaulis on scopolamine-induced amnesia in mice.

    Science.gov (United States)

    Malik, Jai; Karan, Maninder; Vasisht, Karan

    2016-01-01

    Convolvulus pluricaulis Chois. (Convolvulaceae) has been used in Ayurveda as Medhya Rasyana (nervine tonic) to treat various mental disorders. This study was designed to isolate the bioactive compound(s) of this plant and to evaluate their effect against scopolamine-induced amnesia. Column chromatography of the chloroform and ethyl-acetate fractions led to the isolation of three coumarins identified as scopoletin, ayapanin and scopolin. All the three compounds at 2.5, 5, 10 and 15 mg/kg, p.o. were evaluated for memory-enhancing activity against scopolamine-induced amnesia using elevated plus maze and step down paradigms. Effect on acetylcholinesterase activity in mice brain was also evaluated. Scopoletin and scopolin, in both the paradigms, significantly and dose dependently attenuated the scopolamine-induced amnesic effect. Furthermore, these compounds at 10 and 15 mg/kg exhibited activity comparable to that of standard drug, donepezil. The compounds also exhibited significant acetylcholinesterase inhibitory activity.

  5. Numerical modeling of polyurea coated cementitious materials for flexure and impact loads

    Science.gov (United States)

    Pothula, Naga Deepika

    The research focuses on predicting the mechanical properties of various cementitious based materials coated with polyurea using the finite element program ABAQUS. To determine the effect of the polyurea coated systems, simple finite element analyses are performed on the beam model for flexure and the concrete slab model for impact. The experimental results carried out by Hyungjoo Choi [1, 2] are used to validate the model and to study the effect of the coating conditions of polyurea (plain, top, bottom, both). The load-displacement curves are plotted. Results show that using polyurea coating increases of deflection and load at failure (ductility), ultimate strength and strain, of Poly (Vinyl Butyral) (PVB) and Poly (Vinyl Alcohol) (PVA) fiber reinforced specimens. The simulation response for various models matched the experimental results very closely. Impact models depict the stresses developed and show that applying polyurea coating on the bottom seems to produce the best results.

  6. Small particles, big impacts: A review of the diverse applications of nanofluids

    Science.gov (United States)

    Taylor, Robert; Coulombe, Sylvain; Otanicar, Todd; Phelan, Patrick; Gunawan, Andrey; Lv, Wei; Rosengarten, Gary; Prasher, Ravi; Tyagi, Himanshu

    2013-01-01

    Nanofluids—a simple product of the emerging world of nanotechnology—are suspensions of nanoparticles (nominally 1-100 nm in size) in conventional base fluids such as water, oils, or glycols. Nanofluids have seen enormous growth in popularity since they were proposed by Choi in 1995. In the year 2011 alone, there were nearly 700 research articles where the term nanofluid was used in the title, showing rapid growth from 2006 (175) and 2001 (10). The first decade of nanofluid research was primarily focused on measuring and modeling fundamental thermophysical properties of nanofluids (thermal conductivity, density, viscosity, heat transfer coefficient). Recent research, however, explores the performance of nanofluids in a wide variety of other applications. Analyzing the available body of research to date, this article presents recent trends and future possibilities for nanofluids research and suggests which applications will see the most significant improvement from employing nanofluids.

  7. Prediction of immediately occurring microsleep events from brain electric signals

    Directory of Open Access Journals (Sweden)

    Golz Martin

    2016-09-01

    Full Text Available This contribution addresses the question if imminent changes of the cortical state are predictable. The analysis is based on 1484 examples of microsleep (MS and 1940 counterexamples of sustained attention (SA, both observed during overnight driving in the simulator. EEG segments (8 s in length immediately before each respective event were included. Features were extracted by (i modified periodogram and (ii Choi-Williams distribution. Machine learning algorithms, namely the optimized learning vector quantization (OLVQ and the support-vector machine with Gaussian kernel function (SVM, were trained in order to map signal features to the event type (MS or SA. Cross validation analysis yielded test set classification accuracies of 87.5 ± 0.1 % and 82.7 ± 0.1 % for feature set (i and (ii, respectively. In general, SVM outperformed OLVQ. In conclusion, EEG contains enough information to predict immediately upcoming microsleep events.

  8. Linear Controllers for Turbulent Boundary Layers

    Science.gov (United States)

    Lim, Junwoo; Kim, John; Kang, Sung-Moon; Speyer, Jason

    2000-11-01

    Several recent studies have shown that controllers based on a linear system theory work surprisingly well in turbulent flows, suggesting that a linear mechanism may play an important role even in turbulent flows. It has been also shown that non-normality of the linearized Navier-Stokes equations is an essential characteristic in the regeneration of near-wall turbulence structures in turbulent boundary layers. A few controllers designed to reduce the role of different linear mechanisms, including that to minimize the non-normality of the linearized Navier-Stokes equations, have been developed and applied to a low Reynolds nubmer turbulent channel flow. A reduced-order model containing the most controllable and observables modes is derived for each system. Other existing control schemes, such as Choi et al's opposition control, have been examined from the point of a linear system control. Further discussion on controller design, such as choice of cost function and other control parameters, will be presented.

  9. Dielectric properties of KDP-type ferroelectric crystals in the presence of external electric field

    Indian Academy of Sciences (India)

    Trilok Chandra Upadhyay; Ramendra Singh Bhandari; Birendra Singh Semwal

    2006-09-01

    Considering external electric field as well as third- and fourth-order phonon anharmonic interaction terms in the pseudospin-lattice coupled mode (PLCM) model Hamiltonian for KDP-type ferroelectrics, expressions for field-dependent shift, width, renormalized soft mode frequency, Curie temperature, dielectric constant and dielectric loss are evaluated. For the calculation, method of statistical double-time temperature-dependent Green's function has been used. By fitting model values of physical quantities, temperature and electric field dependences of soft mode frequency, dielectric constant and loss have been calculated which compare well with experimental results of Baumgartner [8] and Choi and Lockwood [9]. Both dielectric constant and loss decrease with electric field.

  10. The Jamio{\\l}kowski isomorphism and a conceptionally simple proof for the correspondence between vectors having Schmidt number $k$ and $k$-positive maps

    CERN Document Server

    Ranade, K S; Ali, Mazhar; Ranade, Kedar S.

    2007-01-01

    Positive maps which are not completely positive are used in quantum information theory as witnesses for convex sets of states, in particular as entanglement witnesses and more generally as witnesses for states having Schmidt number not greater than k. It is known that such witnesses are related to k-positive maps. In this article we propose a new proof for the correspondence between vectors having Schmidt number k and k-positive maps using Jamiolkowski's criterion for positivity of linear maps; to this aim, we also investigate the precise notion of the term "Jamiolkowski isomorphism". As consequences of our proof we get the Jamiolkowski criterion for complete positivity, and we find a special case of a result by Choi, namely that k-positivity implies complete positivity, if k is the dimension of the smaller one of the Hilbert spaces on which the operators act.

  11. The SLUGGS survey: revisiting the correlation between X-ray luminosity and total mass of massive early-type galaxies

    Science.gov (United States)

    Forbes, Duncan A.; Alabi, Adebusola; Romanowsky, Aaron J.; Kim, Dong-Woo; Brodie, Jean P.; Fabbiano, Giuseppina

    2017-01-01

    Here we utilize recent measures of galaxy total dynamical mass and X-ray gas luminosities (LX,Gas) for a sample of 29 massive early-type galaxies from the SLUGGS survey to probe LX, Gas-mass scaling relations. In particular, we investigate scalings with stellar mass, dynamical mass within 5 effective radii (Re) and total virial mass. We also compare these relations with predictions from Λ cold dark matter simulations. We find a strong linear relationship between LX, Gas and galaxy dynamical mass within 5Re, which is consistent with the recent cosmological simulations of Choi et al. that incorporate mechanical heating from AGN. We conclude that the gas surrounding massive early-type galaxies was shock-heated as it fell into collapsing dark matter haloes so that LX, Gas is primarily driven by the depth of a galaxy's potential well. Heating by an AGN plays an important secondary role in determining LX, Gas.

  12. Improving Entity Resolution with Global Constraints

    CERN Document Server

    Gemmell, Jim; Chandra, Ashok K

    2011-01-01

    Some of the greatest advances in web search have come from leveraging socio-economic properties of online user behavior. Past advances include PageRank, anchor text, hubs-authorities, and TF-IDF. In this paper, we investigate another socio-economic property that, to our knowledge, has not yet been exploited: sites that create lists of entities, such as IMDB and Netflix, have an incentive to avoid gratuitous duplicates. We leverage this property to resolve entities across the different web sites, and find that we can obtain substantial improvements in resolution accuracy. This improvement in accuracy also translates into robustness, which often reduces the amount of training data that must be labeled for comparing entities across many sites. Furthermore, the technique provides robustness when resolving sites that have some duplicates, even without first removing these duplicates. We present algorithms with very strong precision and recall, and show that max weight matching, while appearing to be a natural choi...

  13. On asymptotic stabilisation of a chain of integrators with nonlinearity and an uncertain input delay by output feedback

    Science.gov (United States)

    Choi, Ho-Lim

    2014-12-01

    In this paper, we provide an output feedback solution over one given by Choi and Lim [Systems & Control Letters, 59(6), 374-379 (2010)] under more generalised system set-up. More specifically, we consider a stabilisation problem of a chain of integrators that has nonlinearity and an uncertain delay in the input by output feedback. The nonlinearity is classified into four types. Then, we propose a memoryless output feedback controller which contains a gain-scaling factor to adjust controller gains depending on the given nonlinearity type. Our stability analysis shows that the controlled system has unique stabilisation result associated with each type of nonlinearity. Our result provides a new aspect to the stabilisation problem of nonlinear time-delay systems and broadens the existing control results of time-delay systems. Two examples are given for illustration.

  14. PAR Analysis of HSR Nozzles

    Science.gov (United States)

    Georgiadis, Nicholas J.

    1999-01-01

    Only recently has computational fluid dynamics (CFD) been relied upon to predict the flow details of advanced nozzle concepts. Computer hardware technology and flow solving techniques are advancing rapidly and CFD is now being used to analyze such complex flows. Validation studies are needed to assess the accuracy, reliability, and cost of such CFD analyses. At NASA Lewis, the PARC2D/3D full Navier-Stokes (FNS) codes are being applied to HSR-type nozzles. This report presents the results of two such PARC FNS analyses. The first is an analysis of the Pratt and Whitney 2D mixer-ejector nozzle, conducted by Dr. Yunho Choi (formerly of Sverdrup Technology-NASA Lewis Group). The second is an analysis of NASA-Langley's axisymmetric single flow plug nozzle, conducted by the author.

  15. Optimal control of quantum measurement

    Energy Technology Data Exchange (ETDEWEB)

    Egger, Daniel; Wilhelm, Frank [Theoretical Physics, Saarland University, 66123 Saarbruecken (Germany)

    2015-07-01

    Pulses to steer the time evolution of quantum systems can be designed with optimal control theory. In most cases it is the coherent processes that can be controlled and one optimizes the time evolution towards a target unitary process, sometimes also in the presence of non-controllable incoherent processes. Here we show how to extend the GRAPE algorithm in the case where the incoherent processes are controllable and the target time evolution is a non-unitary quantum channel. We perform a gradient search on a fidelity measure based on Choi matrices. We illustrate our algorithm by optimizing a measurement pulse for superconducting phase qubits. We show how this technique can lead to large measurement contrast close to 99%. We also show, within the validity of our model, that this algorithm can produce short 1.4 ns pulses with 98.2% contrast.

  16. Is there an educator present?

    DEFF Research Database (Denmark)

    Christiansen, René Boyer; Nortvig, Anne-Mette; Rosenlund, Lea Tilde

    2015-01-01

    In recent years, MOOCs (Massive Open Online Courses) have become a player within the field of education. MOOC research is a fairly new field but within the last 2-3 years, it has developed rapidly (Liyanagunawardena et al. 2013, Bayne & Ross 2014). Much of this research has had an emphasis...... on learners and outcome as well as suitable business models. Research has shown that online learners are normally older students (Doyle 2009, Galy et al. 2011), and because most of them have jobs and family that take up a lot of their time, they are less likely to prioritize social activities (Kahu et al....... 2013). Moreover, they see that the flexibility in online learning is vital (Park & Choi 2009), and they find it important that their former experiences are accepted and integrated in the new knowledge (Henderson, Noble & George-Walker 2009, Kahu et al. 2014, Toynton 2005). In the physical classroom...

  17. EQUIVALENCY OF FOULING THICKNESS WITH DENATURED Β-LG IN HEATING OF MILK

    Directory of Open Access Journals (Sweden)

    Heriberto Molina-Pérez

    2015-03-01

    Full Text Available This work presents an approach to match the foaling thickness of dairy food and the concentration of denatured β-lg (β-lactoglobuline by a mathematical model. This includes, on the one hand, the dynamic simulation of fouling and, on the other hand, the generation of denatured β-lg under a kinetic model. In both cases a transient energy balance is developed, including the rigorous calculation of the global coefficient, and the properties by the Choi-Okos model. The solution was obtained by a fourth order Runge-Kutta written in Excel’s Macro language Visual Basic. The equivalence concluded with a model obtained by a non-linear multiple regression that relates the concentration of denatured β-lg and the foaling thickness. This methodology is applicable to analysis equipment cleaning in which kinetic cleaning has equality by reduction of the foaling thickness.

  18. A gap theorem for the ZL-amenability constant of a finite group

    Directory of Open Access Journals (Sweden)

    Yemon Choi

    2016-12-01

    Full Text Available It was shown in [A. Azimifard, E. Samei, N. Spronk, JFA 256 (2009] that the ZL-amenability constant of a finite group is always at least~$1$, with equality if and only if the group is abelian. It was also shown in [A. Azimifard, E. Samei, N. Spronk, op cit.] that for any finite non-abelian group this invariant is at least $301/300$, but the proof relies crucially on a deep result of D. A. Rider on norms of central idempotents in group algebras.Here we show that if $G$ is finite and non-abelian then its ZL-amenability constant is at least $7/4$, which is known to be best possible. We avoid use of Rider's reslt, by analyzing the cases where $G$ is just non-abelian, using calculations from [M. Alaghmandan, Y. Choi, E. Samei, CMB 57 (2014], and establishing a new estimate for groups with trivial centre.

  19. Quantum Operations as Quantum States

    CERN Document Server

    Arrighi, P; Arrighi, Pablo; Patricot, Christophe

    2004-01-01

    In this article we formalize the correspondence between quantum states and quantum operations, and harness its consequences. This correspondence was already implicit in Choi's proof of the operator sum representation of Completely Positive-preserving linear maps; we go further and show that all of the important theorems concerning quantum operations can be derived as simple corollaries of those concerning quantum states. As we do so the discussion first provides an elegant and original review of the main features of quantum operations. Next (in the second half of the paper) we search for more results to arise from the correspondence. Thus we propose a factorizability condition and an extremal trace-preservedness condition for quantum operations, give two novel Schmidt-type decompositions of bipartite pure states and two interesting composition laws for which the set of quantum operations and quantum states remain stable. The latter enables us to define a group structure upon the set of totally entangled state...

  20. Certificates of Impossibility of Hilbert-Artin Representations of a Given Degree for Definite Polynomials and Functions

    CERN Document Server

    Guo, Feng; Zhi, Lihong

    2012-01-01

    We deploy numerical semidefinite programming and conversion to exact rational inequalities to certify that for a positive semidefinite input polynomial or rational function, any representation as a fraction of sums-of-squares of polynomials with real coefficients must contain polynomials in the denominator of degree no less than a given input lower bound. By Artin's solution to Hilbert's 17th problems, such representations always exist for some denominator degree. Our certificates of infeasibility are based on the generalization of Farkas's Lemma to semidefinite programming. The literature has many famous examples of impossibility of SOS representability including Motzkin's, Robinson's, Choi's and Lam's polynomials, and Reznick's lower degree bounds on uniform denominators, e.g., powers of the sum-of-squares of each variable. Our work on exact certificates for positive semidefiniteness allows for non-uniform denominators, which can have lower degree and are often easier to convert to exact identities. Here we...

  1. Mathematical modeling and experimental study of polarization echo in optically anisotropic media

    Science.gov (United States)

    Bogdanov, Yu. I.; Kalinkin, A. A.; Kulik, S. P.; Moreva, E. V.; Shershulin, V. A.; Belinsky, L. V.

    2013-01-01

    As optical systems are one of the candidates for implementation of a scalable quantum computer, it is important to develop an adequate method of description of both quantum states of light and operations performed by optical elements. Using the concept of chi-matrix representation of quantum operations and Choi-Jamiolkowski isomorphism we expand Jones calculus to allow description of evolution of mixed polarization states in linear optical systems. The developed method is then used to give a full description of polarization echo effect, which was described in 1 based on an analogy between the effects of polarization optics and spin dynamics. Theoretical predictions are confirmed by reconstructing operations performed by a series of quartz waveplates using quantum process tomography protocols.

  2. Optimality of Gaussian discord.

    Science.gov (United States)

    Pirandola, Stefano; Spedalieri, Gaetana; Braunstein, Samuel L; Cerf, Nicolas J; Lloyd, Seth

    2014-10-03

    In this Letter we exploit the recently solved conjecture on the bosonic minimum output entropy to show the optimality of Gaussian discord, so that the computation of quantum discord for bipartite Gaussian states can be restricted to local Gaussian measurements. We prove such optimality for a large family of Gaussian states, including all two-mode squeezed thermal states, which are the most typical Gaussian states realized in experiments. Our family also includes other types of Gaussian states and spans their entire set in a suitable limit where they become Choi matrices of Gaussian channels. As a result, we completely characterize the quantum correlations possessed by some of the most important bosonic states in quantum optics and quantum information.

  3. Note on non-Gaussianities in two-field inflation

    Science.gov (United States)

    Wang, Tower

    2010-12-01

    Two-field slow-roll inflation is the most conservative modification of a single-field model. The main motivations to study it are its entropic mode and non-Gaussianity. Several years ago, for a two-field model with additive separable potentials, Vernizzi and Wands invented an analytic method to estimate its non-Gaussianities. Later on, Choi et al. applied this method to the model with multiplicative separable potentials. In this note, we design a larger class of models whose non-Gaussianity can be estimated by the same method. Under some simplistic assumptions, roughly these models are unlikely able to generate a large non-Gaussianity. We look over some specific models of this class by scanning the full parameter space, but still no large non-Gaussianity appears in the slow-roll region. These models and scanning techniques would be useful for a future model hunt if observational evidence shows up for two-field inflation.

  4. First Principles Study of Dopant Site Selectivity in Ordered Perovskite CaCu3Ti4O12

    Institute of Scientific and Technical Information of China (English)

    XU Li-Chun; WANG Ru-Zhi; DENG Yang; YAN Hui

    2011-01-01

    We investigate the dopant site selectivity of CaCu3Ti4O12(CCTO) using the first principles calculations. Our results show that, for four cases of possible occupancy by La atom, lattice expansions and formation enthalpies with different dopant quantities indicate that doped La cations are preferentially substituted for Ca sites in CaCu3Ti4O12, which is excellent in agreement with the experimental observation(Choi et al. Adv. Mater. 21 (2009) 885).Furthermore, more interesting information of doping is also explored by the analysis of density of states and it is found that La substituting for Cu may advance the electron conduction in CCTO. It supplies a potential solution for limitations of CCTO devices by exploring the effect when La substitutes for Cu sites in the CCTO crystal.

  5. Recent progress in the use of 'omics technologies in brassicaceous vegetables

    Directory of Open Access Journals (Sweden)

    Katja eWitzel

    2015-04-01

    Full Text Available Continuing advances in 'omics methodologies and instrumentation is enhancing the under-standing of how plants cope with the dynamic nature of their growing environment. 'Omics platforms have been only recently extended to cover horticultural crop species. Many of the most widely cultivated vegetable crops belong to the genus Brassica: these include plants grown for their root (turnip, rutabaga/swede, their swollen stem base (kohlrabi, their leaves (cabbage, kale, pak choi and their inflorescence (cauliflower, broccoli.Characterization at the genome, transcript, protein and metabolite levels has illustrated the complexity of the cellular response to a whole series of environmental stresses, including nutrient deficiency, pathogen attack, heavy metal toxicity, cold acclimation, and excessive and sub-optimal irradiation. This review covers recent applications of 'omics technologies to the brassicaceous vegetables, and discusses future scenarios in achieving improvements in crop end-use quality.

  6. BOHENDI@FELIX: Probing the Far-Infrared Fingerprint of Small Clusters in Helium Nanodroplets with a Free Electron Laser

    Science.gov (United States)

    Schwaab, Gerhard; Schwan, Raffael; Mani, Devendra; Dey, Arghya; Fischer, Theo; Kaufmann, Matin; Redlich, Britta; van der Meer, Lex; Havenith, Martina

    2016-06-01

    Recently, we have installed a helium nanodroplet machine [1,2] at the free electron beamline FELIX in Nijmegen. The current setup allows to study neutral molecules and molecular complexes in the full spectral range from 500--3000 cm-1. First proof of principle experiments using the strong absorber SF_6 were used to verify the overall alignment between helium nanodroplet beam and the FELIX radiation source. Applications so far included the study of small water clusters and the investigation of microsolvation of small solutes. These results will be presented and compared to recent theoretical predictions of the Bowman group.[3] [1] K. von Haeften et al., Phys. Rev. B. 73, 054502 (2006) [2] Choi et al., Int. Rev. Phys. Chem. 25, 15 (2006) [3] Samantha et al., Acc. Chem. Res. 47, 2700 (2014)

  7. A realization of sound focused personal audio system using acoustic contrast control.

    Science.gov (United States)

    Chang, Ji-Ho; Lee, Chan-Hui; Park, Jin-Young; Kim, Yang-Hann

    2009-04-01

    A personal audio system that does not use earphone or any wire would have great interest and potential impact on the audio industries. In this study, a line array speaker system is used to localize sound in the listening zone. The contrast control [Choi, J.-W. and Kim, Y.-H. (2002). J. Acoust. Soc. Am. 111, 1695-1700] is applied, which is a method to make acoustically bright zone around the user and acoustically dark zone in other regions by maximizing the ratio of acoustic potential energy density between the bright and the dark zone. This ratio is regarded as acoustic contrast, analogous with what is used for optical devices. For the evaluation of the performance of acoustic contrast control, experiments are performed and the results are compared with those of uncontrolled case and time reversal array.

  8. Ultimate precision of adaptive quantum metrology

    CERN Document Server

    Pirandola, Stefano

    2016-01-01

    We consider the problem of estimating a classical parameter encoded in a quantum channel, assuming the most general strategy allowed by quantum mechanics. This strategy is based on the exploitation of an unlimited amount of pre-shared entanglement plus the use of adaptive probings, where the input of the channel is interactively updated during the protocol. We show that, for the wide class of teleportation-stretchable channels in finite dimension, including all Pauli channels and erasure channels, the quantum Fisher information cannot exceed an ultimate bound given by the Choi matrix of the encoding channel. We also extend our methods and results to quantum channel discrimination, finding a corresponding ultimate bound for the minimum error probability. Thus, our findings establish the ultimate precision limits that are achievable in quantum metrology and quantum discrimination for the most basic models of discrete-variable quantum channels.

  9. Characterization of Unruh Channel in the context of Open Quantum Systems

    CERN Document Server

    Banerjee, Subhashish; Omkar, S; Srikanth, R

    2016-01-01

    We show through the Choi matrix approach that the effect of Unruh acceleration on a qubit is similar to the interaction of the qubit with a vacuum bath, despite the finiteness of the Unruh temperature. Thus, rather counterintuitvely, from the perspective of decoherence in this framework, the particle experiences a vacuum bath with a temperature-modified interaction strength, rather than a thermal bath. We investigate how this "relativistic decoherence" is modified by the presence of environmentally induced decoherence, by studying the degradation of quantum information, as quantified by parameters such as nonlocality, teleportation fidelity, entanglement, coherence and quantum measurement-induced disturbance (a discord-like measure). Also studied are the performance parameters such as gate and channel fidelity. We highlight the distinction between dephasing and dissipative environmental interactions, by considering the actions of quantum non-demolition and squeezed generalized amplitude damping channels, resp...

  10. Measurement-based local quantum filters and their ability to transform quantum entanglement

    Indian Academy of Sciences (India)

    DEBMALYA DAS; RITABRATA SENGUPTA; ARVIND

    2017-06-01

    We introduce local filters as a means to detect the entanglement of bound entangled states which do not yield to detection by witnesses based on positive maps which are not completely positive.We demonstrate how suchnon-detectable bound entangled states can be locally filtered into detectable bound entangled states. Specifically, we show that a bound entangled state in the orthogonal complement of the unextendible product bases (UPB), canbe locally filtered into another bound entangled state that is detectable by the Choi map. We reinterpret these filters as local measurements on locally extended Hilbert spaces. We give explicit constructions of a measurement-basedimplementation of these filters for 2$\\otimes$2 and 3$\\otimes$3 systems. This provides us with a physical mechanism to implement such local filters.

  11. Generically large nongaussianity in small multifield inflation

    Energy Technology Data Exchange (ETDEWEB)

    Bramante, Joseph [Department of Physics, University of Notre Dame,Notre Dame, IN, 46556 (United States)

    2015-07-07

    If forthcoming measurements of cosmic photon polarization restrict the primordial tensor-to-scalar ratio to r<0.01, small field inflation will be a principal candidate for the origin of the universe. Here we show that small multifield inflation, without the hybrid mechanism, typically results in large squeezed nongaussianity. Small multifield potentials contain multiple flat field directions, often identified with the gauge invariant field directions in supersymmetric potentials. We find that unless these field directions have equal slopes, large nongaussianity arises. After identifying relevant differences between large and small two-field potentials, we demonstrate that the latter naturally fulfill the Byrnes-Choi-Hall large nongaussianity conditions. Computations of the primordial power spectrum, spectral index, and squeezed bispectrum, reveal that small two-field models which otherwise match observed primordial perturbations, produce excludably large nongaussianity if the inflatons’ field directions have unequal slopes.

  12. Use of quantitative methods in the study of cultural goods consumption in popular sectors within the city of Mexicali, B.C.

    Directory of Open Access Journals (Sweden)

    Luz María Ortega Villa

    2007-07-01

    Full Text Available In this work, a brief of the methodology used in the study of cultural goods consumption among popular sector of Mexicali is presented. It includes three phases: a survey (quantitative method, a typology established from a multivariate analysis (data mining, and interviews with selected type-cases (qualitative method all of which are analyzed from a multidimensional perspective whose categories retrieve marketing findings such as consumption visions (Phillips, Olson and Baumgartner, 1995 and conflict resolution strategies (Kwai-Choi and Collins, 2000 applied in the process of decision-making. It also draws from sociology (Thompson, 1990; Bourdieu, 1984 in order to identify reproductive aspects of consumption related to educative capital and social origin, and to deal with symbolic evaluation strategies of legitimate cultural goods.

  13. Clasificación de fallas en motores eléctricos utilizando señales de vibración

    OpenAIRE

    Arango Flórez, Gustavo Adolfo

    2007-01-01

    La tesis está encaminada a la aplicación de las técnicas tiempo frecuencia al análisis de senales de vibración para el diagnóstico de fallas en máquinas rotativas. Para esto se implementan métodos de extracción y clasificación de caracteristicas para lograr acercar de manera más precisa al diagnosticador a encontrar la causa raíz de la falla. Se realiza un estudio de cuatro métodos de extracción de características: Transformadas Wavelet, Distribución Wigner Ville, Distribución Choi Williams y...

  14. Time-frequency analysis for microwave reflectometry data processing in the HL-2A tokamak

    Science.gov (United States)

    Zhong, W. L.; Shi, Z. B.; Zou, X. L.; Ding, X. T.; Huang, X. L.; Dong, Y. B.; Liu, Z. T.; Xiao, W. W.; Ji, X. Q.; Cui, Z. Y.; Liu, Yi; Yan, L. W.; Yang, Q. W.; Duan, X. R.

    2011-10-01

    The Choi-Williams distribution (CWD) technique is introduced as a time-frequency tool for processing data measured from the new developed homodyne and the fixed frequency reflectometry in the HL-2A tokamak. The comparison between spectrogram and CWD for the simulated signal is presented. It indicates that the CWD can greatly improve the representation of the time-frequency content of the multi-components signal. Its effectiveness is demonstrated through two applications in HL-2A, which are the extraction of beat frequencies from the frequency modulated-continuous wave reflectometry (FM-CW) and the characterizing of the fluctuations. The density profile inversed from the group delay of the FM-CW and the density fluctuations deduced from the fixed-frequency reflectometry would be more reliable and accurate by using the CWD technique.

  15. Commentary: Oversight of engineered nanomaterials in the workplace.

    Science.gov (United States)

    Maynard, Andrew D

    2009-01-01

    Research and business investment in emerging nanotechnologies is leading to a diverse range of new substances and products. As workers are faced with handling new materials, often with novel properties, the robustness of current workplace health and safety regulatory frameworks is being brought into question. Here, 12 characteristics of the U.S. occupational safety regulatory framework identified by Choi and Ramachandran are considered in the context of emerging nanotechnologies. The assessment suggests that, as the number of new materials entering the workplace continues to increase, OSHA will need to develop flexible approaches to identifying and reducing potential risks. Relying on conventional approaches in the face of unconventional challenges will increase the probability of otherwise avoidable heath impacts. If the potential for engineered nanomaterials to cause harm is to be understood and managed, the agency will need to look at new approaches to generating, sharing, and using information.

  16. 基于Vague集的模糊多属性决策方法%A Multi-attribute Decision-Making Method Based on Vague Sets

    Institute of Scientific and Technical Information of China (English)

    张运良

    2010-01-01

    提出基于Vague集理论来处理模糊多属性决策问题的一些方法.对Chen 和Tan (Fuzzy sets and Systems 67(1994))163-172)、Hong和 Choi (Fuzzy sets and Systems 114(2000)103-113)等两篇论文中所提出的记分函数和精确函数进行分析验证和改进,并给出了处理模糊多属性决策问题的新方法.结果表明:新方法能够使得决策排序是严格有序的,避免了排序中不易决策的问题.

  17. Regeneration of Pharbitis nil from immature embryos by somatic embryogenesis

    Directory of Open Access Journals (Sweden)

    Alina Trejgell

    2014-01-01

    Full Text Available Immature embryos of Pharbitis nil Chois. were used for the study. They were isolated from previously sterilized fruits and afterwards transferred to Murashige and Skoog (MS growth medium with 0.8% agar. Immature embryos were cut across their axis. After 6-8 weeks of cultivation in the injury place (hypocotyl-root region somatic embryos were formed. These embryos were isolated and each of them was transferred into a separate tube containing MS supplemented with naphthaleneacetic acid (NAA; in concentration 0.1 mg•dm-3 and gibberellic acid (GA3; in concentration 0.5 mg•dm-3. Under these conditions about 26% of somatic embryos regenerated into complete plants. Two-three weeks after the photoperiodic induction flowers appeared on these plants. A few weeks after pollination normal seeds were developed from these flowers.

  18. La nécropole des Géandes à Bourg-Saint-Andéol (Ardèche) dans le cadre du dolménisme en Bas-Vivarais

    OpenAIRE

    Clottes, Jean; Duplan, Véronique; Gély, Bernard; Marguerin, Jean-François; Pape, Wolfgang; Pévérelli, Olivier

    2017-01-01

    Les dolmens ardéchois marquent la limite orientale de l'ensemble des tombes monumentales qui occupent les causses au sud et à l'ouest du Massif central à la fin du Néolithique. La plupart de ces sépultures qui sont souvent groupées en petites nécropoles assez lâches, sont dans le sud du département de l'Ardèche, concentration qui empiète sur le nord-est du Gard. Après une interruption des travaux de terrain sur les dolmens de l'Ardèche pendant plus d'une décennie et en prévision d'une opérat...

  19. Mothering from the Inside Out: A mentalization-based therapy for mothers in treatment for drug addiction.

    Science.gov (United States)

    Suchman, Nancy E

    2016-07-01

    Not all mothers with histories of substance use struggle as parents, but many of them do. Research has shown that, although quality of caregiving varies widely, as a group, mothers with histories of chronic substance use are at greater risk than mothers with no substance use history for losing custody of their young children (Grant et al., 2011; Choi & Ryan, 2006; Department of Health and Human Services, 1999). In observational studies, mothers with substance use disorders have demonstrated lower levels of sensitivity and responsiveness to their young children's emotional cues and marked oscillation between intrusive, over-controlling behavior and passive withdrawal (Hans et al., 1999; Burns et al., 1997). Recent developments in the neuroscience of addiction and parenting may help to explain the marked absence of sensitivity and the dramatic juxtaposition of parenting behaviors.

  20. Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study

    Directory of Open Access Journals (Sweden)

    Arokiyaraj S

    2014-01-01

    Full Text Available Selvaraj Arokiyaraj,1 Mariadhas Valan Arasu,2 Savariar Vincent,3 Nyayirukannaian Udaya Prakash,4 Seong Ho Choi,5 Young-Kyoon Oh,1 Ki Choon Choi,2 Kyoung Hoon Kim1,61Department of Animal Nutrition and Physiology, National Institute of Animal Science, Rural Development Administration, Suwon, Republic of Korea; 2Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Seonghwan-Eup, Cheonan-Si, Chungnam, Republic of Korea; 3Center for Environmental Research and Development, Loyola College, Chennai, India; 4Research and Development, Vel Tech Dr RR and Dr SR Technical University, Chennai, India; 5Department of Animal Science, Chungbuk National University, Chungbuk, Republic of Korea; 6Department of Animal Science, Seoul National University, Pyeongchang, Republic of KoreaAbstract: The present work reports a simple, cost-effective, and ecofriendly method for the synthesis of silver nanoparticles (AgNPs using Chrysanthemum indicum and its antibacterial and cytotoxic effects. The formation of AgNPs was confirmed by color change, and it was further characterized by ultraviolet–visible spectroscopy (435 nm. The phytochemical screening of C. indicum revealed the presence of flavonoids, terpenoids, and glycosides, suggesting that these compounds act as reducing and stabilizing agents. The crystalline nature of the synthesized particles was confirmed by X-ray diffraction, as they exhibited face-centered cubic symmetry. The size and morphology of the particles were characterized by transmission electron microscopy, which showed spherical shapes and sizes that ranged between 37.71–71.99 nm. Energy-dispersive X-ray spectroscopy documented the presence of silver. The antimicrobial effect of the synthesized AgNPs revealed a significant effect against the bacteria Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. Additionally, cytotoxic assays showed no toxicity of AgNPs toward 3T3 mouse embryo

  1. Semiactive balancing control scheme in a rotor - bearing system supported on Mr. Dampers: design and experiments

    Energy Technology Data Exchange (ETDEWEB)

    Silva Navarro, Gerardo; Cabrera Amado, Alvaro [Cinvestav, IPN, Mexico, D.F. (Mexico)

    2007-11-15

    This paper deals with the problem of semiactive balancing control of a rotor-bearing system, where one journal bearings is supported on two radial Magneto-Rheological (MR) dampers. The mathematical model of the rotor-bearing system results from an orthotropic Jeffcott-like model and the dynamics associated to the MR dampers, whose rheological properties depend on the current inputs. For control purposes we use the Choi-Lee-Park polynomial for the MR dampers, which is quite consistent with the tpical nonlinear and complex hysteresis behavior and also simplifies the physical implementation on an experimental setup. The semiactive control scheme for the unbalance reponse of the rotor-bearing system is synthesized using sliding-mode control techniques. Some numerical and experimental results are included to illustrate the dynamic performance and robustness of the overall system. [Spanish] En este trabajo se abora el problema de control semiactivo del desbalance en un sistema rotor-chumacera, donde una de las chumaceras convencionales se monta sobre una suspension con dos amortiguadores Magneto-Reologicos (MR) radiales. El modelo matematico del sistema rotorchumacera se obtiene de un modelo tipo Jefcott ortotropico y la dinamica de los amortiguadores MR, cuyas propiedades reologicas dependen de las corrientes electricas de alimentacion. Para propositos de control se emplea el modelo polinomial de Choi-Lee-Park para los dos amortiguadores MR, el cual es consistente con el tipico comportamiento no-lineal y de histeresis, permitiendo simplificar su implementacion fisica en una plataforma experimental. El esquema de control semiactivo de la respuesta al desbalance, en el sistema rotor-chumacera, se basa en las tecnicas de control por modos deslizantes. Se presentan algunos resultados de simulacion numerica y experimentos que utilizan el funcionamiento y robustez del sistema completo.

  2. Functional analysis of three amino acid residues of purR re-pressor, Trp147, Gln-218 and Gln-292 in Salmonella typhi-murium

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Hesheng

    2001-01-01

    [1]Zalkin, H., Nygaard, P., Escherichia coli and Salmmella typhimurium Cellular and Molecular Biology, Washington D.C: American Society for Microbiology, 1996, 561-579.[2]Maria, A. S., Choi, K. Y., Lu, F. et al., Mechanism of co-repressor mediated specific DNA binding by the purine repressor, Cell, 1995, 83: 147.[3]Choi, K. Y., Fu, L., Zalkin, H., Mutagenesis of amino acid residues required for binding of co-repressors to the purine repressor, J. Biol. Chem., 1993, 269: 24066.[4]Lu, F., Brennan, R. G., Zalkin, H., Escherichia coli purine repressor: key residues for the allsteic transition between active and inactive conformation and for inter domain signaling, Biochemistry, 1998, 37: 15680.[5]Tang Hua, Qin Junchuan, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (VI)-- Isolation and characterization of superrepressor mutants, Chinese Journal of Genetics (in Chinese), 1998, 25(2): 181.[6]Zhang Hesheng, Wang Aoquan, Regulation of purine biosynthetic genes expression in Salmonella typhimurium (X)--Isola-tion of purR(am) mutant and preliminary study of amino acid substitution, Chinese Journal of Genetics (in Chinese), 2000, 27(2): 170.[7]Davis, R. W., Roth, J. R., Advanced Bacteria Genetics, NY: Cold Spring Harbor Laboratory Press, 1984.[8]Miller, J. H., Experiments in Molecular Genetics, NY: Cold Spring Harbor Laboratory Press, 1972.[9]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, NY: Cold Spring Harbor laboratory Press, 1989.[10] Katzif, S. D., Lu, C. D., Abdelal, A.T., Salmonela typhimurium purine nucleotide synthesis repressor (purR), GenBank, Ac-cession AF040636, 1998.[11] Weicket,M.J.,Adhya,S., A family of bacteria regulators homologous to Gal and Lac repressors,J.Biol.Chem.,1992,267:15869.

  3. James C. McGroddy Prize for New Materials Talk: What is new in multiferroicity?: Mott ferroelectrics!

    Science.gov (United States)

    Cheong, Sang-Wook

    2010-03-01

    Multiferroicity is an old topic. For example, linear magnetoelectric effect in materials such as Cr2O3 with broken time reversal and space inversion symmetry has been known since 1960's. However, giant cross-coupling effects such as flipping polarization or enormous change of dielectric constant by applied magnetic fields have been recently observed in systems such as Tb(Dy)MnO3 and Tb(Dy)Mn2O5 [1-3]. The important ingredient for these giant magnetoelectric effects turns out to be associated with the presence of non-zero d electrons and their mutual interactions, leading to the Mott-insulator-type charge gap, magnetism, and collective phase transitions. Particularly, the collective nature of simultaneous magnetic-ferroelectric phase transitions results in the giant magnetoelectric effects. In addition, fascinating charge transport properties such as a switchable photovoltaic effect and characteristic conduction properties at domain walls stem from the (carrier-doped) Mott insulating nature of compounds such as BiFeO3 and hexagonal YMnO3 [4,5]. [4pt] [1] Kimura, T. et al. Magnetic control of ferroelectric polarization. Nature 426, 55--58 (2003).[0pt] [2] Hur, N. et al. Electric polarization reversal and memory in a multiferroic material induced by magnetic fields. Nature 429, 392--395 (2004).[0pt] [3] Cheong, S.-W. & Mostovoy, M. Multiferroics: a magnetic twist for ferroelectricity. Nature Mater. 6, 13--20 (2007).[0pt] [4] Seidel, J. et al. Conduction at domain walls in oxide multiferroics. Nature Mater. 8, 229--234 (2009).[0pt] [5] Choi, T., Lee, S., Choi, Y.J., Kiryukhin, V. & Cheong, S.-W. Switchable ferroelectric diode and photovoltaic effect in BiFeO3. Science 324, 63--66 (2009)

  4. CAN THE MASSES OF ISOLATED PLANETARY-MASS GRAVITATIONAL LENSES BE MEASURED BY TERRESTRIAL PARALLAX?

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, M.; Botzler, C. S.; Bray, J. C.; Cherrie, J. M.; Rattenbury, N. J. [Department of Physics, University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Philpott, L. C. [Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z4 (Canada); Abe, F.; Muraki, Y. [Solar-Terrestrial Environment Laboratory, Nagoya University, Nagoya 464-8601 (Japan); Albrow, M. D. [Department of Physics and Astronomy, University of Canterbury, P.O. Box 4800, Christchurch 8020 (New Zealand); Bennett, D. P. [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Bond, I. A. [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand); Christie, G. W.; Natusch, T. [Auckland Observatory, PO Box 180, Royal Oak, Auckland 1345 (New Zealand); Dionnet, Z. [Université d' Orsay, bat 470, F-91400 Orsay (France); Gould, A. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Han, C. [Department of Physics, Chungbuk National University, 410 Seongbong-Rho, Hungduk-Gu, Chongju 371-763 (Korea, Republic of); Heyrovský, D. [Institute of Theoretical Physics, Charles University in Prague, Faculty of Mathematics and Physics, V Holesovickach 2, 18000 Prague (Czech Republic); McCormick, J. M. [Farm Cove Observatory, 2/24 Rapallo Place, Pakuranga, Auckland 2012 (New Zealand); Moorhouse, D. M. [Kumeu Observatory, Kumeu (New Zealand); Skowron, J., E-mail: mfre070@aucklanduni.ac.nz [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478, Warszawa (Poland); and others

    2015-02-01

    Recently Sumi et al. reported evidence for a large population of planetary-mass objects (PMOs) that are either unbound or orbit host stars in orbits ≥10 AU. Their result was deduced from the statistical distribution of durations of gravitational microlensing events observed by the MOA collaboration during 2006 and 2007. Here we study the feasibility of measuring the mass of an individual PMO through microlensing by examining a particular event, MOA-2011-BLG-274. This event was unusual as the duration was short, the magnification high, the source-size effect large, and the angular Einstein radius small. Also, it was intensively monitored from widely separated locations under clear skies at low air masses. Choi et al. concluded that the lens of the event may have been a PMO but they did not attempt a measurement of its mass. We report here a re-analysis of the event using re-reduced data. We confirm the results of Choi et al. and attempt a measurement of the mass and distance of the lens using the terrestrial parallax effect. Evidence for terrestrial parallax is found at a 3σ level of confidence. The best fit to the data yields the mass and distance of the lens as 0.80 ± 0.30 M {sub J} and 0.80 ± 0.25 kpc respectively. We exclude a host star to the lens out to a separation ∼40 AU. Drawing on our analysis of MOA-2011-BLG-274 we propose observational strategies for future microlensing surveys to yield sharper results on PMOs including those down to super-Earth mass.

  5. Organic soil production from urban soil, spent mushroom substrate, and other additives

    Science.gov (United States)

    Pham, Nhung Thi Ha

    2017-09-01

    In recent years, spent mushroom substrate (SMS) is becoming the huge problem in environmental pollution issues from mushroom production. However, SMS is also a nutrient-rich ogranic material with available nutrients and high porosity. Therefore, the value of products made from SMS should be exploited to take full advantage of agricultural by-product, support organic agriculture development without environmental pollution. The research has built 5 experimental formulas (4 mixed formulas and 1 control formulas with only urban soil). The analysis results of soil samples from mixed formulas and the control formula witness a significant increase in moisture and OM of mixed formulas (moisture from 36-42%, OM from 5.5-6.9%) after 20 treatment days, and N-P-K contents are also improved remarkably. 60 days later, soil nutrients in mixed formulas continue to rise, with highest OM (8.679%) at CT1; N (0.154%) at CT4; K2O (0,698%) and P2O5 (0,172%) at CT3, in addition, heavy metal contents in all formulas are under standard limit. Synthetic assessment of all norms indicates that the best organic soil product comes from CT3. The pak choi planting experiments are performed show that the growth of plants cultivated on organic soil products made from mixed formulas are much better than plants are grown on initially soil, and they also have no pestilent insect. Specially, pak choi planted on organic soil from CT3 have sharp developing with excellent tolerance ability, quantity and area of leaves are high. Thus, CT3 is the most suitable formula to increase soil nutrients, to solve spent mushroom subtrate streament problems after harvest, and for sustainable agricultural development.

  6. EMD与CWD结合在暂态电能质量扰动检测中的应用%Application of united EMD and CWD to detection of disturbance to transient power quality

    Institute of Scientific and Technical Information of China (English)

    郭晓婷; 刘伟; 李建

    2012-01-01

    In order to suppress the cross term interference in the Cohen-class quadratic time-frequency distribution, a method was proposed based on empirical mode decomposition (EMD) and Choi-Williams distribution. In this method, several intrinsic mode functions (IMFs) of the signals were separated from the frequency domain by using EMD. The time-frequency transformation of Cohen-class distribution was carried out after deleting the false components generated by EMD, and then the Cohen-class time-frequency distribution of original signal was reconstructed by means of linear superposition of the IMFs Cohen-class distribution results. Simulation results showed that the method could be used to suppress effectively the cross terms of Cohen-class distribution, ensure Cohen-class distribution time-frequency concentration, and extract disturbance features.%针对Cohen类二次型时频分布存在的交叉项,提出一种基于EMD与Choi-Williams分布相结合的方法,利用经验模态分解将信号从频域上分离若干个固有模态函数经过去伪后进行Cohen分布的时频变换,将得到的结果叠加重构出原始信号的Cohen类时频分布.仿真结果表明,该方法能有效抑制时频分布的交叉项,保证Cohen分布的时频聚集性,提取扰动特征.

  7. The contribution of HGAL/GCET2 in immunohistological algorithms: a comparative study in 424 cases of nodal diffuse large B-cell lymphoma.

    Science.gov (United States)

    Gualco, Gabriela; Bacchi, Lívia M; Domeny-Duarte, Pollyanna; Natkunam, Yasodha; Bacchi, Carlos E

    2012-11-01

    Diffuse large B-cell lymphoma can be subclassified into at least two molecular subgroups by gene expression profiling: germinal center B-cell like and activated B-cell like diffuse large B-cell lymphoma. Several immunohistological algorithms have been proposed as surrogates to gene expression profiling at the level of protein expression, but their reliability has been an issue of controversy. Furthermore, the proportion of misclassified cases of germinal center B-cell subgroup by immunohistochemistry, in all reported algorithms, is higher compared with germinal center B-cell cases defined by gene expression profiling. We analyzed 424 cases of nodal diffuse large B-cell lymphoma with the panel of markers included in the three previously described algorithms: Hans, Choi, and Tally. To test whether the sensitivity of detecting germinal center B-cell cases could be improved, the germinal center B-cell marker HGAL/GCET2 was also added to all three algorithms. Our results show that the inclusion of HGAL/GCET2 significantly increased the detection of germinal center B-cell cases in all three algorithms (P<0.001). The proportions of germinal center B-cell cases in the original algorithms were 27%, 34%, and 19% for Hans, Choi, and Tally, respectively. In the modified algorithms, with the inclusion of HGAL/GCET2, the frequencies of germinal center B-cell cases were increased to 38%, 48%, and 35%, respectively. Therefore, HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma. Consideration should be given to the inclusion of HGAL/GCET2 analysis in algorithms to better predict the cell of origin. These findings bear further validation, from comparison to gene expression profiles and from clinical/therapeutic data.

  8. The influence of bile salt on the chemotherapeutic response of docetaxel-loaded thermosensitive nanomicelles

    Directory of Open Access Journals (Sweden)

    Kim DW

    2014-08-01

    Full Text Available Dong Wuk Kim,1,* Thiruganesh Ramasamy,2,* Ju Yeon Choi,2 Jeong Hwan Kim,2 Chul Soon Yong,2 Jong Oh Kim,2 Han-Gon Choi1 1College of Pharmacy, Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, South Korea; 2College of Pharmacy, Yeungnam University, Gyongsan, South Korea *These two authors contributed equally to this work Abstract: The primary aim of this work was to investigate the potential of bile salt, sodium taurocholate (NaTC, in improving the bioavailability and anti-tumor efficacy of docetaxel (DCT upon rectal administration. Poloxamer-based nanomicelles with thermosensitive and mucoadhesive properties were prepared using the cold method. The optimized nanomicellar formulation was evaluated in terms of physicochemical and viscoelastic parameters. Nanomicelles containing bile salt maintained sufficient gelation strength (234×102 mPa·s and mucoadhesive force (17.3×102 dyne/cm2 to be retained in the upper part of the rectum. They significantly enhanced the DCT internalization across the rectal mucosa and showed a high plasma level during the first 4 hours of the study period, compared to nanomicelles with no bile salt. As a result, a slightly higher rectal bioavailability of ~33% was observed in nanomicelles containing bile salt, compared to ~28% from the latter system. The higher pharmacokinetic parameters for rectally administered DCT/P407/P188/Tween 80/NaTC (0.25%/11%/15%/10%/0.1% by weight, respectively resulted in significant anti-tumor efficacy. However, the tumor regression rate for the NaTC group was not statistically different from that for nanomicelles without NaTC. Therefore, overall results suggest that thermosensitive nanomicelles could be a potential dosage form for improvement of the bioavailability and chemotherapeutic profile of DCT. Keywords: anti-cancer efficiency, bioavailability, docetaxel, liquid suppository, rectal delivery, thermosensitive

  9. Multi-color phase imaging and sickle cell anemia (Conference Presentation)

    Science.gov (United States)

    Hosseini, Poorya; Zhou, Renjie; Yaqoob, Zahid; So, Peter T. C.

    2016-03-01

    Quantitative phase measurements at multiple wavelengths has created an opportunity for exploring new avenues in phase microscopy such as enhancing imaging-depth (1), measuring hemoglobin concentrations in erythrocytes (2), and more recently in tomographic mapping of the refractive index of live cells (3). To this end, quantitative phase imaging has been demonstrated both at few selected spectral points as well as with high spectral resolution (4,5). However, most of these developed techniques compromise imaging speed, field of view, or the spectral resolution to perform interferometric measurements at multiple colors. In the specific application of quantitative phase in studying blood diseases and red blood cells, current techniques lack the required sensitivity to quantify biological properties of interest at individual cell level. Recently, we have set out to develop a stable quantitative interferometric microscope allowing for measurements of such properties for red cells without compromising field of view or speed of the measurements. The feasibility of the approach will be initially demonstrated in measuring dispersion curves of known solutions, followed by measuring biological properties of red cells in sickle cell anemia. References: 1. Mann CJ, Bingham PR, Paquit VC, Tobin KW. Quantitative phase imaging by three-wavelength digital holography. Opt Express. 2008;16(13):9753-64. 2. Park Y, Yamauchi T, Choi W, Dasari R, Feld MS. Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells. Opt Lett. 2009;34(23):3668-70. 3. Hosseini P, Sung Y, Choi Y, Lue N, Yaqoob Z, So P. Scanning color optical tomography (SCOT). Opt Express. 2015;23(15):19752-62. 4. Jung J-H, Jang J, Park Y. Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging. Anal Chem. 2013;85(21):10519-25. 5. Rinehart M, Zhu Y, Wax A. Quantitative phase spectroscopy. Biomed Opt Express. 2012;3(5):958-65.

  10. Rooting the tree of life by transition analyses

    Directory of Open Access Journals (Sweden)

    Cavalier-Smith Thomas

    2006-07-01

    outside Posibacteria (Actinobacteria and Endobacteria, and thus among negibacteria with two membranes. Posibacteria are derived from Eurybacteria and ancestral to neomura. RNA polymerase and other insertions strongly favour the monophyly of Gracilicutes (Proteobacteria, Planctobacteria, Sphingobacteria, Spirochaetes. Evolution of the negibacterial outer membrane places the root within Eobacteria (Hadobacteria and Chlorobacteria, both primitively without lipopolysaccharide: as all phyla possessing the outer membrane β-barrel protein Omp85 are highly probably derived, the root lies between them and Chlorobacteria, the only negibacteria without Omp85, or possibly within Chlorobacteria. Conclusion Chlorobacteria are probably the oldest and Archaebacteria the youngest bacteria, with Posibacteria of intermediate age, requiring radical reassessment of dominant views of bacterial evolution. The last ancestor of all life was a eubacterium with acyl-ester membrane lipids, large genome, murein peptidoglycan walls, and fully developed eubacterial molecular biology and cell division. It was a non-flagellate negibacterium with two membranes, probably a photosynthetic green non-sulphur bacterium with relatively primitive secretory machinery, not a heterotrophic posibacterium with one membrane. Reviewers This article was reviewed by John Logsdon, Purificación López-García and Eric Bapteste (nominated by Simonetta Gribaldo.

  11. The mediating role of cytokine IL-6 on the relationship of FEV1 upon 6-minute walk distance in chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Baldi S

    2014-10-01

    Full Text Available Simonetta Baldi,1 Paul E Jose,2 Claudio Bruschi,1 Gian Domenico Pinna,3 Roberto Maestri,3 Antonella Rezzani,1 Ezio Bellinzona,1 Claudio Fracchia,1 Elena Dacosto,1 Paola Crotti,1 Silvia Montemartini1 1Department of Pneumology, Scientific Institute of Montescano, Salvatore Maugeri Foundation IRCCS, Montescano, Pavia, Italy; 2School of Psychology, Victoria University, Wellington, New Zealand; 3Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation IRCCS, Montescano, Pavia, ItalyObjectives: To explore the mediating role of protein interleukin-6 (IL-6 on the relationship between forced expiratory volume in 1 second (FEV1 and 6-minute walk distance (6MWD and, further, to determine whether status variables (such as age, sex, and body mass index [BMI] operate as moderators of this mediation relationship.Design: Moderated mediation model.Setting: An inpatient pulmonary rehabilitation center in Italy.Participants: All 153 patients involved in the screening of a randomized controlled clinical trial (ClinicalTrials.gov identifier: NCT01253941 were included in this study. All patients were Global initiative for chronic Obstructive Lung Disease (GOLD stages I–IV and were aged 70.1±9.1 years.Measurements: At run-in phase of the protocol, clinical and functional screening included BMI, fasting plasma levels of protein (IL-6, spirometry, and standardized 6-minute walking test, measured at the start of the respiratory rehabilitation program.Methods: The size of the indirect effect of the initial variable (FEV1 upon the outcome variable (6MWD through the intervening variable (IL-6 was computed and tested for statistical significance. Moderated mediation analyses were subsequently conducted with age, sex, and BMI.Results: FEV1 averaged 53.4%±21.2%, and 6MWD 66.4%±41.3% of predicted. Median protein IL-6 was 6.68 pg/mL (interquartile range: 5.96. A bootstrapped mediation test supported the predicted indirect

  12. BOOK REVIEW Analytical and Numerical Approaches to Mathematical Relativity

    Science.gov (United States)

    Stewart, John M.

    2007-08-01

    . This reviewer found the exposition much clearer than much of the phenomenological literature. Finally László Szabados gives a very systematic spacetime discussion of the group theoretical analysis of general relativity by Beig and Ó Murchadha, addressing the Poincaré structure and the centre-of-mass of asymptotically flat spacetimes. The third and final group is entitled 'numerical methods'. Beverly Berger summarizes her 'Living Review' on numerical approaches to spacetime singularities and includes more recent analytical results emphasizing the synergy between mathematical and numerical approaches. For numerical evolutions on a domain of compact spatial support boundary conditions will be needed and, as pointed out by this reviewer, for unconstrained evolutions it is essential that the boundary conditions ensure constraint conservation. This aspect is discussed in a clear elementary way by Simonetta Frittelli and Roberto Gómez. Dave Neilsen, Luis Lehner, Olivier Sarbach and Manuel Tiglio review algorithms adopted recently by the Louisiana group, particularly summation by parts and constraint monitoring with applications to bubble and black hole spacetimes. Finally Maria Babiuc, Béla Szilágyi and Jeffrey Winicour discuss the Pittsburgh group's approach with particular reference to harmonic gauge conditions. It is perhaps unfortunate for the editors of this work that published proceedings of more recent numerical relativity meetings exist already. However, as this reviewer has tried to indicate, this slim (but not inexpensive) volume contains a wealth of diverse, fascinating material which needs to be perused by research students and others new to this field. Many will wish to buy it, but even if you do not, make sure your institution's library purchases a copy!

  13. Co-authorship patterns and networks of Korean radiation oncologists.

    Science.gov (United States)

    Choi, Jinhyun; Kang, Jin Oh; Park, Seo Hyun; Kim, Sang Ki

    2011-09-01

    . Among the analysis, a significant difference in the average number of author per article was indicated. The out-degree centrality of network among authors was 4.26% (2.03.7.09%) while in-degree centrality was 1.31% (0.53.2.84%). The three significant nodes were classified and listed as following: Choi, Eun Kyung for 1991-1995, Kim, Dae Young for 1998-2001, Park, Won and Lee, Sang Wook for 2003-2010. Choi, Eun Kyung and Kim, Dae Young appeared in two cases, and ranked as the highest degree in centrality. In the key player analysis, Choi, Eun Kyung and Lee, Sang Wook appeared in two cases, and ranked as the highest. From the cluster analysis, Sungkyunkwan University, Seoul National University and Yonsei University revealed as the three large clusters when Ulsan University, Chonnam National University, and Korea Institute of Radiological & Medical Science as the medium clusters. The Korean radiation oncologist's society shows a closed network with numerous relationships among the particular clusters, and the result indicates it is different from other institutions in the pattern of co-authorship formation of the major hospitals.

  14. 雄性不育相关基因msLTP的反义RNA验证%Validation of a msLTP Gene Related to Male Sterility by Antisense RNA

    Institute of Scientific and Technical Information of China (English)

    田爱梅

    2012-01-01

    Based on the cDNA sequence of msLTP related to male sterility of Chinese cabbage-pak-choi (Brassica campestris ssp. chinensis var. communis,syn. B. rapa ssp. chinensis var. communis) , a pair of specific primers were designed and a 312 bp fragment was amplified from the cDNA of flower buds of Chinese cabbage-pak-choi. The fragment was introduced to binary vector pBI121,and the generated antisene RNA vector was then mobilized into Agrobacterium lumefaciens strain LBA4404. The A. tumefaciens harboring the msLTP fragment was transformed to flowering Chinese cabbage (B. campestris ssp. chinensis var. parachinensis) via tissue culture and Agrobacterium-mediated transformation. The transgenic plants were confirmed by PCR and Southern blot, and 25 independent transgenic plants were obtained. The pollen grains from transgenic plants exhibited abnormal shapes, and only 38. 56% of pollen grains from these plants germinated normally. The germination rate was reduced 37. 76 percentage points than that of pollen grains from nontransgenic plants (78. 32%). These results indicated that msLTP gene interrupted by anti-sense RNA resulted in partial pollen grains abortion in flowering Chinese cabbage,suggesting that msLTP gene possesses an important role in pollen development of Chinese cabbage crops such as Chinese cabbage-pak-choi and flowering Chinese cabbage.%根据普通白菜雄性不育相关的脂质转移蛋白基因(msLTP)的cDNA序列设计引物,从普通白菜花蕾的cDNA中扩增出312bp的片段,然后将该片段连接至双元载体pBI121中,得到反义RNA植物表达载体并导入农杆菌LBA4404菌株中,通过农杆菌介导法转化菜心;利用PCR和Southern blot分析检测得到了25株转基因植株,转基因植株的花粉部分畸形或空瘪,花粉离体萌发率为38.56%,较末转化植株的萌发率(76.32%)降低了37.76个百分点.研究表明,反义RNA技术使msLTP基因沉默而导致了菜心转基因植株的部分花粉发育不良,

  15. Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

    Directory of Open Access Journals (Sweden)

    Kim SR

    2016-11-01

    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Sang Hyun Kim,1 Ha Ra Cho,2 Han Sol Kim,2 Yong Seok Choi,2 Young Wook Choi,1 Myung Joo Kang2 1Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea Abstract: Piroxicam (PRX, a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA in the synovial cavity. PRX-loaded NPs consisting of poly(lactic-co-glycolic acid, Eudragit RL, and polyvinyl alcohol were constructed with the following characteristics: particle size of 220 nm, zeta potential of 11.5 mV in phosphate-buffered saline, and loading amount of 4.0% (w/w of PRX. In optical and hyperspectral observations, the cationic NPs formed more than 50 µm-sized aggregates with HA, which was larger than the intercellular gaps between synoviocytes. In an in vivo pharmacokinetic study in rats, area under the plasma concentration–time curve (AUC0–24 h and maximum plasma concentration (Cmax of PRX after IA injection of the cationic NPs were <70% (P<0.05 and 60% (P<0.05, respectively, compared to those obtained from drug solution. Moreover, the drug concentration in joint tissue 24 h after dosing with the cationic NPs was 3.2-fold (P<0.05 and 1.8-fold (P<0.05 higher than that from drug solution and neutrally charged NPs, respectively. Therefore, we recommend the IA cationic NP therapy as an effective alternative to traditional oral therapy with PRX, as it increases drug retention selectively in the joint. Keywords: piroxicam

  16. Carbon monoxide in the distantly active centaur 174P/Echeclus

    Science.gov (United States)

    Wierzchos, Kacper; Womack, Maria

    2016-10-01

    60558 Echeclus is very unusual. It has a dual asteroid-comet designation, and is classified as a centaur. A dust-rich outburst was observed when it was at a heliocentric distance, r, of 13.1 AU pre-perihelion (Choi & Weissman 2006). Interestingly, the coma's center of brightness was not at the nucleus location, but was offset by up to 7 arcseconds (Weissman et al. 2006, Tegler et al. 2006). This was hypothesized to be a due to a fragment that split off the nucleus and began outgassing on its own (Fernandez 2009). A smaller coma was observed when Echeclus was at r = 8.5 AU, but overall, the object appears dormant with little or no extended coma observed at optical wavelengths for years at a time (Choi et al. 2015, Rousselot et al. 2015). Echeclus is too far from the Sun for any of the activity to be caused by water-ice sublimation, the dominant cause for most comets. Instead, the coma must have been generated by another mechanism, such as impact or supervolatile outgassing. If a substantial amount of the supervolatile CO were relatively near the surface and outgassing, then its emission could be detected, or significant limits could be set, through radio observations when Echeclus was near perihelion, which occurred at 2015 Apr at r = 5.8 AU. In order to better explore the volatile nature of this centaur, we searched for CO emission from the J=2-1 rotational line at 230 GHz with the Arizona Radio Observatory (ARO) 10-m Sub-millimeter Telescope (SMT) during May and June 2016 when the comet was at r = 6.1 AU, post-perihelion. We find that the CO production rate from Echeclus is substantially lower than what is typically observed for 29P/Schwassmann Wachmann 1, another distantly active comet often classified as a centaur. We report on the measurements and implications.The SMT is operated by the ARO, the Steward Observatory, and the University of Arizona, with support through the NSF University Radio Observatories program (AST-1140030).

  17. Strong Internal Wave Solitons in a 2.5 Layer Model

    Science.gov (United States)

    Voronovich, A.

    2003-04-01

    "Strong" internal wave (IW) solitons, i.e. IW solitary waves with amplitudes comparable to the characteristic vertical scale of stratification are often observed in field experiments. Theoretical description of such solitons is usually based on a 2-layer model, which approximates stratification by two layers of homogeneous fluid with different densities (another possibility is to assume nearly-exponential density profile). Appropriate solitons are investigated in detail by Choi and Camassa (J. Fluid Mech., v. 396, pp. 1-36, 1999). In geophysical applications, however, stratification can be better represented by layers with constant Brunt-Vaisala frequency profiles. The model consisting of two such layers with a density jump between the layers is referred here as a "2.5 layer model". Motion in this case is not potential, however similarly to homogeneous layers, equation of motion in such system in stationary case and in the Boussinesq approximation is also linear, and non-linearity appears due to dynamic boundary condition between layers only. This allows one in the case of long waves to obtain an explicit equation for IW soliton profile. This equation can be reduced to the equation describing zero-energy particle in a potential well. In the case of homogeneous layers with zero density gradients they reduce to the solitons investigated by Choi and Camassa, and in the limit of small amplitudes they reduce to the appropriate KdV solitons. This solution was applied to the case of solitons measured in the COPE experiment. Soliton profiles calculated are in a good agreement with measurements, and the relation between soliton width and amplitude is also in a fair agreement with the data, especially for large-amplitude solitons. In contrast to the two-layer model solitons in the 2.5 layer model could belong to higher modes. Another interesting feature is a presence in a sufficiently strong soliton of a recirculation core, i.e. a portion of fluid which is entrained within

  18. Optimized wavelets for blind separation of nonstationary surface myoelectric signals.

    Science.gov (United States)

    Farina, Dario; Lucas, Marie-Françoise; Doncarli, Christian

    2008-01-01

    Surface electromyography (EMG) signals detected over the skin surface may be mixtures of signals generated by many active muscles due to poor spatial selectivity of the recording. In this paper, we propose a new method for blind source separation (BSS) of nonstationary signals modeled as linear instantaneous mixtures. The method is based on whitening of the observations and rotation of the whitened observations. The rotation is performed by joint diagonalization of a set of spatial wavelet distributions (SWDs). The SWDs depend on the selection of the mother wavelet which can be defined by unconstrained parameters via the lattice parameterization within the multiresolution analysis framework. As the sources are classically supposed to be mutually uncorrelated, the design parameters of the mother wavelet can be blindly optimized by minimizing the average (over time lags) cross correlation between the estimated sources. The method was tested on simulated and experimental surface EMG signals and results were compared with those obtained with spatial time-frequency distributions and with second-order statistics (only spectral information). On a set of simulated signals, for 10-dB signal-to-noise ratio (SNR), the cross-correlation coefficient between original and estimated sources was 0.92 +/- 0.07 with wavelet optimization, 0.74 +/- 0.09 with the wavelet leading to the poorest performance, 0.85 +/- 0.07 with Wigner-Ville distribution, 0.86 +/- 0.07 with Choi-Williams distribution, and 0.73 +/- 0.05 with second-order statistics. In experimental conditions, when the flexor carpi radialis and pronator teres were concomitantly active for 50% of the time, crosstalk was 55.2 +/- 10.0% before BSS and was reduced to 15.2 +/- 6.3% with wavelet optimization, 30.1 +/- 15.0% with the worst wavelet, 28.3 +/- 12.3% with Wigner-Ville distribution, 26.2 +/- 12.0% with Choi-Williams distribution, and 35.1 +/- 15.5% with second-order statistics. In conclusion, the proposed approach

  19. Assessment of the Level of Satisfaction and Unmet Data Needs for Specialty Drug Formulary Decisions in the United States.

    Science.gov (United States)

    Choi, Yoonyoung; Navarro, Robert P

    2016-04-01

    internal economic analyses as having the strongest evidence strength. The study respondents believed that pharmaceutical manufacturers would be best able to satisfy the greatest clinical data unmet need, that is, head-to-head RCTs in specialty drug formulary decisions. This study was not funded by any company or pharmaceutical manufacturer. Navarro has worked as a consultant for Biogen, Purdue Pharma, and Novartis and has offered expert testimony on behalf of AstraZeneca. The authors declare no other potential conflicts of interest. Study design was contributed primarily by Navarro, along with Choi. Choi took the lead in data collection and interpretation, assisted by Navarro. Both authors contributed equally to manuscript writing and revision.

  20. Tat peptide-admixed elastic liposomal formulation of hirsutenone for the treatment of atopic dermatitis in Nc/Nga mice

    Directory of Open Access Journals (Sweden)

    Kang MJ

    2011-10-01

    Full Text Available Myung Joo Kang1, Jae Yoon Eum1, Mi Sook Jeong2, Sang Han Park1, Ki Young Moon1, Mean Hyung Kang1, Min Soo Kim1, Sun Eun Choi1, Min Won Lee1, Do Ik Lee1, Hyoweon Bang2, Chung Soo Lee2, Seong Soo Joo3, Kapsok Li2, Mi-Kyung Lee2, Seong Jun Seo2, Young Wook Choi11College of Pharmacy, ChungAng University, Heuksuk-dong, Dongjak-gu, Seoul, 2College of Medicine, Chung-Ang University, Heuksukdong, Dongjak-gu, Seoul, 3Division of Marine Molecular Biotechnology, Gangneung-Wonju National University, Gangneung, South KoreaBackground: The aim of the present study was to enhance a topical delivery of hirsutenone (HST, a naturally occuring immunomodulator, employing Tat peptide-admixed elastic liposomes (EL/T.Methods: HST-loaded EL, consisting of phosphatidylcholine and Tween 80 (85:15 w/w%, were prepared using thin film hydration method. By adding Tat peptide to EL (0.16 w/w%, EL/T were formulated. The in vitro skin permeation of HST was examined using a Franz diffusion cell mounted with depilated mouse skin. Lesions for atopic dermatitis (AD were induced by a topical application of diphenylcyclopropenone to NC/Nga mice. Therapeutic improvements of AD were evaluated by clinical skin severity scores. Immunological analyses on inducible nitric oxide synthase and cyclooxygenase-2 levels in the skin and interleukin (IL-4, IL-13, immunoglobulin E, and eosinophil levels in the blood were also performed.Results: EL systems were superior to conventional cream, revealing greater flux values in a permeation study. The addition of Tat peptide further increased the skin permeation of HST. In an efficacy study with AD-induced NC/Nga mice, an HST-containing EL/T formulation brought a significant improvement in both skin severity score and immune-related responses for the levels of nitric oxide synthase, cyclooxygenase-2, IL-4, IL-13, immunoglobulin E, and eosinophils.Conclusion: A novel EL/T formulation was successfully developed for topical delivery of HST to treat AD

  1. Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers

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    Kim YH

    2015-03-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Hyeong-Seok Lim,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Donghyun Hong,2 Seong Su Kim,2 Young Kweon Choi,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea; 2iCure Pharmaceutical lncorporated, Anseong, Gyeonggi-do, Republic of Korea Background: Donepezil is an acetylcholinesterase inhibitor indicated for Alzheimer’s disease. The aim of this randomized, single-blind, placebo-controlled, single-dose, dose-escalation study was to investigate the safety, tolerability, and pharmacokinetics of the donepezil patch in healthy male subjects. Methods: Each healthy male subject received a single transdermal donepezil patch (72 hours patch-on periods of 43.75 mg/12.5 cm2, 87.5 mg/25 cm2, or 175 mg/50 cm2. Serial blood samples were collected up to 312 hours after patch application. The plasma concentrations of donepezil were determined by using a validated liquid chromatography–tandem mass spectrometry method. Pharmacokinetic parameters were obtained by noncompartmental analysis. Tolerability of the patches and performance of the patches (adhesion, skin irritation, residual donepezil content in the patch were assessed throughout the study. Results: The study was completed by 36 healthy subjects. After patch application, the maximal plasma donepezil concentration (Cmax and the area under the curve (AUC increased in a dose-proportional manner. Median time to Cmax was ~74–76 hours (~2–4 hours after patch removal, and mean t1/2ß was ~63.77–93.07 hours. The average donepezil residue in the patch after 72 hours was ~73.9%–86.7% of the loading dose. There were neither serious adverse events nor adverse events that lead to discontinuation. Skin adhesion of the patch was good in 97.2% of the subjects. All skin irritations after patch removal were mild and were resolved during the study period. Conclusion: The donepezil patch

  2. Valoración del riesgo de desarrollar úlceras por presión en unidades de cuidados críticos: revisión sistemática con metaanálisis

    Directory of Open Access Journals (Sweden)

    Francisco P. García-Fernández

    2013-06-01

    Full Text Available Objetivos: identificar las escalas de valoración del riesgo de desarrollar úlceras por presión que han sido utilizadas en el contexto de los cuidados críticos. Determinar cuáles de ellas han sido validadas en función de los criterios de validez predictiva, capacidad predictiva y fiabilidad, elaborando, cuando sea posible, indicadores agregados. Métodos: revisión sistemática de la literatura científica. Se realizo una búsqueda en las 14 principales bases de datos bibliográficas internacionales de ciencias de la salud. Se incluyeron los estudios publicados entre 1962 y 2009, sin restricción idiomática, que fueran prospectivos, con pérdidas < 25%, con seguimiento sistemático y que aportaran datos de validez y/o capacidad predictiva y/o fiabilidad. Se ha excluido la literatura gris, los estudios de revisión, retrospectivos y transversales. La valoración de la calidad metodológica de los estudios se ha realizado mediante el Critical Appraisae Skills Programme (CASP. Los indicadores analizados han sido validez, magnitud de efecto (RR y fiabilidad. Resultados: se han identificado un total de 255 artículos que identifican 16 escalas de valoración del riesgo diseñadas específicamente para las UCI. Existen 26 estudios que miden la validez de las mismas. Solo tres escalas tienen más de un estudio de validación (NM Bienstein, Cubbin-Jackson, Jackson-Cubbin. Cuatro escalas generalistas también han sido validadas en UCI (Braden, Norton, BM Song-Choi y Waterlow. NM Bienstein y Waterlow no son válidas por baja sensibilidad. Cubbin-Jackson, Jackson-Cubbin y Norton presentan datos muy similares de validez y capacidad predictiva, pero con muestra muy pequeña. Braden es la escala mejor testada en las UCI, con adecuados parámetros de validez y capacidad predictiva. Conclusiones: recomendamos el uso de la escala de Braden para valorar el riesgo de desarrollar úlceras por presión en las unidades de cuidados críticos. Otras escalas como

  3. Evaluation of treatment response and resistance in metastatic renal cell cancer (mRCC) using integrated (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI); The REMAP study.

    Science.gov (United States)

    Kelly-Morland, Christian; Rudman, Sarah; Nathan, Paul; Mallett, Susan; Montana, Giovanni; Cook, Gary; Goh, Vicky

    2017-06-02

    Tyrosine kinase inhibitors are the first line standard of care for treatment of metastatic renal cell carcinoma (RCC). Accurate response assessment in the setting of antiangiogenic therapies remains suboptimal as standard size-related response criteria do not necessarily accurately reflect clinical benefit, as they may be less pronounced or occur later in therapy than devascularisation. The challenge for imaging is providing timely assessment of disease status allowing therapies to be tailored to ensure ongoing clinical benefit. We propose that combined assessment of morphological, physiological and metabolic imaging parameters using 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ((18)F-FDG PET/MRI) will better reflect disease behaviour, improving assessment of response/non-response/relapse. The REMAP study is a single-centre prospective observational study. Eligible patients with metastatic renal cell carcinoma, planned for systemic therapy, with at least 2 lesions will undergo an integrated (18)F-FDG PET and MRI whole body imaging with diffusion weighted and contrast-enhanced multiphasic as well as standard anatomical MRI sequences at baseline, 12 weeks and 24 weeks of systemic therapy allowing (18)F-FDG standardised uptake value (SUV), apparent diffusion co-efficient (ADC) and normalised signal intensity (SI) parameters to be obtained. Standard of care contrast-enhanced computed tomography CT scans will be performed at equivalent time-points. CT response categorisation will be performed using RECIST 1.1 and alternative (modified)Choi and MASS criteria. The reference standard for disease status will be by consensus panel taking into account clinical, biochemical and conventional imaging parameters. Intra- and inter-tumoural heterogeneity in vascular, diffusion and metabolic response/non-response will be assessed by image texture analysis. Imaging will also inform the development of computational methods for automated disease

  4. Nanoparticulated docetaxel exerts enhanced anticancer efficacy and overcomes existing limitations of traditional drugs

    Directory of Open Access Journals (Sweden)

    Choi J

    2015-09-01

    Full Text Available Jinhyang Choi,1,2 Eunjung Ko,1 Hye-Kyung Chung,3 Jae Hee Lee,1 Eun Jin Ju,1 Hyun Kyung Lim,4 Intae Park,1 Kab-Sig Kim,5 Joo-Hwan Lee,5 Woo-Chan Son,6 Jung Shin Lee,1,7 Joohee Jung,1,4 Seong-Yun Jeong,1,2 Si Yeol Song,1,8 Eun Kyung Choi1,3,8 1Institute for Innovative Cancer Research, 2Asan Institute for Life Sciences, 3Center for Development and Commercialization of Anti-cancer Therapeutics, 4College of Pharmacy, Duksung Women’s University, 5Bio-Synectics, 6Department of Pathology, 7Department of Internal Medicine, 8Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: Nanoparticulation of insoluble drugs improves dissolution rate, resulting in increased bioavailability that leads to increased stability, better efficacy, and reduced toxicity of drugs. Docetaxel (DTX, under the trade name Taxotere™, is one of the representative anticancer chemotherapeutic agents of this era. However, this highly lipophilic and insoluble drug has many adverse effects. Our novel and widely applicable nanoparticulation using fat and supercritical fluid (NUFS™ technology enabled successful nanoscale particulation of DTX (Nufs-DTX. Nufs-DTX showed enhanced dissolution rate and increased aqueous stability in water. After confirming the preserved mechanism of action of DTX, which targets microtubules, we showed that Nufs-DTX exhibited similar effects in proliferation and clonogenic assays using A549 cells. Interestingly, we observed that Nufs-DTX had a greater in vivo tumor growth delay effect on an A549 xenograft model than Taxotere™, which was in agreement with the improved drug accumulation in tumors according to the biodistribution result, and was caused by the enhanced permeability and retention (EPR effect. Although both Nufs-DTX and Taxotere™ showed negative results for our administration dose in the hematologic toxicity test, Nufs-DTX showed much less toxicity than Taxotere™ in

  5. 协整平滑转移回归中的线性检验——基于完全修正最小二乘法的扩展%Testing Linearity in Cointegrating Smooth Transition Regressions--Based on Fully Modified OLS

    Institute of Scientific and Technical Information of China (English)

    欧阳志刚

    2010-01-01

    在解释变量内生条件下,Choi,Saikkonen(2004)使用动态最小二乘法估计协整平滑转移回归模型,并基于动态最小二乘法的估计结果构造LMD统计量检验协整向量的非线性.本文系统解析了LMD的构造并指出其不足,针对这一不足,本文将动态最小二乘法扩展为完全修正的最小二乘法,并进而基于完全修正的最小二乘法估计结果构造LMF统计量检验协整向量的非线性.本文的仿真试验表明,在有限样本下,LMF与LMD的检验势没有显著差异,但LMF的水平扭曲小于LMD.

  6. The effect of eccentricity and spatiotemporal energy on motion silencing.

    Science.gov (United States)

    Choi, Lark Kwon; Bovik, Alan C; Cormack, Lawrence K

    2016-01-01

    The now well-known motion-silencing illusion has shown that salient changes among a group of objects' luminances, colors, shapes, or sizes may appear to cease when objects move rapidly (Suchow & Alvarez, 2011). It has been proposed that silencing derives from dot spacing that causes crowding, coherent changes in object color or size, and flicker frequencies combined with dot spacing (Choi, Bovik, & Cormack, 2014; Peirce, 2013; Turi & Burr, 2013). Motion silencing is a peripheral effect that does not occur near the point of fixation. To better understand the effect of eccentricity on motion silencing, we measured the amount of motion silencing as a function of eccentricity in human observers using traditional psychophysics. Fifteen observers reported whether dots in any of four concentric rings changed in luminance over a series of rotational velocities. The results in the human experiments showed that the threshold velocity for motion silencing almost linearly decreases as a function of log eccentricity. Further, we modeled the response of a population of simulated V1 neurons to our stimuli. We found strong matches between the threshold velocities on motion silencing observed in the human experiment and those seen in the energy model of Adelson and Bergen (1985). We suggest the plausible explanation that as eccentricity increases, the combined motion-flicker signal falls outside the narrow spatiotemporal frequency response regions of the modeled receptive fields, thereby reducing flicker visibility.

  7. Target Identification Using Harmonic Wavelet Based ISAR Imaging

    Science.gov (United States)

    Shreyamsha Kumar, B. K.; Prabhakar, B.; Suryanarayana, K.; Thilagavathi, V.; Rajagopal, R.

    2006-12-01

    A new approach has been proposed to reduce the computations involved in the ISAR imaging, which uses harmonic wavelet-(HW) based time-frequency representation (TFR). Since the HW-based TFR falls into a category of nonparametric time-frequency (T-F) analysis tool, it is computationally efficient compared to parametric T-F analysis tools such as adaptive joint time-frequency transform (AJTFT), adaptive wavelet transform (AWT), and evolutionary AWT (EAWT). Further, the performance of the proposed method of ISAR imaging is compared with the ISAR imaging by other nonparametric T-F analysis tools such as short-time Fourier transform (STFT) and Choi-Williams distribution (CWD). In the ISAR imaging, the use of HW-based TFR provides similar/better results with significant (92%) computational advantage compared to that obtained by CWD. The ISAR images thus obtained are identified using a neural network-based classification scheme with feature set invariant to translation, rotation, and scaling.

  8. Molecular Cloning and Characterization of Pollen Development Related Gene RsMF2 from Raphanus sativus L.

    Institute of Scientific and Technical Information of China (English)

    ZHANG Tao; CAO Jia-shu

    2005-01-01

    In the paper, the full length cDNA of RsMF2 gene, homologous with the BcMF2 gene encoding pollen-specific polygalacturonase of Chinese cabbage-pak-choi (Brassica campestris L. ssp. chinensis Makino) was cloned from Raphanus sativus L. cv. Yuanbai by PCR, with a pair of primer designed according to the coding sequence of BcMF2. The largest opening reading frame of RsMF2 gene is 1 266 bp in length and encodes a protein of 421 amino acids with a predicted molecular mass of 43.9 kDa. Sequence analysis revealed that it has three potential N-glycosylation sites and one polygalacturonase active position (RVTCGPGHGLSVGS). And the first 32 amino acids of the predicted RsMF2 protein form a N-terminal hydrophobic domain which displays the properties of a signal peptide. The predicted secondary structure composition for the protein has 6.9% helix, 42.0% sheet and 51.1% loop. Four domains which are highly conserved in the whole plant and fungal PGs is present in RsMF2. Phylogenetic analysis showed that RsMF2 falls into the category of clade-C, which includes PGs related to pollen. These results indicate that RsMF2 may act as polygalacturonase related to pollen development.

  9. Biomimetics: forecasting the future of science, engineering, and medicine

    Directory of Open Access Journals (Sweden)

    Hwang J

    2015-09-01

    Full Text Available Jangsun Hwang,1 Yoon Jeong,1,2 Jeong Min Park,3 Kwan Hong Lee,1,2,4 Jong Wook Hong,1,2 Jonghoon Choi1,2 1Department of Bionano Technology, Graduate School, Hanyang University, Seoul, 2Department of Bionano Engineering, Hanyang University ERICA, Ansan, Korea; 3Department of Biomedical Engineering, Boston University, 4OpenView Venture Partners, Boston, MA, USA Abstract: Biomimetics is the study of nature and natural phenomena to understand the principles of underlying mechanisms, to obtain ideas from nature, and to apply concepts that may benefit science, engineering, and medicine. Examples of biomimetic studies include fluid-drag reduction swimsuits inspired by the structure of shark’s skin, velcro fasteners modeled on burrs, shape of airplanes developed from the look of birds, and stable building structures copied from the backbone of turban shells. In this article, we focus on the current research topics in biomimetics and discuss the potential of biomimetics in science, engineering, and medicine. Our report proposes to become a blueprint for accomplishments that can stem from biomimetics in the next 5 years as well as providing insight into their unseen limitations. Keywords: biomimicry, tissue engineering, biomaterials, nature, nanotechnology, nanomedicine

  10. Digital Watermarks Using Discrete Wavelet Transformation and Spectrum Spreading

    Directory of Open Access Journals (Sweden)

    Ryousuke Takai

    2003-12-01

    Full Text Available In recent tears, digital media makes rapid progress through the development of digital technology. Digital media normally assures fairly high quality, nevertheless can be easily reproduced in a perfect form. This perfect reproducibility takes and advantage from a certain point of view, while it produces an essential disadvantage, since digital media is frequently copied illegally. Thus the problem of the copyright protection becomes a very important issue. A solution of this problem is to embed digital watermarks that is not perceived clearly by usual people, but represents the proper right of original product. In our method, the images data in the frequency domain are transformed by the Discrete Wavelet Transform and analyzed by the multi resolution approximation, [1]. Further, the spectrum spreading is executed by using PN-sequences. Choi and Aizawa [7] embed watermarks by using block correlation of DCT coefficients. Thus, we apply Discrete Cosine Transformation, abbreviated to DCT, instead of the Fourier transformation in order to embed watermarks.If the value of this variance is high then we decide that the block has bigger magnitude for visual fluctuations. Henceforth, we may embed stronger watermarks, which gives resistance for images processing, such as attacks and/or compressions.

  11. Editorial: Focus on Extra Space Dimensions

    Science.gov (United States)

    Agashe, Kaustubh; Pomarol, Alex

    2010-07-01

    Experiments at the Large Hadron Collider (LHC) have just started. In addition to verifying the Standard Model (SM) of particle physics, these experiments will probe a new energy frontier and test extensions of the SM. The existence of extra dimensions is one of the most attractive possibilities for physics beyond the SM. This focus issue contains a collection of articles addressing both theoretical and phenomenological aspects of extra-dimensional models. Focus on Extra Space Dimensions Contents Minimal universal extra dimensions in CalcHEP/CompHEP AseshKrishna Datta, Kyoungchul Kong and Konstantin T Matchev Disordered extra dimensions Karim Benakli Codimension-2 brane-bulk matching: examples from six and ten dimensions Allan Bayntun, C P Burgess and Leo van Nierop Gauge threshold corrections in warped geometry Kiwoon Choi, Ian-Woo Kim and Chang Sub Shin Holographic methods and gauge-Higgs unification in flat extra dimensions Marco Serone Soft-wall stabilization Joan A Cabrer, Gero von Gersdorff and Mariano Quirós Warped five-dimensional models: phenomenological status and experimental prospects Hooman Davoudiasl, Shrihari Gopalakrishna, Eduardo Pontón and José Santiago

  12. WHO Standard Acupuncture Point Locations

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    Sabina Lim

    2010-01-01

    Full Text Available ‘WHO Standard Acupuncture Point Locations in the Western Pacific Region (WHO Standard was released in 2008. Initially, there were 92/361 controversial acupuncture points (acupoints. Through seven informal consultations and four task force team meetings, 86 points were agreed upon among the 92 controversial acupoints, leaving 6 remaining controversial acupoints, demanding active research in the future. This will enhance the reproducibility and validity of acupuncture studies. It will also lead to a better understanding of acupuncture mechanisms in order to optimize its clinical efficacy for a range of diseases and syndromes. This book has two parts: General Guidelines for Acupuncture Point Locations and WHO Standard Acupuncture Point Locations. First of all, familiarity with the General Guidelines for Acupuncture Point Locations in this book can help the reader to understand and use the contents of this book in depth. I would like to thank all of the participating experts and scholars for this great work, who have overcome the limits of previous acupuncture references. I also appreciate the dedicated effort and harmonious leadership of Dr Choi Seung-hoon, former Regional Adviser in Traditional Medicine of Western Pacific Office, WHO.

  13. Power Quality Analysis Using Bilinear Time-Frequency Distributions

    Directory of Open Access Journals (Sweden)

    Sha'ameri AhmadZuri

    2010-01-01

    Full Text Available Abstract Bilinear time-frequency distributions (TFDs are powerful techniques that offer good time and frequency resolution of time-frequency representation (TFR. It is very appropriate to analyze power quality signals which consist of nonstationary and multi-frequency components. However, the TFDs suffer from interference because of cross-terms. Many TFDs have been implemented, and there is no fixed window or kernel that can remove the cross-terms for all types of signals. In this paper, the bilinear TFDs are implemented to analyze power quality signals such as smooth-windowed Wigner-Ville distribution (SWWVD, Choi-Williams distribution (CWD, B-distribution (BD, and modified B-distribution (MBD. The power quality signals focused are swell, sag, interruption, harmonic, interharmonic, and transient based on IEEE Std, 1159-1995. A set of performance measures is defined and used to compare the TFRs. It shows that SWWVD presents the best performance and is selected for power quality signal analysis. Thus, an adaptive optimal kernel SWWVD is designed to determine the separable kernel automatically from the input signal.

  14. Ultimate Precision of Adaptive Noise Estimation

    Science.gov (United States)

    Pirandola, Stefano; Lupo, Cosmo

    2017-03-01

    We consider the estimation of noise parameters in a quantum channel, assuming the most general strategy allowed by quantum mechanics. This is based on the exploitation of unlimited entanglement and arbitrary quantum operations, so that the channel inputs may be interactively updated. In this general scenario, we draw a novel connection between quantum metrology and teleportation. In fact, for any teleportation-covariant channel (e.g., Pauli, erasure, or Gaussian channel), we find that adaptive noise estimation cannot beat the standard quantum limit, with the quantum Fisher information being determined by the channel's Choi matrix. As an example, we establish the ultimate precision for estimating excess noise in a thermal-loss channel, which is crucial for quantum cryptography. Because our general methodology applies to any functional that is monotonic under trace-preserving maps, it can be applied to simplify other adaptive protocols, including those for quantum channel discrimination. Setting the ultimate limits for noise estimation and discrimination paves the way for exploring the boundaries of quantum sensing, imaging, and tomography.

  15. Motion in first language acquisition: Manner and Path in French and English child language*.

    Science.gov (United States)

    Hickmann, Maya; Taranne, Pierre; Bonnet, Philippe

    2009-09-01

    ABSTRACTTwo experiments compared how French vs. English adults and children (three to seven years) described motion events. Given typological properties (Talmy, 2000) and previous results (Choi & Bowerman, 1991; Hickmann, 2003; Slobin, 2003), the main prediction was that Manner should be more salient and therefore more frequently combined with Path (MP) in English than in French, particularly with four types of 'target' events, as compared to manner-oriented 'controls': motion up/down (Experiment I, N=200) and across (Experiment II, N=120), arrivals and departures (both experiments). Results showed that MP-responses (a) varied with events and increased with age in both languages, but (b) were more frequent in English at all ages with all events, and (c) were age- and event-specific among French speakers, who also frequently expressed Path or Manner alone. The discussion highlights several factors accounting for responses, with particular attention to the interplay between cognitive factors that drive language acquisition and typological properties that constrain this process from early on.

  16. Cultural Attitudes as WTP Determinants: A Revised Cultural Worldview Scale

    Directory of Open Access Journals (Sweden)

    Andy S. Choi

    2016-06-01

    Full Text Available There has been little attention paid to the systematic measurement issue of general attitudes toward human-culture relationships. This paper applied the Cultural Worldview (CW scale that was developed by Choi et al. in 2007 (published in the Journal of Cultural Economics, and investigated its dimensionality and relationship with willingness to pay (WTP for cultural heritage protection through a sequential integration between latent variables and valuation models. A case study of 997 Korean respondents was employed to examine conservation values of cultural heritage sites using discrete choice models. Confirmatory factor analyses demonstrated that this scale can be used either as a single second-order factor or four correlated factors. A more parsimonious version of the CW scale with twelve items is endorsed in this paper and the results also confirm that it is valid for use with non-Western nations. The findings support a significant attitude–WTP relationship; there was a significant role of the CW scale that reveals unobserved factors in valuation models.

  17. Sustained Local Diversity of Vibrio cholerae O1 Biotypes in a Previously Cholera-Free Country

    Directory of Open Access Journals (Sweden)

    Yan Boucher

    2016-07-01

    Full Text Available Although the current cholera pandemic can trace its origin to a specific time and place, many variants of Vibrio cholerae have caused this disease over the last 50 years. The relative clinical importance and geographical distribution of these variants have changed with time, but most remain in circulation. Some countries, such as Mexico and Haiti, had escaped the current pandemic, until large epidemics struck them in 1991 and 2010, respectively. Cholera has been endemic in these countries ever since. A recent retrospective study in mBio presents the results of more than 3 decades of V. cholerae monitoring from environmental and clinical sources in Mexico (S. Y. Choi et al., mBio 7:e02160-15, 2016, http://dx.doi.org/10.1128/mBio.02160-15. It reveals that multiple V. cholerae variants, including classical strains from the previous pandemic, as well as completely novel biotypes, have been circulating in Mexico. This discovery has important implications for the epidemiology and evolution of V. cholerae.

  18. Epilepsy Classification Framework Utilizing Joint Time-Frequency Signal Analysis and Processing

    Directory of Open Access Journals (Sweden)

    Shiva KHOSHNOUD

    2015-06-01

    Full Text Available Time Frequency Signal Analysis and Processing (TFSAP have been proposed in order to analyse the signal in both the time and the frequency domains. Electroencephalography (EEG as a time-varying frequency signal is an interesting field in which Time Frequency Distribution (TFD could be used in order to visualize the simultaneous distributions of signal energy in different physiological and pathological brain states. Particularly, epileptic signals due to their great features of seizure activity are introduced as the most attractive research field among researchers. This study outlines an investigation on two main pathologic brain states including, pre-ictal activity and seizure activity compared to normal activity. Pseudo-Wigner -Ville and Choi-William distributions are used in order to visualize the energy content of signals in these states. Different segments of brain electrical activity are analyzed using these distributions. Finally, Renyi’s entropy as an important characteristic which offer insight towards the EEG signal processing has been extracted from TFDs. The results obtained indicate that Renyi’s entropy is a high-quality discriminative feature especially in alpha and delta sub-bands of the EEG signal.

  19. Employee perceptions of 'profiled' customers' expectations.

    Science.gov (United States)

    Bebko, C P

    1998-01-01

    There has been an increasing interest in the issues of quality in service delivery. The SERVQUAL theory addresses these issues and identifies the causes of service quality problems. The practical, managerial implications of the SERVQUAL theory and model are currently being addressed (Reidenbach and Sandifer-Smallwood, 1990; Woodside, Frey and Daly, 1989; Mangold and Babakus, 1991; Webster, 1989; Day, 1992). A handful of these articles have specifically addressed the managerial implications of the SERVQUAL Gap 1 analysis: the identification of employee and management perceptions of consumer expectations (Mangold and Babakus, 1991; Headley and Choi, 1992; Bebko, 1994). Previously, none of the research had mentioned the potential problems inherent in Gap 1 analysis when the organization is faced with several "types" of customers, each with possibly different expectations. Consequently, the results of the GAP 1 analysis may not represent the true picture of employee perceptions of consumer expectations. This would have implications for the validity of the SERVQUAL instrument in assessing a service's ability to deliver quality to consumers.

  20. Optimal Performance of a Quantum Network

    CERN Document Server

    Pirandola, Stefano

    2016-01-01

    We show that the most general protocol of quantum communication between two end-points of a quantum network with arbitrary topology can be reduced to an ensemble of Choi matrices subject to local operations and classical communication. This is found by using a teleportation-based technique which applies to a wide range of quantum channels both in discrete- and continuous-variable settings, including lossy channels, quantum-limited amplifiers, dephasing and erasure channels. Thanks to this reduction, we compute the optimal rates (capacities) at which two end-points of a quantum network can transmit quantum information, distil entanglement, or distribute secret keys. These capacities are all bounded or equal to a single quantity, that we call the entanglement flux of the quantum network. As a particular case, we derive these optimal rates for the basic paradigm of a linear chain of quantum repeaters. Thus our results establish the ultimate rates for repeater-based and network-assisted quantum communications und...

  1. Recent advances in noninvasive glucose monitoring

    Directory of Open Access Journals (Sweden)

    So CF

    2012-06-01

    Full Text Available Chi-Fuk So,1 Kup-Sze Choi,1 Thomas KS Wong,2 Joanne WY Chung2,31Centre for Integrative Digital Health, School of Nursing, The Hong Kong Polytechnic University, Hong Kong, 2Department of Nursing and Health Sciences, Tung Wah College, Hong Kong, 3Department of Health and Physical Education, The Hong Kong Institute of Education, Hong KongAbstract: The race for the next generation of painless and reliable glucose monitoring for diabetes mellitus is on. As technology advances, both diagnostic techniques and equipment improve. This review describes the main technologies currently being explored for noninvasive glucose monitoring. The principle of each technology is mentioned; its advantages and limitations are then discussed. The general description and the corresponding results for each device are illustrated, as well as the current status of the device and the manufacturer; internet references for the devices are listed where appropriate. Ten technologies and eleven potential devices are included in this review. Near infrared spectroscopy has become a promising technology, among others, for blood glucose monitoring. Although some reviews have been published already, the rapid development of technologies and information makes constant updating mandatory. While advances have been made, the reliability and the calibration of noninvasive instruments could still be improved, and more studies carried out under different physiological conditions of metabolism, bodily fluid circulation, and blood components are needed.Keywords: noninvasive, glucose monitoring, diabetes mellitus, blood glucose measurement

  2. Development of a colonoscopy add-on device for improvement of the intubation process

    Directory of Open Access Journals (Sweden)

    Litten JD

    2011-12-01

    Full Text Available Jonathan D Litten1, JungHun Choi2, David Drozek31Department of Mechanical Engineering; 2Department of Mechanical Engineering and Biomedical Engineering Program; 3College of Osteopathic Medicine, Department of Specialty Medicine, Ohio University, Athens, OH, USAAbstract: A colonoscopy add-on device has been developed to reduce intubation time without modification of the current colonoscope and peripheral devices. One of the main purposes of the system is to minimize trauma caused by the distal tip of the colonoscope. The detachable sensory fixture at the end of the distal tip measures the distance between the distal tip and the colon wall in three directions, and the actuation system attached at the base of the colonoscope controls the distal tip by rotating two dial knobs. The device controls the distal tip to minimize contact between the distal tip and the colon wall, and the distal tip ideally points out the next possible lumen. A compatibility test of the infrared sensory system was carried out, and the design of the actuation system was accomplished. The system is integrated and controlled by a microprocessor. The device was tested in a silicon colon and porcine intestine. The results showed that a colonoscopist successfully reached the cecum with the aid of the colonoscopy add-on device without significant contact between the colon wall and the distal tip. The colonoscopy aid device was very helpful for the novice colonoscopist.Keywords: colonoscope, infrared sensors, intubation, trauma, colonoscopy training model

  3. Modeling and analysis of electrorheological suspensions in shear flow.

    Science.gov (United States)

    Seo, Youngwook P; Seo, Yongsok

    2012-02-14

    A model capable of describing the flow behavior of electrorheological (ER) suspensions under different electric field strengths and over the full range of shear rates is proposed. Structural reformation in the low shear rate region is investigated where parts of a material are in an undeformed state, while aligned structures reform under the shear force. The model's predictions were compared with the experimental data of some ER fluids as well as the CCJ (Cho-Choi-Jhon) model. This simple model's predictions of suspension flow behavior with subsequent aligned structure reformation agreed well with the experimental data, both quantitatively and qualitatively. The proposed model plausibly predicted the static yield stress, whereas the CCJ model and the Bingham model predicted only the dynamic yield stress. The master curve describing the apparent viscosity was obtained by appropriate scaling both axes, which showed that a combination of dimensional analysis and flow curve analysis using the proposed model yielded a quantitatively and qualitatively precise description of ER fluid rheological behavior based on relatively few experimental measurements.

  4. User experiences of wearable activity monitor among 3-6-year-old preschool children – Are children willing to wear monitor 7 days 24 hours per day?

    Directory of Open Access Journals (Sweden)

    Suvi Määttä

    2015-10-01

    This study was conducted as a part of long-term DAGIS project that aims to improve the health behaviors and diminish socioeconomic inequalities in health behaviors among preschool children in Finland. A large cross-sectional survey is conducted in autumn 2015. Children (N=800, aged 3-6 years wear Actigraph WGT3X-BT accelerometer for seven days, 24 hours per day. Simultaneously with accelerometer use, parents fill in diary with informing the user experiences of accelerometer and possible non-wearing times. Parents are advised that the child wears accelerometer 24 hours and remove the belt only when in water (e.g. in shower. The accelerometer data are checked straight after data collection. Choi (2011 wear time analyses are conducted for data. The device acceptability, compliance for wearing times and reported barriers for using accelerometer 24 hours in seven days among 3-6-year-old children are reported. Conclusions This study provides new information about the usability of wearable activity monitors among 3-6-year-old children, an age group that is less studied.

  5. Supermassive Black Hole Formation at High Redshifts via Direct Collapse in a Cosmological Context

    CERN Document Server

    Choi, Jun-Hwan; Begelman, Mitchell C

    2014-01-01

    We study the early stage of the formation of seed SMBHs via direct collapse in DM halos, in the cosmological context. We have performed high-resolution zoom-in simulations of such collapse at high redshifts, and have compared it with gas collapse within the isolated DM halo model of Choi et al. Using the AMR code ENZO, we have resolved the formation and growth of a DM halo via cold accretion of the filamentary and diffuse gas, until its virial temperature has reached $\\sim 10^4$K, atomic cooling has turned on, and collapse has ensued. We confirm our previous result that direct collapse proceeds in two stages, although, as expected, they are not as well separated. The first stage is triggered by the onset of atomic cooling, and leads to rapidly increasing accretion rate with radius, from $\\dot M\\sim 0.1\\,M_\\odot\\,{\\rm yr^{-1}}$ at the halo virial radius to a few $M_\\odot\\,{\\rm yr^{-1}}$, just inside the scale radius $R_{\\rm s}\\sim 30$pc of the NFW DM density profile. The second stage of the runaway collapse co...

  6. Accessing Secondary Markets as a Capital Source for Energy Efficiency Finance Programs: Program Design Considerations for Policymakers and Administrators

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Martin, E. Fadrhonc [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Thompson, P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-02-01

    Estimates of the total opportunity for investment in cost-effective energy efficiency in the United States are typically in the range of several hundred billion dollars (Choi Granade, et al., 2009 and Fulton & Brandenburg, 2012).1,2 To access this potential, many state policymakers and utility regulators have established aggressive energy efficiency savings targets. Current levels of taxpayer and utility bill-payer funding for energy efficiency is only a small fraction of the total investment needed to meet these targets (SEE Action Financing Solutions Working Group, 2013). Given this challenge, some energy efficiency program administrators are working to access private capital sources with the aim of amplifying the funds available for investment. In this context, efficient access to secondary market capital has been advanced as one important enabler of the energy efficiency industry “at scale.”3 The question of what role secondary markets can play in bringing energy efficiency to scale is largely untested despite extensive attention from media, technical publications, advocates, and others. Only a handful of transactions of energy efficiency loan products have been executed to date, and it is too soon to draw robust conclusions from these deals. At the same time, energy efficiency program administrators and policymakers face very real decisions regarding whether and how to access secondary markets as part of their energy efficiency deployment strategy.

  7. Sharp maximal inequalities for the moments of martingales and non-negative submartingales

    CERN Document Server

    Osȩkowski, Adam

    2012-01-01

    In the paper we study sharp maximal inequalities for martingales and non-negative submartingales: if $f$, $g$ are martingales satisfying \\[|\\mathrm{d}g_n|\\leq|\\mathrm{d}f_n|,\\qquad n=0,1,2,...,\\] almost surely, then \\[\\Bigl\\|\\sup_{n\\geq0}|g_n|\\Bigr\\|_p\\leq p\\|f\\|_p,\\qquad p\\geq2,\\] and the inequality is sharp. Furthermore, if $\\alpha\\in[0,1]$, $f$ is a non-negative submartingale and $g$ satisfies \\[|\\mathrm{d}g_n|\\leq|\\mathrm{d}f_n|\\quad and\\quad |\\mathbb{E}(\\mathrm{d}g_{n+1}|\\mathcal {F}_n)|\\leq\\alpha\\mathbb{E}(\\mathrm{d}f_{n+1}|\\mathcal{F}_n),\\qquad n=0,1,2,...,\\] almost surely, then \\[\\Bigl\\|\\sup_{n\\geq0}|g_n|\\Bigr\\|_p\\leq(\\alpha+1)p\\|f\\|_p,\\qquad p\\geq2,\\] and the inequality is sharp. As an application, we establish related estimates for stochastic integrals and It\\^{o} processes. The inequalities strengthen the earlier classical results of Burkholder and Choi.

  8. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program.

    Science.gov (United States)

    Lee, Eun Ju; Jan, Arif Tasleem; Baig, Mohammad Hassan; Ashraf, Jalaluddin Mohammad; Nahm, Sang-Soep; Kim, Yong-Woon; Park, So-Young; Choi, Inho

    2016-08-01

    Differentiation of muscle satellite cells (MSCs) involves interaction of the proteins present in the extracellular matrix (ECM) with MSCs to regulate their activity, and therefore phenotype. Herein, we report fibromodulin (FMOD), a member of the proteoglycan family participating in the assembly of ECM, as a novel regulator of myostatin (MSTN) during myoblast differentiation. In addition to having a pronounced effect on the expression of myogenic marker genes [myogenin (MYOG) and myosin light chain 2 (MYL2)], FMOD was found to maintain the transcriptional activity of MSTN Moreover, coimmunoprecipitation and in silico studies performed to investigate the interaction of FMOD helped confirm that it antagonizes MSTN function by distorting its folding and preventing its binding to activin receptor type IIB. Furthermore, in vivo studies revealed that FMOD plays an active role in healing by increasing satellite cell recruitment to sites of injury. Together, these findings disclose a hitherto unrecognized regulatory role for FMOD in MSCs and highlight new mechanisms whereby FMOD circumvents the inhibitory effects of MSTN and triggers myoblast differentiation. These findings offer a basis for the design of novel MSTN inhibitors that promote muscle regeneration after injury or for the development of pharmaceutical agents for the treatment of different muscle atrophies.-Lee, E. J., Jan, A. T., Baig, M. H., Ashraf, J. M., Nahm, S.-S., Kim, Y.-W., Park, S.-Y., Choi, I. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program.

  9. Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

  10. TIME-FREQUENCY ANALYSIS OF SURFACE MYOELECTRIC SIGNALS DURING DYNAMIC CONTRACTIONS%肌肉动态收缩期间表面肌电信号的时频分析

    Institute of Scientific and Technical Information of China (English)

    牟永阁; 彭承琳; 郑小林; 郑尔信

    2004-01-01

    介绍了用于肌肉动态收缩期间非平稳表面肌电信号的时频分析方法.用短时傅里叶变换、Wigner-Ville分布及Choi-Williams分布计算了表面肌电信号的时频分布,用于信号频率内容随时间演化的可视化观察.通过计算瞬时频谱参数,对肌肉疲劳的电表现进行量化描述.分析了反复性的膝关节弯曲和伸展运动期间从股外侧肌所记录的表面肌电信号.发现和在静态收缩过程中观察到的平均频率线性下降不同,在动态收缩期间瞬时平均频率的变化过程是非线性的并且更为复杂,且与运动的生物力学条件有关.研究表明将时频分析技术应用于动态收缩期间的表面肌电信号可以增加用传统的频谱分析技术不能得到的信息.

  11. Improvement of aquaponic performance through micro- and macro-nutrient addition.

    Science.gov (United States)

    Ru, Dongyun; Liu, Jikai; Hu, Zhen; Zou, Yina; Jiang, Liping; Cheng, Xiaodian; Lv, Zhenting

    2017-07-01

    Aquaponics is one of the "zero waste" industry in the twenty-first century, and is considered to be one of the major trends for the future development of agriculture. However, the low nitrogen utilization efficiency (NUE) restricted its widely application. To date, many attempts have been conducted to improve its NUE. In the present study, effect of micro- and macro-nutrient addition on performance of tilapia-pak choi aquaponics was investigated. Results showed that the addition of micro- and macro-nutrients improved the growth of plant directly and facilitated fish physiology indirectly, which subsequently increased NUE of aquaponics from 40.42 to 50.64%. In addition, remarkable lower total phosphorus concentration was obtained in aquaponics with micro- and macro-nutrient addition, which was attributed to the formation of struvite. Most of the added micro-nutrients were enriched in plant root, while macro-nutrients mainly existed in water. Moreover, no enrichment of micro- and macro-nutrients in aquaponic products (i.e., fish and plant leaves) was observed, indicating that it had no influence on food safety. The findings here reported manifest that appropriate addition of micro- and macro-nutrients to aquaponics is necessary, and would improve its economic feasibility.

  12. A challenging diagnosis: case report of extensive pyoderma gangrenosum at multiple sites

    Directory of Open Access Journals (Sweden)

    Ye MJ

    2014-03-01

    Full Text Available Mingwei J Ye,1,2 Joshua Mingsheng Ye,2 Leonard Wu,3 Cameron P Keating,4 Wai-Ting Choi41Department of Dermatology, Western Hospital, Footscray, VIC, Australia; 2University of Melbourne, Department of Medicine, Dentistry and Health Sciences, Parkville, VIC, Australia; 3Department of Pathology, Western Hospital, Footscray, VIC, Australia; 4Department of Plastic Surgery, Western Hospital, Footscray, VIC, AustraliaBackground: Pyoderma gangrenosum (PG is a rare dermatological condition characterized by the rapid progression of a painful, necrolytic ulcer with an irregular, undermined border and commonly affects the lower extremities, mainly in the pretibial area. The diagnosis of PG is not easy. Due to lack of diagnostic laboratory test and histopathological findings indicative of PG, it is often misdiagnosed as an infection. This results in delayed or inappropriate treatment of the condition, which leads to devastating consequences such as limb amputation and death.Main observations: We report a rare case of a 51-year-old female who was initially diagnosed as having infected ulcers and underwent serial debridements, which resulted in extensive PG at three different sites (abdominal, left thigh, and sacral.Conclusion: This case highlights the challenges in diagnosing PG, emphasizes the key clinical features to aid diagnosis, and the clinical consequences of delayed or misdiagnosis of this condition.Keywords: postoperative complication, skin ulcer, surgical wound

  13. P-type electronic and thermal transport properties of Mg2Sn1-xSix

    Science.gov (United States)

    Kim, Sunphil; Wiendlocha, Bartlomiej; Heremans, Joseph P.

    2013-03-01

    P-type Mg2Sn doped with various acceptors(1)(2) has been studied as a potential thermoelectric material. Because of its narrow band gap and high lattice thermal conductivity, the zT values of the binary compound are limited: zTmax reported is 0.3(3). In this work, we synthesize and characterize p-type-doped Mg2Sn1-xSix with various acceptors. Silicon is added in order to widen the band gap and scatter the phonons. The conduction band degeneracy that yields excellent zT in n-type material in the Mg2Sn1-xSix alloy system unfortunately does not apply to p-type material. Thermomagnetic and galvanomagnetic properties (electrical resistivity, Seebeck, Hall, and Nernst coefficients) are measured, along with thermal conductivity and band gap measurements. Finally, zT values are reported. (1) H. Y. Chen et al. Journal of Electronic Materials, Vol. 38, No. 7, 2009 (2) S. Choi et al. Journal of Electronic Materials, Vol. 41, No. 6, 2012 (3) H. Y. Chen et al. Phys. Status Solidi A 207, No. 11, 2523-2531 (2010) The work is supported by the joint NSF/DOE program on thermoelectrics, NSF-CBET-1048622

  14. The SLUGGS Survey: revisiting the correlation between X-ray luminosity and total mass of massive early-type galaxies

    CERN Document Server

    Forbes, Duncan A; Romanowsky, Aaron J; Kim, Dong-Woo; Brodie, Jean P; Fabbiano, Giuseppina

    2016-01-01

    Here we utilise recent measures of galaxy total dynamical mass and X-ray gas luminosities (L$_{X,Gas}$) for a sample of 29 massive early-type galaxies from the SLUGGS survey to probe L$_{X,Gas}$--mass scaling relations. In particular, we investigate scalings with stellar mass, dynamical mass within 5 effective radii (R$_e$) and total virial mass. We also compare these relations with predictions from $\\Lambda$CDM simulations. We find a strong linear relationship between L$_{X,Gas}$ and galaxy dynamical mass within 5 R$_e$, which is consistent with the recent cosmological simulations of Choi et al. that incorporate mechanical heating from AGN. We conclude that the gas surrounding massive early-type galaxies was shock heated as it fell into collapsing dark matter halos so that L$_{X,Gas}$ is primarily driven by the depth of a galaxy's potential well. Heating by an AGN plays an important secondary role in determining L$_{X,Gas}$.

  15. A research proposal for investigating the effect of foreign direct investments on technology transfer in the Arabian Gulf (GCC)

    Science.gov (United States)

    Tahat, Kaher; Whelan, Susan

    2015-02-01

    In terms of hosting countries perspectives, Foreign Direct Investments (FDI) could have a positive effect on its developing economy, by transferring, both: resources of finance in addition to the international technology (ITT) (Choi, 1997). Multinational companies (MNC) are engaging in the transferring of the new technology, internally as well as licensing older one; they create "Spillover" (Knowledge) for facilitating the transfer of ITT in line with geographical location, period of investment, and the type of industry. Furthermore, the effect of these spillovers depends on the level of transferring this knowledge based on FDI attraction policies of the host country (Huang, 2009). Considering the Arabian Gulf council countries (GCC) as "FDI- rich hosting countries", who are not seeking for financial resources, i.e., they already have a huge financial capacity for funding their different projects, even though FDI has been powerfully presented in GCC . They saw noticeable increases in FDI inflows beginning in 2002, (www.unctad.org.fdistatistics). Therefore by assumption, FDI inflows to GCC could positively affect their economic growth through transferring the advanced technology, in order to build up their level of technology (productivity growth) as well as their economic diversification strategy. If so how this Knowledge could be diffused and measured in order to maximize its benefit and enhancing the productivity growth, and what is the current status of (GCC).

  16. A PANEL COINTEGRATION ANALYSIS: AN APPLICATION TO INTERNATIONAL TOURISM DEMAND OF THAILAND

    Directory of Open Access Journals (Sweden)

    CHUKIAT CHAIBOONSRI

    2010-01-01

    Full Text Available This paper sought to find the long-run relationships between international tourist arrivals in Thailand and economic variables such as GDP, transportation cost and exchange rates during period of 1986 to 2007. Also this paper used five standard panel unit root tests such as LLC (2002 panel unit root test, Breitung (2000 panel unit root test, IPS (2003 panel unit root test, Maddala and Wu (1999 and Choi (2001 panel unit root test and Handri (1999 panel unit root test. Moreover, the panel cointegration test based on Pedroni residual cointegration tests, Kao residual cointegration tests and Johansen fisher panel cointegration test were used to test in panel among the variables. The OLS estimator, DOLS estimator and FMOLS estimator were used to find the long-run relationship of the international tourism demand model for Thailand.The long-run results indicated that growth in income (GDP of Thai’s Asia major tourist source markets (Malaysia, Japan, Korea, China, Singapore and Taiwan have a positive impact on international tourists arrival to Thailand. In addition, the transportation cost of these countries has negative impact on the number of international tourist arrivals to Thailand. Finally Thailand’s currency has positive impact on the number of international tourist arrivals to Thailand. Most of findings from this study were consistent with economic theory and the implications of the model can be use for policy making.

  17. Digital Watermarks Using Discrete Wavelet Transformation and Spectrum Spreading

    Directory of Open Access Journals (Sweden)

    Ryousuke Takai

    2003-12-01

    Full Text Available In recent tears, digital media makes rapid progress through the development of digital technology. Digital media normally assures fairly high quality, nevertheless can be easily reproduced in a perfect form. This perfect reproducibility takes and advantage from a certain point of view, while it produces an essential disadvantage, since digital media is frequently copied illegally. Thus the problem of the copyright protection becomes a very important issue. A solution of this problem is to embed digital watermarks that is not perceived clearly by usual people, but represents the proper right of original product. In our method, the images data in the frequency domain are transformed by the Discrete Wavelet Transform and analyzed by the multi resolution approximation, [1]. Further, the spectrum spreading is executed by using PN-sequences. Choi and Aizawa [7] embed watermarks by using block correlation of DCT coefficients. Thus, we apply Discrete Cosine Transformation, abbreviated to DCT, instead of the Fourier transformation in order to embed watermarks.If the value of this variance is high then we decide that the block has bigger magnitude for visual fluctuations. Henceforth, we may embed stronger watermarks, which gives resistance for images processing, such as attacks and/or compressions.

  18. Preserved foods and nasopharyngeal carcinoma: a case-control study in Guangxi, China.

    Science.gov (United States)

    Yu, M C; Mo, C C; Chong, W X; Yeh, F S; Henderson, B E

    1988-04-01

    One hundred twenty-eight mothers of nasopharyngeal carcinoma (NPC) cases under age 45 in Yulin Prefecture, China and 174 mothers of population controls were interviewed as part of an epidemiological study to examine childhood exposures in relation to the development of NPC. Exposure before age 2 years to a number of fermented foods was a risk factor for NPC. During weaning, intake of salted fish [relative risk (RR) = 2.6, one-sided P (P) = 0.01], salted duck eggs (RR = 5.0, P = 0.03), salted mustard green (RR = 5.4, P = 0.03), and chung choi (RR = 2.0), P = 0.003), a kind of salted root, was significantly related to an increased risk of NPC. Between ages 1 and 2 years, intake frequency of dried fish [P for linear trend test (linear trend P) = 0.002], fermented black bean paste (linear trend P = 0.0009), and fermented soy bean paste (linear trend P = 0.007) was also positively associated with NPC. A multivariate analysis of these different foods showed all except fermented black bean paste to be independently related to NPC.

  19. Thermocapillary flow of thin Cu-water nanoliquid film during spin coating process

    Science.gov (United States)

    Maity, Susanta

    2017-01-01

    Unsteady flow of thin Cu-water nanoliquid film over a horizontal rotating disk is studied numerically using finite difference technique under the assumption of planar interface. It is also assumed that the disk is cooling axisymmetrically from below. The effects of the nanolayer thickness and nanoparticle radius are considered for investigation. It is found that the film thinning rate decreases with increase of the nanoparticle volume fraction. It is also found that thickness of liquid decreases with increase of the thermocapillary parameter. The results show that the rate of film thinning is more for the thermal conductivity model of Yu and Choi [47] compared to the model of Maxwell [46]. It is observed that the film thinning rate increases with increase of nanolayer thickness but it decreases with the nanoparticle radius. A curve R=R_c(z,t) in R-z plane is delineated along which temperature gradient T_z is zero and positive or negative according to RR_c respectively. Furthermore, it is shown that the region for T_z>0 enlarges with increase of the nanoparticle volume fraction and the nanolayer thickness.

  20. Extremely long-lived magnetic excitations in supported Fe chains

    Science.gov (United States)

    Gauyacq, J. P.; Lorente, N.

    2016-07-01

    We report on a theoretical study of the lifetime of the first excited state of spin chains made of an odd number of Fe atoms on C u2N /Cu (100 ) . Yan, Choi, Burgess, Rolf-Pissarczyk, and Loth [Nat. Nanotech. 10, 40 (2015), 10.1038/nnano.2014.281] recently observed very long lifetimes in the case of F e3 chains. We consider the decay of the first excited state induced by electron-hole pair creation in the substrate. For a finite magnetic field, the two lowest-lying states in the chain have a quasi-Néel state structure. Decay from one state to the other strongly depends on the degree of entanglement of the local spins in the chain. The weak entanglement in the chain accounts for the long lifetimes that increase exponentially with chain length. Despite their apparently very different properties, the behavior of odd and even chains is governed by the same kind of phenomena, in particular entanglement effects. The present results account quite well for the lifetimes recently measured by Yan et al. on F e3 .

  1. Conditional Mutual Information of Bipartite Unitaries and Scrambling

    CERN Document Server

    Ding, Dawei; Walter, Michael

    2016-01-01

    One way to diagnose chaos in bipartite unitary channels is via the negativity of the tripartite information of the corresponding Choi state, which for certain choices of the subsystems reduces to the negative conditional mutual information (CMI). We study this quantity from a quantum information-theoretic perspective to clarify its role in diagnosing scrambling. When the CMI is zero, we find that the channel has a special normal form consisting of local channels between individual inputs and outputs. However, we find that arbitrarily low CMI does not imply arbitrary proximity to a channel of this form, although it does imply a type of approximate recoverability of one of the inputs. When the CMI is maximal, we find that the residual channel from an individual input to an individual output is completely depolarizing when the other inputs are maximally mixed. However, we again find that this result is not robust. We also extend some of these results to the multipartite case and to the case of Haar-random pure i...

  2. Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway

    Directory of Open Access Journals (Sweden)

    Choi SY

    2015-07-01

    Full Text Available Seon Young Choi,1 Min Seok Song,1 Pan Dong Ryu,1 Anh Thu Ngoc Lam,2 Sang-Woo Joo,2 So Yeong Lee1 1Laboratory of Veterinary Pharmacology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 2Department of Chemistry, Soongsil University, Seoul, South Korea Abstract: Gold nanoparticles (AuNPs are attractive materials for use in biomedicine due to their physical properties. Increasing evidence suggests that several nanoparticles induce the differentiation of human mesenchymal stem cells into osteoblasts and adipocytes. In this study, we hypothesized that chitosan-conjugated AuNPs promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells. For the evaluation of osteogenic differentiation, alizarin red staining, an alamarBlue® assay, and a quantitative real-time polymerase chain reaction analysis were performed. In order to examine specific signaling pathways, immunofluorescence and a western blotting assay were performed. Our results demonstrate that chitosan-conjugated AuNPs increase the deposition of calcium content and the expression of marker genes related to osteogenic differentiation in human adipose-derived mesenchymal stem cells at nontoxic concentrations. These results indicate that chitosan-conjugated AuNPs promote osteogenesis through the Wnt/β-catenin signaling pathway. Therefore, chitosan-conjugated AuNPs can be used as a reagent for promoting bone formation. Keywords: chitosan-conjugated gold nanoparticle, mineralization, nonphosphorylated beta-catenin

  3. Are all ostracism experiences equal? A comparison of the autobiographical recall, Cyberball, and O-Cam paradigms.

    Science.gov (United States)

    Godwin, Alexandra; MacNevin, Georgia; Zadro, Lisa; Iannuzzelli, Rose; Weston, Stephanie; Gonsalkorale, Karen; Devine, Patricia

    2014-09-01

    In the present study, we aimed to compare the primary-need depletion elicited by three common ostracism paradigms: autobiographical recall (e.g., Zhong & Leonardelli in Psychological Science 19:838-842, 2008), Cyberball (Williams, Cheung, & Choi in Journal of Personality and Social Psychology 79:748-762, 2000), and O-Cam (Goodacre & Zadro in Behavior Research Methods 42:768-774, 2010). A total of 152 participants (52 males) were randomly allocated to one of the three paradigms, and their subsequent primary needs were measured (belonging, control, self-esteem, and meaningful existence). O-Cam was found to induce greater total primary-need depletion than did Cyberball and recall, which did not differ significantly from each other. Moreover, when examining the pattern of individual need depletion elicited by each paradigm, O-Cam was found to induce significantly greater depletion of belonging, control, and meaningful existence than did the recall paradigm, and significantly greater depletion of control and self-esteem than did Cyberball. No other comparisons were found to be significant, including the comparisons between the recall and Cyberball paradigms for each individual primary need. Collectively, the findings will assist ostracism researchers in making informed choices regarding (a) which paradigm is appropriate to implement with respect to their research aims, and (b) whether the interchangeable use of paradigms within a program of research is appropriate practice.

  4. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543

    Directory of Open Access Journals (Sweden)

    Jouni Jokela

    2017-10-01

    Full Text Available Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds. Here we report the production of hepatotoxins and new protease inhibitors from benthic Nostoc sp. CENA543 isolated from a small, shallow, saline-alkaline lake in the Nhecolândia, Pantanal wetland area in Brazil. Nostoc sp. CENA543 produces exceptionally high amounts of nodularin-R. This is the first free-living Nostoc that produces nodularin at comparable levels as the toxic, bloom-forming, Nodularia spumigena. We also characterized pseudospumigins A–F, which are a novel family of linear tetrapeptides. Pseudospumigins are structurally related to linear tetrapeptide spumigins and aeruginosins both present in N. spumigena but differ in respect to their diagnostic amino acid, which is Ile/Leu/Val in pseudospumigins, Pro/mPro in spumigins, and Choi in aeruginosins. The pseudospumigin gene cluster is more similar to the spumigin biosynthetic gene cluster than the aeruginosin gene cluster. Pseudospumigin A inhibited trypsin (IC50 4.5 μM after 1 h in a similar manner as spumigin E from N. spumigena but was almost two orders of magnitude less potent. This study identifies another location and environment where the hepatotoxic nodularin has the potential to cause the death of eukaryotic organisms.

  5. Silica-graphene oxide hybrid composite particles and their electroresponsive characteristics.

    Science.gov (United States)

    Zhang, Wen Ling; Choi, Hyoung Jin

    2012-05-01

    Silica-graphene oxide (Si-GO) hybrid composite particles were prepared by the hydrolysis of tetraethyl orthosilicate (TEOS) in the presence of hydrophilic GO obtained from a modified Hummers method. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images provided visible evidence of the silica nanoparticles grafted on the surface of GO, resulting in Si-GO hybrid composite particles. Energy dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD) spectra indicated the coexistence of silica and GO in the composite particles. The Si-GO hybrid composite particles showed better thermal stability than that of GO according to thermogravimetric analysis (TGA). The electrorheological (ER) characteristics of the Si-GO hybrid composite based ER fluid were examined further by optical microscopy and a rotational rheometer in controlled shear rate mode under various electric field strengths. Shear stress curves were fitted using both conventional Bingham model and a constitutive Cho-Choi-Jhon model. The polarizability and relaxation time of the ER fluid from dielectric spectra measured using an LCR meter showed a good correlation with its ER characteristics.

  6. Quantitative Trait Locus Analysis of Seed Germination and Seedling Vigor in Brassica rapa Reveals QTL Hotspots and Epistatic Interactions.

    Science.gov (United States)

    Basnet, Ram K; Duwal, Anita; Tiwari, Dev N; Xiao, Dong; Monakhos, Sokrat; Bucher, Johan; Visser, Richard G F; Groot, Steven P C; Bonnema, Guusje; Maliepaard, Chris

    2015-01-01

    The genetic basis of seed germination and seedling vigor is largely unknown in Brassica species. We performed a study to evaluate the genetic basis of these important traits in a B. rapa doubled haploid population from a cross of a yellow-seeded oil-type yellow sarson and a black-seeded vegetable-type pak choi. We identified 26 QTL regions across all 10 linkage groups for traits related to seed weight, seed germination and seedling vigor under non-stress and salt stress conditions illustrating the polygenic nature of these traits. QTLs for multiple traits co-localized and we identified eight hotspots for quantitative trait loci (QTL) of seed weight, seed germination, and root and shoot lengths. A QTL hotspot for seed germination on A02 mapped at the B. rapa Flowering Locus C (BrFLC2). Another hotspot on A05 with salt stress specific QTLs co-located with the B. rapa Fatty acid desaturase 2 (BrFAD2) locus. Epistatic interactions were observed between QTL hotspots for seed germination on A02 and A10 and with a salt tolerance QTL on A05. These results contribute to the understanding of the genetics of seed quality and seeding vigor in B. rapa and can offer tools for Brassica breeding.

  7. Limiting amplitudes of fully nonlinear interfacial tides and solitons

    Science.gov (United States)

    Aguiar-González, Borja; Gerkema, Theo

    2016-08-01

    A new two-fluid layer model consisting of forced rotation-modified Boussinesq equations is derived for studying tidally generated fully nonlinear, weakly nonhydrostatic dispersive interfacial waves. This set is a generalization of the Choi-Camassa equations, extended here with forcing terms and Coriolis effects. The forcing is represented by a horizontally oscillating sill, mimicking a barotropic tidal flow over topography. Solitons are generated by a disintegration of the interfacial tide. Because of strong nonlinearity, solitons may attain a limiting table-shaped form, in accordance with soliton theory. In addition, we use a quasi-linear version of the model (i.e. including barotropic advection but linear in the baroclinic fields) to investigate the role of the initial stages of the internal tide prior to its nonlinear disintegration. Numerical solutions reveal that the internal tide then reaches a limiting amplitude under increasing barotropic forcing. In the fully nonlinear regime, numerical experiments suggest that this limiting amplitude in the underlying internal tide extends to the nonlinear case in that internal solitons formed by a disintegration of the internal tide may not reach their table-shaped form with increased forcing, but appear limited well below that state.

  8. Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma: Report of a Rare Case and Literature Review

    Directory of Open Access Journals (Sweden)

    Markus K. Schuler

    2013-01-01

    Full Text Available Background. Pleomorphic sarcoma is an aggressive soft tissue sarcoma. In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported. To our knowledge, this is the first report in the literature of the neoadjuvant use of trabectedin in a patient with high-grade pleomorphic sarcoma, ineligible for standard neoadjuvant combination therapy with an anthracycline-based regimen. Case Presentation. Here we present a 58-year-old White male with a large tumor in the left thigh, but with no signs of metastases. Owing to the history of severe heart attack, three cycles of neoadjuvant trabectedin were administrated to achieve surgically wide margins. After two cycles, an 18F-FDG-PET showed a large proportion of the central tumor area was without metabolic activity. According to RECIST and Choi criteria, the tumor was stable. After the third cycle of trabectedin, the patient underwent a complete resection, which revealed completely necrotic high-grade pleomorphic sarcoma (stage pT2b, with only a small vital area. Conclusion. The present paper on a promising treatment with neoadjuvant trabectedin of patients with high-grade pleomorphic sarcoma might suggest that such treatment approach may provide a greater chance of cure and survival of such patients.

  9. Path properties of lp-valued Gaussian random fields

    Institute of Scientific and Technical Information of China (English)

    Yong-Kab; CHOI

    2007-01-01

    [1]Csáki E,Cs(o)rg(o) M.Inequalities for increments of stochastic processes and moduli of continuity.Ann Probab,20:1031-1052 (1992)[2]Csáki E,Cs(o)rg(o) M,Shao Q M.Fernique type inequalities and moduli of continuity for l2-valued Ornstein-Uhlenbeck Processes.Ann In st Henri Poincare Probabilities et Statistiques,28:479-517 (1992)[3]Csáki E,Cs(o)rg(o) M,Shao Q M.Moduli of continuity for lp-valued Gaussian processes.Acta Sci Math,60:149-175 (1995)[4]Cs(o)rg(o) M,Shao Q M.Strong limit theorems for large and small increments of lp-valued Gaussian Processes.Ann Probab,21:1958-1990 (1993)[5]Cs(o)rg(o) M,Shao Q M.On almost sure limit inferior for B-valued stochastic processes and applications.Probab Theory & Rel Fields,99:29-54 (1994)[6]Lin Z Y,Quin Y C.On the increments of l∞-valued Gaussian processes.In:Szyszkowicz B,ed.Asymptotic Methods in Probability and Statistics.Elsevier Science B V,1998,293-302[7]Choi Y K.Erd(o)s-Rényi-type laws applied to Gaussian processes.J Math Kyoto Univ,31(3):191-217(1991)[8]Csáki E,Cs(o)rg(o) M,Lin Z Y,et al.On infinite series of independent Ornstein-uhlenbeck processes.Stoch Proc & their Appl,39:25-44 (1991)[9]Cs(o)rg(o) M,Révész P.How big are the increments of a Wiener process? Ann Probab,7(4):731-737 (1979)[10]Cs(o)rg(o) M,Révész P.Strong Approximations in Probability and Statistics.New York:Academic Press,1981[11]Lin Z Y,Lu C R.Strong Limit Theorems.Hong Kong:Kluwer Academic Publ,1992[12]Ortega J.On the size of the increments of non-stationary Gaussian processes.Stoch Proc & Their Appl,18:47-56 (1984)[13]Zhang L X.A note on liminfs for increments of a fractional Brownian motion.Acta Math Hungar,76:145-154 (1997)[14]K(o)no N.The exact modulus of continuity for Gaussian processes taking values of finite dimensional normed space.Trends in Probab & Related Analysis,SAP'96.Singapore:World Scientific,1996.pp.219-232[15]Lin Z Y,Hwang K S.On the increments of a d-dimensional Gaussian process.J Korean Math Soc,42(6):1215-1230 (2005

  10. [Development of a cultivation technology and selection of leaf vegetable cultures for space greenhouse].

    Science.gov (United States)

    Levinskikh, M A; Signalova, O B; Derendiaeva, T A; Livanskaia, O G; Nefedova, E L; Sychev, V N; Podo'skiĭ, I G

    2001-01-01

    We plan to perform space experiments on development of a technology for cultivation of leaf vegetables that might be a component of future life support systems for space crews. For this purpose, we are going to fly research greenhouses with the crop area from 0.03 up to 0.1 m2 inside the universal docking module of the ISS Russian segment. To prepare for future space experiments, ground investigations were made in order to compare crop capacity of various artificial soils used to grow leaf vegetables in greenhouse Svet. Useful life of root module Svet can be extended with a new technology based on resupply of fibrous substrate with nutrients. The most effective volume of soil per a plant was determined which sustains high productivity of leaf vegetables in Svet. To select leaf vegetables for in-space cultivation, we conducted investigations of productivity, morphometric and biochemical characteristics, and palatability of 18 cultures including alternative greens highly popular in Japan and China which have been earlier tested neither in laboratory nor in space within the closed eco-system projects. We would prioritize mizuna, pak choi, tatsoi, rapina or broccoli raab, and red giant mustard as objects for in-space investigations.

  11. A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Choi J

    2014-05-01

    Full Text Available Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD, Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Biomedical Engineering, University of Science and Technology, Seoul, Republic of KoreaAbstract: Mesenchymal stem cells (MSCs have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.Keywords: mesenchymal stem cell, T cell, microwell array

  12. Olanzapine use in a manic patient during second and third trimester pregnancy

    Directory of Open Access Journals (Sweden)

    Choi L

    2014-02-01

    Full Text Available Lynn Choi, Soo-Hyun Joo, Jong-Hyun Jeong Department of Psychiatry, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea Abstract: Women with bipolar disorder have a high risk for symptom exacerbation during pregnancy and the risk is elevated further when mood stabilizers are discontinued. This report describes a 31-year-old bipolar woman who discontinued medication before pregnancy but had to resume her pharmacotherapy due to manic episodes that recurred during the second trimester. Olanzapine, an atypical antipsychotic, was administered from week 25 of gestation and then replaced with quetiapine in week 35 of gestation. Even though a consensus on clinical interventions for pregnant patients with symptom relapse has not been reached, clinicians should still discuss pregnancy and therapeutic management with every female bipolar patient of childbearing age. This discussion is important because treatment can be managed most effectively in these individuals if pregnancy is planned. Ultimately, clinical decisions should be made on a case-by-case basis, weighing the risks to the mother and fetus between the disorder itself and the teratogenicity of pharmacotherapy. Keywords: pregnancy, bipolar disorder, olanzapine, manic

  13. Efficacy and safety of gonadotropin-releasing hormone agonists used in the treatment of prostate cancer

    Directory of Open Access Journals (Sweden)

    Choi S

    2011-12-01

    Full Text Available Seungtaek Choi, Andrew K LeeDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USAAbstract: Androgen deprivation therapy (ADT is the most effective systemic treatment for prostate cancer. ADT has been shown to have a high rate of response and to improve overall survival in patients with metastatic prostate cancer. In addition, multiple studies have shown that adding ADT to external beam radiation therapy leads to improvement in cure rates and overall survival in prostate cancer patients. The most commonly used ADT is gonadotropin-releasing hormone (GnRH agonist therapy. Although GnRH agonist therapy has significant benefits for patients with prostate cancer, it has also been shown to have significant side effects, including fatigue, hot flashes, decreased libido, decreased quality of life, obesity, diabetes mellitus, coronary artery disease, decreased bone mineral density, and increased risk of fractures. Therefore, it is crucial that the benefits of ADT be weighed against its potential adverse effects before its use.Keywords: androgen deprivation therapy, gonadotropin-releasing hormone agonists, prostate cancer

  14. Vacuum-assisted Fluid Flow in Microchannels to Pattern Substrates and Cells

    Science.gov (United States)

    Shrirao, Anil B.; Kung, Frank H.; Yip, Derek; Cho, Cheul H.; Townes-Anderson, Ellen

    2014-01-01

    Substrate and cell patterning are widely used techniques in cell biology to study cell-to-cell and cell-to-substrate interactions. Conventional patterning techniques work well only with simple shapes, small areas and selected bio-materials. This paper describes a method to distribute cell suspensions as well as substrate solutions into complex, long, closed (dead-end) polydimethylsiloxane (PDMS) microchannels using negative pressure. Our method builds upon a previous vacuum-assisted method used for micromolding (Jeon, Choi et al. 1999) and successfully patterned collagen-I, fibronectin and Sal-1 substrates on glass and polystyrene surfaces, filling microchannels with lengths up to 120 mm and covering areas up to 13 × 10 mm2. Vacuum-patterned substrates were subsequently used to culture mammalian PC12 and fibroblast cells and amphibian neurons. Cells were also patterned directly by injecting cell suspensions into microchannels using vacuum. Fibroblast and neuronal cells patterned using vacuum showed normal growth and minimal cell death indicating no adverse effects of vacuum on cells. Our method fills reversibly sealed PDMS microchannels. This enables the user to remove the PDMS microchannel cast and access the patterned biomaterial or cells for further experimental purposes. Overall, this is a straightforward technique that has broad applicability for cell biology. PMID:24989641

  15. Wavelets with Ridges: A High-Resolution Representation of Cataclysmic Variable Time-Series

    CERN Document Server

    Blackman, Claire

    2010-01-01

    Quasi-periodic oscillations and dwarf nova oscillations occur in dwarf novae and nova-like variables during outburst and occasionally during quiescence, and have analogues in high-mass X-ray binaries and black-hole candidates. The frequent low coherence of quasi-period oscillations and dwarf nova oscillations can make detection with standard time-series tools such as periodograms problematic. This paper develops tools to analyse quasi-periodic brightness oscillations. We review the use of time-frequency representations in the astronomical literature, and show that representations such as the Choi-Williams Distribution and Zhao-Atlas-Marks Representation, which are best suited to high signal-to-noise data, cannot be assumed a priori to be the best techniques for our data, which have a much higher noise level and lower coherence. This leads us to a detailed analysis of the time-frequency resolution and statistical properties of six time-frequency representations. We conclude that the wavelet scalogram, with the...

  16. Host plant suitability and feeding preferences of the grapevine pest Abagrotis orbis (Lepidoptera: Noctuidae).

    Science.gov (United States)

    Mostafa, A M; Lowery, D T; Jensen, L B M; Deglow, E K

    2011-12-01

    Thirteen plant species were tested for their suitability as hosts for Abagrotis orbis (Grote), a climbing cutworm pest of grapevines in British Columbia. Choice tests were also conducted to investigate larval feeding preferences for the Brassicaceae species joi choi, Brassica rapa variety. Chinensis L., spring draba; Draba verna L.; and shepherd's purse, Capsella bursa-pastoris (L.) Medik; compared with postdormant buds of grape, Vitis vinifera L. (Vitaceae), and leaves of nine other plant species from several families. Results showed that tah tsai, Brassica rapa L. variety rosularis (M. Tsen & S. H. Lee) Hanelt (Brassicaceae), is a superior host for A. orbis based on shorter time to adult eclosion, heavier pupae, and higher rates of survival. Later-instar larvae died when fed draba, whereas those reared on shepherd's purse did not survive beyond the third instar. White clover, Trifolium repens L. (Fabaceae), and grape leaves were unsuitable hosts throughout development. Fifth-instar A. orbis preferred plants of the Brassicaceae family, dandelion, Taraxacum officinale Weber (Asteraceae), and strawberry, Fragaria sp. L. (Rosaceae), compared with postdormant grape buds. The results of this study suggest that the winter annual mustards draba and shepherd's purse that often grow abundantly in vine rows might help reduce climbing cutworm damage to the buds of grapevines.

  17. Protein distributions from a stochastic model of the lac operon of E. coli with DNA looping: analytical solution and comparison with experiments.

    Directory of Open Access Journals (Sweden)

    Krishna Choudhary

    Full Text Available Although noisy gene expression is widely accepted, its mechanisms are subjects of debate, stimulated largely by single-molecule experiments. This work is concerned with one such study, in which Choi et al., 2008, obtained real-time data and distributions of Lac permease in E. coli. They observed small and large protein bursts in strains with and without auxiliary operators. They also estimated the size and frequency of these bursts, but these were based on a stochastic model of a constitutive promoter. Here, we formulate and solve a stochastic model accounting for the existence of auxiliary operators and DNA loops. We find that DNA loop formation is so fast that small bursts are averaged out, making it impossible to extract their size and frequency from the data. In contrast, we can extract not only the size and frequency of the large bursts, but also the fraction of proteins derived from them. Finally, the proteins follow not the negative binomial distribution, but a mixture of two distributions, which reflect the existence of proteins derived from small and large bursts.

  18. On the nature of magnetic cycles at different ages of stars

    CERN Document Server

    Oláh, K; Petrovay, K; Soon, W; Baliunas, S; Kolláth, Z; Vida, K

    2016-01-01

    We study the different patterns of interannual magnetic variability in stars on or near the lower main sequence, approximately solar-type (G-K dwarf) stars in time series of 36 years from the Mount Wilson Observatory Ca\\,{\\sc ii}\\,H\\&K survey. Our main aim is to search for correlations between cycles, activity measures and ages. Time-frequency analysis has been used to discern and reveal patterns and morphology of stellar activity cycles, including multiple and changing cycles, in the datasets. Both the results from short-term Fourier transform and its refinement using the Choi-Williams distribution, with better frequency resolution, are presented in this study. Rotational periods of the stars were derived using multi-frequency Fourier analysis.From the studied 29 stars we found at least one activity cycle on 28 of them. Twelve stars, with longer rotational periods ($39.7\\pm6.0$ days) have simple, smooth cycles, and the rest of the stars, with on-average much faster rotation ($18.1\\pm12.2$ days) show comp...

  19. Characteristics of tip-leakage flow in an axial fan

    Science.gov (United States)

    Park, Keuntae; Choi, Haecheon; Choi, Seokho; Sa, Yongcheol

    2014-11-01

    An axial fan with a shroud generates complicated vortical structures by the interaction of the axial flow with the fan blades and shroud near the blade tips. Large eddy simulation (LES) is performed for flow through a forward-swept axial fan, operating at the design condition of Re = 547,000 based on the radius of blade tip and the tip velocity. A dynamic global model (Lee et al. 2010) is used for a subgrid-scale model, and an immersed boundary method in a non-inertial reference frame (Kim & Choi 2006) is adopted for the present simulation. It is found that two vortical structures are formed near the blade tip: the main tip leakage vortex (TLV) and the auxiliary TLV. The main TLV is initiated near the leading edge, develops downstream, and impinges on the pressure surface of the next blade, where the pressure fluctuations and turbulence intensity become high. On the other hand, the auxiliary TLV is initiated at the aft part of the blade but is relatively weak such that it merges with the main TLV. Supported by the KISTI Supercomputing Center (KSC-2014-C2-014).

  20. Regional Deprivation Index and Socioeconomic Inequalities Related to Infant Deaths in Korea.

    Science.gov (United States)

    Yun, Jae-Won; Kim, Young-Ju; Son, Mia

    2016-04-01

    Deprivation indices have been widely used to evaluate neighborhood socioeconomic status and therefore examine individuals within their regional context. Although some studies on the development of deprivation indices were conducted in Korea, additional research is needed to construct a more valid and reliable deprivation index. Therefore, a new deprivation index, named the K index, was constructed using principal component analysis. This index was compared with the Carstairs, Townsend and Choi indices. A possible association between infant death and deprivation was explored using the K index. The K index had a higher correlation with the infant mortality rate than did the other three indices. The regional deprivation quintiles were unequally distributed throughout the country. Despite the overall trend of gradually decreasing infant mortality rates, inequalities in infant deaths according to the deprivation quintiles persisted and widened. Despite its significance, the regional deprivation variable had a smaller effect on infant deaths than did individual variables. The K index functions as a deprivation index, and we may use this index to estimate the regional socioeconomic status in Korea. We found that inequalities in infant deaths according to the time trend persisted. To reduce the health inequalities among infants in Korea, regional deprivation should be considered.

  1. Factors influencing post-traumatic stress in Korean forensic science investigators.

    Science.gov (United States)

    Yoo, Yang-Sook; Cho, Ok-Hee; Cha, Kyeong-Sook; Boo, Yun-Jeong

    2013-09-01

    The aim of this study was to understand factors that influence post-traumatic stress (PTS) in Korean forensic science investigators. A total of 111 forensic science investigators were recruited in Korea. PTS was measured using the tool modified by Choi (2001) from the original developed by Foa, Riggs, Dancu, and Rothbaum (1993) based on DSM-IV. Factors influencing PTS included demographic and job-related characteristics, emotional intelligence, and death anxiety. PTS scores were positively correlated with personality type, fatigue from work, and death anxiety. PTS scores were negatively correlated with length of career as a forensic science investigator and emotional intelligence. The factors that had the greatest influence on PTS were death anxiety, years spent as a forensic science investigator, personality type, emotional intelligence, fatigue, and homicide experience. The explanatory power of these six factors was 44.0%. Therefore, it is necessary to regularly evaluate the mental health of those who are vulnerable to PTS. Based on these results, various interventions could be implemented for promoting overall health of the forensic science investigators. Copyright © 2013. Published by Elsevier B.V.

  2. EQUIVALENCIA DEL ESPESOR DE ENSUCIAMIENTO CON β-lg DESNATURALIZADA EN EL CALENTAMIENTO DE LECHE

    Directory of Open Access Journals (Sweden)

    Heriberto Molina Pérez

    2015-01-01

    Full Text Available En este trabajo se presenta un a estrategia para relacionar ,a través de un modelo matemático, el espesor de ensuciamiento de alimentos lácteos y la concentración de β - lg (β - lactoglobulina desnaturali zada . El planteamiento incluye , por una parte,la simulaci ón dinámica de ensuciamiento y, por otra, la generación de β - lg desnaturalizada bajo un modelo cinético. En ambos caso s se realizó un balance de energía en estado transitorio que incluye los cálculos del coeficiente global , de forma rigurosa, y de las propiedades, bajo el modelo de Choi - Okos. La solución de fue obtenida usando Runge - Kut ta 4to orden bajo código propio en una Macro de Excel en Visual Basic . La equivalencia concluyó con un modelo obtenido por regresión múltipl e no - lineal que relaciona la concentración de β - lg desnaturalizada y el espesor de ensuciamiento . Esta metodología es aplicable en el análisis de limpieza de equipos donde la cinética de limpieza puede obtener equivalencia con el avance de la reducción del espesor de ensuciamiento .

  3. Elongation Factor P Interactions with the Ribosome Are Independent of Pausing.

    Science.gov (United States)

    Tollerson, Rodney; Witzky, Anne; Ibba, Michael

    2017-08-01

    Bacterial elongation factor P (EF-P) plays a pivotal role in the translation of polyproline motifs. To stimulate peptide bond formation, EF-P must enter the ribosome via an empty E-site. Using fluorescence-based single-molecule tracking, Mohapatra et al. (S. Mohapatra, H. Choi, X. Ge, S. Sanyal, and J. C. Weisshaar, mBio 8:e00300-17, 2017, https://doi.org/10.1128/mBio.00300-17) monitored the cellular distribution of EF-P and quantified the frequency of association between EF-P and the ribosome under various conditions. Findings from the study showed that EF-P has a localization pattern that is strikingly similar to that of ribosomes. Intriguingly, EF-P was seen to bind ribosomes more frequently than the estimated number of pausing events, indicating that E-site vacancies occur even when ribosomes are not paused. The study provides new insights into the mechanism of EF-P-dependent peptide bond formation and the intricacies of translation elongation. Copyright © 2017 Tollerson et al.

  4. A NEW SPECIES OF VOLUCELLA GEOFFROY, 1762 FROM CHINA (DIPTERA,SYRPHISAE)%中国蜂蚜蝇属一新种记述(食蚜蝇科,蜂蚜蝇族)

    Institute of Scientific and Technical Information of China (English)

    霍科科; 余治家; 王新辅

    2009-01-01

    记述采自中国宁夏回族自治区六盘山自然保护区蜂蚜蝇属1新种:六盘山蜂蚜蝇Volucdla livpanshanensis sp. nov..新种近似Volucella thompsoni Choi et al.,2006.新种雄性复眼接缝长,约等于额长,腹部第3背板前缘具狭横斑,第4背板后缘向前凹入,使生殖后节背面可见;雌性复眼被毛极稀疏,腹部第3背板前缘具黄白色狭横带.模式标本保存于陕西理工学院动植物标本馆.黑蜂蚜蝇V.nigricans和黄盾蜂蚜蝇V.pellucens tabanoides为宁夏首次记录.文中给出新种描述、特征图和种团分类检索表.%In the paper, a new species of Volucella Geoffroy, 1762 is described from Liupanshan Natural Reserve, Ningxia Hui Autonomous Region: Volucella livpanshanensis sp. nov. The type specimens are held in the Museum of Animal and Botany, Shaanxi University of Technology. During the investigation Volucella nigricans and Volucella pellucens tabanoides are recorded for the first from Ningxia Hni Autonomous Region.

  5. The relationship of trait to state motivation: the role of self-competency beliefs.

    Science.gov (United States)

    Choi, Kee-Hong; Saperstein, Alice M; Medalia, Alice

    2012-08-01

    Even when people with schizophrenia describe themselves as generally motivated and eager to engage in activities, they may not actually be motivated in the present moment. In order to better understand the relationship between trait and state motivation, we aimed to assess trait motivation and state intrinsic motivation, and investigate their relations to each other and to criterion-related variables including cognition, negative symptoms, and beliefs about one's own competency-also known as perceived competency (PC). Further, we investigated whether PC mediates the relationships between state intrinsic motivation (IM) and trait motivation dimensions. Forty individuals with schizophrenia or schizoaffective disorders were administered two self-report measures of motivation, the Motivational Trait Questionnaire (Kanfer, R., Ackerman, P., 2000. Individual differences in work motivation: further explorations of a trait framework. Appl. Psychol. 49 (3), 470-482) and the Intrinsic Motivation Inventory for Schizophrenia Research (Choi, J., Medalia, A., 2010. Intrinsic motivation and learning in a schizophrenia spectrum sample. Schizophr. Res. 118, 12-19), as well as measures of PC, cognition and symptoms. The results showed that in people with schizophrenia, trait approach motivation, but not trait avoidance motivation, is positively correlated with state intrinsic motivation and PC. There was evidence that PC partially mediates the relationship between trait approach motivation and state intrinsic motivation to do the task. These results support the role of therapies that directly address self-competency beliefs and set the groundwork for future investigations on the impact of such treatments on motivation.

  6. Image, Precariousness and the Logic of Cultural Production in Hong Kong

    Directory of Open Access Journals (Sweden)

    Carolyn Cartier

    2013-01-01

    Full Text Available Interpretations of culture in Hong Kong have tended to portray the city in terms of the vanishing present, in some combination of the instant, fleeting and disappearing. This article redresses such language of lack to consider instead how the idea of precariousness in the realm of the cultural has been less a condition of cultural production than a cultural strategy. Street art, including alternative performance art and political graffiti, has made the city itself the site of roving cultural production: walls, street surfaces and passageways accommodate forms of expression that the city’s cultural institutions have only more recently and uneasily embraced. In these different modes of time-space, contemporary alternative art occupies transitory territory and locates its ‘precariousness’ in lack of definitive status and uncertain future – mimetic conditions of defining culture in Hong Kong society itself. Its measures, by contrast, emerge in Jacques Rancière’s distribution of the sensible: the ways in which they render what is visible, knowable and ultimately sayable. As objects generating negotiation, such contemporary cultural projects anticipate instabilities of the present, identify hegemonic political economic logics and seek modes of resistance. Within these perspectives, this discussion juxtaposes two simultaneous events: the exhibit ‘Memories of King Kowloon’ on the historic graffiti of Tsang Tsou-choi, and the stenciled graffiti of Ai Weiwei in public space during April and May 2011.

  7. The ATLAS Event Index: The Architecture of the Core Engine

    CERN Document Server

    Barberis, Dario; The ATLAS collaboration; Hrivnac, Julius

    2017-01-01

    The global view of the ATLAS Event Index system has been presented in the last ACAT. This talk will concentrate on the architecture of the system core component. This component handles the final stage of the event metadata import, it organizes its storage and provides a fast and feature-rich access to all information. A user is able to interrogate metadata in various ways, including by executing user-provided code on the data to make selections and to interpret the results. A wide spectrum of clients is available, from a set of linux-like commands to an interactive graphical Web Service. The stored event metadata contain the basic description of the related events, the references to the experiment event storage, the full trigger record and can be extended with other event characteristics. Derived collections of events can be created. Such collections can be annotated and tagged with further information. This talk will describe all system sub-components and their development evolution, which lead into the choi...

  8. Developing brief fatigue short forms calibrated to a common mathematical metric: is content-balancing important?

    Directory of Open Access Journals (Sweden)

    Karon F Cook

    2010-08-01

    Full Text Available Karon F Cook1, Seung W Choi2, Kurt L Johnson1, Dagmar Amtmann11Department of Rehabilitation Medicine, University of Washington, Seattle, WA; 2Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: There are clinical and research settings in which concerns about respondent burden make the use of longer self-report measures impractical. Though computer adaptive testing provides an efficient strategy for measuring patient reported outcomes, the requirement of a computer interface makes it impractical for some settings. This study evaluated how well brief short forms, constructed from a longer measure of patient reported fatigue, reproduced scores on the full measure. When the items of an item bank are calibrated using an item response theory model, it is assumed that the items are fungible units. Theoretically, there should be no advantage to balancing the content coverage of the items. We compared short forms developed using a random item selection process to short forms developed with consideration of the items relation to subdomains of fatigue (ie, physical and cognitive fatigue. Scores on short forms developed using content balancing more successfully predicted full item bank scores than did scores on short forms developed by random selection of items.Keywords: psychometrics, outcomes, quality of life, measurement, fatigue

  9. Characterization of Unruh channel in the context of open quantum systems

    Science.gov (United States)

    Banerjee, Subhashish; Kumar Alok, Ashutosh; Omkar, S.; Srikanth, R.

    2017-02-01

    In this work, we study an important facet of field theories in curved space-time, viz. the Unruh effect, by making use of ideas of statistical mechanics and quantum foundations. Aspects of decoherence and dissipation, natural artifacts of open quantum systems, along with foundational issues such as the trade-off between coherence and mixing as well as various aspects of quantum correlations are investigated in detail for the Unruh effect. We show how the Unruh effect can be quantified mathematically by the Choi matrix approach. We study how environmentally induced decoherence modifies the effect of the Unruh channel. The differing effects of a dissipative or non-dissipative environment are noted. Further, useful parameters characterizing channel performance such as gate and channel fidelity are applied here to the Unruh channel, both with and without external influences. Squeezing, which is known to play an important role in the context of particle creation, is shown to be a useful resource in a number of scenarios.

  10. Negative pressure pulmonary edema after nasal fracture reduction in an obese female patient: a case report

    Directory of Open Access Journals (Sweden)

    Choi EK

    2015-08-01

    Full Text Available Eunkyung Choi,1 Junggu Yi,1 Younghoon Jeon,2 1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea Abstract: Postoperative negative pressure pulmonary edema (NPPE is a rare, but well-known life-threatening complication of acute upper airway obstruction (UAO which develops after general anesthesia. The pronounced inspiratory efforts following UAO lead to excessive negative inspiratory pressure, which may cause acute pulmonary edema. Early recognition and prompt treatment of NPPE is necessary to prevent patient morbidity and mortality. In addition, the physician should carefully manage the patient who has risk factors of UAO to prevent this situation. We experienced a case of NPPE following laryngospasm after tracheal extubation in an obese patient who underwent open reduction of orbital wall and nasal bone surgery. Keywords: airway obstruction, negative pressure pulmonary edema, laryngospasm, nasal surgery, obese

  11. Sudden unilateral visual loss after autologous fat injection into the nasolabial fold

    Directory of Open Access Journals (Sweden)

    Sang Hyouk Park

    2008-10-01

    Full Text Available Sang Hyouk Park, Hae Jung Sun, Kyung Seek ChoiDepartment of ophthalmology, Soonchunhyang University College of Medicine, Seoul, KoreaAbstract: A 27-year-old female presented with sudden visual loss of her right eye after receiving an autologous fat injection into the right nasolabial fold. Fundus examination of the right eye showed multiple whitish patchy lesions with macular edema. Fluorescein angiogram showed deterioration of choroidal circulation with patchy choroidal filling and arm-to-retina circulation time and retinal arteriovenous passage time were delayed to 30 seconds and 20 seconds, respectively. There was no response in flash visual evoked potential (VEP. High dose steroid therapy (methylprednisolone 1 g/day/i.v. was done and about 2 weeks later, the disc edema subsided and retinal arteriovenous passage time of fluorescein angiogram was normalized but there was no improvement in visual acuity. Absence of a cherry red spot, deterioration of choroidal circulation with patchy choroidal fillings seen in fluorescein angiogram, and no response in flash VEP suggests multiple choroidal infarction due to perfusion defect of the short posterior ciliary artery. The autologous fat injected is thought to have entered the dorsal nasal artery and the retrograde migration of the emboli to the ophthalmic artery might have caused the multiple occlusions of the short posterior ciliary artery.Keywords: autologous fat injection, ciliary artery occlusion, ischemic optic neuropathy

  12. Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

    Directory of Open Access Journals (Sweden)

    Choi SJ

    2014-12-01

    Full Text Available Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction

  13. Comparison of clinical outcome after treatment of hip arthritis caused by MRSA with that caused by non-MRSA in infants.

    Science.gov (United States)

    Mortia, Mitsuaki; Nakamura, Hiroaki; Kitano, Toshio

    2009-01-01

    We compared the results of four patients treated for septic arthritis of the hip caused by methicillin-resistant Staphylococcus aureus (MRSA) with those of five non-MRSA cases. All four patients with MRSA were neonates when infection occurred, and all four had preceding sepsis and marked swelling of the thigh. The mean duration of follow-up was 5.6 years. At the time of most recent follow-up, all four exhibited severe discrepancy in leg length, and their femoral heads exhibited high-grade deformation according to the Choi classification. In contrast, in the non-MRSA cases, the mean age at infection was 2.2 years and the mean duration of follow-up was 2.9 years. At the most recent follow-up, they exhibited no remarkable discrepancy in leg length and only low-grade deformation of the femoral head. In this study, patients with MRSA showed more marked deformity of the hip and discrepancy of leg length because of lower age and to the presence of organisms resistant to antibiotics. Possible strategies for early diagnosis to prevent poor results after MRSA-induced hip arthritis include the following: (i) ensuring that pediatricians are familiar with the early signs of infection of the hip joint, (ii) aggressive puncture and drainage of pus from the affected joint, and (iii) initial use of antibiotics effective in treating MRSA, especially for patients suspected to have MRSA in the neonatal nursery.

  14. LPI Radar Waveform Recognition Based on Time-Frequency Distribution.

    Science.gov (United States)

    Zhang, Ming; Liu, Lutao; Diao, Ming

    2016-10-12

    In this paper, an automatic radar waveform recognition system in a high noise environment is proposed. Signal waveform recognition techniques are widely applied in the field of cognitive radio, spectrum management and radar applications, etc. We devise a system to classify the modulating signals widely used in low probability of intercept (LPI) radar detection systems. The radar signals are divided into eight types of classifications, including linear frequency modulation (LFM), BPSK (Barker code modulation), Costas codes and polyphase codes (comprising Frank, P1, P2, P3 and P4). The classifier is Elman neural network (ENN), and it is a supervised classification based on features extracted from the system. Through the techniques of image filtering, image opening operation, skeleton extraction, principal component analysis (PCA), image binarization algorithm and Pseudo-Zernike moments, etc., the features are extracted from the Choi-Williams time-frequency distribution (CWD) image of the received data. In order to reduce the redundant features and simplify calculation, the features selection algorithm based on mutual information between classes and features vectors are applied. The superiority of the proposed classification system is demonstrated by the simulations and analysis. Simulation results show that the overall ratio of successful recognition (RSR) is 94.7% at signal-to-noise ratio (SNR) of -2 dB.

  15. Electrostatic application of inert silica dust based insecticides onto plant surfaces.

    Science.gov (United States)

    Ulrichs, C; Krause, F; Rocksch, T; Goswami, A; Mewis, I

    2006-01-01

    One of the most effective naturally occurring insecticide powders is diatomaceous earth (DE), which contains above 96 % of silica (silicon dioxide SiO2). In recent days, the possibility to use new improved DE formulations for plant protection in horticulture has been the focus of research. For aphids and other under-leaf insects only insecticides deposited on leaf undersides are effective. We tested electrostatic application of different silica containing dusts onto the cruciferous crop pak-choi (Brassica chinensis). The materials tested were Fossil Shield 90.0s, Advasan, Biobeck PA910, and a formulation newly developed by the Urban Horticultural Section at Humboldt University called "Al-06". Silica materials were tested for their effect on plant photosynthesis and efficacy against the mustard beetle (Phaedon cochleariae F.). All materials have been effective in contact experiments against tested insects. However, significant differences were observed between materials after application onto plant leaves. Fossil Shield, Advasan, and Al-06 application resulted in a good coverage and in high protection against the mustard beetle. Biobeck PA910 was easily removed by wind from leaf surfaces and did not protect the plants well. However, photosynthesis has been reduced in treated plants and remained at a lower level even after dust removal. Experimental results are critically discussed in the view of future potential for crop protection programs.

  16. Prediction of fracture strength in Al2O3/SiCp ceramic matrix nanocomposites

    Directory of Open Access Journals (Sweden)

    Z. Zhang and D.L. Chen

    2007-01-01

    Full Text Available Based primarily on a recent publication [S.M. Choi, H. Awaji, Sci. Tech. Adv. Mater. 6 (2005 2–10.], where the dislocations around the nano-sized particles in the intra-granular type of ceramic matrix nanocomposites (CMNCs were modeled, dislocation activities in Al2O3/SiCp CMNCs were discussed in relation to the processing conditions. The dislocations around the nano-sized particles, caused by the thermal mismatch between the ceramic matrix and nano-sized particles, were assumed to hold out the effect of Orowan-like strengthening, although the conventional Owowan loops induced by the movement of dislocations were unlikely in the ceramic matrix at room temperature. A model involving the yield strength of metal matrix nanocomposites (MMNCs, where the Owowan strengthening effect was taken into consideration, was thus modified and extended to predict the fracture strength of the intra-granular type of CMNCs without and with annealing. On the basis of the characteristics of dislocations in the CMNCs, the load-bearing effect and Orowan-like strengthening were considered before annealing, while the load-bearing effect and enhanced dislocation density strengthening were taken into account after annealing. The model prediction was found to be in agreement with the experimental data of Al2O3/SiCp nanocomposites reported in the literature.

  17. Changes in Adenylate Nucleotides Concentration and Na+, K+-ATPase Activities in Erythrocytes of Horses in Function of Breed and Sex

    Directory of Open Access Journals (Sweden)

    Maria Suska

    2010-01-01

    Full Text Available The aim of this study was to examine the relationships between the concentrations of ATP, ADP, AMP (HPLC methods, total nucleotide pool (TAN, adenylate energy charge (AEC and Na+, K+-ATPase erythrocytic activities (by Choi's method of horses as a function of breed and sex. The studies were conducted on 54 horses (stallions and mares of different constitution types: breathing constitution (Wielkopolska and Hanoverian breed and digestive constitution (Ardenian breed. Horse erythrocytes, independently of examined breed, present low ATP concentration in comparison to other mammal species while retaining relatively high AEC. Erythrocytes of breathing constitution type horses appear to have a more intensive glucose metabolism and a more efficient energetic metabolism when compared to digestive constitution type horses. The conclusions may be proven by significantly higher ATP concentration, higher TAN and significantly higher AEC in breathing constitution type horses compared to the digestive constitution type. Sex does not significantly influence adenine nucleotides concentration in the erythrocytes of the examined horses, however, stallions have slightly higher values in comparison to mares. A positive correlation was found between Na+, K+, -ATPase activity, ATP, ADP and AMP concentration and TAN in Wielkopolska and Ardenian breeds, which was not confirmed for the Hanoverian breed.

  18. Expression of an Antisense BcMF3 Affects Microsporogenesis and Pollen Tube Growth in Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    LIU Le-cheng; CAO Jia-shu; YU Xiao-lin; XIANG Xun; FEI Yong-jun

    2006-01-01

    In an effort to provide some information relevant to the molecular mechanism of genic male sterility in plants, BcMF3 gene that encodes a pectin methylesterase was isolated from the fertile B line of Chinese cabbage-pak-choi (Brassica rapa ssp.chinensis, syn. B. campestris ssp. chinensis). In the present paper, a 455-bp antisense cDNA fragment of BcMF3 was introduced to binary vector pBI121, and then was mobilized into Agrobacterium tumefaciens strain LBA4404. The A.tumefaciens harboring the BcMF3 antisense fragment was transformed to Arabidopsis thaliana by floral dip. Scanning electronic microscopy examination demonstrated that 47.8% of BcMF3 antisense pollen grains exhibited abnormal shape,which might lead to decreased germination of pollens, suggesting that the product of BcMF3 gene plays an important role during microsporogenesis. The evidence on burst of 45.7% of BcMF3 antisense pollen tubes in vitro and a majority of BcMF3 antisense pollens restricted within the stigmatic tissue revealed that BcMF3 is involved in aiding the growth of pollen tubes. The results suggest that BcMF3 acts at both stages of microsporogensis and pollen tube growth.

  19. The Application of Time-Frequency Methods to HUMS

    Science.gov (United States)

    Pryor, Anna H.; Mosher, Marianne; Lewicki, David G.; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper reports the study of four time-frequency transforms applied to vibration signals and presents a new metric for comparing them for fault detection. The four methods to be described and compared are the Short Time Frequency Transform (STFT), the Choi-Williams Distribution (WV-CW), the Continuous Wavelet Transform (CWT) and the Discrete Wavelet Transform (DWT). Vibration data of bevel gear tooth fatigue cracks, under a variety of operating load levels, are analyzed using these methods. The new metric for automatic fault detection is developed and can be produced from any systematic numerical representation of the vibration signals. This new metric reveals indications of gear damage with all of the methods on this data set. Analysis with the CWT detects mechanical problems with the test rig not found with the other transforms. The WV-CW and CWT use considerably more resources than the STFT and the DWT. More testing of the new metric is needed to determine its value for automatic fault detection and to develop methods of setting the threshold for the metric.

  20. Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

    Directory of Open Access Journals (Sweden)

    Lee YK

    2014-12-01

    Full Text Available Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: Although the cytotoxicity of nanoparticles (NPs is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses. Keywords: nanostructured biomaterials, blood response, cytotoxicity, immunotoxicity, protein corona

  1. High-quality draft genome sequence of Gracilimonas tropica CL-CB462(T) (DSM 19535(T)), isolated from a Synechococcus culture.

    Science.gov (United States)

    Choi, Dong Han; Ahn, Chisang; Jang, Gwang Il; Lapidus, Alla; Han, James; Reddy, T B K; Huntemann, Marcel; Pati, Amrita; Ivanova, Natalia; Markowitz, Victor; Rohde, Manfred; Tindall, Brian; Göker, Markus; Woyke, Tanja; Klenk, Hans-Peter; Kyrpides, Nikos C; Cho, Byung Cheol

    2015-01-01

    Gracilimonas tropica Choi et al. 2009 is a member of order Sphingobacteriales, class Sphingobacteriia. Three species of the genus Gracilimonas have been isolated from marine seawater or a salt mine and showed extremely halotolerant and mesophilic features, although close relatives are extremely halophilic or thermophilic. The type strain of the type species of Gracilimonas, G. tropica DSM19535(T), was isolated from a Synechococcus culture which was established from the tropical sea-surface water of the Pacific Ocean. The genome of the strain DSM19535(T) was sequenced through the Genomic Encyclopedia of Type Strains, Phase I: the one thousand microbial genomes project. Here, we describe the genomic features of the strain. The 3,831,242 bp long draft genome consists of 48 contigs with 3373 protein-coding and 53 RNA genes. The strain seems to adapt to phosphate limitation and requires amino acids from external environment. In addition, genomic analyses and pasteurization experiment suggested that G. tropica DSM19535(T) did not form spore.

  2. Coherent tunneling of atoms from Bose-condensed gases at finite temperatures

    Science.gov (United States)

    Luxat, David L.; Griffin, Allan

    2002-04-01

    Tunneling of atoms between two trapped Bose-condensed gases at finite temperatures is explored using a many-body linear-response tunneling formalism similar to that used in superconductors. To lowest order, the tunneling currents can be expressed quite generally in terms of the single-particle Green's functions of isolated Bose gases. A coherent first-order tunneling Josephson current between two atomic Bose-Einstein condensates is found, in addition to coherent and dissipative contributions from second-order condensate-noncondensate and noncondensate-noncondensate tunneling. Our work is a generalization of Meier and Zwerger, who recently treated tunneling between uniform atomic Bose gases. We apply our formalism to the analysis of an out-coupling experiment induced by light wave fields, using a simple Bogoliubov-Popov quasiparticle approximation for the trapped Bose gas. For tunneling into the vacuum, we recover the results of Japha, Choi, Burnett, and Band, who recently pointed out the usefulness of studying the spectrum of out-coupled atoms. In particular, we show that the small tunneling current of noncondensate atoms from a trapped Bose gas has a broad spectrum of energies, with a characteristic structure associated with the Bogoliubov quasiparticle u2 and v2 amplitudes.

  3. Punding following posterior cerebral artery infarction: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Lin CI

    2017-03-01

    Full Text Available Cho-I Lin,1 Yu-Ching Lin,1–3 Wei-Chih Lien,1 Pei-Chun Hsieh,1 Sheng-Han Lin,1 Ta-Shen Kuan1,2 1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Physical Medicine and Rehabilitation, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan Introduction: Punding is a complex stereotyped behavior, characterized by excessiveness, non-goal orientation, and repetitiveness. It is mostly associated with Parkinson’s disease, and very few cases in non-Parkinson’s disease have been reported. We report a case of punding associated with supratentorial ischemic stroke.Case presentation: We present a 70-year-old man with left posterior cerebral artery infarction with quetiapine-induced punding manifesting as repetitive unidirectional body turning. Remission of punding behavior ensued after cessation of quetiapine and administration of clonazepam.Conclusion: This case describes the clinical course of quetiapine-induced punding in a patient with left posterior cerebral artery infarction. It suggests clonazepam may serve as a treatment option for poststroke punding. Keywords: punding, stereotyped behavior, stroke, quetiapine, clonazepam

  4. Quantum theory of the effect of grain boundaries on the electrical conductivity of thin films and wires

    Science.gov (United States)

    Moraga, Luis; Henriquez, Ricardo; Solis, Basilio

    2015-08-01

    We calculate the electrical conductivity of a metallic sample under the effects of distributed impurities and a random distribution of grain boundaries by means of a quantum mechanical procedure based on Kubo formula. Grain boundaries are represented either by a one-dimensional regular array of Dirac delta potentials (Mayadas and Shatzkes model) or by its three-dimensional extension (Szczyrbowski and Schmalzbauer model). We give formulas expressing the conductivity of bulk samples, thin films and thin wires of rectangular cross-sections in the case when the samples are bounded by perfectly flat surfaces. We find that, even in the absence of surface roughness, the conductivity in thin samples is reduced from its bulk value. If there are too many grain boundaries per unit length, or their scattering strength is high enough, there is a critical value Rc of the reflectivity R of an individual boundary such that the electrical conductivity vanishes for R >Rc. Also, the conductivity of thin wires shows a stepwise dependence on R. The effect of weak random variations in the strength or separation of the grain boundaries is computed by means of the method of correlation length. Finally, the resistivity of nanometric polycrystalline tungsten films reported in Choi et al. J. Appl. Phys. (2014) 115 104308 is tentatively analyzed by means of the present formalism.

  5. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS

    2016-12-01

    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  6. 147例弥漫大B细胞淋巴瘤患者的临床特点及预后分析%The clinical characteristics and prognostic analysis of 147 cases of diffuse large B-cell lymphoma

    Institute of Scientific and Technical Information of China (English)

    赵茜; 傅卫军; 张春阳; 杜鹃; 奚昊; 侯健

    2013-01-01

    -step Envision method of immunohistochemical staining was used to assess the expression of CD10,Bcl-6,MUM1,FOXP1,GCET1,CD5,Bcl-2,Ki-67,then according to Hans algorithm,Choi algorithm and Molecular markers,we compared the differences of their prognosies.Results ①)Kaplan-Meier univariate analysis of the clinical data of 147 DLBCL patients found that the 3-year overall survival (OS) rates were better in early stage (P=0.032),low IPI score (P=0.001),less than one extranodal involvement (P=0.014),and complete remission (P < 0.01).The prognosies had no significant differenced in terms of gender,age,LDH,B symptoms and treatment options (P value > 0.05).②For Hans model,GCB group had 42 cases,the ABC group 85 cases; GCB were 47 cases,ABC 80 cases (according to Choi model).Choi model suggested GCB subtype showed much better prognosis than ABC subtype (P=0.047),while Hans model shed no statistically significant difference (P=0.285).③Ki-67 of 75% was found to significantly discriminate patients with good or bad prognosis.In R-CHOP group at the same time,low Ki-67 (P=0.017) and CD5-negative groups (P=0.012) were better.Cox proportional hazards regression model showed that IPI score (P=0.002) and Ki-67 (P=0.019) were independent adverse prognostic factors.Conclusion The Ann Arbor stage,IPI score,extranodal involvement status and Ki-67 were significantly associated with prognosis.Compared to Hans algorithm,Choi had an advantage to predict the differente prognosis between subtypes,and ABC group had poor outcome.Finally,both Ki-67 and IPI score were independent adverse prognostic factors.

  7. PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

    Science.gov (United States)

    Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

    2010-04-01

    . The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

  8. Catálogo de sesgos o errores en cuestionarios sobre salud Catalog of bias in health questionnaires

    Directory of Open Access Journals (Sweden)

    Bernard Choi

    2010-12-01

    Full Text Available El cuestionario es ampliamente utilizado en el sector salud para recolectar información y se ha habido alguna discusión sobre la extensión y las fuentes de sesgos u errores que afectan la validez de la información obtenida, pero no hay una clara conciencia de la magnitud ni de la diversidad de los mismos. Se presentan y discuten los más resaltantes errores o sesgos en cuestionarios en el sector salud, basándonos en el trabajo previo de Choi y Pak. Objetivo: Este articulo intenta contribuirá a llevar al tapete de discusión el tema de los mecanismos y la dinámica de potenciales sesgos en cuestionarios del sector salud. Método: se realizó revisión de la literatura y se identificaron ejemplos extraídos de cuestionarios utilizados en diferentes proyectos, disponibles en forma impresa o en portales de Internet de acceso público. Resultados: Se identificaron 48 tipos diferentes de sesgo, se discute cada uno y se presentan formas de minimizarlos o evitarlos. Presenta una tabla resumen que se podría usar como tabla de cotejo, útil para prevenir y minimizar los potenciales sesgos. Discusión: el cuestionario es una herramienta común en diversas actividades del sector salud, no obstante se imparte poca capacitación formal sobre su uso en la mayoría de las especialidades del sector. Este artículo permite reducir la posibilidad de errores o sesgos que pueden invalidar la información, al presentar las posibilidades de error de una forma útil y accesible al usuario no experto en la materia.The questionnaire is extensively used on the health care sector to collect information, and there has been discussion on the magnitude, extension and sources of the bias that could compromise the validity of the information; however, awareness is limited on the magnitude and diversity of this topic. This article present the most relevant health sector questionnaire bias based upon a previous work by Choi and Pak. Objectives: These article intents to

  9. Preservação do inóculo de Plasmodiophora brassicae utilizando o método de congelamento Preservation of Plasmodiophora brassicae inoculum using the freezing method

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    Juliana Cristina Sodário Cruz

    2009-02-01

    Full Text Available A preservação das estruturas de resistência de Plasmodiophora brassicae, em condições laboratoriais, é dificultada pelo fato de se tratar de um parasita obrigatório. O método de congelamento, utilizando freezer, comum foi testado com o objetivo de viabilizar a sobrevivência e a preservação de suas características infectivas. Raízes de diferentes brássicas, naturalmente infectadas por P. brassicae, contendo sintomas típicos de hérnia, de uma mesma propriedade localizada no município de Pardinho, Estado de São Paulo, foram coletadas em diferentes épocas e imediatamente congeladas, em freezer, a aproximadamente -20ºC. Os tratamentos foram divididos da seguinte maneira: T1: hérnias congeladas por 389 dias (rúcula; T2: hérnias congeladas por 242 dias (brócolis; T3: hérnias congeladas por 21 dias (couve chinesa e T4: testemunha (sem inóculo. Os testes de patogenicidade, após diferentes períodos de armazenamento, foram realizados em condições de casa de vegetação (25±2ºC. Cada planta de uma variedade suscetível de couve-chinesa (Pak choi foi inoculada com 2mL da suspensão de esporos de cada tratamento, na concentração de 10(7 esporos.mL-1. Cada tratamento contou com seis repetições distribuídas em blocos ao acaso. Passadas cinco semanas após a inoculação, as raízes das plantas foram lavadas e avaliadas. Houve diferença significativa entre os tratamentos. Os materiais congelados, entre 21 a 242 dias preservaram suas características infectivas, mostrando que o método de congelamento em freezer, nesse período, pode ser uma boa opção para a preservação das estruturas de resistência deste patógeno.The preservation of Plasmodiophora brassicae resistance structures under laboratory conditions is difficult since this is an obligate parasite. The freezing method using an ordinary household freezer was tested to ensure the pathogen's survival and the preservation of its infective traits. Roots of different

  10. Morphodynamic equilibrium of alluvial estuaries

    Science.gov (United States)

    Tambroni, Nicoletta; Bolla Pittaluga, Michele; Canestrelli, Alberto; Lanzoni, Stefano; Seminara, Giovanni

    2014-05-01

    The evolution of the longitudinal bed profile of an estuary, with given plan-form configuration, subject to given tidal forcing at the mouth and prescribed values of water and sediment supply from the river is investigated numerically. Our main goal is to ascertain whether, starting from some initial condition, the bed evolution tends to reach a unique equilibrium configuration asymptotically in time. Also, we investigate the morphological response of an alluvial estuary to changes in the tidal range and hydrologic forcing (flow and sediment supply). Finally, the solution helps characterizing the transition between the fluvially dominated region and the tidally dominated region of the estuary. All these issues play an important role also in interpreting how the facies changes along the estuary, thus helping to make correct paleo-environmental and sequence-stratigraphic interpretations of sedimentary successions (Dalrymple and Choi, 2007). Results show that the model is able to describe a wide class of settings ranging from tidally dominated estuaries to fluvially dominated estuaries. In the latter case, the solution is found to compare satisfactory with the analytical asymptotic solution recently derived by Seminara et al. (2012), under the hypothesis of fairly 'small' tidal oscillations. Simulations indicate that the system always moves toward an equilibrium configuration in which the net sediment flux in a tidal cycle is constant throughout the estuary and equal to the constant sediment flux discharged from the river. For constant width, the bed equilibrium profile of the estuarine channel is characterized by two distinct regions: a steeper reach seaward, dominated by the tide, and a less steep upstream reach, dominated by the river and characterized by the undisturbed bed slope. Although the latter reach, at equilibrium, is not directly affected by the tidal wave, however starting from an initial uniform stream with the constant 'fluvial' slope, the final

  11. 基于MCC理论的内孤立波数值模拟%Numerical simulation for the internal solitary wave based on MCC theory

    Institute of Scientific and Technical Information of China (English)

    高原雪; 尤云祥; 王旭; 李巍

    2012-01-01

    Based on MCC (Miyata-Choi-Camassa) theory and fully nonlinear Euler equation for an ideal fluid, a CFD (computational fluid dynamics) numerical method is presented to simulate the generation and propagation of the internal solitary wave in a two-layer fluid, where the velocity-inlet boundary is applied by use of the depth-averaged velocities in the upper-and lower-layer fluids induced by the internal solitary wave. Based on a series of numerically simulated results, the relation between the design and numerically simulated amplitudes is obtained, and a numerical approach is proposed for simulating the internal solitary wave under the condition of giving its amplitude based on such a relation. Results show that the numerically simulated profile for the internal solitary wave has a good agreement with the MCC theory solution in the range of limited amplitudes, while both KdV ( Korteweg-de Vries) and mKdV ( modified KdV) theories are only suitable for the cases of small amplitudes. Moreover, the characteristics of the velocity fields induced by internal solitary waves are analyzed by use of CFD numerical results, which show that the horizontal velocities in both the upper-layer fluid and below the wave profile decay slowly, but such a horizontal velocity varies sharply in the fluid layer between the interface and wave profile due to the internal solitary wave.%基于MCC(Miyata-Choi-Camassa)理论,将内孤立波诱导上下层深度平均水平速度为入口条件,结合理想流体完全非线性欧拉方程,建立了两层流体中内孤立波生成与传播的CFD(Computational Fluid Dynamics)数值水槽方法.在系列数值模拟基础上,获得了内孤立波设计振幅与数值模拟振幅之间的相关关系,实现了在振幅可控条件下的内孤立波数值模拟.结果表明,在极限振幅范围内,数值模拟所得内孤立波波形均与MCC理论解吻合良好,而KdV (Korteweg-de Vries)和mKdV(modified KdV)理论解只适用于小振幅的情况

  12. Avaliação do tratamento da artrite séptica do quadril Treatment evaluation of septic arthritis of the hip

    Directory of Open Access Journals (Sweden)

    Anastácio Kotzias Neto

    2011-01-01

    Full Text Available Objetivo: Revisão dos resultados do tratamento de 46 crianças, 47 quadris, com artrite séptica do quadril e a investigação da relação entre os fatores prognósticos e os resultados clínicos obtidos. Métodos: Foram classificados, do ponto de vista clínico e radiográfico, de acordo com as classificações de Hunka e a de Choi, e distribuídos em grupos para estudo estatístico. O grupo 1 foi formado por pacientes classificados como tipo IA, e o grupo 2 pelos pacientes tipos IB ao IVB. A doença acometeu 30 meninos, sendo o lado direito comprometido em 26 crianças e uma delas com acometimento bilateral. A média de idade na apresentação foi de 50 meses, sendo maior no grupo 1 (p = 0,023. A cultura do líquido sinovial foi positiva em 23 pacientes e, dentre elas, em 18 cresceram Staphylococcus aureus. O tempo de sintomas até o tratamento cirúrgico teve média de 3,5 dias, sendo a espera no grupo 1 menor (p = 0,03. Resultados: Quarenta e seis pacientes, 47 quadris, que compareceram ao Ambulatório da Ortopedia do HIJG, e responderam ao protocolo, submetidos a exame físico e radiografias da bacia, além da revisão de dados do prontuário. O resultado do tratamento foi satisfatório na grande maioria dos casos. Conclusão: Pacientes jovens, que, na apresentação, não claudicavam, com cultura do líquido sinovial positiva para Staphylococcus aureus e demora na instituição do tratamento cirúrgico constituíram fatores de pior prognóstico nos resultados.Objective: Presenting a retrospective review of the results of treatment of children with septic arthritis of the hip and the investigation of the relationship between prognostic factors and the clinical results obtained. Methods: The patients evaluated (46 comprising 47 hips, who attended Orthopedics HIJG´s ambulatory clinic, answered a questionnaire, underwent physical examinations and radiographs of the pelvis, as well as the review of data from medical records. The patients

  13. Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic differentiation in human dental pulp stem cells

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    Park YJ

    2012-09-01

    Full Text Available Yoon Jung Choi,1,* Jue Yeon Lee,2,* Chong Pyoung Chung,2 Yoon Jeong Park,1,21Craniomaxillofacial Reconstructive Sciences, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; 2Research Institute, Nano Intelligent Biomedical Engineering, Seoul, Republic of Korea*These authors contributed equally to this workBackground: Human dental pulp stem cells (DPSCs have potential applications in tissue regeneration because of their convenient cell harvesting procedures and multipotent capacity. However, the tissue regenerative potential of DPSCs is known to be negatively regulated by aging in long-term culture and under oxidative stress. With an aim of reducing cellular senescence and oxidative stress in DPSCs, an intracellular delivery system for superoxide dismutase 1 (SOD1 was developed. We conjugated SOD1 with a cell-penetrating peptide known as low-molecular weight protamine (LMWP, and investigated the effect of LMWP-SOD1 conjugates on hydrogen peroxide-induced cellular senescence and osteoblastic differentiation.Results: LMWP-SOD1 significantly attenuated enlarged and flattened cell morphology and increased senescence-associated β-galactosidase activity. Under the same conditions, LMWP-SOD1 abolished activation of the cell cycle regulator proteins, p53 and p21Cip1, induced by hydrogen peroxide. In addition, LMWP-SOD1 reversed the inhibition of osteoblastic differentiation and downregulation of osteogenic gene markers induced by hydrogen peroxide. However, LMWP-SOD1 could not reverse the decrease in odontogenesis caused by hydrogen peroxide.Conclusion: Overall, cell-penetrating LMWP-SOD1 conjugates are effective for attenuation of cellular senescence and reversal of osteoblastic differentiation of DPSCs caused by oxidative stress inhibition. This result suggests potential application in the field of antiaging and tissue engineering to overcome the limitations of senescent stem cells.Keywords: superoxide

  14. A Theoretical Study of the Mechanism for the Photodecomposition of AgN3

    Institute of Scientific and Technical Information of China (English)

    SHI; Shou-heng

    2001-01-01

    [1]References Richard J. C. , J. Chem. Phys. , 64(8): 3 481(1976)[2]Guo, Guo-cong, Thomas C. W. M. , Angew. Chem. , 110(23), 3 460(1998)[3]Nicholls R. W. , J. Chem. Phys. , 64, 1 760(1960)[4]Evans B. L. , Proc. Roy. Soc. A. , 240, 484(1957)[5]Eggert J., Proc. Roy. Soc. A. , 246, 240(1957)[6]Boris V. L. , Thermochimixa Acta, 291, 179(1997)[7]Aduev B. P. , Aluker E. D. , Kriger V. G. , Solid Ionics, 101, 33(1997)[7]Meier U. ,Staemmler V. , J. Phys. Chem. , 95, 6 111(1991)[9]Schoennenbeck G. , Biehl H. , Stuhl F. , et al. , J. Chem. Phys. , 109(6), 2 210(1998)[10]Meier U. , Staemmler V. , Quantum Chemstry Programm Package of Ruhr University, Theror. Chim. Acta, 76(1989)[11]a. Marten R. L. , J. Phys. Chem. , 87, 750(1983); b. Huzinaga. J. Chem. Phys. , 42, 1 293(1965)[12]a. Huzinaga S., J. Chem. Phys. 42, 1 293(1965); b. Ahlrichs R. , Driessier F. , Lischka V. et al. , J. Chem.Phys. , 62, 1 235(1975)[13]Choi C. S. , Boutin H. P., Acta Crystallogr. Sect. B25, 982(1969)[14]Shouheng Shi, Staemmler V. , Phys. Rev. , 52(16), 12 345(1996)

  15. Targeted Acoustic Data Processing for Ocean Ecological Studies

    Science.gov (United States)

    Sidorovskaia, N.; Li, K.; Tiemann, C.; Ackleh, A. S.; Tang, T.; Ioup, G. E.; Ioup, J. W.

    2015-12-01

    The Gulf of Mexico is home to many species of deep diving marine mammals. In recent years several ecological studies have collected large volumes of Passive Acoustic Monitoring (PAM) data to investigate the effects of anthropogenic activities on protected and endangered marine mammal species. To utilize these data to their fullest potential for abundance estimates and habitat preference studies, automated detection and classification algorithms are needed to extract species acoustic encounters from a continuous stream of data. The species which phonate in overlapping frequency bands represent a particular challenge. This paper analyzes the performance of a newly developed automated detector for the classification of beaked whale clicks in the Northern Gulf of Mexico. Current used beaked whale classification algorithms rely heavily on experienced human operator involvement in manually associating potential events with a particular species of beaked whales. Our detection algorithm is two-stage: the detector is triggered when the species-representative phonation band energy exceeds the baseline detection threshold. Then multiple event attributes (temporal click duration, central frequency, frequency band, frequency sweep rate, Choi-Williams distribution shape indices) are measured. An attribute vector is then used to discriminate among different species of beaked whales present in the Gulf of Mexico and Risso's dolphins which were recognized to mask the detections of beaked whales in the case of widely used energy-band detectors. The detector is applied to the PAM data collected by the Littoral Acoustic Demonstration Center to estimate abundance trends of beaked whales in the vicinity of the 2010 oil spill before and after the disaster. This algorithm will allow automated processing with minimal operator involvement for new and archival PAM data. [The research is supported by a BP/GOMRI 2015-2017 consortium grant.

  16. Attack pattern of Platypus koryoensis (Coleoptera: Curculionidae: Platypodinae) in relation to crown dieback of Mongolian oak in Korea.

    Science.gov (United States)

    Lee, Jung-Su; Haack, Robert A; Choi, Won Il

    2011-12-01

    The ambrosia beetle, Platypus koryoensis (Murayama), vectors the Korean oak wilt (KOW) pathogen, Raffaelea quercus-mongolicae K.H. Kim, Y.J. Choi, & H.D. Shin, in Korea, which is highly lethal to Mongolian oak, Quercus mongolica Fisch., and is considered a major threat to forest ecosystem health. We characterized the attack pattern of P. koryoensis along the lower trunk of 240 Mongolian oaks in relation to tree decline symptoms on Mt. Uam in Gyeonggi-Do Province, Korea during June-July 2009. For each tree, we recorded diameter at breast height (dbh) (DBH) and P. koryoensis entrance hole density at two heights along the lower trunk (near groundline and at 1.5 m above groundline) and on opposite sides (downslope side and upslope side). Trees were assigned to one of three dieback classes: 1) apparently healthy, no or practically no wilted foliage, and no obvious platypodine frass near the base of the tree; 2) no or only partial wilting with obvious frass near the base of the tree; and 3) apparently recently killed by KOW with all foliage wilted and mostly retained with obvious frass near the base of the tree. As dieback class increased from 1 to 3, P. koryoensis entrance hole density increased at all four trunk locations. Attack density was highest on the downslope side of the trunk near groundline, and principal component analysis indicated that this trunk location was the best indicator of tree dieback. In addition, DBH tended to increase with dieback class suggesting that larger trees were infested first.

  17. Comparison of the current AJCC-TNM numeric-based with a new anatomical location-based lymph node staging system for gastric cancer: A western experience

    Science.gov (United States)

    Auricchio, Annamaria; Cardella, Francesca; Mabilia, Andrea; Diana, Anna; Castellano, Paolo; De Vita, Ferdinando; Orditura, Michele

    2017-01-01

    Background In gastric cancer, the current AJCC numeric-based lymph node staging does not provide information on the anatomical extent of the disease and lymphadenectomy. A new anatomical location-based node staging, proposed by Choi, has shown better prognostic performance, thus soliciting Western world validation. Study design Data from 284 gastric cancers undergoing radical surgery at the Second University of Naples from 2000 to 2014 were reviewed. The lymph nodes were reclassified into three groups (lesser and greater curvature, and extraperigastric nodes); presence of any metastatic lymph node in a given group was considered positive, prompting a new N and TNM stage classification. Receiver-operating-characteristic (ROC) curves for censored survival data and bootstrap methods were used to compare the capability of the two models to predict tumor recurrence. Results More than one third of node positive patients were reclassified into different N and TNM stages by the new system. Compared to the current staging system, the new classification significantly correlated with tumor recurrence rates and displayed improved indices of prognostic performance, such as the Bayesian information criterion and the Harrell C-index. Higher values at survival ROC analysis demonstrated a significantly better stratification of patients by the new system, mostly in the early phase of the follow-up, with a worse prognosis in more advanced new N stages, despite the same current N stage. Conclusions This study suggests that the anatomical location-based classification of lymph node metastasis may be an important tool for gastric cancer prognosis and should be considered for future revision of the TNM staging system. PMID:28380037

  18. Age peculiarities of reproductive morbidity in female participants of the ChNPP accident consequences clean up (according to the figures from SRU, 1988-2012 survey period).

    Science.gov (United States)

    Mayevska, I O; Buzunov, V O

    2015-12-01

    Meta: vyznachyty ta otsinyty osoblyvosti zakhvoriuvanosti statevoI systemy u zhinok uchasnyts' likvidatsiI naslidkiv avariI na ChAES 1986–1987 rr. zalezhno vid reproduktyvnogo viku na moment oprominennia ta chasu pislia opromi nennia.Materialy i metody. U statti predstavleno dani Derzhavnogo reiestru UkraIny osib, iaki postrazhdaly vnaslidok Chornobyl's'koI katastrofy. Provedeno analiz rivnia i struktury zakhvoriuvanosti statevoI systemy u 17237 zhinok uchasnyts' likvidatsiI naslidkiv avariI na ChAES 1986–1987 rr. zalezhno vid chasu perebuvannia pid ryzykom pislia oprominennia i reproduktyvnogo viku v moment oprominennia. Period monitoryngu 1988–2012 rr. Dlia vyz nachennia rivnia zakhvoriuvanosti, dovirchykh intervaliv i virogidnosti riznytsi vykorystano probnu versiiu programy OpenEpiversion 2.3.1., virogidnist' riznytsi vyznachalas' z vykorystanniam kryteriIv z score i t.Rezul'taty. Rezul'taty kogortnogo epidemiologichnogo doslidzhennia vyiavyly osoblyvosti rozvytku khvorob zhino choI statevoI systemy zalezhno vid reproduktyvnogo viku na moment oprominennia ta chasu perebuvannia pid ryzy kom pislia oprominennia. Provedeno porivnial'nyy statystychnyy analiz rivnia i struktury zakhvoriuvanosti state voI systemy za riznyy period chasu sposterezhennia.Vysnovok. Faktorom ryzyku zbil'shennia zakhvoriuvanosti na leyomiomy matky, dobroiakisni dysplaziI molochnoI zalozy, sal'pingooforyty mozhe buty oprominennia u reproduktyvnomu vitsi (18–45 r.). Mozhna prypustyty, shcho tkanyny matky ta molochnoI zalozy u zhinok, oprominenykh u reproduktyvnomu vitsi bil'sh chutlyvi na vplyv radiatsiynogo oprominennia, nizh u zhinok, iaki buly oprominenni u premenopauzi ta menopauzi.

  19. Measuring negative symptoms in patients with schizophrenia: reliability and validity of the Korean version of the Motivation and Pleasure Scale-Self-Report

    Directory of Open Access Journals (Sweden)

    Kim JS

    2016-05-01

    Full Text Available Ji-Sun Kim,1 Seon-Kyeong Jang,1 Seon-Cheol Park,2 Jung-Seo Yi,3 Joong-Kyu Park,4 Jung Suk Lee,5 Kee-Hong Choi,6 Seung-Hwan Lee1,7 1Clinical Emotion and Cognition Research Laboratory, Goyang, 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, 3Department of Psychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 4Department of Rehabilitation Psychology, Daegu University, Daegu, 5Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, 6Department of Psychology, Korea University, Seoul, 7Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea Background: The Clinical Assessment Interview for Negative Symptoms (CAINS is one of the validated interview measures of negative symptoms in psychotic disorders. The Motivation and Pleasure Scale-Self-Report (MPSR is a self-report measure that assesses the motivation and pleasure domains of negative symptoms based on the CAINS. This study evaluated the reliability and validity of a Korean version of the MPSR.Methods: A total of 139 patients with schizophrenia completed the MPSR, CAINS, Scale for the Assessment of Negative Symptoms (SANS, Brief Psychiatric Rating Scales, Calgary Depression Scale for Schizophrenia, and other measures of trait and cognitive function.Results: The 15-item MPSR showed good internal consistency. In addition, it also had a good convergent validity with the Motivation and Pleasure subscale of the CAINS and the anhedonia/avolition subscale of the SANS. The scale was not associated with psychotic symptoms, agitation/mania, and depression/anxiety, and it showed good discriminant validity. MPSR scores were significantly correlated with Behavioral Activation System total score for trait measure.Conclusion: The Korean version of the MPSR is a notable self-report method for examining the severity of negative symptoms in schizophrenia. Keywords: Korean

  20. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

    Directory of Open Access Journals (Sweden)

    Kim SR

    2015-08-01

    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

  1. Would Confucius benefit from psychotherapy? The compatibility of cognitive behaviour therapy and Chinese values.

    Science.gov (United States)

    Hodges, Julie; Oei, Tian P S

    2007-05-01

    The purpose of the present paper is to explore the conceptual compatibility between cognitive behaviour therapy (CBT) and the common values of Chinese Culture. In order to address such a question, the distinctive processes attributed to CBT (e.g., teaching of skills, emphasis on homework, cognitive processes, present/future focus), as summarized in the meta-analysis by Blagys and Hilsenroth [(2002). Distinctive activities of cognitive-behavioral therapy: A review of the comparative psychotherapy process literature. Clinical Psychology Review, 22, 671-706], and the core values of Chinese Culture, determined through an integration of The Hofstede Project, [Hofstede, G.H. (1980). Culture's consequences: International differences in work related values. Beverly Hills: Sage]. The Chinese Value Survey [Chinese Culture Connection (1987). Chinese values and the search for culture-free dimensions of culture. Journal of Cross-Cultural Psychology, 18, 143-164]. The Schwartz Value Survey [Schwartz, S.H. (1994). Cultural dimensions of values: Towards an understanding of national differences. In Kim, U., Trandis, H.C., Katiticibasi, C., Choi, S.C., & Yoon, G. (eds.), Individualism and collectivism: Theory, method and application (pp. 85-119). Thousand Oaks, CA: Sage] were used. A strong degree of compatibility between the two was found and it is argued that rather than developing new indigenized therapies, with some structural changes to the processes of CBT, this therapy can be effective for Chinese clients. It is further proposed that Chinese clients may benefit from challenging their irrational cognitions that are bound up in their strict adherence to social norms. Future recommendations for increasing the compatibility of CBT to Chinese culture are discussed.

  2. Enhanced detection of single-cell-secreted proteins using a fluorescent immunoassay on the protein-G-terminated glass substrate

    Directory of Open Access Journals (Sweden)

    Jeong Y

    2015-11-01

    Full Text Available Yoon Jeong,1,2 Kwan Hong Lee,1,2 Hansoo Park,3 Jonghoon Choi1,2 1Department of Bionano Technology, Graduate School, Hanyang University, Seoul, 2Department of Bionano Engineering, Hanyang University ERICA, Ansan, 3School of Integrative Engineering, Chung-Ang University, Seoul, South Korea Abstract: We present an evaluation of protein-G-terminated glass slides that may contain a suitable substrate for aligning the orientation of antibodies to obtain better binding moiety to the target antigen. The results of the protein-G-terminated slides were compared with those obtained with epoxy-based slides to evaluate signal enhancement for human immunoglobulin G (IgG targets, and an increase in the average fluorescence intensity was observed for the lowest measurable amount of IgG target in the assay using protein-G-terminated slides. Applying this strategy for signal amplification to single-cell assays improves the limits of detection for human IgG protein and cytokines (interleukin-2 and interferon-γ captured from hybridomas. Our data indicate that protein-G-terminated slides have a higher binding capacity for antigens and have better spot-to-spot consistency than that of traditional epoxy-based slides. These properties would be beneficial in the detection of fine amounts of single-cell-secreted proteins, which may provide key insights into cell–cell communication and immune responses. Keywords: microwell array, antibody’s orientation, single cell analysis, secreted cytokine, protein-G-terminated surface

  3. Preliminary development of the Active Colonoscopy Training Model

    Directory of Open Access Journals (Sweden)

    Choi J

    2011-06-01

    Full Text Available JungHun Choi1, Kale Ravindra1, Randolph Robert1, David Drozek21Mechanical Engineering, Ohio University, Athens, OH, USA; 2College of Osteopathic Medicine, Ohio University, Athens, OH, USAAbstract: Formal colonoscopy training requires a significant amount of time and effort. In particular, it requires actual patients for a realistic learning experience. The quality of colonoscopy training varies, and includes didactic courses and procedures proctored by skilled surgeons. A colonoscopy training model is occasionally used as part of the training method, but the effects are minute due to both the simple and tedious training procedures. To enhance the educational effect of the colonoscopy training model, the Active Colonoscopy Training Model (ACTM has been developed. ACTM is an interactive colonoscopy training device which can create the environment of a real colonoscopy procedure as closely as possible. It comprises a configurable rubber colon, a human torso, sensors, a display, and the control part. The ACTM provides audio and visual interaction to the trainee by monitoring important factors, such as forces caused by the distal tip and the shaft of the colonoscope and the pressure to open up the lumen and the localization of the distal tip. On the computer screen, the trainee can easily monitor the status of the colonoscopy, which includes the localization of the distal tip, maximum forces, pressure inside the colon, and surgery time. The forces between the rubber colon and the constraints inside the ACTM are measured and the real time display shows the results to the trainee. The pressure sensors will check the pressure at different parts of the colon. The real-time localized distal tip gives the colonoscopy trainee easier and more confident operation without introducing an additional device in the colonoscope. With the current need for colonoscopists and physicians, the ACTM can play an essential role resolving the problems of the current

  4. Reconstruction of the hip joint in children after septic coxitis

    Directory of Open Access Journals (Sweden)

    Михаил Павлович Тепленький

    2016-06-01

    Full Text Available Background.Surgical treatment of destructive dislocations is problematic, and controversial. Treatment options range from active monitoring to complex multistage reconstruction protocols.Materials and methods.The results of treatment of 17 children with disruptive dislocation of the hip (class IV according to the Choi classification are presented. The mean age at which treatment was started was 6.3 ± 0.5 years (range: 3-9 years. Treatment strategies included formation of the weight-bearing contact of the proximal femur and acetabulum and ilium osteotomy using an Ilizarov frame. The follow-up period lasted from 2 to 11 years. Clinical results were assessed using Colton’s criteria. Assessment of the radiology findings included the anatomy relations and congruence of the articular surfaces. The patients were divided into two groups, according to age, for data analysis.Results.The majority (88% of the children had positive anatomical and functional outcomes. The functional results were good (12-15 points, satisfactory (9-11 points, and unsatisfactory (8 points for 3, 5, and 1, respectively, among 3-6 year olds and 2, 6, and 0, respectively, among 7-9 year olds. The distribution of joint congruence types I, III, and IV was 2, 4, and 3, respectively, in the younger group and 1, 6, and 1, respectively, in the older group.Conclusion.The use of reconstructive surgery using the Ilizarov apparatus in children with a defect of the proximal femur creates conditions for the adaptation of incongruent articular components without causing decompensation of the joint.

  5. Acute Effect of High-Intensity Eccentric Exercise on Vascular Endothelial Function in Young Men.

    Science.gov (United States)

    Choi, Youngju; Akazawa, Nobuhiko; Zempo-Miyaki, Asako; Ra, Song-Gyu; Shiraki, Hitoshi; Ajisaka, Ryuichi; Maeda, Seiji

    2016-08-01

    Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.

  6. The Large-Grained Dust Coma of 174P/Echeclus

    Science.gov (United States)

    Bauer, James M.; Choi, Young-Jun; Weissman, Paul R.; Stansberry, John A.; Fernandez, Yanga R.; Roe, Henry G.; Buratti, Bonnie J.; Sung, Hyun-Il

    2008-01-01

    On 2005 December 30, Y.-J. Choi and P. R. Weissman discovered that the formerly dormant Centaur 2000 EC98 was in strong outburst. Previous observations by P. Rousselot et al. spanning a 3-year period indicated a lack of coma down to the 27 mag arcsec 2 level.We present Spitzer Space Telescope MIPS observations of this newly active Centaur--now known as 174P/Echeclus (2000 EC98)--or 60558 Echeclus--taken in 2006 late February. The images show strong signal at both the 24 and 70 micron bands and reveal an extended coma about 2' in diameter. Analyses yield estimates of the coma signal contribution that are in excess of 90% of the total signal in the 24 micron band. Dust production estimates ranging from 1.7-4 x 10(exp 2) kg/s are on the order of 30 times that seen in other Centaurs. Simultaneous visible-wavelength observations were also obtained with Palomar Observatory's 200-inch telescope, the 1.8-m Vatican Advanced Technology Telescope, the Bohyunsan Optical Astronomy Observatory (BOAO) 1.8-m telescope, and Table Mountain Observatory's 0.6-m telescope, revealing a coma morphology nearly identical to the mid-IR observations. The grain size distribution derived from the data yields a log particle mass power-law with slope parameter (alpha) = -0.87 +/- 0.07, and is consistent with steady cometary-activity, such as that observed during the Stardust spacecraft's encounter at 81P/Wild 2, and not with an impact driven event, such as that caused by the Deep Impact experiment.

  7. Supply chain coordination with buy back contract under risk constraints%风险约束下回购合同的供应链协调

    Institute of Scientific and Technical Information of China (English)

    程永文; 周永务

    2011-01-01

    报童问题是研究供应链协调的基本模型.可是,多数结果都是基于风险中性的假定.在现实世界中,理性决策者既寻求利润又关注风险.我们扩展了风险中性世界中供应链协调的概念,引入均值方差分析,探索不同风险约束下回购合同的协调问题.模型显示与集中供应链相比,分散供应链却具有分散风险的作用.另外,解决了蔡德铭等模型的局限性,即在给定批发价格下求解回购价格,而做到了同时决定批发价格和回购价格.%The newsvendor problem is a basic model in studying supply chain coordination.However, most of the results are grounded on the assumption of risk-neutral agents. Rational decision makers in the real world both seek profit and reduce risk. The conception of supply chain coordination in the risk-neutral world was extended, the mean-variance analysis was introduced and the newsvendor problem was explored, which involves the coordination by buyback contracts under different risk constraints. The model indicates that decentralized supply chain has the function of diversifying risk in comparison with centralized supply chain. In addition, we simultaneously get the solution about wholesale price and buyback price, thus extend Choi's model.

  8. Impact of GOLD groups of chronic pulmonary obstructive disease on surgical complications

    Directory of Open Access Journals (Sweden)

    Kim HJ

    2016-02-01

    Full Text Available Hyung-Jun Kim,1,2 Jinwoo Lee,1,2 Young Sik Park,1,2 Chang-Hoon Lee,1,2 Sang-Min Lee,1,2 Jae-Joon Yim,1,2 Chul-Gyu Yoo,1,2 Young Whan Kim,1,2 Sung Koo Han,1,2 Sun Mi Choi1,2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Purpose: Chronic obstructive pulmonary disease (COPD is associated with increased postoperative complications. Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD classified COPD patients into four groups based on spirometry results and the severity of symptoms. The objective of this study was to evaluate the impact of GOLD groups on postoperative complications. Patients and methods: We reviewed the medical records of COPD patients who underwent preoperative spirometry between April and August 2013 at a tertiary hospital in Korea. We divided the patients into GOLD groups according to the results of spirometry and self-administered questionnaires that assessed the symptom severity and exacerbation history. GOLD groups, demographic characteristics, and operative conditions were analyzed. Results: Among a total of 405 COPD patients, 70 (17.3% patients experienced various postoperative complications, including infection, wound, or pulmonary complications. Thoracic surgery, upper abdominal surgery, general anesthesia, large estimated blood loss during surgery, and longer anesthesia time were significant risk factors for postoperative complications. Patients in high-risk group (GOLD groups C or D had an increased risk of postoperative complications compared to those in low-risk group (GOLD groups A or B. Conclusion: COPD patients in GOLD groups representing a high exacerbation risk have an increased risk of postoperative complications compared to those with low risk. Keywords: chronic obstructive pulmonary

  9. Cryptanalysis and improvement of two multi-server remote user authentication schemes using smart cards%对两个基于智能卡的多服务器身份认证方案的密码学分析与改进

    Institute of Scientific and Technical Information of China (English)

    屈娟; 李艳平; 伍习丽

    2015-01-01

    身份认证是用户访问网络资源时的一个重要安全问题.近来,Xu等(xU C,JIA Z,WEN F,et al.Cryptanalysis and improvement of a dynamic ID based remote user authentication scheme using smart cards[J].Journal of Computational Information Systems,2013,9(14):5513-5520)提出了一个基于智能卡的动态身份用户认证方案.分析指出其方案不能抵抗中间人攻击和会话密钥泄露攻击,且无法实现会话密钥前向安全性.此外,指出Choi等(CHOI Y,NAM J,LEE D,et al.Security enhanced anonymous multiserver authenticated key agreement scheme using smart cards and biometrics[J].The Scientific World Journal,2014,2014:281305)提出的基于智能卡和生物特征的匿名多服务器身份认证方案(简称CNL方案)易遭受智能卡丢失攻击、服务器模仿攻击,且不能提保护用户的匿名性.最后,基于生物特征和扩展混沌映射,提出了一个安全的多服务器认证方案,安全分析结果表明,新方案消除了Xu方案和CNL方案的安全漏洞.

  10. SEARCH FOR ALTERNATIVE HOST SPECIES FOR MASS PRODUCTION SYSTEM OF Trichogramma ostriniae

    OpenAIRE

    Yoshiyasu, Yutaka; Hirai, Kazuo; Takeda, Makio; Cassanello, A.M.Lajarthe; Maramag, A.Z.; Yao, N-Zue

    2000-01-01

    アワノメイガの生物防除素材としてのTrichogramma ostriniaeの大量増殖のための代替寄主を探索した。鱗翅目5種、直翅目1種、ゴキブリ目1種、双翅目1種を調べた結果、発育速度、出てくるハチの大きさ、寄生率から判断してハチノスツヅリガが最適であるという結論に達した。このハチはコナガのような小さい卵も攻撃したが、湿気ある卵は攻撃しなかった。ゴキブリ、コオロギ、タマネギバエはこの理由で不適と判断された。サクサンは中国で大量飼育の材料に使われているが、近縁のヤママユガからは羽化する個体が得られなかった。 / Alternative host species were sought for mass production of Trichogramma ostriniae. Out of 5 lepidopterans, 1 orthopteran, 1 dictyopteran and 1 dipteran species that were examined, Galleria mellonella was found to be the material of choi...

  11. Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model

    Directory of Open Access Journals (Sweden)

    Choi G

    2016-01-01

    Full Text Available Goeun Choi,1 Huiyan Piao,1 Zeid A Alothman,2 Ajayan Vinu,3 Chae-Ok Yun,4 Jin-Ho Choy1 1Center for Intelligent Nano-Bio Materials, Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea; 2Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia; 4Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea Abstract: Methotrexate (MTX, an anticancer agent, was successfully intercalated into the anionic clay, layered double hydroxides to form a new nanohybrid drug. The coprecipitation and subsequent hydrothermal method were used to prepare chemically, structurally, and morphologically well-defined two-dimensional drug-clay nanohybrid. The resulting two-dimensional drug-clay nanohybrid showed excellent colloidal stability not only in deionized water but also in an electrolyte solution of Dulbecco’s Modified Eagle’s Medium with 10% fetal bovine serum, in which the average particle size in colloid and the polydispersity index were determined to be around 100 and 0.250 nm, respectively. The targeting property of the nanohybrid drug was confirmed by evaluating the tumor-to-blood and tumor-to-liver ratios of the MTX with anionic clay carrier, and these ratios were compared to those of free MTX in the C33A orthotopic cervical cancer model. The biodistribution studies indicated that the mice treated with the former showed 3.5-fold higher tumor-to-liver ratio and fivefold higher tumor-to-blood ratio of MTX than those treated with the latter at 30 minutes postinjection. Keywords: anionic clay, biodistribution, cervical cancer, colloidal stability, layered double hydroxide, methotrexate 

  12. In search of a theoretical structure for understanding motivation in schizophrenia.

    Science.gov (United States)

    Medalia, Alice; Brekke, John

    2010-09-01

    This themed issue considers different ways to conceptualize the motivational impairment that is a core negative symptom of schizophrenia. Motivational impairment has been linked to poor functional outcome, thus it is important to understand the nature and causes of motivational impairment in order to develop better treatment strategies to enhance motivation and engage patients in the process of recovery. Motivation refers to the processes whereby goal-directed activities are instigated and sustained and can be thought of as the product of a complex interaction of physiological processes and social contextual variables. In this issue, the physiological processes of motivation are the focus of Barch and Dowd, who highlight the role of prefrontal and subcortical mesolimbic dopamine systems in incentive-based learning and the difficulties people with schizophrenia have using internal representations of relevant experiences and goals to drive the behavior that should allow them to obtain desired outcomes. The articles in this issue by Choi et al., Nakagami et al., and Silverstein, focus on social contextual or environmental variables that can shape behavior and motivation. Together, these articles highlight the impact of external cues and goal properties on the expectations and values attached to goal outcomes. Expectancy-value and Self-Determination theories provide an overarching framework to accommodate the perspectives and data provided in all these articles. In the following introduction we show how the articles in this themed issue both support the role of expectancies and value in motivation in schizophrenia and elucidate possible deficiencies in the way expectations and value get assigned.

  13. Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

    Directory of Open Access Journals (Sweden)

    Ganesan P

    2017-02-01

    Full Text Available Palanivel Ganesan,1,2 Palanisamy Arulselvan,3 Dong-Kug Choi1,2 1Nanotechnology Research Center and Department of Applied Life Science, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea; 3Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Malaysia Abstract: Type 2 diabetes mellitus (T2DM is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes. Keywords: type 2 diabetes, nanodelivery system, phytobioactive compounds

  14. Diagnostic usefulness of lung SPET in pulmonary thromboembolism: an outcome study.

    Science.gov (United States)

    Corbus, H F; Seitz, J P; Larson, R K; Stobbe, D E; Wooten, W; Sayre, J W; Chavez, R D; Unguez, C E

    1997-10-01

    The lung single photon emission tomographic (SPET) images of 985 consecutive patients referred for suspected pulmonary embolism were correlated with clinical outcome and angiography to evaluate the clinical usefulness of lung SPET compared to conventional planar ventilation/perfusion lung imaging. SPET interpretations followed the revised PIOPED criteria and clinical outcome was determined from referring physicians, hospital records, direct patient contact and county hall records. Patients were deemed to have had no clinically significant pulmonary embolism at the time of the SPET examination if, within the following 3 months: (1) the patient was alive and had no clinical evidence of pulmonary embolism or, (2) if deceased, pulmonary embolism was unlikely to have been the cause of death. Operating characteristics were based on the methods of Choi and of Simel. SPET interpretation was categorized as follows: high probability, 143 (14%); low probability, 840 (82%); intermediate, 41 (4%) (in contrast to PIOPED, with 39% intermediate interpretations). Pulmonary angiography was performed in only 4% of patients. Adequate follow-up data were available for 97% of patients. To facilitate comparison with PIOPED, either a high-probability or an intermediate-probability or an intermediate-probability study was considered to be a positive test, and either a low-probability or a normal study was considered to be a negative test. The sensitivity was 83% (PIOPED 82%), specificity 92% (PIOPED 52%), positive predictive value 62% (PIOPED 47%) and negative predictive value 97% (PIOPED 85%). The positive and negative predictive values have not been corrected for prevalence, which was approximately twice as high in the PIOPED study. Lung SPET provided accurate diagnostic information in 96% of patients and specificity was greatly improved compared to planar lung imaging reported in PIOPED. The diminished need for angiography greatly reduced the cost of evaluating patients suspected of

  15. N-nitrosodimethylamine formation during treatment with strong oxidants of dimethylamine containing water.

    Science.gov (United States)

    Andrzejewski, P; Nawrocki, J

    2007-01-01

    The aim of the paper is the evaluation of the possibility of NDMA formation, as a result of strong oxidants reacting with DMA. Summarized results of investigations on N-nitrosodimethylamine formation as a result of dimethylamine reactions with chlorine dioxide, ozone and hydrogen peroxide are presented. Preliminary results of experiments on NDMA formation as a result of DMA reactions with permanganate are also shown. The experiments on dimethylamine reactions with chlorine dioxide, hydrogen peroxide and permanganate were carried out at room temperature under static conditions. Ozonation experiments were carried out at room temperature in a semi-continuous mode. Water samples from all experiments described above were collected during the experiment itself and subsequently analyzed with HPLC-IE with UV-Vis detector at 230 nm. NDMA formation was also confirmed by GC-LRMS. NDMA forms as a result of chlorine dioxide, ozone, hydrogen peroxide or permanganate reactions with dimethylamine. both in the presence as well as in the absence of ammonia ions. The presence of nitrites and nitrates in a post-reaction mixture suggests that NDMA are formed as the result of DMA reactions with nitrites. Thus the mechanism of NDMA formation with these oxidants is different than that described by Mitch et al. and Choi et al. The results also showed a conversion ratio of DMA to NDMA of even up to a single percent (with relation to amines), a simultaneous decrease of NDMA formation potential with a decrease of pH, however, in the case of chlorine dioxide application, a maximum conversion ratio was observed, as well the NDMA formation potential is strongly dependent on the oxidant/DMA ratio.

  16. Hong Kong: country profile.

    Science.gov (United States)

    Fozzard, A

    1988-09-01

    In the 1840s, the small fishing community that is now Hong Kong became a British colony and an important naval base for the Opium Wars. Now it is a leading capitalist center operating on mainland communist China. Hong Kong is scheduled to go back to China in 1997. In the agreement signed between the British government and China, Hong Kong's present lifestyle is guaranteed for at least 50 years. Textbook colonialism rules here. Foreigners hold the key jobs and earn much more than do the indigenous people. They even receive subsidized housing in this very high rent colony. As for the Hong Kong Chinese, overcrowding into 2 room apartments is the norm even though the government tries to provide more housing units. The large skyscrapers in the New Territories breed their unique social and mental health problems, such as poverty, drug abuse and frustration. Essentially all food is imported from communist China, yet agriculture in Hong Kong does exist--pig farms, duck lakes, and fields of the popular vegetable choi sum. Major industry comprise textiles and sweat shops which pay their workers (mostly illegal immigrants and children with no legal protection) wages that are 1/4 of those paid in Great Britain. Financial services, trade, and tourism may soon dominate Hong Kong's economy. Almost 4 million tourists visit Hong Kong yearly, often looking for bargains. Despite Hong Kong's active Western-like business climate, Chinese culture still abounds. Traditional incense burns in Buddhist temples. Snake soup is served in restaurants. Plus traditional medicine practiced alongside Western medicine contributes to Hong Kong having 1 of the lowest infant mortality rates in the world (9/1000) and to its high life expectancy of 76 years.

  17. CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies.

    Science.gov (United States)

    Wen, Wan-Shun; Yuan, Zhi-Min; Ma, Shi-Jie; Xu, Jiang; Yuan, Dong-Tang

    2016-03-15

    The RNA-guided nuclease CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR associated nuclease 9) and its variants such as nickase Cas9, dead Cas9, guide RNA scaffolds and RNA-targeting Cas9 are convenient and versatile platforms for site-specific genome editing and epigenome modulation. They are easy-to-use, simple-to-design and capable of targeting multiple loci simultaneously. Given that cancer develops from cumulative genetic and epigenetic alterations, CRISPR-Cas9 and its variants (hereafter referred to as CRISPR-Cas9 systems) hold extensive application potentials in cancer modeling and therapy. To date, they have already been applied to model oncogenic mutations in cell lines (e.g., Choi and Meyerson, Nat Commun 2014;5:3728) and in adult animals (e.g., Xue et al., Nature 2014;514:380-4), as well as to combat cancer by disabling oncogenic viruses (e.g., Hu et al., Biomed Res Int 2014;2014:612823) or by manipulating cancer genome (e.g., Liu et al., Nat Commun 2014;5:5393). Given the importance of epigenome and transcriptome in tumourigenesis, manipulation of cancer epigenome and transcriptome for cancer modeling and therapy is a promising area in the future. Whereas (epi)genetic modifications of cancer microenvironment with CRISPR-Cas9 systems for therapeutic purposes represent another promising area in cancer research. Herein, we introduce the functions and mechanisms of CRISPR-Cas9 systems in genome editing and epigenome modulation, retrospect their applications in cancer modelling and therapy, discuss limitations and possible solutions and propose future directions, in hope of providing concise and enlightening information for readers interested in this area.

  18. Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis

    Directory of Open Access Journals (Sweden)

    Lee HJ

    2014-12-01

    Full Text Available Hyo-Jeong Lee,1 Jakkid Sanetuntikul,2 Eun-Sook Choi,1 Bo Ram Lee,1 Jung-Hee Kim,1 Eunjoo Kim,1 Sangaraju Shanmugam2 1Nano and Bio Research Division, 2Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C particles using a single-component precursor, iron (III diethylenetriaminepentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light, the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm-2. These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. Keywords: graphitic carbon–encapsulated magnetic nanoparticles, iron oxide, one-pot synthesis, photothermal cancer therapy

  19. Bioreactor systems for tissue engineering II. Strategies for the expansion and directed differentiation of stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, Cornelia [Hannover Univ. (Germany). Inst. fuer Technische Chemie; Griensven, Martijn van [Ludwig Boltzmann Institut fuer Klinische und Experimentelle Traumatologie, Wien (Austria); Poertner, Ralf (eds.) [Technische Univ. Hamburg-Harburg (Germany). Inst. Biotechnologie und Verfahrenstechnik

    2010-07-01

    Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; - Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; - Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; - Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; - Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; - Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; - Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; - Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; - Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geissler, C. Gittel, H. Juelke, W. Brehm; - Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; - Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi. (orig.)

  20. Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

    Directory of Open Access Journals (Sweden)

    Choi SJ

    2015-04-01

    Full Text Available Soo-Jin Choi, Hee-Jeong Paek, Jin YuDepartment of Food Science and Technology, Seoul Women’s University, Seoul, Republic of KoreaAbstract: Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs that have been shown to exhibit toxicity by inducing reactive oxidative species and a proinflammatory mediator in human lung epithelial A549 cells. However, the molecular mechanism responsible for this LDH-NP-induced toxicity and the relationship between oxidative stress and inflammatory events remains unclear. In this study, we focused on intracellular signaling pathways and transcription factors induced in response to oxidative stress caused by exposure to LDH-NPs in A549 cells. Mitogen-activated protein kinase (MAPK cascades, such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase (JNK, and p38, were investigated as potential signaling mechanisms responsible for regulation of oxidative stress and cytokine release. Src family kinases (SFKs, which are known to mediate activation of MAPK, together with redox-sensitive transcription factors, including nuclear factor kappa B and nuclear factor-erythroid 2-related factor-2, were also investigated as downstream events of MAPK signaling. The results obtained suggest that LDH-NP exposure causes oxidative stress, leading to expression of antioxidant enzymes, such as catalase, glucose reductase, superoxide dismutase, and heme oxygenase-1, via a SFK-JNK and p38-nuclear factor kappa B signaling pathway. Further, activation of this signaling was also found to regulate release of inflammatory cytokines, including interleukin-6 and interleukin-8, demonstrating the inflammatory potential of LDH-NP.Keywords: layered double hydroxide, mitogen-activated protein kinases, Src family kinases, nuclear factor kappa B, oxidative stress, inflammatory cytokine

  1. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

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    Lee JH

    2016-08-01

    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  2. High-performance liquid chromatography-mass spectrometry analysis of plant metabolites in brassicaceae.

    Science.gov (United States)

    De Vos, Ric C H; Schipper, Bert; Hall, Robert D

    2012-01-01

    The Brassicaceae family comprises a variety of plant species that are of high economic importance as -vegetables or industrial crops. This includes crops such as Brassica rapa (turnip, Bok Choi), B. oleracea (cabbages, broccoli, cauliflower, etc.), and B. napus (oil seed rape), and also includes the famous genetic model of plant research, Arabidopsis thaliana (thale cress). Brassicaceae plants contain a large variety of interesting secondary metabolites, including glucosinolates, hydroxycinnamic acids, and flavonoids. These metabolites are also of particular importance due to their proposed positive effects on human health. Next to these well-known groups of phytochemicals, many more metabolites are of course also present in crude extracts prepared from Brassica and Arabidopsis plant material.High-pressure liquid chromatography coupled to mass spectrometry (HPLC-MS), especially if combined with a high mass resolution instrument such as a QTOF MS, is a powerful approach to separate, detect, and annotate metabolites present in crude aqueous-alcohol plant extracts. Using an essentially unbiased procedure that takes into account all metabolite mass signals from the raw data files, detailed information on the relative abundance of hundreds of both known and, as yet, unknown semipolar metabolites can be obtained. These comprehensive metabolomics data can then be used to, for instance, identify genetic markers regulating metabolic composition, determine effects of (a)biotic stress or specific growth conditions, or establish metabolite changes occurring upon food processing or storage.This chapter describes in detail a procedure for preparing crude extracts and performing comprehensive HPLC-QTOF MS-based profiling of semi-polar metabolites in Brassicaceae plant material. Compounds present in the extract can be (partially or completely) annotated based on their accurate mass, their MS/MS fragments and on other specific chemical characteristics such as retention time and UV

  3. Effects of Varying Epoch Lengths, Wear Time Algorithms, and Activity Cut-Points on Estimates of Child Sedentary Behavior and Physical Activity from Accelerometer Data.

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    Jorge A Banda

    Full Text Available To examine the effects of accelerometer epoch lengths, wear time (WT algorithms, and activity cut-points on estimates of WT, sedentary behavior (SB, and physical activity (PA.268 7-11 year-olds with BMI ≥ 85th percentile for age and sex wore accelerometers on their right hips for 4-7 days. Data were processed and analyzed at epoch lengths of 1-, 5-, 10-, 15-, 30-, and 60-seconds. For each epoch length, WT minutes/day was determined using three common WT algorithms, and minutes/day and percent time spent in SB, light (LPA, moderate (MPA, and vigorous (VPA PA were determined using five common activity cut-points. ANOVA tested differences in WT, SB, LPA, MPA, VPA, and MVPA when using the different epoch lengths, WT algorithms, and activity cut-points.WT minutes/day varied significantly by epoch length when using the NHANES WT algorithm (p < .0001, but did not vary significantly by epoch length when using the ≥ 20 minute consecutive zero or Choi WT algorithms. Minutes/day and percent time spent in SB, LPA, MPA, VPA, and MVPA varied significantly by epoch length for all sets of activity cut-points tested with all three WT algorithms (all p < .0001. Across all epoch lengths, minutes/day and percent time spent in SB, LPA, MPA, VPA, and MVPA also varied significantly across all sets of activity cut-points with all three WT algorithms (all p < .0001.The common practice of converting WT algorithms and activity cut-point definitions to match different epoch lengths may introduce significant errors. Estimates of SB and PA from studies that process and analyze data using different epoch lengths, WT algorithms, and/or activity cut-points are not comparable, potentially leading to very different results, interpretations, and conclusions, misleading research and public policy.

  4. A new model to estimate prognosis in patients with hepatocellular carcinoma after Yttrium-90 radioembolization.

    Directory of Open Access Journals (Sweden)

    Zhihong Weng

    Full Text Available AIMS: The current prognostic model to estimate the survival in hepatocellular carcinoma (HCC patients treated with transarterial hepatic selective internal radiotherapy (SIRT is not fully characterized. The aim of this study was to establish a new scoring model including assessment of both tumor responses and therapy-induced systemic changes in HCC patients to predict survival at an early time point post-SIRT. METHODS AND MATERIALS: Between 2008 and 2012, 149 HCC patients treated with SIRT were included into this study. CT images and biomarkers in blood tested at one month post-SIRT were analyzed and correlated with clinical outcome. Tumor responses were assessed by RECIST 1.1, mRECIST, and Choi criteria. Kaplan-Meier methods were used to estimate survival curves. Cox regression was used in uni- and multivariable survival analyses and in the establishment of a prognostic model. RESULTS: A multivariate proportional hazards model was created based on the tumor response, the number of tumor nodules, the score of the model for end stage liver disease (MELD, and the serum C-reactive protein levels which were independent predictors of survival in HCC patients at one month post-SIRT. This prognostic model accurately differentiated the outcome of patients with different risk scores in this cohort (P<0.001. The model also had the ability to assign a predicted survival probability for individual patients. CONCLUSIONS: A new model to predict survival of HCC patients mainly based on tumor responses and therapy-induced systemic changes provides reliable prognosis and accurately discriminates the survival at an early time point after SIRT in these patients.

  5. Nitric oxide-releasing poly(lactic-co-glycolic acid-polyethylenimine nanoparticles for prolonged nitric oxide release, antibacterial efficacy, and in vivo wound healing activity

    Directory of Open Access Journals (Sweden)

    Nurhasni H

    2015-04-01

    Full Text Available Hasan Nurhasni,1 Jiafu Cao,1 Moonjeong Choi,1 Il Kim,2 Bok Luel Lee,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, South Korea; 2Department of Polymer Science and Engineering, Pusan National University, Busan, South KoreaAbstract: Nitric oxide (NO-releasing nanoparticles (NPs have emerged as a wound healing enhancer and a novel antibacterial agent that can circumvent antibiotic resistance. However, the NO release from NPs over extended periods of time is still inadequate for clinical application. In this study, we developed NO-releasing poly(lactic-co-glycolic acid-polyethylenimine (PEI NPs (NO/PPNPs composed of poly(lactic-co-glycolic acid and PEI/diazeniumdiolate (PEI/NONOate for prolonged NO release, antibacterial efficacy, and wound healing activity. Successful preparation of PEI/NONOate was confirmed by proton nuclear magnetic resonance, Fourier transform infrared spectroscopy, and ultraviolet/visible spectrophotometry. NO/PPNPs were characterized by particle size, surface charge, and NO loading. The NO/PPNPs showed a prolonged NO release profile over 6 days without any burst release. The NO/PPNPs exhibited potent bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA and Pseudomonas aeruginosa concentration-dependently and showed the ability to bind on the surface of the bacteria. We also found that the NO released from the NO/PPNPs mediates bactericidal efficacy and is not toxic to healthy fibroblast cells. Furthermore, NO/PPNPs accelerated wound healing and epithelialization in a mouse model of a MRSA-infected wound. Therefore, our results suggest that the NO/PPNPs presented in this study could be a suitable approach for treating wounds and various skin infections.Keywords: nitric oxide-releasing nanoparticles, PLGA, PEI, antimicrobial, wound healing

  6. Jupiter's Global Winds in Advance of the Juno Encounters

    Science.gov (United States)

    Wong, Michael H.; Tollefson, Joshua; Simon, Amy A.; Cosentino, Rick; de Pater, Imke; Marcus, Philip; Orton, Glenn S.; Morales-Juberias, Raul; Johnson, Perianne

    2016-10-01

    We use Hubble/WFC3 imaging observations in February 2016 to derive Jupiter's global wind field, the closest wind velocity measurement to Juno's focused atmospheric campaign (November 2016 through January 2017).Using the methods of Asay-Davis et al. (2011, Icarus 211, 1215), we derive zonal wind profiles from Outer Planet Atmospheres Legacy (OPAL) program data in 2015 and 2016, and from 2009 and 2012 data, all taken at red optical wavelengths with the WFC3/UVIS instrument. Several jets show significant variability in peakspeed over the 2000-2016 time period, while most jets are very stable.We quantify uncertainties in order to determine which changes are significant, and we find a roughly 2x improvement in precision compared to the HST/WFPC2 and Cassini-derived zonal wind profiles in Asay-Davis et al. (2011). Some improvement in precision is likely to be instrumental. The WFC3/UVIS detector better samples the HST point-spread function by about 15% compared to WFPC2, and the larger WFC3/UVIS field of view reduces navigational uncertainty by capturing the entire planetary disk in every image. It is not yet clear whether instrumental effects can explain the entire reduction in uncertainty, which could potentially include time-variable noise due to coherent features (waves, vortices) as well as turbulence. Global variability of this magnitude would be a surprise, since Asay-Davis et al. (2011) found the same level of velocity uncertainty (~11 m/s) in both Cassini data from 2000 and HST/WFPC2 data from 2008.We will generate spatial spectra of kinetic energy and cloud features (in multiple filters), using Fourier transforms of OPAL Jupier imaging data and 2D velocity fields. We will fit composite linear models (Barrado-Izagirre et al. 2009, Icarus 202, 181; Choi and Showman 2011, Icarus 216, 597) to the kinetic energy and cloud albedo spectra, comparing spectral indices to past observations and determining forcing scales.

  7. Cisplatin-incorporated nanoparticles of poly(acrylic acid-co-methyl methacrylate copolymer

    Directory of Open Access Journals (Sweden)

    Lee KD

    2013-08-01

    Full Text Available Kyung Dong Lee,1,* Young-Il Jeong,2,* Da Hye Kim,3,4 Gyun-Taek Lim,2 Ki-Choon Choi5 1Department of Oriental Medicine Materials, Dongshin University, Naju, South Korea; 2Department of Polymer Engineering, Chonnam National University, Gwangju, South Korea; 3Faculty of Life and Environmental Science, Shimane University, Matsue, Japan; 4United Graduate School of Agricultural Sciences, Tottori University, Tottori, Japan; 5Grassland and Forages Division, National Institute of Animal Science, Rural Development Administration, Cheonan, South Korea *These authors contributed equally to this work Background: Although cisplatin is extensively used in the clinical field, its intrinsic toxicity limits its clinical use. We investigated nanoparticle formations of poly(acrylic acid-co-methyl methacrylate (PAA-MMA incorporating cisplatin and their antitumor activity in vitro and in vivo. Methods: Cisplatin-incorporated nanoparticles were prepared through the ion-complex formation between acrylic acid and cisplatin. The anticancer activity of cisplatin-incorporated nanoparticles was assessed with CT26 colorectal carcinoma cells. Results: Cisplatin-incorporated nanoparticles have small particle sizes of less than 200 nm with spherical shapes. Drug content was increased according to the increase of the feeding amount of cisplatin and acrylic acid content in the copolymer. The higher acrylic acid content in the copolymer induced increase of particle size and decrease of zeta potential. Cisplatin-incorporated nanoparticles showed a similar growth-inhibitory effect against CT26 tumor cells in vitro. However, cisplatin-incorporated nanoparticles showed improved antitumor activity against an animal tumor xenograft model. Conclusion: We suggest that PAA-MMA nanoparticles incorporating cisplatin are promising carriers for an antitumor drug-delivery system. Keywords: cisplatin, nanoparticle, poly(acrylic acid-co-methyl methacrylate, ion complexes

  8. Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

    Directory of Open Access Journals (Sweden)

    Ganesan P

    2015-10-01

    Full Text Available Palanivel Ganesan,1,2 Hyun-Myung Ko,2 In-Su Kim,2 Dong-Kug Choi1,2 1Nanotechnology Research Center, Department of Applied Life Science, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea Abstract: Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD, which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1 the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2 the role of nanotechnology in reducing oxidative stress during PD; 3 nanodelivery systems; and 4 various nanophytobioactive compounds and their role in PD. Keywords: Parkinson’s disease, phytobioactive compounds, nanotechnology delivery systems, nanocurcumin

  9. Characterization and experimental validation of a squeeze film damper with MR fluid in a rotor-bearing system

    Science.gov (United States)

    Dominguez-Nuñez, L. A.; Silva-Navarro, G.

    2014-04-01

    The general study and applications of Magneto-Rhelogical (MR) dampers have been spread in the lasts years but only some studies have been focusing on the vibration control problems on rotor-bearings systems. Squeeze-Film Dampers (SFD) are now commonly used to passively control the vibration response on rotor-bearing systems because they can provide flexibility, damping and extend the so-called stability thresholds in rotating machinery. More recently, SFD are combined with MR or Electro-Rheological (ER) fluids to introduce a semiactive control mechanism to modify the rotordynamic coefficients and deal with the robust performance of the overall system response for higher operating speeds. There are, however, some theoretical and technological problems that complicate their extensive use, like the relationship between the centering spring flexibility and the rheological behavior of the smart fluid to produce the SFD forces. In this work it is considered a SFD with MR fluid and a set of circular section beams in a squirrel cage arrangement in combination with latex seals as centering springs. The mathematical model analysis includes the controllable viscoelastic properties associated to the MR fluid. The characterization of the SFD is made by the determination of some coefficients associated with a modified Choi-Lee-Park polynomial model. During the analysis is considered a rotor-bearing system modeled using finite element methods. The SFD with MR fluid is connected to an experimental platform to validate and experimentally evaluate the overall system. Finally, to improve the open-loop system performance, a methodology for the use of different control schemes is proposed.

  10. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

    Directory of Open Access Journals (Sweden)

    Ganesan P

    2016-05-01

    Full Text Available Palanivel Ganesan,1,2 Dong-Kug Choi1,2 1Department of Applied Life Science, Nanotechnology Research Center, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea Abstract: Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy. Keywords: nanodelivery technologies, skincare

  11. Changes in cerebral blood flow after cognitive behavior therapy in patients with panic disorder: a SPECT study

    Directory of Open Access Journals (Sweden)

    Seo HJ

    2014-04-01

    Full Text Available Ho-Jun Seo,1 Young Hee Choi,2 Yong-An Chung,3 Wangku Rho,1 Jeong-Ho Chae11Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Metta Institute of Cognitive Behavior Therapy, Seoul, South Korea; 3Department of Radiology, Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, South KoreaAim: Inconsistent results continue to be reported in studies that examine the neural correlates of cognitive behavioral therapy (CBT in patients with panic disorder. We examined the changes in regional cerebral blood flow (rCBF associated with the alleviation of anxiety by CBT in panic patients.Methods: The change in rCBF and clinical symptoms before and after CBT were assessed using single photon emission computed tomography and various clinical measures were analyzed.Results: Fourteen subjects who completed CBT showed significant improvements in symptoms on clinical measures, including the Panic and Agoraphobic Scale and the Anxiety Sensitivity Index-Revised. After CBT, increased rCBF was detected in the left postcentral gyrus (BA 43, left precentral gyrus (BA 4, and left inferior frontal gyrus (BA 9 and BA 47, whereas decreased rCBF was detected in the left pons. Correlation analysis of the association between the changes in rCBF and changes in each clinical measure did not show significant results.Conclusion: We found changes in the rCBF associated with the successful completion of CBT. The present findings may help clarify the effects of CBT on changes in brain activity in panic disorder.Keyword: single photon emission computed tomography (SPECT, anxiety, neural correlate, brain activity

  12. Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways

    Directory of Open Access Journals (Sweden)

    Choi YH

    2014-10-01

    Full Text Available Yung Hyun Choi,1,2 Gi-Young Kim,3 Hye Hyeon Lee4 1Department of Biochemistry, Dongeui University College of Korean Medicine, Busan, 2Anti-Aging Research Center and Blue-Bio Industry RIC, Dongeui University, Busan, 3Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju, 4Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: Cordycepin is the main functional component of the Cordyceps species, which has been widely used in traditional Oriental medicine. This compound possesses many pharmacological properties, such as an ability to enhance immune function, as well as antioxidant, antiaging, and anticancer effects. In the present study, we investigated the anti-inflammatory effects of cordycepin using a murine macrophage RAW 264.7 cell model. Our data demonstrated that cordycepin suppressed production of proinflammatory mediators such as nitric oxide (NO and prostaglandin E2 by inhibiting inducible NO synthase and cyclooxygenase-2 gene expression. Cordycepin also inhibited the release of proinflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1-beta, through downregulation of respective mRNA expression. In addition, pretreatment with cordycepin significantly inhibited lipopolysaccharide (LPS-induced phosphorylation of mitogen-activating protein kinases and attenuated nuclear translocation of NF-κB by LPS, which was associated with abrogation of inhibitor kappa B-alpha degradation. Furthermore, cordycepin potently inhibited the binding of LPS to macrophages and LPS-induced Toll-like receptor 4 and myeloid differentiation factor 88 expression. Taken together, the results suggest that the inhibitory effects of cordycepin on LPS-stimulated inflammatory responses in RAW 264.7 macrophages are associated with suppression of mitogen-activating protein kinases and activation of NF-κB by inhibition of the Toll-like receptor 4 signaling pathway. Keywords

  13. EFFECT OF TOPDRESSING WITH DIGESTED PIG SLURRY ON AMMONIA VOLATILIZATION IN VEGETABLE FIELDS%追施猪粪沼液对菜地氨挥发的影响

    Institute of Scientific and Technical Information of China (English)

    靳红梅; 常志州; 郭德杰; 吴华山

    2012-01-01

    氨挥发是肥料氮素损失的主要途径之一.以厌氧发酵后的猪粪沼液为研究对象,通过蔬菜大棚小区试验,分析其作为追肥表施于冬季菜地(水芹(Oenanthe clecumbens L.)和扬花萝卜(Raphanus sativus L.Var.Radiculus pets.);追施氮量分别为72 kg hm-2和54 kg hm-2)及夏季菜地(小白菜(Brassica chinensis L.)和大叶茼蒿(Chrysanthemum carinatum Schousb.);追施氮量分别为42 kg hm-2和63 kg hm-2)后的氨排放特征及其影响因子.研究结果表明:(1)施用猪粪沼液后菜地氨挥发激增,沼液中氮素以氨挥发形态损失较快,通常发生在施入后48 h内;(2)冬季芹菜地和萝卜地施用沼液后的累积氨排放量分别为8.68 kghm-2和9.90 kg hm-2,显著高于化肥处理(4.06 kg hm-2和5.59 kg hm-2);而夏季白菜地和茼蒿地则分别为10.40kg hm-2和11.61 kg hm-2,与化肥处理间差异不显著(9.81 kg hm-2和10.09 kg hm-2);(3)冬季菜地施用沼液后氨挥发损失率分别达到11.7%和17.7%,显著低于夏季菜地(23.3%和26.8%);(4)0 ~10 cm土层土壤温度、水分含量、可溶性有机碳含量、氮素水平及形态、微生物生物量及活性,均与菜地氨挥发有较高的关联度.沼液作为追肥施入农田后会因其自身氨挥发和激发效应而使氨排放增加,在施用过程中应特别注意温度的影响,同时应选择合适的施用方式.%Ammonia ( NH3) volatilization is a major pathway for gaseous nitrogen loss from fields applied with manure. To explore effects of topdressing of bio-digested manure slurry on ammonia volatilization, a field experiment was carried out in a vegetable greenhouse, applying bio-digested pig manure slurry ( DPS) on winter vegetable, cress ( Oenanthe clecumbens L. ) and radish ( Raphanus sativus L. Var. Radiculus pers. ) , and summer vegetable, pak choi ( Brassica chinensis L. ) and crown daisy ( Chrysanthemum carinatum Schousb. ). The topdressing rates of nitrogen were 72 kg hm ~ , 54 kg

  14. Guidelines for Authors

    Directory of Open Access Journals (Sweden)

    Abdullah Demir

    2016-06-01

    . As’ad Abukhalil, “Maronites,” in Encyclopedia of the Modern Middle East and North Africa, ed. Philip Mattar, 2nd ed., vol. 3 (New York: Macmillan Reference, 2004, 1491-92.2. Abukhalil, “Maronites,” 1492.Bibliography: Abukhalil, As’ad. “Maronites.” In Encycloedia or the Modern Middle East and North Africa. Edited by Philip Mattar. 2nd ed. Vol. 3. New York: Macmillan Reference, 1491-92.    DISSERTATIONFor theses and dissertations, the following order should be followed: name of the author and surname, full title of thesis in italics, thesis type, the name of the university and date.1. Mihwa Choi, “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty” (PhD diss., University of Chicago, 2008, 55.2. Choi, “Contesting Imaginaires,” 59. Bibliography: Choi, Mihwa. “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty.” PhD diss., University of Chicago, 2008. Chicago-Style Citation Quick Guide:http://www.chicagomanualofstyle.org/tools_citationguide.html 

  15. Cumhuriyet İlahiyat Dergisi Akademik Yazım Kılavuzu /Cumhuriyet Theology Journal Guidelines for Authors

    Directory of Open Access Journals (Sweden)

    Abdullah

    2016-12-01

    February 28, 2010. doi:10.1086/599247. ENCYCLOPEDIA ENTRIES For encylopedia entries, the author’s name and surname are written first. These are followed by the title of the entry in quotation marks, the full name of the encyclopedia, , the place and date of publication, its volume number and page numbers: 1. As’ad Abukhalil, “Maronites,” in Encyclopedia of the Modern Middle East and North Africa, ed. Philip Mattar, 2nd ed., vol. 3 (New York: Macmillan Reference, 2004, 1491-92. 2. Abukhalil, “Maronites,” 1492. Bibliography: Abukhalil, As’ad. “Maronites.” In Encycloedia or the Modern Middle East and North Africa. Edited by Philip Mattar. 2nd ed. Vol. 3. New York: Macmillan Reference, 1491-92. DISSERTATION For theses and dissertations, the following order should be followed: name of the author and surname, full title of thesis in italics, thesis type, the name of the university and date. 1. Mihwa Choi, “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty” (PhD diss., University of Chicago, 2008, 55. 2. Choi, “Contesting Imaginaires,” 59. Bibliography: Choi, Mihwa. “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty.” PhD diss., University of Chicago, 2008.

  16. PSEN1 L226F mutation in a patient with early-onset Alzheimer’s disease in Korea

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    Bagyinszky E

    2016-10-01

    Full Text Available Eva Bagyinszky,1,* Sun Ah Park,2,* Hyung Jun Kim,2 Seong Hye Choi,3 Seong Soo A An,1 SangYun Kim4 1Department of BioNano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Inha University School of Medicine, Incheon, 4Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: In this study, we report a first 226leucine (Leu mutation to phenylalanine (Phe in (PSEN1, CTC>TTC, L226F in Asia from a Korean early-onset Alzheimer’s disease (EOAD patient. Polymerase chain reaction (PCR–single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age, but the mutation seemed to be de novo, since no affected family member was found. This leucine to phenylalanine substitution may cause additional stresses inside the transmembrane region due to large aromatic side chain and increased hydrophobic interactions with hydrocarbon chains in the membrane and its binding partners. Clinical phenotype of the mutation was aggressive progression into neurodegeneration, resulting in rapid cognitive decline. One of the patients was initially diagnosed with frontotemporal dementia, but the diagnosis was revised to AD upon postmortem studies in which Aβ plaques were seen. A second mutation, L226R, was found for the L226 residue. Similar to L226F, the patient with L226R also developed the first symptoms in his 30s, but EOAD was diagnosed in his 40s. These findings suggested that L226 might be an important residue in PSEN1

  17. Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

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    Yousaf AM

    2016-01-01

    Full Text Available Abid Mehmood Yousaf,1,2 Omer Mustapha,1 Dong Wuk Kim,1 Dong Shik Kim,1 Kyeong Soo Kim,1 Sung Giu Jin,1 Chul Soon Yong,3 Yu Seok Youn,4 Yu-Kyoung Oh,5 Jong Oh Kim,3 Han-Gon Choi1 1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi, South Korea; 2Faculty of Pharmacy, University of Central Punjab, Johar, Lahore, Pakistan; 3College of Pharmacy, Yeungnam University, Gyongsan, North Gyeongsang, 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, 5College of Pharmacy, Seoul National University, Seoul, South Korea Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1

  18. Comparative study on solid self-nanoemulsifying drug delivery and solid dispersion system for enhanced solubility and bioavailability of ezetimibe

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    Rashid R

    2015-09-01

    Full Text Available Rehmana Rashid,1 Dong Wuk Kim,1 Abid Mehmood Yousaf,1 Omer Mustapha,1 Fakhar ud Din,1 Jong Hyuck Park,1 Chul Soon Yong,2 Yu-Kyoung Oh,3 Yu Seok Youn,4 Jong Oh Kim,2 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, South Korea; 2College of Pharmacy, Yeungnam University, Gyeongsan, South Korea; 3College of Pharmacy, Seoul National University, Seoul, South Korea; 4School of Pharmacy, Sungkyunkwan University, Suwon, South KoreaBackground: The objective of this study was to compare the physicochemical characteristics, solubility, dissolution, and oral bioavailability of an ezetimibe-loaded solid self-nanoemulsifying drug delivery system (SNEDDS, surface modified solid dispersion (SMSD, and solvent evaporated solid dispersion (SESD to identify the best drug delivery system with the highest oral bioavailability.Methods: For the liquid SNEDDS formulation, Capryol 90, Cremophor EL, and Tween 80 were selected as the oil, surfactant, and cosurfactant, respectively. The nanoemulsion-forming region was sketched using a pseudoternary phase diagram on the basis of reduced emulsion size. The optimized liquid SNEDDS was converted to solid SNEDDS by spray drying with silicon dioxide. Furthermore, SMSDs were prepared using the spray drying technique with various amounts of hydroxypropylcellulose and Tween 80, optimized on the basis of their drug solubility. The SESD formulation was prepared with the same composition of optimized SMSD. The aqueous solubility, dissolution, physicochemical properties, and pharmacokinetics of all of the formulations were investigated and compared with the drug powder.Results: The drug existed in the crystalline form in SMSD, but was changed into an amorphous form in SNEDDS and SESD, giving particle sizes of approximately 24, 6, and 11 µm, respectively. All of these formulations significantly improved the aqueous solubility and dissolution in the order of solid

  19. Elderly women who received Helicobacter pylori-eradicating therapy have reduced risk of low skeletal muscle mass

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    Baeg MK

    2015-10-01

    Full Text Available Myong Ki Baeg, Myung-Gyu Choi, Sun-Hye Ko, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Young-Seok Cho, Bo-In Lee, In-Seok LeeDepartment of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Republic of KoreaBackground: Sarcopenia is associated with adverse outcomes such as physical disability, poorer quality of life, and death. Helicobacter pylori (HP eradication increases ghrelin secretion, which may be a possible treatment for sarcopenia. We investigated whether HP eradication reduces the risk of low muscle mass (LMM, which is an integral component of sarcopenia.Materials and methods: Healthy, asymptomatic women aged ≥60 years who participated in a health screening program were enrolled. Subjects with a history of HP eradication were compared with those who were HP IgG+, but had not received HP-eradicating therapy. Body composition was measured by multifrequency bioelectrical impedance analysis. LMM was defined as body muscle mass 2 standard deviations below the mean muscle mass of healthy women aged 20–39 years from the same program. Multivariable analysis was used to identify sarcopenia risk factors.Results: Three hundred seventy-two women had received HP eradication, while 689 HP IgG+ women had not. The prevalence of LMM was significantly lower in those who received HP eradication (13.7% vs 21.6%, P=0.002. Multivariable analysis identified risk factors for LMM as age, white blood cell count, serum total protein concentration, and the metabolic syndrome. HP eradication (odds ratio: 0.632, 95% confidence interval: 0.440–0.824, P=0.013 was a significant preventive factor, and exercise (odds ratio: 0.710, 95% confidence interval: 0.504–1.002, P=0.051 had a preventive tendency.Conclusion: HP eradication might reduce LMM risk. This finding should be confirmed in prospective longitudinal studies to determine the long-term effects of HP eradication on sarcopenia.Keywords: sarcopenia, Helicobacter

  20. Electrophysiological recording of the brain, visualization, prediction, and interconnectivity

    Science.gov (United States)

    Talakoub, Omid

    The human brain is a complex network of interconnected neurons. The aim of neuroscience and neuroengineering is to decode the neural activity, visualize it and try to better understand how neurons communicate with each other. This dissertation comprises four contributions to the area. These four topics are discussing how functional relationship between brain activity and movement can be found and whether common features found in different regions are correlated (phase-locked). First, the method of chirplet decomposition offers a new way to visualize the time-frequency content of non-stationary signals with higher resolution than previously possible. The use of Wigner-Ville distribution together with chirplet decomposition allows a clearer visualization in terms of both the temporal and frequency details with detail higher than previously achieved using other methods including Choi-Williams and spectrogram. Second, an improved method of averaging of neural signals over repeated trials is introduced whereby slight variations in the alignment of the neural signal over time is corrected through the use of nonlinear shifts. In earlier studies, time alignment has been performed using linear shift (e.g. alignment with movement onset), but this process alone is not sufficient when the signal timing changes differently over time. To overcome this issue, nonlinear transformations were found to remove any temporal variabilities in the way the task was performed. Third, a multilinear model is demonstrated showing how limb velocity in a reach task can be predicted from neuroelectrical activity. The model, after fitting, suggested that high frequency oscillations have sufficient information for both detection of movement onset and reconstruction of its movement. The use of a linear model reduces the overall computational requirements and simplifies the reconstruction of movement kinematics. Finally, a fourth method involving the measurement of coherence over time reveals how

  1. PEGylated apoptotic protein-loaded PLGA microspheres for cancer therapy

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    Byeon HJ

    2015-01-01

    Full Text Available Hyeong Jun Byeon,1 Insoo Kim,1 Ji Su Choi,1 Eun Seong Lee,2 Beom Soo Shin,3 Yu Seok Youn11Department of Pharmaceutical Sciences, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea; 2Division of Biotechnology, The Catholic University of Korea, Bucheon-si, Republic of Korea; 3Department of Pharmacy, College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Republic of KoreaAbstract: The aim of the current study was to investigate the antitumor potential of poly(D,L-lactic-co-glycolic acid microspheres (PLGA MSs containing polyethylene glycol (PEG-conjugated (PEGylated tumor necrosis factor–related apoptosis-inducing ligand (PEG-TRAIL. PEG-TRAIL PLGA MSs were prepared by using a water-in-oil-in-water double-emulsion method, and the apoptotic activities of supernatants released from the PLGA MSs at days 1, 3, and 7 were examined. The antitumor effect caused by PEG-TRAIL PLGA MSs was evaluated in pancreatic Mia Paca-2 cell-xenografted mice. PEG-TRAIL PLGA MS was found to be spherical and 14.4±1.06 µm in size, and its encapsulation efficiency was significantly greater than that of TRAIL MS (85.7%±4.1% vs 43.3%±10.9%, respectively. The PLGA MS gradually released PEG-TRAIL for 14 days, and the released PEG-TRAIL was shown to have clear apoptotic activity in Mia Paca-2 cells, whereas TRAIL released after 1 day had a negligible activity. Finally, PEG-TRAIL PLGA MS displayed remarkably greater antitumor efficacy than blank or TRAIL PLGA MS in Mia Paca-2 cell-xenografted mice in terms of tumor volume and weight, apparently due to increased stability and well-retained apoptotic activity of PEG-TRAIL in PLGA MS. We believe that this PLGA MS system, combined with PEG-TRAIL, should be considered a promising candidate for treating pancreatic cancer.Keywords: Poly(D,L-lactic-co-glycolic acid, controlled release, PEGylation, TRAIL, pancreatic cancer

  2. Neurogenic effects of fingolimod in hippocampus, affecting fear memory.

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    Paschalis Efstathopoulos

    2014-05-01

    Full Text Available Fingolimod (FTY720; Gilenya™,Novartis Pharma AG is a recently developed Sphingosine-1-Phosphate (S1P analogue, orally administered as a new therapeutic agent in Multiple Sclerosis (MS (Brinkmann V. et al. 2010. S1P receptors (S1PRs are expressed in various sites in the CNS including the subventricular zone (Waeber C. et al. 1999; Choi J.W. et al. 2013 while endogenous S1P was shown to induce proliferation and morphological changes in embryonic hippocampal neural progenitors in culture (Harada J. et al. 2004. In this study we investigated the effects of fingolimod on adult rodent hippocampal neurogenesis and their possible functional role. To this aim, thymidine analogue BrdU was injected at the end or before a 2-week i.p. administration of a therapeutic dose of Fingolimod (0,3 mg/kg in young and old mice. Stereological counts of BrdU+ cells revealed significant increase in both proliferation, and survival of neural stem cells (NSC in the area of Dentate Gyrus (DG of the hippocampus, compared to control untreated animals of young but not old ages. In the case of survival assessment, most of the BrdU + cells were also positive for NeuN, suggesting an increase of newly formed neurons. The increase in proliferation rate of NSC was also confirmed by BrdU uptake in hippocampal NSC cultures in vitro, implying that the effects of fingolimod are cell autonomous. Immunohistochemical analysis showed that S1PR was not co-localized with GFAP+ cells in the Subgranular zone (SGZ of the DG, but was strongly co-localized with transcription factor MASH1 and weakly with DcX or PSA-NCAM positive neural progenitors. These findings suggest that expression of S1PR1 in the SGZ is restricted to transit amplifying neural progenitors and maintained also in the stage of neuroblast. In addition, the effects of Fingolimod in DG neurogenesis were positively correlated to enhanced fear memory and increased context discrimination, an established DG-dependent cognitive task

  3. Dynamic Wetting of CaO-Al2O3-SiO2-MgO Liquid Oxide on MgAl2O4 Spinel

    Science.gov (United States)

    Abdeyazdan, Hamed; Dogan, Neslihan; Rhamdhani, M. Akbar; Chapman, Michael W.; Monaghan, Brian J.

    2015-02-01

    Inclusion type and content in steel is critical in steelmaking, affecting both productivity through clogging, and downstream physical properties of the steel. They are normally removed from steel by reacting with a slag (liquid oxide) phase. For efficient inclusion removal, the inclusions must attach/bond with this liquid phase. The strength of the attachment can be in part characterized by the wettability of the liquid oxide on the inclusions. In this study, the dynamic wetting of liquid oxides of the CaO-Al2O3-SiO2-MgO system on a solid spinel (MgAl2O4) substrate with low porosity of 1.9 pct was measured at 1773 K (1500 °C) using a modified sessile drop technique. The dynamic contact angle between the liquid and solid spinel was determined for different CaO/Al2O3 mass percent ratios ranging from 0.98 to 1.55. Characteristic curves of wettability ( θ) vs time showed a rapid decrease in wetting in the first 10 seconds tending to a plateau value at extended times. A mathematical model for spreading behavior of liquid oxides by Choi and Lee was adopted and shown to provide a reasonable representation of the spreading behavior with time. The chemical interaction at the interface between spinel (MgAl2O4) and slag was analyzed by carrying out detailed thermodynamic evaluation and characterization using scanning electron microscopy/energy dispersive spectroscopy. There is evidence of liquid penetrating the substrate via pores and along grain boundaries, forming a penetration layer in the substrate. The depth of the penetration layer was found to be a function of substrate porosity and sample cooling rate. It decreased from ~350 µm for 6.7 pct-porous substrate to ~190 µm for substrate with porosity of 1.9 pct and from ~190 µm to ~50 µm for a slow-cooled liquid oxide-spinel substrate sample in the furnace to a rapidly cooled liquid cooled-spinel substrate sample, respectively.

  4. Development of paclitaxel-loaded liposomal nanocarrier stabilized by triglyceride incorporation

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    Hong SS

    2016-09-01

    Full Text Available Soon-Seok Hong,1 Ju Yeon Choi,2 Jong Oh Kim,2 Mi-Kyung Lee,3 So Hee Kim,4 Soo-Jeong Lim1 1Department of Bioscience and Bioengineering, Sejong University, Seoul, 2College of Pharmacy, Yeungnam University, Gyeongsan, 3College of Pharmacy, Woosuk University, Wanju-gun, Jeollabuk-do, 4College of Pharmacy and Research Institute of Pharmaceutical Science and Technology, Ajou University, Suwon, Republic of Korea Abstract: Studies have highlighted the challenge of developing injectable liposomes as a paclitaxel (PTX carrier, a challenge attributable to the limitations in liposomal stability caused by PTX loading. Poor stability of PTX-loaded liposomes is caused by PTX-triggered aggregation or fusion of liposomal membranes and is exacerbated in the presence of PEGylated lipid. In the present study, the effect of triglyceride incorporation on the stability of PTX-loaded/PEGylated liposomes was explored. Incorporation of a medium chain triglyceride Captex 300 into saturated phosphatidylcholine (PC-based liposomes (1,2-dimyristoyl-sn-glycero-3-phosphocholine [DMPC]:cholesterol [CHOL]:N-(Carbonyl-methoxypolyethyleneglycol 2000-1, 2-distearoyl-sn-glycero-3-phospho-ethanolamine [PE-PEG], produced a fine, homogeneous, and membrane-filterable PTX-loaded liposomes fulfilling the requirement of an injectable lipid formulation. Triglyceride incorporation also greatly inhibited the time-dependent leakage of PTX from saturated PC-based liposomes, which appears to be mediated by the inhibition of liposome fusion. In contrast, triglyceride incorporation induced the destabilization and PTX leakage of unsaturated PC-based liposomes, indicating the opposite effect of triglyceride depending on the fluidity status of PC constituting the liposomal membrane. PTX release profile and the in vitro and in vivo anticancer efficacy of triglyceride-incorporated DMPC:CHOL:PE-PEG liposomes were similar to Taxol® while the toxicity of liposomal PTX was significantly lower than that of

  5. An investigation of coseismic OSL / TL time zeroing of quartz gouge based on low- to high-velocity friction experiments

    Science.gov (United States)

    Akasegawa, K.; Oohashi, K.; Hasebe, N.; Miura, K.

    2016-12-01

    . References Okumura, T., and Shitaoka, Y., 2011. Engineering Geology of Japan, No. 1, 5-17. Hiraga, S., Yoshimoto, A., and Shimamoto, T., 2004. Bull. Nara Univ. Educ., Vol. 53, No. 2, 17-29. Ikeya, M., Miki, T. and Tanaka, K. 1982. Seience, 215, 1392-1393. Kim, J. H., Choi, J. H., Chauhan, N., Lee, S., Hirose, T., and Ree, J. H, 2014. AGU, Fall Meeting 2014.

  6. Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis

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    Suh JS

    2014-03-01

    Full Text Available Jin Sook Suh,1,* Jue Yeon Lee,2,* Yoon Jung Choi,1 Hyung Keun You,3 Seong-Doo Hong,4 Chong Pyoung Chung,2 Yoon Jeong Park1,2 1Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 2Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC, Seoul, 3Department of Periodontology, College of Dentistry, Wonkwang University, Iksan, 4Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Protein-transduction technology has been attempted to deliver macromolecular materials, including protein, nucleic acids, and polymeric drugs, for either diagnosis or therapeutic purposes. Herein, fusion protein composed of an arginine-rich cell-penetrating peptide, termed low-molecular-weight protamine (LMWP, and a transcriptional coactivator with a PDZ-binding motif (TAZ protein was prepared and applied in combination with biomaterials to increase bone-forming capacity. TAZ has been recently identified as a specific osteogenic stimulating transcriptional coactivator in human mesenchymal stem cell (hMSC differentiation, while simultaneously blocking adipogenic differentiation. However, TAZ by itself cannot penetrate the cells, and thus needs a transfection tool for translocalization. The LMWP-TAZ fusion proteins were efficiently translocalized into the cytosol of hMSCs. The hMSCs treated with cell-penetrating LMWP-TAZ exhibited increased expression of osteoblastic genes and protein, producing significantly higher quantities of mineralized matrix compared to free TAZ. In contrast, adipogenic differentiation of the hMSCs was blocked by treatment of LMWP-TAZ fusion protein, as reflected by reduced marker-protein expression, adipocyte fatty acid-binding protein 2, and peroxisome proliferator-activated receptor-γ messenger ribonucleic acid levels. LMWP-TAZ was applied in

  7. Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery

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    Song KH

    2015-03-01

    Full Text Available Keon-Hyoung Song,1 Sang-Bum Kim,2 Chang-Koo Shim,2 Suk-Jae Chung,2 Dae-Duk Kim,2 Sang-Ki Rhee,1 Guang J Choi,1 Chul-Hyun Kim,3 Kiyoung Kim4 1Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, Republic of Korea; 2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea; 3Department of Sports Medicine, 4Department of Medical Biotechnology, Soonchunhyang University, Asan, Republic of Korea Background: The identification of permeation enhancers has gained interest in the development of drug delivery systems. A six-mer peptide, H-FCIGRL-OH (AT1002, is a tight junction modulator with promising permeation-enhancing activity. AT1002 enhances the transport of molecular weight markers or agents with low bioavailability with no cytotoxicity. However, AT1002 is not stable in neutral pH or after incubation under physiological conditions, which is necessary to fully uncover its permeation-enhancing effect. Thus, we increased the stability or mitigated the instability of AT1002 by modifying its terminal amino acids and evaluated its subsequent biological activity.Methods: C-terminal-amidated (FCIGRL-NH2, Pep1 and N-terminal-acetylated (Ac-FCIGRL, Pep2 peptides were analyzed by liquid chromatography–mass spectrometry. We further assessed cytotoxicity on cell monolayers, as well as the permeation-enhancing activity following nasal administration of the paracellular marker mannitol.Results: Pep1 was nontoxic to cell monolayers and showed a relatively low decrease in peak area compared to AT1002. In addition, administration of mannitol with Pep1 resulted in significant increases in the area under the plasma concentration–time curve and peak plasma concentration at 3.63-fold and 2.68-fold, respectively, compared to mannitol alone. In contrast, no increase in mannitol concentration was shown with mannitol/AT1002 or mannitol/Pep2 compared to the control. Thus, Pep1 increased

  8. Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome

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    Yang YM

    2015-09-01

    Full Text Available Young-Mo Yang, Eun Joo Choi College of Pharmacy, Chosun University, Gwangju, South Korea Background: Polycystic ovary syndrome (PCOS is an endocrinopathy that affects approximately 10% of reproductive-aged women throughout their lives. Women with PCOS present with heterogeneous symptoms including ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. Therefore, lifelong individualized management should be considered. Pharmacological agents commonly used to manage the symptoms are metformin and oral contraceptive pills. Although these medications have been beneficial in treating PCOS symptoms, their efficacy and safety are still not entirely elucidated. This study aimed to report the efficacy and safety of metformin, oral contraceptives, or their combination in the treatment of PCOS and to define their specific individual roles.Methods: A literature search of original studies published in PubMed and Scopus was conducted to identify studies comparing metformin with oral contraceptives or evaluating the combination of both in PCOS.  Results: Eight clinical trials involving 313 patients were examined in the review. The intervention dosage of metformin ranged from 1,000 to 2,000 mg/d and that of oral contraceptives was ethinylestradiol 35 µg and cyproterone acetate 2 mg. Lower body mass index was observed with regimens including metformin, but increased body mass index was observed in monotherapy with oral contraceptives. Administration of metformin or oral contraceptives, especially as monotherapy, had a negative effect on lipid profiles. In addition, there are still uncertainties surrounding the effects of metformin or oral contraceptives in the management of insulin level, although they improved total testosterone and sex hormone-binding globulin levels. In the included studies, significant side effects due to metformin or oral contraceptives were not reported.  Conclusion: The clinical trials suggest that metformin or oral

  9. Charge sensing and real-time electron counting in quantum dots

    Science.gov (United States)

    Ihn, Thomas

    2012-02-01

    The charge state of a Coulomb blockaded quantum dot can be sensed at the single-electron level using charge sensors integrated on-chip [1]. Quantum point contacts or quantum dots have proven to work as reliable charge sensors. Coupling between the quantum dot's charge state and the sensor is provided by Coulomb interactions between electrons in the two systems. The technique is therefore independent of the material of quantum dot and sensor, and works for diverse systems such as GaAs [1] and graphene [2]. Different materials, such as InAs and GaAs have even been combined. Time-resolved charge sensing is of fundamental interest for studying the statistical properties of charge flow, like the full counting statistics. Single-shot charge and spin read-out schemes are also needed for the measurement of qubits. Some of our recent work has focused on the exploration and optimization of the read-out bandwidth limits. Towards this goal, we learned how to influence the dot-detector coupling [3], and how to employ high-frequency techniques in the range of a few hundred megahertz [4], or even up to a few gigahertz for improved performance. New experiments using the slower conventional sensing schemes have allowed us to explore non-equilibrium statistics and the fluctuation theorem. In our measurements, rare events can be detected, where electrons flow against the applied source-drain bias direction thereby consuming entropy in agreement with theoretical predictions. [4pt] [1] T. Ihn, S. Gustavsson, U. Gasser, R. Leturcq, I. Shorubalko, and K. Ensslin, Physica E: Low-dimensional Systems and Nanostructures 42, 803-808 (2010).[0pt] [2] J. G"uttinger, J. Seif, C. Stampfer, A. Capelli, K. Ensslin, and T. Ihn, Phys. Rev. B 83, 165445 (2011).[0pt] [3] C. R"ossler, B. K"ung, S. Dr"oscher, T. Choi, T. Ihn, K. Ensslin, and M. Beck, Appl. Phys. Lett. 97, 152109 (2010).[0pt] [4] T. M"uller, B. K"ung, S. Hellm"uller, P. Studerus, K. Ensslin, T. Ihn, M. Reinwald, and W. Wegscheider, Appl

  10. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

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    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, Yangsan, South KoreaAbstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs for the treatment of colitis. Eudragit FS30D was used as a pH-dependent polymer, and Eudragit RS100 as a time-dependent controlled release polymer. Single pH-dependent NPs (pH_NPs, single time-dependent NPs (Time_NPs, and dual pH/time-dependent NPs (pH/Time_NPs were prepared using the oil-in-water emulsion method. The physicochemical properties and drug release profiles of these NPs in gastrointestinal (GI tract conditions were investigated. The therapeutic potential and in vivo distribution of the NPs were evaluated in a dextran sulfate sodium (DSS-induced colitis mice model. The pH/Time_NPs prevented a burst drug release in acidic pH conditions and showed sustained release at a colonic pH. The in vivo distribution study in the mice GI tract demonstrated that pH/Time_NPs were more efficiently delivered to the inflamed colon than pH_NPs were. Compared to the single pH_NPs-treated group, the pH/Time_NPs-treated group showed increased body weight and colon length and markedly decreased disease activity index, colon weight/length ratios, histological damage, and inflammatory cell infiltration in colon tissue. Our results demonstrate that the dual pH/time-dependent NPs are an effective oral colon-targeted delivery system for colitis therapy.Keywords: colon-specific delivery, dual-sensitive delivery

  11. Efficacy and safety of tamsulosin hydrochloride 0.2 mg and combination of tamsulosin hydrochloride 0.2 mg plus solifenacin succinate 5 mg after transurethral resection of the prostate: a prospective, randomized controlled trial

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    Shin YS

    2016-09-01

    Full Text Available Yu Seob Shin,1,* Li Tao Zhang,1,* Jae Hyung You,1 In Sung Choi,1 Chen Zhao,2 Jong Kwan Park1 1Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Medical Device Clinical Trial Center of Chonbuk National University, Jeonju, Republic of Korea; 2Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Andrology, Shanghai, People’s Republic of China *These authors contributed equally to this work Objective: The objective of this study was to evaluate the safety and efficacy of tamsulosin hydrochloride 0.2 mg (TAM and its combination with solifenacin succinate 5 mg (SOL after transurethral resection of the prostate (TURP.Patients and methods: The patients were randomized into three groups: TURP (group 1, TURP plus TAM (group 2, and TURP plus TAM + SOL (group 3. Patients in group 2 and group 3 received medication for 4 weeks. The primary efficacy end points were the mean change in total International Prostate Symptom Score (IPSS and IPSS subscores. The secondary end points included quality-of-life score, Overactive Bladder Symptom Score, and short-form voiding and storage score of International Continence Society.Results: In total, 37 men (31.8% in group 1, 37 men (31.8% in group 2, and 42 men (36.2% in group 3 completed the study. In total IPSS, no significant improvement was seen from baseline to the end of treatment in groups 2 and 3 compared with group 1. However, in group 2, the decrement in the IPSS storage score was smaller than group 1 (P=0.02, and in group 3, the decrement in the IPSS voiding score was smaller than group 1 (P=0.05. In groups 2 and 3 compared with group 1, improvements in the quality of life score, total score of Overactive Bladder Symptom Score, and short-form voiding score and storage score of International Continence Society were not statistically

  12. Blind separation of linear instantaneous mixtures of nonstationary surface myoelectric signals.

    Science.gov (United States)

    Farina, Dario; Févotte, Cédric; Doncarli, Christian; Merletti, Roberto

    2004-09-01

    Electromyographic (EMG) recordings detected over the skin may be mixtures of signals generated by different active muscles due to the phenomena related to volume conduction. Separation of the sources is necessary when single muscle activity has to be detected. Signals generated by different muscles may be considered uncorrelated but in general overlap in time and frequency. Under certain assumptions, mixtures of surface EMG signals can be considered as linear instantaneous but no a priori information about the mixing matrix is available when different muscles are active. In this study, we applied blind source separation (BSS) methods to separate the signals generated by two active muscles during a force-varying task. As the signals are non stationary, an algorithm based on spatial time-frequency distributions was applied on simulated and experimental EMG signals. The experimental signals were collected from the flexor carpi radialis and the pronator teres muscles which could be activated selectively for wrist flexion and rotation, respectively. From the simulations, correlation coefficients between the reference and reconstructed sources were higher than 0.85 for signals largely overlapping both in time and frequency and for signal-to-noise ratios as low as 5 dB. The Choi-Williams and Bessel kernels, in this case, performed better than the Wigner-Ville one. Moreover, the selection of time-frequency points for the procedure of joint diagonalization used in the BSS algorithm significantly influenced the results. For the experimental signals, the interference of the other source in each reconstructed source was significantly attenuated by the application of the BSS method. The ratio between root-mean-square values of the signals from the two sources detected over one of the muscles increased from (mean +/- standard deviation) 2.33 +/- 1.04 to 4.51 +/- 1.37 and from 1.55 +/- 0.46 to 2.72 +/- 0.65 for wrist flexion and rotation, respectively. This increment was

  13. Reconstructing Student Conceptions of Climate Change; An Inquiry Approach

    Science.gov (United States)

    McClelland, J. Collin

    No other environmental issue today has as much potential to alter life on Earth as does global climate change. Scientific evidence continues to grow; indicating that climate change is occurring now, and that change is a result of human activities (National Research Council [NRC], 2010). The need for climate literacy in society has become increasingly urgent. Unfortunately, understanding the concepts necessary for climate literacy remains a challenge for most individuals. A growing research base has identified a number of common misconceptions people have about climate literacy concepts (Leiserowitz, Smith, & Marlon 2011; Shepardson, Niyogi, Choi, & Charusombat, 2009). However, few have explored this understanding in high school students. This sequential mixed methods study explored the changing conceptions of global climate change in 90 sophomore biology students through the course of their participation in an eight-week inquiry-based global climate change unit. The study also explored changes in students' attitudes over the course of the study unit, contemplating possible relationships between students' conceptual understanding of and attitudes toward global climate change. Phase I of the mixed methods study included quantitative analysis of pre-post content knowledge and attitude assessment data. Content knowledge gains were statistically significant and over 25% of students in the study shifted from an expressed belief of denial or uncertainty about global warming to one of belief in it. Phase II used an inductive approach to explore student attitudes and conceptions. Conceptually, very few students grew to a scientifically accurate understanding of the greenhouse effect or the relationship between global warming and climate change. However, they generally made progress in their conceptual understanding by adding more specific detail to explain their understanding. Phase III employed a case study approach with eight purposefully selected student cases

  14. Mild and moderate pre-dialysis chronic kidney disease is associated with increased coronary artery calcium

    Directory of Open Access Journals (Sweden)

    Budoff M

    2011-12-01

    Full Text Available Sion K Roy, Albert Cespedes, Dong Li, Tae-Young Choi, Matthew J BudoffDivision of Cardiology, Department of Medicine, Los Angeles Biomedical Research Center at Harbor-UCLA Medical Center, Torrance, California, USABackground: It is increasingly evident that patients with chronic kidney disease (CKD are more likely to die from heart disease than kidney failure. This study evaluated whether pre-dialysis CKD is an independent risk factor for coronary artery calcium (CAC.Methods: A total of 544 consecutive patients who underwent CAC scoring were analyzed. Eleven patients requiring hemodialysis were excluded. Patients were divided into three groups: normal glomerular filtration rate (GFR (GFR > 90 mL/min/1.73 m2, mild CKD (90 ≥ GFR > 60 mL/min/1.73 m2, and moderate CKD (60 ≥ GFR > 30 mL/min/1.73 m2. Continuous and categorical variables were compared using analysis of variance and the χ2 statistic. A multiple logistic regression model was used for detecting the association between total CAC score and GFR. An unadjusted model was used, followed by a second model adjusted for covariates known to be related to CAC. Another multivariable binary logistic model predicting the presence of CAC (>10 was performed and odds of incidence of CAC (>10 were calculated among the three GFR subgroups.Results: After adjustment for covariates, patients with mild CKD had mean CAC scores 175 points higher than those with the referent normal GFR (P = 0.048, while those with moderate CKD had mean CAC scores 693 points higher than the referent (P < 0.001. After adjustment for covariates, patients with mild CKD were found to be 2.2 times more likely (95% confidence interval 1.3–3.7, P = 0.004 and patients with moderate CKD were 6.4 times more likely (95% confidence interval 2.9–14.3, P < 0.001 to have incident CAC compared with the group with normal GFR.Conclusion: Mild and moderate pre-dialysis CKD are independent risk factors for increased mean and incident CAC

  15. Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

    Directory of Open Access Journals (Sweden)

    Jang K

    2017-03-01

    Full Text Available Kyungho Jang,1,2,* Min-Kyoung Kim,3,4,* Jaeseong Oh,1 SeungHwan Lee,1 Joo-Youn Cho,1 Kyung-Sang Yu,1 Tai Kiu Choi,3 Sang-Hyuk Lee,3,4 Kyoung Soo Lim4 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Center for Clinical Pharmacology and Biomedical Research Institute, Chonbuk National University Medical School, Jeonju, 3Department of Psychiatry, 4Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea *These authors contributed equally to this work Purpose: Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1 to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the pharmacokinetics (PK of oseltamivir is controversial. The aim of this study was to investigate the effects of coadministering oseltamivir and dexamethasone on the PK of oseltamivir in healthy volunteers. Methods: An open-label, two-period, one-sequence, multiple-dose study was conducted in 19 healthy male volunteers. Oseltamivir (75 mg was orally administered on Day 1 and Day 8, and dexamethasone (1.5 mg was administered once daily from Day 3 to Day 8. Serial blood and urine samples were collected for PK analysis of oseltamivir and oseltamivir carboxylate on Day 1 and Day 8. Oseltamivir and oseltamivir carboxylate concentrations in plasma and urine were determined using liquid chromatography–tandem mass spectrometry. Results: Area under the plasma concentration–time curve (AUC of oseltamivir and oseltamivir carboxylate decreased after dexamethasone treatment for 6 days. The geometric mean ratio (90% confidence interval of the metabolic ratio

  16. Base-Displaced Intercalated Conformation of the 2-Amino-3-methylimidazo[4,5-f]quinoline N(2)-dG DNA Adduct Positioned at the Nonreiterated G(1) in the NarI Restriction Site.

    Science.gov (United States)

    Stavros, Kallie M; Hawkins, Edward K; Rizzo, Carmelo J; Stone, Michael P

    2015-07-20

    The conformation of an N(2)-dG adduct arising from the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), a potent food mutagen, was determined in 5'-d(C(1)T(2)C(3)X(4)G(5)C(6)G(7)C(8)C(9)A(10)T(11)C(12))-3':5'-d(G(13)A(14)T(15)G(16)G(17)C(18)G(19)C(20)C(21)G(22)A(23)G(24))-3'; X = N(2)-dG-IQ, in which the modified nucleotide X(4) corresponds to G(1) in the 5'-d(G(1)G(2)CG(3)CC)-3' NarI restriction endonuclease site. Circular dichroism (CD) revealed blue shifts relative to the unmodified duplex, consistent with adduct-induced twisting, and a hypochromic effect for the IQ absorbance in the near UV region. NMR revealed that the N(2)-dG-IQ adduct adopted a base-displaced intercalated conformation in which the modified guanine remained in the anti conformation about the glycosidic bond, the IQ moiety intercalated into the duplex, and the complementary base C(21) was displaced into the major groove. The processing of the N(2)-dG-IQ lesion by hpol η is sequence-dependent; when placed at the reiterated G(3) position, but not at the G(1) position, this lesion exhibits a propensity for frameshift replication [Choi, J. Y., et al. (2006) J. Biol. Chem., 281, 25297-25306]. The structure of the N(2)-dG-IQ adduct at the nonreiterated G(1) position was compared to that of the same adduct placed at the G(3) position [Stavros, K. M., et al. (2014) Nucleic Acids Res., 42, 3450-3463]. CD indicted minimal spectral differences between the G(1) vs G(3) N(2)-dG-IQ adducts. NMR indicated that the N(2)-dG-IQ adduct exhibited similar base-displaced intercalated conformations at both the G(1) and G(3) positions. This result differed as compared to the corresponding C8-dG-IQ adducts placed at the same positions. The C8-dG-IQ adduct adopted a minor groove conformation when placed at position G(1) but a base-displaced intercalated conformation when placed at position G(3) in the NarI sequence. The present studies suggest that differences in lesion bypass by hpol η may be

  17. Regarding the influence of sex and aging on dry eye disease

    Directory of Open Access Journals (Sweden)

    Han SB

    2017-09-01

    Full Text Available Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designed and conducted, and suggests that matching of age and sex is recommended in further researches on DED.1However, I would like to point out that there exist controversies regarding the effect of aging and sex on DED. Our previous study showed that age had no significant association with the prevalence of DED in adults of 65 years or older, while female sex was significantly related to increased prevalence of DED.2 By contrast, studies in the US demonstrated that prevalence of DED increased with aging both in male and female populations.3,4 Moreover, there are differences in pathophysiology of DED according to age. Although dysfunction of lacrimal and meibomian glands may play an important role in the pathogenesis of DED in the elderly, DED associated with visual display terminal use or contact lens wear is more common in young and middle-aged patients.5 Therefore, I believe these differences in the pathogenesis should be considered in the evaluation of the effects of sex and aging on DED.Authors' replyJong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim11Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South KoreaWe thank the author for taking a

  18. Orthotopic liver transplantation after the combined use of locoregional therapy and sorafenib for advanced hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Yoo EJ

    2013-06-01

    Full Text Available Eun Jin Yoo,1,* Hye Sun Shin,1,* Seung Up Kim,1,2,7 Dong Jin Joo,3,4 Jun Yong Park,1,2,7 Gi Hong Choi,3 Do Young Kim,1,2,7 Sang Hoon Ahn,1,2,7 Jinsil Seong,5 Myung Joo Koh,6 Kwang-Hyub Han,1,2,7 Chae Yoon Chon1,2,7 1Department of Internal Medicine, 2Institute of Gastroenterology, 3Department of Surgery, 4Research Institute for Transplantation, 5Department of Radiation Oncology, 6Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea; 7Liver Cirrhosis Clinical Research Center, Seoul, South Korea *These authors contributed equally to this work Abstract: We herein report a patient with advanced hepatitis B virus-related hepatocellular carcinoma (HCC beyond the Milan criteria. He underwent orthotopic liver transplantation after successful HCC downstaging that satisfied the University of California, San Francisco criteria, using concurrent chemoradiation therapy with a combination of repeated hepatic arterial infusion chemotherapy (HAIC and sorafenib. A 52-year-old male was diagnosed with advanced hepatitis B virus-related HCC beyond the Milan criteria. He underwent concurrent chemoradiation therapy (50 Gy with 20 fractions over 5 weeks with HAIC using 5-fluorouracil at a dose of 500 mg/day, which was administered during the first and fifth weeks of radiation therapy as an initial treatment modality. This was followed by the combined use of HAIC using 5-fluorouracil (500 mg/m2 for 5 hours on days 1–3 and cisplatin (60 mg/m2 for 2 hours on day 2 every 4 weeks (twelve cycles and sorafenib (from the third to the twelfth cycle of HAIC to treat the remaining HCC. Because a remarkable decrease in the tumor burden that satisfied the University of California, San Francisco criteria was observed after these combination treatments, the patient underwent orthotopic liver transplantation with curative aim and survived for 11 months without evidence of HCC recurrence. Keywords: hepatocellular carcinoma, liver transplantation

  19. Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production.

    Science.gov (United States)

    Zhu, Jili; Chaki, Moumita; Lu, Dongmei; Ren, Chongyu; Wang, Shan-Shan; Rauhauser, Alysha; Li, Binghua; Zimmerman, Susan; Jun, Bokkyoo; Du, Yong; Vadnagara, Komal; Wang, Hanquin; Elhadi, Sarah; Quigg, Richard J; Topham, Matthew K; Mohan, Chandra; Ozaltin, Fatih; Zhou, Xin J; Marciano, Denise K; Bazan, Nicolas G; Attanasio, Massimo

    2016-05-01

    Thrombotic microangiopathy (TMA) is a disorder characterized by microvascular occlusion that can lead to thrombocytopenia, hemolytic anemia, and glomerular damage. Complement activation is the central event in most cases of TMA. Primary forms of TMA are caused by mutations in genes encoding components of the complement or regulators of the complement cascade. Recently, we and others have described a genetic form of TMA caused by mutations in the gene diacylglycerol kinase-ε (DGKE) that encodes the lipid kinase DGKε (Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi MR, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji WZ, Overton JD, Mane SM, Nurnberg G, Altmuller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nurnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP. Nat Genet 45: 531-536, 2013; Ozaltin F, Li BH, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang CY, Chen P, Lu DM, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. J Am Soc Nephrol 24: 377-384, 2013). DGKε is unrelated to the complement pathway, which suggests that unidentified pathogenic mechanisms independent of complement dysregulation may result in TMA. Studying Dgke knockout mice may help to understand the pathogenesis of this disease, but no glomerular phenotype has been described in these animals so far. Here we report that Dgke null mice present subclinical microscopic anomalies of the glomerular endothelium and basal membrane that worsen with age and develop glomerular capillary occlusion when exposed to nephrotoxic serum. We found that induction of cyclooxygenase-2 and of the proangiogenic prostaglandin E2 are impaired in Dgke null kidneys and are associated with reduced expression of the

  20. Operator-sum representation for bosonic Gaussian channels

    Energy Technology Data Exchange (ETDEWEB)

    Ivan, J. Solomon; Sabapathy, Krishna Kumar; Simon, R. [Raman Research Institute, C. V. Raman Avenue, Sadashivanagar, Bangalore 560 080 (India); Optics and Quantum Information Group, The Institute of Mathematical Sciences, C.I.T. Campus, Tharamani, Chennai 600 113 (India)

    2011-10-15

    breaking channels. A characterization of extremality in terms of Kraus operators, originally due to Choi, is employed to show that all quantum-limited Gaussian channels are extremal. The fact that almost every noisy Gaussian channel can be realized as a product of a pair of quantum-limited channels is used to construct a discrete set of linearly independent Kraus operators for these noisy Gaussian channels, including the classical noise channel, and these Kraus operators have a particularly simple structure.

  1. Tai chi qigong as a means to improve night-time sleep quality among older adults with cognitive impairment: a pilot randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Chan AWK

    2016-09-01

    Full Text Available Aileen WK Chan, Doris SF Yu, KC Choi, Diana TF Lee, Janet WH Sit, Helen YL Chan The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China Purpose: Age-related cognitive decline is a growing public health concern worldwide. More than a quarter of adults with cognitive impairment experience sleep disturbance. The objective of this pilot study was to evaluate the preliminary effects of tai chi qigong (TCQ on improving the night-time sleep quality of older adults with cognitive impairment. Participants: Older adults with cognitive impairment who complain of sleep disturbance. Methods: A randomized controlled trial with two groups. Fifty-two subjects were recruited from two district elderly community centers and randomly assigned to either the TCQ group (n=27 or the control group (n=25. The intervention group received TCQ training consisting of two 60-minute sessions each week for 2 months. The control group was advised to maintain their usual activities. Sleep quality was measured by the Chinese Pittsburgh Sleep Quality Index. Quality of life was measured by Short-form 12, cognitive functions measured by mini-mental state examination, and subjective memory deficits measured by the memory inventory for Chinese. Results: Data were collected at baseline, 2 months, and 6 months. Significant results were noted at 6 months in the Chinese Pittsburgh Sleep Quality Index global score (P=0.004, sleep duration (P=0.003, habitual sleep efficiency (P=0.002, and the Short-form 12 mental health component (P<0.001. The TCQ participants reported better sleep quality and a better (quality of life mental health component than the control group. Conclusion: TCQ can be considered a useful nonpharmacological approach for improving sleep quality in older adults with cognitive impairment.Clinical trial registration: CUHK_CCT00448 (https://www2.ccrb.cuhk.edu.hk/registry/public/287. Keywords: cognitive decline, mind

  2. Convective heat transfer for incompressible laminar gas flow in micropassage with constant wall temperature

    Institute of Scientific and Technical Information of China (English)

    An; Gang; (

    2001-01-01

    [1]Tuckermann, D. B., Pease, R. F., Optimized convective cooling using micromachined structure, J. Electro-Chemical Society, 1982, 129(3): 98c.[2]Wu Peiyi, Little, W. A., Measurement of friction factor for the flow of gases in very fine channel used for microminiature Joule-Thomson refrigerators, Cryogenics, 1983, 23(5): 273.[3]Wu Peiyi, Little, W. A., Measurement of the heat transfer characteristics of gas flow in fine channel heat exchangers used for microminiature refrigerators, Cryogenics, 1984, 24(8): 415.[4]Choi, B., Barron, R. F., Warrington, R. O., Fluid flow and heat transfer in microtubes, ASME DSC, 1991, 32: 123.[5]Pfahler, J., Harley, J., Bua, H. et al., Gas and liquid flow in small channel, ASME DSC, 1991, 32: 49.[6]Beskok, A., Karniadakis, G. E., Simulation of slip-flow in complex micro-geometries, ASME DSC, 1992, 40: 355.[7]Mohiuddin, M. G., Li Dongqing, Dale, J. D., Heat transfer and fluid flow in microchannels, Int. J. Heat and Mass Transfer, 1997, 40(13): 3079.[8]Li, J. M., Wang, B. X., Peng, X. F., The wall effect for laminar flow through microtube, in Int. Center for Heat and Mass Transfer (ICHMT) Symposium on Molecular and Microscale Heat Transfer in Material Processing and Other Application Yokohama, Japan, (eds. Tanasawa, I., Nishio, S.), New York: Begell House,1996, 55-65.[9]Li, J. M., Wang, B. X., Peng, X. F., Laminar flow of gas through extremely narrow parallel plates, in Heat Transfer and Technology 1996, Proc. Fourth ISHT (ed. Wang, B. X.), Beijing: Higher Education Press, 1996, 318-322.[10]Li, J. M., Wang, B. X., Peng, X. F., Wall effect of gas laminar heat transfer in microtubes, Journal of Engineering Thermophysics (in Chinese), 1998, 19(5): 596.[11]Li, J. M., Wang, B. X., Peng, X. F., Laminar heat transfer of gas in microchannels between two paralled plates, Journal of Engineering Thermophysics (in Chinese), 1999, 20(2): 194.[12]Tao, W. Q., Numerical Heat Transfer (in Chinese), Xi

  3. Syn-Extensional Constrictional Folding of the Gwoira Rider Block, a Large Fault-Bounded Slice Atop the Mai'iu Low-Angle Normal Fault, Woodlark Rift.

    Science.gov (United States)

    Little, T. A.; Webber, S. M.; Norton, K. P.; Mizera, M.; Oesterle, J.; Ellis, S. M.

    2016-12-01

    uppermost part of a LANF, Coulomb fault mechanical analysis (after Choi and Buck, 2012) can be applied to field observations to provide an upper limit on LANF frictional strength (µf). Modelling constrains the µf for the Mai'iu Fault to ≤0.25, which suggests that the Mai'iu Fault is frictionally very weak.

  4. Sex differences in the effect of aging on dry eye disease

    Directory of Open Access Journals (Sweden)

    Ahn JH

    2017-08-01

    Full Text Available Jong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim1 1Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea Purpose: Aging is a major risk factor in dry eye disease (DED, and understanding sexual differences is very important in biomedical research. However, there is little information about sex differences in the effect of aging on DED. We investigated sex differences in the effect of aging and other risk factors for DED.Methods: This study included data of 16,824 adults from the Korea National Health and Nutrition Examination Survey (2010–2012, which is a population-based cross-sectional survey. DED was defined as the presence of frequent ocular dryness or a previous diagnosis by an ophthalmologist. Basic sociodemographic factors and previously known risk factors for DED were included in the analyses. Linear regression modeling and multivariate logistic regression modeling were used to compare the sex differences in the effect of risk factors for DED; we additionally performed tests for interactions between sex and other risk factors for DED in logistic regression models.Results: In our linear regression models, the prevalence of DED symptoms in men increased with age (R=0.311, P=0.012; however, there was no association between aging and DED in women (P>0.05. Multivariate logistic regression analyses showed that aging in men was not associated with DED (DED symptoms/diagnosis: odds ratio [OR] =1.01/1.04, each P>0.05, while aging in women was protectively associated with DED (DED symptoms/diagnosis: OR =0.94/0.91, P=0.011/0.003. Previous ocular surgery was significantly associated with DED in both men and women (men/women: OR =2.45/1.77 [DED symptoms] and 3.17/2.05 [DED diagnosis], each P<0.001. Tests for

  5. Relação entre Valor de Mercado e Ativo Intangível na Bovespa

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-07-01

    Full Text Available O valor de mercado das ações das empresas, negociados em bolsa, deve traduzir as expectativas dos investidores. E, muito embora os preços dessas ações estejam sujeitos à lei da oferta e da procura, diferentes métodos de avaliação, que utilizam diferentes indicadores contábeis, dados econômicos e interpretações subjetivas, podem gerar desvios no valor percebido das empresas. Este valor de mercado organizacional é conhecido como o preço da ação multiplicado pelo número das ações presentes para negociação. Esta equidade é uma questão de interesse para gestores contábeis, políticos e investigadores (Choi, 2000. É buscar a predição dos valores de mercado de empresas abertas, a partir das expectativas de valorização por parte dos acionistas. Para tanto é necessário entender a relação existente entre o retorno do ativo intangível e o retorno do valor de mercado das empresas da amostra, utilizada nos últimos cinco períodos, sendo esse o objetivo principal do trabalho. Este trabalho se enquadra numa pesquisa analítica, indutiva e básica (Collis; Hussey, 2005. Compreende uma pesquisa qualitativo-quantitativa na área de administração, finanças coorporativas e mercado financeiro brasileiro (Cherobim, 2003. Assim, responde-se à pergunta de pesquisa com algumas técnicas estatísticas, uma vez que o artigo não abrange todas as possibilidades de relações existentes entre as duas variáveis de forma estatística, mas tem forte capacidade de indicar a não predição do valor de mercado pelos ativos incorpóreos organizacionais.

  6. Femoral Lengthening for Limb Length Discrepancy After Septic Arthritis in Children%股骨牵拉延长术治疗新生儿化脓性关节炎后严重短肢畸形

    Institute of Scientific and Technical Information of China (English)

    郑振耀; 林子平; 郭霞

    1996-01-01

    A procedure for leg length discrepancy beyond 5.0 cm following acute purulent arthritis of the hip is introduced.Four cases aged 7-13 years with Choi's type ⅣB septic sequelae manifestated destruction of the femoral head and neck,dislocation or subluxation of the hip;and leg length discrepancy.All of them associated with multiple joint damage.The leg length discrepancy ranging 6.9-14.0 cm was measured with graphic scan.Continuous traction with external fixation was used(Ilizarov apparatus 3;Orthofix system 1).The lengthening of the involved femurs was 4.5-13.0 cm with an average.follow-up of 3 years.3 of the patients could ambulate independantly without any brace.The authors suggest physical therapy(PT)be emphasized during traction,the traction should be suspended as soon as movements of the knee decrease,and reuse after intensive PT.The effect of this method is satisfactory.%介绍一种治疗急性化脓性髋关节炎后合并下肢不等长超过5.0 cm患儿的方法.本组共治疗4例蔡氏ⅣB型新生儿急性化脓性髋关节炎后遗症患儿,年龄7~13岁,临床症状有股骨头、颈的完全破坏,髋关节全或半脱位及双下肢不等长.术前均并发下肢其他关节化脓性炎症,术前用扫描图像法测量双下肢长度相差6.9~14.0 cm.采用外固定骨痂牵拉延长术治疗,3例外固定架为Ilizarov环形架,1例为Orthofix单侧架,牵拉后延长股骨4.5~13.0cm.术后随访2.5~3.5年,其中3例可以不用支具独立行走.该方法疗效满意,牵拉治疗中应重视关节功能练习,一旦膝关节功能减退,则暂停一段时间,加强功能练习后再进行牵拉.

  7. Optimal medical therapy for secondary prevention after an acute coronary syndrome: 18-month follow-up results at a tertiary teaching hospital in South Korea

    Directory of Open Access Journals (Sweden)

    Byeon HJ

    2016-02-01

    Full Text Available Hee Ja Byeon,1,* Young-Mo Yang,2,* Eun Joo Choi21Department of Pharmacy, Chosun University Hospital, 2Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju, South Korea*These authors contributed equally to this workBackground: Acute coronary syndrome (ACS is a fatal cardiovascular disease caused by atherosclerotic plaque erosion or rupture and formation of coronary thrombus. The latest guidelines for ACS recommend the combined drug regimen, comprising aspirin, P2Y12 inhibitor, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, β-blocker, and statin, at discharge after ACS treatment to reduce recurrent ischemic cardiovascular events. This study aimed to examine prescription patterns of secondary prevention drugs in Korean patients with ACS after hospital discharge, to access the appropriateness of secondary prevention drug therapy for ACS, and to evaluate whether to persistently use discharge medications for 18 months.Methods: This study was retrospectively conducted with the patients who were discharged from the tertiary hospital, located in South Korea, after ACS treatment between September 2009 and August 2013. Data were collected through electronic medical record.Results: Among 3,676 patients during the study period, 494 were selected based on inclusion and exclusion criteria. The regimen of aspirin + clopidogrel + β-blocker + angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker + statin was prescribed to 374 (75.71% patients with ACS at discharge. Specifically, this regimen was used in 177 (69.69% unstable angina patients, 44 (70.97% non-ST-segment elevation myocardial infarction patients, and 153 (85.96% ST-segment elevation myocardial infarction patients. Compared with the number of ACS patients with all five guideline-recommended drugs at discharge, the number of ACS patients using them 12 (n=169, 34.21% and 18 (n=105, 21.26% months after discharge tended to be gradually

  8. Prostate cancer patients may have an increased risk of coexisting advanced colorectal neoplasms

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    Ko SH

    2016-09-01

    Full Text Available Sun-Hye Ko,1,2 Myong Ki Baeg,2,3 Woong Jin Bae,4 Pumsoo Kim,3 Myung-Gyu Choi2 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; 2Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 3Department of Internal Medicine, International St Mary’s Hospital, Catholic Kwandong University, Incheon, South Korea; 4Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, South Korea Background/aims: Patients being treated for prostate cancer (PCa have an increased risk of developing colorectal cancer. However, whether PCa patients are inherently at a higher risk of colorectal neoplasms (CRNs is unknown. We aimed to investigate the risk of CRNs in PCa patients.Materials and methods: Patients who had been diagnosed with PCa at a tertiary medical center and had colonoscopy within 1 year of the PCa diagnosis were investigated. Patients were propensity-matched 1:2 by age and body mass index to asymptomatic control subjects who had undergone colonoscopy for routine health screening. CRN was defined as histological confirmation of an adenoma or adenocarcinoma component. Advanced CRN was defined as any of the following: 1 histological findings of high-grade dysplasia, 2 inclusion of villous features, 3 tumor ≥1 cm in size, or 4 presence of an adenocarcinoma. Risk factors for CRN and advanced CRN were evaluated by univariate and multivariate analysis.Results: A total of 191 patients diagnosed with PCa had colonoscopies within 1 year of PCa diagnosis. Of these, 23 patients with a history of previous malignancy and seven with incomplete colonoscopies were excluded, leaving 161 patients in the PCa group. Although presence of PCa was not a significant risk factor for CRN by multivariate analysis, PCa was a significant risk factor for advanced CRN (odds ratio [OR] 3.300; 95% confidence interval [CI] 1.766–6.167; P<0

  9. ANALYSIS OF RISK FACTORS OF CIRRHOSIS COMPLICATED BY HEPATOGENOUS DIABETES%肝硬化发生肝源性糖尿病的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    鲍中英; 苑晓冬; 段淑红

    2011-01-01

    [Objective] To analyse the risk factors of hepatogenous diabetes in liver cirrhosis patients. [Methods] One hundred and eighty cirrhosis cases were enrolled and retrospectively analyzed including age, sex, causes and course of cirrhosis, score of Child-pugh, TG (triglyceride), Choi (cholesterol) and the concentrations of serum Fe+to observe the relationship between cirrhosis complicated by hepatogenous diabetes and above indices. SPSS 11.5 software was used for statistic analysis. [Results] The Logistic regression showed that cirrhosis complicated by hepatogenous diabetes had significant relationship with the age, courses of cirrhosis, grade of child-pugh score and infection of HCV (P< 0.05). [Conclusion] The risk factors of cirrhosis complicated by hepatogenous diabetes are age, courses of cirrhosis, grade of child-pugh score and infection of HCV.%[目的]分析肝硬化发生肝源性糖尿病的危险因素.[方法]对180例明确诊断肝硬化的住院病例进行回顾性分析,包括年龄、性别、肝硬化的病因、病程、Child-pugh分级、甘油三酯、胆固醇、血清铁水平,探讨肝硬化发生肝源性糖尿病与上迷指标的相关性,数据分析应用SPSS11.5统计学软件.[结果]经Logistic回归分析显示肝硬化发生肝源性糖尿病与年龄、病程、child-pugh分级、丙型肝炎病毒感染的相关性具有统计学意义(P < 0.05).[结论]肝硬化患者发生肝源性糖尿病的独立危险因素是年龄、肝病病程、child-pugh分级和丙型肝炎病毒感染.

  10. Dextran-b-poly(L-histidine copolymer nanoparticles for pH-responsive drug delivery to tumor cells

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    Hwang JH

    2013-08-01

    Full Text Available Jong-Ho Hwang,1,2 Cheol Woong Choi,1 Hyung-Wook Kim,1 Do Hyung Kim,3 Tae Won Kwak,3 Hye Myeong Lee,3 Cy Hyun Kim,3 Chung Wook Chung,3 Young-Il Jeong,3 Dae Hwan Kang1,3 1Department of Internal Medicine, Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea; 2Department of Internal Medicine, Busan Medical Center, Yeonje-gu, Busan, Republic of Korea; 3National Research and Development Center for Hepatobiliary Disease, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea Purpose: Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-b-poly(L-histidine (DexPHS copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting. Methods and results: A DexPHS block copolymer was synthesized by attaching the reductive end of dextran to the amine groups of poly(L-histidine. pH-responsive nanoparticles incorporating doxorubicin were fabricated and studied in HuCC-T1 cholangiocarcinoma cells. Synthesis of DexPHS was confirmed by 1H nuclear magnetic resonance spectroscopy, with specific peaks of dextran and PHS observed at 2–5 ppm and 7.4–9.0 ppm, respectively. DexPHS nanoparticles showed changes in particle size with pH sensitivity, ie, the size of the nanoparticles increased at an acidic pH and decreased at a basic pH. DexPHS block copolymer nanoparticles incorporating doxorubicin were prepared using the nanoprecipitation dialysis method. The doxorubicin release rate was increased at acidic pH compared with basic pH, indicating that DexPHS nanoparticles have pH-sensitive properties and that drug release can be controlled by variations in pH. The antitumor activity of DexPHS nanoparticles incorporating doxorubicin were studied using HuCC-T1

  11. Functional and histological improvement after everolimus rescue of chronic allograft dysfunction in renal transplant recipients

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    Chow KM

    2015-05-01

    Full Text Available Kai Ming Chow,1 Cheuk Chun Szeto,1 Fernand Mac-Moune Lai,2 Cathy Choi-Wan Luk,1 Bonnie Ching-Ha Kwan,1 Chi Bon Leung,1 Philip Kam-Tao Li1 1Department of Medicine and Therapeutics, 2Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Background: We tested the strategy of mTOR inhibitors with calcineurin inhibitor minimization in renal transplant recipients with known chronic allograft dysfunction.Methods: In this open-label, single-arm study, renal transplant patients were recruited after biopsy-confirmed chronic allograft dysfunction in the absence of acute rejection episode within 2 months, with proteinuria <0.8 g/day, and serum creatinine <220 µmol/L or estimated glomerular filtration rate >40 mL/min/1.73 m2. They were converted to everolimus (aiming for trough everolimus level 3–8 ng/mL with cyclosporine minimization, to assess the effect on renal function, rate of glomerular filtration rate decline, and longitudinal transplant biopsy at 12 months.Results: Seventeen Chinese patients (median transplant duration, 4.2 years were recruited; no patients discontinued study medication. The mean slope of the glomerular filtration rate over time was -4.31±6.65 mL/min/1.73 m2 per year in the year before everolimus, as compared with 1.29±5.84 mL/min/1.73 m2 per year in the 12 months of everolimus therapy, a difference of 5.61 mL/min/1.73 m2 per year (95% confidence interval [CI], 0.40–10.8 favoring everolimus therapy (P=0.036. Serial renal biopsy histology showed significant decrease of tubular atrophy (15.7%±11.3% versus 7.1%±7.3%, P=0.005 and interstitial fibrosis (14.8%±11.5% versus 7.2%±8.2%, P=0.013. Intrarenal expression of TGF-β1 mRNA showed a nonsignificant decrease after everolimus treatment.Conclusion: In renal transplant recipients with biopsy-confirmed chronic allograft dysfunction, we found a significant beneficial effect of everolimus rescue therapy

  12. Arsenic Speciation in Old Mine Waste Site in Korea - Preliminary Results

    Science.gov (United States)

    Kim, Y.; Woo, N.; Choi, I.; Yoon, C.; Yoon, H.

    2004-05-01

    The ulsan mine, which is known as an important producer of iron, tungsten and arsenic ores in southeastern Korea, is located in Gyeongsangnam Province. This mine is of calcareous skarn deposit represented by ore pipe consisting mainly of magnetite with minor scheelite, sulphides, sulphosalts, arsenides and sulpharsenides (Choi et.al. 1993). A total of 13 groundwater samples and a surface-water sample at an adjacent creek, Dalcheon, were collected in January 2004. Most samples showed neutral pH ranges and normal ORP and temperature conditions. But one sample showed basic and extremely reducing condition, and another one was with relatively high temperature. Results of chemical analysis indicate that total arsenic concentrations of all samples are exceeding the WHO guideline for drinking water quality (10 ug/L), and 64% of those are over the Korean Drinking Water Guideline (KDWG) of 50 ug/L. Especially, arsenic concentrations in two samples exceed 1000 ug/L. Concentrations of some elements like Al, Fe, Mn, SO4 are over the KDWG in several samples, too. Consequence of arsenic speciation using IC-ICP-MS, arsenic exists as three species; arsenite, arsenate, and monomethylarsonate (MMA). Arsenite detected in three groundwater samples. Two of these were from wells in the tailing dam, and the other was the one with basic pH and extremely reducing condition. Arsenic in a surface-water sample mainly exists as MMA form that has lower toxicity than inorganic species. This indicates that microbial activity is the important factor to explain risks in the studied environment. Except for these samples, arsenic exists as arsenate form. Samples were prepared in two ways; 1) acidified water samples with phosphoric acid to the pH less than 2 and filtered through 0.45 um filter papers, and 2) filtered water samples first and then acidified. Comparison of the analysis from the two sample sets indicates that significant mass of arsenic appears to be with clay and the pH condition of the

  13. Quantitative comparison of cognitive behavioral therapy and music therapy research: a methodological best-practices analysis to guide future investigation for adult psychiatric patients.

    Science.gov (United States)

    Silverman, Michael J

    2008-01-01

    While the music therapy profession is relatively young and small in size, it can treat a variety of clinical populations and has established a diverse research base. However, although the profession originated working with persons diagnosed with mental illnesses, there is a considerable lack of quantitative research concerning the effects of music therapy with this population. Music therapy clinicians and researchers have reported on this lack of evidence and the difficulty in conducting psychosocial research on their interventions (Choi, 1997; Silverman, 2003a). While published studies have provided suggestions for future research, no studies have provided detailed propositions for the methodology and design of meticulous high quality randomized controlled psychiatric music therapy research. How do other psychotherapies accomplish their databases and could the music therapy field borrow from their rigorous "methodological best practices" to strengthen its own literature base? Therefore, as the National Institutes of Mental Health state the treatment of choice for evidence-based psychotherapy is cognitive behavioral therapy (CBT), aspects of this psychotherapy's literature base were analyzed. The purpose of this literature analysis was to (a) analyze and identify components of high-quality quantitative CBT research for adult psychiatric consumers, (b) analyze and identify the variables and other elements of existing quantitative psychiatric music therapy research for adult consumers, and (c) compare the two data sets to identify the best methodological designs and variables for future quantitative music therapy research with the mental health population. A table analyzing randomized and thoroughly controlled studies involving the use of CBT for persons with severe mental illnesses is included to determine chief components of high-quality experimental research designs and implementation of quantitative clinical research. The table also shows the same analyzed

  14. Effects of tai chi qigong on psychosocial well-being among hidden elderly, using elderly neighborhood volunteer approach: a pilot randomized controlled trial

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    Chan AW

    2017-01-01

    Full Text Available Aileen WK Chan, Doris SF Yu, KC Choi The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Purpose: To test the feasibility and preliminary effectiveness of a tai chi qigong program with the assistance of elderly neighborhood volunteers in strengthening social networks and enhancing the psychosocial well-being of hidden elderly. Patients and methods: “Hidden elderly” is a term used to describe older adults who are socially isolated and refuse social participation. This pilot randomized controlled trial recruited 48 older adults aged 60 or above who did not engage in any social activity. They were randomized into tai chi qigong (n=24 and standard care control (n=24 groups. The former group underwent a three-month program of two 60-minute sessions each week, with the socially active volunteers paired up with them during practice. Standard care included regular home visits by social workers. Primary outcomes were assessed by means of the Lubben social network and De Jong Gieveld loneliness scales, and by a revised social support questionnaire. Secondary outcomes were covered by a mental health inventory and the Rosenberg self-esteem scale, and quality of life by using the 12-Item Short Form Health Survey. Data was collected at baseline, and at three and six months thereafter. Results: The generalized estimating equations model revealed general improvement in outcomes among participants on the tai chi qigong program. In particular, participants reported a significantly greater improvement on the loneliness scale (B=-1.32, 95% confidence interval [CI] -2.54 to -0.11, P=0.033 and the satisfaction component of the social support questionnaire (B=3.43, 95% CI 0.10–6.76, P=0.044 than the control group. Conclusion: The pilot study confirmed that tai chi qigong with elderly neighborhood volunteers is a safe and feasible social intervention for hidden elderly. Its potential benefits in

  15. Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging

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    Key J

    2016-08-01

    Full Text Available Jaehong Key,1,2 Deepika Dhawan,3 Christy L Cooper,3,4 Deborah W Knapp,3 Kwangmeyung Kim,5 Ick Chan Kwon,5 Kuiwon Choi,5 Kinam Park,1,6 Paolo Decuzzi,7–9 James F Leary1,3,41Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; 2Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea; 3School of Veterinary Medicine-Department of Basic Medical Sciences, Purdue University, West Lafayette, 4Birck Nanotechnology Center at Discovery Park, Purdue University, West Lafayette, IN, USA; 5Biomedical Research Center, Korea Institute of Science and Technology, Sungbook-Gu, Seoul, Republic of Korea; 6Department of Pharmaceutics, Purdue University, West Lafayette, IN, 7Department of Translational Imaging, 8Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX USA; 9Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia (IIT, Genova, Italy Abstract: While current imaging modalities, such as magnetic resonance imaging (MRI, computed tomography, and positron emission tomography, play an important role in detecting tumors in the body, no single-modality imaging possesses all the functions needed for a complete diagnostic imaging, such as spatial resolution, signal sensitivity, and tissue penetration depth. For this reason, multimodal imaging strategies have become promising tools for advanced biomedical research and cancer diagnostics and therapeutics. In designing multimodal nanoparticles, the physicochemical properties of the nanoparticles should be engineered so that they successfully accumulate at the tumor site and minimize nonspecific uptake by other organs. Finely altering the nano-scale properties can dramatically change the biodistribution and tumor accumulation of nanoparticles in the body. In this study, we engineered multimodal nanoparticles for both MRI, by using ferrimagnetic nanocubes (NCs, and near infrared fluorescence imaging

  16. Pharmacokinetic and pharmacodynamic interactions between metformin and a novel dipeptidyl peptidase-4 inhibitor, evogliptin, in healthy subjects

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    Rhee SJ

    2016-08-01

    Full Text Available Su-jin Rhee,1,* YoonJung Choi,1,* SeungHwan Lee,1,2 Jaeseong Oh,1 Sung-Jin Kim,3 Seo Hyun Yoon,1 Joo-Youn Cho,1 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; 2Clinical Trials Center, Seoul National University Hospital, Seoul, Republic of Korea; 3Department of Clinical Development, Dong-A ST Co., Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Evogliptin is a newly developed dipeptidyl peptidase-4 (DPP-4 inhibitor, which is expected to be combined with metformin for treating type 2 diabetes mellitus. We investigated the potential pharmacokinetic and pharmacodynamic interactions between evogliptin and metformin. A randomized, open-label, multiple-dose, six-sequence, three-period crossover study was conducted in 36 healthy male subjects. All subjects received three treatments, separated by 7-day washout intervals: evogliptin, 5 mg od for 7 days (EVO; metformin IR, 1,000 mg bid for 7 days (MET; and the combination of EVO and MET (EVO + MET. After the last dose in a period, serial blood samples were collected for 24 hours for pharmacokinetic assessments. During steady state, serial blood samples were collected for 2 hours after an oral glucose tolerance test, and DPP-4, active glucagon-like peptide-1, glucose, glucagon, insulin, and C-peptide were measured to assess pharmacodynamic properties. EVO + MET and EVO showed similar steady state maximum concentration and area under the concentration–time curve at steady state values for evogliptin; the geometric mean ratios (90% confidence interval were 1.06 (1.01–1.12 and 1.02 (0.99–1.06, respectively. EVO + MET slightly reduced steady state maximum concentration and area under the concentration–time curve at steady state values for metformin compared to MET, with geometric mean ratios (90% confidence interval of 0.84 (0.79

  17. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

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    Kim YH

    2015-02-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Hyeong-Seok Lim,1 Mi Young Bahng,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, College of Medicine, University of Ulsan, 2Clinical Development Department, Dong-A ST Co, Ltd, Seoul, Republic of Korea Background: “Udenafil” is a phosphodiesterase-5 inhibitor indicated for erectile dysfunction. “Dapoxetine” is a serotonin transport inhibitor indicated for premature ejaculation. The aim of the study reported here was to investigate the pharmacokinetic drug interaction between udenafil and dapoxetine in healthy male subjects. Methods: An open-label, three-treatment, six-sequence, three-period crossover study was performed in healthy male subjects. In varying sequences, each subjects received single oral doses of udenafil 200 mg, dapoxetine 60 mg, and both treatments. The periods were separated by a washout period of 7 days. Serial blood samples were collected up to 48 hours after dosing. The plasma concentrations of udenafil and dapoxetine were determined using a validated liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were obtained by non-compartmental analysis. Tolerability was assessed throughout the study. Results: Twenty-three healthy subjects completed the study. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for udenafil were 0.923 (90% confidence interval [CI]: 0.863–0.987 and 0.864 (90% CI: 0.789–0.947, respectively. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for dapoxetine were 1.125 (90% CI: 1.044–1.213 and 0.837 (90% CI: 0.758–0.925, respectively. There were no serious adverse events reported, and none of the subjects dropped out due to adverse events

  18. Perceptions of a HIV testing message targeted for at-risk adults with low functional health literacy

    Science.gov (United States)

    Hunter, Susan L.

    This study analyses warehoused data collected by Georgia State University and Centers for Disease Control and Prevention (GSU/CDC) researchers after developing an HIV testing message for urban adults with low functional health literacy. It expands previous work by examining data collected when 202 primarily African-American homeless clients of an urban community based organization (CBO) reviewed both the low literacy brochure (Wallace et al., 2006) and a standard HIV brochure (Georgia Department of Human Resources, 1997). Participants' health literacy was assessed using 2 measures; the Rapid Estimate of Adult Literacy in Medicine or REALM (Davis, Crouch, Long & Green) and the Test of Functional Health Literacy Assessment or TOFHLA (Nurss, Parker & Baker, 2001). HIV risk was determined using an interview questionnaire developed by the research group (Belcher, Deming, Hunter & Wallace, 2005) which allowed participants to self-report recent alcohol and drug use, sexual behavior, sexually transmitted disease (STD) history and exposure to abuse and sexual coercion. Open-ended response questions regarding readability, understanding, main message, and importance for each brochure provided the qualitative data. This analysis confirms previous work showing accessibility, readability, cultural sensitivity and user-friendly formatting are important when attempting to engage at-risk adults with varying levels of functional health literacy in an HIV testing message. The visual aspects of the brochure can be essential in capturing the reader's attention and should be relevant to the target audience (Wallace, Deming, Hunter, Belcher & Choi, 2006). Mono-colored graphics may be perceived as dated and irrelevant or worse yet, threatening to some readers. Whenever possible culturally appropriate color photos of people depicting relevant content should replace excess text and difficult medical terms should be eliminated. Wording on the cover and within the brochure should be used to

  19. In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs

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    Kim JS

    2016-06-01

    Full Text Available Jeong Soo Kim,1 Kwang Ho Cha,1 Seung Yeob Kang,1 Donghan Won,1 Sun Woo Jang,1 Miwon Son,1 Moon Ho Son,1 Ho Jung Choi,2 Young Won Lee,2 Myung Joo Kang3 1Dong-A Pharmaceutical Co. Ltd., Giheung-gu, Yongin, Gyeonggi, 2College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungnam National University, Daejeon, 3College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, South Korea Objective: DA-9601, an extract of Artemisia asiatica containing eupatilin and jaceosidin as active compounds, has been prescribed to treat gastritis in Asia. In recent times, sustained-release, floating gastroretentive (GR tablets of DA-9601 are available on the market. In the present study, the physical properties and in vitro drug release profile, in vivo gastric residence time, and gastroprotective effect of GR tablet were compared to those of immediate release (IR tablets of DA-9601.Method: In vitro buoyancy behavior (floating lag time and duration and release profile of eupatilin were assessed in acidic medium. The in vivo intragastric behaviors of the barium sulfate-loaded IR and GR tablets were evaluated in beagle dogs by radiographic studies. Local gastroprotective effect was compared in an experimentally induced gastric lesion in beagle dogs after oral administration of IR (three times per day or GR (twice daily tablets for 15 days.Results: Upon contact with gastric juice, a low-density floating tablet (apparent density of 0.93 g/cm3 was buoyant on the medium and was upheld for 14 hours, providing sustained drug release profile, whereas the IR tablet disintegrated within 10 minutes, showing complete drug release within 2 hours. In vivo radiographic studies showed that the GR tablet was retained for >4 hours in the stomach. Both DA-9601 formulations remarkably alleviated gastric mucosal injury compared to placebo group, when observed by gastric endoscopy.Conclusion: Twice-daily GR tablets exhibited a prolonged gastric residence

  20. Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

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    Seo JH

    2015-07-01

    Full Text Available Jae Hong Seo, Jung Bae Park, Woong-Kee Choi, Sunhwa Park, Yun Jin Sung, Euichaul Oh, Soo Kyung Bae College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea Objective: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavailability of cilostazol.Methods: Cilostazol mesylate and cilostazol besylate were synthesized from cilostazol by acid addition reaction with methane sulfonic acid and benzene sulfonic acid, respectively. The salt preparations were characterized by nuclear magnetic resonance spectroscopy. The water contents, hygroscopicity, stress stability, and photostability of the two cilostazol salts were also determined. The dissolution profiles in various pH conditions and pharmacokinetic studies in rats were compared with those of cilostazol-free base.Results: The two cilostazol salts exhibited good physicochemical properties, such as nonhygroscopicity, stress stability, and photostability, which make it suitable for the preparation of pharmaceutical formulations. Both cilostazol mesylate and cilostazol besylate showed significantly improved dissolution rate and extent of drug release in the pH range 1.2–6.8 compared to the cilostazol-free base. In addition, after oral administration to rats, cilostazol mesylate and cilostazol besylate showed increases in Cmax and AUCt of approximately 3.65- and 2.87-fold and 3.88- and 2.94-fold, respectively, compared to cilostazol-free base.Conclusion: This study showed that two novel salts of cilostazol, such as cilostazol mesylate and cilostazol besylate, could be used to enhance its oral absorption. The findings warrant further preclinical and clinical studies on cilostazol mesylate and

  1. Application of a Two-Storage Zone Model to Characterize Transport and Reaction of Solutes and Solute Tracers in Streams and Wetlands

    Science.gov (United States)

    Harvey, J. W.; Newlin, J. T.

    2004-05-01

    Natural streams and wetlands exchange water and solutes between the main flow zone and a complex assemblage of "transient storage" zones that include stagnant water in pools, areas of flow recirculation, and subsurface flow paths through bed sediments and deeper alluvial sediments. Exchange between faster moving waters of the main flow zone and the slowly moving waters in storage zones results in delayed downstream transport of solutes, relative to what would be predicted from velocity measurements in the main flow zone. The transient storage concept is useful particularly for understanding the fate and transport of contaminants in streams, such as nutrients and metals, because solutes transported into storage zones come in close contact with reactive substrates such as sediment, periphyton, and macrophyte leaves. Delayed transport and characterization of transient storage zones can be quantified with solute tracer injections and modeling. Many of the widely used stream transport models that consider transient storage, such as the OTIS-P model (Runkel, USGS WRIR 98-4018, 1998), use only a single storage zone (i.e., linear reservoir with exponential residence time distribution) to account for transient storage. Choi et al. (WRR, 36:1511, 2000) showed that a model with two independent storage zones improved the characterization of transient storage in systems having both `slow' and `fast' exchange zones while retaining an appropriate level of model simplicity. We modified the OTIS-P model to include the option of simulating transport by allowing for exchange with two independent storage zones. The new model package, called OTIS-2Stor, also incorporates new options for weighting tracer concentration measurements while estimating the parameters of the model using the same non-linear least squares regression routine that is included in OTIS-P. Our experiences in headwater channels of Indiana and in the Florida Everglades demonstrate that, if used in conjunction with

  2. Nitrate from Drinking Water and Diet and Bladder Cancer Among Postmenopausal Women in Iowa.

    Science.gov (United States)

    Jones, Rena R; Weyer, Peter J; DellaValle, Curt T; Inoue-Choi, Maki; Anderson, Kristin E; Cantor, Kenneth P; Krasner, Stuart; Robien, Kim; Freeman, Laura E Beane; Silverman, Debra T; Ward, Mary H

    2016-11-01

    nitrite intakes were not associated with bladder cancer. Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. Citation: Jones RR, Weyer PJ, DellaValle CT, Inoue-Choi M, Anderson KE, Cantor KP, Krasner S, Robien K, Beane Freeman LE, Silverman DT, Ward MH. 2016. Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspect 124:1751-1758; http://dx.doi.org/10.1289/EHP191.

  3. Relação entre Valor de Mercado e Ativo Intangível na Bovespa.

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    Eduardo de Paula e Silva Chaves

    2013-09-01

    Full Text Available O valor de mercado das ações das empresas, negociados em bolsa, deve traduzir as expectativas dos investidores. E, muito embora os preços dessas ações estejam sujeitos à lei da oferta e da procura, diferentes métodos de avaliação, que utilizam diferentes indicadores contábeis, dados econômicos e interpretações subjetivas, podem gerar desvios no valor percebido das empresas. Este valor de mercado organizacional é conhecido como o preço da ação multiplicado pelo número das ações presentes para negociação. Esta equidade é uma questão de interesse para gestores contábeis, políticos e investigadores (Choi, 2000. É buscar a predição dos valores de mercado de empresas abertas, a partir das expectativas de valorização por parte dos acionistas. Para tanto é necessário entender a relação existente entre o retorno do ativo intangível e o retorno do valor de mercado das empresas da amostra, utilizada nos últimos cinco períodos, sendo esse o objetivo principal do trabalho. Este trabalho se enquadra numa pesquisa analítica, indutiva e básica (Collis; Hussey, 2005. Compreende uma pesquisa qualitativo-quantitativa na área de administração, finanças coorporativas e mercado financeiro brasileiro (Cherobim, 2003. Assim, responde-se à pergunta de pesquisa com algumas técnicas estatísticas, uma vez que o artigo não abrange todas as possibilidades de relações existentes entre as duas variáveis de forma estatística, mas tem forte capacidade de indicar a não predição do valor de mercado pelos ativos incorpóreos organizacionais. Palavras-chave:   Ativos

  4. Silver nanoparticles cause complications in pregnant mice

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    Zhang XF

    2015-11-01

    Full Text Available Xi-Feng Zhang,1,2 Jung-Hyun Park,1 Yun-Jung Choi,1 Min-Hee Kang,1 Sangiliyandi Gurunathan,1 Jin-Hoi Kim11Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea; 2College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, People’s Republic of ChinaBackground: Silver nanoparticles (AgNPs have attracted much interest and have been used for antibacterial, antifungal, anticancer, and antiangiogenic applications because of their unique properties. The increased usage of AgNPs leads to a potential hazard to human health. However, the potential effects of AgNPs on animal models are not clear. This study was designed to investigate the potential impact of AgNPs on pregnant mice.Methods: The synthesis of AgNPs was performed using culture extracts of Bacillus cereus. The synthesized AgNPs were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. AgNPs were administrated into pregnant mice via intravenous infusion at 1.0 mg/kg doses at 6.5 days postcoitum (dpc. At 13.5, 15.5, and 17.5 dpc, the pregnant mice were euthanized, and the embryo and placenta were isolated. The meiotic status of oocytes was evaluated. DNA methylation studies were performed, and aberrant imprinting disrupted fetal, placental, and postnatal development. Quantitative real-time polymerase chain reaction analysis and Western blot were used to analyze various gene expressions.Results: The synthesized AgNPs were uniformly distributed and were spherical in shape with an average size of 8 nm. AgNPs exposure increased the meiotic progression of female germ cells in the fetal mouse ovaries, and maternal AgNP exposure significantly disrupted imprinted gene expression in 15.5 dpc embryos and placentas, such as Ascl2, Snrpn, Kcnq1ot1, Peg3, Zac1, H19, Igf2r, and Igf2; DNA methylation studies revealed that AgNPs exposure significantly altered the methylation levels of

  5. High Impact Papers from April – June, 2015

    Directory of Open Access Journals (Sweden)

    Editorial Office

    2016-06-01

    Full Text Available High impact papers from a particular Issue are selected based on the quality of the article and the number of citations. High impact papers are typically recognized once the Issuecompletes the publication time period of 12 months.Following articles are recognized as High Impact Papers from April - June, 2015:Vazquez-Quino L, Huerta-Hernandez C, Calvo O, Deweese M. Evaluation of a novel reference chamber “stealth chamber” through Monte Carlo simulations and experimental data. Int J Cancer Ther Oncol 2015; 3(2:3222. DOI: 10.14319/ijcto.32.22Read                      Download                           Narayanasamy G, Feddock J, Gleason J, McGarry R, Molloy J. CBCT-based dosimetric verification and alternate planning techniques to reduce the normal tissue dose in SBRT of lung patients. Int J Cancer Ther Oncol 2015; 3(2:3218. DOI: 10.14319/ijcto.32.18Read                      Download                           Adams B, Herold M, Ferstl E, Choi J, Zhu S, Bogdanov V, El-Rayes B, Sun A, Liotta D, Snyder J, Shoji M. Anticancer effects of monocarbonyl analogs of curcumin: Oxidative stress, nuclear translocation and modulation of AP-1 and NF-κB. Int J Cancer Ther Oncol 2015; 3(2:3219.DOI: 10.14319/ijcto.32.19Read                      Download           (High impact papers from July-September, 2015 will be recognized in the next Issue of the IJCTO

  6. Femtosecond laser writing of new type of waveguides in silver containing glasses (Conference Presentation)

    Science.gov (United States)

    Abou Khalil, Alain; Bérubé, Jean-Philippe; Danto, Sylvain; Desmoulin, Jean-Charles; Cardinal, Thierry; Petit, Yannick G.; Canioni, Lionel; Vallée, Réal

    2017-03-01

    Femtosecond laser writing in glasses is a growing field of research and development in photonics, since it provides a versatile, robust and efficient approach to directly address 3D material structuring. Laser-glass interaction process has been studied for many years, especially the local changes of the refractive index that have been classified by three distinct types (types I, II and III, respectively). These refractive index modifications are widely used for the creation of photonics devices such as waveguides [1], couplers, photonic crystals to fabricate integrated optical functions in glasses for photonic applications as optical circuits or integrated sensors. Femtosecond laser writing in a home-developed silver containing zinc phosphate glasses induces the creation of fluorescent silver clusters distributed around the laser-glass interaction voxel [2]. In this paper, we introduce a new type of refractive index modification in glasses. It is based on the creation of these photo-induced silver clusters allowing a local change in the refractive index Δn = 5×10-3, which is sufficient for the creation of waveguides and photonics devices. The wave guiding process in our glasses along these structures with original geometry is demonstrated for wavelengths from visible to NIR [3], giving a promising access to integrated optical circuits in these silver containing glasses. Moreover, the characterization of the waveguides is presented, including their original geometry, the refractive index change, the mode profile, the estimation of propagation losses and a comparison with simulation results. 1. K. M. Davis, K. Miura, N. Sugimoto, and K. Hirao, Opt. Lett. 21, 1729-1731 (1996). 2. M. Bellec, A. Royon, K. Bourhis, J. Choi, B. Bousquet, M. Treguer, T. Cardinal, J.-J. Videau, M. Richardson, and L. Canioni, The Journal of Physical Chemistry C 114, 15584-15588 (2010). 3. S. Danto, F. Désévédavy, Y. Petit, J.-C. Desmoulin, A. Abou Khalil, C. Strutynski, M. Dussauze, F

  7. Origin of low δ26Mg basalts with EM-I component: Evidence for interaction between enriched lithosphere and carbonated asthenosphere

    Science.gov (United States)

    Tian, H.; Yang, W.; Li, S. G.; Ke, S.; Chu, Z. Y.

    2016-12-01

    Many studies have focused on the interactions between recycled materials and depleted mantle to explain the origins of EM and HIMU components (e.g., Cohen and O'Nions, 1982; White and Hofmann, 1982). However, little is known about the interactions between recycled materials and enriched mantle and the associated consequences, e.g., late recycled crustal material overprints mantle previously enriched by earlier recycling events of the crust. Recently, light Mg isotopic composition of the basalts from North China Craton (NCC) and South China Block (SCB) has been attributed to recycled carbonate metasomatism from subducted Pacific slab (Yang et al., 2012; Huang et al., 2015). If this explanation is correct, the Cenozoic basalts from Northeast (NE) China should also contain light Mg isotopic compositions. The basalts from NE China have EMI Sr-Nd-Pb isotopic features that are distinct from the NCC and SCB basalts, indicating the contribution of an enriched mantle source (Choi et al., 2006; Chu et al., 2013). Therefore, Mg isotopic compositions of the Cenozoic basalts from NE China will help to determine the interaction between recycled sedimentary carbonates and an enriched mantle. Consistent with the hypothesis, our results show that the Cenozoic basalts from Wudalianchi and Erkeshan, NE China, have homogeneous and light Mg isotopic compositions (δ26Mg =-0.57 to -0.46‰). Based on the similarity to the basalts from NCC and SCB, their light Mg isotopic feature should also be derived from carbonate metasomatism (i.e. carbonated asthenosphere). In addition to that, a question arise that why the interaction between carbonated asthenosphere and the EM-I SLCM significantly modify the trace element and Sr-Nd-Pb isotopic composition of the mantle-derived melt, but have little effect on the Mg isotopes? The possible mechanism is the interaction between low SiO2 melt and peridotite, which converts pyroxene to olivine, as reported in previous studies (e.g., Kelemen et al., 1992

  8. Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

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    Park J

    2013-10-01

    Full Text Available Junsung Park,1,2,* Wonkyung Cho,1,2,* Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Dae-Chul Ha,2,5 Youn-Woong Choi,5 Ha-Young Lee,3 Sun-Hang Cho,5 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Biomaterials Laboratory, Korea Research Institutes of Chemical Technology, Daejeon, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 5Korea United Pharm Inc, Seoul, Republic of Korea *These authors contributed equally to this work Objectives: The purpose of this study was to observe the pharmacokinetic behavior of newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA to be used to coat an iron oxide core to make superparamagnetic iron oxide nanoparticles (SPION. Materials and methods: The isotopes [14C] and [59Fe] were used to label the polymer backbone (CLS and iron oxide core (FLS, respectively. In addition, unradiolabeled cold superparamagnetic iron oxide nanoparticles (SPION/ULS were synthesized to characterize particle size by dynamic light scattering, morphology by transmission electron microscopy, and in vivo magnetic resonance imaging (MRI. CLS and FLS were used separately to investigate the behavior of both the synthesized polymer and [Fe] in Sprague Dawley (SD rats, respectively. Because radioactivity of the isotopes was different by β for CLS and γ for FLS, synthesis of the samples had to be separately prepared. Results: The mean particle size of the ULS was 66.1 nm, and the biodistribution of CLS concentrations in various organs, in rank order of magnitude, was liver > kidney > small intestine > other. The biodistribution of FLS concentrations was liver > spleen > lung > other. These rank orders show that synthesized SPION mainly accumulates in the liver. The differences in the distribution were caused by the SPION metabolism. Radiolabeled

  9. Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards

    Science.gov (United States)

    Ham, H. J.; Lee, S.; Choi, S. H.; Yun, W. S.

    2015-12-01

    Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards Hee Jung Ham1, Seung-Hun Choi1, Woo-Seok Yun1, Sungsu Lee2 1Department of Architectural Engineering, Kangwon National University, Korea 2Division of Civil Engineering, Chungbuk National University, Korea ABSTRACT In this study, fragility functions are developed to estimate expected volcanic ash damages of the agricultural sector in Korea. The fragility functions are derived from two approaches: 1) empirical approach based on field observations of impacts to agriculture from the 2006 eruption of Merapi volcano in Indonesia and 2) the FOSM (first-order second-moment) analytical approach based on distribution and thickness of volcanic ash observed from the 1980 eruption of Mt. Saint Helens and agricultural facility specifications in Korea. Fragility function to each agricultural commodity class is presented by a cumulative distribution function of the generalized extreme value distribution. Different functions are developed to estimate production losses from outdoor and greenhouse farming. Seasonal climate influences vulnerability of each agricultural crop and is found to be a crucial component in determining fragility of agricultural commodities to an ash fall. In the study, the seasonality coefficient is established as a multiplier of fragility function to consider the seasonal vulnerability. Yields of the different agricultural commodities are obtained from Korean Statistical Information Service to create a baseline for future agricultural volcanic loss estimation. Numerically simulated examples of scenario ash fall events at Mt. Baekdu volcano are utilized to illustrate the application of the developed fragility functions. Acknowledgements This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of

  10. Dual-function synthetic peptide derived from BMP4 for highly efficient tumor targeting and antiangiogenesis

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    Choi SH

    2016-09-01

    Full Text Available Suk Hyun Choi,1,* Jue Yeon Lee,2,* Jin Sook Suh,1 Yoon Shin Park,3 Chong Pyoung Chung,2 Yoon Jeong Park1 1Department of Dental Regenerative Biotechnology, Dental Research Institute, 2Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC, School of Dentistry, Seoul National University, Seoul, 3Department in Microbiology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju, South Korea *These authors contributed equally to this work Abstract: Angiogenesis plays a critical role in the growth and metastasis of cancer, and growth factors released from cancer promote blood-vessel formation in the tumor microenvironment. The angiogenesis is accelerated via interactions of growth factors with the high-affinity receptors on cancer cells. In particular, heparan sulfate proteoglycans (HSPGs on the surface of cancer cells have been shown to be important in many aspects of determining a tumor’s phenotype and development. Specifically, the regulation of the interactions between HSPGs and growth factors results in changes in tumor progression. A peptide with heparin-binding (HBP activity has been developed and synthesized to inhibit tumor growth via the prevention of angiogenesis. We hypothesized that HBP could inhibit the interaction of growth factors and HSPGs on the surface of cancer cells, decrease paracrine signaling in endothelial cells (ECs, and finally decrease angiogenesis in the tumor microenvironment. In this study, we found that HBP had antiangiogenic effects in vitro and in vivo. The conditioned media obtained from a breast cancer cell line treated with HBP were used to culture human umbilical vein ECs (HUVECs to evaluate the antiangiogenic effect of HBP on ECs. HBP effectively inhibited the migration, invasion, and tube formation of HUVECs in vitro. In addition, the expressions of angiogenesis-mediating factors, including ERK, FAK, and Akt, were considerably

  11. Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

    Directory of Open Access Journals (Sweden)

    Soni KK

    2016-12-01

    Full Text Available Kiran Kumar Soni,1 Hye Kyung Kim,2 Bo Ram Choi,1 Keshab Kumar Karna,1 Jae Hyung You,1 Jai Seong Cha,1 Yu Seob Shin,1 Sung Won Lee,3 Chul Young Kim,4 Jong Kwan Park1 1Department of Urology, Institute for Medical Sciences, Chonbuk National University Medical School – Biomedical Research and Institute and Clinical Trial Center for Medical Devices, Chonbuk National University Hospital, Jeonju, 2College of Pharmacy, Kyungsung University, Busan, 3Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University Medical School, Seoul, 4College of Pharmacy, Hanyang University, Ansan, Republic of Korea Abstract: Cisplatin (CIS is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts of the body. This study investigated the severity of CIS toxicity by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment groups and control group with CIS (2, 4, 6, 8, and 10 mg/kg administered intraperitoneally for 5 days. The body and organs were weighed, epididymal sperm was counted, and sperm motility and sperm apoptosis were evaluated. Blood samples were evaluated for complete blood count, reactive oxygen and nitrogen species, malondialdehyde levels, and total testosterone. The testicular tissue was examined for steroidogenic acute regulatory protein and endoplasmic reticulum stress protein. Epididymal sperm was collected for CatSper Western blot. The toxic effects of different doses of CIS on the testis and kidney were compared histologically. The weights of body, testis, epididymis, prostate, seminal vesicle, and kidney; sperm count; sperm motility; steroidogenic acute regulatory protein level; and epididymal sperm count were significantly lower in the CIS-treated groups than in the control group. In contrast, sperm apoptosis, plasma reactive oxygen and nitrogen species, and malondialdehyde, testosterone, red blood cell

  12. Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

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    Lee JA

    2014-12-01

    Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

  13. Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

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    Shin D

    2017-01-01

    Full Text Available Dongseong Shin,1 Sook Joung Lee,2 Yu-Mi Ha,3 Young-Sim Choi,3 Jae-Won Kim,3 Se-Rin Park,3 Min Kyu Park3 1Clinical Trials Center, Gachon University Gil Medical Center, Incheon, 2Department of Rehabilitation Medicine, 3Department of Clinical Pharmacology and Therapeutics, Dong-A University College of Medicine and Hospital, Busan, South Korea Objective: Prostaglandin E2 (PGE2 synthesis is modulated by COX2. Changes in PGE2 could be used to quantify the COX2 inhibition after ibuprofen administration. This study investigated the pharmacokinetic and pharmacodynamic relationships for COX2 inhibition according to three formulations of ibuprofen in healthy male subjects.Materials and methods: A randomized, open-label, single-dose, three-treatment, six-sequence crossover study was performed in 36 healthy South Korean male volunteers. Enrolled subjects received the following three 200 mg ibuprofen formulations: ibuprofen arginine, solubilized ibuprofen capsule, and standard ibuprofen. Pharmacokinetic and pharmacodynamic blood samples were collected for 16 hours following treatment. For pharmacodynamic evaluations, lipopolysaccharide (LPS-induced PGE2 inhibition at each time point compared to predose was measured. Noncompartmental analysis was used for pharmacokinetic assessment, and time-weighted average inhibition (WAI of PGE2 was applied to the pharmacodynamic evaluation.Results: After a single oral dose of the ibuprofen formulations, the median times to maximum concentration were 0.42, 0.5, and 1.25 hours in ibuprofen arginine, solubilized ibuprofen capsule, and ibuprofen, respectively. The maximum observed plasma concentration was lower in ibuprofen, and the area under the plasma concentration–time curve was comparable among the three formulations. A significant difference was observed between fast-acting formulations and standard ibuprofen tablets for both maximum concentration and time taken to reach it. Individual formulations had an effect on PGE

  14. Increased fat in pancreas not associated with risk of pancreatitis post-endoscopic retrograde cholangiopancreatography

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    Pokhrel B

    2014-06-01

    Full Text Available Bhupesh Pokhrel,1 Eun Kwang Choi,1 Omer Khalid,2 Kumar Sandrasegaran,3 Evan L Fogel,1 Lee McHenry,1 Stuart Sherman,1 James Watkins,1 Gregory A Cote,1 Henry A Pitt,4 Nicholas J Zyromski,4 Beth Juliar,1 Glen A Lehman11Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 2Department of Gastroenterology, St Louis University School of Medicine, St Louis, MO, 3Department of Radiology, 4Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USABackground: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction. In this study, we aimed to determine if an increased quantity of pancreatic fat is an independent risk factor for pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP.Methods: In this case control study, we retrospectively reviewed a local radiological and ERCP database to identify patients who had had abdominal magnetic resonance imaging (MRI followed by ERCP no more than 60 days later between September 2003 and January 2011. Percentage of fat was determined by recording signal intensity in the in-phase (Sin and out-of-phase (Sout T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout/(Sin × 2 by an abdominal radiologist blinded to clinical history. Controls matched for age, gender, and other pancreatobiliary disease were selected from a group with no post-ERCP pancreatitis (before fat content of the pancreas was analyzed.Results: Forty-seven patients were enrolled. Compared with controls, subjects with post-ERCP pancreatitis were similar in terms of age (41.4 years versus 41.1 years, gender (21.2% versus 20.2% males, pancreatobiliary disease characteristics, and most ERCP techniques. Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.Conclusion: Increased pancreatic fat on MRI criteria is not an independent

  15. EDITORIAL: Welcome to the 2012 volume Welcome to the 2012 volume

    Science.gov (United States)

    Garcia, Ephrahim

    2012-01-01

    articles last year, as well as our authors and contributors for submitting their high quality research. We very much look forward to your further involvement with the journal in 2012. Finally, I would like to extend a huge thank you to our diverse Board of Associate Editors who have devoted their time and energy giving invaluable advice on each submitted article, and have been dedicated ambassadors for SMS. A special welcome to Professor Kwang J Kim who joined the Board a few months ago. Professor D Abbott, University of Adelaide, Australia Professor G Akhras, Royal Military College of Canada, Ontario, Canada Professor C Boller, University of Saarland, Saarbrücken, Germany; Fraunhofer-Institut für Zerstörungsfreie Prüfverfahren, Dresden, Germany Professor Cagnol, École Centrale Paris, France Professor G Carman, University of California-Los Angeles, USA Professor S-B Choi, Inha University, Incheon, Korea Dr S H Choi, NASA Langley Research Center, Hampton, VA, USA Professor A Del Grosso, Università degli Studi di Genova, Italy Professor D Erickson, Cornell University, Ithaca, NY, USA Professor A Flatau, University of Maryland, College Park, USA Professor U Gabbert, Universität Magdeburg, Germany Professor A Güemes, Universidad Politecnica de Madrid, Spain Professor S Gopalakrishnan, Indian Institute of Science, Bangalore, India Professor J Kim, Inha University, Incheon, Korea Professor K J Kim, University of Nevada, Reno, USA Professor S J Kim, Seoul National University, Korea Professor D Lagoudas, Texas A&M University, College Station, USA Professor R Lammering, Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Hamburg, Germany Professor C K Lee, National Taiwan University, Taiwan Professor J Leng, Harbin Institute of Technology, China Professor W Li, University of Wollongong, Australia Professor W H Liao, Chinese University of Hong Kong, China Professor C S Lynch, University of California-Los Angeles, USA Dr S Masri, University of Southern California

  16. Guest Editorial

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    Min Young Chung

    2010-03-01

    Full Text Available This special issue comprises of 10 selected papers from the 3rd International Conference on Ubiquitous Information Management and Communication (ICUIMC 2009. From 358 papers submitted in the conference, 106 papers were selected for presentation. Among them, ten qualified papers have been selected as the papers for this special issue, which deal with state-of-the-art communication technology. Sensor network is vulnerable to hostile environments. Thus, 3 papers focus on security issues in wireless sensor network. Also, energy consumption is an important problem in sensor network, which is considered in this issue: "Environment-based selection method for en-route filtering scheme using fuzzy logic" by Sang Jin Lee, Hae Young Lee, Tae Ho Cho, adopts the fuzzy logic to determine the threshold to filter false reports in wireless sensor networks. "Light weight key renewals for clustered sensor networks" by Gicheol Wang, Seunghae Kim, Daewook Kang, Deokjai Choi and Gihwan Cho, proposed a lightweight key renewal scheme, which removes the compromised nodes by reforming clusters. In a cluster, each member uses a pair-wise key to communicate with its cluster head. "An isolation intrusion detection system for hierarchical wireless sensor networks" by Rung-Ching Chen, Chia-Fen Hsieh and Yung-Fa Huang, discusses types of attacks on wireless sensor networks and how to prevent them, and proposes an isolation table to detect intrusions. "An extended energy consumption analysis of reputation-based trust management schemes of wireless sensor networks" by Riaz Ahmed Shaikh, Young-Koo Lee, Sungyoung Lee, has presented a theoretical and simulation-based energy consumption analysis and evaluated three reputation-based trust management schemes of wireless sensor networks. Two security related papers are presented in application layer and physical layer: "The design of e-traveler’s check with efficiency and mutual authentication" by Chin-Chen Chang and Shih-Chang Chang

  17. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

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    Choi JY

    2016-06-01

    Full Text Available Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, 4Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, 5Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea Background: The chronic bronchitis (CB phenotype has been associated with poor quality of life and an increased risk of disease in patients with COPD. However, little information exists regarding the relationship between the CB phenotype and the COPD assessment test (CAT score. The goal of this study was to reveal the different pattern of CAT scores between CB and non-CB patients. Moreover, we aimed to investigate whether the CB phenotype is an independently associated factor for more symptom and high-risk groups.Methods: Data were obtained from the Korea COPD Subgroup Study cohort recruited from 46 centers in South

  18. Silymarin-loaded solid nanoparticles provide excellent hepatic protection: physicochemical characterization and in vivo evaluation

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    Yang KY

    2013-08-01

    Full Text Available Kwan Yeol Yang,1,* Du Hyeong Hwang,1,* Abid Mehmood Yousaf,2 Dong Wuk Kim,2 Young-Jun Shin,2 Ok-Nam Bae,2 Yong-II Kim,1 Jong Oh Kim,1 Chul Soon Yong,1 Han-Gon Choi2 1College of Pharmacy, Yeungnam University, Dae-Dong, Gyongsan, 2College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Sangnok-gu, Ansan, South Korea *These authors contributed equally to this work Background: The purpose of this study was to develop a novel silymarin-loaded solid nanoparticle system with enhanced oral bioavailability and an ability to provide excellent hepatic protection for poorly water-soluble drugs using Shirasu porous glass (SPG membrane emulsification and a spray-drying technique. Methods: A silymarin-loaded liquid nanoemulsion was formulated by applying the SPG membrane emulsification technique. This was further converted into solid state nanosized particles by the spray-drying technique. The physicochemical characteristics of these nanoparticles were determined by scanning electron microscopy, differential scanning calorimetry, and powder X-ray diffraction. Their dissolution, bioavailability, and hepatoprotective activity in rats were assessed by comparison with a commercially available silymarin-loaded product. Results: Formulation of a silymarin-loaded nanoemulsion, comprising silymarin, castor oil, polyvinylpyrrolidone, Transcutol HP, Tween 80, and water at a weight ratio of 5/3/3/1.25/1.25/100 was accomplished using an SPG membrane emulsification technique at an agitator speed of 700 rpm, a feed pressure of 15 kPa, and a continuous phase temperature of 25°C. This resulted in generation of comparatively uniform emulsion globules with a narrow size distribution. Moreover, the silymarin-loaded solid nanoparticles, containing silymarin/castor oil/polyvinylpyrrolidone/Transcutol HP/Tween 80 at a weight ratio of 5/3/3/1.25/1.25, improved about 1,300-fold drug solubility and retained a mean size of about 210 nm

  19. Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

    Directory of Open Access Journals (Sweden)

    Yousaf AM

    2015-03-01

    Full Text Available Abid Mehmood Yousaf,1 Dong Wuk Kim,1 Yu-Kyoung Oh,2 Chul Soon Yong,3 Jong Oh Kim,3 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 2College of Pharmacy, Seoul National University, Seoul, 3College of Pharmacy, Yeungnam University, Gyongsan, South KoreaBackground: The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate.Methods: The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS, fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder.Results: Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in

  20. Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

    Directory of Open Access Journals (Sweden)

    Kim YW

    2014-02-01

    Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the