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Sample records for sang-woon choi simonetta

  1. Generalized Choi states and 2-distillability of quantum states

    Science.gov (United States)

    Chen, Lin; Tang, Wai-Shing; Yang, Yu

    2018-05-01

    We investigate the distillability of bipartite quantum states in terms of positive and completely positive maps. We construct the so-called generalized Choi states and show that it is distillable when it has negative partial transpose. We convert the distillability problem of 2-copy n× n Werner states into the determination of the positivity of an Hermitian matrix. We obtain several sufficient conditions by which the positivity holds. Further, we investigate the case n=3 by the classification of 2× 3× 3 pure states.

  2. mTOR-inhibitor treatment of metastatic renal cell carcinoma: contribution of Choi and modified Choi criteria assessed in 2D or 3D to evaluate tumor response

    Energy Technology Data Exchange (ETDEWEB)

    Lamuraglia, M. [Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France); Raslan, S.; Penna, R.R.; Wagner, M. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Elaidi, R.; Oudard, S. [APHP, Oncology Unit, Georges-Pompidou Hospital, Paris (France); Escudier, B. [Gustave-Roussy Institute, Medical Oncology Department, Villejuif (France); Slimane, K. [Novartis Pharma, Rueil-Malmaison (France); Lucidarme, O. [Groupe Hospitalier Pitie-Salpetriere, APHP UPMC, Service de Radiologie Polyvalente et Oncologique, Paris Cedex 13 (France); Laboratoire d' Imagerie Biomedicale, Sorbonne Universites, UPMC Univ Paris 06, INSERM, CNRS, Paris (France)

    2016-01-15

    To determine whether 2D or 3D Choi and modified Choi (mChoi) criteria could assess the efficacy of everolimus against metastatic renal cell carcinoma (mRCC). RECIST-1.1, Choi, and mChoi criteria were applied retrospectively to analyse baseline and 2-month contrast-enhanced computed tomography (CECT) images in 48 patients with mRCC enrolled in the everolimus arm of the French randomized double-blind multicentre phase III trial comparing everolimus versus placebo (RECORD-1). The primary endpoint was centrally reviewed progression-free survival (PFS) calculated from the initial RECORD-1 analysis. Mean attenuation was determined for 2D target lesion regions of interest drawn on CECT sections whose largest diameters had been measured, and for the 3D whole target lesion. The median PFS was 5.5 months. The median PFS for everolimus responders defined using 3D mChoi criteria was significantly longer than for non-responders (7.6 versus 5.4 months, respectively), corresponding to a hazard ratio for progression of 0.45 (95 % CI: 0.22-0.92), with respective 1-year survival rates of 31 % and 9 %. No other 2D or 3D imaging criteria at 2 months identified patients who would benefit from everolimus. At 2 months, only 3D mChoi criteria were able to identify mRCC patients with a PFS benefit from everolimus. (orig.)

  3. Small data global solutions for the Camassa–Choi equations

    Science.gov (United States)

    Harrop-Griffiths, Benjamin; Marzuola, Jeremy L.

    2018-05-01

    We consider solutions to the Cauchy problem for an internal-wave model derived by Camassa–Choi (1996 J. Fluid Mech. 313 83–103). This model is a natural generalization of the Benjamin–Ono and intermediate long wave equations for weak transverse effects as in the case of the Kadomtsev–Petviashvili equations for the Korteweg-de Vries equation. For that reason they are often referred to as the KP-ILW or the KP–Benjamin–Ono equations regarding finite or infinite depth respectively. We prove the existence and long-time dynamics of global solutions from small, smooth, spatially localized initial data on . The techniques applied here involve testing by wave packet techniques developed by Ifrim and Tataru in (2015 Nonlinearity 28 2661–75 2016 Bull. Soc. Math. France 144 369–94).

  4. Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently.

    Science.gov (United States)

    Lippmann, Doris; Lehmann, Carsten; Florian, Simone; Barknowitz, Gitte; Haack, Michael; Mewis, Inga; Wiesner, Melanie; Schreiner, Monika; Glatt, Hansruedi; Brigelius-Flohé, Regina; Kipp, Anna P

    2014-06-01

    High consumption of Brassica vegetables is considered to prevent especially colon carcinogenesis. The content and pattern of glucosinolates (GSLs) can highly vary among different Brassica vegetables and may, thus, affect the outcome of Brassica intervention studies. Therefore, we aimed to feed mice with diets containing plant materials of the Brassica vegetables broccoli and pak choi. Further enrichment of the diets by adding GSL extracts allowed us to analyze the impact of different amounts (GSL-poor versus GSL-rich) and different patterns (broccoli versus pak choi) of GSLs on inflammation and tumor development in a model of inflammation-triggered colon carcinogenesis (AOM/DSS model). Serum albumin adducts were analyzed to confirm the up-take and bioactivation of GSLs after feeding the Brassica diets for four weeks. In agreement with their high glucoraphanin content, broccoli diets induced the formation of sulforaphane-lysine adducts. Levels of 1-methoxyindolyl-3-methyl-histidine adducts derived from neoglucobrassicin were the highest in the GSL-rich pak choi group. In the colon, the GSL-rich broccoli and the GSL-rich pak choi diet up-regulated the expression of different sets of typical Nrf2 target genes like Nqo1, Gstm1, Srxn1, and GPx2. GSL-rich pak choi induced the AhR target gene Cyp1a1 but did not affect Ugt1a1 expression. Both colitis and tumor number were drastically reduced after feeding the GSL-rich pak choi diet while the other three diets had no effect. GSLs can act anti-inflammatory and anti-carcinogenic but both effects depend on the specific amount and pattern of GSLs within a vegetable. Thus, a high Brassica consumption cannot be generally considered to be cancer-preventive.

  5. Stereoselective uptake and distribution of the chiral neonicotinoid insecticide, Paichongding, in Chinese pak choi (Brassica campestris ssp. chinenesis)

    International Nuclear Information System (INIS)

    Wang, Haiyan; Yang, Zhen; Liu, Ruyang; Fu, Qiuguo; Zhang, Sufen; Cai, Zhiqiang; Li, Juying; Zhao, Xiaojun; Ye, Qingfu; Wang, Wei; Li, Zhong

    2013-01-01

    Highlights: • Absorption of foliar applied Paichongding by pak choi was not stereoselective. • Foliar uptake and downward transport of Paichongding were both found in pak choi. • Enantioselective and epimer-selective root uptake were observed for Paichongding. • Foliage/root uptake showed diastereoselective transport of Paichongding epimers. • The SR and RS are more easily taken up by roots and accumulated in edible parts. -- Abstract: Neonicotinoid chiral insecticidal Paichongding is a promising substitute for the widely used imidacloprid. Four stereoisomers of Paichongding, 5R,7R, 5S,7S, 5S,7R and 5R,7S, were employed in both foliage and roots of Chinese pak choi to investigate their stereoselective uptake and distribution in pak choi. Results showed that after foliar application, no stereoselective absorption into pak-choi plants was observed among the enantiomers. Total absorptions were 35.40% of the applied amount for 5R,7R, 36.66% for 5S,7S, 36.80% for 5S,7R and 38.20% for 5R,7S at 96 HAT. The translocation of the four absorbed stereoisomers within pak choi occurred both acropetally and basipetally and the transport of 14 C from enantiomers 5R,7R and 5S,7S were significantly higher than for 5R,7S and 5S,7R. Significant stereoselective translocation inside plants was observed between Paichongding epimers. Total root uptake reached 16.49–19.85% for 5R,7R and 5S,7S, and 24.57–28.82% for 5S,7R and 5R,7S at 144 HAT. Both enantioselective and diastereoselective root uptake into pak-choi occurred between the four stereoisomers. The 5R,7S and 5S,7R enantiomers were more readily uptaken by the roots than 5R,7R and 5S,7S and accumulated in the edible leaves. These results will help to develop an understanding of Paichongding using only the target-active enantiomer of pesticides

  6. Stereoselective uptake and distribution of the chiral neonicotinoid insecticide, Paichongding, in Chinese pak choi (Brassica campestris ssp. chinenesis)

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Haiyan; Yang, Zhen; Liu, Ruyang; Fu, Qiuguo; Zhang, Sufen; Cai, Zhiqiang; Li, Juying; Zhao, Xiaojun [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Ye, Qingfu, E-mail: qfye@zju.edu.cn [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Wang, Wei [Institute of Nuclear Agricultural Sciences, Key Laboratory of Nuclear Agricultural Sciences of Ministry of Agriculture and Zhejiang Province, Zhejiang University, Hangzhou 310029 (China); Li, Zhong, E-mail: lizhong@ecust.edu.cn [School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237 (China)

    2013-11-15

    Highlights: • Absorption of foliar applied Paichongding by pak choi was not stereoselective. • Foliar uptake and downward transport of Paichongding were both found in pak choi. • Enantioselective and epimer-selective root uptake were observed for Paichongding. • Foliage/root uptake showed diastereoselective transport of Paichongding epimers. • The SR and RS are more easily taken up by roots and accumulated in edible parts. -- Abstract: Neonicotinoid chiral insecticidal Paichongding is a promising substitute for the widely used imidacloprid. Four stereoisomers of Paichongding, 5R,7R, 5S,7S, 5S,7R and 5R,7S, were employed in both foliage and roots of Chinese pak choi to investigate their stereoselective uptake and distribution in pak choi. Results showed that after foliar application, no stereoselective absorption into pak-choi plants was observed among the enantiomers. Total absorptions were 35.40% of the applied amount for 5R,7R, 36.66% for 5S,7S, 36.80% for 5S,7R and 38.20% for 5R,7S at 96 HAT. The translocation of the four absorbed stereoisomers within pak choi occurred both acropetally and basipetally and the transport of {sup 14}C from enantiomers 5R,7R and 5S,7S were significantly higher than for 5R,7S and 5S,7R. Significant stereoselective translocation inside plants was observed between Paichongding epimers. Total root uptake reached 16.49–19.85% for 5R,7R and 5S,7S, and 24.57–28.82% for 5S,7R and 5R,7S at 144 HAT. Both enantioselective and diastereoselective root uptake into pak-choi occurred between the four stereoisomers. The 5R,7S and 5S,7R enantiomers were more readily uptaken by the roots than 5R,7R and 5S,7S and accumulated in the edible leaves. These results will help to develop an understanding of Paichongding using only the target-active enantiomer of pesticides.

  7. Stereoselective uptake and distribution of chiral neoniconoid insecticide paichongding in chinese pak choi (Brassica campestris ssp. Chinenesis)

    International Nuclear Information System (INIS)

    Wang Haiyan; Yang Zhen; Liu Ruyang; Fu Qiuguo; Zhang Sufen; Li Juying; Zhao Xiaojun; Ye Qingfu; Wang Wei; Li Zhong

    2014-01-01

    Paichongding, a neonicotinoid chiral insecticide containing two chiral centers, is a promising substitute for the widely used imidacloprid because it is effective against many imidacloprid-resistant insects. In this study, four optically-pure stereoisomers of Paichongding with 5R, 7R, 5S, 7S, 5S, 7R, and 5R, 7S were employed in both foliar and root of Chinese pak choi to investigate the stereoselective uptake and distribution of the insecticide in pak choi. The results showed, after foliar application, total absorption of individual "1"4C-Paichongding stereoisomers into pak-choi plants demonstrated no stereoselectivity between the enantiomers. The translocation of the four absorbed stereoisomers within pak choi occurred in both acropetal and basipetal directions and the transport of "1"4C from enantiomers 5R, 7R and 5S, 7S were significantly higher than enantiomers 5R, 7S and 5S, 7R. The statistically significant stereoselective translocation inside plants was observed between Paichongding epimers. Root treatment revealed that enantioselective and diastereoselective root uptake into pak-choi plants were both found between the four enantiomers. The enantiomers of 5R, 7S and 5S, 7R were more readily taken up by roots, and more readily accumulated in edible leaves than 5R, 7R and 5S, 7S. These results will help to develop an understanding of the proper application of Paichongding isomers in vegetables, and give useful information for food and environmental assessments of chiral pesticides. (authors)

  8. Isolation and Functional Characterization of a Floral Repressor, BcMAF1, From Pak-choi (Brassica rapa ssp. Chinensis).

    Science.gov (United States)

    Huang, Feiyi; Liu, Tongkun; Hou, Xilin

    2018-01-01

    MADS-box genes form a large gene family in plants and are involved in multiple biological processes, such as flowering. However, the regulation mechanism of MADS-box genes in flowering remains unresolved, especially under short-term cold conditions. In the present study, we isolated BcMAF1 , a Pak-choi ( Brassica rapa ssp. Chinensis ) MADS AFFECTING FLOWERING ( MAF ), as a floral repressor and functionally characterized BcMAF1 in Arabidopsis and Pak-choi. Subcellular localization and sequence analysis indicated that BcMAF1 was a nuclear protein and contained a conserved MADS-box domain. Expression analysis revealed that BcMAF1 had higher expression levels in leaves, stems, and petals, and could be induced by short-term cold conditions in Pak-choi. Overexpressing BcMAF1 in Arabidopsis showed that BcMAF1 had a negative function in regulating flowering, which was further confirmed by silencing endogenous BcMAF1 in Pak-choi. In addition, qPCR results showed that AtAP3 expression was reduced and AtMAF2 expression was induced in BcMAF1 -overexpressing Arabidopsis . Meanwhile, BcAP3 transcript was up-regulated and BcMAF2 transcript was down-regulated in BcMAF1 -silencing Pak-choi. Yeast one-hybrid and dual luciferase transient assays showed that BcMAF1 could bind to the promoters of BcAP3 and BcMAF2 . These results indicated that BcAP3 and BcMAF2 might be the targets of BcMAF1. Taken together, our results suggested that BcMAF1 could negatively regulate flowering by directly activating BcMAF2 and repressing BcAP3 .

  9. Cultivar-Specific Changes in Primary and Secondary Metabolites in Pak Choi (Brassica Rapa, Chinensis Group by Methyl Jasmonate

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    Moo Jung Kim

    2017-05-01

    Full Text Available Glucosinolates, their hydrolysis products and primary metabolites were analyzed in five pak choi cultivars to determine the effect of methyl jasmonate (MeJA on metabolite flux from primary metabolites to glucosinolates and their hydrolysis products. Among detected glucosinolates (total 14 glucosinolates; 9 aliphatic, 4 indole and 1 aromatic glucosinolates, indole glucosinolate concentrations (153–229% and their hydrolysis products increased with MeJA treatment. Changes in the total isothiocyanates by MeJA were associated with epithiospecifier protein activity estimated as nitrile formation. Goitrin, a goitrogenic compound, significantly decreased by MeJA treatment in all cultivars. Changes in glucosinolates, especially aliphatic, significantly differed among cultivars. Primary metabolites including amino acids, organic acids and sugars also changed with MeJA treatment in a cultivar-specific manner. A decreased sugar level suggests that they might be a carbon source for secondary metabolite biosynthesis in MeJA-treated pak choi. The result of the present study suggests that MeJA can be an effective agent to elevate indole glucosinolates and their hydrolysis products and to reduce a goitrogenic compound in pak choi. The total glucosinolate concentration was the highest in “Chinese cabbage” in the control group (32.5 µmol/g DW, but indole glucosinolates increased the greatest in “Asian” when treated with MeJA.

  10. Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, N., E-mail: Nicolai.schramm@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Englhart, E., E-mail: Elisabeth.Englhart@gmx.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Schlemmer, M., E-mail: Marcus.Schlemmer@med.uni-muenchen.de [Department of Medicine III, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Hittinger, M., E-mail: Markus.Hittinger@uksh.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Übleis, C., E-mail: Christopher.Uebleis@med.uni-muenchen.de [Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Becker, C.R., E-mail: Christoph.becker@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Reiser, M.F., E-mail: Maximilian.Reiser@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Berger, F., E-mail: Frank.Berger@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany)

    2013-06-15

    Purpose: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). Patients and methods: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan–Meier statistics. Results: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. Conclusion: One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.

  11. Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria

    International Nuclear Information System (INIS)

    Schramm, N.; Englhart, E.; Schlemmer, M.; Hittinger, M.; Übleis, C.; Becker, C.R.; Reiser, M.F.; Berger, F.

    2013-01-01

    Purpose: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). Patients and methods: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan–Meier statistics. Results: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. Conclusion: One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated

  12. Análise de crescimento e produtividade do pak choi cultivado sob diferentes doses de nitrogênio

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    Janaína Dartora

    2013-08-01

    Full Text Available O objetivo deste trabalho foi avaliar a influência de diferentes doses de nitrogênio no crescimento e produtividade do pak choi. O experimento foi conduzido, em cultivo protegido, de outubro a novembro de 2007, em Marechal Cândido Rondon, PR. O delineamento experimental foi de blocos casualizados, com cinco tratamentos (0, 60, 105, 150 e 195 kg ha-1 de N e quatro repetições. O nitrogênio foi aplicado em três diferentes épocas (transplantio, 7 e 14 dias após o transplantio. Foram realizadas cinco coletas das plantas, semanalmente, avaliando-se a produção de massa da matéria seca e área foliar, para obtenção das taxas de crescimento absoluto e relativo, taxa assimilatória líquida, razão de área foliar e área foliar específica. Na colheita, foram avaliados altura da planta, diâmetro e matéria fresca da parte aérea e produtividade. Incrementos na adubação nitrogenada até a dose de 195 kg ha-1 proporcionam incrementos no crescimento e produtividade do pak choi.

  13. Comparing the influence of selenite (Se4+) and selenate (Se6+) on the inhibition of the mercury (Hg) phytotoxicity to pak choi.

    Science.gov (United States)

    Tran, Thi Anh Thu; Dinh, Quang Toan; Cui, Zeiwei; Huang, Jie; Wang, Dan; Wei, Tianjiao; Liang, Dongli; Sun, Xin; Ning, Ping

    2018-01-01

    Selenite (Se (IV)) and selenate (Se (IV)) have recently been demonstrated to be equally effective in inhibiting mercury (Hg) phytotoxicity to plants. This assertion is still unclear. In this study, we aimed to explore the potential effects of Se species (Se 4+ and Se 6+ ) on the inhibition of the mercury (Hg) bioavailability to pak choi in dry land. Pot experiments with exposure to different dosages of mercuric chloride (HgCl 2 ) and selenite (Na 2 SeO 3 ) or selenate (Na 2 SeO 4 ) were treated. To compare the influence of Se (IV) and Se (VI) on the bioaccumulation and bioavailability of Hg, the levels of total Hg in different pak choi (Brassica chinensis L.) tissues (roots and shoots) and the distribution changes of Hg fractions in soil before planting and after harvest were determined as well as the Hg I R values in soils (relative binding intensity) were analyzed. Results showed that application Se (IV) reduced the concentrations of Hg in pak choi roots more than Se (VI). Hg concentrations were also decreased in pak choi shoots in Se (IV) treatments, while which notably increased in Se (VI) treatments. Thus, Se (IV) plays a more important role than Se (VI) in limiting the absorption and bioaccumulation of Hg in pak choi. Moreover, this inhibition may only significantly occur when Se (IV) is at an appropriate level (2.5mg/kg). In addition, the good correlations between the proportions of mobile Hg fractions (soluble and exchangeable fractions), I R values with the Hg concentrations in plants were observed. This affirmed the importance of the Hg fractions transformation and the I R indicator of Hg in the assessment of their bioavailability. Our findings regarding the importance of Se (IV) influence in reducing Hg bioaccumulation not only provided the correct appraisal about the effect of Se species on the inhibition of the Hg phytotoxicity to pak choi in dry land, but also be a good reference for selecting Se fertilizer forms (Se 4+ or Se 6+ ). Copyright © 2017

  14. Opening end-of-life discussions: how to introduce Voicing My CHOiCES™, an advance care planning guide for adolescents and young adults.

    Science.gov (United States)

    Zadeh, Sima; Pao, Maryland; Wiener, Lori

    2015-06-01

    Each year, more than 11,000 adolescents and young adults (AYAs), aged 15-34, die from cancer and other life-threatening conditions. In order to facilitate the transition from curative to end-of-life (EoL) care, it is recommended that EoL discussions be routine, begin close to the time of diagnosis, and continue throughout the illness trajectory. However, due largely to discomfort with the topic of EoL and how to approach the conversation, healthcare providers have largely avoided these discussions. We conducted a two-phase study through the National Cancer Institute with AYAs living with cancer or pediatric HIV to assess AYA interest in EoL planning and to determine in which aspects of EoL planning AYAs wanted to participate. These results provided insight regarding what EoL concepts were important to AYAs, as well as preferences in terms of content, design, format, and style. The findings from this research led to the development of an age-appropriate advance care planning guide, Voicing My CHOiCES™. Voicing My CHOiCES™: An Advanced Care Planning Guide for AYA became available in November 2012. This manuscript provides guidelines on how to introduce and utilize an advance care planning guide for AYAs and discusses potential barriers. Successful use of Voicing My CHOiCES™ will depend on the comfort and skills of the healthcare provider. The present paper is intended to introduce the guide to providers who may utilize it as a resource in their practice, including physicians, nurses, social workers, chaplains, psychiatrists, and psychologists. We suggest guidelines on how to: incorporate EoL planning into the practice setting, identify timepoints at which a patient's goals of care are discussed, and address how to empower the patient and incorporate the family in EoL planning. Recommendations for introducing Voicing My CHOiCES™ and on how to work through each section alongside the patient are provided.

  15. Molecular evolution, characterization and expression analysis of SnRK2 gene family in Pak-choi (Brassica rapa ssp. chinensis

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    Zhinan eHuang

    2015-10-01

    Full Text Available Abstract: The sucrose non-fermenting 1-related protein kinase 2 (SnRK2 family members are plant-specific serine/threonine kinases that are involved in the plant response to abiotic stress and abscisic acid (ABA-dependent plant development. Further understanding of the evolutionary history and expression characteristics of these genes will help to elucidate the mechanisms of the stress tolerance in Pak-choi, an important green leafy vegetable in China. Thus, we investigated the evolutionary patterns, footprints and conservation of SnRK2 genes in selected plants and later cloned and analyzed SnRK2 genes in Pak-choi. We found that this gene family was preferentially retained in Brassicas after the Brassica-Arabidopsis thaliana split. Next, we cloned and sequenced 13 SnRK2 from both cDNA and DNA libraries of stress-induced Pak-choi, which were under conditions of ABA, salinity, cold, heat, and osmotic treatments. Most of the BcSnRK2s have eight exons and could be divided into three groups. The subcellular localization predictions suggested that the putative BcSnRK2 proteins were enriched in the nucleus. The results of an analysis of the expression patterns of the BcSnRK2 genes showed that BcSnRK2 group III genes were robustly induced by ABA treatments. Most of the BcSnRK2 genes were activated by low temperature, and the BcSnRK2.6 genes responded to both ABA and low temperature. In fact, most of the BcSnRK2 genes showed positive or negative regulation under ABA and low temperature treatments, suggesting that they may be global regulators that function at the intersection of multiple signaling pathways to play important roles in Pak-choi stress responses.

  16. Phytoavailability of cadmium (Cd) to Pak choi (Brassica chinensis L.) grown in Chinese soils: a model to evaluate the impact of soil Cd pollution on potential dietary toxicity.

    Science.gov (United States)

    Rafiq, Muhammad Tariq; Aziz, Rukhsanda; Yang, Xiaoe; Xiao, Wendan; Stoffella, Peter J; Saghir, Aamir; Azam, Muhammad; Li, Tingqiang

    2014-01-01

    Food chain contamination by soil cadmium (Cd) through vegetable consumption poses a threat to human health. Therefore, an understanding is needed on the relationship between the phytoavailability of Cd in soils and its uptake in edible tissues of vegetables. The purpose of this study was to establish soil Cd thresholds of representative Chinese soils based on dietary toxicity to humans and develop a model to evaluate the phytoavailability of Cd to Pak choi (Brassica chinensis L.) based on soil properties. Mehlich-3 extractable Cd thresholds were more suitable for Stagnic Anthrosols, Calcareous, Ustic Cambosols, Typic Haplustalfs, Udic Ferrisols and Periudic Argosols with values of 0.30, 0.25, 0.18, 0.16, 0.15 and 0.03 mg kg-1, respectively, while total Cd is adequate threshold for Mollisols with a value of 0.86 mg kg-1. A stepwise regression model indicated that Cd phytoavailability to Pak choi was significantly influenced by soil pH, organic matter, total Zinc and Cd concentrations in soil. Therefore, since Cd accumulation in Pak choi varied with soil characteristics, they should be considered while assessing the environmental quality of soils to ensure the hygienically safe food production.

  17. Phytoavailability of Cadmium (Cd) to Pak Choi (Brassica chinensis L.) Grown in Chinese Soils: A Model to Evaluate the Impact of Soil Cd Pollution on Potential Dietary Toxicity

    Science.gov (United States)

    Yang, Xiaoe; Xiao, Wendan; Stoffella, Peter J.; Saghir, Aamir; Azam, Muhammad; Li, Tingqiang

    2014-01-01

    Food chain contamination by soil cadmium (Cd) through vegetable consumption poses a threat to human health. Therefore, an understanding is needed on the relationship between the phytoavailability of Cd in soils and its uptake in edible tissues of vegetables. The purpose of this study was to establish soil Cd thresholds of representative Chinese soils based on dietary toxicity to humans and develop a model to evaluate the phytoavailability of Cd to Pak choi (Brassica chinensis L.) based on soil properties. Mehlich-3 extractable Cd thresholds were more suitable for Stagnic Anthrosols, Calcareous, Ustic Cambosols, Typic Haplustalfs, Udic Ferrisols and Periudic Argosols with values of 0.30, 0.25, 0.18, 0.16, 0.15 and 0.03 mg kg−1, respectively, while total Cd is adequate threshold for Mollisols with a value of 0.86 mg kg−1. A stepwise regression model indicated that Cd phytoavailability to Pak choi was significantly influenced by soil pH, organic matter, total Zinc and Cd concentrations in soil. Therefore, since Cd accumulation in Pak choi varied with soil characteristics, they should be considered while assessing the environmental quality of soils to ensure the hygienically safe food production. PMID:25386790

  18. Glutamine nitrogen and ammonium nitrogen supplied as a nitrogen source is not converted into nitrate nitrogen of plant tissues of hydroponically grown pak-choi (Brassica chinensis L.).

    Science.gov (United States)

    Wang, H-J; Wu, L-H; Tao, Q-N; Miller, D D; Welch, R M

    2009-03-01

    Many vegetables, especially leafy vegetables, accumulate NO(-) (3)-N in their edible portions. High nitrate levels in vegetables constitute a health hazard, such as cancers and blue baby syndrome. The aim of this study was to determine if (1) ammonium nitrogen (NH(+) (4)-N) and glutamine-nitrogen (Gln-N) absorbed by plant roots is converted into nitrate-nitrogen of pak-choi (Brassica chinensis L.) tissues, and (2) if nitrate-nitrogen (NO(-) (3)-N) accumulation and concentration of pak-choi tissues linearly increase with increasing NO(-) (3)-N supply when grown in nutrient solution. In experiment 1, 4 different nitrogen treatments (no nitrogen, NH(+) (4)-N, Gln-N, and NO(-) (3)-N) with equal total N concentrations in treatments with added N were applied under sterile nutrient medium culture conditions. In experiment 2, 5 concentrations of N (from 0 to 48 mM), supplied as NO(-) (3)-N in the nutrient solution, were tested. The results showed that Gln-N and NH(+) (4)-N added to the nutrient media were not converted into nitrate-nitrogen of plant tissues. Also, NO(-) (3)-N accumulation in the pak-choi tissues was the highest when plants were supplied 24 mM NO(-) (3)-N in the media. The NO(-) (3)-N concentration in plant tissues was quadratically correlated to the NO(-) (3)-N concentration supplied in the nutrient solution.

  19. Phytoavailability of cadmium (Cd to Pak choi (Brassica chinensis L. grown in Chinese soils: a model to evaluate the impact of soil Cd pollution on potential dietary toxicity.

    Directory of Open Access Journals (Sweden)

    Muhammad Tariq Rafiq

    Full Text Available Food chain contamination by soil cadmium (Cd through vegetable consumption poses a threat to human health. Therefore, an understanding is needed on the relationship between the phytoavailability of Cd in soils and its uptake in edible tissues of vegetables. The purpose of this study was to establish soil Cd thresholds of representative Chinese soils based on dietary toxicity to humans and develop a model to evaluate the phytoavailability of Cd to Pak choi (Brassica chinensis L. based on soil properties. Mehlich-3 extractable Cd thresholds were more suitable for Stagnic Anthrosols, Calcareous, Ustic Cambosols, Typic Haplustalfs, Udic Ferrisols and Periudic Argosols with values of 0.30, 0.25, 0.18, 0.16, 0.15 and 0.03 mg kg-1, respectively, while total Cd is adequate threshold for Mollisols with a value of 0.86 mg kg-1. A stepwise regression model indicated that Cd phytoavailability to Pak choi was significantly influenced by soil pH, organic matter, total Zinc and Cd concentrations in soil. Therefore, since Cd accumulation in Pak choi varied with soil characteristics, they should be considered while assessing the environmental quality of soils to ensure the hygienically safe food production.

  20. Induced Production of 1-Methoxy-indol-3-ylmethyl Glucosinolate by Jasmonic Acid and Methyl Jasmonate in Sprouts and Leaves of Pak Choi (Brassica rapa ssp. chinensis

    Directory of Open Access Journals (Sweden)

    Hansruedi Glatt

    2013-07-01

    Full Text Available Pak choi plants (Brassica rapa ssp. chinensis were treated with different signaling molecules methyl jasmonate, jasmonic acid, linolenic acid, and methyl salicylate and were analyzed for specific changes in their glucosinolate profile. Glucosinolate levels were quantified using HPLC-DAD-UV, with focus on induction of indole glucosinolates and special emphasis on 1-methoxy-indol-3-ylmethyl glucosinolate. Furthermore, the effects of the different signaling molecules on indole glucosinolate accumulation were analyzed on the level of gene expression using semi-quantitative realtime RT-PCR of selected genes. The treatments with signaling molecules were performed on sprouts and mature leaves to determine ontogenetic differences in glucosinolate accumulation and related gene expression. The highest increase of indole glucosinolate levels, with considerable enhancement of the 1-methoxy-indol-3-ylmethyl glucosinolate content, was achieved with treatments of sprouts and mature leaves with methyl jasmonate and jasmonic acid. This increase was accompanied by increased expression of genes putatively involved in the indole glucosinolate biosynthetic pathway. The high levels of indole glucosinolates enabled the plant to preferentially produce the respective breakdown products after tissue damage. Thus, pak choi plants treated with methyl jasmonate or jasmonic acid, are a valuable tool to analyze the specific protection functions of 1-methoxy-indole-3-carbinole in the plants defense strategy in the future.

  1. Injury survey in Choi Kwang Do (CKD) martial art practitioners around the world: CKD is a safe form of training for adults.

    Science.gov (United States)

    Jee, Yong-Seok; Eun, Denny

    2018-02-01

    Among the many sports and activities to choose from, martial arts are becoming increasingly popular for health and fitness. Due to the different nature of the various styles of martial arts, injuries are not uncommon. Though there have been studies on the injury rates of several martial art styles, there have been none regarding Choi Kwang Do (CKD), a noncompetitive martial art with relaxed and fluid movements designed to promote health and fitness for people of all ages. The purpose of this study was to examine the rate of injury for adults training in CKD to find out whether this is a safe style of martial art for adults. This study found the prevalence, causes, severity, and types of injuries from CKD practitioners around the world through an online survey targeting adults (n=122), aged 18 or older, with varying years of training experience. The annual rate of injury was 11.73 for every 100 CKD practitioners. There was no correlation between the length of training experience and injury. Training frequency and duration had no significant relationship with injury rates. A significant positive relationship between training intensity and injury existed ( P =0.009). The results of the study found that CKD can be an attractive option for adults of any age who are looking to learn a martial art or choose a physical activity with a low risk of injury, however the training intensity should be kept at a level that is not excessively high.

  2. Identification of flavonoids and hydroxycinnamic acids in pak choi varieties (Brassica campestris L. ssp. chinensis var. communis) by HPLC-ESI-MSn and NMR and their quantification by HPLC-DAD.

    Science.gov (United States)

    Harbaum, Britta; Hubbermann, Eva Maria; Wolff, Christian; Herges, Rainer; Zhu, Zhujun; Schwarz, Karin

    2007-10-03

    Twenty-eight polyphenols (11 flavonoid derivatives and 17 hydroxycinnamic acid derivatives) were detected in different cultivars of the Chinese cabbage pak choi ( Brassica campestris L. ssp. chinensis var. communis) by HPLC-DAD-ESI-MS(n). Kaempferol was found to be the major flavonoid in pak choi, glycosylated and acylated with different compounds. Smaller amounts of isorhamnetin were also detected. A structural determination was carried out by (1)H and (13)C NMR spectroscopy for the main compound, kaempferol-3-O-hydroxyferuloylsophoroside-7-O-glucoside, for the first time. Hydroxycinnamic acid derivatives were identified as different esters of quinic acid, glycosides, and malic acid. The latter ones are described for the first time in cabbages. The content of polyphenols was determined in 11 cultivars of pak choi, with higher concentrations present in the leaf blade than in the leaf stem. Hydroxycinnamic acid esters, particularly malic acid derivatives, are present in both the leaf blade and leaf stem, whereas flavonoid levels were determined only in the leaf blade.

  3. Impact of different feedstocks derived biochar amendment with cadmium low uptake affinity cultivar of pak choi (Brassica rapa ssb. chinensis L.) on phytoavoidation of Cd to reduce potential dietary toxicity.

    Science.gov (United States)

    Yasmin Khan, Kiran; Ali, Barkat; Cui, Xiaoqiang; Feng, Ying; Yang, Xiaoe; Joseph Stoffella, Peter

    2017-07-01

    Biochar has become eco-friendly amendment used for phytoavoidation with low cadmium (Cd) accumulating cultivars of crops to ensure food safety in Cd contaminated soils. In this study, biochar with different waste feedstock material were evaluated for their effectiveness on essential trace metals mobility, Cd bioavailability and its accumulation in two contrasting Cd accumulating cultivars of pak choi (Brassica rapa ssp. chinensis L.) grown in Cd contaminated Mollisol soil. A greenhouse experiment was conducted with plants grown in Cd contaminated soil that had been amended with biochar derived from barley straw, tomato green waste, chicken manure, duck manure and swine manure at application rate of 0%, 2.5% and 5.0% (w/w). The results showed that soil pH was significantly increased by all treatments. Biochar increased plant dry biomass, micronutrients bioavailability with significant differences in the Cd sorption capacity, with the effectiveness higher with increasing biochar application rate. However, tomato green waste (TGW) and chicken manure (CM) derived biochar were more effective than the other biochar in reducing Cd mobilization in soil by 35-54% and 26-43% and reduced its accumulation in shoots of pak choi cultivars by 34-76% and 33-72% in low Cd accumulator cultivar and 64-85% and 55-80% in high Cd accumulator cultivar than the control. Overall, results indicate that TGW and CM biochar can efficiently immobilize Cd, thereby reducing bioavailability in Cd contaminated Mollisol soil to ensure food safety. Copyright © 2017 Elsevier Inc. All rights reserved.

  4. Antiproliferation effects of selected Tanzania plants | Choi | African ...

    African Journals Online (AJOL)

    Background: Plants still remain a prime source of drugs for the treatment of cancer and can provide leads for the development of novel anticancer agents. Our screening of indigenous medicinal plants from Tanzania has led to the identification of the number of anticancer activity. Material and methods: The current study ...

  5. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Reynolds, A

    2016-03-01

    Our aim was to establish the feeding history, presentation, management and rate of resolution for an Irish cohort of children with cow’s milk protein allergy (CMPA) attending a hospital-based outpatient service. This was a cohort study consisting of two parts: a retrospective chart review and a follow-up questionnaire. Fifty-one infants (male: 61%, n=31) were enrolled. Twenty-one (41%) had IgE-mediated allergy. Twenty-nine (57%) had non-IgE mediated allergy. Twenty-two (49%) had tried ≥3 different formulas prior to diagnosis. Of the children who had reached two years, the overall rate of tolerance was 53% (IgE: 35%, non-IgE: 67%). Mild cases of CMPA can be managed in the community. Potential severe complications include faltering growth and anaphylaxis. CMPA should be managed using a multi-disciplinary approach. Increased awareness of CMPA may speed diagnosis and decrease the use of inappropriate formulas.

  6. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Yadav, B L

    2015-04-07

    Social skills training, a psychological approach, is used to ameliorate the deficits in social skills among patients with a severe mental illness. For the efficacy of social skills training in schizophrenia, the literature in other core psychiatric disciplines (i.e. psychology, psychiatry, etc) indicates some conflicting evidences and a limited quality of evidence in psychiatric nursing. With the exemption of a few individual nursing studies, no systematic review is available to date in psychiatric nursing literature. This systematic review of literature was undertaken to explore the efficacy of social skills training in schizophrenia.

  7. Aras Chois Fharraige, Pairc, An Spidéal, Galway.

    LENUS (Irish Health Repository)

    Gouda, Pishoy

    2015-12-01

    To provide the optimum level of healthcare, it is important that the supply of well-trained doctors meets the demand. However, despite many initiatives, Ireland continues to have a shortfall of physicians, which has been projected to persist. Our study aimed to investigate the migration intentions of Irish medical students and identify the factors that influence their decisions in order to design appropriate interventions to sustain the supply of trained doctors in order to maintain a viable medical system.

  8. ANALYSIS OF EXISTING SCHEMES AND THE OPTIMIZING SETTLEMENT CHOIS OF PILES WORK SCHEMES IN CLAY SOILS

    Directory of Open Access Journals (Sweden)

    BOLSHAKOV V. I.

    2016-09-01

    Full Text Available Summary. It were considered and analyzed the existing schemes of piles work in clay soils. 1. Leningrad scientific school, where the formation of pile bearing capacity use as the basis of the thixotropic clay soils hardening and radial soil pressing around the pile shaft during the piles driving with pile-driving equipment for the exploitation period. 2. Odessa scientific school, in which the uplift soil formation from the edge pile use as the basis of the pile bearing capacity during the piles driving, the formation of the pressed zones (platform in the piles edge plane, the gap formation around the pile shaft during its diving by ground pushed moving with the pile edge. 3. Preconditions of the pile bearing capacity formation of the pile by the thixotropic soil hardening in time and the radial soil pressing around the pile shaft can not give an answer to the following questions: 1 Why during the pile driving is formed the gap around the trunk of dived piles, when by condition there is a radial soil hardening around the trunk? 2 Why in the interpiled space is formed the lune (deflection, not the soil mass swelling (due to the radial hardening? 3 By what is formed the calculated soil resistance under the lower end (edge of the pile? which is about 10 times higher than the calculated soil resistance in the edge plane, according to the Building Code V.2.1-10. 2009? The justified answers on all these and other technical and technological matters give perquisites of the Odessa scientific school with additions and authors developments

  9. Single seed NIR as a fast method to predict germination ability in Pak Choi

    DEFF Research Database (Denmark)

    Gislum, René; Deleuran, Lise Christina; Olesen, Merete Halkjær

    2012-01-01

    Single seed NIR has further been tested to determine the applicability for prediction of seed viability in radish (Raphanus sativus L.) seeds and spinach (Spinacia oleracea L.) seeds. The studies show the possibility of using NIR spectroscopy in a seed separating process in the future, provided...

  10. Compensatory structural and functional adaptation after radical nephrectomy for renal cell carcinoma according to preoperative stage of chronic kidney disease. Choi DK, Jung SB, Park BH, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Jeon HG.J Urol. 2015 Oct;194(4):910-5. [Epub 2015 Apr 28]. doi: 10.1016/j.juro.2015.04.093.

    Science.gov (United States)

    Jay, Raman; Jung, S B; Park, B H; Jeong, B C; Seo, S I; Jeon, S S; Lee, H M; Choi, H Y; Jeon, H G

    2017-03-01

    We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage. We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1.73m 2 or greater (230, 42.4%), chronic kidney disease stage II-glomerular filtration rate 60 to less than 90ml/min/1.73m 2 (227, 41.8%), and chronic kidney disease stage III-glomerular filtration rate 30 to less than 60ml/min/1.73m 2 (86, 15.8%). Computerized tomography performed within 2 months before surgery and 1 year after surgery was used to assess functional renal volume for measuring the degree of hypertrophy of the remnant kidney, and the preoperative and postoperative glomerular filtration rate per unit volume of functional renal volume was used to calculate the degree of hyperfiltration. Among all patients (mean age = 56.0y) mean preoperative glomerular filtration rate, functional renal volume, and glomerular filtration rate/functional renal volume were 83.2ml/min/1.73m 2 , 340.6cm 3 , and 0.25ml/min/1.73m 2 /cm 3 , respectively. The percent reduction in glomerular filtration rate was statistically significant according to chronic kidney disease stage (no chronic kidney disease 31.2% vs. stage II 26.5% vs. stage III 12.8%, P<0.001). However, the degree of hypertrophic functional renal volume in the remnant kidney was not statistically significant (no chronic kidney disease 18.5% vs. stage II 17.3% vs. stage III 16.5%, P = 0.250). The change in glomerular filtration rate/functional renal volume was statistically significant (no chronic kidney disease 18.5% vs. stage II 20.1% vs. stage III 45.9%, P<0.001). Factors that increased glomerular filtration rate/functional renal volume above the mean value were body mass index (P = 0.012), diabetes mellitus (P = 0.023), hypertension (P = 0.015), and chronic kidney disease stage (P<0.001). Patients with a lower preoperative glomerular filtration rate had a smaller reduction in postoperative renal function than those with a higher preoperative glomerular filtration rate due to greater degrees of functional hyperfiltration. Copyright © 2017. Published by Elsevier Inc.

  11. Networking. La rete come arte

    DEFF Research Database (Denmark)

    Bazzichelli, Tatiana

    of Italian hacker communities. Book written by Tatiana Bazzichelli, with the preface of Derrick De Kerckhove and the epilogue of the videoartist Simonetta Fadda. Costa & Nolan Ed., Milan, Italy, 2006. English edition (2009): Digital Aesthetics Research Center, Aarhus University, Denmark. networkingart.eu/the-book/...

  12. Emergence

    Directory of Open Access Journals (Sweden)

    Raven John

    2014-07-01

    Full Text Available In this paper I first list a number of areas in which recent research seems to reinforce the need to follow through on activities identified in Simonetta Magari’s article (Magari, Cavaleri 2009. A careful review of research in these areas would lead us into deeply mysterious psychological processes and underline the need to change the most fundamental assumptions on which modern psychology is built. Unfortunately, I am in no position to undertake this review.

  13. El dintel 3 del templo IV de Tikal : análisis iconográfico y simbólico de la representación /

    OpenAIRE

    Morselli Barbieri, Simonetta

    2013-01-01

     tesis que para obtener el grado de Doctorado en Historia, presenta Simonetta Morselli Barbieri ; tutores principales de tesis Manuel Hermann Lejarazú, Ma. Teresa Uriarte Castañeda, Gerardo Bustos Trejo. 275 páginas : ilustraciones. Doctorado en Historia Universidad Nacional Autónoma de México, 2013 Programa de Posgrado en Historia

  14. Library Users Expect Link Resolvers to Provide Full Text While Librarians Expect Accurate Results. A review of: Wakimoto, Jina Choi, David S. Walker, and Katherine S. Dabbour. “The Myths and Realities of SFX in Academic Libraries.” The Journal of Academic Librarianship 32.2 (Mar. 2006: 127‐ 36.

    Directory of Open Access Journals (Sweden)

    Wendy Furlan

    2006-12-01

    Full Text Available Objective – To determine how successfulthe link resolver, SFX, is in meeting the expectations of library users and librarians.Design – Analysis of an online user survey, library staff focus groups, retrospective analysis of system statistics, and test searches.Setting – Two California State University campus libraries in the United States: Northbridge, with over 31,000 students on campus, and San Marcos, with over 7,300 students on campus.Subjects – A total of 453 online survey responses were submitted from library users, 421 from Northbridge and 32 from SanMarcos. Twenty librarians took part in the focus groups conducted with library staff consisting of 14 of the 23 librarians from Northbridge (2 from technical services and 12 from public services, and 6 of the 10 San Marcos librarians (3 from technical services and 3 from public services. No further information was provided on the characteristics of the subjects.Methods – An online survey was offered to users of the two campus libraries for a two week period in May 2004. The survey consisted of 8 questions, 7 fixed response and 1 free text. Survey distribution was enabled via a different mechanism at each campus. The Northbridge library offered the survey to users via a pop‐up window each time the SFX service was clicked on, while the San Marcos library presented the survey as a link from the library’s home page. Survey responses from both campuses were combined and analysed together. Focus groups were conducted with librarians from each campus library on April 20th, 21st, and 29th, 2004. Librarians attended focus groups only with others from their own campus. Statistics were gathered from each campus’ local SFX system for the 3‐month period from September 14, 2004, to December 14,2004. Statistics from each campus were combined for analysis. The authors also conducted 224 test searches over the 3‐month period from July to September, 2004.Main results – Analysis of the surveys revealed that 80% of users expected to see a full‐text article online when they clicked on the SFX button; 20% expected to rarely or never see one. Responses also gave an almost equal split when users were asked if the SFX service met their expectations with 49.5% saying it did and 50.5% saying it did not. The free text survey question asking for comments on the user’s overall opinion of SFX received 174 responses, 26% of which were positive, 40% negative, and 34% mixed. The primary theme expressed in 49% of all comments received was disappointment in not gaining full‐text access. Thirty‐three percent of other comments were classed as having a general theme, while the remaining 19% of comments regarding the SFX service were categorised with themes of complexity, technical problems, efficiency, or confusion. Results from the librarian focus groups differed between the two campuses. Northbridge librarians had 50% to 85% confidence in the accuracy of SFX and were generally impressed with the service. San Marcos librarians had 60% to 100% confidence that SFX would work, however it was also discovered that several participants had suspicions regarding the accuracy of the system. The SFX usage statistics obtained covered 188,944 individual uses of SFX at both campuses. Statistics showed that 48% of these uses resulted in the user clicking on an option provided, either linking to full‐text, catalogue look‐up, or inter‐library loan form access. Of total occurrences, 39.7% had a link to full‐text displayed; this link was accessed 65.2% of the time. Forty‐seven percent of SFX uses provided a catalogue link (23.8% of which were accessed and 37.9% of uses provided an inter‐library loan link (8.4% of which were accessed. The test searches revealed anomalies to take into account when analysing the SFX usage statistics, including that about 15% of SFX requests display multiple full‐text links. Of the test searches conducted, 22.2% of fulltext availability results ended in either technical or accuracy errors and 8.8% of catalogue look‐ups produced errors. In those cases where errors did not result there were also significant percentages of instances where the library did not have access to the desired resource: 35.3% of searches correctly indicated that no full text was available, and 57.6% correctly linked to the catalogue to show that the periodical was not held locally. While these are correctly generated system results they are still likely to be seen as unfavourable outcomes by users.Conclusion – The results of the study indicated that both library users’ and librarians’ expectations of SFX were slightly higher than their actual experiences. Librarians’ primary concerns related to the need for more accurate results while library users wanted more full text. It was noted that many complaints associated with SFX were likely to actually be problems with systems that SFX links into rather than the software itself. Although imperfect, SFX, and link resolvers in general, are noted to be a vast improvement on the many separate searches required in the past to locate fulltext and undoubtedly user expectations and demand for 100% seamless accessibility will grow.

  15. High Efficiency Flexible Battery Based on Graphene-carbon Nanotube Hybrid Structure

    Science.gov (United States)

    2015-02-26

    Choi, Carbon 77 1065(2014) 2. Hierarchical NiCo2O4@nickel-sulfide nanoplate arrays for high-performance supercapacitors , Chu Q, Wang W, Wang X...Graphene:Synthesis and Applications, CRC Press ISBN-10: 1439861870 | ISBN-13: 978-1439861875 | Publication Date: October 11, 2011 Handbook of Nanomaterials ...Properties, Carbon Nanomaterials : a review, Nitin Choudhary, Sookhyun Hwang, Wonbong Choi, Springer (2013) 15. Santanu Das and Wonbong Choi, Graphene

  16. Sexual Risk Behavior Among Military Personnel Stationed at Border-Crossing Zones in the Dominican Republic

    Science.gov (United States)

    2010-01-01

    members of the FFAA and were ≥ 18 years of age. Measures The questionnaire was similar to a knowledge, attitudes, and practices (KAP) survey and...1175. 9. Choi YJ, Lee WH, Rha KH, Xin ZC, Choi YD, Choi HK. Masturbation and its relationship to sexual activities of young males in Korean mil- itary...Casey SE, Tommy J, Saldinger M. Changes in HIV/ AIDS/STI knowledge, attitudes and practices among commercial sex workers and military forces in Port Loko

  17. Cognitive Contours: Recent Work on Cross-Cultural Psychology and Its Relevance for Education

    Science.gov (United States)

    Davies, W. Martin

    2007-01-01

    This paper outlines new work in cross-cultural psychology largely drawn from Nisbett, Choi, and Smith ("Cognition," 65, 15-32, 1997); Nisbett, Peng, Choi, & Norenzayan, "Psychological Review," 108(2), 291-310, 2001; Nisbett, "The Geography of Thought: How Asians and Westerners Think Differently...and Why." New…

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Jin Jeon Sae-Gwang Park Su-Kil Seo Jung Sik Choi Sung-Jae Park Eun Bo Shim Il-Whan Choi Won-Kyo Jung · More Details Abstract Fulltext PDF. Marine algae have been utilized in food as well as medicine products for a variety of purposes.

  19. An AFLP marker linked to turnip mosaic virus resistance gene in pak ...

    African Journals Online (AJOL)

    An AFLP marker linked to turnip mosaic virus resistance gene in pak-choi. W Xinhua, C Huoying, Z Yuying, H Ruixian. Abstract. Pak-choi is one of the most important vegetable crops in China. Turnip mosaic virus (TuMV) is one of its main pathogen. Screening the molecular marker linked to the TuMV resistance gene is an ...

  20. Endoplasmic Reticulum-Associated Degradation Factor ERLIN2: Oncogenic Roles and Molecular Targeting of Breast Cancer

    Science.gov (United States)

    2013-06-01

    S Hong, KG Park, IK Lee, CS Choi, RW Hanson, HS Choi and SH Koo. Regulation of hepatic gluconeogenesis by an ER-bound tran- scription factor...cytoplasmic free Ca2+ without generation of inositol phos- phates in NG115-401L neuronal cells. Bio- chem J 1988; 253: 81-86. [17] Y Sagara and G

  1. Latent class analysis on internet and smartphone addiction in college students

    OpenAIRE

    Mok, Jung-Yeon; Choi, Sam-Wook; Kim, Dai-Jin; Choi, Jung-Seok; Lee, Jaewon; Ahn, Heejune; Choi, Eun-Jeung; Song, Won-Young

    2014-01-01

    Jung-Yeon Mok,1 Sam-Wook Choi,1,2 Dai-Jin Kim,3 Jung-Seok Choi,4 Jaewon Lee,2 Heejune Ahn,5 Eun-Jeung Choi,6 Won-Young Song7 1Eulji Addiction Institute, Eulji University, Seoul, South Korea; 2Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea; 3Department of Psychiatry, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea; 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea; 5Depar...

  2. A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor

    Science.gov (United States)

    2015-07-21

    Hybrid Biosensor Jieun Lee1,2, Jaeman Jang1, Bongsik Choi1, Jinsu Yoon1, Jee-Yeon Kim3, Yang-Kyu Choi3, Dong Myong Kim1, Dae Hwan Kim1 & Sung-Jin Choi1...This study demonstrates a hybrid biosensor comprised of a silicon nanowire (SiNW) integrated with an amplifier MOSFET to improve the current response...of field-effect-transistor (FET)-based biosensors . The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential

  3. 77 FR 1936 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-01-12

    ...), 9333 Elm Vista Drive, 9, Downey, CA 90242, Officer: Cynthia Choi, CEO/CFO/Secretary, (Qualifying.... Steele Logistics, LLC (NVO), 10722 La Cienega Blvd., Inglewood, CA 90304, Officer: Rene N. Steele, Member...

  4. Quality assessment and primary uses of harvested rainwater in ...

    African Journals Online (AJOL)

    2013-08-08

    Aug 8, 2013 ... Results indicated that the tank water quality was within all the chemical standards (cations and .... Framework Policy for the Assurance and Promotion of ..... LEE JY, YANG JS, HAN M, and CHOI J (2010) Comparison of the.

  5. Reference: 754 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available . Roles of phosphatidylinositol 3-kinase in root hair growth. 2 624-35 18408046 2008 Jun Plant physiology Bak Gwangbae|Cho Hyung-Taeg|Choi Yunjung|Chuang Wen-I|Lee Youngsook|Lee Yuree

  6. Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

    Index Scriptorium Estoniae

    Kivimaa, Katrin, 1969-

    2005-01-01

    Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

  7. Landslide susceptibility zonation in part of Tehri reservoir region ...

    Indian Academy of Sciences (India)

    Validation of the model was performed by using cumulative ..... thrusts, folds and joints of varying shape and size ...... Lee S, Choi J and Min K 2002 Landslide susceptibility analy- ... cross-validation in three test areas using a frequency.

  8. Investigation of the Antiasthmatic Properties of Ethanol Extract of ...

    African Journals Online (AJOL)

    Investigation of the Antiasthmatic Properties of Ethanol Extract of Callophyllis japonica in Mice. WS Park, KS Lee, JH Chun, SH Urm, DS Lee, DY Lee, SG Park, SK Seo, SJ Heo, ZJ Qian, WK Jung, IW Choi ...

  9. Temperature influence and reset voltage study of bipolar resistive ...

    Indian Academy of Sciences (India)

    Administrator

    which is typical for electronic transportation in a Cu metal. It is indicated ... the defects in the oxide (Choi et al 2005; Waser 2009). Researchers ... and ethanol as starting materials while benzoyl acetone ..... the temperature dependence of Roff.

  10. Maximum daily rainfall in South Korea

    Indian Academy of Sciences (India)

    and Dongseok Choi. 2. 1. School of Mathematics, University of Manchester, Manchester M60 1QD, UK. ... This paper provides the first application of extreme value distributions to rainfall data from South Korea. 1. ..... protection. This paper only ...

  11. 58 Etude du champ lointain de la double hétérostructure laser ...

    African Journals Online (AJOL)

    AKA BOKO

    lointain. Abstract. Study of the far field of the double heterostructure laser. GaInAsSb/GaAlAsSb ... the establishment the conditions for a better coupling of the DH laser with the optical fibres. ..... [4] - H. K. CHOI, G. W. TURNER and S. J. EGLASH, IEEE photonics Technology Letters, Vol. 6 ( 1994) 7. [5] - H. K. CHOI, and S. J. ...

  12. Fulltext PDF

    Indian Academy of Sciences (India)

    2017-09-09

    Sep 9, 2017 ... 102 134105-1. [15] Scott J C and Bozano L D 2007 Adv. Mater. 19 1452. [16] Yang Y C, Pan F, Liu Q, Liu M and Zeng F 2009 Nano Lett. 9. 1636. [17] Lee D, Choi H J, Sim H J, Choi D, Hwang H, Lee M J et al. 2005 IEEE Electron Dev. Lett. 26 719. [18] Guan W H, Long S B, Jia R and Liu M 2007 Appl. Phys.

  13. Preemptive Approach to Improving Survival in Epithelial Ovarian Cancer

    Science.gov (United States)

    2012-06-01

    Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M cell...Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M

  14. Effect of plant species on nitrogen recovery in aquaponics.

    Science.gov (United States)

    Hu, Zhen; Lee, Jae Woo; Chandran, Kartik; Kim, Sungpyo; Brotto, Ariane Coelho; Khanal, Samir Kumar

    2015-01-01

    Nitrogen transformations in aquaponics with different edible plant species, i.e., tomato (Lycopersicon esculentum) and pak choi (Brassica campestris L. subsp. chinensis) were systematically examined and compared. Results showed that nitrogen utilization efficiencies (NUE) of tomato- and pak choi-based aquaponic systems were 41.3% and 34.4%, respectively. The abundance of nitrifying bacteria in tomato-based aquaponics was 4.2-folds higher than that in pak choi-based aquaponics, primarily due to its higher root surface area. In addition, tomato-based aquaponics had better water quality than that of pak choi-based aquaponics. About 1.5-1.9% of nitrogen input were emitted to atmosphere as nitrous oxide (N2O) in tomato- and pak choi-based aquaponic systems, respectively, suggesting that aquaponics is a potential anthropogenic source of N2O emission. Overall, this is the first intensive study that examined the role plant species played in aquaponics, which could provide new strategy in designing and operating an aquaponic system. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Preparation of Solvent-Dispersible Graphene and its Application to Nanocomposites

    Science.gov (United States)

    2016-06-14

    Department of Polymer Science and Engineering ; 80 Daehak Ro, Buk-gu, Daegu 41566, South Korea; Phone: +82-53-950-5630; Fax: +82-53-950-6623. Period of...2011, 115, 5422-5428. 31. E.-Y. Choi, W. S. Choi, Y. B. Lee and Y. –Y. Noh, Nanotechnology , 2011, 22, 365601. DISTRIBUTION A. Approved for public...T. Liu, Composites Part B: Engineering , 2011, 42, 2130-2135. 40. G. S. Bang, H.-M. So, M. J. Lee and C. W. Ahn, J. Mater. Chem., 2012, 22, 4806

  16. Piezoelectric Nanogenerators for Self-Powered Nanosystems and Nanosensors

    Science.gov (United States)

    2013-05-15

    researchers 1. Sangmin Lee, Sung-Hwan Bae, Long Lin, Seunghyun Ahn, Chan Park, Seung Nam Cha, Young Jun Park, Hyuk Chang, Sang-Woo Kim and...Sohn, Seung Nam Cha, Dukhyun Choi * Zhong Lin Wang * Sang-Woo Kim * “ P-Type Polymer–Hybridized High-Performance Piezoelectric Nanogenerators”, Nano...Yoon Lee, † Sang-Woo Kim , *,$ Jae-Young Choi, *,† Jong Min Kim , † and Zhong Lin Wang *, “Flexible Hybrid Multi-Type Energy Scavenger”, Energy

  17. Spatial Control of Crystal Texture by Laser DMD Process

    Science.gov (United States)

    2009-02-01

    Parallel to rolling direction 1120 827 31 205 24 Matweb In718 filler material 1140 414 Charpy Impact Energy (J) Hardness (HRC) Tensile strength (Mpa...J. Choi, K. Nagarathnam, J. Koch, and D. Hetzner, “The direct metal deposition of H13 tool steel for 3-D components,” JOM, 49(5), 1997, 55-60. 4. M...Transactions A, 36A, 2005, 3397-3406. 6. Y. Hua and J. Choi, “Feedback control effects on dimensions and defects of H13 tool steel by DMD process,” J. of Laser Applications, 17(2), 2005, 117-125. 412

  18. Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with ...

    Indian Academy of Sciences (India)

    SEARCHU

    Ribonucleic acids (RNAs) in cells are bound to proteins. Heterogeneous nuclear ribonucleoprotein (hnRNP) is one of the representative proteins bound to RNAs in eukaryotic cells. More than 30 hnRNPs have been determined to exist in human nuclei, and are referred to as hnRNPs A1 through U (Choi and Dreyfuss 1984; ...

  19. A parabolic-hyperbolic system modelling a moving cell

    Directory of Open Access Journals (Sweden)

    Fabiana Cardetti

    2009-08-01

    Full Text Available In this article, we study the existence and uniqueness of local solutions for a moving boundary problem governed by a coupled parabolic-hyperbolic system. The results can be applied to cell movement, extending a result obtained by Choi, Groulx, and Lui in 2005.

  20. Development of a Semi-Autonomous Underwater Vehicle for Intervention Missions (SAUVIM Phase III-C)

    Science.gov (United States)

    2010-01-28

    James Fein from ONR, Mr. Chris Hillenbrand became the ONR Program Officer for the SAUVIM project. In 2002, Dr. David Drumheller became the new ONR...Gary McMurtry, Dr. Song K. Choi & Mr. Oliver T. Easterday Past Personnel: Mr. Yann Douyere, Mr. Alan Parsa & Mr. Max D. Cremer Objectives The

  1. Development of a Semi-Autonomous Underwater Vehicle for Intervention Missions (SAUVIM Phase III-B)

    Science.gov (United States)

    2009-03-20

    departure of Mr. James Fein from ONR, Mr. Chris Hillenbrand became the ONR Program Officer for the SAUVIM project. In 2002, Dr. David Drumheller...Dr. Gary McMurtry, Dr. Song K. Choi & Mr. Oliver T. Easterday Past Personnel: Mr. Yann Douyere, Mr. Alan Parsa & Mr. Max D. Cremer Objectives

  2. Evaluation of Genotoxicity of CSE1034 by Ames and In vitro ...

    African Journals Online (AJOL)

    NADPH) was obtained from Himedia (Mumbai, India). Ames test. The test was ..... W, Passarge E. Toxicity of antibiotics cultured human skin fibroblast. Humangenetik 1975; 28: 273-267. 15. McCann J, Choi E, Yamasaki E, Ames BN. Detection of.

  3. Teisel pool fotot : üleval 70 tööd / Ragne Nukk

    Index Scriptorium Estoniae

    Nukk, Ragne, 1984-

    2011-01-01

    Rahvusvaheline fotonäitus "Teisele poole" Kumu Kunstimuuseumis 8. jaanuarini 2012, kuraator Adam Budak. Eksponeeritakse kollaaže, fotodest valmistatud skulptuure, videosid, fotosid, installatsioone. Lühidalt portugali kunstniku Helena Almeida, sakslase Stefan Burgeri, korea kunstniku Sunah Choi, ameeriklase Marlo Pascuali töödest. Näitus toimub Tallinna fotokuu raames

  4. Vaata mulle näkku: mu nimi on Oleks Võinud Olla / Andreas Sepp

    Index Scriptorium Estoniae

    Sepp, Andreas

    2011-01-01

    Tallinna Fotokuu raames Kumu Kunstimuuseumis rahvusvaheline kaamerakunsti näitus "Teisele poole" 7.10.2011-08.01.2012, kuraator Adam Budak Osaleb 19 kunstnikku, neist tutvustatakse: John Baldessari (California), Sunah Choi (Korea), Haris Epaminonda (Küpros), Helena Almeida (Portugal), Elad Lassry (Iisrael), Alexandre Singh (Prantsusmaa)

  5. Validation of reference genes for real-time quantitative PCR normalisation in non-heading Chinese cabbage

    NARCIS (Netherlands)

    Xiao, D.; Zhang, N.; Jianjun Zhao, Jianjun; Bonnema, A.B.; Hou, X.L.

    2012-01-01

    Non-heading Chinese cabbage is an important vegetable crop that includes pak choi, caixin and several Japanese vegetables like mizuna, mibuna and komatsuna. Gene expression studies are frequently used to unravel the genetics of complex traits and in such studies the proper selection of reference

  6. Multi-Target/Multi-Sensor Tracking using Only Range and Doppler Measurements

    Science.gov (United States)

    2009-04-01

    I+1) k ) represents a global maximum, given the Gaussian components used in our model, and given that P(I) has been fixed using parameter values...on Pattern Analysis and Machine Intelligence, 24 (2002), 381—396. [37] Perlovsky, L. I., Plum, C. P., Franchi , P. R., Tichovolsky, E. J., Choi, D. S

  7. Low temperature preparation of nanocrystalline solid solution of ...

    Indian Academy of Sciences (India)

    Unknown

    tivity and easy hydrolysis of the niobium sources (Choi et al 1990; Narender and Messing 1997; Sekar and ... source of niobium, which overcomes the problems asso- ciated with the reported sources of niobium. The route .... Industrial Research, New Delhi, for the financial grant offered in support of this work. References.

  8. Anti-inflammatory Effects of Magnolia sieboldii Extract in ...

    African Journals Online (AJOL)

    Hao Li4 and Kang-Duk Choi1*. 1Genomic ... Methods: The whole plant of M. sieboldii was extracted with methanol at room temperature. The in vitro ... action of M. sieboldii in inflammation. Magnolia ..... Shih HC, Hwang TL, Chen HC, Kuo PC, Lee EJ, Lee. KH, Wu TS. ... Fu JY, Masferrer JL, Seibert K, Raz A, Needleman P.

  9. Some composition formulae for the M-S-M fractional integral operator with the multi-index Mittag-Leffler functions

    Science.gov (United States)

    Jain, Shilpi; Agarwal, Praveen; Kıymaz, I. Onur; ćetinkaya, Ayá¹£egül

    2018-01-01

    Authors presented some composition formulae for the Marichev-Saigo-Maeda (M-S-M) fractional integral operator with the multi-index Mittag-Leffler functions. Our results are generalizes the results obtained by Choi and Agarwal [3]. Here, we record some particular cases of our main result. Finally, we obtain Laplace transforms of the composition formulae.

  10. Spring Research Festival and NICBR Collaboration Winners Announced | Poster

    Science.gov (United States)

    By Carolynne Keenan, Contributing Writer, and Ashley DeVine, Staff Writer The winners of the 2014 Spring Research Festival (SRF), held May 7 and 8, were recognized on July 2, and included 20 NCI at Frederick researchers: Matthew Anderson, Victor Ayala, Matt Bess, Cristina Bergamaschi, Charlotte Choi, Rami Doueiri, Laura Guasch Pamies, Diana Haines, Saadia Iftikhar, Maria

  11. of Spirostachys africana complicated

    African Journals Online (AJOL)

    C Scott, FCPaed (SA). Department of Paediatrics, Red Cross War Memorial Children's Hospital and University of Cape Town. N P Khumalo, MB ChB, .... Jeung YJ, Lee JY, Oh MJ, Choi DC, Lee BJ. Comparison of the causes and clinical features of drug rash with eosinophilia and systemic symptoms and Stevens-Johnson ...

  12. Karyotype variation and conservation in morphotypes of non-heading Chinese cabbage

    NARCIS (Netherlands)

    Zheng, Jin Shuang; Sun, Cheng Zhen; Xiao, Dong; Zhang, Shu Ning; Bonnema, Guusje; Hou, Xi Lin

    2015-01-01

    Non-heading Chinese cabbage encompasses a wide diversity of morphotypes, like the well-known Pak-choi, Wu ta cai, Cai xin, Tai cai, and Fen nei cai. Despite recent developments in re-sequencing which results in the detection of SNPs, insertions, deletions and copy number variants, there has been

  13. Gene expression profiles in adenosine-treated human mast cells ...

    African Journals Online (AJOL)

    Gene expression profiles in adenosine-treated human mast cells. ... SW Kang, JE Jeong, CH Kim, SH Choi, SH Chae, SA Jun, HJ Cha, JH Kim, YM Lee, YS ... beta 4, ring finger protein, high-mobility group, calmodulin 2, RAN binding protein, ...

  14. Neutraliseeriv valge kuup / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2007-01-01

    XIV Tallinna graafikatriennaal "Poliitiline/Poeetiline" Kumu Kunstimuuseumis kuni 25. XI. Peapreemia pälvis Oscar Munose videoinstallatsioon "Memoriaali projekt", Eesti Panga preemia Haemin Choi. Poliitilisest kunstist. The Elfriede Jelinek School of the English Language'i teosest "Tooda või sure" (Sirp, 2007, 9. XI, lk. 24)

  15. Un Genevois coopte a la tete du Front islamique du salut

    CERN Multimedia

    Merckling, N

    2002-01-01

    "Le Front islamique du salut (FIS), a nomme a la tete de ce parti fondamentaliste un resident genevois, Mourad Dhani, chois parmi trois candidats. Ce physicien algerien est arrive a Geneve il y a 14 ans pour travailler au CERN (1 page).

  16. Manumycin from a new Streptomyces strain shows antagonistic ...

    African Journals Online (AJOL)

    Manumycin from a new Streptomyces strain shows antagonistic effect against methicillin-resistant Staphylococcus aureus (MRSA)/vancomycin-resistant enterococci (VRE) strains from Korean Hospitals. Yun Hee Choi, Seung Sik Cho, Jaya Ram Simkhada, Chi Nam Seong, Hyo Jeong Lee, Hong Seop Moon, Jin Cheol Yoo ...

  17. DsRed gene expression by doxycycline in porcine fibroblasts and ...

    African Journals Online (AJOL)

    DsRed gene expression by doxycycline in porcine fibroblasts and cloned embryos using transposon. SuJin Kim, JoonHo Moon, BegoRoibas da Torre, Islam M Saadeldin, JungTaek Kang, JiYei Choi, SolJi Park, Byeong-Chun Lee, Goo Jang Goo Jang ...

  18. Browse Title Index

    African Journals Online (AJOL)

    Items 51 - 71 of 71 ... Vol 3, No 1 (1999), What Women do in Wartime: gender and conflict in Africa, Details. Jennifer Chiriga. Vol 3, No 1 (1999), Whose Honour, Whose Humiliation: Women, Men and the Economic Crisis in South Korea, Details. Soung-ai Choi. Vol 4, No 2 (2000), Women in Politics and Decision Making in ...

  19. Resilient Excellence: Challenges Faced by Trailblazing Women in U.S. Sport Psychology

    Science.gov (United States)

    Whaley, Diane E.; Krane, Vikki

    2012-01-01

    Consistent with other sciences (e.g., Kass-Simon, 1993; Tang, 2006), the field of kinesiology has been called a "masculine domain," which has an institutionalized culture biased against women (Brackenridge, Mutrie, & Choi, 2005). This paper represents the second part of a larger project that examined the life histories of eight trailblazing women…

  20. Analysis of the early response to chemotherapy in lung cancer using ...

    African Journals Online (AJOL)

    Histogram analysis based on the whole-tumor ROI method is preferred for .... displayed on the y-axis. The histogram ... Wang H, Fei B. Diffusion-weighted MRI for monitoring ... Ahn SJ, Choi SH, Kim YJ, Kim KG, Sohn CH, Han MH,. Chang KH ...

  1. Pt-Pd nanoelectrocatalyst of ultralow Pt content for the oxidation of ...

    Indian Academy of Sciences (India)

    formic acid oxidation on Pt4Pd96 nanoparticles. Keywords. ..... Choi J H, Jeong K J, Dong Y, Han J, Lim T H, Lee J S ... Rhee C K, Kim B J, Ham C, Kim Y J, Song K and Kwon ... Wang R, Liao S and Ji S 2008 J. Power Sources 180 205. 18.

  2. Measuring Cross-Cultural Competence in Soldiers and Cadets: A Comparison of Existing Instruments

    Science.gov (United States)

    2010-11-01

    Choi, 2005; Matsumoto , Yoo, Hirayama, & Petrova, 2005) or attitudes toward specific cultural groups using Implicit Association Tests (e.g., Park, Felix...findings, Ward et al. (2009) found that CQ failed to show incremental validity beyond emotional intelligence in predicting psychological , socio- cultural ...Cracking the nonverbal code: Intercultural competence and gesture recognition across cultures . Journal of Cross- Cultural Psychology , 36, 380-395

  3. Construction of intergeneric conjugal transfer for molecular genetic ...

    African Journals Online (AJOL)

    SAM

    2014-03-26

    Mar 26, 2014 ... The attB integration site in the S. mobaraensis genome was detected as a single attB ... present study, to promote the molecular genetic study of. S. mobaraensis .... further increase in the number of E. coli donor cells. (≥1.25 × 108) (Choi et .... rational mutagenesis and random mutagenesis. Appl. Microbiol.

  4. Compound mitochondrial DNA mutations in a neurological patient ...

    Indian Academy of Sciences (India)

    Compound mitochondrial DNA mutations in a neurological patient with ataxia, myoclonus and deafness. Ji Hoon Park, Bo Ram Yoon, Hye Jin Kim, Phil Hyu Lee, Byung-Ok Choi and Ki Wha Chung. J. Genet. 93, 173–177. Table 1. Variations from the whole mtDNA sequence in the AMDF patient. Mutation. Report. Locus/ ...

  5. Invited Reaction: Influences of Formal Learning, Personal Learning Orientation, and Supportive Learning Environment on Informal Learning

    Science.gov (United States)

    Cseh, Maria; Manikoth, Nisha N.

    2011-01-01

    As the authors of the preceding article (Choi and Jacobs, 2011) have noted, the workplace learning literature shows evidence of the complementary and integrated nature of formal and informal learning in the development of employee competencies. The importance of supportive learning environments in the workplace and of employees' personal learning…

  6. Interactive Algorithms for Unsupervised Machine Learning

    Science.gov (United States)

    2015-06-01

    in Neural Information Processing Systems, 2013. 14 [3] Louigi Addario-Berry, Nicolas Broutin, Luc Devroye, and Gábor Lugosi. On combinato- rial...Myung Jin Choi, Vincent Y F Tan , Animashree Anandkumar, and Alan S Willsky. Learn- ing Latent Tree Graphical Models. Journal of Machine Learning

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Soo-Dong Woo1 Jae Young Choi2 Yeon Ho Je2 Byung Rae Jin3. Department of Plant Medicine, College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, Korea; School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul ...

  8. Pneumothorax size measurements on digital chest radiographs: Intra- and inter- rater reliability.

    Science.gov (United States)

    Thelle, Andreas; Gjerdevik, Miriam; Grydeland, Thomas; Skorge, Trude D; Wentzel-Larsen, Tore; Bakke, Per S

    2015-10-01

    Detailed and reliable methods may be important for discussions on the importance of pneumothorax size in clinical decision-making. Rhea's method is widely used to estimate pneumothorax size in percent based on chest X-rays (CXRs) from three measure points. Choi's addendum is used for anterioposterior projections. The aim of this study was to examine the intrarater and interrater reliability of the Rhea and Choi method using digital CXR in the ward based PACS monitors. Three physicians examined a retrospective series of 80 digital CXRs showing pneumothorax, using Rhea and Choi's method, then repeated in a random order two weeks later. We used the analysis of variance technique by Eliasziw et al. to assess the intrarater and interrater reliability in altogether 480 estimations of pneumothorax size. Estimated pneumothorax sizes ranged between 5% and 100%. The intrarater reliability coefficient was 0.98 (95% one-sided lower-limit confidence interval C 0.96), and the interrater reliability coefficient was 0.95 (95% one-sided lower-limit confidence interval 0.93). This study has shown that the Rhea and Choi method for calculating pneumothorax size has high intrarater and interrater reliability. These results are valid across gender, side of pneumothorax and whether the patient is diagnosed with primary or secondary pneumothorax. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  9. Conveyance estimation in channels with emergent bank vegetation

    African Journals Online (AJOL)

    2009-03-20

    Mar 20, 2009 ... tion of the transverse distribution of the depth-averaged velocity. Recommendations ... resistance coefficient, and the coefficient for the vegetation interface. ... on the channel hydraulics, including the turbulence structure. (e.g. Choi .... characteristics within the zone as well as the flow conditions in the clear ...

  10. Genetic diversity studies of Kherigarh cattle based on microsatellite ...

    Indian Academy of Sciences (India)

    agricultural plant species, most or all genetic diversity in live- stock exists within ..... African cattle breeds (0.506–0.697; Ibeagha-Awemu et al. 2004). However .... relationships among populations of Asian goats (Capra hircus). J. Anim. Breed. ... 120,. 73–87. Kim K. S., Yeo J. S. and Choi C. B. 2002 Genetic diversity of north-.

  11. Conversion of DST Group Shape Optimisation Software for Increased Portability across Computing Platforms

    Science.gov (United States)

    2016-05-01

    reduction achieved is small due to the starting shape being near optimal. The general arrangement and x-y coordinate system are shown in Figure 23...Optimization, Vol. 28, pp. 55–68, 2004. [3] M Heller, J Calero, S Barter , RJ Wescott, J Choi. Fatigue life extension program for LAU-7 missile launcher

  12. QTL Information Table: 294 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available a Stangoulis, J.C.R., Huynh, B.-L., Welch, R.M., Choi, E.-Y., and Graham, R.D. Quantitative trait loci for phytate in rice grain... and their relationship with grain micronutrient content. Euphytica. http://dx.doi.org/10.1007/s10681-006-9211-7 ...

  13. An interpolation problem for completely positive maps on matrix algebras: solvability and parametrization

    Czech Academy of Sciences Publication Activity Database

    Ambrozie, Calin-Grigore; Gheondea, A.

    2015-01-01

    Roč. 63, č. 4 (2015), s. 826-851 ISSN 0308-1087 R&D Projects: GA AV ČR IAA100190903 Institutional support: RVO:67985840 Keywords : Choi matrix * completely positive * density matrix Subject RIV: BA - General Mathematics Impact factor: 0.761, year: 2015 http://www.tandfonline.com/doi/abs/10.1080/03081087.2014.903253

  14. Identification of salt-stress induced differentially expressed genes in ...

    African Journals Online (AJOL)

    Identification of salt-stress induced differentially expressed genes in barley leaves using the annealingcontrol- primer-based GeneFishing technique. S Lee, K Lee, K Kim, GJ Choi, SH Yoon, HC Ji, S Seo, YC Lim, N Ahsan ...

  15. Growth characteristics and productivity of cold-tolerant “Kowinearly ...

    African Journals Online (AJOL)

    Growth characteristics and productivity of cold-tolerant “Kowinearly” Italian ryegrass in the northern part of South Korea. Gi Jun Choi, Hee Chung Ji, Ki-Yong Kim, Hyung Soo Park, Sung Seo, Ki-Won Lee, Sang-Hoon Lee ...

  16. Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

    African Journals Online (AJOL)

    Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

  17. Emerging Solar Technologies: Perovskite Solar Cell

    Indian Academy of Sciences (India)

    energy technologies and ... cost-effective and feasible non-silicon solar cell technologies. ..... storing in the air for long periods, and the stability reached up to .... [12] Y Liu, L A Renna, M Bag, Z A Page, P Kim, J Choi, T Emrick, D Venkatara-.

  18. High-Performance Liquid Chromatography–Mass Spectrometry Analysis of Plant Metabolites in Brassicaceae

    NARCIS (Netherlands)

    Vos, de C.H.; Schipper, A.; Hall, R.D.

    2012-01-01

    The Brassicaceae family comprises a variety of plant species that are of high economic importance as -vegetables or industrial crops. This includes crops such as Brassica rapa (turnip, Bok Choi), B. oleracea (cabbages, broccoli, cauliflower, etc.), and B. napus (oil seed rape), and also includes the

  19. High frequency plant regeneration from mature seed- derived callus ...

    African Journals Online (AJOL)

    PRECIOUS

    2009-12-15

    Dec 15, 2009 ... Ki-Won Lee, Gi Jun Choi, Ki-Yong Kim, Hee Chung Ji, Hyung Soo Park, Sei Hyung Yoon and ... Gramineae family plants (Ha et al., 2001; Dong and Qu, ..... Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, ...

  20. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-27

    ... & OFF), 1515 Kona Drive, Compton, CA 90220, Officers: Won Rok (aka Steve) Choi, CFO (QI), Myeong H. Kim..., El Monte, CA 91731, Officers: Lynn H. Tran, Secretary (QI), Zheng Feng, CFO, Application Type: New.... 25th Street, Suite 107D, Miami, FL 33182, Officers: Sergio I. Lotero, President (QI), Stephen A. Blass...

  1. Theory of direct-interband-transition line shapes based on Mori's method

    International Nuclear Information System (INIS)

    Sam Nyung Yi; Jai Yon Ryu; Ok Hee Chung; Joung Young Sug; Sang Don Choi; Yeon Choon Chung

    1987-01-01

    A theory of direct interband optical transition in the electron-phonon system is introduced on the basis of the Kubo formalism and by using Mori's method of calculation. The line shape functions are introduced in two different ways and are compared with those obtained by Choi and Chung based on Argyres and Sigel's projection technique

  2. Interpolation for completely positive maps: Numerical solutions

    Czech Academy of Sciences Publication Activity Database

    Ambrozie, Calin-Grigore; Gheondea, A.

    2018-01-01

    Roč. 61, č. 1 (2018), s. 13-22 ISSN 1220-3874 Institutional support: RVO:67985840 Keywords : Choi matrix * completely positive * convex minimization Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 0.362, year: 2016 http://ssmr.ro/bulletin/volumes/61-1/node3.html

  3. Identification and validation of vesicant therapeutic targets using a high, throughput siRNA screening approach

    Science.gov (United States)

    2014-12-24

    et al. 2004; Sabourin et al. 2004). These can be categorized broadly into inflammatory and apoptotic/necrotic pathways. Several other studies have...10.1002/jbt.20321 Sabourin CL, Rogers JV, Choi YW et al (2004) Time- and dose- dependent analysis of gene expression using microarrays in sulfur

  4. Attack pattern of Platypus koryoensis (Coleoptera: Curculionidae: Platypodidae) in relation to crown dieback of Mongolian oak in Korea

    Science.gov (United States)

    Jung-Su Lee; Robert A. Haack; Won Il. Choi

    2011-01-01

    The ambrosia beetle, Platypus koryoensis (Murayama), vectors the Korean oak wilt (KOW) pathogen, Raffaelea quercus-mongolicae K.H. Kim, Y.J. Choi, & H.D. Shin, in Korea, which is highly lethal to Mongolian oak, Quercus mongolica Fisch., and is considered a major threat to forest ecosystem health. We...

  5. Analytical methods for prefiltering of close approaches between ...

    African Journals Online (AJOL)

    user

    2010-02-10

    Feb 10, 2010 ... find out the close approach for all objects with simulations. ... the operational satellite and other orbiting objects. ... Recently, space scientists all over the Globe are giving much ... avoidances (Alarcon-Rodriguez et al., 2004, Gronchi, 2005 and Choi et al., 2009) for the stability of future Low Earth Orbit (LEO).

  6. Demonized No More: The Spiritual Journeys and Spaces of Black Gay Male College Students at Predominantly White Institutions

    Science.gov (United States)

    Means, Darris R.

    2014-01-01

    Spirituality plays a significant role in the lives of college students (Astin, Astin, & Lindholm, 2011; Bryant, Choi, & Yasuno, 2003; Chickering, 2006; Parks, 2000). However, Black gay males are uniquely positioned with regards to spirituality given how race, gender, and sexual orientation are generally perceived and experienced in the…

  7. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Rajendra Bhatia Man-Duen Choi · More Details Abstract Fulltext PDF. We study various conditions on matrices and under which they can be the off-diagonal blocks of a partitioned normal matrix. pp 401-409 Operator Theory/Operator Algebras/Quantum Invariants. Nice Surjections on Spaces of Operators · T S S R K ...

  8. Pro-lipogenic Action of Lysophosphatidic Acid in Ovarian Cancer

    Science.gov (United States)

    2014-04-01

    Function. IUBMB Life. 2008. 60: 347-354. 11. Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, Johnson EF, Marsh KC , Mitten MJ, Nimmer P...Ann. Oncol. 9, 437–442 14. Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C. W., Mutoh, T., Lin, M. E., Teo , S. T., Park, K. E., Mosley, A

  9. Sokoto Journal of Veterinary Sciences Epiphyseal plate closure of ...

    African Journals Online (AJOL)

    ADEYEYE

    Nigeria. 2. Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University. Sokoto, Nigeria ... from three different small ruminant farms with birth record within Sokoto metropolis,. Nigeria. They were ... animals, one of which is the use of epiphyseal plate closure (Choi et al., ...

  10. Supply Network Enabled Innovation Within a Non-repetitive Manufacturing Context

    DEFF Research Database (Denmark)

    Kavin, Lone

    Afhandlingen tager udgangspunkt i det faktum, at innovation er en vigtig forudsætning for at være vedholdende og succesfuld i et konkurrencepræget og globalt miljø (Ageron et al., 2013; Choi and Krause, 2006; Narasimhan and Narayanan, 2013; Pittaway et al., 2004; Zimmermann et al., 2016). Endvide...

  11. Comparison of performance of various tumour response criteria in assessment of regorafenib activity in advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib.

    Science.gov (United States)

    Shinagare, Atul B; Jagannathan, Jyothi P; Kurra, Vikram; Urban, Trinity; Manola, Judith; Choy, Edwin; Demetri, George D; George, Suzanne; Ramaiya, Nikhil H

    2014-03-01

    To compare performance of various tumour response criteria (TRCs) in assessment of regorafenib activity in patients with advanced gastrointestinal stromal tumour (GIST) with prior failure of imatinib and sunitinib. Twenty participants in a phase II trial received oral regorafenib (median duration 47 weeks; interquartile range (IQR) 24-88) with computed tomography (CT) imaging at baseline and every two months thereafter. Tumour response was prospectively determined on using Response Evaluation Criteria in Solid Tumours (RECIST) 1.1, and retrospectively reassessed for comparison per RECIST 1.0, World Health Organization (WHO) and Choi criteria, using the same target lesions. Clinical benefit rate [CBR; complete or partial response (CR or PR) or stable disease (SD)≥16 weeks] and progression-free survival (PFS) were compared between various TRCs using kappa statistics. Performance of TRCs in predicting overall survival (OS) was compared by comparing OS in groups with progression-free intervals less than or greater than 20 weeks by each TRC using c-statistics. PR was more frequent by Choi (90%) than RECIST 1.1, RECIST 1.0 and WHO (20% each), however, CBR was similar between various TRCs (overall CBR 85-90%, 95-100% agreement between all TRC pairs). PFS per RECIST 1.0 was similar to RECIST 1.1 (median 44 weeks versus 58 weeks), and shorter for WHO (median 34 weeks) and Choi (median 24 weeks). With RECIST 1.1, RECIST 1.0 and WHO, there was moderate concordance between PFS and OS (c-statistics 0.596-0.679). Choi criteria had less favourable concordance (c-statistic 0.506). RECIST 1.1 and WHO performed somewhat better than Choi criteria as TRC for response evaluation in patients with advanced GIST after prior failure on imatinib and sunitinib. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Quantitative therapy response assessment by volumetric iodine-uptake measurement: Initial experience in patients with advanced hepatocellular carcinoma treated with sorafenib

    International Nuclear Information System (INIS)

    Dai, Xu; Schlemmer, Heinz-Peter; Schmidt, Bernhard; Höh, Karolin; Xu, Ke; Ganten, Tom M.; Ganten, Maria-Katharina

    2013-01-01

    Objectives: To investigate the volumetric iodine-uptake (VIU) changes by dual-energy CT (DECT) in assessing the response to sorafenib treated hepatocellular carcinoma (HCC) patients, compared with AASLD (American Association for the Study of Liver Diseases) and Choi criteria. Materials and methods: Fifteen patients with HCC receiving sorafenib, monitored with contrast-enhanced DECT scans at baseline and a minimum of one follow-up (8–12 weeks) were retrospectively evaluated. 30 target lesions in total were analyzed for tumor response according to VIU and adapted Choi criteria and compared with the standard AASLD. Results: According to AASLD criteria, 67% target lesions showed disease control: partial response (PR) in 3% and stable disease (SD) in 63%. 33% lesions progressed (PD). Disease control rate presented by VIU (60%) was similar to AASLD (67%) and Choi (63%) (P > 0.05). For disease control group, change in mean VIU was from 149.5 ± 338.3 mg to 108.5 ± 284.1 mg (decreased 19.1 ± 42.9%); and for progressive disease group, change in mean VIU was from 163.7 ± 346.7 mg to 263.9 ± 537.2 mg (increased 230.5 ± 253.1%). Compared to AASLD (PR, 3%), VIU and Choi presented more PR (33% and 30%, respectively) in disease control group (P < 0.05). VIU has moderate consistency with both AASLD (kappa = 0.714; P < 0.005) and Choi (kappa = 0.648; P < 0.005), while VIU showed a better consistency and correlation with AASLD (kappa = 0.714; P < 0.005; r = 0.666, P < 0.005) than Choi with AASLD (kappa = 0.634, P < 0.005; r = 0.102, P = 0.296). Conclusion: VIU measurements by DECT can evaluate the disease control consistent with the current standard AASLD. Measurements are semi-automatic and therefore easy and robust to apply. As VIU reflects vital tumor burden in HCC, it is likely to be an optimal tumor response biomarker in HCC

  13. ATLAS rewards two pixel detector suppliers

    CERN Multimedia

    2007-01-01

    Peter Jenni, ATLAS spokesperson, presented the ATLAS supplier award to Herbert Reichl, IZM director, and to Simonetta Di Gioia, from the SELEX company.Two of ATLAS’ suppliers were awarded prizes at a ceremony on Wednesday 13 June attended by representatives of the experiment’s management and of CERN. The prizes went to the Fraunhofer Institut für Zuverlässigkeit und Mikrointegration (IZM) in Berlin and the company SELEX Sistemi Integrati in Rome for the manufacture of modules for the ATLAS pixel detector. SELEX supplied 1500 of the modules for the tracker, while IZM produced a further 1300. The modules, each made up of 46080 channels, form the active part of the ATLAS pixel detector. IZM and SELEX received the awards for the excellent quality of their work: the average number of faulty channels per module was less than 2.10-3. They also stayed within budget and on schedule. The difficulty they faced was designing modules based on electronic components and sensor...

  14. Z-Elongation of the transverse carpal ligament vs. complete resection for the treatment of carpal tunnel syndrome.

    Science.gov (United States)

    Castro-Menéndez, M; Pagazaurtundúa-Gómez, S; Pena-Paz, S; Huici-Izco, R; Rodríguez-Casas, N; Montero-Viéites, A

    Carpal tunnel syndrome is treated successfully by surgical release of the transverse carpal ligament (TCL). However, persistent weakness of grip and pain over the thenar and hypothenar ends of this ligament, and "pillar pain", are reported to be common complications. In order to reduce these complications, different ligament reconstruction or lengthening techniques have been proposed. The purpose of this study is compare effectiveness and complications of TCL z-lengthening technique with complete TCL section. A prospective, randomised, intervention trial was conducted on 80 patients. The patients were divided into 2 groups: 1) complete release of TCL; 2) z-lengthening of TCL according to a modified Simonetta technique. Grip strength, pillar pain and clinical and functional assessment were carried out using the Levine et al. questionnaire. No significant differences were observed (p>.05) in the postoperative reviews between the two groups as regards grip strength loss and pillar pain. There were significant differences between preoperative and postoperative mean Levine scores, but there was no difference in the mean scores of the two procedures at any time. In conclusion, according to the results, TCL z-lengthening is more effective than simple division, but there is no identifiable benefit in z-lengthening for avoiding complications. Copyright © 2016 SECOT. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. 7 July 2011 - Members of the Swiss Federal Council (front row) in front of the Globe of Science and Innovation.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    CERN-HI-1107166 01 1er rang: La chancelière Corina Casanova, le conseiller fédéral Johann N. Schneider-Ammann, le conseiller fédéral Ueli Maurer, la conseillère fédérale Eveline Widmer-Schlumpf, la conseillère fédérale Simonetta Sommaruga, la Présidente de la Confédération Micheline Calmy-Rey, le Directeur général du CERN Rolf Heuer, la conseillère fédérale Doris Leuthard, le conseiller fédéral Didier Burkhalter. 2è rang: Le vice-chancelier André Simonazzi , le vice-chancelier Thomas Helbling, la chef des relations internationales Felicitas Pauss, le directeur de la recherche et du calcul scientifique Sergio Bertolucci. 3è rang: Les scientifiques suisses: Ulrich Straumann (LHCb, Zürich et délégué suisse au Conseil du CERN), Rainer Wallny (CMS, ETHZ), Günther Dissertori (CMS, ETHZ), Antonio Ereditato (ATLAS, Bern), Tatsuya Nakada (LHCb, EPFL), Olivier Schneider (LHCb, EPFL), Martin Pohl (ATLAS, Genève), Vincenzo Chiochia (CM, Zürich), Giuseppe Iacobucci (ATLAS, Genève), le C...

  16. Data of methylome and transcriptome derived from human dilated cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Bong-Seok Jo

    2016-12-01

    Full Text Available Alterations in DNA methylation and gene expression have been implicated in the development of human dilated cardiomyopathy (DCM. Differentially methylated probes (DMPs and differentially expressed genes (DEGs were identified between the left ventricle (LV, a pathological locus for DCM and the right ventricle (RV, a proxy for normal hearts. The data in this DiB are for supporting our report entitled “Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy” (Bong-Seok Jo, In-Uk Koh, Jae-Bum Bae, Ho-Yeong Yu, Eun-Seok Jeon, Hae-Young Lee, Jae-Joong Kim, Murim Choi, Sun Shim Choi, 2016 [1].

  17. IPD-Work consortium

    DEFF Research Database (Denmark)

    Kivimäki, Mika; Singh-Manoux, Archana; Virtanen, Marianna

    2015-01-01

    of countries. The aim of the consortium is to estimate reliably the associations of work-related psychosocial factors with chronic diseases, disability, and mortality. Our findings are highly cited by the occupational health, epidemiology, and clinical medicine research community. However, some of the IPD-Work......'s findings have also generated disagreement as they challenge the importance of job strain as a major target for coronary heart disease (CHD) prevention, this is reflected in the critical discussion paper by Choi et al (1). In this invited reply to Choi et al, we aim to (i) describe how IPD-Work seeks......Established in 2008 and comprising over 60 researchers, the IPD-Work (individual-participant data meta-analysis in working populations) consortium is a collaborative research project that uses pre-defined meta-analyses of individual-participant data from multiple cohort studies representing a range...

  18. Holistic Reasoning on the Other Side of the World: Validation of the Analism/Holism Scale in Mexicans

    Science.gov (United States)

    Lechuga, Julia; Santos, Beatriz Maldonado; Garza-Caballero, Azenett A.; Villarreal, Ricardo

    2011-01-01

    The universality of cognitive processes has been called into question. Research suggests that individuals from Eastern cultures (e.g., China, Korea) when compared to individuals from Western cultures (e.g., the United States) prefer to reason holistically. This line of research has not been extended to cultural groups far removed from cultures traditionally surveyed in cross-cultural research such as Hispanics. We conducted two studies to understand: 1) the generalizability of the construct of holistic reasoning in Mexicans, and 2) the preferred reasoning style of Mexicans when compared to U.S. Americans. Results support the generalization of the factor structure of holistic reasoning as originally hypothesized by Choi, Koo, and Choi (2007). The results of Study 2 suggest that Mexicans scored higher than U.S. Americans on certain aspects of holistic reasoning. PMID:21787065

  19. Holistic reasoning on the other side of the world: validation of the analysis-holism scale in Mexicans.

    Science.gov (United States)

    Lechuga, Julia; Santos, Beatriz Maldonado; Garza-Caballero, Azenett A; Villarreal, Ricardo

    2011-07-01

    The universality of cognitive processes has been called into question. Research suggests that individuals from Eastern cultures (e.g., China, Korea) when compared to individuals from Western cultures (e.g., the United States) prefer to reason holistically. This line of research has not been extended to cultural groups far removed from cultures traditionally surveyed in cross-cultural research such as Hispanics. We conducted two studies to understand: 1) the generalizability of the construct of holistic reasoning in Mexicans, and 2) the preferred reasoning style of Mexicans when compared to U.S. Americans. Results support the generalization of the factor structure of holistic reasoning as originally hypothesized by Choi, Koo, and Choi (2007). The results of Study 2 suggest that Mexicans scored higher than U.S. Americans on certain aspects of holistic reasoning.

  20. Assessment of Intelligent Tutoring Systems Technologies and Opportunities (Evaluation et opportunites des technologies des systemes de tutorat intelligents)

    Science.gov (United States)

    2018-01-01

    6) Conflict Resolution − Interpersonal skills, mutual trust, and psychological safety enabling people to be assertive about and take accountability...Gustafson, S., Beaubein, J., Salas, E. and Barach, P. (2005). Medical Teamwork and Patient Safety : The Evidence-based Relation. Agency for Healthcare...Or-Bach. • Japan (JPN) – 2: Riichiro Mizoguchi; Kazuhsia Seta. • Korea (KOR) – 1: Key Sun Choi. • Luxembourg (LUX) – 1: Samuel Greiff. • Malaysia

  1. Modeling Real-Time Human-Automation Collaborative Scheduling of Unmanned Vehicles

    Science.gov (United States)

    2013-06-01

    Bundle Algorithm (CBBA), a decentralized, polynomial-time, market based protocol (Choi, et al., 2009). More details on the AS can be found in (Whitten...infonned consent to panicipate in this research study. Signature oflnvesligator Date Approved on 31-0CT-2012 - MIT JRB Protocol #: 1110005179- Expires on...presented at the IEEE International Conference on Robotics and Automation, Karlsruhe, Germany. Miller, C. (2004). Human-Computer Etiquette : Managing

  2. Thin Film Assembly of Spider Silk-like Block Copolymers

    Science.gov (United States)

    2011-01-01

    Shipley, N. H.; Lewis, R. V. Int. J. Biol.Macromol. 1999, 24, 271. (c) Thiel, B. L.; Guess, K. B.; Viney, C. Biopolymers 1997, 41, 703. (13) Silk ...Film Assembly of Spider Silk -like Block Copolymers Sreevidhya T. Krishnaji,†,‡ Wenwen Huang,§ Olena Rabotyagova,†,‡ Eugenia Kharlampieva, ) Ikjun Choi...Received November 26, 2010 We report the self-assembly of monolayers of spider silk -like block copolymers. Langmuir isotherms were obtained for a series of

  3. Automatic Modulation Classification of LFM and Polyphase-coded Radar Signals

    Directory of Open Access Journals (Sweden)

    S. B. S. Hanbali

    2017-12-01

    Full Text Available There are several techniques for detecting and classifying low probability of intercept radar signals such as Wigner distribution, Choi-Williams distribution and time-frequency rate distribution, but these distributions require high SNR. To overcome this problem, we propose a new technique for detecting and classifying linear frequency modulation signal and polyphase coded signals using optimum fractional Fourier transform at low SNR. The theoretical analysis and simulation experiments demonstrate the validity and efficiency of the proposed method.

  4. Supply Chain Security. Tools, Trends, and Techniques : Toyota and Honda cases

    OpenAIRE

    Klimova, Nadezda; Akimova, Anna

    2011-01-01

      Supply chain management has experienced great changes within the last fifty years. Inevitably, many companies entered the global market with the prime intention to achieve their defined goals. In comparison with the local markets, the global environment requires more efforts and changes in the supply chain operation in order to remain viable in business. Several business models are introduced for achieving the success in the market, suggested by the following researchers: Liker, Choi, Ronal...

  5. Time-frequency distributions for propulsion-system diagnostics

    Science.gov (United States)

    Griffin, Michael E.; Tulpule, Sharayu

    1991-12-01

    The Wigner distribution and its smoothed versions, i.e., Choi-Williams and Gaussian kernels, are evaluated for propulsion system diagnostics. The approach is intended for off-line kernel design by using the ambiguity domain to select the appropriate Gaussian kernel. The features produced by the Wigner distribution and its smoothed versions correlate remarkably well with documented failure indications. The selection of the kernel on the other hand is very subjective for our unstructured data.

  6. Non-Markovianity of Gaussian Channels.

    Science.gov (United States)

    Torre, G; Roga, W; Illuminati, F

    2015-08-14

    We introduce a necessary and sufficient criterion for the non-Markovianity of Gaussian quantum dynamical maps based on the violation of divisibility. The criterion is derived by defining a general vectorial representation of the covariance matrix which is then exploited to determine the condition for the complete positivity of partial maps associated with arbitrary time intervals. Such construction does not rely on the Choi-Jamiolkowski representation and does not require optimization over states.

  7. Prognostic significance of immunohistochemistry-based markers and algorithms in immunochemotherapy-treated diffuse large B cell lymphoma patients.

    Science.gov (United States)

    Culpin, Rachel E; Sieniawski, Michal; Angus, Brian; Menon, Geetha K; Proctor, Stephen J; Milne, Paul; McCabe, Kate; Mainou-Fowler, Tryfonia

    2013-12-01

    To reassess the prognostic validity of immunohistochemical markers and algorithms identified in the CHOP era in immunochemotherapy-treated diffuse large B cell lymphoma patients. The prognostic significance of immunohistochemical markers (CD10, Bcl-6, Bcl-2, MUM1, Ki-67, CD5, GCET1, FoxP1, LMO2) and algorithms (Hans, Hans*, Muris, Choi, Choi*, Nyman, Visco-Young, Tally) was assessed using clinical diagnostic blocks taken from an unselected, population-based cohort of 190 patients treated with R-CHOP. Dichotomizing expression, low CD10 (<10%), low LMO2 (<70%) or high Bcl-2 (≥80%) predicted shorter overall survival (OS; P = 0.033, P = 0.010 and P = 0.008, respectively). High Bcl-2 (≥80%), low Bcl-6 (<60%), low GCET1 (<20%) or low LMO2 (<70%) predicted shorter progression-free survival (PFS; P = 0.001, P = 0.048, P = 0.045 and P = 0.002, respectively). The Hans, Hans* and Muris classifiers predicted OS (P = 0.022, P = 0.037 and P = 0.011) and PFS (P = 0.021, P = 0.020 and P = 0.004). The Choi, Choi* and Tally were associated with PFS (P = 0.049, P = 0.009 and P = 0.023). In multivariate analysis, the International Prognostic Index (IPI) was the only independent predictor of outcome (OS; HR: 2.60, P < 0.001 and PFS; HR: 2.91, P < 0.001). Results highlight the controversy surrounding immunohistochemistry-based algorithms in the R-CHOP era. The need for more robust markers, applicable to the clinic, for incorporation into improved prognostic systems is emphasized. © 2013 John Wiley & Sons Ltd.

  8. High resolution time- and 2-dimensional space-resolved x-ray imaging of plasmas at NOVA

    International Nuclear Information System (INIS)

    Landen, O.L.

    1992-01-01

    A streaked multiple pinhole camera technique, first used by P. Choi et al. to record time- and 2-D space-resolved soft X-ray images of plasma pinches, has been implemented on laser plasmas at NOVA. The instrument is particularly useful for time-resolved imaging of small sources ( 2.5 key imaging, complementing the existing 1--3 key streaked X-ray microscope capabilities at NOVA

  9. Choice Shifts in Groups: A Decision-Theoretic Basis

    OpenAIRE

    Kfir Eliaz; Debraj Ray; Ronny Razin

    2006-01-01

    The phenomenon of choice shifts in group decision-making has received attention in the social psychology literature. Faced with a risky group decision, individuals appear to support more extreme choices relative to those they would make on their own. This paper demonstrates that from a decision-theoretic perspective, choice shifts are intimately connected to failures of expected utility theory. In the model studied here, the Allais paradox is equivalent to a well-studied configuration of choi...

  10. Microstructural evolution and mechanical properties of hypereutectic ...

    Indian Academy of Sciences (India)

    Administrator

    2013-07-06

    Jul 6, 2013 ... dered (Hekmat-Ardakan et al 2010; Choi and Li 2012). Usually, the .... According to Clapeyron equation (Yu et al 1999) m. 2. 1 m. (. ) d d ,. T V. V. T. P. H. -. = ∆. (1) .... Jung H K, Seo P K and Kang C G 2001 J. Mater. Process. Technol ... Res. 14 141. Zhang H H, Duan H L, Shao G J, Xu L P, Yin J L and Yan B.

  11. On the (In)Validity of Tests of Simple Mediation: Threats and Solutions

    OpenAIRE

    Pek, Jolynn; Hoyle, Rick H.

    2016-01-01

    Mediation analysis is a popular framework for identifying underlying mechanisms in social psychology. In the context of simple mediation, we review and discuss the implications of three facets of mediation analysis: (a) conceptualization of the relations between the variables, (b) statistical approaches, and (c) relevant elements of design. We also highlight the issue of equivalent models that are inherent in simple mediation. The extent to which results are meaningful stem directly from choi...

  12. Polaractivation for classical zero-error capacity of qudit channels

    Energy Technology Data Exchange (ETDEWEB)

    Gyongyosi, Laszlo, E-mail: gyongyosi@hit.bme.hu [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117, Hungary and Information Systems Research Group, Mathematics and Natural Sciences, Hungarian Ac (Hungary); Imre, Sandor [Quantum Technologies Laboratory, Department of Telecommunications, Budapest University of Technology and Economics, 2 Magyar tudosok krt, Budapest, H-1117 (Hungary)

    2014-12-04

    We introduce a new phenomenon for zero-error transmission of classical information over quantum channels that initially were not able for zero-error classical communication. The effect is called polaractivation, and the result is similar to the superactivation effect. We use the Choi-Jamiolkowski isomorphism and the Schmidt-theorem to prove the polaractivation of classical zero-error capacity and define the polaractivator channel coding scheme.

  13. Infection Casualty Estimation (ICE) Model: Predicting Sepsis in Nuclear Detonation Burn Patient Populations using Procalcitonin as a Biomarker

    Science.gov (United States)

    2017-06-06

    Lichtheimia species. Clinical microbiology reviews 24: 411-445; 2011. Gomez R, Murray CK, Hospenthal DR, Cancio LC, Renz EM , Holcomb JB, Wade CE, Wolf SE...Oughterson AW. Medical effects of the atomic bomb in Japan. 1956. Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis...Cancio LC, Renz EM , Horvath EE, White CE, Park MS, Wanek S, Albrecht MA. Comparison between civilian burns and combat burns from Operation Iraqi Freedom

  14. Who is Willing to Let Ethics Guide His Economic Decision-Making? Evidence from Individual Investments in Ethical Funds

    OpenAIRE

    Säve-Söderbergh, Jenny

    2005-01-01

    Recent economics literature has devoted attention towards motives beyond the typical selfish norm for economic decision-making. Yet, it still remains a puzzle who allows such considerations to govern their behavior. This paper contributes by empirically identifying some features which differentiate individuals who choose to bear the cost of ethically guided economic decision-making from others. Using unique Swedish data on individual pension portfolio choices, we find that education, the choi...

  15. Simultaneous Extraction of Lithium and Hydrogen from Seawater

    Science.gov (United States)

    2011-08-22

    N00014-10-M-0234 20126083 0001AD Dr. Pyoungho Choi University of Central Florida/Florida Solar Energy Center 1679 Clearlake Road Cocoa FL 32922-5703...South America (Bolivia and Chile), Australia, and China. There have been debates as to whether the lithium supplies would meet the surging demand...extract the lithium in seawater should be developed [1]. Seawater is also the ultimate source of hydrogen. The production of hydrogen from seawater is

  16. Energy Harvesting Through Optical Properties of TiO2 and C- TiO2 Nanofluid for Direct Absorption Solar Collectors

    OpenAIRE

    alagappan, subramaniyan; Subramaniyan, A. L.; Lakshmi Priya, S.; Ilangovan, R.

    2016-01-01

    Nanofluids are tailored suspensions of nanoparticles in a suitable base fluid. The discovery of  nanofluids by Stephen choi opened a new heat transfer mechanism. Since then several research has taken place to explore thermal, electrical and magnetic property of nanofluids. Nanofluids showed enhanced electrical and thermal conductivities. The nanofluids are also proved as a potential candidate for direct absorption solar collectors (DASC). The present work investigates the effect of nanopartic...

  17. Volume of the space of qubit-qubit channels and state transformations under random quantum channels

    OpenAIRE

    Lovas, Attila; Andai, Attila

    2017-01-01

    The simplest building blocks for quantum computations are the qubit-qubit quantum channels. In this paper, we analyze the structure of these channels via their Choi representation. The restriction of a quantum channel to the space of classical states (i.e. probability distributions) is called the underlying classical channel. The structure of quantum channels over a fixed classical channel is studied, the volume of general and unital qubit channels with respect to the Lebesgue measure is comp...

  18. Brand Loyalty: A Study of the Prevalent Usage of Celebrity Endorsement in Cosmetics Advertising.

    OpenAIRE

    Löfgren, Emma; Li, Juan

    2010-01-01

    The usage of celebrity endorsements has been confirmed to result in more favorableadvertisement ratings and positive product evolutions (Dean and Biswas, 2001). It has evenbecome one of the most popular forms of retail advertising (Choi and Rifon, 2007). Marketershave heavily relied on celebrity endorsement, because they believe in its positive impact ofassisting in improvement of brand awareness, brand equity, and even financial returns.Celebrities are easily chosen by marketers to peddle th...

  19. The effect of leadership charisma, engagement and group belonging on volunteer work performance: AKUT search and rescue association example

    OpenAIRE

    Ebru Caymaz; Fahri Erenel; Burak Gürer

    2013-01-01

    Leadership charisma, has been emphasized in terms of performance improvement by inspiring organization’s values and norms and making employees spend extra effort for oganization’s objectives especially in hospitals and voluntary organizations (Choi, 2006; Etzioni, 1975; Grojean vd., 2004; Pillai ve Meindl, 1998; Shamir vd., 1993; Sims ve Brinkmann, 2002; Yammarino vd., 1993). In previous studies emphasis was usually on the effects of leadership charisma on work performance. Studies in Turkey ...

  20. Adaptability in Coalition Teamwork: Leader and Team Adaptability in Multi-National Coalitions (LTAMC) (Adaptabilite dans le travail d’equipe en Coalition: Adaptabilite des chefs et des equipes dans les coalitions multinationales)

    Science.gov (United States)

    2012-11-01

    They were Dr. David Matsumoto (editor of the International Journal of Cross - Cultural Psychology ;) and Dr. Mansour Javidan (co-author of the famous...ICIAI). Journal of Cross - Cultural Psychology , 28, 743-767. [58] Matsumoto , D., LeRoux, J.A., Iwamoto, M., Choi, J.W., Rogers, D., Tatani, H. and...differentiation. Journal of Cross - Cultural Psychology , 38, 413 – 431. [6] Matsumoto , D., Weissman, M., Preston, K., Brown, B. and Kupperbusch, C. (1997

  1. The Navy’s Superior Supplier Incentive Program: Analysis of Supplier Proposed Benefits

    Science.gov (United States)

    2015-12-01

    rather than “short-term, easy, expendable and replaceable sources of goods and services” (Carter & Choi, 2008, p. 2). Japanese automakers Toyota ...was the key element behind Toyota and Honda’s strategic successes. Under the supplier keiretsu, the automakers worked closely with the selected...suppliers to achieve mutually beneficial objectives. Toyota and Honda implemented the keiretsu model in their North American plants and achieved

  2. Epigenetic Control of Prostate Cancer Metastasis: Role of Runx2 Phosphorylation

    Science.gov (United States)

    2015-05-01

    buffered saline was injected into each mouse and the luminescence signal was captured on an IVIS Spectrum instrument (Perkin Elmer, Waltham, MA...Yun SJ, Yoon HY, Bae SC, Lee OJ, Choi YH, Moon SK et a/. Transcriptional repression of RUNX2 is associated with aggressive clinicopathological...Eur J lrnrnuno/ 2012; 42: 1044 1050. 42 Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW et a/. Src kinase phos phorylates RUNX3 at tyrosine

  3. Development of a Computational Assay for the Estrogen Receptor

    Science.gov (United States)

    2006-07-01

    Research in Undergraduate Computational Chemistry across New York and New England" at the Executive Summit, Delivering Technology Leadership for Life...Sciences: Research Advances for Drug Discovery and Bioterrorism. A Life Sciences Executive Summit co-sponsored by SGI, the Delaware Biotechnology...Bharath, J.; Jain, S.; Pham, H. B.; Boonyasiriwat, C.; Nguyen, N.; Andersen, E.; Kim, Y.; Choc , S.; Choi, J.; Cheatham, T. E.; Facelli, J. C. J. Chemical

  4. The Land Value Tax in Jamaica:An Analysis and Options for Reform

    OpenAIRE

    David L. Sjoquist

    2004-01-01

    This Working Paper on the property tax contains an Executive Summary and four chapters. In Chapter One we describe how the Jamaican property tax functions. In Chapter Two we present an analysis of various problems and issues that surround of the property tax. Chapter Three, which was co-authored with Ki-Whan Choi, presents an analysis of a land value tax versus a capital value tax. Finally, in Chapter Four we present options for reform.

  5. Effects of tai chi qigong on psychosocial well-being among hidden elderly, using elderly neighborhood volunteer approach: a pilot randomized controlled trial

    OpenAIRE

    Chan,Aileen; Yu,Doris; Choi,Kai

    2017-01-01

    Aileen WK Chan, Doris SF Yu, KC Choi The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Purpose: To test the feasibility and preliminary effectiveness of a tai chi qigong program with the assistance of elderly neighborhood volunteers in strengthening social networks and enhancing the psychosocial well-being of hidden elderly. Patients and methods: “Hidden elderly” is a term used to describe older adults w...

  6. Eliciting Naturalistic Cortical Responses with a Sensory Prosthesis via Optimized Microstimulation

    Science.gov (United States)

    2016-08-12

    Eliciting naturalistic cortical responses with a sensory prosthesis via optimized microstimulation John S Choi1, Austin J Brockmeier2, David B...applied to single electrodes in the ventral caudal thalamus evoke percepts that are both place and modality-specific, and yet ‘unnatural’ in feeling ...information on touch parameters, they do so with the same timing, as would be expected for a biomimetic sensory prosthesis . The discriminability of natural

  7. Non-parametric estimation of the individual's utility map

    OpenAIRE

    Noguchi, Takao; Sanborn, Adam N.; Stewart, Neil

    2013-01-01

    Models of risky choice have attracted much attention in behavioural economics. Previous research has repeatedly demonstrated that individuals' choices are not well explained by expected utility theory, and a number of alternative models have been examined using carefully selected sets of choice alternatives. The model performance however, can depend on which choice alternatives are being tested. Here we develop a non-parametric method for estimating the utility map over the wide range of choi...

  8. Choice Of Exchange Rate Regimes For Developing Countries: Better Be Fixed Or Floating?

    OpenAIRE

    Elif O. Kan

    2011-01-01

    The following paper is a summary article about the choice of exchange rate regime for a developing country considering the importance of currency mismatches, debt intolerance, and fear of floating, financial globalization, institutions and sudden stops. In this paper, I first summarize recent researches and papers on this specific issue. In a recent work of theirs, Calvo and Mishkin(2003) argue that much of the debate on choosing an exchange rate regime misses the boat and concludes that choi...

  9. Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

    OpenAIRE

    Han, Jae Woong; Gurunathan, Sangiliyandi; Choi, Yun-Jung; Kim, Jin-Hoi

    2017-01-01

    Jae Woong Han, Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul, Republic of Korea Background: Silver nanoparticles (AgNPs) exhibit strong antibacterial and anticancer activity owing to their large surface-to-volume ratios and crystallographic surface structure. Owing to their various applications, understanding the mechanisms of action, biological interactions, potential...

  10. Ultra-Sensitive Biological Detection via Nanoparticle-Based Magnetically Amplified Surface Plasmon Resonance (Mag-SPR) Techniques

    Science.gov (United States)

    2008-10-08

    surfactant such as hexadecyltrimethyl ammonium bromide (CTMA). And also CTMA- polymethacrylic acid (PMA), CTMA-Polyglutamic acid were synthesized as reference...rich world of naturally occurring biomaterials probably none is more important and more fundamental than DNA (deoxyribonucleic acid ), the polymeric...deoxyribonucleic acid gate dielectric," Journal of Applied Physics, vol. 100, p. 024514, 2006. [3] C. H. Lee, E.-D. Do, Y.-W. Kwon, D.-H. Choi, J.-I. Jin

  11. Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome

    OpenAIRE

    Yang, Young-Mo; Choi, Eun Joo

    2015-01-01

    Young-Mo Yang, Eun Joo Choi College of Pharmacy, Chosun University, Gwangju, South Korea Background: Polycystic ovary syndrome (PCOS) is an endocrinopathy that affects approximately 10% of reproductive-aged women throughout their lives. Women with PCOS present with heterogeneous symptoms including ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. Therefore, lifelong individualized management should be considered. Pharmacological agents commonly used to manage the symptoms are...

  12. Fitting Markovian binary trees using global and individual demographic data

    OpenAIRE

    Hautphenne, Sophie; Massaro, Melanie; Turner, Katharine

    2017-01-01

    We consider a class of branching processes called Markovian binary trees, in which the individuals lifetime and reproduction epochs are modeled using a transient Markovian arrival process (TMAP). We estimate the parameters of the TMAP based on population data containing information on age-specific fertility and mortality rates. Depending on the degree of detail of the available data, a weighted non-linear regression method or a maximum likelihood method is applied. We discuss the optimal choi...

  13. Design Sensitivity Method for Sampling-Based RBDO with Fixed COV

    Science.gov (United States)

    2015-04-29

    contours of the input model at initial design d0 and RBDO optimum design dopt are shown. As the limit state functions are not linear and some input...Glasser, M. L., Moore, R. A., and Scott, T. C., 1990, "Evaluation of Classes of Definite Integrals Involving Elementary Functions via...Differentiation of Special Functions," Applicable Algebra in Engineering, Communication and Computing, 1(2), pp. 149-165. [25] Cho, H., Bae, S., Choi, K. K

  14. Some Connections between the Spherical and Parabolic Bases on the Cone Expressed in terms of the Macdonald Function

    OpenAIRE

    Shilin, I. A.; Choi, Junesang

    2014-01-01

    Computing the matrix elements of the linear operator, which transforms the spherical basis of $SO(3,1)$ -representation space into the hyperbolic basis, very recently, Shilin and Choi (2013) presented an integral formula involving the product of two Legendre functions of the first kind expressed in terms of ${ }_{4}{F}_{3}$ -hypergeometric function and, using the general Mehler-Fock transform, another integral formula for the Legendre function of the first kind. In the sequel, we investigate ...

  15. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 58; Issue 5-6. Polarized Raman scattering in single crystals of Nd0.7Sr0.3MnO3. M Pattabiraman G Rangarajan Kwang-Yong Choi P Lemmens G Guentherodt G Balakrishnan D McK Paul M R Less. Colossal Magnetoresistance & Other Materials Volume 58 Issue 5-6 ...

  16. Integrated Intelligence: Robot Instruction via Interactive Grounded Learning

    Science.gov (United States)

    2016-02-14

    Choi, Yoav Artzi, Luke Zettlemoyer. Scaling Semantic Parsers with On-the- fly Ontology Matching, Emperical Methods in Natural Langauge Processing...estimating posterior distributions over hierarchies. When new answers become available, these distributions are updated efficiently using a sampling ...unveil confusion of non-experts over concepts, such as whether tomato is a fruit or vegetable, or whether the wrist is part of a person’s arm or hand. We

  17. Regressing Atherosclerosis by Resolving Plaque Inflammation

    Science.gov (United States)

    2017-07-01

    of Cardiology, Mount Sinai School of Medicine, New York, New York, USA. 3Department of Biomedical Sciences and School of Electrical Engineering and...Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, MA 02115, USA Dr. S. Jon KAIST Institute for the...Choi Center for Convergence Bioceramic Materials, Convergence R&D Division, Korea Institute of Ceramic Engineering and Technology, 202

  18. Effect of selenium-enriched organic material amendment on selenium fraction transformation and bioavailability in soil.

    Science.gov (United States)

    Wang, Dan; Dinh, Quang Toan; Anh Thu, Tran Thi; Zhou, Fei; Yang, Wenxiao; Wang, Mengke; Song, Weiwei; Liang, Dongli

    2018-05-01

    To exploit the plant byproducts from selenium (Se) biofortification and reduce environmental risk of inorganic Se fertilizer, pot experiment was conducted in this study. The effects of Se-enriched wheat (Triticum aestivum L.) straw (WS + Se) and pak choi (Brassica chinensis L.) (P + Se) amendment on organo-selenium speciation transformation in soil and its bioavailability was evaluated by pak choi uptake. The Se contents of the cultivated pak choi in treatments amended with the same amount of Se-enriched wheat straw and pak choi were 1.7 and 9.7 times in the shoots and 2.3 and 6.3 times in the roots compared with control treatment. Soil respiration rate was significantly increased after all organic material amendment in soil (p organic materials and thus resulted in soluble Se (SOL-Se), exchangeable Se (EX-Se), and fulvic acid-bound Se (FA-Se) fraction increasing by 25.2-29.2%, 9-13.8%, and 4.92-8.28%, respectively. In addition, both Pearson correlation and cluster analysis showed that EX-Se and FA-Se were better indicators for soil Se availability in organic material amendment soils. The Marquardt-Levenberg Model well described the dynamic kinetics of FA-Se content after Se-enriched organic material amendment in soil mainly because of the mineralization of organic carbon and organo-selenium. The utilization of Se in P + Se treatment was significantly higher than those in WS + Se treatment because of the different mineralization rates and the amount of FA-Se in soil. Se-enriched organic materials amendment can not only increase the availability of selenium in soil but also avoid the waste of valuable Se source. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Quantitative trait loci for rice yield-related traits using recombinant ...

    Indian Academy of Sciences (India)

    2011-08-19

    Aug 19, 2011 ... lated by map-based cloning strategy (Ashikari et al. 2005). ... 2000; Kojima et al. 2002; Doi et al. 2004). ... and PH but also on rice yield (Xue et al. 2008; Yan et al. ..... Cho Y. C., Suh J. P., Choi I. S., Hong H. C., Baek M. K., Kang K. H. et al. .... Yan C. J., Liang G. H., Chen F., Li X., Tang S. Z., Yi C. D. et al.

  20. Effects of Different Organic Materials and Exogenous Zn on Zn Distribution in Soil

    OpenAIRE

    HAO Jia-li; BU Yu-shan; JIA Zheng-rong; XI Ji-long; YAO Jing-zhen; DUAN Chao

    2015-01-01

    A pot experiment with a complete combinatorial design of two factors was conducted to study the effects of different organic materials and different concentrations of exogenous zinc on the soil total zinc, available zinc, zinc forms and zinc content distribution of pak-choi. The results showed that the total zinc, available zinc, and different forms of zinc contents in soil all increased as the concentration of exogenous zinc increased. Both lawn grass and maize straw decreased the total zinc...

  1. Phytochemical phenolics in organically grown vegetables.

    Science.gov (United States)

    Young, Janice E; Zhao, Xin; Carey, Edward E; Welti, Ruth; Yang, Shie-Shien; Wang, Weiqun

    2005-12-01

    Fruit and vegetable intake is inversely correlated with risks for several chronic diseases in humans. Phytochemicals, and in particular, phenolic compounds, present in plant foods may be partly responsible for these health benefits through a variety of mechanisms. Since environmental factors play a role in a plant's production of secondary metabolites, it was hypothesized that an organic agricultural production system would increase phenolic levels. Cultivars of leaf lettuce, collards, and pac choi were grown either on organically certified plots or on adjacent conventional plots. Nine prominent phenolic agents were quantified by HPLC, including phenolic acids (e. g. caffeic acid and gallic acid) and aglycone or glycoside flavonoids (e. g. apigenin, kaempferol, luteolin, and quercetin). Statistically, we did not find significant higher levels of phenolic agents in lettuce and collard samples grown organically. The total phenolic content of organic pac choi samples as measured by the Folin-Ciocalteu assay, however, was significantly higher than conventional samples (p lettuce and collards, the organic system provided an increased opportunity for insect attack, resulting in a higher level of total phenolic agents in pac choi.

  2. Inferring clocks when lacking rocks: the variable rates of molecular evolution in bacteria

    Directory of Open Access Journals (Sweden)

    Ochman Howard

    2009-09-01

    Full Text Available Abstract Background Because bacteria do not have a robust fossil record, attempts to infer the timing of events in their evolutionary history requires comparisons of molecular sequences. This use of molecular clocks is based on the assumptions that substitution rates for homologous genes or sites are fairly constant through time and across taxa. Violation of these conditions can lead to erroneous inferences and result in estimates that are off by orders of magnitude. In this study, we examine the consistency of substitution rates among a set of conserved genes in diverse bacterial lineages, and address the questions regarding the validity of molecular dating. Results By examining the evolution of 16S rRNA gene in obligate endosymbionts, which can be calibrated by the fossil record of their hosts, we found that the rates are consistent within a clade but varied widely across different bacterial lineages. Genome-wide estimates of nonsynonymous and synonymous substitutions suggest that these two measures are highly variable in their rates across bacterial taxa. Genetic drift plays a fundamental role in determining the accumulation of substitutions in 16S rRNA genes and at nonsynonymous sites. Moreover, divergence estimates based on a set of universally conserved protein-coding genes also exhibit low correspondence to those based on 16S rRNA genes. Conclusion Our results document a wide range of substitution rates across genes and bacterial taxa. This high level of variation cautions against the assumption of a universal molecular clock for inferring divergence times in bacteria. However, by applying relative-rate tests to homologous genes, it is possible to derive reliable local clocks that can be used to calibrate bacterial evolution. Reviewers This article was reviewed by Adam Eyre-Walker, Simonetta Gribaldo and Tal Pupko (nominated by Dan Graur.

  3. Viable tumor volume: Volume of interest within segmented metastatic lesions, a pilot study of proposed computed tomography response criteria for urothelial cancer

    International Nuclear Information System (INIS)

    Folio, Les Roger; Turkbey, Evrim B.; Steinberg, Seth M.; Apolo, Andrea B.

    2015-01-01

    Highlights: • It is clear that 2D axial measurements are incomplete assessments in metastatic disease; especially in light of evolving antiangiogenic therapies that can result in tumor necrosis. • Our pilot study demonstrates that taking volumetric density into account can better predict overall survival when compared to RECIST, volumetric size, MASS and Choi. • Although volumetric segmentation and further density analysis may not yet be feasible within routine workflows, the authors believe that technology advances may soon make this possible. - Abstract: Objectives: To evaluate the ability of new computed tomography (CT) response criteria for solid tumors such as urothelial cancer (VTV; viable tumor volume) to predict overall survival (OS) in patients with metastatic bladder cancer treated with cabozantinib. Materials and methods: We compared the relative capabilities of VTV, RECIST, MASS (morphology, attenuation, size, and structure), and Choi criteria, as well as volume measurements, to predict OS using serial follow-up contrast-enhanced CT exams in patients with metastatic urothelial carcinoma. Kaplan–Meier curves and 2-tailed log-rank tests compared OS based on early RECIST 1.1 response against each of the other criteria. A Cox proportional hazards model assessed response at follow-up exams as a time-varying covariate for OS. Results: We assessed 141 lesions in 55CT scans from 17 patients with urothelial metastasis, comparing VTV, RECIST, MASS, and Choi criteria, and volumetric measurements, for response assessment. Median follow-up was 4.5 months, range was 2–14 months. Only the VTV criteria demonstrated a statistical association with OS (p = 0.019; median OS 9.7 vs. 3.5 months). Conclusion: This pilot study suggests that VTV is a promising tool for assessing tumor response and predicting OS, using criteria that incorporate tumor volume and density in patients receiving antiangiogenic therapy for urothelial cancer. Larger studies are warranted to

  4. On superactivation of one-shot quantum zero-error capacity and the related property of quantum measurements

    DEFF Research Database (Denmark)

    Shirokov, M. E.; Shulman, Tatiana

    2014-01-01

    We give a detailed description of a low-dimensional quantum channel (input dimension 4, Choi rank 3) demonstrating the symmetric form of superactivation of one-shot quantum zero-error capacity. This property means appearance of a noiseless (perfectly reversible) subchannel in the tensor square...... of a channel having no noiseless subchannels. Then we describe a quantum channel with an arbitrary given level of symmetric superactivation (including the infinite value). We also show that superactivation of one-shot quantum zero-error capacity of a channel can be reformulated in terms of quantum measurement...

  5. Toward Development of a Field-Deployable Imaging Device for TBI

    Science.gov (United States)

    2015-06-01

    5] J.M. Seelig, D.P. Becker, J.D. Miller, R.P. Greenberg, J.D. Ward, S.C. Choi, Traumatic acute subdural hematoma : major mortality reduction in...the field. This results in a delay in quantifi- cation of the type and extent of TBI – epidural, subdural , versus intra-parenchymal bleeds; diffuse...example, surgical evacuation of epidural and subdural bleeds within hours of TBI immediately reduces the chance of exposure of brain to blood products

  6. Catalytic Activity and Structure Properties of Doped VOHPO4 ·0.5H2O with Nanosized Ru, Au, Fe and Mn in Benzene Hydroxylation

    CSIR Research Space (South Africa)

    Makgwane, PR

    2013-01-01

    Full Text Available . Taufiq-Yap, S. Nor Asrina, G. J. Hutchings, N. F. Dummer, and J. K. Bartley, J. Natural Gas 162, 31 (1996). 26. M. Choi, C. Han, I. T. Kim, J. C. An, J. J. Lee, H. K. Lee, and J. Shim, J. Nanosci. Nanotechnol. 11, 838 (2011). 27. K. Ki-Joong, S. Jae-Koon.... Today 111, 22 (2006). 35. R. Tanner, P. Gill, R. Wells, J. E. Bailie, G. Kelly, S. D. Jackson, and G. J. Hutchings, Phys. Chem. Chem. Phys. 2, 688 (2002). 36. C.-C. Yang, Y.-J. Lee, and J. M. Yang, J. Power Sources 188, 30 (2009). Received: 31 October...

  7. ANALISIS PENGARUH PERSEPSI MAHASISWA PADA UNSUR-UNSUR BAURAN PEMASARAN TERHADAP KEPUTUSAN MAHASISWA MEMILIH PERGURUAN TINGGI IPWIJA PROGRAM S2 (PASCA SARJANA)

    OpenAIRE

    Ismanto, Juli

    2017-01-01

    The development of the university or college that exist today provide clear evidence that the benefits of their education services not only enjoyed or felt by dealing directly with education services, but also enjoyed by all members of society. Selecting a part of the decision-making process (decision making).Impact determination of choice will be a good influence in the short term and the long term, either in the form of benefits and risks that must be borne. Moreover, the establishment choi...

  8. Reconstructing the Prostate Cancer Transcriptional Regulatory Network

    Science.gov (United States)

    2010-09-01

    and disease prognosis. J Clin Oncol 2006;24:3763–70. 13. Klein CA, Schmidt- Kittler O, Schardt JA, Pantel K, Speicher MR, Riethmuller G. Comparative...Cancer Gene Discovery Jessica Kao1., Keyan Salari1,2., Melanie Bocanegra1, Yoon-La Choi1,3, Luc Girard4, Jeet Gandhi4, Kevin A. Kwei1, Tina Hernandez...JM, Klein RC, Oka M, Cowan KH (1995) Posttranscriptional regulation of the c-myb proto-oncogene in estrogen receptor-positive breast cancer cells

  9. Pratiques sociales en formation à distance

    Directory of Open Access Journals (Sweden)

    Clément Dussarps

    2015-10-01

    Full Text Available L’abandon en formation ouverte et à distance (FOAD constitue un enjeu important tant pour les apprenants que pour les organismes de formation, que ce soit pour des raisons économiques, sociales, ou encore d’image de soi ou publique (Sauvé, 2012. L’un des éléments clés de l’abandon semble être la solitude vécue par les apprenants (Glikman, 2002, p. 242. Ce sentiment de solitude et l’abandon semblent peu dépendants de facteurs socio-démographiques (sexe, âge, etc. (Park et Choi, 2009. Face...

  10. A Panel Cointegration Analysis: Thailand’s International Tourism Demand Model

    OpenAIRE

    Prasert Chaitip; Chukiat Chaiboonsri

    2009-01-01

    This paper sought to find the long-run relationships between international tourist arrivals in Thailand and economic variables such as GDP, cost of transportation and exchange rates for the period 1986 to 2007. Also this paper used five standard panel unit root tests such as LLC (2002) panel unit root test, Breitung (2000) panel unit root test, IPS (2003) panel unit root test, Maddala and Wu (1999), Choi (2001) panel unit root test, Handri (1999) panel unit root test. Moreover, the panel coin...

  11. Characterization of a novel yeast species Metschnikowia persimmonesis KCTC 12991BP (KIOM G15050 type strain) isolated from a medicinal plant, Korean persimmon calyx (Diospyros kaki Thumb)

    OpenAIRE

    Kang, Young Min; Choi, Ji Eun; Komakech, Richard; Park, Jeong Hwan; Kim, Dae Wook; Cho, Kye Man; Kang, Seung Mi; Choi, Sang Haeng; Song, Kun Chul; Ryu, Chung Min; Lee, Keun Chul; Lee, Jung-Sook

    2017-01-01

    The yeast strain Metschnikowia persimmonesis Kang and Choi et al., sp. nov. [type strain KIOM_G15050 = Korean Collection for Type Cultures (KCTC) 12991BP] was isolated from the stalk of native persimmon cultivars (Diospyros kaki Thumb) obtained from different regions of South Korea and was characterized phenotypically, genetically, and physiologically. The isolate grew between 4 and 40 °C (optimum temperature: 24–28 °C), pH 3–8 (pH optimum = 6.0), and in 0–4% NaCl solution (with optimal growt...

  12. Seamless Integration of Detection and Therapy for Breast Cancer using Targeted Engineered Nanoparticles

    Science.gov (United States)

    2008-06-01

    SERS Signal Reporters," Anal. Chem. (2006). 19. Choi, M.-R.; Stanton-Maxey, K. J.; Stanley, J. K.; Levin, C. S.; Bardhan , R.; Akin, D.; Badve, S... Bardhan , R.; Akin, D.; Badve, S.; Sturgis, J.; Robinson, J. P.; Bashir, R.; Halas, N. J.; Clare, S. E. A Cellular Trojan Horse for Delivery of...Stanton-Maxey,† Jennifer K. Stanley,† Carly S. Levin,‡,§ Rizia Bardhan ,‡,§ Demir Akin,| Sunil Badve,⊥ Jennifer Sturgis,# J. Paul Robinson,# Rashid

  13. Mechanical Characterization of Anion Exchange Membranes Under Controlled Environmental Conditions

    Science.gov (United States)

    2015-05-11

    little market penetration has been achieved. Proton exchange membrane fuel cells ( PEMFC ) have struggled primarily due to high cost, driven by the use...and requirements for Pt, Pt-alloy, and non-Pt oxygen reduction catalysts for PEMFCs , Appl. Catal. B Environ. 56 (2005) 9–35. doi:10.1016/j.apcatb...resins for PEMFCs , Electrochim. Acta. 50 (2004) 571–575. doi:10.1016/j.electacta.2004.01.133. [89] S. Bhadra, N.H. Kim, J.S. Choi, K.Y. Rhee, J.H. Lee

  14. Measurement and Modeling of Ecosystem Risk and Recovery for In Situ Treatment of Contaminated Sediments. Phase 3

    Science.gov (United States)

    2015-08-01

    TITLE AND SUBTITLE Measurement and Modeling of Ecosystem Risk and Recovery for In Sit T t t f C t i t d S di t 5a. CONTRACT NUMBER W912HQ-10-C...Choi was supported in part by a Samsung Scholarship. Collaboration with Newcastle University was facilitated by the Leverhulme Trust, grant FOO 125/AA...and nitrogen deposited on porous alumina 4.2 147.6 Weak Preliminary tests to check the recovery of the selected CCMP from sediment was

  15. Quantum Partial Searching Algorithm of a Database with Several Target Items

    International Nuclear Information System (INIS)

    Pu-Cha, Zhong; Wan-Su, Bao; Yun, Wei

    2009-01-01

    Choi and Korepin [Quantum Information Processing 6(2007)243] presented a quantum partial search algorithm of a database with several target items which can find a target block quickly when each target block contains the same number of target items. Actually, the number of target items in each target block is arbitrary. Aiming at this case, we give a condition to guarantee performance of the partial search algorithm to be performed and the number of queries to oracle of the algorithm to be minimized. In addition, by further numerical computing we come to the conclusion that the more uniform the distribution of target items, the smaller the number of queries

  16. Error signals driving locomotor adaptation

    DEFF Research Database (Denmark)

    Choi, Julia T; Jensen, Peter; Nielsen, Jens Bo

    2016-01-01

    Locomotor patterns must be adapted to external forces encountered during daily activities. The contribution of different sensory inputs to detecting perturbations and adapting movements during walking is unclear. Here we examined the role of cutaneous feedback in adapting walking patterns to force...... walking (Choi et al. 2013). Sensory tests were performed to measure cutaneous touch threshold and perceptual threshold of force perturbations. Ankle movement were measured while subjects walked on the treadmill over three periods: baseline (1 min), adaptation (1 min) and post-adaptation (3 min). Subjects...

  17. Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers

    OpenAIRE

    Oh, Minkyung; Park, Sung-Eun; Ghim, Jong-Lyul; Choi, Young-Kyung; Shim, Eon-Jeong; Shin, Jae-Gook; Kim, Eun-Young

    2017-01-01

    Minkyung Oh,1,2,* Sung-Eun Park,3,* Jong-Lyul Ghim,1–3 Young-Kyung Choi,1 Eon-Jeong Shim,1–3 Jae-Gook Shin,1–3 Eun-Young Kim1–3 1Department of Pharmacology, 2PharmacoGenomics Research Center, Inje University College of Medicine, Busan, 3Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea *These authors contributed equally to this work Objective: This study compared the pharmacokinetic (PK) and safety pro...

  18. Electric Power Research in 1991

    International Nuclear Information System (INIS)

    1991-05-01

    This book of contents are a study of desalination by Kim, Young Bu, a study on efficiency test for nuclear power security by Jo, Sung Je; Ann, Nam Sung; Kim, Ho Gi, augmentation of EMS and RYU by Jung, Tae Hoe; Shin, Young Chuel, research on application for electric cars by Yu, Ann Gue, practical use oft robot for nuclear industry by Woo, He Gone; Shin, Hen Beom, a study on the characteristics of coolant structure in generator by Choi, Beng Hwan; Song, Young Chel; Kim, Jong Hark, and research of penetration rate of appliances by Park, Hong Ho; Kim, Beng Cheal; Kim, Dong Hwen.

  19. Magnetothermopower in unconventional density waves

    International Nuclear Information System (INIS)

    Dora, B.; Maki, K.; Vanyolos, A.; Virosztek, A.

    2003-10-01

    After a brief introduction on unconventional density waves (i.e. unconventional charge density wave (UCDW) and unconventional spin density wave (USDW)), we discuss the magnetotransport of the low temperature phase (LTP) of α-(BEDT-TTF) 2 KHg(SCN) 4 . Recently we have proposed that the low temperature phase in α-(BEDT-TTF) 2 KHg(SCN 4 should be UCDW. Here we show that UCDW describes very consistently the magnetothermopower of )α-(BEDT-TTF) 2 KHg(SCN) 4 observed by Choi et al. (author)

  20. United States Army Medical Department Journal. Leadership in the Army Medical Department, October - December 2009

    Science.gov (United States)

    2009-12-01

    growth following the gap is the grandchildren of the baby boomers known as generation Y , or millennial . The rise in the birth rate is noticeable in...M. Healthy design. Lancet. 2004;364:405-406. 13. Urich RS, Zimring CM, Zhu X, Dubose J, Seo H, Choi Y , et al. A review of the literature on...origin or background, from Latin ethnicus (nation, people). Religion \\ri-’li-J3n\\ a personal set or institutionalized system of attitudes, beliefs, and

  1. Analysis of the static yield stress for giant electrorheological fluids

    Science.gov (United States)

    Seo, Youngwook P.; Choi, Hyoung Jin; Seo, Yongsok

    2017-08-01

    Cheng et al. (2010)'s experimental results for the static yield stress of giant electrorheological (GER) fluids over the full range of electric field strengths were reanalyzed by applying Seo's scaling function which could include both the polarization and the conductivity models. The Seo's scaling function could correctly fit the yield stress behavior of GER suspensions behavior after if a proper normalization of the yield stress data was taken which collapse them onto a single curve. The model predictions were also contrasted with recently proposed Choi et al.'s scaling function to rouse the attention for a proper consideration of the GER fluid mechanisms.

  2. Analysis of giant electrorheological fluids.

    Science.gov (United States)

    Seo, Youngwook P; Seo, Yongsok

    2013-07-15

    The yield stress dependence on electric field strength for giant electrorheological (GER) fluids over the full range of electric fields was examined using Seo's scaling function which incorporated both the polarization and the conductivity models. If a proper scaling was applied to the yield stress data to collapse them onto a single curve, the Seo's scaling function could correctly fit the yield stress behavior of GER suspensions, even at very high electric field strengths. The model predictions were also compared with recently proposed Choi et al.'s model to allow a consideration of the universal framework of ER fluids. Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Multifunctional Poly(2,5-benzimidazole)/Carbon Nanotube Composite Films

    Science.gov (United States)

    2010-01-01

    Multifunctional Poly(2,5- benzimidazole )/Carbon Nanotube Composite Films JI-YE KANG,1 SOO-MI EO,1 IN-YUP JEON,1 YEONG SUK CHOI,2 LOON-SENG TAN,3 JONG...molecular-weight poly(2,5- benzimidazole ) (ABPBI). ABPBI/carbon nanotube (CNT) compo- sites were prepared via in situ polymerization of the AB-monomer in the...polymerization; multiwalled carbon nanotube (MWCNT); nano- composites; poly(2,5- benzimidazole ); (ABPBI); polycondensa- tion; poly(phosphoric acid); single-walled

  4. Separability of three qubit Greenberger-Horne-Zeilinger diagonal states

    Science.gov (United States)

    Han, Kyung Hoon; Kye, Seung-Hyeok

    2017-04-01

    We characterize the separability of three qubit GHZ diagonal states in terms of entries. This enables us to check separability of GHZ diagonal states without decomposition into the sum of pure product states. In the course of discussion, we show that the necessary criterion of Gühne (2011 Entanglement criteria and full separability of multi-qubit quantum states Phys. Lett. A 375 406-10) for (full) separability of three qubit GHZ diagonal states is sufficient with a simpler formula. The main tool is to use entanglement witnesses which are tri-partite Choi matrices of positive bi-linear maps.

  5. Analysis of myo-inositol hexakisphosphate hydrolysis by Bacillus phytase

    DEFF Research Database (Denmark)

    Kerovuo, J.; Rouvinen, J.; Hatzack, Frank-Andreas

    2000-01-01

    Phytic acid (myo-inositol hexakisphosphate, InsP(6)) hydrolysis by Bacillus phytase (PhyC) was studied. The enzyme hydrolyses only three phosphates from phytic acid. Moreover, the enzyme seems to prefer the hydrolysis of every second phosphate over that of adjacent ones. Furthermore, it is very...... a reaction mechanism different from that of other phytases. By combining the data presented in this study with (1) structural information obtained from the crystal structure of Bacillus amyloliquefaciens phytase [Ha, Oh, Shin, Kim, Oh, Kim, Choi and Oh (2000) Nat. Struct. Biol. 7, 147-153], and (2) computer...

  6. Plasma control system for 'Day-One' operation of KSTAR tokamak

    International Nuclear Information System (INIS)

    Hahn, Sang-hee; Walker, M.L.; Kim, Kukhee; Ahn, H.S.; Penaflor, B.G.; Piglowski, D.A.; Johnson, R.D.; Choi, Jaehoon; Lee, Dong-keun; Kim, Jayhyun; Yoon, S.W.; Seo, Seong-Heon; Kim, H.T.; Kim, K.P.; Lee, T.G.; Park, M.K.; Bak, J.G.; Lee, S.G.; Nam, Y.U.; Eidietis, N.W.

    2009-01-01

    A complete plasma control system (PCS) has been developed for KSTAR's first plasma campaign as a collaborative project with the DIII-D team. The KSTAR real time plasma control system is based on a conceptual design by Jhang and Choi [Hogun Jhang, I.S. Choi, Fusion Engineering and Design 73 (2005) 35-49] and consists of a fast real-time computer/communication cluster and software derived from the GA-PCS [Penaflor, B.G., et.al., Fusion Engineering and Design, 83 (2) (2008) 176]. The system has been used for simulation testing, poloidal field (PF) coil power supply commissioning and first plasma control. The seven sets of up-down symmetric, superconducting PF coil/power supply systems have been successfully tested. Reflective memory (RFM) is utilized as the primary actuator/PCS real-time communication layer and PCS synchronization with KSTAR timing system and slower control devices is achieved through an EPICS implementation. Consistent feedback loop times of 100 microseconds has been achieved during PF coil power supply testing and first plasma commissioning. Here we present the 'Day-One' plasma control system in its final form for the first plasma experimental campaign of KSTAR and describe how the system has been utilized during magnet commissioning and plasma startup experiments.

  7. High-Resolution Infrared Spectroscopy of Imidazole Clusters in Helium Droplets Using Quantum Cascade Lasers

    Science.gov (United States)

    Mani, Devendra; Can, Cihad; Pal, Nitish; Schwaab, Gerhard; Havenith, Martina

    2017-06-01

    Imidazole ring is a part of many biologically important molecules and drugs. Imidazole monomer, dimer and its complexes with water have earlier been studied using infrared spectroscopy in helium droplets^{1,2} and molecular beams^{3}. These studies were focussed on the N-H and O-H stretch regions, covering the spectral region of 3200-3800 \\wn. We have extended the studies on imidazole clusters into the ring vibration region. The imidazole clusters were isolated in helium droplets and were probed using a combination of infrared spectroscopy and mass spectrometry. The spectra in the region of 1000-1100 \\wn and 1300-1460 \\wn were recorded using quantum cascade lasers. Some of the observed bands could be assigned to imidazole monomer and higher order imidazole clusters, using pickup curve analysis and ab initio calculations. Work is still in progress. The results will be discussed in detail in the talk. References: 1) M.Y. Choi and R.E. Miller, J. Phys. Chem. A, 110, 9344 (2006). 2) M.Y. Choi and R.E. Miller, Chem. Phys. Lett., 477, 276 (2009). 3) J. Zischang, J. J. Lee and M. Suhm, J. Chem. Phys., 135, 061102 (2011). Note: This work was supported by the Cluster of Excellence RESOLV (Ruhr-Universitat EXC1069) funded by the Deutsche Forschungsgemeinschaft.

  8. Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent.

    Science.gov (United States)

    Kapuścik, Aleksandra; Hrouzek, Pavel; Kuzma, Marek; Bártová, Simona; Novák, Petr; Jokela, Jouni; Pflüger, Maren; Eger, Andreas; Hundsberger, Harald; Kopecký, Jiří

    2013-11-25

    Aeruginosin-865 (Aer-865), isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety, and is the first aeruginosin to be found in the genus Nostoc. Mass spectrometry, chemical and spectroscopic analysis as well as one- and two-dimensional NMR and chiral HPLC analysis of Marfey derivatives were applied to determine the peptidic sequence: D-Hpla, D-Leu, 5-OH-Choi, Agma, with hexanoic and mannopyranosyl uronic acid moieties linked to Choi. We used an AlphaLISA assay to measure the levels of proinflammatory mediators IL-8 and ICAM-1 in hTNF-α-stimulated HLMVECs. Aer-865 showed significant reduction of both: with EC50 values of (3.5±1.5) μg mL(-1) ((4.0±1.7) μM) and (50.0±13.4) μg mL(-1) ((57.8±15.5) μM), respectively. Confocal laser scanning microscopy revealed that the anti-inflammatory effect of Aer-865 was directly associated with inhibition of NF-κB translocation to the nucleus. Moreover, Aer-865 did not show any cytotoxic effect. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Analysis of direct immobilized recombinant protein G on a gold surface

    International Nuclear Information System (INIS)

    Kim, Hyunhee; Kang, Da-Yeon; Goh, Hyun-Jeong; Oh, Byung-Keun; Singh, Ravindra P.; Oh, Soo-Min; Choi, Jeong-Woo

    2008-01-01

    Abstact: For the immobilization of IgG, various techniques such as chemical linker, thiolated protein G methods, and fragmentation of antibodies have been reported [Y.M. Bae, B.K. Oh, W. Lee, W.H. Lee, J.W. Choi, Biosensors Bioelectron. 21 (2005) 103; W. Lee, B.K. Oh, W.H. Lee, J.W. Choi, Colloids Surf. B-Biointerfaces, 40 (2005) 143; A.A. Karyakin, G.V. Presnova, M.Y. Rubtsova, A.M. Egorov, Anal. Chem. 72 (2000) 3805]. Here, we modified the immunoglobulin Fc-binding B-domain of protein G to contain two cysteine residues at its C-terminus by a genetic engineering technique. The resulting recombinant protein, RPGcys, retained IgG-binding activity in the same manner as native protein G. RPGcys was immobilized on a gold surface by strong affinity between thiol of cysteine and gold. The orientations of both IgG layers immobilized on the base recombinant protein Gs were analyzed by fluorescence microscope, atomic force microscope (AFM), and surface plasmon resonance (SPR). Our data revealed that IgG-binding activity of RPGcys on gold surface significantly increased in comparison to wild type of protein G (RPGwild), which was physically adsorbed due to absence of cysteine residue. Immobilization of highly oriented antibodies based on cysteine-modified protein G could be useful for the fabrication of immunosensor systems

  10. Turbulent Cloud Structure and Power Spectrum from 23 years of HST Observations

    Science.gov (United States)

    Cosentino, Richard; Simon, Amy; Morales-Juberias, Raul

    2018-01-01

    Images of Jupiter’s clouds show that turbulence is a ubiquitous phenomenon over many orders of scale size. According to Kolmogorov’s theory for turbulence, the frequency/distribution of clouds at various scales can be used to produce an energy power spectrum of a passive tracer. Kolmogorov theory predicts the spectral slopes for “shallow” and “deep” fluids in motion by following how energy is injected and dissipated in the fluid. We are quantifying the turbulent nature of Jupiter’s clouds over 23 years of Hubble Space Telescope (HST) observations using an algorithm first presented in Choi and Showman (2011, Icarus 216). We applied the power spectrum fitting algorithm to a variety of filters from available HST data and tested its sensitivity to free parameters and compare our results to Choi and Showman (2011). We will comment on the evidence for a 2D turbulent regime In Jupiter’s clouds and will report on empirical values found in the spectra and their physical interpretations, such as the Rhines scale. We also will report on the behavior of the passive tracer power spectrum and trends that exist over time for different latitudinal regions, primarily the belts and zones and the north and south equatorial belts.

  11. The effects of LED illumination spectra and intensity on carotenoid content in Brassicaceae microgreens.

    Science.gov (United States)

    Brazaitytė, Aušra; Sakalauskienė, Sandra; Samuolienė, Giedrė; Jankauskienė, Julė; Viršilė, Akvilė; Novičkovas, Algirdas; Sirtautas, Ramūnas; Miliauskienė, Jurga; Vaštakaitė, Viktorija; Dabašinskas, Laurynas; Duchovskis, Pavelas

    2015-04-15

    The objective of this study was to evaluate the effects of irradiance levels and spectra produced by solid-state light-emitting diodes (LEDs) on carotenoid content and composition changes in Brassicaceae microgreens. A system of five high-power, solid-state lighting modules with standard 447-, 638-, 665-, and 731-nm LEDs was used in the experiments. Two experiments were performed: (1) evaluation of LED irradiance levels of 545, 440, 330, 220, and 110 μmol m(-2) s(-1) photosynthetically active flux density (PPFD) and (2) evaluation of the effects of 520-, 595-, and 622-nm LEDs supplemental to the standard set of LEDs. Concentrations of various carotenoids in red pak choi and tatsoi were higher under illumination of 330-440 μmol m(-2) s(-1) and at 110-220 μmol m(-2) s(-1) in mustard. All supplemental wavelengths increased total carotenoid content in mustard but decreased it in red pak choi. Carotenoid content increased in tatsoi under supplemental yellow light. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Radiological evaluation of response to treatment: Application to metastatic renal cancers receiving anti-angiogenic treatment

    International Nuclear Information System (INIS)

    Ammari, S.; Hernigou, A.; Grataloup, C.; Thiam, R.; Cuenod, C.A.; Siauve, N.; Fournier, L.S.; Oudard, S.; Medioni, J.

    2014-01-01

    Targeted therapies have considerably improved the prognosis of patients with metastatic renal cancer (mRCC) but there are no reliable response assessment criteria reflecting the clinical benefits, because there is no regression in size, or it is delayed. Such criteria would help early identification of non-responders, who would then benefit from a change of treatment, and would avoid their being subjected to unnecessary side effects related to the treatment. We will review the imaging techniques currently available for evaluating tumour response in mRCC patients, including the response evaluation criteria in solid tumours (RECIST), the Choi criteria, the modified Choi criteria, and the CT size and attenuation criteria (SACT). We will also discuss functional imaging techniques, which are based on the physiological characteristics of the tumours, such as perfusion CT, magnetic resonance imaging or ultrasound (DCE-CT, DCE-MRI, DCE-US), diffusion MRI, BOLD MRI and new positron emission tomography (PET) tracers. It is not possible at present to propose a unanimously acknowledged criterion for evaluating tumour response to targeted therapy. However, there is a real need for this according to oncologists and the pharmaceutical industry, and radiologists need to be involved in reflecting on the subject. (authors)

  13. Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia

    Directory of Open Access Journals (Sweden)

    Simonetta Baldi

    2010-02-01

    Full Text Available Simonetta Baldi, Roberto Aquilani, Gian Domenico Pinna, Paolo Poggi, Angelo De Martini, Claudio BruschiDepartment of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I.R.C.C.S. Pavia, ItalyBackground: Fat-free mass (FFM depletion marks the imbalance between tissue protein synthesis and breakdown in chronic obstructive pulmonary disease (COPD. To date, the role of essential amino acid supplementation (EAAs in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation.Methods: 28 COPD patients with dynamic weight loss > 5% over the last 6 months were randomized to receive EAAs embedded in a 12-week rehabilitation program (EAAs group n = 14, or to the same program without supplementation (C group n = 14. Primary outcome measures were changes in body weight and FFM, using dual X-ray absorptiometry (DEXA.Results: At the 12th week, a body weight increment occurred in 92% and 15% of patients in the EAAs and C group, respectively, with an average increase of 3.8 ± 2.6 kg (P = 0.0002 and −0.1 ± 1.1 kg (P = 0.81, respectively. A FFM increment occurred in 69% and 15% of EAAs and C patients, respectively, with an average increase of 1.5 ± 2.6 kg (P = 0.05 and −0.1 ± 2.3 kg (P = 0.94, respectively. In the EAAs group, FFM change was significantly related to fasting insulin (r2 0.68, P < 0.0005, C-reactive protein (C-RP (r2 = 0.46, P < 0.01, and oxygen extraction tension (PaO2x (r2 = 0.46, P < 0.01 at end of treatment. These three variables were highly correlated in both groups (r > 0.7, P < 0.005 in all tests.Conclusions: Changes in FFM promoted by EAAs are related to cellular energy and tissue oxygen availability in depleted COPD. Insulin, C-RP, and PaO2x must be regarded as clinical markers of an amino acid-stimulated signaling to FFM accretion.Keywords: COPD, pulmonary rehabilitation, branched chain amino acids, insulin, systemic

  14. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

    Directory of Open Access Journals (Sweden)

    Ferrari F

    2011-04-01

    Full Text Available Flora Ferrari1, Simonetta Fiorentino1, Laura Mennuni1, Paolo Garofalo1, Ornella Letari1, Stefano Mandelli2, Antonio Giordani3, Marco Lanza1, Gianfranco Caselli11Department of Pharmacology and Toxicology; 2Department of Medicinal Chemistry; 3R&D Chemistry Drug Development and OS, Rottapharm S.p.A., Monza (MB, ItalyAbstract: Two decades of investigations have failed to unequivocally clarify the functions and the molecular nature of imidazoline-2 receptors (I2R. However, there is robust pharmacological evidence for the functional modulation of monoamino oxidase (MAO and other important enzyme activities by I2 site ligands. Some compounds of this class proved to be active experimental tools in preventing both experimental pain and opioid tolerance and dependence. Unfortunately, even though these compounds bind with high potency to central I2 sites, they fail to represent a valid clinical opportunity due to their pharmacokinetic, selectivity or side-effects profile. This paper presents the preclinical profile of a novel I2 ligand (2-phenyl-6-(1H-imidazol-1ylquinazoline; [CR4056] that selectively inhibits the activity of human recombinant MAO-A in a concentration-dependent manner. A sub-chronic four day oral treatment of CR4056 increased norepinephrine (NE tissue levels both in the rat cerebral cortex (63.1% ± 4.2%; P<0.05 and lumbar spinal cord (51.3% ± 6.7%; P < 0.05. In the complete Freund's adjuvant (CFA rat model of inflammatory pain, CR4056 was found to be orally active (ED50 = 5.8 mg/kg, by mouth [p.o.]. In the acute capsaicin model, CR4056 completely blocked mechanical hyperalgesia in the injured hind paw (ED50 = 4.1 mg/kg, p.o.; ED100 = 17.9 mg/kg, p.o.. This effect was dose-dependently antagonized by the non-selective imidazoline I2/α2 antagonist idazoxan. In rat models of neuropathic pain, oral administration of CR4056 significantly attenuated mechanical hyperalgesia and allodynia. In summary, the present study suggests a novel

  15. Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer

    Directory of Open Access Journals (Sweden)

    Susini T

    2014-11-01

    Full Text Available Tommaso Susini,1 Barbara Berti,1 Carlo Carriero,1 Ketty Tavella,2 Jacopo Nori,3 Ermanno Vanzi,3 Cecilia Molino,1 Mariarosaria Di Tommaso,1 Marco Santini,1 Valeria Saladino,4 Simonetta Bianchi4 1Department of Health Science, Gynecology Section, 2Department of Health Science, Chemotherapy Section, University of Florence, Italy; 3Diagnostic Senology Unit, Azienda Ospedaliera-Universitaria Careggi, Florence, Italy; 4Department of Surgery and Translational Medicine, Pathology Unit, University of Florence, Italy Purpose: Anthracyclines and taxanes are considered the standard for neoadjuvant chemotherapy of breast cancer, although they are often associated with serious side effects and wide variability of individual response. In this study, we analyzed the value of topoisomerase II alpha (TOP2A and transducin-like enhancer of split 3 (TLE3 as predictive markers of response to therapy with anthracyclines and taxanes. Materials and methods: TOP2A and TLE3 protein expressions were evaluated using immunohistochemistry on 28 samples, obtained by core needle biopsy in patients with locally advanced breast carcinoma, subsequently subjected to epirubicin- and paclitaxel-based neoadjuvant chemotherapy. The immunohistochemical staining was correlated with the clinical response measured by the tumor size reduction evaluated by breast magnetic resonance imaging, prior and after chemotherapy, and by pathologic evaluation of the surgical specimen. Results: Neoadjuvant chemotherapy achieved a size reduction in 26/28 tumors (92.9%, with an average percentage decrease of 45.6%. A downstaging was achieved in 71.4% of the cases of locally advanced carcinoma. TOP2A positivity was correlated with a greater reduction in tumor diameter (P=0.06; negative staining for TLE3 was predictive of a better response to neoadjuvant chemotherapy (P=0.07. A higher reduction in tumor diameter (P=0.03 was also found for tumors that were concurrently TLE3-negative and TOP2A

  16. In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization

    Directory of Open Access Journals (Sweden)

    Gelardi M

    2016-04-01

    Full Text Available Matteo Gelardi,1 Mariangela Bosoni,2 Marco Morelli,2 Silvia Beretta,2 Cristoforo Incorvaia,3 Serena Buttafava,4 Massimo Landi,5 Simonetta Masieri,6 Franco Frati,4 Nicola Quaranta,1 Gian Vincenzo Zuccotti21Otolaryngology Section, Department of Neuroscience and Sensory Organs, University of Bari, 2Department of Pediatrics, Luigi Sacco Hospital, University of Milan, 3Allergy/Pulmonary Rehabilitation Unit, ICP Hospital, 4Medical and Scientific Department, Stallergenes Italy, Milan, 5Department of Pediatrics, ASL TO1, Turin, 6Department of Otorhinolaryngology, Sapienza University of Rome, Rome, ItalyBackground: In patients polysensitized to pollen allergens, the priming effect, by which the sensitivity of the nasal mucosa to an allergen is increased by the previous exposure to another allergen, is a known phenomenon. This study was aimed at evaluating the degree of nasal inflammation, assessed by nasal cytology, in children with allergic rhinitis (AR from ragweed pollen according to being monosensitized or polysensitized.Methods: The study included 47 children. Of them, 24 suffered from AR caused by sensitization to grass pollen and ragweed pollen (group A and 23 were sensitized only to ragweed pollen (group B. In all patients, the severity of AR was assessed according to the Allergic Rhinitis and Its Impact on Asthma guidelines, and comorbidities were also evaluated.Results: In group A, 16.7% of children had a mild intermittent AR, 4.2% a moderate-to-severe intermittent, 33.3% a mild persistent, and 45.8% a moderate-to-severe persistent; in group B, 26.1% of children had a mild intermittent AR, 0% a moderate-to-severe intermittent, 52.2% a mild persistent, and 21.7% a moderate-to-severe persistent. No significant difference was detected in the number of the considered comorbidities between the two groups. The cell counts of neutrophils, eosinophils, lymphocytes/plasma cells, and mast cells were high but not significantly different in the two groups

  17. Medicinal clays improve the endurance of loaded inspiratory muscles in COPD: a randomized clinical trial of nonpharmacological treatment

    Directory of Open Access Journals (Sweden)

    Baldi S

    2015-10-01

    Full Text Available Simonetta Baldi,1 Gian Domenico Pinna,2 Claudio Bruschi,1 Fabrizio Caldara,3 Roberto Maestri,2 Elena Dacosto,1 Antonella Rezzani,1 Ermanno Popovich,1 Ezio Bellinzona,1 Paola Crotti,1 Silvia Montemartini,1 Claudio Fracchia1 1Department of Pneumology, 2Department of Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation, Istituto Di Ricovero e Cura a Carattere Scientifico, Montescano (Pavia, 3Center of Thermal Studies Pietro d’Abano, AbanoTerme, Padua, Italy Background: Inspiratory resistive breathing (IRB challenges affect respiratory muscle endurance in healthy individuals, which is considered to be an interleukin 6 (IL-6–dependent mechanism. Whether nonpharmacological thermal therapies promote the endurance of loaded inspiratory muscles in chronic obstructive pulmonary disease (COPD is unclear. The objectives of this study were to compare the effects of two thermal interventions on endurance time (ET and plasma IL-6 concentration following an IRB challenge.Methods: This study was a randomized, parallel-group, unblinded clinical trial in a single-center setting. Forty-two patients (aged 42–76 years suffering from mild to severe COPD participated in this study. Both groups completed 12 sessions of the mud bath therapy (MBT (n=22 or leisure thermal activity (LTA (n=19 in a thermal spa center in Italy. Pre- and postintervention spirometry, maximum inspiratory pressure, and plasma mediators were obtained and ET and endurance oxygen expenditure (VO2Endur were measured following IRB challenge at 40% of maximum inspiratory pressure.Results: There was no difference in ΔIL-6 between the intervention groups. But, IRB challenge increased cytokine IL-6 plasma levels systematically. The effect size was small. A statistically significant treatment by IRB challenge effect existed in ET, which significantly increased in the MBT group (P=0.003. In analysis of covariance treatment by IRB challenge analysis with LnVO2

  18. Latent class analysis on internet and smartphone addiction in college students

    Directory of Open Access Journals (Sweden)

    Mok JY

    2014-05-01

    Full Text Available Jung-Yeon Mok,1 Sam-Wook Choi,1,2 Dai-Jin Kim,3 Jung-Seok Choi,4 Jaewon Lee,2 Heejune Ahn,5 Eun-Jeung Choi,6 Won-Young Song7 1Eulji Addiction Institute, Eulji University, Seoul, South Korea; 2Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea; 3Department of Psychiatry, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea; 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea; 5Department of Electrical and Information Engineering, SeoulTech, Seoul, South Korea; 6Department of Social Welfare, Dongshin University, Naju, South Korea; 7Department of Counseling and Psychotherapy, Konyang University, Nonsan, South Korea Purpose: This study aimed to classify distinct subgroups of people who use both smartphone and the internet based on addiction severity levels. Additionally, how the classified groups differed in terms of sex and psychosocial traits was examined. Methods: A total of 448 university students (178 males and 270 females in Korea participated. The participants were given a set of questionnaires examining the severity of their internet and smartphone addictions, their mood, their anxiety, and their personality. Latent class analysis and ANOVA (analysis of variance were the statistical methods used. Results: Significant differences between males and females were found for most of the variables (all P<0.05. Specifically, in terms of internet usage, males were more addicted than females (P<0.05; however, regarding smartphone, this pattern was reversed (P<0.001. Due to these observed differences, classifications of the subjects into subgroups based on internet and smartphone addiction were performed separately for each sex. Each sex showed clear patterns with the three-class model based on likelihood level of internet and smartphone addiction (P<0.001. A common trend for psychosocial trait factors was found for both sexes: anxiety levels and

  19. Optimal unitary dilation for bosonic Gaussian channels

    International Nuclear Information System (INIS)

    Caruso, Filippo; Eisert, Jens; Giovannetti, Vittorio; Holevo, Alexander S.

    2011-01-01

    A general quantum channel can be represented in terms of a unitary interaction between the information-carrying system and a noisy environment. In this paper the minimal number of quantum Gaussian environmental modes required to provide a unitary dilation of a multimode bosonic Gaussian channel is analyzed for both pure and mixed environments. We compute this quantity in the case of pure environment corresponding to the Stinespring representation and give an improved estimate in the case of mixed environment. The computations rely, on one hand, on the properties of the generalized Choi-Jamiolkowski state and, on the other hand, on an explicit construction of the minimal dilation for arbitrary bosonic Gaussian channel. These results introduce a new quantity reflecting ''noisiness'' of bosonic Gaussian channels and can be applied to address some issues concerning transmission of information in continuous variables systems.

  20. Mathematical modeling and experimental study of polarization echo in optically anisotropic media

    Science.gov (United States)

    Bogdanov, Yu. I.; Kalinkin, A. A.; Kulik, S. P.; Moreva, E. V.; Shershulin, V. A.; Belinsky, L. V.

    2013-01-01

    As optical systems are one of the candidates for implementation of a scalable quantum computer, it is important to develop an adequate method of description of both quantum states of light and operations performed by optical elements. Using the concept of chi-matrix representation of quantum operations and Choi-Jamiolkowski isomorphism we expand Jones calculus to allow description of evolution of mixed polarization states in linear optical systems. The developed method is then used to give a full description of polarization echo effect, which was described in 1 based on an analogy between the effects of polarization optics and spin dynamics. Theoretical predictions are confirmed by reconstructing operations performed by a series of quartz waveplates using quantum process tomography protocols.

  1. Re: Penetration Behavior of Opposed Rows of Staggered Secondary Air Jets Depending on Jet Penetration Coefficient and Momentum Flux Ratio

    Science.gov (United States)

    Holdeman, James D.

    2016-01-01

    The purpose of this article is to explain why the extension of the previously published C = (S/Ho)sqrt(J) scaling for opposed rows of staggered jets wasn't directly successful in the study by Choi et al. (2016). It is not surprising that staggered jets from opposite sides do not pass each other at the expected C value, because Ho/D and sqrt(J) are much larger than the maximum in previous studies. These, and large x/D's, tend to suggest development of 2-dimensional flow. Although there are distinct optima for opposed rows of in-line jets, single-side injection, and opposed rows of staggered jets based on C, opposed rows of staggered jets provide as good or better mixing performance, at any C value, than opposed rows of in-line jets or jets from single-side injection.

  2. Clasificación de fallas en motores eléctricos utilizando señales de vibración

    OpenAIRE

    Arango Flórez, Gustavo Adolfo

    2007-01-01

    La tesis está encaminada a la aplicación de las técnicas tiempo frecuencia al análisis de senales de vibración para el diagnóstico de fallas en máquinas rotativas. Para esto se implementan métodos de extracción y clasificación de caracteristicas para lograr acercar de manera más precisa al diagnosticador a encontrar la causa raíz de la falla. Se realiza un estudio de cuatro métodos de extracción de características: Transformadas Wavelet, Distribución Wigner Ville, Distribución Choi Williams y...

  3. The effects of divided attention at study and test on false recognition: a comparison of DRM and categorized lists.

    Science.gov (United States)

    Knott, Lauren M; Dewhurst, Stephen A

    2007-12-01

    Three experiments investigated the effects of divided attention at encoding and retrieval on false recognition. In Experiment 1, participants studied word lists in either full or divided attention (random number generation) conditions and then took part in a recognition test with full attention. In Experiment 2, after studying word lists with full attention, participants carried out a recognition test with either full or divided attention. Experiment 3 manipulated attention at both study and test. We also compared Deese/Roediger-McDermott (DRM) and categorized lists, due to recent claims regarding the locus of false memories produced by such lists (Smith, Gerkens, Pierce, & Choi, 2002). With both list types, false "remember" responses were reduced by divided attention at encoding and increased by divided attention at retrieval. The findings suggest that the production of false memories occurs as a result of the generation of associates at encoding and failures of source monitoring retrieval. Crucially, this is true for both DRM and categorized lists.

  4. Use of quantitative methods in the study of cultural goods consumption in popular sectors within the city of Mexicali, B.C.

    Directory of Open Access Journals (Sweden)

    Luz María Ortega Villa

    2007-07-01

    Full Text Available In this work, a brief of the methodology used in the study of cultural goods consumption among popular sector of Mexicali is presented. It includes three phases: a survey (quantitative method, a typology established from a multivariate analysis (data mining, and interviews with selected type-cases (qualitative method all of which are analyzed from a multidimensional perspective whose categories retrieve marketing findings such as consumption visions (Phillips, Olson and Baumgartner, 1995 and conflict resolution strategies (Kwai-Choi and Collins, 2000 applied in the process of decision-making. It also draws from sociology (Thompson, 1990; Bourdieu, 1984 in order to identify reproductive aspects of consumption related to educative capital and social origin, and to deal with symbolic evaluation strategies of legitimate cultural goods.

  5. Silver nanoparticles decorated on a three-dimensional graphene scaffold for electrochemical applications

    CSIR Research Space (South Africa)

    Bello, A

    2014-01-01

    Full Text Available –87 [40] J. Lee, K. Novoselov, H. Shin, ACS Nano. 5 (2010) 608–612. [41] S.J. Chae, F. Güneş, K.K. Kim, E.S. Kim, G.H. Han, S.M. Kim, H.J. Shin, S. Yoon, J. Choi, M.H. Park, C.W. Yang, D. Pribat, Y.H. Lee, Adv. Mater. 21 (2009) 2328–2333. [42] L-R. Zhang....5 respectively. The low values could be attributed to the weak van der Waals interaction between Ag and graphene, which may change the structure of the graphene. The results here are similar to those obtained by Lee, Novoselov and Shin [40] who proposed...

  6. Adaptive estimation and discrimination of Holevo-Werner channels

    Directory of Open Access Journals (Sweden)

    Cope Thomas P. W.

    2017-12-01

    Full Text Available The class of quantum states known as Werner states have several interesting properties, which often serve to illuminate unusual properties of quantum information. Closely related to these states are the Holevo- Werner channels whose Choi matrices are Werner states. Exploiting the fact that these channels are teleportation covariant, and therefore simulable by teleportation, we compute the ultimate precision in the adaptive estimation of their channel-defining parameter. Similarly, we bound the minimum error probability affecting the adaptive discrimination of any two of these channels. In this case, we prove an analytical formula for the quantum Chernoff bound which also has a direct counterpart for the class of depolarizing channels. Our work exploits previous methods established in [Pirandola and Lupo, PRL 118, 100502 (2017] to set the metrological limits associated with this interesting class of quantum channels at any finite dimension.

  7. Application of a fast sorting algorithm to the assignment of mass spectrometric cross-linking data.

    Science.gov (United States)

    Petrotchenko, Evgeniy V; Borchers, Christoph H

    2014-09-01

    Cross-linking combined with MS involves enzymatic digestion of cross-linked proteins and identifying cross-linked peptides. Assignment of cross-linked peptide masses requires a search of all possible binary combinations of peptides from the cross-linked proteins' sequences, which becomes impractical with increasing complexity of the protein system and/or if digestion enzyme specificity is relaxed. Here, we describe the application of a fast sorting algorithm to search large sequence databases for cross-linked peptide assignments based on mass. This same algorithm has been used previously for assigning disulfide-bridged peptides (Choi et al., ), but has not previously been applied to cross-linking studies. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Characterization of Unruh channel in the context of open quantum systems

    International Nuclear Information System (INIS)

    Banerjee, Subhashish; Alok, Ashutosh Kumar; Omkar, S.; Srikanth, R.

    2017-01-01

    In this work, we study an important facet of field theories in curved spacetime, viz. the Unruh effect, by making use of ideas of statistical mechanics and quantum foundations. Aspects of decoherence and dissipation, natural artifacts of open quantum systems, along with foundational issues such as the trade-off between coherence and mixing as well as various aspects of quantum correlations are investigated in detail for the Unruh effect. We show how the Unruh effect can be quantified mathematically by the Choi matrix approach. We study how environmentally induced decoherence modifies the effect of the Unruh channel. The differing effects of a dissipative or non-dissipative environment are noted. Further, useful parameters characterizing channel performance such as gate and channel fidelity are applied here to the Unruh channel, both with and without external influences. Squeezing, which is known to play an important role in the context of particle creation, is shown to be a useful resource in a number of scenarios.

  9. Quantum Networks: General theory and applications

    International Nuclear Information System (INIS)

    Bisio, A.; D'Ariano, G. M.; Perinotti, P.; Chiribella, G.

    2011-01-01

    In this work we present a general mathematical framework to deal with Quantum Networks, i.e. networks resulting from the interconnection of elementary quantum circuits. The cornerstone of our approach is a generalization of the Choi isomorphism that allows one to efficiently represent any given Quantum Network in terms of a single positive operator. Our formalism allows one to face and solve many quantum information processing problems that would be hardly manageable otherwise, the most relevant of which are reviewed in this work: quantum process tomography, quantum cloning and learning of transformations, inversion of a unitary gate, information-disturbance tradeoff in estimating a unitary transformation, cloning and learning of a measurement device (Authors)

  10. Femtosecond laser ablation of silver foil with single and double pulses

    CSIR Research Space (South Africa)

    Roberts, DE

    2009-01-01

    Full Text Available . Tan, B.K.A. Ngoi, Opt. Laser Technol. 34 (2002) 199–202. [5] M. Hashida, A.F. Semerok, O. Gobert, G. Petite, Y. Izawa, J.F. Wagner, Appl. Surf. Sci. 197–198 (2002) 862–867. [6] P.T. Mannion, J. Magee, E. Coyne, G.M. O’Connor, Proc. SPIE 4876 (2003.... Nicolas, D. Anglos, Spectrochim. Acta B 63 (2008) 1006– 1010. [25] S. Singha, Z. Hu, R.J. Gordon, J. Appl. Phys. 104 (2008) 113520. [26] T.Y. Choi, D.J. Hwang, C.P. Girgoropoulos, Appl. Surf. Sci. (2002) 720–725. [27] A. Semerok, C. Dutouquet, Thin...

  11. Optimal control of quantum measurement

    Energy Technology Data Exchange (ETDEWEB)

    Egger, Daniel; Wilhelm, Frank [Theoretical Physics, Saarland University, 66123 Saarbruecken (Germany)

    2015-07-01

    Pulses to steer the time evolution of quantum systems can be designed with optimal control theory. In most cases it is the coherent processes that can be controlled and one optimizes the time evolution towards a target unitary process, sometimes also in the presence of non-controllable incoherent processes. Here we show how to extend the GRAPE algorithm in the case where the incoherent processes are controllable and the target time evolution is a non-unitary quantum channel. We perform a gradient search on a fidelity measure based on Choi matrices. We illustrate our algorithm by optimizing a measurement pulse for superconducting phase qubits. We show how this technique can lead to large measurement contrast close to 99%. We also show, within the validity of our model, that this algorithm can produce short 1.4 ns pulses with 98.2% contrast.

  12. Anti-resonance scattering at defect levels in the quantum conductance of a one-dimensional system

    Science.gov (United States)

    Sun, Z. Z.; Wang, Y. P.; Wang, X. R.

    2002-03-01

    For the ballistic quantum transport, the conductance of one channel is quantized to a value of 2e^2/h described by the Landauer formula. In the presence of defects, electrons will be scattered by these defects. Thus the conductance will deviate from the values of the quantized conductance. We show that an anti-resonance scattering can occur when an extra defect level is introduced into a conduction band. At the anti-resonance scattering, exact one quantum conductance is destroyed. The conductance takes a non-zero value when the Fermi energy is away from the anti-resonance scattering. The result is consistent with recent numerical calculations given by H. J. Choi et al. (Phys. Rev. Lett. 84, 2917(2000)) and P. L. McEuen et al. (Phys. Rev. Lett. 83, 5098(1999)).

  13. Exact closed-form solutions of a fully nonlinear asymptotic two-fluid model

    Science.gov (United States)

    Cheviakov, Alexei F.

    2018-05-01

    A fully nonlinear model of Choi and Camassa (1999) describing one-dimensional incompressible dynamics of two non-mixing fluids in a horizontal channel, under a shallow water approximation, is considered. An equivalence transformation is presented, leading to a special dimensionless form of the system, involving a single dimensionless constant physical parameter, as opposed to five parameters present in the original model. A first-order dimensionless ordinary differential equation describing traveling wave solutions is analyzed. Several multi-parameter families of physically meaningful exact closed-form solutions of the two-fluid model are derived, corresponding to periodic, solitary, and kink-type bidirectional traveling waves; specific examples are given, and properties of the exact solutions are analyzed.

  14. Static yield stress of a magnetorheological fluid containing Pickering emulsion polymerized Fe2O3/polystyrene composite particles.

    Science.gov (United States)

    Seo, Youngwook P; Kwak, Soonjong; Choi, Hyoung Jin; Seo, Yongsok

    2016-02-01

    The flow behaviors of magnetorheological (MR) suspensions containing Pickering emulsion polymerized Fe2O3/polystyrene (PS) composite particles were reanalyzed using the Seo-Seo model. The experimental shear stress data obtained experimentally from the magnetorheological fluid fit well to the Seo-Seo model, indicating that this model can describe the structural reformation process of the aligned fibers at various shear rates. Unlike the dynamic yield stress obtained from the Cho-Choi-Jhon (CCJ) model, the static yield stresses obtained from the Seo-Seo model exhibit the same quadratic dependence on the magnetic field strength for both pure Fe2O3 particle suspension and Fe2O3/PS particle suspensions, which is in agreement with the predictions of the polarization model. The static yield stress plausibly explains the difference in underlying mechanism of MR fluids. Copyright © 2015 Elsevier Inc. All rights reserved.

  15. Recent progress in the use of 'omics technologies in brassicaceous vegetables

    Directory of Open Access Journals (Sweden)

    Katja eWitzel

    2015-04-01

    Full Text Available Continuing advances in 'omics methodologies and instrumentation is enhancing the under-standing of how plants cope with the dynamic nature of their growing environment. 'Omics platforms have been only recently extended to cover horticultural crop species. Many of the most widely cultivated vegetable crops belong to the genus Brassica: these include plants grown for their root (turnip, rutabaga/swede, their swollen stem base (kohlrabi, their leaves (cabbage, kale, pak choi and their inflorescence (cauliflower, broccoli.Characterization at the genome, transcript, protein and metabolite levels has illustrated the complexity of the cellular response to a whole series of environmental stresses, including nutrient deficiency, pathogen attack, heavy metal toxicity, cold acclimation, and excessive and sub-optimal irradiation. This review covers recent applications of 'omics technologies to the brassicaceous vegetables, and discusses future scenarios in achieving improvements in crop end-use quality.

  16. Why not procrastinate? Development and validation of a new active procrastination scale.

    Science.gov (United States)

    Choi, Jin Nam; Moran, Sarah V

    2009-04-01

    Procrastination has been studied as a dysfunctional, self-effacing behavior that ultimately results in undesirable outcomes. However, A. H. C. Chu and J. N. Choi (2005) found a different form of procrastination (i.e., active procrastination) that leads to desirable outcomes. The construct of active procrastination has a high potential to expand the time management literature and is likely to be adopted by researchers in multiple areas of psychology. To facilitate the research on this new construct and its further integration into the literature, the authors developed and validated a new, expanded measure of active procrastination that reliably assesses its four dimensions. Using this new measure of active procrastination, they further examined its nomological network. The new 16-item measure is a critical step toward further empirical investigation of active procrastination.

  17. Time-frequency analysis of fusion plasma signals beyond the short-time Fourier transform paradigm: An overview

    International Nuclear Information System (INIS)

    Bizarro, Joao P.S.; Figueiredo, Antonio C.A.

    2008-01-01

    Performing a time-frequency (t-f) analysis on actual magnetic pick-up coil data from the JET tokamak, a comparison is presented between the spectrogram and the Wigner and Choi-Williams distributions. Whereas the former, which stems from the short-time Fourier transform and has been the work-horse for t-f signal processing, implies an unavoidable trade-off between time and frequency resolutions, the latter two belong to a later generation of distributions that yield better, if not optimal joint t-f localization. Topics addressed include signal representation in the t-f plane, frequency identification and evolution, instantaneous-frequency estimation, and amplitude tracking

  18. A Verification Study on the Loop-Breaking Logic of FTREX

    International Nuclear Information System (INIS)

    Choi, Jong Soo

    2008-01-01

    The logical loop problem in fault tree analysis (FTA) has been solved by manually or automatically breaking their circular logics. The breaking of logical loops is one of uncertainty sources in fault tree analyses. A practical method which can verify fault tree analysis results was developed by Choi. The method has the capability to handle logical loop problems. It has been implemented in a FORTRAN program which is called VETA (Verification and Evaluation of fault Tree Analysis results) code. FTREX, a well-known fault tree quantifier developed by KAERI, has an automatic loop-breaking logic. In order to make certain of the correctness of the loop-breaking logic of FTREX, some typical trees with complex loops are developed and applied to this study. This paper presents some verification results of the loop-breaking logic tested by the VETA code

  19. Conditions for uniqueness of product representations for separable quantum channels and separable quantum states

    International Nuclear Information System (INIS)

    Cohen, Scott M.

    2014-01-01

    We give a sufficient condition that an operator sum representation of a separable quantum channel in terms of product operators is the unique product representation for that channel, and then provide examples of such channels for any number of parties. This result has implications for efforts to determine whether or not a given separable channel can be exactly implemented by local operations and classical communication. By the Choi-Jamiolkowski isomorphism, it also translates to a condition for the uniqueness of product state ensembles representing a given quantum state. These ideas follow from considerations concerning whether or not a subspace spanned by a given set of product operators contains at least one additional product operator

  20. The effect of neutral-surface iron oxide nanoparticles on cellular uptake and signaling pathways

    Directory of Open Access Journals (Sweden)

    Kim E

    2016-09-01

    Full Text Available Eunjoo Kim,1 Joon Mee Kim,2 Lucia Kim,2 Suk Jin Choi,2 In Suh Park,2 Jee Young Han,2 Young Chae Chu,2 Eun Sook Choi,1 Kun Na,3 Soon-Sun Hong4 1Division of Nano and Energy Convergence Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST, Daegu, 2Department of Pathology, Inha University College of Medicine, Incheon, 3Department of Biotechnology, Catholic University of Korea, Bucheon, 4Department of Biomedical Sciences, Inha University College of Medicine, Incheon, South Korea Abstract: In recent years, iron oxide nanoparticles (IONPs have been applied widely to biomedical fields. However, the relationship between the physicochemical properties of IONPs and their biological behavior is not fully understood yet. We prepared 3-methacryloxypropyl­trimethoxysilane (MPS-coated IONPs, which have a neutral hydrophobic surface, and compared their biological behavior to that of Resovist (ferucarbotran, a commercialized IONP formulation modified with carboxymethyl dextran. The rate of MPS-IONP uptake by human aortic endothelial cells (HAoECs was higher than ferucarbotran uptake, indicating that the neutral hydrophobic nature of MPS-IONPs allowed them to be absorbed more readily through the plasma membrane. However, the signaling pathways activated by MPS-IONPs and ferucarbotran were comparable, suggesting that surface charge is not a key factor for inducing changes in HAoECs. In vivo fate analysis showed that MPS-IONPs accumulated for longer periods in tissues than hydrophilic ferucarbotran. These findings could enlarge our understanding of NP behavior for advanced applications in the biomedical field. Keywords: iron oxide nanoparticles, neutral hydrophobic surface, signaling pathway, uptake, accumulation, reactive oxygen species (ROS

  1. CAN THE MASSES OF ISOLATED PLANETARY-MASS GRAVITATIONAL LENSES BE MEASURED BY TERRESTRIAL PARALLAX?

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, M.; Botzler, C. S.; Bray, J. C.; Cherrie, J. M.; Rattenbury, N. J. [Department of Physics, University of Auckland, Private Bag 92019, Auckland 1142 (New Zealand); Philpott, L. C. [Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z4 (Canada); Abe, F.; Muraki, Y. [Solar-Terrestrial Environment Laboratory, Nagoya University, Nagoya 464-8601 (Japan); Albrow, M. D. [Department of Physics and Astronomy, University of Canterbury, P.O. Box 4800, Christchurch 8020 (New Zealand); Bennett, D. P. [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Bond, I. A. [Institute for Information and Mathematical Sciences, Massey University, Private Bag 102-904, Auckland 1330 (New Zealand); Christie, G. W.; Natusch, T. [Auckland Observatory, PO Box 180, Royal Oak, Auckland 1345 (New Zealand); Dionnet, Z. [Université d' Orsay, bat 470, F-91400 Orsay (France); Gould, A. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Han, C. [Department of Physics, Chungbuk National University, 410 Seongbong-Rho, Hungduk-Gu, Chongju 371-763 (Korea, Republic of); Heyrovský, D. [Institute of Theoretical Physics, Charles University in Prague, Faculty of Mathematics and Physics, V Holesovickach 2, 18000 Prague (Czech Republic); McCormick, J. M. [Farm Cove Observatory, 2/24 Rapallo Place, Pakuranga, Auckland 2012 (New Zealand); Moorhouse, D. M. [Kumeu Observatory, Kumeu (New Zealand); Skowron, J., E-mail: mfre070@aucklanduni.ac.nz [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478, Warszawa (Poland); and others

    2015-02-01

    Recently Sumi et al. reported evidence for a large population of planetary-mass objects (PMOs) that are either unbound or orbit host stars in orbits ≥10 AU. Their result was deduced from the statistical distribution of durations of gravitational microlensing events observed by the MOA collaboration during 2006 and 2007. Here we study the feasibility of measuring the mass of an individual PMO through microlensing by examining a particular event, MOA-2011-BLG-274. This event was unusual as the duration was short, the magnification high, the source-size effect large, and the angular Einstein radius small. Also, it was intensively monitored from widely separated locations under clear skies at low air masses. Choi et al. concluded that the lens of the event may have been a PMO but they did not attempt a measurement of its mass. We report here a re-analysis of the event using re-reduced data. We confirm the results of Choi et al. and attempt a measurement of the mass and distance of the lens using the terrestrial parallax effect. Evidence for terrestrial parallax is found at a 3σ level of confidence. The best fit to the data yields the mass and distance of the lens as 0.80 ± 0.30 M {sub J} and 0.80 ± 0.25 kpc respectively. We exclude a host star to the lens out to a separation ∼40 AU. Drawing on our analysis of MOA-2011-BLG-274 we propose observational strategies for future microlensing surveys to yield sharper results on PMOs including those down to super-Earth mass.

  2. Organic soil production from urban soil, spent mushroom substrate, and other additives

    Science.gov (United States)

    Pham, Nhung Thi Ha

    2017-09-01

    In recent years, spent mushroom substrate (SMS) is becoming the huge problem in environmental pollution issues from mushroom production. However, SMS is also a nutrient-rich ogranic material with available nutrients and high porosity. Therefore, the value of products made from SMS should be exploited to take full advantage of agricultural by-product, support organic agriculture development without environmental pollution. The research has built 5 experimental formulas (4 mixed formulas and 1 control formulas with only urban soil). The analysis results of soil samples from mixed formulas and the control formula witness a significant increase in moisture and OM of mixed formulas (moisture from 36-42%, OM from 5.5-6.9%) after 20 treatment days, and N-P-K contents are also improved remarkably. 60 days later, soil nutrients in mixed formulas continue to rise, with highest OM (8.679%) at CT1; N (0.154%) at CT4; K2O (0,698%) and P2O5 (0,172%) at CT3, in addition, heavy metal contents in all formulas are under standard limit. Synthetic assessment of all norms indicates that the best organic soil product comes from CT3. The pak choi planting experiments are performed show that the growth of plants cultivated on organic soil products made from mixed formulas are much better than plants are grown on initially soil, and they also have no pestilent insect. Specially, pak choi planted on organic soil from CT3 have sharp developing with excellent tolerance ability, quantity and area of leaves are high. Thus, CT3 is the most suitable formula to increase soil nutrients, to solve spent mushroom subtrate streament problems after harvest, and for sustainable agricultural development.

  3. Long-Term Survival According to Histology and Radiologic Response to Preoperative Chemotherapy in 126 Patients Undergoing Resection of Non-GIST Sarcoma Liver Metastases.

    Science.gov (United States)

    Goumard, Claire; Marcal, Leonardo P; Wang, Wei-Lien; Somaiah, Neeta; Okuno, Masayuki; Roland, Christina L; Tzeng, Ching-Wei D; Chun, Yun Shin; Feig, Barry W; Vauthey, Jean-Nicolas; Conrad, Claudius

    2018-01-01

    Non-gastrointestinal stromal tumor sarcomas (NGSs) have heterogeneous histology, and this heterogeneity may lead to uncertainty regarding the prognosis of patients with liver metastases from NGS (NGSLM) and decision regarding their surgical management. Furthermore, the role of preoperative chemotherapy in treatment of NGSLM remains poorly defined. We investigated long-term survival and its correlation to response to preoperative chemotherapy in patients with NGSLM. Patients who underwent liver resection for NGSLM during 1998-2015 were identified. Clinical, histopathologic, and survival data were analyzed. Multivariate analysis was performed using a Cox proportional hazards model. 126 patients [62 (49%) with leiomyosarcoma] were included. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were 49.3 and 14.9%, respectively. Survival did not differ by histologic subtype, primary tumor location, or use of preoperative or postoperative chemotherapy. NGSLM ≥ 10 cm and extrahepatic metastases at NGSLM diagnosis were the only independent risk factors for OS. In the 83 (66%) patients with metachronous NSGLM, disease-free interval > 6 months was associated with improved OS and RFS. Among the 65 patients (52%) who received preoperative chemotherapy, radiologic response according to Choi criteria specifically was associated with improved OS (p = 0.04), but radiologic response according to RECIST 1.1 criteria was not. Resection of NGSLM led to a 5-year OS rate of 49%, independent of histologic subtype and primary tumor location. Choi criteria (which take into account tumor density) are superior to RECIST 1.1 in assessing radiologic response and should be used to assess response to preoperative chemotherapy.

  4. NEW INCOMING ACCESSIONS OF BRASSICA RAPA L. INTO THE VIR PLANT COLLECTION

    Directory of Open Access Journals (Sweden)

    A. M. Artemieva

    2017-01-01

    Full Text Available The crops of Brassica rapa L. species are varieties such as pak-choi, tatsoi, wutacai, tsoisum, mizuna, mibuna, brokkoletto and Japanese leafy turnips Komatsuna, Kurona, Hiroshimana, Shirona, Mana, which are all characterized by  early-ripening,  high  productivity,  presence of valuable biochemical compounds and relatively simple growing requirements. The nappa cabbage is widespread and cultivated everywhere in the world as open field and greenhouse crop. Other varieties are grown locally, namely brokkoletto is grown in Italy, whereas other mentioned varieties are mostly cultivated in the Southeast Asian countries, where population uses them for different processing technologies. There is the nappa cabbage that is mostly cultivated, particularly for industrial production  in Russia. The Chinese cabbage (pak choi, Japanese cabbage, Japanese mustard  spinach  or  Komatsuna  are  not  very widespread and practically unknown crop. However, vegetable growers are interested in using new cole crops, and gardeners know about values of related varieties of nappa cabbage in the group of Asian cole crops. The analysis of incoming genetic accessions of Brassica rapa L. crops that have been included into the VIR plant collection is given. All  botanical  subspecies  and  varieties of  leafy varieties have been taken for the study. The detailed description of new for Russia varieties, such as purple, brokkoletto, rosette pakchoi as well as well as types of cultivars that haven’t still included into State Register of Breeding Achievements of Russian Federation are given. According to  research results obtained at Pushkin VIR laboratories (Saint-Petersburg the  initial  breeding  accessions  have been selected to  be  sources of  such characteristics as productivity,  early-ripening, disease resistance and valuable biochemical compounds.

  5. Multi-color phase imaging and sickle cell anemia (Conference Presentation)

    Science.gov (United States)

    Hosseini, Poorya; Zhou, Renjie; Yaqoob, Zahid; So, Peter T. C.

    2016-03-01

    Quantitative phase measurements at multiple wavelengths has created an opportunity for exploring new avenues in phase microscopy such as enhancing imaging-depth (1), measuring hemoglobin concentrations in erythrocytes (2), and more recently in tomographic mapping of the refractive index of live cells (3). To this end, quantitative phase imaging has been demonstrated both at few selected spectral points as well as with high spectral resolution (4,5). However, most of these developed techniques compromise imaging speed, field of view, or the spectral resolution to perform interferometric measurements at multiple colors. In the specific application of quantitative phase in studying blood diseases and red blood cells, current techniques lack the required sensitivity to quantify biological properties of interest at individual cell level. Recently, we have set out to develop a stable quantitative interferometric microscope allowing for measurements of such properties for red cells without compromising field of view or speed of the measurements. The feasibility of the approach will be initially demonstrated in measuring dispersion curves of known solutions, followed by measuring biological properties of red cells in sickle cell anemia. References: 1. Mann CJ, Bingham PR, Paquit VC, Tobin KW. Quantitative phase imaging by three-wavelength digital holography. Opt Express. 2008;16(13):9753-64. 2. Park Y, Yamauchi T, Choi W, Dasari R, Feld MS. Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells. Opt Lett. 2009;34(23):3668-70. 3. Hosseini P, Sung Y, Choi Y, Lue N, Yaqoob Z, So P. Scanning color optical tomography (SCOT). Opt Express. 2015;23(15):19752-62. 4. Jung J-H, Jang J, Park Y. Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging. Anal Chem. 2013;85(21):10519-25. 5. Rinehart M, Zhu Y, Wax A. Quantitative phase spectroscopy. Biomed Opt Express. 2012;3(5):958-65.

  6. Semiactive balancing control scheme in a rotor - bearing system supported on Mr. Dampers: design and experiments

    Energy Technology Data Exchange (ETDEWEB)

    Silva Navarro, Gerardo; Cabrera Amado, Alvaro [Cinvestav, IPN, Mexico, D.F. (Mexico)

    2007-11-15

    This paper deals with the problem of semiactive balancing control of a rotor-bearing system, where one journal bearings is supported on two radial Magneto-Rheological (MR) dampers. The mathematical model of the rotor-bearing system results from an orthotropic Jeffcott-like model and the dynamics associated to the MR dampers, whose rheological properties depend on the current inputs. For control purposes we use the Choi-Lee-Park polynomial for the MR dampers, which is quite consistent with the tpical nonlinear and complex hysteresis behavior and also simplifies the physical implementation on an experimental setup. The semiactive control scheme for the unbalance reponse of the rotor-bearing system is synthesized using sliding-mode control techniques. Some numerical and experimental results are included to illustrate the dynamic performance and robustness of the overall system. [Spanish] En este trabajo se abora el problema de control semiactivo del desbalance en un sistema rotor-chumacera, donde una de las chumaceras convencionales se monta sobre una suspension con dos amortiguadores Magneto-Reologicos (MR) radiales. El modelo matematico del sistema rotorchumacera se obtiene de un modelo tipo Jefcott ortotropico y la dinamica de los amortiguadores MR, cuyas propiedades reologicas dependen de las corrientes electricas de alimentacion. Para propositos de control se emplea el modelo polinomial de Choi-Lee-Park para los dos amortiguadores MR, el cual es consistente con el tipico comportamiento no-lineal y de histeresis, permitiendo simplificar su implementacion fisica en una plataforma experimental. El esquema de control semiactivo de la respuesta al desbalance, en el sistema rotor-chumacera, se basa en las tecnicas de control por modos deslizantes. Se presentan algunos resultados de simulacion numerica y experimentos que utilizan el funcionamiento y robustez del sistema completo.

  7. Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study

    Directory of Open Access Journals (Sweden)

    Arokiyaraj S

    2014-01-01

    Full Text Available Selvaraj Arokiyaraj,1 Mariadhas Valan Arasu,2 Savariar Vincent,3 Nyayirukannaian Udaya Prakash,4 Seong Ho Choi,5 Young-Kyoon Oh,1 Ki Choon Choi,2 Kyoung Hoon Kim1,61Department of Animal Nutrition and Physiology, National Institute of Animal Science, Rural Development Administration, Suwon, Republic of Korea; 2Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Seonghwan-Eup, Cheonan-Si, Chungnam, Republic of Korea; 3Center for Environmental Research and Development, Loyola College, Chennai, India; 4Research and Development, Vel Tech Dr RR and Dr SR Technical University, Chennai, India; 5Department of Animal Science, Chungbuk National University, Chungbuk, Republic of Korea; 6Department of Animal Science, Seoul National University, Pyeongchang, Republic of KoreaAbstract: The present work reports a simple, cost-effective, and ecofriendly method for the synthesis of silver nanoparticles (AgNPs using Chrysanthemum indicum and its antibacterial and cytotoxic effects. The formation of AgNPs was confirmed by color change, and it was further characterized by ultraviolet–visible spectroscopy (435 nm. The phytochemical screening of C. indicum revealed the presence of flavonoids, terpenoids, and glycosides, suggesting that these compounds act as reducing and stabilizing agents. The crystalline nature of the synthesized particles was confirmed by X-ray diffraction, as they exhibited face-centered cubic symmetry. The size and morphology of the particles were characterized by transmission electron microscopy, which showed spherical shapes and sizes that ranged between 37.71–71.99 nm. Energy-dispersive X-ray spectroscopy documented the presence of silver. The antimicrobial effect of the synthesized AgNPs revealed a significant effect against the bacteria Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. Additionally, cytotoxic assays showed no toxicity of AgNPs toward 3T3 mouse embryo

  8. Genomic inferences of domestication events are corroborated by written records in Brassica rapa.

    Science.gov (United States)

    Qi, Xinshuai; An, Hong; Ragsdale, Aaron P; Hall, Tara E; Gutenkunst, Ryan N; Chris Pires, J; Barker, Michael S

    2017-07-01

    Demographic modelling is often used with population genomic data to infer the relationships and ages among populations. However, relatively few analyses are able to validate these inferences with independent data. Here, we leverage written records that describe distinct Brassica rapa crops to corroborate demographic models of domestication. Brassica rapa crops are renowned for their outstanding morphological diversity, but the relationships and order of domestication remain unclear. We generated genomewide SNPs from 126 accessions collected globally using high-throughput transcriptome data. Analyses of more than 31,000 SNPs across the B. rapa genome revealed evidence for five distinct genetic groups and supported a European-Central Asian origin of B. rapa crops. Our results supported the traditionally recognized South Asian and East Asian B. rapa groups with evidence that pak choi, Chinese cabbage and yellow sarson are likely monophyletic groups. In contrast, the oil-type B. rapa subsp. oleifera and brown sarson were polyphyletic. We also found no evidence to support the contention that rapini is the wild type or the earliest domesticated subspecies of B. rapa. Demographic analyses suggested that B. rapa was introduced to Asia 2,400-4,100 years ago, and that Chinese cabbage originated 1,200-2,100 years ago via admixture of pak choi and European-Central Asian B. rapa. We also inferred significantly different levels of founder effect among the B. rapa subspecies. Written records from antiquity that document these crops are consistent with these inferences. The concordance between our age estimates of domestication events with historical records provides unique support for our demographic inferences. © 2017 John Wiley & Sons Ltd.

  9. The Divisia real energy intensity indices: Evolution and attribution of percent changes in 20 European countries from 1995 to 2010

    International Nuclear Information System (INIS)

    Fernández González, P.; Landajo, M.; Presno, M.J.

    2013-01-01

    This paper analyzes the evolution of real energy efficiency in the European Union and the attribution across countries of its percent change. Relying on a multiplicative energy intensity approach that is implemented through the Sato-Vartia Logarithmic Mean Divisia Index method, we decompose the change in aggregate energy intensity in 20 European countries for the period from 1995 to 2010. A comparative analysis of real energy intensity indices is also carried out. In addition, a new tool to monitor changes in real energy intensity in greater detail is applied. The attribution analysis of IDA (Index Decomposition Analysis) as proposed by Choi and Ang (Choi KH, Ang BW. Attribution of changes in Divisia real energy intensity index – an extension to index decomposition analysis. Energy Economics 2012;34:171–6) is used in order to assess the contribution of each individual sector to the percent change in real energy intensity. Results indicate that the European countries, particularly the former communist ones, made a remarkable effort to improve energy efficiency. Our analysis also suggests some strategies –including promotion and adaptation to more efficient techniques, innovation, improved use of technologies, R and D, and substitution for higher quality energies-, which are of particular interest to the industry sector -including construction- in ex-communist EU members, and to the industry and transport plus hotels and restaurants sectors in Western countries. - Highlights: • We apply a single and multi-period attribution analysis approach [1]. • Technical change, improved use of tech and quality energies, keys to AEI drop. • Real energy intensity shows valuable progress in former communist European members. • The biggest attribution of percent change in real energy intensity was to Industry. • Western EU: Services and Agriculture poor contributors to real energy intensity drop

  10. Perspectives for research of the procrastination phenomenon in professional work

    Directory of Open Access Journals (Sweden)

    Valentina V. Barabanshchikova

    2015-12-01

    Full Text Available The paper describes the current state of the procrastination phenomenon in professional work, reviews the basic unexplored aspects in this area, and highlights the promising areas of scientific analysis. The survey of the existing literature periodization shows that the quantity of researches devoted to procrastination is growing exponentially every year. In spite of a pronounced research interest in this construct, in native and foreign psychological science procrastination phenomenon in the professional work is represented insufficiently. Firstly, there is no common and generally accepted definition of procrastination (Corkin, Yu, Lindt, 2011; Steel, 2010; Krause, Freund, 2014, that suggests that there is a deep terminological crisis in this area. Secondly, the characteristic of delaying the implementation of the elements of workload is represented only by the example of a fairly narrow range of professional activities, which makes it relevant to study the specificity of the differentiated functioning of the phenomenon on the material of a wide range of professions. Thirdly, in psychology there are no information about the peculiarities of the so-called “active” procrastination manifestations in professional activity, which is the tendency of conscious assignments delaying to achieve the optimum final result (Chu, Choi, 2005; Choi, Moran, 2009. Fourthly, there is an acute shortage of standardized psychodiagnostic tools to evaluate this phenomenon in work (most of the existing methods have been tested on samples of students and are aimed at identifying academic procrastination. In the fifth place, there are no science-based allocation of methods of coping with destructive manifestations of the psychological strategy of the job functions postponement in a professional work.

  11. Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain

    Directory of Open Access Journals (Sweden)

    Bellessort B

    2018-04-01

    Full Text Available Brice Bellessort,1 Anne Bachelot,1,2 Virginie Grouthier,2 Camille De Lombares,1 Nicolas Narboux-Neme,1 Paolo Garagnani,3,4 Chiara Pirazzini,3,4 Simonetta Astigiano,5 Luca Mastracci,6,7 Anastasia Fontaine,1 Gladys Alfama,1 Evelyne Duvernois-Berthet,1 Giovanni Levi1 1Evolution of Endocrine Regulations, Department AVIV, National Museum of Natural History, Paris, France; 2AP-HP, Department of Endocrinology and Reproductive Medicine, Reference Center for Rare Endocrine Diseases, Pitié-Salpêtrière Hospital, UPMC, Paris, France; 3Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 4Interdepartmental Center “L. Galvani”, University of Bologna, Bologna, Italy; 5Department of Integrated Oncological Therapies, San Martino Hospital, Genova, Italy; 6Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genoa, Genova, Italy; 7Division of Anatomic Pathology, Department of Surgical Science and Integrated Diagnostics, University of Genoa, Genova, Italy Background: It has been repetitively shown that the transcription factors DLX5 and DLX6 are drastically downregulated in endometriotic lesions when compared with eutopic endometrium. These findings suggest that regulatory cascades involving DLX5/6 might be at the origin of endometriosis symptoms such as chronic pelvic pain (CPP. We have shown that inactivation of Dlx5 and Dlx5/6 in the mouse uterus results in an endometrial phenotype reminiscent of endometriosis. Methods: We focused on genes that present a similar deregulation in endometriosis and in Dlx5/6-null mice in search of new endometriosis targets. Results: We confirmed a strong reduction of DLX5 expression in endometriosis implants. We identified a signature of 30 genes similarly deregulated in human endometriosis implants and in Dlx5/6-null mouse uteri, reinforcing the notion that the downregulation of Dlx5/6 is an early event in

  12. Co-authorship patterns and networks of Korean radiation oncologists

    International Nuclear Information System (INIS)

    Choi, Jin Hyun; Kang, Jin Oh; Park, Seo Hyun; Kim, Sang Ki

    2011-01-01

    and Oncology and others (p = 0.000), respectively. Among the analysis, a significant difference in the average number of author per article was indicated. The out-degree centrality of network among authors was 4.26% (2.03-7.09%) while in-degree centrality was 1.31% (0.53-2.84%). The three significant nodes were classified and listed as following: Choi, Eun Kyung for 1991-1995, Kim, Dae Young for 1998-2001, Park, Won and Lee, Sang Wook for 2003-2010. Choi, Eun Kyung and Kim, Dae Young appeared in two cases, and ranked as the highest degree in centrality. In the key player analysis, Choi, Eun Kyung and Lee, Sang Wook appeared in two cases, and ranked as the highest. From the cluster analysis, Sungkyunkwan University, Seoul National University and Yonsei University revealed as the three large clusters when Ulsan University, Chonnam National University, and Korea Institute of Radiological and Medical Science as the medium clusters. The Korean radiation oncologist's society shows a closed network with numerous relationships among the particular clusters, and the result indicates it is different from other institutions in the pattern of co-authorship formation of the major hospitals.

  13. Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

    Directory of Open Access Journals (Sweden)

    Kim SR

    2016-11-01

    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Sang Hyun Kim,1 Ha Ra Cho,2 Han Sol Kim,2 Yong Seok Choi,2 Young Wook Choi,1 Myung Joo Kang2 1Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea Abstract: Piroxicam (PRX, a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA in the synovial cavity. PRX-loaded NPs consisting of poly(lactic-co-glycolic acid, Eudragit RL, and polyvinyl alcohol were constructed with the following characteristics: particle size of 220 nm, zeta potential of 11.5 mV in phosphate-buffered saline, and loading amount of 4.0% (w/w of PRX. In optical and hyperspectral observations, the cationic NPs formed more than 50 µm-sized aggregates with HA, which was larger than the intercellular gaps between synoviocytes. In an in vivo pharmacokinetic study in rats, area under the plasma concentration–time curve (AUC0–24 h and maximum plasma concentration (Cmax of PRX after IA injection of the cationic NPs were <70% (P<0.05 and 60% (P<0.05, respectively, compared to those obtained from drug solution. Moreover, the drug concentration in joint tissue 24 h after dosing with the cationic NPs was 3.2-fold (P<0.05 and 1.8-fold (P<0.05 higher than that from drug solution and neutrally charged NPs, respectively. Therefore, we recommend the IA cationic NP therapy as an effective alternative to traditional oral therapy with PRX, as it increases drug retention selectively in the joint. Keywords: piroxicam

  14. Receptor-targeted, drug-loaded, functionalized graphene oxides for chemotherapy and photothermal therapy

    Directory of Open Access Journals (Sweden)

    Thapa RK

    2016-06-01

    Full Text Available Raj Kumar Thapa,1 Ju Yeon Choi,1 Bijay Kumar Poudel,1 Han-Gon Choi,2 Chul Soon Yong,1 Jong Oh Kim1 1College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongsanbuk-do, South Korea; 2College of Pharmacy, Hanyang University, Ansan, South Korea Abstract: Cancer is one of the leading causes of death worldwide. Although different chemotherapeutic agents have been developed to treat cancers, their use can be limited by low cellular uptake, drug resistance, and side effects. Hence, targeted drug delivery systems are continually being developed in order to improve the efficacy of chemotherapeutic agents. The main aim of this study was to prepare folic acid (FA-conjugated polyvinyl pyrrolidone-functionalized graphene oxides (GO (FA-GO for targeted delivery of sorafenib (SF. GO were prepared using a modified Hummer’s method and subsequently altered to prepare FA-GO and SF-loaded FA-GO (FA-GO/SF. Characterization of GO derivatives was done using ultraviolet/visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, atomic force microscopy, zeta potential measurements, and determination of in vitro drug release. Hemolytic toxicity, in vitro cytotoxicity, cellular uptake, and apoptotic effects of FA-GO/SF were also investigated. The results revealed that GO was successfully synthesized and that further transformation to FA-GO improved the stability and SF drug-loading capacity. In addition, the enhanced SF release under acidic conditions suggested possible benefits for cancer treatment. Conjugation of FA within the FA-GO/SF delivery system enabled targeted delivery of SF to cancer cells expressing high levels of FA receptors, thus increasing the cellular uptake and apoptotic effects of SF. Furthermore, the photothermal effect achieved by exposure of GO to near-infrared irradiation enhanced the anticancer effects of FA-GO/SF. Taken together, FA-GO/SF is a potential carrier for targeted delivery of chemotherapeutic agents in cancer

  15. Effects of a natural sepiolite bearing material and lime on the immobilization and persistence of cadmium in a contaminated acid agricultural soil.

    Science.gov (United States)

    Cao, Xueying; Hu, Pengjie; Tan, Changyin; Wu, Longhua; Peng, Bo; Christie, Peter; Luo, Yongming

    2018-05-25

    Soil contamination with cadmium (Cd) represents a substantial threat to human health and environmental quality. Long-term effectiveness and persistence of remediation are two important criteria for the evaluation of amendment techniques used to remediate soils polluted with potentially toxic metals. In the current study, we investigated the remediation persistence of a natural sepiolite bearing material (NSBM, containing 15% sepiolite) and ground limestone (equivalent to > 98.0% CaO) on soil pH, Cd bioavailability, and Cd accumulation by pak choi (Brassica chinensis L.) during the growth of four consecutive crops in a Cd-contaminated acid soil with different amounts of NSBM (0, 0.2, 0.5, 1, 2, and 5%). Soil pH levels ranged from 5.21 to 7.76 during the first crop, 4.30 to 7.34 during the second, 4.23 to 7.80 during the third, and 4.33 to 6.98 during the fourth, and increased significantly with increasing the application rate of NSBM. Soil CaCl 2 -Cd and shoot Cd concentrations decreased by 8.11 to 99.2% and 6.58 to 94.5%, respectively, compared with the control throughout the four cropping seasons. A significant negative correlation was found between soil CaCl 2 -Cd and soil pH. Combined use of 0.1% lime and NSBM showed greater effects than NSBM alone, especially, when the application rate of NSBM was ˂ 2%. Moreover, pak choi tissue Cd concentrations in the treatments with NSBM addition alone at ≥ 2% or at ≥ 1% NSBM combined with 0.1% lime met the maximum permissible concentration (MPC) over the four crops, allowed by the Chinese and European regulations. Based on the present study, safe crop production in the test soil is possible at a soil pH > 6.38 and CaCl 2 -Cd soil Cd immobilization by NSBM without or with lime is a potentially feasible method of controlling the transfer of soil Cd into the food chain.

  16. Biomimetics: forecasting the future of science, engineering, and medicine

    Directory of Open Access Journals (Sweden)

    Hwang J

    2015-09-01

    Full Text Available Jangsun Hwang,1 Yoon Jeong,1,2 Jeong Min Park,3 Kwan Hong Lee,1,2,4 Jong Wook Hong,1,2 Jonghoon Choi1,2 1Department of Bionano Technology, Graduate School, Hanyang University, Seoul, 2Department of Bionano Engineering, Hanyang University ERICA, Ansan, Korea; 3Department of Biomedical Engineering, Boston University, 4OpenView Venture Partners, Boston, MA, USA Abstract: Biomimetics is the study of nature and natural phenomena to understand the principles of underlying mechanisms, to obtain ideas from nature, and to apply concepts that may benefit science, engineering, and medicine. Examples of biomimetic studies include fluid-drag reduction swimsuits inspired by the structure of shark’s skin, velcro fasteners modeled on burrs, shape of airplanes developed from the look of birds, and stable building structures copied from the backbone of turban shells. In this article, we focus on the current research topics in biomimetics and discuss the potential of biomimetics in science, engineering, and medicine. Our report proposes to become a blueprint for accomplishments that can stem from biomimetics in the next 5 years as well as providing insight into their unseen limitations. Keywords: biomimicry, tissue engineering, biomaterials, nature, nanotechnology, nanomedicine

  17. Developing brief fatigue short forms calibrated to a common mathematical metric: is content-balancing important?

    Directory of Open Access Journals (Sweden)

    Karon F Cook

    2010-08-01

    Full Text Available Karon F Cook1, Seung W Choi2, Kurt L Johnson1, Dagmar Amtmann11Department of Rehabilitation Medicine, University of Washington, Seattle, WA; 2Northwestern University Feinberg School of Medicine, Chicago, IL, USAAbstract: There are clinical and research settings in which concerns about respondent burden make the use of longer self-report measures impractical. Though computer adaptive testing provides an efficient strategy for measuring patient reported outcomes, the requirement of a computer interface makes it impractical for some settings. This study evaluated how well brief short forms, constructed from a longer measure of patient reported fatigue, reproduced scores on the full measure. When the items of an item bank are calibrated using an item response theory model, it is assumed that the items are fungible units. Theoretically, there should be no advantage to balancing the content coverage of the items. We compared short forms developed using a random item selection process to short forms developed with consideration of the items relation to subdomains of fatigue (ie, physical and cognitive fatigue. Scores on short forms developed using content balancing more successfully predicted full item bank scores than did scores on short forms developed by random selection of items.Keywords: psychometrics, outcomes, quality of life, measurement, fatigue

  18. Well-posedness of the Cauchy problem for models of large amplitude internal waves

    International Nuclear Information System (INIS)

    Guyenne, Philippe; Lannes, David; Saut, Jean-Claude

    2010-01-01

    We consider in this paper the 'shallow-water/shallow-water' asymptotic model obtained in Choi and Camassa (1999 J. Fluid Mech. 396 1–36), Craig et al (2005 Commun. Pure. Appl. Math. 58 1587–641) (one-dimensional interface) and Bona et al (2008 J. Math. Pures Appl. 89 538–66) (two-dimensional interface) from the two-layer system with rigid lid, for the description of large amplitude internal waves at the interface of two layers of immiscible fluids of different densities. For one-dimensional interfaces, this system is of hyperbolic type and its local well-posedness does not raise serious difficulties, although other issues (blow-up, loss of hyperbolicity, etc) turn out to be delicate. For two-dimensional interfaces, the system is nonlocal. Nevertheless, we prove that it conserves some properties of 'hyperbolic type' and show that the associated Cauchy problem is locally well posed in suitable Sobolev classes provided some natural restrictions are imposed on the data. These results are illustrated by numerical simulations with emphasis on the formation of shock waves

  19. Development of a chitosan based double layer-coated tablet as a platform for colon-specific drug delivery

    Directory of Open Access Journals (Sweden)

    Kim MS

    2016-12-01

    Full Text Available Min Soo Kim,1,* Dong Woo Yeom,1,* Sung Rae Kim,1 Ho Yub Yoon,1 Chang Hyun Kim,1 Ho Yong Son,1 Jin Han Kim,1 Sangkil Lee,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Keimyung University, Daegu, South Korea *These authors contributed equally to this work Abstract: A double layer-coated colon-specific drug delivery system (DL-CDDS was developed, which consisted of chitosan (CTN based polymeric subcoating of the core tablet containing citric acid for microclimate acidification, followed by an enteric coating. The polymeric composition ratio of Eudragit E100 and ethyl cellulose and amount of subcoating were optimized using a two-level factorial design method. Drug-release characteristics in terms of dissolution efficiency and controlled-release duration were evaluated in various dissolution media, such as simulated colonic fluid in the presence or absence of CTNase. Microflora activation and a stepwise mechanism for drug release were postulated. Consequently, the optimized DL-CDDS showed drug release in a controlled manner by inhibiting drug release in the stomach and intestine, but releasing the drug gradually in the colon (approximately 40% at 10 hours and 92% at 24 hours in CTNase-supplemented simulated colonic fluid, indicating its feasibility as a novel platform for CDD. Keywords: chitosan, colon-specific delivery, acidification, microflora, factorial design, controlled release

  20. The ATLAS Event Index: The Architecture of the Core Engine

    CERN Document Server

    Barberis, Dario; The ATLAS collaboration; Hrivnac, Julius

    2017-01-01

    The global view of the ATLAS Event Index system has been presented in the last ACAT. This talk will concentrate on the architecture of the system core component. This component handles the final stage of the event metadata import, it organizes its storage and provides a fast and feature-rich access to all information. A user is able to interrogate metadata in various ways, including by executing user-provided code on the data to make selections and to interpret the results. A wide spectrum of clients is available, from a set of linux-like commands to an interactive graphical Web Service. The stored event metadata contain the basic description of the related events, the references to the experiment event storage, the full trigger record and can be extended with other event characteristics. Derived collections of events can be created. Such collections can be annotated and tagged with further information. This talk will describe all system sub-components and their development evolution, which lead into the choi...

  1. True-and-error models violate independence and yet they are testable

    Directory of Open Access Journals (Sweden)

    Michael H. Birnbaum

    2013-11-01

    Full Text Available Birnbaum (2011 criticized tests of transitivity that are based entirely on binary choice proportions. When assumptions of independence and stationarity (iid of choice responses are violated, choice proportions could lead to wrong conclusions. Birnbaum (2012a proposed two statistics (correlation and variance of preference reversals to test iid, using random permutations to simulate p-values. Cha, Choi, Guo, Regenwetter, and Zwilling (2013 defended methods based on marginal proportions but conceded that such methods wrongly diagnose hypothetical examples of Birnbaum (2012a. However, they also claimed that ``true and error'' models also satisfy independence and also fail in such cases unless they become untestable. This article presents correct true-and-error models; it shows how these models violate iid, how they might correctly identify cases that would be misdiagnosed by marginal proportions, and how they can be tested and rejected. This note also refutes other arguments of Cha et al. (2013, including contentions that other tests failed to violate iid ``with flying colors'', that violations of iid ``do not replicate'', that type I errors are not appropriately estimated by the permutation method, and that independence assumptions are not critical to interpretation of marginal choice proportions.

  2. Sudden unilateral visual loss after autologous fat injection into the nasolabial fold

    Directory of Open Access Journals (Sweden)

    Sang Hyouk Park

    2008-10-01

    Full Text Available Sang Hyouk Park, Hae Jung Sun, Kyung Seek ChoiDepartment of ophthalmology, Soonchunhyang University College of Medicine, Seoul, KoreaAbstract: A 27-year-old female presented with sudden visual loss of her right eye after receiving an autologous fat injection into the right nasolabial fold. Fundus examination of the right eye showed multiple whitish patchy lesions with macular edema. Fluorescein angiogram showed deterioration of choroidal circulation with patchy choroidal filling and arm-to-retina circulation time and retinal arteriovenous passage time were delayed to 30 seconds and 20 seconds, respectively. There was no response in flash visual evoked potential (VEP. High dose steroid therapy (methylprednisolone 1 g/day/i.v. was done and about 2 weeks later, the disc edema subsided and retinal arteriovenous passage time of fluorescein angiogram was normalized but there was no improvement in visual acuity. Absence of a cherry red spot, deterioration of choroidal circulation with patchy choroidal fillings seen in fluorescein angiogram, and no response in flash VEP suggests multiple choroidal infarction due to perfusion defect of the short posterior ciliary artery. The autologous fat injected is thought to have entered the dorsal nasal artery and the retrograde migration of the emboli to the ophthalmic artery might have caused the multiple occlusions of the short posterior ciliary artery.Keywords: autologous fat injection, ciliary artery occlusion, ischemic optic neuropathy

  3. Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

    Directory of Open Access Journals (Sweden)

    Lee YK

    2014-12-01

    Full Text Available Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: Although the cytotoxicity of nanoparticles (NPs is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses. Keywords: nanostructured biomaterials, blood response, cytotoxicity, immunotoxicity, protein corona

  4. Development of a colonoscopy add-on device for improvement of the intubation process

    Directory of Open Access Journals (Sweden)

    Litten JD

    2011-12-01

    Full Text Available Jonathan D Litten1, JungHun Choi2, David Drozek31Department of Mechanical Engineering; 2Department of Mechanical Engineering and Biomedical Engineering Program; 3College of Osteopathic Medicine, Department of Specialty Medicine, Ohio University, Athens, OH, USAAbstract: A colonoscopy add-on device has been developed to reduce intubation time without modification of the current colonoscope and peripheral devices. One of the main purposes of the system is to minimize trauma caused by the distal tip of the colonoscope. The detachable sensory fixture at the end of the distal tip measures the distance between the distal tip and the colon wall in three directions, and the actuation system attached at the base of the colonoscope controls the distal tip by rotating two dial knobs. The device controls the distal tip to minimize contact between the distal tip and the colon wall, and the distal tip ideally points out the next possible lumen. A compatibility test of the infrared sensory system was carried out, and the design of the actuation system was accomplished. The system is integrated and controlled by a microprocessor. The device was tested in a silicon colon and porcine intestine. The results showed that a colonoscopist successfully reached the cecum with the aid of the colonoscopy add-on device without significant contact between the colon wall and the distal tip. The colonoscopy aid device was very helpful for the novice colonoscopist.Keywords: colonoscope, infrared sensors, intubation, trauma, colonoscopy training model

  5. Improvement of aquaponic performance through micro- and macro-nutrient addition.

    Science.gov (United States)

    Ru, Dongyun; Liu, Jikai; Hu, Zhen; Zou, Yina; Jiang, Liping; Cheng, Xiaodian; Lv, Zhenting

    2017-07-01

    Aquaponics is one of the "zero waste" industry in the twenty-first century, and is considered to be one of the major trends for the future development of agriculture. However, the low nitrogen utilization efficiency (NUE) restricted its widely application. To date, many attempts have been conducted to improve its NUE. In the present study, effect of micro- and macro-nutrient addition on performance of tilapia-pak choi aquaponics was investigated. Results showed that the addition of micro- and macro-nutrients improved the growth of plant directly and facilitated fish physiology indirectly, which subsequently increased NUE of aquaponics from 40.42 to 50.64%. In addition, remarkable lower total phosphorus concentration was obtained in aquaponics with micro- and macro-nutrient addition, which was attributed to the formation of struvite. Most of the added micro-nutrients were enriched in plant root, while macro-nutrients mainly existed in water. Moreover, no enrichment of micro- and macro-nutrients in aquaponic products (i.e., fish and plant leaves) was observed, indicating that it had no influence on food safety. The findings here reported manifest that appropriate addition of micro- and macro-nutrients to aquaponics is necessary, and would improve its economic feasibility.

  6. Recent advances in noninvasive glucose monitoring

    Directory of Open Access Journals (Sweden)

    So CF

    2012-06-01

    Full Text Available Chi-Fuk So,1 Kup-Sze Choi,1 Thomas KS Wong,2 Joanne WY Chung2,31Centre for Integrative Digital Health, School of Nursing, The Hong Kong Polytechnic University, Hong Kong, 2Department of Nursing and Health Sciences, Tung Wah College, Hong Kong, 3Department of Health and Physical Education, The Hong Kong Institute of Education, Hong KongAbstract: The race for the next generation of painless and reliable glucose monitoring for diabetes mellitus is on. As technology advances, both diagnostic techniques and equipment improve. This review describes the main technologies currently being explored for noninvasive glucose monitoring. The principle of each technology is mentioned; its advantages and limitations are then discussed. The general description and the corresponding results for each device are illustrated, as well as the current status of the device and the manufacturer; internet references for the devices are listed where appropriate. Ten technologies and eleven potential devices are included in this review. Near infrared spectroscopy has become a promising technology, among others, for blood glucose monitoring. Although some reviews have been published already, the rapid development of technologies and information makes constant updating mandatory. While advances have been made, the reliability and the calibration of noninvasive instruments could still be improved, and more studies carried out under different physiological conditions of metabolism, bodily fluid circulation, and blood components are needed.Keywords: noninvasive, glucose monitoring, diabetes mellitus, blood glucose measurement

  7. User experiences of wearable activity monitor among 3-6-year-old preschool children – Are children willing to wear monitor 7 days 24 hours per day?

    Directory of Open Access Journals (Sweden)

    Suvi Määttä

    2015-10-01

    This study was conducted as a part of long-term DAGIS project that aims to improve the health behaviors and diminish socioeconomic inequalities in health behaviors among preschool children in Finland. A large cross-sectional survey is conducted in autumn 2015. Children (N=800, aged 3-6 years wear Actigraph WGT3X-BT accelerometer for seven days, 24 hours per day. Simultaneously with accelerometer use, parents fill in diary with informing the user experiences of accelerometer and possible non-wearing times. Parents are advised that the child wears accelerometer 24 hours and remove the belt only when in water (e.g. in shower. The accelerometer data are checked straight after data collection. Choi (2011 wear time analyses are conducted for data. The device acceptability, compliance for wearing times and reported barriers for using accelerometer 24 hours in seven days among 3-6-year-old children are reported. Conclusions This study provides new information about the usability of wearable activity monitors among 3-6-year-old children, an age group that is less studied.

  8. Target Identification Using Harmonic Wavelet Based ISAR Imaging

    Science.gov (United States)

    Shreyamsha Kumar, B. K.; Prabhakar, B.; Suryanarayana, K.; Thilagavathi, V.; Rajagopal, R.

    2006-12-01

    A new approach has been proposed to reduce the computations involved in the ISAR imaging, which uses harmonic wavelet-(HW) based time-frequency representation (TFR). Since the HW-based TFR falls into a category of nonparametric time-frequency (T-F) analysis tool, it is computationally efficient compared to parametric T-F analysis tools such as adaptive joint time-frequency transform (AJTFT), adaptive wavelet transform (AWT), and evolutionary AWT (EAWT). Further, the performance of the proposed method of ISAR imaging is compared with the ISAR imaging by other nonparametric T-F analysis tools such as short-time Fourier transform (STFT) and Choi-Williams distribution (CWD). In the ISAR imaging, the use of HW-based TFR provides similar/better results with significant (92%) computational advantage compared to that obtained by CWD. The ISAR images thus obtained are identified using a neural network-based classification scheme with feature set invariant to translation, rotation, and scaling.

  9. Structural integrity evaluation of X52 gas pipes subjected to external corrosion defects using the SINTAP procedure

    International Nuclear Information System (INIS)

    Adib-Ramezani, H.; Jeong, J.; Pluvinage, G.

    2006-01-01

    In the present study, the SINTAP procedure has been proposed as a general structural integrity tool for semi-spherical, semi-elliptical and long blunt notch defects. The notch stress intensity factor concept and SINTAP structural integrity procedure are employed to assess gas pipelines integrity. The external longitudinal defects have been investigated via elastic-plastic finite element method results. The notch stress intensity concept is implemented into SINTAP procedure. The safety factor is calculated via SINTAP procedure levels 0B and 1B. The extracted evaluations are compared with the limit load analysis based on ASME B31G, modified ASME B31G, DNV RP-F101 and recent proposed formulation [Choi JB, Goo BK, Kim JC, Kim YJ, Kim WS. Development of limit load solutions for corroded gas pipelines. Int J Pressure Vessel Piping 2003;80(2):121-128]. The comparison among extracted safety factors exhibits that SINTAP predictions are located between lower and upper safety factor bounds. The SINTAP procedure including notch-based assessment diagram or so-called 'NFAD' involves wide range of defect geometries with low, moderate and high stress concentrations and relative stress gradients. Finally, some inspired and advanced viewpoints have been investigated

  10. A PANEL COINTEGRATION ANALYSIS: AN APPLICATION TO INTERNATIONAL TOURISM DEMAND OF THAILAND

    Directory of Open Access Journals (Sweden)

    CHUKIAT CHAIBOONSRI

    2010-01-01

    Full Text Available This paper sought to find the long-run relationships between international tourist arrivals in Thailand and economic variables such as GDP, transportation cost and exchange rates during period of 1986 to 2007. Also this paper used five standard panel unit root tests such as LLC (2002 panel unit root test, Breitung (2000 panel unit root test, IPS (2003 panel unit root test, Maddala and Wu (1999 and Choi (2001 panel unit root test and Handri (1999 panel unit root test. Moreover, the panel cointegration test based on Pedroni residual cointegration tests, Kao residual cointegration tests and Johansen fisher panel cointegration test were used to test in panel among the variables. The OLS estimator, DOLS estimator and FMOLS estimator were used to find the long-run relationship of the international tourism demand model for Thailand.The long-run results indicated that growth in income (GDP of Thai’s Asia major tourist source markets (Malaysia, Japan, Korea, China, Singapore and Taiwan have a positive impact on international tourists arrival to Thailand. In addition, the transportation cost of these countries has negative impact on the number of international tourist arrivals to Thailand. Finally Thailand’s currency has positive impact on the number of international tourist arrivals to Thailand. Most of findings from this study were consistent with economic theory and the implications of the model can be use for policy making.

  11. Prediction of fracture strength in Al2O3/SiCp ceramic matrix nanocomposites

    Directory of Open Access Journals (Sweden)

    Z. Zhang and D.L. Chen

    2007-01-01

    Full Text Available Based primarily on a recent publication [S.M. Choi, H. Awaji, Sci. Tech. Adv. Mater. 6 (2005 2–10.], where the dislocations around the nano-sized particles in the intra-granular type of ceramic matrix nanocomposites (CMNCs were modeled, dislocation activities in Al2O3/SiCp CMNCs were discussed in relation to the processing conditions. The dislocations around the nano-sized particles, caused by the thermal mismatch between the ceramic matrix and nano-sized particles, were assumed to hold out the effect of Orowan-like strengthening, although the conventional Owowan loops induced by the movement of dislocations were unlikely in the ceramic matrix at room temperature. A model involving the yield strength of metal matrix nanocomposites (MMNCs, where the Owowan strengthening effect was taken into consideration, was thus modified and extended to predict the fracture strength of the intra-granular type of CMNCs without and with annealing. On the basis of the characteristics of dislocations in the CMNCs, the load-bearing effect and Orowan-like strengthening were considered before annealing, while the load-bearing effect and enhanced dislocation density strengthening were taken into account after annealing. The model prediction was found to be in agreement with the experimental data of Al2O3/SiCp nanocomposites reported in the literature.

  12. Experimental type 2 diabetes mellitus and acetaminophen toxic lesions: glutathione system indices changes

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    Olga Furka

    2017-11-01

    Full Text Available Background. The goal of the research was to study the effect of acetaminophen on major glutathione part of antioxidant system indices in liver homogenate of rats with type 2 diabetes mellitus in time dynamics. Materials and methods. We conducted two series of experiments. In the first series toxic lesion was caused by a single intragastric administration of acetaminophen suspension in 2 % starch solution to animals in a dose of 1250 mg/kg (1/2 LD50. In the second series  the suspension of acetaminophen in 2 % starch solution in a dose of 55 mg/kg was given, which corresponds to the highest therapeutic dose during 7 days. Non-genetic form of experimental type 2 diabetes mellitus was modeled by Islam S., Choi H. method (2007. Activity of glutathione peroxidase (GPx and glutathione reductase (GR, and contents of reduced glutathione (GSH were determined in liver homogenate. Results. The obtained results have shown that GR and GPx activity actively decreased after acetaminophen administration in higher therapeutic doses to rats with type 2 DM. However, the changes were less pronounced than in rats with type 2 DM and acute acetaminophen toxic lesions. Conclusion. Results of the research have shown that acetaminophen administration to rats with type 2 DM causes a significant violation of compensatory mechanisms, especially of the enzyme and nonenzyme parts of antioxidant system.

  13. Channel Simulation in Quantum Metrology

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    Laurenza Riccardo

    2018-04-01

    Full Text Available In this review we discuss how channel simulation can be used to simplify the most general protocols of quantum parameter estimation, where unlimited entanglement and adaptive joint operations may be employed. Whenever the unknown parameter encoded in a quantum channel is completely transferred in an environmental program state simulating the channel, the optimal adaptive estimation cannot beat the standard quantum limit. In this setting, we elucidate the crucial role of quantum teleportation as a primitive operation which allows one to completely reduce adaptive protocols over suitable teleportation-covariant channels and derive matching upper and lower bounds for parameter estimation. For these channels,wemay express the quantum Cramér Rao bound directly in terms of their Choi matrices. Our review considers both discrete- and continuous-variable systems, also presenting some new results for bosonic Gaussian channels using an alternative sub-optimal simulation. It is an open problem to design simulations for quantum channels that achieve the Heisenberg limit.

  14. Sustained Local Diversity of Vibrio cholerae O1 Biotypes in a Previously Cholera-Free Country.

    Science.gov (United States)

    Boucher, Yan

    2016-05-03

    Although the current cholera pandemic can trace its origin to a specific time and place, many variants of Vibrio cholerae have caused this disease over the last 50 years. The relative clinical importance and geographical distribution of these variants have changed with time, but most remain in circulation. Some countries, such as Mexico and Haiti, had escaped the current pandemic, until large epidemics struck them in 1991 and 2010, respectively. Cholera has been endemic in these countries ever since. A recent retrospective study in mBio presents the results of more than 3 decades of V. cholerae monitoring from environmental and clinical sources in Mexico (S. Y. Choi et al., mBio 7:e02160-15, 2016, http://dx.doi.org/10.1128/mBio.02160-15). It reveals that multiple V. cholerae variants, including classical strains from the previous pandemic, as well as completely novel biotypes, have been circulating in Mexico. This discovery has important implications for the epidemiology and evolution of V. cholerae. Copyright © 2016 Boucher.

  15. Sustained Local Diversity of Vibrio cholerae O1 Biotypes in a Previously Cholera-Free Country

    Directory of Open Access Journals (Sweden)

    Yan Boucher

    2016-07-01

    Full Text Available Although the current cholera pandemic can trace its origin to a specific time and place, many variants of Vibrio cholerae have caused this disease over the last 50 years. The relative clinical importance and geographical distribution of these variants have changed with time, but most remain in circulation. Some countries, such as Mexico and Haiti, had escaped the current pandemic, until large epidemics struck them in 1991 and 2010, respectively. Cholera has been endemic in these countries ever since. A recent retrospective study in mBio presents the results of more than 3 decades of V. cholerae monitoring from environmental and clinical sources in Mexico (S. Y. Choi et al., mBio 7:e02160-15, 2016, http://dx.doi.org/10.1128/mBio.02160-15. It reveals that multiple V. cholerae variants, including classical strains from the previous pandemic, as well as completely novel biotypes, have been circulating in Mexico. This discovery has important implications for the epidemiology and evolution of V. cholerae.

  16. Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem, Jiafu Cao, Moonjeong Choi, Woo Seong Kim, Hyung Ryong Moon, Bok Luel Lee, Min-Soo Kim, Yunjin Jung, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Current colon-targeted drug-delivery approaches for colitis therapy often utilize single pH-triggered systems, which are less reliable due to the variation of gut pH in individuals and in disease conditions. Herein, we prepared budesonide-loaded dual-sensitive nanoparticles using enzyme-sensitive azo-polyurethane and pH-sensitive methacrylate copolymer for the treatment of colitis. The therapeutic potential of the enzyme/pH dual-sensitive nanoparticles was evaluated using a rat colitis model and compared to single pH-triggered nanoparticles. Clinical activity scores, colon/body weight ratios, myeloperoxidase activity, and proinflammatory cytokine levels were markedly decreased by dual-sensitive nanoparticles compared to single pH-triggered nanoparticles and budesonide solution. Moreover, dual-sensitive nanoparticles accumulated selectively in inflamed segments of the colon. In addition, dual-sensitive nanoparticle plasma concentrations were lower than single pH-triggered nanoparticles, and no noticeable in vitro or in vivo toxicity was observed. Our results demonstrate that enzyme/pH dual-sensitive nanoparticles are an effective and safe colon-targeted delivery system for colitis therapy. Keywords: azo-polyurethane, methacrylate copolymer, budesonide, colon-targeted nanoparticles, colitis

  17. EQUIVALENCIA DEL ESPESOR DE ENSUCIAMIENTO CON β-lg DESNATURALIZADA EN EL CALENTAMIENTO DE LECHE

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    Heriberto Molina Pérez

    2015-01-01

    Full Text Available En este trabajo se presenta un a estrategia para relacionar ,a través de un modelo matemático, el espesor de ensuciamiento de alimentos lácteos y la concentración de β - lg (β - lactoglobulina desnaturali zada . El planteamiento incluye , por una parte,la simulaci ón dinámica de ensuciamiento y, por otra, la generación de β - lg desnaturalizada bajo un modelo cinético. En ambos caso s se realizó un balance de energía en estado transitorio que incluye los cálculos del coeficiente global , de forma rigurosa, y de las propiedades, bajo el modelo de Choi - Okos. La solución de fue obtenida usando Runge - Kut ta 4to orden bajo código propio en una Macro de Excel en Visual Basic . La equivalencia concluyó con un modelo obtenido por regresión múltipl e no - lineal que relaciona la concentración de β - lg desnaturalizada y el espesor de ensuciamiento . Esta metodología es aplicable en el análisis de limpieza de equipos donde la cinética de limpieza puede obtener equivalencia con el avance de la reducción del espesor de ensuciamiento .

  18. Cultural Attitudes as WTP Determinants: A Revised Cultural Worldview Scale

    Directory of Open Access Journals (Sweden)

    Andy S. Choi

    2016-06-01

    Full Text Available There has been little attention paid to the systematic measurement issue of general attitudes toward human-culture relationships. This paper applied the Cultural Worldview (CW scale that was developed by Choi et al. in 2007 (published in the Journal of Cultural Economics, and investigated its dimensionality and relationship with willingness to pay (WTP for cultural heritage protection through a sequential integration between latent variables and valuation models. A case study of 997 Korean respondents was employed to examine conservation values of cultural heritage sites using discrete choice models. Confirmatory factor analyses demonstrated that this scale can be used either as a single second-order factor or four correlated factors. A more parsimonious version of the CW scale with twelve items is endorsed in this paper and the results also confirm that it is valid for use with non-Western nations. The findings support a significant attitude–WTP relationship; there was a significant role of the CW scale that reveals unobserved factors in valuation models.

  19. Characterization of a novel yeast species Metschnikowia persimmonesis KCTC 12991BP (KIOM G15050 type strain) isolated from a medicinal plant, Korean persimmon calyx (Diospyros kaki Thumb).

    Science.gov (United States)

    Kang, Young Min; Choi, Ji Eun; Komakech, Richard; Park, Jeong Hwan; Kim, Dae Wook; Cho, Kye Man; Kang, Seung Mi; Choi, Sang Haeng; Song, Kun Chul; Ryu, Chung Min; Lee, Keun Chul; Lee, Jung-Sook

    2017-11-10

    The yeast strain Metschnikowia persimmonesis Kang and Choi et al., sp. nov. [type strain KIOM_G15050 = Korean Collection for Type Cultures (KCTC) 12991BP] was isolated from the stalk of native persimmon cultivars (Diospyros kaki Thumb) obtained from different regions of South Korea and was characterized phenotypically, genetically, and physiologically. The isolate grew between 4 and 40 °C (optimum temperature: 24-28 °C), pH 3-8 (pH optimum = 6.0), and in 0-4% NaCl solution (with optimal growth in absence of NaCl). It also exhibited strong antibiotic and antimicrobial activities. Morphologically, cells were characterized by the presence of long, needle-shaped ascospores. Based on 18S ribosomal DNA gene sequence analysis, the new species was found to belong to the genus Metschnikowia as a sister clade of Metschnikowia fructicola. We therefore conclude that this yeast isolate from D. kaki is a new member of the genus Metschnikowia and propose the name M. persimmonesis sp. nov. This strain has been deposited in the KCTC for future reference. This discovery provides a basis for future research on M. persimmonesis sp. nov., including its possible contribution to the medicinal properties of the host persimmon plant.

  20. A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

    Directory of Open Access Journals (Sweden)

    Choi J

    2014-05-01

    Full Text Available Jonghoon Choi,1,2 Mintai P Hwang,3 Jong-Wook Lee,3 Kwan Hyi Lee3,41Institute of Research Strategy and Development (IRSD, Seoul, Republic of Korea; 2Department of Bionano Engineering, Hanyang University, Ansan, Republic of Korea; 3Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Biomedical Engineering, University of Science and Technology, Seoul, Republic of KoreaAbstract: Mesenchymal stem cells (MSCs have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.Keywords: mesenchymal stem cell, T cell, microwell array

  1. Effect of Solid Biological Waste Compost on the Metabolite Profile of Brassica rapa ssp. chinensis

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    Susanne Neugart

    2018-03-01

    Full Text Available Large quantities of biological waste are generated at various steps within the food production chain and a great utilization potential for this solid biological waste exists apart from the current main usage for the feedstuff sector. It remains unclear how the usage of biological waste as compost modulates plant metabolites. We investigated the effect of biological waste of the processing of coffee, aronia, and hop added to soil on the plant metabolite profile by means of liquid chromatography in pak choi sprouts. Here we demonstrate that the solid biological waste composts induced specific changes in the metabolite profiles and the changes are depending on the type of the organic residues and its concentration in soil. The targeted analysis of selected plant metabolites, associated with health beneficial properties of the Brassicaceae family, revealed increased concentrations of carotenoids (up to 3.2-fold and decreased amounts of glucosinolates (up to 4.7-fold as well as phenolic compounds (up to 1.5-fold.

  2. Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi.

    Science.gov (United States)

    Malik, Jai; Karan, Maninder; Vasisht, Karan

    2011-12-01

    Shankhpushpi, a well-known drug in Ayurveda, is extensively used for different central nervous system (CNS) effects especially memory enhancement. Different plants are used under the name shankhpushpi in different regions of India, leading to an uncertainty regarding its true source. Plants commonly used under the name shankhpushpi are: Convolvulus pluricaulis Chois., Evolvulus alsinoides Linn., both from Convolvulaceae, and Clitoria ternatea Linn. (Leguminosae). To find out the true source of shankhpushpi by evaluating and comparing memory-enhancing activity of the three above mentioned plants. Anxiolytic, antidepressant and CNS-depressant activities of these three plants were also compared and evaluated. The nootropic activity of the aqueous methanol extract of each plant was tested using elevated plus-maze (EPM) and step-down models. Anxiolytic, antidepressant and CNS-depressant studies were evaluated using EPM, Porsolt?s swim despair and actophotometer models, respectively. C. pluricaulis extract (CPE) at a dose of 100 mg/kg, p.o. showed maximum nootropic and anxiolytic activity (p nootropic, anxiolytic and CNS-depressant activity. The results of memory-enhancing activity suggest C. pluricaulis to be used as true source of shankhpushpi.

  3. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543

    Science.gov (United States)

    Jokela, Jouni; Heinilä, Lassi M. P.; Shishido, Tânia K.; Wahlsten, Matti; Fewer, David P.; Fiore, Marli F.; Wang, Hao; Haapaniemi, Esa; Permi, Perttu; Sivonen, Kaarina

    2017-01-01

    Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds. Here we report the production of hepatotoxins and new protease inhibitors from benthic Nostoc sp. CENA543 isolated from a small, shallow, saline-alkaline lake in the Nhecolândia, Pantanal wetland area in Brazil. Nostoc sp. CENA543 produces exceptionally high amounts of nodularin-R. This is the first free-living Nostoc that produces nodularin at comparable levels as the toxic, bloom-forming, Nodularia spumigena. We also characterized pseudospumigins A–F, which are a novel family of linear tetrapeptides. Pseudospumigins are structurally related to linear tetrapeptide spumigins and aeruginosins both present in N. spumigena but differ in respect to their diagnostic amino acid, which is Ile/Leu/Val in pseudospumigins, Pro/mPro in spumigins, and Choi in aeruginosins. The pseudospumigin gene cluster is more similar to the spumigin biosynthetic gene cluster than the aeruginosin gene cluster. Pseudospumigin A inhibited trypsin (IC50 4.5 μM after 1 h) in a similar manner as spumigin E from N. spumigena but was almost two orders of magnitude less potent. This study identifies another location and environment where the hepatotoxic nodularin has the potential to cause the death of eukaryotic organisms. PMID:29062311

  4. Factors influencing post-traumatic stress in Korean forensic science investigators.

    Science.gov (United States)

    Yoo, Yang-Sook; Cho, Ok-Hee; Cha, Kyeong-Sook; Boo, Yun-Jeong

    2013-09-01

    The aim of this study was to understand factors that influence post-traumatic stress (PTS) in Korean forensic science investigators. A total of 111 forensic science investigators were recruited in Korea. PTS was measured using the tool modified by Choi (2001) from the original developed by Foa, Riggs, Dancu, and Rothbaum (1993) based on DSM-IV. Factors influencing PTS included demographic and job-related characteristics, emotional intelligence, and death anxiety. PTS scores were positively correlated with personality type, fatigue from work, and death anxiety. PTS scores were negatively correlated with length of career as a forensic science investigator and emotional intelligence. The factors that had the greatest influence on PTS were death anxiety, years spent as a forensic science investigator, personality type, emotional intelligence, fatigue, and homicide experience. The explanatory power of these six factors was 44.0%. Therefore, it is necessary to regularly evaluate the mental health of those who are vulnerable to PTS. Based on these results, various interventions could be implemented for promoting overall health of the forensic science investigators. Copyright © 2013. Published by Elsevier B.V.

  5. WHO Standard Acupuncture Point Locations

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    Sabina Lim

    2010-01-01

    Full Text Available ‘WHO Standard Acupuncture Point Locations in the Western Pacific Region (WHO Standard was released in 2008. Initially, there were 92/361 controversial acupuncture points (acupoints. Through seven informal consultations and four task force team meetings, 86 points were agreed upon among the 92 controversial acupoints, leaving 6 remaining controversial acupoints, demanding active research in the future. This will enhance the reproducibility and validity of acupuncture studies. It will also lead to a better understanding of acupuncture mechanisms in order to optimize its clinical efficacy for a range of diseases and syndromes. This book has two parts: General Guidelines for Acupuncture Point Locations and WHO Standard Acupuncture Point Locations. First of all, familiarity with the General Guidelines for Acupuncture Point Locations in this book can help the reader to understand and use the contents of this book in depth. I would like to thank all of the participating experts and scholars for this great work, who have overcome the limits of previous acupuncture references. I also appreciate the dedicated effort and harmonious leadership of Dr Choi Seung-hoon, former Regional Adviser in Traditional Medicine of Western Pacific Office, WHO.

  6. NHE10, a novel osteoclast-specific member of the Na+/H+ exchanger family, regulates osteoclast differentiation and survival

    International Nuclear Information System (INIS)

    Lee, Seoung Hoon; Kim, Taesoo; Park, Eui-Soon; Yang, Sujeong; Jeong, Daewon; Choi, Yongwon; Rho, Jaerang

    2008-01-01

    Bone homeostasis is tightly regulated by the balanced actions of osteoblasts (OBs) and osteoclasts (OCs). We previously analyzed the gene expression profile of OC differentiation using a cDNA microarray, and identified a novel osteoclastogenic gene candidate, clone OCL-1-E7 [J. Rho, C.R. Altmann, N.D. Socci, L. Merkov, N. Kim, H. So, O. Lee, M. Takami, A.H. Brivanlou, Y. Choi, Gene expression profiling of osteoclast differentiation by combined suppression subtractive hybridization (SSH) and cDNA microarray analysis, DNA Cell Biol. 21 (2002) 541-549]. In this study, we have isolated full-length cDNAs corresponding to this clone from mice and humans to determine the functional roles of this gene in osteoclastogenesis. The full-length cDNA of OCL-1-E7 encodes 12 membrane-spanning domains that are typical of isoforms of the Na + /H + exchangers (NHEs), indicating that this clone is a novel member of the NHE family (hereafter referred to as NHE10). Here, we show that NHE10 is highly expressed in OCs in response to receptor activator of nuclear factor-κB ligand signaling and is required for OC differentiation and survival

  7. Production of High Amounts of Hepatotoxin Nodularin and New Protease Inhibitors Pseudospumigins by the Brazilian Benthic Nostoc sp. CENA543

    Directory of Open Access Journals (Sweden)

    Jouni Jokela

    2017-10-01

    Full Text Available Nostoc is a cyanobacterial genus, common in soils and a prolific producer of natural products. This research project aimed to explore and characterize Brazilian cyanobacteria for new bioactive compounds. Here we report the production of hepatotoxins and new protease inhibitors from benthic Nostoc sp. CENA543 isolated from a small, shallow, saline-alkaline lake in the Nhecolândia, Pantanal wetland area in Brazil. Nostoc sp. CENA543 produces exceptionally high amounts of nodularin-R. This is the first free-living Nostoc that produces nodularin at comparable levels as the toxic, bloom-forming, Nodularia spumigena. We also characterized pseudospumigins A–F, which are a novel family of linear tetrapeptides. Pseudospumigins are structurally related to linear tetrapeptide spumigins and aeruginosins both present in N. spumigena but differ in respect to their diagnostic amino acid, which is Ile/Leu/Val in pseudospumigins, Pro/mPro in spumigins, and Choi in aeruginosins. The pseudospumigin gene cluster is more similar to the spumigin biosynthetic gene cluster than the aeruginosin gene cluster. Pseudospumigin A inhibited trypsin (IC50 4.5 μM after 1 h in a similar manner as spumigin E from N. spumigena but was almost two orders of magnitude less potent. This study identifies another location and environment where the hepatotoxic nodularin has the potential to cause the death of eukaryotic organisms.

  8. Unambiguous Determination of Intermolecular Hydrogen Bond of NMR Structure by Molecular Dynamics Refinement Using All-Atom Force Field and Implicit Solvent Model

    International Nuclear Information System (INIS)

    Jee, Jun Goo

    2010-01-01

    It has been shown that AMD refinement is very useful for defining an intermolecular hydrogen bond in NMR structure calculation. The refined structure also provides a clue for explaining the pH dependence in Ub and UIM complexes. As reported by Choi et al., serine-mediated hydrogen bonds are the third most populated hydrogen bonds found in protein-protein intermolecular interactions, after the backbone-backbone and backbone-aspartate ones. The abundance imposes the requirement of an method to determine the interface of protein-protein complexes. The precise geometry is particularly important in the complex structures between Ub and UBDs. Ub recognizes various targets with the same surface, where both hydrophobic and hydrophobic interactions are involved. Hence, the details of the hydrophilic interactions are necessary to find the common binding modes. The structure determination of a biomolecule by NMR depends heavily on the distance restraints derived by the NOE cross peaks that are observed between two protons within 6 A through space. Therefore, the existence of the NOE peaks and their correct assignments to two corresponding protons are essential for an accurate and precise structure determination. Recent developments of NOE assignment and calculation algorithms have enabled the determination of protein 3D structures without any manual interpretation, provided chemical shifts are assigned in most atoms and sufficient NOE peaks exist. Along with these advances, the necessity of determining complicated structures such as complexes is increasing

  9. Resistance of Newly Introduced Vegetables to Meloidogyne arenaria and M. incognita in Korea

    Directory of Open Access Journals (Sweden)

    Donggeun Kim

    2013-12-01

    Full Text Available To select resistant vegetables against two species of root-knot nematodes, M. incognita and M. arenaria, 39 vegetables belongs to 7 families, 13 genera, 25 species were screened in greenhouse pot test. Susceptible vegetables to both nematodes were amarath and leaf beet in Amaranthaceae, Malabar spinach in Basellaceae, Moroheiya in Tiliaceae, and Water-convolvulus in Convolvulaceae, Pak-choi in Brassica campestris var. chinensis, Tah tasai in B. campestris var. narinosa, B. campestris var. chinensis x narinosa, Leaf mustard, Mustard green in B. juncea, Kyona in B. juncea var. laciniate, Choy sum in B. rapa subsp. arachinenesis, Kairan in B. oleracea var. alboglabra, Arugula in Eruca sativa, Garland chrysanthemum in Chrysanthemum coronarium, Endive in Cichorium endivia, Artichoke in Cynara cardunculus var. scolymus, Lettuce in Lactuca sativa. Resistant to M. arenaria but susceptible to M. incognita were B. oleracea cv. Matjjang kale, B. oleracea var. gongyloides cv. Jeok kohlrabi, and C. intybus cv. Radicchio. Resistant vegetables to both nematodes were C. intybus cv. Sugar loaf, Grumoro, Radichio treviso, B. oleracea cv. Manchu collard, Super matjjang, B. oleracea italica, B. oleracea var. botrytis italiana, and Perilla in Lamiaceae. Vegetables resistant to both species of root-knot nematodes could be used as high-valued rotation crops in greenhouses where root-knot nematodes are problem.

  10. Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

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    Filippo Molinari

    2010-01-01

    Full Text Available Near-infrared spectroscopy (NIRS is a noninvasive system for the real-time monitoring of the concentration of oxygenated (O2Hb and reduced (HHb hemoglobin in the brain cortex. O2Hb and HHb concentrations vary in response to cerebral autoregulation. Sixty-eight women (14 migraineurs without aura, 49 migraineurs with aura, and 5 controls performed breath-holding and hyperventilation during NIRS recordings. Signals were processed using the Choi-Williams time-frequency transform in order to measure the power variation of the very-low frequencies (VLF: 20–40 mHz and of the low frequencies (LF: 40–140 mHz. Results showed that migraineurs without aura present different LF and VLF power levels than controls and migraineurs with aura. The accurate power measurement of the time-frequency analysis allowed for the discrimination of the subjects' hemodynamic patterns. The time-frequency analysis of NIRS signals can be used in clinical practice to assess cerebral hemodynamics.

  11. Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

    Directory of Open Access Journals (Sweden)

    Liboni William

    2010-01-01

    Full Text Available Abstract Near-infrared spectroscopy (NIRS is a noninvasive system for the real-time monitoring of the concentration of oxygenated ( and reduced (HHb hemoglobin in the brain cortex. and HHb concentrations vary in response to cerebral autoregulation. Sixty-eight women (14 migraineurs without aura, 49 migraineurs with aura, and 5 controls performed breath-holding and hyperventilation during NIRS recordings. Signals were processed using the Choi-Williams time-frequency transform in order to measure the power variation of the very-low frequencies (VLF: 20–40 mHz and of the low frequencies (LF: 40–140 mHz. Results showed that migraineurs without aura present different LF and VLF power levels than controls and migraineurs with aura. The accurate power measurement of the time-frequency analysis allowed for the discrimination of the subjects' hemodynamic patterns. The time-frequency analysis of NIRS signals can be used in clinical practice to assess cerebral hemodynamics.

  12. Fuzzy Extractor and Elliptic Curve Based Efficient User Authentication Protocol for Wireless Sensor Networks and Internet of Things

    Directory of Open Access Journals (Sweden)

    Anup Kumar Maurya

    2017-10-01

    Full Text Available To improve the quality of service and reduce the possibility of security attacks, a secure and efficient user authentication mechanism is required for Wireless Sensor Networks (WSNs and the Internet of Things (IoT. Session key establishment between the sensor node and the user is also required for secure communication. In this paper, we perform the security analysis of A.K.Das’s user authentication scheme (given in 2015, Choi et al.’s scheme (given in 2016, and Park et al.’s scheme (given in 2016. The security analysis shows that their schemes are vulnerable to various attacks like user impersonation attack, sensor node impersonation attack and attacks based on legitimate users. Based on the cryptanalysis of these existing protocols, we propose a secure and efficient authenticated session key establishment protocol which ensures various security features and overcomes the drawbacks of existing protocols. The formal and informal security analysis indicates that the proposed protocol withstands the various security vulnerabilities involved in WSNs. The automated validation using AVISPA and Scyther tool ensures the absence of security attacks in our scheme. The logical verification using the Burrows-Abadi-Needham (BAN logic confirms the correctness of the proposed protocol. Finally, the comparative analysis based on computational overhead and security features of other existing protocol indicate that the proposed user authentication system is secure and efficient. In future, we intend to implement the proposed protocol in real-world applications of WSNs and IoT.

  13. Structural integrity evaluation of X52 gas pipes subjected to external corrosion defects using the SINTAP procedure

    Energy Technology Data Exchange (ETDEWEB)

    Adib-Ramezani, H. [Ecole Polytechnique de l' Universite d' Orleans, CNRS-CRMD, 8 rue Leonard de Vinci, 45072 Orleans Cedex 2 (France)]. E-mail: hradib_2000@yahoo.com; Jeong, J. [Ecole Polytechnique de l' Universite d' Orleans, CNRS-CRMD, 8 rue Leonard de Vinci, 45072 Orleans Cedex 2 (France); Pluvinage, G. [Laboratoire de Fiabilite Mecanique (LFM), Universite de Metz-ENIM, 57045 Metz (France)

    2006-06-15

    In the present study, the SINTAP procedure has been proposed as a general structural integrity tool for semi-spherical, semi-elliptical and long blunt notch defects. The notch stress intensity factor concept and SINTAP structural integrity procedure are employed to assess gas pipelines integrity. The external longitudinal defects have been investigated via elastic-plastic finite element method results. The notch stress intensity concept is implemented into SINTAP procedure. The safety factor is calculated via SINTAP procedure levels 0B and 1B. The extracted evaluations are compared with the limit load analysis based on ASME B31G, modified ASME B31G, DNV RP-F101 and recent proposed formulation [Choi JB, Goo BK, Kim JC, Kim YJ, Kim WS. Development of limit load solutions for corroded gas pipelines. Int J Pressure Vessel Piping 2003;80(2):121-128]. The comparison among extracted safety factors exhibits that SINTAP predictions are located between lower and upper safety factor bounds. The SINTAP procedure including notch-based assessment diagram or so-called 'NFAD' involves wide range of defect geometries with low, moderate and high stress concentrations and relative stress gradients. Finally, some inspired and advanced viewpoints have been investigated.

  14. Image, Precariousness and the Logic of Cultural Production in Hong Kong

    Directory of Open Access Journals (Sweden)

    Carolyn Cartier

    2013-01-01

    Full Text Available Interpretations of culture in Hong Kong have tended to portray the city in terms of the vanishing present, in some combination of the instant, fleeting and disappearing. This article redresses such language of lack to consider instead how the idea of precariousness in the realm of the cultural has been less a condition of cultural production than a cultural strategy. Street art, including alternative performance art and political graffiti, has made the city itself the site of roving cultural production: walls, street surfaces and passageways accommodate forms of expression that the city’s cultural institutions have only more recently and uneasily embraced. In these different modes of time-space, contemporary alternative art occupies transitory territory and locates its ‘precariousness’ in lack of definitive status and uncertain future – mimetic conditions of defining culture in Hong Kong society itself. Its measures, by contrast, emerge in Jacques Rancière’s distribution of the sensible: the ways in which they render what is visible, knowable and ultimately sayable. As objects generating negotiation, such contemporary cultural projects anticipate instabilities of the present, identify hegemonic political economic logics and seek modes of resistance. Within these perspectives, this discussion juxtaposes two simultaneous events: the exhibit ‘Memories of King Kowloon’ on the historic graffiti of Tsang Tsou-choi, and the stenciled graffiti of Ai Weiwei in public space during April and May 2011.

  15. Punding following posterior cerebral artery infarction: a case report and review of literature

    Directory of Open Access Journals (Sweden)

    Lin CI

    2017-03-01

    Full Text Available Cho-I Lin,1 Yu-Ching Lin,1–3 Wei-Chih Lien,1 Pei-Chun Hsieh,1 Sheng-Han Lin,1 Ta-Shen Kuan1,2 1Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 2Department of Physical Medicine and Rehabilitation, College of Medicine, National Cheng Kung University, Tainan, Taiwan; 3Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan Introduction: Punding is a complex stereotyped behavior, characterized by excessiveness, non-goal orientation, and repetitiveness. It is mostly associated with Parkinson’s disease, and very few cases in non-Parkinson’s disease have been reported. We report a case of punding associated with supratentorial ischemic stroke.Case presentation: We present a 70-year-old man with left posterior cerebral artery infarction with quetiapine-induced punding manifesting as repetitive unidirectional body turning. Remission of punding behavior ensued after cessation of quetiapine and administration of clonazepam.Conclusion: This case describes the clinical course of quetiapine-induced punding in a patient with left posterior cerebral artery infarction. It suggests clonazepam may serve as a treatment option for poststroke punding. Keywords: punding, stereotyped behavior, stroke, quetiapine, clonazepam

  16. Extremely long-lived magnetic excitations in supported Fe chains

    Science.gov (United States)

    Gauyacq, J. P.; Lorente, N.

    2016-07-01

    We report on a theoretical study of the lifetime of the first excited state of spin chains made of an odd number of Fe atoms on C u2N /Cu (100 ) . Yan, Choi, Burgess, Rolf-Pissarczyk, and Loth [Nat. Nanotech. 10, 40 (2015), 10.1038/nnano.2014.281] recently observed very long lifetimes in the case of F e3 chains. We consider the decay of the first excited state induced by electron-hole pair creation in the substrate. For a finite magnetic field, the two lowest-lying states in the chain have a quasi-Néel state structure. Decay from one state to the other strongly depends on the degree of entanglement of the local spins in the chain. The weak entanglement in the chain accounts for the long lifetimes that increase exponentially with chain length. Despite their apparently very different properties, the behavior of odd and even chains is governed by the same kind of phenomena, in particular entanglement effects. The present results account quite well for the lifetimes recently measured by Yan et al. on F e3 .

  17. Conditional mutual information of bipartite unitaries and scrambling

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Dawei; Hayden, Patrick; Walter, Michael [Stanford Institute for Theoretical Physics, Department of Physics, Stanford University,382 Via Pueblo, Stanford, CA 94305 (United States)

    2016-12-28

    One way to diagnose chaos in bipartite unitary channels is via the tripartite information of the corresponding Choi state, which for certain choices of the subsystems reduces to the negative conditional mutual information (CMI). We study this quantity from a quantum information-theoretic perspective to clarify its role in diagnosing scrambling. When the CMI is zero, we find that the channel has a special normal form consisting of local channels between individual inputs and outputs. However, we find that arbitrarily low CMI does not imply arbitrary proximity to a channel of this form, although it does imply a type of approximate recoverability of one of the inputs. When the CMI is maximal, we find that the residual channel from an individual input to an individual output is completely depolarizing when the other input is maximally mixed. However, we again find that this result is not robust. We also extend some of these results to the multipartite case and to the case of Haar-random pure input states. Finally, we look at the relationship between tripartite information and its Rényi-2 version which is directly related to out-of-time-order correlation functions. In particular, we demonstrate an arbitrarily large gap between the two quantities.

  18. Gold nanoparticles promote osteogenic differentiation in human adipose-derived mesenchymal stem cells through the Wnt/β-catenin signaling pathway

    Directory of Open Access Journals (Sweden)

    Choi SY

    2015-07-01

    Full Text Available Seon Young Choi,1 Min Seok Song,1 Pan Dong Ryu,1 Anh Thu Ngoc Lam,2 Sang-Woo Joo,2 So Yeong Lee1 1Laboratory of Veterinary Pharmacology, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 2Department of Chemistry, Soongsil University, Seoul, South Korea Abstract: Gold nanoparticles (AuNPs are attractive materials for use in biomedicine due to their physical properties. Increasing evidence suggests that several nanoparticles induce the differentiation of human mesenchymal stem cells into osteoblasts and adipocytes. In this study, we hypothesized that chitosan-conjugated AuNPs promote the osteogenic differentiation of human adipose-derived mesenchymal stem cells. For the evaluation of osteogenic differentiation, alizarin red staining, an alamarBlue® assay, and a quantitative real-time polymerase chain reaction analysis were performed. In order to examine specific signaling pathways, immunofluorescence and a western blotting assay were performed. Our results demonstrate that chitosan-conjugated AuNPs increase the deposition of calcium content and the expression of marker genes related to osteogenic differentiation in human adipose-derived mesenchymal stem cells at nontoxic concentrations. These results indicate that chitosan-conjugated AuNPs promote osteogenesis through the Wnt/β-catenin signaling pathway. Therefore, chitosan-conjugated AuNPs can be used as a reagent for promoting bone formation. Keywords: chitosan-conjugated gold nanoparticle, mineralization, nonphosphorylated beta-catenin

  19. The Application of Time-Frequency Methods to HUMS

    Science.gov (United States)

    Pryor, Anna H.; Mosher, Marianne; Lewicki, David G.; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper reports the study of four time-frequency transforms applied to vibration signals and presents a new metric for comparing them for fault detection. The four methods to be described and compared are the Short Time Frequency Transform (STFT), the Choi-Williams Distribution (WV-CW), the Continuous Wavelet Transform (CWT) and the Discrete Wavelet Transform (DWT). Vibration data of bevel gear tooth fatigue cracks, under a variety of operating load levels, are analyzed using these methods. The new metric for automatic fault detection is developed and can be produced from any systematic numerical representation of the vibration signals. This new metric reveals indications of gear damage with all of the methods on this data set. Analysis with the CWT detects mechanical problems with the test rig not found with the other transforms. The WV-CW and CWT use considerably more resources than the STFT and the DWT. More testing of the new metric is needed to determine its value for automatic fault detection and to develop methods of setting the threshold for the metric.

  20. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program.

    Science.gov (United States)

    Lee, Eun Ju; Jan, Arif Tasleem; Baig, Mohammad Hassan; Ashraf, Jalaluddin Mohammad; Nahm, Sang-Soep; Kim, Yong-Woon; Park, So-Young; Choi, Inho

    2016-08-01

    Differentiation of muscle satellite cells (MSCs) involves interaction of the proteins present in the extracellular matrix (ECM) with MSCs to regulate their activity, and therefore phenotype. Herein, we report fibromodulin (FMOD), a member of the proteoglycan family participating in the assembly of ECM, as a novel regulator of myostatin (MSTN) during myoblast differentiation. In addition to having a pronounced effect on the expression of myogenic marker genes [myogenin (MYOG) and myosin light chain 2 (MYL2)], FMOD was found to maintain the transcriptional activity of MSTN Moreover, coimmunoprecipitation and in silico studies performed to investigate the interaction of FMOD helped confirm that it antagonizes MSTN function by distorting its folding and preventing its binding to activin receptor type IIB. Furthermore, in vivo studies revealed that FMOD plays an active role in healing by increasing satellite cell recruitment to sites of injury. Together, these findings disclose a hitherto unrecognized regulatory role for FMOD in MSCs and highlight new mechanisms whereby FMOD circumvents the inhibitory effects of MSTN and triggers myoblast differentiation. These findings offer a basis for the design of novel MSTN inhibitors that promote muscle regeneration after injury or for the development of pharmaceutical agents for the treatment of different muscle atrophies.-Lee, E. J., Jan, A. T., Baig, M. H., Ashraf, J. M., Nahm, S.-S., Kim, Y.-W., Park, S.-Y., Choi, I. Fibromodulin: a master regulator of myostatin controlling progression of satellite cells through a myogenic program. © FASEB.

  1. Comparable Analysis of the Distribution Functions of Runup Heights of the 1896, 1933 and 2011 Japanese Tsunamis in the Sanriku Area

    Science.gov (United States)

    Choi, B. H.; Min, B. I.; Yoshinobu, T.; Kim, K. O.; Pelinovsky, E.

    2012-04-01

    Data from a field survey of the 2011 tsunami in the Sanriku area of Japan is presented and used to plot the distribution function of runup heights along the coast. It is shown that the distribution function can be approximated using a theoretical log-normal curve [Choi et al, 2002]. The characteristics of the distribution functions derived from the runup-heights data obtained during the 2011 event are compared with data from two previous gigantic tsunamis (1896 and 1933) that occurred in almost the same region. The number of observations during the last tsunami is very large (more than 5,247), which provides an opportunity to revise the conception of the distribution of tsunami wave heights and the relationship between statistical characteristics and number of observations suggested by Kajiura [1983]. The distribution function of the 2011 event demonstrates the sensitivity to the number of observation points (many of them cannot be considered independent measurements) and can be used to determine the characteristic scale of the coast, which corresponds to the statistical independence of observed wave heights.

  2. DNA assisted self-assembly of PAMAM dendrimers.

    Science.gov (United States)

    Mandal, Taraknath; Kumar, Mattaparthi Venkata Satish; Maiti, Prabal K

    2014-10-09

    We report DNA assisted self-assembly of polyamidoamine (PAMAM) dendrimers using all atom Molecular Dynamics (MD) simulations and present a molecular level picture of a DNA-linked PAMAM dendrimer nanocluster, which was first experimentally reported by Choi et al. (Nano Lett., 2004, 4, 391-397). We have used single stranded DNA (ssDNA) to direct the self-assembly process. To explore the effect of pH on this mechanism, we have used both the protonated (low pH) and nonprotonated (high pH) dendrimers. In all cases studied here, we observe that the DNA strand on one dendrimer unit drives self-assembly as it binds to the complementary DNA strand present on the other dendrimer unit, leading to the formation of a DNA-linked dendrimer dimeric complex. However, this binding process strongly depends on the charge of the dendrimer and length of the ssDNA. We observe that the complex with a nonprotonated dendrimer can maintain a DNA length dependent inter-dendrimer distance. In contrast, for complexes with a protonated dendrimer, the inter-dendrimer distance is independent of the DNA length. We attribute this observation to the electrostatic complexation of a negatively charged DNA strand with the positively charged protonated dendrimer.

  3. Accessing Secondary Markets as a Capital Source for Energy Efficiency Finance Programs: Program Design Considerations for Policymakers and Administrators

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Martin, E. Fadrhonc [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Thompson, P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-02-01

    Estimates of the total opportunity for investment in cost-effective energy efficiency in the United States are typically in the range of several hundred billion dollars (Choi Granade, et al., 2009 and Fulton & Brandenburg, 2012).1,2 To access this potential, many state policymakers and utility regulators have established aggressive energy efficiency savings targets. Current levels of taxpayer and utility bill-payer funding for energy efficiency is only a small fraction of the total investment needed to meet these targets (SEE Action Financing Solutions Working Group, 2013). Given this challenge, some energy efficiency program administrators are working to access private capital sources with the aim of amplifying the funds available for investment. In this context, efficient access to secondary market capital has been advanced as one important enabler of the energy efficiency industry “at scale.”3 The question of what role secondary markets can play in bringing energy efficiency to scale is largely untested despite extensive attention from media, technical publications, advocates, and others. Only a handful of transactions of energy efficiency loan products have been executed to date, and it is too soon to draw robust conclusions from these deals. At the same time, energy efficiency program administrators and policymakers face very real decisions regarding whether and how to access secondary markets as part of their energy efficiency deployment strategy.

  4. Investigation of thermophysical properties of nanofluids; Investigação de propriedades termofísicas de nanofluidos

    Energy Technology Data Exchange (ETDEWEB)

    Vieira, Tiago A.S.; Vidal, Guilherme A.M.; Macedo, Gleydson A., E-mail: tiago.vieira.eng@gmail.com, E-mail: gvidal.ufmg@gmail.com, E-mail: gleydsonam@ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Santos, André A.C. dos; Silva Junior, Geraldo E., E-mail: aacs@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2017-07-01

    In the present study the thermal conductivities and viscosities of some nanofluids were evaluated. Four water-based nanofluids containing solid particulates were studied. The solid particulates used were titanium oxide (TiO{sub 2}), aluminum oxide (Al{sub 2}O{sub 3}), iron oxide (Fe{sub 3}O{sub 4}) and graphene. For this evaluation, we used experimental values available in journals and values calculated by theoretical models. For thermal conductivity theoretical models used were Maxwell, Hamilton and Crosser, Shukla and Dhir, Yu and Choi, Patel and Murshed; for viscosity the theoretical models used were Einstein, Brinkman, Batchelor, Krigger and Dowgherty, Kulkarni and Nielsen. The effects of nanoparticle concentration and temperature on the properties of fluids were raised. Four volume concentrations were used for each fluid. The concentrations used were different for each fluid, according to availability in the literature. Comparisons were made between the theoretical models for the chosen properties with their experimental values. The comparisons between models and experiments were made with the intention of selecting the best model to predict the chosen properties values and, consequently, to evaluate potential applications in the area of nuclear reactors.

  5. An experimental assessment of resistance reduction and wake modification of a kvlcc model by using outer-layer vertical blades

    Directory of Open Access Journals (Sweden)

    An Nam Hyun

    2014-03-01

    Full Text Available In this study, an experimental investigation has been made of the applicability of outer-layer vertical blades to real ship model. After first devised by Hutchins and Choi (2003, the outer-layer vertical blades demonstrated its effectiveness in reducing total drag of flat plate (Park et al., 2011 with maximum drag reduction of 9.6%. With a view to assessing the effect in the flow around a ship, the arrays of outer-layer vertical blades have been installed onto the side bottom and flat bottom of a 300k KVLCC model. A series of towing tank test has been carried out to investigate resistance (CTM reduction efficiency and improvement of stern wake distribution with varying geometric parameters of the blades array. The installation of vertical blades led to the CTM reduction of 2.15~2.76% near the service speed. The nominal wake fraction was affected marginally by the blades array and the axial velocity distribution tended to be more uniform by the blades array.

  6. An experimental assessment of resistance reduction and wake modification of a KVLCC model by using outer-layer vertical blades

    Directory of Open Access Journals (Sweden)

    Nam Hyun An

    2014-03-01

    Full Text Available In this study, an experimental investigation has been made of the applicability of outer-layer vertical blades to real ship model. After first devised by Hutchins and Choi (2003, the outer-layer vertical blades demonstrated its effectiveness in reducing total drag of flat plate (Park et al., 2011 with maximum drag reduction of 9.6%. With a view to assessing the effect in the flow around a ship, the arrays of outer-layer vertical blades have been installed onto the side bottom and flat bottom of a 300k KVLCC model. A series of towing tank test has been carried out to investigate resistance (CTM reduction efficiency and improvement of stern wake distribution with varying geometric parameters of the blades array. The installation of vertical blades led to the CTM reduction of 2.15∼2.76% near the service speed. The nominal wake fraction was affected marginally by the blades array and the axial velocity distribution tended to be more uniform by the blades array.

  7. Utilization of artificial recharged effluent for irrigation: pollutants' removal and risk assessment

    Directory of Open Access Journals (Sweden)

    Liangliang Wei

    2017-03-01

    Full Text Available The reclaimed water from soil aquifer treatment (SAT column was reused for irrigation as the source water, pollutants' removal and health risk assessment was analyzed via the comparison with secondary and tertiary effluents. The effect of the SAT pre-treatment on the qualities and growth of different crops (Lachca sativa – lettuce, Brasica rapa var chinensis – pak choi, Cucumis sativus – cucumber, Brassica oleracea – cabbage, and Zea mays – maize were evaluated. Experimental results demonstrated that the tertiary and SAT treatments had no significant effect on the crop qualities, and could efficiently decrease the accumulation of heavy metals (especially for SAT pre-treatment. Moreover, the carcinogenic risk of the chemical carcinogens for the 1.5 m SAT effluent irrigation declined roughly an order of magnitude as compared with the secondary effluent, and three to four orders of magnitude decreasing of the virus risk. These findings are significant for the safe and cheap reuse of secondary effluent for irrigation purposes.

  8. Investigation of thermophysical properties of nanofluids

    International Nuclear Information System (INIS)

    Vieira, Tiago A.S.; Vidal, Guilherme A.M.; Macedo, Gleydson A.; Santos, André A.C. dos; Silva Junior, Geraldo E.

    2017-01-01

    In the present study the thermal conductivities and viscosities of some nanofluids were evaluated. Four water-based nanofluids containing solid particulates were studied. The solid particulates used were titanium oxide (TiO 2 ), aluminum oxide (Al 2 O 3 ), iron oxide (Fe 3 O 4 ) and graphene. For this evaluation, we used experimental values available in journals and values calculated by theoretical models. For thermal conductivity theoretical models used were Maxwell, Hamilton and Crosser, Shukla and Dhir, Yu and Choi, Patel and Murshed; for viscosity the theoretical models used were Einstein, Brinkman, Batchelor, Krigger and Dowgherty, Kulkarni and Nielsen. The effects of nanoparticle concentration and temperature on the properties of fluids were raised. Four volume concentrations were used for each fluid. The concentrations used were different for each fluid, according to availability in the literature. Comparisons were made between the theoretical models for the chosen properties with their experimental values. The comparisons between models and experiments were made with the intention of selecting the best model to predict the chosen properties values and, consequently, to evaluate potential applications in the area of nuclear reactors

  9. Regional Deprivation Index and Socioeconomic Inequalities Related to Infant Deaths in Korea.

    Science.gov (United States)

    Yun, Jae-Won; Kim, Young-Ju; Son, Mia

    2016-04-01

    Deprivation indices have been widely used to evaluate neighborhood socioeconomic status and therefore examine individuals within their regional context. Although some studies on the development of deprivation indices were conducted in Korea, additional research is needed to construct a more valid and reliable deprivation index. Therefore, a new deprivation index, named the K index, was constructed using principal component analysis. This index was compared with the Carstairs, Townsend and Choi indices. A possible association between infant death and deprivation was explored using the K index. The K index had a higher correlation with the infant mortality rate than did the other three indices. The regional deprivation quintiles were unequally distributed throughout the country. Despite the overall trend of gradually decreasing infant mortality rates, inequalities in infant deaths according to the deprivation quintiles persisted and widened. Despite its significance, the regional deprivation variable had a smaller effect on infant deaths than did individual variables. The K index functions as a deprivation index, and we may use this index to estimate the regional socioeconomic status in Korea. We found that inequalities in infant deaths according to the time trend persisted. To reduce the health inequalities among infants in Korea, regional deprivation should be considered.

  10. Digital Watermarks Using Discrete Wavelet Transformation and Spectrum Spreading

    Directory of Open Access Journals (Sweden)

    Ryousuke Takai

    2003-12-01

    Full Text Available In recent tears, digital media makes rapid progress through the development of digital technology. Digital media normally assures fairly high quality, nevertheless can be easily reproduced in a perfect form. This perfect reproducibility takes and advantage from a certain point of view, while it produces an essential disadvantage, since digital media is frequently copied illegally. Thus the problem of the copyright protection becomes a very important issue. A solution of this problem is to embed digital watermarks that is not perceived clearly by usual people, but represents the proper right of original product. In our method, the images data in the frequency domain are transformed by the Discrete Wavelet Transform and analyzed by the multi resolution approximation, [1]. Further, the spectrum spreading is executed by using PN-sequences. Choi and Aizawa [7] embed watermarks by using block correlation of DCT coefficients. Thus, we apply Discrete Cosine Transformation, abbreviated to DCT, instead of the Fourier transformation in order to embed watermarks.If the value of this variance is high then we decide that the block has bigger magnitude for visual fluctuations. Henceforth, we may embed stronger watermarks, which gives resistance for images processing, such as attacks and/or compressions.

  11. Analytical and Mathematical Modeling and Optimization of Fiber Metal Laminates (FMLs subjected to low-velocity impact via combined response surface regression and zero-One programming

    Directory of Open Access Journals (Sweden)

    Faramarz Ashenai Ghasemi

    Full Text Available This paper presents analytical and mathematical modeling and optimization of the dynamic behavior of the fiber metal laminates (FMLs subjected to low-velocity impact. The deflection to thickness (w/h ratio has been identified through the governing equations of the plate that are solved using the first-order shear deformation theory as well as the Fourier series method. With the help of a two degrees-of-freedom system, consisting of springs-masses, and the Choi's linearized Hertzian contact model the interaction between the impactor and the plate is modeled. Thirty-one experiments are conducted on samples of different layer sequences and volume fractions of Al plies in the composite Structures. A reliable fitness function in the form of a strict linear mathematical function constructed. Using an ordinary least square method, response regression coefficients estimated and a zero-one programming technique proposed to optimize the FML plate behavior subjected to any technological or cost restrictions. The results indicated that FML plate behavior is highly affected by layer sequences and volume fractions of Al plies. The results also showed that, embedding Al plies at outer layers of the structure significantly results in a better response of the structure under low-velocity impact, instead of embedding them in the middle or middle and outer layers of the structure.

  12. Absolute continuity for operator valued completely positive maps on C∗-algebras

    Science.gov (United States)

    Gheondea, Aurelian; Kavruk, Ali Şamil

    2009-02-01

    Motivated by applicability to quantum operations, quantum information, and quantum probability, we investigate the notion of absolute continuity for operator valued completely positive maps on C∗-algebras, previously introduced by Parthasarathy [in Athens Conference on Applied Probability and Time Series Analysis I (Springer-Verlag, Berlin, 1996), pp. 34-54]. We obtain an intrinsic definition of absolute continuity, we show that the Lebesgue decomposition defined by Parthasarathy is the maximal one among all other Lebesgue-type decompositions and that this maximal Lebesgue decomposition does not depend on the jointly dominating completely positive map, we obtain more flexible formulas for calculating the maximal Lebesgue decomposition, and we point out the nonuniqueness of the Lebesgue decomposition as well as a sufficient condition for uniqueness. In addition, we consider Radon-Nikodym derivatives for absolutely continuous completely positive maps that, in general, are unbounded positive self-adjoint operators affiliated to a certain von Neumann algebra, and we obtain a spectral approximation by bounded Radon-Nikodym derivatives. An application to the existence of the infimum of two completely positive maps is indicated, and formulas in terms of Choi's matrices for the Lebesgue decomposition of completely positive maps in matrix algebras are obtained.

  13. Gyrokinetic simulation study of magnetic island effects on neoclassical physics and micro-instabilities in a realistic KSTAR plasma

    Science.gov (United States)

    Kwon, Jae-Min; Ku, S.; Choi, M. J.; Chang, C. S.; Hager, R.; Yoon, E. S.; Lee, H. H.; Kim, H. S.

    2018-05-01

    We perform gyrokinetic simulations to study the effects of a stationary magnetic island on neoclassical flow and micro-instability in a realistic KSTAR plasma condition. Through the simulations, we aim to analyze a recent KSTAR experiment, which was to measure the details of poloidal flow and fluctuation around a stationary (2, 1) magnetic island [M. J. Choi et al., Nucl. Fusion 57, 126058 (2017)]. From the simulations, it is found that the magnetic island can significantly enhance the equilibrium E × B flow. The corresponding flow shearing is strong enough to suppress a substantial portion of ambient micro-instabilities, particularly ∇Te -driven trapped electron modes. This implies that the enhanced E × B flow can sustain a quasi-internal transport barrier for Te in an inner region neighboring the magnetic island. The enhanced E × B flow has a (2, 1) mode structure with a finite phase shift from the mode structure of the magnetic island. It is shown that the flow shear and the fluctuation suppression patterns implied from the simulations are consistent with the observations on the KSTAR experiment.

  14. Coherent tunneling of atoms from Bose-condensed gases at finite temperatures

    International Nuclear Information System (INIS)

    Luxat, David L.; Griffin, Allan

    2002-01-01

    Tunneling of atoms between two trapped Bose-condensed gases at finite temperatures is explored using a many-body linear-response tunneling formalism similar to that used in superconductors. To lowest order, the tunneling currents can be expressed quite generally in terms of the single-particle Green's functions of isolated Bose gases. A coherent first-order tunneling Josephson current between two atomic Bose-Einstein condensates is found, in addition to coherent and dissipative contributions from second-order condensate-noncondensate and noncondensate-noncondensate tunneling. Our work is a generalization of Meier and Zwerger, who recently treated tunneling between uniform atomic Bose gases. We apply our formalism to the analysis of an out-coupling experiment induced by light wave fields, using a simple Bogoliubov-Popov quasiparticle approximation for the trapped Bose gas. For tunneling into the vacuum, we recover the results of Japha, Choi, Burnett, and Band, who recently pointed out the usefulness of studying the spectrum of out-coupled atoms. In particular, we show that the small tunneling current of noncondensate atoms from a trapped Bose gas has a broad spectrum of energies, with a characteristic structure associated with the Bogoliubov quasiparticle u 2 and v 2 amplitudes

  15. A research proposal for investigating the effect of foreign direct investments on technology transfer in the Arabian Gulf (GCC)

    Science.gov (United States)

    Tahat, Kaher; Whelan, Susan

    2015-02-01

    In terms of hosting countries perspectives, Foreign Direct Investments (FDI) could have a positive effect on its developing economy, by transferring, both: resources of finance in addition to the international technology (ITT) (Choi, 1997). Multinational companies (MNC) are engaging in the transferring of the new technology, internally as well as licensing older one; they create "Spillover" (Knowledge) for facilitating the transfer of ITT in line with geographical location, period of investment, and the type of industry. Furthermore, the effect of these spillovers depends on the level of transferring this knowledge based on FDI attraction policies of the host country (Huang, 2009). Considering the Arabian Gulf council countries (GCC) as "FDI- rich hosting countries", who are not seeking for financial resources, i.e., they already have a huge financial capacity for funding their different projects, even though FDI has been powerfully presented in GCC . They saw noticeable increases in FDI inflows beginning in 2002, (www.unctad.org.fdistatistics). Therefore by assumption, FDI inflows to GCC could positively affect their economic growth through transferring the advanced technology, in order to build up their level of technology (productivity growth) as well as their economic diversification strategy. If so how this Knowledge could be diffused and measured in order to maximize its benefit and enhancing the productivity growth, and what is the current status of (GCC).

  16. Negative pressure pulmonary edema after nasal fracture reduction in an obese female patient: a case report

    Directory of Open Access Journals (Sweden)

    Choi EK

    2015-08-01

    Full Text Available Eunkyung Choi,1 Junggu Yi,1 Younghoon Jeon,2 1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea; 2Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea Abstract: Postoperative negative pressure pulmonary edema (NPPE is a rare, but well-known life-threatening complication of acute upper airway obstruction (UAO which develops after general anesthesia. The pronounced inspiratory efforts following UAO lead to excessive negative inspiratory pressure, which may cause acute pulmonary edema. Early recognition and prompt treatment of NPPE is necessary to prevent patient morbidity and mortality. In addition, the physician should carefully manage the patient who has risk factors of UAO to prevent this situation. We experienced a case of NPPE following laryngospasm after tracheal extubation in an obese patient who underwent open reduction of orbital wall and nasal bone surgery. Keywords: airway obstruction, negative pressure pulmonary edema, laryngospasm, nasal surgery, obese

  17. Quantum resource theory of non-stabilizer states in the one-shot regime

    Science.gov (United States)

    Ahmadi, Mehdi; Dang, Hoan; Gour, Gilad; Sanders, Barry

    Universal quantum computing is known to be impossible using only stabilizer states and stabilizer operations. However, addition of non-stabilizer states (also known as magic states) to quantum circuits enables us to achieve universality. The resource theory of non-stablizer states aims at quantifying the usefulness of non-stabilizer states. Here, we focus on a fundamental question in this resource theory in the so called single-shot regime: Given two resource states, is there a free quantum channel that will (approximately or exactly) convert one to the other?. To provide an answer, we phrase the question as a semidefinite program with constraints on the Choi matrix of the corresponding channel. Then, we use the semidefinite version of the Farkas lemma to derive the necessary and sufficient conditions for the conversion between two arbitrary resource states via a free quantum channel. BCS appreciates financial support from Alberta Innovates, NSERC, China's 1000 Talent Plan and the Institute for Quantum Information and Matter.

  18. The Effect of Ownership Structure and Investor Protection on Firm Value: Analyst Following as Moderating Variable

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    Desi Susilawati

    2017-12-01

    Full Text Available The research related to the association between structure ownership and the firm value is a discussion about corporate governance which is still has contradictory conclusion and mixed result. It indicates open question that needs empirical evidence. The influence of concentrated ownership on firm value still brought conflict of interest so the role of analyst following can be stated as an alternative of corporate governance mechanism (Lang et al., 2004. The objectives of this research are to examine the interaction effect between concentrated ownership and analyst following, and the effect of investor protection toward firm value in five Asian companies. Asia is chosen because it has unique characteristic, in term of corporates ownership structure which is more concentrated on families and board of governance is weak (Choi, 2003. The data is consisting of 7.100 firm year observations obtained from Bloomberg and OSIRIS database for the period 2011-2013 in five Asian Countries, i.e. China, South Korea,  Malaysia, Taiwan, and Thailand. Multiple Regression analysis is used to test hypotheses. The results show that concentrated ownership is positively affects the firm value. However, there is no empirical evidence that the interaction of concentrated ownership and analyst following positively affect the firm value. As hypothesized, this research also shows that investor protection has negative impact on firm’s value.

  19. Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

    Directory of Open Access Journals (Sweden)

    Choi SJ

    2014-12-01

    Full Text Available Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction

  20. Lepton electric dipole moment and strong CP violation

    Science.gov (United States)

    Ghosh, Diptimoy; Sato, Ryosuke

    2018-02-01

    Contribution of the strong CP angle, θ bar , to the Wilson Coefficients of electron and muon electric dipole moment (EDM) operators are discussed. Previously, θ bar contribution to the electron EDM operator was calculated by Choi and Hong [1]. However, the effect of CP-violating three meson coupling was missing in [1]. We include this missing contribution for the first time in the literature, and reevaluate the Wilson coefficients of the lepton EDM operator. We obtain de = - (2.2 - 8.6) ×10-28 θ bar e-cm which is 15-70% of the result obtained in [1]. We also estimated the muon EDM as dμ = - (0.5 - 1.8) ×10-25 θ bar e-cm. Using | θ bar | ≲10-10 suggested by the neutron EDM measurements, we obtain |de | ≲ 8.6 ×10-38e-cm and |dμ | ≲ 1.8 ×10-35e-cm. The θ bar contribution to the muon EDM is much below the sensitivities of the current and near future experiments. Our result shows that the θ bar contribution to de,μ can be larger than the CKM contributions by many orders of magnitude.

  1. Lepton electric dipole moment and strong CP violation

    Directory of Open Access Journals (Sweden)

    Diptimoy Ghosh

    2018-02-01

    Full Text Available Contribution of the strong CP angle, θ¯, to the Wilson Coefficients of electron and muon electric dipole moment (EDM operators are discussed. Previously, θ¯ contribution to the electron EDM operator was calculated by Choi and Hong [1]. However, the effect of CP-violating three meson coupling was missing in [1]. We include this missing contribution for the first time in the literature, and reevaluate the Wilson coefficients of the lepton EDM operator. We obtain de=−(2.2–8.6×10−28θ¯e-cm which is 15–70% of the result obtained in [1]. We also estimated the muon EDM as dμ=−(0.5–1.8×10−25θ¯e-cm. Using |θ¯|≲10−10 suggested by the neutron EDM measurements, we obtain |de|≲8.6×10−38e-cm and |dμ|≲1.8×10−35e-cm. The θ¯ contribution to the muon EDM is much below the sensitivities of the current and near future experiments. Our result shows that the θ¯ contribution to de,μ can be larger than the CKM contributions by many orders of magnitude.

  2. Sources of spurious force oscillations from an immersed boundary method for moving-body problems

    Science.gov (United States)

    Lee, Jongho; Kim, Jungwoo; Choi, Haecheon; Yang, Kyung-Soo

    2011-04-01

    When a discrete-forcing immersed boundary method is applied to moving-body problems, it produces spurious force oscillations on a solid body. In the present study, we identify two sources of these force oscillations. One source is from the spatial discontinuity in the pressure across the immersed boundary when a grid point located inside a solid body becomes that of fluid with a body motion. The addition of mass source/sink together with momentum forcing proposed by Kim et al. [J. Kim, D. Kim, H. Choi, An immersed-boundary finite volume method for simulations of flow in complex geometries, Journal of Computational Physics 171 (2001) 132-150] reduces the spurious force oscillations by alleviating this pressure discontinuity. The other source is from the temporal discontinuity in the velocity at the grid points where fluid becomes solid with a body motion. The magnitude of velocity discontinuity decreases with decreasing the grid spacing near the immersed boundary. Four moving-body problems are simulated by varying the grid spacing at a fixed computational time step and at a constant CFL number, respectively. It is found that the spurious force oscillations decrease with decreasing the grid spacing and increasing the computational time step size, but they depend more on the grid spacing than on the computational time step size.

  3. Bound State Eigenvalues of the Schroedinger Eq. in two Spatial Variables.

    Science.gov (United States)

    Rawitscher, George H.; Koltracht, Israel

    2002-08-01

    An efficient spectral integral equation method (SIEM) has recently been developed for obtaining the scattering solution of a one-dimensional Schroedinger equation.(R.A. Gonzales, S.-Y. Kang, I. Koltracht and G. Rawitscher, J. of Comput. Phys. 153, 160 (1999).) The purpose of the present study is to extend this method to the case of bound-states in more than one dimension. Even though other methods have already been developed for this case, such as finite element methods, the application we have in mind is to solve the non-linear Bose-Einstein condensate case in the presence of an optical lattice. In the presence of a trapping potential alone, a B-E condensate solution has been obtained by a new iterative spectral method which solves the differential equation.(Y.-S. Choi, J. Javanainen, I. Koltracht, M. Koš)trun, P.J. McKenna and N. Savytska "A Fast Algorithm for the Solution of the Time-Independent Gross-Pitaevskii Equation," Submitted to Computational Physics. But this method becomes inadequate for the case that several potential barriers are also present. The reason that the SIEM is expected to be better suited is that it distributes the collocation points much more efficiently into partitions of variable size.

  4. Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models

    Science.gov (United States)

    Choi, Catherine H.; Schoenfeld, Brian P.; Bell, Aaron J.; Hinchey, Joseph; Rosenfelt, Cory; Gertner, Michael J.; Campbell, Sean R.; Emerson, Danielle; Hinchey, Paul; Kollaros, Maria; Ferrick, Neal J.; Chambers, Daniel B.; Langer, Steven; Sust, Steven; Malik, Aatika; Terlizzi, Allison M.; Liebelt, David A.; Ferreiro, David; Sharma, Ali; Koenigsberg, Eric; Choi, Richard J.; Louneva, Natalia; Arnold, Steven E.; Featherstone, Robert E.; Siegel, Steven J.; Zukin, R. Suzanne; McDonald, Thomas V.; Bolduc, Francois V.; Jongens, Thomas A.; McBride, Sean M. J.

    2016-01-01

    Fragile X is the most common monogenic disorder associated with intellectual disability (ID) and autism spectrum disorders (ASD). Additionally, many patients are afflicted with executive dysfunction, ADHD, seizure disorder and sleep disturbances. Fragile X is caused by loss of FMRP expression, which is encoded by the FMR1 gene. Both the fly and mouse models of fragile X are also based on having no functional protein expression of their respective FMR1 homologs. The fly model displays well defined cognitive impairments and structural brain defects and the mouse model, although having subtle behavioral defects, has robust electrophysiological phenotypes and provides a tool to do extensive biochemical analysis of select brain regions. Decreased cAMP signaling has been observed in samples from the fly and mouse models of fragile X as well as in samples derived from human patients. Indeed, we have previously demonstrated that strategies that increase cAMP signaling can rescue short term memory in the fly model and restore DHPG induced mGluR mediated long term depression (LTD) in the hippocampus to proper levels in the mouse model (McBride et al., 2005; Choi et al., 2011, 2015). Here, we demonstrate that the same three strategies used previously with the potential to be used clinically, lithium treatment, PDE-4 inhibitor treatment or mGluR antagonist treatment can rescue long term memory in the fly model and alter the cAMP signaling pathway in the hippocampus of the mouse model. PMID:27445731

  5. Oral immunization with rotavirus VP7 expressed in transgenic potatoes induced high titers of mucosal neutralizing IgA

    International Nuclear Information System (INIS)

    Wu Yuzhang; Li Jintao; Mou Zhirong; Fei Lei; Ni Bing; Geng Miao; Jia Zhengcai; Zhou Wei; Zou Liyun; Tang Yan

    2003-01-01

    Rotaviruses (RV) are a common cause of severe diarrhea in young children, resulting in nearly one million deaths worldwide annually. Rotavirus VP7 was the rotavirus neutralizing protein. Previous study reported that VP7 DNA vaccine can induce high levels of IgG in mice but cannot protect mice against challenge (Choi, A.H., Basu, M., Rae, M.N., McNeal, M.M., Ward, R.L., 1998. Virology 250, 230-240). We found that rotavirus VP7 could maintain its neutralizing immunity when it was transformed into the potato genome. Mice immunized with the transformed tubers successfully elicited serum IgG and mucosal IgA specific for VP7. The mucosal IgA titer was as high as 1000, while serum IgG titer was only 600. Neutralizing assays indicated that IgA could neutralize rotavirus. These results indicate the potential usefulness of plants for production and delivery of edible rotavirus vaccines

  6. PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

    Science.gov (United States)

    Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

    2010-04-01

    . The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

  7. Operational validation of a multi-period and multi-criteria model conditioning approach for the prediction of rainfall-runoff processes in small forest catchments

    Science.gov (United States)

    Choi, H.; Kim, S.

    2012-12-01

    Most of hydrologic models have generally been used to describe and represent the spatio-temporal variability of hydrological processes in the watershed scale. Though it is an obvious fact that hydrological responses have the time varying nature, optimal values of model parameters were normally considered as time invariants or constants in most cases. The recent paper of Choi and Beven (2007) presents a multi-period and multi-criteria model conditioning approach. The approach is based on the equifinality thesis within the Generalised Likelihood Uncertainty Estimation (GLUE) framework. In their application, the behavioural TOPMODEL parameter sets are determined by several performance measures for global (annual) and short (30-days) periods, clustered using a Fuzzy C-means algorithm, into 15 types representing different hydrological conditions. Their study shows a good performance on the calibration of a rainfall-runoff model in a forest catchment, and also gives strong indications that it is uncommon to find model realizations that were behavioural over all multi-periods and all performance measures, and multi-period model conditioning approach may become new effective tool for predictions of hydrological processes in ungauged catchments. This study is a follow-up study on the Choi and Beven's (2007) model conditioning approach to test how the approach is effective for the prediction of rainfall-runoff responses in ungauged catchments. To achieve this purpose, 6 small forest catchments are selected among the several hydrological experimental catchments operated by Korea Forest Research Institute. In each catchment, long-term hydrological time series data varying from 10 to 30 years were available. The areas of the selected catchments range from 13.6 to 37.8 ha, and all areas are covered by coniferous or broad-leaves forests. The selected catchments locate in the southern coastal area to the northern part of South Korea. The bed rocks are Granite gneiss, Granite or

  8. Preservação do inóculo de Plasmodiophora brassicae utilizando o método de congelamento Preservation of Plasmodiophora brassicae inoculum using the freezing method

    Directory of Open Access Journals (Sweden)

    Juliana Cristina Sodário Cruz

    2009-02-01

    Full Text Available A preservação das estruturas de resistência de Plasmodiophora brassicae, em condições laboratoriais, é dificultada pelo fato de se tratar de um parasita obrigatório. O método de congelamento, utilizando freezer, comum foi testado com o objetivo de viabilizar a sobrevivência e a preservação de suas características infectivas. Raízes de diferentes brássicas, naturalmente infectadas por P. brassicae, contendo sintomas típicos de hérnia, de uma mesma propriedade localizada no município de Pardinho, Estado de São Paulo, foram coletadas em diferentes épocas e imediatamente congeladas, em freezer, a aproximadamente -20ºC. Os tratamentos foram divididos da seguinte maneira: T1: hérnias congeladas por 389 dias (rúcula; T2: hérnias congeladas por 242 dias (brócolis; T3: hérnias congeladas por 21 dias (couve chinesa e T4: testemunha (sem inóculo. Os testes de patogenicidade, após diferentes períodos de armazenamento, foram realizados em condições de casa de vegetação (25±2ºC. Cada planta de uma variedade suscetível de couve-chinesa (Pak choi foi inoculada com 2mL da suspensão de esporos de cada tratamento, na concentração de 10(7 esporos.mL-1. Cada tratamento contou com seis repetições distribuídas em blocos ao acaso. Passadas cinco semanas após a inoculação, as raízes das plantas foram lavadas e avaliadas. Houve diferença significativa entre os tratamentos. Os materiais congelados, entre 21 a 242 dias preservaram suas características infectivas, mostrando que o método de congelamento em freezer, nesse período, pode ser uma boa opção para a preservação das estruturas de resistência deste patógeno.The preservation of Plasmodiophora brassicae resistance structures under laboratory conditions is difficult since this is an obligate parasite. The freezing method using an ordinary household freezer was tested to ensure the pathogen's survival and the preservation of its infective traits. Roots of different

  9. Prediction of emergence agitation using withdrawal reaction following rocuronium injection in preschool-aged patients undergoing inguinal herniorrhaphy: a preliminary exploratory observational trial

    Directory of Open Access Journals (Sweden)

    Kim DH

    2018-01-01

    Full Text Available Dae Hee Kim,1 Go Un Roh,2 Young Bok Lee,3 Chang Ik Choi,3 Jae Moon Lee,3 Yun Jeong Chae1 1Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon, 2Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 3Department of Anesthesiology and Pain Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea Purpose: The development of emergence agitation (EA is associated with several factors including age, preoperative anxiety, postoperative pain, anesthesia method, and surgery type. No studies have investigated whether the withdrawal reaction following rocuronium injection can predict the occurrence of EA. Therefore, we investigated this relationship in preschool-aged children undergoing inguinal herniorrhaphy, and which grade of withdrawal reaction is appropriate for identifying patients at risk of experiencing EA. Methods: A total of 40 patients were enrolled in this study. During anesthesia induction, the withdrawal reaction after loss of consciousness following rocuronium injection was assessed using a 4-point scale. After surgery, EA was assessed using the Watcha scale. Results: There was a correlation between withdrawal reaction and EA on admission to the postanesthesia care unit (PACU. Patients with a severe withdrawal reaction (grade 3 showed a significantly higher incidence of severe EA requiring medication on admission to the PACU. Conclusion: The findings of this preliminary exploratory observational study suggest that it is possible for withdrawal movement following rocuronium injection during anesthesia induction to reflect pain sensitivity of pediatric patients, which in turn may be useful in identifying those at risk of severe EA on admission to the PACU among preschool children undergoing inguinal herniorrhaphy. Further studies with a larger sample size are required to validate these findings. The exact correlation between pain

  10. Design and application of chitosan microspheres as oral and nasal vaccine carriers: an updated review

    Directory of Open Access Journals (Sweden)

    Islam MA

    2012-12-01

    Full Text Available Mohammad Ariful Islam,1–3,* Jannatul Firdous,1–3,* Yun-Jaie Choi,1 Cheol-Heui Yun,1–4 Chong-Su Cho1,21Department of Agricultural Biotechnology, 2Research Institute for Agriculture and Life Sciences, 3Center for Food and Bioconvergence, 4World Class University Biomodulation Program, Seoul National University, Seoul, South Korea*These authors contributed equally to this workAbstract: Chitosan, a natural biodegradable polymer, is of great interest in biomedical research due to its excellent properties including bioavailability, nontoxicity, high charge density, and mucoadhesivity, which creates immense potential for various pharmaceutical applications. It has gelling properties when it interacts with counterions such as sulfates or polyphosphates and when it crosslinks with glutaraldehyde. This characteristic facilitates its usefulness in the coating or entrapment of biochemicals, drugs, antigenic molecules as a vaccine candidate, and microorganisms. Therefore, chitosan together with the advance of nanotechnology can be effectively applied as a carrier system for vaccine delivery. In fact, chitosan microspheres have been studied as a promising carrier system for mucosal vaccination, especially via the oral and nasal route to induce enhanced immune responses. Moreover, the thiolated form of chitosan is of considerable interest due to its improved mucoadhesivity, permeability, stability, and controlled/extended release profile. This review describes the various methods used to design and synthesize chitosan microspheres and recent updates on their potential applications for oral and nasal delivery of vaccines. The potential use of thiolated chitosan microspheres as next-generation mucosal vaccine carriers is also discussed.Keywords: chitosan microspheres, oral, nasal, vaccine delivery, mucosal and systemic immune responses

  11. Clinical Feasibility of Continuously Monitored Data for Heart Rate, Physical Activity, and Sleeping by Wearable Activity Trackers in Patients with Thyrotoxicosis: Protocol for a Prospective Longitudinal Observational Study.

    Science.gov (United States)

    Lee, Jie-Eun; Lee, Dong Hwa; Oh, Tae Jung; Kim, Kyoung Min; Choi, Sung Hee; Lim, Soo; Park, Young Joo; Park, Do Joon; Jang, Hak Chul; Moon, Jae Hoon

    2018-02-21

    Thyrotoxicosis is a common disease caused by an excess of thyroid hormones. The prevalence of thyrotoxicosis about 2% and 70-90% of thyrotoxicosis cases are caused by Graves' disease, an autoimmune disease, which has a high recurrence rate when treated with antithyroid drugs such as methimazole or propylthiouracil. The clinical symptoms and signs of thyrotoxicosis include palpitation, weight loss, restlessness, and difficulty sleeping. Although these clinical changes in thyrotoxicosis can be detected by currently available wearable activity trackers, there have been few trials of the clinical application of wearable devices in patients with thyrotoxicosis. The aim of this study is to investigate the clinical applicability of wearable device-generated data to the management of thyrotoxicosis. We are analyzing continuously monitored data for heart rate, physical activity, and sleep in patients with thyrotoxicosis during their clinical course after treatment. Thirty thyrotoxic patients and 10 control subjects were enrolled in this study at Seoul National University Bundang Hospital. Heart rate, physical activity, and sleep are being monitored using a Fitbit Charge HR or Fitbit Charge 2. Clinical data including anthropometric measures, thyroid function test, and hyperthyroidism symptom scale are recorded. Study enrollment began in December 2016, and the intervention and follow-up phases are ongoing. The results of the data analysis are expected to be available by September 2017. This study will provide a foundational feasibility trial of the clinical applications of biosignal measurements to the differential diagnosis, prediction of clinical course, early detection of recurrence, and treatment in patients with thyrotoxicosis. ClinicalTrials.gov NCT03009357; https://clinicaltrials.gov/ct2/show/NCT03009357 (Archived by WebCite at http://www.webcitation.org/6wh4MWPm2). ©Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do

  12. Visceral fat area predicts survival in patients with advanced hepatocellular carcinoma treated with tyrosine kinase inhibitors.

    Science.gov (United States)

    Nault, Jean-Charles; Pigneur, Frédéric; Nelson, Anaïs Charles; Costentin, Charlotte; Tselikas, Lambros; Katsahian, Sandrine; Diao, Guoqing; Laurent, Alexis; Mallat, Ariane; Duvoux, Christophe; Luciani, Alain; Decaens, Thomas

    2015-10-01

    Anthropometric measurements have been linked to resistance to anti-angiogenic treatment and survival. Patients with advanced hepatocellular carcinoma treated with sorafenib or brivanib in 2008-2011 were included in this retrospective study. Anthropometric measurements were assessed using computed tomography and were correlated with drug toxicity, radiological response, and overall survival. 52 patients were included, Barcelona Clinic Liver Classification B (38%) and C (62%), with a mean value of α-fetoprotein of 29,554±85,654 ng/mL, with a median overall survival of 10.5 months. Sarcopenia was associated with a greater rate of hand-foot syndrome (P=0.049). Modified Response Evaluation Criteria In Solid Tumours (mRECIST) and Choi criteria were significantly associated with survival, but RECIST criteria were not. An absence of hand-foot syndrome and high-visceral fat area were associated with progressive disease as assessed by RECIST and mRECIST criteria. In multivariate analyses, high visceral fat area (HR=3.6; P=0.002), low lean body mass (HR=2.4; P=0.015), and presence of hand-foot syndrome (HR=1.8; P=0.004) were significantly associated with overall survival. In time-dependent multivariate analyses; only high visceral fat area was associated with survival. Visceral fat area is associated with survival and seems to be a predictive marker for primary resistance to tyrosine kinase inhibitors in patients with advanced hepatocellular carcinoma. Copyright © 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  13. Subionospheric VLF/LF radio waves propagation characteristics before, during and after the Sofia, Bulgaria Mw=5.6 earthquake occurred on 22 May 2012

    Science.gov (United States)

    Moldovan, Iren Adelina; Emilian Toader, Victorin; Nenovski, Petko; Biagi, Pier Francesco; Maggipinto, Tommaso; Septimiu Moldovan, Adrian; Ionescu, Constantin

    2013-04-01

    In 2009, INFREP, a network of VLF (20-60 kHz) and LF (150-300 kHz) radio receivers, was put into operation in Europe having as principal goal, the study of disturbances produced by the earthquakes on the propagation properties of these signals. On May 22nd, 2012 an earthquake with Mw=567 occurred in Bulgaria, near Sofia, inside the "sensitive" area of the INFREP VLF/LF electromagnetic network. The data collected on different frequencies, during April-May 2012 were studied using different methods of analysis: daily correlation methods, spectral approaches and terminator time techniques, in order to find out possible connections between the seismic activity and the subionospheric propagation properties of radio waves. The studies were performed with the help of a specially designed LabVIEW application, which accesses the VLF/LF receiver through internet. This program opens the receiver's web-page and automatically retrieves the list of data files to synchronize the user-side data with the receiver's data. Missing zipped files are also automatically downloaded. The application performs primary, statistical correlation and spectral analysis, appends daily files into monthly and annual files and performs 3D colour-coded maps with graphic representations of VLF and LF signals' intensities versus the minute-of-the-day and the day-of-the-month, facilitating a near real-time observation of VLF and LF electromagnetic waves' propagation. Another feature of the software is the correlation of the daily recorded files for the studied frequencies by overlaying the 24 hours radio activity and taking into account the sunrise and sunset. Data are individually processed (spectral power, correlations, differentiation, filtered using bandpass, lowpass, highpass). JTFA spectrograms (Cone-Shaped Distribution CSD, Gabor, Wavelet, short-time Fourier transform STFT, Wigner-Ville Distribution WVD, Choi-Williams Distribution CWD) are used, too.

  14. Anionic clay as the drug delivery vehicle: tumor targeting function of layered double hydroxide-methotrexate nanohybrid in C33A orthotopic cervical cancer model

    Directory of Open Access Journals (Sweden)

    Choi G

    2016-01-01

    Full Text Available Goeun Choi,1 Huiyan Piao,1 Zeid A Alothman,2 Ajayan Vinu,3 Chae-Ok Yun,4 Jin-Ho Choy1 1Center for Intelligent Nano-Bio Materials, Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea; 2Advanced Materials Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia; 3Future Industries Institute, University of South Australia, Mawson Lakes, SA, Australia; 4Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea Abstract: Methotrexate (MTX, an anticancer agent, was successfully intercalated into the anionic clay, layered double hydroxides to form a new nanohybrid drug. The coprecipitation and subsequent hydrothermal method were used to prepare chemically, structurally, and morphologically well-defined two-dimensional drug-clay nanohybrid. The resulting two-dimensional drug-clay nanohybrid showed excellent colloidal stability not only in deionized water but also in an electrolyte solution of Dulbecco’s Modified Eagle’s Medium with 10% fetal bovine serum, in which the average particle size in colloid and the polydispersity index were determined to be around 100 and 0.250 nm, respectively. The targeting property of the nanohybrid drug was confirmed by evaluating the tumor-to-blood and tumor-to-liver ratios of the MTX with anionic clay carrier, and these ratios were compared to those of free MTX in the C33A orthotopic cervical cancer model. The biodistribution studies indicated that the mice treated with the former showed 3.5-fold higher tumor-to-liver ratio and fivefold higher tumor-to-blood ratio of MTX than those treated with the latter at 30 minutes postinjection. Keywords: anionic clay, biodistribution, cervical cancer, colloidal stability, layered double hydroxide, methotrexate 

  15. High coronary calcium score and post-procedural CK-MB are noninvasive predictors of coronary stent restenosis

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    Lee JB

    2017-02-01

    Full Text Available Jae-Beom Lee,1 Yun-Seok Choi,2 Woo-Baek Chung,2 Ami Kwon,2 Chul-Soo Park,2 Man-Young Lee2 1Anyang Sam Hospital, 2Division of Cardiology, Department of Internal Medicine, Youido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Purpose: High coronary calcium score (CCS and post-procedural cardiac enzyme may be related with poor outcomes in patients with coronary stent implantation. Methods: A total of 1,072 patients (63.2% male, mean age: 61.7±10.3 years who underwent coronary multi-detect computed tomography at index procedure and follow-up coronary angiography (CAG after drug-eluting stent (DES were divided into two groups: those with and without target lesion revascularization (TLR; >50% reduction in luminal stent diameter or angina symptoms on follow-up CAG. The CCSs for predicting stent revascularization were elucidated. Results: There were no significant differences between the two groups with regard to risk factors. The initial CCS was significantly higher in the TLR group (1,102.4±743.7 vs 345.8±51.05, P=0.04. After adjustment of significant factors for TLR, only CCS and post-procedural creatine kinase MB form (CK-MB elevation were significant predictors of coronary artery TLR. Receiver operation curve revealed that >800 in CCS had 69% in sensitivity and 88% in specificity about predicting the TLR. Conclusion: High CCS with post-procedural CK-MB might be the useful predictors for TLR after DES implantation. Keywords: coronary restenosis, drug-eluting stents, calcium, creatine kinase

  16. Impact of GOLD groups of chronic pulmonary obstructive disease on surgical complications

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    Kim HJ

    2016-02-01

    Full Text Available Hyung-Jun Kim,1,2 Jinwoo Lee,1,2 Young Sik Park,1,2 Chang-Hoon Lee,1,2 Sang-Min Lee,1,2 Jae-Joon Yim,1,2 Chul-Gyu Yoo,1,2 Young Whan Kim,1,2 Sung Koo Han,1,2 Sun Mi Choi1,2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Purpose: Chronic obstructive pulmonary disease (COPD is associated with increased postoperative complications. Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD classified COPD patients into four groups based on spirometry results and the severity of symptoms. The objective of this study was to evaluate the impact of GOLD groups on postoperative complications. Patients and methods: We reviewed the medical records of COPD patients who underwent preoperative spirometry between April and August 2013 at a tertiary hospital in Korea. We divided the patients into GOLD groups according to the results of spirometry and self-administered questionnaires that assessed the symptom severity and exacerbation history. GOLD groups, demographic characteristics, and operative conditions were analyzed. Results: Among a total of 405 COPD patients, 70 (17.3% patients experienced various postoperative complications, including infection, wound, or pulmonary complications. Thoracic surgery, upper abdominal surgery, general anesthesia, large estimated blood loss during surgery, and longer anesthesia time were significant risk factors for postoperative complications. Patients in high-risk group (GOLD groups C or D had an increased risk of postoperative complications compared to those in low-risk group (GOLD groups A or B. Conclusion: COPD patients in GOLD groups representing a high exacerbation risk have an increased risk of postoperative complications compared to those with low risk. Keywords: chronic obstructive pulmonary

  17. Primary central nervous system diffuse large B-cell lymphoma shows an activated B-cell-like phenotype with co-expression of C-MYC, BCL-2, and BCL-6.

    Science.gov (United States)

    Li, Xiaomei; Huang, Ying; Bi, Chengfeng; Yuan, Ji; He, Hong; Zhang, Hong; Yu, QiuBo; Fu, Kai; Li, Dan

    2017-06-01

    Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, whose main prognostic factor is closely related to germinal center B-cell-like subtype (GCB- DLBCL) or activated B-cell-like type (non-GCB-DLBCL). The most common type of primary central nervous system lymphoma is diffuse large B-cell type with poor prognosis and the reason is unclear. This study aims to stratify primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) according to the cell-of-origin (COO) and to investigate the multiple proteins expression of C-MYC, BCL-6, BCL-2, TP53, further to elucidate the reason why primary central nervous system diffuse large B-cell lymphoma possesses a poor clinical outcome as well. Nineteen cases of primary central nervous system DLBCL were stratified according to immunostaining algorithms of Hans, Choi and Meyer (Tally) and we investigated the multiple proteins expression of C-MYC, BCL-6, BCL-2, TP53. The Epstein-Barr virus and Borna disease virus infection were also detected. Among nineteen cases, most (15-17 cases) were assigned to the activated B-cell-like subtype, highly expression of C-MYC (15 cases, 78.9%), BCL-2 (10 cases, 52.6%), BCL-6 (15 cases, 78.9%). Unfortunately, two cases were positive for PD-L1 while PD-L2 was not expressed in any case. Two cases infected with BDV but no one infected with EBV. In conclusion, most primary central nervous system DLBCLs show an activated B-cell-like subtype characteristic and have multiple expressions of C-MYC, BCL-2, BCL-6 protein, these features might be significant factor to predict the outcome and guide treatment of PCNS-DLBCLs. Copyright © 2017 Elsevier GmbH. All rights reserved.

  18. Changes in carbon intensity in China's industrial sector: Decomposition and attribution analysis

    International Nuclear Information System (INIS)

    Liu, Nan; Ma, Zujun; Kang, Jidong

    2015-01-01

    The industrial sector accounts for 70% of the total energy-related CO_2 emissions in China. To gain a better understanding of the changes in carbon intensity in China's industrial sector, this study first utilized logarithmic mean Divisia index (LMDI) decomposition analysis to disentangle the carbon intensity into three influencing factors, including the emission coefficient effect, the energy intensity effect, and the structure effect. Then, the analysis was furthered to explore the contributions of individual industrial sub-sectors to each factor by using an extension of the decomposition method proposed in Choi and Ang (2012). The results indicate that from 1996 to 2012, the energy intensity effect was the dominant factor in reducing carbon intensity, of which chemicals, iron and steel, metal and machinery, and cement and ceramics were the most representative sub-sectors. The structure effect did not show a strong impact on carbon intensity. The emission coefficient effect gradually increased the carbon intensity, mainly due to the expansion of electricity consumption, particularly in the metal and machinery and chemicals sub-sectors. The findings suggest that differentiated policies and measures should be considered for various industrial sub-sectors to maximize the energy efficiency potential. Moreover, readjusting the industrial structure and promoting clean and renewable energy is also urgently required to further reduce carbon intensity in China's industrial sector. - Highlights: • The study analyzed the changes in carbon intensity in China's industrial sector. • An extension of the Divisia index decomposition methodology was utilized. • Energy efficiency improvement was the dominant factor reducing carbon intensity. • The sub-sector contributions to the energy efficiency improvement varied markedly. • Emission coefficient growth can be mainly due to the expansion of electricity.

  19. How social interactions affect emotional memory accuracy: Evidence from collaborative retrieval and social contagion paradigms.

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    Kensinger, Elizabeth A; Choi, Hae-Yoon; Murray, Brendan D; Rajaram, Suparna

    2016-07-01

    In daily life, emotional events are often discussed with others. The influence of these social interactions on the veracity of emotional memories has rarely been investigated. The authors (Choi, Kensinger, & Rajaram Memory and Cognition, 41, 403-415, 2013) previously demonstrated that when the categorical relatedness of information is controlled, emotional items are more accurately remembered than neutral items. The present study examined whether emotion would continue to improve the accuracy of memory when individuals discussed the emotional and neutral events with others. Two different paradigms involving social influences were used to investigate this question and compare evidence. In both paradigms, participants studied stimuli that were grouped into conceptual categories of positive (e.g., celebration), negative (e.g., funeral), or neutral (e.g., astronomy) valence. After a 48-hour delay, recognition memory was tested for studied items and categorically related lures. In the first paradigm, recognition accuracy was compared when memory was tested individually or in a collaborative triad. In the second paradigm, recognition accuracy was compared when a prior retrieval session had occurred individually or with a confederate who supplied categorically related lures. In both of these paradigms, emotional stimuli were remembered more accurately than were neutral stimuli, and this pattern was preserved when social interaction occurred. In fact, in the first paradigm, there was a trend for collaboration to increase the beneficial effect of emotion on memory accuracy, and in the second paradigm, emotional lures were significantly less susceptible to the "social contagion" effect. Together, these results demonstrate that emotional memories can be more accurate than nonemotional ones even when events are discussed with others (Experiment 1) and even when that discussion introduces misinformation (Experiment 2).

  20. Structural domain walls in polar hexagonal manganites

    Science.gov (United States)

    Kumagai, Yu

    2014-03-01

    The domain structure in the multiferroic hexagonal manganites is currently intensely investigated, motivated by the observation of intriguing sixfold topological defects at their meeting points [Choi, T. et al,. Nature Mater. 9, 253 (2010).] and nanoscale electrical conductivity at the domain walls [Wu, W. et al., Phys. Rev. Lett. 108, 077203 (2012).; Meier, D. et al., Nature Mater. 11, 284 (2012).], as well as reports of coupling between ferroelectricity, magnetism and structural antiphase domains [Geng, Y. et al., Nano Lett. 12, 6055 (2012).]. The detailed structure of the domain walls, as well as the origin of such couplings, however, was previously not fully understood. In the present study, we have used first-principles density functional theory to calculate the structure and properties of the low-energy structural domain walls in the hexagonal manganites [Kumagai, Y. and Spaldin, N. A., Nature Commun. 4, 1540 (2013).]. We find that the lowest energy domain walls are atomically sharp, with {210}orientation, explaining the orientation of recently observed stripe domains and suggesting their topological protection [Chae, S. C. et al., Phys. Rev. Lett. 108, 167603 (2012).]. We also explain why ferroelectric domain walls are always simultaneously antiphase walls, propose a mechanism for ferroelectric switching through domain-wall motion, and suggest an atomistic structure for the cores of the sixfold topological defects. This work was supported by ETH Zurich, the European Research Council FP7 Advanced Grants program me (grant number 291151), the JSPS Postdoctoral Fellowships for Research Abroad, and the MEXT Elements Strategy Initiative to Form Core Research Center TIES.

  1. Assessing the response to targeted therapies in renal cell carcinoma: technical insights and practical considerations.

    Science.gov (United States)

    Bex, Axel; Fournier, Laure; Lassau, Nathalie; Mulders, Peter; Nathan, Paul; Oyen, Wim J G; Powles, Thomas

    2014-04-01

    The introduction of targeted agents for the treatment of renal cell carcinoma (RCC) has resulted in new challenges for assessing response to therapy, and conventional response criteria using computed tomography (CT) are limited. It is widely recognised that targeted therapies may lead to significant necrosis without significant reduction in tumour size. In addition, the vascular effects of antiangiogenic therapy may occur long before there is any reduction in tumour size. To perform a systematic review of conventional and novel imaging methods for the assessment of response to targeted agents in RCC and to discuss their use from a clinical perspective. Relevant databases covering the period January 2006 to April 2013 were searched for studies reporting on the use of anatomic and functional imaging techniques to predict response to targeted therapy in RCC. Inclusion criteria were randomised trials, nonrandomised controlled studies, retrospective case series, and cohort studies. Reviews, animal and preclinical studies, case reports, and commentaries were excluded. A narrative synthesis of the evidence is presented. A total of 331 abstracts and 76 full-text articles were assessed; 34 studies met the inclusion criteria. Current methods of response assessment in RCC include anatomic methods--based on various criteria including Choi, size and attenuation CT, and morphology, attenuation, size, and structure--and functional techniques including dynamic contrast-enhanced (DCE) CT, DCE-magnetic resonance imaging, DCE-ultrasonography, positron emission tomography, and approaches utilising radiolabelled monoclonal antibodies. Functional imaging techniques are promising surrogate biomarkers of response in RCC and may be more appropriate than anatomic CT-based methods. By enabling quantification of tumour vascularisation, functional techniques can directly and rapidly detect the biologic effects of antiangiogenic therapies compared with the indirect detection of belated effects

  2. Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

    Directory of Open Access Journals (Sweden)

    Yeom DW

    2017-05-01

    Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

  3. A new model to estimate prognosis in patients with hepatocellular carcinoma after Yttrium-90 radioembolization.

    Directory of Open Access Journals (Sweden)

    Zhihong Weng

    Full Text Available AIMS: The current prognostic model to estimate the survival in hepatocellular carcinoma (HCC patients treated with transarterial hepatic selective internal radiotherapy (SIRT is not fully characterized. The aim of this study was to establish a new scoring model including assessment of both tumor responses and therapy-induced systemic changes in HCC patients to predict survival at an early time point post-SIRT. METHODS AND MATERIALS: Between 2008 and 2012, 149 HCC patients treated with SIRT were included into this study. CT images and biomarkers in blood tested at one month post-SIRT were analyzed and correlated with clinical outcome. Tumor responses were assessed by RECIST 1.1, mRECIST, and Choi criteria. Kaplan-Meier methods were used to estimate survival curves. Cox regression was used in uni- and multivariable survival analyses and in the establishment of a prognostic model. RESULTS: A multivariate proportional hazards model was created based on the tumor response, the number of tumor nodules, the score of the model for end stage liver disease (MELD, and the serum C-reactive protein levels which were independent predictors of survival in HCC patients at one month post-SIRT. This prognostic model accurately differentiated the outcome of patients with different risk scores in this cohort (P<0.001. The model also had the ability to assign a predicted survival probability for individual patients. CONCLUSIONS: A new model to predict survival of HCC patients mainly based on tumor responses and therapy-induced systemic changes provides reliable prognosis and accurately discriminates the survival at an early time point after SIRT in these patients.

  4. Cell-penetrating superoxide dismutase attenuates oxidative stress-induced senescence by regulating the p53-p21Cip1 pathway and restores osteoblastic differentiation in human dental pulp stem cells

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    Park YJ

    2012-09-01

    Full Text Available Yoon Jung Choi,1,* Jue Yeon Lee,2,* Chong Pyoung Chung,2 Yoon Jeong Park,1,21Craniomaxillofacial Reconstructive Sciences, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; 2Research Institute, Nano Intelligent Biomedical Engineering, Seoul, Republic of Korea*These authors contributed equally to this workBackground: Human dental pulp stem cells (DPSCs have potential applications in tissue regeneration because of their convenient cell harvesting procedures and multipotent capacity. However, the tissue regenerative potential of DPSCs is known to be negatively regulated by aging in long-term culture and under oxidative stress. With an aim of reducing cellular senescence and oxidative stress in DPSCs, an intracellular delivery system for superoxide dismutase 1 (SOD1 was developed. We conjugated SOD1 with a cell-penetrating peptide known as low-molecular weight protamine (LMWP, and investigated the effect of LMWP-SOD1 conjugates on hydrogen peroxide-induced cellular senescence and osteoblastic differentiation.Results: LMWP-SOD1 significantly attenuated enlarged and flattened cell morphology and increased senescence-associated β-galactosidase activity. Under the same conditions, LMWP-SOD1 abolished activation of the cell cycle regulator proteins, p53 and p21Cip1, induced by hydrogen peroxide. In addition, LMWP-SOD1 reversed the inhibition of osteoblastic differentiation and downregulation of osteogenic gene markers induced by hydrogen peroxide. However, LMWP-SOD1 could not reverse the decrease in odontogenesis caused by hydrogen peroxide.Conclusion: Overall, cell-penetrating LMWP-SOD1 conjugates are effective for attenuation of cellular senescence and reversal of osteoblastic differentiation of DPSCs caused by oxidative stress inhibition. This result suggests potential application in the field of antiaging and tissue engineering to overcome the limitations of senescent stem cells.Keywords: superoxide

  5. Resident wellness: institutional trends over 10 years since 2003

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    Choi D

    2017-07-01

    Full Text Available Dongseok Choi,1,2 Andrea Cedfeldt,3,4 Christine Flores,5 Kimberly Irish,3 Patrick Brunett,3,6 Donald Girard3,4 1OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA; 2School of Dentistry, Kyung Hee University, Seoul, Korea; 3Division of Graduate Medical Education, 4Department of Medicine, 5Division of Continuing Professional Development, 6Department of Emergency Medicine, Oregon Health & Science University, Portland, OR, USA Background: The surveys in this study were carried out at the Graduate Medical Education Division at Oregon Health & Science University (OHSU. OHSU implemented two significant wellness initiatives: a wellness program in 2004, and a policy allowing 4 half-days off each academic year to pursue personal or family health care needs in 2010. This study provides a secondary data analysis of five cross-sectional surveys of career satisfaction of resident and fellow trainees. Methods: All trainees were surveyed five times over a 10-year period using anonymous, cross-sectional web-based survey instruments. Surveys included questions about career satisfaction, perceived stress, sleep hours, burnout, and related factors.Results: This represents 10 years of accumulated responses from over 2,200 residents with results showing continual improvement in their career satisfaction. Response rates ranged from 56% to 72%. During the study period, there was a significant positive change in overall resident career satisfaction, with little change in factors traditionally considered to be predictive of overall career satisfaction such as sleep hours or perceived stress level. In addition, our data support that availability of time for personal tasks could positively impact the overall training experience.Conclusion: We postulate that the improvements in satisfaction relate to two major institutional innovations designed to promote resident wellness. Keywords: satisfaction, burnout, graduate medical education

  6. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

    Directory of Open Access Journals (Sweden)

    Kim SR

    2015-08-01

    Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

  7. 3-aminopropyl functionalized magnesium phyllosilicate as an organoclay based drug carrier for improving the bioavailability of flurbiprofen

    Directory of Open Access Journals (Sweden)

    Yang L

    2013-10-01

    Full Text Available Liang Yang,1 Soo-Kyung Choi,2 Hyun-Jae Shin,2 Hyo-Kyung Han1 1College of Pharmacy, Dongguk University-Seoul, Siksa-dong, Ilsan-Donggu, Goyang, Gyunggi-do, Korea; 2Department of Chemical and Biochemical Engineering, Chosun University, Gwangju, Korea Abstract: This study aimed to develop an oral delivery system using clay-based organic–inorganic hybrid materials to improve the bioavailability of the drug, flurbiprofen, which is poorly soluble in water. 3-aminopropyl functionalized magnesium phyllosilicate (AMP clay was synthesized by a one-pot direct sol-gel method, and then flurbiprofen (FB was incorporated into AMP clay (FB-AMP at different drug/clay ratios. The structural characteristics of AMP and FB-AMP formulation were confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. Among tested formulations, FB-AMP(3, dramatically increased the dissolution of FB and achieved rapid and complete drug release within 2 hours. More than 60% of FB was released from FB-AMP(3 after 30 minutes; the drug was completely dissolved in the water within 2 hours. Under the acidic condition (pH 1.2, FB-AMP(3 also increased the dissolution of FB by up to 47.1% within 1 hour, which was three-fold higher than that of untreated FB. Furthermore, following an oral administration of FB-AMP(3 to Sprague-Dawley rats, the peak plasma concentration and area under the plasma concentration-time curve of FB increased two-fold, and the time to reach the peak plasma concentration was shortened compared with that in the untreated FB. This result suggests that the oral drug delivery system using clay-based organic–inorganic hybrid material might be useful to improve the bioavailability of FB. Keywords: poorly water-soluble drugs, aminopropyl functionalized magnesium phyllosilicate, organic clay, oral bioavailability

  8. Bioreactor systems for tissue engineering II. Strategies for the expansion and directed differentiation of stem cells

    Energy Technology Data Exchange (ETDEWEB)

    Kasper, Cornelia [Hannover Univ. (Germany). Inst. fuer Technische Chemie; Griensven, Martijn van [Ludwig Boltzmann Institut fuer Klinische und Experimentelle Traumatologie, Wien (Austria); Poertner, Ralf (eds.) [Technische Univ. Hamburg-Harburg (Germany). Inst. Biotechnologie und Verfahrenstechnik

    2010-07-01

    Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; - Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; - Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; - Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; - Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; - Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; - Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; - Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; - Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geissler, C. Gittel, H. Juelke, W. Brehm; - Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; - Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi. (orig.)

  9. Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

    Directory of Open Access Journals (Sweden)

    Ganesan P

    2015-10-01

    Full Text Available Palanivel Ganesan,1,2 Hyun-Myung Ko,2 In-Su Kim,2 Dong-Kug Choi1,2 1Nanotechnology Research Center, Department of Applied Life Science, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea Abstract: Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD, which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1 the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2 the role of nanotechnology in reducing oxidative stress during PD; 3 nanodelivery systems; and 4 various nanophytobioactive compounds and their role in PD. Keywords: Parkinson’s disease, phytobioactive compounds, nanotechnology delivery systems, nanocurcumin

  10. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

    Directory of Open Access Journals (Sweden)

    Ganesan P

    2016-05-01

    Full Text Available Palanivel Ganesan,1,2 Dong-Kug Choi1,2 1Department of Applied Life Science, Nanotechnology Research Center, 2Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju, Republic of Korea Abstract: Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera, curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy. Keywords: nanodelivery technologies, skincare

  11. Evaluating statistical approaches to leverage large clinical datasets for uncovering therapeutic and adverse medication effects.

    Science.gov (United States)

    Choi, Leena; Carroll, Robert J; Beck, Cole; Mosley, Jonathan D; Roden, Dan M; Denny, Joshua C; Van Driest, Sara L

    2018-04-18

    Phenome-wide association studies (PheWAS) have been used to discover many genotype-phenotype relationships and have the potential to identify therapeutic and adverse drug outcomes using longitudinal data within electronic health records (EHRs). However, the statistical methods for PheWAS applied to longitudinal EHR medication data have not been established. In this study, we developed methods to address two challenges faced with reuse of EHR for this purpose: confounding by indication, and low exposure and event rates. We used Monte Carlo simulation to assess propensity score (PS) methods, focusing on two of the most commonly used methods, PS matching and PS adjustment, to address confounding by indication. We also compared two logistic regression approaches (the default of Wald vs. Firth's penalized maximum likelihood, PML) to address complete separation due to sparse data with low exposure and event rates. PS adjustment resulted in greater power than propensity score matching, while controlling Type I error at 0.05. The PML method provided reasonable p-values, even in cases with complete separation, with well controlled Type I error rates. Using PS adjustment and the PML method, we identify novel latent drug effects in pediatric patients exposed to two common antibiotic drugs, ampicillin and gentamicin. R packages PheWAS and EHR are available at https://github.com/PheWAS/PheWAS and at CRAN (https://www.r-project.org/), respectively. The R script for data processing and the main analysis is available at https://github.com/choileena/EHR. leena.choi@vanderbilt.edu. Supplementary data are available at Bioinformatics online.

  12. Would Confucius benefit from psychotherapy? The compatibility of cognitive behaviour therapy and Chinese values.

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    Hodges, Julie; Oei, Tian P S

    2007-05-01

    The purpose of the present paper is to explore the conceptual compatibility between cognitive behaviour therapy (CBT) and the common values of Chinese Culture. In order to address such a question, the distinctive processes attributed to CBT (e.g., teaching of skills, emphasis on homework, cognitive processes, present/future focus), as summarized in the meta-analysis by Blagys and Hilsenroth [(2002). Distinctive activities of cognitive-behavioral therapy: A review of the comparative psychotherapy process literature. Clinical Psychology Review, 22, 671-706], and the core values of Chinese Culture, determined through an integration of The Hofstede Project, [Hofstede, G.H. (1980). Culture's consequences: International differences in work related values. Beverly Hills: Sage]. The Chinese Value Survey [Chinese Culture Connection (1987). Chinese values and the search for culture-free dimensions of culture. Journal of Cross-Cultural Psychology, 18, 143-164]. The Schwartz Value Survey [Schwartz, S.H. (1994). Cultural dimensions of values: Towards an understanding of national differences. In Kim, U., Trandis, H.C., Katiticibasi, C., Choi, S.C., & Yoon, G. (eds.), Individualism and collectivism: Theory, method and application (pp. 85-119). Thousand Oaks, CA: Sage] were used. A strong degree of compatibility between the two was found and it is argued that rather than developing new indigenized therapies, with some structural changes to the processes of CBT, this therapy can be effective for Chinese clients. It is further proposed that Chinese clients may benefit from challenging their irrational cognitions that are bound up in their strict adherence to social norms. Future recommendations for increasing the compatibility of CBT to Chinese culture are discussed.

  13. Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease

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    Lee JH

    2016-08-01

    Full Text Available Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD, sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis

  14. Hong Kong: country profile.

    Science.gov (United States)

    Fozzard, A

    1988-09-01

    In the 1840s, the small fishing community that is now Hong Kong became a British colony and an important naval base for the Opium Wars. Now it is a leading capitalist center operating on mainland communist China. Hong Kong is scheduled to go back to China in 1997. In the agreement signed between the British government and China, Hong Kong's present lifestyle is guaranteed for at least 50 years. Textbook colonialism rules here. Foreigners hold the key jobs and earn much more than do the indigenous people. They even receive subsidized housing in this very high rent colony. As for the Hong Kong Chinese, overcrowding into 2 room apartments is the norm even though the government tries to provide more housing units. The large skyscrapers in the New Territories breed their unique social and mental health problems, such as poverty, drug abuse and frustration. Essentially all food is imported from communist China, yet agriculture in Hong Kong does exist--pig farms, duck lakes, and fields of the popular vegetable choi sum. Major industry comprise textiles and sweat shops which pay their workers (mostly illegal immigrants and children with no legal protection) wages that are 1/4 of those paid in Great Britain. Financial services, trade, and tourism may soon dominate Hong Kong's economy. Almost 4 million tourists visit Hong Kong yearly, often looking for bargains. Despite Hong Kong's active Western-like business climate, Chinese culture still abounds. Traditional incense burns in Buddhist temples. Snake soup is served in restaurants. Plus traditional medicine practiced alongside Western medicine contributes to Hong Kong having 1 of the lowest infant mortality rates in the world (9/1000) and to its high life expectancy of 76 years.

  15. Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

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    Choi SJ

    2015-04-01

    Full Text Available Soo-Jin Choi, Hee-Jeong Paek, Jin YuDepartment of Food Science and Technology, Seoul Women’s University, Seoul, Republic of KoreaAbstract: Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs that have been shown to exhibit toxicity by inducing reactive oxidative species and a proinflammatory mediator in human lung epithelial A549 cells. However, the molecular mechanism responsible for this LDH-NP-induced toxicity and the relationship between oxidative stress and inflammatory events remains unclear. In this study, we focused on intracellular signaling pathways and transcription factors induced in response to oxidative stress caused by exposure to LDH-NPs in A549 cells. Mitogen-activated protein kinase (MAPK cascades, such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase (JNK, and p38, were investigated as potential signaling mechanisms responsible for regulation of oxidative stress and cytokine release. Src family kinases (SFKs, which are known to mediate activation of MAPK, together with redox-sensitive transcription factors, including nuclear factor kappa B and nuclear factor-erythroid 2-related factor-2, were also investigated as downstream events of MAPK signaling. The results obtained suggest that LDH-NP exposure causes oxidative stress, leading to expression of antioxidant enzymes, such as catalase, glucose reductase, superoxide dismutase, and heme oxygenase-1, via a SFK-JNK and p38-nuclear factor kappa B signaling pathway. Further, activation of this signaling was also found to regulate release of inflammatory cytokines, including interleukin-6 and interleukin-8, demonstrating the inflammatory potential of LDH-NP.Keywords: layered double hydroxide, mitogen-activated protein kinases, Src family kinases, nuclear factor kappa B, oxidative stress, inflammatory cytokine

  16. Interactions of galaxies outside clusters and massive groups

    Science.gov (United States)

    Yadav, Jaswant K.; Chen, Xuelei

    2018-06-01

    We investigate the dependence of physical properties of galaxies on small- and large-scale density environment. The galaxy population consists of mainly passively evolving galaxies in comparatively low-density regions of Sloan Digital Sky Survey (SDSS). We adopt (i) local density, ρ _{20}, derived using adaptive smoothing kernel, (ii) projected distance, r_p, to the nearest neighbor galaxy and (iii) the morphology of the nearest neighbor galaxy as various definitions of environment parameters of every galaxy in our sample. In order to detect long-range interaction effects, we group galaxy interactions into four cases depending on morphology of the target and neighbor galaxies. This study builds upon an earlier study by Park and Choi (2009) by including improved definitions of target and neighbor galaxies, thus enabling us to better understand the effect of "the nearest neighbor" interaction on the galaxy. We report that the impact of interaction on galaxy properties is detectable at least up to the pair separation corresponding to the virial radius of (the neighbor) galaxies. This turns out to be mostly between 210 and 360 h^{-1}kpc for galaxies included in our study. We report that early type fraction for isolated galaxies with r_p > r_{vir,nei} is almost ignorant of the background density and has a very weak density dependence for closed pairs. Star formation activity of a galaxy is found to be crucially dependent on neighbor galaxy morphology. We find star formation activity parameters and structure parameters of galaxies to be independent of the large-scale background density. We also exhibit that changing the absolute magnitude of the neighbor galaxies does not affect significantly the star formation activity of those target galaxies whose morphology and luminosities are fixed.

  17. SARC009: Phase 2 study of dasatinib in patients with previously treated, high-grade, advanced sarcoma.

    Science.gov (United States)

    Schuetze, Scott M; Wathen, J Kyle; Lucas, David R; Choy, Edwin; Samuels, Brian L; Staddon, Arthur P; Ganjoo, Kristen N; von Mehren, Margaret; Chow, Warren A; Loeb, David M; Tawbi, Hussein A; Rushing, Daniel A; Patel, Shreyaskumar R; Thomas, Dafydd G; Chugh, Rashmi; Reinke, Denise K; Baker, Laurence H

    2016-03-15

    Dasatinib exhibited activity in preclinical models of sarcoma. The Sarcoma Alliance for Research through Collaboration (SARC) conducted a multicenter, phase 2 trial of dasatinib in patients with advanced sarcoma. Patients received dasatinib twice daily. The primary objective was to estimate the clinical benefit rate (CBR) (complete response or partial response within 6 months or stable disease duration of ≥6 months) with a target of ≥25%. Patients were enrolled into 1 of 7 different cohorts and assessed by imaging every 8 weeks using Choi criteria tumor response and a Bayesian hierarchical design. For each subtype, enrollment was stopped after a minimum of 9 patients were treated if there was a sarcoma (UPS) cohorts fully accrued and 6 of 47 and 8 of 42 evaluable patients, respectively, exhibited clinical benefit. The probability that the CBR was ≥25% in the LMS and UPS cohorts was 0.008 and 0.10, respectively. The median progression-free survival ranged from 0.9 months in patients with rhabdomyosarcoma to 2.2 months in patients with LMS. The median overall survival was 8.6 months. The most frequent adverse events were constitutional, gastrointestinal, and respiratory, and 36% of patients required dose reduction for toxicity. Serious adverse events attributed to therapy occurred in 11% of patients. Dasatinib may have activity in patients with UPS but is inactive as a single agent in the other sarcoma subtypes included herein. The Bayesian design allowed for the early termination of accrual in 5 subtypes because of lack of drug activity. © 2015 American Cancer Society.

  18. OPTIMIZACIÓN DE COMBINACIÓN CARNE DE CHAME (Dormitator latifrons Y CARNE DE RES EN PROCESAMIENTO DE SALCHICHA

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    Manuel Vicente Ganchoso Espinoza

    2012-12-01

    Full Text Available La investigación se realizó con el objetivo de obtener una salchicha mixta, utilizando como principales ingredientes carne de chame y carne de res, que cumpla con los requisitos establecidos por el Instituto Ecuatoriano de Normalización (INEN 1338:96. Se formularon tres combinaciones (p/p:kg/kg de carnes chame:res, obteniendo los tratamientos A1 (10:60, A2 (20:50, A3(30:40 y un tratamiento testigo (A4 compuesto de carne de res (0:70, la unidad experimental fue de un kilogramo. Se evaluaron parámetros bromatológicos (proteína, grasa, humedad, cenizas y pH, microbiológicos (Salmonella, Staphylococcus aureus, Enterobacteriaceae, Escherichia coli y Recuento estándar en Placas (REP para aerobios mesófilos y propiedades térmicas de la salchicha (calor específico, difusividad térmica y conductividad térmica aplicando el modelo matemático de Choi y Okos. En las características bromatológicas se encontró diferencias significativas (p<0.01 en todas las formulaciones; en los microbiológicos alcanzaron lo establecido por la norma INEN 133. El calor específico se incrementa en función de la temperatura. Se concluye que la salchicha con menor porcentaje de carne de chame (A1 presenta parámetros bromatológicos apropiados. Las propiedades térmicas variaron a diferentes temperaturas, demostrando que a mayor temperatura aumenta su calor específico, difusividad y conductividad térmica.

  19. Targeted Acoustic Data Processing for Ocean Ecological Studies

    Science.gov (United States)

    Sidorovskaia, N.; Li, K.; Tiemann, C.; Ackleh, A. S.; Tang, T.; Ioup, G. E.; Ioup, J. W.

    2015-12-01

    The Gulf of Mexico is home to many species of deep diving marine mammals. In recent years several ecological studies have collected large volumes of Passive Acoustic Monitoring (PAM) data to investigate the effects of anthropogenic activities on protected and endangered marine mammal species. To utilize these data to their fullest potential for abundance estimates and habitat preference studies, automated detection and classification algorithms are needed to extract species acoustic encounters from a continuous stream of data. The species which phonate in overlapping frequency bands represent a particular challenge. This paper analyzes the performance of a newly developed automated detector for the classification of beaked whale clicks in the Northern Gulf of Mexico. Current used beaked whale classification algorithms rely heavily on experienced human operator involvement in manually associating potential events with a particular species of beaked whales. Our detection algorithm is two-stage: the detector is triggered when the species-representative phonation band energy exceeds the baseline detection threshold. Then multiple event attributes (temporal click duration, central frequency, frequency band, frequency sweep rate, Choi-Williams distribution shape indices) are measured. An attribute vector is then used to discriminate among different species of beaked whales present in the Gulf of Mexico and Risso's dolphins which were recognized to mask the detections of beaked whales in the case of widely used energy-band detectors. The detector is applied to the PAM data collected by the Littoral Acoustic Demonstration Center to estimate abundance trends of beaked whales in the vicinity of the 2010 oil spill before and after the disaster. This algorithm will allow automated processing with minimal operator involvement for new and archival PAM data. [The research is supported by a BP/GOMRI 2015-2017 consortium grant.

  20. In search of a theoretical structure for understanding motivation in schizophrenia.

    Science.gov (United States)

    Medalia, Alice; Brekke, John

    2010-09-01

    This themed issue considers different ways to conceptualize the motivational impairment that is a core negative symptom of schizophrenia. Motivational impairment has been linked to poor functional outcome, thus it is important to understand the nature and causes of motivational impairment in order to develop better treatment strategies to enhance motivation and engage patients in the process of recovery. Motivation refers to the processes whereby goal-directed activities are instigated and sustained and can be thought of as the product of a complex interaction of physiological processes and social contextual variables. In this issue, the physiological processes of motivation are the focus of Barch and Dowd, who highlight the role of prefrontal and subcortical mesolimbic dopamine systems in incentive-based learning and the difficulties people with schizophrenia have using internal representations of relevant experiences and goals to drive the behavior that should allow them to obtain desired outcomes. The articles in this issue by Choi et al., Nakagami et al., and Silverstein, focus on social contextual or environmental variables that can shape behavior and motivation. Together, these articles highlight the impact of external cues and goal properties on the expectations and values attached to goal outcomes. Expectancy-value and Self-Determination theories provide an overarching framework to accommodate the perspectives and data provided in all these articles. In the following introduction we show how the articles in this themed issue both support the role of expectancies and value in motivation in schizophrenia and elucidate possible deficiencies in the way expectations and value get assigned.

  1. Measuring negative symptoms in patients with schizophrenia: reliability and validity of the Korean version of the Motivation and Pleasure Scale-Self-Report

    Directory of Open Access Journals (Sweden)

    Kim JS

    2016-05-01

    Full Text Available Ji-Sun Kim,1 Seon-Kyeong Jang,1 Seon-Cheol Park,2 Jung-Seo Yi,3 Joong-Kyu Park,4 Jung Suk Lee,5 Kee-Hong Choi,6 Seung-Hwan Lee1,7 1Clinical Emotion and Cognition Research Laboratory, Goyang, 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, 3Department of Psychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, 4Department of Rehabilitation Psychology, Daegu University, Daegu, 5Department of Psychiatry, National Health Insurance Service Ilsan Hospital, Goyang, 6Department of Psychology, Korea University, Seoul, 7Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea Background: The Clinical Assessment Interview for Negative Symptoms (CAINS is one of the validated interview measures of negative symptoms in psychotic disorders. The Motivation and Pleasure Scale-Self-Report (MPSR is a self-report measure that assesses the motivation and pleasure domains of negative symptoms based on the CAINS. This study evaluated the reliability and validity of a Korean version of the MPSR.Methods: A total of 139 patients with schizophrenia completed the MPSR, CAINS, Scale for the Assessment of Negative Symptoms (SANS, Brief Psychiatric Rating Scales, Calgary Depression Scale for Schizophrenia, and other measures of trait and cognitive function.Results: The 15-item MPSR showed good internal consistency. In addition, it also had a good convergent validity with the Motivation and Pleasure subscale of the CAINS and the anhedonia/avolition subscale of the SANS. The scale was not associated with psychotic symptoms, agitation/mania, and depression/anxiety, and it showed good discriminant validity. MPSR scores were significantly correlated with Behavioral Activation System total score for trait measure.Conclusion: The Korean version of the MPSR is a notable self-report method for examining the severity of negative symptoms in schizophrenia. Keywords: Korean

  2. Development and validation of the Pictorial Cognitive Screening Inventory for illiterate people with dementia

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    Park S

    2014-09-01

    Full Text Available Soowon Park,1,* Se-Eun Park,1,* Min-Ji Kim,2 Hee-Yeon Jung,1,2 Jung-Seok Choi,1,2 Kee-Hwan Park,3 Inhye Kim,1 Jun-Young Lee1,2 1Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea; 2Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Department of Psychology, The Catholic University of Korea, Bucheon, Republic of Korea *These authors contributed equally to this work Purpose: The purpose of this study was to develop and validate a tool called the Pictorial Cognitive Screening Inventory (PCSI, which consists of pictorial memory and attention tests that are not influenced by literacy level.Patients and methods: PCSI, Mini Mental State Examination (MMSE, and Clinical Dementia Rating (CDR questionnaires were administered to 80 elderly participants (20 illiterate normal, 20 illiterate with dementia, 20 literate normal, and 20 literate with dementia.Results: PCSI scores were highly correlated with those of the MMSE (r 0.51 and the CDR (r -0.71. In addition, the PCSI scores differed significantly between the normal group and the dementia group (mean difference 1.71, standard error [SE] 0.14, P<0.001, while no such difference was observed between the illiterate group and the literate group (mean difference 0.00, SE 0.24, P=0.997. Diagnostic validity of the PCSI is excellent, with a sensitivity of 90% and a specificity of 98% for screening dementia, whereas the MMSE has a sensitivity of 85% and a specificity of 60%.Conclusion: These results indicate that the PCSI is a sensitive and reliable test for screening dementia, regardless of an individual’s literacy skills. The PCSI meets the increasing needs for screening of dementia in illiterate elderly populations in developing countries. Keywords: screening, dementia, literacy, cognition 

  3. Mind the Roots: Phenotyping Below-Ground Crop Diversity and Its Influence on Final Yield

    Science.gov (United States)

    Nieters, C.; Guadagno, C. R.; Lemli, S.; Hosseini, A.; Ewers, B. E.

    2017-12-01

    Changes in global climate patterns and water regimes are having profound impacts on worldwide crop production. An ever-growing population paired with increasing temperatures and unpredictable periods of severe drought call for accurate modeling of future crop yield. Although novel approaches are being developed in high-throughput, above-ground image phenotyping, the below-ground plant system is still poorly phenotyped. Collection of plant root morphology and hydraulics are needed to inform mathematical models to reliably estimate yields of crops grown in sub-optimal conditions. We used Brassica rapa to inform our model as it is a globally cultivated crop with several functionally diverse cultivars. Specifically, we use 7 different accessions from oilseed (R500 and Yellow Sarson), leafy type (Pac choi and Chinese cabbage), a vegetable turnip, and two Wisconsin Fast Plants (Imb211 and Fast Plant self-compatible), which have shorter life cycles and potentially large differences in allocation to roots. Bi-weekly, we harvested above and below-ground biomass to compare the varieties in terms of carbon allocation throughout their life cycle. Using WinRhizo software, we analyzed root system length and surface area to compare and contrast root morphology among cultivars. Our results confirm that root structural characteristics are crucial to explain plant water use and carbon allocation. The root:shoot ratio reveals a significant (p physiological traits such as gas exchange, chlorophyll content, and chlorophyll a fluorescence. A thorough analysis of the root system will clarify carbon dynamics and hydraulics at the whole-plant level, improving final yield predictions.

  4. Increased Mortality in Relation to Insomnia and Obstructive Sleep Apnea in Korean Patients Studied with Nocturnal Polysomnography

    Science.gov (United States)

    Choi, Jae-Won; Song, Ji Soo; Lee, Yu Jin; Won, Tae-Bin; Jeong, Do-Un

    2017-01-01

    Study Objectives: To elucidate the links between the two most prevalent sleep disorders, insomnia and obstructive sleep apnea (OSA), and mortality. Methods: We studied 4,225 subjects who were referred to the Center for Sleep and Chronobiology, Seoul National University Hospital, from January 1994 to December 2008. We divided the subjects into five groups: mild OSA (5 ≤ AHI insomnia, and a no-sleep-disorder group consisting of subjects without sleep disorders. Standardized mortality ratio (SMR), hazard ratio, and the survival rates of the five groups were calculated and evaluated. Results: The SMR of all-cause mortality was significantly higher in the severe OSA group than in the general population (1.52, 95% CI 1.23–1.85, p cause mortality (HR 3.50, 95% CI 1.03–11.91, p = 0.045) and cardiovascular mortality (HR 17.16, 95% CI 2.29–128.83, p = 0.006). Cardiovascular mortality was also significantly elevated in the insomnia group (HR 8.11, 95% CI 1.03–63.58, p = 0.046). Conclusions: Severe OSA was associated with increased all-cause mortality and cardiovascular mortality compared to the no-sleep-disorder group. Insomnia was associated with increased cardiovascular mortality compared to the no-sleep-disorder group. Citation: Choi JW, Song JS, Lee YJ, Won TB, Jeong DU. Increased mortality in relation to insomnia and obstructive sleep apnea in Korean patients studied with nocturnal polysomnography. J Clin Sleep Med. 2017;13(1):49–56. PMID:27655449

  5. Changes in cerebral blood flow after cognitive behavior therapy in patients with panic disorder: a SPECT study

    Directory of Open Access Journals (Sweden)

    Seo HJ

    2014-04-01

    Full Text Available Ho-Jun Seo,1 Young Hee Choi,2 Yong-An Chung,3 Wangku Rho,1 Jeong-Ho Chae11Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Metta Institute of Cognitive Behavior Therapy, Seoul, South Korea; 3Department of Radiology, Nuclear Medicine, College of Medicine, The Catholic University of Korea, Seoul, South KoreaAim: Inconsistent results continue to be reported in studies that examine the neural correlates of cognitive behavioral therapy (CBT in patients with panic disorder. We examined the changes in regional cerebral blood flow (rCBF associated with the alleviation of anxiety by CBT in panic patients.Methods: The change in rCBF and clinical symptoms before and after CBT were assessed using single photon emission computed tomography and various clinical measures were analyzed.Results: Fourteen subjects who completed CBT showed significant improvements in symptoms on clinical measures, including the Panic and Agoraphobic Scale and the Anxiety Sensitivity Index-Revised. After CBT, increased rCBF was detected in the left postcentral gyrus (BA 43, left precentral gyrus (BA 4, and left inferior frontal gyrus (BA 9 and BA 47, whereas decreased rCBF was detected in the left pons. Correlation analysis of the association between the changes in rCBF and changes in each clinical measure did not show significant results.Conclusion: We found changes in the rCBF associated with the successful completion of CBT. The present findings may help clarify the effects of CBT on changes in brain activity in panic disorder.Keyword: single photon emission computed tomography (SPECT, anxiety, neural correlate, brain activity

  6. Measurement and Analysis of Ultra-Thin Austenitic Stainless Steel Sheet under Biaxial Tensile Loading and In-Plane Reverse Loading

    Science.gov (United States)

    Murakoso, Satoko; Kuwabara, Toshihiko

    Biaxial tensile tests of austenitic stainless steel sheet (SUS304) 0.2mm thick have been carried out using cruciform specimens. The specimens are loaded under linear stress paths in a servo-controlled biaxial tensile testing machine. Plastic orthotropy remained coaxial with the principal stresses throughout every experiment. The successive contours of plastic work in biaxial stress space changed their shapes progressively, exemplifying differential work hardening. The geometry of the entire family of the work contours and the directions of plastic strain rates have been precisely measured and compared with those calculated using conventional yield functions. Yld2000-2d [Barlat, F., Brem, J.C., Yoon, J.W., Chung, K., Dick, R.E., Lege, D.J., Pourboghrat, F., Choi, S.H. and Chu, E., International Journal of Plasticity, Vol. 19, (2003), pp. 1297-1319.] with an exponent of 6 was capable of reproducing the general trends of the work contours and the directions of plastic strain rates with good accuracy. Furthermore, in order to quantitatively evaluate the Bauschinger effect of the test material, in-plane tension/compression tests are conducted. It was found that the non-dimensional (σ /σu) - Δɛ /(σu/ E) curves measured during unloading almost fall on a single curve and are not affected by the amount of pre-strain, where σ is the current stress during unloading, σu is the stress immediately before unloading, Δɛ (< 0) is the total strain increment during unloading.

  7. Preliminary development of the Active Colonoscopy Training Model

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    Choi J

    2011-06-01

    Full Text Available JungHun Choi1, Kale Ravindra1, Randolph Robert1, David Drozek21Mechanical Engineering, Ohio University, Athens, OH, USA; 2College of Osteopathic Medicine, Ohio University, Athens, OH, USAAbstract: Formal colonoscopy training requires a significant amount of time and effort. In particular, it requires actual patients for a realistic learning experience. The quality of colonoscopy training varies, and includes didactic courses and procedures proctored by skilled surgeons. A colonoscopy training model is occasionally used as part of the training method, but the effects are minute due to both the simple and tedious training procedures. To enhance the educational effect of the colonoscopy training model, the Active Colonoscopy Training Model (ACTM has been developed. ACTM is an interactive colonoscopy training device which can create the environment of a real colonoscopy procedure as closely as possible. It comprises a configurable rubber colon, a human torso, sensors, a display, and the control part. The ACTM provides audio and visual interaction to the trainee by monitoring important factors, such as forces caused by the distal tip and the shaft of the colonoscope and the pressure to open up the lumen and the localization of the distal tip. On the computer screen, the trainee can easily monitor the status of the colonoscopy, which includes the localization of the distal tip, maximum forces, pressure inside the colon, and surgery time. The forces between the rubber colon and the constraints inside the ACTM are measured and the real time display shows the results to the trainee. The pressure sensors will check the pressure at different parts of the colon. The real-time localized distal tip gives the colonoscopy trainee easier and more confident operation without introducing an additional device in the colonoscope. With the current need for colonoscopists and physicians, the ACTM can play an essential role resolving the problems of the current

  8. Changes in CO2 emission intensities in the Mexican industry

    International Nuclear Information System (INIS)

    González, Domingo; Martínez, Manuel

    2012-01-01

    A CO 2 emission intensity analysis in the Mexican industry from 1965 to 2010 is carried out by taking into consideration four stages: 1965–1982, 1982–1994, 1994–2003, and 2004–2010. Based on the LMDI decomposition methodology, three influencing factors are analyzed: energy intensity, CO 2 coefficient, and structure in terms of their contributions of each individual attributes to the overall percent change of them as it was proposed in Choi and Ang (2011). The energy intensity effect was the driving factor behind the main decreases of CO 2 intensity, the CO 2 coefficient effect contributed to less extent to mitigate it, and the structure effect tended to increased it. It is observed that CO 2 intensity declined by 26.2% from 1965 to 2003, but it increased by 10.1% from 2004 to 2010. In addition, the move of Mexico from an economic model based on import-substitution to an export-oriented economy brought more importance to the Mexican industry intended to export, thus maintaining high levels of activity of industries such as cement, iron and steel, chemical, and petrochemical, while industries such as automotive, and ‘other’ industries grown significantly not only as far their energy consumptions and related CO 2 emissions but they also increased their contributions to the national economy. - Highlights: ► Industrial CO 2 emission intensity was reduced by 26.2% from 1965 to 2003. ► Industrial CO 2 emission intensity was increased by 10.1% from 2003 to 2010. ► 1965–2003: Intensity effect took down CO 2 emission intensity. ► 2003–2010: Export-oriented industries raised CO 2 emission intensity.

  9. Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis

    Directory of Open Access Journals (Sweden)

    Lee HJ

    2014-12-01

    Full Text Available Hyo-Jeong Lee,1 Jakkid Sanetuntikul,2 Eun-Sook Choi,1 Bo Ram Lee,1 Jung-Hee Kim,1 Eunjoo Kim,1 Sangaraju Shanmugam2 1Nano and Bio Research Division, 2Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C particles using a single-component precursor, iron (III diethylenetriaminepentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light, the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm-2. These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. Keywords: graphitic carbon–encapsulated magnetic nanoparticles, iron oxide, one-pot synthesis, photothermal cancer therapy

  10. Stability of alcohol use and teen dating violence for female youth: A latent transition analysis.

    Science.gov (United States)

    Choi, Hye Jeong; Elmquist, JoAnna; Shorey, Ryan C; Rothman, Emily F; Stuart, Gregory L; Temple, Jeff R

    2017-01-01

    Alcohol use is one of the most widely accepted and studied risk factors for teen dating violence (TDV). Too little research has explored longitudinally if it is true that an adolescent's alcohol use and TDV involvement simultaneously occur. In the current study, we examined whether there were latent status based on past-year TDV and alcohol use and whether female adolescents changed their statuses of TDV and alcohol use over time. The sample consisted of 583 female youths in seven public high schools in Texas. Three waves of longitudinal data collected from 2011 to 2013 were utilised in this study. Participants completed self-report assessments of alcohol use (past-year alcohol use, number of drinks in the past month and episodic heavy drinking within the past month) and psychological and physical TDV victimisation and perpetration. Latent transition analysis was used to examine if the latent status based on TDV and alcohol use changed over time. Five separate latent statuses were identified: (i) no violence, no alcohol; (ii) alcohol; (iii) psychological violence, no alcohol; (iv) psychological violence, alcohol; and (v) physical and psychological violence, alcohol. Latent transition analysis indicated that adolescents generally remained in the same subgroup across time. This study provides evidence on the co-occurrence of alcohol use and teen dating violence, and whether teens' status based on dating violence and alcohol use are stable over time. Findings from the current study highlight the importance of targeting both TDV and substance use in intervention and prevention programs. [Choi HJ, Elmquist J, Shorey RC, Rothman EF, Stuart GL,Temple JR. Stability of alcohol use and teen dating violence for female youth: Alatent transition analysis. Drug Alcohol Rev 2017;36:80-87]. © 2017 Australasian Professional Society on Alcohol and other Drugs.

  11. Pemanfaatan Limbah Tahu untuk Peningkatan Hasil Tanaman Petsai (Brassica chinensis

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    YULIADI ASMORO

    2008-11-01

    Full Text Available A tofu industry potentially produced solid or liquid waste products which are potentially causing pollution. A good treatment of the wastes, waste of solid-wet tofu can be use d to make tempeh gem bus, cattle food and fish food, and the rest is also used as fertilizer especially for pak choi or petsai or Chinese cabbage (Brasssica chinensis L.. The aims of this research were examine: (i The effect of tofu wastes for yield of petsai plant, and (ii the effect of concentration of tofu waste to the yield of petsai plant. There are two methods: independent variable and dependent variable. The method which used was experiment. 20 petsai plants were planted into 20 pots to be treated with solid and liquid tofu wastes with concentration 110%, 20%, and 30%, while as the control 20 pot each 1 plant was treated without wastes. The nutrient contents both for the solid and liquid wastes were analyzed. The data were analyzed by Anova and the difference between means tested using Duncan s Multiple Range Test (DMRT at 5%% level of significant. The result indicated that increasing of petsai yields u sing solid tofu waste for concentration 10% is 94.06%, for concentration 20% is 3325.76%, and for 30% is 176.11%. The additional of liquid waste for concentration 10% is 41.226%, for concentration 200% is 64.34%% and for concentration 30% is 1.75%%, compared t o the control. Nitrogen contents (N of solid tofu waste and its organic material is higher than liquid waste one, so it has good effect for the plant growth, than liquid waste solution.

  12. Enhanced detection of single-cell-secreted proteins using a fluorescent immunoassay on the protein-G-terminated glass substrate

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    Jeong Y

    2015-11-01

    Full Text Available Yoon Jeong,1,2 Kwan Hong Lee,1,2 Hansoo Park,3 Jonghoon Choi1,2 1Department of Bionano Technology, Graduate School, Hanyang University, Seoul, 2Department of Bionano Engineering, Hanyang University ERICA, Ansan, 3School of Integrative Engineering, Chung-Ang University, Seoul, South Korea Abstract: We present an evaluation of protein-G-terminated glass slides that may contain a suitable substrate for aligning the orientation of antibodies to obtain better binding moiety to the target antigen. The results of the protein-G-terminated slides were compared with those obtained with epoxy-based slides to evaluate signal enhancement for human immunoglobulin G (IgG targets, and an increase in the average fluorescence intensity was observed for the lowest measurable amount of IgG target in the assay using protein-G-terminated slides. Applying this strategy for signal amplification to single-cell assays improves the limits of detection for human IgG protein and cytokines (interleukin-2 and interferon-γ captured from hybridomas. Our data indicate that protein-G-terminated slides have a higher binding capacity for antigens and have better spot-to-spot consistency than that of traditional epoxy-based slides. These properties would be beneficial in the detection of fine amounts of single-cell-secreted proteins, which may provide key insights into cell–cell communication and immune responses. Keywords: microwell array, antibody’s orientation, single cell analysis, secreted cytokine, protein-G-terminated surface

  13. Guidelines for Authors

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    Abdullah Demir

    2016-06-01

    . As’ad Abukhalil, “Maronites,” in Encyclopedia of the Modern Middle East and North Africa, ed. Philip Mattar, 2nd ed., vol. 3 (New York: Macmillan Reference, 2004, 1491-92.2. Abukhalil, “Maronites,” 1492.Bibliography: Abukhalil, As’ad. “Maronites.” In Encycloedia or the Modern Middle East and North Africa. Edited by Philip Mattar. 2nd ed. Vol. 3. New York: Macmillan Reference, 1491-92.    DISSERTATIONFor theses and dissertations, the following order should be followed: name of the author and surname, full title of thesis in italics, thesis type, the name of the university and date.1. Mihwa Choi, “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty” (PhD diss., University of Chicago, 2008, 55.2. Choi, “Contesting Imaginaires,” 59. Bibliography: Choi, Mihwa. “Contesting Imaginaires in Death Rituals during the Northern Song Dynasty.” PhD diss., University of Chicago, 2008. Chicago-Style Citation Quick Guide:http://www.chicagomanualofstyle.org/tools_citationguide.html 

  14. Tet1 overexpression leads to anxiety-like behavior and enhanced fear memories via the activation of calcium-dependent cascade through Egr1 expression in mice.

    Science.gov (United States)

    Kwon, Wookbong; Kim, Hyeng-Soo; Jeong, Jain; Sung, Yonghun; Choi, Minjee; Park, Song; Lee, Jinhee; Jang, Soyoung; Kim, Sung Hyun; Lee, Sanggyu; Kim, Myoung Ok; Ryoo, Zae Young

    2018-01-01

    Ten-eleven translocation methylcytosine dioxygenase 1 ( Tet1 ) initiates DNA demethylation by converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) at CpG-rich regions of genes, which have key roles in adult neurogenesis and memory. In addition, the overexpression of Tet1 with 5-hmC alteration in patients with psychosis has also been reported, for instance in schizophrenia and bipolar disorders. The mechanism underlying Tet1 overexpression in the brain; however, is still elusive. In the present study, we found that Tet1-transgenic (Tet1-TG) mice displayed abnormal behaviors involving elevated anxiety and enhanced fear memories. We confirmed that Tet1 overexpression affected adult neurogenesis with oligodendrocyte differentiation in the hippocampal dentate gyrus of Tet1-TG mice. In addition, Tet1 overexpression induced the elevated expression of immediate early genes, such as Egr1 , c-fos , Arc , and Bdnf , followed by the activation of intracellular calcium signals ( i.e. , CamKII, ERK, and CREB) in prefrontal and hippocampal neurons. The expression of GABA receptor subunits ( Gabra2 and Gabra4 ) fluctuated in the prefrontal cortex and hippocampus. We evaluated the effects of Tet1 overexpression on intracellular calcium-dependent cascades by activating the Egr1 promoter in vitro Tet1 enhanced Egr1 expression, which may have led to alterations in Gabra2 and Gabra4 expression in neurons. Taken together, we suggest that the Tet1 overexpression in our Tet1-TG mice can be applied as an effective model for studying various stress-related diseases that show hyperactivation of intracellular calcium-dependent cascades in the brain.-Kwon, W., Kim, H.-S., Jeong, J., Sung, Y., Choi, M., Park, S., Lee, J., Jang, S., Kim, S. H., Lee, S., Kim, M. O., Ryoo, Z. Y. Tet1 overexpression leads to anxiety-like behavior and enhanced fear memories via the activation of calcium-dependent cascade through Egr1 expression in mice. © FASEB.

  15. Hair dye-incorporated poly-γ-glutamic acid/glycol chitosan nanoparticles based on ion-complex formation

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    Lee HY

    2011-11-01

    Full Text Available Hye-Young Lee1,*, Young-IL Jeong2,*, Ki-Choon Choi31Anyang Science University, Anyang, Gyeonggi, South Korea; 2Chonnam National University Hwasun Hospital, Jeonnam, South Korea; 3Grassland and Forages Research Center, National Institute of Animal Science, Rural Development Administration, Chungnam, South Korea*These authors contributed equally to this work.Background: p-Phenylenediamine (PDA or its related chemicals are used more extensively than oxidative hair dyes. However, permanent hair dyes such as PDA are known to have potent contact allergy reactions in humans, and severe allergic reactions are problematic.Methods: PDA-incorporated nanoparticles were prepared based on ion-complex formation between the cationic groups of PDA and the anionic groups of poly(γ-glutamic acid (PGA. To reinforce PDA/PGA ion complexes, glycol chitosan (GC was added. PDA-incorporated nanoparticles were characterized using field-emission scanning electron microscopy, Fourier-transform infrared (FT-IR spectroscopy, dynamic light scattering, and powder X-ray diffractometry (XRD.Results: Nanoparticles were formed by ion-complex formation between the amine groups of PDA and the carboxyl groups of PGA. PDA-incorporated nanoparticles are small in size (<100 nm, and morphological observations showed spherical shapes. FT-IR spectra results showed that the carboxylic acid peak of PGA decreased with increasing PDA content, indicating that the ion complexes were formed between the carboxyl groups of PGA and the amine groups of PDA. Furthermore, the intrinsic peak of the carboxyl groups of PGA was also decreased by the addition of GC. Intrinsic crystalline peaks of PDA were observed by XRD. This crystalline peak of PDA was completely nonexistent when nanoparticles were formed by ion complex between PDA, PGA, and GC, indicating that PDA was complexed with PGA and no free drug existed in the formulation. During the drug-release experiment, an initial burst release of PDA was

  16. Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

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    Lee JA

    2014-12-01

    Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

  17. Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway

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    Soni KK

    2017-10-01

    Full Text Available Kiran Kumar Soni,1,* Yu Seob Shin,1,* Bo Ram Choi,1 Keshab Kumar Karna,1 Hye Kyung Kim,2 Sung Won Lee,3 Chul Young Kim,4 Jong Kwan Park1 1Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Clinical Trial Center of Medical Device of Chonbuk National University, Jeonju, 2College of Pharmacy, Kyungsung University, Busan, 3Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University Medical School, Seoul, 4College of Pharmacy, Hangyang University, Ansan, Republic of Korea *These authors contributed equally to this work Abstract: Finasteride is used to treat male pattern baldness and benign prostatic hyperplasia. This study investigated the toxicity of finasteride and recovery by DA-9401 using Sprague Dawley (SD rats. Forty adult male SD rats were assigned to four groups: control (CTR, finasteride 1 mg/kg/day (F, finasteride 1 mg/kg + DA-9401 100 mg/kg/day (F + DA 100 and finasteride 1 mg/kg + DA-9401 200 mg/kg/day (F + DA 200. Treatments were by oral delivery once daily for 90 consecutive days. The gross anatomical parameters assessed included: genital organ weight; vas deferens sperm count and sperm motility; testosterone, dihydrotestosterone (DHT and malondialdehyde levels; and histological and terminal deoxynucleotidyl transferase enzyme mediated dUTP nick-end labeling (TUNEL staining of testis for spermatogenic cell density, Johnsen’s score and apoptosis. Testicular tissue was also used for evaluating endoplasmic reticulum (ER stress and apoptotic proteins. Epididymis weight, seminal vesicle weight, prostate weight, penile weight and vas deferens sperm motility showed significant differences between the F group and the CTR, F + DA 100 and F + DA 200 groups. There was no significant change in the testosterone level. DHT level decreased significantly in the F group compared with the CTR

  18. Multicomponent, peptide-targeted glycol chitosan nanoparticles containing ferrimagnetic iron oxide nanocubes for bladder cancer multimodal imaging

    Directory of Open Access Journals (Sweden)

    Key J

    2016-08-01

    Full Text Available Jaehong Key,1,2 Deepika Dhawan,3 Christy L Cooper,3,4 Deborah W Knapp,3 Kwangmeyung Kim,5 Ick Chan Kwon,5 Kuiwon Choi,5 Kinam Park,1,6 Paolo Decuzzi,7–9 James F Leary1,3,41Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA; 2Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea; 3School of Veterinary Medicine-Department of Basic Medical Sciences, Purdue University, West Lafayette, 4Birck Nanotechnology Center at Discovery Park, Purdue University, West Lafayette, IN, USA; 5Biomedical Research Center, Korea Institute of Science and Technology, Sungbook-Gu, Seoul, Republic of Korea; 6Department of Pharmaceutics, Purdue University, West Lafayette, IN, 7Department of Translational Imaging, 8Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX USA; 9Laboratory of Nanotechnology for Precision Medicine, Fondazione Istituto Italiano di Tecnologia (IIT, Genova, Italy Abstract: While current imaging modalities, such as magnetic resonance imaging (MRI, computed tomography, and positron emission tomography, play an important role in detecting tumors in the body, no single-modality imaging possesses all the functions needed for a complete diagnostic imaging, such as spatial resolution, signal sensitivity, and tissue penetration depth. For this reason, multimodal imaging strategies have become promising tools for advanced biomedical research and cancer diagnostics and therapeutics. In designing multimodal nanoparticles, the physicochemical properties of the nanoparticles should be engineered so that they successfully accumulate at the tumor site and minimize nonspecific uptake by other organs. Finely altering the nano-scale properties can dramatically change the biodistribution and tumor accumulation of nanoparticles in the body. In this study, we engineered multimodal nanoparticles for both MRI, by using ferrimagnetic nanocubes (NCs, and near infrared fluorescence imaging

  19. Silver nanoparticles cause complications in pregnant mice

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    Zhang XF

    2015-11-01

    Full Text Available Xi-Feng Zhang,1,2 Jung-Hyun Park,1 Yun-Jung Choi,1 Min-Hee Kang,1 Sangiliyandi Gurunathan,1 Jin-Hoi Kim11Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea; 2College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, People’s Republic of ChinaBackground: Silver nanoparticles (AgNPs have attracted much interest and have been used for antibacterial, antifungal, anticancer, and antiangiogenic applications because of their unique properties. The increased usage of AgNPs leads to a potential hazard to human health. However, the potential effects of AgNPs on animal models are not clear. This study was designed to investigate the potential impact of AgNPs on pregnant mice.Methods: The synthesis of AgNPs was performed using culture extracts of Bacillus cereus. The synthesized AgNPs were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, and transmission electron microscopy. AgNPs were administrated into pregnant mice via intravenous infusion at 1.0 mg/kg doses at 6.5 days postcoitum (dpc. At 13.5, 15.5, and 17.5 dpc, the pregnant mice were euthanized, and the embryo and placenta were isolated. The meiotic status of oocytes was evaluated. DNA methylation studies were performed, and aberrant imprinting disrupted fetal, placental, and postnatal development. Quantitative real-time polymerase chain reaction analysis and Western blot were used to analyze various gene expressions.Results: The synthesized AgNPs were uniformly distributed and were spherical in shape with an average size of 8 nm. AgNPs exposure increased the meiotic progression of female germ cells in the fetal mouse ovaries, and maternal AgNP exposure significantly disrupted imprinted gene expression in 15.5 dpc embryos and placentas, such as Ascl2, Snrpn, Kcnq1ot1, Peg3, Zac1, H19, Igf2r, and Igf2; DNA methylation studies revealed that AgNPs exposure significantly altered the methylation levels of

  20. Efficacy and safety of tamsulosin hydrochloride 0.2 mg and combination of tamsulosin hydrochloride 0.2 mg plus solifenacin succinate 5 mg after transurethral resection of the prostate: a prospective, randomized controlled trial

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    Shin YS

    2016-09-01

    Full Text Available Yu Seob Shin,1,* Li Tao Zhang,1,* Jae Hyung You,1 In Sung Choi,1 Chen Zhao,2 Jong Kwan Park1 1Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute and Medical Device Clinical Trial Center of Chonbuk National University, Jeonju, Republic of Korea; 2Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, and Shanghai Institute of Andrology, Shanghai, People’s Republic of China *These authors contributed equally to this work Objective: The objective of this study was to evaluate the safety and efficacy of tamsulosin hydrochloride 0.2 mg (TAM and its combination with solifenacin succinate 5 mg (SOL after transurethral resection of the prostate (TURP.Patients and methods: The patients were randomized into three groups: TURP (group 1, TURP plus TAM (group 2, and TURP plus TAM + SOL (group 3. Patients in group 2 and group 3 received medication for 4 weeks. The primary efficacy end points were the mean change in total International Prostate Symptom Score (IPSS and IPSS subscores. The secondary end points included quality-of-life score, Overactive Bladder Symptom Score, and short-form voiding and storage score of International Continence Society.Results: In total, 37 men (31.8% in group 1, 37 men (31.8% in group 2, and 42 men (36.2% in group 3 completed the study. In total IPSS, no significant improvement was seen from baseline to the end of treatment in groups 2 and 3 compared with group 1. However, in group 2, the decrement in the IPSS storage score was smaller than group 1 (P=0.02, and in group 3, the decrement in the IPSS voiding score was smaller than group 1 (P=0.05. In groups 2 and 3 compared with group 1, improvements in the quality of life score, total score of Overactive Bladder Symptom Score, and short-form voiding score and storage score of International Continence Society were not statistically

  1. Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

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    Ahn KT

    2016-04-01

    Full Text Available Kye Taek Ahn, Kwang-In Park, Mi Joo Kim, Jin Kyung Oh, Ji Hye Han, Hee Jin Kwon, Seon-Ah Jin, Jun-Hyung Kim, Jae-Hyeong Park, Jae-Hwan Lee, Si Wan Choi, In-Whan Seong, Jin-Ok Jeong Department of Internal Medicine, Division of Cardiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea Objectives: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. Methods: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg were enrolled. Central blood pressure and radial augmentation index (AIx corrected for a heart rate of 75 bpm (radial AIx 75 were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. Results: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%. The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=-0.627 for height, R=0.035 for age, P-value =0.005, a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R2=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=-0.632, 95% CI for height -0.929 to -0.335, P-value =0.009, respectively. Conclusion: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. Keywords: hypertension, augmentation index, height, sex

  2. PSEN1 L226F mutation in a patient with early-onset Alzheimer’s disease in Korea

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    Bagyinszky E

    2016-10-01

    Full Text Available Eva Bagyinszky,1,* Sun Ah Park,2,* Hyung Jun Kim,2 Seong Hye Choi,3 Seong Soo A An,1 SangYun Kim4 1Department of BioNano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Inha University School of Medicine, Incheon, 4Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: In this study, we report a first 226leucine (Leu mutation to phenylalanine (Phe in (PSEN1, CTC>TTC, L226F in Asia from a Korean early-onset Alzheimer’s disease (EOAD patient. Polymerase chain reaction (PCR–single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age, but the mutation seemed to be de novo, since no affected family member was found. This leucine to phenylalanine substitution may cause additional stresses inside the transmembrane region due to large aromatic side chain and increased hydrophobic interactions with hydrocarbon chains in the membrane and its binding partners. Clinical phenotype of the mutation was aggressive progression into neurodegeneration, resulting in rapid cognitive decline. One of the patients was initially diagnosed with frontotemporal dementia, but the diagnosis was revised to AD upon postmortem studies in which Aβ plaques were seen. A second mutation, L226R, was found for the L226 residue. Similar to L226F, the patient with L226R also developed the first symptoms in his 30s, but EOAD was diagnosed in his 40s. These findings suggested that L226 might be an important residue in PSEN1

  3. Orthotopic liver transplantation after the combined use of locoregional therapy and sorafenib for advanced hepatocellular carcinoma

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    Yoo EJ

    2013-06-01

    Full Text Available Eun Jin Yoo,1,* Hye Sun Shin,1,* Seung Up Kim,1,2,7 Dong Jin Joo,3,4 Jun Yong Park,1,2,7 Gi Hong Choi,3 Do Young Kim,1,2,7 Sang Hoon Ahn,1,2,7 Jinsil Seong,5 Myung Joo Koh,6 Kwang-Hyub Han,1,2,7 Chae Yoon Chon1,2,7 1Department of Internal Medicine, 2Institute of Gastroenterology, 3Department of Surgery, 4Research Institute for Transplantation, 5Department of Radiation Oncology, 6Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea; 7Liver Cirrhosis Clinical Research Center, Seoul, South Korea *These authors contributed equally to this work Abstract: We herein report a patient with advanced hepatitis B virus-related hepatocellular carcinoma (HCC beyond the Milan criteria. He underwent orthotopic liver transplantation after successful HCC downstaging that satisfied the University of California, San Francisco criteria, using concurrent chemoradiation therapy with a combination of repeated hepatic arterial infusion chemotherapy (HAIC and sorafenib. A 52-year-old male was diagnosed with advanced hepatitis B virus-related HCC beyond the Milan criteria. He underwent concurrent chemoradiation therapy (50 Gy with 20 fractions over 5 weeks with HAIC using 5-fluorouracil at a dose of 500 mg/day, which was administered during the first and fifth weeks of radiation therapy as an initial treatment modality. This was followed by the combined use of HAIC using 5-fluorouracil (500 mg/m2 for 5 hours on days 1–3 and cisplatin (60 mg/m2 for 2 hours on day 2 every 4 weeks (twelve cycles and sorafenib (from the third to the twelfth cycle of HAIC to treat the remaining HCC. Because a remarkable decrease in the tumor burden that satisfied the University of California, San Francisco criteria was observed after these combination treatments, the patient underwent orthotopic liver transplantation with curative aim and survived for 11 months without evidence of HCC recurrence. Keywords: hepatocellular carcinoma, liver transplantation

  4. Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

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    Yousaf AM

    2016-01-01

    Full Text Available Abid Mehmood Yousaf,1,2 Omer Mustapha,1 Dong Wuk Kim,1 Dong Shik Kim,1 Kyeong Soo Kim,1 Sung Giu Jin,1 Chul Soon Yong,3 Yu Seok Youn,4 Yu-Kyoung Oh,5 Jong Oh Kim,3 Han-Gon Choi1 1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi, South Korea; 2Faculty of Pharmacy, University of Central Punjab, Johar, Lahore, Pakistan; 3College of Pharmacy, Yeungnam University, Gyongsan, North Gyeongsang, 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, 5College of Pharmacy, Seoul National University, Seoul, South Korea Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1

  5. Safety, tolerability, pharmacokinetics, and pharmacodynamics of novel glucokinase activator HMS5552: results from a first-in-human single ascending dose study

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    Xu HR

    2016-05-01

    Full Text Available Hongrong Xu,1,* Lei Sheng,1,* Weili Chen,1 Fei Yuan,1 Mengjie Yang,1 Hui Li,1 Xuening Li,1 John Choi,2 Guiyu Zhao,2 Tianxin Hu,2 Yongguo Li,2 Yi Zhang,2 Li Chen2 1Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, 2Department of Clinical Research & Development, Hua Medicine, Shanghai, People’s Republic of China *These authors have contributed equally to this work Background: HMS5552, a novel fourth-generation glucokinase (GK activator, has demonstrated promising effects on glycemic control in preclinical models of type 2 diabetes. This single ascending dose study was conducted to investigate the safety, tolerability, pharmacokinetics (PK, and pharmacodynamics (PD of HMS5552 during its first-in-human exposure.Methods: Sixty healthy subjects were enrolled. In each of six dose-cohorts (5, 10, 15, 25, 35, and 50 mg, ten subjects were randomized with eight subjects receiving the same cohort-dose of HMS5552 and two receiving placebo. Plasma HMS5552 exposure, glucose, and insulin were measured repeatedly during fasting and after a standardized meal. Assessment included safety, PK, and PD endpoints.Results: HMS5552 showed dose-proportional increases in area under the curve 0 to the last quantifiable concentration (AUC0–t and maximum plasma concentration (Cmax. Slopes estimated by linear regression for AUC0–t and Cmax were ~1.0 (0.932 and 0.933, respectively. Geometric mean elimination half-life ranged from 4.48 to 7.51 hours and apparent clearance ranged from 11.5 to 13.1 L/h across all doses. No significant sex effect was observed in PK parameters. HMS5552 also demonstrated dose-related PD responses in terms of maximum glucose change from baseline (% and mean glucose area under effect curve 0–4 hours change from baseline (% (P<0.001. Fifteen adverse events were reported by nine subjects (ten with HMS5552 and five with the placebo. All adverse events were mild in intensity and resolved without any treatment

  6. An investigation of coseismic OSL / TL time zeroing of quartz gouge based on low- to high-velocity friction experiments

    Science.gov (United States)

    Akasegawa, K.; Oohashi, K.; Hasebe, N.; Miura, K.

    2016-12-01

    Shimamoto, T., 2004. Bull. Nara Univ. Educ., Vol. 53, No. 2, 17-29. Ikeya, M., Miki, T. and Tanaka, K. 1982. Seience, 215, 1392-1393. Kim, J. H., Choi, J. H., Chauhan, N., Lee, S., Hirose, T., and Ree, J. H, 2014. AGU, Fall Meeting 2014.

  7. Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards

    Science.gov (United States)

    Ham, H. J.; Lee, S.; Choi, S. H.; Yun, W. S.

    2015-12-01

    Agricultural Fragility Estimates Subjected to Volcanic Ash Fall Hazards Hee Jung Ham1, Seung-Hun Choi1, Woo-Seok Yun1, Sungsu Lee2 1Department of Architectural Engineering, Kangwon National University, Korea 2Division of Civil Engineering, Chungbuk National University, Korea ABSTRACT In this study, fragility functions are developed to estimate expected volcanic ash damages of the agricultural sector in Korea. The fragility functions are derived from two approaches: 1) empirical approach based on field observations of impacts to agriculture from the 2006 eruption of Merapi volcano in Indonesia and 2) the FOSM (first-order second-moment) analytical approach based on distribution and thickness of volcanic ash observed from the 1980 eruption of Mt. Saint Helens and agricultural facility specifications in Korea. Fragility function to each agricultural commodity class is presented by a cumulative distribution function of the generalized extreme value distribution. Different functions are developed to estimate production losses from outdoor and greenhouse farming. Seasonal climate influences vulnerability of each agricultural crop and is found to be a crucial component in determining fragility of agricultural commodities to an ash fall. In the study, the seasonality coefficient is established as a multiplier of fragility function to consider the seasonal vulnerability. Yields of the different agricultural commodities are obtained from Korean Statistical Information Service to create a baseline for future agricultural volcanic loss estimation. Numerically simulated examples of scenario ash fall events at Mt. Baekdu volcano are utilized to illustrate the application of the developed fragility functions. Acknowledgements This research was supported by a grant 'Development of Advanced Volcanic Disaster Response System considering Potential Volcanic Risk around Korea' [MPSS-NH-2015-81] from the Natural Hazard Mitigation Research Group, Ministry of Public Safety and Security of

  8. Tai chi qigong as a means to improve night-time sleep quality among older adults with cognitive impairment: a pilot randomized controlled trial

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    Chan AWK

    2016-09-01

    Full Text Available Aileen WK Chan, Doris SF Yu, KC Choi, Diana TF Lee, Janet WH Sit, Helen YL Chan The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China Purpose: Age-related cognitive decline is a growing public health concern worldwide. More than a quarter of adults with cognitive impairment experience sleep disturbance. The objective of this pilot study was to evaluate the preliminary effects of tai chi qigong (TCQ on improving the night-time sleep quality of older adults with cognitive impairment. Participants: Older adults with cognitive impairment who complain of sleep disturbance. Methods: A randomized controlled trial with two groups. Fifty-two subjects were recruited from two district elderly community centers and randomly assigned to either the TCQ group (n=27 or the control group (n=25. The intervention group received TCQ training consisting of two 60-minute sessions each week for 2 months. The control group was advised to maintain their usual activities. Sleep quality was measured by the Chinese Pittsburgh Sleep Quality Index. Quality of life was measured by Short-form 12, cognitive functions measured by mini-mental state examination, and subjective memory deficits measured by the memory inventory for Chinese. Results: Data were collected at baseline, 2 months, and 6 months. Significant results were noted at 6 months in the Chinese Pittsburgh Sleep Quality Index global score (P=0.004, sleep duration (P=0.003, habitual sleep efficiency (P=0.002, and the Short-form 12 mental health component (P<0.001. The TCQ participants reported better sleep quality and a better (quality of life mental health component than the control group. Conclusion: TCQ can be considered a useful nonpharmacological approach for improving sleep quality in older adults with cognitive impairment.Clinical trial registration: CUHK_CCT00448 (https://www2.ccrb.cuhk.edu.hk/registry/public/287. Keywords: cognitive decline, mind

  9. Neurogenic effects of fingolimod in hippocampus, affecting fear memory.

    Directory of Open Access Journals (Sweden)

    Paschalis Efstathopoulos

    2014-05-01

    Full Text Available Fingolimod (FTY720; Gilenya™,Novartis Pharma AG is a recently developed Sphingosine-1-Phosphate (S1P analogue, orally administered as a new therapeutic agent in Multiple Sclerosis (MS (Brinkmann V. et al. 2010. S1P receptors (S1PRs are expressed in various sites in the CNS including the subventricular zone (Waeber C. et al. 1999; Choi J.W. et al. 2013 while endogenous S1P was shown to induce proliferation and morphological changes in embryonic hippocampal neural progenitors in culture (Harada J. et al. 2004. In this study we investigated the effects of fingolimod on adult rodent hippocampal neurogenesis and their possible functional role. To this aim, thymidine analogue BrdU was injected at the end or before a 2-week i.p. administration of a therapeutic dose of Fingolimod (0,3 mg/kg in young and old mice. Stereological counts of BrdU+ cells revealed significant increase in both proliferation, and survival of neural stem cells (NSC in the area of Dentate Gyrus (DG of the hippocampus, compared to control untreated animals of young but not old ages. In the case of survival assessment, most of the BrdU + cells were also positive for NeuN, suggesting an increase of newly formed neurons. The increase in proliferation rate of NSC was also confirmed by BrdU uptake in hippocampal NSC cultures in vitro, implying that the effects of fingolimod are cell autonomous. Immunohistochemical analysis showed that S1PR was not co-localized with GFAP+ cells in the Subgranular zone (SGZ of the DG, but was strongly co-localized with transcription factor MASH1 and weakly with DcX or PSA-NCAM positive neural progenitors. These findings suggest that expression of S1PR1 in the SGZ is restricted to transit amplifying neural progenitors and maintained also in the stage of neuroblast. In addition, the effects of Fingolimod in DG neurogenesis were positively correlated to enhanced fear memory and increased context discrimination, an established DG-dependent cognitive task

  10. Recent Progress on ECH Technology for ITER

    Science.gov (United States)

    Sirigiri, Jagadishwar

    2005-10-01

    The Electron Cyclotron Heating and Current Drive (ECH&CD) system for ITER is a critical ITER system that must be available for use on Day 1 of the ITER experimental program. The applications of the system include plasma start-up, plasma heating and suppression of Neoclassical Tearing Modes (NTMs). These applications are accomplished using 27 one megawatt continuous wave gyrotrons: 24 at a frequency of 170 GHz and 3 at a frequency of 120 GHz. There are DC power supplies for the gyrotrons, a transmission line system, one launcher at the equatorial plane and three upper port launchers. The US will play a major role in delivering parts of the ECH&CD system to ITER. The present state-of-the-art includes major advances in all areas of ECH technology. In the US, a major effort is underway to supply gyrotrons of up to 1.5 MW power level at 110 GHz to General Atomics for use in heating the DIII-D tokamak. This presentation will include a brief review of the state-of-the-art, worldwide, in ECH technology. The requirements for the ITER ECH&CD system will then be reviewed. ITER calls for gyrotrons capable of operating from a 50 kV power supply, after potential depression, with a minimum of 50% overall efficiency. This is a very significant challenge and some approaches to meeting this goal will be presented. Recent experimental results at MIT showing improved efficiency of high frequency, 1.5 MW gyrotrons will be described. These results will be incorporated into the planned development of gyrotrons for ITER. The ITER ECH&CD system will also be a challenge to the transmission lines, which must operate at high average power at up to 1000 seconds and with high efficiency. The technology challenges and efforts in the US and other ITER parties to solve these problems will be reviewed. *In collaboration with E. Choi, C. Marchewka, I. Mastovosky, M. A. Shapiro and R. J. Temkin. This work is supported by the Office of Fusion Energy Sciences of the U. S. Department of Energy.

  11. Sex differences in the effect of aging on dry eye disease

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    Ahn JH

    2017-08-01

    Full Text Available Jong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim1 1Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea Purpose: Aging is a major risk factor in dry eye disease (DED, and understanding sexual differences is very important in biomedical research. However, there is little information about sex differences in the effect of aging on DED. We investigated sex differences in the effect of aging and other risk factors for DED.Methods: This study included data of 16,824 adults from the Korea National Health and Nutrition Examination Survey (2010–2012, which is a population-based cross-sectional survey. DED was defined as the presence of frequent ocular dryness or a previous diagnosis by an ophthalmologist. Basic sociodemographic factors and previously known risk factors for DED were included in the analyses. Linear regression modeling and multivariate logistic regression modeling were used to compare the sex differences in the effect of risk factors for DED; we additionally performed tests for interactions between sex and other risk factors for DED in logistic regression models.Results: In our linear regression models, the prevalence of DED symptoms in men increased with age (R=0.311, P=0.012; however, there was no association between aging and DED in women (P>0.05. Multivariate logistic regression analyses showed that aging in men was not associated with DED (DED symptoms/diagnosis: odds ratio [OR] =1.01/1.04, each P>0.05, while aging in women was protectively associated with DED (DED symptoms/diagnosis: OR =0.94/0.91, P=0.011/0.003. Previous ocular surgery was significantly associated with DED in both men and women (men/women: OR =2.45/1.77 [DED symptoms] and 3.17/2.05 [DED diagnosis], each P<0.001. Tests for

  12. Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

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    Gurunathan S

    2015-10-01

    Full Text Available Sangiliyandi Gurunathan, Jae Woong Han, Jung Hyun Park, Eunsu Kim, Yun-Jung Choi, Deug-Nam Kwon, Jin-Hoi Kim Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea Background: Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initially respond to chemotherapy, but eventually acquire chemoresistance. Consequently, the development of novel molecules for cancer therapy is essential. This study was designed to develop a simple, non-toxic, environmentally friendly method for the synthesis of reduced graphene oxide–silver (rGO–Ag nanoparticle nanocomposites using Tilia amurensis plant extracts as reducing and stabilizing agents. The anticancer properties of rGO–Ag were evaluated in ovarian cancer cells. Methods: The synthesized rGO–Ag nanocomposite was characterized using various analytical techniques. The anticancer properties of the rGO–Ag nanocomposite were evaluated using a series of assays such as cell viability, lactate dehydrogenase leakage, reactive oxygen species generation, cellular levels of malonaldehyde and glutathione, caspase-3 activity, and DNA fragmentation in ovarian cancer cells (A2780. Results: AgNPs with an average size of 20 nm were uniformly dispersed on graphene sheets. The data obtained from the biochemical assays indicate that the rGO–Ag nanocomposite significantly inhibited cell viability in A2780 ovarian cancer cells and increased lactate dehydrogenase leakage, reactive oxygen species generation, caspase-3 activity, and DNA fragmentation compared with other tested nanomaterials such as graphene oxide, rGO, and AgNPs. Conclusion: T. amurensis plant extract

  13. IAGA Geomagnetic Data Analysis format - Analysis_IAGA

    Science.gov (United States)

    -Emilian Toader, Victorin; Marmureanu, Alexandru

    2013-04-01

    Geomagnetic research involves a continuous Earth's magnetic field monitoring and software for processing large amounts of data. The Analysis_IAGA program reads and analyses files in IAGA2002 format used within the INTERMAGNET observer network. The data is made available by INTERMAGNET (http://www.intermagnet.org/Data_e.php) and NOAA - National Geophysical Data Center (ftp://ftp.ngdc.noaa.gov/wdc/geomagnetism/data/observatories/definitive) cost free for scientific use. The users of this software are those who study geomagnetism or use this data along with other atmospheric or seismic factors. Analysis_IAGA allows the visualization of files for the same station, with the feature of merging data for analyzing longer time intervals. Each file contains data collected within a 24 hour time interval with a sampling rate of 60 seconds or 1 second. Adding a large number of files may be done by dividing the sampling frequency. Also, the program has the feature of combining data files gathered from multiple stations as long as the sampling rate and time intervals are the same. Different channels may be selected, visualized and filtered individually. Channel properties can be saved and edited in a file. Data can be processed (spectral power, P / F, estimated frequency, Bz/Bx, Bz/By, convolutions and correlations on pairs of axis, discrete differentiation) and visualized along with the original signals on the same panel. With the help of cursors/magnifiers time differences can be calculated. Each channel can be analyzed separately. Signals can be filtered using bandpass, lowpass, highpass (Butterworth, Chebyshev, Inver Chebyshev, Eliptic, Bessel, Median, ZeroPath). Separate graphics visualize the spectral power, frequency spectrum histogram, the evolution of the estimated frequency, P/H, the spectral power. Adaptive JTFA spectrograms can be selected: CSD (Cone-Shaped Distribution), CWD (Choi-Williams Distribution), Gabor, STFT (short-time Fourier transform), WVD (Wigner

  14. Physical Processes Involved In Yellow Sea Solitary Waves

    Science.gov (United States)

    Warn-Varnas, A.; Chin-Bing, S.; King, D.; Lamb, K.; Hawkins, J.; Teixeira, M.

    The study area is located south of the Shandong peninsula. In this area, soliton gener- ation and propagation studies are per formed with the Lamb(1994) model. The model is nonhydrostatic and is formulated in 2 1/2 dimensions for terrain following c oordi- nates. In the area, 20 to 30 m topographic variations over distances of 10 to 20 km are found to occur in the digit al atlas of Choi (1999). The area is shallow with maximum depths ranging from 40 m to 70 m. Along the southern boundary of the region the semi-diurnal tidal strength magnitude varies from .6 m/sec to 1.2 m/sec, Fang(1994). We show that, for sum mer conditions, the existing physical processes associated with the semi-diurnal tidal flow over the topographic variations , in the shelfbreak region, lead to the formation of internal bores in the model simulations. Through acting phys- ical proce sses, the internal bores propagate on and off the shelf. A disintegration process of internal bores into solitary waves occ urs through frequency and ampli- tude dispersion. SAR observations of the area show images containing six events con- sisting of internal bores and solitary waves that travel in a well-defined direction for two and a half days. The origin of the trains appeared to be at a point along a steep topo graphic drop. The SAR observations are used for guiding and tuning the model simulations, by comparing spectra of observed and modeled wavelengths. The tuned model yields wavelengths that are within a factor of 2 of the SAR data. The modeled amp litudes are within a factor of 2 of amplitudes obtained with a two-layer model and the SAR data The signature on the acoustical field of ongoing physical processes through the interaction of the resultant oceanic struct ure with the acoustical field is pursued. Internal bore and solitary wave structures interact with the acoustic field. A re distribution of acoustical energy to higher acoustical modes occurs at some fre- quencies. Mode decomposition of the

  15. Nitrate from Drinking Water and Diet and Bladder Cancer Among Postmenopausal Women in Iowa.

    Science.gov (United States)

    Jones, Rena R; Weyer, Peter J; DellaValle, Curt T; Inoue-Choi, Maki; Anderson, Kristin E; Cantor, Kenneth P; Krasner, Stuart; Robien, Kim; Freeman, Laura E Beane; Silverman, Debra T; Ward, Mary H

    2016-11-01

    nitrite intakes were not associated with bladder cancer. Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. Citation: Jones RR, Weyer PJ, DellaValle CT, Inoue-Choi M, Anderson KE, Cantor KP, Krasner S, Robien K, Beane Freeman LE, Silverman DT, Ward MH. 2016. Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspect 124:1751-1758; http://dx.doi.org/10.1289/EHP191.

  16. Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis

    Directory of Open Access Journals (Sweden)

    Suh JS

    2014-03-01

    Full Text Available Jin Sook Suh,1,* Jue Yeon Lee,2,* Yoon Jung Choi,1 Hyung Keun You,3 Seong-Doo Hong,4 Chong Pyoung Chung,2 Yoon Jeong Park1,2 1Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, 2Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC, Seoul, 3Department of Periodontology, College of Dentistry, Wonkwang University, Iksan, 4Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Protein-transduction technology has been attempted to deliver macromolecular materials, including protein, nucleic acids, and polymeric drugs, for either diagnosis or therapeutic purposes. Herein, fusion protein composed of an arginine-rich cell-penetrating peptide, termed low-molecular-weight protamine (LMWP, and a transcriptional coactivator with a PDZ-binding motif (TAZ protein was prepared and applied in combination with biomaterials to increase bone-forming capacity. TAZ has been recently identified as a specific osteogenic stimulating transcriptional coactivator in human mesenchymal stem cell (hMSC differentiation, while simultaneously blocking adipogenic differentiation. However, TAZ by itself cannot penetrate the cells, and thus needs a transfection tool for translocalization. The LMWP-TAZ fusion proteins were efficiently translocalized into the cytosol of hMSCs. The hMSCs treated with cell-penetrating LMWP-TAZ exhibited increased expression of osteoblastic genes and protein, producing significantly higher quantities of mineralized matrix compared to free TAZ. In contrast, adipogenic differentiation of the hMSCs was blocked by treatment of LMWP-TAZ fusion protein, as reflected by reduced marker-protein expression, adipocyte fatty acid-binding protein 2, and peroxisome proliferator-activated receptor-γ messenger ribonucleic acid levels. LMWP-TAZ was applied in

  17. Dose-dependent effects of cisplatin on the severity of testicular injury in Sprague Dawley rats: reactive oxygen species and endoplasmic reticulum stress

    Directory of Open Access Journals (Sweden)

    Soni KK

    2016-12-01

    Full Text Available Kiran Kumar Soni,1 Hye Kyung Kim,2 Bo Ram Choi,1 Keshab Kumar Karna,1 Jae Hyung You,1 Jai Seong Cha,1 Yu Seob Shin,1 Sung Won Lee,3 Chul Young Kim,4 Jong Kwan Park1 1Department of Urology, Institute for Medical Sciences, Chonbuk National University Medical School – Biomedical Research and Institute and Clinical Trial Center for Medical Devices, Chonbuk National University Hospital, Jeonju, 2College of Pharmacy, Kyungsung University, Busan, 3Department of Urology, Samsung Medical Center, Samsung Biomedical Research Institute, Sungkyunkwan University Medical School, Seoul, 4College of Pharmacy, Hanyang University, Ansan, Republic of Korea Abstract: Cisplatin (CIS is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts of the body. This study investigated the severity of CIS toxicity by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment groups and control group with CIS (2, 4, 6, 8, and 10 mg/kg administered intraperitoneally for 5 days. The body and organs were weighed, epididymal sperm was counted, and sperm motility and sperm apoptosis were evaluated. Blood samples were evaluated for complete blood count, reactive oxygen and nitrogen species, malondialdehyde levels, and total testosterone. The testicular tissue was examined for steroidogenic acute regulatory protein and endoplasmic reticulum stress protein. Epididymal sperm was collected for CatSper Western blot. The toxic effects of different doses of CIS on the testis and kidney were compared histologically. The weights of body, testis, epididymis, prostate, seminal vesicle, and kidney; sperm count; sperm motility; steroidogenic acute regulatory protein level; and epididymal sperm count were significantly lower in the CIS-treated groups than in the control group. In contrast, sperm apoptosis, plasma reactive oxygen and nitrogen species, and malondialdehyde, testosterone, red blood cell

  18. Effects of dexamethasone coadministered with oseltamivir on the pharmacokinetics of oseltamivir in healthy volunteers

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    Jang K

    2017-03-01

    Full Text Available Kyungho Jang,1,2,* Min-Kyoung Kim,3,4,* Jaeseong Oh,1 SeungHwan Lee,1 Joo-Youn Cho,1 Kyung-Sang Yu,1 Tai Kiu Choi,3 Sang-Hyuk Lee,3,4 Kyoung Soo Lim4 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Center for Clinical Pharmacology and Biomedical Research Institute, Chonbuk National University Medical School, Jeonju, 3Department of Psychiatry, 4Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, Republic of Korea *These authors contributed equally to this work Purpose: Oseltamivir is widely used in the treatment and prophylaxis of influenza A and B viral infections. It is ingested as an oral prodrug that is rapidly metabolized by carboxylesterase 1 (CES1 to its active form, oseltamivir carboxylate. Dexamethasone is also used in the treatment of acute respiratory distress syndrome, a severe complication of influenza; however, its influence on the pharmacokinetics (PK of oseltamivir is controversial. The aim of this study was to investigate the effects of coadministering oseltamivir and dexamethasone on the PK of oseltamivir in healthy volunteers. Methods: An open-label, two-period, one-sequence, multiple-dose study was conducted in 19 healthy male volunteers. Oseltamivir (75 mg was orally administered on Day 1 and Day 8, and dexamethasone (1.5 mg was administered once daily from Day 3 to Day 8. Serial blood and urine samples were collected for PK analysis of oseltamivir and oseltamivir carboxylate on Day 1 and Day 8. Oseltamivir and oseltamivir carboxylate concentrations in plasma and urine were determined using liquid chromatography–tandem mass spectrometry. Results: Area under the plasma concentration–time curve (AUC of oseltamivir and oseltamivir carboxylate decreased after dexamethasone treatment for 6 days. The geometric mean ratio (90% confidence interval of the metabolic ratio

  19. Effects of tai chi qigong on psychosocial well-being among hidden elderly, using elderly neighborhood volunteer approach: a pilot randomized controlled trial

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    Chan AW

    2017-01-01

    Full Text Available Aileen WK Chan, Doris SF Yu, KC Choi The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR Purpose: To test the feasibility and preliminary effectiveness of a tai chi qigong program with the assistance of elderly neighborhood volunteers in strengthening social networks and enhancing the psychosocial well-being of hidden elderly. Patients and methods: “Hidden elderly” is a term used to describe older adults who are socially isolated and refuse social participation. This pilot randomized controlled trial recruited 48 older adults aged 60 or above who did not engage in any social activity. They were randomized into tai chi qigong (n=24 and standard care control (n=24 groups. The former group underwent a three-month program of two 60-minute sessions each week, with the socially active volunteers paired up with them during practice. Standard care included regular home visits by social workers. Primary outcomes were assessed by means of the Lubben social network and De Jong Gieveld loneliness scales, and by a revised social support questionnaire. Secondary outcomes were covered by a mental health inventory and the Rosenberg self-esteem scale, and quality of life by using the 12-Item Short Form Health Survey. Data was collected at baseline, and at three and six months thereafter. Results: The generalized estimating equations model revealed general improvement in outcomes among participants on the tai chi qigong program. In particular, participants reported a significantly greater improvement on the loneliness scale (B=-1.32, 95% confidence interval [CI] -2.54 to -0.11, P=0.033 and the satisfaction component of the social support questionnaire (B=3.43, 95% CI 0.10–6.76, P=0.044 than the control group. Conclusion: The pilot study confirmed that tai chi qigong with elderly neighborhood volunteers is a safe and feasible social intervention for hidden elderly. Its potential benefits in

  20. A Pilot Study of Biomedical Text Comprehension using an Attention-Based Deep Neural Reader: Design and Experimental Analysis.

    Science.gov (United States)

    Kim, Seongsoon; Park, Donghyeon; Choi, Yonghwa; Lee, Kyubum; Kim, Byounggun; Jeon, Minji; Kim, Jihye; Tan, Aik Choon; Kang, Jaewoo

    2018-01-05

    Sentence (BMKC_LS) (together referred to as BioMedical Knowledge Comprehension) using the PubMed corpus. The experimental results showed that the performance of our model is much higher than that of humans. We observed that our model performed consistently better regardless of the degree of difficulty of a text, whereas humans have difficulty when performing biomedical literature comprehension tasks that require expert level knowledge. ©Seongsoon Kim, Donghyeon Park, Yonghwa Choi, Kyubum Lee, Byounggun Kim, Minji Jeon, Jihye Kim, Aik Choon Tan, Jaewoo Kang. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 05.01.2018.

  1. Survey of the use of warfarin and the newer anticoagulant dabigatran in patients with atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Choi JC

    2014-02-01

    Full Text Available Jiyoon C Choi,1 Marco d DiBonaventura,2 Lewis Kopenhafer,2 Winnie W Nelson31LifeScan, Inc, West Chester, PA, 2Health Sciences Practice, Kantar Health, New York, NY, 3Janssen Scientific Affairs LLC, Raritan, NJ, USABackground: Oral dabigatran was recently approved as an alternative to warfarin for prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Unlike warfarin, dabigatran has a fixed dosage and few drug interactions, and does not require anticoagulation monitoring or dietary restrictions.Methods: This study aimed to describe and compare characteristics of patients with atrial fibrillation who used dabigatran or only warfarin. Patients with a self-reported diagnosis of atrial fibrillation aged ≥18 years who were receiving (or had received warfarin or dabigatran completed an online survey. Differences in characteristics of dabigatran and warfarin users were tested using chi-squared tests and analysis of variance for categorical and continuous variables, respectively.Results: Overall, 364 patients were surveyed (204 warfarin users, 160 dabigatran users. The mean age was 65.1 years, and 68.7% were male. Dabigatran users were more likely than warfarin users to be female (36.9% versus 27.0% and to have experienced adverse events, including gastrointestinal bleeding, in the 3 months before the survey (21.9% versus 6.9%; P<0.05. Both groups reported high medication adherence (dabigatran users 0.65 versus warfarin users 0.63 missed doses/month. Dabigatran users were more likely than warfarin users to discuss treatment options with their physician before beginning therapy (36.9% versus 24.5%; P<0.05 and less likely to switch anticoagulant medication (10.7% versus 31.9%; P<0.05. Although dabigatran users were more likely to experience adverse events, they reported greater satisfaction with anticoagulation treatment than warfarin users.Conclusion: The efficacy and convenience reported by dabigatran users

  2. Failed vascularized proximal fibular epiphyseal transfer for hip reconstruction following infection in children.

    Science.gov (United States)

    Debarge, Romain; Chotel, Franck; Gazarian, Aram; Viola, Jérémy; Berard, Jérôme

    2009-08-01

    Treatment of the sequellae of hip infection with epiphyseal destruction in children has had limited success to date. The aim of this study was to report mid-term results after hip epiphyseal reconstruction using a proximal vascularized fibular graft in three children presenting with massive epiphyseal destruction of the proximal femur following infection. Three children suffered from hip articular destruction type IVB according to the Choi classification after neonatal septic arthritis. The mean age at reconstruction was 4.3 years (range 3-6 years). The Hunka et al. criteria were used to evaluate the functional results, and the clinical evaluation was based on the Musculo-Skeletal Tumor Society (MSTS) score. Growth and fusion of the graft and hip morphology were evaluated on simple X-rays and by magnetic resonance imaging (MRI). A ratio between cephalic diameter and inter-acetabular gap was defined on the MRI scan as the "acetabular filling index". No intraoperative complication was reported. With a mean follow-up of 4.8 years (3-6 years), the MSTS score was 22.7/30 (range 20-26), while the average lower limb length discrepancy was 3 cm. Patient 1 required a secondary derotation osteotomy of the femur because of abnormal external rotation and a bad result due to the unexplained occurrence of a painful and stiff hip joint. A secondary distal transfer of the greater trochanter was performed in patient 2, and good results based on Hunka et al.'s criteria were achieved. The X-rays of patients 1 and 2 showed signs of bone growth and a major remodeling process; the MRI filling indices were 83 and 67%, respectively. Patient 3 developed an early slipped capital (fibular) epiphysis 1 month postoperatively, which was treated by percutaneous pinning; this early complication led to a bad result with full resorption of the graft. In contrast to its success in upper limb reconstruction, in this series of three patients with hip articular destruction, articular reconstruction

  3. Pharmacokinetic interaction between udenafil and dapoxetine: a randomized, open-labeled crossover study in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kim YH

    2015-02-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Shi Hyang Lee,1 Hae Sun Jeon,1 Hyeong-Seok Lim,1 Mi Young Bahng,2 Kyun-Seop Bae1 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, College of Medicine, University of Ulsan, 2Clinical Development Department, Dong-A ST Co, Ltd, Seoul, Republic of Korea Background: “Udenafil” is a phosphodiesterase-5 inhibitor indicated for erectile dysfunction. “Dapoxetine” is a serotonin transport inhibitor indicated for premature ejaculation. The aim of the study reported here was to investigate the pharmacokinetic drug interaction between udenafil and dapoxetine in healthy male subjects. Methods: An open-label, three-treatment, six-sequence, three-period crossover study was performed in healthy male subjects. In varying sequences, each subjects received single oral doses of udenafil 200 mg, dapoxetine 60 mg, and both treatments. The periods were separated by a washout period of 7 days. Serial blood samples were collected up to 48 hours after dosing. The plasma concentrations of udenafil and dapoxetine were determined using a validated liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were obtained by non-compartmental analysis. Tolerability was assessed throughout the study. Results: Twenty-three healthy subjects completed the study. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for udenafil were 0.923 (90% confidence interval [CI]: 0.863–0.987 and 0.864 (90% CI: 0.789–0.947, respectively. The geometric mean ratios of the area under the plasma concentration–time curve from time 0 to last measurable time point and measured peak plasma concentration for dapoxetine were 1.125 (90% CI: 1.044–1.213 and 0.837 (90% CI: 0.758–0.925, respectively. There were no serious adverse events reported, and none of the subjects dropped out due to adverse events

  4. Operator-sum representation for bosonic Gaussian channels

    International Nuclear Information System (INIS)

    Ivan, J. Solomon; Sabapathy, Krishna Kumar; Simon, R.

    2011-01-01

    extremality in terms of Kraus operators, originally due to Choi, is employed to show that all quantum-limited Gaussian channels are extremal. The fact that almost every noisy Gaussian channel can be realized as a product of a pair of quantum-limited channels is used to construct a discrete set of linearly independent Kraus operators for these noisy Gaussian channels, including the classical noise channel, and these Kraus operators have a particularly simple structure.

  5. Relação entre Valor de Mercado e Ativo Intangível na Bovespa.

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-09-01

    Full Text Available O valor de mercado das ações das empresas, negociados em bolsa, deve traduzir as expectativas dos investidores. E, muito embora os preços dessas ações estejam sujeitos à lei da oferta e da procura, diferentes métodos de avaliação, que utilizam diferentes indicadores contábeis, dados econômicos e interpretações subjetivas, podem gerar desvios no valor percebido das empresas. Este valor de mercado organizacional é conhecido como o preço da ação multiplicado pelo número das ações presentes para negociação. Esta equidade é uma questão de interesse para gestores contábeis, políticos e investigadores (Choi, 2000. É buscar a predição dos valores de mercado de empresas abertas, a partir das expectativas de valorização por parte dos acionistas. Para tanto é necessário entender a relação existente entre o retorno do ativo intangível e o retorno do valor de mercado das empresas da amostra, utilizada nos últimos cinco períodos, sendo esse o objetivo principal do trabalho. Este trabalho se enquadra numa pesquisa analítica, indutiva e básica (Collis; Hussey, 2005. Compreende uma pesquisa qualitativo-quantitativa na área de administração, finanças coorporativas e mercado financeiro brasileiro (Cherobim, 2003. Assim, responde-se à pergunta de pesquisa com algumas técnicas estatísticas, uma vez que o artigo não abrange todas as possibilidades de relações existentes entre as duas variáveis de forma estatística, mas tem forte capacidade de indicar a não predição do valor de mercado pelos ativos incorpóreos organizacionais. Palavras-chave:   Ativos

  6. Alzheimer's Disease in Social Media: Content Analysis of YouTube Videos.

    Science.gov (United States)

    Tang, Weizhou; Olscamp, Kate; Choi, Seul Ki; Friedman, Daniela B

    2017-10-19

    and viewers' interests. YouTube videos on AD could be beneficial if the messages delivered meet users' needs and provide mobilizing information for further resources. Study findings will be useful to government agencies, researchers, nonprofit organizations that promote information about AD, and those responsible for social media to provide useful and accurate health information for the public. ©Weizhou Tang, Kate Olscamp, Seul Ki Choi, Daniela B Friedman. Originally published in the Interactive Journal of Medical Research (http://www.i-jmr.org/), 19.10.2017.

  7. Comparative pharmacokinetics of a fixed-dose combination vs concomitant administration of telmisartan and S-amlodipine in healthy adult volunteers

    Directory of Open Access Journals (Sweden)

    Oh M

    2017-12-01

    Full Text Available Minkyung Oh,1,2,* Sung-Eun Park,3,* Jong-Lyul Ghim,1–3 Young-Kyung Choi,1 Eon-Jeong Shim,1–3 Jae-Gook Shin,1–3 Eun-Young Kim1–3 1Department of Pharmacology, 2PharmacoGenomics Research Center, Inje University College of Medicine, Busan, 3Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, Republic of Korea *These authors contributed equally to this work Objective: This study compared the pharmacokinetic (PK and safety profiles of a fixed-dose combination (FDC formulation of telmisartan and S-amlodipine with those of concomitant administration of the two drugs.Materials and methods: This was an open-label, randomized, crossover study in healthy male Koreans. All subjects were administered an FDC tablet containing 40 mg telmisartan and 5 mg S-amlodipine and were also coadministered the same dose of both drugs given separately. The crossover study design included a 14-day washout period between the two treatments. Blood samples were collected up to 168 h following drug administration. The plasma concentrations of telmisartan and S-amlodipine were determined by liquid chromatography tandem mass spectrometry. PK parameters and plasma concentration–time curves were compared. Safety was assessed by measuring vital signs, clinical laboratory tests, physical examinations, and patient interviews.Results: The geometric mean ratios and 90% CIs for the maximum plasma concentration (Cmax and area under the curve from time zero to the last sampling time (AUCt were 0.8782 (0.8167–0.9444 and 0.9662 (0.9210–1.0136 for telmisartan and 1.0069 (0.9723–1.0427 and 1.0324 (0.9969–1.0690 for S-amlodipine, respectively. A total of 36 adverse events (AEs were reported by 23 subjects, but no statistical differences were observed between the two treatments. The most frequently reported AE was a mild-to-moderate headache that was generally self-limiting.Conclusion: For both telmisartan and S-amlodipine, the Cmax and AUCt 90% CIs

  8. Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

    Directory of Open Access Journals (Sweden)

    Han JW

    2017-10-01

    Full Text Available Jae Woong Han, Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC, Konkuk University, Seoul, Republic of Korea Background: Silver nanoparticles (AgNPs exhibit strong antibacterial and anticancer activity owing to their large surface-to-volume ratios and crystallographic surface structure. Owing to their various applications, understanding the mechanisms of action, biological interactions, potential toxicity, and beneficial effects of AgNPs is important. Here, we investigated the toxicity and differentiation-inducing effects of AgNPs in teratocarcinoma stem cells. Materials and methods: AgNPs were synthesized and characterized using various analytical techniques such as UV–visible spectroscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and transmission electron microscopy. The cellular responses of AgNPs were analyzed by a series of cellular and biochemical assays. Gene and protein expressions were analyzed by reverse transcription-quantitative polymerase chain reaction and western blotting, respectively. Results: The AgNPs showed typical crystalline structures and spherical shapes (average size =20 nm. High concentration of AgNPs induced cytotoxicity in a dose-dependent manner by increasing lactate dehydrogenase leakage and reactive oxygen species. Furthermore, AgNPs caused mitochondrial dysfunction, DNA fragmentation, increased expression of apoptotic genes, and decreased expression of antiapoptotic genes. Lower concentrations of AgNPs induced neuronal differentiation by increasing the expression of differentiation markers and decreasing the expression of stem cell markers. Cisplatin reduced the viability of F9 cells that underwent AgNPs-induced differentiation. Conclusion: The results showed that AgNPs caused differentially regulated cytotoxicity and induced neuronal differentiation of F9 cells in a concentration-dependent manner

  9. Hot-water extract of the branches of Hovenia dulcis Thunb. (Rhamnaceae ameliorates low-fiber diet-induced constipation in rats

    Directory of Open Access Journals (Sweden)

    Choi CY

    2018-04-01

    Full Text Available Chul-Yung Choi,1 Seung-Sik Cho,2 In-Soo Yoon3 1Department of Natural Medicine Research, Jeonnam Institute of Natural Resources Research, Jangheung-gun, 2Department of Pharmacy, College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam, 3Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Geumjeong-gu, Busan, South Korea Abstract: Hovenia dulcis Thunb. (Rhamnaceae, also known as oriental raisin tree, is used in traditional herbal medicine. Its extracts have been reported to show various pharmacological effects such as hepatoprotection, antitumor, antiatopic dermatitis, antilipid peroxidation, antisteatotic, anti-inflammatory, and antiallergic activities. However, there have been no reports on the effect of H. dulcis extracts in relieving constipation so far. The aim of this study was to investigate the effects of a hot-water extract of the branches of H. dulcis (WEHD on low-fiber diet-induced constipation in Sprague Dawley rats. The in vivo laxative activity of WEHD was assessed by measuring the intestinal transit of charcoal meal and stool parameters. Furthermore, the in vitro spasmogenic activity of WEHD was evaluated by monitoring the temporal profiles of contraction of rat colon in the absence or presence of WEHD. In addition, constituent profiling was conducted using high-performance liquid chromatography analysis. Pretreatment with WEHD significantly enhanced the intestinal transit of charcoal meal and increased the frequency and weight of stools in rats. In addition, the frequency and amplitude of contractile responses of isolated rat colon were markedly enhanced by WEHD. Two organic phenolic acids, ferulic and vanillic acids, were identified in WEHD, of which vanillic acid exhibited spasmogenic activity. To the best of our knowledge, this is the first study to report the laxative and spasmogenic activities of H. dulcis and its constituents, suggesting that

  10. Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

    Directory of Open Access Journals (Sweden)

    Naeem M

    2015-07-01

    Full Text Available Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, Yangsan, South KoreaAbstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs for the treatment of colitis. Eudragit FS30D was used as a pH-dependent polymer, and Eudragit RS100 as a time-dependent controlled release polymer. Single pH-dependent NPs (pH_NPs, single time-dependent NPs (Time_NPs, and dual pH/time-dependent NPs (pH/Time_NPs were prepared using the oil-in-water emulsion method. The physicochemical properties and drug release profiles of these NPs in gastrointestinal (GI tract conditions were investigated. The therapeutic potential and in vivo distribution of the NPs were evaluated in a dextran sulfate sodium (DSS-induced colitis mice model. The pH/Time_NPs prevented a burst drug release in acidic pH conditions and showed sustained release at a colonic pH. The in vivo distribution study in the mice GI tract demonstrated that pH/Time_NPs were more efficiently delivered to the inflamed colon than pH_NPs were. Compared to the single pH_NPs-treated group, the pH/Time_NPs-treated group showed increased body weight and colon length and markedly decreased disease activity index, colon weight/length ratios, histological damage, and inflammatory cell infiltration in colon tissue. Our results demonstrate that the dual pH/time-dependent NPs are an effective oral colon-targeted delivery system for colitis therapy.Keywords: colon-specific delivery, dual-sensitive delivery

  11. Perceptions of a HIV testing message targeted for at-risk adults with low functional health literacy

    Science.gov (United States)

    Hunter, Susan L.

    This study analyses warehoused data collected by Georgia State University and Centers for Disease Control and Prevention (GSU/CDC) researchers after developing an HIV testing message for urban adults with low functional health literacy. It expands previous work by examining data collected when 202 primarily African-American homeless clients of an urban community based organization (CBO) reviewed both the low literacy brochure (Wallace et al., 2006) and a standard HIV brochure (Georgia Department of Human Resources, 1997). Participants' health literacy was assessed using 2 measures; the Rapid Estimate of Adult Literacy in Medicine or REALM (Davis, Crouch, Long & Green) and the Test of Functional Health Literacy Assessment or TOFHLA (Nurss, Parker & Baker, 2001). HIV risk was determined using an interview questionnaire developed by the research group (Belcher, Deming, Hunter & Wallace, 2005) which allowed participants to self-report recent alcohol and drug use, sexual behavior, sexually transmitted disease (STD) history and exposure to abuse and sexual coercion. Open-ended response questions regarding readability, understanding, main message, and importance for each brochure provided the qualitative data. This analysis confirms previous work showing accessibility, readability, cultural sensitivity and user-friendly formatting are important when attempting to engage at-risk adults with varying levels of functional health literacy in an HIV testing message. The visual aspects of the brochure can be essential in capturing the reader's attention and should be relevant to the target audience (Wallace, Deming, Hunter, Belcher & Choi, 2006). Mono-colored graphics may be perceived as dated and irrelevant or worse yet, threatening to some readers. Whenever possible culturally appropriate color photos of people depicting relevant content should replace excess text and difficult medical terms should be eliminated. Wording on the cover and within the brochure should be used to

  12. Citations Prize 2009 Citations Prize 2009

    Science.gov (United States)

    Webb, Steve; Harris, Simon

    2009-12-01

    Physics in Medicine & Biology (PMB) awards its 'Citations Prize' to the authors of the original research paper that has received the most citations in the preceding five years (according to the Institute for Scientific Information (ISI)). The lead author of the winning paper is presented with the Rotblat Medal (named in honour of Professor Sir Joseph Rotblat who was the second—and longest serving—Editor of PMB, from 1961-1972). The winning co-authors each receive a certificate. Photograph of the 2009 Citations Prize winners Some of the winning authors with their certificates, and Christian Morel with the Rotblat Medal, at the award ceremony in Orsay, near Paris. From left to right are Corinne Groiselle, Lydia Maigne, David Brasse, Irène Buvat, Dimitris Visvikis, Giovanni Santin, Uwe Pietrzyk, Pierre-François Honore, Christian Morel, Sébastien Jan and Arion Chatziioannou. The winner of the 2009 Citations Prize for the paper which has received the most citations in the previous 5 years (2004-2008) is GATE: a simulation toolkit for PET and SPECT Authors: S Jan, G Santin, D Strul, S Staelens, K Assié, D Autret, S Avner, R Barbier, M Bardiès, P M Bloomfield, D Brasse, V Breton, P Bruyndonckx, I Buvat, A F Chatziioannou, Y Choi, Y H Chung, C Comtat, D Donnarieix, L Ferrer, S J Glick, C J Groiselle, D Guez, P-F Honore, S Kerhoas-Cavata, A S Kirov, V Kohli, M Koole, M Krieguer, D J van der Laan, F Lamare, G Largeron, C Lartizien, D Lazaro, M C Maas, L Maigne, F Mayet, F Melot, C Merheb, E Pennacchio, J Perez, U Pietrzyk, F R Rannou, M Rey, D R Schaart, C R Schmidtlein, L~Simon, T Y Song, J-M Vieira, D Visvikis, R Van de Walle, E Wieörs and C Morel Reference: S Jan et al 2004 Phys. Med. Biol. 49 4543-61 Since its publication in 2004 this article has received over 200 citations. This extremely high figure is a testament to the great influence and usefulness of the work to the nuclear medicine community. More discussion of the winning paper can be found on

  13. Schisandrae fructus enhances myogenic differentiation and inhibits atrophy through protein synthesis in human myotubes

    Directory of Open Access Journals (Sweden)

    Kim CH

    2016-05-01

    Full Text Available Cy Hyun Kim,1,2,* Jin-Hong Shin,1,3,* Sung Jun Hwang,1,2 Yung Hyun Choi,4 Dae-Seong Kim,1,3 Cheol Min Kim2,51Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 2Center for Anti-Aging Industry, Pusan National University, Busan, 3Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, 4Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan, 5Department of Biomedical Informatics, Pusan National University School of Medicine, Yangsan, Republic of Korea*These authors contributed equally to this work Abstract: Schisandrae fructus (SF has recently been reported to increase skeletal muscle mass and inhibit atrophy in mice. We investigated the effect of SF extract on human myotube differentiation and its acting pathway. Various concentrations (0.1–10 µg/mL of SF extract were applied on human skeletal muscle cells in vitro. Myotube area and fusion index were measured to quantify myotube differentiation. The maximum effect was observed at 0.5 µg/mL of SF extract, enhancing differentiation up to 1.4-fold in fusion index and 1.6-fold in myotube area at 8 days after induction of differentiation compared to control. Phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 and 70 kDa ribosomal protein S6 kinase, which initiate translation as downstream of mammalian target of rapamycin pathway, was upregulated in early phases of differentiation after SF treatment. SF also attenuated dexamethasone-induced atrophy. In conclusion, we show that SF augments myogenic differentiation and attenuates atrophy by increasing protein synthesis through mammalian target of rapamycin/70 kDa ribosomal protein S6 kinase and eukaryotic translation initiation factor 4E-binding protein 1 signaling pathway in human myotubes. SF can be a useful natural dietary supplement in increasing skeletal muscle mass, especially in the aged

  14. Regarding the influence of sex and aging on dry eye disease

    Directory of Open Access Journals (Sweden)

    Han SB

    2017-09-01

    Full Text Available Sang Beom HanDepartment of Ophthalmology, Kangwon National University Hospital, Kangwon National University Graduate School of Medicine, Chuncheon, Republic of KoreaI read with great interest the article by Ahn et al1 entitled “Sex differences in the effect of aging on dry eye disease”, in which the authors revealed the sex differences in the effect of aging on dry eye disease (DED in Korean adult population. They also showed the differences in patterns of DED following ocular surgery according to sex.1 The large population-based cross-sectional study was undoubtfully well designed and conducted, and suggests that matching of age and sex is recommended in further researches on DED.1However, I would like to point out that there exist controversies regarding the effect of aging and sex on DED. Our previous study showed that age had no significant association with the prevalence of DED in adults of 65 years or older, while female sex was significantly related to increased prevalence of DED.2 By contrast, studies in the US demonstrated that prevalence of DED increased with aging both in male and female populations.3,4 Moreover, there are differences in pathophysiology of DED according to age. Although dysfunction of lacrimal and meibomian glands may play an important role in the pathogenesis of DED in the elderly, DED associated with visual display terminal use or contact lens wear is more common in young and middle-aged patients.5 Therefore, I believe these differences in the pathogenesis should be considered in the evaluation of the effects of sex and aging on DED.Authors' replyJong Ho Ahn,1 Yoon-Hyeong Choi,2 Hae Jung Paik,1 Mee Kum Kim,3 Won Ryang Wee,3 Dong Hyun Kim11Department of Ophthalmology, Gachon University Gil Medical Center, 2Department of Preventive Medicine, Gachon University College of Medicine, Incheon, 3Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South KoreaWe thank the author for taking a

  15. Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic

    Directory of Open Access Journals (Sweden)

    An S

    2013-02-01

    Full Text Available Songhie An,* Kihoon Nam,* Sunghyun Choi, Cheng Z Bai, Yan Lee, Jong-Sang ParkDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea*These authors contributed equally to this workBackground: Glioma is still one of the most complicated forms of brain tumor to remove completely due to its location and the lack of an efficient means to specifically eliminate tumor cells. For these reasons, this study has examined the effectiveness of a nonviral gene therapy approach utilizing a tumor-selective killer gene on a brain tumor xenograft model.Methods and results: The therapeutic apoptin gene was recombined into the JDK plasmid and delivered into human brain tumor cells (U87MG by using a polyamidoamine dendrimer with an arginine surface (PAM-RG4. Studies in vitro showed that the PAM-RG4/apoptin plasmid polyplex exhibited a particularly high transfection activity of >40%. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assay, 4´,6-Diamidino-2-phenylindole (DAPI TUNEL assay, DAPI staining, and caspase-3 activity assay verified that the tumor cells had undergone apoptosis induced by apoptin. For in vivo studies, the polyplex was injected into tumors, which were induced by injecting U87MG cells intradermally into nude mice. Based on hematoxylin and eosin staining, epidermal growth factor receptor immunohistochemistry results and tumor volume measurement results, tumor growth was effectively inhibited and no specific edema, irritation, or other harm to the skin was observed after polyplex injection. The in vivo expression of apoptin and the induction of apoptosis were verified by reverse-transcription polymerase chain reaction analysis, TUNEL assay, and DAPI staining.Conclusion: The PAM-RG4/apoptin gene polyplex is a strong candidate for brain tumor therapeutics because of the synergistic effect of the carrier's high transfection efficiency (35%–40% in glioma cells and the selective apoptosis-inducing activity of

  16. Toward Predicting Social Support Needs in Online Health Social Networks.

    Science.gov (United States)

    Choi, Min-Je; Kim, Sung-Hee; Lee, Sukwon; Kwon, Bum Chul; Yi, Ji Soo; Choo, Jaegul; Huh, Jina

    2017-08-02

    data to evaluate the feasibility of the framework. Our study contributes to providing personalized social support in OHSNs. ©Min-Je Choi, Sung-Hee Kim, Sukwon Lee, Bum Chul Kwon, Ji Soo Yi, Jaegul Choo, Jina Huh. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 02.08.2017.

  17. Relação entre Valor de Mercado e Ativo Intangível na Bovespa

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-07-01

    Full Text Available O valor de mercado das ações das empresas, negociados em bolsa, deve traduzir as expectativas dos investidores. E, muito embora os preços dessas ações estejam sujeitos à lei da oferta e da procura, diferentes métodos de avaliação, que utilizam diferentes indicadores contábeis, dados econômicos e interpretações subjetivas, podem gerar desvios no valor percebido das empresas. Este valor de mercado organizacional é conhecido como o preço da ação multiplicado pelo número das ações presentes para negociação. Esta equidade é uma questão de interesse para gestores contábeis, políticos e investigadores (Choi, 2000. É buscar a predição dos valores de mercado de empresas abertas, a partir das expectativas de valorização por parte dos acionistas. Para tanto é necessário entender a relação existente entre o retorno do ativo intangível e o retorno do valor de mercado das empresas da amostra, utilizada nos últimos cinco períodos, sendo esse o objetivo principal do trabalho. Este trabalho se enquadra numa pesquisa analítica, indutiva e básica (Collis; Hussey, 2005. Compreende uma pesquisa qualitativo-quantitativa na área de administração, finanças coorporativas e mercado financeiro brasileiro (Cherobim, 2003. Assim, responde-se à pergunta de pesquisa com algumas técnicas estatísticas, uma vez que o artigo não abrange todas as possibilidades de relações existentes entre as duas variáveis de forma estatística, mas tem forte capacidade de indicar a não predição do valor de mercado pelos ativos incorpóreos organizacionais.

  18. COMPARISON OF ROCURONIUM BROMIDE AND SUCCINYLCHOLINE CHLORIDE FOR USE DURING RAPID SEQUENCE INTUBATION IN ADULTS

    Directory of Open Access Journals (Sweden)

    Ch. Penchalaiah

    2015-08-01

    Full Text Available BACKGROUND AND OBJECTIVE : The goal of rapid sequence intubation is to secure the patients airway smoothly and quickly, minimizing the chances of regurgitation and aspiration of gastric contents. Traditionally succinylcholine chloride has been the neuromuscular blocking drug of choi ce for use in rapid sequence intubation because of its rapid onset of action and profound relaxation. Succinylcholine chloride remains unsurpassed in providing ideal intubating conditions. However the use of succinylcholine chloride is associated with many side effects like muscle pain, bradycardia, hyperkalaemia and rise in intragastric and intraocular pressure. Rocuronium bromide is the only drug currently available which has the rapidity of onset of action like succinylcholine chloride. Hence the present study was undertaken to compare rocuronium bromide with succinylcholine chloride for use during rapid sequence intubation in adult patients. METHODOLOGY : The study population consisted of 90 patients aged between 18 - 60 years posted for various elective su rgeries requiring general anaesthesia . S tudy population was randomly divided into 3 groups with 30 patients in each sub group. 1. Group I : Intubated with 1 mg kg - 1 of succinylcholine chloride (n=30 . 2. Grou p II : Intubated with rocuronium bromide 0.6 mg kg - 1 (n=30 . 3. Group III : Intubated with rocuronium bromide 0.9 mg kg - 1 (n=30 . Intubating conditions were assessed at 60 seconds based on the scale adopted by Toni Magorian et al. 1993. The haemodynamic para meters in the present study were compared using p - value obtained from student t - test . RESULTS : It was noted that succinylcholine chloride 1 mg kg - 1 body weight produced excellent intubating conditions in all patients. Rocuronium bromide 0.6 mg kg - 1 body we ight produced excellent intubating conditions in 53.33% of patients but produced good to excellent intubating conditions in 96.67% of patients. Rocuronium bromide 0.9 mg kg - 1

  19. Turbulence characteristics of the Bödewadt layer in a large enclosed rotor-stator system

    Science.gov (United States)

    Randriamampianina, Anthony; Poncet, Sébastien

    2006-05-01

    A three-dimensional (3D) direct numerical simulation is combined with a laboratory study to describe the turbulent flow in an enclosed annular rotor-stator cavity characterized by a large aspect ratio G =(b-a)/h=18.32 and a small radius ratio a /b=0.152, where a and b are the inner and outer radii of the rotating disk and h is the interdisk spacing. The rotation rate Ω under consideration is equivalent to the rotational Reynolds number Re =Ωb2/ν=9.5×104, where ν is the kinematic viscosity of the fluid. This corresponds to a value at which an experiment carried out at the laboratory has shown that the stator boundary layer is turbulent, whereas the rotor boundary layer is still laminar. Comparisons of the 3D computed solution with velocity measurements have given good agreement for the mean and turbulent fields. The results enhance evidence of weak turbulence at this Reynolds number, by comparing the turbulence properties with available data in the literature [M. Lygren and H. I. Andersson, J. Fluid Mech. 426, 297 (2001)]. An approximately self-similar boundary layer behavior is observed along the stator side. The reduction of the structural parameter a1 under the typical value 0.15 and the variation in the wall-normal direction of the different characteristic angles show that this boundary layer is three-dimensional. A quadrant analysis [H. S. Kang, H. Choi, and J. Y. Yoo, Phys. Fluids 10, 2315 (1998)] of conditionally averaged velocities is performed to identify the contributions of different events (ejections and sweeps) on the Reynolds shear stress producing vortical structures. The asymmetries observed in the conditionally averaged quadrant analysis are dominated by Reynolds stress-producing events in this Bödewadt layer. Moreover, case 1 vortices (with a positive wall induced velocity) are found to be the major source of generation of special strong events, in agreement with the conclusions of Lygren and Andersson [J. Fluid Mech. 426, 297 (2001)].

  20. Optimization and physicochemical characterization of a cationic lipid-phosphatidylcholine mixed emulsion formulated as a highly efficient vehicle that facilitates adenoviral gene transfer

    Directory of Open Access Journals (Sweden)

    Kim SY

    2017-10-01

    Full Text Available Soo-Yeon Kim,1,2 Sang-Jin Lee,2 Jin-Ki Kim,3 Han-Gon Choi,3 Soo-Jeong Lim1 1Department of Bioscience and Bioengineering, Sejong University, Seoul, Kwangjin-gu, Seoul, 2Immunotherapeutics Branch, Research Institute, National Cancer Center, Ilsandong-gu, Goyang-si, Gyeonggi-do, 3College of Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Sangnok-gu, Ansan, Republic of Korea Abstract: Cationic lipid-based nanoparticles enhance viral gene transfer by forming electrostatic complexes with adenoviral vectors. We recently demonstrated the superior complexation capabilities of 1,2-dioleoyl-3-trimethylammonium propane (DOTAP emulsion compared with a liposomal counterpart but the cytotoxicity of DOTAP emulsions remained a challenge. The present study is aimed at formulating an emulsion capable of acting as a highly effective viral gene transfer vehicle with reduced cytotoxicity and to physicochemically characterize the structures of virus-emulsion complexes in comparison with virus–liposome complexes when the only difference between emulsions and liposomes was the presence or absence of inner oil core. The emulsion formulation was performed by 1 reducing the content of DOTAP while increasing the content of zwitterionic lipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, and 2 optimizing the oil content. The complexation capability of formulated DOTAP:DMPC mixed emulsions was similar to those of emulsions containing DOTAP alone while displaying significantly lower cytotoxicity. The complexation capabilities of the DOTAP:DMPC mixed emulsion were serum-compatible and were monitored in a variety of cell types, whereas its liposomal counterpart was totally ineffective. Characterization by scanning electron microscopy, transmission electron microscopy, atomic force microscopy, and dynamic light scattering studies indicated that the optimized emulsions spontaneously surrounded the virus particles to generate emulsions that

  1. Measurement of the Thermal Conductivity of Nano-fluid for the advanced heat exchanger

    International Nuclear Information System (INIS)

    Yoo, Shin; Lee, Jae Young

    2006-01-01

    The enhancement of heat transfer has been widely investigated to provide an effective way to cool down the modern electronic devices. Among the methods, Choi discovered a large amount of increase of thermal conductivity when nano sized particles were suspended in the fluid. It was first introduced by Masuda as a potential heat transfer enhancement media and since then, many researchers have investigated the nanofluids phenomena. Many researchers reported in substantially increasing the thermal conductivity of fluids by adding small amounts of suspended metallic oxide nanoparticles of Cu, CuO, Al 2 O 3 and carbon nano-tube. Masuda reported that the use Al 2 O 3 particles of 13 nm at 4.3% volume fraction increased the thermal conductivity of water by 30%. For carbon nano-tube nanofluids shows even greater enhancement. Xie et al. measured the thermal conductivity of carbon nanotube suspended in organic liquid and water with the enhancement of 10-20%. Recent studies have shown that inserting just 1% concentration of nano-particles sometimes increases about maximum 40% of thermal conductivity. However, there is still few experiments done for TiO 2 nanoparticles. Murshed found that the enhancement of thermal conductivity shows about 30% with 15nm in diameter with maximum 5% volume fraction and about 40% enhancement is observed using 15nmD x 40nm rod-shape nanoparticles of TiO 2 . The present experimental shows that a 20% maximum of enhancement in thermal conductivity using TiO 2 of 10nm for 3% volume fraction. Theses results are compared with previous research with theoretical models. As the first step of the heat transfer of nano fluid, the theories related to the nanofluids investigations have been discussed to understand not only the mechanism of thermal conductivity measurement, but also to understand the nanofluid behavior. Colloidal stability is the key to the nanofluid considered to prevent the agglomeration. Through the results, we will discuss the importance of

  2. Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

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    Kim CO

    2016-11-01

    Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, 3Chong Kun Dang Clinical Research, Chong Kun Dang Pharmaceutical Corp., 4Chong Kun Dang Research Institute, Chong Kun Dang Pharmaceutical Corp., 5Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea Abstract: CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg and randomized to CKD-519 (n=6 or matching placebo (n=2. CKD-519 reached the maximum plasma concentration (Cmax at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC and Cmax increased with the dose, however, Cmax and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83% was observed at 6–8 h post-dose. A sigmoid Emax model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC50 of 17.3 ng/mL. Overall, 11 adverse events (AEs were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent

  3. Dose proportionality and pharmacokinetics of carvedilol sustained-release formulation: a single dose-ascending 10-sequence incomplete block study

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    Kim YH

    2015-06-01

    Full Text Available Yo Han Kim,1 Hee Youn Choi,1 Yook-Hwan Noh,1 Shi Hyang Lee,1 Hyeong-Seok Lim,1 Chin Kim,2 Kyun-Seop Bae11Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, 2Chong Kun Dang Clinical Research and Clinical Epidemiology and Medical Information, CKD Pharmaceuticals, Seoul, Republic of KoreaBackground: Carvedilol is a third-generation β-blocker indicated for congestive heart failure and high blood pressure. The aim of this study was to investigate the dose proportionality of the carvedilol sustained-release (SR formulation in healthy male subjects.Methods: An open-label, single dose-ascending, 10-sequence, 3-period balanced incomplete block study was performed using healthy male subjects. In varying sequences, each subject received three of five carvedilol SR formulations (8, 16, 32, 64, or 128 mg once. The treatment periods were separated by a washout period of 7 days. Serial blood samples were collected up to 48 h after dosing. The plasma concentrations of carvedilol were determined by using validated liquid chromatography–tandem mass spectrometry. Pharmacokinetic parameters including the area under the plasma concentration–time curve (AUC from time 0 to the last measurable time (AUClast, AUC extrapolated to infinity (AUCinf, and the measured peak plasma concentration (Cmax were obtained by noncompartmental analysis. Dose proportionality was evaluated if the ln–ln plots of AUClast, AUCinf, and Cmax versus dose were linear and the 90% confidence intervals (CIs of the slopes were within 0.9195 and 1.0805. Tolerability was assessed by vital signs, electrocardiogram, clinical laboratory tests, and monitoring of adverse events (AEs throughout the study.Results: A total of 31 subjects were enrolled, and 30 completed the study. The assessment of dose proportionality meets the statistical criteria; the point estimates of slope were 1.0104 (90% CI: 0.9849–1.0359 for AUClast, 1

  4. Log In to Experiential Learning Theory: Supporting Web-Based Faculty Development.

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    Omer, Selma; Choi, Sunhea; Brien, Sarah; Parry, Marcus

    2017-09-27

    . Grounding Web-based training in learning theory offers an effective and flexible approach for faculty development. ©Selma Omer, Sunhea Choi, Sarah Brien, Marcus Parry. Originally published in JMIR Medical Education (http://mededu.jmir.org), 27.09.2017.

  5. Optimal medical therapy for secondary prevention after an acute coronary syndrome: 18-month follow-up results at a tertiary teaching hospital in South Korea

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    Byeon HJ

    2016-02-01

    Full Text Available Hee Ja Byeon,1,* Young-Mo Yang,2,* Eun Joo Choi21Department of Pharmacy, Chosun University Hospital, 2Department of Pharmacy, College of Pharmacy, Chosun University, Gwangju, South Korea*These authors contributed equally to this workBackground: Acute coronary syndrome (ACS is a fatal cardiovascular disease caused by atherosclerotic plaque erosion or rupture and formation of coronary thrombus. The latest guidelines for ACS recommend the combined drug regimen, comprising aspirin, P2Y12 inhibitor, angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, β-blocker, and statin, at discharge after ACS treatment to reduce recurrent ischemic cardiovascular events. This study aimed to examine prescription patterns of secondary prevention drugs in Korean patients with ACS after hospital discharge, to access the appropriateness of secondary prevention drug therapy for ACS, and to evaluate whether to persistently use discharge medications for 18 months.Methods: This study was retrospectively conducted with the patients who were discharged from the tertiary hospital, located in South Korea, after ACS treatment between September 2009 and August 2013. Data were collected through electronic medical record.Results: Among 3,676 patients during the study period, 494 were selected based on inclusion and exclusion criteria. The regimen of aspirin + clopidogrel + β-blocker + angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker + statin was prescribed to 374 (75.71% patients with ACS at discharge. Specifically, this regimen was used in 177 (69.69% unstable angina patients, 44 (70.97% non-ST-segment elevation myocardial infarction patients, and 153 (85.96% ST-segment elevation myocardial infarction patients. Compared with the number of ACS patients with all five guideline-recommended drugs at discharge, the number of ACS patients using them 12 (n=169, 34.21% and 18 (n=105, 21.26% months after discharge tended to be gradually

  6. Increased fat in pancreas not associated with risk of pancreatitis post-endoscopic retrograde cholangiopancreatography

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    Pokhrel B

    2014-06-01

    Full Text Available Bhupesh Pokhrel,1 Eun Kwang Choi,1 Omer Khalid,2 Kumar Sandrasegaran,3 Evan L Fogel,1 Lee McHenry,1 Stuart Sherman,1 James Watkins,1 Gregory A Cote,1 Henry A Pitt,4 Nicholas J Zyromski,4 Beth Juliar,1 Glen A Lehman11Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 2Department of Gastroenterology, St Louis University School of Medicine, St Louis, MO, 3Department of Radiology, 4Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USABackground: A preliminary study has shown increased pancreatic fat in patients with idiopathic pancreatitis and sphincter of Oddi dysfunction. In this study, we aimed to determine if an increased quantity of pancreatic fat is an independent risk factor for pancreatitis post-endoscopic retrograde cholangiopancreatography (ERCP.Methods: In this case control study, we retrospectively reviewed a local radiological and ERCP database to identify patients who had had abdominal magnetic resonance imaging (MRI followed by ERCP no more than 60 days later between September 2003 and January 2011. Percentage of fat was determined by recording signal intensity in the in-phase (Sin and out-of-phase (Sout T1-weighted gradient sequences, and calculation of the fat fraction as (Sin - Sout/(Sin × 2 by an abdominal radiologist blinded to clinical history. Controls matched for age, gender, and other pancreatobiliary disease were selected from a group with no post-ERCP pancreatitis (before fat content of the pancreas was analyzed.Results: Forty-seven patients were enrolled. Compared with controls, subjects with post-ERCP pancreatitis were similar in terms of age (41.4 years versus 41.1 years, gender (21.2% versus 20.2% males, pancreatobiliary disease characteristics, and most ERCP techniques. Measurements of pancreatic head, body, and tail fat and body mass index were similar in patients and controls.Conclusion: Increased pancreatic fat on MRI criteria is not an independent

  7. Utilization of a Clinical Trial Management System for the Whole Clinical Trial Process as an Integrated Database: System Development.

    Science.gov (United States)

    Park, Yu Rang; Yoon, Young Jo; Koo, HaYeong; Yoo, Soyoung; Choi, Chang-Min; Beck, Sung-Ho; Kim, Tae Won

    2018-04-24

    external users for managing 11,645 studies and 146,943 subjects. The CTMS was introduced in the Asan Medical Center to manage the large amounts of data involved with clinical trial operations. Inter- and intraunit control of data and resources can be easily conducted through the CTMS system. To our knowledge, this is the first CTMS developed in-house at an academic medical center side which can enhance the efficiency of clinical trial management in compliance with privacy and security laws. ©Yu Rang Park, Young Jo Yoon, HaYeong Koo, Soyoung Yoo, Chang-Min Choi, Sung-Ho Beck, Tae Won Kim. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 24.04.2018.

  8. Biodistribution of newly synthesized PHEA-based polymer-coated SPION in Sprague Dawley rats as magnetic resonance contrast agent

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    Park J

    2013-10-01

    Full Text Available Junsung Park,1,2,* Wonkyung Cho,1,2,* Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Dae-Chul Ha,2,5 Youn-Woong Choi,5 Ha-Young Lee,3 Sun-Hang Cho,5 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Biomaterials Laboratory, Korea Research Institutes of Chemical Technology, Daejeon, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea; 5Korea United Pharm Inc, Seoul, Republic of Korea *These authors contributed equally to this work Objectives: The purpose of this study was to observe the pharmacokinetic behavior of newly synthesized biocompatible polymers based on polyhydroxyethylaspartamide (PHEA to be used to coat an iron oxide core to make superparamagnetic iron oxide nanoparticles (SPION. Materials and methods: The isotopes [14C] and [59Fe] were used to label the polymer backbone (CLS and iron oxide core (FLS, respectively. In addition, unradiolabeled cold superparamagnetic iron oxide nanoparticles (SPION/ULS were synthesized to characterize particle size by dynamic light scattering, morphology by transmission electron microscopy, and in vivo magnetic resonance imaging (MRI. CLS and FLS were used separately to investigate the behavior of both the synthesized polymer and [Fe] in Sprague Dawley (SD rats, respectively. Because radioactivity of the isotopes was different by β for CLS and γ for FLS, synthesis of the samples had to be separately prepared. Results: The mean particle size of the ULS was 66.1 nm, and the biodistribution of CLS concentrations in various organs, in rank order of magnitude, was liver > kidney > small intestine > other. The biodistribution of FLS concentrations was liver > spleen > lung > other. These rank orders show that synthesized SPION mainly accumulates in the liver. The differences in the distribution were caused by the SPION metabolism. Radiolabeled

  9. Femtosecond laser writing of new type of waveguides in silver containing glasses (Conference Presentation)

    Science.gov (United States)

    Abou Khalil, Alain; Bérubé, Jean-Philippe; Danto, Sylvain; Desmoulin, Jean-Charles; Cardinal, Thierry; Petit, Yannick G.; Canioni, Lionel; Vallée, Réal

    2017-03-01

    Femtosecond laser writing in glasses is a growing field of research and development in photonics, since it provides a versatile, robust and efficient approach to directly address 3D material structuring. Laser-glass interaction process has been studied for many years, especially the local changes of the refractive index that have been classified by three distinct types (types I, II and III, respectively). These refractive index modifications are widely used for the creation of photonics devices such as waveguides [1], couplers, photonic crystals to fabricate integrated optical functions in glasses for photonic applications as optical circuits or integrated sensors. Femtosecond laser writing in a home-developed silver containing zinc phosphate glasses induces the creation of fluorescent silver clusters distributed around the laser-glass interaction voxel [2]. In this paper, we introduce a new type of refractive index modification in glasses. It is based on the creation of these photo-induced silver clusters allowing a local change in the refractive index Δn = 5×10-3, which is sufficient for the creation of waveguides and photonics devices. The wave guiding process in our glasses along these structures with original geometry is demonstrated for wavelengths from visible to NIR [3], giving a promising access to integrated optical circuits in these silver containing glasses. Moreover, the characterization of the waveguides is presented, including their original geometry, the refractive index change, the mode profile, the estimation of propagation losses and a comparison with simulation results. 1. K. M. Davis, K. Miura, N. Sugimoto, and K. Hirao, Opt. Lett. 21, 1729-1731 (1996). 2. M. Bellec, A. Royon, K. Bourhis, J. Choi, B. Bousquet, M. Treguer, T. Cardinal, J.-J. Videau, M. Richardson, and L. Canioni, The Journal of Physical Chemistry C 114, 15584-15588 (2010). 3. S. Danto, F. Désévédavy, Y. Petit, J.-C. Desmoulin, A. Abou Khalil, C. Strutynski, M. Dussauze, F

  10. Epithelium-on photorefractive intrastromal cross-linking (PiXL for reduction of low myopia

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    Lim WK

    2017-06-01

    Full Text Available Wee Kiak Lim,1,2 Zhi Da Soh,1 Harold Kah Yen Choi,1 Julian Thiam Siew Theng1,3 1Eagle Eye Centre, Mount Alvernia Hospital, 2Department of Ophthalmology, Tan Tock Seng Hospital, 3Department of Ophthalmology, Khoo Teck Puat Hospital, Singapore Purpose: To report the 9–12-month outcomes of a novel procedure for reduction of low myopia through epithelium-on photorefractive intrastromal cross-linking (PiXL with customized control of topographic distribution of ultraviolet (UV-fluence. Method: Myopic patients with normal (non-ectatic corneas underwent the PiXL procedure for reduction of low myopia. PiXL treatments were delivered through selective application of UVA light based on the refractive error of each patient. Clinical evaluation included safety (corrected distance visual acuity, endothelial cell count, central corneal thickness, anterior ocular health and efficacy (uncorrected distance visual acuity, manifest refraction, K-mean examinations. In addition, a patient satisfaction survey was conducted at 9 months post-procedure to evaluate patients’ subjective experience with the procedure. Results: Fourteen myopic eyes (mean manifest refraction spherical equivalent –1.62±0.6D; range –0.75 to –2.65D of 8 subjects (mean age 30 years old; range 24–51 years old were enrolled in the study. At 12 months post-procedure, a mean manifest refraction spherical equivalent reduction of 0.72±0.43D (P<0.001 was observed, with a corresponding gain in uncorrected visual acuity of 0.25 logMAR and mean K-mean flattening of 0.47±0.46D. All patients achieved best corrected visual acuity of 20/20 or better from 1 month onward. There were no cases of ocular infection or secondary changes to the crystalline lens and retina due to UV exposure, while transient corneal haze subsided gradually. Conclusion: The epithelium-on PiXL procedure was safe and effective in reducing myopic refractive error in this study with up to 12 months follow-up. Early results of

  11. Efficacy and safety of metformin or oral contraceptives, or both in polycystic ovary syndrome

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    Yang YM

    2015-09-01

    Full Text Available Young-Mo Yang, Eun Joo Choi College of Pharmacy, Chosun University, Gwangju, South Korea Background: Polycystic ovary syndrome (PCOS is an endocrinopathy that affects approximately 10% of reproductive-aged women throughout their lives. Women with PCOS present with heterogeneous symptoms including ovulatory dysfunction, hyperandrogenism, and polycystic ovaries. Therefore, lifelong individualized management should be considered. Pharmacological agents commonly used to manage the symptoms are metformin and oral contraceptive pills. Although these medications have been beneficial in treating PCOS symptoms, their efficacy and safety are still not entirely elucidated. This study aimed to report the efficacy and safety of metformin, oral contraceptives, or their combination in the treatment of PCOS and to define their specific individual roles.Methods: A literature search of original studies published in PubMed and Scopus was conducted to identify studies comparing metformin with oral contraceptives or evaluating the combination of both in PCOS.  Results: Eight clinical trials involving 313 patients were examined in the review. The intervention dosage of metformin ranged from 1,000 to 2,000 mg/d and that of oral contraceptives was ethinylestradiol 35 µg and cyproterone acetate 2 mg. Lower body mass index was observed with regimens including metformin, but increased body mass index was observed in monotherapy with oral contraceptives. Administration of metformin or oral contraceptives, especially as monotherapy, had a negative effect on lipid profiles. In addition, there are still uncertainties surrounding the effects of metformin or oral contraceptives in the management of insulin level, although they improved total testosterone and sex hormone-binding globulin levels. In the included studies, significant side effects due to metformin or oral contraceptives were not reported.  Conclusion: The clinical trials suggest that metformin or oral

  12. PEGylated apoptotic protein-loaded PLGA microspheres for cancer therapy

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    Byeon HJ

    2015-01-01

    Full Text Available Hyeong Jun Byeon,1 Insoo Kim,1 Ji Su Choi,1 Eun Seong Lee,2 Beom Soo Shin,3 Yu Seok Youn11Department of Pharmaceutical Sciences, School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea; 2Division of Biotechnology, The Catholic University of Korea, Bucheon-si, Republic of Korea; 3Department of Pharmacy, College of Pharmacy, Catholic University of Daegu, Gyeongsan-si, Republic of KoreaAbstract: The aim of the current study was to investigate the antitumor potential of poly(D,L-lactic-co-glycolic acid microspheres (PLGA MSs containing polyethylene glycol (PEG-conjugated (PEGylated tumor necrosis factor–related apoptosis-inducing ligand (PEG-TRAIL. PEG-TRAIL PLGA MSs were prepared by using a water-in-oil-in-water double-emulsion method, and the apoptotic activities of supernatants released from the PLGA MSs at days 1, 3, and 7 were examined. The antitumor effect caused by PEG-TRAIL PLGA MSs was evaluated in pancreatic Mia Paca-2 cell-xenografted mice. PEG-TRAIL PLGA MS was found to be spherical and 14.4±1.06 µm in size, and its encapsulation efficiency was significantly greater than that of TRAIL MS (85.7%±4.1% vs 43.3%±10.9%, respectively. The PLGA MS gradually released PEG-TRAIL for 14 days, and the released PEG-TRAIL was shown to have clear apoptotic activity in Mia Paca-2 cells, whereas TRAIL released after 1 day had a negligible activity. Finally, PEG-TRAIL PLGA MS displayed remarkably greater antitumor efficacy than blank or TRAIL PLGA MS in Mia Paca-2 cell-xenografted mice in terms of tumor volume and weight, apparently due to increased stability and well-retained apoptotic activity of PEG-TRAIL in PLGA MS. We believe that this PLGA MS system, combined with PEG-TRAIL, should be considered a promising candidate for treating pancreatic cancer.Keywords: Poly(D,L-lactic-co-glycolic acid, controlled release, PEGylation, TRAIL, pancreatic cancer

  13. Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

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    Seo JH

    2015-07-01

    Full Text Available Jae Hong Seo, Jung Bae Park, Woong-Kee Choi, Sunhwa Park, Yun Jin Sung, Euichaul Oh, Soo Kyung Bae College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea Objective: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavailability of cilostazol.Methods: Cilostazol mesylate and cilostazol besylate were synthesized from cilostazol by acid addition reaction with methane sulfonic acid and benzene sulfonic acid, respectively. The salt preparations were characterized by nuclear magnetic resonance spectroscopy. The water contents, hygroscopicity, stress stability, and photostability of the two cilostazol salts were also determined. The dissolution profiles in various pH conditions and pharmacokinetic studies in rats were compared with those of cilostazol-free base.Results: The two cilostazol salts exhibited good physicochemical properties, such as nonhygroscopicity, stress stability, and photostability, which make it suitable for the preparation of pharmaceutical formulations. Both cilostazol mesylate and cilostazol besylate showed significantly improved dissolution rate and extent of drug release in the pH range 1.2–6.8 compared to the cilostazol-free base. In addition, after oral administration to rats, cilostazol mesylate and cilostazol besylate showed increases in Cmax and AUCt of approximately 3.65- and 2.87-fold and 3.88- and 2.94-fold, respectively, compared to cilostazol-free base.Conclusion: This study showed that two novel salts of cilostazol, such as cilostazol mesylate and cilostazol besylate, could be used to enhance its oral absorption. The findings warrant further preclinical and clinical studies on cilostazol mesylate and

  14. Relationship between alexithymia and coping strategies in patients with somatoform disorder

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    Tominaga T

    2013-12-01

    Full Text Available Toshiyuki Tominaga,1,4 Hyungin Choi,2 Yasuhide Nagoshi,3 Yoshihisa Wada,4 Kenji Fukui41Health Management Doctor's Office (Mental Health, Salary, Personnel Health, and Welfare Division, Kyoto Prefecture, Japan; 2Department of Psychiatry, Iwakura Hospital, Kyoto, Japan; 3Department of Psychiatry (Psychosomatic Medicine, Kyoto First Red Cross Hospital, Kyoto, Japan; 4Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanPurpose: A multidimensional intervention integrating alexithymia, negative affect, and type of coping strategy is needed for the effective treatment of somatoform disorder; however, few studies have applied this approach to the three different dimensions of alexithymia in patients with somatoform disorder. The purpose of this study was to determine the relationship between type of coping strategy and three different dimensions of alexithymia expressed in patients.Patients and methods: A total of 196 patients with somatoform disorder completed the 20-item Toronto Alexithymia Scale, the Zung Self-Rating Depression Scale, the Spielberger State–Trait Anxiety Inventory, the Somatosensory Amplification Scale, and the Lazarus Stress Coping Inventory. The relationships between alexithymia (Toronto Alexithymia Scale – 20 score and subscales, demographic variables, and psychological inventory scores were analyzed using Pearson's correlation coefficients and stepwise multiple regression analysis.Results: The mean Toronto Alexithymia Scale – 20 total score (56.1±10.57 was positively correlated with the number of physical symptoms as well as with psychopathology scores (Self-Rating Depression Scale, State–Trait Anxiety Inventory trait, state, and Somatosensory Amplification Scale, but negatively correlated with planful problem solving, confrontive coping, seeking social support, and positive reappraisal coping scores. With respect to coping strategy, multiple regression

  15. EDITORIAL: Welcome to the 2012 volume Welcome to the 2012 volume

    Science.gov (United States)

    Garcia, Ephrahim

    2012-01-01

    articles last year, as well as our authors and contributors for submitting their high quality research. We very much look forward to your further involvement with the journal in 2012. Finally, I would like to extend a huge thank you to our diverse Board of Associate Editors who have devoted their time and energy giving invaluable advice on each submitted article, and have been dedicated ambassadors for SMS. A special welcome to Professor Kwang J Kim who joined the Board a few months ago. Professor D Abbott, University of Adelaide, Australia Professor G Akhras, Royal Military College of Canada, Ontario, Canada Professor C Boller, University of Saarland, Saarbrücken, Germany; Fraunhofer-Institut für Zerstörungsfreie Prüfverfahren, Dresden, Germany Professor Cagnol, École Centrale Paris, France Professor G Carman, University of California-Los Angeles, USA Professor S-B Choi, Inha University, Incheon, Korea Dr S H Choi, NASA Langley Research Center, Hampton, VA, USA Professor A Del Grosso, Università degli Studi di Genova, Italy Professor D Erickson, Cornell University, Ithaca, NY, USA Professor A Flatau, University of Maryland, College Park, USA Professor U Gabbert, Universität Magdeburg, Germany Professor A Güemes, Universidad Politecnica de Madrid, Spain Professor S Gopalakrishnan, Indian Institute of Science, Bangalore, India Professor J Kim, Inha University, Incheon, Korea Professor K J Kim, University of Nevada, Reno, USA Professor S J Kim, Seoul National University, Korea Professor D Lagoudas, Texas A&M University, College Station, USA Professor R Lammering, Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Hamburg, Germany Professor C K Lee, National Taiwan University, Taiwan Professor J Leng, Harbin Institute of Technology, China Professor W Li, University of Wollongong, Australia Professor W H Liao, Chinese University of Hong Kong, China Professor C S Lynch, University of California-Los Angeles, USA Dr S Masri, University of Southern California

  16. Regional distribution and relevance in paleonvironmental studies of lakes in the Tatra Mts. (Western Carpathians

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    Joanna POCIASK-KARTECZKA

    2014-11-01

    Full Text Available Scientific limnological research in the Tatra Mountains were initiated by Stanislaw Staszic in the early XIX century.  After the World War II, the evolution of Tatra lakes was investigated by Kondracki, Klimaszewski, Baumgart-Kotarba and. Extensive paleolimnological investigations in the Tatra Mountains were started by the group of scientists led by K. Starmach in the beginning of the second half of the 20th century. There has been not much research concerned to the regional distribution of lakes and their properties in the Tatra Mountains (Pociask-Karteczka 2013. Very early division of lakes presented A. Gadomski (1922, which distinguished four types of lakes: a tarns (cirque lake or corrie loch, b bedrock-dammed lakes, c moraine lakes. This division was concerned in subsequent publications (Choiński 2007. M. Lukniš (1973, 1985 recognized additional types: kettles and landslide-dammed lakes and M. Klimaszewski (1988 – inter-sheepback lakes. J. Pacl and K. Wit-Jóźwik in Klima Tatier (Pacl, Wit-Jóźwik 1974 were focused on the temperature of water in lakes in Polish and Slovak parts and M. Borowiak (2000a,b provided a comprehensive analysis of types, dimensions, temperature and chemical composition of water in lakes in the Tatra Mountains.According to present day state of knowledge, one may distinguish following genetic types of lakes: I glacial, II not-glacial. There are four types of the glacial origin lakes in the Tatra Mountains (Fig. 1: a tarns (cirque lakes or corrie loch, b bedrock-moraine dammed lakes, c inter-sheepback lakes, d moraine lakes, e kettles.Most of lakes in the Tatra Mountains are tarns and bedrock-moraine dammed lakes, and they are located at the elevation over 1400 m a.s.l. in the Western Tatra Mountains, and over 1600 m a.s.l. in the High Tatra Mountains. Some of them are paternoster lakes – a series of stair-stepped lakes formed in individual rock basins aligned down the course of a glaciated valley. Lakes in

  17. Does breast density measured through population-based screening independently increase breast cancer risk in Asian females?

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    Park B

    2017-12-01

    Full Text Available Boyoung Park,1,2 Hye Mi Cho,2 Eun Hye Lee,3 Seunghoon Song,2 Mina Suh,2 Kui Son Choi,1,2 Bong Joo Kang,4 Kyungran Ko,5 Ann Yi,6 Hae Kyoung Jung,7 Joo Hee Cha,8 Jae Kwan Jun,1,2 1National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Republic of Korea; 2National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea; 3Department of Radiology, Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea; 4Department of Radiology, Seoul St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Republic of Korea; 5Center for Breast Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Republic of Korea; 6Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea; 7Department of Radiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 8Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case–control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS. Associations between BI-RADS density and breast cancer risk were evaluated according to screening results, time elapsed since receiving non-recall results, age, and menopausal status after adjusting for possible covariates. Results: Breast cancer risk for women with extremely dense breasts was five times higher (adjusted odds ratio [aOR] =5.0; 95% confidence interval [CI] =3

  18. Chronic bronchitis is an independently associated factor for more symptom and high-risk groups

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    Choi JY

    2016-06-01

    Full Text Available Joon Young Choi,1 Hyoung Kyu Yoon,2 Seoung Ju Park,3 Yong Bum Park,4 Kyeong-Cheol Shin,5 Ju Ock Na,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Young Kyoon Kim,1 Chin Kook Rhee1 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, 4Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, 5Regional Center for Respiratory Disease, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, Republic of Korea Background: The chronic bronchitis (CB phenotype has been associated with poor quality of life and an increased risk of disease in patients with COPD. However, little information exists regarding the relationship between the CB phenotype and the COPD assessment test (CAT score. The goal of this study was to reveal the different pattern of CAT scores between CB and non-CB patients. Moreover, we aimed to investigate whether the CB phenotype is an independently associated factor for more symptom and high-risk groups.Methods: Data were obtained from the Korea COPD Subgroup Study cohort recruited from 46 centers in South

  19. Prevalence of and risk factors for postoperative pulmonary complications after lung cancer surgery in patients with early-stage COPD

    Directory of Open Access Journals (Sweden)

    Kim ES

    2016-06-01

    Full Text Available Eun Sun Kim,1 Young Tae Kim,2 Chang Hyun Kang,2 In Kyu Park,2 Won Bae,1 Sun Mi Choi,1 Jinwoo Lee,1 Young Sik Park,1 Chang-Hoon Lee,1 Sang-Min Lee,1 Jae-Joon Yim,1 Young Whan Kim,1 Sung Koo Han,1 Chul-Gyu Yoo1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea Purpose: This study aimed to investigate whether the prevalence of postoperative pulmonary complications (PPCs in patients with non-small-cell lung cancer (NSCLC is even higher in the early stages of COPD than in such patients with normal lung function and to verify the usefulness of symptom- or quality of life (QoL-based scores in predicting risk for PPCs.Patients and methods: Patients undergoing pulmonary resection for NSCLC between July 2012 and October 2014 were prospectively enrolled. Preoperative measurements of lung function, dyspnea, and QoL, operative characteristics, PPCs, duration of postoperative hospitalization, and in-hospital mortality were assessed.Results: Among 351 consecutive patients with NSCLC, 343 patients with forced expiratory volume in 1 second (FEV1 ≥70% of predicted value were enrolled. At least one PPC occurred in 57 (16.6% patients. Prevalence of PPC was higher in patients with COPD (30.1% than in those with normal spirometry (10.0%; P<0.001. However, in patients with COPD, the prevalence of PPC was not different in patients with FEV1 ≥70% compared to those with FEV1 <70% and between group A (low risk and less symptoms and group B (low risk and more symptoms patients with COPD, based on the new Global initiative for chronic Obstructive Lung Disease 2011 guidelines. In patients with COPD, body mass index (odds ratio [OR]: 0.80, P=0.007, carbon monoxide diffusing capacity of the lung (DLCO, % predicted value (OR: 0.97, P=0.024, and operation time (OR: 1.01, P=0.003, but not COPD assessment test or St

  20. Impacts of coexisting bronchial asthma on severe exacerbations in mild-to-moderate COPD: results from a national database

    Directory of Open Access Journals (Sweden)

    Lee H

    2016-04-01

    Full Text Available Hyun Lee,1 Chin Kook Rhee,2 Byung-Jae Lee,3 Dong-Chull Choi,3 Jee-Ae Kim,4 Sang Hyun Kim,5 Yoolwon Jeong,6 Tae-Hyung Kim,7 Gyu Rak Chon,8 Ki-Suck Jung,9 Sang Haak Lee,10 David Price,11 Kwang Ha Yoo,12,* Hye Yun Park1,* 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea, 3Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 4Pharmaceutical Policy Evaluation Research Team, Research Institution, Health Insurance Review and Assessment Service, 5Big Data Division, Health Insurance Review and Assessment Service, Seoul, 6Division of Chronic Disease Control, Korea Centers for Disease Control and Prevention, Osong, 7Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, 8Department of Pulmonary and Critical Care Medicine, Chungju Hospital, Konkuk University School of Medicine, Chungju City, 9Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Medical Center, Hallym University College of Medicine, Anyang, 10Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 11Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; 12Division of Pulmonary, Allergy and Critical Care Medicine Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea *These authors contributed equally to this work Backround: Acute exacerbations are major drivers of COPD deterioration. However, limited data are available for the

  1. Effect of tiotropium on lung function decline in early-stage of chronic obstructive pulmonary disease patients: propensity score-matched analysis of real-world data

    Directory of Open Access Journals (Sweden)

    Lee HY

    2015-10-01

    Full Text Available Ha Youn Lee,1,2 Sun Mi Choi,1,2 Jinwoo Lee,1,2 Young Sik Park,1,2 Chang-Hoon Lee,1,2 Deog Kyeom Kim,2,3 Sang-Min Lee,1,2 Ho Il Yoon,2,4 Jae-Joon Yim,1,2 Young Whan Kim,1,2 Sung Koo Han,1,2 Chul-Gyu Yoo1,2 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 3Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Background: Tiotropium failed to slow the annual rate of forced expiratory volume in 1 second (FEV1 decline in chronic obstructive pulmonary disease (COPD patients with <70% predicted FEV1. However, the rate of FEV1 decline is known to be faster at early stages, which suggests that the effects of tiotropium may be more prominent in early-stage of COPD patients. The aim of this study was to test the hypothesis that tiotropium modifies the rate of FEV1 decline in COPD patients with an FEV1≥70%.Methods: We retrospectively reviewed the records of COPD patients diagnosed between January 1, 2004, and July 31, 2012, at Seoul National University Hospital, Seoul National University Bundang Hospital, and Seoul Metropolitan Government-Seoul National University Boramae Medical Center. The inclusion criteria were as follows: age ≥40 years, postbronchodilator (BD FEV1≥70% of predicted and FEV1/FVC (forced vital capacity <0.70, and spirometry more than two times at certain times of the year. Conversely, the exclusion criteria were as follows: asthma, lung cancer, pulmonary tuberculosis, pulmonary resection, or long-term use of a short-acting muscarinic antagonist. The annual lung function decline in patients using tiotropium was compared with that in patients not

  2. A Diagnosis Support System for Abnormal Situations of Hanbit Units 3 and 4

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yochan; Jung, Wondea [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    Livecode 6.1. A flowchart of the AOPs was generated through the C 5.0 package in R software. The data about the alarms and AOPs were obtained from Hanbit units 3 and 4. With the developed search engine, the operators can easily find AOPs from the given alarms. However, because the operators need to be able to efficiently cope with abnormal situations without digital devices, usable educational tools for new human resources should be developed. The developed system shows some examples of such education tools. The flowchart can be used not only for understanding the relation between AOPs and alarms in Hanbit units 3 and 4 MCRs, but also for an actual diagnosis of abnormal situations under a lack of information without computerized search tools. The mimic alarm window also delivers characteristics of AOPs to operators. It is expected that the developed system can cognitively support the operator to diagnose abnormal situations compared with previous attempts. Choi et al. developed a flowchart similar to the flowchart in this system.

  3. Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

    Directory of Open Access Journals (Sweden)

    Yousaf AM

    2015-03-01

    Full Text Available Abid Mehmood Yousaf,1 Dong Wuk Kim,1 Yu-Kyoung Oh,2 Chul Soon Yong,3 Jong Oh Kim,3 Han-Gon Choi11College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, 2College of Pharmacy, Seoul National University, Seoul, 3College of Pharmacy, Yeungnam University, Gyongsan, South KoreaBackground: The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate.Methods: The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS, fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder.Results: Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in

  4. Phylogenetic Diversity of Vibrio cholerae Associated with Endemic Cholera in Mexico from 1991 to 2008.

    Science.gov (United States)

    Choi, Seon Young; Rashed, Shah M; Hasan, Nur A; Alam, Munirul; Islam, Tarequl; Sadique, Abdus; Johura, Fatema-Tuz; Eppinger, Mark; Ravel, Jacques; Huq, Anwar; Cravioto, Alejandro; Colwell, Rita R

    2016-03-15

    in Mexico prior to the 1990s, genetically diverse V. cholerae O1 strains were isolated between 1991 and 2008. Despite the lack of strong evidence, the notion that cholera was transmitted from Africa to Latin America has been proposed in the literature. In this study, we have applied whole-genome sequence analysis to a set of 124 V. cholerae strains, including six Mexican isolates, to determine their phylogenetic relationships. Phylogenetic analysis indicated the six V. cholerae O1 isolates belong to five phylogenetic clades: i.e., basal, nontoxigenic, classical, El Tor, and hybrid El Tor. Thus, the results of phylogenetic analysis, coupled with CTXϕ array and antibiotic susceptibility, do not support single-source transmission of cholera to Mexico from African countries. The association of indigenous populations of V. cholerae that has been observed in this study suggests it plays a significant role in the dynamics of cholera in Mexico. Copyright © 2016 Choi et al.

  5. [Dentistry in Korean during the Japanese occupation].

    Science.gov (United States)

    Shin, Jae-Eu

    2004-12-01

    The Japanese introduction of dentistry into Korea was for treating the Japanese residing in Korea Noda-Oji was the first Japanese dentist for Japanese people in Korea in 1893, and Narajaki doyoyo, an invited dentist was posted in the Korean headquarter of Japanese army in September, 1905. The imperialist Japan licensed the dental technicians (yipchisa) without limit and controlled them generously so they could practice dentistry freely. This measure was contrary to that in Japan. (In Japan no new dental technician was licensed.) Komori, a dental technician opened his laboratory at Chungmuro in 1902. The dental technician had outnumbered by 1920. In 1907, the first Korean dental technician Sung-Ryong Choi practiced dentistry in Jongno. The imperialist Japan made the regulations for dental technicians to set a limit to the advertisement and medical practice of dental technicians. The first Korean dentists Suk-Tae Ham was register No. 1 in the dentist license. The Kyungsung dental school was established by Nagira Dasoni for the purpose of educating some Korean people that contributed to Japanese colonization. It made progress with the help of Japan, it was was given the approval of the establishment of the professional school in January the 25th, 1929. It was intended to produce Korean dentists in the first place but became the school for Japanese students later on. The association of Chosun dentist, which had been founded by Narajaki doyoyo, was managed by Japanese dentists in favor of the colonial ruling. The Hansung Association of Dentists established in 1925 was the organization made by the necessity of the association for Koreans only. The Japanese forcefully annexed the Association of Hansung Dentists (Koreans only) to the Association of Kyungsung Dentists to avoid collective actions of Korean dentists in the name of 'Naesunilche' -- 'Japan and Korea and one'. Their invading intention was shown in the event of 'decayed tooth preventive day'. Japanese controlled

  6. Dentistry in Korea during the Japanese Occupation

    Directory of Open Access Journals (Sweden)

    SHIN Jae-Eu

    2004-12-01

    Full Text Available The Japanese introduction of dentistry into Korea was for treating the Japanese residing in Korea Noda-Oji was the first Japanese dentist for Japanese people in Korea in 1893. and Narajaki doyoyo, an invited dentist was posted in the Korean headquarter of Japanese army in september, 1905. The imperialist Japan licensed the dental technicians(yipchisa without limit and controled them generously so they could practice dentistry freely. This measure was contrary to that in Japan. (In Japan no new dental technician was licensed. Komori, a dental technician opened his laboratory at Chungmuro in 1902. The dental technician had outnumerbered by 1920. In 1907, the first Korean dental technician Sung-Ryong Choi practiced dentistry in Jongno. The imperialist Japan made the regulation for dental technicians to set a limit to the advertisement and medical practice of dental technicians. The first Korean dentist Suk-Tae Ham was registered No. 1 in the dentist license. The Kyungsung dental school was established by Nagira Dasoni for the purpose of educating some korean people that contributed to Japanese colonization. It made progress with the help of Japan. it was given the approval of the establishment of the professional school in January the 25th, 1929. it was intended to produce Korean dentists in the first place but became the school for Japanese students later on. The association of Chosun dentist, which had been founded by Narajaki doyoyo, was managed by Japanese dentists in favor of the colonial ruling. The Hansung Association of Dentists established in 1925 was the organization made by the necessity of the association for Koreans only. the Japanese forcefully annexed the Association of Hansung Dentists (Koreans only to the Association of Kyungsung Dentists to avoid collective actions of Korean dentists in the name of 'Naesunilche'--'Japan and Korea are one'. Their invading intention was shown in the event of 'decayed tooth preventive day'. Japanese

  7. Impact of Mental Health Screening on Promoting Immediate Online Help-Seeking: Randomized Trial Comparing Normative Versus Humor-Driven Feedback.

    Science.gov (United States)

    Choi, Isabella; Milne, David N; Deady, Mark; Calvo, Rafael A; Harvey, Samuel B; Glozier, Nick

    2018-04-05

    younger adults were less likely to click on the link compared to older adults across all measures (P=.005, OR 0.44, 95% CI 0.25-0.78). This pilot study found that there was no difference between normative and humor-driven feedback on promoting immediate clicks to an external resource, suggesting no impact on online help-seeking. Limitations included: lack of personal score control group, limited measures of predictors and potential confounders, and the fact that other forms of professional help-seeking were not assessed. Further investigation into other predictors and factors that impact on help-seeking is needed. Australian New Zealand Clinical Trials Registry ACTRN12616000707460; https://www.anzctr.org.au/ Trial/Registration/TrialReview.aspx?id=370187 (Archived by WebCite at http://www.webcitation.org/6y8m8sVxr). ©Isabella Choi, David N Milne, Mark Deady, Rafael A Calvo, Samuel B Harvey, Nick Glozier. Originally published in JMIR Mental Health (http://mental.jmir.org), 05.04.2018.

  8. A nanohybrid system for taste masking of sildenafil

    Directory of Open Access Journals (Sweden)

    Lee JH

    2012-03-01

    Full Text Available Ji-Hee Lee1,*, Goeun Choi1,*, Yeon-Ji Oh1, Je Won Park1, Young Bin Choy3, Mung Chul Park1, Yeo Joon Yoon1, Hwa Jeong Lee2, Hee Chul Chang4, Jin-Ho Choy1 1Center for Intelligent Nano-Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nano Science, 2Division of Life and Pharmaceutical Sciences and College of Pharmacy, Ewha Womans University, Seoul, Korea; 3Department of Biomedical Engineering, College of Medicine and Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea; 4Global Strategy Center and Pharmaceutical Research Institute, Daewoong Pharmaceutical Co., Ltd., Seoul, Korea*These authors contributed equally to this workAbstract: A nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT, for taste masking of sildenafil (SDN. To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN–MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA. Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was successfully intercalated into the interlayer space of MMT. The AEA-coated SDN–MMT nanohybrid showed drug release was much suppressed at neutral pH (release rate, 4.70 ± 0.53%, suggesting a potential for drug taste masking at the buccal cavity. We also performed in vitro drug release experiments in a simulated gastric fluid (pH = 1.2 and compared the drug-release profiles of AEA-coated SDN–MMT and Viagra®, an approved dosage form of SDN. As a result, about 90% of SDN was released from the AEA-coated SDN–MMT during the first 2 hours while almost 100% of drug was released from Viagra®. However, an in vivo experiment showed that the AEA-coated SDN–MMT exhibited higher drug exposure than Viagra®. For the AEA-coated SDN–MMT, the area under the plasma concentration–time curve from 0 hours to infinity (AUC0-∞ and maximum

  9. A new experimental system for study on adaptive mutations

    Institute of Scientific and Technical Information of China (English)

    Lü; Zhong; (

    2001-01-01

    [1]Luria, S. E., Delbrück, M., Mutation of bacteria from virus sensitivity to virus resistance, Genetics, 1943, 28: 491.[2]Lederberg, J., Lederberg, E. M., Replica plating and indirect selection of bacteria mutants, J. Bacteriol., 1952, 63: 399.[3]Carins, J., Overbaugh, J., Miller, S., The origin of mutants, Nature, 1988, 355: 142.[4]Foster, P. L., Adaptive mutation: the uses of adversity, Annu. Rev. Microbiol., 1993, 47: 467.[5]Hall, B. G., Adaptive mutagenesis: a process that generates almost exclusively beneficient mutations, Genetica, 1998, 102/103: 109.[6]Kasak, L., Horak, R., Kivisaar, M., Promotor-creating mutations in Psuedmonas putida: A model system for the study of mutation in starving bacteria, PNAS, 1997, 94: 3134.[7]Steele, D. F., Jinks-Robertson, An examination of adaptive reversion in Saccharomyces cerevisiae, Genetics, 1992, 132: 9.[8]Davis, R. W., Botstein, Roth, J. R., Advanced Bacterial Genetics--A Manual for Genetic Engineering, New York: Cold Spring Harbor Laboratory Press, 1980, 13.[9]Miller, J. H., Experiments in Molecular Genetics, New York: Cold Spring Harbor Laboratory Press, 1972, 352.[10] Lea, D. E., Coulson, C. A., The distribution of the numbers of mutants in bacterial populations, J. Genetics, 1949, 49: 264.[11] Hughes, K. T., Roth, J. R., Transitory cis complementation: a method for provided transposition function to defective transposons, Genetics, 1988, 119: 9.[12] Sanderson, K. E., Roth J., Linkage map of Salmonella typhimurium, Microbiol. Rev., 1988, 52: 485.[13] He, B., Shiau, A., Choi, K. Y., Genes of the E. coli pur region are negatively controlled by a repressor-operator interaction, J. Bacteriol., 1990, 172: 4555.[14] Liu, B., Huang, Y., Wang, A. Q., Regulation of purine biosynthetic genes expression in Salmonella typhimurium (IV)--Oc mutation site of purG and its function analysis, Science in China, Ser. C, 1997, 40(3): 238.[15] Tang, H., Qin, J. C., Wang, A. Q

  10. Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

    Directory of Open Access Journals (Sweden)

    Kim YW

    2014-02-01

    Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the

  11. Association of systolic blood pressure drop with intravenous administration of itraconazole in children with hemato-oncologic disease

    Directory of Open Access Journals (Sweden)

    Lee HJ

    2015-12-01

    Full Text Available Hyeong Jin Lee,1,* Bongjin Lee,2,* June Dong Park,2 Hyung Joo Jeong,2 Yu Hyeon Choi,2 Hee Young Ju,1 Che Ry Hong,1 Ji Won Lee,1 Hyery Kim,1 Dong In Suh,3 Kyung Duk Park,1 Hyoung Jin Kang,1 Hee Young Shin,1 Hyo Seop Ahn1 1Department of Pediatrics, Cancer Research Institute, 2Division of Pediatric Intensive Care, Department of Pediatrics, 3Division of Pulmonology, Department of Pediatrics, Seoul National University College of Medicine, Seoul National University, Seoul, South Korea *These authors contributed equally to this work Purpose: Although few adverse effects have been reported for itraconazole, a widely used antifungal therapy for febrile neutropenia, we found intravenous (IV itraconazole to be associated with serious cases of blood pressure (BP drop. We therefore evaluated the incidence and risk factors for BP drop during IV administration of the drug.Materials and methods: We reviewed the medical records of children with hemato-oncologic disease who were treated with IV itraconazole from January 2012 to December 2013. By analyzing systolic BP (SBP measurements made from 4 hours before through to 4 hours after itraconazole administration, we evaluated the changes in SBP and the risk factors for an SBP drop, especially clinically meaningful (≥20% drops.Results: Itraconazole was administered 2,627 times to 180 patients. The SBP during the 4 hours following itraconazole administration was lower than during the 4 hours before administration (104 [53.0–160.33 mmHg] versus 105 [59.8–148.3 mmHg]; P<0.001. The decrease in SBP was associated with the application of continuous renal replacement therapy (CRRT (P=0.012 and the use of inotropic (P=0.005 and hypotensive drugs (P=0.021. A clinically meaningful SBP drop was seen in 5.37% (141 out of 2,627 of the administrations, and the use of inotropics (odds ratio [OR] 6.70, 95% confidence interval [CI] 3.22–13.92; P<0.001, reducing the dose of inotropics (OR 8.08; 95% CI 1.39–46.94; P=0

  12. Design of a novel theranostic nanomedicine: synthesis and physicochemical properties of a biocompatible polyphosphazene–platinum(II conjugate

    Directory of Open Access Journals (Sweden)

    Avaji PG

    2016-03-01

    Full Text Available Prakash G Avaji,1,2,* Jung Hyun Park,1,* Hyun Jeong Lee,1 Yong Joo Jun,2 Kyung Su Park,3 Kyung Eun Lee,3 Soo-Jin Choi,4 Hwa Jeong Lee,1 Youn Soo Sohn2 1Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea; 2C & Pharm, Ewha Womans University, Seoul, Republic of Korea; 3Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: To develop a theranostic nanomedicine involving the antitumor-active moiety (dachPt(II (dach: trans-(±-1,2-diaminocyclohexane of oxaliplatin (OX, a new biocompatible polyphosphazene carrier polymer was designed by grafting with a methoxy poly(ethylene glycol (MPEG to increase duration of circulation in the blood and with aminoethanol (AE as a spacer group. The antitumor (dachPt moiety was conjugated to the carrier polymer using cis-aconitic acid (AA as a linker, resulting in a polymer conjugate formulated as [NP(MPEG550(AE-AAPt(dach]n, named “Polyplatin” (PP. PP was found to self-assemble into very stable polymeric nanoparticles with a mean diameter of 55.1 nm and a critical aggregation concentration of 18.5 mg/L in saline. PP could easily be labeled with a fluorescence dye such as Cy5.5 for imaging studies. The time-dependent ex vivo image studies on organ distributions and clearance of Cy-labeled PP have shown that PP accumulated in the tumor with high selectivity by the enhanced permeability and retention effect but was cleared out from all the major organs including the liver in about 4 weeks postinjection. Another time-dependent bioimaging study on distribution and clearance of PP in mouse kidney using laser ablation inductively coupled plasma mass spectroscopy has shown that PP accumulates much less in kidney and is more rapidly excreted than monomeric OX, which is in accord with the

  13. Trends in HIV Terminology: Text Mining and Data Visualization Assessment of International AIDS Conference Abstracts Over 25 Years.

    Science.gov (United States)

    Dancy-Scott, Nicole; Dutcher, Gale A; Keselman, Alla; Hochstein, Colette; Copty, Christina; Ben-Senia, Diane; Rajan, Sampada; Asencio, Maria Guadalupe; Choi, Jason Jongwon

    2018-05-04

    "men who have sex with men" and "MSM" were rarely used until 1994; subsequently, use of these terms increased through 2014. The term "sex worker" steadily increased in frequency throughout conference years, whereas the term "prostitute" decreased over time. The results of this study highlight changes in HIV terminology use over 25 years, including the addition, disappearance, and changing use of terms that reflect advances in HIV research and medical practice and destigmatization of the disease. Coupled with findings from related quantitative research, HIV-related terminology recommendations based on results of this study are included. Adoption of these recommendations will further efforts to use less stigmatizing language and facilitate effective communication between health professionals and people affected by HIV. ©Nicole Dancy-Scott, Gale A Dutcher, Alla Keselman, Colette Hochstein, Christina Copty, Diane Ben-Senia, Sampada Rajan, Maria Guadalupe Asencio, Jason Jongwon Choi. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 04.05.2018.

  14. A Diagnosis Support System for Abnormal Situations of Hanbit Units 3 and 4

    International Nuclear Information System (INIS)

    Kim, Yochan; Jung, Wondea

    2013-01-01

    .1. A flowchart of the AOPs was generated through the C 5.0 package in R software. The data about the alarms and AOPs were obtained from Hanbit units 3 and 4. With the developed search engine, the operators can easily find AOPs from the given alarms. However, because the operators need to be able to efficiently cope with abnormal situations without digital devices, usable educational tools for new human resources should be developed. The developed system shows some examples of such education tools. The flowchart can be used not only for understanding the relation between AOPs and alarms in Hanbit units 3 and 4 MCRs, but also for an actual diagnosis of abnormal situations under a lack of information without computerized search tools. The mimic alarm window also delivers characteristics of AOPs to operators. It is expected that the developed system can cognitively support the operator to diagnose abnormal situations compared with previous attempts. Choi et al. developed a flowchart similar to the flowchart in this system

  15. The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

    Directory of Open Access Journals (Sweden)

    Lee JA

    2015-03-01

    Full Text Available Jeong-A Lee,1,* Mi-Kyung Kim,1,* Hyoung-Mi Kim,2,* Jong Kwon Lee,3 Jayoung Jeong,4 Young-Rok Kim,5 Jae-Min Oh,2 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Republic of Korea; 3Hazard Substances Analysis Division, Gwangju Regional Food and Drug Administration, Ministry of Food and Drug Safety, Gwangju, Republic of Korea; 4Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungcheongbuk-do, Republic of Korea; 5Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Republic of Korea *These authors contributed equally to this work Background: Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.Methods: We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m2/g, respectively on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.Results: N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen

  16. A genetic screen of the mutations in the Korean patients with early-onset Alzheimer’s disease

    Directory of Open Access Journals (Sweden)

    An SS

    2016-12-01

    Full Text Available Seong Soo An,1,* Sun Ah Park,2,* Eva Bagyinszky,1 Sun Oh Bae,1 Yoon-Jeong Kim,2 Ji Young Im,2 Kyung Won Park,3 Kee Hyung Park,4 Eun-Joo Kim,5 Jee Hyang Jeong,6 Jong Hun Kim,7 Hyun Jeong Han,8 Seong Hye Choi,9 SangYun Kim10 1Department of Bionano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, 4Department of Neurology, Gachon University Gil Medical Center, Incheon, 5Department of Neurology, Pusan National University Hospital, Busan, 6Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, 7Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, 8Department of Neurology, Myongii Hospital, Goyang, 9Department of Neurology, Inha University School of Medicine, Incheon, 10Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: Early-onset Alzheimer’s disease (EOAD has distinct clinical characteristics in comparison to late-onset Alzheimer’s disease (LOAD. The genetic contribution is suggested to be more potent in EOAD. However, the frequency of causative mutations in EOAD could be variable depending on studies. Moreover, no mutation screening study has been performed yet employing large population in Korea. Previously, we reported that the rate of family history of dementia in EOAD patients was 18.7% in a nationwide hospital-based cohort study, the Clinical Research Center for Dementia of South Korea (CREDOS study. This rate is much lower than in other countries and is even comparable to the frequency of LOAD patients in our country. To understand the genetic characteristics of EOAD in Korea, we screened the common Alzheimer’s disease (AD

  17. Methods to induce primary and secondary traumatic damage in organotypic hippocampal slice cultures.

    Science.gov (United States)

    Adamchik, Y; Frantseva, M V; Weisspapir, M; Carlen, P L; Perez Velazquez, J L

    2000-04-01

    degrees C), which is known to be neuroprotective [F.C. Barone, G.Z. Feuerstein, R.F. White, Brain cooling during transient focal ischaemia provides complete neuroprotection, Neurosci. Biobehav. Rev. 1, 1997, pp. 31-44; V.M. Bruno, M.P. Goldberg, L.L. Dugan, R.G. Giffard, D.W. Choi, Neuroprotective effect of hypothermia in cortical cultures exposed to oxygen glucose deprivation or excitatory aminoacids, J. Neurochem. 4, 1994, pp. 387-392; G.C. Newman, H. Qi, F.E. Hospod, K. Grundhmann, Preservation of hippocampal brain slices with in vivo or in vitro hypothermia, Brain Res. 1, 1992, pp. 159-163; J.Y. Yager, J. Asseline, Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic ischaemic brain damage in the immature rat, Stroke, 5, 1996, pp. 919-925.]. Low temperature incubation significantly reduced cell death, now being 9% at 24 h and 14% at 67 h. Our results show that these models of moderate mechanical trauma using organotypic slice cultures can be used to study neurodegeneration and neuroprotective strategies.

  18. Soil Materials and Health: An new experience for teaching

    Science.gov (United States)

    Del Hoyo Martínez, Carmen

    2014-05-01

    clays in the field of the health is a source to develop numerous studies of cases in the teaching of different subjects related to the geoscience and a new opportunity to connect the learning with the reality. References -Carretero, MI 2002. Clay Minerals and Their Beneficial Effects upon Human Health. A review. Appl. Clay Sci. 21, pp. 155-163. -Choy, J.H., Choi, S.J., Oh, J.M., Park, T. 2007. Clay minerals and layered double hydroxides for novel biological applications. Appl. Clay Sci. 36 pp. 122-132. -Del Hoyo, C. 2007. Layered double hydroxides and human health: An overview. Appl. Clay Sci. 36, pp. 103-121. -Lopez-Galindo, A., Viseras Iborra, C. & Cerezo Gonzalez, P. 2005. Arcillas y salud. In: Conferencias de la XIX Reunion de la Sociedad Espanola de Arcillas. Rives, Ed., pp. 15-18.

  19. Database of prompt gamma rays from slow neutron capture forelemental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, R.B.; Choi, H.D.; Lindstrom, R.M.; Molnar, G.L.; Mughabghab, S.F.; Paviotti-Corcuera, R.; Revay, Zs; Trkov, A.; Zhou,C.M.; Zerkin, V.

    2004-12-31

    analysis of complicated capture-gamma spectra by means ofPGAA. Therefore, the main goal of the CRP was to improve the quality andquantity of the required data in order to make possible the reliableapplication of PGAA in fields such as materials science, chemistry,geology, mining, archaeology, environment, food analysis and medicine.This aim wasachieved thanks to the dedicated work and effort of theparticipants. The CD-ROM included with this publication contains thedatabase, the retrieval system, the three CRM reports, and otherimportant electronic documents related to the CRP. The IAEA wishes tothanks all CRP participants who contributed to the success of the CRP andthe formulation of this publication. Special thanks are due to R.B.Firestone for his leading roll in the development of this CRP and hiscomprehensive compilation, analysis and provision of the adopteddatabase, and to V. Zerkin for the software developments associatedwiththe retrieval system. An essential component of this data compilation isthe extensive sets of new measurements of capture gamma-ray energies andintensities undertaken at Budapest by Zs. Revay under the direction ofG.L. Molnar. The extensive participation and assistance of H.D. Choi isalso greatly appreciated. Other participants inthis CRP were: R.M.Lindstrom, S.M. Mughabghab, A.V.R. Reddy, V.H. Tan and C.M. Zhou. Thanksare also due to S.C. Frankle and M.A. Lone for their active participationas consultants at some of the meetings. Finally, the participants wish tothank R. Paviotti-Corcuera (Nuclear Data Section, Division of Physicaland Chemical Sciences), who was the IAEA responsible officer for the CRP,this publication and the resulting database. The participants aregrateful to D.L. Muir and A.L. Nichols, successive Heads of the NuclearData Section, for their active and enthusiastic encouragement infurthering the work of the CRP.

  20. PREFACE: 13th International Conference on Electrorheological Fluids and Magnetorheological Suspensions (ERMR2012)

    Science.gov (United States)

    Unal, Halil Ibrahim

    2013-02-01

    China) gave plenary talks on novel MR shear thickening fluids, MR rubber composites and MR plastomers, respectively. H J Choi (INHA University, Korea), X Zhao (Northwestern Polytechnical University, China) and R Tao (Temple University, USA) delivered plenary lectures on issues relating to the area of electrorheological (ER) fluids. In their talks, Choi and Zhao covered novel ER materials with core-shell structured microspheres and micro/nano hierarchical structured titania particles, respectively, and Tao focused on the reduction of the viscosity of liquid suspensions for energy applications in transporting crude oil via pipelines. Attendance of the presentations was exceptionally high. Poster presentations were divided into two sessions and held in the afternoons after the close of the sessions, which were filled with stimulating discussions. The award for the best student research in the area of electrorheological fluids, sponsored by the Winslow family, was given to Y D Liu of INHA University, Korea on research entitled 'Copolyaniline coated monodisperse polystyrene microparticles and their electrorheological response'. The award for the best student research on magnetorheological suspensions, sponsored by the LORD Corporation, was given to S Kaneko of Keio University, Japan on research entitled 'Effect of a magnetic field on sloshing pressure in a magnetic fluid'. Besides the purely scientific program during the five days, some special events were also organized. A guided tour of the old city and some important landmarks of the capital city of Ankara were organized before the Gala Dinner. Special samples of Turkish classical music and folk dancing were performed by a group from the Republic of Turkey Ministry of Culture and Tourism to exhibit Turkish culture to the delegates at Gala Night, which was truly appreciated. Following the conclusion of this successful meeting, the next conference is expected to be organized at the University of Granada, Spain by Professor

  1. Welcome to the 2014 volume of Smart Materials and Structures

    Science.gov (United States)

    Garcia, Ephrahim

    2014-01-01

    last year after many years in service as Associate Editors. Associate Editors in 2013: Professor G Akhras, Royal Military College of Canada, Ontario, Canada Professor C Boller, University of Saarland, Saarbrücken, Germany Fraunhofer-Institut für Zerstörungsfreie Prüfverfahren, Dresden, Germany Professor J Cagnol, École Centrale Paris, France Professor G Carman, University of California-Los Angeles, USA Professor S-B Choi, Inha University, Incheon, Korea Professor S H Choi, NASA Langley Research Center, Hampton, VA, USA Professor A Del Grosso, Università degli Studi di Genova, Italy Professor A Erturk, Georgia Institute of Technology, GA, USA Professor U Gabbert, Universität Magdeburg, Germany Professor A Güemes, Universidad Politecnica de Madrid, Spain Professor S Gopalakrishnan, Indian Institute of Science, Bangalore, India Professor J Kim, Inha University, Incheon, Korea Professor K J Kim, University of Nevada, Reno, USA Professor S J Kim, Seoul National University, Korea Professor D Lagoudas, Texas A&M University, College Station, USA Professor R Lammering, Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Hamburg, Germany Professor C K Lee, National Taiwan University, Taiwan Professor W Li, University of Wollongong, Australia Professor W H Liao, Chinese University of Hong Kong, China Professor Y Liu, Harbin Institute of Technology, China Professor C S Lynch, University of California-Los Angeles, USA Professor S Masri, University of Southern California, Los Angeles, USA Professor W M Ostachowicz, Polish Academy of Sciences, Gdansk, Poland Professor K Peters, North Carolina State University, Raleigh, USA Professor M Shahinpoor, University of Maine, Orono, USA Professor H Sodano, University of Florida, Gainsville, USA Professor G Song, University of Houston, TX, USA Professor W J Staszewski, AGH University of Science and Technology, Kraków, Poland Professor N Takeda, University of Tokyo, Japan Professor D-H Wang, Chongqing University, China

  2. EDITORIAL: Welcome to the 2013 volume Welcome to the 2013 volume

    Science.gov (United States)

    Garcia, Ephrahim

    2013-01-01

    Professor Derek Abbott, Professor Alison Flatau, Professor Jinsong Leng and Professor Yuji Matsuzaki who have retired from the Board. Professor Matsuzaki worked on the journal for almost two decades. Associate Editors Professor G Akhras, Royal Military College of Canada, Ontario, Canada Professor C Boller, University of Saarland, Saarbrücken, Germany; Fraunhofer-Institut für Zerstörungsfreie Prüfverfahren, Dresden, Germany Professor Cagnol, École Centrale Paris, France Professor G Carman, University of California-Los Angeles, USA Professor S-B Choi, Inha University, Incheon, Korea Professor S H Choi, NASA Langley Research Center, Hampton, VA, USA Professor A Del Grosso, Università degli Studi di Genova, Italy Professor D Erickson, Cornell University, Ithaca, NY, USA Professor U Gabbert, Universität Magdeburg, Germany Professor A Güemes, Universidad Politecnica de Madrid, Spain Professor S Gopalakrishnan, Indian Institute of Science, Bangalore, India Professor J Kim, Inha University, Incheon, Korea Professor K J Kim, University of Nevada, Reno, USA Professor S J Kim, Seoul National University, Korea Professor D Lagoudas, Texas A&M University, College Station, USA Professor R Lammering, Helmut-Schmidt-Universität/Universität der Bundeswehr Hamburg, Hamburg, Germany Professor C K Lee, National Taiwan University, Taiwan Professor W Li, University of Wollongong, Australia Professor W H Liao, Chinese University of Hong Kong, China Professor Y Liu, Harbin Institute of Technology, China Professor C S Lynch, University of California-Los Angeles, USA Professor S Masri, University of Southern California, Los Angeles, USA Professor W M Ostachowicz, Polish Academy of Sciences, Gdansk, Poland Professor K Peters, North Carolina State University, Raleigh, USA Professor M Shahinpoor, University of New Mexico, Albuquerque, USA Professor H Sodano, Arizona State University, Tempe, USA Professor G Song, University of Houston, TX, USA Professor W J Staszewski, AGH University of Science

  3. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Pulmonology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    STRATEGY? • K. Swamy, C. Smith, A. Wynn-Davies, N. SinghABS 29. ACCURACY OF TRANSCUTANEOUS MEASUREMENT OF CO2 IN NEONATES • G. Magyarová, M. Kovácsová, E. Radvanská, H. KoňošováABS 30. NASAL INTERMITTENT POSITIVE PRESSURE VENTILATION VERSUS BI-LEVEL NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE FOLLOWING EXTUBATION IN INFANTS < 1,250 G BIRTHWEIGHT: PRELIMINARY REPORT • N. Okur, M. Buyuktiryaki, F.N. Sari, E. Dizdar, N. Uras, F. Canpolat, S.S. OguzABS 31. TRENDS IN NEONATAL RESPIRATORY SUPPORT IN THE AUSTRALIAN & NEW ZEALAND NEONATAL NETWORK (ANZNN 2009-2012 • C. Roberts, B. Manley, L. Owen, P. Davis, for the ANZNNABS 32. WEANING OF NASAL CPAP IN SCANDINAVIA • H. Bergseng, M. Elden, I.S. Hjort, R. StoenABS 33. A PROSPECTIVE RANDOMIZED, CONTROLLED TRIAL COMPARING HUMIDIFIED HIGH FLOW NASAL CANNULA VERSUS NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE AS RESPIRATORY SUPPORTS AFTER EXTUBATION IN PRETERM INFANTS • E.H. Lee, J. Shin, Y.S. Kim, B.M. ChoiABS 34. LEAKAGE DURING NONINVASIVE HIGH FREQUENCY OSCILLATORY VENTILATION IMPROVES CARBON DIOXIDE CLEARANCE IN A NEONATAL LUNG MODEL • D. Klotz, D. Stavropoulou, C. Schäfer, R. Hentschel, S. Schumann, H. FuchsABS 35. HIGH FLOW SUPPORT IN VERY PRETERM INFANTS WITHIN THE AUSTRALIAN & NEW ZEALAND NEONATAL NETWORK (ANZNN 2009-2012 • C. Roberts, L. Owen, B. Manley, P. Davis, for the ANZNNABS 36. IMPACT OF NASAL PRONG RESISTANCE ON PRESSURE DELIVERY DURING NON-INVASIVE VENTILATION WITH FIXED AND VARIABLE FLOW USING A PNEUMATIC LUNG MODEL • A. Maturana, F. Cavigioli, A. Aliverti, C. Mendez, G. ListaABS 37. COMPARISON OF EXTUBATION FAILURE IN NIV-NAVA AND nCPAP FOR PRETERM INFANTS • B.K. Lee, H.-R. Kim, Y.H. Jung, S.H. Shin, C.W. Choi, E.-K. Kim, H.-S. Kim,  B.I. Kim, J.-H. ChoiABS 38. A RANDOMIZED TRIAL OF LOW FLOW OXYGEN VERSUS NASAL CPAP IN PRETERM INFANTS • C. Heiring, J. Steensberg, M. Bjerager, G. GreisenABS 39. SHEDDING LIGHT ON PRETERM IMMUNITY • J.C. Lao, F. Beker, K. König, E. Noble, G. Walsh, A

  4. Advanced Materials and Processing 2010

    Science.gov (United States)

    Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

    2011-06-01

    Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

  5. ITER ITA newsletter. No. 24, July 2005

    International Nuclear Information System (INIS)

    2005-08-01

    stimulant for international co-operation on science and technology in the twenty first century, and taking a broader view of the situation, Japan has decided that they will let the EU host the ITER site. Dr. J. Potocnik, European Commissioner for Science and Research, thanked Minister Nakayama for the highly constructive spirit with which he and his colleagues had conducted the bilateral discussions. He expressed his respect for the honourable manner in which the most sensitive stages were handled. He pointed out that the EU was well aware of the important task it had in front of it as the Host of ITER. The action taken had implications beyond that of establishing fusion energy. It was also an expression of mutual confidence to face the scientific, technical and political challenges that will occur in the course of this first-of-a-kind true international science cooperation among the leading nations of the world. ITER was establishing a model of global co-operation to address the increasingly global nature of the challenges confronting today's society. The Chinese Minister of Science and Technology, Mr. Xu Guanhua, expressed his pleasure that agreement on the site had been found within the six-Party framework. China considered that a sustainable solution to the world's energy source problem required multilateral international collaboration on fusion, so that participants could complement each other's skills and pool resources in the shared challenge. Mr. S. Choi, Vice-Minister of Science and Technology, Republic of Korea, reminded the delegates that the eyes of the world were on ITER as one of the most significant projects of the century, with a view to it being a peaceful and affluent one. Having just crossed the barrier of the site decision, there was still more to be done ahead, particularly by concluding the ITER Joint Implementation Agreement as soon as possible. He quoted a Korean proverb, literally translated as 'After rain ground hardens', which parallels with the

  6. Comparison of hydration and nutritional status between young and elderly hemodialysis patients through bioimpedance analysis

    Directory of Open Access Journals (Sweden)

    Lee JE

    2015-08-01

    Full Text Available Jung Eun Lee,1,2 In Young Jo,3 Song Mi Lee,3 Woo Jeong Kim,3 Hoon Young Choi,2,4 Sung Kyu Ha,4 Hyung Jong Kim,5 Hyeong Cheon Park2,4 1Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 2Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, 3Department of Nutrition Services, Gangnam Severance Hospital, 4Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, 5Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea Background: The number of elderly people on dialysis is increasing rapidly. Fluid overload and malnutrition status are serious problems in elderly dialysis patients. We aimed to compare the hydration and nutritional status through bioimpedance analysis (BIA between young and elderly hemodialysis (HD patients and to analyze risk factors related to fluid overload and malnutrition status in these patients.Method: We conducted a cross-sectional study, in which 82 HD (males 42, mean age 58.7±12.9 years patients were enrolled. We collected different types of data: laboratory data, such as serum creatinine, albumin, total iron-binding capacity, hemoglobin, total cholesterol; anthropometric data, such as hand grip strength (HGS; BIA data, such as intracellular water, skeletal muscle mass, body cell mass, bone mineral content, phase angle (PhA, extra cellular water (ECW/total body water (TBW ratio; and malnutrition-inflammation score (MIS, which is a traditional nutritional parameter for dialysis patients. All patients were stratified into two groups according to their age: young (<65 years [n=54] and elderly (≥65 years [n=28].Results: Total iron-binding capacity and HGS were significantly lower in elderly HD patients than in young HD patients (198.9±35.6 vs 221.4±52.1 mcg/dL; and 22.4±10.3 vs 36.4±23.2 kg, respectively (P<0.05. Also, intracellular water and Ph

  7. EDITORIAL: Nanowires for energy Nanowires for energy

    Science.gov (United States)

    LaPierre, Ray; Sunkara, Mahendra

    2012-05-01

    dominant lighting technology due to its superior electrical to optical conversion efficiency. A unique LED structure based on CdS is presented by Ye et al [8]. A detailed study by Nguyen et al [9] provides a fundamental understanding of the non-radiative recombination mechanisms in GaN-based white light emitting nanowire diodes grown on Si substrates. Another application of III-nitrides is in photovoltaic devices (solar cells) [10]. InGaN is the only semiconductor alloy whose energy bandgap can be continuously varied across nearly the entire solar spectrum, promising a new generation of solar cells. Another potentially important application for nanowires is the efficient production of H2 from the photocatalytic splitting of water, where the H2 can be used as an energy carrier. Water splitting based on unique nanostructures include Fe2O3 [11], CuS/ZnO [12], and ZnO/Si [13]. Another candidate for photocatalysis, among other applications, is copper oxide nanowires, reviewed by Gregor et al [14]. References [1] Hiralal P, Unalan H E and Amaratunga G A J 2012 Nanotechnology 23 194002 [2] Li J, Yu H and Li Y 2012 Nanotechnology 23 194010 [3] Wang B and Leu P W 2012 Nanotechnology 23 194003 [4] Yu L, O'Donnell B, Foldyna M, and Roca i Cabarrocas P 2012 Nanotechnology 23 194011 [5] Zhang F, Song T and Sun B 2012 Nanotechnology 23 194006 [6] Herman I, Yeo J, Hong S, Lee D, Nam K H, Choi J, Hong W, Lee D, Grigoropoulos C P and Ko S H 2012 Nanotechnology 23 194005 [7] Calestani D, Pattini F, Bissoli F, Gilioli E, Villani M and Zappettini A 2012 Nanotechnology 23 194008 [8] Ye Y, Yu B, Gao Z, Mang H, Zhang H, Dai L and Qin G 2012 Nanotechnology 23 194004 [9] Nguyen H P T, Djavid M, Cui K and Mi Z 2012 Nanotechnology 23 194012 [10] Wierer J J Jr, Li Q, Koleske D D, Lee S R L and Wang G T 2012 Nanotechnology 23 194007 [11] Chernomordik B D, Russell H B, Cvelbar U, Jasinski J B, Kumar V, Deutsch T and Sunkara M K 2012 Nanotechnology 23 194009 [12] Lee M and Yong K 2012 Nanotechnology 23

  8. Recording, Visualization and Documentation of 3D Spatial Data for Monitoring Topography in Areas of Cultural Heritage

    Science.gov (United States)

    Maravelakis, Emmanouel; Konstantaras, Antonios; Axaridou, Anastasia; Chrysakis, Ioannis; Xinogalos, Michalis

    2014-05-01

    . Journal of Archaeological Science 40, 176-189 (2012) [6] Sinclair, P., Addis, M., Choi, F., Doerr, M., Lewis, P., Martinez, K.: The Use of CRM Core in Multimedia Annotation. In: First International Workshop on Semantic Web Annotations for Multimedia (2006) [7] Zhiming, Z., et al.: Scientific workflow management: between generality and applicability. In: Proc. the 5th International Conference on Quality Software, Melbourne, Australia, pp. 19-20 (2005) [8] Infrastructure for Spatial Information in Europe. INSPIRE Architecture and Standards Position Paper (2002) [9] Doerr, M., Kritsotaki, A.: Documenting events in metadata. In: The e-volution of Information Communication Technology in Cultural Heritage, pp. 56-61 (2006) [10] Maravelakis, E., Konstantaras, A., Kritsotaki, A., Angelakis, D. and Xinogalos, M.: Analysing User Needs for a Unified 3D Metadata Recording and Exploitation of Cultural Heritage Monuments System, Advances in Visual Computing, Lecture Notes in Computer Science Volume 8034, pp 138-147, (2013) [11] Maravelakis, E., Andrianakis, M., Psarakis, K., Bolanakis, N., Tzatzanis, G., Bilalis, N., Antoniadis, A.: Lessons Learned from Cultural Heritage Digitisation Projects in Crete. In: Proceedings of the 14th International Conference on Virtual Systems and Multimedia, pp. 152-156 (2008)

  9. Message from the Editor

    Science.gov (United States)

    Stambaugh, Ronald D.

    2014-01-01

    thank the following outgoing Board Members whose term of service was reached at the end of 2012: Keith Burrell, Atsushi Fukuyama, Guenter Janeschitz, Myeun Kwon, Alberto Loarte, Derek Stork, Tony Taylor and Kazuo Toi. We welcome the new Board Members who have joined the Board from the start of 2013: Pietro Barabaschi, Riccardo Betti, Rich Callis, Wonho Choi, Yasuaki Kishimoto, Joaquin Sánchez, Paul Thomas, Mickey Wade, Howard Wilson, Hiroshi Yamada and Steve Zinkle. We look forward to working with the Board to maintain the high standing of Nuclear Fusion . The Nuclear Fusion office and IOP Publishing Just as the journal depends on the authors, referees, and Board of Editors, so its success is also due to the tireless and largely unsung efforts of the IAEA Nuclear Fusion office in Vienna and IOP Publishing in Bristol. I would like to express my personal thanks to the team for the support that they have given to me, the authors and the referees. Season's greetings I would like to wish our readers, authors, referees, Board of Editors, and Vienna and Bristol office staff season's greetings and thank them for their contributions to Nuclear Fusion in 2013. References [1] Whyte D.G. et al 2010 I-mode: an H-mode energy confinement regime with L-mode particle transport in Alcator C-Mod Nucl. Fusion 50 105005 [2] Bosch H.-S. et al 2013 Technical challenges in the construction of the steady-state stellarator Wendelstein 7-X Nucl. Fusion 53 126001 [3] Chapman I.T. et al 2013 Power requirements for electron cyclotron current drive and ion cyclotron resonance heating for sawtooth control in ITER Nucl. Fusion 53 066001 [4] Knaster J. et al 2013 IFMIF: overview of the validation activities Nucl. Fusion 53 116001

  10. Editorial: Focus on Atom Optics and its Applications

    Science.gov (United States)

    Schmidt-Kaler, F.; Pfau, T.; Schmelcher, P.; Schleich, W.

    2010-06-01

    Couvert, B Georgeot and D Guéry-Odelin Analysis of the entanglement between two individual atoms using global Raman rotations A Gaëtan, C Evellin, J Wolters, P Grangier, T Wilk and A Browaeys Spin polarization transfer in ground and metastable helium atom collisions D Vrinceanu and H R Sadeghpour A fiber Fabry-Perot cavity with high finesse D Hunger, T Steinmetz, Y Colombe, C Deutsch, T W Hänsch and J Reichel Atomic wave packets in amplitude-modulated vertical optical lattices A Alberti, G Ferrari, V V Ivanov, M L Chiofalo and G M Tino Atom interferometry with trapped Bose-Einstein condensates: impact of atom-atom interactions Julian Grond, Ulrich Hohenester, Igor Mazets and Jörg Schmiedmayer Storage of protonated water clusters in a biplanar multipole rf trap C Greve, M Kröner, S Trippel, P Woias, R Wester and M Weidemüller Single-atom detection on a chip: from realization to application A Stibor, H Bender, S Kühnhold, J Fortágh, C Zimmermann and A Günther Ultracold atoms as a target: absolute scattering cross-section measurements P Würtz, T Gericke, A Vogler and H Ott Entanglement-assisted atomic clock beyond the projection noise limit Anne Louchet-Chauvet, Jürgen Appel, Jelmer J Renema, Daniel Oblak, Niels Kjaergaard and Eugene S Polzik Towards the realization of atom trap trace analysis for 39Ar J Welte, F Ritterbusch, I Steinke, M Henrich, W Aeschbach-Hertig and M K Oberthaler Resonant superfluidity in an optical lattice I Titvinidze, M Snoek and W Hofstetter Interference of interacting matter waves Mattias Gustavsson, Elmar Haller, Manfred J Mark, Johann G Danzl, Russell Hart, Andrew J Daley and Hanns-Christoph Nägerl Magnetic trapping of NH molecules with 20 s lifetimes E Tsikata, W C Campbell, M T Hummon, H-I Lu and J M Doyle Imprinting patterns of neutral atoms in an optical lattice using magnetic resonance techniques Michal Karski, Leonid Förster, Jai-Min Choi, Andreas Steffen, Noomen Belmechri, Wolfgang Alt, Dieter Meschede and Artur Widera

  11. Silicate Inclusions in IAB Irons: Correlations Between Metal Composition and Inclusion Properties, and Inferences for Their Origin

    Science.gov (United States)

    Benedix, G. K.; McCoy, T. J.; Keil, K.

    1995-09-01

    changes observed here indicate that the silicates were interacting with a single evolving metallic magma. We suggest that the requirement for a common system is more compatible with core formation [5,6] than with impact-melt pools [2,4]. References: [1] McCoy T. J. et al. (1993) Meteoritics, 28, 552-560. [2] Choi B.-G. et al. (1995) GCA, 59, 593-612. [3] Benedix G. K. et al. (1995) LPS XXVI, 99-100. [4] Wasson J. T. et al. (1980) Z. Naturforsch., 35a, 781-795. [5] Kracher A. (1982) GRL, 9, 412-415. [6] Kracher A. (1985) Proc. LPSC 15th, in JGR, 90, C689-C698. [7] Bunch T. E. et al. (1970) Contrib. Mineral. Petrol., 25, 297-340. [8] McCoy et al. (1995) Meteoritics, in preparation. [9] Scott E. R. D. and Bild R. W. (1974) GCA, 38, 1379-1391. [10] Takeda H. et al. (1993) Meteoritics, 28, 447.

  12. Committees

    Science.gov (United States)

    2012-11-01

    Quebec IREQ, Varennes Canada Etienne PARKINSON Andritz Hydro Ltd. Switzerland B V S S S PRASAD Indian Institute of Technology Madras India Stefan RIEDELBAUCH Stuttgart University Germany Michel SABOURIN Alstom Hydro Canada Inc Canada Bruno SCHIAVELLO Flowserve Corporation USA Katsumasa SHIMMEI Hitachi Ltd Japan Christoph SINGRTüN VDMA Germany Ale? SKOTAK CKD Blansko Engineering, a s Czech Republic Toshiaki SUZUKI Toshiba Corporation Japan Andy C C TAN Queensland University of Technology Australia Geraldo TIAGO FILHO Universidade Federal de Itajuba Brazi Thi C VU Andritz Hydro Ltd Canada Satoshi WATANABE Kyushu University Japan S H WINOTO National University of Singapore Singapore Woo-Seong WOO STX Institute of Technology Korea International Technical Committee François AVELLAN (principal) EPFL-LMH Switzerland Xingqi LUO (principal) Xi'an University of Technology China Martin BÖHLE Kaiserslautern University Germany Gerard BOIS ENSAM France Young-Seok CHOI KITECH Korea Luca d'AGOSTINO University of Pisa Italy Eduard EGUSQUIZA Polytechnical University Catalonia Spain Arpad FAY University of Miskolcz Hungary Richard FISHER Voith Hydro Inc USA Regiane FORTES-PATELLA Institute Polytechnique de Grenoble France Aleksandar GAJIC University of Belgrade Serbia José GONZÁLEZ Universidad de Oviedo Spain François GUIBAULT Ecole Polytechnique de Montreal Canada Toshiaki IKOHAGI Tohoku University Japan Chisachi KATO University of Tokyo Japan Kwang-Yong KIM Inha University Korea Youn-Jea KIM Sungkyunkwan University Korea Smaine KOUIDRI Université Pierre et Marie Curie (Paris 6) France Shengcai LI Warwick University UK Adrian LUNGU Dunarea de Jos University of Galati Romania Torbjøm K NIELSEN NTNU Norway Michihiro NISHI Tsinghua University China Peter PELZ Darmstadt University Germany Frantisek POCHYLY Brno University Czech Republic Albert RUPRECHT University of Stuttgart Germany Rudolf SCHILLING Technische University München Germany Wei SHYY HKUST Hong Kong,China Romeo SUSAN

  13. Solid State Ionics Advanced Materials for Emerging Technologies

    Science.gov (United States)

    Chowdari, B. V. R.; Careem, M. A.; Dissanayake, M. A. K. L.; Rajapakse, R. M. G.; Seneviratne, V. A.

    2006-06-01

    spectroscopic analysis of thin film LiNiVO[symbol] prepared by pulsed laser deposition technique / S. Selvasekarapandian ... [et al.]. Synthesis and characterization of LiFePO[symbol] cathode materials by microwave processing / J. Zhou ... [et al.]. Characterization of Nd[symbol]Sr[symbol]CoO[symbol] including Pt second phase as the cathode material for low-temperature SOFCs / J. W. Choi ... [et al.]. Thermodynamic behavior of lithium intercalation into natural vein and synthetic graphite / N. W. B. Balasooriya, P. W. S. K. Bandaranayake, Ph. Touzain -- pt. III. Electroactive polymers. Invited papers. Organised or disorganised? looking at polymer electrolytes from both points of view / Y.-P. Liao ... [et al.]. Polymer electrolytes - simple low permittivity solutions? / I. Albinsson, B.-E. Mellander. Dependence of conductivity enhancement on the dielectric constant of the dispersoid in polymer-ferroelectric composite electrolytes / A. Chandra, P. K. Singh, S. Chandra. Design and application of boron compounds for high-performance polymer electrolytes / T. Fujinami. Structural, vibrational and AC impedance analysis of nano composite polymer electrolytes based on PVAC / S. Selvasekarapandian ... [et al.]. Absorption intensity variation with ion association in PEO based electrolytes / J. E. Furneaux ... [et al.]. Study of ion-polymer interactions in cationic and anionic ionomers from the dependence of conductivity on pressure and temperature / M. Duclot ... [et al.]. Triol based polyurethane gel electrolytes for electrochemical devices / A. R. Kulkarni. Contributed papers. Accurate conductivity measurements to solvation energies in nafion / M. Maréchal, J.-L Souquet. Ion conducting behaviour of composite polymer gel electrolyte: PEG-PVA-(NH[symbol]CH[symbol]CO[symbol])[symbol] system / S. L. Agrawal, A. Awadhia, S. K. Patel. Impedance spectroscopy and DSC studies of poly(vinylalcohol)/ silicotungstic acid crosslinked composite membranes / A. Anis, A. K. Banthia. (PEO

  14. EDITORIAL: Excelling under strain: band engineering in nanomaterials Excelling under strain: band engineering in nanomaterials

    Science.gov (United States)

    Demming, Anna

    2013-08-01

    J-C 2011 Strain engineering of thermal conductivity in graphene sheets and nanoribbons: a demonstration of magic flexibility Nanotechnology 22 105705 [6]Berbezier I, Ronda A and Portavoce A 2002 SiGe nanostructures: new insights into growth processes J. Phys.: Condens. Matter 14 8283 [7] Kim J H, Moon S R, Kim Y, Chen Z G, Zou J, Choi D Y, Joyce H J, Gao Q, Tan H H and Jagadish C 2012 Taper-free and kinked germanium nanowires grown on silicon via purging and the two-temperature process Nanotechnology 23 115603 [8] Steve G 1993 Theorizing Modernism: Essays in Critical Theory (Routledge: Talyor and Francis) p 28

  15. EDITORIAL: Non-volatile memory based on nanostructures Non-volatile memory based on nanostructures

    Science.gov (United States)

    Kalinin, Sergei; Yang, J. Joshua; Demming, Anna

    2011-06-01

    barrier width in tunnelling experiments, resulting in memristive ionic switching. These phenomena must be differentiated from intrinsic physical polarization switching effects. Similar analysis of solid-state electrochemistry versus physical mechanisms is also important for future research in all areas of oxide materials. In an age where miniaturised computer components can enable GPS tracking, internet access and even the remote operation of machinery from a mobile phone, there is an endearing quaintness associated with images of the large rooms rammed with wires and boxes that comprised early computers. Yet there was a time when these cumbersome devices were state of the art. When the electronic numerical integrator and computer (ENIAC) was developed it achieved speeds one thousand times faster than previous electromechanical machines, a leap in processing power that has not been achieved since. It is easy to imagine future generations looking back on the slow start up and shut down times and high energy consumption of today's computers with a similar wry smile. The articles in this special issue on non-volatile memory based on nanostructures present the very latest research into the next generation's device technology, which may eventually consign today's cutting edge electronics to the history books. References [1] Ryu S W et al 2011 Nanotechnology 22 254005 [2] Miao F, Yang J J, Borghetti J, Medeiros-Ribeiro G and Williams R S 2011 Nanotechnology 22 254007 [3] Strachan J P, Strukov D B, Borghetti J, Yang J J, Medeiros-Ribeiro G and Williams R S 2011 Nanotechnology 22 245015 [4] Kim K M, Choi B J, Lee M H, Kim G H, Song S J, Seok J Y, Yoon J H, Han S and Hwang C S 2011 Nanotechnology 22 254010 [5] Seo K et al 2011 Nanotechnology 22 254023 [6] Garcia V, Fusil S, Bouzehouane K, Enouz-Vedrenne S, Mathur N D, Barthelemy A and Bibes M 2009 Nature 460 81-4 [7] Maksymovych P, Jesse S, Yu P, Ramesh R, Baddorf A P and Kalinin S V 2009 Science 324 1421 [8] Seidel J et al 2009

  16. Watt and joule balances

    Science.gov (United States)

    Robinson, Ian A.

    2014-04-01

    balance group are in the initial phases of the design and construction of a watt balance and their paper provides valuable information on the design that they are building. The design of the main magnet of a watt balance is critical to its successful operation, and an important assumption of watt balance operation is that the field of the magnet in moving mode is equivalent to that in weighing mode. Sutton and Clarkson from MSL describe a novel magnet which is designed to address this issue. The international prototype of the kilogram is kept in air but, after redefinition, the best realizations of the mass unit will be in vacuum. In their paper Berry and Davidson from NPL describe progress in techniques which relate mass measured in vacuum to that measured in air. Such techniques will be essential for making the results of watt and joule balance measurements available to science and industry. Both the NIST and NPL Mark II (NRC) watt balances use knife edges to act as the pivots for the beam. Knife edges suffer from hysteresis which can produce systematic offsets during weighing. In their paper Choi (KRISS) and Robinson (NPL) describe the analysis of this problem using both finite element (FEM) techniques and a stand-alone balance designed for testing knife edges. The last two papers deal with the possible future of the watt balance technique. The BIPM simultaneous measurement scheme for the watt balance was originally conceived for operation at cryogenic temperatures with a superconducting coil. In their paper de Mirandes and her co-authors describe initial work on the principles of this superconducting variant of the BIPM watt balance and concentrate on the characteristics of the superconducting coil in comparison with those of a normal coil. The final paper is a good example of serendipity in which Kibble (Independent Consultant) was designing novel watt balances based on seismometer suspensions and Robinson (NPL) had derived a set of general expressions, which are

  17. Studies on the Utilization, Metabolism and Function of Sterols in the House-Fly, Musca Domestica; Utilisation. Metabolisme et fonctions des sterols chez la mouche domestique (Musca Domestica); Izuchenie usvoeniya, metabolizma i funktsii sterinov v organizme domashnej mukhi Musca Domestica; Estudios sobre la asimilacion, el metabolismo y la funcion de los esteroles in la mosca comun (Musca Domestica)

    Energy Technology Data Exchange (ETDEWEB)

    Robbins, W. E. [United States Department of Agriculture, Agricultural Research Service, Entomology Research Division, Beltsville, MD (United States)

    1963-09-15

    Insects generally have been found to require a dietary source of sterol for normal larval growth and metamorphosis. Our work has pointed to two additional physiological roles for sterols in the housefly, Musca domestica L.: (1) A dietary source of sterol is essential for sustained viable egg production in the female fly; on a sterol-deficient diet eggs are produced but hatch and viability are low. (2) Cholesterol is also involved in the mobilization and utilization of nutrient reserves associated with the initiation of ovarian maturation in the female fly. The quantitative sterol requirements for the above physiological processes and the metabolic conversions that occur during growth, metamorphosis and reproduction have been studied in this insect, using C{sup 14}- and H{sup 3}-labelled sterols in conjunction with a variety of analytical tools, including reverse isotope dilution, gasliquid chromatography and spectroscopy, and employing aseptic rearing techniques and semi-defined larval and Adult diets. Both C{sup 14}-cholesterol and H{sup 3}-{beta}- sitosterol have been used as a source df sterol in either the larval or the adult diet of the house fly, and the pattern of utilization and metabolism was found to be almost identical for these two sterols. However, there was no detectable conversion of {beta}-sitosterol to cholesterol. Sub-minimal quantities of cholesterol have also been used in the larval diet in combination with ''sparing sterols'' such as choies tanol, which will fulfill in part but not entirely the sterol requirement of this insect. The utilization and fate of the 'sparing sterol' has been investigated using C{sup 14} cholestanol, and the metabolism of the minute quantity of essential cholesterol is currently under study using high-specific-activity C{sup 14} cholesterol. - Other species of insects, including the German cockroach (Blattella germanica), have been examined in relation to the patterns of utilization and the metabolic pathways for

  18. 12th WINFOCUS world congress on ultrasound in emergency and critical care.

    Science.gov (United States)

    Acar, Yahya; Tezel, Onur; Salman, Necati; Cevik, Erdem; Algaba-Montes, Margarita; Oviedo-García, Alberto; Patricio-Bordomás, Mayra; Mahmoud, Mustafa Z; Sulieman, Abdelmoneim; Ali, Abbas; Mustafa, Alrayah; Abdelrahman, Ihab; Bahar, Mustafa; Ali, Osama; Lester Kirchner, H; Prosen, Gregor; Anzic, Ajda; Leeson, Paul; Bahreini, Maryam; Rasooli, Fatemeh; Hosseinnejad, Houman; Blecher, Gabriel; Meek, Robert; Egerton-Warburton, Diana; Ćuti, Edina Ćatić; Belina, Stanko; Vančina, Tihomir; Kovačević, Idriz; Rustemović, Nadan; Chang, Ikwan; Lee, Jin Hee; Kwak, Young Ho; Kim, Do Kyun; Cheng, Chi-Yung; Pan, Hsiu-Yung; Kung, Chia-Te; Ćurčić, Ela; Pritišanac, Ena; Planinc, Ivo; Medić, Marijana Grgić; Radonić, Radovan; Fasina, Abiola; Dean, Anthony J; Panebianco, Nova L; Henwood, Patricia S; Fochi, Oliviero; Favarato, Moreno; Bonanomi, Ezio; Tomić, Ivan; Ha, Youngrock; Toh, Hongchuen; Harmon, Elizabeth; Chan, Wilma; Baston, Cameron; Morrison, Gail; Shofer, Frances; Hua, Angela; Kim, Sharon; Tsung, James; Gunaydin, Isa; Kekec, Zeynep; Ay, Mehmet Oguzhan; Kim, Jinjoo; Kim, Jinhyun; Choi, Gyoosung; Shim, Dowon; Lee, Ji-Han; Ambrozic, Jana; Prokselj, Katja; Lucovnik, Miha; Simenc, Gabrijela Brzan; Mačiulienė, Asta; Maleckas, Almantas; Kriščiukaitis, Algimantas; Mačiulis, Vytautas; Macas, Andrius; Mohite, Sharad; Narancsik, Zoltan; Možina, Hugon; Nikolić, Sara; Hansel, Jan; Petrovčič, Rok; Mršić, Una; Orlob, Simon; Lerchbaumer, Markus; Schönegger, Niklas; Kaufmann, Reinhard; Pan, Chun-I; Wu, Chien-Hung; Pasquale, Sarah; Doniger, Stephanie J; Yellin, Sharon; Chiricolo, Gerardo; Potisek, Maja; Drnovšek, Borut; Leskovar, Boštjan; Robinson, Kristine; Kraft, Clara; Moser, Benjamin; Davis, Stephen; Layman, Shelley; Sayeed, Yusef; Minardi, Joseph; Pasic, Irmina Sefic; Dzananovic, Amra; Pasic, Anes; Zubovic, Sandra Vegar; Hauptman, Ana Godan; Brajkovic, Ana Vujaklija; Babel, Jaksa; Peklic, Marina; Radonic, Vedran; Bielen, Luka; Ming, Peh Wee; Yezid, Nur Hafiza; Mohammed, Fatahul Laham; Huda, Zainal Abidin; Ismail, Wan Nasarudin Wan; Isa, W Yus Haniff W; Fauzi, Hashairi; Seeva, Praveena; Mazlan, Mohd Zulfakar

    2016-09-01

    Jinjoo Kim, Jinhyun Kim, Gyoosung Choi, Dowon ShimA27 Usefulness of abdominal ultrasound for acute pyelonephritis diagnosis after kidney transplantationJi-Han LeeA28 Lung ultrasound for assessing fluid tolerance in severe preeclampsiaJana Ambrozic, Katja Prokselj, Miha LucovnikA29 Optic nerve sheath ultrasound in severe preeclampsiaGabrijela Brzan Simenc, Jana Ambrozic, Miha LucovnikA30 Focused echocardiography monitoring in the postoperative period for non-cardiac patientsAsta Mačiulienė, Almantas Maleckas, Algimantas Kriščiukaitis, Vytautas Mačiulis, Andrius MacasA31 POCUS-guided paediatric upper limb fracture reduction: algorithm, tricks, and tipsSharad MohiteA32 Point-of-care lung ultrasound: a good diagnostic tool for pneumonia in a septic patientZoltan Narancsik, Hugon MožinaA33 A case of undergraduate POCUS (r)evolutionSara Nikolić, Jan Hansel, Rok Petrovčič, Una Mršić, Gregor ProsenA34 The Graz Summer School for ultrasound: from first contact to bedside application: three-and-a-half-day undergraduate ultrasound training: résumé after two years of continuous developmentSimon Orlob, Markus Lerchbaumer, Niklas Schönegger, Reinhard KaufmannA35 Usefulness of point-of-care ultrasound in the emergency room in a patient with acute abdominal painAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA36 Use of bedside ultrasound in a critically ill patient. A case reportAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA37 Diagnostic yield of clinical echocardiography for the emergency physicianAlberto Oviedo-García, Margarita Algaba-Montes, Mayra Patricio-BordomásA38 Focused cardiac ultrasound in early diagnosis of type A aortic dissection with atypical presentationChun-I Pan, Hsiu-Yung Pan, Chien-Hung WuA39 Detection of imperforated hymen by point-of-care ultrasoundHsiu-yung Pan, Chia-Te KungA40 Developing a point-of-care ultrasound curriculum for pediatric nurse practitioners practicing in the pediatric emergency

  19. Selected Abstracts of the 6th International Congress of UENPS; Valencia (Spain; November 23rd-25th 2016; Session “Brain and development”

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2016-11-01

    . Sancho-MonteroABS 12. ASSESSMENT OF SLEEP IN INFANTS DURING THE FIRST SIX MONTHS OF LIFE • M. Zornoza-Moreno, S. Fuentes-Hernández, J.A. Madrid, E. LarquéABS 13. RING 18: CLINICAL CASE • P. Mendes, P. Cruz, M. Anselmo, L. GonçalvesABS 14. REGIONAL SOMATIC OXIMETRY IN NEONATES OF DIFFERENT GESTATIONAL AGE IN NICU • V. Abalova, O. Grebennikova, A. Zavadenko, MV. Degtyareva, S. Rogatkin, MG. DegtyarevaABS 15. NEWBORN WITH ARACHNOID CYST – CASE REPORT • M. Jonovic1, B. Miljkovic, N. Stojanovic, S. Stamenovic, G. Jovanovic, T. TosicABS 16. PROGNOSTIC VALUE OF APPARENT DIFFUSION COEFFICIENT VALUES IN NEWBORNS WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY TREATED WITH THERAPEUTIC HYPOTHERMIA • I. Benavente-Fernandez, S.P. Lubián-López, E.M. Heursen, R. Campuzano Fernandez-Colina, G. Jiménez-Gómez, A. Zuazo-OjedaABS 17. PROGNOSTIC VALUE OF DIFFUSION-WEIGHTED IMAGING IN NEWBORNS WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY TREATED WITH THERAPEUTIC HYPOTHERMIA • I. Benavente-Fernandez, S.P. Lubián-López, E.M. Heursen, R. Campuzano Fernandez-Colina, G. Jiménez-Gómez, A. Zuazo-OjedaABS 18. FETAL-TO-NEONATAL TRANSITION UNDER HYPOXIC ATMOSPHERE IN BRAIN • I. Torres-Cuevas, J. Escobar, E. Cubells, R. Rodrigo, J.M. Garcia-Verdugo, M. VentoABS 19. NORMAL MRI IN CHILDREN FROM THE PORTUGUESE CEREBRAL PALSY REGISTRY • D. Virella, T. Folha, A. Cadete, M.G. Andrada, C. Conceição, R. Gouveia, J. Alvarelhão, E. CaladoABS 20. A FAMILY CASE OF DISTAL 22Q11.2 MICRODUPLICATION • L. Domingo, M.J. Rivero, S. de las Heras, D. Montes, B. García, M. Cuadrado, L. LlorenteABS 21. THE CORRELATION BETWEEN NEONATAL FACTORS AND SUBJECTIVE SCORES OF THE BAYLEY SCALES OF INFANT DEVELOPMENT-III IN PREMATURE INFANTS • E.K. Choi, H.W. Kim, I.G. Song, Y.H. Jung, S.H. Shin, E.K. Kim, H.S. KimABS 22. DECREASED CEREBRAL GLUCOSE METABOLISM USING F-18 FDG BRAIN PET/CT IN VERY LOW BIRTH WEIGHT INFANTS WITHOUT STRUCTURAL ABNORMALITY ON BRAIN MRI • J.H. Park, C.S. Kim, S.L. Lee, H.W. Kim, H.J. Lee

  20. EDITORIAL: Focus on Dilute Magnetic Semiconductors FOCUS ON DILUTE MAGNETIC SEMICONDUCTORS

    Science.gov (United States)

    Chambers, Scott A.; Gallagher, Bryan

    2008-05-01

    Chisholm, J D Budai and D P Norton Role of charge carriers for ferromagnetism in cobalt-doped rutile TiO2 T Fukumura, H Toyosaki, K Ueno, M Nakano and M Kawasaki Ab-initio study of exchange constants and electronic structure in diluted magnetic group-IV semiconductors Silvia Picozzi and Marjana Ležaić Phase coherent transport in (Ga,Mn)As D Neumaier, K Wagner, U Wurstbauer, M Reinwald, W Wegscheider and D Weiss Hydrogen interstitials-mediated ferromagnetism in MnxGe1-x magnetic semiconductors Xin-Xin Yao, Shi-Shen Yan, Shu-Jun Hu, Xue-Ling Lin, Chong Han, Yan-Xue Chen, Guo-Lei Liu and Liang-Mo Mei Electronic structures of magnetic semiconductors FeCr2Se4 and Fe0.5Cu0.5Cr2Se4 B I Min, Seung Su Baik, H C Choi, S K Kwon and J-S Kang Investigation of pure and Co2+-doped ZnO quantum dot electronic structures using the density functional theory: choosing the right functional Ekaterina Badaeva, Yong Feng, Daniel R Gamelin and Xiaosong Li Magnetic properties of sol-gel-derived doped ZnO as a potential ferromagnetic semiconductor: a synchrotron-based study N R S Farley, K W Edmonds, A A Freeman, G van der Laan, C R Staddon, D H Gregory and B L Gallagher Local electronic structure of Cr in the II-VI diluted ferromagnetic semiconductor Zn1-xCrxTe M Kobayashi, Y Ishida, J I Hwang, G S Song, A Fujimori, C S Yang, L Lee, H-J Lin, D J Huang, C T Chen, Y Takeda, K Terai, S-I Fujimori, T Okane, Y Saitoh, H Yamagami, K Kobayashi, A Tanaka, H Saito and K Ando Lack of ferromagnetism in n-type cobalt-doped ZnO epitaxial thin films T C Kaspar, T Droubay, S M Heald, P Nachimuthu, C M Wang, V Shutthanandan, C A Johnson, D R Gamelin and S A Chambers XMCD studies on Co and Li doped ZnO magnetic semiconductors Thomas Tietze, Milan Gacic, Gisela Schütz, Gerhard Jakob, Sebastian Brück and Eberhard Goering Ferromagnetic semiconductors and the role of disorder B W Wessels An extensive comparison of anisotropies in MBE grown (Ga,Mn)As material C Gould, S Mark, K Pappert, R G Dengel, J Wenisch, R P

  1. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Circulation, Macro- and Microcirculation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    . PATENT DUCTUS ARTERIOSUS, CEREBRAL HAEMODYNAMICS AND INTRAVENTRICULAR HAEMORRHAGE IN PRETERM NEONATES: A CAUSAL PATHWAY STUDY • C. Kotidis, M. Weindling, A. Eleuteri, H. Rabe, M. TurnerABS 16. PRECISION ASSESSMENT OF A NOVEL CEREBRAL TISSUE OXIMETER AND EFFECTS OF FLUCTUATIONS IN SYSTEMIC AND CEREBRAL PHYSIOLOGICAL PARAMETERS • S. Kleiser, D. Ostojic, N. Nasseri, H. Isler, H.U. Bucher, D. Bassler, M. Wolf, F. Scholkmann, T. KarenABS 17. ARGINASE UP-REGULATION AND eNOS UNCOUPLING CONTRIBUTE TO IMPAIRED ENDOTHELIUM-DEPENDENT VASODILATION IN A RAT MODEL OF INTRAUTERINE GROWTH RESTRICTION • I. Grandvuillemin, C. Buffat, F. Boubred, E. Lamy, J. Fromonot, A.C. Peyter, U. Simeoni, C. YzydorczykABS 18. ULTRASONOGRAPHIC MONITORING FOR POST­NATAL ADAPTATION IN PRETERM IN­FANTS • V. Nardi, M.L. Tataranno, S. Di FabioABS 19. RETROSPECTIVE ANALYSIS OF CATHETER RELATED VEIN THROMBOSIS AMONG NEWBORNS IN THE NICU SETTINGS • K. Chojnacka, Z. Krasinski, K. Wróblewska-Seniuk, J. MazelaABS 20. NON-INVASIVE CARDIAC OUTPUT MONITORING BY ELECTRICAL CARDIOMETRY IN HEMODYNAMICALLY STABLE NEONATE INFANTS • J. Shin, E.H. Lee, B.M. ChoiABS 21. MYOCARDIAL DEFORMATION AND ROTATIONAL MECHANICS IN INFANTS WITH DOWN SYNDROME IN THE EARLY NEONATAL PERIOD • C.R. Breatnach, A. Smith, P.T. Levy, N. McCallion, O. Franklin, A. EL-KhuffashABS 22. THE EFFECTS OF DELAYED CORD CLAMPING ON 12-MONTHS BRAIN MYELIN CONTENT: A RANDOMIZED CONTROLLED TRIAL • D. Erickson-Owens, J. Mercer, S. Deoni, A. Parker, J. Collins, J. PadburyABS 23. NEONATOLOGIST-PERFORMED ECHOGRAPHY IN NEONATOLOGY: A TUNISIAN EXPERIENCE • F.Z. Chioukh, K. Ben Ameur, T. Khemis, H. Ajmi, A. Ben Salem, S. Hamdi, H. Ben Hamida, K. MonastiriABS 24. LOW SERUM CORTISOL LEVELS IN ASPHYXIATED INFANTS WITH HEMODYNAMIC INSTABILITY •  K. Kovacs, E. Szakmar, U. Meder, A. Cseko, M. Szabo, A. JermendyABS 25. INFLUENCE OF TYPE OF CONGENITAL HEART DEFECTS ON EPITHELIAL LINING FLUID COMPOSITION IN INFANTS UNDERGOING CARDIAC SURGERY WITH

  2. List of Participants

    Science.gov (United States)

    2007-11-01

    Ceresole Istituto Nazionale di Fisica Nucleare and Università di Torino Kang Sin Choi University of Bonn Michele Cirafici University of Patras Andres Collinucci Katholieke Universiteit Leuven Aldo Cotrone Universitat de Barcelona Ben Craps Vrije Universiteit, Brussel Stefano Cremonesi SISSA, Trieste Gianguido Dall'Agata Padova University Sanjit Das Indian Institute of Technology, Kharagpur Forcella Davide SISSA, Trieste Jose A de Azcarraga Valencia University and Instituto de Fìsica Corpuscular (CSIC-UVEG), Valencia Sophie de BuylInstitut des Hautes Études Scientifiques, Bures-sur-Yvette Jean-Pierre Derendinger Université de Neuchâtel Stephane Detournay Università Degli Studi di Milano Paolo Di Vecchia NORDITA, København Oscar Dias Universitat de Barcelona Vladimir Dobrev Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Sofia Joel Ekstrand Department of Theoretical Physics, Uppsala University Federico Elmetti Università di Milano I Diaconu Eugen University of Craiova Oleg Evnin Vrije Universiteit, Brussel Bo Feng Imperial College, London Livia Ferro Università di Torino Pau Figueras Universitat de Barcelona Raphael Flauger University of Texas at Austin Valentina Forini Università di Perugia Angelos Fotopoulos Università di Torino Denis Frank Université de Neuchâtel Lisa Freyhult Albert-Einstein-Institut, Golm Carlos Fuertes Instituto de Física Teórica, Madrid Matthias Gaberdiel Eidgenössische Technische Hochschule, Zürich Maria Pilar Garcia del Moral Università di Torino Daniel Gerber Instituto de Física Teórica, Madrid Valentina Giangreco Marotta Puletti Uppsala University Joaquim Gomis Universitat de Barcelona Gianluca Grignani Università di Perugia Luca Griguolo Università di Parma Umut Gursoy École Polytechnique, Palaiseau and École Normale Supérieure, Paris Michael Haack Ludwig-Maximilians-Universität, München Troels Harmark Niels Bohr Institute, København Alexander Haupt Imperial College, London Michal

  3. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

    Science.gov (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François

    2011-07-01

    . Rochester, USA)David PUI (U. Minnesota, USA)Eric QUEMENEUR (CEA, FR)Robert SCHALLER (EPFL, CH)Carole SENTEIN (CEA, FR)Ken TAKEDA (U. Tokyo, JP)Louis TREPIED (MINEFE, FR)Jacques VENDEL (IRSN, FR)Olivier WITSCHGER (INRS, FR) List of Participants AGUY SCordouan, FR ALLEMAN LEcole des Mines de Douai, FR ALPER MUniv. California Berkeley, US ALVES O LUNICAMP, BR AMDAOUD MUniv. Joseph Fourier, FR AMODEO TINERIS, FR AMYOTTE PDalhousie Univ., CA ARAKELIAN M CFundacion Argentina de Nanotecnologia, AR ARZAMASTSEVA ETomsk Polytechnic Univ., RU ASCHBERGER KEuropean Commission-JRC, IT ASHTON AJPCS, GB ASIMAKOPOULOU ACERTH/CPER, GR AUBLANT J-MLNE, FR AUDE-GARCIA CCEA, FR AUFFAN MCEREGE, FR AUGER ACEA, FR BAEK MSeoul Woman's Univ., KR BAEZA AUniv. Paris 7 Diderot, FR BAGUET DCEA, FR BARONE FIstituto Superiore di Sanità, IT BAU SINRS, FR BELLEVILLE PCEA, FR BENAZET SSNPE-Matériaux Energétiques, FR BERGER L-MFraunhofer Institute, DE BERGES MDGUV-IFA, DE BERNARD CNIST, US BERNARD DARKEMA, FR BERNE PCEA, FR BERRET J-FUniv. Paris 7 Diderot, FR BIGORGNE ECNRS, FR BILLAT BPMS, FR BLOCH DCEA, FR BOGDANOVIC-GUILLON AFreelance journalist, FR BOIVIN DRESPIREX France, FR BOLAND SUniv. Paris 7 Diderot, FR BOMBARDIER PFAURE QEI, FR BORASCHI DInstitute of Biomedical Technologies, IT BOTTERO J-YCEREGE, FR BRADLEY JLux Research, US BREGOLI LVeneto Nanotech, IT BRIGNON J-MINERIS, FR BROCHOT CIRSN, FR BROUWER DTNO Quality of Life, NL BUDIMAN TTSE-Systems, DE CABOCHE JEcole des Mines de Douai, FR CALLET GCEA, FR CALOGINE DINERIS, FR CAPONIGRO ALoreal, FR CARRIERE MCEA, FR CASSETTE SThales Research & Technology, FR CHARPENTIER DINERIS, FR CHEN C-CTaiwan Univ., TW CHEN LHealth Canada, CA CHEVALLET MCEA, FR CHOI S-JSeoul Woman's Univ., KR CHOU C-CChung Cheng University, TW CHUNG H-ESeoul Woman's Univ., KR CIMPAN MUniv. Bergen, NO CIOBANU NTU Munich, DE CLARK KInstitute for Work and Health, CH CONJEAUD HUniv. Paris 7 Diderot, FR COSTA PEREIRA CNational Health Institute, PT CROOKS MTSI, GB CUPERTINO DC

  4. Selected Abstracts of the 1st Congress of joint European Neonatal Societies (jENS 2015; Budapest (Hungary; September 16-20, 2015; Session “Nutrition and gastroenterology”

    Directory of Open Access Journals (Sweden)

    Various Authors

    2015-09-01

    PROSPECTIVE STUDY • Z. Khan, N. Morris, S. Wallner-Liebmann, N. Haiden, B. UrlesbergerABS 17. AGGRESSIVE VITAMIN D SUPPLEMENTATION IS SAFE AND EFFECTIVE IN PRETERM NEONATES • T. Waterfield, C. Chetcuti-GanadoABS 18. IMPLEMENTING AND SUSTAINING IMPROVED NUTRITIONAL CARE OF PRETERM INFANTS IN NEONATAL INTENSIVE CARE USING A PRACTICE BASED COMPLEX INTERVENTION • M. Johnson, F. Pearson, J. Pond, A. Emm, A. LeafABS 19. PROTEIN ACCRETION AND RESTING ENERGY EXPENDITURE IN VERY LOW BIRTH WEIGHT PRETERM INFANTS ACCORDING TO FEEDING REGIMEN • M.L. Giannì, L. Morlacchi, P. Roggero, E. Battiato, B. Bracco, A. Polimeni, F. MoscaABS 20. PRETERM SINGLE DONOR MILK FROM MOTHERS OF PRETERM INFANTS TO START ENTERAL FEEDINGS IN VERY LOW BIRTH WEIGHT INFANTS • E. Sauerzapf, A. Repa, C. Binder, M. Thanhaeuser, B. Jilma, A. Berger, N. HaidenABS 21. NUTRITIONAL AND CLINICAL OUTCOMES OF THE IMPLEMENTATION OF MULTIDISCIPLINARY NUTRITION SUPPORT TEAM IN A TERTIARY NEONATAL INTENSIVE CARE UNIT • B.K. Lee, E.R. Jeong, I.G. Song, Y.H. Jung, S.H. Shin, E.K. Kim, H.S. Kim, J.H. ChoiABS 22. IS MILKOSCAN™ A RAPID INFRARED ANALYZER, AFTER A SPECIFIC CALIBRATION, ACCURATE AND PRECISE ENOUGH FOR HUMAN MILK FORTIFICATION? • V. de Halleux, R. Buffin, F. Sudsinsky, J.C. Picaud, J. RigoABS 23. EARLY FRESH HUMAN MILK REDUCES THE RISK OF SEPSIS IN VERY LOW BIRTH WEIGHT INFANTS • R. Nieto, A. Dinerstein, C. Solana, D. Ventura, M. Larguía, F. GeneralABS 24. BREAST MILK VERSUS FORMULA FOR THE ENTERAL NUTRITION OF VERY PRETERM INFANTS – OUTCOME AT THE AGE OF ONE AND TWO YEARS • L. Kirchner, N. Klambauer, R. Fuiko, S. BrandstetterABS 25. HYPERGLYCEMIA IN EXTREMELY PRETERM INFANTS LASTS LONGER THAN PREVIOUSLY ACKNOWLEDGED – RESULTS FROM THE EXPRESS STUDY • I.M. Zamir, E. Stoltz Sjöström, F. Ahlsson, M. DomellöfABS 26. BLOOD UREA NITROGEN IN VERY LOW BIRTH WEIGHT INFANTS – A USEFUL MARKER FOR PROTEIN INTAKE? • M. Lindberg, I.M. Zamir, C. Späth, E. Stoltz Sjöström, M. DomellöfABS 27

  5. Evaluation of some software measuring displacements using GPS in real-time

    Science.gov (United States)

    Langbein, John

    2006-01-01

    positions in realtime.Kristine Larson of University of Colorado has modified the original GIPSY to estimate positions kinematically. Again, like TRACK, the positions are estimated off—line. Much of her research is described in Larson et al. (2003), and Choi et al. (2004). For Long Valley, out of the 17 GPS sites, we monitor 5 baselines within the caldera at 5 second intervals relative to the Bald Mountain site at the edge of the caldera using 3DTracker. The baseline measurement using 3DTracker consists of determination of the 3 dimensional positions of the 5 remote points (GPS receivers) relative to a GPS site at Bald. A second, independent system collects and downloads once a day the 30-second data used for the 24-hour solutions for the 12 sites not monitored with 3DTracker. For the sites monitored with 3DTracker, the pseudo—range data are decimated to 30 seconds and converted to a form used for the 24-hour solutions. Both sets of telemetry employ 900 MHz spread spectrum radios which require line of site between all of the links. The telemetry for the 3DTracker sites require a dedicated radios at each end and intermediate repeaters as needed, while the telemetry required for the other sites use a single master radio, repeaters as needed, and a radio at each remote site. (The 5 sites being monitored with 3DTracker require 13 radios.)At Parkfield, RTD is used to measure the position changes all 12 baselines at 1 second intervals relative to a site, Pomm, adjacent to the San Andreas Fault. The complete RTD package (hardware and software) collects all of the data and determines the position of each site relative to Pomm. In addition, the system stores both the 1-second and 30-second pseudo-range data for later downloading which are ultimately used in the 24-hour solutions. To do this, each site has a 2.4 GHz radio and a telemetry buffer. The telemetry buffer holds 24-hours of data (in the event that the telemetry link is broken) and converts the RS232 data stream from the

  6. Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Pulmonology, Neonatal Respiratory Support, Resuscitation"

    Directory of Open Access Journals (Sweden)

    --- Various Authors

    2017-10-01

    , D. McNamara, J.M. AlsweilerABS 96. INHALED NITRIC OXIDE IMPROVES SURVIVAL IN PRETERM INFANTS DIAGNOSED WITH PULMONARY HYPOPLASIA • K. Ellsworth, M. Ellsworth, L. Sangaralingham, R. Clark, G. Asay, C. Colby, W.A. CareyABS 97. NORMALISATION OF PULMONARY GAS EXCHANGE CAPACITY IN VERY PRETERM INFANTS FOLLOWING INITIAL HOSPITAL DISCHARGE DEFINED BY SHIFT OF THE SPO2-PIO2 CURVE • Y.J. Choi, B. Stoecklin, J.J. PillowABS 98. SIMPLIFIED AUSTRALIAN AND NEW ZEALAND NEONATAL NETWORK (ANZNN SHIFT TEST ACCURATELY PREDICTS RIGHTWARD SHIFT OF THE SPO2-PIO2 CURVE IN AN EXTREMELY PRETERM INFANT POPULATION • Y.J. Choi, B. Stoecklin, M.A. Hakeem, P. Woods, J.J. PillowABS 99. CORRELATION BETWEEN BODY TEM­PERA­TURE AND CEREBRAL OXYGENATION IN NEONATES DURING TRANSITION AFTER BIRTH • L.P. Mileder, A. Richter, N. Baik-Schneditz, B. Schwaberger, C. Binder-Heschl, B. Urlesberger, G. PichlerABS 100. A NEONATAL RESUSCITATION ALGORITHM FOR MID-TO-LOW RESOURCE SETTINGS IN MÉDECINS SANS FRONTIÈRES’ PROGRAMS • L. Umphrey, M. Blennow, M. Breindahl, A. Brown, O. Saugstad, M. ThioLluch, D. Trevisanuto, C. RoehrABS 101. NASAL HIGH-FLOW THERAPY AS PRIMARY RESPIRATORY SUPPORT FOR PRETERM INFANTS WITHOUT USE OF NASAL CON­TINUOUS POSITIVE AIRWAYS PRESSURE • S. Zivanovic, A. Scrivens, R. Panza, P. Reynolds, K. Ives, N. Laforgia, C.C. RoehrABS 102. DIURETICS FOR EVOLVING CHRONIC LUNG DISEASE OF PREMATURITY: WHO ARE WE TREATING? • A.K. Linklater, R. Cuzzilla, S.E. JacobsABS 103. NEO (NEONATAL ESOPHAGEAL OBSERVA­TION TUBE – A FEEDING TUBE WITH MONITORING FUNCTION • P. Simmen, B. Jesacher, P.-A. Tran, L. Suter, A. Haeberlin, S.M. Schulzke, T. Niederhauser, K. JostABS 104. CAN TcPCO2 MONITORIZATION IN THE DE­LIVERY ROOM BE HELPFUL FOR DIF­FER­ENTIATING TERM NEWBORNS IN NEED OF HOSPITALIZATION FOR RESPIRATORY MOR­BIDITIES? • I. Mungan Akin, E. Bocu, M. Uygun, S. Sevuk Ozumut, D. Buyukkayhan, S. Arslanoglu, F. OvaliABS 105. HIGH FREQUENCY OSCILLATORY VEN­TI­LATION COMBINED WITH