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Sample records for sampling system validation

  1. Industrial variographic analysis for continuous sampling system validation

    DEFF Research Database (Denmark)

    Engström, Karin; Esbensen, Kim Harry

    2017-01-01

    Karin Engström, LKAB mining, Kiruna, Sweden, continues to present illuminative cases from process industry. Here she reveals more from her ongoing PhD project showing application of variographic characterisation for on-line continuous control of process sampling systems, including the one...

  2. Adaptive importance sampling for probabilistic validation of advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.; Schutter, B. de; Verhaegen, M.

    2006-01-01

    We present an approach for validation of advanced driver assistance systems, based on randomized algorithms. The new method consists of an iterative randomized simulation using adaptive importance sampling. The randomized algorithm is more efficient than conventional simulation techniques. The

  3. Sample size calculation to externally validate scoring systems based on logistic regression models.

    Directory of Open Access Journals (Sweden)

    Antonio Palazón-Bru

    Full Text Available A sample size containing at least 100 events and 100 non-events has been suggested to validate a predictive model, regardless of the model being validated and that certain factors can influence calibration of the predictive model (discrimination, parameterization and incidence. Scoring systems based on binary logistic regression models are a specific type of predictive model.The aim of this study was to develop an algorithm to determine the sample size for validating a scoring system based on a binary logistic regression model and to apply it to a case study.The algorithm was based on bootstrap samples in which the area under the ROC curve, the observed event probabilities through smooth curves, and a measure to determine the lack of calibration (estimated calibration index were calculated. To illustrate its use for interested researchers, the algorithm was applied to a scoring system, based on a binary logistic regression model, to determine mortality in intensive care units.In the case study provided, the algorithm obtained a sample size with 69 events, which is lower than the value suggested in the literature.An algorithm is provided for finding the appropriate sample size to validate scoring systems based on binary logistic regression models. This could be applied to determine the sample size in other similar cases.

  4. Human DNA quantification and sample quality assessment: Developmental validation of the PowerQuant(®) system.

    Science.gov (United States)

    Ewing, Margaret M; Thompson, Jonelle M; McLaren, Robert S; Purpero, Vincent M; Thomas, Kelli J; Dobrowski, Patricia A; DeGroot, Gretchen A; Romsos, Erica L; Storts, Douglas R

    2016-07-01

    Quantification of the total amount of human DNA isolated from a forensic evidence item is crucial for DNA normalization prior to short tandem repeat (STR) DNA analysis and a federal quality assurance standard requirement. Previous commercial quantification methods determine the total human DNA and total human male DNA concentrations, but provide limited information about the condition of the DNA sample. The PowerQuant(®) System includes targets for quantification of total human and total human male DNA as well as targets for evaluating whether the human DNA is degraded and/or PCR inhibitors are present in the sample. A developmental validation of the PowerQuant(®) System was completed, following SWGDAM Validation Guidelines, to evaluate the assay's specificity, sensitivity, precision and accuracy, as well as the ability to detect degraded DNA or PCR inhibitors. In addition to the total human DNA and total human male DNA concentrations in a sample, data from the degradation target and internal PCR control (IPC) provide a forensic DNA analyst meaningful information about the quality of the isolated human DNA and the presence of PCR inhibitors in the sample that can be used to determine the most effective workflow and assist downstream interpretation. Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd.. All rights reserved.

  5. Sampling algorithms for validation of supervised learning models for Ising-like systems

    Science.gov (United States)

    Portman, Nataliya; Tamblyn, Isaac

    2017-12-01

    In this paper, we build and explore supervised learning models of ferromagnetic system behavior, using Monte-Carlo sampling of the spin configuration space generated by the 2D Ising model. Given the enormous size of the space of all possible Ising model realizations, the question arises as to how to choose a reasonable number of samples that will form physically meaningful and non-intersecting training and testing datasets. Here, we propose a sampling technique called ;ID-MH; that uses the Metropolis-Hastings algorithm creating Markov process across energy levels within the predefined configuration subspace. We show that application of this method retains phase transitions in both training and testing datasets and serves the purpose of validation of a machine learning algorithm. For larger lattice dimensions, ID-MH is not feasible as it requires knowledge of the complete configuration space. As such, we develop a new ;block-ID; sampling strategy: it decomposes the given structure into square blocks with lattice dimension N ≤ 5 and uses ID-MH sampling of candidate blocks. Further comparison of the performance of commonly used machine learning methods such as random forests, decision trees, k nearest neighbors and artificial neural networks shows that the PCA-based Decision Tree regressor is the most accurate predictor of magnetizations of the Ising model. For energies, however, the accuracy of prediction is not satisfactory, highlighting the need to consider more algorithmically complex methods (e.g., deep learning).

  6. The use of Geographic Information System (GIS) and non-GIS methods to assess the external validity of samples postcollection.

    Science.gov (United States)

    Richardson, Esther; Good, Margaret; McGrath, Guy; More, Simon J

    2009-09-01

    External validity is fundamental to veterinary diagnostic investigation, reflecting the accuracy with which sample results can be extrapolated to a broader population of interest. Probability sampling methods are routinely used during the collection of samples from populations, specifically to maximize external validity. Nonprobability sampling (e.g., of blood samples collected as part of routine surveillance programs or laboratory submissions) may provide useful data for further posthoc epidemiological analysis, adding value to the collection and submission of samples. As the sample has already been submitted, the analyst or investigator does not have any control over the sampling methodology, and hence external validity as routine probability sampling methods may not have been employed. The current study describes several Geographic Information System (GIS) and non-GIS methods, applied posthoc, to assess the external validity of samples collected using both probability and nonprobability sampling methods. These methods could equally be employed for inspecting other datasets. Mapping was conducted using ArcView 9.1. Based on this posthoc assessment, results from the random field sample could provide an externally valid, albeit relatively imprecise, estimate of national disease prevalence, of disease prevalence in 3 of the 4 provinces (all but Ulster, in the north and northwest, where sample size was small), and in beef and dairy herds. This study provides practical methods for examining the external validity of samples postcollection.

  7. Accounting for sensor calibration, data validation, measurement and sampling uncertainties in monitoring urban drainage systems.

    Science.gov (United States)

    Bertrand-Krajewski, J L; Bardin, J P; Mourad, M; Béranger, Y

    2003-01-01

    Assessing the functioning and the performance of urban drainage systems on both rainfall event and yearly time scales is usually based on online measurements of flow rates and on samples of influent effluent for some rainfall events per year. In order to draw pertinent scientific and operational conclusions from the measurement results, it is absolutely necessary to use appropriate methods and techniques in order to i) calibrate sensors and analytical methods, ii) validate raw data, iii) evaluate measurement uncertainties, iv) evaluate the number of rainfall events to sample per year in order to determine performance indicator with a given uncertainty. Based an previous work, the paper gives a synthetic review of required and techniques, and illustrates their application to storage and settling tanks. Experiments show that, controlled and careful experimental conditions, relative uncertainties are about 20% for flow rates in sewer pipes, 6-10% for volumes, 25-35% for TSS concentrations and loads, and 18-276% for TSS removal rates. In order to evaluate the annual pollutant interception efficiency of storage and settling tanks with a given uncertainty, efforts should first be devoted to decrease the sampling uncertainty by increasing the number of sampled events.

  8. SPENT NUCLEAR FUEL (SNF) PROJECT CANISTER STORAGE BUILDING (CSB) MULTI CANISTER OVERPACK (MCO) SAMPLING SYSTEM VALIDATION (OCRWM)

    International Nuclear Information System (INIS)

    BLACK, D.M.; KLEM, M.J.

    2003-01-01

    Approximately 400 Multi-canister overpacks (MCO) containing spent nuclear fuel are to be interim stored at the Canister Storage Building (CSB). Several MCOs (monitored MCOs) are designated to be gas sampled periodically at the CSB sampling/weld station (Bader 2002a). The monitoring program includes pressure, temperature and gas composition measurements of monitored MCOs during their first two years of interim storage at the CSB. The MCO sample cart (CART-001) is used at the sampling/weld station to measure the monitored MCO gas temperature and pressure, obtain gas samples for laboratory analysis and refill the monitored MCO with high purity helium as needed. The sample cart and support equipment were functionally and operationally tested and validated before sampling of the first monitored MCO (H-036). This report documents the results of validation testing using training MCO (TR-003) at the CSB. Another report (Bader 2002b) documents the sample results from gas sampling of the first monitored MCO (H-036). Validation testing of the MCO gas sampling system showed the equipment and procedure as originally constituted will satisfactorily sample the first monitored MCO. Subsequent system and procedural improvements will provide increased flexibility and reliability for future MCO gas sampling. The physical operation of the sampling equipment during testing provided evidence that theoretical correlation factors for extrapolating MCO gas composition from sample results are unnecessarily conservative. Empirically derived correlation factors showed adequate conservatism and support use of the sample system for ongoing monitored MCO sampling

  9. Validity of the Family Asthma Management System Scale with an Urban African-American Sample

    Science.gov (United States)

    Klinnert, Mary D.; Holsey, Chanda Nicole; McQuaid, Elizabeth L.

    2011-01-01

    Objective To examine the reliability and validity of the Family Asthma Management System Scale for low-income African-American children with poor asthma control and caregivers under stress. The FAMSS assesses eight aspects of asthma management from a family systems perspective. Methods Forty-three children, ages 8–13, and caregivers were interviewed with the FAMSS; caregivers completed measures of primary care quality, family functioning, parenting stress, and psychological distress. Children rated their relatedness with the caregiver, and demonstrated inhaler technique. Medical records were reviewed for dates of outpatient visits for asthma. Results The FAMSS demonstrated good internal consistency. Higher scores were associated with adequate inhaler technique, recent outpatient care, less parenting stress and better family functioning. Higher scores on the Collaborative Relationship with Provider subscale were associated with greater perceived primary care quality. Conclusions The FAMSS demonstrated relevant associations with asthma management criteria and family functioning for a low-income, African-American sample. PMID:19776230

  10. Invention and validation of an automated camera system that uses optical character recognition to identify patient name mislabeled samples.

    Science.gov (United States)

    Hawker, Charles D; McCarthy, William; Cleveland, David; Messinger, Bonnie L

    2014-03-01

    Mislabeled samples are a serious problem in most clinical laboratories. Published error rates range from 0.39/1000 to as high as 1.12%. Standardization of bar codes and label formats has not yet achieved the needed improvement. The mislabel rate in our laboratory, although low compared with published rates, prompted us to seek a solution to achieve zero errors. To reduce or eliminate our mislabeled samples, we invented an automated device using 4 cameras to photograph the outside of a sample tube. The system uses optical character recognition (OCR) to look for discrepancies between the patient name in our laboratory information system (LIS) vs the patient name on the customer label. All discrepancies detected by the system's software then require human inspection. The system was installed on our automated track and validated with production samples. We obtained 1 009 830 images during the validation period, and every image was reviewed. OCR passed approximately 75% of the samples, and no mislabeled samples were passed. The 25% failed by the system included 121 samples actually mislabeled by patient name and 148 samples with spelling discrepancies between the patient name on the customer label and the patient name in our LIS. Only 71 of the 121 mislabeled samples detected by OCR were found through our normal quality assurance process. We have invented an automated camera system that uses OCR technology to identify potential mislabeled samples. We have validated this system using samples transported on our automated track. Full implementation of this technology offers the possibility of zero mislabeled samples in the preanalytic stage.

  11. The validation of a pixe system for trace element analysis of biological samples

    Science.gov (United States)

    Saied, S. O.; Crumpton, D.; Francois, P. E.

    1981-03-01

    A PIXE system has been developed for measuring trace element levels in biological samples and a study made of the precision and accuracy achievable. The calibration of the system has been established using thin targets of known elemental composition and the reproducibility studied using protons of energy 2.5 MeV. Both thick and thin samples prepared from NBS bovine liver have been analysed and the elemental ratios present established for a set of replicate samples. These are compared with the results of other workers. Problems relating to sample preparation are discussed.

  12. Validation of Cs-137 measurement in food samples using gamma spectrometry system

    International Nuclear Information System (INIS)

    Yii Mei Wo; Kamarozaman Ishak

    2005-01-01

    Cs-137 was found to be one of major radionuclide contaminant present in foods consumed by human. In some countries, regulations required consumption foods moving in international trade to be scanned for caesium (Cs-134 and Cs-137) to ensure it does not exceeding the maximum permissible level. This is to ensure that the intake of such foods will not accumulate radionuclide until the significant level inside the human body. Gamma Spectrometry System was used to perform the measurement of caesium isotopes, because it was one of the easiest methods to be performed. This measuring method must be validated for several parameters include specificity, precision (repeatability), bias (accuracy), linearity, range, detection limit, robustness and ruggedness in order to ensure it is fit for the purpose. This paper would summarise how these parameters were fulfilled for this analytical method using several types certified reference materials. The same validated method would be considered workable on Cs-134 as well. (Author)

  13. Evaluation of the Validity of Groundwater Samples Obtained Using the Purge Water Management System at SRS

    International Nuclear Information System (INIS)

    Beardsley, C.C.

    1999-01-01

    As part of the demonstration testing of the Purge Water Management System (PWMS) technology at the Savannah River Site (SRS), four wells were equipped with PWMS units in 1997 and a series of sampling events were conducted at each during 1997-1998. Three of the wells were located in A/M Area while the fourth was located at the Old Radioactive Waste Burial Ground in the General Separations Area.The PWMS is a ''closed-loop'', non-contact, system used to collect and return purge water to the originating aquifer after a sampling event without having significantly altered the water quality. One of the primary concerns as to its applicability at SRS, and elsewhere, is whether the PWMS might resample groundwater that is returned to the aquifer during the previous sampling event. The purpose of the present investigation was to compare groundwater chemical analysis data collected at the four test wells using the PWMS vs. historical data collected using the standard monitoring program methodology to determine if the PWMS provides representative monitoring samples.The analysis of the groundwater chemical concentrations indicates that the PWMS sampling methodology acquired representative groundwater samples at monitoring wells ABP-1A, ABP-4, ARP-3 and BGO-33C. Representative groundwater samples are achieved if the PWMS does not resample groundwater that has been purged and returned during a previous sampling event. Initial screening calculations, conducted prior to the selection of these four wells, indicated that groundwater velocities were high enough under the ambient hydraulic gradients to preclude resampling from occurring at the time intervals that were used at each well. Corroborating evidence included a tracer test that was conducted at BGO-33C, the high degree of similarity between analyte concentrations derived from the PWMS samples and those obtained from historical protocol sampling, as well as the fact that PWMS data extend all previously existing concentration

  14. Adding support to cross-cultural emotional assessment: Validation of the International Affective Picture System in a Chilean sample

    Directory of Open Access Journals (Sweden)

    Rocío Mayol Troncoso

    2011-05-01

    Full Text Available The present study aimed to obtain a valid set of images of the International Affective Picture System (Lang, Bradley, & Cuthbert, 2005 –a widely used instrumentation in emotion research- in a Chilean sample, as well as to compare these results with those obtained from the US study in order to contribute to its cross-cultural validation. A sample of 135 college students assessed 188 pictures according to standard instructions in valence and arousal dimensions. The results showed the expected organization of affectivity, with main variations between sex in valence judgments, and differences between countries in the arousal dimension. It is concluded that the Chilean adaptation of the IAPS is consistent with previous evidence, adding support to it cross-cultural validity.

  15. Cross-cultural validation of the "International affective picture system" (IAPS on a sample from Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Drače Saša

    2013-01-01

    Full Text Available In this study the normative ratings of the International Affective Picture System (IAPS, Center for the Study of Emotion and Attention [CSEA], 1995 were compared with the ratings from a Bosnian sample. Seventy-two psychology undergraduates from the University of Sarajevo (Bosnia and Herzegovina rated valence, dominance and arousal for a stratified sample of 60 pictures that was selected from the IAPS. Reliability coefficients indicate that the self-report ratings are internally consistent. The affective ratings from our sample correlated strongly with the North American ratings at: .95, .81 and .91, respectively for valence, arousal and dominance. Consistent with expectations, mean valence and dominance ratings did not differ significantly between the Bosnian and North American sample. Furthermore, plotting of the Bosnian valence and arousal ratings results in a similar boomerang shaped distribution as the North American affective ratings. Taken together, findings obtained from the Bosnian sample confirm the cross-cultural validity of the IAPS.

  16. Relationship of COP System Interest Inventory Scales to Vocational Preference Inventory (VPI) Scales in a College Sample: Construct Validity of Scales Based on Progressed Occupational Interest.

    Science.gov (United States)

    Omizo, Michael M.; And Others

    1983-01-01

    Construct validity data found some support for the California Occupational Preference System constructs when its results were evaluated on a sample of 213 female undergraduates relative to the Vocational Preference Inventory results. (PN)

  17. Sampling for validation of digital soil maps

    NARCIS (Netherlands)

    Brus, D.J.; Kempen, B.; Heuvelink, G.B.M.

    2011-01-01

    The increase in digital soil mapping around the world means that appropriate and efficient sampling strategies are needed for validation. Data used for calibrating a digital soil mapping model typically are non-random samples. In such a case we recommend collection of additional independent data and

  18. Validation of consistency of Mendelian sampling variance.

    Science.gov (United States)

    Tyrisevä, A-M; Fikse, W F; Mäntysaari, E A; Jakobsen, J; Aamand, G P; Dürr, J; Lidauer, M H

    2018-03-01

    Experiences from international sire evaluation indicate that the multiple-trait across-country evaluation method is sensitive to changes in genetic variance over time. Top bulls from birth year classes with inflated genetic variance will benefit, hampering reliable ranking of bulls. However, none of the methods available today enable countries to validate their national evaluation models for heterogeneity of genetic variance. We describe a new validation method to fill this gap comprising the following steps: estimating within-year genetic variances using Mendelian sampling and its prediction error variance, fitting a weighted linear regression between the estimates and the years under study, identifying possible outliers, and defining a 95% empirical confidence interval for a possible trend in the estimates. We tested the specificity and sensitivity of the proposed validation method with simulated data using a real data structure. Moderate (M) and small (S) size populations were simulated under 3 scenarios: a control with homogeneous variance and 2 scenarios with yearly increases in phenotypic variance of 2 and 10%, respectively. Results showed that the new method was able to estimate genetic variance accurately enough to detect bias in genetic variance. Under the control scenario, the trend in genetic variance was practically zero in setting M. Testing cows with an average birth year class size of more than 43,000 in setting M showed that tolerance values are needed for both the trend and the outlier tests to detect only cases with a practical effect in larger data sets. Regardless of the magnitude (yearly increases in phenotypic variance of 2 or 10%) of the generated trend, it deviated statistically significantly from zero in all data replicates for both cows and bulls in setting M. In setting S with a mean of 27 bulls in a year class, the sampling error and thus the probability of a false-positive result clearly increased. Still, overall estimated genetic

  19. A Method Validation for Determination of Gross Alpha and Gross Beta in Water Sample Using Low Background Gross Alpha/ Beta Counting System

    International Nuclear Information System (INIS)

    Zal Uyun Wan Mahmood; Norfaizal Mohamed; Nita Salina Abu Bakar

    2016-01-01

    Method validation (MV) for the measurement of gross alpha and gross beta activity in water (drinking, mineral and environmental) samples using Low Background Gross Alpha/ Beta Counting System was performed to characterize precision, accuracy and reliable results. The main objective of this assignment is to ensure that both the instrument and method always good performed and resulting accuracy and reliable results. Generally, almost the results of estimated RSD, z-score and U_s_c_o_r_e were reliable which are recorded as ≤30 %, less than 2 and less than 1.5, respectively. Minimum Detected Activity (MDA) was estimated based on the counting time of 100 minutes and present background counting value of gross alpha (0.01 - 0.35 cpm) and gross beta (0.50 - 2.18 cpm). Estimated Detection Limit (DL) was 0.1 Bq/ L for gross alpha and 0.2 Bq/ L for gross beta and expended uncertainty was relatively small of 9.77 % for gross alpha and 10.57 % for gross beta. Align with that, background counting for gross alpha and gross beta was ranged of 0.01 - 0.35 cpm and 0.50 - 2.18 cpm, respectively. While, sample volume was set at minimum of 500 mL and maximum of 2000 mL. These proven the accuracy and precision result that are generated from developed method/ technique is satisfactory and method is recommended to be used. Therefore, it can be concluded that the MV found no doubtful on the ability of the developed method. The test result showed the method is suitable for all types of water samples which are contained several radionuclides and elements as well as any impurities that interfere the measurement analysis of gross alpha and gross beta. (author)

  20. Validation of Autonomous Space Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — System validation addresses the question "Will the system do the right thing?" When system capability includes autonomy, the question becomes more pointed. As NASA...

  1. Optimizing Soil Moisture Sampling Locations for Validation Networks for SMAP

    Science.gov (United States)

    Roshani, E.; Berg, A. A.; Lindsay, J.

    2013-12-01

    Soil Moisture Active Passive satellite (SMAP) is scheduled for launch on Oct 2014. Global efforts are underway for establishment of soil moisture monitoring networks for both the pre- and post-launch validation and calibration of the SMAP products. In 2012 the SMAP Validation Experiment, SMAPVEX12, took place near Carman Manitoba, Canada where nearly 60 fields were sampled continuously over a 6 week period for soil moisture and several other parameters simultaneous to remotely sensed images of the sampling region. The locations of these sampling sites were mainly selected on the basis of accessibility, soil texture, and vegetation cover. Although these criteria are necessary to consider during sampling site selection, they do not guarantee optimal site placement to provide the most efficient representation of the studied area. In this analysis a method for optimization of sampling locations is presented which combines the state-of-art multi-objective optimization engine (non-dominated sorting genetic algorithm, NSGA-II), with the kriging interpolation technique to minimize the number of sampling sites while simultaneously minimizing the differences between the soil moisture map resulted from the kriging interpolation and soil moisture map from radar imaging. The algorithm is implemented in Whitebox Geospatial Analysis Tools, which is a multi-platform open-source GIS. The optimization framework is subject to the following three constraints:. A) sampling sites should be accessible to the crew on the ground, B) the number of sites located in a specific soil texture should be greater than or equal to a minimum value, and finally C) the number of sampling sites with a specific vegetation cover should be greater than or equal to a minimum constraint. The first constraint is implemented into the proposed model to keep the practicality of the approach. The second and third constraints are considered to guarantee that the collected samples from each soil texture categories

  2. Method for validating radiobiological samples using a linear accelerator

    International Nuclear Information System (INIS)

    Brengues, Muriel; Liu, David; Korn, Ronald; Zenhausern, Frederic

    2014-01-01

    There is an immediate need for rapid triage of the population in case of a large scale exposure to ionizing radiation. Knowing the dose absorbed by the body will allow clinicians to administer medical treatment for the best chance of recovery for the victim. In addition, today's radiotherapy treatment could benefit from additional information regarding the patient's sensitivity to radiation before starting the treatment. As of today, there is no system in place to respond to this demand. This paper will describe specific procedures to mimic the effects of human exposure to ionizing radiation creating the tools for optimization of administered radiation dosimetry for radiotherapy and/or to estimate the doses of radiation received accidentally during a radiation event that could pose a danger to the public. In order to obtain irradiated biological samples to study ionizing radiation absorbed by the body, we performed ex-vivo irradiation of human blood samples using the linear accelerator (LINAC). The LINAC was implemented and calibrated for irradiating human whole blood samples. To test the calibration, a 2 Gy test run was successfully performed on a tube filled with water with an accuracy of 3% in dose distribution. To validate our technique the blood samples were ex-vivo irradiated and the results were analyzed using a gene expression assay to follow the effect of the ionizing irradiation by characterizing dose responsive biomarkers from radiobiological assays. The response of 5 genes was monitored resulting in expression increase with the dose of radiation received. The blood samples treated with the LINAC can provide effective irradiated blood samples suitable for molecular profiling to validate radiobiological measurements via the gene-expression based biodosimetry tools. (orig.)

  3. Method for validating radiobiological samples using a linear accelerator.

    Science.gov (United States)

    Brengues, Muriel; Liu, David; Korn, Ronald; Zenhausern, Frederic

    2014-04-29

    There is an immediate need for rapid triage of the population in case of a large scale exposure to ionizing radiation. Knowing the dose absorbed by the body will allow clinicians to administer medical treatment for the best chance of recovery for the victim. In addition, today's radiotherapy treatment could benefit from additional information regarding the patient's sensitivity to radiation before starting the treatment. As of today, there is no system in place to respond to this demand. This paper will describe specific procedures to mimic the effects of human exposure to ionizing radiation creating the tools for optimization of administered radiation dosimetry for radiotherapy and/or to estimate the doses of radiation received accidentally during a radiation event that could pose a danger to the public. In order to obtain irradiated biological samples to study ionizing radiation absorbed by the body, we performed ex-vivo irradiation of human blood samples using the linear accelerator (LINAC). The LINAC was implemented and calibrated for irradiating human whole blood samples. To test the calibration, a 2 Gy test run was successfully performed on a tube filled with water with an accuracy of 3% in dose distribution. To validate our technique the blood samples were ex-vivo irradiated and the results were analyzed using a gene expression assay to follow the effect of the ionizing irradiation by characterizing dose responsive biomarkers from radiobiological assays. The response of 5 genes was monitored resulting in expression increase with the dose of radiation received. The blood samples treated with the LINAC can provide effective irradiated blood samples suitable for molecular profiling to validate radiobiological measurements via the gene-expression based biodosimetry tools.

  4. Magnetic Signature Analysis & Validation System

    National Research Council Canada - National Science Library

    Vliet, Scott

    2001-01-01

    The Magnetic Signature Analysis and Validation (MAGSAV) System is a mobile platform that is used to measure, record, and analyze the perturbations to the earth's ambient magnetic field caused by object such as armored vehicles...

  5. Sampling system and method

    Science.gov (United States)

    Decker, David L.; Lyles, Brad F.; Purcell, Richard G.; Hershey, Ronald Lee

    2013-04-16

    The present disclosure provides an apparatus and method for coupling conduit segments together. A first pump obtains a sample and transmits it through a first conduit to a reservoir accessible by a second pump. The second pump further conducts the sample from the reservoir through a second conduit.

  6. Validation of method in instrumental NAA for food products sample

    International Nuclear Information System (INIS)

    Alfian; Siti Suprapti; Setyo Purwanto

    2010-01-01

    NAA is a method of testing that has not been standardized. To affirm and confirm that this method is valid. it must be done validation of the method with various sample standard reference materials. In this work. the validation is carried for food product samples using NIST SRM 1567a (wheat flour) and NIST SRM 1568a (rice flour). The results show that the validation method for testing nine elements (Al, K, Mg, Mn, Na, Ca, Fe, Se and Zn) in SRM 1567a and eight elements (Al, K, Mg, Mn, Na, Ca, Se and Zn ) in SRM 1568a pass the test of accuracy and precision. It can be conclude that this method has power to give valid result in determination element of the food products samples. (author)

  7. Validated sampling strategy for assessing contaminants in soil stockpiles

    International Nuclear Information System (INIS)

    Lame, Frank; Honders, Ton; Derksen, Giljam; Gadella, Michiel

    2005-01-01

    Dutch legislation on the reuse of soil requires a sampling strategy to determine the degree of contamination. This sampling strategy was developed in three stages. Its main aim is to obtain a single analytical result, representative of the true mean concentration of the soil stockpile. The development process started with an investigation into how sample pre-treatment could be used to obtain representative results from composite samples of heterogeneous soil stockpiles. Combining a large number of random increments allows stockpile heterogeneity to be fully represented in the sample. The resulting pre-treatment method was then combined with a theoretical approach to determine the necessary number of increments per composite sample. At the second stage, the sampling strategy was evaluated using computerised models of contaminant heterogeneity in soil stockpiles. The now theoretically based sampling strategy was implemented by the Netherlands Centre for Soil Treatment in 1995. It was applied to all types of soil stockpiles, ranging from clean to heavily contaminated, over a period of four years. This resulted in a database containing the analytical results of 2570 soil stockpiles. At the final stage these results were used for a thorough validation of the sampling strategy. It was concluded that the model approach has indeed resulted in a sampling strategy that achieves analytical results representative of the mean concentration of soil stockpiles. - A sampling strategy that ensures analytical results representative of the mean concentration in soil stockpiles is presented and validated

  8. The validation of an infrared simulation system

    CSIR Research Space (South Africa)

    De Waal, A

    2013-08-01

    Full Text Available theoretical validation framework. This paper briefly describes the procedure used to validate software models in an infrared system simulation, and provides application examples of this process. The discussion includes practical validation techniques...

  9. Expert system validation in prolog

    Science.gov (United States)

    Stock, Todd; Stachowitz, Rolf; Chang, Chin-Liang; Combs, Jacqueline

    1988-01-01

    An overview of the Expert System Validation Assistant (EVA) is being implemented in Prolog at the Lockheed AI Center. Prolog was chosen to facilitate rapid prototyping of the structure and logic checkers and since February 1987, we have implemented code to check for irrelevance, subsumption, duplication, deadends, unreachability, and cycles. The architecture chosen is extremely flexible and expansible, yet concise and complementary with the normal interactive style of Prolog. The foundation of the system is in the connection graph representation. Rules and facts are modeled as nodes in the graph and arcs indicate common patterns between rules. The basic activity of the validation system is then a traversal of the connection graph, searching for various patterns the system recognizes as erroneous. To aid in specifying these patterns, a metalanguage is developed, providing the user with the basic facilities required to reason about the expert system. Using the metalanguage, the user can, for example, give the Prolog inference engine the goal of finding inconsistent conclusions among the rules, and Prolog will search the graph intantiations which can match the definition of inconsistency. Examples of code for some of the checkers are provided and the algorithms explained. Technical highlights include automatic construction of a connection graph, demonstration of the use of metalanguage, the A* algorithm modified to detect all unique cycles, general-purpose stacks in Prolog, and a general-purpose database browser with pattern completion.

  10. Contingency inferences driven by base rates: Valid by sampling

    Directory of Open Access Journals (Sweden)

    Florian Kutzner

    2011-04-01

    Full Text Available Fiedler et al. (2009, reviewed evidence for the utilization of a contingency inference strategy termed pseudocontingencies (PCs. In PCs, the more frequent levels (and, by implication, the less frequent levels are assumed to be associated. PCs have been obtained using a wide range of task settings and dependent measures. Yet, the readiness with which decision makers rely on PCs is poorly understood. A computer simulation explored two potential sources of subjective validity of PCs. First, PCs are shown to perform above chance level when the task is to infer the sign of moderate to strong population contingencies from a sample of observations. Second, contingency inferences based on PCs and inferences based on cell frequencies are shown to partially agree across samples. Intriguingly, this criterion and convergent validity are by-products of random sampling error, highlighting the inductive nature of contingency inferences.

  11. Design for validation: An approach to systems validation

    Science.gov (United States)

    Carter, William C.; Dunham, Janet R.; Laprie, Jean-Claude; Williams, Thomas; Howden, William; Smith, Brian; Lewis, Carl M. (Editor)

    1989-01-01

    Every complex system built is validated in some manner. Computer validation begins with review of the system design. As systems became too complicated for one person to review, validation began to rely on the application of adhoc methods by many individuals. As the cost of the changes mounted and the expense of failure increased, more organized procedures became essential. Attempts at devising and carrying out those procedures showed that validation is indeed a difficult technical problem. The successful transformation of the validation process into a systematic series of formally sound, integrated steps is necessary if the liability inherent in the future digita-system-based avionic and space systems is to be minimized. A suggested framework and timetable for the transformtion are presented. Basic working definitions of two pivotal ideas (validation and system life-cyle) are provided and show how the two concepts interact. Many examples are given of past and present validation activities by NASA and others. A conceptual framework is presented for the validation process. Finally, important areas are listed for ongoing development of the validation process at NASA Langley Research Center.

  12. Liquid Water from First Principles: Validation of Different Sampling Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Mundy, C J; Kuo, W; Siepmann, J; McGrath, M J; Vondevondele, J; Sprik, M; Hutter, J; Parrinello, M; Mohamed, F; Krack, M; Chen, B; Klein, M

    2004-05-20

    A series of first principles molecular dynamics and Monte Carlo simulations were carried out for liquid water to assess the validity and reproducibility of different sampling approaches. These simulations include Car-Parrinello molecular dynamics simulations using the program CPMD with different values of the fictitious electron mass in the microcanonical and canonical ensembles, Born-Oppenheimer molecular dynamics using the programs CPMD and CP2K in the microcanonical ensemble, and Metropolis Monte Carlo using CP2K in the canonical ensemble. With the exception of one simulation for 128 water molecules, all other simulations were carried out for systems consisting of 64 molecules. It is found that the structural and thermodynamic properties of these simulations are in excellent agreement with each other as long as adiabatic sampling is maintained in the Car-Parrinello molecular dynamics simulations either by choosing a sufficiently small fictitious mass in the microcanonical ensemble or by Nos{acute e}-Hoover thermostats in the canonical ensemble. Using the Becke-Lee-Yang-Parr exchange and correlation energy functionals and norm-conserving Troullier-Martins or Goedecker-Teter-Hutter pseudopotentials, simulations at a fixed density of 1.0 g/cm{sup 3} and a temperature close to 315 K yield a height of the first peak in the oxygen-oxygen radial distribution function of about 3.0, a classical constant-volume heat capacity of about 70 J K{sup -1} mol{sup -1}, and a self-diffusion constant of about 0.1 Angstroms{sup 2}/ps.

  13. A novel high-temperature combustion based system for stable isotope analysis of dissolved organic carbon in aqueous samples. : I development and validation

    NARCIS (Netherlands)

    Federherr, E.; Cerli, C.; Kirkels, F. M. S. A.; Kalbitz, K.; Kupka, H. J.; Dunsbach, R.; Lange, L.; Schmidt, T. C.

    2014-01-01

    RATIONALE: Traditionally, dissolved organic carbon (DOC) stable isotope analysis (SIA) is performed using either offline sample preparation followed by elemental analyzer/isotope ratiomass spectrometry (EA/IRMS) or a wet chemical oxidation (WCO)-based device coupled to an isotope ratio mass

  14. The UK Biobank sample handling and storage validation studies.

    Science.gov (United States)

    Peakman, Tim C; Elliott, Paul

    2008-04-01

    and aims UK Biobank is a large prospective study in the United Kingdom to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. It involves the collection of blood and urine from 500 000 individuals aged between 40 and 69 years. How the samples are collected, processed and stored will have a major impact on the future scientific usefulness of the UK Biobank resource. A series of validation studies was recommended to test the robustness of the draft sample handling and storage protocol. Samples of blood and urine were collected from 40 healthy volunteers and either processed immediately according to the protocol or maintained at specified temperatures (4 degrees C for all tubes with the exception of vacutainers containing acid citrate dextrose that were maintained at 18 degrees C) for 12, 24 or 36 h prior to processing. A further sample was maintained for 24 h at 4 degrees C, processed and the aliquots frozen at -80 degrees C for 20 days and then thawed under controlled conditions. The stability of the samples was compared for the different times in a wide variety of assays. The samples maintained at 4 degrees C were stable for at least 24 h after collection for a wide range of assays. Small but significant changes were observed in metabonomic studies in samples maintained at 4 degrees C for 36 h. There was no degradation of the samples for a range of biochemical assays after short-term freezing and thawing under controlled conditions. Whole blood maintained at 18 degrees C for 24 h in vacutainers containing acid citrate dextrose is suitable for viral immortalization techniques. The validation studies reported in this supplement provide justification for the sample handling and storage procedures adopted in the UK Biobank project.

  15. Validation of single-sample doubly labeled water method

    International Nuclear Information System (INIS)

    Webster, M.D.; Weathers, W.W.

    1989-01-01

    We have experimentally validated a single-sample variant of the doubly labeled water method for measuring metabolic rate and water turnover in a very small passerine bird, the verdin (Auriparus flaviceps). We measured CO 2 production using the Haldane gravimetric technique and compared these values with estimates derived from isotopic data. Doubly labeled water results based on the one-sample calculations differed from Haldane values by less than 0.5% on average (range -8.3 to 11.2%, n = 9). Water flux computed by the single-sample method differed by -1.5% on average from results for the same birds based on the standard, two-sample technique (range -13.7 to 2.0%, n = 9)

  16. SNS Sample Activation Calculator Flux Recommendations and Validation

    Energy Technology Data Exchange (ETDEWEB)

    McClanahan, Tucker C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS); Gallmeier, Franz X. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS); Iverson, Erik B. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS); Lu, Wei [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Spallation Neutron Source (SNS)

    2015-02-01

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL) uses the Sample Activation Calculator (SAC) to calculate the activation of a sample after the sample has been exposed to the neutron beam in one of the SNS beamlines. The SAC webpage takes user inputs (choice of beamline, the mass, composition and area of the sample, irradiation time, decay time, etc.) and calculates the activation for the sample. In recent years, the SAC has been incorporated into the user proposal and sample handling process, and instrument teams and users have noticed discrepancies in the predicted activation of their samples. The Neutronics Analysis Team validated SAC by performing measurements on select beamlines and confirmed the discrepancies seen by the instrument teams and users. The conclusions were that the discrepancies were a result of a combination of faulty neutron flux spectra for the instruments, improper inputs supplied by SAC (1.12), and a mishandling of cross section data in the Sample Activation Program for Easy Use (SAPEU) (1.1.2). This report focuses on the conclusion that the SAPEU (1.1.2) beamline neutron flux spectra have errors and are a significant contributor to the activation discrepancies. The results of the analysis of the SAPEU (1.1.2) flux spectra for all beamlines will be discussed in detail. The recommendations for the implementation of improved neutron flux spectra in SAPEU (1.1.3) are also discussed.

  17. Neutron flux control systems validation

    International Nuclear Information System (INIS)

    Hascik, R.

    2003-01-01

    In nuclear installations main requirement is to obtain corresponding nuclear safety in all operation conditions. From the nuclear safety point of view is commissioning and start-up after reactor refuelling appropriate period for safety systems verification. In this paper, methodology, performance and results of neutron flux measurements systems validation is presented. Standard neutron flux measuring chains incorporated into the reactor protection and control system are used. Standard neutron flux measuring chain contains detector, preamplifier, wiring to data acquisition unit, data acquisition unit, wiring to display at control room and display at control room. During reactor outage only data acquisition unit and wiring and displaying at reactor control room is verified. It is impossible to verify detector, preamplifier and wiring to data acquisition recording unit during reactor refuelling according to low power. Adjustment and accurate functionality of these chains is confirmed by start-up rate (SUR) measurement during start-up tests after refuelling of the reactors. This measurement has direct impact to nuclear safety and increase operational nuclear safety level. Briefly description of each measuring system is given. Results are illustrated on measurements performed at Bohunice NPP during reactor start-up tests. Main failures and their elimination are described (Authors)

  18. Simulation Validation for Societal Systems

    National Research Council Canada - National Science Library

    Yahja, Alex

    2006-01-01

    .... There are however, substantial obstacles to validation. The nature of modeling means that there are implicit model assumptions, a complex model space and interactions, emergent behaviors, and uncodified and inoperable simulation and validation knowledge...

  19. Validation of an off line solid phase extraction liquid chromatography-tandem mass spectrometry method for the determination of systemic insecticide residues in honey and pollen samples collected in apiaries from NW Spain.

    Science.gov (United States)

    García-Chao, María; Agruña, María Jesús; Flores Calvete, Gonzalo; Sakkas, Vasilis; Llompart, María; Dagnac, Thierry

    2010-07-05

    The use of pesticides to protect crops against plagues and insects is one of the most important ways to assure agricultural quality and productivity. However, bad application practices may cause the contamination of different environmental compartments and animal species, as a consequence of migration or accumulation of those compounds. Fipronil, imidacloprid and thiametoxam are systemic or systemic-like insecticides widely used in maize crops. Their heavy action in the nervous system of target insects also means a high toxicity to non-target pollinator insects such as honey bees which can get in touch with them through pollen and nectar during foraging activities. These insecticides have even been suspected to cause a significant decrease of honeybee colonies that has been observed in many countries since the past decade. Since September 1st 2008, the European Commission set new MRLs in food and feed of plant and animal origin. The pesticides included in this study have MRLs in honey and pollen between 10 and 50 ng g(-1). In the present work, an analytical method was developed with the aim of determining residues of fipronil and some of its metabolites (fipronil sulfone, fipronil sulfide, fipronil desulfinyl and fipronil carboxamide), thiamethoxam and imidacloprid in honey and pollen samples. The extraction optimization was performed using a Doehlert experimental design by studying two factors, the mixture and the ratio of solvents used. Prior to the extraction procedure, raw hive samples containing honey, pollen and wax were centrifuged at 4000 rpm. The upper solid material was removed, and 1 g of the lower phase was mixed with 3 mL of the optimized mixture of methanol/water (10/90). The extract was passed through a florisil cartridge and the target compounds were eluted with methanol and analysed by LC-MS/MS in selective reaction monitoring (SRM) mode. The method was validated according to the guidelines included in the SANCO/10684/2009 document and the ISO

  20. Validity of the Malaise Inventory in general population samples.

    Science.gov (United States)

    Rodgers, B; Pickles, A; Power, C; Collishaw, S; Maughan, B

    1999-06-01

    The Malaise Inventory is a commonly used self-completion scale for assessing psychiatric morbidity. There is some evidence that it may represent two separate psychological and somatic subscales rather than a single underlying factor of distress. This paper provides further information on the factor structure of the Inventory and on the reliability and validity of the total scale and two sub-scales. Two general population samples completed the full Inventory: over 11,000 subjects from the National Child Development Study at ages 23 and 33, and 544 mothers of adolescents included in the Isle of Wight epidemiological surveys. The internal consistency of the full 24-item scale and the 15-item psychological subscale were found to be acceptable, but the eight-item somatic sub-scale was less reliable. Factor analysis of all 24 items identified a first main general factor and a second more purely psychological factor. Receiver operating characteristic (ROC) analysis indicated that the validity of the scale held for men and women separately and for different socio-economic groups, by reference to external criteria covering current or recent psychiatric morbidity and service use, and that the psychological sub-scale had no greater validity than the full scale. This study did not support the separate scoring of a somatic sub-scale of the Malaise Inventory. Use of the 15-item psychological sub-scale can be justified on the grounds of reduced time and cost for completion, with little loss of reliability or validity, but this approach would not significantly enhance the properties of the Inventory by comparison with the full 24-item scale. Inclusion of somatic items may be more problematic when the full scale is used to compare particular sub-populations with different propensities for physical morbidity, such as different age groups, and in these circumstances it would be a sensible precaution to utilise the 15-item psychological sub-scale.

  1. Validation of limited sampling models (LSM) for estimating AUC in therapeutic drug monitoring - is a separate validation group required?

    NARCIS (Netherlands)

    Proost, J. H.

    Objective: Limited sampling models (LSM) for estimating AUC in therapeutic drug monitoring are usually validated in a separate group of patients, according to published guidelines. The aim of this study is to evaluate the validation of LSM by comparing independent validation with cross-validation

  2. Validation of KENOREST with LWR-PROTEUS phase II samples

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M.; Kilger, R.; Pautz, A.; Zwermann, W. [GRS, Garching (Germany); Grimm, P.; Vasiliev, A.; Ferroukhi, H. [Paul Scherrer Institut, Villigen (Switzerland)

    2012-11-01

    In order to broaden the validation basis of the reactivity and nuclide inventory code KENOREST two samples of the LWR-PROTEUS phase II program have been calculated and compared to the experimental results. In general most nuclides are reproduced very well and agree within about ten percent with the experiment. Some already known problems, the overprediction of metallic fission products and the underprediction of the higher curium isotopes, have been confirmed. One of the largest uncertainties in the calculation was the burnup of the samples due to differences between a core simulation of the fuel vendor and the burnup determined from the measured values of the burnup indicator Nd-148. Two different models taking into account the environment for a peripheral fuel rod have been studied. The more detailed model included the three direct neighbor fuel assemblies depleted along with the fuel rod of interest. The influence on the results has been found to be very small. Compared to the uncertainties from the burnup, this effect can be considered negligible. The reason for the low influence was basically that the spectrum did not get considerably harder with increasing burnup beyond about 20GWd/tHM. Since the sample reached burnups far beyond that value, an effect could not be seen. In the near future an update of the used libraries is planned and it will be very interesting to study the effect on the results, especially for Curium. (orig.)

  3. Validity and validation of expert (Q)SAR systems.

    Science.gov (United States)

    Hulzebos, E; Sijm, D; Traas, T; Posthumus, R; Maslankiewicz, L

    2005-08-01

    At a recent workshop in Setubal (Portugal) principles were drafted to assess the suitability of (quantitative) structure-activity relationships ((Q)SARs) for assessing the hazards and risks of chemicals. In the present study we applied some of the Setubal principles to test the validity of three (Q)SAR expert systems and validate the results. These principles include a mechanistic basis, the availability of a training set and validation. ECOSAR, BIOWIN and DEREK for Windows have a mechanistic or empirical basis. ECOSAR has a training set for each QSAR. For half of the structural fragments the number of chemicals in the training set is >4. Based on structural fragments and log Kow, ECOSAR uses linear regression to predict ecotoxicity. Validating ECOSAR for three 'valid' classes results in predictivity of > or = 64%. BIOWIN uses (non-)linear regressions to predict the probability of biodegradability based on fragments and molecular weight. It has a large training set and predicts non-ready biodegradability well. DEREK for Windows predictions are supported by a mechanistic rationale and literature references. The structural alerts in this program have been developed with a training set of positive and negative toxicity data. However, to support the prediction only a limited number of chemicals in the training set is presented to the user. DEREK for Windows predicts effects by 'if-then' reasoning. The program predicts best for mutagenicity and carcinogenicity. Each structural fragment in ECOSAR and DEREK for Windows needs to be evaluated and validated separately.

  4. Verification and Validation in Systems Engineering

    CERN Document Server

    Debbabi, Mourad; Jarraya, Yosr; Soeanu, Andrei; Alawneh, Luay

    2010-01-01

    "Verification and validation" represents an important process used for the quality assessment of engineered systems and their compliance with the requirements established at the beginning of or during the development cycle. Debbabi and his coauthors investigate methodologies and techniques that can be employed for the automatic verification and validation of systems engineering design models expressed in standardized modeling languages. Their presentation includes a bird's eye view of the most prominent modeling languages for software and systems engineering, namely the Unified Model

  5. Validation of the Novaco Anger Scale-Provocation Inventory (Danish) With Nonclinical, Clinical, and Offender Samples

    DEFF Research Database (Denmark)

    Moeller, Stine Bjerrum; Novaco, Raymond; Heinola-Nielsen, Vivian

    2015-01-01

    Anger has high prevalence in clinical and forensic settings, and it is associated with aggressive behavior and ward atmosphere on psychiatric units. Dysregulated anger is a clinical problem in Danish mental health care systems, but no anger assessment instruments have been validated in Danish...... investigated with samples of 477 nonclinical, 250 clinical, 167 male prisoner, and 64 male forensic participants. Anger prevalence and its relationship with other anger measures, anxiety/depression, and aggression were examined. NAS-PI was found to have high reliability, concurrent validity, and discriminant...

  6. Simulation Validation for Societal Systems

    Science.gov (United States)

    2006-09-01

    system. Rather than assuming the existence of an expert experienced in diagnosing a problem, model-based approaches assume the existence of a system...system behavior is required, the method is capable of diagnosing faults that have never occurred before. 44 3.1.5 Causal Reasoning When...BioWar has hundreds of parameters. The resulting parameter space is gigantic . Suppose that the Response Surface Methodology or RSM (Myers and Montgomery

  7. Validation Of Critical Knowledge-Based Systems

    Science.gov (United States)

    Duke, Eugene L.

    1992-01-01

    Report discusses approach to verification and validation of knowledge-based systems. Also known as "expert systems". Concerned mainly with development of methodologies for verification of knowledge-based systems critical to flight-research systems; e.g., fault-tolerant control systems for advanced aircraft. Subject matter also has relevance to knowledge-based systems controlling medical life-support equipment or commuter railroad systems.

  8. Validation of Metrics for Collaborative Systems

    Directory of Open Access Journals (Sweden)

    Ion IVAN

    2008-01-01

    Full Text Available This paper describe the new concepts of collaborative systems metrics validation. The paper define the quality characteristics of collaborative systems. There are proposed a metric to estimate the quality level of collaborative systems. There are performed measurements of collaborative systems quality using a specially designed software.

  9. Validation of Metrics for Collaborative Systems

    OpenAIRE

    Ion IVAN; Cristian CIUREA

    2008-01-01

    This paper describe the new concepts of collaborative systems metrics validation. The paper define the quality characteristics of collaborative systems. There are proposed a metric to estimate the quality level of collaborative systems. There are performed measurements of collaborative systems quality using a specially designed software.

  10. Wideband feedback system prototype validation

    CERN Document Server

    Li, K; Bjorsvik, E; Fox, J; Hofle, W; Kotzian, G; Rivetta, C; Salvant, B; Turgut, O

    2017-01-01

    A wideband feedback demonstrator system has been de-veloped in collaboration with US-LARP under the joint lead-ership of CERN and SLAC. The system includes widebandkicker structures and amplifiers along with a fast digital re-configurable system up to 4 GS/s for single bunch and multibunch control. Most of the components have been installedin recent years and have been put into operation to test bothintra-bunch damping and individual bunch control in a multibunch train. In this note we report on the MD program,procedure and key findings that were made with this systemin the past year.

  11. Validity of Sensory Systems as Distinct Constructs

    OpenAIRE

    Su, Chia-Ting; Parham, L. Diane

    2014-01-01

    Confirmatory factor analysis testing whether sensory questionnaire items represented distinct sensory system constructs found, using data from two age groups, that such constructs can be measured validly using questionnaire data.

  12. Data validation report for the 100-FR-3 Operable Unit, third round groundwater samples

    International Nuclear Information System (INIS)

    Ayres, J.M.

    1994-01-01

    Westinghouse-Hanford has requested that a minimum of 20% of the total number of Sample Delivery Groups be validated for the 100-FR-3 operable Unit Third Round Groundwater sampling investigation. Therefore, the data from the chemical analysis of 51 samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. The report is broken down into sections for each chemical analysis and radiochemical analysis type. Each section addresses the data package completeness, holding time adherence, instrument calibration and tuning acceptability, blank results, accuracy, precision, system performance, as well as the compound identification and quantitation. In addition, each section has an overall assessment and summary for the data packages reviewed for the particular chemical/radiochemical analyses. Detailed backup information is provided to the reader by SDG No. and sample number. For each data package, a matrix of chemical analyses per sample number is presented, as well as data qualification summaries

  13. Core sampling system spare parts assessment

    International Nuclear Information System (INIS)

    Walter, E.J.

    1995-01-01

    Soon, there will be 4 independent core sampling systems obtaining samples from the underground tanks. It is desirable that these systems be available for sampling during the next 2 years. This assessment was prepared to evaluate the adequacy of the spare parts identified for the core sampling system and to provide recommendations that may remediate overages or inadequacies of spare parts

  14. Robotic system for process sampling

    International Nuclear Information System (INIS)

    Dyches, G.M.

    1985-01-01

    A three-axis cartesian geometry robot for process sampling was developed at the Savannah River Laboratory (SRL) and implemented in one of the site radioisotope separations facilities. Use of the robot reduces personnel radiation exposure and contamination potential by routinely handling sample containers under operator control in a low-level radiation area. This robot represents the initial phase of a longer term development program to use robotics for further sample automation. Preliminary design of a second generation robot with additional capabilities is also described. 8 figs

  15. Spatiotemporally Representative and Cost-Efficient Sampling Design for Validation Activities in Wanglang Experimental Site

    Directory of Open Access Journals (Sweden)

    Gaofei Yin

    2017-11-01

    Full Text Available Spatiotemporally representative Elementary Sampling Units (ESUs are required for capturing the temporal variations in surface spatial heterogeneity through field measurements. Since inaccessibility often coexists with heterogeneity, a cost-efficient sampling design is mandatory. We proposed a sampling strategy to generate spatiotemporally representative and cost-efficient ESUs based on the conditioned Latin hypercube sampling scheme. The proposed strategy was constrained by multi-temporal Normalized Difference Vegetation Index (NDVI imagery, and the ESUs were limited within a sampling feasible region established based on accessibility criteria. A novel criterion based on the Overlapping Area (OA between the NDVI frequency distribution histogram from the sampled ESUs and that from the entire study area was used to assess the sampling efficiency. A case study in Wanglang National Nature Reserve in China showed that the proposed strategy improves the spatiotemporally representativeness of sampling (mean annual OA = 74.7% compared to the single-temporally constrained (OA = 68.7% and the random sampling (OA = 63.1% strategies. The introduction of the feasible region constraint significantly reduces in-situ labour-intensive characterization necessities at expenses of about 9% loss in the spatiotemporal representativeness of the sampling. Our study will support the validation activities in Wanglang experimental site providing a benchmark for locating the nodes of automatic observation systems (e.g., LAINet which need a spatially distributed and temporally fixed sampling design.

  16. Validation of EIA sampling methods - bacterial and biochemical analysis

    Digital Repository Service at National Institute of Oceanography (India)

    Sheelu, G.; LokaBharathi, P.A.; Nair, S.; Raghukumar, C.; Mohandass, C.

    to temporal factors. Paired T-test between pre- and post-disturbance samples suggested that the above methods of sampling and variables like TC, protein and TOC could be used for monitoring disturbance....

  17. Validating Teacher Commitment Scale Using a Malaysian Sample

    Directory of Open Access Journals (Sweden)

    Lei Mee Thien

    2014-05-01

    Full Text Available This study attempts to validate an integrative Teacher Commitment scale using rigorous scale validation procedures. An adapted questionnaire with 17 items was administered to 600 primary school teachers in Penang, Malaysia. Data were analyzed using exploratory factor analysis (EFA and confirmatory factor analysis (CFA with SPSS 19.0 and AMOS 19.0, respectively. The results support Teacher Commitment as a multidimensional construct with its four underlying dimensions: Commitment to Student, Commitment to Teaching, Commitment to School, and Commitment to Profession. A validated Teacher Commitment scale with 13 items measured can be proposed to be used as an evaluative tool to assess the level to which teachers are committed to their students’ learning, teaching, school, and profession. The Teacher Commitment scale would also facilitate the identifications of factors that influence teachers’ quality of work life and school effectiveness. The practical implications, school cultural influence, and methodological limitations are discussed.

  18. Data validation report for the 100-HR-3 Operable Unit, fifth round groundwater samples

    International Nuclear Information System (INIS)

    Vukelich, S.E.

    1994-01-01

    The data from the chemical analysis of 68 samples from the 100-HR-3 Operable Unit Third Quarter 1993 Groundwater Sampling Investigation and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at the site. Sample analysis included inorganics and general chemical parameters. Fifty three samples were validated for radiochemical parameters

  19. Data validation report for the 100-D Ponds Operable Unit: 100-D ponds sampling

    International Nuclear Information System (INIS)

    Stankovich, M.T.

    1994-01-01

    Westinghouse-Hanford has requested that 100 percent of the Sample Delivery Groups be validated for the 100-D Ponds Operable Unit Sampling Investigation. Therefore the data from the chemical analysis of all 30 samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site

  20. Data validation summary report for the 100-BC-5 Operable Unit Round 8 Groundwater Sampling

    International Nuclear Information System (INIS)

    Kearney, A.T.

    1996-03-01

    The information provided in this validation summary report includes data from the chemical analyses of samples from the 100-BC-5 Operable Unit Round 8 Groundwater Sampling Investigation. All of the data from this sampling event and their related quality assurance samples were reviewed and validated to verify that the reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. Sample analyses included metals, general chemistry and radiochemistry

  1. Method validation in plasma source optical emission spectroscopy (ICP-OES) - From samples to results

    International Nuclear Information System (INIS)

    Pilon, Fabien; Vielle, Karine; Birolleau, Jean-Claude; Vigneau, Olivier; Labet, Alexandre; Arnal, Nadege; Adam, Christelle; Camilleri, Virginie; Amiel, Jeanine; Granier, Guy; Faure, Joel; Arnaud, Regine; Beres, Andre; Blanchard, Jean-Marc; Boyer-Deslys, Valerie; Broudic, Veronique; Marques, Caroline; Augeray, Celine; Bellefleur, Alexandre; Bienvenu, Philippe; Delteil, Nicole; Boulet, Beatrice; Bourgarit, David; Brennetot, Rene; Fichet, Pascal; Celier, Magali; Chevillotte, Rene; Klelifa, Aline; Fuchs, Gilbert; Le Coq, Gilles; Mermet, Jean-Michel

    2017-01-01

    Even though ICP-OES (Inductively Coupled Plasma - Optical Emission Spectroscopy) is now a routine analysis technique, requirements for measuring processes impose a complete control and mastering of the operating process and of the associated quality management system. The aim of this (collective) book is to guide the analyst during all the measurement validation procedure and to help him to guarantee the mastering of its different steps: administrative and physical management of samples in the laboratory, preparation and treatment of the samples before measuring, qualification and monitoring of the apparatus, instrument setting and calibration strategy, exploitation of results in terms of accuracy, reliability, data covariance (with the practical determination of the accuracy profile). The most recent terminology is used in the book, and numerous examples and illustrations are given in order to a better understanding and to help the elaboration of method validation documents

  2. Water sample-collection and distribution system

    Science.gov (United States)

    Brooks, R. R.

    1978-01-01

    Collection and distribution system samples water from six designated stations, filtered if desired, and delivers it to various analytical sensors. System may be controlled by Water Monitoring Data Acquisition System or operated manually.

  3. Data Validation Package - July 2016 Groundwater Sampling at the Gunnison, Colorado, Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    Linard, Joshua [USDOE Office of Legacy Management, Washington, DC (United States); Campbell, Sam [Navarro Research and Engineering, Inc., Las Vegas, NV (United States)

    2016-10-25

    Groundwater sampling at the Gunnison, Colorado, Disposal Site is conducted every 5 years to monitor disposal cell performance. During this event, samples were collected from eight monitoring wells as specified in the 1997 Long-Term Surveillance Plan for the Gunnison, Colorado, Disposal Site. Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for US Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated, http://energy.gov/lm/downloads/sampling-and­ analysis-plan-us-department-energy-office-legacy-management-sites). Planned monitoring locations are shown in Attachment 1, Sampling and Analysis Work Order. A duplicate sample was collected from location 0723. Water levels were measured at all monitoring wells that were sampled and seven additional wells. The analytical data and associated qualifiers can be viewed in environmental database reports and are also available for viewing with dynamic mapping via the GEMS (Geospatial Environmental Mapping System) website at http://gems.lm.doe.gov/#. No issues were identified during the data validation process that require additional action or follow-up.

  4. A Consistent System for Coding Laboratory Samples

    Science.gov (United States)

    Sih, John C.

    1996-07-01

    A formal laboratory coding system is presented to keep track of laboratory samples. Preliminary useful information regarding the sample (origin and history) is gained without consulting a research notebook. Since this system uses and retains the same research notebook page number for each new experiment (reaction), finding and distinguishing products (samples) of the same or different reactions becomes an easy task. Using this system multiple products generated from a single reaction can be identified and classified in a uniform fashion. Samples can be stored and filed according to stage and degree of purification, e.g. crude reaction mixtures, recrystallized samples, chromatographed or distilled products.

  5. Controls to validate plasma samples for cell free DNA quantification

    DEFF Research Database (Denmark)

    Pallisgaard, Niels; Spindler, Karen-Lise Garm; Andersen, Rikke Fredslund

    2015-01-01

    , are diverging due to methodological differences with lack of standardisation and definition of sensitivity. The new biological information has not yet come into routine use. The present study presents external standardisation by spiking with non-human DNA fragments to control for loss of DNA during sample...... preparation and measurement. It also suggests a method to control for admixture of DNA from normal lymphocytes by utilizing the unique immunoglobulin gene rearrangement in the B-cells. The results show that this approach improves the quality of the analysis and lowers the risk of falsely increased values...

  6. Model validation: a systemic and systematic approach

    International Nuclear Information System (INIS)

    Sheng, G.; Elzas, M.S.; Cronhjort, B.T.

    1993-01-01

    The term 'validation' is used ubiquitously in association with the modelling activities of numerous disciplines including social, political natural, physical sciences, and engineering. There is however, a wide range of definitions which give rise to very different interpretations of what activities the process involves. Analyses of results from the present large international effort in modelling radioactive waste disposal systems illustrate the urgent need to develop a common approach to model validation. Some possible explanations are offered to account for the present state of affairs. The methodology developed treats model validation and code verification in a systematic fashion. In fact, this approach may be regarded as a comprehensive framework to assess the adequacy of any simulation study. (author)

  7. Structural system identification: Structural dynamics model validation

    Energy Technology Data Exchange (ETDEWEB)

    Red-Horse, J.R.

    1997-04-01

    Structural system identification is concerned with the development of systematic procedures and tools for developing predictive analytical models based on a physical structure`s dynamic response characteristics. It is a multidisciplinary process that involves the ability (1) to define high fidelity physics-based analysis models, (2) to acquire accurate test-derived information for physical specimens using diagnostic experiments, (3) to validate the numerical simulation model by reconciling differences that inevitably exist between the analysis model and the experimental data, and (4) to quantify uncertainties in the final system models and subsequent numerical simulations. The goal of this project was to develop structural system identification techniques and software suitable for both research and production applications in code and model validation.

  8. Data validation report for the 100-HR-3 Operable Unit first quarter 1994 groundwater sampling data

    Energy Technology Data Exchange (ETDEWEB)

    Biggerstaff, R.L.

    1994-06-24

    Westinghouse-Hanford has requested that a minimum of 20% of the total number of Sample Delivery Groups be validated for the 100-HR-3 Operable Unit First Quarter 1994 Groundwater Sampling Investigation. Therefore, the data from the chemical analysis of twenty-four samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. The samples were analyzed by Thermo-Analytic Laboratories (TMA) and Roy F. Weston Laboratories (WESTON) using US Environmental Protection Agency (EPA) CLP protocols. Sample analyses included: inorganics; and general chemical parameters. Forty-two samples were validated for radiochemical parameters by TMA and Teledyne.

  9. Data validation report for the 100-HR-3 Operable Unit first quarter 1994 groundwater sampling data

    International Nuclear Information System (INIS)

    Biggerstaff, R.L.

    1994-01-01

    Westinghouse-Hanford has requested that a minimum of 20% of the total number of Sample Delivery Groups be validated for the 100-HR-3 Operable Unit First Quarter 1994 Groundwater Sampling Investigation. Therefore, the data from the chemical analysis of twenty-four samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. The samples were analyzed by Thermo-Analytic Laboratories (TMA) and Roy F. Weston Laboratories (WESTON) using US Environmental Protection Agency (EPA) CLP protocols. Sample analyses included: inorganics; and general chemical parameters. Forty-two samples were validated for radiochemical parameters by TMA and Teledyne

  10. Validation of three compulsive buying scales on an Italian sample.

    Science.gov (United States)

    Tommasi, Marco; Busonera, Alessandra

    2012-12-01

    Compulsive shopping is an impulse control disorder that produces psychological distress. Appropriate measurement scales of compulsive buying are important to identify compulsive buyers. Three compulsive buying scales (Faber and O'Guinn scale, Edwards scale, Yale and Brown scale) were tested in an Italian sample composed of 438 participants randomly selected from the general population. Self-report questionnaires measured psychiatric dysfunctions and personality traits. The data confirmed that high anxiety, obsessive-compulsive dysfunctions, depression, psychoticism, and low self-esteem were associated with inappropriate shopping. The Faber and O'Guinn scale and Edwards Scale are appropriate for surveys, while the Yale and Brown scale are more appropriate for clinical diagnosis of psychological dependences.

  11. Planetary Sample Caching System Design Options

    Science.gov (United States)

    Collins, Curtis; Younse, Paulo; Backes, Paul

    2009-01-01

    Potential Mars Sample Return missions would aspire to collect small core and regolith samples using a rover with a sample acquisition tool and sample caching system. Samples would need to be stored in individual sealed tubes in a canister that could be transfered to a Mars ascent vehicle and returned to Earth. A sample handling, encapsulation and containerization system (SHEC) has been developed as part of an integrated system for acquiring and storing core samples for application to future potential MSR and other potential sample return missions. Requirements and design options for the SHEC system were studied and a recommended design concept developed. Two families of solutions were explored: 1)transfer of a raw sample from the tool to the SHEC subsystem and 2)transfer of a tube containing the sample to the SHEC subsystem. The recommended design utilizes sample tool bit change out as the mechanism for transferring tubes to and samples in tubes from the tool. The SHEC subsystem design, called the Bit Changeout Caching(BiCC) design, is intended for operations on a MER class rover.

  12. Validated methodology for quantifying infestation levels of dreissenid mussels in environmental DNA (eDNA) samples.

    Science.gov (United States)

    Peñarrubia, Luis; Alcaraz, Carles; Vaate, Abraham Bij de; Sanz, Nuria; Pla, Carles; Vidal, Oriol; Viñas, Jordi

    2016-12-14

    The zebra mussel (Dreissena polymorpha Pallas, 1771) and the quagga mussel (D. rostriformis Deshayes, 1838) are successful invasive bivalves with substantial ecological and economic impacts in freshwater systems once they become established. Since their eradication is extremely difficult, their detection at an early stage is crucial to prevent spread. In this study, we optimized and validated a qPCR detection method based on the histone H2B gene to quantify combined infestation levels of zebra and quagga mussels in environmental DNA samples. Our results show specific dreissenid DNA present in filtered water samples for which microscopic diagnostic identification for larvae failed. Monitoring a large number of locations for invasive dreissenid species based on a highly specific environmental DNA qPCR assay may prove to be an essential tool for management and control plans focused on prevention of establishment of dreissenid mussels in new locations.

  13. The Depressive Experiences Questionnaire: validity and psychological correlates in a clinical sample.

    Science.gov (United States)

    Riley, W T; McCranie, E W

    1990-01-01

    This study sought to compare the original and revised scoring systems of the Depressive Experiences Questionnaire (DEQ) and to assess the construct validity of the Dependent and Self-Critical subscales of the DEQ in a clinically depressed sample. Subjects were 103 depressed inpatients who completed the DEQ, the Beck Depression Inventory (BDI), the Hopelessness Scale, the Automatic Thoughts Questionnaire (ATQ), the Rathus Assertiveness Schedule (RAS), and the Minnesota Multiphasic Personality Inventory (MMPI). The original and revised scoring systems of the DEQ evidenced good concurrent validity for each factor scale, but the revised system did not sufficiently discriminate dependent and self-critical dimensions. Using the original scoring system, self-criticism was significantly and positively related to severity of depression, whereas dependency was not, particularly for males. Factor analysis of the DEQ scales and the other scales used in this study supported the dependent and self-critical dimensions. For men, the correlation of the DEQ with the MMPI scales indicated that self-criticism was associated with psychotic symptoms, hostility/conflict, and a distress/exaggerated response set, whereas dependency did not correlate significantly with any MMPI scales. Females, however, did not exhibit a differential pattern of correlations between either the Dependency or the Self-Criticism scales and the MMPI. These findings suggest possible gender differences in the clinical characteristics of male and female dependent and self-critical depressive subtypes.

  14. Assessing the Validity of Single-item Life Satisfaction Measures: Results from Three Large Samples

    Science.gov (United States)

    Cheung, Felix; Lucas, Richard E.

    2014-01-01

    Purpose The present paper assessed the validity of single-item life satisfaction measures by comparing single-item measures to the Satisfaction with Life Scale (SWLS) - a more psychometrically established measure. Methods Two large samples from Washington (N=13,064) and Oregon (N=2,277) recruited by the Behavioral Risk Factor Surveillance System (BRFSS) and a representative German sample (N=1,312) recruited by the Germany Socio-Economic Panel (GSOEP) were included in the present analyses. Single-item life satisfaction measures and the SWLS were correlated with theoretically relevant variables, such as demographics, subjective health, domain satisfaction, and affect. The correlations between the two life satisfaction measures and these variables were examined to assess the construct validity of single-item life satisfaction measures. Results Consistent across three samples, single-item life satisfaction measures demonstrated substantial degree of criterion validity with the SWLS (zero-order r = 0.62 – 0.64; disattenuated r = 0.78 – 0.80). Patterns of statistical significance for correlations with theoretically relevant variables were the same across single-item measures and the SWLS. Single-item measures did not produce systematically different correlations compared to the SWLS (average difference = 0.001 – 0.005). The average absolute difference in the magnitudes of the correlations produced by single-item measures and the SWLS were very small (average absolute difference = 0.015 −0.042). Conclusions Single-item life satisfaction measures performed very similarly compared to the multiple-item SWLS. Social scientists would get virtually identical answer to substantive questions regardless of which measure they use. PMID:24890827

  15. Assessing the validity of single-item life satisfaction measures: results from three large samples.

    Science.gov (United States)

    Cheung, Felix; Lucas, Richard E

    2014-12-01

    The present paper assessed the validity of single-item life satisfaction measures by comparing single-item measures to the Satisfaction with Life Scale (SWLS)-a more psychometrically established measure. Two large samples from Washington (N = 13,064) and Oregon (N = 2,277) recruited by the Behavioral Risk Factor Surveillance System and a representative German sample (N = 1,312) recruited by the Germany Socio-Economic Panel were included in the present analyses. Single-item life satisfaction measures and the SWLS were correlated with theoretically relevant variables, such as demographics, subjective health, domain satisfaction, and affect. The correlations between the two life satisfaction measures and these variables were examined to assess the construct validity of single-item life satisfaction measures. Consistent across three samples, single-item life satisfaction measures demonstrated substantial degree of criterion validity with the SWLS (zero-order r = 0.62-0.64; disattenuated r = 0.78-0.80). Patterns of statistical significance for correlations with theoretically relevant variables were the same across single-item measures and the SWLS. Single-item measures did not produce systematically different correlations compared to the SWLS (average difference = 0.001-0.005). The average absolute difference in the magnitudes of the correlations produced by single-item measures and the SWLS was very small (average absolute difference = 0.015-0.042). Single-item life satisfaction measures performed very similarly compared to the multiple-item SWLS. Social scientists would get virtually identical answer to substantive questions regardless of which measure they use.

  16. Instrument validation system of general application

    International Nuclear Information System (INIS)

    Filshtein, E.L.

    1990-01-01

    This paper describes the Instrument Validation System (IVS) as a software system which has the capability of evaluating the performance of a set of functionally related instrument channels to identify failed instruments and to quantify instrument drift. Under funding from Combustion Engineering (C-E), the IVS has been developed to the extent that a computer program exists whose use has been demonstrated. The initial development work shows promise for success and for wide application, not only to power plants, but also to industrial manufacturing and process control. Applications in the aerospace and military sector are also likely

  17. Impacts of Sample Design for Validation Data on the Accuracy of Feedforward Neural Network Classification

    Directory of Open Access Journals (Sweden)

    Giles M. Foody

    2017-08-01

    Full Text Available Validation data are often used to evaluate the performance of a trained neural network and used in the selection of a network deemed optimal for the task at-hand. Optimality is commonly assessed with a measure, such as overall classification accuracy. The latter is often calculated directly from a confusion matrix showing the counts of cases in the validation set with particular labelling properties. The sample design used to form the validation set can, however, influence the estimated magnitude of the accuracy. Commonly, the validation set is formed with a stratified sample to give balanced classes, but also via random sampling, which reflects class abundance. It is suggested that if the ultimate aim is to accurately classify a dataset in which the classes do vary in abundance, a validation set formed via random, rather than stratified, sampling is preferred. This is illustrated with the classification of simulated and remotely-sensed datasets. With both datasets, statistically significant differences in the accuracy with which the data could be classified arose from the use of validation sets formed via random and stratified sampling (z = 2.7 and 1.9 for the simulated and real datasets respectively, for both p < 0.05%. The accuracy of the classifications that used a stratified sample in validation were smaller, a result of cases of an abundant class being commissioned into a rarer class. Simple means to address the issue are suggested.

  18. System for Earth Sample Registration SESAR: Services for IGSN Registration and Sample Metadata Management

    Science.gov (United States)

    Chan, S.; Lehnert, K. A.; Coleman, R. J.

    2011-12-01

    SESAR, the System for Earth Sample Registration, is an online registry for physical samples collected for Earth and environmental studies. SESAR generates and administers the International Geo Sample Number IGSN, a unique identifier for samples that is dramatically advancing interoperability amongst information systems for sample-based data. SESAR was developed to provide the complete range of registry services, including definition of IGSN syntax and metadata profiles, registration and validation of name spaces requested by users, tools for users to submit and manage sample metadata, validation of submitted metadata, generation and validation of the unique identifiers, archiving of sample metadata, and public or private access to the sample metadata catalog. With the development of SESAR v3, we placed particular emphasis on creating enhanced tools that make metadata submission easier and more efficient for users, and that provide superior functionality for users to manage metadata of their samples in their private workspace MySESAR. For example, SESAR v3 includes a module where users can generate custom spreadsheet templates to enter metadata for their samples, then upload these templates online for sample registration. Once the content of the template is uploaded, it is displayed online in an editable grid format. Validation rules are executed in real-time on the grid data to ensure data integrity. Other new features of SESAR v3 include the capability to transfer ownership of samples to other SESAR users, the ability to upload and store images and other files in a sample metadata profile, and the tracking of changes to sample metadata profiles. In the next version of SESAR (v3.5), we will further improve the discovery, sharing, registration of samples. For example, we are developing a more comprehensive suite of web services that will allow discovery and registration access to SESAR from external systems. Both batch and individual registrations will be possible

  19. RaPToRS Sample Delivery System

    Science.gov (United States)

    Henchen, Robert; Shibata, Kye; Krieger, Michael; Pogozelski, Edward; Padalino, Stephen; Glebov, Vladimir; Sangster, Craig

    2010-11-01

    At various labs (NIF, LLE, NRL), activated material samples are used to measure reaction properties. The Rapid Pneumatic Transport of Radioactive Samples (RaPToRS) system quickly and safely moves these radioactive samples through a closed PVC tube via airflow. The carrier travels from the reaction chamber to the control and analysis station, pneumatically braking at the outlet. A reversible multiplexer routes samples from various locations near the shot chamber to the analysis station. Also, the multiplexer allows users to remotely load unactivated samples without manually approaching the reaction chamber. All elements of the system (pneumatic drivers, flow control valves, optical position sensors, multiplexers, Geiger counters, and release gates at the analysis station) can be controlled manually or automatically using a custom LabVIEW interface. A prototype is currently operating at NRL in Washington DC. Prospective facilities for Raptors systems include LLE and NIF.

  20. Engineering Software Suite Validates System Design

    Science.gov (United States)

    2007-01-01

    EDAptive Computing Inc.'s (ECI) EDAstar engineering software tool suite, created to capture and validate system design requirements, was significantly funded by NASA's Ames Research Center through five Small Business Innovation Research (SBIR) contracts. These programs specifically developed Syscape, used to capture executable specifications of multi-disciplinary systems, and VectorGen, used to automatically generate tests to ensure system implementations meet specifications. According to the company, the VectorGen tests considerably reduce the time and effort required to validate implementation of components, thereby ensuring their safe and reliable operation. EDASHIELD, an additional product offering from ECI, can be used to diagnose, predict, and correct errors after a system has been deployed using EDASTAR -created models. Initial commercialization for EDASTAR included application by a large prime contractor in a military setting, and customers include various branches within the U.S. Department of Defense, industry giants like the Lockheed Martin Corporation, Science Applications International Corporation, and Ball Aerospace and Technologies Corporation, as well as NASA's Langley and Glenn Research Centers

  1. Validation of the Short Form of the Career Development Inventory with an Iranian High School Sample

    Science.gov (United States)

    Sadeghi, Ahmad; Baghban, Iran; Bahrami, Fatemeh; Ahmadi, Ahmad; Creed, Peter

    2011-01-01

    A short 33-item form of the Career Development Inventory was validated on a sample of 310 Iranian high school students. Factor analysis indicated that attitude and cognitive subscale items loaded on their respective factors, and that internal reliability coefficients at all levels were satisfactory to good. Support for validity was demonstrated by…

  2. Modular microfluidic system for biological sample preparation

    Science.gov (United States)

    Rose, Klint A.; Mariella, Jr., Raymond P.; Bailey, Christopher G.; Ness, Kevin Dean

    2015-09-29

    A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

  3. A Sample Delivery System for Planetary Missions

    Data.gov (United States)

    National Aeronautics and Space Administration — The project will develop, test and characterize the performance of a prototype /sample delivery system (SDS) implemented as an end effector on a robotic arm capable...

  4. Rotary Mode Core Sample System availability improvement

    International Nuclear Information System (INIS)

    Jenkins, W.W.; Bennett, K.L.; Potter, J.D.; Cross, B.T.; Burkes, J.M.; Rogers, A.C.

    1995-01-01

    The Rotary Mode Core Sample System (RMCSS) is used to obtain stratified samples of the waste deposits in single-shell and double-shell waste tanks at the Hanford Site. The samples are used to characterize the waste in support of ongoing and future waste remediation efforts. Four sampling trucks have been developed to obtain these samples. Truck I was the first in operation and is currently being used to obtain samples where the push mode is appropriate (i.e., no rotation of drill). Truck 2 is similar to truck 1, except for added safety features, and is in operation to obtain samples using either a push mode or rotary drill mode. Trucks 3 and 4 are now being fabricated to be essentially identical to truck 2

  5. Validation of the Cognition Test Battery for Spaceflight in a Sample of Highly Educated Adults.

    Science.gov (United States)

    Moore, Tyler M; Basner, Mathias; Nasrini, Jad; Hermosillo, Emanuel; Kabadi, Sushila; Roalf, David R; McGuire, Sarah; Ecker, Adrian J; Ruparel, Kosha; Port, Allison M; Jackson, Chad T; Dinges, David F; Gur, Ruben C

    2017-10-01

    Neuropsychological changes that may occur due to the environmental and psychological stressors of prolonged spaceflight motivated the development of the Cognition Test Battery. The battery was designed to assess multiple domains of neurocognitive functions linked to specific brain systems. Tests included in Cognition have been validated, but not in high-performing samples comparable to astronauts, which is an essential step toward ensuring their usefulness in long-duration space missions. We administered Cognition (on laptop and iPad) and the WinSCAT, counterbalanced for order and version, in a sample of 96 subjects (50% women; ages 25-56 yr) with at least a Master's degree in science, technology, engineering, or mathematics (STEM). We assessed the associations of age, sex, and administration device with neurocognitive performance, and compared the scores on the Cognition battery with those of WinSCAT. Confirmatory factor analysis compared the structure of the iPad and laptop administration methods using Wald tests. Age was associated with longer response times (mean β = 0.12) and less accurate (mean β = -0.12) performance, women had longer response times on psychomotor (β = 0.62), emotion recognition (β = 0.30), and visuo-spatial (β = 0.48) tasks, men outperformed women on matrix reasoning (β = -0.34), and performance on an iPad was generally faster (mean β = -0.55). The WinSCAT appeared heavily loaded with tasks requiring executive control, whereas Cognition assessed a larger variety of neurocognitive domains. Overall results supported the interpretation of Cognition scores as measuring their intended constructs in high performing astronaut analog samples.Moore TM, Basner M, Nasrini J, Hermosillo E, Kabadi S, Roalf DR, McGuire S, Ecker AJ, Ruparel K, Port AM, Jackson CT, Dinges DF, Gur RC. Validation of the Cognition Test Battery for spaceflight in a sample of highly educated adults. Aerosp Med Hum Perform. 2017; 88(10):937-946.

  6. [Formal sample size calculation and its limited validity in animal studies of medical basic research].

    Science.gov (United States)

    Mayer, B; Muche, R

    2013-01-01

    Animal studies are highly relevant for basic medical research, although their usage is discussed controversially in public. Thus, an optimal sample size for these projects should be aimed at from a biometrical point of view. Statistical sample size calculation is usually the appropriate methodology in planning medical research projects. However, required information is often not valid or only available during the course of an animal experiment. This article critically discusses the validity of formal sample size calculation for animal studies. Within the discussion, some requirements are formulated to fundamentally regulate the process of sample size determination for animal experiments.

  7. Sampling system for a boiling reactor NPP

    International Nuclear Information System (INIS)

    Zabelin, A.I.; Yakovleva, E.D.; Solov'ev, Yu.A.

    1976-01-01

    Investigations and pilot running of the nuclear power plant with a VK-50 boiling reactor reveal the necessity of normalizing the design system of water sampling and of mandatory replacement of the needle-type throttle device by a helical one. A method for designing a helical throttle device has been worked out. The quantitative characteristics of depositions of corrosion products along the line of reactor water sampling are presented. Recommendations are given on the organizaton of the sampling system of a nuclear power plant with BWR type reactors

  8. A long-term validation of the modernised DC-ARC-OES solid-sample method.

    Science.gov (United States)

    Flórián, K; Hassler, J; Förster, O

    2001-12-01

    The validation procedure based on ISO 17025 standard has been used to study and illustrate both the longterm stability of the calibration process of the DC-ARC solid sample spectrometric method and the main validation criteria of the method. In the calculation of the validation characteristics depending on the linearity(calibration), also the fulfilment of predetermining criteria such as normality and homoscedasticity was checked. In order to decide whether there are any trends in the time-variation of the analytical signal or not, also the Neumann test of trend was applied and evaluated. Finally, a comparison with similar validation data of the ETV-ICP-OES method was carried out.

  9. A novel atmospheric tritium sampling system

    Science.gov (United States)

    Qin, Lailai; Xia, Zhenghai; Gu, Shaozhong; Zhang, Dongxun; Bao, Guangliang; Han, Xingbo; Ma, Yuhua; Deng, Ke; Liu, Jiayu; Zhang, Qin; Ma, Zhaowei; Yang, Guo; Liu, Wei; Liu, Guimin

    2018-06-01

    The health hazard of tritium is related to its chemical form. Sampling different chemical forms of tritium simultaneously becomes significant. Here a novel atmospheric tritium sampling system (TS-212) was developed to collect the tritiated water (HTO), tritiated hydrogen (HT) and tritiated methane (CH3T) simultaneously. It consisted of an air inlet system, three parallel connected sampling channels, a hydrogen supply module, a methane supply module and a remote control system. It worked at air flow rate of 1 L/min to 5 L/min, with temperature of catalyst furnace at 200 °C for HT sampling and 400 °C for CH3T sampling. Conversion rates of both HT and CH3T to HTO were larger than 99%. The collecting efficiency of the two-stage trap sets for HTO was larger than 96% in 12 h working-time without being blocked. Therefore, the collected efficiencies of TS-212 are larger than 95% for tritium with different chemical forms in environment. Besides, the remote control system made sampling more intelligent, reducing the operator's work intensity. Based on the performance parameters described above, the TS-212 can be used to sample atmospheric tritium in different chemical forms.

  10. Sampling from a system-theoretic viewpoint

    NARCIS (Netherlands)

    Meinsma, Gjerrit; Mirkin, Leonid

    2009-01-01

    This paper studies a system-theoretic approach to the problem of reconstructing an analog signal from its samples. The idea, borrowed from earlier treatments in the control literature, is to address the problem as a hybrid model-matching problem in which performance is measured by system norms. The

  11. Verification and Validation Issues in Systems of Systems

    Directory of Open Access Journals (Sweden)

    Eric Honour

    2013-11-01

    Full Text Available The cutting edge in systems development today is in the area of "systems of systems" (SoS large networks of inter-related systems that are developed and managed separately, but that also perform collective activities. Such large systems typically involve constituent systems operating with different life cycles, often with uncoordinated evolution. The result is an ever-changing SoS in which adaptation and evolution replace the older engineering paradigm of "development". This short paper presents key thoughts about verification and validation in this environment. Classic verification and validation methods rely on having (a a basis of proof, in requirements and in operational scenarios, and (b a known system configuration to be proven. However, with constant SoS evolution, management of both requirements and system configurations are problematic. Often, it is impossible to maintain a valid set of requirements for the SoS due to the ongoing changes in the constituent systems. Frequently, it is even difficult to maintain a vision of the SoS operational use as users find new ways to adapt the SoS. These features of the SoS result in significant challenges for system proof. In addition to discussing the issues, the paper also indicates some of the solutions that are currently used to prove the SoS.

  12. Validation of human factor engineering integrated system

    International Nuclear Information System (INIS)

    Fang Zhou

    2013-01-01

    Apart from hundreds of thousands of human-machine interface resources, the control room of a nuclear power plant is a complex system integrated with many factors such as procedures, operators, environment, organization and management. In the design stage, these factors are considered by different organizations separately. However, whether above factors could corporate with each other well in operation and whether they have good human factors engineering (HFE) design to avoid human error, should be answered in validation of the HFE integrated system before delivery of the plant. This paper addresses the research and implementation of the ISV technology based on case study. After introduction of the background, process and methodology of ISV, the results of the test are discussed. At last, lessons learned from this research are summarized. (authors)

  13. Active Sensor Configuration Validation for Refrigeration Systems

    DEFF Research Database (Denmark)

    Hovgaard, Tobias Gybel; Blanke, Mogens; Niemann, Hans Henrik

    2010-01-01

    -diagnosis methods falling short on this problem, this paper suggests an active diagnosis procedure to isolate sensor faults at the commissioning stage, before normal operation has started. Using statistical methods, residuals are evaluated versus multiple hypothesis models in a minimization process to uniquely......Major faults in the commissioning phase of refrigeration systems are caused by defects related to sensors. With a number of similar sensors available that do not differ by type but only by spatial location in the plant, interchange of sensors is a common defect. With sensors being used quite...... differently by the control system, fault-finding is difficult in practice and defects are regularly causing commissioning delays at considerable expense. Validation and handling of faults in the sensor configuration are therefore essential to cut costs during commissioning. With passive fault...

  14. Candidate sample acquisition systems for the Rosetta

    International Nuclear Information System (INIS)

    Magnani, P.G.; Gerli, C.; Colombina, G.; Vielmo, P.

    1989-01-01

    The Comet Nucleus Sample Return (CNSR) mission, one of the four cornerstones of the ESA scientific program, is one of the most complex space ventures within the next century, both from technological and deep space exploration point of view. In the Rosetta scenario the sample acquisition phase represents the most critical point for the global mission's success. The proposed paper illustrates the main results obtained in the context of the CNSR-SAS ongoing activity. The main areas covered are related to: (1) sample properties characterization (comet soil model, physical/chemical properties, reference material for testing); (2) concepts identification for coring, shovelling, harpooning and anchoring; (3) preferred concept (trade off among concepts, identification of the preferred configuration); and (4) proposed development activity for gaining the necessary confidence before finalizing the CNSR mission. Particular emphasis will be given to the robotic and flexibility aspects of the identified sample acquisition systems (SAS) configuration, intended as a means for the overall system performance enhancement

  15. An improved sampling system installed for reprocessing

    International Nuclear Information System (INIS)

    Finsterwalder, L.; Zeh, H.

    1979-03-01

    Sampling devices are needed for taking representative samples from individual process containers during the reprocessing of irradiated fuel. The aqueous process stream in a reprocessing plant frequently contains, in addition to the dissolved radioactive materials, more or less small quantities of solid matter fraction of fuel material still remaining undissolved, insoluble fission-, corrosion-, or degradation products as well, in exceptional cases, ion exchange resin or silica gel. The solid matter is deposited partly on the upper surfaces of the sampling system and the radiation due to this makes maintenance and repair of the sampler more difficult. The purpose of the development work was to reduce the chance of accident and the maintenance costs and to lower the radiation exposure of the personnel. A new sampling system was developed and is described. (author)

  16. Sampling system for in vivo ultrasound images

    DEFF Research Database (Denmark)

    Jensen, Jorgen Arendt; Mathorne, Jan

    1991-01-01

    Newly developed algorithms for processing medical ultrasound images use the high frequency sampled transducer signal. This paper describes demands imposed on a sampling system suitable for acquiring such data and gives details about a prototype constructed. It acquires full clinical images...... at a sampling frequency of 20 MHz with a resolution of 12 bits. The prototype can be used for real time image processing. An example of a clinical in vivo image is shown and various aspects of the data acquisition process are discussed....

  17. On sampling and modeling complex systems

    International Nuclear Information System (INIS)

    Marsili, Matteo; Mastromatteo, Iacopo; Roudi, Yasser

    2013-01-01

    The study of complex systems is limited by the fact that only a few variables are accessible for modeling and sampling, which are not necessarily the most relevant ones to explain the system behavior. In addition, empirical data typically undersample the space of possible states. We study a generic framework where a complex system is seen as a system of many interacting degrees of freedom, which are known only in part, that optimize a given function. We show that the underlying distribution with respect to the known variables has the Boltzmann form, with a temperature that depends on the number of unknown variables. In particular, when the influence of the unknown degrees of freedom on the known variables is not too irregular, the temperature decreases as the number of variables increases. This suggests that models can be predictable only when the number of relevant variables is less than a critical threshold. Concerning sampling, we argue that the information that a sample contains on the behavior of the system is quantified by the entropy of the frequency with which different states occur. This allows us to characterize the properties of maximally informative samples: within a simple approximation, the most informative frequency size distributions have power law behavior and Zipf’s law emerges at the crossover between the under sampled regime and the regime where the sample contains enough statistics to make inferences on the behavior of the system. These ideas are illustrated in some applications, showing that they can be used to identify relevant variables or to select the most informative representations of data, e.g. in data clustering. (paper)

  18. Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples.

    Science.gov (United States)

    Mehta, Rohini; Birerdinc, Aybike; Hossain, Noreen; Afendy, Arian; Chandhoke, Vikas; Younossi, Zobair; Baranova, Ancha

    2010-05-21

    Given the epidemic proportions of obesity worldwide and the concurrent prevalence of metabolic syndrome, there is an urgent need for better understanding the underlying mechanisms of metabolic syndrome, in particular, the gene expression differences which may participate in obesity, insulin resistance and the associated series of chronic liver conditions. Real-time PCR (qRT-PCR) is the standard method for studying changes in relative gene expression in different tissues and experimental conditions. However, variations in amount of starting material, enzymatic efficiency and presence of inhibitors can lead to quantification errors. Hence the need for accurate data normalization is vital. Among several known strategies for data normalization, the use of reference genes as an internal control is the most common approach. Recent studies have shown that both obesity and presence of insulin resistance influence an expression of commonly used reference genes in omental fat. In this study we validated candidate reference genes suitable for qRT-PCR profiling experiments using visceral adipose samples from obese and lean individuals. Cross-validation of expression stability of eight selected reference genes using three popular algorithms, GeNorm, NormFinder and BestKeeper found ACTB and RPII as most stable reference genes. We recommend ACTB and RPII as stable reference genes most suitable for gene expression studies of human visceral adipose tissue. The use of these genes as a reference pair may further enhance the robustness of qRT-PCR in this model system.

  19. Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples

    Directory of Open Access Journals (Sweden)

    Afendy Arian

    2010-05-01

    Full Text Available Abstract Background Given the epidemic proportions of obesity worldwide and the concurrent prevalence of metabolic syndrome, there is an urgent need for better understanding the underlying mechanisms of metabolic syndrome, in particular, the gene expression differences which may participate in obesity, insulin resistance and the associated series of chronic liver conditions. Real-time PCR (qRT-PCR is the standard method for studying changes in relative gene expression in different tissues and experimental conditions. However, variations in amount of starting material, enzymatic efficiency and presence of inhibitors can lead to quantification errors. Hence the need for accurate data normalization is vital. Among several known strategies for data normalization, the use of reference genes as an internal control is the most common approach. Recent studies have shown that both obesity and presence of insulin resistance influence an expression of commonly used reference genes in omental fat. In this study we validated candidate reference genes suitable for qRT-PCR profiling experiments using visceral adipose samples from obese and lean individuals. Results Cross-validation of expression stability of eight selected reference genes using three popular algorithms, GeNorm, NormFinder and BestKeeper found ACTB and RPII as most stable reference genes. Conclusions We recommend ACTB and RPII as stable reference genes most suitable for gene expression studies of human visceral adipose tissue. The use of these genes as a reference pair may further enhance the robustness of qRT-PCR in this model system.

  20. Blood Sample Transportation by Pneumatic Transportation Systems

    DEFF Research Database (Denmark)

    Nybo, Mads; Lund, Merete E; Titlestad, Kjell

    2018-01-01

    BACKGROUND: Pneumatic transportation systems (PTSs) are increasingly used for transportation of blood samples to the core laboratory. Many studies have investigated the impact of these systems on different types of analyses, but to elucidate whether PTSs in general are safe for transportation...... analysis, and the hemolysis index). CONCLUSIONS: Owing to their high degree of heterogeneity, the retrieved studies were unable to supply evidence for the safety of using PTSs for blood sample transportation. In consequence, laboratories need to measure and document the actual acceleration forces...

  1. Air sampling system for airborne surveys

    International Nuclear Information System (INIS)

    Jupiter, C.; Tipton, W.J.

    1975-01-01

    An air sampling system has been designed for installation on the Beechcraft King Air A-100 aircraft as a part of the Aerial Radiological Measuring System (ARMS). It is intended for both particle and whole gas sampling. The sampling probe is designed for isokinetic sampling and is mounted on a removable modified escape hatch cover, behind the co-pilot's seat, and extends about two feet forward of the hatch cover in the air stream lines. Directly behind the sampling probe inside the modified hatch cover is an expansion chamber, space for a 5-inch diameter filter paper cassette, and an optional four-stage cascade impactor for particle size distribution measurements. A pair of motors and blower pumps provide the necessary 0.5 atmosphere pressure across the type MSA 1106 B glass fiber filter paper to allow a flow rate of 50 cfm. The MSA 1106 B filter paper is designed to trap sub-micrometer particles with a high efficiency; it was chosen to enable a quantitative measurement of airborne radon daughters, one of the principal sources of background signals when radiological surveys are being performed. A venturi section and pressure gauges allow air flow rate measurements so that airborne contaminant concentrations may be quantified. A whole gas sampler capable of sampling a cubic meter of air is mounted inside the aircraft cabin. A nuclear counting system on board the aircraft provides capability for α, β and γ counting of filter paper samples. Design data are presented and types of survey missions which may be served by this system are described

  2. The LITA Drill and Sample Delivery System

    Science.gov (United States)

    Paulsen, G.; Yoon, S.; Zacny, K.; Wettergreeng, D.; Cabrol, N. A.

    2013-12-01

    The Life in the Atacama (LITA) project has a goal of demonstrating autonomous roving, sample acquisition, delivery and analysis operations in Atacama, Chile. To enable the sample handling requirement, Honeybee Robotics developed a rover-deployed, rotary-percussive, autonomous drill, called the LITA Drill, capable of penetrating to ~80 cm in various formations, capturing and delivering subsurface samples to a 20 cup carousel. The carousel has a built-in capability to press the samples within each cup, and position target cups underneath instruments for analysis. The drill and sample delivery system had to have mass and power requirements consistent with a flight system. The drill weighs 12 kg and uses less than 100 watt of power to penetrate ~80 cm. The LITA Drill auger has been designed with two distinct stages. The lower part has deep and gently sloping flutes for retaining powdered sample, while the upper section has shallow and steep flutes for preventing borehole collapse and for efficient movement of cuttings and fall back material out of the hole. The drill uses the so called 'bite-sampling' approach that is samples are taken in short, 5-10 cm bites. To take the first bite, the drill is lowered onto the ground and upon drilling of the first bite it is then retracted into an auger tube. The auger with the auger tube are then lifted off the ground and positioned next to the carousel. To deposit the sample, the auger is rotated and retracted above the auger tube. The cuttings retained on the flutes are either gravity fed or are brushed off by a passive side brush into the cup. After the sample from the first bite has been deposited, the drill is lowered back into the same hole to take the next bite. This process is repeated until a target depth is reached. The bite sampling is analogous to peck drilling in the machining process where a bit is periodically retracted to clear chips. If there is some fall back into the hole once the auger has cleared the hole, this

  3. Validation of Collett-Lester's Fear of Death Scale in a sample of nursing students

    Directory of Open Access Journals (Sweden)

    Maritza Espinoza Venegas

    Full Text Available This study aims to evaluate the psychometric properties of Collett-Lester's Fear of Death Scale. A sample of 349 nursing students answered Fear of Death and Attitude toward death scales. Content validity was checked by expert review; reliability was proven using Cronbach's alpha; statistical analysis of the items, correlation between items and construct validity were checked by the correlation of the Scale with the Attitude toward death Scale. The multidimensionality of the scale was reviewed through factor analysis with varimax rotation. The Fear of Death Scale possesses good internal consistency and construct validity, confirmed by the significant correlation with the Attitude toward death Scale. Factor analysis partially supports content validity of the subscale items, but presented a modified multidimensional structure that points towards the reconceptualization of the subscales in this sample.

  4. Diagnostic PCR: validation and sample preparation are two sides of the same coin

    DEFF Research Database (Denmark)

    Hoorfar, Jeffrey; Wolffs, Petra; Radstrøm, Peter

    2004-01-01

    Increased use of powerful PCR technology for the routine detection of pathogens has focused attention on the need for international validation and preparation of official non-commercial guidelines. Bacteria of epidemiological importance should be the prime focus, although a "validation...... of quantitative reference DNA material and reagents, production of stringent protocols and tools for thermal cycler performance testing, uncomplicated sample preparation techniques, and extensive ring trials for assessment of the efficacy of selected matrix/pathogen detection protocols....

  5. Validity and Psychometric Properties of Malay Translated Religious Orientation Scale-Revised among Malaysian Adult Samples

    OpenAIRE

    Mohammad Rahim Kamaluddin; Rohany Nasir; Wan Shahrazad Wan Sulaiman; Rozainee Khairudin; Zainah Ahmad Zamani

    2017-01-01

    Religious Orientation Scale-Revised (ROS-R) has been used increasingly as an important measure in psychology of religion based researches and widely administered in cross-cultural settings. Unfortunately, there is no valid and reliable ROS-R available in Malay language to assess religious orientations among Malaysians. With that in mind, the present study aims to validate and document the psychometric properties of Malay translated ROS-R (henceforth, M-ROS-R) among sample of Malay...

  6. Developmental validation of the PowerPlex(®) 21 System.

    Science.gov (United States)

    Ensenberger, Martin G; Hill, Carolyn R; McLaren, Robert S; Sprecher, Cynthia J; Storts, Douglas R

    2014-03-01

    The PowerPlex(®) 21 System is a STR multiplex that has been optimized for casework samples while still being capable of database workflows including direct amplification. The loci included in the multiplex offer increasing overlap with core loci used in different countries and regions throughout the world. The PowerPlex(®) 21 System contains D1S1656, D2S1338, D3S1358, D5S818, D6S1043, D7S820, D8S1179, D12S391, D13S317, D16S539, D18S51, D19S433, D21S11, Amelogenin, CSF1PO, FGA, Penta D, Penta E, TH01, TPOX, and vWA. These loci represent all 13 core CODIS loci in addition to loci commonly used in Asia and Europe. A developmental validation study was completed to document performance capabilities and limitations of the PowerPlex(®) 21 System. Data from this validation work served as the basis for the following conclusions: genotyping of single-source samples was reliable across a range of template DNA concentrations with >95% alleles called at 50 pg. Direct amplification of samples from FTA(®) storage cards was successfully performed using the reagents provided with the system and modified cycling protocols provided in the technical manual. Mixture analysis showed that over 95% of minor alleles were detected at 1:9 ratios. Reaction conditions including volume and annealing temperature as well as the concentrations of primers, DNA polymerase, magnesium, and Master Mix were shown to be optimal and able to withstand moderate variations without affecting system performance. Reproducible results were generated by different users at different sites. Finally, concordance studies showed consistent results when comparing the PowerPlex(®) 21 System with other commercially available STR-genotyping systems. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  7. Verification and validation of control system software

    International Nuclear Information System (INIS)

    Munro, J.K. Jr.; Kisner, R.A.; Bhadtt, S.C.

    1991-01-01

    The following guidelines are proposed for verification and validation (V ampersand V) of nuclear power plant control system software: (a) use risk management to decide what and how much V ampersand V is needed; (b) classify each software application using a scheme that reflects what type and how much V ampersand V is needed; (c) maintain a set of reference documents with current information about each application; (d) use Program Inspection as the initial basic verification method; and (e) establish a deficiencies log for each software application. The following additional practices are strongly recommended: (a) use a computer-based configuration management system to track all aspects of development and maintenance; (b) establish reference baselines of the software, associated reference documents, and development tools at regular intervals during development; (c) use object-oriented design and programming to promote greater software reliability and reuse; (d) provide a copy of the software development environment as part of the package of deliverables; and (e) initiate an effort to use formal methods for preparation of Technical Specifications. The paper provides background information and reasons for the guidelines and recommendations. 3 figs., 3 tabs

  8. A content validated questionnaire for assessment of self reported venous blood sampling practices.

    Science.gov (United States)

    Bölenius, Karin; Brulin, Christine; Grankvist, Kjell; Lindkvist, Marie; Söderberg, Johan

    2012-01-19

    Venous blood sampling is a common procedure in health care. It is strictly regulated by national and international guidelines. Deviations from guidelines due to human mistakes can cause patient harm. Validated questionnaires for health care personnel can be used to assess preventable "near misses"--i.e. potential errors and nonconformities during venous blood sampling practices that could transform into adverse events. However, no validated questionnaire that assesses nonconformities in venous blood sampling has previously been presented. The aim was to test a recently developed questionnaire in self reported venous blood sampling practices for validity and reliability. We developed a questionnaire to assess deviations from best practices during venous blood sampling. The questionnaire contained questions about patient identification, test request management, test tube labeling, test tube handling, information search procedures and frequencies of error reporting. For content validity, the questionnaire was confirmed by experts on questionnaires and venous blood sampling. For reliability, test-retest statistics were used on the questionnaire answered twice. The final venous blood sampling questionnaire included 19 questions out of which 9 had in total 34 underlying items. It was found to have content validity. The test-retest analysis demonstrated that the items were generally stable. In total, 82% of the items fulfilled the reliability acceptance criteria. The questionnaire could be used for assessment of "near miss" practices that could jeopardize patient safety and gives several benefits instead of assessing rare adverse events only. The higher frequencies of "near miss" practices allows for quantitative analysis of the effect of corrective interventions and to benchmark preanalytical quality not only at the laboratory/hospital level but also at the health care unit/hospital ward.

  9. A content validated questionnaire for assessment of self reported venous blood sampling practices

    Directory of Open Access Journals (Sweden)

    Bölenius Karin

    2012-01-01

    Full Text Available Abstract Background Venous blood sampling is a common procedure in health care. It is strictly regulated by national and international guidelines. Deviations from guidelines due to human mistakes can cause patient harm. Validated questionnaires for health care personnel can be used to assess preventable "near misses"--i.e. potential errors and nonconformities during venous blood sampling practices that could transform into adverse events. However, no validated questionnaire that assesses nonconformities in venous blood sampling has previously been presented. The aim was to test a recently developed questionnaire in self reported venous blood sampling practices for validity and reliability. Findings We developed a questionnaire to assess deviations from best practices during venous blood sampling. The questionnaire contained questions about patient identification, test request management, test tube labeling, test tube handling, information search procedures and frequencies of error reporting. For content validity, the questionnaire was confirmed by experts on questionnaires and venous blood sampling. For reliability, test-retest statistics were used on the questionnaire answered twice. The final venous blood sampling questionnaire included 19 questions out of which 9 had in total 34 underlying items. It was found to have content validity. The test-retest analysis demonstrated that the items were generally stable. In total, 82% of the items fulfilled the reliability acceptance criteria. Conclusions The questionnaire could be used for assessment of "near miss" practices that could jeopardize patient safety and gives several benefits instead of assessing rare adverse events only. The higher frequencies of "near miss" practices allows for quantitative analysis of the effect of corrective interventions and to benchmark preanalytical quality not only at the laboratory/hospital level but also at the health care unit/hospital ward.

  10. Examining assumptions regarding valid electronic monitoring of medication therapy: development of a validation framework and its application on a European sample of kidney transplant patients

    Directory of Open Access Journals (Sweden)

    Steiger Jürg

    2008-02-01

    Full Text Available Abstract Background Electronic monitoring (EM is used increasingly to measure medication non-adherence. Unbiased EM assessment requires fulfillment of assumptions. The purpose of this study was to determine assumptions needed for internal and external validity of EM measurement. To test internal validity, we examined if (1 EM equipment functioned correctly, (2 if all EM bottle openings corresponded to actual drug intake, and (3 if EM did not influence a patient's normal adherence behavior. To assess external validity, we examined if there were indications that using EM affected the sample representativeness. Methods We used data from the Supporting Medication Adherence in Renal Transplantation (SMART study, which included 250 adult renal transplant patients whose adherence to immunosuppressive drugs was measured during 3 months with the Medication Event Monitoring System (MEMS. Internal validity was determined by assessing the prevalence of nonfunctioning EM systems, the prevalence of patient-reported discrepancies between cap openings and actual intakes (using contemporaneous notes and interview at the end of the study, and by exploring whether adherence was initially uncharacteristically high and decreased over time (an indication of a possible EM intervention effect. Sample representativeness was examined by screening for differences between participants and non-participants or drop outs on non-adherence. Results Our analysis revealed that some assumptions were not fulfilled: 1 one cap malfunctioned (0.4%, 2 self-reported mismatches between bottle openings and actual drug intake occurred in 62% of the patients (n = 155, and 3 adherence decreased over the first 5 weeks of the monitoring, indicating that EM had a waning intervention effect. Conclusion The validity assumptions presented in this article should be checked in future studies using EM as a measure of medication non-adherence.

  11. Designing an enhanced groundwater sample collection system

    International Nuclear Information System (INIS)

    Schalla, R.

    1994-10-01

    As part of an ongoing technical support mission to achieve excellence and efficiency in environmental restoration activities at the Laboratory for Energy and Health-Related Research (LEHR), Pacific Northwest Laboratory (PNL) provided guidance on the design and construction of monitoring wells and identified the most suitable type of groundwater sampling pump and accessories for monitoring wells. The goal was to utilize a monitoring well design that would allow for hydrologic testing and reduce turbidity to minimize the impact of sampling. The sampling results of the newly designed monitoring wells were clearly superior to those of the previously installed monitoring wells. The new wells exhibited reduced turbidity, in addition to improved access for instrumentation and hydrologic testing. The variable frequency submersible pump was selected as the best choice for obtaining groundwater samples. The literature references are listed at the end of this report. Despite some initial difficulties, the actual performance of the variable frequency, submersible pump and its accessories was effective in reducing sampling time and labor costs, and its ease of use was preferred over the previously used bladder pumps. The surface seals system, called the Dedicator, proved to be useful accessory to prevent surface contamination while providing easy access for water-level measurements and for connecting the pump. Cost savings resulted from the use of the pre-production pumps (beta units) donated by the manufacturer for the demonstration. However, larger savings resulted from shortened field time due to the ease in using the submersible pumps and the surface seal access system. Proper deployment of the monitoring wells also resulted in cost savings and ensured representative samples

  12. Compressive Sensing with Cross-Validation and Stop-Sampling for Sparse Polynomial Chaos Expansions

    Energy Technology Data Exchange (ETDEWEB)

    Huan, Xun; Safta, Cosmin; Sargsyan, Khachik; Vane, Zachary Phillips; Lacaze, Guilhem; Oefelein, Joseph C.; Najm, Habib N.

    2017-07-01

    Compressive sensing is a powerful technique for recovering sparse solutions of underdetermined linear systems, which is often encountered in uncertainty quanti cation analysis of expensive and high-dimensional physical models. We perform numerical investigations employing several com- pressive sensing solvers that target the unconstrained LASSO formulation, with a focus on linear systems that arise in the construction of polynomial chaos expansions. With core solvers of l1 ls, SpaRSA, CGIST, FPC AS, and ADMM, we develop techniques to mitigate over tting through an automated selection of regularization constant based on cross-validation, and a heuristic strategy to guide the stop-sampling decision. Practical recommendations on parameter settings for these tech- niques are provided and discussed. The overall method is applied to a series of numerical examples of increasing complexity, including large eddy simulations of supersonic turbulent jet-in-cross flow involving a 24-dimensional input. Through empirical phase-transition diagrams and convergence plots, we illustrate sparse recovery performance under structures induced by polynomial chaos, accuracy and computational tradeoffs between polynomial bases of different degrees, and practi- cability of conducting compressive sensing for a realistic, high-dimensional physical application. Across test cases studied in this paper, we find ADMM to have demonstrated empirical advantages through consistent lower errors and faster computational times.

  13. Aersol particle losses in sampling systems

    International Nuclear Information System (INIS)

    Fan, B.J.; Wong, F.S.; Ortiz, C.A.; Anand, N.K.; McFarland, A.R.

    1993-01-01

    When aerosols are sampled from stacks and ducts, it is usually necessary to transport them from the point of sampling to a location of collection or analysis. Losses of aerosol particles can occur in the inlet region of the probe, in straight horizontal and vertical tubes and in elbows. For probes in laminary flow, the Saffman lift force can cause substantial losses of particles in a short inlet region. An empirical model has been developed to predict probe inlet losses, which are often on the order of 40% for 10 μm AED particles. A user-friendly PC computer code, DEPOSITION, has been setup to model losses in transport systems. Experiments have been conducted to compare the actual aerosol particle losses in transport systems with those predicted by the DEPOSITION code

  14. Assessing the validity of parenting measures in a sample of chinese adolescents.

    Science.gov (United States)

    Supple, Andrew J; Peterson, Gary W; Bush, Kevin R

    2004-09-01

    The purpose of this study was to assess the construct validity of adolescent-report parenting behavior measures (primarily derived from the Parental Behavior Measure) in a sample of 480 adolescents from Beijing, China. Results suggest that maternal support, monitoring, and autonomy granting were valid measures when assessing maternal socialization strategies and Chinese adolescent development. Measures of punitiveness and love withdrawal demonstrated limited validity, whereas maternal positive induction demonstrated little validity. The major implications of these results are that measures of "negative" parenting that included physical or psychological manipulations may not have salience for the development of Chinese adolescents. Moreover, researchers and clinicians should question the applicability of instruments and measures designed to assess family process when working with individuals in families from diverse cultural backgrounds. Copyright 2004 American Psychological Association

  15. The presentation and preliminary validation of KIWEST using a large sample of Norwegian university staff.

    Science.gov (United States)

    Innstrand, Siw Tone; Christensen, Marit; Undebakke, Kirsti Godal; Svarva, Kyrre

    2015-12-01

    The aim of the present paper is to present and validate a Knowledge-Intensive Work Environment Survey Target (KIWEST), a questionnaire developed for assessing the psychosocial factors among people in knowledge-intensive work environments. The construct validity and reliability of the measurement model where tested on a representative sample of 3066 academic and administrative staff working at one of the largest universities in Norway. Confirmatory factor analysis provided initial support for the convergent validity and internal consistency of the 30 construct KIWEST measurement model. However, discriminant validity tests indicated that some of the constructs might overlap to some degree. Overall, the KIWEST measure showed promising psychometric properties as a psychosocial work environment measure. © 2015 the Nordic Societies of Public Health.

  16. Mobile Variable Depth Sampling System Design Study

    International Nuclear Information System (INIS)

    BOGER, R.M.

    2000-01-01

    A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study

  17. Mobile Variable Depth Sampling System Design Study

    Energy Technology Data Exchange (ETDEWEB)

    BOGER, R.M.

    2000-08-25

    A design study is presented for a mobile, variable depth sampling system (MVDSS) that will support the treatment and immobilization of Hanford LAW and HLW. The sampler can be deployed in a 4-inch tank riser and has a design that is based on requirements identified in the Level 2 Specification (latest revision). The waste feed sequence for the MVDSS is based on Phase 1, Case 3S6 waste feed sequence. Technical information is also presented that supports the design study.

  18. 77 FR 27135 - HACCP Systems Validation

    Science.gov (United States)

    2012-05-09

    ... validation, the journal article should identify E.coli O157:H7 and other pathogens as the hazard that the..., or otherwise processes ground beef may determine that E. coli O157:H7 is not a hazard reasonably... specifications that require that the establishment's suppliers apply validated interventions to address E. coli...

  19. The Psychopathy Q-Sort. Construct Validity Evidence in a Nonclinical Sample

    Science.gov (United States)

    Fowler, Katherine A.; Lilienfeld, Scott O.

    2007-01-01

    Scant research has examined the validity of instruments that permit observer ratings of psychopathy. Using a nonclinical (undergraduate) sample, the authors examined the associations between both self- and observer ratings on a psychopathy prototype (Psychopathy Q-Sort, PQS) and widely used measures of psychopathy, antisocial behavior, and…

  20. School Anxiety Inventory: Reliability and Validity Evidence in a Sample of Slovenian Adolescents

    Science.gov (United States)

    Levpušcek, Melita Puklek; Inglés, Candido J.; Marzo, Juan C.; García-Fernández, Jose M.

    2015-01-01

    The purpose of this study was to examine the reliability and validity of the School Anxiety Inventory (SAI) using a sample of 646 Slovenian adolescents (48% boys), ranging in age from 12 to 19 years. Single confirmatory factor analyses replicated the correlated four-factor structure of scores on the SAI for anxiety-provoking school situations…

  1. Validating the Orientations to Happiness Scale in a Chinese Sample of University Students

    Science.gov (United States)

    Chen, Guo-Hai

    2010-01-01

    This paper examined the reliability and validity of the Orientation to Happiness Scale with a sample of Chinese correspondents. Chinese translation of the Orientation to Happiness Scale, Satisfaction with Life Scale, Temporal Satisfaction with Life Scale, and General Life Satisfaction Scale, were administered to 671 Chinese university students…

  2. Reliability and Validity of the Spanish Adaptation of EOSS, Comparing Normal and Clinical Samples

    Science.gov (United States)

    Valero-Aguayo, Luis; Ferro-Garcia, Rafael; Lopez-Bermudez, Miguel Angel; de Huralde, Ma. Angeles Selva-Lopez

    2012-01-01

    The Experiencing of Self Scale (EOSS) was created for the evaluation of Functional Analytic Psychotherapy (Kohlenberg & Tsai, 1991, 2001, 2008) in relation to the concept of the experience of personal self as socially and verbally constructed. This paper presents a reliability and validity study of the EOSS with a Spanish sample (582…

  3. Evaluation of the Validity of three Criteria for Sampling and Analyzing DST Wastes in Support of Waste Feed Delivery

    International Nuclear Information System (INIS)

    BOGER, R.M.

    2000-01-01

    This document summarizes the analysis of 3 basic criteria for the sampling systems that will provide waste validation samples of tank waste feeds prior to delivery to the waste treatment and immobilization plant where the wastes will be converted to glass forms. The assessed criteria includes sampling through a 4-inch riser, sampling while a mixer pump is operating, and the deployment of an at-tank analysis system. The assessment, based on the Phase I, 3S6 waste feed scenario, indicated that for high level waste, sampling through a 4-inch riser is not required but sampling while mixer pumps are operating will be required. For low activity waste, sampling through a 4-inch riser will be required but sampling while mixer pumps are operating is not required. The assessment indicated that an at-tank analysis system to provide tank mixing/settling (homogeneity) status is not needed since the number of tanks providing LAW feed was expanded and the payment basis in the original privatization contract has been modified

  4. Method validation and uncertainty evaluation of organically bound tritium analysis in environmental sample.

    Science.gov (United States)

    Huang, Yan-Jun; Zeng, Fan; Zhang, Bing; Chen, Chao-Feng; Qin, Hong-Juan; Wu, Lian-Sheng; Guo, Gui-Yin; Yang, Li-Tao; Shang-Guan, Zhi-Hong

    2014-08-01

    The analytical method for organically bound tritium (OBT) was developed in our laboratory. The optimized operating conditions and parameters were established for sample drying, special combustion, distillation, and measurement on a liquid scintillation spectrometer (LSC). Selected types of OBT samples such as rice, corn, rapeseed, fresh lettuce and pork were analyzed for method validation of recovery rate reproducibility, the minimum detection concentration, and the uncertainty for typical low level environmental sample was evaluated. The combustion water recovery rate of different dried environmental sample was kept at about 80%, the minimum detection concentration of OBT ranged from 0.61 to 0.89 Bq/kg (dry weight), depending on the hydrogen content. It showed that this method is suitable for OBT analysis of environmental sample with stable recovery rate, and the combustion water yield of a sample with weight about 40 g would provide sufficient quantity for measurement on LSC. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Design compliance matrix waste sample container filling system for nested, fixed-depth sampling system

    International Nuclear Information System (INIS)

    BOGER, R.M.

    1999-01-01

    This design compliance matrix document provides specific design related functional characteristics, constraints, and requirements for the container filling system that is part of the nested, fixed-depth sampling system. This document addresses performance, external interfaces, ALARA, Authorization Basis, environmental and design code requirements for the container filling system. The container filling system will interface with the waste stream from the fluidic pumping channels of the nested, fixed-depth sampling system and will fill containers with waste that meet the Resource Conservation and Recovery Act (RCRA) criteria for waste that contains volatile and semi-volatile organic materials. The specifications for the nested, fixed-depth sampling system are described in a Level 2 Specification document (HNF-3483, Rev. 1). The basis for this design compliance matrix document is the Tank Waste Remediation System (TWRS) desk instructions for design Compliance matrix documents (PI-CP-008-00, Rev. 0)

  6. Adaptation and Validation of the Sexual Assertiveness Scale (SAS) in a Sample of Male Drug Users.

    Science.gov (United States)

    Vallejo-Medina, Pablo; Sierra, Juan Carlos

    2015-04-21

    The aim of the present study was to adapt and validate the Sexual Assertiveness Scale (SAS) in a sample of male drug users. A sample of 326 male drug users and 322 non-clinical males was selected by cluster sampling and convenience sampling, respectively. Results showed that the scale had good psychometric properties and adequate internal consistency reliability (Initiation = .66, Refusal = .74 and STD-P = .79). An evaluation of the invariance showed strong factor equivalence between both samples. A high and moderate effect of Differential Item Functioning was only found in items 1 and 14 (∆R 2 Nagelkerke = .076 and .037, respectively). We strongly recommend not using item 1 if the goal is to compare the scores of both groups, otherwise the comparison will be biased. Correlations obtained between the CSFQ-14 and the safe sex ratio and the SAS subscales were significant (CI = 95%) and indicated good concurrent validity. Scores of male drug users were similar to those of non-clinical males. Therefore, the adaptation of the SAS to drug users provides enough guarantees for reliable and valid use in both clinical practice and research, although care should be taken with item 1.

  7. Validation and Design Science Research in Information Systems

    NARCIS (Netherlands)

    Sol, H G; Gonzalez, Rafael A.; Mora, Manuel

    2012-01-01

    Validation within design science research in Information Systems (DSRIS) is much debated. The relationship of validation to artifact evaluation is still not clear. This chapter aims at elucidating several components of DSRIS in relation to validation. The role of theory and theorizing are an

  8. Internal validation of the RapidHIT® ID system.

    Science.gov (United States)

    Wiley, Rachel; Sage, Kelly; LaRue, Bobby; Budowle, Bruce

    2017-11-01

    Traditionally, forensic DNA analysis has required highly skilled forensic geneticists in a dedicated laboratory to generate short tandem repeat (STR) profiles. STR profiles are routinely used either to associate or exclude potential donors of forensic biological evidence. The typing of forensic reference samples has become more demanding, especially with the requirement in some jurisdictions to DNA profile arrestees. The Rapid DNA (RDNA) platform, the RapidHIT ® ID (IntegenX ® , Pleasanton, CA), is a fully automated system capable of processing reference samples in approximately 90min with minimal human intervention. Thus, the RapidHIT ID instrument can be deployed to non-laboratory environments (e.g., booking stations) and run by trained atypical personnel such as law enforcement. In order to implement the RapidHIT ID platform, validation studies are needed to define the performance and limitations of the system. Internal validation studies were undertaken with four early-production RapidHIT ID units. Reliable and concordant STR profiles were obtained from reference buccal swabs. Throughout the study, no contamination was observed. The overall first-pass success rate with an "expert-like system" was 72%, which is comparable to another current RDNA platform commercially available. The system's second-pass success rate (involving manual interpretation on first-pass inconclusive results) increased to 90%. Inhibitors (i.e., coffee, smoking tobacco, and chewing tobacco) did not appear to affect typing by the instrument system; however, substrate (i.e., swab type) did impact typing success. Additionally, one desirable feature not available with other Rapid systems is that in the event of a system failed run, a swab can be recovered and subsequently re-analyzed in a new sample cartridge. Therefore, rarely should additional sampling or swab consumption be necessary. The RapidHIT ID system is a robust and reliable tool capable of generating complete STR profiles within

  9. Data validation summary report for the 100-BC-5 Operable Unit Round 9 Groundwater Sampling. Revision 0

    International Nuclear Information System (INIS)

    Kearney, A.T.

    1996-03-01

    The information provided in this validation summary report includes chemical analyses of samples from 100-BC-5 Operable Unit Round 9 Groundwater sampling data. Data from this sampling event and their related quality assurance (QA) samples were reviewed and validated in accordance with Westinghouse Hanford Company (WHC) guidelines at the requested level. Sample analyses included metals, general chemistry, and radiochemistry. Sixty metals samples were analyzed by Quanterra Environmental Services (QES) and Lockheed Analytical Services (LAS). The metals samples were validated using WHC protocols specified in Data Validation Procedures for Chemical Analyses. All qualifiers assigned to the metals data were based on this guidance. The Table 1.1 lists the metals sample delivery group (SDG) that were validated for this sampling event

  10. Integrated System Validation Usability Questionnaire: Computerized Procedures

    International Nuclear Information System (INIS)

    Garcés, Ma. I.; Torralba, B.

    2015-01-01

    The Research and Development (R&D) project on “Theoretical and Methodological Approaches to Integrated System Validation of Control Rooms, 2014-2015”, in which the research activities described in this report are framed, has two main objectives: to develop the items for an usability methodology conceived as a part of the measurement framework for performance-based control room evaluation that the OECD Halden Reactor Project will test in the experiments planned for 2015; and the statistical analysis of the data generated in the experimental activities of the Halden Man-Machine Laboratory (HAMMLAB) facility, with previous usability questionnaires, in 2010 and 2011. In this report, the procedure designed to meet the first goal of the project is described, in particular, the process followed to identify the items related to operating procedures, both computer and paper-based, one of the elements to be included in the usability questionnaire. Three phases are performed, in the first one, the approaches developed by the United States Nuclear Regulatory Commission, NRC, are reviewed, the models used by the nuclear industry and their technical support organizations, mainly, the Electric Power Research Institute, EPRI, are analyzed, and scientist advances are also explored. In the remaining stages, general and specific guidelines for computerized and paper-based procedures are compared and criteria for the preliminary selection of the items that should be incorporated into the usability questionnaire are defined. This proposal will be reviewed and adapted by the Halden Reactor Project to the design of the specific experiments performed in HAMLAB.

  11. Psychometric Validation of the Academic Motivation Scale in a Dental Student Sample.

    Science.gov (United States)

    Orsini, Cesar; Binnie, Vivian; Evans, Phillip; Ledezma, Priscilla; Fuentes, Fernando; Villegas, Maria J

    2015-08-01

    The Academic Motivation Scale is one of the most frequently used instruments to assess academic motivation. It relies on the self-determination theory of human motivation. However, motivation has been understudied in dental education. Therefore, to address the lack of valid instruments to assess academic motivation in dental education and contribute to future research in the field, the aim of this study was to analyze the psychometric properties of this instrument in a sample of dental students. Participants were 989 Chilean undergraduate dental students (86% response rate) who completed a survey containing a Chilean face-valid version of the Spanish Academic Motivation Scale and three other motivation-related instruments to assess the survey's construct and criterion validity. Later, 76 of the students (out of 100 invited) took the survey again to assess its test-retest stability. The instrument's construct validity was supported by the superior goodness of fit of the seven-subscale Academic Motivation Scale over competing models through confirmatory factor analysis and by the expected correlations among its subscales. The concurrent criterion validity was supported by the confirmation of correlations between its subscales and external criteria. Adequate internal consistency and test-retest correlations were also found. The evidence from this study suggests that the Academic Motivation Scale is a preliminarily valid and reliable instrument to assess motivation in the predoctoral dental context. Future research in this area is needed to confirm or refute these results.

  12. Technical note: Instantaneous sampling intervals validated from continuous video observation for behavioral recording of feedlot lambs.

    Science.gov (United States)

    Pullin, A N; Pairis-Garcia, M D; Campbell, B J; Campler, M R; Proudfoot, K L

    2017-11-01

    When considering methodologies for collecting behavioral data, continuous sampling provides the most complete and accurate data set whereas instantaneous sampling can provide similar results and also increase the efficiency of data collection. However, instantaneous time intervals require validation to ensure accurate estimation of the data. Therefore, the objective of this study was to validate scan sampling intervals for lambs housed in a feedlot environment. Feeding, lying, standing, drinking, locomotion, and oral manipulation were measured on 18 crossbred lambs housed in an indoor feedlot facility for 14 h (0600-2000 h). Data from continuous sampling were compared with data from instantaneous scan sampling intervals of 5, 10, 15, and 20 min using a linear regression analysis. Three criteria determined if a time interval accurately estimated behaviors: 1) ≥ 0.90, 2) slope not statistically different from 1 ( > 0.05), and 3) intercept not statistically different from 0 ( > 0.05). Estimations for lying behavior were accurate up to 20-min intervals, whereas feeding and standing behaviors were accurate only at 5-min intervals (i.e., met all 3 regression criteria). Drinking, locomotion, and oral manipulation demonstrated poor associations () for all tested intervals. The results from this study suggest that a 5-min instantaneous sampling interval will accurately estimate lying, feeding, and standing behaviors for lambs housed in a feedlot, whereas continuous sampling is recommended for the remaining behaviors. This methodology will contribute toward the efficiency, accuracy, and transparency of future behavioral data collection in lamb behavior research.

  13. Computer system validation: an overview of official requirements and standards.

    Science.gov (United States)

    Hoffmann, A; Kähny-Simonius, J; Plattner, M; Schmidli-Vckovski, V; Kronseder, C

    1998-02-01

    A brief overview of the relevant documents for companies in the pharmaceutical industry, which are to be taken into consideration to fulfil computer system validation requirements, is presented. We concentrate on official requirements and valid standards in the USA, European Community and Switzerland. There are basically three GMP-guidelines. their interpretations by the associations of interests like APV and PDA as well as the GAMP Suppliers Guide. However, the three GMP-guidelines imply the same philosophy about computer system validation. They describe more a what-to-do approach for validation, whereas the GAMP Suppliers Guide describes a how-to-do validation. Nevertheless, they do not contain major discrepancies.

  14. Preparation and validation of gross alpha/beta samples used in EML's quality assessment program

    International Nuclear Information System (INIS)

    Scarpitta, S.C.

    1997-10-01

    A set of water and filter samples have been incorporated into the existing Environmental Measurements Laboratory's (EML) Quality Assessment Program (QAP) for gross alpha/beta determinations by participating DOE laboratories. The participating laboratories are evaluated by comparing their results with the EML value. The preferred EML method for measuring water and filter samples, described in this report, uses gas flow proportional counters with 2 in. detectors. Procedures for sample preparation, quality control and instrument calibration are presented. Liquid scintillation (LS) counting is an alternative technique that is suitable for quantifying both the alpha ( 241 Am, 230 Th and 238 Pu) and beta ( 90 Sr/ 90 Y) activity concentrations in the solutions used to prepare the QAP water and air filter samples. Three LS counting techniques (Cerenkov, dual dpm and full spectrum analysis) are compared. These techniques may be used to validate the activity concentrations of each component in the alpha/beta solution before the QAP samples are actually prepared

  15. Evaluation of the stability and validity of participant samples recruited over the Internet.

    Science.gov (United States)

    Lieberman, Daniel Z

    2008-12-01

    Research conducted via the Internet has the potential to reach important clinical populations of participants who would not participate in traditional studies. Concerns exist, however, about the validity of samples recruited in this manner, especially when participants are anonymous and never have contact with study staff. This study evaluated two anonymous samples that were recruited over the Internet to test an online program designed to help problem drinkers. The two studies were conducted 3 years apart, and different recruitment strategies were utilized. Despite these differences, the two samples were highly similar in demographic and clinical features. Correlations that have been found between variables in traditional non-anonymous studies were also found in both online samples, supporting the validity of the data that was collected. Appropriate skepticism is required when critically evaluating Internet studies. Nevertheless, the results of this study indicate that it is possible to obtain stable, valid data from anonymous participants over the Internet, even when there are significant differences in the way the participants are obtained.

  16. Sample size determination for disease prevalence studies with partially validated data.

    Science.gov (United States)

    Qiu, Shi-Fang; Poon, Wai-Yin; Tang, Man-Lai

    2016-02-01

    Disease prevalence is an important topic in medical research, and its study is based on data that are obtained by classifying subjects according to whether a disease has been contracted. Classification can be conducted with high-cost gold standard tests or low-cost screening tests, but the latter are subject to the misclassification of subjects. As a compromise between the two, many research studies use partially validated datasets in which all data points are classified by fallible tests, and some of the data points are validated in the sense that they are also classified by the completely accurate gold-standard test. In this article, we investigate the determination of sample sizes for disease prevalence studies with partially validated data. We use two approaches. The first is to find sample sizes that can achieve a pre-specified power of a statistical test at a chosen significance level, and the second is to find sample sizes that can control the width of a confidence interval with a pre-specified confidence level. Empirical studies have been conducted to demonstrate the performance of various testing procedures with the proposed sample sizes. The applicability of the proposed methods are illustrated by a real-data example. © The Author(s) 2012.

  17. Empirically simulated study to compare and validate sampling methods used in aerial surveys of wildlife populations

    NARCIS (Netherlands)

    Khaemba, W.M.; Stein, A.; Rasch, D.; Leeuw, de J.; Georgiadis, N.

    2001-01-01

    This paper compares the distribution, sampling and estimation of abundance for two animal species in an African ecosystem by means of an intensive simulation of the sampling process under a geographical information system (GIS) environment. It focuses on systematic and random sampling designs,

  18. Validity and Psychometric Properties of Malay Translated Religious Orientation Scale-Revised among Malaysian Adult Samples

    Directory of Open Access Journals (Sweden)

    Mohammad Rahim Kamaluddin

    2017-08-01

    Full Text Available Religious Orientation Scale-Revised (ROS-R has been used increasingly as an important measure in psychology of religion based researches and widely administered in cross-cultural settings. Unfortunately, there is no valid and reliable ROS-R available in Malay language to assess religious orientations among Malaysians. With that in mind, the present study aims to validate and document the psychometric properties of Malay translated ROS-R (henceforth, M-ROS-R among sample of Malaysian adults. This study commenced with Forward-Backward translations and was followed by content and face validities. Subsequently, a cross-sectional study was conducted among Malaysian adults (n = 226 using convenience sampling method for the purpose of construct and factorial validations. Later, construct and factorial validity was performed via Exploratory Factor Analysis using Principal Component Analysis with Varimax rotation. Finally, reliability testing was performed to determine the internal consistency of the items which was achieved using Cronbach’s Alpha coefficient method (α. The factor loading consisted of three factors with a total variance of 64.76%. The final version of M-ROS-R consisted of 14 items with Factor 1 (Intrinsic Orientation comprised of 8 items, Factor 2 (Extrinsic-Socially Orientated with 3 items while Factor 3 (Extrinsic-Personally Orientated constituted 3 items. The internal consistency values of the factors ranged between 0.68 and 0.86, indicating the scale is reliable. The intercorrelations between factors were also significant with each other. M-ROS-R was concluded as a valid and reliable scale to measure and assess religious orientations among Malaysians.

  19. Perceived Organizational Justice in Care Services: creation and multi-sample validation of a measure.

    Science.gov (United States)

    Pérez-Arechaederra, Diana; Briones, Elena; Lind, Allan; García-Ortiz, Luis

    2014-02-01

    Organizational justice (OJ) perceptions predict attitudes and behaviors of customers and employees across a broad range of services. Although OJ has proven predictive power and relevance, it has rarely been studied in health care settings. This stems partially from the lack of a reliable and valid measure of patients' OJ in health care encounters. The objective here was to create and validate a measure of patients' OJ. With that purpose, a survey study with two sampling contexts - the U.S. and Spain - was carried out in order to provide a cross-national validation of the scale in two versions: English (Perceived Organizational Justice in Care Services, PJustCS) and Spanish (Percepción de Justicia Organizacional en el Ámbito Sanitario, PJustAS). Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were used to select the appropriate items in the final version of the instrument. Reliability and validity of the measure were tested. A total of 406 patients in the U.S. and 473 patients in Spain participated. The measures used were the newly created scale of Perceived Organizational Justice in Care Services (PJustCS/PJustAS) and scales of patients' Satisfaction, Trust and Global Justice. Factor Analyses supported the four dimensional structure of the instrument for each group. Multigroup CFA substantiated invariant factor loadings and invariant structural models across both samples, hence, supporting that the instrument is applicable in its two versions: English and Spanish. Validation results showed expected positive relations of OJ with patients' satisfaction, trust in clinicians and global perceived justice. These results point out the importance of health care customers' perceived organizational justice in the explanation of health care dynamics. The scale has desirable psychometric properties and shows adequate validity, contributing to the potential development of the area. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Sampled Data Systems Passivity and Discrete Port-Hamiltonian Systems

    NARCIS (Netherlands)

    Stramigioli, Stefano; Secchi, Cristian; Schaft, Arjan J. van der; Fantuzzi, Cesare

    2005-01-01

    In this paper, we present a novel way to approach the interconnection of a continuous and a discrete time physical system. This is done in a way which preserves passivity of the coupled system independently of the sampling time T. This strategy can be used both in the field of telemanipulation, for

  1. [Rosenberg self-esteem scale: validation in a representative sample of Chilean adults].

    Science.gov (United States)

    Rojas-Barahona, Cristian A; Zegers, Beatriz; Förster, Carla E

    2009-06-01

    Self-esteem is positively associated to the well being of people and could be a good mental health indicator. To determine the reliability and validity of the Rosenberg Self-esteem Scale in a Chilean adult sample. The instrument was applied to 473 subjects living in the Metropolitan Region of Santiago, evenly distributed according to gender, age, educational level and income. The Neugarten Life Satisfaction index (LSI-A) was also applied to the sample. Cronbach's alpha for reliability of the scale was 0.754. There was no gender bias and factor analysis grouped items into two factors (5 positive and 5 negative). The instrument had a correlation of 0.455 with the LSI-A. The Rosenberg Self-esteem Scale meets the criteria for validity and reliability of a quality instrument to measure self-esteem in Chile.

  2. Reliability and validity of the Modified Erikson Psychosocial Stage Inventory in diverse samples.

    Science.gov (United States)

    Leidy, N K; Darling-Fisher, C S

    1995-04-01

    The Modified Erikson Psychosocial Stage Inventory (MEPSI) is a relatively simple survey measure designed to assess the strength of psychosocial attributes that arise from progression through Erikson's eight stages of development. The purpose of this study was to employ secondary analysis to evaluate the internal-consistency reliability and construct validity of the MEPSI across four diverse samples: healthy young adults, hemophilic men, healthy older adults, and older adults with chronic obstructive pulmonary disease. Special attention was given to the performance of the measure across gender, with exploratory analyses examining possible age cohort and health status effects. Internal-consistency estimates for the aggregate measure were high, whereas subscale reliability levels varied across age groups. Construct validity was supported across samples. Gender, cohort, and health effects offered interesting psychometric and theoretical insights and direction for further research. Findings indicated that the MEPSI might be a useful instrument for operationalizing and testing Eriksonian developmental theory in adults.

  3. Data Validation Package - June 2016 Groundwater and Surface Water Sampling at the Green River, Utah, Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    Linard, Joshua [USDOE Office of Legacy Management, Washington, DC (United States); Price, Jeffrey [Navarro Research and Engineering, Inc., Las Vegas, NV (United States)

    2016-10-10

    This event included annual sampling of groundwater and surface water locations at the Green River, Utah, Disposal Site. Sampling and analyses were conducted as specified in Sampling and Analysis Plan for US. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated, http://energy.gov/lrnldownloads/sampling-and- analysis-plan-us-department-energy-office-legacy-management-sites). Samples were collected from 15 monitoring wells and two surface locations at the disposal site as specified in the draft 2011 Ground Water Compliance Action Plan for the Green River, Utah, Disposal Site. Planned monitoring locations are shown in Attachment 1, Sampling and Analysis Work Order. A duplicate sample was collected from location 0179. One equipment blank was collected during this sampling event. Water levels were measured at all monitoring wells that were sampled. See Attachment 2, Trip Reports for additional details. The analytical data and associated qualifiers can be viewed in environmental database reports and are also available for viewing with dynamic mapping via the GEMS (Geospatial Environmental Mapping System) website at http://gems.lm.doe.gov/#. No issues were identified during the data validation process that requires additional action or follow-up.

  4. Validation of the TTM processes of change measure for physical activity in an adult French sample.

    Science.gov (United States)

    Bernard, Paquito; Romain, Ahmed-Jérôme; Trouillet, Raphael; Gernigon, Christophe; Nigg, Claudio; Ninot, Gregory

    2014-04-01

    Processes of change (POC) are constructs from the transtheoretical model that propose to examine how people engage in a behavior. However, there is no consensus about a leading model explaining POC and there is no validated French POC scale in physical activity This study aimed to compare the different existing models to validate a French POC scale. Three studies, with 748 subjects included, were carried out to translate the items and evaluate their clarity (study 1, n = 77), to assess the factorial validity (n = 200) and invariance/equivalence (study 2, n = 471), and to analyze the concurrent validity by stage × process analyses (study 3, n = 671). Two models displayed adequate fit to the data; however, based on the Akaike information criterion, the fully correlated five-factor model appeared as the most appropriate to measure POC in physical activity. The invariance/equivalence was also confirmed across genders and student status. Four of the five existing factors discriminated pre-action and post-action stages. These data support the validation of the POC questionnaire in physical activity among a French sample. More research is needed to explore the longitudinal properties of this scale.

  5. Active Listening Attitude Scale (ALAS: Reliability and Validity in a Nationwide Sample of Greek Educators

    Directory of Open Access Journals (Sweden)

    Ntina Kourmousi

    2017-03-01

    Full Text Available The present study examined the Active Listening Attitude Scale (ALAS validity and reliability in a sample of 3955 Greek educators. The sample was randomly split and an exploratory factor analysis (EFA was conducted in the even subsample to evaluate the scale’s construct validity. A confirmatory factor analysis (CFA was performed in the odd subsample to confirm the three-factor model identified by the EFA. The chi square test (χ2 of the model was significant (p < 0.05, due to the large sample size. The root mean square error of approximation (RMSEA, the comparative fit index (CFI and the goodness of fit index (GFI values were 0.079, 0.969 and 0.960, respectively, further supporting the fit of the three-factor model. Cronbach’s alpha coefficient was used to test internal consistency reliability and was satisfactory exceeding 0.72 for ALAS subscales. The intercorrelations of the three subscales were all positive and significant (p < 0.001, ranging from 0.20 to 0.42. Student’s t-tests and the computation of effect sizes revealed that women scored higher on Listening Skill and Conversation Opportunity, while principals and participants trained on mental health promotion scored higher on all three subscales. The analyses confirmed the three-factor model of ALAS and demonstrated its validity and reliability in measuring Greek teachers’ active listening attitudes.

  6. Validity and Reliability the Rowland Universal Dementia Assessment Scale in a Sample of Elderly Women

    Directory of Open Access Journals (Sweden)

    Sousan Salary

    2013-10-01

    Full Text Available Objectives: The present study aims to investigate the validity and reliability of measuring dementia scale in a sample of elderly women has been reviewed. Methods & Materials: This study is descriptive based on what has been designed in which 310 elderly women were participated in this study out of two ranges of Tehran Kahrisak Prison and Tehran Jahandidegan Institute after being received the consent letter to participate in. In this study, samples were selected as available sampling and four questionnaires were used to collect information which was completed as an interview with elderly women. Information obtained has been analyzed using SPSS software and related statistical methods. Results: Based on research findings, mean age of people under study was 76/86 years and the scale reliability were reviewed in convergence method (Quality of Life and Elderly's Depression Questionnaire and divergence (The informant Questionnaire on Cognition Decline in Elderly questionnaire and Mine Mental Status Examination (MMSE. Also, scale validity was 0.792 with Cronbach's alpha method and 0.759 with division method and 76.0 with test-retest method. In addition, factor analysis indicates the saturation of this scale of a factor. Conclusion: The results achieved from this above study indicate that this scale has appropriate reliability and validity among elderly women. Therefore, it seems that planning to do this research will be very effective in clinical and complex population.

  7. Auto-validating von Neumann rejection sampling from small phylogenetic tree spaces

    Directory of Open Access Journals (Sweden)

    York Thomas

    2009-01-01

    Full Text Available Abstract Background In phylogenetic inference one is interested in obtaining samples from the posterior distribution over the tree space on the basis of some observed DNA sequence data. One of the simplest sampling methods is the rejection sampler due to von Neumann. Here we introduce an auto-validating version of the rejection sampler, via interval analysis, to rigorously draw samples from posterior distributions over small phylogenetic tree spaces. Results The posterior samples from the auto-validating sampler are used to rigorously (i estimate posterior probabilities for different rooted topologies based on mitochondrial DNA from human, chimpanzee and gorilla, (ii conduct a non-parametric test of rate variation between protein-coding and tRNA-coding sites from three primates and (iii obtain a posterior estimate of the human-neanderthal divergence time. Conclusion This solves the open problem of rigorously drawing independent and identically distributed samples from the posterior distribution over rooted and unrooted small tree spaces (3 or 4 taxa based on any multiply-aligned sequence data.

  8. Validating internet research: a test of the psychometric equivalence of internet and in-person samples.

    Science.gov (United States)

    Meyerson, Paul; Tryon, Warren W

    2003-11-01

    This study evaluated the psychometric equivalency of Web-based research. The Sexual Boredom Scale was presented via the World-Wide Web along with five additional scales used to validate it. A subset of 533 participants that matched a previously published sample (Watt & Ewing, 1996) on age, gender, and race was identified. An 8 x 8 correlation matrix from the matched Internet sample was compared via structural equation modeling with a similar 8 x 8 correlation matrix from the previously published study. The Internet and previously published samples were psychometrically equivalent. Coefficient alpha values calculated on the matched Internet sample yielded reliability coefficients almost identical to those for the previously published sample. Factors such as computer administration and uncontrollable administration settings did not appear to affect the results. Demographic data indicated an overrepresentation of males by about 6% and Caucasians by about 13% relative to the U.S. Census (2000). A total of 2,230 participants were obtained in about 8 months without remuneration. These results suggest that data collection on the Web is (1) reliable, (2) valid, (3) reasonably representative, (4) cost effective, and (5) efficient.

  9. Validity of the WISC-IV Spanish for a clinically referred sample of Hispanic children.

    Science.gov (United States)

    San Miguel Montes, Liza E; Allen, Daniel N; Puente, Antonio E; Neblina, Cris

    2010-06-01

    The Wechsler Intelligence Scale for Children (WISC) is the most commonly used intelligence test for children. Five years ago, a Spanish version of the WISC-IV was published (WISC-IV Spanish; Wechsler, 2005), but a limited amount of published information is available regarding its utility when assessing clinical samples. The current study included 107 children who were Spanish speaking and of Puerto Rican descent that had been administered the WISC-IV Spanish. They were subdivided into a clinical sample of 35 children with diagnoses of various forms of brain dysfunction (primarily learning disability, attention-deficit/hyperactivity disorder, and epilepsy) and a comparison group made up of 72 normal children who were part of the WISC-IV Spanish version standardization sample. Comparisons between these groups and the standardization sample were performed for the WISC-IV Spanish index and subtest scores. Results indicated that the clinical sample performed worse than the comparison samples on the Working Memory and Processing Speed Indexes, although findings varied to some extent depending on whether the clinical group was compared with the normal comparison group or the standardization sample. These findings provide support for the criterion validity of the WISC-IV Spanish when it is used to assess a clinically referred sample with brain dysfunction.

  10. Automated validation of a computer operating system

    Science.gov (United States)

    Dervage, M. M.; Milberg, B. A.

    1970-01-01

    Programs apply selected input/output loads to complex computer operating system and measure performance of that system under such loads. Technique lends itself to checkout of computer software designed to monitor automated complex industrial systems.

  11. Fault-tolerant clock synchronization validation methodology. [in computer systems

    Science.gov (United States)

    Butler, Ricky W.; Palumbo, Daniel L.; Johnson, Sally C.

    1987-01-01

    A validation method for the synchronization subsystem of a fault-tolerant computer system is presented. The high reliability requirement of flight-crucial systems precludes the use of most traditional validation methods. The method presented utilizes formal design proof to uncover design and coding errors and experimentation to validate the assumptions of the design proof. The experimental method is described and illustrated by validating the clock synchronization system of the Software Implemented Fault Tolerance computer. The design proof of the algorithm includes a theorem that defines the maximum skew between any two nonfaulty clocks in the system in terms of specific system parameters. Most of these parameters are deterministic. One crucial parameter is the upper bound on the clock read error, which is stochastic. The probability that this upper bound is exceeded is calculated from data obtained by the measurement of system parameters. This probability is then included in a detailed reliability analysis of the system.

  12. Preliminary Validation and Verification Plan for CAREM Reactor Protection System

    International Nuclear Information System (INIS)

    Fittipaldi, Ana; Maciel Felix

    2000-01-01

    The purpose of this paper, is to present a preliminary validation and verification plan for a particular architecture proposed for the CAREM reactor protection system with software modules (computer based system).These software modules can be either own design systems or systems based in commercial modules such as programmable logic controllers (PLC) redundant of last generation.During this study, it was seen that this plan can also be used as a validation and verification plan of commercial products (COTS, commercial off the shelf) and/or smart transmitters.The software life cycle proposed and its features are presented, and also the advantages of the preliminary validation and verification plan

  13. Analysis of bioethanol samples through Inductively Coupled Plasma Mass Spectrometry with a total sample consumption system

    Science.gov (United States)

    Sánchez, Carlos; Lienemann, Charles-Philippe; Todolí, Jose-Luis

    2016-10-01

    Bioethanol real samples have been directly analyzed through ICP-MS by means of the so called High Temperature Torch Integrated Sample Introduction System (hTISIS). Because bioethanol samples may contain water, experiments have been carried out in order to determine the effect of ethanol concentration on the ICP-MS response. The ethanol content studied went from 0 to 50%, because higher alcohol concentrations led to carbon deposits on the ICP-MS interface. The spectrometer default spray chamber (double pass) equipped with a glass concentric pneumatic micronebulizer has been taken as the reference system. Two flow regimes have been evaluated: continuous sample aspiration at 25 μL min- 1 and 5 μL air-segmented sample injection. hTISIS temperature has been shown to be critical, in fact ICP-MS sensitivity increased with this variable up to 100-200 °C depending on the solution tested. Higher chamber temperatures led to either a drop in signal or a plateau. Compared with the reference system, the hTISIS improved the sensitivities by a factor included within the 4 to 8 range while average detection limits were 6 times lower for the latter device. Regarding the influence of the ethanol concentration on sensitivity, it has been observed that an increase in the temperature was not enough to eliminate the interferences. It was also necessary to modify the torch position with respect to the ICP-MS interface to overcome them. This fact was likely due to the different extent of ion plasma radial diffusion encountered as a function of the matrix when working at high chamber temperatures. When the torch was moved 1 mm plasma down axis, ethanolic and aqueous solutions provided statistically equal sensitivities. A preconcentration procedure has been applied in order to validate the methodology. It has been found that, under optimum conditions from the point of view of matrix effects, recoveries for spiked samples were close to 100%. Furthermore, analytical concentrations for real

  14. Are samples drawn from Mechanical Turk valid for research on political ideology?

    Directory of Open Access Journals (Sweden)

    Scott Clifford

    2015-12-01

    Full Text Available Amazon’s Mechanical Turk (MTurk is an increasingly popular tool for the recruitment of research subjects. While there has been much focus on the demographic differences between MTurk samples and the national public, we know little about whether liberals and conservatives recruited from MTurk share the same psychological dispositions as their counterparts in the mass public. In the absence of such evidence, some have argued that the selection process involved in joining MTurk invalidates the subject pool for studying questions central to political science. In this paper, we evaluate this claim by comparing a large MTurk sample to two benchmark national samples – one conducted online and one conducted face-to-face. We examine the personality and value-based motivations of political ideology across the three samples. All three samples produce substantively identical results with only minor variation in effect sizes. In short, liberals and conservatives in our MTurk sample closely mirror the psychological divisions of liberals and conservatives in the mass public, though MTurk liberals hold more characteristically liberal values and attitudes than liberals from representative samples. Overall, our results suggest that MTurk is a valid recruitment tool for psychological research on political ideology.

  15. Reliability and consistency of a validated sun exposure questionnaire in a population-based Danish sample.

    Science.gov (United States)

    Køster, B; Søndergaard, J; Nielsen, J B; Olsen, A; Bentzen, J

    2018-06-01

    An important feature of questionnaire validation is reliability. To be able to measure a given concept by questionnaire validly, the reliability needs to be high. The objectives of this study were to examine reliability of attitude and knowledge and behavioral consistency of sunburn in a developed questionnaire for monitoring and evaluating population sun-related behavior. Sun related behavior, attitude and knowledge was measured weekly by a questionnaire in the summer of 2013 among 664 Danes. Reliability was tested in a test-retest design. Consistency of behavioral information was tested similarly in a questionnaire adapted to measure behavior throughout the summer. The response rates for questionnaire 1, 2 and 3 were high and the drop out was not dependent on demographic characteristic. There was at least 73% agreement between sunburns in the measurement week and the entire summer, and a possible sunburn underestimation in questionnaires summarizing the entire summer. The participants underestimated their outdoor exposure in the evaluation covering the entire summer as compared to the measurement week. The reliability of scales measuring attitude and knowledge was high for majority of scales, while consistency in protection behavior was low. To our knowledge, this is the first study to report reliability for a completely validated questionnaire on sun-related behavior in a national random population based sample. Further, we show that attitude and knowledge questions confirmed their validity with good reliability, while consistency of protection behavior in general and in a week's measurement was low.

  16. Data validation summary report for the 100-HR-3 Round 8, Phases 1 and 2 groundwater sampling task

    International Nuclear Information System (INIS)

    1996-01-01

    This report presents a summary of data validation results on groundwater samples collected for the 100-HR-3 Round 8 Groundwater Sampling task. The analyses performed for this project consisted of: metals, general chemistry, and radiochemistry. The laboratories conducting the analyses were Quanterra Environmental Services (QES) and Lockheed Analytical Services. As required by the contract and the WHC statement of work (WHC 1994), data validation was conducted using the Westinghouse data validation procedures for chemical and radiochemical analyses (WHC 1993a and 1993b). Sample results were validated to levels A and D as described in the data validation procedures. At the completion of validation and verification of each data package, a data validation summary was prepared and transmitted with the original documentation to Environmental Restoration Contract (ERC) for inclusion in the project QA record

  17. A Cost-Constrained Sampling Strategy in Support of LAI Product Validation in Mountainous Areas

    Directory of Open Access Journals (Sweden)

    Gaofei Yin

    2016-08-01

    Full Text Available Increasing attention is being paid on leaf area index (LAI retrieval in mountainous areas. Mountainous areas present extreme topographic variability, and are characterized by more spatial heterogeneity and inaccessibility compared with flat terrain. It is difficult to collect representative ground-truth measurements, and the validation of LAI in mountainous areas is still problematic. A cost-constrained sampling strategy (CSS in support of LAI validation was presented in this study. To account for the influence of rugged terrain on implementation cost, a cost-objective function was incorporated to traditional conditioned Latin hypercube (CLH sampling strategy. A case study in Hailuogou, Sichuan province, China was used to assess the efficiency of CSS. Normalized difference vegetation index (NDVI, land cover type, and slope were selected as auxiliary variables to present the variability of LAI in the study area. Results show that CSS can satisfactorily capture the variability across the site extent, while minimizing field efforts. One appealing feature of CSS is that the compromise between representativeness and implementation cost can be regulated according to actual surface heterogeneity and budget constraints, and this makes CSS flexible. Although the proposed method was only validated for the auxiliary variables rather than the LAI measurements, it serves as a starting point for establishing the locations of field plots and facilitates the preparation of field campaigns in mountainous areas.

  18. Validation of the Sexual Orientation Microaggression Inventory in Two Diverse Samples of LGBTQ Youth.

    Science.gov (United States)

    Swann, Gregory; Minshew, Reese; Newcomb, Michael E; Mustanski, Brian

    2016-08-01

    Critical race theory asserts that microaggressions, or low-level, covert acts of aggression, are commonplace in the lives of people of color. These theorists also assert a taxonomy of microaggressions, which includes "microassaults," "microinsults," and "microinvalidations". The theory of microaggressions has been adopted by researchers of LGBTQ communities. This study investigated the three-factor taxonomy as it relates to a diverse sample of LGBTQ youth using the newly developed Sexual Orientation Microaggression Inventory (SOMI). Exploratory factor analysis was used to determine the number of factors that exist in SOMI in a sample of 206 LGBTQ-identifying youth. Follow up confirmatory factor analyses were conducted in order to compare single-factor, unrestricted four-factor, second-order, and bi-factor models in a separate sample of 363 young men who have sex with men. The best fitting model was used to predict victimization, depressive symptoms, and depression diagnosis in order to test validity. The best fitting model was a bi-factor model utilizing 19 of the original 26 items with a general factor and four specific factors representing anti-gay attitudes ("microinsults"), denial of homosexuality, heterosexism ("microinvalidations"), and societal disapproval ("microassaults"). Reliability analyses found that the majority of reliable variance was accounted for by the general factor. The general factor was a significant predictor of victimization and depressive symptoms, as well as unrelated to social desirability, suggesting convergent, criterion-related, and discriminant validity. SOMI emerged as a scale with evidence of validity for assessing exposure to microaggressions in a diverse sample of LGBTQ youth.

  19. Aerobot Sampling and Handling System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Honeybee Robotics proposes to: ?Derive and document the functional and technical requirements for Aerobot surface sampling and sample handling across a range of...

  20. Automatic control system generation for robot design validation

    Science.gov (United States)

    Bacon, James A. (Inventor); English, James D. (Inventor)

    2012-01-01

    The specification and drawings present a new method, system and software product for and apparatus for generating a robotic validation system for a robot design. The robotic validation system for the robot design of a robotic system is automatically generated by converting a robot design into a generic robotic description using a predetermined format, then generating a control system from the generic robotic description and finally updating robot design parameters of the robotic system with an analysis tool using both the generic robot description and the control system.

  1. Validation of Embedded System Verification Models

    NARCIS (Netherlands)

    Marincic, J.; Mader, Angelika H.; Wieringa, Roelf J.

    The result of a model-based requirements verification shows that the model of a system satisfies (or not) formalised system requirements. The verification result is correct only if the model represents the system adequately. No matter what modelling technique we use, what precedes the model

  2. Validation of the EQ-5D in a general population sample in urban China.

    Science.gov (United States)

    Wang, Hong-Mei; Patrick, Donald L; Edwards, Todd C; Skalicky, Anne M; Zeng, Hai-Yan; Gu, Wen-Wen

    2012-02-01

    To evaluate the reliability and validity of the EQ-5D in a general population sample in urban China. Thousand and eight hundred respondents in 18 communities of Hangzhou, China were recruited by multi-stage stratified random sampling. Respondents self-administered a questionnaire including the EQ-5D, the SF-36, and demographic questions. Test-retest reliability at 2-week intervals was evaluated using Kappa coefficient, the intraclass correlation coefficient. The standard error of measurement (SEM) was used to indicate the absolute measurement error. Construct validity was established using convergent, discriminant, and known groups analyses. Complete data for all EQ-5D dimensions were available for 1,747 respondents (97%). Kappa values were from 0.35 to 1.0. The ICCs of test-retest reliability were 0.53 for the EQ-5D index score and 0.87 for the EQ VAS score. The SEM values were 0.13 (9.22% range) and 4.20 (4.20% range) for the EQ-5D index and EQ VAS scores, respectively. The Pearson's correlation coefficients between the EQ-5D and the SF-36 were stronger between comparable dimensions than those between less comparable dimensions, demonstrating convergent and discriminant evidence of construct validity. The Chinese EQ-5D distinguished well between known groups: respondents who reported poor general health and chronic diseases had worse HRQoL than those without. Older people, females, people widowed or divorced, and those with a lower socioeconomic status reported poorer HRQoL. Respondents reporting no problems on any EQ-5D dimension had better scores on the SF-36 summary scores than those reporting problems. The Chinese version of the EQ-5D demonstrated acceptable construct validity and fair to moderate levels of test-retest reliability in an urban general population in China.

  3. Method validation to determine total alpha beta emitters in water samples using LSC

    International Nuclear Information System (INIS)

    Al-Masri, M. S.; Nashawati, A.; Al-akel, B.; Saaid, S.

    2006-06-01

    In this work a method was validated to determine gross alpha and beta emitters in water samples using liquid scintillation counter. 200 ml of water from each sample were evaporated to 20 ml and 8 ml of them were mixed with 12 ml of the suitable cocktail to be measured by liquid scintillation counter Wallac Winspectral 1414. The lower detection limit by this method (LDL) was 0.33 DPM for total alpha emitters and 1.3 DPM for total beta emitters. and the reproducibility limit was (± 2.32 DPM) and (±1.41 DPM) for total alpha and beta emitters respectively, and the repeatability limit was (±2.19 DPM) and (±1.11 DPM) for total alpha and beta emitters respectively. The method is easy and fast because of the simple preparation steps and the large number of samples that can be measured at the same time. In addition, many real samples and standard samples were analyzed by the method and showed accurate results so it was concluded that the method can be used with various water samples. (author)

  4. Reliability and consistency of a validated sun exposure questionnaire in a population-based Danish sample

    Directory of Open Access Journals (Sweden)

    B. Køster

    2018-06-01

    Full Text Available An important feature of questionnaire validation is reliability. To be able to measure a given concept by questionnaire validly, the reliability needs to be high.The objectives of this study were to examine reliability of attitude and knowledge and behavioral consistency of sunburn in a developed questionnaire for monitoring and evaluating population sun-related behavior.Sun related behavior, attitude and knowledge was measured weekly by a questionnaire in the summer of 2013 among 664 Danes. Reliability was tested in a test-retest design. Consistency of behavioral information was tested similarly in a questionnaire adapted to measure behavior throughout the summer.The response rates for questionnaire 1, 2 and 3 were high and the drop out was not dependent on demographic characteristic. There was at least 73% agreement between sunburns in the measurement week and the entire summer, and a possible sunburn underestimation in questionnaires summarizing the entire summer. The participants underestimated their outdoor exposure in the evaluation covering the entire summer as compared to the measurement week. The reliability of scales measuring attitude and knowledge was high for majority of scales, while consistency in protection behavior was low.To our knowledge, this is the first study to report reliability for a completely validated questionnaire on sun-related behavior in a national random population based sample. Further, we show that attitude and knowledge questions confirmed their validity with good reliability, while consistency of protection behavior in general and in a week's measurement was low. Keywords: Questionnaire, Validation, Reliability, Skin cancer, Prevention, Ultraviolet radiation

  5. Development, validation and testing of a skin sampling method for assessment of metal exposure.

    Science.gov (United States)

    Erfani, Behnaz; Midander, Klara; Lidén, Carola; Julander, Anneli

    2017-07-01

    Nickel, cobalt and chromium are frequent skin sensitizers. Skin exposure results in eczema in sensitized individuals, the risk being related to the skin dose. To develop a self-sampling method for quantification of skin exposure to metals, to validate the method, and to assess its feasibility. Defined metal doses (0.01-5 µg) were applied to the fingers of 5 participants. Skin areas (2 cm 2 ) were sampled with 1% HNO 3 , either as 0.1 ml on a swab, or as 0.5 ml on a wipe. Furthermore, 17 participants performed self-sampling by swab after 2 h of leisure activity. Samples were extracted in 1% HNO 3 and analysed by inductively coupled plasma mass spectrometry. The sampling efficiency by swab was 46%, as compared with 93% for acid wipe sampling, for all tested doses. Most metal from the skin dose was detected in the first swab (33-43%). Despite lower sampling efficiency by swab, skin doses of metals following 2 h of leisure activity without hand washing were quantified in all participants, and ranged from 0.0016 to 0.15 µg/cm 2 , from 0.00014 to -0.0020 µg/cm 2 and from 0.00048 to -0.027 µg/cm 2 for nickel, cobalt, and chromium, respectively. The results indicate a future potential of skin sampling by swab to detect and monitor metals on skin by self-sampling. This will contribute to better knowledge of metal skin exposure among dermatitis patients, workers, and the general population. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Further validation of the Multidimensional Fatigue Inventory in a US adult population sample

    Directory of Open Access Journals (Sweden)

    BeLue Rhonda

    2009-12-01

    Full Text Available Abstract Background The Multidimensional Fatigue Inventory (MFI-20 was developed in 1995. Since then, it has been widely used in cancer research and cancer-related illnesses but has never been validated in fatiguing illnesses or in a large US population-selected sample. In this study, we sought to examine the reliability and validity of the MFI-20 in the population of the state of Georgia, USA. Further, we assessed whether the MFI-20 could serve as a complementary diagnostic tool in chronically fatigued and unwell populations. Methods The data derive from a cross-sectional population-based study investigating the prevalence of chronic fatigue syndrome (CFS in Georgia. The study sample was comprised of three diagnostic groups: CFS-like (292, chronically unwell (269, and well (222. Participants completed the MFI-20 along with several other measures of psychosocial functioning, including the Medical Outcomes Survey Short Form-36 (SF-36, the Zung Self-Rating Depression Scale (SDS, and the Spielberger State-Trait Anxiety Inventory (STAI. We assessed the five MFI-20 subscales using several criteria: inter-item correlations, corrected item-total correlations, internal consistency reliability (Cronbach's alpha coefficients, construct validity, discriminant (known-group validity, floor/ceiling effects, and convergent validity through correlations with the SF-36, SDS, and STAI instruments. Results Averaged inter-item correlations ranged from 0.38 to 0.61, indicating no item redundancy. Corrected item-total correlations for all MFI-20 subscales were greater than 0.30, and Cronbach's alpha coefficients achieved an acceptable level of 0.70. No significant floor/ceiling effect was observed. Factor analysis demonstrated factorial complexity. The MFI-20 also distinguished clearly between three diagnostic groups on all subscales. Furthermore, correlations with depression (SDS, anxiety (STAI, and functional impairment (SF-36 demonstrated strong convergent

  7. Determination of methylmercury in marine biota samples with advanced mercury analyzer: method validation.

    Science.gov (United States)

    Azemard, Sabine; Vassileva, Emilia

    2015-06-01

    In this paper, we present a simple, fast and cost-effective method for determination of methyl mercury (MeHg) in marine samples. All important parameters influencing the sample preparation process were investigated and optimized. Full validation of the method was performed in accordance to the ISO-17025 (ISO/IEC, 2005) and Eurachem guidelines. Blanks, selectivity, working range (0.09-3.0ng), recovery (92-108%), intermediate precision (1.7-4.5%), traceability, limit of detection (0.009ng), limit of quantification (0.045ng) and expanded uncertainty (15%, k=2) were assessed. Estimation of the uncertainty contribution of each parameter and the demonstration of traceability of measurement results was provided as well. Furthermore, the selectivity of the method was studied by analyzing the same sample extracts by advanced mercury analyzer (AMA) and gas chromatography-atomic fluorescence spectrometry (GC-AFS). Additional validation of the proposed procedure was effectuated by participation in the IAEA-461 worldwide inter-laboratory comparison exercises. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. Determination of methylmercury in marine sediment samples: Method validation and occurrence data

    International Nuclear Information System (INIS)

    Carrasco, Luis; Vassileva, Emilia

    2015-01-01

    Highlights: • A method for MeHg determination at trace level in marine sediments is completely validated. • Validation is performed according to ISO-17025 and Eurachem guidelines. • The extraction efficiency of four sample preparation procedures is evaluated. • The uncertainty budget is used as a tool for evaluation of main uncertainty contributors. • Comparison with independent methods yields good agreement within stated uncertainty. - Abstract: The determination of methylmercury (MeHg) in sediment samples is a difficult task due to the extremely low MeHg/THg (total mercury) ratio and species interconversion. Here, we present the method validation of a cost-effective fit-for-purpose analytical procedure for the measurement of MeHg in sediments, which is based on aqueous phase ethylation, followed by purge and trap and hyphenated gas chromatography–pyrolysis–atomic fluorescence spectrometry (GC–Py–AFS) separation and detection. Four different extraction techniques, namely acid and alkaline leaching followed by solvent extraction and evaporation, microwave-assisted extraction with 2-mercaptoethanol, and acid leaching, solvent extraction and back extraction into sodium thiosulfate, were examined regarding their potential to selectively extract MeHg from estuarine sediment IAEA-405 certified reference material (CRM). The procedure based on acid leaching with HNO 3 /CuSO 4 , solvent extraction and back extraction into Na 2 S 2 O 3 yielded the highest extraction recovery, i.e., 94 ± 3% and offered the possibility to perform the extraction of a large number of samples in a short time, by eliminating the evaporation step. The artifact formation of MeHg was evaluated by high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC–ICP–MS), using isotopically enriched Me 201 Hg and 202 Hg and it was found to be nonexistent. A full validation approach in line with ISO 17025 and Eurachem guidelines was followed

  9. Determination of methylmercury in marine sediment samples: Method validation and occurrence data

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco, Luis; Vassileva, Emilia, E-mail: e.vasileva-veleva@iaea.org

    2015-01-01

    Highlights: • A method for MeHg determination at trace level in marine sediments is completely validated. • Validation is performed according to ISO-17025 and Eurachem guidelines. • The extraction efficiency of four sample preparation procedures is evaluated. • The uncertainty budget is used as a tool for evaluation of main uncertainty contributors. • Comparison with independent methods yields good agreement within stated uncertainty. - Abstract: The determination of methylmercury (MeHg) in sediment samples is a difficult task due to the extremely low MeHg/THg (total mercury) ratio and species interconversion. Here, we present the method validation of a cost-effective fit-for-purpose analytical procedure for the measurement of MeHg in sediments, which is based on aqueous phase ethylation, followed by purge and trap and hyphenated gas chromatography–pyrolysis–atomic fluorescence spectrometry (GC–Py–AFS) separation and detection. Four different extraction techniques, namely acid and alkaline leaching followed by solvent extraction and evaporation, microwave-assisted extraction with 2-mercaptoethanol, and acid leaching, solvent extraction and back extraction into sodium thiosulfate, were examined regarding their potential to selectively extract MeHg from estuarine sediment IAEA-405 certified reference material (CRM). The procedure based on acid leaching with HNO{sub 3}/CuSO{sub 4}, solvent extraction and back extraction into Na{sub 2}S{sub 2}O{sub 3} yielded the highest extraction recovery, i.e., 94 ± 3% and offered the possibility to perform the extraction of a large number of samples in a short time, by eliminating the evaporation step. The artifact formation of MeHg was evaluated by high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (HPLC–ICP–MS), using isotopically enriched Me{sup 201}Hg and {sup 202}Hg and it was found to be nonexistent. A full validation approach in line with ISO 17025 and

  10. Validation Aspects of Water Treatment Systems for Pharmaceutical ...

    African Journals Online (AJOL)

    The goal of conducting validation is to demonstrate that a process, when operated within established limits, produces a product of consistent and specified quality with a high degree of assurance. Validation of water treatment systems is necessary to obtain water with all desired quality attributes. This also provides a ...

  11. Validated methodology for quantifying infestation levels of dreissenid mussels in environmental DNA (eDNA) samples

    OpenAIRE

    Peñarrubia Lozano, Luis; Alcaraz Cazorla, Carles; Vaate, Abraham bij de; Sanz Ball-llosera, Núria; Pla Zanuy, Carles; Vidal Fàbrega, Oriol; Viñas de Puig, Jordi

    2016-01-01

    The zebra mussel (Dreissena polymorpha Pallas, 1771) and the quagga mussel (D. rostriformis Deshayes, 1838) are successful invasive bivalves with substantial ecological and economic impacts in freshwater systems once they become established. Since their eradication is extremely difficult, their detection at an early stage is crucial to prevent spread. In this study, we optimized and validated a qPCR detection method based on the histone H2B gene to quantify combined infestation levels of zebr...

  12. Validating the Diagnostic Infant and Preschool Assessment Using a Danish Trauma Sample

    DEFF Research Database (Denmark)

    Schandorph Løkkegaard, Sille; Elklit, Ask

    a Danish version of the DIPA using a sample of young children exposed to (potentially) traumatic events. Method: Interviews of caregivers of 100 children exposed to traumas using the DIPA and the Strength and Difficulties Questionnaire (SDQ). One third of the children have witnessed their father stalking...... their mother; one third of the children have been exposed to family violence and taken shelter at a women’s shelter with their mother; and one third of the children have been exposed to maltreatment and are undergoing legal assessments by social services. Expected results: If the concurrent criterion validity...

  13. Validity and reliability of the Academic Motivation Scale in a sample of Slovenian students

    Directory of Open Access Journals (Sweden)

    Melita Puklek Levpušček

    2017-02-01

    Full Text Available In this study we examined construct validity and reliability of the Academic Motivation Scale, College Version (Academic Motivation Scale, AMS-C 28, Vallerand et al., 1992 and its relationship with gender, certainty of study choice and career goals in Slovenian university students. The theoretical basis of AMS is derived from Self-Determination Theory, which identified different types of motivation on a continuum from amotivation to different types of external motivation and intrinsic (self-determined motivation. The AMS measures multidimensional motivational construct and contains seven scales. The validation sample consisted of 324 students of various studies at the University of Ljubljana. Multigroup confirmatory factor analysis showed an acceptable fit of the original 7-factor structure on Slovenian data and measurement invariance across gender. The highest were correlations among the three factors of intrinsic motivation and among the three factors of external motivation. Current certainty of study choice was positively associated with all three factors of intrinsic motivation and identified regulation, and negatively correlated with amotivation. Extrinsic career goals had low to moderate positive correlations with factors of external motivation while intrinsic career goals correlated positively with the three factors of intrinsic motivation, identified and introjected regulation, and negatively with amotivation. Female students had higher scores on intrinsic motivation to accomplish, and identified and introjected regulation than male students. In sum, the AMS C-28 showed good construct and convergent validity and reliability in Slovenian university context.

  14. Cross Validating Ocean Prediction and Monitoring Systems

    National Research Council Canada - National Science Library

    Mooers, Christopher; Meinen, Christopher; Baringer, Molly; Bang, Inkweon; Rhodes, Robert C; Barron, Charlie N; Bub, Frank

    2005-01-01

    With the ongoing development of ocean circulation models and real-time observing systems, routine estimation of the synoptic state of the ocean is becoming feasible for practical and scientific purposes...

  15. Classifying snakebite in South Africa: Validating a scoring system

    African Journals Online (AJOL)

    In addition, coagulopathy may not be identified until the patient manifests with ... To develop and validate a scoring system for managing snakebites in South Africa (SA). Methods. ... that its greatest value is in identifying those patients who do ...

  16. Development of knowledgebase system for assisting signal validation scheme design

    International Nuclear Information System (INIS)

    Kitamura, M.; Baba, T.; Washio, T.; Sugiyama, K.

    1987-01-01

    The purpose of this study is to develop a knowledgebase system to be used as a tool for designing signal validation schemes. The outputs from the signal validation scheme can be used as; (1) auxiliary signals for detecting sensor failures, (2) inputs to advanced instrumentation such as disturbance analysis and diagnosis system or safety parameter display system, and (3) inputs to digital control systems. Conventional signal validation techniques such as comparison of redundant sensors, limit checking, and calibration tests have been employed in nuclear power plants. However, these techniques have serious drawbacks, e.g. needs for extra sensors, vulnerability to common mode failures, limited applicability to continuous monitoring, etc. To alleviate these difficulties, a new signal validation technique has been developed by using the methods called analytic redundancy and parity space. Although the new technique has been proved feasible as far as preliminary tests are concerned, further developments should be made in order to enhance its practical applicability

  17. Validation of a realistic powder sample using data from DMC at PSI

    International Nuclear Information System (INIS)

    Willendrup, Peter; Filges, Uwe; Keller, Lukas; Farhi, Emmanuel; Lefmann, Kim

    2006-01-01

    We present results of a virtual experiment, carried out by means of a McStas simulation of the powder diffractometer DMC at PSI, using the new powder sample component PowderN. This powder component takes tabulated crystallographic input to define realistic powder lines. The simulated output data from the virtual experiment on the compound Na 2 Ca 3 Al 2 F 14 are compared to real measurement data from the DMC instrument. The agreement is very good with respect to peak positions, widths, background intensity and relative peak intensities. This work represents an important step towards reliable virtual experiments and also act as a validation of the PowderN sample component in McStas

  18. Validation of a realistic powder sample using data from DMC at PSI

    Energy Technology Data Exchange (ETDEWEB)

    Willendrup, Peter [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: peter.willendrup@risoe.dk; Filges, Uwe [Laboratory for Development and Methods ETHZ and PSI CH-5232 Villigen PSI (Switzerland); Keller, Lukas [Laboratory for Neutron Scattering ETHZ and PSI CH-5232 Villigen PSI (Switzerland); Farhi, Emmanuel [Institut Laue-Langevin (ILL) Grenoble, 6 rue J. Horowitz, BP 156, 38042 Grenoble Cedex 9 (France); Lefmann, Kim [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)

    2006-11-15

    We present results of a virtual experiment, carried out by means of a McStas simulation of the powder diffractometer DMC at PSI, using the new powder sample component PowderN. This powder component takes tabulated crystallographic input to define realistic powder lines. The simulated output data from the virtual experiment on the compound Na{sub 2}Ca{sub 3}Al{sub 2}F{sub 14} are compared to real measurement data from the DMC instrument. The agreement is very good with respect to peak positions, widths, background intensity and relative peak intensities. This work represents an important step towards reliable virtual experiments and also act as a validation of the PowderN sample component in McStas.

  19. Validation of a realistic powder sample using data from DMC at PSI

    DEFF Research Database (Denmark)

    Willendrup, Peter Kjær; Filges, U.; Keller, L.

    2006-01-01

    We present results of a virtual experiment, carried out by means of a McStas simulation of the powder diffractometer DMC at PSI, using the new powder sample component PowderN. This powder component takes tabulated crystallographic input to define realistic powder lines. The simulated output data...... from the virtual experiment on the compound Na2Ca3Al2F14 are compared to real measurement data from the DMC instrument. The agreement is very good with respect to peak positions, widths, background intensity and relative peak intensities. This work represents an important step towards reliable virtual...... experiments and also act as a validation of the PowderN sample component in McStas....

  20. Validation of an analytical methodology for the quantitative analysis of petroleum hydrocarbons in marine sediment samples

    Directory of Open Access Journals (Sweden)

    Eloy Yordad Companioni Damas

    2009-01-01

    Full Text Available This work describes a validation of an analytical procedure for the analysis of petroleum hydrocarbons in marine sediment samples. The proposed protocol is able to measure n-alkanes and polycyclic aromatic hydrocarbons (PAH in samples at concentrations as low as 30 ng/g, with a precision better than 15% for most of analytes. The extraction efficiency of fortified sediments varied from 65.1 to 105.6% and 59.7 to 97.8%, for n-alkanes and PAH in the ranges: C16 - C32 and fluoranthene - benzo(apyrene, respectively. The analytical protocol was applied to determine petroleum hydrocarbons in sediments collected from a marine coastal zone.

  1. A Geology Sampling System for Small Bodies

    Science.gov (United States)

    Naids, Adam J.; Hood, Anthony D.; Abell, Paul; Graff, Trevor; Buffington, Jesse

    2016-01-01

    Human exploration of microgravity bodies is being investigated as a precursor to a Mars surface mission. Asteroids, comets, dwarf planets, and the moons of Mars all fall into this microgravity category and some are being discussed as potential mission targets. Obtaining geological samples for return to Earth will be a major objective for any mission to a small body. Currently, the knowledge base for geology sampling in microgravity is in its infancy. Humans interacting with non-engineered surfaces in microgravity environment pose unique challenges. In preparation for such missions a team at the NASA Johnson Space Center has been working to gain experience on how to safely obtain numerous sample types in such an environment. This paper describes the type of samples the science community is interested in, highlights notable prototype work, and discusses an integrated geology sampling solution.

  2. A Geology Sampling System for Microgravity Bodies

    Science.gov (United States)

    Hood, Anthony; Naids, Adam

    2016-01-01

    Human exploration of microgravity bodies is being investigated as a precursor to a Mars surface mission. Asteroids, comets, dwarf planets, and the moons of Mars all fall into this microgravity category and some are been discussed as potential mission targets. Obtaining geological samples for return to Earth will be a major objective for any mission to a microgravity body. Currently the knowledge base for geology sampling in microgravity is in its infancy. Humans interacting with non-engineered surfaces in microgravity environment pose unique challenges. In preparation for such missions a team at the NASA Johnson Space Center has been working to gain experience on how to safely obtain numerous sample types in such an environment. This paper describes the type of samples the science community is interested in, highlights notable prototype work, and discusses an integrated geology sampling solution.

  3. Sampling rare events in nonequilibrium and nonstationary systems.

    Science.gov (United States)

    Berryman, Joshua T; Schilling, Tanja

    2010-12-28

    Although many computational methods for rare event sampling exist, this type of calculation is not usually practical for general nonequilibrium conditions, with macroscopically irreversible dynamics and away from both stationary and metastable states. A novel method for calculating the time-series of the probability of a rare event is presented which is designed for these conditions. The method is validated for the cases of the Glauber-Ising model under time-varying shear flow, the Kawasaki-Ising model after a quench into the region between nucleation dominated and spinodal decomposition dominated phase change dynamics, and the parallel open asymmetric exclusion process. The method requires a subdivision of the phase space of the system: it is benchmarked and found to scale well for increasingly fine subdivisions, meaning that it can be applied without detailed foreknowledge of the physically important reaction pathways.

  4. Construct validation of emotional labor scale for a sample of Pakistani corporate employees.

    Science.gov (United States)

    Akhter, Noreen

    2017-02-01

    To translate, adapt and validate emotional labour scale for Pakistani corporate employees. This study was conducted in locale of Rawalpindi and Islamabad from October 2014 to December 2015, and comprised customer service employees of commercial banks and telecommunication companies. It comprised of two independent parts. Part one had two steps. Step one involved translation and adaptation of the instrument. In the second step psychometric properties of the translated scale were established by administering it to customer services employees from commercial banks and the telecommunication sector. Data of the pilot study was analysed by using exploratory factor analysis to extract the initial factor of emotional labour. Part two comprised the main study. Commercial bank employees were included in the sample by using convenient sampling technique. SPSS 20 was used for data analysis. There were 145 participants in the first study and 495 in the second study . Exploratory factor analysis initially generated three-factor model of emotional labour which was further confirmed by confirmatory factor analysis suggesting that emotional labour had three distinct dimensions, i.e. surface acting, deep acting and genuine expressions of emotions. The emotional labour scale was found to be a valid and reliable measure.

  5. Validity and reliability of the European portuguese version of neuropsychiatric inventory in an institutionalized sample.

    Science.gov (United States)

    Ferreira, Ana Rita; Martins, Sonia; Ribeiro, Orquidea; Fernandes, Lia

    2015-01-01

    Neuropsychiatric symptoms are very common in dementia and have been associated with patient and caregiver distress, increased risk of institutionalization and higher costs of care. In this context, the neuropsychiatric inventory (NPI) is the most widely used comprehensive tool designed to measure neuropsychiatric Symptoms in geriatric patients with dementia. The aim of this study was to present the validity and reliability of the European Portuguese version of NPI. A cross-sectional study was carried out with a convenience sample of institutionalized patients (≥ 50 years old) in three nursing homes in Portugal. All patients were also assessed with mini-mental state examination (MMSE) (cognition), geriatric depression scale (GDS) (depression) and adults and older adults functional assessment inventory (IAFAI) (functionality). NPI was administered to a formal caregiver, usually from the clinical staff. Inter-rater and test-retest reliability were assessed in a subsample of 25 randomly selected subjects. The sample included 166 elderly, with a mean age of 80.9 (standard deviation: 10.2) years. Three out of the NPI behavioral items had negative correlations with MMSE: delusions (rs = -0.177, P = 0.024), disinhibition (rs = -0.174, P = 0.026) and aberrant motor activity (rs = -0.182, P = 0.020). The NPI subsection of depression/dysphoria correlated positively with GDS total score (rs = 0.166, P = 0.038). NPI showed good internal consistency (overall α = 0.766; frequency α = 0.737; severity α = 0.734). The inter-rater reliability was excellent (intraclass correlation coefficient (ICC): 1.00, 95% confidence interval (CI) 1.00 - 1.00), as well as test-retest reliability (ICC: 0.91, 95% CI 0.80 - 0.96). The results found for convergent validity, inter-rater and test-retest reliability, showed that this version appears to be a valid and reliable instrument for evaluation of neuropsychiatric symptoms in institutionalized elderly.

  6. Assessing decentering: validation, psychometric properties, and clinical usefulness of the Experiences Questionnaire in a Spanish sample.

    Science.gov (United States)

    Soler, Joaquim; Franquesa, Alba; Feliu-Soler, Albert; Cebolla, Ausias; García-Campayo, Javier; Tejedor, Rosa; Demarzo, Marcelo; Baños, Rosa; Pascual, Juan Carlos; Portella, Maria J

    2014-11-01

    Decentering is defined as the ability to observe one's thoughts and feelings in a detached manner. The Experiences Questionnaire (EQ) is a self-report instrument that originally assessed decentering and rumination. The purpose of this study was to evaluate the psychometric properties of the Spanish version of EQ-Decentering and to explore its clinical usefulness. The 11-item EQ-Decentering subscale was translated into Spanish and psychometric properties were examined in a sample of 921 adult individuals, 231 with psychiatric disorders and 690 without. The subsample of nonpsychiatric participants was also split according to their previous meditative experience (meditative participants, n=341; and nonmeditative participants, n=349). Additionally, differences among these three subgroups were explored to determine clinical validity of the scale. Finally, EQ-Decentering was administered twice in a group of borderline personality disorder, before and after a 10-week mindfulness intervention. Confirmatory factor analysis indicated acceptable model fit, sbχ(2)=243.8836 (p.46; and divergent validity: r<-.35). The scale detected changes in decentering after a 10-session intervention in mindfulness (t=-4.692, p<.00001). Differences among groups were significant (F=134.8, p<.000001), where psychiatric participants showed the lowest scores compared to nonpsychiatric meditative and nonmeditative participants. The Spanish version of the EQ-Decentering is a valid and reliable instrument to assess decentering either in clinical and nonclinical samples. In addition, the findings show that EQ-Decentering seems an adequate outcome instrument to detect changes after mindfulness-based interventions. Copyright © 2014. Published by Elsevier Ltd.

  7. Quantitative system validation in model driven design

    DEFF Research Database (Denmark)

    Hermanns, Hilger; Larsen, Kim Guldstrand; Raskin, Jean-Francois

    2010-01-01

    The European STREP project Quasimodo1 develops theory, techniques and tool components for handling quantitative constraints in model-driven development of real-time embedded systems, covering in particular real-time, hybrid and stochastic aspects. This tutorial highlights the advances made, focus...

  8. Validation of reactor core protection system

    International Nuclear Information System (INIS)

    Lee, Sang-Hoon; Bae, Jong-Sik; Baeg, Seung-Yeob; Cho, Chang-Ho; Kim, Chang-Ho; Kim, Sung-Ho; Kim, Hang-Bae; In, Wang-Kee; Park, Young-Ho

    2008-01-01

    Reactor COre Protection System (RCOPS), an advanced core protection calculator system, is a digitized one which provides core protection function based on two reactor core operation parameters, Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). It generates a reactor trip signal when the core condition exceeds the DNBR or LPD design limit. It consists of four independent channels adapted a two-out-of-four trip logic. System configuration, hardware platform and an improved algorithm of the newly designed core protection calculator system are described in this paper. One channel of RCOPS was implemented as a single channel facility for this R and D project where we performed final integration software testing. To implement custom function blocks, pSET is used. Software test is performed by two methods. The first method is a 'Software Module Test' and the second method is a 'Software Unit Test'. New features include improvement of core thermal margin through a revised on-line DNBR algorithm, resolution of the latching problem of control element assembly signal and addition of the pre-trip alarm generation. The change of the on-line DNBR calculation algorithm is considered to improve the DNBR net margin by 2.5%-3.3%. (author)

  9. Sample Return Systems for Extreme Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — In Phase I we were able to demonstrate that sample return missions utilizing high velocity penetrators (0.1- 1 km/s) could provide substantial new capabilities for...

  10. Standardized sampling system for reactor coolants

    International Nuclear Information System (INIS)

    Divine, J.R.; Munson, L.F.; Nelson, J.L.; McDowell, R.L.; Jankowski, M.W.

    1982-09-01

    A three-pronged approach was developed to reach the objectives of acceptable coolant sampling, assessment of occupational exposure from corrosion products, and model development for the transport and buildup of corrosion products. Emphasis is on sampler design

  11. Sample Return Systems for Extreme Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed work seeks to design, develop and test a hard impact penetrator/sampler that can withstand the hard impact and enable the sample to be returned to...

  12. Validation of the abbreviated Radon Progeny Integrating Sampling Unit (RPISU) method for Mesa County, Colorado

    International Nuclear Information System (INIS)

    Langner, G.H. Jr.

    1987-06-01

    The US Department of Energy (DOE) Office of Remedial Action and Waste Technology established the Technical Measurements Center at the DOE Grand Junction, Colorado, Projects Office to standardize, calibrate, and compare measurements made in support of DOE remedial action programs. Indoor radon-daughter concentration measurements are made to determine whether a structure is in need of remedial action. The Technical Measurements Center conducted this study to validate an abbreviated Radon Progeny Integrated Sampling Unit (RPISU) method of making indoor radon-daughter measurements to determine whether a structure has a radon-daughter concentration (RDC) below the levels specified in various program standards. The Technical Measurements Center established a criterion against which RDC measurements made using the RPISU sampling method are evaluated to determine if sampling can be terminated or whether further measurements are required. This abbreviated RPISU criterion was tested against 317 actual sets of RPISU data from measurements made over an eight-year period in Mesa County, Colorado. The data from each location were tested against a standard that was assumed to be the same as the actual annual average RDC from that location. At only two locations was the criterion found to fail. Using the abbreviated RPISU method, only 0.6% of locations sampled can be expected to be falsely indicated as having annual average RDC levels below a given standard

  13. Validation of the factor structure of the adolescent dissociative experiences scale in a sample of trauma-exposed detained youth.

    Science.gov (United States)

    Kerig, Patricia K; Charak, Ruby; Chaplo, Shannon D; Bennett, Diana C; Armour, Cherie; Modrowski, Crosby A; McGee, Andrew B

    2016-09-01

    The inclusion of a dissociative subtype in the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM–5 ) criteria for the diagnosis of posttraumatic stress disorder (PTSD) has highlighted the need for valid and reliable measures of dissociative symptoms across developmental periods. The Adolescent Dissociative Experiences Scale (A-DES) is 1 of the few measures validated for young persons, but previous studies have yielded inconsistent results regarding its factor structure. Further, research to date on the A-DES has been based upon nonclinical samples of youth or those without a known history of trauma. To address these gaps in the literature, the present study investigated the factor structure and construct validity of the A-DES in a sample of highly trauma-exposed youth involved in the juvenile justice system. A sample of 784 youth (73.7% boys) recruited from a detention center completed self-report measures of trauma exposure and the A-DES, a subset of whom (n = 212) also completed a measure of PTSD symptoms. Confirmatory factor analyses revealed a best fitting 3-factor structure comprised of depersonalization or derealization, amnesia, and loss of conscious control, with configural and metric invariance across gender. Logistic regression analyses indicated that the depersonalization or derealization factor effectively distinguished between those youth who did and did not likely meet criteria for a diagnosis of PTSD as well as those with PTSD who did and did not likely meet criteria for the dissociative subtype. These results provide support for the multidimensionality of the construct of posttraumatic dissociation and contribute to the understanding of the dissociative subtype of PTSD among adolescents. (PsycINFO Database Record PsycINFO Database Record (c) 2016 APA, all rights reserved

  14. Validity of a portable urine refractometer: the effects of sample freezing.

    Science.gov (United States)

    Sparks, S Andy; Close, Graeme L

    2013-01-01

    The use of portable urine osmometers is widespread, but no studies have assessed the validity of this measurement technique. Furthermore, it is unclear what effect freezing has on osmolality. One-hundred participants of mean (±SD) age 25.1 ± 7.6 years, height 1.77 ± 0.1 m and weight 77.1 ± 10.8 kg provided single urine samples that were analysed using freeze point depression (FPD) and refractometry (RI). Samples were then frozen at -80°C (n = 81) and thawed prior to re-analysis. Differences between methods and freezing were determined using Wilcoxon's signed rank test. Relationships between measurements were assessed using intraclass correlation coefficients (ICC) and typical error of estimate (TE). Osmolality was lower (P = 0.001) using RI (634.2 ± 339.8 mOsm · kgH2O(-1)) compared with FPD (656.7 ± 334.1 mOsm · kgH2O(-1)) but the TE was trivial (0.17). Freezing significantly reduced mean osmolality using FPD (656.7 ± 341.1 to 606.5 ± 333.4 mOsm · kgH2O(-1); P < 0.001), but samples were still highly related following freezing (ICC, r = 0.979, P < 0.001, CI = 0.993-0.997; TE = 0.15; and r=0.995, P < 0.001, CI = 0.967-0.986; TE = 0.07 for RI and FPD respectively). Despite mean differences between methods and as a result of freezing, such differences are physiologically trivial. Therefore, the use of RI appears to be a valid measurement tool to determine urine osmolality.

  15. A psychologist's view of validating aviation systems

    Science.gov (United States)

    Stein, Earl S.; Wagner, Dan

    1994-01-01

    All systems, no matter what they are designed to do, have shortcomings that may make them less productive than was hoped during the initial development. Such shortcomings can arise at any stage of development: from conception to the end of the implementation life cycle. While systems failure and errors of a lesser magnitude can occur as a function of mechanical or software breakdown, the majority of such problems, in aviation are usually laid on the shoulders of the human operator and, to a lesser extent, on human factors. The operator bears the responsibility and blame even though, from a human factors perspective, error may have been designed into the system. Human factors is not a new concept in aviation. The name may be new, but the issues related to operators in the loop date back to the industrial revolution of the nineteenth century and certainly to the aviation build-up for World War I. During this first global confrontation, military services from all sides discovered rather quickly that poor selection and training led to drastically increased personnel losses. While hardware design became an issue later, the early efforts were primarily focused on increased care in pilot selection and on their training. This actually involved early labor-intensive simulation, using such devices as sticks and chairs mounted on rope networks which could be manually moved in response to control input. The use of selection criteria and improved training led to more viable person-machine systems. More pilots survived training and their first ten missions in the air, a rule of thumb arrived at by experience which predicted ultimate survival better than any other. This rule was to hold through World War II. At that time, personnel selection and training became very sophisticated based on previous standards. Also, many psychologists were drafted into Army Air Corps programs which were geared towards refining the human factor. However, despite the talent involved in these programs

  16. Rapid surface sampling and archival record system

    Energy Technology Data Exchange (ETDEWEB)

    Barren, E.; Penney, C.M.; Sheldon, R.B. [GE Corporate Research and Development Center, Schenectady, NY (United States)] [and others

    1995-10-01

    A number of contamination sites exist in this country where the area and volume of material to be remediated is very large, approaching or exceeding 10{sup 6} m{sup 2} and 10{sup 6} m{sup 3}. Typically, only a small fraction of this material is actually contaminated. In such cases there is a strong economic motivation to test the material with a sufficient density of measurements to identify which portions are uncontaminated, so extensively they be left in place or be disposed of as uncontaminated waste. Unfortunately, since contamination often varies rapidly from position to position, this procedure can involve upwards of one million measurements per site. The situation is complicated further in many cases by the difficulties of sampling porous surfaces, such as concrete. This report describes a method for sampling concretes in which an immediate distinction can be made between contaminated and uncontaminated surfaces. Sample acquisition and analysis will be automated.

  17. The Pemberton Happiness Index: Validation of the Universal Portuguese version in a large Brazilian sample.

    Science.gov (United States)

    Paiva, Bianca Sakamoto Ribeiro; de Camargos, Mayara Goulart; Demarzo, Marcelo Marcos Piva; Hervás, Gonzalo; Vázquez, Carmelo; Paiva, Carlos Eduardo

    2016-09-01

    The Pemberton Happiness Index (PHI) is a recently developed integrative measure of well-being that includes components of hedonic, eudaimonic, social, and experienced well-being. The PHI has been validated in several languages, but not in Portuguese. Our aim was to cross-culturally adapt the Universal Portuguese version of the PHI and to assess its psychometric properties in a sample of the Brazilian population using online surveys.An expert committee evaluated 2 versions of the PHI previously translated into Portuguese by the original authors using a standardized form for assessment of semantic/idiomatic, cultural, and conceptual equivalence. A pretesting was conducted employing cognitive debriefing methods. In sequence, the expert committee evaluated all the documents and reached a final Universal Portuguese PHI version. For the evaluation of the psychometric properties, the data were collected using online surveys in a cross-sectional study. The study population included healthcare professionals and users of the social network site Facebook from several Brazilian geographic areas. In addition to the PHI, participants completed the Satisfaction with Life Scale (SWLS), Diener and Emmons' Positive and Negative Experience Scale (PNES), Psychological Well-being Scale (PWS), and the Subjective Happiness Scale (SHS). Internal consistency, convergent validity, known-group validity, and test-retest reliability were evaluated. Satisfaction with the previous day was correlated with the 10 items assessing experienced well-being using the Cramer V test. Additionally, a cut-off value of PHI to identify a "happy individual" was defined using receiver-operating characteristic (ROC) curve methodology.Data from 1035 Brazilian participants were analyzed (health professionals = 180; Facebook users = 855). Regarding reliability results, the internal consistency (Cronbach alpha = 0.890 and 0.914) and test-retest (intraclass correlation coefficient = 0.814) were both considered

  18. Quantitative determination and sampling of azathioprine residues for cleaning validation in production area.

    Science.gov (United States)

    Fazio, Tatiana Tatit; Singh, Anil Kumar; Kedor-Hackmann, Erika Rosa Maria; Santoro, Maria Inês Rocha Miritello

    2007-03-12

    Cleaning validation is an integral part of current good manufacturing practices in any pharmaceutical industry. Nowadays, azathioprine and several other pharmacologically potent pharmaceuticals are manufactured in same production area. Carefully designed cleaning validation and its evaluation can ensure that residues of azathioprine will not carry over and cross contaminate the subsequent product. The aim of this study was to validate simple analytical method for verification of residual azathioprine in equipments used in the production area and to confirm efficiency of cleaning procedure. The HPLC method was validated on a LC system using Nova-Pak C18 (3.9 mm x 150 mm, 4 microm) and methanol-water-acetic acid (20:80:1, v/v/v) as mobile phase at a flow rate of 1.0 mL min(-1). UV detection was made at 280 nm. The calibration curve was linear over a concentration range from 2.0 to 22.0 microg mL(-1) with a correlation coefficient of 0.9998. The detection limit (DL) and quantitation limit (QL) were 0.09 and 0.29 microg mL(-1), respectively. The intra-day and inter-day precision expressed as relative standard deviation (R.S.D.) were below 2.0%. The mean recovery of method was 99.19%. The mean extraction-recovery from manufacturing equipments was 83.5%. The developed UV spectrophotometric method could only be used as limit method to qualify or reject cleaning procedure in production area. Nevertheless, the simplicity of spectrophotometric method makes it useful for routine analysis of azathioprine residues on cleaned surface and as an alternative to proposed HPLC method.

  19. Analytical Chemistry Division's sample transaction system

    International Nuclear Information System (INIS)

    Stanton, J.S.; Tilson, P.A.

    1980-10-01

    The Analytical Chemistry Division uses the DECsystem-10 computer for a wide range of tasks: sample management, timekeeping, quality assurance, and data calculation. This document describes the features and operating characteristics of many of the computer programs used by the Division. The descriptions are divided into chapters which cover all of the information about one aspect of the Analytical Chemistry Division's computer processing

  20. Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosa.

    Directory of Open Access Journals (Sweden)

    Nathan V Welham

    2011-03-01

    Full Text Available The vocal fold mucosa is a biomechanically unique tissue comprised of a densely cellular epithelium, superficial to an extracellular matrix (ECM-rich lamina propria. Such ECM-rich tissues are challenging to analyze using proteomic assays, primarily due to extensive crosslinking and glycosylation of the majority of high M(r ECM proteins. In this study, we implemented an LC-MS/MS-based strategy to characterize the rat vocal fold mucosa proteome. Our sample preparation protocol successfully solubilized both proteins and certain high M(r glycoconjugates and resulted in the identification of hundreds of mucosal proteins. A straightforward approach to the treatment of protein identifications attributed to single peptide hits allowed the retention of potentially important low abundance identifications (validated by a cross-sample match and de novo interpretation of relevant spectra while still eliminating potentially spurious identifications (global single peptide hits with no cross-sample match. The resulting vocal fold mucosa proteome was characterized by a wide range of cellular and extracellular proteins spanning 12 functional categories.

  1. Performance test of SAUNA xenon mobile sampling system

    International Nuclear Information System (INIS)

    Hu Dan; Yang Bin; Yang Weigeng; Jia Huaimao; Wang Shilian; Li Qi; Zhao Yungang; Fan Yuanqing; Chen Zhanying; Chang Yinzhong; Liu Shujiang; Zhang Xinjun; Wang Jun

    2011-01-01

    In this article, the structure and basic functions of SAUNA noble gas xenon mobile sampling system are introduced. The sampling capability of this system is about 2.2 mL per day, as a result from a 684-h operation. The system can be transported to designated locations conveniently to collect xenon sample for routine or emergency environment monitoring. (authors)

  2. Validation of a High Sampling Rate Inertial Measurement Unit for Acceleration During Running.

    Science.gov (United States)

    Provot, Thomas; Chiementin, Xavier; Oudin, Emeric; Bolaers, Fabrice; Murer, Sébastien

    2017-08-25

    The musculo-skeletal response of athletes to various activities during training exercises has become a critical issue in order to optimize their performance and minimize injuries. However, dynamic and kinematic measures of an athlete's activity are generally limited by constraints in data collection and technology. Thus, the choice of reliable and accurate sensors is crucial for gathering data in indoor and outdoor conditions. The aim of this study is to validate the use of the accelerometer of a high sampling rate ( 1344 Hz ) Inertial Measurement Unit (IMU) in the frame of running activities. To this end, two validation protocols are imposed: a classical one on a shaker, followed by another one during running, the IMU being attached to a test subject. For each protocol, the response of the IMU Accelerometer (IMUA) is compared to a calibrated industrial accelerometer, considered as the gold standard for dynamic and kinematic data collection. The repeatability, impact of signal frequency and amplitude (on shaker) as well as the influence of speed (while running) are investigated. Results reveal that the IMUA exhibits good repeatability. Coefficient of Variation CV is 1 % 8.58 ± 0.06 m / s 2 on the shaker and 3 % 26.65 ± 0.69 m / s 2 while running. However, the shaker test shows that the IMUA is affected by the signal frequency (error exceeds 10 % beyond 80 Hz ), an observation confirmed by the running test. Nevertheless, the IMUA provides a reliable measure in the range 0-100 Hz, i.e., the most relevant part in the energy spectrum over the range 0-150 Hz during running. In our view, these findings emphasize the validity of IMUs for the measurement of acceleration during running.

  3. Validation of self-reported diabetes in a representative sample of São Paulo city

    Directory of Open Access Journals (Sweden)

    Mariane de Mello Fontanelli

    Full Text Available ABSTRACT OBJECTIVE To validate the self-reported diabetes mellitus in adults and older adults living in the city of São Paulo, Brazil. METHODS We have used data of 569 subjects (284 adults and 285 older adults, participants of the population-based cross-sectional study Inquérito de Saúde do Município de São Paulo (Health Survey of São Paulo. Fasting glucose ≥ 7.0 mmol/L (126 mg/dL and/or use of drugs (oral hypoglycemic and/or insulin defined the diagnosis of diabetes mellitus. We have validated the self-reported diabetes mellitus by calculating the sensitivity, specificity, positive predictive values, and negative predictive values. We have used Poisson regression with robust variance to verify the factors associated with the sensitivity of the self-reported datum. For all analyses, we have considered the sample design of the study. RESULTS The sensitivity of self-reported diabetes mellitus was 63.8% (95%CI 49.2–76.3, specificity was 99.7% (95%CI 99.1–99.9, positive predictive value was 95.5% (95%CI 84.4–98.8, and negative predictive value was 96.9% (95%CI 94.9–98.2. The correct reporting of diabetes mellitus was more prevalent among older adults (PR = 2.0; 95%CI 1.2–3.5 than among adults. CONCLUSIONS The use of the datum of self-reported diabetes mellitus is valid, especially among older adults living in the city of São Paulo. The results highlight the need to track diabetes mellitus in asymptomatic subjects who have one or more risk factors for it, mainly in the adult population of this city.

  4. Examination of the Structural, Convergent, and Incremental Validity of the Reynolds Intellectual Assessment Scales (RIAS) with a Clinical Sample

    Science.gov (United States)

    Nelson, Jason M.; Canivez, Gary L.

    2012-01-01

    Empirical examination of the Reynolds Intellectual Assessment Scales (RIAS; C. R. Reynolds & R. W. Kamphaus, 2003a) has produced mixed results regarding its internal structure and convergent validity. Various aspects of validity of RIAS scores with a sample (N = 521) of adolescents and adults seeking psychological evaluations at a university-based…

  5. Validation of the Falls Efficacy Scale – International in a sample of Portuguese elderly

    Directory of Open Access Journals (Sweden)

    Cristina Maria Alves Marques-Vieira

    Full Text Available ABSTRACT Objective: to translate and adapt Falls Efficacy Scale – International (FES-I. To analyze the psychometric properties of the FES-I Portugal version. Method: psychometric study. Sample consisting of 170 elderly people residing in the Autonomous Region of Madeira. A two- part form was used (sociodemographic characterization and FES-I Portugal. The cross-cultural adaptation was performed and the following psychometric properties were evaluated: validity (construct, predictive, and discriminant, reliability (Cronbach’s alpha, and inter-rater reliability. Results: the results allow us to verify a dimension of less demanding physical activities and another of more demanding physical activities. The inter-rater reliability study was 0.62, with an interclass correlation coefficient of 0.859, for a 95% confidence interval. The internal consistency of the Portuguese version was 0.962. Conclusion: the validity and reliability of the FES-I Portugal are consistent with the original version and proved to be appropriate instruments for evaluating the “impaired walking” and “risk of falls” nursing diagnoses in the older people.

  6. Construct Validity of the MMPI-2-RF Triarchic Psychopathy Scales in Correctional and Collegiate Samples.

    Science.gov (United States)

    Kutchen, Taylor J; Wygant, Dustin B; Tylicki, Jessica L; Dieter, Amy M; Veltri, Carlo O C; Sellbom, Martin

    2017-01-01

    This study examined the MMPI-2-RF (Ben-Porath & Tellegen, 2008/2011) Triarchic Psychopathy scales recently developed by Sellbom et al. ( 2016 ) in 3 separate groups of male correctional inmates and 2 college samples. Participants were administered a diverse battery of psychopathy specific measures (e.g., Psychopathy Checklist-Revised [Hare, 2003 ], Psychopathic Personality Inventory-Revised [Lilienfeld & Widows, 2005 ], Triarchic Psychopathy Measure [Patrick, 2010 ]), omnibus personality and psychopathology measures such as the Personality Assessment Inventory (Morey, 2007 ) and Personality Inventory for DSM-5 (Krueger, Derringer, Markon, Watson, & Skodol, 2012 ), and narrow-band measures that capture conceptually relevant constructs. Our results generally evidenced strong support for the convergent and discriminant validity for the MMPI-2-RF Triarchic scales. Boldness was largely associated with measures of fearless dominance, social potency, and stress immunity. Meanness showed strong relationships with measures of callousness, aggression, externalizing tendencies, and poor interpersonal functioning. Disinhibition exhibited strong associations with poor impulse control, stimulus seeking, and general externalizing proclivities. Our results provide additional construct validation to both the triarchic model and MMPI-2-RF Triarchic scales. Given the widespread use of the MMPI-2-RF in correctional and forensic settings, our results have important implications for clinical assessment in these 2 areas, where psychopathy is a highly relevant construct.

  7. Spanish version validation of the Marihuana Motives Measure in a drug-consuming adolescent sample.

    Science.gov (United States)

    Matali Costa, Josep; Simons, J; Pardo, M; Lleras, M; Pérez, A; Andión, O

    2018-01-15

    Cannabis is the illicit drug mostly widely consumed by adolescents in Spain. The understanding of consumption motives is an important factor for intervention. In Spain, there are no available instruments for their evaluation, hence, the goal of this paper is to study the psychometric properties of the Marihuana Motives Measure (MMM) in a sample of adolescent consumers. Firstly, translation and back-translation was performed. A total of 228 adolescent consumers of cannabis were evaluated. Factorial analysis was conducted, and the reliability of the total scores and of each scale of the questionnaire was studied through Cronbach's alpha. Test-retest reliability was analyzed through interclass correlations. Validity evidence of the MMM was examined through correlations between current cannabis use, subjective consumption effects measured with the Addiction Research Center Inventory (ARCI), and personality measured with the Millon Adolescent Clinical Inventory (MACI). High reliability was observed in total score of the MMM (Cronbach α = .86), and high and moderate reliability for each of the five factors obtained in the factorial analysis of the MMM, Social = .82, Enhancement = .72, Coping = .83, Expansion = .74, and Conformity = .64. Significant correlations were also observed between cannabis consumption motives and subjective effects, and between consumption motives and personality. The Spanish version of the MMM shows a similar factorial structure as the one obtained by the original author, and its measures are reliable and valid for the study of cannabis consumption motives in adolescent consumer population.

  8. Method validation using weighted linear regression models for quantification of UV filters in water samples.

    Science.gov (United States)

    da Silva, Claudia Pereira; Emídio, Elissandro Soares; de Marchi, Mary Rosa Rodrigues

    2015-01-01

    This paper describes the validation of a method consisting of solid-phase extraction followed by gas chromatography-tandem mass spectrometry for the analysis of the ultraviolet (UV) filters benzophenone-3, ethylhexyl salicylate, ethylhexyl methoxycinnamate and octocrylene. The method validation criteria included evaluation of selectivity, analytical curve, trueness, precision, limits of detection and limits of quantification. The non-weighted linear regression model has traditionally been used for calibration, but it is not necessarily the optimal model in all cases. Because the assumption of homoscedasticity was not met for the analytical data in this work, a weighted least squares linear regression was used for the calibration method. The evaluated analytical parameters were satisfactory for the analytes and showed recoveries at four fortification levels between 62% and 107%, with relative standard deviations less than 14%. The detection limits ranged from 7.6 to 24.1 ng L(-1). The proposed method was used to determine the amount of UV filters in water samples from water treatment plants in Araraquara and Jau in São Paulo, Brazil. Copyright © 2014 Elsevier B.V. All rights reserved.

  9. Method validation to measure Strontium-90 in urine sample for internal dosimetry assessment

    International Nuclear Information System (INIS)

    Bitar, A.; Maghrabi, M.; Alhamwi, A.

    2010-12-01

    Occupational individuals exposed at some scientific centers in Syrian Arab Republic to potentially significant intake by ingestion or inhalation during process of producing radiopharmaceutical compounds. The received radioactive intake differs in relation to the amount of radionuclides released during the preparation processes, to the work conditions and to the applying ways of the radiation protection procedures. TLD (Thermoluminescence Dosimeter) is usually used for external radiation monitoring for workers in radioisotope centers. During the external monitoring programme, it was noticed that some workers were exposed to high external dose resultant from radiation accident in their laboratory when preparing Y-90 from Sr-90. For internal dose assessment, chemical method to measure the amount of Sr-90 in urine samples was validated and explained in details in this study. Urine bioassays were carried out and the activities of 90 Sr were determined using liquid scintillation counter. Then, the validated method was used for internal occupational monitoring purposes through the design of internal monitoring programme. The programme was established for four workers who are dealing, twice per month, with an amount of about 20 mCi in each time. At the beginning, theoretical study was done to assess maximum risks for workers. Calculated internal doses showed that it is necessary to apply internal routine monitoring programme for those workers. (author)

  10. Validity and Reliability of the Problem Solving Inventory (PSI in a Nationwide Sample of Greek Educators

    Directory of Open Access Journals (Sweden)

    Ntina Kourmousi

    2016-06-01

    Full Text Available The Problem Solving Inventory (PSI is designed to measure adults’ perceptions of problem-solving ability. The presented study aimed to translate it and assess its reliability and validity in a nationwide sample of 3668 Greek educators. In order to evaluate internal consistency reliability, Cronbach’s alpha coefficient was used. The scale’s construct validity was examined by a confirmatory factor analysis (CFA and by investigating its correlation with the Internality, Powerful others and Chance Multidimensional Locus of Control Scale (IPC LOC Scale, the Rosenberg Self-Esteem Scale (RSES and demographic information. Internal consistency reliability was satisfactory with Cronbach’s alphas ranging from 0.79 to 0.91 for all PSI scales. CFA confirmed that the bi-level model fitted the data well. The root mean square error of approximation (RMSEA, the comparative fit index (CFI and the goodness of fit index (GFI values were 0.030, 0.97 and 0.96, respectively, further confirming the bi-level model and the three-factors construct of the PSI. Intercorrelations and correlation coefficients between the PSI, the IPC LOC Scale and the RSES were significant. Age, sex, and working experience differences were found. In conclusion, the Greek version of the PSI was found to have satisfactory psychometric properties and therefore, it can be used to evaluate Greek teachers’ perceptions of their problem-solving skills.

  11. Systems and methods for self-synchronized digital sampling

    Science.gov (United States)

    Samson, Jr., John R. (Inventor)

    2008-01-01

    Systems and methods for self-synchronized data sampling are provided. In one embodiment, a system for capturing synchronous data samples is provided. The system includes an analog to digital converter adapted to capture signals from one or more sensors and convert the signals into a stream of digital data samples at a sampling frequency determined by a sampling control signal; and a synchronizer coupled to the analog to digital converter and adapted to receive a rotational frequency signal from a rotating machine, wherein the synchronizer is further adapted to generate the sampling control signal, and wherein the sampling control signal is based on the rotational frequency signal.

  12. A validated HPTLC method for determination of terbutaline sulfate in biological samples: Application to pharmacokinetic study

    OpenAIRE

    Faiyazuddin, Md.; Rauf, Abdul; Ahmad, Niyaz; Ahmad, Sayeed; Iqbal, Zeenat; Talegaonkar, Sushma; Bhatnagar, Aseem; Khar, Roop K.; Ahmad, Farhan J.

    2011-01-01

    Terbutaline sulfate (TBS) was assayed in biological samples by validated HPTLC method. Densitometric analysis of TBS was carried out at 366 nm on precoated TLC aluminum plates with silica gel 60F254 as a stationary phase and chloroform–methanol (9.0:1.0, v/v) as a mobile phase. TBS was well resolved at RF 0.34 ± 0.02. In all matrices, the calibration curve appeared linear (r2 ⩾ 0.9943) in the tested range of 100–1000 ng spot−1 with a limit of quantification of 18.35 ng spot−1. Drug recovery f...

  13. Satisfaction with life scale in a representative sample of Spanish adults: validation and normative data.

    Science.gov (United States)

    Vázquez, Carmelo; Duque, Almudena; Hervás, Gonzalo

    2013-01-01

    The Satisfaction with Life Scale (SWLS) is a measure widely used to assess life satisfaction. This paper aims to test its psychometric properties, factor structure, and distribution scores across age, gender, education, and employment status. For this purpose, a representative sample of the Spanish population (N = 2,964) was used. Although analyses showed no significant differences across age or gender, participants with higher education level and those who held an occupation were more satisfied with their lives. Confirmatory factor analysis revealed a unifactorial structure with significant correlations between the SWLS, and subjective happiness and social support. The internal consistency of the scale was .88. Thus, our results indicate that the Spanish version of the SWLS is a valid and reliable measure of life satisfaction within the Spanish context.

  14. Validation of the Pornography Consumption Inventory in a Sample of Male Brazilian University Students.

    Science.gov (United States)

    Baltieri, Danilo Antonio; Aguiar, Ana Saito Junqueira; de Oliveira, Vitor Henrique; de Souza Gatti, Ana Luisa; de Souza Aranha E Silva, Renata Almeida

    2015-01-01

    Few measures are available to examine pornography use constructs, and this can compromise the reliability of statements regarding harmful use of pornography. This study aimed to confirm the factorial validity and internal consistency of the Pornography Consumption Inventory in a sample of male Brazilian university students. The inventory consists of a 4-factor, 15-item, 5-point Likert-type scale. After translation and back-translation of the inventory, it was administered to 100 male medical students. An initial model that included all 15 items of the inventory showed some substandard fit indices. Therefore, another model was tested, excluding an item that had loaded onto two different factors. Goodness-of-fit indices were better for the new model. Overall, findings from this study support using the inventory on Portuguese-speaking individuals. With additional replication across populations, other settings, and treatment-seeking patients, the Pornography Consumption Inventory could also potentially be shortened to 14 items.

  15. Validation of Scales from the Deployment Risk and Resilience Inventory in a Sample of Operation Iraqi Freedom Veterans

    National Research Council Canada - National Science Library

    Vogt, D. S; Proctor, S. P; King, D. W; King, L. A; Vasterling, J. J

    2008-01-01

    .... Although initial evidence for the reliability and validity of DRRI scales based on Gulf War veteran samples is encouraging, evidence with respect to a more contemporary cohort of Operation Iraqi Freedom (OIF...

  16. Modeling and experimental validation of sawing based lander anchoring and sampling methods for asteroid exploration

    Science.gov (United States)

    Zhang, Jun; Dong, Chengcheng; Zhang, Hui; Li, Song; Song, Aiguo

    2018-05-01

    This paper presents a novel lander anchoring system based on sawing method for asteroid exploration. The system is composed of three robotic arms, three cutting discs, and a control system. The discs mounted at the end of the arms are able to penetrate into the rock surface of asteroids. After the discs cut into the rock surface, the self-locking function of the arms provides forces to fix the lander on the surface. Modeling, trajectory planning, simulations, mechanism design, and prototype fabrication of the anchoring system are discussed, respectively. The performances of the system are tested on different kinds of rocks, at different sawing angles, locations, and speeds. Results show that the system can cut 15 mm deep into granite rock in 180 s at sawing angle of 60°, with the average power of 58.41 W, and the "weight on bit" (WOB) of 8.637 N. The 7.8 kg anchoring system is capable of providing omni-directional anchoring forces, at least 225 N normal and 157 N tangent to the surface of the rock. The system has the advantages of low-weight, low energy consumption and balance forces, high anchoring efficiency and reliability, and could enable the lander to move and sample or assist astronauts and robots in walking and sampling on asteroids.

  17. Verification and validation of computer based systems for PFBR

    International Nuclear Information System (INIS)

    Thirugnanamurthy, D.

    2017-01-01

    Verification and Validation (V and V) process is essential to build quality into system. Verification is the process of evaluating a system to determine whether the products of each development phase satisfies the requirements imposed by the previous phase. Validation is the process of evaluating a system at the end of the development process to ensure compliance with the functional, performance and interface requirements. This presentation elaborates the V and V process followed, documents submission requirements in each stage, V and V activities, check list used for reviews in each stage and reports

  18. Validation of the Caregiver Guilt Questionnaire (CGQ) in a sample of British dementia caregivers.

    Science.gov (United States)

    Roach, Louise; Laidlaw, Ken; Gillanders, David; Quinn, Kathryn

    2013-12-01

    Depression is well documented as a key outcome variable for dementia caregivers; however, guilt has been under-researched, which may be in part due to the lack of an appropriate measure. The Caregiver Guilt Questionnaire (CGQ) was originally developed and piloted with a Spanish population but has not yet been tested in an English-speaking population. A cross-sectional postal survey was undertaken with a sample of 221 dementia caregivers in the UK, as part of a larger study of dementia caregiver outcome measures. The five-factor structure identified for the CGQ in the Spanish sample was replicated in this study. The five factors, "guilt about doing wrong by the care recipient," "guilt about failing to meet the challenges of caregiving," 'guilt over experience of negative emotions in relation to caregiving," "guilt about self-care," and "guilt about neglecting other relatives" accounted for 60% of the variance. Internal consistencies for the whole scale and factors were acceptable, and convergent validity was established with the Zarit Burden Interview guilt factor. A higher score on the CGQ was associated with a higher score on the Center for Epidemiological Studies Depression scale (CES-D) and a new cut-off score of 22 was established, which predicted a clinical score on the CES-D with 80.0% sensitivity and 61.5% specificity. The replication of the five-factor structure suggests that these are relevant themes within the feelings of guilt to both Hispanic and British dementia caregivers. The CGQ has been demonstrated to be a valid measure for use with British dementia caregivers and is likely to be of use in clinical and research settings.

  19. Reliability and validity of emergency department triage systems

    NARCIS (Netherlands)

    van der Wulp, I.

    2010-01-01

    Reliability and validity of triage systems is important because this can affect patient safety. In this thesis, these aspects of two emergency department (ED) triage systems were studied as well as methodological aspects in these types of studies. The consistency, reproducibility, and criterion

  20. Model validation studies of solar systems, Phase III. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.; Winn, C.B.

    1978-12-01

    Results obtained from a validation study of the TRNSYS, SIMSHAC, and SOLCOST solar system simulation and design are presented. Also included are comparisons between the FCHART and SOLCOST solar system design programs and some changes that were made to the SOLCOST program. Finally, results obtained from the analysis of several solar radiation models are presented. Separate abstracts were prepared for ten papers.

  1. Reliability and validity of the Positive Mental Health Questionnaire in a sample of Spanish university students.

    Science.gov (United States)

    Roldán-Merino, J; Lluch-Canut, M T; Casas, I; Sanromà-Ortíz, M; Ferré-Grau, C; Sequeira, C; Falcó-Pegueroles, A; Soares, D; Puig-Llobet, M

    2017-03-01

    WHAT IS KNOWN ON THE SUBJECT?: In general, the current studies of positive mental health use questionnaires or parts thereof. However, while these questionnaires evaluate aspects of positive mental health, they fail to measure the construct itself. WHAT DOES THIS PAPER ADD TO EXISTING KNOWLEDGE?: The widespread use and the lack of specific questionnaires for evaluating the positive mental health construct justify the need to measure the robustness of the Positive Mental Health Questionnaire. Also six factors are proposed to measure positive mental health. WHAT ARE THE IMPLICATIONS FOR PRACTICE?: The availability of a good questionnaire to measure positive mental health in university students is useful not only to promote mental health but also to strengthen the curricula of future professionals. Introduction Nursing has a relevant role in managing mental health. It is important to identify and thereafter to enhance positive aspects of mental health among university nursing students. Aim The aim of the present study was to analyse the psychometric properties of the Positive Mental Health Questionnaire (PMHQ) in terms of reliability and validity using confirmatory factor analysis in a sample of university students. Method A cross-sectional study was carried out in a sample of 1091 students at 4 nursing schools in Catalonia, Spain. The reliability of the PMHQ was measured by means of Cronbach's alpha coefficient, and the test-retest stability was measured with the intraclass correlation coefficient (ICC). Confirmatory factor analysis was used to determine the validity of the factorial structure. Results Cronbach's alpha coefficient was satisfactory (>0.70) for four of the six subscales or dimensions and ranged from 0.54 to 0.79. ICC analysis was satisfactory for the six subscales or dimensions. The hypothesis was confirmed in the analysis of the correlations between subclasses and the overall scale, with the strongest correlations being found between the majority of

  2. Consensus of heterogeneous multi-agent systems based on sampled data with a small sampling delay

    International Nuclear Information System (INIS)

    Wang Na; Wu Zhi-Hai; Peng Li

    2014-01-01

    In this paper, consensus problems of heterogeneous multi-agent systems based on sampled data with a small sampling delay are considered. First, a consensus protocol based on sampled data with a small sampling delay for heterogeneous multi-agent systems is proposed. Then, the algebra graph theory, the matrix method, the stability theory of linear systems, and some other techniques are employed to derive the necessary and sufficient conditions guaranteeing heterogeneous multi-agent systems to asymptotically achieve the stationary consensus. Finally, simulations are performed to demonstrate the correctness of the theoretical results. (interdisciplinary physics and related areas of science and technology)

  3. Solar-Diesel Hybrid Power System Optimization and Experimental Validation

    Science.gov (United States)

    Jacobus, Headley Stewart

    As of 2008 1.46 billion people, or 22 percent of the World's population, were without electricity. Many of these people live in remote areas where decentralized generation is the only method of electrification. Most mini-grids are powered by diesel generators, but new hybrid power systems are becoming a reliable method to incorporate renewable energy while also reducing total system cost. This thesis quantifies the measurable Operational Costs for an experimental hybrid power system in Sierra Leone. Two software programs, Hybrid2 and HOMER, are used during the system design and subsequent analysis. Experimental data from the installed system is used to validate the two programs and to quantify the savings created by each component within the hybrid system. This thesis bridges the gap between design optimization studies that frequently lack subsequent validation and experimental hybrid system performance studies.

  4. Validation and clinical application of a nested PCR for paracoccidioidomycosis diagnosis in clinical samples from Colombian patients.

    Science.gov (United States)

    Gaviria, Marcela; Rivera, Vanessa; Muñoz-Cadavid, Cesar; Cano, Luz Elena; Naranjo, Tonny Williams

    2015-01-01

    Paracoccidioidomycosis is a systemic and endemic mycosis, restricted to tropical and subtropical areas of Latin America. The infection is caused by the thermal dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii. The diagnosis of paracoccidioidomycosis is usually performed by microscopic examination, culture and immunodiagnostic tests to respiratory specimens, body fluids and/or biopsies; however these methods require laboratory personnel with experience and several days to produce a result. In the present study, we have validated and evaluated a nested PCR assay targeting the gene encoding the Paracoccidioides gp43 membrane protein in 191 clinical samples: 115 samples from patients with proven infections other than paracoccidioidomycosis, 51 samples as negative controls, and 25 samples from patients diagnosed with paracoccidioidomycosis. Additionally, the specificity of the nested PCR assay was also evaluated using purified DNA isolated from cultures of different microorganisms (n=35) previously identified by culture and/or sequencing. The results showed that in our hands, this nested PCR assay for gp43 protein showed specificity and sensitivity rates of 100%. The optimized nested PCR conditions in our laboratory allowed detection down to 1fg of P. brasiliensis DNA. Copyright © 2015 Elsevier Editora Ltda. All rights reserved.

  5. Cluster designs to assess the prevalence of acute malnutrition by lot quality assurance sampling: a validation study by computer simulation.

    Science.gov (United States)

    Olives, Casey; Pagano, Marcello; Deitchler, Megan; Hedt, Bethany L; Egge, Kari; Valadez, Joseph J

    2009-04-01

    Traditional lot quality assurance sampling (LQAS) methods require simple random sampling to guarantee valid results. However, cluster sampling has been proposed to reduce the number of random starting points. This study uses simulations to examine the classification error of two such designs, a 67x3 (67 clusters of three observations) and a 33x6 (33 clusters of six observations) sampling scheme to assess the prevalence of global acute malnutrition (GAM). Further, we explore the use of a 67x3 sequential sampling scheme for LQAS classification of GAM prevalence. Results indicate that, for independent clusters with moderate intracluster correlation for the GAM outcome, the three sampling designs maintain approximate validity for LQAS analysis. Sequential sampling can substantially reduce the average sample size that is required for data collection. The presence of intercluster correlation can impact dramatically the classification error that is associated with LQAS analysis.

  6. The Berlin Inventory of Gambling behavior - Screening (BIG-S): Validation using a clinical sample.

    Science.gov (United States)

    Wejbera, Martin; Müller, Kai W; Becker, Jan; Beutel, Manfred E

    2017-05-18

    Published diagnostic questionnaires for gambling disorder in German are either based on DSM-III criteria or focus on aspects other than life time prevalence. This study was designed to assess the usability of the DSM-IV criteria based Berlin Inventory of Gambling Behavior Screening tool in a clinical sample and adapt it to DSM-5 criteria. In a sample of 432 patients presenting for behavioral addiction assessment at the University Medical Center Mainz, we checked the screening tool's results against clinical diagnosis and compared a subsample of n=300 clinically diagnosed gambling disorder patients with a comparison group of n=132. The BIG-S produced a sensitivity of 99.7% and a specificity of 96.2%. The instrument's unidimensionality and the diagnostic improvements of DSM-5 criteria were verified by exploratory and confirmatory factor analysis as well as receiver operating characteristic analysis. The BIG-S is a reliable and valid screening tool for gambling disorder and demonstrated its concise and comprehensible operationalization of current DSM-5 criteria in a clinical setting.

  7. Criterion validity of a Wechsler-III Scale Short Form in a sample of brazilian elderly.

    Science.gov (United States)

    Banhato, Eliane Ferreira Carvalho; Leite, Isabel Cristina Gonçalves; Guedes, Danielle Viveiros; Chaoubah, Alfredo

    2010-01-01

    Although a normative process, changes in cognitive functioning vary among older adults. The differential diagnosis between normal and pathological aging must be made early using psychometrically adequate measures. To assess the evidence of criterion validity of a Short Form (SF) of the Wechsler-III Scale containing eight subtests (SF8) by determining its sensitivity, specificity, positive and negative predictive values and cut-off points for Brazilian elderly from different age groups. 168 individuals, aged 60 years or above, living in the community or in an institution, were assigned to case and control groups, and investigated according to age range. Measures included a sociodemographic questionnaire, the Mini-Mental State Examination (MMSE), Verbal Fluency Test, Clock-Drawing Test and the SF8. More than two thirds of the sample was women (73.8%), mean age was 74.5 years (SD=8.9), mean education was 6.2 years (SD=4.8) and 40.5% were widows/widowers. In the total sample, the best cut-off point for the SF8 was 142 while cut offs among individuals aged 60 to 69 years, 70 to 79 years, and more than 80 years were 160, 129 and 129, respectively. The results demonstrated the importance of different cut-off points for different age ranges. Sensitivity and specificity values of the SF8 were sufficiently high to warrant the use of the SF8 as an instrument to identify cognitive impairment in the elderly.

  8. The Dutch version of the Child Posttraumatic Cognitions Inventory: validation in a clinical sample and a school sample

    NARCIS (Netherlands)

    Diehle, Julia; de Roos, Carlijn; Meiser-Stedman, Richard; Boer, Frits; Lindauer, Ramón J. L.

    2015-01-01

    Background: With the inclusion of trauma-related cognitions in the DSM-5 criteria for posttraumatic stress disorder (PTSD), the assessment of these cognitions has become essential. Therefore, valid tools for the assessment of these cognitions are warranted. Objective: The current study aimed at

  9. Expert system verification and validation for nuclear power industry applications

    International Nuclear Information System (INIS)

    Naser, J.A.

    1990-01-01

    The potential for the use of expert systems in the nuclear power industry is widely recognized. The benefits of such systems include consistency of reasoning during off-normal situations when humans are under great stress, the reduction of times required to perform certain functions, the prevention of equipment failures through predictive diagnostics, and the retention of human expertise in performing specialized functions. The increased use of expert systems brings with it concerns about their reliability. Difficulties arising from software problems can affect plant safety, reliability, and availability. A joint project between EPRI and the US Nuclear Regulatory Commission is being initiated to develop a methodology for verification and validation of expert systems for nuclear power applications. This methodology will be tested on existing and developing expert systems. This effort will explore the applicability of conventional verification and validation methodologies to expert systems. The major area of concern will be certification of the knowledge base. This is expected to require new types of verification and validation techniques. A methodology for developing validation scenarios will also be studied

  10. Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection

    Science.gov (United States)

    Rosing, H.; Hillebrand, M. J. X.; Blesson, S.; Mengesha, B.; Diro, E.; Hailu, A.; Schellens, J. H. M.; Beijnen, J. H.

    2016-01-01

    To facilitate future pharmacokinetic studies of combination treatments against leishmaniasis in remote regions in which the disease is endemic, a simple cheap sampling method is required for miltefosine quantification. The aims of this study were to validate a liquid chromatography-tandem mass spectrometry method to quantify miltefosine in dried blood spot (DBS) samples and to validate its use with Ethiopian patients with visceral leishmaniasis (VL). Since hematocrit (Ht) levels are typically severely decreased in VL patients, returning to normal during treatment, the method was evaluated over a range of clinically relevant Ht values. Miltefosine was extracted from DBS samples using a simple method of pretreatment with methanol, resulting in >97% recovery. The method was validated over a calibration range of 10 to 2,000 ng/ml, and accuracy and precision were within ±11.2% and ≤7.0% (≤19.1% at the lower limit of quantification), respectively. The method was accurate and precise for blood spot volumes between 10 and 30 μl and for Ht levels of 20 to 35%, although a linear effect of Ht levels on miltefosine quantification was observed in the bioanalytical validation. DBS samples were stable for at least 162 days at 37°C. Clinical validation of the method using paired DBS and plasma samples from 16 VL patients showed a median observed DBS/plasma miltefosine concentration ratio of 0.99, with good correlation (Pearson's r = 0.946). Correcting for patient-specific Ht levels did not further improve the concordance between the sampling methods. This successfully validated method to quantify miltefosine in DBS samples was demonstrated to be a valid and practical alternative to venous blood sampling that can be applied in future miltefosine pharmacokinetic studies with leishmaniasis patients, without Ht correction. PMID:26787691

  11. Verification and Validation for Flight-Critical Systems (VVFCS)

    Science.gov (United States)

    Graves, Sharon S.; Jacobsen, Robert A.

    2010-01-01

    On March 31, 2009 a Request for Information (RFI) was issued by NASA s Aviation Safety Program to gather input on the subject of Verification and Validation (V & V) of Flight-Critical Systems. The responses were provided to NASA on or before April 24, 2009. The RFI asked for comments in three topic areas: Modeling and Validation of New Concepts for Vehicles and Operations; Verification of Complex Integrated and Distributed Systems; and Software Safety Assurance. There were a total of 34 responses to the RFI, representing a cross-section of academic (26%), small & large industry (47%) and government agency (27%).

  12. Demonstration/Validation of Incremental Sampling at Two Diverse Military Ranges and Development of an Incremental Sampling Tool

    Science.gov (United States)

    2010-06-01

    Sampling (MIS)? • Technique of combining many increments of soil from a number of points within exposure area • Developed by Enviro Stat (Trademarked...Demonstrating a reliable soil sampling strategy to accurately characterize contaminant concentrations in spatially extreme and heterogeneous...into a set of decision (exposure) units • One or several discrete or small- scale composite soil samples collected to represent each decision unit

  13. Fluid sample collection and distribution system. [qualitative analysis of aqueous samples from several points

    Science.gov (United States)

    Brooks, R. L. (Inventor)

    1979-01-01

    A multipoint fluid sample collection and distribution system is provided wherein the sample inputs are made through one or more of a number of sampling valves to a progressive cavity pump which is not susceptible to damage by large unfiltered particles. The pump output is through a filter unit that can provide a filtered multipoint sample. An unfiltered multipoint sample is also provided. An effluent sample can be taken and applied to a second progressive cavity pump for pumping to a filter unit that can provide one or more filtered effluent samples. The second pump can also provide an unfiltered effluent sample. Means are provided to periodically back flush each filter unit without shutting off the whole system.

  14. Validation of Temperament and Character Inventory (TCI in Iranian Sample: Normative Data

    Directory of Open Access Journals (Sweden)

    M Poor Naseh

    2005-05-01

    Full Text Available Background: This Study aimed to validate the temperament and character inventory (TCI in an Iranian sample of men and women with different ages. TCI contains subscales designed to measure seven different personality traits and characteristics. Materials and Methods: In the first step, subjects (n=1212 completed the questionnaire. In the second step, to examine the reliability of the questionnaire, 101 randomly chosen subjects were re-tested one to two months after the first test. Also, in order to examine the validity of the questionnaire, 100 subjects were interviewed by two psychologists using a checklist based on the Cloninger's biological theory of personality. The interviewers, who were blind to the subjects scores on the seven subscales, rated each subject for the seven traits and characteristics on a 10-point rating scale (from 1 to 10. Results & Conclusion: The results showed normative data for the subscales novelty seeking (NS, harm avoidance (HA, reward dependence (RD, persistence (Per, self directiveness (SD, cooperation (Co and self transcendence (ST for different gender and age classes. Correlations between the scores and ratings of the test and re-test revealed significant coefficients, confirming reliability for all subscales. A good internal consistency was found for each subscale. The results also showed no significant correlations higher than 0.40 among NS, HA, Per and RD; the temperament subscales were independent from each other. The only significant correlation, higher than 0.40, among the character subscales was between SD and Co. Applied and clinical implication of the present findings will be discussed.

  15. Empirical validation of the CRAFFT Abuse Screening Test in a Spanish sample.

    Science.gov (United States)

    Rial, Antonio; Kim-Harris, Sion; Knight, John R; Araujo, Manuel; Gómez, Patricia; Braña, Teresa; Varela, Jesús; Golpe, Sandra

    2018-01-15

    The CRAFFT Substance Abuse Screening Instrument, developed by the Center for Adolescents Substance Abuse Research (CeASAR) (Knight et al., 1999), is a screening tool for high-risk alcohol and drug risk consumption designed for use with adolescents. Since its publication it has been the subject of translations and validations in different countries, populations and contexts that have demonstrated its enormous potential. However, there is still no empirical validation study that would ensure its good psychometric performance in Spain. The aim of this paper is to develop an adapted version of the CRAFFT in Spanish and to analyze its psychometric properties in a sample of Spanish adolescents. For this purpose an individual interview was conducted on 312 adolescents aged between 12 and 18 years of age (M = 15.01; SD = 1.83) from the Galician community. The interview included a part of the Adolescent Diagnostic Interview (ADI) and the Problem Oriented Screening Instrument for Teenagers (POSIT). The results obtained, similar to those found in other countries, allow us to report that the Spanish version of the CRAFFT has a good psychometric behaviorproperties. It was found to have a satisfactory internal consistency with a Cronbach’s alpha value of .74. In terms of sensitivity and specificity, values of 74.4% and 96.4% respectively, were obtained and the area under the ROC curve was .946. The Spanish version of the CRAFFT is made available to researchers and professionals in the field of addictive behaviors, so that it can be used with the necessary psychometric guarantees.

  16. The Edinburgh Postnatal Depression Scale: translation and validation for a Greek sample.

    Science.gov (United States)

    Vivilaki, Victoria G; Dafermos, Vassilis; Kogevinas, Manolis; Bitsios, Panos; Lionis, Christos

    2009-09-09

    Edinburgh Postnatal Depression Scale (EPDS) is an important screening instrument that is used routinely with mothers during the postpartum period for early identification of postnatal depression. The purpose of this study was to validate the Greek version of EPDS along with sensitivity, specificity and predictive values. 120 mothers within 12 weeks postpartum were recruited from the perinatal care registers of the Maternity Departments of 4 Hospitals of Heraklion municipality, Greece. EPDS and Beck Depression Inventory-II (BDI-II) surveys were administered in random order to the mothers. Each mother was diagnosed with depression according to the validated Greek version of BDI-II. The psychometric measurements that were performed included: two independent samples t-tests, One-way analysis of variance (ANOVA), reliability coefficients, Explanatory factor analysis using a Varimax rotation and Principal Components Method. Confirmatory analysis -known as structural equation modelling- of principal components was conducted by LISREL (Linear Structural Relations). A receiver operating characteristic (ROC) analysis was carried out to evaluate the global functioning of the scale. 8 (6.7%) of the mothers were diagnosed with major postnatal depression, 14 (11.7%) with moderate and 38 (31.7%) with mild depression on the basis of BDI-II scores. The internal consistency of the EPDS Greek version -using Chronbach's alpha coefficient- was found 0.804 and that of Guttman split-half coefficient 0.742. Our findings confirm the multidimensionality of EPDS, demonstrating a two-factor structure which contained subscales reflecting depressive symptoms and anxiety. The Confirmatory Factor analysis demonstrated that the two factor model offered a very good fit to our data. The area under ROC curve AUC was found 0.7470 and the logistic estimate for the threshold score of 8/9 fitted the model sensitivity at 76.7% and model specificity at 68.3%. Our data confirm the validity of the Greek

  17. The Edinburgh Postnatal Depression Scale: translation and validation for a Greek sample

    Directory of Open Access Journals (Sweden)

    Kogevinas Manolis

    2009-09-01

    Full Text Available Abstract Background Edinburgh Postnatal Depression Scale (EPDS is an important screening instrument that is used routinely with mothers during the postpartum period for early identification of postnatal depression. The purpose of this study was to validate the Greek version of EPDS along with sensitivity, specificity and predictive values. Methods 120 mothers within 12 weeks postpartum were recruited from the perinatal care registers of the Maternity Departments of 4 Hospitals of Heraklion municipality, Greece. EPDS and Beck Depression Inventory-II (BDI-II surveys were administered in random order to the mothers. Each mother was diagnosed with depression according to the validated Greek version of BDI-II. The psychometric measurements that were performed included: two independent samples t-tests, One-way analysis of variance (ANOVA, reliability coefficients, Explanatory factor analysis using a Varimax rotation and Principal Components Method. Confirmatory analysis -known as structural equation modelling- of principal components was conducted by LISREL (Linear Structural Relations. A receiver operating characteristic (ROC analysis was carried out to evaluate the global functioning of the scale. Results 8 (6.7% of the mothers were diagnosed with major postnatal depression, 14 (11.7% with moderate and 38 (31.7% with mild depression on the basis of BDI-II scores. The internal consistency of the EPDS Greek version -using Chronbach's alpha coefficient- was found 0.804 and that of Guttman split-half coefficient 0.742. Our findings confirm the multidimensionality of EPDS, demonstrating a two-factor structure which contained subscales reflecting depressive symptoms and anxiety. The Confirmatory Factor analysis demonstrated that the two factor model offered a very good fit to our data. The area under ROC curve AUC was found 0.7470 and the logistic estimate for the threshold score of 8/9 fitted the model sensitivity at 76.7% and model specificity at 68

  18. Sample preparation system for microfluidic applications

    Science.gov (United States)

    Mosier, Bruce P [San Francisco, CA; Crocker, Robert W [Fremont, CA; Patel, Kamlesh D [Dublin, CA; Harnett, Cindy K [Livermore, CA

    2007-05-08

    An apparatus that couples automated injection with flow feedback to provide nanoliter accuracy in controlling microliter volumes. The apparatus comprises generally a source of hydraulic fluid pressure, a fluid isolator joined to the outlet of the hydraulic pressure source and a flow sensor to provide pressure-driven analyte metering. For operation generally and particularly in microfluidic systems the hydraulic pressure source is typically an electrokinetic (EK) pump that incorporates gasless electrodes. The apparatus is capable of metering sub-microliter volumes at flowrates of 1 100 .mu.L/min into microsystem load pressures of up to 1000 50 psi, respectively. Flowrates can be specified within 0.5 .mu.L/min and volumes as small as 80 nL can be metered.

  19. The Center for Epidemiologic Studies Depression Scale: Factor Validity and Reliability in a French Sample of Adolescents with Intellectual Disability

    Science.gov (United States)

    Maiano, Christophe; Morin, Alexandre J. S.; Begarie, Jerome

    2011-01-01

    The purpose of this study was to test the factor validity and reliability of the Center for Epidemiologic Studies Depression Scale (CES-D) within a sample of adolescents with mild to moderate Intellectual Disability (ID). A total sample of 189 adolescents (121 boys and 68 girls), aged between 12 and 18 years old, with mild to moderate ID were…

  20. Diagnosing Autism in Adults with Intellectual Disability: Validation of the DiBAS-R in an Independent Sample

    Science.gov (United States)

    Heinrich, Manuel; Böhm, Julia; Sappok, Tanja

    2018-01-01

    The study assessed the diagnostic validity of the diagnostic behavioral assessment for autism spectrum disorders-revised (DiBAS-R; 19-item screening scale based on ratings by caregivers) in a clinical sample of 381 adults with ID. Analysis revealed a sensitivity of 0.82 and a specificity of 0.67 in the overall sample (70.3% agreement). Sensitivity…

  1. Lagoa Real design. Description and evaluation of sampling system

    International Nuclear Information System (INIS)

    Hashizume, B.K.

    1982-10-01

    This report describes the samples preparation system of drilling from Lagoa Real Design, aiming obtainment representative fraction of the half from drilling outlier. The error of sampling + analysis and analytical accuracy was obtainment by delayed neutron analysis. (author)

  2. Extreme Environment Sampling System Deployment Mechanism, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Future Venus or Comet mission architectures may feature robotic sampling systems comprised of a Sampling Tool and Deployment Mechanism. Since 2005, Honeybee has been...

  3. Validation of NCSSHP for highly enriched uranium systems containing beryllium

    International Nuclear Information System (INIS)

    Krass, A.W.; Elliott, E.P.; Tollefson, D.A.

    1994-01-01

    This document describes the validation of KENO V.a using the 27-group ENDF/B-IV cross section library for highly enriched uranium and beryllium neutronic systems, and is in accordance with ANSI/ANS-8.1-1983(R1988) requirements for calculational methods. The validation has been performed on a Hewlett Packard 9000/Series 700 Workstation at the Oak Ridge Y-12 Plant Nuclear Criticality Safety Department using the Oak Ridge Y-12 Plant Nuclear Criticality Safety Software code package. Critical experiments from LA-2203, UCRL-4975, ORNL-2201, and ORNL/ENG-2 have been identified as having the constituents desired for this validation as well as sufficient experimental detail to allow accurate construction of KENO V.a calculational models. The results of these calculations establish the safety criteria to be employed in future calculational studies of these types of systems

  4. Verification and validation guidelines for high integrity systems. Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D. [SoHaR, Inc., Beverly Hills, CA (United States)

    1995-03-01

    High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities.

  5. Verification and validation guidelines for high integrity systems. Volume 1

    International Nuclear Information System (INIS)

    Hecht, H.; Hecht, M.; Dinsmore, G.; Hecht, S.; Tang, D.

    1995-03-01

    High integrity systems include all protective (safety and mitigation) systems for nuclear power plants, and also systems for which comparable reliability requirements exist in other fields, such as in the process industries, in air traffic control, and in patient monitoring and other medical systems. Verification aims at determining that each stage in the software development completely and correctly implements requirements that were established in a preceding phase, while validation determines that the overall performance of a computer system completely and correctly meets system requirements. Volume I of the report reviews existing classifications for high integrity systems and for the types of errors that may be encountered, and makes recommendations for verification and validation procedures, based on assumptions about the environment in which these procedures will be conducted. The final chapter of Volume I deals with a framework for standards in this field. Volume II contains appendices dealing with specific methodologies for system classification, for dependability evaluation, and for two software tools that can automate otherwise very labor intensive verification and validation activities

  6. Hanford Environmental Information System (HEIS). Volume 7: Sample and Data Tracking subject area

    International Nuclear Information System (INIS)

    1994-06-01

    The Hanford Environmental Information System (HEIS) Sample and Data Tracking subject area allows insertion of tracking information into a central repository where the data is immediately available for viewing. For example, a technical coordinator is able to view the current status of a particular sampling effort, from sample collection to data package validation dates. Four major types of data comprise the Sample and Data Tracking subject area: data about the mechanisms that groups a set of samples for a particular sampling effort; data about how constituents are grouped and assigned to a sample; data about when, where, and how samples are sent to a laboratory for analysis; and data bout the status of a sample's constituent analysis requirements, i.e., whether the analysis results have been returned from the laboratory

  7. Computer code ENDSAM for random sampling and validation of the resonance parameters covariance matrices of some major nuclear data libraries

    International Nuclear Information System (INIS)

    Plevnik, Lucijan; Žerovnik, Gašper

    2016-01-01

    Highlights: • Methods for random sampling of correlated parameters. • Link to open-source code for sampling of resonance parameters in ENDF-6 format. • Validation of the code on realistic and artificial data. • Validation of covariances in three major contemporary nuclear data libraries. - Abstract: Methods for random sampling of correlated parameters are presented. The methods are implemented for sampling of resonance parameters in ENDF-6 format and a link to the open-source code ENDSAM is given. The code has been validated on realistic data. Additionally, consistency of covariances of resonance parameters of three major contemporary nuclear data libraries (JEFF-3.2, ENDF/B-VII.1 and JENDL-4.0u2) has been checked.

  8. The Brief Negative Symptom Scale (BNSS): Independent validation in a large sample of Italian patients with schizophrenia.

    Science.gov (United States)

    Mucci, A; Galderisi, S; Merlotti, E; Rossi, A; Rocca, P; Bucci, P; Piegari, G; Chieffi, M; Vignapiano, A; Maj, M

    2015-07-01

    The Brief Negative Symptom Scale (BNSS) was developed to address the main limitations of the existing scales for the assessment of negative symptoms of schizophrenia. The initial validation of the scale by the group involved in its development demonstrated good convergent and discriminant validity, and a factor structure confirming the two domains of negative symptoms (reduced emotional/verbal expression and anhedonia/asociality/avolition). However, only relatively small samples of patients with schizophrenia were investigated. Further independent validation in large clinical samples might be instrumental to the broad diffusion of the scale in clinical research. The present study aimed to examine the BNSS inter-rater reliability, convergent/discriminant validity and factor structure in a large Italian sample of outpatients with schizophrenia. Our results confirmed the excellent inter-rater reliability of the BNSS (the intraclass correlation coefficient ranged from 0.81 to 0.98 for individual items and was 0.98 for the total score). The convergent validity measures had r values from 0.62 to 0.77, while the divergent validity measures had r values from 0.20 to 0.28 in the main sample (n=912) and in a subsample without clinically significant levels of depression and extrapyramidal symptoms (n=496). The BNSS factor structure was supported in both groups. The study confirms that the BNSS is a promising measure for quantifying negative symptoms of schizophrenia in large multicenter clinical studies. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  9. Classifying snakebite in South Africa: Validating a scoring system ...

    African Journals Online (AJOL)

    Factors predictive of ATI and the optimal cut-off score for predicting an ATI were identified. These factors were then used to develop a standard scoring system. The score was then tested prospectively for accuracy in a new validation cohort consisting of 100 patients admitted for snakebite to our unit from 1 December 2014 to ...

  10. Pre-crash system validation with PRESCAN and VEHIL

    NARCIS (Netherlands)

    Gietelink, O.J.; Verburg, D.J.; Labibes, K.; Oostendorp, A.F.

    2004-01-01

    This paper presents the tools for design and validation of Pre-Crash Systems: the software tool PRE-crash SCenario ANalyzer (PRESCAN) and the VEhicle-Hardware-In-the-Loop (VEHIL) facility. PRESCAN allows to investigate a pre-crash scenario in simulation. This scenario can then be compared with tests

  11. Design and validation of advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.

    2007-01-01

    This thesis presents new tools and methods for the design and validation of advanced driver assistance systems (ADASs). ADASs aim to improve driving comfort and traffic safety by assisting the driver in recognizing and reacting to potentially dangerous traffic situations. A major challenge in

  12. Traffic modelling validation of advanced driver assistance systems

    NARCIS (Netherlands)

    Tongeren, R. van; Gietelink, O.J.; Schutter, B. de; Verhaegen, M.

    2007-01-01

    This paper presents a microscopic traffic model for the validation of advanced driver assistance systems. This model describes single-lane traffic and is calibrated with data from a field operational test. To illustrate the use of the model, a Monte Carlo simulation of single-lane traffic scenarios

  13. Formal validation of supervisory energy management systems for microgrids

    DEFF Research Database (Denmark)

    Sugumar, Gayathri; Selvamuthukumaran, R.; Dragicevic, T.

    2017-01-01

    techniques are available in the literature to monitor and control the energy flows among distributed RES in MGs, formal verification of those techniques was not proposed yet. The emphasis of this paper is to design and validate energy management system for a MG which consists of a solar photovoltaic (PV...

  14. An initial validation of the Virtual Reality Paced Auditory Serial Addition Test in a college sample.

    Science.gov (United States)

    Parsons, Thomas D; Courtney, Christopher G

    2014-01-30

    Numerous studies have demonstrated that the Paced Auditory Serial Addition Test (PASAT) has utility for the detection of cognitive processing deficits. While the PASAT has demonstrated high levels of internal consistency and test-retest reliability, administration of the PASAT has been known to create undue anxiety and frustration in participants. As a result, degradation of performance may be found on the PASAT. The difficult nature of the PASAT may subsequently decrease the probability of their return for follow up testing. This study is a preliminary attempt at assessing the potential of a PASAT embedded in a virtual reality environment. The Virtual Reality PASAT (VR-PASAT) was compared with a paper-and-pencil version of the PASAT as well as other standardized neuropsychological measures. The two modalities of the PASAT were conducted with a sample of 50 healthy university students, between the ages of 19 and 34 years. Equivalent distributions were found for age, gender, education, and computer familiarity. Moderate relationships were found between VR-PASAT and other putative attentional processing measures. The VR-PASAT was unrelated to indices of learning, memory, or visuospatial processing. Comparison of the VR-PASAT with the traditional paper-and-pencil PASAT indicated that both versions require the examinee to sustain attention at an increasingly demanding, externally determined rate. Results offer preliminary support for the construct validity (in a college sample) of the VR-PASAT as an attentional processing measure and suggest that this task may provide some unique information not tapped by traditional attentional processing tasks. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Criterion validity of a Wechsler-III scale short form in a sample of Brazilian Elderly

    Directory of Open Access Journals (Sweden)

    Eliane Ferreira Carvalho Banhato

    Full Text Available Abstract Although a normative process, changes in cognitive functioning vary among older adults. The differential diagnosis between normal and pathological aging must be made early using psychometrically adequate measures. Objectives: To assess the evidence of criterion validity of a Short Form (SF of the Wechsler-III Scale containing eight subtests (SF8 by determining its sensitivity, specificity, positive and negative predictive values and cut-off points for Brazilian elderly from different age groups. Methods: 168 individuals, aged 60 years or above, living in the community or in an institution, were assigned to case and control groups, and investigated according to age range. Measures included a sociodemographic questionnaire, the Mini-Mental State Examination (MMSE, Verbal Fluency Test, Clock-Drawing Test and the SF8. Results: More than two thirds of the sample was women (73.8%, mean age was 74.5 years (SD=8.9, mean education was 6.2 years (SD=4.8 and 40.5% were widows/widowers. In the total sample, the best cut-off point for the SF8 was 142 while cut offs among individuals aged 60 to 69 years, 70 to 79 years, and more than 80 years were 160, 129 and 129, respectively. Conclusions: The results demonstrated the importance of different cut-off points for different age ranges. Sensitivity and specificity values of the SF8 were sufficiently high to warrant the use of the SF8 as an instrument to identify cognitive impairment in the elderly.

  16. An attempt to validate serum and plasma as sample matrices for analyses of polychlorobiphenylols

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, J.; Bergman, Aa. [Stockholm Univ. (Sweden). Dept. of Environmental Chemistry; Bignert, A. [Museum of Natural History (Sweden)

    2004-09-15

    Polychlorinated biphenyls (PCBs) form hydroxylated metabolites (OH-PCBs), as reported both from wildlife and from experimental animal studies already in the early 1970s'. However, the interest increased in OH-PCBs from the mid 1990s' depending on the discovery that some OHPCB congeners are strongly retained in the blood of birds, fish and mammals, including humans. The interest is linked to the fact that OH-PCBs is strongly, but reversibly, bound to the blood protein transthyretin (TTR). It is reasonable to believe that the strong TTR binding may have toxicological impact, probably related to endocrine type effects. Importantly, OH-PCBs are present in blood at far higher concentrations than in any other compartment in the body, which is dependent on the physico-chemical characteristics of the phenols. Analyses of OH-PCBs have thus been concentrated to whole blood, plasma or serum. Still there is no comparison between the three sample types even though it is clear that whole blood is not optimal due to the large proportion of haemoglobin in the sample that make the clean up more difficult than if plasma or serum is selected for analysis. In the present study we have addressed two questions: First we have looked at any potential differences in the analytical results of OH-PCBs when using serum and plasma for extraction and clean up; Second, the serum and plasma applied in the validation has been unfrozen, frozen (at -20 C) for two months and frozen for twenty months, respectively.

  17. Validation of the Goal Content for Exercise Questionnaire (GCEQ for a sample of elderly Portuguese people

    Directory of Open Access Journals (Sweden)

    Raul Antunes

    2017-06-01

    Full Text Available According Sebire, Standage and Vansteenkiste (2008, goals contents (motives are the major drivers of behavior, giving rise to the goal content theory, which is in the basis of Goal Content for Exercise Questionnaire (GCEQ: Sebire et al., 2008 development. So, the main goal of present study was to conduct the validation of GCEQ for a sample of Portuguese elderly (n = 311, with equal or higher ages than 60 years old (M = 68.53; DP = 6.69. The main results show us that CGEQ measurement model (5 factors, 20 items only present adequate fit to data after the elimination of 3 items: S-Bχ²=219.9, df=109, p=.001, SRMR=.049, TLI=.916, CFI=.934, RMSEA=.057, RMSEA 90% CI=.046-.068, PCFI=.747. Besides that, the 5 factors show us acceptable values of composite reliability: between .76 and .88. Those findings allow us to conclude that GCEQ with 5 factors and 17 items can be used to measure goal content in a population of elderly Portuguese people in physical activity domain.

  18. Bayley-III: Cultural differences and language scale validity in a Danish sample.

    Science.gov (United States)

    Krogh, Marianne T; Vaever, Mette S

    2016-12-01

    The purpose of this study was to investigate cultural differences between Danish and American children at 2 and 3 years as measured with the developmental test Bayley-III, and to investigate the Bayley-III Language Scale validity. The Danish children (N = 43) were tested with the Bayley-III and their parents completed an additional language questionnaire (the MacArthur-Bates CDI). Results showed that scores from the Danish children did not differ significantly from the American norms on the Cognitive or Motor Scale, but the Danish sample scored significantly higher on the Language Scale. A comparison of the Bayley-III Language subtests with the CDI showed that the two measures correlated significantly, but the percentile score from the CDI was significantly higher than the percentile score from the Bayley-III Language subtests. This could be because the two instruments measure slightly different areas of language development, or because the Bayley-III overestimates language development in Danish children. However, due to the limitations of the current study, further research is needed to clarify this issue. © 2016 Scandinavian Psychological Associations and John Wiley & Sons Ltd.

  19. Validity of the reduced-sample insulin modified frequently-sampled intravenous glucose tolerance test using the nonlinear regression approach.

    Science.gov (United States)

    Sumner, Anne E; Luercio, Marcella F; Frempong, Barbara A; Ricks, Madia; Sen, Sabyasachi; Kushner, Harvey; Tulloch-Reid, Marshall K

    2009-02-01

    The disposition index, the product of the insulin sensitivity index (S(I)) and the acute insulin response to glucose, is linked in African Americans to chromosome 11q. This link was determined with S(I) calculated with the nonlinear regression approach to the minimal model and data from the reduced-sample insulin-modified frequently-sampled intravenous glucose tolerance test (Reduced-Sample-IM-FSIGT). However, the application of the nonlinear regression approach to calculate S(I) using data from the Reduced-Sample-IM-FSIGT has been challenged as being not only inaccurate but also having a high failure rate in insulin-resistant subjects. Our goal was to determine the accuracy and failure rate of the Reduced-Sample-IM-FSIGT using the nonlinear regression approach to the minimal model. With S(I) from the Full-Sample-IM-FSIGT considered the standard and using the nonlinear regression approach to the minimal model, we compared the agreement between S(I) from the Full- and Reduced-Sample-IM-FSIGT protocols. One hundred African Americans (body mass index, 31.3 +/- 7.6 kg/m(2) [mean +/- SD]; range, 19.0-56.9 kg/m(2)) had FSIGTs. Glucose (0.3 g/kg) was given at baseline. Insulin was infused from 20 to 25 minutes (total insulin dose, 0.02 U/kg). For the Full-Sample-IM-FSIGT, S(I) was calculated based on the glucose and insulin samples taken at -1, 1, 2, 3, 4, 5, 6, 7, 8,10, 12, 14, 16, 19, 22, 23, 24, 25, 27, 30, 40, 50, 60, 70, 80, 90, 100, 120, 150, and 180 minutes. For the Reduced-Sample-FSIGT, S(I) was calculated based on the time points that appear in bold. Agreement was determined by Spearman correlation, concordance, and the Bland-Altman method. In addition, for both protocols, the population was divided into tertiles of S(I). Insulin resistance was defined by the lowest tertile of S(I) from the Full-Sample-IM-FSIGT. The distribution of subjects across tertiles was compared by rank order and kappa statistic. We found that the rate of failure of resolution of S(I) by

  20. Gravitational radiation quadrupole formula is valid for gravitationally interacting systems

    International Nuclear Information System (INIS)

    Walker, M.; Will, C.M.

    1980-01-01

    An argument is presented for the validity of the quadrupole formula for gravitational radiation energy loss in the far field of nearly Newtonian (e.g., binary stellar) systems. This argument differs from earlier ones in that it determines beforehand the formal accuracy of approximation required to describe gravitationally self-interacting systems, uses the corresponding approximate equation of motion explicitly, and evaluate the appropriate asymptotic quantities by matching along the correct space-time light cones

  1. Validation of a new classification system for interprosthetic femoral fractures.

    Science.gov (United States)

    Pires, Robinson Esteves Santos; Silveira, Marcelo Peixoto Sena; Resende, Alessandra Regina da Silva; Junior, Egidio Oliveira Santana; Campos, Tulio Vinicius Oliveira; Santos, Leandro Emilio Nascimento; Balbachevsky, Daniel; Andrade, Marco Antônio Percope de

    2017-07-01

    Interprosthetic femoral fracture (IFF) incidence is gradually increasing as the population is progressively ageing. However, treatment remains challenging due to several contributing factors, such as poor bone quality, patient comorbidities, small interprosthetic fragment, and prostheses instability. An effective and specific classification system is essential to optimize treatment management, therefore diminishing complication rates. This study aims to validate a previously described classification system for interprosthetic femoral fractures. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Experimental performance evaluation of two stack sampling systems in a plutonium facility

    International Nuclear Information System (INIS)

    Glissmeyer, J.A.

    1992-04-01

    The evaluation of two routine stack sampling systems at the Z-Plant plutonium facility operated by Rockwell International for USERDA is part of a larger study, sponsored by Rockwell and conducted by Battelle, Pacific Northwest Laboratories, of gaseous effluent sampling systems. The gaseous effluent sampling systems evaluated are located at the main plant ventilation stack (291-Z-1) and at a vessel vent stack (296-Z-3). A preliminary report, which was a paper study issued in April 1976, identified many deficiencies in the existing sampling systems and made recommendations for corrective action. The objectives of this experimental evaluation of those sampling systems were as follows: Characterize the radioactive aerosols in the stack effluents; Develop a tracer aerosol technique for validating particulate effluent sampling system performance; Evaluate the performance of the existing routine sampling systems and their compliance with the sponsor's criteria; and Recommend corrective action where required. The tracer aerosol approach to sampler evaluation was chosen because the low concentrations of radioactive particulates in the effluents would otherwise require much longer sampling times and thus more time to complete this evaluation. The following report describes the sampling systems that are the subject of this study and then details the experiments performed. The results are then presented and discussed. Much of the raw and finished data are included in the appendices

  3. The Metacognitive Anger Processing (MAP) Scale - Validation in a Mixed Clinical and a Forensic In-Patient Sample

    DEFF Research Database (Denmark)

    Moeller, Stine Bjerrum; Bech, Per

    2018-01-01

    BACKGROUND: The metacognitive approach by Wells and colleagues has gained empirical support with a broad range of symptoms. The Metacognitive Anger Processing (MAP) scale was developed to provide a metacognitive measure on anger (Moeller, 2016). In the preliminary validation, three components were...... identified (positive beliefs, negative beliefs and rumination) to be positively correlated with the anger. AIMS: To validate the MAP in a sample of mixed clinical patients (n = 88) and a sample of male forensic patients (n = 54). METHOD: The MAP was administered together with measures of metacognition, anger......, rumination, anxiety and depressive symptoms. RESULTS: The MAP showed acceptable scalability and excellent reliability. Convergent validity was evidenced using the general metacognitive measure (MCQ-30), and concurrent validity was supported using two different anger measures (STAXI-2 and NAS). CONCLUSIONS...

  4. Validation of safeguards monitoring systems and their simulations

    International Nuclear Information System (INIS)

    Standley, V.; Boeck, H.; Villa, M.

    2001-01-01

    Research is underway at the Atominstitut in Vienna Austria where the objective is to design and validate quantitatively a safeguards monitoring system (SMS) and its simulation. The work is novel because the simulation is also used as the basis for automated evaluation of SMS data. Preliminary results indicate that video and radiation data can be automatically interpreted using this approach. Application of the technique promises that an investment in a simulation supports directly the safeguards objective, which is to catch diversion of nuclear material. Consequently, it is easier for a safeguards agency to also realize other benefits associated with simulation-based acquisition, in addition to having a quantitative method for validation

  5. Automatic remote sampling and delivery system incorporating decontamination and disposal of sample bottles

    International Nuclear Information System (INIS)

    Savarkar, V.K.; Mishra, A.K.; Bajpai, D.D.; Nair, M.K.T.

    1990-01-01

    The present generation of reprocessing plants have sampling and delivery systems that have to be operated manually with its associated problems. The complete automation and remotisation of sampling system has hence been considered to reduce manual intervention and personnel exposure. As a part of this scheme an attempt to automate and remotise various steps in sampling system has been made. This paper discusses in detail the development work carried out in this area as well as the tests conducted to incorporate the same in the existing plants. (author). 3 figs

  6. Validation Test Results for Orthogonal Probe Eddy Current Thruster Inspection System

    Science.gov (United States)

    Wincheski, Russell A.

    2007-01-01

    Recent nondestructive evaluation efforts within NASA have focused on an inspection system for the detection of intergranular cracking originating in the relief radius of Primary Reaction Control System (PCRS) Thrusters. Of particular concern is deep cracking in this area which could lead to combustion leakage in the event of through wall cracking from the relief radius into an acoustic cavity of the combustion chamber. In order to reliably detect such defects while ensuring minimal false positives during inspection, the Orthogonal Probe Eddy Current (OPEC) system has been developed and an extensive validation study performed. This report describes the validation procedure, sample set, and inspection results as well as comparing validation flaws with the response from naturally occuring damage.

  7. Analysis format and evaluation methods for effluent particle sampling systems in nuclear facilities

    International Nuclear Information System (INIS)

    Schwendiman, L.C.; Glissmeyer, J.A.

    1976-06-01

    Airborne effluent sampling systems for nuclear facilities are frequently designed, installed, and operated without a systematic approach which discloses and takes into account all the circumstances and conditions which would affect the validity and adequacy of the sample. Without a comprehensive check list or something similar, the designer of the system may not be given the important information needed to provide a good design. In like manner, an already operating system may be better appraised. Furthermore, the discipline of a more formal approach may compel the one who will use the system to make sure he knows what he wants and can thus give the designer the needed information. An important consideration is the criteria to be applied to the samples to be taken. This analysis format consists of a listing of questions and statements calling forth the necessary information required to analyze a sampling system. With this information developed, one can proceed with an evaluation, the methodology of which is also discussed in the paper. Errors in probe placement, failure to sample at the proper rate, delivery line losses, and others are evaluated using mathematical models and empirically derived relationships. Experimental methods are also described for demonstrating that quality sampling will be achieved. The experiments include using a temporary, simple, but optimal sample collection system to evaluate the more complex systems. The use of tracer particles injected in the stream is also discussed. The samples obtained with the existing system are compared with those obtained by the temporary, optimal system

  8. A new dataset validation system for the Planetary Science Archive

    Science.gov (United States)

    Manaud, N.; Zender, J.; Heather, D.; Martinez, S.

    2007-08-01

    The Planetary Science Archive is the official archive for the Mars Express mission. It has received its first data by the end of 2004. These data are delivered by the PI teams to the PSA team as datasets, which are formatted conform to the Planetary Data System (PDS). The PI teams are responsible for analyzing and calibrating the instrument data as well as the production of reduced and calibrated data. They are also responsible of the scientific validation of these data. ESA is responsible of the long-term data archiving and distribution to the scientific community and must ensure, in this regard, that all archived products meet quality. To do so, an archive peer-review is used to control the quality of the Mars Express science data archiving process. However a full validation of its content is missing. An independent review board recently recommended that the completeness of the archive as well as the consistency of the delivered data should be validated following well-defined procedures. A new validation software tool is being developed to complete the overall data quality control system functionality. This new tool aims to improve the quality of data and services provided to the scientific community through the PSA, and shall allow to track anomalies in and to control the completeness of datasets. It shall ensure that the PSA end-users: (1) can rely on the result of their queries, (2) will get data products that are suitable for scientific analysis, (3) can find all science data acquired during a mission. We defined dataset validation as the verification and assessment process to check the dataset content against pre-defined top-level criteria, which represent the general characteristics of good quality datasets. The dataset content that is checked includes the data and all types of information that are essential in the process of deriving scientific results and those interfacing with the PSA database. The validation software tool is a multi-mission tool that

  9. Developmental validation of a Nextera XT mitogenome Illumina MiSeq sequencing method for high-quality samples.

    Science.gov (United States)

    Peck, Michelle A; Sturk-Andreaggi, Kimberly; Thomas, Jacqueline T; Oliver, Robert S; Barritt-Ross, Suzanne; Marshall, Charla

    2018-05-01

    Generating mitochondrial genome (mitogenome) data from reference samples in a rapid and efficient manner is critical to harnessing the greater power of discrimination of the entire mitochondrial DNA (mtDNA) marker. The method of long-range target enrichment, Nextera XT library preparation, and Illumina sequencing on the MiSeq is a well-established technique for generating mitogenome data from high-quality samples. To this end, a validation was conducted for this mitogenome method processing up to 24 samples simultaneously along with analysis in the CLC Genomics Workbench and utilizing the AQME (AFDIL-QIAGEN mtDNA Expert) tool to generate forensic profiles. This validation followed the Federal Bureau of Investigation's Quality Assurance Standards (QAS) for forensic DNA testing laboratories and the Scientific Working Group on DNA Analysis Methods (SWGDAM) validation guidelines. The evaluation of control DNA, non-probative samples, blank controls, mixtures, and nonhuman samples demonstrated the validity of this method. Specifically, the sensitivity was established at ≥25 pg of nuclear DNA input for accurate mitogenome profile generation. Unreproducible low-level variants were observed in samples with low amplicon yields. Further, variant quality was shown to be a useful metric for identifying sequencing error and crosstalk. Success of this method was demonstrated with a variety of reference sample substrates and extract types. These studies further demonstrate the advantages of using NGS techniques by highlighting the quantitative nature of heteroplasmy detection. The results presented herein from more than 175 samples processed in ten sequencing runs, show this mitogenome sequencing method and analysis strategy to be valid for the generation of reference data. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. ANL small-sample calorimeter system design and operation

    International Nuclear Information System (INIS)

    Roche, C.T.; Perry, R.B.; Lewis, R.N.; Jung, E.A.; Haumann, J.R.

    1978-07-01

    The Small-Sample Calorimetric System is a portable instrument designed to measure the thermal power produced by radioactive decay of plutonium-containing fuels. The small-sample calorimeter is capable of measuring samples producing power up to 32 milliwatts at a rate of one sample every 20 min. The instrument is contained in two packages: a data-acquisition module consisting of a microprocessor with an 8K-byte nonvolatile memory, and a measurement module consisting of the calorimeter and a sample preheater. The total weight of the system is 18 kg

  11. Two-Stage Variable Sample-Rate Conversion System

    Science.gov (United States)

    Tkacenko, Andre

    2009-01-01

    A two-stage variable sample-rate conversion (SRC) system has been pro posed as part of a digital signal-processing system in a digital com munication radio receiver that utilizes a variety of data rates. The proposed system would be used as an interface between (1) an analog- todigital converter used in the front end of the receiver to sample an intermediatefrequency signal at a fixed input rate and (2) digita lly implemented tracking loops in subsequent stages that operate at v arious sample rates that are generally lower than the input sample r ate. This Two-Stage System would be capable of converting from an input sample rate to a desired lower output sample rate that could be var iable and not necessarily a rational fraction of the input rate.

  12. A THz Tomography System for Arbitrarily Shaped Samples

    Science.gov (United States)

    Stübling, E.; Bauckhage, Y.; Jelli, E.; Fischer, B.; Globisch, B.; Schell, M.; Heinrich, A.; Balzer, J. C.; Koch, M.

    2017-10-01

    We combine a THz time-domain spectroscopy system with a robotic arm. With this scheme, the THz emitter and receiver can be positioned perpendicular and at defined distance to the sample surface. Our system allows the acquisition of reflection THz tomographic images of samples with an arbitrarily shaped surface.

  13. The Trait Emotional Intelligence Questionnaire: Internal Structure, Convergent, Criterion, and Incremental Validity in an Italian Sample

    Science.gov (United States)

    Andrei, Federica; Smith, Martin M.; Surcinelli, Paola; Baldaro, Bruno; Saklofske, Donald H.

    2016-01-01

    This study investigated the structure and validity of the Italian translation of the Trait Emotional Intelligence Questionnaire. Data were self-reported from 227 participants. Confirmatory factor analysis supported the four-factor structure of the scale. Hierarchical regressions also demonstrated its incremental validity beyond demographics, the…

  14. Establishing the Validity of the Personality Assessment Inventory Drug and Alcohol Scales in a Corrections Sample

    Science.gov (United States)

    Patry, Marc W.; Magaletta, Philip R.; Diamond, Pamela M.; Weinman, Beth A.

    2011-01-01

    Although not originally designed for implementation in correctional settings, researchers and clinicians have begun to use the Personality Assessment Inventory (PAI) to assess offenders. A relatively small number of studies have made attempts to validate the alcohol and drug abuse scales of the PAI, and only a very few studies have validated those…

  15. Cross-Validation of Levenson's Psychopathy Scale in a Sample of Federal Female Inmates

    Science.gov (United States)

    Brinkley, Chad A.; Diamond, Pamela M.; Magaletta, Philip R.; Heigel, Caron P.

    2008-01-01

    Levenson, Kiehl, and Fitzpatrick's Self-Report Psychopathy Scale (LSRPS) is evaluated to determine the factor structure and concurrent validity of the instrument among 430 federal female inmates. Confirmatory factor analysis fails to validate the expected 2-factor structure. Subsequent exploratory factor analysis reveals a 3-factor structure…

  16. Data Validation Package - April and July 2015 Groundwater and Surface Water Sampling at the Gunnison, Colorado, Processing Site

    Energy Technology Data Exchange (ETDEWEB)

    Linard, Joshua [Dept. of Energy (DOE), Washington, DC (United States). Office of Legacy Management; Campbell, Sam [Navarro Research and Engineering, Inc., Oak Ridge, TN (United States)

    2016-02-01

    This event included annual sampling of groundwater and surface water locations at the Gunnison, Colorado, Processing Site. Sampling and analyses were conducted as specified in Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites. Samples were collected from 28 monitoring wells, three domestic wells, and six surface locations in April at the processing site as specified in the 2010 Ground Water Compliance Action Plan for the Gunnison, Colorado, Processing Site. Domestic wells 0476 and 0477 were sampled in July because the homes were unoccupied in April, and the wells were not in use. Duplicate samples were collected from locations 0113, 0248, and 0477. One equipment blank was collected during this sampling event. Water levels were measured at all monitoring wells that were sampled. No issues were identified during the data validation process that requires additional action or follow-up.

  17. Assessment of bachelor's theses in a nursing degree with a rubrics system: Development and validation study.

    Science.gov (United States)

    González-Chordá, Víctor M; Mena-Tudela, Desirée; Salas-Medina, Pablo; Cervera-Gasch, Agueda; Orts-Cortés, Isabel; Maciá-Soler, Loreto

    2016-02-01

    Writing a bachelor thesis (BT) is the last step to obtain a nursing degree. In order to perform an effective assessment of a nursing BT, certain reliable and valid tools are required. To develop and validate a 3-rubric system (drafting process, dissertation, and viva) to assess final year nursing students' BT. A multi-disciplinary study of content validity and psychometric properties. The study was carried out between December 2014 and July 2015. Nursing Degree at Universitat Jaume I. Spain. Eleven experts (9 nursing professors and 2 education professors from 6 different universities) took part in the development and content validity stages. Fifty-two theses presented during the 2014-2015 academic year were included by consecutive sampling of cases in order to study the psychometric properties. First, a group of experts was created to validate the content of the assessment system based on three rubrics (drafting process, dissertation, and viva). Subsequently, a reliability and validity study of the rubrics was carried out on the 52 theses presented during the 2014-2015 academic year. The BT drafting process rubric has 8 criteria (S-CVI=0.93; α=0.837; ICC=0.614), the dissertation rubric has 7 criteria (S-CVI=0.9; α=0.893; ICC=0.74), and the viva rubric has 4 criteria (S-CVI=0.86; α=8.16; ICC=0.895). A nursing BT assessment system based on three rubrics (drafting process, dissertation, and viva) has been validated. This system may be transferred to other nursing degrees or degrees from other academic areas. It is necessary to continue with the validation process taking into account factors that may affect the results obtained. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Validating the JobFit system functional assessment method

    Energy Technology Data Exchange (ETDEWEB)

    Jenny Legge; Robin Burgess-Limerick

    2007-05-15

    Workplace injuries are costing the Australian coal mining industry and its communities $410 Million a year. This ACARP study aims to meet those demands by developing a safe, reliable and valid pre-employment functional assessment tool. All JobFit System Pre-Employment Functional Assessments (PEFAs) consist of a musculoskeletal screen, balance test, aerobic fitness test and job-specific postural tolerances and material handling tasks. The results of each component are compared to the applicant's job demands and an overall PEFA score between 1 and 4 is given with 1 being the better score. The reliability study and validity study were conducted concurrently. The reliability study examined test-retest, intra-tester and inter-tester reliability of the JobFit System Functional Assessment Method. Overall, good to excellent reliability was found, which was sufficient to be used for comparison with injury data for determining the validity of the assessment. The overall assessment score and material handling tasks had the greatest reliability. The validity study compared the assessment results of 336 records from a Queensland underground and open cut coal mine with their injury records. A predictive relationship was found between PEFA score and the risk of a back/trunk/shoulder injury from manual handling. An association was also found between PEFA score of 1 and increased length of employment. Lower aerobic fitness test results had an inverse relationship with injury rates. The study found that underground workers, regardless of PEFA score, were more likely to have an injury when compared to other departments. No relationship was found between age and risk of injury. These results confirm the validity of the JobFit System Functional Assessment method.

  19. Noncontact inspection laser system for characterization of piezoelectric samples

    International Nuclear Information System (INIS)

    Jimenez, F.J.; Frutos, J. de

    2004-01-01

    In this work measurements on a piezoelectric sample in dynamic behavior were taken, in particular, around the frequencies of resonance for the sample where the nonlineal effects are accentuated. Dimension changes in the sample need to be studied as that will allow a more reliable characterization of the piezoelectric samples. The goal of this research is to develop an inspection system able to obtain measurements, using a noncontact laser displacement transducer, also able to visualize, in three-dimensional graphic environment, the displacement that takes place in a piezoelectric sample surface. In resonant mode, the vibration mode of the sample is visualized

  20. Development and validation of reversed-phase high performance liquid chromatographic method for analysis of cephradine in human plasma samples

    International Nuclear Information System (INIS)

    Ahmad, M.; Usman, M.; Madni, A.; Akhtar, N.; Khalid, N.; Asghar, W.

    2010-01-01

    An HPLC method with high precision, accuracy and selectivity was developed and validated for the assessment of cephradine in human plasma samples. The extraction procedure was simple and accurate with single step followed by direct injection of sample into HPLC system. The extracted cephradine in spiked human plasma was separated and quantitated using reversed phase C/sub 18/ column and UV detection wavelength of 254 nm. The optimized mobile phase of new composition of 0.05 M potassium dihydrogen phosphate (pH 3.4)-acetonitrile (88: 12) was pumped at an optimum flow rate of 1 mL.min/sup 1/. The method resulted linearity in the concentration range 0.15- 20 micro g mL/sup -1/. The limit of detection (LOD) and limit of quantification (LOQ) were 0.05 and 0.150 Microg.mL/sup -1/, respectively. The accuracy of method was 98.68 %. This method can 1>e applied for bioequivalence studies and therapeutic drug monitoring as well as for the routine analysis of cephradine. (author)

  1. VALIDATION OF THE SERVICEABILITY OF THE MANUFACTURING SYSTEM USING SIMULATION

    Directory of Open Access Journals (Sweden)

    LAZÁR, Ivan

    2012-12-01

    Full Text Available This article discusses the creation and use of known algorithms in production that uses a flow-shop system to monitor and verify its operability. It also describes the input data, which must be further opportunities for decision entered into the system. In the next section are described in detail the different parts of this procedure. Than it describes the sequential problems that are not yet at a practical level, few addressed, but thus methods shorten the processing time. The conclusion focuses on the validation of the serviceability of the manufacturing system using knowledge mentioned and their embedding and verification by simulation.

  2. Development of an expert system for signal validation

    International Nuclear Information System (INIS)

    Qualls, A.L.; Uhrig, R.E.; Upadhyaya, B.R.

    1988-01-01

    Diagnosis of malfunctions in power plants has traditionally been in the domain of the process operator, who relies on training, experience, and reasoning ability to diagnose faults. The authors describe a method of signal validation using expert system technology, which detects possible anomalies in an instrument channel's output, similar to the procedure used by an operator. The system can be used to scan quickly over an array of sensor outputs and flag those that are observed to have possible anomalies. This system, when implemented in an operating power plant, could be used for continuous, on-line instrument anomaly detection with a minimum of computational effort

  3. VEHIL: a test facility for validation of fault management systems for advanced driver assistance systems

    NARCIS (Netherlands)

    Gietelink, O.J.; Ploeg, J.; Schutter, de B.; Verhaegen, M.H.

    2004-01-01

    We present a methodological approach for the validation of fault management systems for Advanced Driver Assistance Systems (ADAS). For the validation process the unique VEHIL facility, developed by TNO Automotive and currently situated in Helmond, The Netherlands, is applied. The VEHIL facility

  4. Validation of the French version of the yale food addiction scale: an examination of its factor structure, reliability, and construct validity in a nonclinical sample.

    Science.gov (United States)

    Brunault, Paul; Ballon, Nicolas; Gaillard, Philippe; Réveillère, Christian; Courtois, Robert

    2014-05-01

    The concept of food addiction has recently been proposed by applying the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, criteria for substance dependence to eating behaviour. Food addiction has received increased attention given that it may play a role in binge eating, eating disorders, and the recent increase in obesity prevalence. Currently, there is no psychometrically sound tool for assessing food addiction in French. Our study aimed to test the psychometric properties of a French version of the Yale Food Addiction Scale (YFAS) by establishing its factor structure and construct validity in a nonclinical population. A total of 553 participants were assessed for food addiction (French version of the YFAS) and binge eating behaviour (Bulimic Investigatory Test Edinburgh and Binge Eating Scale). We tested the scale's factor structure (factor analysis for dichotomous data based on tetrachoric correlation coefficients), internal consistency, and construct validity with measures of binge eating. Our results supported a 1-factor structure, which accounted for 54.1% of the variance. This tool had adequate reliability and high construct validity with measures of binge eating in this population, both in its diagnosis and symptom count version. A 2-factor structure explained an additional 9.1% of the variance, and could differentiate between patients with high, compared with low, levels of insight regarding addiction symptoms. In our study, we validated a psychometrically sound French version of the YFAS, both in its symptom count and diagnostic version. Future studies should validate this tool in clinical samples.

  5. On the sample transport time of a pneumatic transfer system

    International Nuclear Information System (INIS)

    Kondo, Yoshihide

    1983-01-01

    The counts accumulated in measuring system are affected by the variations in transport time of the sample on cyclic activation experiments with a mechanical sample transfer system. In use of the pneumatic transfer system, which has been set up, the transport time is variable according to the differences as follows: The form, size and weight of samples, the pneumatic pressure and so on. Comprehending the relationships between the transpot time and these variable factors is essentially important to make experiments with this transfer system. (author)

  6. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S

    2012-01-01

    The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new...

  7. Validation of the learning transfer system inventory in the South African context (Part 1

    Directory of Open Access Journals (Sweden)

    W J Coetsee

    2006-10-01

    Full Text Available The purpose of this study was to validate the Learning Transfer System Inventory (LTSI in the South African context. The sample used in this study was a convenience sample of 240 employees working for a Banking group. Exploratory factor analysis of the LTSI was used to determine if an interpretable factor structure of latent transfer system constructs when applied in the South African context could be identified. From the results it appears that the factor structure of the LTSI, as revealed by means of the exploratory approach, appears differently in the South African context.

  8. System Advisor Model: Flat Plate Photovoltaic Performance Modeling Validation Report

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, Janine [National Renewable Energy Lab. (NREL), Golden, CO (United States); Whitmore, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Kaffine, Leah [National Renewable Energy Lab. (NREL), Golden, CO (United States); Blair, Nate [National Renewable Energy Lab. (NREL), Golden, CO (United States); Dobos, Aron P. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-12-01

    The System Advisor Model (SAM) is a free software tool that performs detailed analysis of both system performance and system financing for a variety of renewable energy technologies. This report provides detailed validation of the SAM flat plate photovoltaic performance model by comparing SAM-modeled PV system generation data to actual measured production data for nine PV systems ranging from 75 kW to greater than 25 MW in size. The results show strong agreement between SAM predictions and field data, with annualized prediction error below 3% for all fixed tilt cases and below 8% for all one axis tracked cases. The analysis concludes that snow cover and system outages are the primary sources of disagreement, and other deviations resulting from seasonal biases in the irradiation models and one axis tracking issues are discussed in detail.

  9. Validation of the VTT's reactor physics code system

    International Nuclear Information System (INIS)

    Tanskanen, A.

    1998-01-01

    At VTT Energy several international reactor physics codes and nuclear data libraries are used in a variety of applications. The codes and libraries are under constant development and every now and then new updated versions are released, which are taken in use as soon as they have been validated at VTT Energy. The primary aim of the validation is to ensure that the code works properly, and that it can be used correctly. Moreover, the applicability of the codes and libraries are studied in order to establish their advantages and weak points. The capability of generating program-specific nuclear data for different reactor physics codes starting from the same evaluated data is sometimes of great benefit. VTT Energy has acquired a nuclear data processing system based on the NJOY-94.105 and TRANSX-2.15 processing codes. The validity of the processing system has been demonstrated by generating pointwise (MCNP) and groupwise (ANISN) temperature-dependent cross section sets for the benchmark calculations of the Doppler coefficient of reactivity. At VTT Energy the KENO-VI three-dimensional Monte Carlo code is used in criticality safety analyses. The KENO-VI code and the 44GROUPNDF5 data library have been validated at VTT Energy against the ZR-6 and LR-0 critical experiments. Burnup Credit refers to the reduction in reactivity of burned nuclear fuel due to the change in composition during irradiation. VTT Energy has participated in the calculational VVER-440 burnup credit benchmark in order to validate criticality safety calculation tools. (orig.)

  10. Validity, Reliability, and Inertia of Four Different Temperature Capsule Systems.

    Science.gov (United States)

    Bongers, Coen C W G; Daanen, Hein A M; Bogerd, Cornelis P; Hopman, Maria T E; Eijsvogels, Thijs M H

    2018-01-01

    Telemetric temperature capsule systems are wireless, relatively noninvasive, and easily applicable in field conditions and have therefore great advantages for monitoring core body temperature. However, the accuracy and responsiveness of available capsule systems have not been compared previously. Therefore, the aim of this study was to examine the validity, reliability, and inertia characteristics of four ingestible temperature capsule systems (i.e., CorTemp, e-Celsius, myTemp, and VitalSense). Ten temperature capsules were examined for each system in a temperature-controlled water bath during three trials. The water bath temperature gradually increased from 33°C to 44°C in trials 1 and 2 to assess the validity and reliability, and from 36°C to 42°C in trial 3 to assess the inertia characteristics of the temperature capsules. A systematic difference between capsule and water bath temperature was found for CorTemp (0.077°C ± 0.040°C), e-Celsius (-0.081°C ± 0.055°C), myTemp (-0.003°C ± 0.006°C), and VitalSense (-0.017°C ± 0.023°C; P 0.05). Comparable inertia characteristics were found for CorTemp (25 ± 4 s), e-Celsius (21 ± 13 s), and myTemp (19 ± 2 s), whereas the VitalSense system responded more slowly (39 ± 6 s) to changes in water bath temperature (P inertia were observed between capsule systems, an excellent validity, test-retest reliability, and inertia was found for each system between 36°C and 44°C after removal of outliers.

  11. The relationship between external and internal validity of randomized controlled trials: A sample of hypertension trials from China.

    Science.gov (United States)

    Zhang, Xin; Wu, Yuxia; Ren, Pengwei; Liu, Xueting; Kang, Deying

    2015-10-30

    To explore the relationship between the external validity and the internal validity of hypertension RCTs conducted in China. Comprehensive literature searches were performed in Medline, Embase, Cochrane Central Register of Controlled Trials (CCTR), CBMdisc (Chinese biomedical literature database), CNKI (China National Knowledge Infrastructure/China Academic Journals Full-text Database) and VIP (Chinese scientific journals database) as well as advanced search strategies were used to locate hypertension RCTs. The risk of bias in RCTs was assessed by a modified scale, Jadad scale respectively, and then studies with 3 or more grading scores were included for the purpose of evaluating of external validity. A data extract form including 4 domains and 25 items was used to explore relationship of the external validity and the internal validity. Statistic analyses were performed by using SPSS software, version 21.0 (SPSS, Chicago, IL). 226 hypertension RCTs were included for final analysis. RCTs conducted in university affiliated hospitals (P internal validity. Multi-center studies (median = 4.0, IQR = 2.0) were scored higher internal validity score than single-center studies (median = 3.0, IQR = 1.0) (P internal validity (P = 0.004). Multivariate regression indicated sample size, industry-funding, quality of life (QOL) taken as measure and the university affiliated hospital as trial setting had statistical significance (P external validity of RCTs do associate with the internal validity, that do not stand in an easy relationship to each other. Regarding the poor reporting, other possible links between two variables need to trace in the future methodological researches.

  12. A novel storage system for cryoEM samples.

    Science.gov (United States)

    Scapin, Giovanna; Prosise, Winifred W; Wismer, Michael K; Strickland, Corey

    2017-07-01

    We present here a new CryoEM grid boxes storage system designed to simplify sample labeling, tracking and retrieval. The system is based on the crystal pucks widely used by the X-ray crystallographic community for storage and shipping of crystals. This system is suitable for any cryoEM laboratory, but especially for large facilities that will need accurate tracking of large numbers of samples coming from different sources. Copyright © 2017. Published by Elsevier Inc.

  13. Importance sampling of rare events in chaotic systems

    DEFF Research Database (Denmark)

    Leitão, Jorge C.; Parente Lopes, João M.Viana; Altmann, Eduardo G.

    2017-01-01

    space of chaotic systems. As examples of our general framework we compute the distribution of finite-time Lyapunov exponents (in different chaotic maps) and the distribution of escape times (in transient-chaos problems). Our methods sample exponentially rare states in polynomial number of samples (in......Finding and sampling rare trajectories in dynamical systems is a difficult computational task underlying numerous problems and applications. In this paper we show how to construct Metropolis-Hastings Monte-Carlo methods that can efficiently sample rare trajectories in the (extremely rough) phase...... both low- and high-dimensional systems). An open-source software that implements our algorithms and reproduces our results can be found in reference [J. Leitao, A library to sample chaotic systems, 2017, https://github.com/jorgecarleitao/chaospp]....

  14. System for Packaging Planetary Samples for Return to Earth

    Science.gov (United States)

    Badescu, Mircea; Bar-Cohen, Yoseph; Backes, paul G.; Sherrit, Stewart; Bao, Xiaoqi; Scott, James S.

    2010-01-01

    A system is proposed for packaging material samples on a remote planet (especially Mars) in sealed sample tubes in preparation for later return to Earth. The sample tubes (Figure 1) would comprise (1) tubes initially having open tops and closed bottoms; (2) small, bellows-like collapsible bodies inside the tubes at their bottoms; and (3) plugs to be eventually used to close the tops of the tubes. The top inner surface of each tube would be coated with solder. The side of each plug, which would fit snugly into a tube, would feature a solder-filled ring groove. The system would include equipment for storing, manipulating, filling, and sealing the tubes. The containerization system (see Figure 2) will be organized in stations and will include: the storage station, the loading station, and the heating station. These stations can be structured in circular or linear pattern to minimize the manipulator complexity, allowing for compact design and mass efficiency. The manipulation of the sample tube between stations is done by a simple manipulator arm. The storage station contains the unloaded sample tubes and the plugs before sealing as well as the sealed sample tubes with samples after loading and sealing. The chambers at the storage station also allow for plug insertion into the sample tube. At the loading station the sample is poured or inserted into the sample tube and then the tube is topped off. At the heating station the plug is heated so the solder ring melts and seals the plug to the sample tube. The process is performed as follows: Each tube is filled or slightly overfilled with sample material and the excess sample material is wiped off the top. Then, the plug is inserted into the top section of the tube packing the sample material against the collapsible bellowslike body allowing the accommodation of the sample volume. The plug and the top of the tube are heated momentarily to melt the solder in order to seal the tube.

  15. DSM-5 antisocial personality disorder: predictive validity in a prison sample.

    Science.gov (United States)

    Edens, John F; Kelley, Shannon E; Lilienfeld, Scott O; Skeem, Jennifer L; Douglas, Kevin S

    2015-04-01

    Symptoms of antisocial personality disorder (ASPD), particularly remorselessness, are frequently introduced in legal settings as a risk factor for future violence in prison, despite a paucity of research on the predictive validity of this disorder. We examined whether an ASPD diagnosis or symptom-criteria counts could prospectively predict any form of institutional misconduct, as well as aggressive and violent infractions among newly admitted prisoners. Adult male (n = 298) and female (n = 55) offenders were recruited from 4 prison systems across the United States. At the time of study enrollment, diagnostic information was collected using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV; APA, 1994) Axis II Personality Disorders (SCID-II; First, Gibbon, Spitzer, Williams, & Benjamin, 1997) supplemented by a detailed review of official records. Disciplinary records were obtained from inmates' respective prisons covering a 1-year period following study enrollment and misconduct was categorized hierarchically as any (general), aggressive (verbal/physical), or violent (physical). Dichotomous ASPD diagnoses and adult symptom-criteria counts did not significantly predict institutional misconduct across our 3 outcome variables, with effect sizes being close to 0 in magnitude. The symptom of remorselessness in particular showed no relation to future misconduct in prison. Childhood symptom counts of conduct disorder demonstrated modest predictive utility. Our results offer essentially no support for the claim that ASPD diagnoses can predict institutional misconduct in prison, regardless of the number of adult symptoms present. In forensic contexts, testimony that an ASPD diagnosis identifies defendants who will pose a serious threat while incarcerated in prison presently lacks any substantial scientific foundation. (c) 2015 APA, all rights reserved).

  16. DESIGN AND VALIDATION OF AN INTERORGANIZATIONAL INFORMATION SYSTEM

    Directory of Open Access Journals (Sweden)

    Kamel Rouibah

    2006-01-01

    Full Text Available This paper presents an interorganizational information system that aims to structure collaboration of engineering activities as well as data sharing across company borders. The paper also describes the approach underlying the system, validates it by designing a system prototype, and tests the system using questionnaire and in-depth interviews in order to further knowledge about the subject. The main results from the test show: collaboration engineering is potentially important for senior managers; end-users were specifically attracted more by the concept rather by its implementation; engineering change management is a complex process; and the support of strategic level is a critical success factor. In addition, the paper describes other factors that emerged during the ongoing project and inhibit success of the system.

  17. A Simulation Approach for Performance Validation during Embedded Systems Design

    Science.gov (United States)

    Wang, Zhonglei; Haberl, Wolfgang; Herkersdorf, Andreas; Wechs, Martin

    Due to the time-to-market pressure, it is highly desirable to design hardware and software of embedded systems in parallel. However, hardware and software are developed mostly using very different methods, so that performance evaluation and validation of the whole system is not an easy task. In this paper, we propose a simulation approach to bridge the gap between model-driven software development and simulation based hardware design, by merging hardware and software models into a SystemC based simulation environment. An automated procedure has been established to generate software simulation models from formal models, while the hardware design is originally modeled in SystemC. As the simulation models are annotated with timing information, performance issues are tackled in the same pass as system functionality, rather than in a dedicated approach.

  18. Games and Scenarios for Real-Time System Validation

    DEFF Research Database (Denmark)

    Li, Shuhao

    This thesis presents research on the validation of real-time embedded software systems in the context of model-based development. The thesis proposes scenario-based and game-theoretic approaches to system analysis, verification, synthesis and testing to address the challenges that arise from....... By linking our prototype translators with existing model checker Uppaal and game solver Uppaal-Tiga, we show that these methods contribute to the interaction correctness and timeliness of early system designs. The thesis also shows that testing a real-time reactive system can be viewed as playing a timed...... communicating real-time systems can be modeled and specified with LSC. By translating LSC to timed automata (TAs), we reduce scenario-based model consistency checking and property verification to CTL real-time model checking problems, and reduce scenario-based synthesis to a timed game solving problem...

  19. January 2011 Groundwater Sampling at the Gnome-Coach, New Mexico, Site (Data Validation Package)

    International Nuclear Information System (INIS)

    2011-01-01

    Annual sampling was conducted January 19, 2011, to monitor groundwater for potential radionuclide contamination at the Gnome-Coach site in New Mexico. The sampling was performed as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PLN/S04351, continually updated). Well LRL-7 was not sampled per instruction from the lead. A duplicate sample was collected from well USGS-1.Water levels were measured in the monitoring wells onsite.

  20. Validation of a Portuguese Version of the Snyder Hope Scale in a Sample of High School Students

    Science.gov (United States)

    Marques, Susana C.; Lopez, Shane J.; Fontaine, Anne Marie; Coimbra, Susana; Mitchell, Joanna

    2014-01-01

    C. R. Snyder conceptualized hope as a cognitive construct that reflects people's motivation and capacity to strive toward personally relevant goals. Using this definition, Snyder and colleagues developed and validated the Hope Scale (HS). This study is the first study to examine the psychometric properties of the HS in a sample of high school…

  1. Active Fault Diagnosis in Sampled-data Systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Poulsen, Niels Kjølstad

    2015-01-01

    The focus in this paper is on active fault diagnosis (AFD) in closed-loop sampleddata systems. Applying the same AFD architecture as for continuous-time systems does not directly result in the same set of closed-loop matrix transfer functions. For continuous-time systems, the LFT (linear fractional...... transformation) structure in the connection between the parametric faults and the matrix transfer function (also known as the fault signature matrix) applied for AFD is not directly preserved for sampled-data system. As a consequence of this, the AFD methods cannot directly be applied for sampled-data systems....... Two methods are considered in this paper to handle the fault signature matrix for sampled-data systems such that standard AFD methods can be applied. The first method is based on a discretization of the system such that the LFT structure is preserved resulting in the same LFT structure in the fault...

  2. Expert system verification and validation survey. Delivery 3: Recommendations

    Science.gov (United States)

    1990-01-01

    The purpose is to determine the state-of-the-practice in Verification and Validation (V and V) of Expert Systems (ESs) on current NASA and Industry applications. This is the first task of a series which has the ultimate purpose of ensuring that adequate ES V and V tools and techniques are available for Space Station Knowledge Based Systems development. The strategy for determining the state-of-the-practice is to check how well each of the known ES V and V issues are being addressed and to what extent they have impacted the development of ESs.

  3. Use of robotic systems for radiochemical sample changing and for analytical sample preparation

    International Nuclear Information System (INIS)

    Delmastro, J.R.; Hartenstein, S.D.; Wade, M.A.

    1989-01-01

    Two uses of the Perkin-Elmer (PE) robotic system will be presented. In the first, a PE robot functions as an automatic sample changer for up to five low energy photon spectrometry (LEPS) detectors operated with a Nuclear Data ND 6700 system. The entire system, including the robot, is controlled by an IBM PC-AT using software written in compiled BASIC. Problems associated with the development of the system and modifications to the robot will be presented. In the second, an evaluation study was performed to assess the abilities of the PE robotic system for performing complex analytical sample preparation procedures. For this study, a robotic system based upon the PE robot and auxiliary devices was constructed and programmed to perform the preparation of final product samples (UO 3 ) for accountability and impurity specification analyses. These procedures require sample dissolution, dilution, and liquid-liquid extraction steps. The results of an in-depth evaluation of all system components will be presented

  4. Improvement of Simulation Method in Validation of Software of the Coordinate Measuring Systems

    Science.gov (United States)

    Nieciąg, Halina

    2015-10-01

    Software is used in order to accomplish various tasks at each stage of the functioning of modern measuring systems. Before metrological confirmation of measuring equipment, the system has to be validated. This paper discusses the method for conducting validation studies of a fragment of software to calculate the values of measurands. Due to the number and nature of the variables affecting the coordinate measurement results and the complex character and multi-dimensionality of measurands, the study used the Monte Carlo method of numerical simulation. The article presents an attempt of possible improvement of results obtained by classic Monte Carlo tools. The algorithm LHS (Latin Hypercube Sampling) was implemented as alternative to the simple sampling schema of classic algorithm.

  5. Improvement of Simulation Method in Validation of Software of the Coordinate Measuring Systems

    Directory of Open Access Journals (Sweden)

    Nieciąg Halina

    2015-10-01

    Full Text Available Software is used in order to accomplish various tasks at each stage of the functioning of modern measuring systems. Before metrological confirmation of measuring equipment, the system has to be validated. This paper discusses the method for conducting validation studies of a fragment of software to calculate the values of measurands. Due to the number and nature of the variables affecting the coordinate measurement results and the complex character and multi-dimensionality of measurands, the study used the Monte Carlo method of numerical simulation. The article presents an attempt of possible improvement of results obtained by classic Monte Carlo tools. The algorithm LHS (Latin Hypercube Sampling was implemented as alternative to the simple sampling schema of classic algorithm.

  6. Water and steam sampling systems; Provtagningssystem foer vatten och aanga

    Energy Technology Data Exchange (ETDEWEB)

    Hellman, Mats

    2009-10-15

    The supervision of cycle chemistry can be divided into two parts, the sampling system and the chemical analysis. In modern steam generating plants most of the chemical analyses are carried out on-line. The detection limits of these analyzers are pushed downward to the ppt-range (parts per trillion), however the analyses are not more correct than the accuracy of the sampling system. A lot of attention has been put to the analyzers and the statistics to interpret the results but the sampling procedures has gained much less attention. This report aims to give guidance of the considerations to be made regarding sampling systems. Sampling is necessary since most analysis of interesting parameters cannot be carried out in- situ on-line in the steam cycle. Today's on-line instruments for pH, conductivity, silica etc. are designed to meet a water sample at a temperature of 10-30 deg C. This means that the sampling system has to extract a representative sample from the process, transport and cool it down to room temperature without changing the characteristics of the fluid. In the literature research work, standards and other reports can be found. Although giving similar recommendations in most aspects there are some discrepancies that may be confusing. This report covers all parts in the sampling system: Sample points and nozzles; Sample lines; Valves, regulating and on-off; Sample coolers; Temperature, pressure and flow rate control; Cooling water; and Water recovery. On-line analyzers connecting to the sampling system are not covered. This report aims to clarify what guidelines are most appropriate amongst the existing ones. The report should also give guidance to the design of the sampling system in order to achieve representative samples. In addition to this the report gives an overview of the fluid mechanics involved in sampling. The target group of this report is owners and operators of steam generators, vendors of power plant equipment, consultants working in

  7. Non-Contact Conductivity Measurement for Automated Sample Processing Systems

    Science.gov (United States)

    Beegle, Luther W.; Kirby, James P.

    2012-01-01

    A new method has been developed for monitoring and control of automated sample processing and preparation especially focusing on desalting of samples before analytical analysis (described in more detail in Automated Desalting Apparatus, (NPO-45428), NASA Tech Briefs, Vol. 34, No. 8 (August 2010), page 44). The use of non-contact conductivity probes, one at the inlet and one at the outlet of the solid phase sample preparation media, allows monitoring of the process, and acts as a trigger for the start of the next step in the sequence (see figure). At each step of the muti-step process, the system is flushed with low-conductivity water, which sets the system back to an overall low-conductivity state. This measurement then triggers the next stage of sample processing protocols, and greatly minimizes use of consumables. In the case of amino acid sample preparation for desalting, the conductivity measurement will define three key conditions for the sample preparation process. First, when the system is neutralized (low conductivity, by washing with excess de-ionized water); second, when the system is acidified, by washing with a strong acid (high conductivity); and third, when the system is at a basic condition of high pH (high conductivity). Taken together, this non-contact conductivity measurement for monitoring sample preparation will not only facilitate automation of the sample preparation and processing, but will also act as a way to optimize the operational time and use of consumables

  8. Development of an expert system for signal validation: Topical report

    International Nuclear Information System (INIS)

    Qualls, A.L.; Uhrig, R.E.; Upadhyaya, B.R.

    1988-07-01

    A signal validation and sensor information expert system is developed and applied to nuclear power plant subsystems. The expert system interactively provides the user with a list of sensors used to monitor a subsystem of a power plant and answers the user's questions about the characteristics of those sensors. The expert system performs an evaluation of the present output characteristics of an instrument channel. The evaluation is fully automated and is designed to mimic an operator's approach to signal validation. The evaluation is designed to detect three types of possible sensor anomalies: (1) incorrect average output, (2) improper noise level,and (3) incorrect response to a system perturbation. There are two tests used to detect each possible anomalous condition. One test is a comparison of the specified sensor characteristic against the same characteristic of its redundant sensors. The second test is a prediction of the sensor's expected behavior and comparison with its observed behavior. The evaluation was tested using operational data from twelve sensors used to monitor level, pressure, primary and secondary coolant flow rates, and hot and cold leg temperatures of a steam generator in a commercial nuclear power plant. The results of the testing demonstrated successfully that the evaluation detected the three possible anomalies, and was able to handle conflicting information using the comparison among redundant sensors and the system specific test used to detect the anomalies

  9. A large-scale cryoelectronic system for biological sample banking

    Science.gov (United States)

    Shirley, Stephen G.; Durst, Christopher H. P.; Fuchs, Christian C.; Zimmermann, Heiko; Ihmig, Frank R.

    2009-11-01

    We describe a polymorphic electronic infrastructure for managing biological samples stored over liquid nitrogen. As part of this system we have developed new cryocontainers and carrier plates attached to Flash memory chips to have a redundant and portable set of data at each sample. Our experimental investigations show that basic Flash operation and endurance is adequate for the application down to liquid nitrogen temperatures. This identification technology can provide the best sample identification, documentation and tracking that brings added value to each sample. The first application of the system is in a worldwide collaborative research towards the production of an AIDS vaccine. The functionality and versatility of the system can lead to an essential optimization of sample and data exchange for global clinical studies.

  10. Computational design and experimental validation of new thermal barrier systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin [Louisiana State Univ., Baton Rouge, LA (United States)

    2015-03-31

    The focus of this project is on the development of a reliable and efficient ab initio based computational high temperature material design method which can be used to assist the Thermal Barrier Coating (TBC) bond-coat and top-coat design. Experimental evaluations on the new TBCs are conducted to confirm the new TBCs’ properties. Southern University is the subcontractor on this project with a focus on the computational simulation method development. We have performed ab initio density functional theory (DFT) method and molecular dynamics simulation on screening the top coats and bond coats for gas turbine thermal barrier coating design and validation applications. For experimental validations, our focus is on the hot corrosion performance of different TBC systems. For example, for one of the top coatings studied, we examined the thermal stability of TaZr2.75O8 and confirmed it’s hot corrosion performance.

  11. Thermal hydraulics of accelerator driven system: validation and analysis

    International Nuclear Information System (INIS)

    Kumari, I.; Khanna, A.

    2014-01-01

    This paper presents validation of RELAP5/Mod4.0 code modified to incorporate Lead Bismuth Eutectic (LBE)fluid properties for simulation of Accelerator Driven System (ADS) against Barone's NACIE facility.Results of mass flow rates (MFR), Reynolds number, heat transfer coefficients, temperatures and temperature difference for three powers (10.8, 21.7 and 32.5 kW) under natural circulation of LBE match with Barone's values within 7%,18%,37%, 5% and 8% of relative error respectively. After this validation Indian ADS for thermal power of 15 kW has been simulated. Simulated profiles of temperature, MFR and pressure drop LBE and air are reported. Air and LBE temperatures of present work match with literature design values within 5% of relative error. (author)

  12. Correction of Sample-Time Error for Time-Interleaved Sampling System Using Cubic Spline Interpolation

    Directory of Open Access Journals (Sweden)

    Qin Guo-jie

    2014-08-01

    Full Text Available Sample-time errors can greatly degrade the dynamic range of a time-interleaved sampling system. In this paper, a novel correction technique employing a cubic spline interpolation is proposed for inter-channel sample-time error compensation. The cubic spline interpolation compensation filter is developed in the form of a finite-impulse response (FIR filter structure. The correction method of the interpolation compensation filter coefficients is deduced. A 4GS/s two-channel, time-interleaved ADC prototype system has been implemented to evaluate the performance of the technique. The experimental results showed that the correction technique is effective to attenuate the spurious spurs and improve the dynamic performance of the system.

  13. Methods and practices for verification and validation of programmable systems

    International Nuclear Information System (INIS)

    Heimbuerger, H.; Haapanen, P.; Pulkkinen, U.

    1993-01-01

    The programmable systems deviate by their properties and behaviour from the conventional non-programmable systems in such extent, that their verification and validation for safety critical applications requires new methods and practices. The safety assessment can not be based on conventional probabilistic methods due to the difficulties in the quantification of the reliability of the software and hardware. The reliability estimate of the system must be based on qualitative arguments linked to a conservative claim limit. Due to the uncertainty of the quantitative reliability estimate other means must be used to get more assurance about the system safety. Methods and practices based on research done by VTT for STUK, are discussed in the paper as well as the methods applicable in the reliability analysis of software based safety functions. The most essential concepts and models of quantitative reliability analysis are described. The application of software models in probabilistic safety analysis (PSA) is evaluated. (author). 18 refs

  14. A study to confirm the reliability and construct validity of an organisational citizenship behaviour measure on a South African sample

    Directory of Open Access Journals (Sweden)

    Bright Mahembe

    2015-10-01

    Research purpose: The primary goal of the study was to validate the Organisational Citizenship Behaviour Scale (OCBS developed by Podsakoff, Mackenzie, Moorman and Fetter (1990 on a South African sample. Motivation for the study: Organisational citizenship behaviour is one of the important workplace outcomes. A psychometrically sound instrument is therefore required. Research design, approach and method: The sample consisted of 503 employees from the educational sector in the Eastern and Western Cape Provinces of South Africa. The OCBS was used to measure organisational citizenship behaviour. Main findings: High levels of reliability were found for the OCBS sub-scales. The first and second-order measurement models of the OCBS showed good fit. A competing one-factor model did not show good model fit. In terms of discriminant validity four of the five subdimensions correlated highly. Practical/managerial implications: Although the OCBS demonstrated some sound reliability coefficients and reasonable construct validity, the discriminant validity of four of the subscales raise some questions which future studies should confirm. The use of the instrument should help to continue to measure the much-needed extra-role behaviours that mirror an employee’s interest in the success of the organisation. Contribution/value-add: The study contributes to the requirements of the Employment Equity Act (No. 55 of 1998 and the Amended Employment Equity Act of South Africa (Republic of South Africa, 1998; 2014. This promotes the use of reliable and valid instruments in South Africa by confirming the psychometric properties of the OCBS.

  15. Incremental Validity of the Durand Adaptive Psychopathic Traits Questionnaire Above Self-Report Psychopathy Measures in Community Samples.

    Science.gov (United States)

    Durand, Guillaume

    2018-05-03

    Although highly debated, the notion of the existence of an adaptive side to psychopathy is supported by some researchers. Currently, 2 instruments assessing psychopathic traits include an adaptive component, which might not cover the full spectrum of adaptive psychopathic traits. The Durand Adaptive Psychopathic Traits Questionnaire (DAPTQ; Durand, 2017 ) is a 41-item self-reported instrument assessing adaptive traits known to correlate with the psychopathic personality. In this study, I investigated in 2 samples (N = 263 and N = 262) the incremental validity of the DAPTQ over the Psychopathic Personality Inventory-Short Form (PPI-SF) and the Triarchic Psychopathy Measure (TriPM) using multiple criterion measures. Results showed that the DAPTQ significantly increased the predictive validity over the PPI-SF on 5 factors of the HEXACO. Additionally, the DAPTQ provided incremental validity over both the PPI-SF and the TriPM on measures of communication adaptability, perceived stress, and trait anxiety. Overall, these results support the validity of the DAPTQ in community samples. Directions for future studies to further validate the DAPTQ are discussed.

  16. Data Validation Package May 2016 Groundwater Sampling at the Bluewater, New Mexico, Disposal Site, September 2016

    International Nuclear Information System (INIS)

    Johnson, Dick; Tsosie, Bernadette

    2016-01-01

    Groundwater samples were collected from monitoring wells at the Bluewater, New Mexico, Disposal Site to monitor groundwater contaminants as specified in the 1997 Long-Term Surveillance Plan for the DOE Bluewater (UMTRCA Title II) Disposal Site Near Grants, New Mexico (LTSP). Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location 16(SG).

  17. Data Validation Package May 2016 Groundwater Sampling at the Bluewater, New Mexico, Disposal Site, September 2016

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Dick [Navarro Nevada Environmental Services (NNES), Las Vegas, NV (United States); Tsosie, Bernadette [US Department of Energy, Washington, DC (United States)

    2016-09-01

    Groundwater samples were collected from monitoring wells at the Bluewater, New Mexico, Disposal Site to monitor groundwater contaminants as specified in the 1997 Long-Term Surveillance Plan for the DOE Bluewater (UMTRCA Title II) Disposal Site Near Grants, New Mexico (LTSP). Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location 16(SG).

  18. Robust H2 performance for sampled-data systems

    DEFF Research Database (Denmark)

    Rank, Mike Lind

    1997-01-01

    Robust H2 performance conditions under structured uncertainty, analogous to well known methods for H∞ performance, have recently emerged in both discrete and continuous-time. This paper considers the extension into uncertain sampled-data systems, taking into account inter-sample behavior. Convex...... conditions for robust H2 performance are derived for different uncertainty sets...

  19. Identification of continuous-time systems from samples of input ...

    Indian Academy of Sciences (India)

    Abstract. This paper presents an introductory survey of the methods that have been developed for identification of continuous-time systems from samples of input±output data. The two basic approaches may be described as (i) the indirect method, where first a discrete-time model is estimated from the sampled data and then ...

  20. Sample Management System for Heavy Ion Irradiation, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — A robotic sample management device and system for the exposure of biological and material specimens to heavy ion beams of the NASA Space Radiation Laboratory (NSRL)...

  1. Sample Management System for Heavy Ion Irradiation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — A robotic sample management device and system for the exposure of biological and material specimens to heavy ion beams of the NASA Space Radiation Laboratory (NSRL)...

  2. A rating system for post pulse data validation

    International Nuclear Information System (INIS)

    Buceti, G.; Centioli, Cristina; Iannone, F.; Panella, M.; Rizzo, A.; Vitale, V.

    2003-01-01

    The aim of an automatic data validation system in a fusion experiment is to account--after every shot--for any occurrence of faulty sensors and unreliable measurements, thus preventing the proliferation of poor pulse data. In the past years a prototype has been successfully developed at Frascati Tokamak Upgrade (FTU) on a small set of density measurements. The results have shown that the model can be further extended to plant and diagnostic data, and that the same system can be used to assign to raw data a quality factor, to be stored in the archive and to be used in the post-shot elaboration phase as a selection criterion. In this way, a data validation system can also provide data analysts with an useful tool to be used as a key--together with other significant parameters, like plasma current, or magnetic field--to search the archive for quality data. This paper will describe how, using soft computing techniques, both these functions have been implemented on FTU, providing the users with a simple interface for fault detection developed in an open source environment (PHP-MySQL), to be finalised into the realisation of an overall rating system for FTU data

  3. A rating system for post pulse data validation

    Energy Technology Data Exchange (ETDEWEB)

    Buceti, G.; Centioli, Cristina E-mail: centioli@frascati.enea.it; Iannone, F.; Panella, M.; Rizzo, A.; Vitale, V

    2003-09-01

    The aim of an automatic data validation system in a fusion experiment is to account--after every shot--for any occurrence of faulty sensors and unreliable measurements, thus preventing the proliferation of poor pulse data. In the past years a prototype has been successfully developed at Frascati Tokamak Upgrade (FTU) on a small set of density measurements. The results have shown that the model can be further extended to plant and diagnostic data, and that the same system can be used to assign to raw data a quality factor, to be stored in the archive and to be used in the post-shot elaboration phase as a selection criterion. In this way, a data validation system can also provide data analysts with an useful tool to be used as a key--together with other significant parameters, like plasma current, or magnetic field--to search the archive for quality data. This paper will describe how, using soft computing techniques, both these functions have been implemented on FTU, providing the users with a simple interface for fault detection developed in an open source environment (PHP-MySQL), to be finalised into the realisation of an overall rating system for FTU data.

  4. Development and validation of novel digitalized cervicography system

    Science.gov (United States)

    Kim, Soo-Nyung; Kim, Yun Hwan; Nam, Kye-Hyun; Lee, Seon-Kyung; Lee, Tae Sung; Choi, Ho-Sun; Han, Sei-Jun

    2016-01-01

    Objective Digital cervicography systems would be expected to reduce the costs of film cervicography, and provide the opportunity for "telemedicine-based" screening. We aimed to develop web-based digital cervicography system, and validate it compared with conventional film cervicography. Methods A hundred cases from five centers were prospectively included, and cervical images (analogue, digitalized by scanning analogue, and digital) were taken separately using both analogue (Cerviscope) and digital camera (Dr. Cervicam) in each patient. Nine specialists evaluated the three kinds of images of each case with time interval between evaluations of each image. To validate novel digitalized system, we analyzed intra-observer variance among evaluation results of three kinds of images. Results Sixty-three cases were finally analyzed after excluding technically defective cases that cannot be evaluable on analogue images. The generalized kappa for analogue versus digital image was 0.83, for analogue versus scanned image 0.72, and for digital versus scanned image was 0.71; all were in excellent consensus. Conclusion Digitalized cervicography system can be substituted for the film cervicography very reliably, and can be used as a promising telemedicine tool for cervical cancer screening. PMID:27200314

  5. Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample.

    Science.gov (United States)

    Burri, Andrea; Porst, Hartmut

    2018-06-01

    To date, neither the original English nor any of the translated versions of the Sexual Complaints Screener for Women (SCS-W) have been tested for their psychometric properties. To evaluate the validity and utility of the German version of the SCS-W by assessing content, convergent, and discriminant validity. A population sample of 309 women (mean age = 26.9 years) completed the online survey and had matching data available on the SCS-W and the Female Sexual Function Index (FSFI). Spearman bivariate correlations between the SCS-W and FSFI domain scores and exploratory factor analysis with principal component analysis were conducted. Convergent validity was excellent for the domain of orgasm, good for satisfaction, dyspareunia, and the total questionnaire score, and acceptable for desire, lubrication, arousal, and vaginismus. Discriminant validity was present for all domains apart from arousal, lubrication, and vaginismus. Varimax rotation suggested an 8-factor model was the most robust. This brief screener seems suitable to provide a brief overview of female patients' sexual problems in a clinical setting. This is the 1st study to assess the psychometric properties of the German version of the SCS-W. However, available information on the psychometric properties of the German SCS-W was limited because the validity of the screener could not be counterchecked against a clinical diagnosis of female sexual dysfunction. Our results provide preliminary evidence of good validity of the German version of the SCS-W. Overall, the SCS-W can offer support for clinicians who are less familiar with sexual medicine and who might not routinely discuss sexual issues with their patients. Burri A, Porst H. Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample. Sex Med 2018;6:123-130. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  6. January 2012 Groundwater Sampling at the Gnome-Coach, New Mexico, Site (Data Validation Package)

    International Nuclear Information System (INIS)

    2012-01-01

    Annual sampling was conducted January 18, 2012, to monitor groundwater for potential radionuclide contamination at the Gnome-Coach site in New Mexico. The sampling was performed as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PLN/S04351, continually updated). Well LRL-7 was not sampled per instruction from the lead. A duplicate sample was collected from well USGS-1 and water levels were measured in the monitoring wells onsite.

  7. January 2012 Groundwater Sampling at the Gnome-Coach, New Mexico, Site (Data Validation Package)

    Energy Technology Data Exchange (ETDEWEB)

    Findlay, Richard C. [S.M. Stoller Corporation, Broomfield, CO (United States)

    2012-12-01

    Annual sampling was conducted January 18, 2012, to monitor groundwater for potential radionuclide contamination at the Gnome-Coach site in New Mexico. The sampling was performed as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PLN/S04351, continually updated). Well LRL-7 was not sampled per instruction from the lead. A duplicate sample was collected from well USGS-1 and water levels were measured in the monitoring wells onsite.

  8. May 2013 Groundwater and Surface Water Sampling at the Rio Blanco, Colorado, Site (Data Validation Package)

    Energy Technology Data Exchange (ETDEWEB)

    Hutton, Rick [S.M. Stoller Corporation, Broomfield, CO (United States)

    2013-10-01

    Annual sampling was conducted at the Rio Blanco, Colorado, site for the Long-Term Hydrologic Monitoring Program May 14-16, 2013, to monitor groundwater and surface water for potential radionuclide contamination. Sampling and analyses were conducted as specified in Sampling and Analysis Plan for the U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location CER #1 Black Sulphur. Samples were analyzed for gamma-emitting radionuclides by high-resolution gamma spectrometry and for tritium using the conventional and enrichment methods.

  9. Construct Validity of the Posttraumatic Stress Disorder Checklist in Cancer Survivors: Analyses Based on Two Samples

    Science.gov (United States)

    DuHamel, Katherine N.; Ostrof, Jamie; Ashman, Teresa; Winkel, Gary; Mundy, Elizabeth A.; Keane, Terence M.; Morasco, Benjamin J.; Vickberg, Suzanne M. J.; Hurley, Karen; Chhabra, Rosy; Scigliano, Eileen; Papadopoulos, Esperanza; Moskowitz, Craig; Redd, William

    2004-01-01

    The measurement of posttraumatic stress disorder (PTSD) is critically important for the identification and treatment of this disorder. The PTSD Checklist (PCL; F. W. Weathers & J. Ford, 1996) is a self-report measure that is increasingly used. In this study, the authors investigated the factorial validity of the PCL with data from 236 cancer…

  10. Validation of the Temporal Satisfaction with Life Scale in a Sample of Chinese University Students

    Science.gov (United States)

    Ye, Shengquan

    2007-01-01

    The study aims at validating the Temporal Satisfaction With Life Scale (TSWLS; Pavot et al., 1998, "The Temporal Satisfaction With Life Scale", Journal of Personality Assessment 70, pp. 340-354) in a non-western context. Data from 646 Chinese university students (330 females and 316 males) supported the three-factor structure of the…

  11. Deviant behavior variety scale: development and validation with a sample of Portuguese adolescents

    Directory of Open Access Journals (Sweden)

    Cristina Sanches

    2016-01-01

    Full Text Available Abstract This study presents the development and analysis of the psychometric properties of the Deviant Behavior Variety Scale (DBVS. Participants were 861 Portuguese adolescents (54 % female, aged between 12 and 19 years old. Two alternative models were tested using Confirmatory Factor Analysis. Although both models showed good fit indexes, the two-factor model didn’t presented discriminant validity. Further results provided evidence for the factorial and the convergent validity of the single-factor structure of the DVBS, which has also shown good internal consistency. Criterion validity was evaluated through the association with related variables, such as age and school failure, as well as the scale’s ability to capture group differences, namely between genders and school retentions, and finally by comparing a sub-group of convicted adolescents with a group of non-convicted ones regarding their engagement in delinquent activities. Overall, the scale presented good psychometric properties, with results supporting that the DBVS is a valid and reliable self-reported measure to evaluate adolescents’ involvement in deviance.

  12. Concurrent Validity of the Psychopathic Personality Inventory with Offender and Community Samples

    Science.gov (United States)

    Malterer, Melanie B.; Lilienfeld, Scott O.; Neumann, Craig S.; Newman, Joseph P.

    2010-01-01

    The Psychopathy Checklist-Revised (PCL-R) is a frequently used and well-validated measure of psychopathy but is relatively time-intensive and expensive to administer. The Psychopathic Personality Inventory (PPI) is a self-report measure that provides a less time-intensive and less expensive method for identifying psychopathic individuals. Using…

  13. Construct Validity of the WISC-IV with a Referred Sample: Direct versus Indirect Hierarchical Structures

    Science.gov (United States)

    Canivez, Gary L.

    2014-01-01

    The Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) is one of the most frequently used intelligence tests in clinical assessments of children with learning difficulties. Construct validity studies of the WISC-IV have generally supported the higher order structure with four correlated first-order factors and one higher-order…

  14. Construct Validity of the WISC-IV[superscript UK] with a Large Referred Irish Sample

    Science.gov (United States)

    Watkins, Marley W.; Canivez, Gary L.; James, Trevor; James, Kate; Good, Rebecca

    2013-01-01

    Irish educational psychologists frequently use the Wechsler Intelligence Scale for Children-Fourth U.K. Edition (WISC-IV[superscript UK]) in clinical assessments of children with learning difficulties. Unfortunately, reliability and validity studies of the WISC-IV[superscript UK] have not yet been reported. This study examined the construct…

  15. Validity of Suicidality Items from the Youth Risk Behavior Survey in a High School Sample

    Science.gov (United States)

    May, Alexis; Klonsky, E. David

    2011-01-01

    The Youth Risk Behavior Survey (YRBS) is used by the United States Centers for Disease Control to estimate rates of suicidal thoughts and behaviors in adolescents. This study investigated the validity of the YRBS suicidality items by examining their relationship to criterion variables including loneliness, anxiety, depression, substance use, and…

  16. Empirical validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for suspected Lyme disease.

    Science.gov (United States)

    Citera, Maryalice; Freeman, Phyllis R; Horowitz, Richard I

    2017-01-01

    Lyme disease is spreading worldwide, with multiple Borrelia species causing a broad range of clinical symptoms that mimic other illnesses. A validated Lyme disease screening questionnaire would be clinically useful for both providers and patients. Three studies evaluated such a screening tool, namely the Horowitz Multiple Systemic Infectious Disease Syndrome (MSIDS) Questionnaire. The purpose was to see if the questionnaire could accurately distinguish between Lyme patients and healthy individuals. Study 1 examined the construct validity of the scale examining its factor structure and reliability of the questionnaire among 537 individuals being treated for Lyme disease. Study 2 involved an online sample of 999 participants, who self-identified as either healthy (N=217) or suffering from Lyme now (N=782) who completed the Horowitz MSIDS Questionnaire (HMQ) along with an outdoor activity survey. We examined convergent validity among components of the scale and evaluated discriminant validity with the Big Five personality characteristics. The third study compared a sample of 236 patients with confirmed Lyme disease with an online sample of 568 healthy individuals. Factor analysis results identified six underlying latent dimensions; four of these overlapped with critical symptoms identified by Horowitz - neuropathy, cognitive dysfunction, musculoskeletal pain, and fatigue. The HMQ showed acceptable levels of internal reliability using Cronbach's coefficient alpha and exhibited evidence of convergent and divergent validity. Components of the HMQ correlated more highly with each other than with unrelated traits. The results consistently demonstrated that the HMQ accurately differentiated those with Lyme disease from healthy individuals. Three migratory pain survey items (persistent muscular pain, arthritic pain, and nerve pain/paresthesias) robustly identified individuals with verified Lyme disease. The results support the use of the HMQ as a valid, efficient, and low

  17. A Human Proximity Operations System test case validation approach

    Science.gov (United States)

    Huber, Justin; Straub, Jeremy

    A Human Proximity Operations System (HPOS) poses numerous risks in a real world environment. These risks range from mundane tasks such as avoiding walls and fixed obstacles to the critical need to keep people and processes safe in the context of the HPOS's situation-specific decision making. Validating the performance of an HPOS, which must operate in a real-world environment, is an ill posed problem due to the complexity that is introduced by erratic (non-computer) actors. In order to prove the HPOS's usefulness, test cases must be generated to simulate possible actions of these actors, so the HPOS can be shown to be able perform safely in environments where it will be operated. The HPOS must demonstrate its ability to be as safe as a human, across a wide range of foreseeable circumstances. This paper evaluates the use of test cases to validate HPOS performance and utility. It considers an HPOS's safe performance in the context of a common human activity, moving through a crowded corridor, and extrapolates (based on this) to the suitability of using test cases for AI validation in other areas of prospective application.

  18. On the validity of collective variable description of Bose systems

    International Nuclear Information System (INIS)

    Takahashi, Minoru

    1975-01-01

    The validity of Sunakawa, Yamasaki and Kebukawa's Hamiltonian and that of Bogoliubov and Zubarev's Hamiltonian are examined. Perturbational expansion of the ground state energy by these Hamiltonians disagrees with the exact solution of Lieb and Liniger for one-dimensional Bose system with repulsive delta-function interaction. This fact suggests that these Hamiltonians are not microscopic descriptions of the many-Boson system. Mathematical inconsistency in Bogoliubov and Zubarev's theory is also pointed out. Moreover analytic expression of high density expansion for the ground state energy density e 0 is found out to be e 0 n -3 =γ-(4/3π)γsup(3/2)+(1/6-1/π 2 )γ 2 +O(γsup(5/2)), γ=c/n, for one-dimensional Bose system with delta function interaction (density n, strength 2c, h=2m=1) by the use of the correlated basis function method. (auth.)

  19. Use of simulators for validation of advanced plant monitoring systems

    Energy Technology Data Exchange (ETDEWEB)

    Uytterhoeven, G.; Vlaminck, M. De [Belgatom, Brussels (Belgium); Javaux, D. [Cognitive Ergonomics Work-Psychology Department, University of Liege, Sart-Tilman (Belgium)

    1999-07-01

    This paper describes how the full-scope nuclear power plant simulator of Doel (Belgium) was used to assess Situation Awareness for the validation of a process monitoring and supervision system, named DIMOS. The method (derived from a method originally developed for the aerospace industry) has been adapted and applied to compare the efficiency of two versions of the monitoring system: Alarm-masking and non alarm-masking versions of DIMOS have been analysed in their ability to support Situation Awareness, to improve performance and to fulfil the satisfaction of operators. Both normal power plant operating conditions and abnormal operating conditions were simulated and a large number of power plant operators were involved in the evaluation. The paper focuses on the rationale behind the 'Situation Awareness' evaluation, the experiment environment and the results regarding the added value of the alarm masking version of the monitoring system. (author)

  20. Use of simulators for validation of advanced plant monitoring systems

    International Nuclear Information System (INIS)

    Uytterhoeven, G.; Vlaminck, M. De; Javaux, D.

    1999-01-01

    This paper describes how the full-scope nuclear power plant simulator of Doel (Belgium) was used to assess Situation Awareness for the validation of a process monitoring and supervision system, named DIMOS. The method (derived from a method originally developed for the aerospace industry) has been adapted and applied to compare the efficiency of two versions of the monitoring system: Alarm-masking and non alarm-masking versions of DIMOS have been analysed in their ability to support Situation Awareness, to improve performance and to fulfil the satisfaction of operators. Both normal power plant operating conditions and abnormal operating conditions were simulated and a large number of power plant operators were involved in the evaluation. The paper focuses on the rationale behind the 'Situation Awareness' evaluation, the experiment environment and the results regarding the added value of the alarm masking version of the monitoring system. (author)

  1. SU-F-J-193: Efficient Dose Extinction Method for Water Equivalent Path Length (WEPL) of Real Tissue Samples for Validation of CT HU to Stopping Power Conversion

    International Nuclear Information System (INIS)

    Zhang, R; Baer, E; Jee, K; Sharp, G; Flanz, J; Lu, H

    2016-01-01

    Purpose: For proton therapy, an accurate model of CT HU to relative stopping power (RSP) conversion is essential. In current practice, validation of these models relies solely on measurements of tissue substitutes with standard compositions. Validation based on real tissue samples would be much more direct and can address variations between patients. This study intends to develop an efficient and accurate system based on the concept of dose extinction to measure WEPL and retrieve RSP in biological tissue in large number of types. Methods: A broad AP proton beam delivering a spread out Bragg peak (SOBP) is used to irradiate the samples with a Matrixx detector positioned immediately below. A water tank was placed on top of the samples, with the water level controllable in sub-millimeter by a remotely controlled dosing pump. While gradually lowering the water level with beam on, the transmission dose was recorded at 1 frame/sec. The WEPL were determined as the difference between the known beam range of the delivered SOBP (80%) and the water level corresponding to 80% of measured dose profiles in time. A Gammex 467 phantom was used to test the system and various types of biological tissue was measured. Results: RSP for all Gammex inserts, expect the one made with lung-450 material (<2% error), were determined within ±0.5% error. Depends on the WEPL of investigated phantom, a measurement takes around 10 min, which can be accelerated by a faster pump. Conclusion: Based on the concept of dose extinction, a system was explored to measure WEPL efficiently and accurately for a large number of samples. This allows the validation of CT HU to stopping power conversions based on large number of samples and real tissues. It also allows the assessment of beam uncertainties due to variations over patients, which issue has never been sufficiently studied before.

  2. SU-F-J-193: Efficient Dose Extinction Method for Water Equivalent Path Length (WEPL) of Real Tissue Samples for Validation of CT HU to Stopping Power Conversion

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, R; Baer, E; Jee, K; Sharp, G; Flanz, J; Lu, H [Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States)

    2016-06-15

    Purpose: For proton therapy, an accurate model of CT HU to relative stopping power (RSP) conversion is essential. In current practice, validation of these models relies solely on measurements of tissue substitutes with standard compositions. Validation based on real tissue samples would be much more direct and can address variations between patients. This study intends to develop an efficient and accurate system based on the concept of dose extinction to measure WEPL and retrieve RSP in biological tissue in large number of types. Methods: A broad AP proton beam delivering a spread out Bragg peak (SOBP) is used to irradiate the samples with a Matrixx detector positioned immediately below. A water tank was placed on top of the samples, with the water level controllable in sub-millimeter by a remotely controlled dosing pump. While gradually lowering the water level with beam on, the transmission dose was recorded at 1 frame/sec. The WEPL were determined as the difference between the known beam range of the delivered SOBP (80%) and the water level corresponding to 80% of measured dose profiles in time. A Gammex 467 phantom was used to test the system and various types of biological tissue was measured. Results: RSP for all Gammex inserts, expect the one made with lung-450 material (<2% error), were determined within ±0.5% error. Depends on the WEPL of investigated phantom, a measurement takes around 10 min, which can be accelerated by a faster pump. Conclusion: Based on the concept of dose extinction, a system was explored to measure WEPL efficiently and accurately for a large number of samples. This allows the validation of CT HU to stopping power conversions based on large number of samples and real tissues. It also allows the assessment of beam uncertainties due to variations over patients, which issue has never been sufficiently studied before.

  3. Modeling and validation of existing VAV system components

    Energy Technology Data Exchange (ETDEWEB)

    Nassif, N.; Kajl, S.; Sabourin, R. [Ecole de Technologie Superieure, Montreal, PQ (Canada)

    2004-07-01

    The optimization of supervisory control strategies and local-loop controllers can improve the performance of HVAC (heating, ventilating, air-conditioning) systems. In this study, the component model of the fan, the damper and the cooling coil were developed and validated against monitored data of an existing variable air volume (VAV) system installed at Montreal's Ecole de Technologie Superieure. The measured variables that influence energy use in individual HVAC models included: (1) outdoor and return air temperature and relative humidity, (2) supply air and water temperatures, (3) zone airflow rates, (4) supply duct, outlet fan, mixing plenum static pressures, (5) fan speed, and (6) minimum and principal damper and cooling and heating coil valve positions. The additional variables that were considered, but not measured were: (1) fan and outdoor airflow rate, (2) inlet and outlet cooling coil relative humidity, and (3) liquid flow rate through the heating or cooling coils. The paper demonstrates the challenges of the validation process when monitored data of existing VAV systems are used. 7 refs., 11 figs.

  4. Statistically validated network of portfolio overlaps and systemic risk.

    Science.gov (United States)

    Gualdi, Stanislao; Cimini, Giulio; Primicerio, Kevin; Di Clemente, Riccardo; Challet, Damien

    2016-12-21

    Common asset holding by financial institutions (portfolio overlap) is nowadays regarded as an important channel for financial contagion with the potential to trigger fire sales and severe losses at the systemic level. We propose a method to assess the statistical significance of the overlap between heterogeneously diversified portfolios, which we use to build a validated network of financial institutions where links indicate potential contagion channels. The method is implemented on a historical database of institutional holdings ranging from 1999 to the end of 2013, but can be applied to any bipartite network. We find that the proportion of validated links (i.e. of significant overlaps) increased steadily before the 2007-2008 financial crisis and reached a maximum when the crisis occurred. We argue that the nature of this measure implies that systemic risk from fire sales liquidation was maximal at that time. After a sharp drop in 2008, systemic risk resumed its growth in 2009, with a notable acceleration in 2013. We finally show that market trends tend to be amplified in the portfolios identified by the algorithm, such that it is possible to have an informative signal about institutions that are about to suffer (enjoy) the most significant losses (gains).

  5. May 2011 Groundwater and Surface Water Sampling at the Rio Blanco, Colorado, Site (Data Validation Package)

    International Nuclear Information System (INIS)

    2011-01-01

    Annual sampling was conducted at the Rio Blanco, Colorado, site for the Long-Term Hydrologic Monitoring Program May 16-17, 2011, to monitor groundwater and surface water for potential radionuclide contamination. Sampling and analyses were conducted as specified in Sampling and Analysis Plan for the U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location Johnson Artesian WL. Samples were analyzed by the U.S. Environmental Protection Agency (EPA) Radiation&Indoor Environments National Laboratory in Las Vegas, Nevada. Samples were analyzed for gamma-emitting radionuclides by high-resolution gamma spectrometry, and for tritium using the conventional method. Tritium was not measured using the enrichment method because the EPA laboratory no longer offers that service. Results of this monitoring at the Rio Blanco site demonstrate that groundwater and surface water outside the boundaries have not been affected by project-related contaminants.

  6. Design and validation of a questionnaire to evaluate the usability of computerized critical care information systems.

    Science.gov (United States)

    von Dincklage, Falk; Lichtner, Gregor; Suchodolski, Klaudiusz; Ragaller, Maximilian; Friesdorf, Wolfgang; Podtschaske, Beatrice

    2017-08-01

    The implementation of computerized critical care information systems (CCIS) can improve the quality of clinical care and staff satisfaction, but also holds risks of disrupting the workflow with consecutive negative impacts. The usability of CCIS is one of the key factors determining their benefits and weaknesses. However, no tailored instrument exists to measure the usability of such systems. Therefore, the aim of this study was to design and validate a questionnaire that measures the usability of CCIS. Following a mixed-method design approach, we developed a questionnaire comprising two evaluation models to assess the usability of CCIS: (1) the task-specific model rates the usability individually for several tasks which CCIS could support and which we derived by analyzing work processes in the ICU; (2) the characteristic-specific model rates the different aspects of the usability, as defined by the international standard "ergonomics of human-system interaction". We tested validity and reliability of the digital version of the questionnaire in a sample population. In the sample population of 535 participants both usability evaluation models showed a strong correlation with the overall rating of the system (multiple correlation coefficients ≥0.80) as well as a very high internal consistency (Cronbach's alpha ≥0.93). The novel questionnaire is a valid and reliable instrument to measure the usability of CCIS and can be used to study the influence of the usability on their implementation benefits and weaknesses.

  7. Validation of {sup 226}Ra, {sup 228}Ra and {sup 210}Pb measurements in soil and sediment samples through high resolution gamma ray spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Danila Carrijo da Silva; Silva, Nivaldo Carlos da; Bonifacio, Rodrigo Leandro; Guerrero, Eder Tadeu Zenun [Comissao Nacional de Energia Nuclear (LAPOC/CNEN-MG), Pocos de Caldas, MG (Brazil). Laboratorio de Pocos de Caldas

    2013-07-01

    Radionuclides found in ore extraction waste materials are a great source of concern regarding public health and environmental safety. One technique to determine the concentration of substances is high resolution gamma ray spectrometry using HPGe. Validating a measurement technique is essential to warrant high levels of quality to any scientific work. The Laboratory of Pocos de Caldas of the Brazilian Commission for Nuclear Energy partakes into a Quality Management System project, seeking Accreditation under ISO/IEC 17025 through the validation of techniques of chemical and radiometric analysis of environmental samples from water, soil and sediment. The focus of the Radon Laboratory at LAPOC is validation of Ra-226, Ra-228 and Pb-210 concentration determinations in soil and sediment through a gamma spectrometer system. The stages of this validation process included sample reception and preparation, detector calibration and sample analyses. Dried samples were sealed in metallic containers and analyzed after radioactive equilibrium between Ra-226 and daughters Pb-214 and Bi-214. Gamma spectrometry was performed using CANBERRA HPGe detector and gamma spectrum software Genie 2000. The photo peaks used for Ra-226 determination were 609 keV and 1020 keV of Bi-214 and 351 keV of Pb-214. For the Ra-228 determination a photopeak of 911 keV was used from its short half-life daughter Ac-228 (T1/2 = 6.12 h). For Pb-210, the photopeak of 46.5 keV was used, which, due to the low energy, self-absorption correction was needed. Parameters such as precision, bias/accuracy, linearity, detection limit and uncertainty were evaluated for that purpose. The results have pointed to satisfying results. (author)

  8. Validation of 226Ra, 228Ra and 210Pb measurements in soil and sediment samples through high resolution gamma ray spectrometry

    International Nuclear Information System (INIS)

    Dias, Danila Carrijo da Silva; Silva, Nivaldo Carlos da; Bonifacio, Rodrigo Leandro; Guerrero, Eder Tadeu Zenun

    2013-01-01

    Radionuclides found in ore extraction waste materials are a great source of concern regarding public health and environmental safety. One technique to determine the concentration of substances is high resolution gamma ray spectrometry using HPGe. Validating a measurement technique is essential to warrant high levels of quality to any scientific work. The Laboratory of Pocos de Caldas of the Brazilian Commission for Nuclear Energy partakes into a Quality Management System project, seeking Accreditation under ISO/IEC 17025 through the validation of techniques of chemical and radiometric analysis of environmental samples from water, soil and sediment. The focus of the Radon Laboratory at LAPOC is validation of Ra-226, Ra-228 and Pb-210 concentration determinations in soil and sediment through a gamma spectrometer system. The stages of this validation process included sample reception and preparation, detector calibration and sample analyses. Dried samples were sealed in metallic containers and analyzed after radioactive equilibrium between Ra-226 and daughters Pb-214 and Bi-214. Gamma spectrometry was performed using CANBERRA HPGe detector and gamma spectrum software Genie 2000. The photo peaks used for Ra-226 determination were 609 keV and 1020 keV of Bi-214 and 351 keV of Pb-214. For the Ra-228 determination a photopeak of 911 keV was used from its short half-life daughter Ac-228 (T1/2 = 6.12 h). For Pb-210, the photopeak of 46.5 keV was used, which, due to the low energy, self-absorption correction was needed. Parameters such as precision, bias/accuracy, linearity, detection limit and uncertainty were evaluated for that purpose. The results have pointed to satisfying results. (author)

  9. New Empirical Evidence on the Validity and the Reliability of the Early Life Stress Questionnaire in a Polish Sample.

    Science.gov (United States)

    Sokołowski, Andrzej; Dragan, Wojciech Ł

    2017-01-01

    Background: The Early Life Stress Questionnaire (ELSQ) is widely used to estimate the prevalence of negative events during childhood, including emotional, physical, verbal, sexual abuse, negligence, severe conflicts, separation, parental divorce, substance abuse, poverty, and so forth. Objective: This study presents the psychometric properties of the Polish adaptation of the ELSQ. It also verifies if early life stress (ELS) is a good predictor of psychopathology symptoms during adulthood. Materials and Methods: We analyzed data from two samples. Sample 1 was selected by random quota method from across the country and included 609 participants aged 18-50 years, 306 women (50.2%) and 303 men (49.8%). Sample 2 contained 503 young adults (253 women and 250 men) aged 18-25. Confirmatory and exploratory factor analyses were used to measure ELSQ internal consistency. The validity was based on the relation to psychopathological symptoms and substance misuse. Results: Results showed good internal consistency and validity. Exploratory factor analysis indicates a six-factor structure of the ELSQ. ELS was related to psychopathology in adulthood, including depressive, sociophobic, vegetative as well as pain symptoms. ELSQ score correlated also with alcohol use, but not nicotine dependence. Moreover, ELS was correlated with stress in adulthood. Conclusion: The findings indicate that the Polish version of the ELSQ is a valid and reliable instrument for assessing ELS in the Polish population and may be applied in both clinical and community samples.

  10. Validation of Passive Sampling Devices for Monitoring of Munitions Constituents in Underwater Environments

    Science.gov (United States)

    2017-09-01

    and sampling handling was met. All calibration criteria and instrument maintenance was met for all final reported data. 23 3.2 QUALITATIVE ...the relatively large size of each sampling box within the grid, there were no issues associated with locating appropriate anchoring locations, based...quantiative, as only estimated sampling rates were available, or spiked recoveries were lower suggesting the results are qualitative . TNT RDX ADNTs

  11. Evolution of the JPSS Ground Project Calibration and Validation System

    Science.gov (United States)

    Purcell, Patrick; Chander, Gyanesh; Jain, Peyush

    2016-01-01

    The Joint Polar Satellite System (JPSS) is the National Oceanic and Atmospheric Administration's (NOAA) next-generation operational Earth observation Program that acquires and distributes global environmental data from multiple polar-orbiting satellites. The JPSS Program plays a critical role to NOAA's mission to understand and predict changes in weather, climate, oceans, coasts, and space environments, which supports the Nation's economy and protection of lives and property. The National Aeronautics and Space Administration (NASA) is acquiring and implementing the JPSS, comprised of flight and ground systems, on behalf of NOAA. The JPSS satellites are planned to fly in the afternoon orbit and will provide operational continuity of satellite-based observations and products for NOAA Polar-orbiting Operational Environmental Satellites (POES) and the Suomi National Polar-orbiting Partnership (SNPP) satellite. To support the JPSS Calibration and Validation (CalVal) node Government Resource for Algorithm Verification, Independent Test, and Evaluation (GRAVITE) services facilitate: Algorithm Integration and Checkout, Algorithm and Product Operational Tuning, Instrument Calibration, Product Validation, Algorithm Investigation, and Data Quality Support and Monitoring. GRAVITE is a mature, deployed system that currently supports the SNPP Mission and has been in operations since SNPP launch. This paper discusses the major re-architecture for Block 2.0 that incorporates SNPP lessons learned, architecture of the system, and demonstrates how GRAVITE has evolved as a system with increased performance. It is now a robust, stable, reliable, maintainable, scalable, and secure system that supports development, test, and production strings, replaces proprietary and custom software, uses open source software, and is compliant with NASA and NOAA standards.

  12. Data Validation Package, June 2016 Groundwater Sampling at the Hallam, Nebraska, Decommissioned Reactor Site, August 2016

    Energy Technology Data Exchange (ETDEWEB)

    Surovchak, Scott [USDOE Office of Legacy Management, Washington, DC (United States); Miller, Michele [Navarro Research and Engineering, Oak Ridge, TN (United States)

    2016-08-01

    The 2008 Long-Term Surveillance Plan [LTSP] for the Decommissioned Hallam Nuclear Power Facility, Hallam, Nebraska (http://www.lm.doe.gov/Hallam/Documents.aspx) requires groundwater monitoring once every 2 years. Seventeen monitoring wells at the Hallam site were sampled during this event as specified in the plan. Planned monitoring locations are shown in Attachment 1, Sampling and Analysis Work Order. Water levels were measured at all sampled wells and at two additional wells (6A and 6B) prior to the start of sampling. Additionally, water levels of each sampled well were measured at the beginning of sampling. See Attachment 2, Trip Report, for additional details. Sampling and analysis were conducted as specified in Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated, http://energy.gov/lm/downloads/sampling-and-analysis-plan-us-department- energy-office-legacy-management-sites). Gross alpha and gross beta are the only parameters that were detected at statistically significant concentrations. Time/concentration graphs of the gross alpha and gross beta data are included in Attachment 3, Data Presentation. The gross alpha and gross beta activity concentrations observed are consistent with values previously observed and are attributed to naturally occurring radionuclides (e.g., uranium and uranium decay chain products) in the groundwater.

  13. Expanding the Nomological Net of the Pathological Narcissism Inventory: German Validation and Extension in a Clinical Inpatient Sample.

    Science.gov (United States)

    Morf, Carolyn C; Schürch, Eva; Küfner, Albrecht; Siegrist, Philip; Vater, Aline; Back, Mitja; Mestel, Robert; Schröder-Abé, Michela

    2017-06-01

    The Pathological Narcissism Inventory (PNI) is a multidimensional measure for assessing grandiose and vulnerable features in narcissistic pathology. The aim of the present research was to construct and validate a German translation of the PNI and to provide further information on the PNI's nomological net. Findings from a first study confirm the psychometric soundness of the PNI and replicate its seven-factor first-order structure. A second-order structure was also supported but with several equivalent models. A second study investigating associations with a broad range of measures ( DSM Axis I and II constructs, emotions, personality traits, interpersonal and dysfunctional behaviors, and well-being) supported the concurrent validity of the PNI. Discriminant validity with the Narcissistic Personality Inventory was also shown. Finally, in a third study an extension in a clinical inpatient sample provided further evidence that the PNI is a useful tool to assess the more pathological end of narcissism.

  14. The Brief Multidimensional Students' Life Satisfaction Scale (BMSLSS): Reliability, validity, and gender invariance in an Indian adolescent sample.

    Science.gov (United States)

    Hashim, Jayana; Areepattamannil, Shaljan

    2017-06-01

    This study examined the internal consistency reliability, factorial, convergent, discriminant, and predictive validity, as well as gender invariance of the Brief Multidimensional Students' Life Satisfaction Scale (BMSLSS; Seligson, Huebner, & Valois, 2003) in a sample of 445 adolescents (M age  = 16.04 years) hailing from the southernmost state of India, Kerala. The study also examined the test-retest reliability (n = 392) of the BMSLSS. The Cronbach's alpha coefficient suggested that the BMSLSS was reliable. Confirmatory factor analyses demonstrated the factorial validity of the BMSLSS. Bivariate correlational analyses provided support for the convergent, discriminant, and predictive validity of the BMSLSS. The test-retest reliability coefficient indicated the temporal stability of the BMSLSS. Finally, multi-group confirmatory factor analysis provided support for the gender invariance of the BMSLSS. Copyright © 2017 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  15. Sample-hold and analog multiplexer for multidetector systems

    Energy Technology Data Exchange (ETDEWEB)

    Goswami, G C; Ghoshdostidar, M R; Ghosh, B; Chaudhuri, N [North Bengal Univ., Darjeeling (India). Dept. of Physics

    1982-08-15

    A new sample-hold circuit with an analog multiplexer system is described. Designed for multichannel acquistion of data from an air shower array, the system is being used for accurate measurements of pulse heights from 16 channels by the use of a single ADC.

  16. Chemical and Metallurgy Research (CMR) Sample Tracking System Design Document

    International Nuclear Information System (INIS)

    Bargelski, C. J.; Berrett, D. E.

    1998-01-01

    The purpose of this document is to describe the system architecture of the Chemical and Metallurgy Research (CMR) Sample Tracking System at Los Alamos National Laboratory. During the course of the document observations are made concerning the objectives, constraints and limitations, technical approaches, and the technical deliverables

  17. Fault tolerant controllers for sampled-data systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik; Stoustrup, Jakob

    2004-01-01

    A general compensator architecture for fault tolerant control (FTC) for sampled-data systems is proposed. The architecture is based on the YJBK parameterization of all stabilizing controllers, and uses the dual YJBK parameterization to quantify the performance of the fault tolerant system. The FTC...

  18. An Automated Sample Processing System for Planetary Exploration

    Science.gov (United States)

    Soto, Juancarlos; Lasnik, James; Roark, Shane; Beegle, Luther

    2012-01-01

    An Automated Sample Processing System (ASPS) for wet chemistry processing of organic materials on the surface of Mars has been jointly developed by Ball Aerospace and the Jet Propulsion Laboratory. The mechanism has been built and tested to demonstrate TRL level 4. This paper describes the function of the system, mechanism design, lessons learned, and several challenges that were overcome.

  19. Validation of the Basic Psychological Needs in Exercise Scale in a Portuguese sample.

    Science.gov (United States)

    Moutão, João Miguel Raimundo Peres; Serra, Luis Filipe Cid; Alves, José Augusto Marinho; Leitão, José Carlos; Vlachopoulos, Symeon P

    2012-03-01

    In line with self-determination theory (SDT: Deci & Ryan, 1985, 2002) the satisfaction of the basic psychological needs for autonomy, competence, and relatedness has been identified as an important predictor of behavior and optimal functioning in various contexts including exercise. The lack of a valid and reliable instrument to assess the extent to which these needs are fulfilled among Portuguese exercise participants limits the evaluation of causal links proposed by SDT in the Portuguese exercise context. The aim of the present study was to translate into Portuguese and validate the Basic Psychological Needs in Exercise Scale (BPNES: Vlachopoulos & Michailidou, 2006). Using data from 522 exercise participants the findings provided evidence of strong internal consistency of the translated BPNES subscales while confirmatory factor analysis supported a good fit of the correlated 3-factor model to the data. The present findings support the use of the translated into Portuguese BPNES to assess the extent of basic psychological need fulfilment among Portuguese exercise participants.

  20. Factorial Validation of Malaysian Adapted Brunel Mood Scale in an Adolescent Sample

    OpenAIRE

    Hashim, Hairul Anuar; Zulkifli, Erie Zuraidee; Yusof @ Hanafi, Hazwani Ahmad

    2010-01-01

    Purpose The present study investigated the psychometric properties of a Malaysian adapted Brunel Mood Scale. Methods The questionnaire was administered to 355 young sport athletes with a mean age of 14.69+1.70 years. Confirmatory factor analysis (CFA) and Cronbach's alpha were used to determine the factorial validity and the internal consistency of the questionnaire respectively. Results CFA results revealed adequate model fit, best represented by a 6-factor model with one of the items remove...

  1. Reliability, convergent validity and factor structure of the DASS-21 in a sample of Vietnamese adolescents.

    Science.gov (United States)

    Le, Minh Thi Hong; Tran, Thach Duc; Holton, Sara; Nguyen, Huong Thanh; Wolfe, Rory; Fisher, Jane

    2017-01-01

    To assess the internal consistency, latent structure and convergent validity of the Depression, Anxiety and Stress Scale-21 (DASS-21) among adolescents in Vietnam. An anonymous, self-completed questionnaire was conducted among 1,745 high school students in Hanoi, Vietnam between October, 2013 and January, 2014. Confirmatory factor analyses were performed to assess the latent structure of the DASS-21. Factorial invariance between girls and boys was examined. Cronbach alphas and correlation coefficients between DASS-21 factor scores and the domain scores of the Duke Health Profile Adolescent Vietnamese validated version (ADHP-V) were calculated to assess DASS-21 internal consistency and convergent validity. A total of 1,606/ 1,745 (92.6%) students returned the questionnaire. Of those, 1,387 students provided complete DASS-21 data. The scale demonstrated adequate internal consistency (Cronbach α: 0.761 to 0.906). A four-factor model showed the best fit to the data. Items loaded significantly on a common general distress factor, the depression, and the anxiety factors, but few on the stress factor (pDASS-21 convergent validity was confirmed with moderate correlation coefficients (-0.47 to -0.66) between its factor scores and the ADHP-V mental health related domains. The DASS-21 is reliable and suitable for use to assess symptoms of common mental health problems, especially depression and anxiety among Vietnamese adolescents. However, its ability in detecting stress among these adolescents may be limited. Further research is warrant to explore these results.

  2. Reliability, convergent validity and factor structure of the DASS-21 in a sample of Vietnamese adolescents.

    Directory of Open Access Journals (Sweden)

    Minh Thi Hong Le

    Full Text Available To assess the internal consistency, latent structure and convergent validity of the Depression, Anxiety and Stress Scale-21 (DASS-21 among adolescents in Vietnam.An anonymous, self-completed questionnaire was conducted among 1,745 high school students in Hanoi, Vietnam between October, 2013 and January, 2014. Confirmatory factor analyses were performed to assess the latent structure of the DASS-21. Factorial invariance between girls and boys was examined. Cronbach alphas and correlation coefficients between DASS-21 factor scores and the domain scores of the Duke Health Profile Adolescent Vietnamese validated version (ADHP-V were calculated to assess DASS-21 internal consistency and convergent validity.A total of 1,606/ 1,745 (92.6% students returned the questionnaire. Of those, 1,387 students provided complete DASS-21 data. The scale demonstrated adequate internal consistency (Cronbach α: 0.761 to 0.906. A four-factor model showed the best fit to the data. Items loaded significantly on a common general distress factor, the depression, and the anxiety factors, but few on the stress factor (p<0.05. DASS-21 convergent validity was confirmed with moderate correlation coefficients (-0.47 to -0.66 between its factor scores and the ADHP-V mental health related domains.The DASS-21 is reliable and suitable for use to assess symptoms of common mental health problems, especially depression and anxiety among Vietnamese adolescents. However, its ability in detecting stress among these adolescents may be limited. Further research is warrant to explore these results.

  3. Data Validation Package: April 2016 Groundwater Sampling at the Falls City, Texas, Disposal Site

    Energy Technology Data Exchange (ETDEWEB)

    Jasso, Tashina [USDOE Office of Legacy Management, Washington, DC (United States); Widdop, Michael [Navarro Research and Engineering, Inc., Las Vegas, NV (United States)

    2016-09-29

    Nine groundwater samples were collected at the Falls City, Texas, Disposal Site as specified in the March 2008 Long-Term Surveillance Plan for the US Department of Energy Falls City Uranium Mill Tailings Disposal Site, Falls City, Texas (DOE-LM/1602-2008). Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for US Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). The wells sampled included the cell performance monitoring wells (0709, 0858, 0880, 0906, and 0921) and the groundwater monitoring wells (0862, 0886, 0891, 0924, and 0963). A duplicate sample was collected from location 0891. Water levels were measured at each sampled well. Historically, cell performance monitoring wells 0908 and 0916 have not produced water and were confirmed as dry during this sampling event. These wells are completed above the saturated interval in the formation. Notable observations for time-concentration graphs in this report include: (1) uranium concentrations in well 0891 continue to increase; (2) the uranium concentration in well 0880 is higher than the 2015 value and lower than the 2014 value, and it remains within the range of historical values; and (3) uranium concentrations in the other sampled wells are below 2 mg/L and consistent with previous results.

  4. Validity of pipelle endometrial sampling in the patients with abnormaluterine bleeding

    International Nuclear Information System (INIS)

    Fakhar, S.; Saeed, G.; Khan, A.H.; Alam, A.Y.

    2008-01-01

    We compared endometrial sampling by pipelle endometrial curette withconventional dilatation and curettage (D and C) in patients with abnormaluterine bleeding. Endometrial sampling with pipelle curette was performed on100 patients followed by formal D and C. Samples were labeled as A and B,respectively, and sent to a histopathologist who was blinded as to the methodof sampling. The histopathology reports of both samples were compared, takingD and C as the gold standard. An adequate sample was obtained in 98% of casesby pipelle and in 100% of cases by D and C. Pipelle had sensitivity,specificity, positive predictive value of 100% for diagnosing endometrialcarcinoma, hyperplasia and secretory endometrium. Pipelle also had highdiagnostic sensitivity, specificity and negative predictive value (100%, 98%and 100%, respectively) for hyperplasia with atypia and low sensitivity (57%)and positive predictive value (57%), but high specificity (97%) and negativepredictive value (97%) for endometritis. Similarly, for proliferativeendometrium, the pipelle technique had values of 94% and 93% for sensitivityand specificity, respectively. Both samples labeled as inadequate forhistology by pipelle were polyps on the D and C report. Difficultendotracheal intubation was encountered in two cases of D and C. No othercomplications of the procedure were observed. The pipelle is a safe devicefor getting an adequate endometrial sample for histology, with a highsensitivity and specificity for detection of hyperplasia and malignancy.(author)

  5. Validating the Factor Structure of the Self-Report Psychopathy Scale in a Community Sample

    Science.gov (United States)

    Mahmut, Mehmet K.; Menictas, Con; Stevenson, Richard J.; Homewood, Judi

    2011-01-01

    Currently, there is no standard self-report measure of psychopathy in community-dwelling samples that parallels the most commonly used measure of psychopathy in forensic and clinical samples, the Psychopathy Checklist. A promising instrument is the Self-Report Psychopathy scale (SRP), which was derived from the original version the Psychopathy…

  6. Data Validation Package May 2016 Groundwater Sampling at the Lakeview, Oregon, Processing Site August 2016

    Energy Technology Data Exchange (ETDEWEB)

    Linard, Joshua [USDOE Office of Legacy Management, Washington, DC (United States); Hall, Steve [Navarro Research and Engineering, Inc., Oak Ridge, TN (United States)

    2016-08-01

    This biennial event includes sampling five groundwater locations (four monitoring wells and one domestic well) at the Lakeview, Oregon, Processing Site. For this event, the domestic well (location 0543) could not be sampled because no one was in residence during the sampling event (Note: notification was provided to the resident prior to the event). Per Appendix A of the Groundwater Compliance Action Plan, sampling is conducted to monitor groundwater quality on a voluntary basis. Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). One duplicate sample was collected from location 0505. Water levels were measured at each sampled monitoring well. The constituents monitored at the Lakeview site are manganese and sulfate. Monitoring locations that exceeded the U.S. Environmental Protection Agency (EPA) Secondary Maximum Contaminant Levels for these constituents are listed in Table 1. Review of time-concentration graphs included in this report indicate that manganese and sulfate concentrations are consistent with historical measurements.

  7. Method validation for control determination of mercury in fresh fish and shrimp samples by solid sampling thermal decomposition/amalgamation atomic absorption spectrometry.

    Science.gov (United States)

    Torres, Daiane Placido; Martins-Teixeira, Maristela Braga; Cadore, Solange; Queiroz, Helena Müller

    2015-01-01

    A method for the determination of total mercury in fresh fish and shrimp samples by solid sampling thermal decomposition/amalgamation atomic absorption spectrometry (TDA AAS) has been validated following international foodstuff protocols in order to fulfill the Brazilian National Residue Control Plan. The experimental parameters have been previously studied and optimized according to specific legislation on validation and inorganic contaminants in foodstuff. Linearity, sensitivity, specificity, detection and quantification limits, precision (repeatability and within-laboratory reproducibility), robustness as well as accuracy of the method have been evaluated. Linearity of response was satisfactory for the two range concentrations available on the TDA AAS equipment, between approximately 25.0 and 200.0 μg kg(-1) (square regression) and 250.0 and 2000.0 μg kg(-1) (linear regression) of mercury. The residues for both ranges were homoscedastic and independent, with normal distribution. Correlation coefficients obtained for these ranges were higher than 0.995. Limits of quantification (LOQ) and of detection of the method (LDM), based on signal standard deviation (SD) for a low-in-mercury sample, were 3.0 and 1.0 μg kg(-1), respectively. Repeatability of the method was better than 4%. Within-laboratory reproducibility achieved a relative SD better than 6%. Robustness of the current method was evaluated and pointed sample mass as a significant factor. Accuracy (assessed as the analyte recovery) was calculated on basis of the repeatability, and ranged from 89% to 99%. The obtained results showed the suitability of the present method for direct mercury measurement in fresh fish and shrimp samples and the importance of monitoring the analysis conditions for food control purposes. Additionally, the competence of this method was recognized by accreditation under the standard ISO/IEC 17025.

  8. May 2012 Groundwater and Surface Water Sampling at the Rio Blanco, Colorado, Site (Data Validation Package)

    International Nuclear Information System (INIS)

    2012-01-01

    Annual sampling was conducted at the Rio Blanco, Colorado, site for the Long-Term Hydrologic Monitoring Program May 9-10, 2012, to monitor groundwater and surface water for potential radionuclide contamination. Sampling and analyses were conducted as specified in Sampling and Analysis Plan for the U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location Johnson Artesian WL. Samples were analyzed for gamma-emitting radionuclides by high-resolution gamma spectrometry and for tritium using the conventional and enrichment methods. Results of this monitoring at the Rio Blanco site demonstrate that groundwater and surface water outside the site boundaries have not been affected by project-related contaminants.

  9. The reliability and validity of the Saliba Postural Classification System.

    Science.gov (United States)

    Collins, Cristiana Kahl; Johnson, Vicky Saliba; Godwin, Ellen M; Pappas, Evangelos

    2016-07-01

    To determine the reliability and validity of the Saliba Postural Classification System (SPCS). Two physical therapists classified pictures of 100 volunteer participants standing in their habitual posture for inter and intra-tester reliability. For validity, 54 participants stood on a force plate in a habitual and a corrected posture, while a vertical force was applied through the shoulders until the clinician felt a postural give. Data were extracted at the time the give was felt and at a time in the corrected posture that matched the peak vertical ground reaction force (VGRF) in the habitual posture. Inter-tester reliability demonstrated 75% agreement with a Kappa = 0.64 (95% CI = 0.524-0.756, SE = 0.059). Intra-tester reliability demonstrated 87% agreement with a Kappa = 0.8, (95% CI = 0.702-0.898, SE = 0.05) and 80% agreement with a Kappa = 0.706, (95% CI = 0.594-0818, SE = 0.057). The examiner applied a significantly higher (p < 0.001) peak vertical force in the corrected posture prior to a postural give when compared to the habitual posture. Within the corrected posture, the %VGRF was higher when the test was ongoing vs. when a postural give was felt (p < 0.001). The %VGRF was not different between the two postures when comparing the peaks (p = 0.214). The SPCS has substantial agreement for inter- and intra-tester reliability and is largely a valid postural classification system as determined by the larger vertical forces in the corrected postures. Further studies on the correlation between the SPCS and diagnostic classifications are indicated.

  10. Validity of CBCL-derived PTSD and dissociation scales: further evidence in a sample of neglected children and adolescents.

    Science.gov (United States)

    Milot, Tristan; Plamondon, André; Ethier, Louise S; Lemelin, Jean-Pascal; St-Laurent, Diane; Rousseau, Michel

    2013-05-01

    There is growing evidence that child neglect is an important risk factor for posttraumatic stress disorder (PTSD) and dissociation. Considering that the Child Behavior Checklist (CBCL) is a widely used measure, the possibility of using validated CBCL-derived trauma symptoms scales could be particularly useful to better understand how trauma symptoms develop among neglected children and adolescents. This study examined the factor structure of three CBCL-derived measures of PTSD and dissociation (namely, PTSD scale, Dissociation scale, and PTSD/Dissociation scale) in a sample of 239 neglected children and adolescents aged 6 to 18 years using the latest version of CBCL (CBCL 6-18). Evidence of convergent validity of these scales was also examined for participants aged 12 and under using two well-validated measures of PTSD and Dissociation: the Trauma Symptoms Checklist for Young Children and the Child Dissociation Checklist. Findings suggest that CBCL-derived measures of trauma symptoms, especially PTSD and Dissociations scales, may be of heuristic value in the study of trauma symptomatology in neglected samples. Factor structure and evidence of convergent validity were supported for these two scales. Results also provide further support to the well-established assumption that PTSD and dissociation are two related but different constructs.

  11. Reliability and validity of teacher-rated symptoms of oppositional defiant disorder and conduct disorder in a clinical sample.

    Science.gov (United States)

    Ise, Elena; Görtz-Dorten, Anja; Döpfner, Manfred

    2014-01-01

    It is recommended to use information from multiple informants when making diagnostic decisions concerning oppositional defiant disorder (ODD) and conduct disorder (CD). The purpose of this study was to investigate the reliability and validity of teacher-rated symptoms of ODD and CD in a clinical sample. The sample comprised 421 children (84% boys; 6-17 years) diagnosed with ODD, CD, and/or attention deficit hyperactivity disorder (ADHD). Teachers completed a standardized ODD/CD symptom rating scale and the Teacher Report Form (TRF). The reliability (internal consistency) of the symptom rating scale was high (α = 0.90). Convergent and divergent validity were demonstrated by substantial correlations with similar TRF syndrome scales and low-to-moderate correlations with dissimilar TRF scales. Discriminant validity was shown by the ability of the symptom rating scale to differentiate between children with ODD/CD and those with ADHD. Factorial validity was demonstrated by principal component analysis, which produced a two-factor solution that is largely consistent with the two-dimensional model of ODD and CD proposed by the Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV-TR, although some CD symptoms representing aggressive behavior loaded on the ODD dimension. These findings suggest that DSM-IV-TR-based teacher rating scales are useful instruments for assessing disruptive behavior problems in children and adolescents.

  12. Validation and uncertainty estimation of fast neutron activation analysis method for Cu, Fe, Al, Si elements in sediment samples

    International Nuclear Information System (INIS)

    Sunardi; Samin Prihatin

    2010-01-01

    Validation and uncertainty estimation of Fast Neutron Activation Analysis (FNAA) method for Cu, Fe, Al, Si elements in sediment samples has been conduced. The aim of the research is to confirm whether FNAA method is still matches to ISO/lEC 17025-2005 standard. The research covered the verification, performance, validation of FNM and uncertainty estimation. Standard of SRM 8704 and sediments were weighted for certain weight and irradiated with 14 MeV fast neutron and then counted using gamma spectrometry. The result of validation method for Cu, Fe, Al, Si element showed that the accuracy were in the range of 95.89-98.68 %, while the precision were in the range 1.13-2.29 %. The result of uncertainty estimation for Cu, Fe, Al, and Si were 2.67, 1.46, 1.71 and 1.20 % respectively. From this data, it can be concluded that the FNM method is still reliable and valid for element contents analysis in samples, because the accuracy is up to 95 % and the precision is under 5 %, while the uncertainty are relatively small and suitable for the range 95 % level of confidence where the uncertainty maximum is 5 %. (author)

  13. Psychological capital: Internal and external validity of the Psychological Capital Questionnaire (PCQ-24 on a South African sample

    Directory of Open Access Journals (Sweden)

    Gina Görgens-Ekermans

    2013-10-01

    Research purpose: The objectives of this study were to investigate the internal validity (construct and discriminant validity, reliability and external validity (relationship with theoretically relevant variables, namely stress, burnout and work engagement of the PCQ-24. Motivation for the study: Multiple studies have underscored the value of PsyCap within the workplace. In order to harness the full potential of the construct in the South African environment, sound measurement thereof, evidenced by a psychometrically sound instrument, is needed. Research design, approach and method: A cross-sectional survey design was used. The sample consisted of employees at managerial and non-managerial levels, from a medium-sized construction company in the Western Cape, South Africa. In addition to PsyCap, perceived stress, work-related burnout and work engagement were measured. Main findings: The results provided preliminary evidence of construct and discriminant validity, reliability and significant relations with external theoretically relevant variables. Practical/managerial implications: Researchers may confidently use the PCQ-24 to measure the construct of PsyCap and investigate relations with workplace outcomes in the South African environment, informing human relations practices. Contribution/value-add: Preliminary evidence of the psychometric properties of the PCQ-24, which measures the construct of PsyCap (consisting of hope, self-efficacy, resilience and optimism on a South African sample, was provided in this study.

  14. Developmental validation of the PowerPlex(®) Fusion 6C System.

    Science.gov (United States)

    Ensenberger, Martin G; Lenz, Kristy A; Matthies, Learden K; Hadinoto, Gregory M; Schienman, John E; Przech, Angela J; Morganti, Michael W; Renstrom, Daniel T; Baker, Victoria M; Gawrys, Kori M; Hoogendoorn, Marlijn; Steffen, Carolyn R; Martín, Pablo; Alonso, Antonio; Olson, Hope R; Sprecher, Cynthia J; Storts, Douglas R

    2016-03-01

    The PowerPlex(®) Fusion 6C System is a 27-locus, six-dye, multiplex that includes all markers in the expanded CODIS core loci and increases overlap with STR database standards throughout the world. Additionally, it contains two, rapidly mutating, Y-STRs and is capable of both casework and database workflows, including direct amplification. A multi-laboratory developmental validation study was performed on the PowerPlex(®) Fusion 6C System. Here, we report the results of that study which followed SWGDAM guidelines and includes data for: species specificity, sensitivity, stability, precision, reproducibility and repeatability, case-type samples, concordance, stutter, DNA mixtures, and PCR-based procedures. Where appropriate we report data from both extracted DNA samples and direct amplification samples from various substrates and collection devices. Samples from all studies were separated on both Applied Biosystems 3500 series and 6-dye capable 3130 series Genetic Analyzers and data is reported for each. Together, the data validate the design and demonstrate the performance of the PowerPlex(®) Fusion 6C System. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  15. Validation of the Postgraduate Hospital Educational Environment Measure (PHEEM) in a sample of 731 Greek residents.

    Science.gov (United States)

    Koutsogiannou, Persa; Dimoliatis, Ioannis D K; Mavridis, Dimitris; Bellos, Stefanos; Karathanos, Vassilis; Jelastopulu, Eleni

    2015-11-30

    The Greek version of the Postgraduate Hospital Educational Environment Measure (PHEEM) was evaluated to determine its psychometric properties, i.e., validity, internal consistency, sensitivity and responsiveness to be used for measuring the learning environment in Greek hospitals. The PHEEM was administered to Greek hospital residents. Internal consistency was measured using Cronbach's alpha. Root Mean Square Error of Approximation (RMSEA) was used to evaluate the fit of Structural Equation Models. Content validity was addressed by the original study. Construct validity was tested using confirmatory (to test the set of underlying dimensions suggested by the original study) and exploratory (to explore the dimensions needed to explain the variability of the given answers) factor analysis using Varimax rotation. Convergent validity was calculated by Pearson's correlation coefficient regarding the participant's PHEEM score and participant's overall satisfaction score of the added item "Overall, I am very satisfied with my specialization in this post". Sensitivity was checked by comparing good versus poor aspects of the educational environment and by satisfied versus unsatisfied participants. A total of 731 residents from 83 hospitals and 41 prefectures responded to the PHEEM. The original three-factor model didn't fit better compared to one factor model that is accounting for 32% of the variance. Cronbach's α was 0.933 when assuming one-factor model. Using a three-factor model (autonomy, teaching, social support), Cronbach's α were 0.815 (expected 0.830), 0.908 (0.839), 0.734 (0.793), respectively. The three-factor model gave an RMSEA value of 0.074 (90% confidence interval 0.071, 0.076), suggesting a fair fit. Pearson's correlation coefficient between total PHEEM and global satisfaction was 0.765. Mean question scores ranged from 19.0 (very poor) to 73.7 (very good), and mean participant scores from 5.5 (very unsatisfied) to 96.5 (very satisfied). The Greek version

  16. Demonstration Exercise of a Validated Sample Collection Method for Powders Suspected of Being Biological Agents in Georgia 2006

    International Nuclear Information System (INIS)

    Marsh, B.

    2007-01-01

    August 7, 2006 the state of Georgia conducted a collaborative sampling exercise between the Georgia National Guard 4th Civil Support Team Weapons of Mass Destruction (CST-WMD) and the Georgia Department of Human Resources Division of Public Health demonstrating a recently validated bulk powder sampling method. The exercise was hosted at the Federal Law Enforcement Training Center (FLETC) at Glynn County, Georgia and involved the participation of the Georgia Emergency Management Agency (GEMA), Georgia National Guard, Georgia Public Health Laboratories, the Federal Bureau of Investigation Atlanta Office, Georgia Coastal Health District, and the Glynn County Fire Department. The purpose of the exercise was to demonstrate a recently validated national sampling standard developed by the American Standards and Test Measures (ASTM) International; ASTM E2458 S tandard Practice for Bulk Sample Collection and Swab Sample Collection of Visible Powders Suspected of Being Biological Agents from Nonporous Surfaces . The intent of the exercise was not to endorse the sampling method, but to develop a model for exercising new sampling methods in the context of existing standard operating procedures (SOPs) while strengthening operational relationships between response teams and analytical laboratories. The exercise required a sampling team to respond real-time to an incident cross state involving a clandestine bio-terrorism production lab found within a recreational vehicle (RV). Sample targets consisted of non-viable gamma irradiated B. anthracis Sterne spores prepared by Dugway Proving Ground. Various spore concentration levels were collected by the ASTM method, followed by on- and off-scene analysis utilizing the Center for Disease Control (CDC) Laboratory Response Network (LRN) and National Guard Bureau (NGB) CST mobile Analytical Laboratory Suite (ALS) protocols. Analytical results were compared and detailed surveys of participant evaluation comments were examined. I will

  17. Validation of the Internet Gaming Disorder Scale - Short-Form (IGDS9-SF) in an Italian-speaking sample.

    Science.gov (United States)

    Monacis, Lucia; Palo, Valeria de; Griffiths, Mark D; Sinatra, Maria

    2016-12-01

    Background and aims The inclusion of Internet Gaming Disorder (IGD) in Section III of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders has increased the interest of researchers in the development of new standardized psychometric tools for the assessment of such a disorder. To date, the nine-item Internet Gaming Disorder Scale - Short-Form (IGDS9-SF) has only been validated in English, Portuguese, and Slovenian languages. Therefore, the aim of this investigation was to examine the psychometric properties of the IGDS9-SF in an Italian-speaking sample. Methods A total of 757 participants were recruited to the present study. Confirmatory factor analysis and multi-group analyses were applied to assess the construct validity. Reliability analyses comprised the average variance extracted, the standard error of measurement, and the factor determinacy coefficient. Convergent and criterion validities were established through the associations with other related constructs. The receiver operating characteristic curve analysis was used to determine an empirical cut-off point. Results Findings confirmed the single-factor structure of the instrument, its measurement invariance at the configural level, and the convergent and criterion validities. Satisfactory levels of reliability and a cut-off point of 21 were obtained. Discussion and conclusions The present study provides validity evidence for the use of the Italian version of the IGDS9-SF and may foster research into gaming addiction in the Italian context.

  18. Validation of the Internet Gaming Disorder Scale – Short-Form (IGDS9-SF) in an Italian-speaking sample

    Science.gov (United States)

    Monacis, Lucia; de Palo, Valeria; Griffiths, Mark D.; Sinatra, Maria

    2016-01-01

    Background and aims The inclusion of Internet Gaming Disorder (IGD) in Section III of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders has increased the interest of researchers in the development of new standardized psychometric tools for the assessment of such a disorder. To date, the nine-item Internet Gaming Disorder Scale – Short-Form (IGDS9-SF) has only been validated in English, Portuguese, and Slovenian languages. Therefore, the aim of this investigation was to examine the psychometric properties of the IGDS9-SF in an Italian-speaking sample. Methods A total of 757 participants were recruited to the present study. Confirmatory factor analysis and multi-group analyses were applied to assess the construct validity. Reliability analyses comprised the average variance extracted, the standard error of measurement, and the factor determinacy coefficient. Convergent and criterion validities were established through the associations with other related constructs. The receiver operating characteristic curve analysis was used to determine an empirical cut-off point. Results Findings confirmed the single-factor structure of the instrument, its measurement invariance at the configural level, and the convergent and criterion validities. Satisfactory levels of reliability and a cut-off point of 21 were obtained. Discussion and conclusions The present study provides validity evidence for the use of the Italian version of the IGDS9-SF and may foster research into gaming addiction in the Italian context. PMID:27876422

  19. Validated TRNSYS Model for Solar Assisted Space Heating System

    International Nuclear Information System (INIS)

    Abdalla, Nedal

    2014-01-01

    The present study involves a validated TRNSYS model for solar assisted space heating system as applied to a residential building in Jordan using new detailed radiation models of the TRNSYS 17.1 and geometric building model Trnsys3d for the Google SketchUp 3D drawing program. The annual heating load for a building (Solar House) which is located at the Royal ScientiFIc Society (RS5) in Jordan is estimated under climatological conditions of Amman. The aim of this Paper is to compare measured thermal performance of the Solar House with that modeled using TRNSYS. The results showed that the annual measured space heating load for the building was 6,188 kWh while the heati.ng load for the modeled building was 6,391 kWh. Moreover, the measured solar fraction for the solar system was 50% while the modeled solar fraction was 55%. A comparison of modeled and measured data resulted in percentage mean absolute errors for solar energy for space heating, auxiliary heating and solar fraction of 13%, 7% and 10%, respectively. The validated model will be useful for long-term performance simulation under different weather and operating conditions.(author)

  20. Sample Size for Tablet Compression and Capsule Filling Events During Process Validation.

    Science.gov (United States)

    Charoo, Naseem Ahmad; Durivage, Mark; Rahman, Ziyaur; Ayad, Mohamad Haitham

    2017-12-01

    During solid dosage form manufacturing, the uniformity of dosage units (UDU) is ensured by testing samples at 2 stages, that is, blend stage and tablet compression or capsule/powder filling stage. The aim of this work is to propose a sample size selection approach based on quality risk management principles for process performance qualification (PPQ) and continued process verification (CPV) stages by linking UDU to potential formulation and process risk factors. Bayes success run theorem appeared to be the most appropriate approach among various methods considered in this work for computing sample size for PPQ. The sample sizes for high-risk (reliability level of 99%), medium-risk (reliability level of 95%), and low-risk factors (reliability level of 90%) were estimated to be 299, 59, and 29, respectively. Risk-based assignment of reliability levels was supported by the fact that at low defect rate, the confidence to detect out-of-specification units would decrease which must be supplemented with an increase in sample size to enhance the confidence in estimation. Based on level of knowledge acquired during PPQ and the level of knowledge further required to comprehend process, sample size for CPV was calculated using Bayesian statistics to accomplish reduced sampling design for CPV. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  1. Validation of a Sampling Method to Collect Exposure Data for Central-Line-Associated Bloodstream Infections.

    Science.gov (United States)

    Hammami, Naïma; Mertens, Karl; Overholser, Rosanna; Goetghebeur, Els; Catry, Boudewijn; Lambert, Marie-Laurence

    2016-05-01

    Surveillance of central-line-associated bloodstream infections requires the labor-intensive counting of central-line days (CLDs). This workload could be reduced by sampling. Our objective was to evaluate the accuracy of various sampling strategies in the estimation of CLDs in intensive care units (ICUs) and to establish a set of rules to identify optimal sampling strategies depending on ICU characteristics. Analyses of existing data collected according to the European protocol for patient-based surveillance of ICU-acquired infections in Belgium between 2004 and 2012. CLD data were reported by 56 ICUs in 39 hospitals during 364 trimesters. We compared estimated CLD data obtained from weekly and monthly sampling schemes with the observed exhaustive CLD data over the trimester by assessing the CLD percentage error (ie, observed CLDs - estimated CLDs/observed CLDs). We identified predictors of improved accuracy using linear mixed models. When sampling once per week or 3 times per month, 80% of ICU trimesters had a CLD percentage error within 10%. When sampling twice per week, this was >90% of ICU trimesters. Sampling on Tuesdays provided the best estimations. In the linear mixed model, the observed CLD count was the best predictor for a smaller percentage error. The following sampling strategies provided an estimate within 10% of the actual CLD for 97% of the ICU trimesters with 90% confidence: 3 times per month in an ICU with >650 CLDs per trimester or each Tuesday in an ICU with >480 CLDs per trimester. Sampling of CLDs provides an acceptable alternative to daily collection of CLD data.

  2. ACS sampling system: design, implementation, and performance evaluation

    Science.gov (United States)

    Di Marcantonio, Paolo; Cirami, Roberto; Chiozzi, Gianluca

    2004-09-01

    By means of ACS (ALMA Common Software) framework we designed and implemented a sampling system which allows sampling of every Characteristic Component Property with a specific, user-defined, sustained frequency limited only by the hardware. Collected data are sent to various clients (one or more Java plotting widgets, a dedicated GUI or a COTS application) using the ACS/CORBA Notification Channel. The data transport is optimized: samples are cached locally and sent in packets with a lower and user-defined frequency to keep network load under control. Simultaneous sampling of the Properties of different Components is also possible. Together with the design and implementation issues we present the performance of the sampling system evaluated on two different platforms: on a VME based system using VxWorks RTOS (currently adopted by ALMA) and on a PC/104+ embedded platform using Red Hat 9 Linux operating system. The PC/104+ solution offers, as an alternative, a low cost PC compatible hardware environment with free and open operating system.

  3. Selenium isotope studies in plants. Development and validation of a novel geochemical tool and its application to organic samples

    Energy Technology Data Exchange (ETDEWEB)

    Banning, Helena

    2016-03-12

    Selenium (Se), being an essential nutrient and a toxin, enters the food chain mainly via plants. Selenium isotope signatures were proved to be an excellent redox tracer, making it a promising tool for the exploration of the Se cycle in plants. The analytical method is sensitive on organic samples and requires particular preparation methods, which were developed and validated in this study. Plant cultivation setups revealed the applicability of these methods to trace plant internal processes.

  4. June 2012 Groundwater Sampling at the Central Nevada Test Area (Data Validation Package)

    International Nuclear Information System (INIS)

    2013-01-01

    The U.S. Department of Energy Office of Legacy Management conducted annual sampling at the Central Nevada Test Area (CNTA) on June 26-27, 2012, in accordance with the 2004 Correction Action Decision Document/Corrective Action Plan for Corrective Action Unit 443: Central Nevada Test Area (CNTA)-Subsurface and the addendum to the 'Corrective Action Decision Document/Corrective Action Plan' completed in 2008. Sampling and analysis were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PLN/S04351), continually updated).

  5. May 2011 Groundwater Sampling at the Central Nevada Test Area (Data Validation Package)

    International Nuclear Information System (INIS)

    2011-01-01

    The U.S. Department of Energy Office of Legacy Management conducted annual sampling at the Central Nevada Test Area (CNTA) on May 10-11, 2011, in accordance with the 2004 Correction Action Decision Document/Corrective Action Plan for Corrective Action Unit 443: Central Nevada Test Area (CNTA)-Subsurface and the addendum to the 'Corrective Action Decision Document/Corrective Action Plan' completed in 2008. Sampling and analysis were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PLN/S04351), continually updated)

  6. Integrated Validation System for a Thermal-hydraulic System Code, TASS/SMR-S

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hee-Kyung; Kim, Hyungjun; Kim, Soo Hyoung; Hwang, Young-Dong [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Kim, Hyeon-Soo [Chungnam National University, Daejeon (Korea, Republic of)

    2015-10-15

    Development including enhancement and modification of thermal-hydraulic system computer code is indispensable to a new reactor, SMART. Usually, a thermal-hydraulic system code validation is achieved by a comparison with the results of corresponding physical effect tests. In the reactor safety field, a similar concept, referred to as separate effect tests has been used for a long time. But there are so many test data for comparison because a lot of separate effect tests and integral effect tests are required for a code validation. It is not easy to a code developer to validate a computer code whenever a code modification is occurred. IVS produces graphs which shown the comparison the code calculation results with the corresponding test results automatically. IVS was developed for a validation of TASS/SMR-S code. The code validation could be achieved by a comparison code calculation results with corresponding test results. This comparison was represented as a graph for convenience. IVS is useful before release a new code version. The code developer can validate code result easily using IVS. Even during code development, IVS could be used for validation of code modification. The code developer could gain a confidence about his code modification easily and fast and could be free from tedious and long validation work. The popular software introduced in IVS supplies better usability and portability.

  7. Application of verification and validation on safety parameter display systems

    International Nuclear Information System (INIS)

    Thomas, N.C.

    1983-01-01

    Offers some explanation of how verification and validation (VandV) can support development and licensing of the Safety Parameter Display Systems (SPDS). Advocates that VandV can be more readily accepted within the nuclear industry if a better understanding exists of what the objectives of VandV are and should be. Includes a discussion regarding a reasonable balance of costs and benefits of VandV as applied to the SPDS and to other digital systems. Represents the author's perception of the regulator's perspective based on background information and experience, and discussions with regulators about their current concerns and objectives. Suggests that the introduction of the SPDS into the Control Room is a first step towards growing dependency on use of computers

  8. Experimental Validation of the LHC Helium Relief System Flow Modeling

    CERN Document Server

    Fydrych, J; Riddone, G

    2006-01-01

    In case of simultaneous resistive transitions in a whole sector of magnets in the Large Hadron Collider, the helium would be vented from the cold masses to a dedicated recovery system. During the discharge the cold helium will eventually enter a pipe at room temperature. During the first period of the flow the helium will be heated intensely due to the pipe heat capacity. To study the changes of the helium thermodynamic and flow parameters we have simulated numerically the most critical flow cases. To verify and validate numerical results, a dedicated laboratory test rig representing the helium relief system has been designed and commissioned. Both numerical and experimental results allow us to determine the distributions of the helium parameters along the pipes as well as mechanical strains and stresses.

  9. Controlling a sample changer using the integrated counting system

    International Nuclear Information System (INIS)

    Deacon, S.; Stevens, M.P.

    1985-06-01

    Control of the Sample Changer from a counting system can be achieved by using a Scaler Timer type 6255 and Sample Changer Control Interface type 6263. The interface used, however, has quite complex circuitry. The application therefore lends itself to the use of another 6000 Series module the Integrated Counting System (ICS). Using this unit control is carried out through a control program written in BASIC for the Commodore PET (or any other device with an IEEE-488 interface). The ICS then controls the sample changer through an interface unit which is relatively simple. A brief description of how ICS controls the sample changer is given. The control program is then described, firstly the running options are given, followed by a program description listing and flowchart. (author)

  10. Controlling a sample changer using the integrated counting system

    Energy Technology Data Exchange (ETDEWEB)

    Deacon, S; Stevens, M P

    1985-06-01

    Control of the Sample Changer from a counting system can be achieved by using a Scaler Timer type 6255 and Sample Changer Control Interface type 6263. The interface used, however, has quite complex circuitry. The application therefore lends itself to the use of another 6000 Series module-the Integrated Counting System (ICS). Using this unit control is carried out through a control program written in BASIC for the Commodore PET (or any other device with an IEEE-488 interface). The ICS then controls the sample changer through an interface unit which is relatively simple. A brief description of how ICS controls the sample changer is given. The control program is then described; first the running options are given, followed by a program description listing and flowchart.

  11. Validation of the FAMACHA© system in South American camelids.

    Science.gov (United States)

    Storey, Bobby E; Williamson, Lisa H; Howell, Sue B; Terrill, Thomas H; Berghaus, Roy; Vidyashankar, Anand N; Kaplan, Ray M

    2017-08-30

    Haemonchus contortus resistant to multiple anthelmintics threaten the viability of the small ruminant industry in areas where this parasite is prevalent. In response to this situation, the FAMACHA© system was developed and validated for use with small ruminants as a way to detect clinical anemia associated with haemonchosis. Given that H. contortus and multiple anthelmintic resistance is a similar problem in camelids, the FAMACHA© system might also provide the same benefits. To address this need, a validation study of the FAMACHA© system was conducted on 21 alpaca and llama farms over a 2-year period. H. contortus was the predominant nematode parasite on 17 of the 21 farms (10 alpaca and 7 llama farms) enrolled in the study, based on fecal culture results. The FAMACHA© card was used to score the color of the lower palpebral (lower eye lid) conjunctiva on a 1-5 scale. Packed cell volume (PCV) values were measured and compared to FAMACHA© scores using FAMACHA© score cutoffs of ≥3 or ≥4 and with anemia defined as a PCV ≤15%, ≤17%, or≤20%. PCV was significantly associated with FAMACHA© score, fecal egg count (FEC), and body condition score (BCS), regardless of the FAMACHA© cutoff score or the PCV% chosen to define clinical anemia (p<0.01 in all cases). The use of FAMACHA© scores ≥3 and PCV ≥ 15% indicating anemia provided the best sensitivity (96.4% vs 92.9% for FAMACHA© ≥4), whereas FAMACHA scores ≥ 4 and PCV ≤20% provided the best specificity (94.2% vs 69.1% for FAMACHA© ≥3). The data from this study support the FAMACHA© system as a useful tool for detecting clinical anemia in camelids suffering from haemonchosis. Parameters for making treatment decisions based on FAMACHA© score in camelids should mirror those established for small ruminants. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Validation Of Intermediate Large Sample Analysis (With Sizes Up to 100 G) and Associated Facility Improvement

    International Nuclear Information System (INIS)

    Bode, P.; Koster-Ammerlaan, M.J.J.

    2018-01-01

    Pragmatic rather than physical correction factors for neutron and gamma-ray shielding were studied for samples of intermediate size, i.e. up to the 10-100 gram range. It was found that for most biological and geological materials, the neutron self-shielding is less than 5 % and the gamma-ray self-attenuation can easily be estimated. A trueness control material of 1 kg size was made based on use of left-overs of materials, used in laboratory intercomparisons. A design study for a large sample pool-side facility, handling plate-type volumes, had to be stopped because of a reduction in human resources, available for this CRP. The large sample NAA facilities were made available to guest scientists from Greece and Brazil. The laboratory for neutron activation analysis participated in the world’s first laboratory intercomparison utilizing large samples. (author)

  13. Data Validation Package May 2015, Groundwater Sampling at the Shoal, Nevada, Site

    International Nuclear Information System (INIS)

    Findlay, Rick; Kautsky, Mark

    2016-01-01

    The U.S. Department of Energy Office of Legacy Management conducted annual sampling at the Shoal, Nevada, Site (Shoal) in May 2015. Groundwater samples were collected from wells MV-1, MV-2, MV-3, MV-4, MV-5, H-3, HC-1, HC-2d, HC-3, HC-4, HC-5, HC-6, HC-7, HC-8, and HS-1. Sampling was conducted as specified in the Sampling and Analysis Plan for US. Department of Energy Office of Legacy Management Sites: LMS/PRO/S04351, continually updated, http://energy.gov/lm/downloads/sampling-and-analysis-plan-us-department- energy-office-legacy-management-sites. Monitoring wells MV-1, MV-2, MV-3, MV-4, MV-5, HC-2d, HC-4, HC-5, HC-7, HC-8, and HS-1 were purged prior to sampling using dedicated submersible pumps. At least one well casing volume was removed, and field parameters (temperature, pH, and specific conductance) were allowed to stabilize before samples were collected. Samples were collected from wells H-3, HC-1, HC-3, and HC-6 using a depth-specific bailer because these wells are not completed with dedicated submersible pumps. Samples were submitted under Requisition Index Number (RIN) 15057042 to ALS Laboratory Group in Fort Collins, Colorado, for the determination of bromide, gross alpha, gross beta, tritium, uranium isotopes, and total uranium (by mass); and under RIN 15057043 to the University of Arizona for the determination of carbon-14 and iodine-129. A duplicate sample from location MV-2 was included with RIN 15057042. The laboratory results from the 2015 sampling event are consistent with those of previous years with the exception of sample results from well HC-4. This well continues to be the only well with tritium concentrations above the laboratory's minimum detectable concentration which is attributed to the wells proximity to the nuclear detonation. The tritium concentration (731 picocuries per liter [pCi/L]) is consistent with past results and is below the U.S. Environmental Protection Agency's (EPA) maximum contaminant level (MCL) of 20,000 p

  14. Data Validation Package May 2015, Groundwater Sampling at the Shoal, Nevada, Site

    Energy Technology Data Exchange (ETDEWEB)

    Findlay, Rick [Navarro Research and Engineering, Oak Ridge, TN (United States); Kautsky, Mark [US Department of Energy, Washington, DC (United States). Office of Legacy Management

    2016-03-01

    The U.S. Department of Energy Office of Legacy Management conducted annual sampling at the Shoal, Nevada, Site (Shoal) in May 2015. Groundwater samples were collected from wells MV-1, MV-2, MV-3, MV-4, MV-5, H-3, HC-1, HC-2d, HC-3, HC-4, HC-5, HC-6, HC-7, HC-8, and HS-1. Sampling was conducted as specified in the Sampling and Analysis Plan for US. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated, http://energy.gov/lm/downloads/sampling-and-analysis-plan-us-department-energy­ office-legacy-management-sites). Monitoring wells MV-1, MV-2, MV-3, MV-4, MV-5, HC-2d, HC-4, HC-5, HC-7, HC-8, and HS-1 were purged prior to sampling using dedicated submersible pumps. At least one well casing volume was removed, and field parameters (temperature, pH, and specific conductance) were allowed to stabilize before samples were collected. Samples were collected from wells H-3, HC-1, HC-3, and HC-6 using a depth-specific bailer because these wells are not completed with dedicated submersible pumps. Samples were submitted under Requisition Index Number (RIN) 15057042 to ALS Laboratory Group in Fort Collins, Colorado, for the determination of bromide, gross alpha, gross beta, tritium, uranium isotopes, and total uranium (by mass); and under RIN 15057043 to the University of Arizona for the determination of carbon-14 and iodine-129. A duplicate sample from location MV-2 was included with RIN 15057042. The laboratory results from the 2015 sampling event are consistent with those of previous years with the exception of sample results from well HC-4. This well continues to be the only well with tritium concentrations above the laboratory’s minimum detectable concentration which is attributed to the wells proximity to the nuclear detonation. The tritium concentration (731 picocuries per liter [pCi/L]) is consistent with past results and is below the U.S. Environmental Protection Agency's (EPA) maximum contaminant level (MCL) of 20,000 p

  15. Validation of the Cristallini Sampling Method for UF6 by High Precision Double-Spike Measurements

    OpenAIRE

    RICHTER STEPHAN; JAKOBSSON ULF; HIESS JOE; AMARAGGI D.

    2017-01-01

    The so-called "Cristallini Method" for sampling of UF6 by adsorption and hydrolysis in alumina pellets inside a fluorothene P-10 tube was developed by the Brazilian-Argentine Agency for Accounting and Control of Nuclear Materials (ABACC) several years ago. This method has several advantages compared to the currently used sampling method, for which UF6 is distilled into a stainless steel tube for transportation, with hydrolysis and isotopic analysis being performed after shipping to the analyt...

  16. Demonstration/Validation of the Snap Sampler Passive Ground Water Sampling Device

    Science.gov (United States)

    2011-06-01

    purging and sampling protocol. Analytes that were measured at the Pease site included total and dissolved concentrations of arsenic (As), calcium ...samples remain in the original bottle in which they were collected, presumably losses of volatiles and changes in concentrations of dissolved gases or...because of excavation and removal. This has resulted in hydraulically interconnected bedrock and overburden water- bearing zones in much of this area

  17. Data Validation Package, December 2015, Groundwater Sampling at the Bluewater, New Mexico, Disposal Site, September 2016

    Energy Technology Data Exchange (ETDEWEB)

    Tsosie, Bernadette [U. S. Department of Energy, Washington, DC (United States). Office of Legacy Management; Johnson, Richard [Navarro Research and Engineering, Oak Ridge, TN (United States)

    2016-09-01

    Groundwater samples were collected from monitoring wells at the Bluewater, New Mexico, Disposal Site to monitor groundwater contaminants as specified in the 1997 Long-Term Surveillance Plan for the DOE Bluewater (UMTRCA Title II) Disposal Site Near Grants, New Mexico (LTSP). Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for U.S. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). A duplicate sample was collected from location HMC-951. Alluvium wells are completed in the alluvial sediments in the former channel of the Rio San Jose, which was covered by basalt lava flows known as the El Malpais, and are identified by the suffix (M). Bedrock wells are completed in the San Andres Limestone/Glorieta Sandstone hydrologic unit (San Andres aquifer) and are identified by the suffix (SG). Wells HMC-951 and OBS-3 are also completed in the San Andres aquifer. The LTSP requires monitoring for molybdenum, selenium, uranium, and polychlorinated biphenyls (PCBs); PCB monitoring occurs only during November sampling events. This event included sampling for an expanded list of analytes to characterize the site aquifers and to support a regional groundwater investigation being conducted by the New Mexico Environment Department.

  18. Cryogenic Liquid Sample Acquisition System for Remote Space Applications

    Science.gov (United States)

    Mahaffy, Paul; Trainer, Melissa; Wegel, Don; Hawk, Douglas; Melek, Tony; Johnson, Christopher; Amato, Michael; Galloway, John

    2013-01-01

    There is a need to acquire autonomously cryogenic hydrocarbon liquid sample from remote planetary locations such as the lakes of Titan for instruments such as mass spectrometers. There are several problems that had to be solved relative to collecting the right amount of cryogenic liquid sample into a warmer spacecraft, such as not allowing the sample to boil off or fractionate too early; controlling the intermediate and final pressures within carefully designed volumes; designing for various particulates and viscosities; designing to thermal, mass, and power-limited spacecraft interfaces; and reducing risk. Prior art inlets for similar instruments in spaceflight were designed primarily for atmospheric gas sampling and are not useful for this front-end application. These cryogenic liquid sample acquisition system designs for remote space applications allow for remote, autonomous, controlled sample collections of a range of challenging cryogenic sample types. The design can control the size of the sample, prevent fractionation, control pressures at various stages, and allow for various liquid sample levels. It is capable of collecting repeated samples autonomously in difficult lowtemperature conditions often found in planetary missions. It is capable of collecting samples for use by instruments from difficult sample types such as cryogenic hydrocarbon (methane, ethane, and propane) mixtures with solid particulates such as found on Titan. The design with a warm actuated valve is compatible with various spacecraft thermal and structural interfaces. The design uses controlled volumes, heaters, inlet and vent tubes, a cryogenic valve seat, inlet screens, temperature and cryogenic liquid sensors, seals, and vents to accomplish its task.

  19. Validation of the VERITAS-Pro treatment adherence scale in a Spanish sample population with hemophilia

    Directory of Open Access Journals (Sweden)

    Cuesta-Barriuso R

    2017-03-01

    Full Text Available Rubén Cuesta-Barriuso,1–3 Ana Torres-Ortuño,4 Pilar Galindo-Piñana,4 Joaquín Nieto-Munuera,4 Natalie Duncan,5 José Antonio López-Pina6 1Department of Physiotherapy, School of Biomedical and Health Sciences, European University of Madrid, 2Fishemo, Centro Especial de Empleo, Spanish Federation of Hemophilia, 3Royal Foundation Victoria Eugenia, Madrid, 4Department of Psychiatry and Social Psychology, Faculty of Medicine, University of Murcia, Murcia, Spain; 5Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, USA; 6Department of Basic Psychology and Methodology, Faculty of Psychology, University of Murcia, Murcia, Spain Purpose: We aimed to conduct a validation in Spanish of the Validated Hemophilia Regimen Treatment Adherence Scale – Prophylaxis (VERITAS-Pro questionnaire for use in patients with hemophilia under prophylactic treatment.Patients and methods: The VERITAS-Pro scale was adapted through a process of back translation from English to Spanish. A bilingual native Spanish translator translated the scale from English to Spanish. Subsequently, a bilingual native English translator translated the scale from Spanish to English. The disagreements were resolved by agreement between the research team and translators. Seventy-three patients with hemophilia, aged 13–62 years, were enrolled in the study. The scale was applied twice (2 months apart to evaluate the test–retest reliability.Results: Internal consistency reliability was lower on the Spanish VERITAS-Pro than on the English version. Test–retest reliability was high, ranging from 0.83 to 0.92. No significant differences (P>0.05 were found between test and retest scores in subscales of VERITAS-Pro. In general, Spanish patients showed higher rates of nonadherence than American patients in all subscales.Conclusion: The Spanish version of the VERITAS-Pro has high levels of consistency and empirical validity. This scale can be administered to assess the degree of

  20. Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample

    Directory of Open Access Journals (Sweden)

    Andrea Burri, DrSc

    2018-06-01

    Full Text Available Background: To date, neither the original English nor any of the translated versions of the Sexual Complaints Screener for Women (SCS-W have been tested for their psychometric properties. Aim: To evaluate the validity and utility of the German version of the SCS-W by assessing content, convergent, and discriminant validity. Methods: A population sample of 309 women (mean age = 26.9 years completed the online survey and had matching data available on the SCS-W and the Female Sexual Function Index (FSFI. Spearman bivariate correlations between the SCS-W and FSFI domain scores and exploratory factor analysis with principal component analysis were conducted. Outcomes: Convergent validity was excellent for the domain of orgasm, good for satisfaction, dyspareunia, and the total questionnaire score, and acceptable for desire, lubrication, arousal, and vaginismus. Discriminant validity was present for all domains apart from arousal, lubrication, and vaginismus. Varimax rotation suggested an 8-factor model was the most robust. Clinical Implications: This brief screener seems suitable to provide a brief overview of female patients' sexual problems in a clinical setting. Strengths and Limitations: This is the 1st study to assess the psychometric properties of the German version of the SCS-W. However, available information on the psychometric properties of the German SCS-W was limited because the validity of the screener could not be counterchecked against a clinical diagnosis of female sexual dysfunction. Conclusion: Our results provide preliminary evidence of good validity of the German version of the SCS-W. Overall, the SCS-W can offer support for clinicians who are less familiar with sexual medicine and who might not routinely discuss sexual issues with their patients.Burri A, Porst H. Preliminary Validation of a German Version of the Sexual Complaints Screener for Women in a Female Population Sample. Sex Med 2018;6:123–130. Key Words: Female Sexual

  1. Reachable Distance Space: Efficient Sampling-Based Planning for Spatially Constrained Systems

    KAUST Repository

    Xinyu Tang,

    2010-01-25

    Motion planning for spatially constrained robots is difficult due to additional constraints placed on the robot, such as closure constraints for closed chains or requirements on end-effector placement for articulated linkages. It is usually computationally too expensive to apply sampling-based planners to these problems since it is difficult to generate valid configurations. We overcome this challenge by redefining the robot\\'s degrees of freedom and constraints into a new set of parameters, called reachable distance space (RD-space), in which all configurations lie in the set of constraint-satisfying subspaces. This enables us to directly sample the constrained subspaces with complexity linear in the number of the robot\\'s degrees of freedom. In addition to supporting efficient sampling of configurations, we show that the RD-space formulation naturally supports planning and, in particular, we design a local planner suitable for use by sampling-based planners. We demonstrate the effectiveness and efficiency of our approach for several systems including closed chain planning with multiple loops, restricted end-effector sampling, and on-line planning for drawing/sculpting. We can sample single-loop closed chain systems with 1,000 links in time comparable to open chain sampling, and we can generate samples for 1,000-link multi-loop systems of varying topologies in less than a second. © 2010 The Author(s).

  2. Comparison and Field Validation of Binomial Sampling Plans for Oligonychus perseae (Acari: Tetranychidae) on Hass Avocado in Southern California.

    Science.gov (United States)

    Lara, Jesus R; Hoddle, Mark S

    2015-08-01

    Oligonychus perseae Tuttle, Baker, & Abatiello is a foliar pest of 'Hass' avocados [Persea americana Miller (Lauraceae)]. The recommended action threshold is 50-100 motile mites per leaf, but this count range and other ecological factors associated with O. perseae infestations limit the application of enumerative sampling plans in the field. Consequently, a comprehensive modeling approach was implemented to compare the practical application of various binomial sampling models for decision-making of O. perseae in California. An initial set of sequential binomial sampling models were developed using three mean-proportion modeling techniques (i.e., Taylor's power law, maximum likelihood, and an empirical model) in combination with two-leaf infestation tally thresholds of either one or two mites. Model performance was evaluated using a robust mite count database consisting of >20,000 Hass avocado leaves infested with varying densities of O. perseae and collected from multiple locations. Operating characteristic and average sample number results for sequential binomial models were used as the basis to develop and validate a standardized fixed-size binomial sampling model with guidelines on sample tree and leaf selection within blocks of avocado trees. This final validated model requires a leaf sampling cost of 30 leaves and takes into account the spatial dynamics of O. perseae to make reliable mite density classifications for a 50-mite action threshold. Recommendations for implementing this fixed-size binomial sampling plan to assess densities of O. perseae in commercial California avocado orchards are discussed. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  3. Sampled-data models for linear and nonlinear systems

    CERN Document Server

    Yuz, Juan I

    2014-01-01

    Sampled-data Models for Linear and Nonlinear Systems provides a fresh new look at a subject with which many researchers may think themselves familiar. Rather than emphasising the differences between sampled-data and continuous-time systems, the authors proceed from the premise that, with modern sampling rates being as high as they are, it is becoming more appropriate to emphasise connections and similarities. The text is driven by three motives: ·      the ubiquity of computers in modern control and signal-processing equipment means that sampling of systems that really evolve continuously is unavoidable; ·      although superficially straightforward, sampling can easily produce erroneous results when not treated properly; and ·      the need for a thorough understanding of many aspects of sampling among researchers and engineers dealing with applications to which they are central. The authors tackle many misconceptions which, although appearing reasonable at first sight, are in fact either p...

  4. Rapid surface sampling and archival record system (RSSAR)

    International Nuclear Information System (INIS)

    Barren, E.; Bracco, A.; Dorn, S.B.

    1997-01-01

    Purpose is to develop a rapid surface (concrete, steel) contamination measurement system that will provide a ''quick-look'' indication of contamination areas, an archival record, and an automated analysis. A bulk sampling oven is also being developed. The sampling device consists of a sampling head, a quick look detector, and an archiving system (sorbent tube). The head thermally desorbs semi-volatiles, such as PCBs, oils, etc., from concrete and steel surfaces; the volatilized materials are passed through a quick-look detector. Sensitivity of the detector can be attenuated for various contaminant levels. Volatilized materials are trapped in a tube filled with adsorbent. The tubes are housed in a magazine which also archives information about sampling conditions. Analysis of the tubes can be done at a later date. The concrete sampling head is fitted with a tungsten-halogen lamp; in laboratory experiments it has extracted model contaminants by heating the top 4mm of the surface to 250 C within 100-200 s. The steel sampling head has been tested on different types of steels and has extracted model contaminants within 30 s. A mathematical model of heat and mass transport in concrete has been developed. Rate of contaminant removal is at maximum when the moisture content is about 100 kg/m 3 . The system will be useful during decontamination and decommissioning operations

  5. Research of pneumatic control transmission system for small irradiation samples

    International Nuclear Information System (INIS)

    Bai Zhongxiong; Zhang Haibing; Rong Ru; Zhang Tao

    2008-01-01

    In order to reduce the absorbed dose damage for the operator, pneumatic control has been adopted to realize the rapid transmission of small irradiation samples. On/off of pneumatic circuit and directions for the rapid transmission system are controlled by the electrical control part. The main program initializes the system and detects the location of the manual/automatic change-over switch, and call for the corresponding subprogram to achieve the automatic or manual operation. Automatic subprogram achieves the automatic sample transmission; Manual subprogram completes the deflation, and back and forth movement of the radiation samples. This paper introduces in detail the implementation of the system, in terms of both hardware and software design. (authors)

  6. System design description for sampling fuel in K basins

    International Nuclear Information System (INIS)

    Baker, R.B.

    1996-01-01

    This System Design Description provides: (1) statements of the Spent Nuclear Fuel Projects (SNFP) needs requiring sampling of fuel in the K East and K West Basins, (2) the sampling equipment functions and requirements, (3) a general work plan and the design logic being followed to develop the equipment, and (4) a summary description of the design for the sampling equipment. The report summarizes the integrated application of both the subject equipment and the canister sludge sampler in near-term characterization campaigns at K Basins

  7. Flight critical system design guidelines and validation methods

    Science.gov (United States)

    Holt, H. M.; Lupton, A. O.; Holden, D. G.

    1984-01-01

    Efforts being expended at NASA-Langley to define a validation methodology, techniques for comparing advanced systems concepts, and design guidelines for characterizing fault tolerant digital avionics are described with an emphasis on the capabilities of AIRLAB, an environmentally controlled laboratory. AIRLAB has VAX 11/750 and 11/780 computers with an aggregate of 22 Mb memory and over 650 Mb storage, interconnected at 256 kbaud. An additional computer is programmed to emulate digital devices. Ongoing work is easily accessed at user stations by either chronological or key word indexing. The CARE III program aids in analyzing the capabilities of test systems to recover from faults. An additional code, the semi-Markov unreliability program (SURE) generates upper and lower reliability bounds. The AIRLAB facility is mainly dedicated to research on designs of digital flight-critical systems which must have acceptable reliability before incorporation into aircraft control systems. The digital systems would be too costly to submit to a full battery of flight tests and must be initially examined with the AIRLAB simulation capabilities.

  8. A New Cryogenic Sample Manipulator For SRC's Scienta 2002 System

    International Nuclear Information System (INIS)

    Gundelach, Chad T.; Fisher, Mike V.; Hoechst, Hartmut

    2004-01-01

    We discuss the first bench tests of a sample manipulator which was recently designed at SRC for the Scienta 2002 User system. The manipulator concept utilizes the 10 deg. angular window of the Scienta in the horizontal plane (angle dispersion) by rotating the sample normal around the vertical axis while angular scans along the vertical axis (energy dispersion) are continuous within ±30 deg. relative to the electron lens by rotating the sample around the horizontal axis. With this concept it is possible to precisely map the entire two-dimensional k-space of a crystal by means of stitching together 10 deg. wide stripes centered +15 deg. to -50 deg. relative to the sample normal. Three degrees of translational freedom allow positioning the sample surface at the focal point of the analyzer. Two degrees of rotational freedom are available at this position for manipulating the sample. Samples are mounted to a standard holder and transferred to the manipulator via a load-lock system attached to a prep chamber. The manipulator is configured with a cryogenic cold head, an electrical heater, and a temperature sensor permitting continuous closed-loop operation for 20-380 K

  9. Provenance validation of polished rice samples using nuclear and isotopic analytical techniques

    International Nuclear Information System (INIS)

    Pabroa, P.C.B.; Sucgang, R.J.; Mendoza, N.D.S.; Ebihara, M.; Peña, M.

    2015-01-01

    Rice (Oryza sativa) has been considered the best staple food among all cereals and is the staple food for over 3 billion people, constituting over half of the world’s population. Elemental and isotopic analysis revealed variance between Philippine and Japanese rice. Rice samples collected in Japan and in the Philippines (market survey samples from Metro Manila, and farm harvests from Aklan province and Central Luzon) were washed, dried and ground to fine powder. Elemental analyses of the samples were carried out using instrumental neutron activation analysis (INAA) while isotopic signatures of the samples were determined using the isotope ratio mass spectrometry (IRMS). Results show that compared with the unpolished rice standard NIES CRM10b, the polished Japanese and Philippine rice sampled show reduced concentrations of elements by as much as 1/10. 1/4 , 1/5 and 1/3 for Mg, Mn, K and Na, respectively. Levels of Ca and Zn are not greatly affected. Arsenic, probably introduced from fertilizers used in rice fields is found in all the Japanese rice tested at an average concentration of 0.103 μg/g and three out of four of the Philippine rice at an average concentration of 0.70μg/g. Higher levels of Br seen in two of the Philippine rice at 14 and 34μg/g indicated probable contamination source from the pesticide methyl bromide during quarantine. Good correlation of isotopic signatures with geographical location of polished, but not for unpolished, rice samples from Central Luzon and Aklan indicated that provenance studies are best done on polished rice samples. Isotopic with of ω’”13C show signature that of a C3 plant with possible narrow distinguishable signature with Japanese rice falling within -27.5 to -28.5 while Philippine rice within -29 to -30. Rice provenance can be ascertained using elemental analysis and isotopic abundance determination as shown by the study.(author)

  10. Indigenous development of automated metallographic sample preparation system

    International Nuclear Information System (INIS)

    Kulkarni, A.P.; Pandit, K.M.; Deshmukh, A.G.; Sahoo, K.C.

    2005-01-01

    Surface preparation of specimens for Metallographic studies on irradiated material involves a lot of remote handling of radioactive material by skilled manpower. These are laborious and man-rem intensive activities and put limitations on number of samples that can be prepared for the metallographic studies. To overcome these limitations, automated systems have been developed for surface preparation of specimens in PIE division. The system includes (i) Grinding and polishing stations (ii) Water jet cleaning station (iii) Ultrasonic cleaning stations (iv) Drying station (v) Sample loading and unloading station (vi) Dispenser for slurries and diluents and (vii) Automated head for movement of the sample holder disc from one station to other. System facilities the operator for programming/changing sequence of the sample preparations including remote changing of grinding/polishing discs from the stations. Two such systems have been installed and commissioned in Hot Cell for PIE Division. These are being used for preparation of irradiated samples from nuclear fuels and structural components. This development has increased the throughput of metallography work and savings in terms of (man-severts) radiation exposure to operators. This presentation will provide details of the challenges in undertaking this developmental work. (author)

  11. The perceived personal control (PPC) questionnaire: reliability and validity in a sample from the United Kingdom.

    Science.gov (United States)

    McAllister, Marion; Wood, Alex M; Dunn, Graham; Shiloh, Shoshana; Todd, Chris

    2012-02-01

    Outcome measures are important assessment tools to evaluate clinical genetics services. Research suggests that perceived personal control (PPC) is an outcome valued by clinical genetics patients and clinicians. The PPC scale was developed in Hebrew to capture three dimensions of PPC: Cognitive, decisional, and behavioral control. This article reports on the first psychometric validation of the English translation of the PPC scale. Previous research has shown that the Hebrew and Dutch translations have good psychometric properties. However, the psychometric properties of the English translation have not been tested, and there is disagreement about the factor structure, with implications for how to score the measure. A total of 395 patients attending a clinical genetics appointment in the United Kingdom completed several measures at baseline, and a further 241 also completed measures at 2-4 weeks follow-up. The English language PPC has (a) a one-factor structure, (b) convergent validity with internal health locus of control (IHLC), satisfaction with life (SWL), depression, and authenticity, (c) high internal consistency (α = 0.83), and (d) sensitivity to change, being able to identify moderate changes in PPC following clinic attendance (Cohen's d = 0.40). These properties suggest the English language PPC measure is a useful tool for both clinical genetics research and for use as a Patient Reported Outcome Measure (PROM) in service evaluation. Copyright © 2011 Wiley Periodicals, Inc.

  12. A preliminary study to assess the construct validity of a cultural intelligence measure on a South African sample

    Directory of Open Access Journals (Sweden)

    Bright Mahembe

    2014-09-01

    Research purpose: The purpose of the current study was to assess the construct validity of the CQS on a South African sample. The results of the psychometric assessment offer some important insights into the factor structure of the cultural intelligence construct. Motivation for the study: The current study sought to provide some practical validity confirmation of the CQS for the effective management of cultural diversity in the South African context. Research approach, design and method: The CQS was administered on a non-probability sample of 229 young adults in South Africa. Item analysis was performed to ascertain reliability. Exploratory factor analysis was used to test the unidimensionality of CQS subscales. The first-order and second-order factor structures underlying contemporary models of cultural intelligence were tested using confirmatory factor analysis. Main findings: Results indicated that the CQS is a reliable and valid measure of cultural intelligence as evidenced by the high internal consistency coefficients in all the subscales. Good construct validity for both the first-order and second-order models was obtained via confirmatory factor analysis. Practical/managerial implications: The study finds good measurement properties of the CQS in a South African context. The CQS can be confidently used for applications such as selecting, training and developing a more culturally competent workforce. Contribution: The study extends the body of knowledge on the reliability and construct validity of the CQS in the South African milieu. It further indicates that cultural intelligence can be represented by a general cultural intelligence factor that drives more specific dimensions of cultural intelligence.

  13. Sampling

    CERN Document Server

    Thompson, Steven K

    2012-01-01

    Praise for the Second Edition "This book has never had a competitor. It is the only book that takes a broad approach to sampling . . . any good personal statistics library should include a copy of this book." —Technometrics "Well-written . . . an excellent book on an important subject. Highly recommended." —Choice "An ideal reference for scientific researchers and other professionals who use sampling." —Zentralblatt Math Features new developments in the field combined with all aspects of obtaining, interpreting, and using sample data Sampling provides an up-to-date treat

  14. Computer-controlled sampling system for airborne particulates

    International Nuclear Information System (INIS)

    Hall, C.F.; Anspaugh, L.R.; Koval, J.S.; Phelps, P.L.; Steinhaus, R.J.

    1975-01-01

    A self-contained, mobile, computer-controlled air-sampling system has been designed and fabricated that also collects and records the data from eight meteorological sensors. The air-samplers are activated automatically when the collected meteorological data meet the criteria specified at the beginning of the data-collection run. The filters from the samplers are intended to collect airborne 239 Pu for later radionuclide analysis and correlation with the meteorological data for the study of resuspended airborne radioactivity and for the development of a predictive model. This paper describes the system hardware, discusses the system and software concepts, and outlines the operational procedures for the system

  15. A validation system for data preservation in HEP

    International Nuclear Information System (INIS)

    Kemp, Yves; Strutz, Marco; Hessling, Hermann

    2012-01-01

    Preserving data from past experiments and preserving the ability to perform analysis with old data is of growing importance in many domains of science, including High Energy Physics (HEP). A study group on this issue, DPHEP, has been established in this field to provide guidelines and a structure for international collaboration on data preservation projects in HEP. This contribution presents a framework that allows experimentalists to validate their software against a previously defined set of tests in an automated way. The framework has been designed with a special focus for longevity, as it makes use of open protocols, has a modular design and is based on simple communication mechanisms. On the fabrics side, tests are carried out in a virtual environment using a cloud infrastructure. Within the framework, it is easy to run validation tests on different hardware platforms, or different major or minor versions of operating systems. Experts from IT or the experiments can automatically detect failures in the test procedure by the help of reporting tools. Hence, appropriate actions can be taken in a timely manner. The design and important implementation aspects of the framework are shown and first experiences from early-bird users will be presented.

  16. Construct Validity of the Nutrition and Activity Knowledge Scale in a French Sample of Adolescents with Mild to Moderate Intellectual Disability

    Science.gov (United States)

    Maiano, Christophe; Begarie, Jerome; Morin, Alexandre J. S.; Garbarino, Jean-Marie; Ninot, Gregory

    2010-01-01

    The purpose of this study was to test the reliability (i.e. internal consistency and test-retest reliability) and construct validity (i.e. content validity, factor validity, measurement invariance, and latent mean invariance) of the Nutrition and Activity Knowledge Scale (NAKS) in a sample of French adolescents with mild to moderate Intellectual…

  17. Multi-actuators vehicle collision avoidance system - Experimental validation

    Science.gov (United States)

    Hamid, Umar Zakir Abdul; Zakuan, Fakhrul Razi Ahmad; Akmal Zulkepli, Khairul; Zulfaqar Azmi, Muhammad; Zamzuri, Hairi; Rahman, Mohd Azizi Abdul; Aizzat Zakaria, Muhammad

    2018-04-01

    The Insurance Institute for Highway Safety (IIHS) of the United States of America in their reports has mentioned that a significant amount of the road mishaps would be preventable if more automated active safety applications are adopted into the vehicle. This includes the incorporation of collision avoidance system. The autonomous intervention by the active steering and braking systems in the hazardous scenario can aid the driver in mitigating the collisions. In this work, a real-time platform of a multi-actuators vehicle collision avoidance system is developed. It is a continuous research scheme to develop a fully autonomous vehicle in Malaysia. The vehicle is a modular platform which can be utilized for different research purposes and is denominated as Intelligent Drive Project (iDrive). The vehicle collision avoidance proposed design is validated in a controlled environment, where the coupled longitudinal and lateral motion control system is expected to provide desired braking and steering actuation in the occurrence of a frontal static obstacle. Results indicate the ability of the platform to yield multi-actuators collision avoidance navigation in the hazardous scenario, thus avoiding the obstacle. The findings of this work are beneficial for the development of a more complex and nonlinear real-time collision avoidance work in the future.

  18. Verification and Validation of Flight-Critical Systems

    Science.gov (United States)

    Brat, Guillaume

    2010-01-01

    For the first time in many years, the NASA budget presented to congress calls for a focused effort on the verification and validation (V&V) of complex systems. This is mostly motivated by the results of the VVFCS (V&V of Flight-Critical Systems) study, which should materialize as a a concrete effort under the Aviation Safety program. This talk will present the results of the study, from requirements coming out of discussions with the FAA and the Joint Planning and Development Office (JPDO) to technical plan addressing the issue, and its proposed current and future V&V research agenda, which will be addressed by NASA Ames, Langley, and Dryden as well as external partners through NASA Research Announcements (NRA) calls. This agenda calls for pushing V&V earlier in the life cycle and take advantage of formal methods to increase safety and reduce cost of V&V. I will present the on-going research work (especially the four main technical areas: Safety Assurance, Distributed Systems, Authority and Autonomy, and Software-Intensive Systems), possible extensions, and how VVFCS plans on grounding the research in realistic examples, including an intended V&V test-bench based on an Integrated Modular Avionics (IMA) architecture and hosted by Dryden.

  19. Expert systems application to plant diagnosis and sensor data validation

    International Nuclear Information System (INIS)

    Hashemi, S.; Hajek, B.K.; Miller, D.W.; Chandrasekaran, B.; Josephson, J.R.

    1986-01-01

    In a nuclear power plant, over 2000 alarms and displays are available to the operator. For any given set of alarms and displays, the operator must be able to diagnose and correct the problem (s) quickly and accurately. At the same time, the operator is expected to distinguish the plant system faults from instrumentation channel failures and drifts. Needs for plant operator aids have been considered since the accident at TMI. Many of these aids are of the form of the Safety Parameter Display Systems and offer improved methods of displaying otherwise available data to the operator in a more concise and summarized format. diagnosis, however, remains a desirable objective of an operator aid. At The Ohio State University, faculty and students in nuclear engineering and computer science have evaluated this problem. The results of these studies have shown that plant diagnosis and sensor data validation must be considered as one integral problem and cannot be isolated from one another. Otherwise, an incorrect diagnosis based on faulty instrument information might be provided to the operator. In this study, the Knowlege Based System (KBS) technology is being incorporated to accomplish a final goal of an intelligent operator aid system

  20. Design validation and performance of closed loop gas recirculation system

    International Nuclear Information System (INIS)

    Kalmani, S.D.; Majumder, G.; Mondal, N.K.; Shinde, R.R.; Joshi, A.V.

    2016-01-01

    A pilot experimental set up of the India Based Neutrino Observatory's ICAL detector has been operational for the last 4 years at TIFR, Mumbai. Twelve glass RPC detectors of size 2 × 2 m 2 , with a gas gap of 2 mm are under test in a closed loop gas recirculation system. These RPCs are continuously purged individually, with a gas mixture of R134a (C 2 H 2 F 4 ), isobutane (iC 4 H 10 ) and sulphur hexafluoride (SF 6 ) at a steady rate of 360 ml/h to maintain about one volume change a day. To economize gas mixture consumption and to reduce the effluents from being released into the atmosphere, a closed loop system has been designed, fabricated and installed at TIFR. The pressure and flow rate in the loop is controlled by mass flow controllers and pressure transmitters. The performance and integrity of RPCs in the pilot experimental set up is being monitored to assess the effect of periodic fluctuation and transients in atmospheric pressure and temperature, room pressure variation, flow pulsations, uniformity of gas distribution and power failures. The capability of closed loop gas recirculation system to respond to these changes is also studied. The conclusions from the above experiment are presented. The validations of the first design considerations and subsequent modifications have provided improved guidelines for the future design of the engineering module gas system.

  1. Sampling and analysis validates acceptable knowledge on LANL transuranic, heterogeneous, debris waste, or ''Cutting the Gordian knot that binds WIPP''

    International Nuclear Information System (INIS)

    Kosiewicz, S.T.; Triay, I.R.; Souza, L.A.

    1999-01-01

    Through sampling and toxicity characteristic leaching procedure (TCLP) analyses, LANL and the DOE validated that a LANL transuranic (TRU) waste (TA-55-43, Lot No. 01) was not a Resource Recovery and Conservation Act (RCRA) hazardous waste. This paper describes the sampling and analysis project as well as the statistical assessment of the analytical results. The analyses were conducted according to the requirements and procedures in the sampling and analysis plan approved by the New Mexico Environmental Department. The plan used a statistical approach that was consistent with the stratified, random sampling requirements of SW-846. LANL adhered to the plan during sampling and chemical analysis of randomly selected items of the five major types of materials in this heterogeneous, radioactive, debris waste. To generate portions of the plan, LANL analyzed a number of non-radioactive items that were representative of the mix of items present in the waste stream. Data from these cold surrogates were used to generate means and variances needed to optimize the design. Based on statistical arguments alone, only two samples from the entire waste stream were deemed necessary, however a decision was made to analyze at least two samples of each of the five major waste types. To obtain these samples, nine TRU waste drums were opened. Sixty-six radioactively contaminated and four non-radioactive grab samples were collected. Portions of the samples were composited for chemical analyses. In addition, a radioactively contaminated sample of rust-colored powder of interest to the New Mexico Environment Department (NMED) was collected and qualitatively identified as rust

  2. The Validation of AAN Method Used by Rock Sample SRM 2780

    International Nuclear Information System (INIS)

    Rina Mulyaningsih, Th.

    2004-01-01

    AAN methods is a non standard testing method. The testing laboratory must be validate its using method to ensure and confirm that it is suitable with application. The analysis of SRM 2780 Hard rock mine waste with 9 replicates has been done to test the accuracy of AAN methods. The result showed that the elements As, Ba, Mn, V, Zn and Na have good accuration were evaluated against the acceptance criteria for accuracy with confidence level 95 %. The elements As, Co, Sc, Cr, Ba, Sb, Cs, Mn, V, Au, Zn and Na have low relative bias between the analyst's value and the target value. The continued testing must be done to test the accuracy of another certificated elements. (author)

  3. Cross-Cultural Validation of the Basic Psychological Needs in Physical Education Scale between Portugal and Brazil Samples.

    Science.gov (United States)

    Cid, Luis; Lettnin, Carla; Stobäus, Claus; Monteiro, Diogo; Davoglio, Tárcia; Moutão, João

    2016-02-19

    The main propose of this study is the cross-cultural validation of the Basic Psychological Needs in Physical Education Scale among Portugal and Brazil samples, through the study of measurement model invariance. Participated in this study, two independent samples, one with 616 Portuguese students, of the 2nd and 3rd basic grade of public school, aged between 9 and 18 years old and another with 450 Brazilian students, from 1st, 2nd and 3rd middle grade of public and private school, aged between 14 and 18 years old. The results support the suitability of the model (three factors, each one with four items), showing an adequate fit to the data in each sample (Portugal: χ2 = 203.8, p = .001, df = 51, SRMR = .062, NNFI = .926, CFI = .943, RMSEA = .070, RMSEA 90% IC = .060-.080; Brazil: χ2 = 173.7, p = .001, df = 51, SRMR = .052, NNFI = .940, CFI = .954, RMSEA = .073, RMSEA 90% IC = .061-.085), as well valid cross-cultural invariance among Portuguese e Brazilian samples (∆CFI ≤ .01). Those findings allow us to conclude that scale can be used to measure the basic psychological needs in physical education in Portugal and in Brazil.

  4. Validation of networks derived from snowball sampling of municipal science education actors

    DEFF Research Database (Denmark)

    von der Fehr, Ane; Sølberg, Jan; Bruun, Jesper

    2016-01-01

    predictions based on existing knowledge of the municipalities aligned with SNA data. However, these discrepancies could be explained by development in the municipalities in the time following previous investigations. This study shows that snowball sampling is an applicable method to use for mapping hidden...

  5. Support vector machine classification and validation of cancer tissue samples using microarray expression data.

    Science.gov (United States)

    Furey, T S; Cristianini, N; Duffy, N; Bednarski, D W; Schummer, M; Haussler, D

    2000-10-01

    DNA microarray experiments generating thousands of gene expression measurements, are being used to gather information from tissue and cell samples regarding gene expression differences that will be useful in diagnosing disease. We have developed a new method to analyse this kind of data using support vector machines (SVMs). This analysis consists of both classification of the tissue samples, and an exploration of the data for mis-labeled or questionable tissue results. We demonstrate the method in detail on samples consisting of ovarian cancer tissues, normal ovarian tissues, and other normal tissues. The dataset consists of expression experiment results for 97,802 cDNAs for each tissue. As a result of computational analysis, a tissue sample is discovered and confirmed to be wrongly labeled. Upon correction of this mistake and the removal of an outlier, perfect classification of tissues is achieved, but not with high confidence. We identify and analyse a subset of genes from the ovarian dataset whose expression is highly differentiated between the types of tissues. To show robustness of the SVM method, two previously published datasets from other types of tissues or cells are analysed. The results are comparable to those previously obtained. We show that other machine learning methods also perform comparably to the SVM on many of those datasets. The SVM software is available at http://www.cs. columbia.edu/ approximately bgrundy/svm.

  6. Individualized Sampling Parameters for Behavioral Observations: Enhancing the Predictive Validity of Competing Stimulus Assessments

    Science.gov (United States)

    DeLeon, Iser G.; Toole, Lisa M.; Gutshall, Katharine A.; Bowman, Lynn G.

    2005-01-01

    Recent studies have used pretreatment analyses, termed competing stimulus assessments, to identify items that most effectively displace the aberrant behavior of individuals with developmental disabilities. In most studies, there appeared to have been no systematic basis for selecting the sampling period (ranging from 30 s to 10 min) in which items…

  7. Validation of dipslides as a tool for environmental sampling in a real-life hospital setting

    DEFF Research Database (Denmark)

    Ibfelt, T; Foged, Charlotte Bernhardt Laiho; Andersen, L P

    2014-01-01

    Environmental sampling in hospitals is becoming increasingly important because of the rise in nosocomial infections. In order to monitor and track these infections and optimize cleaning and disinfection, we need to be able to locate the fomites with the highest amount of microorganisms, but the o...

  8. Validation of Networks Derived from Snowball Sampling of Municipal Science Education Actors

    Science.gov (United States)

    von der Fehr, Ane; Sølberg, Jan; Bruun, Jesper

    2018-01-01

    Social network analysis (SNA) has been used in many educational studies in the past decade, but what these studies have in common is that the populations in question in most cases are defined and known to the researchers studying the networks. Snowball sampling is an SNA methodology most often used to study hidden populations, for example, groups…

  9. Data Validation Package May 2016 Groundwater Sampling at the Sherwood, Washington, Disposal Site August 2016

    Energy Technology Data Exchange (ETDEWEB)

    Kreie, Ken [USDOE Office of Legacy Management, Washington, DC (United States); Traub, David [Navarro Research and Engineering, Inc., Oak Ridge, TN (United States)

    2016-08-04

    The 2001 Long-Term Surveillance Plan (LTSP) for the US. Department of Energy Sherwood Project (UMI'RCA Title II) Reclamation Cell, Wellpinit, Washington, does not require groundwater compliance monitoring at the Sherwood site. However, the LTSP stipulates limited groundwater monitoring for chloride and sulfate (designated indicator parameters) and total dissolved solids (TDS) as a best management practice. Samples were collected from the background well, MW-2B, and the two downgradient wells, MW-4 and MW-10, in accordance with the LTSP. Sampling and analyses were conducted as specified in the Sampling and Analysis Plan for US. Department of Energy Office of Legacy Management Sites (LMS/PRO/S04351, continually updated). Water levels were measured in all wells prior to sampling and in four piezometers completed in the tailings dam. Time-concentration graphs included in this report indicate that the chloride, sulfate, and TDS concentrations are consistent with historical measurements. The concentrations of chloride and sulfate are well below the State of Washington water quality criteria value of 250 milligrams per liter (mg/L) for both parameters.

  10. Modelling of the activity system - development of an evaluation method for integrated system validation

    International Nuclear Information System (INIS)

    Norros, Leena; Savioja, Paula

    2004-01-01

    In this paper we present our recent research which focuses on creating an evaluation method for human-system interfaces of complex systems. The method is aimed for use in the validation of modernised nuclear power plant (NPP) control rooms, and other complex systems with high reliability requirements. The task in validation is to determine whether the human-system functions safely and effectively. This question can be operationalized to the selection of relevant operational features and their appropriate acceptance criteria. Thus, there is a need to ensure that the results of the evaluation can be generalized so that they serve the purpose of integrated system validation. The definition of the appropriate acceptance criteria provides basis for the judgement of the appropriateness of the performance of the system. We propose that the operational situations and the acceptance criteria should be defined based on modelling of the NPP operation that is comprehended as an activity system. We developed a new core-tasks modelling framework. It is a formative modelling approach that combines causal, functional and understanding explanations of system performance. In this paper we reason how modelling can be used as a medium to determine the validity of the emerging control room system. (Author)

  11. Monte Carlo importance sampling optimization for system reliability applications

    International Nuclear Information System (INIS)

    Campioni, Luca; Vestrucci, Paolo

    2004-01-01

    This paper focuses on the reliability analysis of multicomponent systems by the importance sampling technique, and, in particular, it tackles the optimization aspect. A methodology based on the minimization of the variance at the component level is proposed for the class of systems consisting of independent components. The claim is that, by means of such a methodology, the optimal biasing could be achieved without resorting to the typical approach by trials

  12. Multi-dimensional virtual system introduced to enhance canonical sampling

    Science.gov (United States)

    Higo, Junichi; Kasahara, Kota; Nakamura, Haruki

    2017-10-01

    When an important process of a molecular system occurs via a combination of two or more rare events, which occur almost independently to one another, computational sampling for the important process is difficult. Here, to sample such a process effectively, we developed a new method, named the "multi-dimensional Virtual-system coupled Monte Carlo (multi-dimensional-VcMC)" method, where the system interacts with a virtual system expressed by two or more virtual coordinates. Each virtual coordinate controls sampling along a reaction coordinate. By setting multiple reaction coordinates to be related to the corresponding rare events, sampling of the important process can be enhanced. An advantage of multi-dimensional-VcMC is its simplicity: Namely, the conformation moves widely in the multi-dimensional reaction coordinate space without knowledge of canonical distribution functions of the system. To examine the effectiveness of the algorithm, we introduced a toy model where two molecules (receptor and its ligand) bind and unbind to each other. The receptor has a deep binding pocket, to which the ligand enters for binding. Furthermore, a gate is set at the entrance of the pocket, and the gate is usually closed. Thus, the molecular binding takes place via the two events: ligand approach to the pocket and gate opening. In two-dimensional (2D)-VcMC, the two molecules exhibited repeated binding and unbinding, and an equilibrated distribution was obtained as expected. A conventional canonical simulation, which was 200 times longer than 2D-VcMC, failed in sampling the binding/unbinding effectively. The current method is applicable to various biological systems.

  13. The validation of forensic DNA extraction systems to utilize soil contaminated biological evidence.

    Science.gov (United States)

    Kasu, Mohaimin; Shires, Karen

    2015-07-01

    The production of full DNA profiles from biological evidence found in soil has a high failure rate due largely to the inhibitory substance humic acid (HA). Abundant in various natural soils, HA co-extracts with DNA during extraction and inhibits DNA profiling by binding to the molecular components of the genotyping assay. To successfully utilize traces of soil contaminated evidence, such as that found at many murder and rape crime scenes in South Africa, a reliable HA removal extraction system would often be selected based on previous validation studies. However, for many standard forensic DNA extraction systems, peer-reviewed publications detailing the efficacy on soil evidence is either lacking or is incomplete. Consequently, these sample types are often not collected or fail to yield suitable DNA material due to the use of unsuitable methodology. The aim of this study was to validate the common forensic DNA collection and extraction systems used in South Africa, namely DNA IQ, FTA elute and Nucleosave for processing blood and saliva contaminated with HA. A forensic appropriate volume of biological evidence was spiked with HA (0, 0.5, 1.5 and 2.5 mg/ml) and processed through each extraction protocol for the evaluation of HA removal using QPCR and STR-genotyping. The DNA IQ magnetic bead system effectively removed HA from highly contaminated blood and saliva, and generated consistently acceptable STR profiles from both artificially spiked samples and crude soil samples. This system is highly recommended for use on soil-contaminated evidence over the cellulose card-based systems currently being preferentially used for DNA sample collection. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  14. Psychosocial Adjustment to Illness Scale: Factor structure, reliability, and validity assessment in a sample of Greek breast cancer patients.

    Science.gov (United States)

    Kolokotroni, Philippa; Anagnostopoulos, Fotios; Missitzis, Ioannis

    2017-07-01

    The study and measurement of psychosocial adjustment is important for evaluating patients' well-being, and assessing the illness's course, treatment's success, and patients' recovery. In this study, internal consistency reliability and construct validity of the Greek version of the Psychosocial Adjustment to Illness Scale-Self-Report (PAIS-SR) were examined. Demographic and psychosocial data were collected from a sample of 243 women with breast cancer, recruited from September 2011 to December 2012. With some exceptions in specific items, the original conceptually-derived PAIS-SR subscales emerged in a seven-factor solution. Social Environment, Job and Household Duties, and Psychological Distress accounted for more of the total variance than other subscales. PAIS-SR showed good internal consistency reliability, with Cronbach's alpha coefficients >0.62. Correlations of PAIS-SR domains with measures of quality of life and posttraumatic stress symptoms supported the convergent validity of the PAIS-SR and its significance for cancer research. The Greek version of the PAIS-SR has acceptable internal consistency reliability and construct validity, as well as satisfactory convergent validity. Results provide some suggestions for the development of programs to evaluate adjustment status and implement psychosocial interventions among breast cancer survivors.

  15. The cognition battery of the NIH toolbox for assessment of neurological and behavioral function: validation in an adult sample.

    Science.gov (United States)

    Weintraub, Sandra; Dikmen, Sureyya S; Heaton, Robert K; Tulsky, David S; Zelazo, Philip David; Slotkin, Jerry; Carlozzi, Noelle E; Bauer, Patricia J; Wallner-Allen, Kathleen; Fox, Nathan; Havlik, Richard; Beaumont, Jennifer L; Mungas, Dan; Manly, Jennifer J; Moy, Claudia; Conway, Kevin; Edwards, Emmeline; Nowinski, Cindy J; Gershon, Richard

    2014-07-01

    This study introduces a special series on validity studies of the Cognition Battery (CB) from the U.S. National Institutes of Health Toolbox for the Assessment of Neurological and Behavioral Function (NIHTB) (Gershon, Wagster et al., 2013) in an adult sample. This first study in the series describes the sample, each of the seven instruments in the NIHTB-CB briefly, and the general approach to data analysis. Data are provided on test-retest reliability and practice effects, and raw scores (mean, standard deviation, range) are presented for each instrument and the gold standard instruments used to measure construct validity. Accompanying papers provide details on each instrument, including information about instrument development, psychometric properties, age and education effects on performance, and convergent and discriminant construct validity. One study in the series is devoted to a factor analysis of the NIHTB-CB in adults and another describes the psychometric properties of three composite scores derived from the individual measures representing fluid and crystallized abilities and their combination. The NIHTB-CB is designed to provide a brief, comprehensive, common set of measures to allow comparisons among disparate studies and to improve scientific communication.

  16. Validation of the Narcissistic Admiration and Rivalry Questionnaire Short Scale (NARQ-S) in convenience and representative samples.

    Science.gov (United States)

    Leckelt, Marius; Wetzel, Eunike; Gerlach, Tanja M; Ackerman, Robert A; Miller, Joshua D; Chopik, William J; Penke, Lars; Geukes, Katharina; Küfner, Albrecht C P; Hutteman, Roos; Richter, David; Renner, Karl-Heinz; Allroggen, Marc; Brecheen, Courtney; Campbell, W Keith; Grossmann, Igor; Back, Mitja D

    2018-01-01

    Due to increased empirical interest in narcissism across the social sciences, there is a need for inventories that can be administered quickly while also reliably measuring both the agentic and antagonistic aspects of grandiose narcissism. In this study, we sought to validate the factor structure, provide representative descriptive data and reliability estimates, assess the reliability across the trait spectrum, and examine the nomological network of the short version of the Narcissistic Admiration and Rivalry Questionnaire (NARQ-S; Back et al., 2013). We used data from a large convenience sample (total N = 11,937) as well as data from a large representative sample (total N = 4,433) that included responses to other narcissism measures as well as related constructs, including the other Dark Triad traits, Big Five personality traits, and self-esteem. Confirmatory factor analysis and item response theory were used to validate the factor structure and estimate the reliability across the latent trait spectrum, respectively. Results suggest that the NARQ-S shows a robust factor structure and is a reliable and valid short measure of the agentic and antagonistic aspects of grandiose narcissism. We also discuss future directions and applications of the NARQ-S as a short and comprehensive measure of grandiose narcissism. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  17. A novel PMT test system based on waveform sampling

    Science.gov (United States)

    Yin, S.; Ma, L.; Ning, Z.; Qian, S.; Wang, Y.; Jiang, X.; Wang, Z.; Yu, B.; Gao, F.; Zhu, Y.; Wang, Z.

    2018-01-01

    Comparing with the traditional test system based on a QDC and TDC and scaler, a test system based on waveform sampling is constructed for signal sampling of the 8"R5912 and the 20"R12860 Hamamatsu PMT in different energy states from single to multiple photoelectrons. In order to achieve high throughput and to reduce the dead time in data processing, the data acquisition software based on LabVIEW is developed and runs with a parallel mechanism. The analysis algorithm is realized in LabVIEW and the spectra of charge, amplitude, signal width and rising time are analyzed offline. The results from Charge-to-Digital Converter, Time-to-Digital Converter and waveform sampling are discussed in detailed comparison.

  18. Control System Radioactive Contamination in Food Samples in Poland

    International Nuclear Information System (INIS)

    Grabowski, D.; Kurowski, W.; Muszynski, W.; Rubel, B.; Smagala, G.; Swietochowska, J.

    2001-01-01

    Full text: The analyses of the level of radioactive contamination in food samples are carried out by the Service for Measurements of Radioactive Contamination (SMRC) in Poland. The Service was brought into existence in 1961. The Service comprises of a network of measurement stations and the Centre of Radioactive Contamination Measurements (CRCM). The duty of the Centre is being executed by the Central Laboratory for Radiological Protection (CLRP). The uniform methods of sampling are used in measurement stations. All important foodstuff: milk, meat, vegetables, fruit, cereals are controlled in the Service stations. The radiochemical and spectrometric methods are used to determine the activity of radioactive isotopes. The standard equipment of the measurement station is the measurement system type SAPOS-90 and multichannel analyser with scintillation or germanium detector. The structure of the Service, kinds of samples tested by each station, program of sampling in normal and during accident situation are presented in this paper. (author)

  19. Authentication Assurance Level Application to the Inventory Sampling Measurement System

    International Nuclear Information System (INIS)

    Devaney, Mike M.; Kouzes, Richard T.; Hansen, Randy R.; Geelhood, Bruce D.

    2001-01-01

    This document concentrates on the identification of a standardized assessment approach for the verification of security functionality in specific equipment, the Inspection Sampling Measurement System (ISMS) being developed for MAYAK. Specifically, an Authentication Assurance Level 3 is proposed to be reached in authenticating the ISMS

  20. Optimal relaxed causal sampler using sampled-date system theory

    NARCIS (Netherlands)

    Shekhawat, Hanumant; Meinsma, Gjerrit

    This paper studies the design of an optimal relaxed causal sampler using sampled data system theory. A lifted frequency domain approach is used to obtain the existence conditions and the optimal sampler. A state space formulation of the results is also provided. The resulting optimal relaxed causal

  1. Laboratory diagnostic methods, system of quality and validation

    Directory of Open Access Journals (Sweden)

    Ašanin Ružica

    2005-01-01

    Full Text Available It is known that laboratory investigations secure safe and reliable results that provide a final confirmation of the quality of work. Ideas, planning, knowledge, skills, experience, and environment, along with good laboratory practice, quality control and reliability of quality, make the area of biological investigations very complex. In recent years, quality control, including the control of work in the laboratory, is based on international standards and is used at that level. The implementation of widely recognized international standards, such as the International Standard ISO/IEC 17025 (1 and the implementing of the quality system series ISO/IEC 9000 (2 have become the imperative on the grounds of which laboratories have a formal, visible and corresponding system of quality. The diagnostic methods that are used must constantly yield results which identify the animal as positive or negative, and the precise status of the animal is determined with a predefined degree of statistical significance. Methods applied on a selected population reduce the risk of obtaining falsely positive or falsely negative results. A condition for this are well conceived and documented methods, with the application of the corresponding reagents, and work with professional and skilled staff. This process requires also a consistent implementation of the most rigorous experimental plans, epidemiological and statistical data and estimations, with constant monitoring of the validity of the applied methods. Such an approach is necessary in order to cut down the number of misconceptions and accidental mistakes, for a referent population of animals on which the validity of a method is tested. Once a valid method is included in daily routine investigations, it is necessary to apply constant monitoring for the purpose of internal quality control, in order adequately to evaluate its reproducibility and reliability. Consequently, it is necessary at least twice yearly to conduct

  2. Validation of the DNATyper™15 PCR Genotyping System for Forensic Application

    Directory of Open Access Journals (Sweden)

    Jian Ye

    2015-01-01

    Full Text Available We describe the optimization and validation of the DNATyper™15 multiplex polymerase chain reaction (PCR genotyping system for autosomal short tandem repeat (STR amplification at 14 autosomal loci (D6S1043, D21S11, D7S820, CSF1PO, D2S1338, D3S1358, D13S317, D8S1179, D16S539, Penta E, D5S818, vWA, D18S51, and FGA and  amelogenin, a sex-determining locus. Several DNATyper™15 assay variables were optimized, including hot start Taq polymerase concentration, Taq polymerase activation time, magnesium concentration, primer concentration, annealing temperature, reaction volume, and cycle number. The performance of the assay was validated with respect to species specificity, sensitivity to template concentration, stability, accuracy, influence of the DNA extraction methods, and the ability to genotype the mixture samples. The performance of the DNATyper™15 system on casework samples was compared with that of two widely used STR amplification kits, Identifiler™ (Applied Biosystems, Carlsbad, CA, USA and PowerPlex 16 ® (Promega, Madison, WI, USA. The conditions for PCR-based DNATyper™15 genotyping were optimized. Contamination from forensically relevant nonhuman DNA was not found to impact genotyping results, and full profiles were generated for all the reactions containing ≥ 0.125 ng of DNA template. No significant difference in performance was observed even after the DNATyper™15 assay components were subjected to 20 freeze-thaw cycles. The performances of DNATyper™15, Identifiler™, and PowerPlex 16 ® were comparable in terms of sensitivity and the ability to genotype the mixed samples and case-type samples, with the assays giving the same genotyping results for all the shared loci. The DNA extraction methods did not affect the performance of any of the systems. Our results demonstrate that the DNATyper™15 system is suitable for genotyping in both forensic DNA database work and case-type samples.

  3. Freeze core sampling to validate time-lapse resistivity monitoring of the hyporheic zone.

    Science.gov (United States)

    Toran, Laura; Hughes, Brian; Nyquist, Jonathan; Ryan, Robert

    2013-01-01

    A freeze core sampler was used to characterize hyporheic zone storage during a stream tracer test. The pore water from the frozen core showed tracer lingered in the hyporheic zone after the tracer had returned to background concentration in collocated well samples. These results confirmed evidence of lingering subsurface tracer seen in time-lapse electrical resistivity tomographs. The pore water exhibited brine exclusion (ion concentrations in ice lower than source water) in a sediment matrix, despite the fast freezing time. Although freeze core sampling provided qualitative evidence of lingering tracer, it proved difficult to quantify tracer concentration because the amount of brine exclusion during freezing could not be accurately determined. Nonetheless, the additional evidence for lingering tracer supports using time-lapse resistivity to detect regions of low fluid mobility within the hyporheic zone that can act as chemically reactive zones of importance in stream health. © 2012, The Author(s). GroundWater © 2012, National Ground Water Association.

  4. Conducting Internet Research With the Transgender Population: Reaching Broad Samples and Collecting Valid Data

    OpenAIRE

    Miner, Michael H.; Bockting, Walter O.; Romine, Rebecca Swinburne; Raman, Sivakumaran

    2011-01-01

    Health research on transgender people has been hampered by the challenges inherent in studying a hard-to-reach, relatively small, and geographically dispersed population. The Internet has the potential to facilitate access to transgender samples large enough to permit examination of the diversity and syndemic health disparities found among this population. In this article, we describe the experiences of a team of investigators using the Internet to study HIV risk behaviors of transgender peop...

  5. Validation of artificial skin equivalents as in vitro testing systems

    Science.gov (United States)

    Schmitt, Robert; Marx, Ulrich; Walles, Heike; Schober, Lena

    2011-03-01

    With the increasing complexity of the chemical composition of pharmaceuticals, cosmetics and everyday substances, the awareness of potential health issues and long term damages for humanoid organs is shifting into focus. Artificial in vitro testing systems play an important role in providing reliable test conditions and replacing precarious animal testing. Especially artificial skin equivalents ASEs are used for a broad spectrum of studies like penetration, irritation and corrosion of substances. One major challenge in tissue engineering is the qualification of each individual ASE as in vitro testing system. Due to biological fluctuations, the stratum corneum hornified layer of some ASEs may not fully develop or other defects might occur. For monitoring these effects we developed an fully automated Optical Coherence Tomography device. Here, we present different methods to characterize and evaluate the quality of the ASEs based on image and data processing of OCT B-scans. By analysing the surface structure, defects, like cuts or tears, are detectable. A further indicator for the quality of the ASE is the morphology of the tissue. This allows to determine if the skin model has reached the final growth state. We found, that OCT is a well suited technology for automatically characterizing artificial skin equivalents and validating the application as testing system.

  6. Testing of a Microfluidic Sampling System for High Temperature Electrochemical MC&A

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Candido [Argonne National Lab. (ANL), Argonne, IL (United States); Nichols, Kevin [Argonne National Lab. (ANL), Argonne, IL (United States)

    2013-11-27

    This report describes the preliminary validation of a high-temperature microfluidic chip system for sampling of electrochemical process salt. Electroanalytical and spectroscopic techniques are attractive candidates for improvement through high-throughput sample analysis via miniaturization. Further, microfluidic chip systems are amenable to micro-scale chemical processing such as rapid, automated sample purification to improve sensor performance. The microfluidic chip was tested to determine the feasibility of the system for high temperature applications and conditions under which microfluidic systems can be used to generate salt droplets at process temperature to support development of material balance and control systems in a used fuel treatment facility. In FY13, the project focused on testing a quartz microchip device with molten salts at near process temperatures. The equipment was installed in glove box and tested up to 400°C using commercial thermal transfer fluids as the carrier phase. Preliminary tests were carried out with a low-melting halide salt to initially characterize the properties of this novel liquid-liquid system and to investigate the operating regimes for inducing droplet flow within candidate carrier fluids. Initial results show that the concept is viable for high temperature sampling but further development is required to optimize the system to operate with process relevant molten salts.

  7. Validation of ten-minute single sample carbon-14 urea breath test for diagnosis of Helicobacter pylori infection

    International Nuclear Information System (INIS)

    Prabakaran, K.; Fernandes, V.; McDonald, J.

    1996-01-01

    Helicobacter pylori infection is traditionally diagnosed by endoscopy followed by gastric biopsy and histologic demonstration of organisms, rapid urease test and culture. The non-invasive carbon-14-urea breath test has been widely accepted now for the diagnosis of this bacterium. This study was aimed to establish and validate normal and abnormal values for an Australian population, for a single sample carbon-14-urea breath test at ten minutes. A dose of 185 kBq was used in order to achieve reasonable counting statistics. The derived values were validated with the results of the rapid urease test. This method has a high sensitivity, specificity and greater patient acceptance, and could be used in many clinical settings as the first modality for the diagnosis of H. pylori infection and for documenting response or cure after antibiotic therapy for eradication. 11 refs., 1 tab., 4 figs

  8. Structural and incremental validity of the Wechsler Adult Intelligence Scale-Fourth Edition with a clinical sample.

    Science.gov (United States)

    Nelson, Jason M; Canivez, Gary L; Watkins, Marley W

    2013-06-01

    Structural and incremental validity of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; Wechsler, 2008a) was examined with a sample of 300 individuals referred for evaluation at a university-based clinic. Confirmatory factor analysis indicated that the WAIS-IV structure was best represented by 4 first-order factors as well as a general intelligence factor in a direct hierarchical model. The general intelligence factor accounted for the most common and total variance among the subtests. Incremental validity analyses indicated that the Full Scale IQ (FSIQ) generally accounted for medium to large portions of academic achievement variance. For all measures of academic achievement, the first-order factors combined accounted for significant achievement variance beyond that accounted for by the FSIQ, but individual factor index scores contributed trivial amounts of achievement variance. Implications for interpreting WAIS-IV results are discussed. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  9. A novel challenge test incorporating irradiation (60Co) of compost sub-samples to validate thermal lethality towards pathogenic bacteria.

    Science.gov (United States)

    Moore, John E; Watabe, Miyuki; Stewart, Andrew; Cherie Millar, B; Rao, Juluri R

    2009-01-01

    Maturing compost heaps normally attaining temperatures ranging from 55 to 65 degrees C is generally regarded to conform to recommended biological risks and sanitation standards for composts stipulated by either EU or US-EPA. Composted products derived from animal sources are further required by EU biohazard safety regulatory legislation that such composts either attain 70 degrees C for over 3h during maturation or via treatment at 70 degrees C for 1h before being considered for dispensation on land. The setting of the upper limit of thermal lethality at 70 degrees C/1h for achieving biosecurity of the animal waste composted products (e.g. pelleted fertilizer formulations) is not properly substantiated by specific validation tests, comprising a 'wipe-out' step (usually via autoclaving) followed by inoculation of a prescribed bacterium, exposure to 70 degrees C/1h and the lethality determined. Pelleted formulations of composts are not amenable for wet methods (autoclaving) for wipe-out sterilization step as this is detrimental to the pellet and compromises sample integrity. This study describes a laboratory method involving the employment of ((60)Co) irradiation 'wipe-out' step to: (a) compost sub-samples drawn from compost formulation heaps and (b) pelleted products derived from composted animal products while determining the thermal lethality of a given time/temperature (70 degrees C/1h) treatment process and by challenging the irradiated sample (not just with one bacterium but), out with 10 potential food-poisoning organisms from the bacterial genera (Campylobacter, Escherichia, Listeria, Salmonella, Yersinia) frequently detected in pig and poultry farm wastes. This challenge test on compost sub-samples can be a useful intervention ploy for 'inspection and validation' technique for composters during the compost maturity process, whose attainment of temperatures of 55-65 degrees C is presumed sufficient for attainment of sanitation. Stringent measures are further

  10. The Arabic Mood and Feelings Questionnaire: psychometrics and validity in a clinical sample.

    Science.gov (United States)

    Tavitian, Lucy; Atwi, Mia; Bawab, Soha; Hariz, Nayla; Zeinoun, Pia; Khani, Munir; Maalouf, Fadi T

    2014-06-01

    The purpose of this study was to provide clinicians in the Arab World with a child and adolescent depression screening tool. Child and parent versions of the Mood and Feelings Questionnaire (CMFQ and PMFQ respectively) were translated to Arabic and administered along with the Strengths and Difficulties Questionnaire (SDQ) to 30 children and adolescents and with mood disorders and 76 children and adolescents with other psychiatric disorders seeking treatment at a child and adolescent psychiatry clinic. DSM-IV diagnoses were generated through clinical interviews by a psychiatrist blinded to self-reports. Internal consistency for both versions was excellent with moderate inter-informant agreement and good convergent validity with the SDQ emotional symptoms subscales on the child and parent forms. The CMFQ and PMFQ significantly differentiated between currently depressed participants and those with other psychiatric disorders. CMFQ scores were a stronger predictor of categorization into depressed and non-depressed groups than the PMFQ. Two modes of cutoffs were calculated with one favoring sensitivity (a score of 26 for the CMFQ and 22 for the PMFQ) and another favoring specificity (a score of 31 for the CMFQ and 28 for the PMFQ).

  11. Hospital Anxiety and Depression Scale (HADS: validation in a Greek general hospital sample

    Directory of Open Access Journals (Sweden)

    Patapis Paulos

    2008-03-01

    Full Text Available Abstract Background The Hospital Anxiety and Depression Scale (HADS has been used in several languages to assess anxiety and depression in general hospital patients with good results. Methods The HADS was administered to 521 participants (275 controls and 246 inpatients and outpatients of the Internal Medicine and Surgical Departments in 'Attikon' General Hospital in Athens. The Beck Depression Inventory (BDI and the State-Trait Anxiety Inventory (STAI were used as 'gold standards' for depression and anxiety respectively. Results The HADS presented high internal consistency; Cronbach's α cofficient was 0.884 (0.829 for anxiety and 0.840 for depression and stability (test-retest intraclass correlation coefficient 0.944. Factor analysis showed a two-factor structure. The HADS showed high concurrent validity; the correlations of the scale and its subscales with the BDI and the STAI were high (0.722 – 0.749. Conclusion The Greek version of HADS showed good psychometric properties and could serve as a useful tool for clinicians to assess anxiety and depression in general hospital patients.

  12. On the validity of within-nuclear-family genetic association analysis in samples of extended families.

    Science.gov (United States)

    Bureau, Alexandre; Duchesne, Thierry

    2015-12-01

    Splitting extended families into their component nuclear families to apply a genetic association method designed for nuclear families is a widespread practice in familial genetic studies. Dependence among genotypes and phenotypes of nuclear families from the same extended family arises because of genetic linkage of the tested marker with a risk variant or because of familial specificity of genetic effects due to gene-environment interaction. This raises concerns about the validity of inference conducted under the assumption of independence of the nuclear families. We indeed prove theoretically that, in a conditional logistic regression analysis applicable to disease cases and their genotyped parents, the naive model-based estimator of the variance of the coefficient estimates underestimates the true variance. However, simulations with realistic effect sizes of risk variants and variation of this effect from family to family reveal that the underestimation is negligible. The simulations also show the greater efficiency of the model-based variance estimator compared to a robust empirical estimator. Our recommendation is therefore, to use the model-based estimator of variance for inference on effects of genetic variants.

  13. An automated blood sampling system used in positron emission tomography

    International Nuclear Information System (INIS)

    Eriksson, L.; Bohm, C.; Kesselberg, M.

    1988-01-01

    Fast dynamic function studies with positron emission tomography (PET), has the potential to give accurate information of physiological functions of the brain. This capability can be realised if the positron camera system accurately quantitates the tracer uptake in the brain with sufficiently high efficiency and in sufficiently short time intervals. However, in addition, the tracer concentration in blood, as a function of time, must be accurately determined. This paper describes and evaluates an automated blood sampling system. Two different detector units are compared. The use of the automated blood sampling system is demonstrated in studies of cerebral blood flow, in studies of the blood-brain barrier transfer of amino acids and of the cerebral oxygen consumption. 5 refs.; 7 figs

  14. Less is more? Assessing the validity of the ICD-11 model of PTSD across multiple trauma samples

    Science.gov (United States)

    Hansen, Maj; Hyland, Philip; Armour, Cherie; Shevlin, Mark; Elklit, Ask

    2015-01-01

    Background In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the symptom profile of posttraumatic stress disorder (PTSD) was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-11) that includes just six symptoms. Objectives and method The objectives of the current study are: 1) to independently investigate the fit of the ICD-11 model of PTSD, and three DSM-5-based models of PTSD, across seven different trauma samples (N=3,746) using confirmatory factor analysis; 2) to assess the concurrent validity of the ICD-11 model of PTSD; and 3) to determine if there are significant differences in diagnostic rates between the ICD-11 guidelines and the DSM-5 criteria. Results The ICD-11 model of PTSD was found to provide excellent model fit in six of the seven trauma samples, and tests of factorial invariance showed that the model performs equally well for males and females. DSM-5 models provided poor fit of the data. Concurrent validity was established as the ICD-11 PTSD factors were all moderately to strongly correlated with scores of depression, anxiety, dissociation, and aggression. Levels of association were similar for ICD-11 and DSM-5 suggesting that explanatory power is not affected due to the limited number of items included in the ICD-11 model. Diagnostic rates were significantly lower according to ICD-11 guidelines compared to the DSM-5 criteria. Conclusions The proposed factor structure of the ICD-11 model of PTSD appears valid across multiple trauma types, possesses good concurrent validity, and is more stringent in terms of diagnosis compared to the DSM-5 criteria. PMID:26450830

  15. The Development and Validation of the Bergen–Yale Sex Addiction Scale With a Large National Sample

    Science.gov (United States)

    Andreassen, Cecilie S.; Pallesen, Ståle; Griffiths, Mark D.; Torsheim, Torbjørn; Sinha, Rajita

    2018-01-01

    The view that problematic excessive sexual behavior (“sex addiction”) is a form of behavioral addiction has gained more credence in recent years, but there is still considerable controversy regarding operationalization of the concept. Furthermore, most previous studies have relied on small clinical samples. The present study presents a new method for assessing sex addiction—the Bergen–Yale Sex Addiction Scale (BYSAS)—based on established addiction components (i.e., salience/craving, mood modification, tolerance, withdrawal, conflict/problems, and relapse/loss of control). Using a cross-sectional survey, the BYSAS was administered to a broad national sample of 23,533 Norwegian adults [aged 16–88 years; mean (± SD) age = 35.8 ± 13.3 years], together with validated measures of the Big Five personality traits, narcissism, self-esteem, and a measure of sexual addictive behavior. Both an exploratory and a confirmatory factor analysis (RMSEA = 0.046, CFI = 0.998, TLI = 0.996) supported a one-factor solution, although a local dependence between two items (Items 1 and 2) was detected. Furthermore, the scale had good internal consistency (Cronbach's α = 0.83). The BYSAS correlated significantly with the reference scale (r = 0.52), and demonstrated similar patterns of convergent and discriminant validity. The BYSAS was positively related to extroversion, neuroticism, intellect/imagination, and narcissism, and negatively related to conscientiousness, agreeableness, and self-esteem. High scores on the BYSAS were more prevalent among those who were men, single, of younger age, and with higher education. The BYSAS is a brief, and psychometrically reliable and valid measure for assessing sex addiction. However, further validation of the BYSAS is needed in other countries and contexts. PMID:29568277

  16. The Development and Validation of the Bergen–Yale Sex Addiction Scale With a Large National Sample

    Directory of Open Access Journals (Sweden)

    Cecilie S. Andreassen

    2018-03-01

    Full Text Available The view that problematic excessive sexual behavior (“sex addiction” is a form of behavioral addiction has gained more credence in recent years, but there is still considerable controversy regarding operationalization of the concept. Furthermore, most previous studies have relied on small clinical samples. The present study presents a new method for assessing sex addiction—the Bergen–Yale Sex Addiction Scale (BYSAS—based on established addiction components (i.e., salience/craving, mood modification, tolerance, withdrawal, conflict/problems, and relapse/loss of control. Using a cross-sectional survey, the BYSAS was administered to a broad national sample of 23,533 Norwegian adults [aged 16–88 years; mean (± SD age = 35.8 ± 13.3 years], together with validated measures of the Big Five personality traits, narcissism, self-esteem, and a measure of sexual addictive behavior. Both an exploratory and a confirmatory factor analysis (RMSEA = 0.046, CFI = 0.998, TLI = 0.996 supported a one-factor solution, although a local dependence between two items (Items 1 and 2 was detected. Furthermore, the scale had good internal consistency (Cronbach's α = 0.83. The BYSAS correlated significantly with the reference scale (r = 0.52, and demonstrated similar patterns of convergent and discriminant validity. The BYSAS was positively related to extroversion, neuroticism, intellect/imagination, and narcissism, and negatively related to conscientiousness, agreeableness, and self-esteem. High scores on the BYSAS were more prevalent among those who were men, single, of younger age, and with higher education. The BYSAS is a brief, and psychometrically reliable and valid measure for assessing sex addiction. However, further validation of the BYSAS is needed in other countries and contexts.

  17. The Development and Validation of the Bergen-Yale Sex Addiction Scale With a Large National Sample.

    Science.gov (United States)

    Andreassen, Cecilie S; Pallesen, Ståle; Griffiths, Mark D; Torsheim, Torbjørn; Sinha, Rajita

    2018-01-01

    The view that problematic excessive sexual behavior ("sex addiction") is a form of behavioral addiction has gained more credence in recent years, but there is still considerable controversy regarding operationalization of the concept. Furthermore, most previous studies have relied on small clinical samples. The present study presents a new method for assessing sex addiction-the Bergen-Yale Sex Addiction Scale (BYSAS)-based on established addiction components (i.e., salience/craving, mood modification, tolerance, withdrawal, conflict/problems, and relapse/loss of control). Using a cross-sectional survey, the BYSAS was administered to a broad national sample of 23,533 Norwegian adults [aged 16-88 years; mean (± SD ) age = 35.8 ± 13.3 years], together with validated measures of the Big Five personality traits, narcissism, self-esteem, and a measure of sexual addictive behavior. Both an exploratory and a confirmatory factor analysis (RMSEA = 0.046, CFI = 0.998, TLI = 0.996) supported a one-factor solution, although a local dependence between two items (Items 1 and 2) was detected. Furthermore, the scale had good internal consistency (Cronbach's α = 0.83). The BYSAS correlated significantly with the reference scale ( r = 0.52), and demonstrated similar patterns of convergent and discriminant validity. The BYSAS was positively related to extroversion, neuroticism, intellect/imagination, and narcissism, and negatively related to conscientiousness, agreeableness, and self-esteem. High scores on the BYSAS were more prevalent among those who were men, single, of younger age, and with higher education. The BYSAS is a brief, and psychometrically reliable and valid measure for assessing sex addiction. However, further validation of the BYSAS is needed in other countries and contexts.

  18. Less is more? Assessing the validity of the ICD-11 model of PTSD across multiple trauma samples

    Directory of Open Access Journals (Sweden)

    Maj Hansen

    2015-10-01

    Full Text Available Background: In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5, the symptom profile of posttraumatic stress disorder (PTSD was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-11 that includes just six symptoms. Objectives and method: The objectives of the current study are: 1 to independently investigate the fit of the ICD-11 model of PTSD, and three DSM-5-based models of PTSD, across seven different trauma samples (N=3,746 using confirmatory factor analysis; 2 to assess the concurrent validity of the ICD-11 model of PTSD; and 3 to determine if there are significant differences in diagnostic rates between the ICD-11 guidelines and the DSM-5 criteria. Results: The ICD-11 model of PTSD was found to provide excellent model fit in six of the seven trauma samples, and tests of factorial invariance showed that the model performs equally well for males and females. DSM-5 models provided poor fit of the data. Concurrent validity was established as the ICD-11 PTSD factors were all moderately to strongly correlated with scores of depression, anxiety, dissociation, and aggression. Levels of association were similar for ICD-11 and DSM-5 suggesting that explanatory power is not affected due to the limited number of items included in the ICD-11 model. Diagnostic rates were significantly lower according to ICD-11 guidelines compared to the DSM-5 criteria. Conclusions: The proposed factor structure of the ICD-11 model of PTSD appears valid across multiple trauma types, possesses good concurrent validity, and is more stringent in terms of diagnosis compared to the DSM-5 criteria.

  19. Less is more? Assessing the validity of the ICD-11 model of PTSD across multiple trauma samples.

    Science.gov (United States)

    Hansen, Maj; Hyland, Philip; Armour, Cherie; Shevlin, Mark; Elklit, Ask

    2015-01-01

    In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the symptom profile of posttraumatic stress disorder (PTSD) was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-11) that includes just six symptoms. The objectives of the current study are: 1) to independently investigate the fit of the ICD-11 model of PTSD, and three DSM-5-based models of PTSD, across seven different trauma samples (N=3,746) using confirmatory factor analysis; 2) to assess the concurrent validity of the ICD-11 model of PTSD; and 3) to determine if there are significant differences in diagnostic rates between the ICD-11 guidelines and the DSM-5 criteria. The ICD-11 model of PTSD was found to provide excellent model fit in six of the seven trauma samples, and tests of factorial invariance showed that the model performs equally well for males and females. DSM-5 models provided poor fit of the data. Concurrent validity was established as the ICD-11 PTSD factors were all moderately to strongly correlated with scores of depression, anxiety, dissociation, and aggression. Levels of association were similar for ICD-11 and DSM-5 suggesting that explanatory power is not affected due to the limited number of items included in the ICD-11 model. Diagnostic rates were significantly lower according to ICD-11 guidelines compared to the DSM-5 criteria. The proposed factor structure of the ICD-11 model of PTSD appears valid across multiple trauma types, possesses good concurrent validity, and is more stringent in terms of diagnosis compared to the DSM-5 criteria.

  20. Algorithm for computing significance levels using the Kolmogorov-Smirnov statistic and valid for both large and small samples

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, S.E.; Fields, D.E.

    1983-10-01

    The KSTEST code presented here is designed to perform the Kolmogorov-Smirnov one-sample test. The code may be used as a stand-alone program or the principal subroutines may be excerpted and used to service other programs. The Kolmogorov-Smirnov one-sample test is a nonparametric goodness-of-fit test. A number of codes to perform this test are in existence, but they suffer from the inability to provide meaningful results in the case of small sample sizes (number of values less than or equal to 80). The KSTEST code overcomes this inadequacy by using two distinct algorithms. If the sample size is greater than 80, an asymptotic series developed by Smirnov is evaluated. If the sample size is 80 or less, a table of values generated by Birnbaum is referenced. Valid results can be obtained from KSTEST when the sample contains from 3 to 300 data points. The program was developed on a Digital Equipment Corporation PDP-10 computer using the FORTRAN-10 language. The code size is approximately 450 card images and the typical CPU execution time is 0.19 s.

  1. Remote sampling system in reprocessing: present and future perspective

    International Nuclear Information System (INIS)

    Garcha, J.S.; Balakrishnan, V.P.; Rao, M.K.

    1990-01-01

    For the process and inventory control of the reprocessing plant operation it is essential to analyse the samples from the various process vessels to assess the plant performance and take corrective action if needed in the operating parameters. In view of the very high radioactive inventory in the plant, these plants are operated remotely behind thick shielding. The liquid sampling also has to be carried out by remote techniques only as no direct approach is feasible. A vacuum assisted air lift method is employed for the purpose of obtaining samples from remotely located process vessels. A brief description of the present technique, the design criteria, various interlocks and manual operations involved during sampling and despatching the same to the analytical laboratory is given in the paper. A design approach for making the sampling system, a fully automated remote operation has been attempted in this paper. Utilisation of custom built robots and dedicated computer for the various operations and interlocks has been visualised to ensure a complete remotised system for the adoption in future plants. (author). 2 figs., 2 tabs

  2. Factorial validity of the Personality Adjective Checklist in a Dutch-speaking sample.

    Science.gov (United States)

    Van den Broeck, Joke; Bastiaansen, Leen; Rossi, Gina; Dierckx, Eva; Mikolajczak-Degrauwe, Kalina; Hofmans, Joeri

    2014-01-01

    We examined the factorial structure of the Dutch version of the Personality Adjective Checklist (PACL-D) in a Belgian sample of 3,012 community-dwelling adults. Exploratory factor analyses revealed a 5-factor structure (Neurotic, Aggressive/Dominant, Introverted vs. Extraverted, Conscientious, and Cooperative), that showed considerable overlap with 3 of the Big Five factors (i.e., Neuroticism, Extraversion, and Conscientiousness). Moreover, the 5-factor structure closely resembled the structure found in the original American PACL and was equivalent across gender and age.

  3. Conducting Internet Research With the Transgender Population: Reaching Broad Samples and Collecting Valid Data.

    Science.gov (United States)

    Miner, Michael H; Bockting, Walter O; Romine, Rebecca Swinburne; Raman, Sivakumaran

    2012-05-01

    Health research on transgender people has been hampered by the challenges inherent in studying a hard-to-reach, relatively small, and geographically dispersed population. The Internet has the potential to facilitate access to transgender samples large enough to permit examination of the diversity and syndemic health disparities found among this population. In this article, we describe the experiences of a team of investigators using the Internet to study HIV risk behaviors of transgender people in the United States. We developed an online instrument, recruited participants exclusively via websites frequented by members of the target population, and collected data using online quantitative survey and qualitative synchronous and asynchronous interview methods. Our experiences indicate that the Internet environment presents the investigator with some unique challenges and that commonly expressed criticisms about Internet research (e.g., lack of generalizable samples, invalid study participants, and multiple participation by the same subject) can be overcome with careful method design, usability testing, and pilot testing. The importance of both usability and pilot testing are described with respect to participant engagement and retention and the quality of data obtained online.

  4. Conducting Internet Research With the Transgender Population: Reaching Broad Samples and Collecting Valid Data

    Science.gov (United States)

    Miner, Michael H.; Bockting, Walter O.; Romine, Rebecca Swinburne; Raman, Sivakumaran

    2013-01-01

    Health research on transgender people has been hampered by the challenges inherent in studying a hard-to-reach, relatively small, and geographically dispersed population. The Internet has the potential to facilitate access to transgender samples large enough to permit examination of the diversity and syndemic health disparities found among this population. In this article, we describe the experiences of a team of investigators using the Internet to study HIV risk behaviors of transgender people in the United States. We developed an online instrument, recruited participants exclusively via websites frequented by members of the target population, and collected data using online quantitative survey and qualitative synchronous and asynchronous interview methods. Our experiences indicate that the Internet environment presents the investigator with some unique challenges and that commonly expressed criticisms about Internet research (e.g., lack of generalizable samples, invalid study participants, and multiple participation by the same subject) can be overcome with careful method design, usability testing, and pilot testing. The importance of both usability and pilot testing are described with respect to participant engagement and retention and the quality of data obtained online. PMID:24031157

  5. Factor Structure, Validity, Reliability and Normalization of the Adult Attention Deficit/Hyperactivity Disorder Scale in Iranian Sample

    Directory of Open Access Journals (Sweden)

    Nafiseh Tabatabaei

    2016-08-01

    Full Text Available Background and Objectives: Researches on attention deficit and hyperactivity disorder indicated that this common disorder would not be resolved with age and continues into adulthood. This study was carried out with the objective of validation and normalization of diagnostic scale of adult attention deficit/hyperactivity disorder scale in Iranian sample. Methods: This study was performed as a psychometric study on the patients (1400 to 1600 cases referred to two psychiatry and neurology clinics in Tehran in the autumn and winter of 2014. Among these patients, 301 persons were selected by purposeful non-random sampling according to the sample size formula based on ratio or two-value variable (patient and non-patient and related questionnaire was administered to them. Cronbach's alpha, Spearman- Brown, and Guttmann’s coefficients was used to evaluate concurrent validity and reliability and exploratory and confirmatory factor analysis in order to assess the construct validity. Results: In this study, Cronbach's alpha of the total scale was 0.88 and for the subscales of inattention, hyperactivity, and impulsivity were 0.82, 0.72, 0.67, respectively. The correlation coefficients between the mentioned scale and adult attention deficit/hyperactivity questionnaire (Wender Utah was obtained 0.59, and between the subscales and the Wender Utah questionnaire, were 0.56, 0.49, and 0.40, respectively, which all three were significant (p<0/01. Confirmatory factor analysis results showed that this scale has three factors and two goodness-of-fit indices. Conclusion: The results of this study revealed that specialists can diagnose and treat the patients using this diagnostic scale.

  6. Development and initial validation of the vaginal penetration cognition questionnaire (VPCQ) in a sample of women with vaginismus and dyspareunia.

    Science.gov (United States)

    Klaassen, Maaike; Ter Kuile, Moniek M

    2009-06-01

    Although the relevance of cognitions has been implicated in the etiology, explanatory models, and treatment of female sexual pain disorders, an instrument that assesses vaginal penetration cognitions is nonexistent. The aim of this study was to develop and to investigate the psychometric properties of the Vaginal Penetration Cognition Questionnaire (VPCQ). The VPCQ was explicitly designed to assess cognitions regarding vaginal penetration in women with vaginismus and dyspareunia. A sample of 247 Dutch women with a female sexual dysfunction (FSD; 122 women with lifelong vaginismus and 125 women with dyspareunia) and 117 women without sexual complaints completed the questionnaire. Factor analyses were only conducted in the sample of women with FSD. Validation measures were conducted in both women with and without FSD. All women completed the VPCQ and several additional questions regarding biographic and complaint characteristics. Conduction of factor analyses yielded five subscales regarding cognitions about vaginal penetration: "control cognitions,"catastrophic and pain cognitions,"self-image cognitions,"positive cognitions," and "genital incompatibility cognitions." Reliability of these five VPCQ subscales ranged from 0.70 to 0.83, and the test-retest correlations were satisfactory. The five VPCQ subscales were reasonably stable across demographic variables and demonstrated good discriminant validity. All five subscales were able to detect significant differences between women with and without FSD. Additionally, the four subscales of the VPCQ concerning negative cognitions demonstrated the ability to differentiate between the two samples of women with FSD. Women with lifelong vaginismus reported lower levels of perceived penetration control and higher levels of catastrophic and pain cognitions, negative self-image cognitions, and genital incompatibility cognitions, when compared with women with dyspareunia. The present study indicates that the VPCQ is a valid and

  7. Computational Design and Experimental Validation of New Thermal Barrier Systems

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Shengmin; Yang, Shizhong; Khosravi, Ebrahim

    2011-12-31

    This project (10/01/2010-9/30/2013), “Computational Design and Experimental Validation of New Thermal Barrier Systems”, originates from Louisiana State University (LSU) Mechanical Engineering Department and Southern University (SU) Department of Computer Science. This proposal will directly support the technical goals specified in DE-FOA-0000248, Topic Area 3: Turbine Materials, by addressing key technologies needed to enable the development of advanced turbines and turbine-based systems that will operate safely and efficiently using coal-derived synthesis gases. We will develop novel molecular dynamics method to improve the efficiency of simulation on novel TBC materials; we will perform high performance computing (HPC) on complex TBC structures to screen the most promising TBC compositions; we will perform material characterizations and oxidation/corrosion tests; and we will demonstrate our new Thermal barrier coating (TBC) systems experimentally under Integrated gasification combined cycle (IGCC) environments. The durability of the coating will be examined using the proposed High Temperature/High Pressure Durability Test Rig under real syngas product compositions.

  8. System verification and validation report for the TMAD code

    International Nuclear Information System (INIS)

    Finfrock, S.H.

    1995-01-01

    This document serves as the Verification and Validation Report for the TMAD code system, which includes the TMAD code and the LIBMAKR Code. The TMAD code was commissioned to facilitate the interpretation of moisture probe measurements in the Hanford Site waste tanks. In principle, the code is an interpolation routine that acts over a library of benchmark data based on two independent variables, typically anomaly size and moisture content. Two additional variables, anomaly type and detector type, can also be considered independent variables, but no interpolation is done over them. The dependent variable is detector response. The intent is to provide the code with measured detector responses from two or more detectors. The code will then interrogate (and interpolate upon) the benchmark data library and find the anomaly-type/anomaly-size/moisture-content combination that provides the closest match to the measured data. The primary purpose of this document is to provide the results of the system testing and the conclusions based thereon. The results of the testing process are documented in the body of the report. Appendix A gives the test plan, including test procedures, used in conducting the tests. Appendix B lists the input data required to conduct the tests, and Appendices C and 0 list the numerical results of the tests

  9. Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography.

    Science.gov (United States)

    Loudiki, A; Boumya, W; Hammani, H; Nasrellah, H; El Bouabi, Y; Zeroual, M; Farahi, A; Lahrich, S; Hnini, K; Achak, M; Bakasse, M; El Mhammedi, M A

    2016-12-01

    The electrochemical detection of ibuprofen has been studied on Palladium-Montmorillonite (Mt) modified carbon paste electrode using differential pulse voltammetry. The optimization of the modifier preparation and the instrumental parameters was investigated. The results indicate that ibuprofen oxidation was favored in the presence of Pd-PdO particles. The quantitative determination of ibuprofen was statistically analyzed and validated using HPLC method. The detection and quantification limits, specificity and precision were found to be acceptable. Finally, the developed method was successfully applied for ibuprofen determination in human blood samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. NordVal: A Nordic system for validation of alternative microbiological methods

    DEFF Research Database (Denmark)

    Qvist, Sven

    2007-01-01

    NordVal was created in 1999 by the Nordic Committee of Senior Officials for Food Issues under the Nordic Council of Ministers. The Committee adopted the following objective for NordVal: NordVal evaluates the performance and field of application of alternative microbiological methods. This includes...... analyses of food, water, feed, animal faeces and food environmental samples in the Nordic countries. NordVal is managed by a steering group, which is appointed by the National Food Administrations in Denmark, Finland, Iceland, Norway and Sweden. The background for creation of NordVal was a Danish...... validation system (DanVal) established in 1995 to cope with a need to validate alternative methods to be used in the Danish Salmonella Action Program. The program attracted considerable attention in the other Nordic countries. NordVal has elaborated a number of documents, which describe the requirements...

  11. Image Quality Modeling and Characterization of Nyquist Sampled Framing Systems with Operational Considerations for Remote Sensing

    Science.gov (United States)

    Garma, Rey Jan D.

    The trade between detector and optics performance is often conveyed through the Q metric, which is defined as the ratio of detector sampling frequency and optical cutoff frequency. Historically sensors have operated at Q ≈ 1, which introduces aliasing but increases the system modulation transfer function (MTF) and signal-to-noise ratio (SNR). Though mathematically suboptimal, such designs have been operationally ideal when considering system parameters such as pointing stability and detector performance. Substantial advances in read noise and quantum efficiency of modern detectors may compensate for the negative aspects associated with balancing detector/optics performance, presenting an opportunity to revisit the potential for implementing Nyquist-sampled (Q ≈ 2) sensors. A digital image chain simulation is developed and validated against a laboratory testbed using objective and subjective assessments. Objective assessments are accomplished by comparison of the modeled MTF and measurements from slant-edge photographs. Subjective assessments are carried out by performing a psychophysical study where subjects are asked to rate simulation and testbed imagery against a DeltaNIIRS scale with the aid of a marker set. Using the validated model, additional test cases are simulated to study the effects of increased detector sampling on image quality with operational considerations. First, a factorial experiment using Q-sampling, pointing stability, integration time, and detector performance is conducted to measure the main effects and interactions of each on the response variable, DeltaNIIRS. To assess the fidelity of current models, variants of the General Image Quality Equation (GIQE) are evaluated against subject-provided ratings and two modified GIQE versions are proposed. Finally, using the validated simulation and modified IQE, trades are conducted to ascertain the feasibility of implementing Q ≈ 2 designs in future systems.

  12. Multicenter validation of PCR-based method for detection of Salmonella in chicken and pig samples

    DEFF Research Database (Denmark)

    Malorny, B.; Cook, N.; D'Agostino, M.

    2004-01-01

    As part of a standardization project, an interlaboratory trial including 15 laboratories from 13 European countries was conducted to evaluate the performance of a noproprietary polymerase chain reaction (PCR)-based method for the detection of Salmonella on artificially contaminated chicken rinse...... or positive. Outlier results caused, for example, by gross departures from the experimental protocol, were omitted from the analysis. For both the chicken rinse and the pig swab samples, the diagnostic sensitivity was 100%, with 100% accordance (repeatability) and concordance (reproducibility). The diagnostic...... specificity was 80.1% (with 85.7% accordance and 67.5% concordance) for chicken rinse, and 91.7% (with 100% accordance and 83.3% concordance) for pig swab. Thus, the interlaboratory variation due to personnel, reagents, thermal cyclers, etc., did not affect the performance of the method, which...

  13. Solar System Samples for Research, Education, and Public Outreach

    Science.gov (United States)

    Allen, J.; Luckey, M.; McInturff, B.; Kascak, A.; Tobola, K.; Galindo, C.; Allen, C.

    2011-01-01

    In the next two years, during the NASA Year of the Solar System, spacecraft from NASA and our international partners will; encounter a comet, orbit asteroid 4 Vesta, continue to explore Mars with rovers, and launch robotic explorers to the Moon and Mars. We have pieces of all these worlds in our laboratories, and their continued study provides incredibly valuable "ground truth" to complement space exploration missions. Extensive information about these unique materials, as well as actual lunar samples and meteorites, are available for display and education. The Johnson Space Center (JSC) has the unique responsibility to curate NASA's extraterrestrial samples from past and future missions. Curation includes documentation, preservation, preparation, and distribution of samples for research, education, and public outreach.

  14. Neuro-genetic system for optimization of GMI samples sensitivity.

    Science.gov (United States)

    Pitta Botelho, A C O; Vellasco, M M B R; Hall Barbosa, C R; Costa Silva, E

    2016-03-01

    Magnetic sensors are largely used in several engineering areas. Among them, magnetic sensors based on the Giant Magnetoimpedance (GMI) effect are a new family of magnetic sensing devices that have a huge potential for applications involving measurements of ultra-weak magnetic fields. The sensitivity of magnetometers is directly associated with the sensitivity of their sensing elements. The GMI effect is characterized by a large variation of the impedance (magnitude and phase) of a ferromagnetic sample, when subjected to a magnetic field. Recent studies have shown that phase-based GMI magnetometers have the potential to increase the sensitivity by about 100 times. The sensitivity of GMI samples depends on several parameters, such as sample length, external magnetic field, DC level and frequency of the excitation current. However, this dependency is yet to be sufficiently well-modeled in quantitative terms. So, the search for the set of parameters that optimizes the samples sensitivity is usually empirical and very time consuming. This paper deals with this problem by proposing a new neuro-genetic system aimed at maximizing the impedance phase sensitivity of GMI samples. A Multi-Layer Perceptron (MLP) Neural Network is used to model the impedance phase and a Genetic Algorithm uses the information provided by the neural network to determine which set of parameters maximizes the impedance phase sensitivity. The results obtained with a data set composed of four different GMI sample lengths demonstrate that the neuro-genetic system is able to correctly and automatically determine the set of conditioning parameters responsible for maximizing their phase sensitivities. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Improved mixing and sampling systems for vitrification melter feeds

    International Nuclear Information System (INIS)

    Ebadian, M.A.

    1998-01-01

    This report summarizes the methods used and results obtained during the progress of the study of waste slurry mixing and sampling systems during fiscal year 1977 (FY97) at the Hemispheric Center for Environmental Technology (HCET) at Florida International University (FIU). The objective of this work is to determine optimal mixing configurations and operating conditions as well as improved sampling technology for defense waste processing facility (DWPF) waste melter feeds at US Department of Energy (DOE) sites. Most of the research on this project was performed experimentally by using a tank mixing configuration with different rotating impellers. The slurry simulants for the experiments were prepared in-house based on the properties of the DOE sites' typical waste slurries. A sampling system was designed to withdraw slurry from the mixing tank. To obtain insight into the waste mixing process, the slurry flow in the mixing tank was also simulated numerically by applying computational fluid dynamics (CFD) methods. The major parameters investigated in both the experimental and numerical studies included power consumption of mixer, mixing time to reach slurry uniformity, slurry type, solids concentration, impeller type, impeller size, impeller rotating speed, sampling tube size, and sampling velocities. Application of the results to the DWPF melter feed preparation process will enhance and modify the technical base for designing slurry transportation equipment and pipeline systems. These results will also serve as an important reference for improving waste slurry mixing performance and melter operating conditions. These factors will contribute to an increase in the capability of the vitrification process and the quality of the waste glass

  16. Verification and Validation of Embedded Knowledge-Based Software Systems

    National Research Council Canada - National Science Library

    Santos, Eugene

    1999-01-01

    .... We pursued this by carefully examining the nature of uncertainty and information semantics and developing intelligent tools for verification and validation that provides assistance to the subject...

  17. MarsVac: Pneumatic Sampling System for Planetary Exploration

    Science.gov (United States)

    Zacny, K.; Mungas, G.; Chu, P.; Craft, J.; Davis, K.

    2008-12-01

    We are proposing a Mars Sample Return scheme whereby a sample of regolith is acquired directly into a Mars Ascent Vehicle using a pneumatic system. Unlike prior developments that used suction to collect fines, the proposed system uses positive pressure to move the regolith. We envisage 3 pneumatic tubes to be embedded inside the 3 legs of the lander. Upon landing, the legs will burry themselves into the regolith and the tubes will fill up with regolith. With one puff of gas, the regolith can be lifted into a sampling chamber onboard of the Mars Ascent Vehicle. An additional chamber can be opened to acquire atmospheric gas and dust. The entire MSR will require 1) an actuator to open/close sampling chamber and 2) a valve to open gas cylinder. In the most recent study related to lunar excavation and funded under the NASA SBIR program we have shown that it is possible lift over 3000 grams of soil with only 1 gram of gas at 1atm. Tests conducted under Mars atmospheric pressure conditions (5 torr). In September of 2008, we will be performing tests at 1/6thg (Moon) and 1/3g (Mars) to determine mass lifting efficiencies in reduced gravities.

  18. Estimating rare events in biochemical systems using conditional sampling

    Science.gov (United States)

    Sundar, V. S.

    2017-01-01

    The paper focuses on development of variance reduction strategies to estimate rare events in biochemical systems. Obtaining this probability using brute force Monte Carlo simulations in conjunction with the stochastic simulation algorithm (Gillespie's method) is computationally prohibitive. To circumvent this, important sampling tools such as the weighted stochastic simulation algorithm and the doubly weighted stochastic simulation algorithm have been proposed. However, these strategies require an additional step of determining the important region to sample from, which is not straightforward for most of the problems. In this paper, we apply the subset simulation method, developed as a variance reduction tool in the context of structural engineering, to the problem of rare event estimation in biochemical systems. The main idea is that the rare event probability is expressed as a product of more frequent conditional probabilities. These conditional probabilities are estimated with high accuracy using Monte Carlo simulations, specifically the Markov chain Monte Carlo method with the modified Metropolis-Hastings algorithm. Generating sample realizations of the state vector using the stochastic simulation algorithm is viewed as mapping the discrete-state continuous-time random process to the standard normal random variable vector. This viewpoint opens up the possibility of applying more sophisticated and efficient sampling schemes developed elsewhere to problems in stochastic chemical kinetics. The results obtained using the subset simulation method are compared with existing variance reduction strategies for a few benchmark problems, and a satisfactory improvement in computational time is demonstrated.

  19. Resonance ionization mass spectrometry system for measurement of environmental samples

    International Nuclear Information System (INIS)

    Pibida, L.; McMahon, C.A.; Noertershaeuser, W.; Bushaw, B.A.

    2002-01-01

    A resonance ionization mass spectrometry (RIMS) system has been developed at the National Institute of Standards and Technology (NIST) for sensitive and selective determination of radio-cesium in the environment. The overall efficiency was determined to be 4x10-7 with a combined (laser and mass spectrometer) selectivity of 108 for both 135Cs and 137Cs with respect to 133Cs. RIMS isotopic ratio measurements of 135Cs/ 137Cs were performed on a nuclear fuel burn-up sample and compared to measurements on a similar system at Pacific Northwest National Laboratory (PNNL) and to conventional thermal ionization mass spectrometry (TIMS). Results of preliminary RIMS investigations on a freshwater lake sediment sample are also discussed

  20. Validation of the Reading the Mind in the Eyes Test in a healthy Spanish sample and women with anorexia nervosa.

    Science.gov (United States)

    Redondo, Iratxe; Herrero-Fernández, David

    2018-04-11

    The aim of this study was to build a Spanish version of the Reading the Mind in the Eyes Test (RMET) including limited time of response and an integrated glossary, and to test its validity. A total of 433 university students (121 men and 350 women) and 38 anorexic women completed the RMET and other related measures of empathy and alexithymia. The results of the Parallel Analysis suggested a unidimensional structure for 19 items, which was verified through a Confirmatory Factor Analysis. Similarly to other research, this factor had a low reliability (α = .56, ρ = .59); however, regarding validity, the total score of the instrument showed positive correlations with empathy and negatives with alexithymia. Furthermore, healthy females were superior to males in RMET, and to anorexic women; but no significant differences appeared between healthy men and the anorexic group. This study confirms the validity of the test and permits a relatively short and inexpensive means of administration in large samples of adults. Besides, it suggests the necessity of assessing and treating the theory of mind in anorexic women.

  1. The Stigma Resistance Scale: A multi-sample validation of a new instrument to assess mental illness stigma resistance.

    Science.gov (United States)

    Firmin, Ruth L; Lysaker, Paul H; McGrew, John H; Minor, Kyle S; Luther, Lauren; Salyers, Michelle P

    2017-12-01

    Although associated with key recovery outcomes, stigma resistance remains under-studied largely due to limitations of existing measures. This study developed and validated a new measure of stigma resistance. Preliminary items, derived from qualitative interviews of people with lived experience, were pilot tested online with people self-reporting a mental illness diagnosis (n = 489). Best performing items were selected, and the refined measure was administered to an independent sample of people with mental illness at two state mental health consumer recovery conferences (n = 202). Confirmatory factor analyses (CFA) guided by theory were used to test item fit, correlations between the refined stigma resistance measure and theoretically relevant measures were examined for validity, and test-retest correlations of a subsample were examined for stability. CFA demonstrated strong fit for a 5-factor model. The final 20-item measure demonstrated good internal consistency for each of the 5 subscales, adequate test-retest reliability at 3 weeks, and strong construct validity (i.e., positive associations with quality of life, recovery, and self-efficacy, and negative associations with overall symptoms, defeatist beliefs, and self-stigma). The new measure offers a more reliable and nuanced assessment of stigma resistance. It may afford greater personalization of interventions targeting stigma resistance. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Validation of a Spanish translation of the CLOX for use in Hispanic samples: the Hispanic EPESE study.

    Science.gov (United States)

    Royall, Donald R; Espino, David V; Polk, Marsha J; Verdeja, Regina; Vale, Sandra; Gonzales, Hector; Palmer, Raymond R; Markides, Kyriakos P

    2003-02-01

    Clock drawing tests (CDT) appear to be less vulnerable to linguistic, cultural, or educational bias than traditional dementia screening instruments. We investigated a Spanish language translation of CLOX: an executive CDT, in a community sample of Hispanic elders. In-home CLOX evaluations of 1309 Mexican-American elders were reviewed. Both CLOX1 (an executive CDT) and CLOX2 (a constructional CDT) showed good internal consistency (Chronbach's alpha; both alpha = 0.82). Cultural-demographic variables had little effect on CLOX scores. Although language had a significant effect on CLOX1 failure rates, this was not mediated by age, education, acculturation or income. These results suggest that the Spanish CLOX can be validly administered to community-based Hispanic elder samples regardless of education or acculturation. Copyright 2003 John Wiley & Sons, Ltd.

  3. Safety analysis report for packaging (onsite) sample pig transport system

    International Nuclear Information System (INIS)

    MCCOY, J.C.

    1999-01-01

    This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document

  4. Safety analysis report for packaging (onsite) sample pig transport system

    Energy Technology Data Exchange (ETDEWEB)

    MCCOY, J.C.

    1999-03-16

    This Safety Analysis Report for Packaging (SARP) provides a technical evaluation of the Sample Pig Transport System as compared to the requirements of the U.S. Department of Energy, Richland Operations Office (RL) Order 5480.1, Change 1, Chapter III. The evaluation concludes that the package is acceptable for the onsite transport of Type B, fissile excepted radioactive materials when used in accordance with this document.

  5. Sampling Transition Pathways in Highly Correlated Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chandler, David

    2004-10-20

    This research grant supported my group's efforts to apply and extend the method of transition path sampling that we invented during the late 1990s. This methodology is based upon a statistical mechanics of trajectory space. Traditional statistical mechanics focuses on state space, and with it, one can use Monte Carlo methods to facilitate importance sampling of states. With our formulation of a statistical mechanics of trajectory space, we have succeeded at creating algorithms by which importance sampling can be done for dynamical processes. In particular, we are able to study rare but important events without prior knowledge of transition states or mechanisms. In perhaps the most impressive application of transition path sampling, my group combined forces with Michele Parrinello and his coworkers to unravel the dynamics of auto ionization of water [5]. This dynamics is the fundamental kinetic step of pH. Other applications concern nature of dynamics far from equilibrium [1, 7], nucleation processes [2], cluster isomerization, melting and dissociation [3, 6], and molecular motors [10]. Research groups throughout the world are adopting transition path sampling. In part this has been the result of our efforts to provide pedagogical presentations of the technique [4, 8, 9], as well as providing new procedures for interpreting trajectories of complex systems [11].

  6. Elaboration, validation and standardization of the five to fifteen (FTF) questionnaire in a Danish population sample.

    Science.gov (United States)

    Lambek, Rikke; Trillingsgaard, Anegen

    2015-03-01

    The five to fifteen (FTF) is a parent questionnaire developed to assess ADHD, its common comorbid conditions and associated problems in children and adolescents. The present study examined (1) the psychometric properties of scores on the new teacher version of the FTF, (2) competing models of the FTF subdomain structure and (3) the psychometric properties and utility of scores on the newly developed FTF impact questions. Parents (n=4258) and teachers (n=1298) of Danish children and adolescents (ages 5 to 17 years), selected using simple random sampling, completed the FTF. In the largest study of the FTF to date, parent and teacher scores had acceptable psychometric properties. The FTF subdomains were organized into six domains labelled cognitive skills, motor/perception, emotion/socialization/behaviour, attention, literacy skills and activity control and analysis of these domains may provide additional information when applying the FTF in the future. The impact questions yielded information above and beyond that provided by symptom count alone and appeared to increase the ability of the FTF to identify at risk children and adolescents. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Development and Validation of Chronopotentiometric Method for Imidacloprid Determination in Pesticide Formulations and River Water Samples

    Directory of Open Access Journals (Sweden)

    Ana Đurović

    2016-01-01

    Full Text Available A new electrochemical method for determination of imidacloprid using chronopotentiometry on thin film mercury and glassy carbon electrode was presented. The most important experimental parameters of chronopotentiometry were examined and optimized with respect to imidacloprid analytical signal. Imidacloprid provided well-defined reduction peak in Britton-Robinson buffer on thin film mercury electrode at −1.0 V (versus Ag/AgCl (KCl, 3.5 mol/L and on glassy carbon electrode at −1.2 V (versus Ag/AgCl (KCl, 3.5 mol/L. The reduction time was linearly proportional to concentrations from 0.8 to 30.0 mg/L on thin film mercury electrode and from 7.0 to 70.0 mg/L on glassy carbon electrode. The detection limits were 0.17 mg/L and 0.93 mg/L for thin film mercury and glassy carbon electrode, respectively. The estimation of method precision as a function of repeatability and reproducibility showed relative standard deviations values lower than 3.73%. Recovery values from 97.3 to 98.1% confirmed the accuracy of the proposed method, while the constancy of the transition time with deliberated small changes in the experimental parameters indicated a very good robustness. A minor influence of possible interfering compounds proved good selectivity of the method. Developed method was applied for imidacloprid determination in commercial pesticide formulations and river water samples.

  8. Emotion Recognition Ability Test Using JACFEE Photos: A Validity/Reliability Study of a War Veterans' Sample and Their Offspring.

    Science.gov (United States)

    Castro-Vale, Ivone; Severo, Milton; Carvalho, Davide; Mota-Cardoso, Rui

    2015-01-01

    Emotion recognition is very important for social interaction. Several mental disorders influence facial emotion recognition. War veterans and their offspring are subject to an increased risk of developing psychopathology. Emotion recognition is an important aspect that needs to be addressed in this population. To our knowledge, no test exists that is validated for use with war veterans and their offspring. The current study aimed to validate the JACFEE photo set to study facial emotion recognition in war veterans and their offspring. The JACFEE photo set was presented to 135 participants, comprised of 62 male war veterans and 73 war veterans' offspring. The participants identified the facial emotion presented from amongst the possible seven emotions that were tested for: anger, contempt, disgust, fear, happiness, sadness, and surprise. A loglinear model was used to evaluate whether the agreement between the intended and the chosen emotions was higher than the expected. Overall agreement between chosen and intended emotions was 76.3% (Cohen kappa = 0.72). The agreement ranged from 63% (sadness expressions) to 91% (happiness expressions). The reliability by emotion ranged from 0.617 to 0.843 and the overall JACFEE photo set Cronbach alpha was 0.911. The offspring showed higher agreement when compared with the veterans (RR: 41.52 vs 12.12, p < 0.001), which confirms the construct validity of the test. The JACFEE set of photos showed good validity and reliability indices, which makes it an adequate instrument for researching emotion recognition ability in the study sample of war veterans and their respective offspring.

  9. Emotion Recognition Ability Test Using JACFEE Photos: A Validity/Reliability Study of a War Veterans' Sample and Their Offspring.

    Directory of Open Access Journals (Sweden)

    Ivone Castro-Vale

    Full Text Available Emotion recognition is very important for social interaction. Several mental disorders influence facial emotion recognition. War veterans and their offspring are subject to an increased risk of developing psychopathology. Emotion recognition is an important aspect that needs to be addressed in this population. To our knowledge, no test exists that is validated for use with war veterans and their offspring. The current study aimed to validate the JACFEE photo set to study facial emotion recognition in war veterans and their offspring. The JACFEE photo set was presented to 135 participants, comprised of 62 male war veterans and 73 war veterans' offspring. The participants identified the facial emotion presented from amongst the possible seven emotions that were tested for: anger, contempt, disgust, fear, happiness, sadness, and surprise. A loglinear model was used to evaluate whether the agreement between the intended and the chosen emotions was higher than the expected. Overall agreement between chosen and intended emotions was 76.3% (Cohen kappa = 0.72. The agreement ranged from 63% (sadness expressions to 91% (happiness expressions. The reliability by emotion ranged from 0.617 to 0.843 and the overall JACFEE photo set Cronbach alpha was 0.911. The offspring showed higher agreement when compared with the veterans (RR: 41.52 vs 12.12, p < 0.001, which confirms the construct validity of the test. The JACFEE set of photos showed good validity and reliability indices, which makes it an adequate instrument for researching emotion recognition ability in the study sample of war veterans and their respective offspring.

  10. Analytical Validation of a New Enzymatic and Automatable Method for d-Xylose Measurement in Human Urine Samples

    Directory of Open Access Journals (Sweden)

    Israel Sánchez-Moreno

    2017-01-01

    Full Text Available Hypolactasia, or intestinal lactase deficiency, affects more than half of the world population. Currently, xylose quantification in urine after gaxilose oral administration for the noninvasive diagnosis of hypolactasia is performed with the hand-operated nonautomatable phloroglucinol reaction. This work demonstrates that a new enzymatic xylose quantification method, based on the activity of xylose dehydrogenase from Caulobacter crescentus, represents an excellent alternative to the manual phloroglucinol reaction. The new method is automatable and facilitates the use of the gaxilose test for hypolactasia diagnosis in the clinical practice. The analytical validation of the new technique was performed in three different autoanalyzers, using buffer or urine samples spiked with different xylose concentrations. For the comparison between the phloroglucinol and the enzymatic assays, 224 urine samples of patients to whom the gaxilose test had been prescribed were assayed by both methods. A mean bias of −16.08 mg of xylose was observed when comparing the results obtained by both techniques. After adjusting the cut-off of the enzymatic method to 19.18 mg of xylose, the Kappa coefficient was found to be 0.9531, indicating an excellent level of agreement between both analytical procedures. This new assay represents the first automatable enzymatic technique validated for xylose quantification in urine.

  11. Validation of a Spanish translation of the Gratitude Questionnaire (GQ-6) with a Chilean sample of adults and high schoolers.

    Science.gov (United States)

    Langer, Álvaro I; Ulloa, Valentina G; Aguilar-Parra, José M; Araya-Véliz, Claudio; Brito, Gonzalo

    2016-03-31

    Recent studies have associated positive emotions with several variables such as learning, coping strategies or assertive behaviour. The concept of gratitude has been specifically defined as a tendency to recognise and respond to people or situations with grateful emotion. Unfortunately in Latin America, no validated measures of gratitude on different populations are available. The aim of this study was to analyse the psychometric properties of the Gratitude Questionnaire (GQ-6) in two Chilean samples. Two studies were conducted: the first with 668 high school adolescents (390 women and 278 men, with ages ranging between 12 and 20, and a mean age 15.54 ± 1.22) and the second with 331 adults (231 women and 100 men, with an average age of 37.59 ± 12.6). An analysis of the psychometric properties of the GQ-6 scale to determine the validity and reliability of the instrument in Chilean adolescents and adults was performed. Bivariate correlations, multiple regression analyses, exploratory factor analysis (EFA) and Monte Carlo simulations were carried out. Finally, a confirmatory factor analysis (CFA) was performed. A single-factor solution was found in both studies, a 5 item version for the adolescents and 6 items for adults. This factorial solution was invariant across genders. Reliability of the GQ was adequate in both samples (using Cronbach's alpha coefficient). In addition convergent and discriminate validity were assessed. Additionally, a negative correlation between the GQ-5 and depression in adolescents and a positive correlation between the GQ-6 and happiness in adults was found. The GQ is a suitable measure for evaluating a person's disposition toward gratitude in Chilean adolescents and adults. This instrument may contribute to the advancement of the study of positive emotions in Latin America.

  12. Reliability and Validity of the Multidimensional Locus of Control IPC Scale in a Sample of 3668 Greek Educators

    Directory of Open Access Journals (Sweden)

    Ntina Kourmousi

    2015-11-01

    Full Text Available The Multidimensional Locus of Control IPC Scale (IPC LOC Scale is an instrument for assessing the locus of control on adults. The aim of the present study is to translate the IPC LOC Scale and evaluate its reliability and validity in a sample of Greek teachers. Data were collected from a nationwide sample of 3668 educators of all levels and specialties. The Cronbach’s alpha coefficient was used to determine the internal consistency reliability. A confirmatory factor analysis (CFA was conducted in order to test the construct validity of the questionnaire. Validity was further examined by investigating the correlation of the IPC LOC Scale with the Rosenberg self-esteem scale (RSES and its association with several demographic and work-related data. Internal consistency reliability was satisfactory with a Cronbach’s alpha above 0.70 for all LOC dimensions. CFA confirmed that the items composing the three subscales of the IPC LOC Scale measure the same construct. Also, the root mean square error of approximation (RMSEA, the comparative fit index (CFI and the goodness of fit index (GFI values were 0.053, 0.951, and 0.937, respectively for the three-factor model, further confirming the manufacturer’s theory for the three latent variables, Internality, Powerful Others, and Chance. Intercorrelations and correlation coefficients between the IPC LOC Scale and the RSES were significant, while age and sex differences were also found. The Greek version of the IPC LOC Scale was found to have satisfactory psychometric properties and could be used to evaluate the locus of control in Greek teachers.

  13. CFD analysis for offshore systems: validation and applications

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Daniel Fonseca de Carvalho e; Pagot, Paulo Roberto [Centro de Pesquisas da PETROBRAS (CENPES), Rio de janeiro, RJ (Brazil). Gerencia de Tecnologia de Engenharia Oceanica], E-mails: danielfc@petrobras.com.br, pagot@petrobras.com.br

    2011-04-15

    The Ocean Engineering group in the PETROBRAS Research Center develops and applies multidisciplinary simulation tools for several engineering problems mainly related to offshore systems. Recently, there have been many different cases where Computational Fluid Dynamics (CFD) has been successfully employed. This study presents a collection of cases where CFD simulations were validated against experimental data and directly used to facilitate solutions for practical problems. Case 01 calculated the maritime current loads on an FPSO and investigated the influence of appendices such as bilge keels and rudders on the near flow field. Similarly, Case 02 extends this procedure to the identification of wind loads. Case 03 calculates the hydrodynamic forces on a torpedo anchor during its installation. The simulation results coupled with a simplified dynamic model facilitates the directional stability of different torpedo models to be evaluated. A whole FPSO topside geometry is modeled in Case 04, which investigates the flow pattern near the FPSO Helideck. The simulation velocity and turbulence profiles were compared to wind tunnel measurements. These summarized cases show how CFD tools can be advantageously applied to solve many practical problems. All these simulations were performed using ANSYS CFX. (author)

  14. Development, validation and accreditation of a method for the determination of Pb, Cd, Cu and As in seafood and fish feed samples.

    Science.gov (United States)

    Psoma, A K; Pasias, I N; Rousis, N I; Barkonikos, K A; Thomaidis, N S

    2014-05-15

    A rapid, sensitive, accurate and precise method for the determination of Pb, Cd, As and Cu in seafood and fish feed samples by Simultaneous Electrothermal Atomic Absorption Spectrometry was developed in regard to Council Directive 333/2007EC and ISO/IEC 17025 (2005). Different approaches were investigated in order to shorten the analysis time, always taking into account the sensitivity. For method validation, precision (repeatability and reproducibility) and accuracy by addition recovery tests have been assessed as performance criteria. The expanded uncertainties based on the Eurachem/Citac Guidelines were calculated. The method was accredited by the Hellenic Accreditation System and it was applied for an 8 years study in seafood (n=202) and fish feeds (n=275) from the Greek market. The annual and seasonal variation of the elemental content and correlation among the elemental content in fish feeds and the respective fish samples were also accomplished. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. Development and Validation of a Real-Time PCR Assay for Rapid Detection of Candida auris from Surveillance Samples.

    Science.gov (United States)

    Leach, L; Zhu, Y; Chaturvedi, S

    2018-02-01

    Candida auris is an emerging multidrug-resistant yeast causing invasive health care-associated infection with high mortality worldwide. Rapid identification of C. auris is of primary importance for the implementation of public health measures to control the spread of infection. To achieve these goals, we developed and validated a TaqMan-based real-time PCR assay targeting the internal transcribed spacer 2 ( ITS 2) region of the ribosomal gene. The assay was highly specific, reproducible, and sensitive, with the detection limit of 1 C. auris CFU/PCR. The performance of the C. auris real-time PCR assay was evaluated by using 623 surveillance samples, including 365 patient swabs and 258 environmental sponges. Real-time PCR yielded positive results from 49 swab and 58 sponge samples, with 89% and 100% clinical sensitivity with regard to their respective culture-positive results. The real-time PCR also detected C. auris DNA from 1% and 12% of swab and sponge samples with culture-negative results, indicating the presence of dead or culture-impaired C. auris The real-time PCR yielded results within 4 h of sample processing, compared to 4 to 14 days for culture, reducing turnaround time significantly. The new real-time PCR assay allows for accurate and rapid screening of C. auris and can increase effective control and prevention of this emerging multidrug-resistant fungal pathogen in health care facilities. Copyright © 2018 Leach et al.

  16. System to determine present elements in oily samples

    International Nuclear Information System (INIS)

    Mendoza G, Y.

    2004-11-01

    In the Chemistry Department of the National Institute of Nuclear Investigations of Mexico, dedicated to analyze samples of oleaginous material and of another origin, to determine the elements of the periodic table present in the samples, through the Neutron activation analysis technique (NAA). This technique has been developed to determine majority elements in any solid, aqueous, industrial and environmental sample, which consists basically on to irradiate a sample with neutrons coming from the TRIGA Mark III reactor and to carry out the analysis to obtain those gamma spectra that it emits, for finally to process the information, the quantification of the analysis it is carried out in a manual way, which requires to carry out a great quantity of calculations. The main objective of this project is the development of a software that allows to carry out the quantitative analysis of the NAA for the multielemental determination of samples in an automatic way. To fulfill the objective of this project it has been divided in four chapters: In the first chapter it is shortly presented the history on radioactivity and basic concepts that will allow us penetrate better to this work. In the second chapter the NAA is explained which is used in the sample analysis, the description of the process to be carried out, its are mentioned the characteristics of the used devices and an example of the process is illustrated. In the third chapter it is described the development of the algorithm and the selection of the programming language. The fourth chapter it is shown the structure of the system, the general form of operation, the execution of processes and the obtention of results. Later on the launched results are presented in the development of the present project. (Author)

  17. Validation of a numerical release model (REPCOM) for the Finnish reactor waste disposal systems: Pt.1

    International Nuclear Information System (INIS)

    Nykyri, Mikko

    1987-05-01

    The aim of the work is to model experimentally the inner structures and materials of two reactor waste repositories and to use the results for the validation work of a numerical near field release model, REPCOM. The experimental modelling of the multibarrier systems is conducted on a laboratory scale by using the same principal materials as are employed in the Finnish reactor waste disposal concepts. The migration of radionuclides is studied in two or more consecutive material layers. The laboratory arrangements include the following test materials: bituminized resin, cemented resin, concrete, crushed rock, and water. The materials correspond to the local materials in the planned disposal systems. Cs-137, Co-60, Sr-85, and Sr-90 are used as tracers, with which the resin, water, and crushed rock are labeled depending on the specimen type. The basic specimen geometries are cylindrical and cubic. In the cylindrical geometry the test materials were placed into PVC-tubes. The corresponding numerical model is one-dimensional. In the cubic geometry the materials were placed inside each other. The boundaries form cubes, and the numerical model is three-dimensional. Altogether 12 test system types were produced. The gamma active nuclides in the cylindrical samples were measured nondestructively with a scanner in order to determine the activity profiles in the specimens. The gamma active nuclides in the cubic samples and the beta emeitting Sr-90 in separate samples will be measured after splitting the samples. One to five activity profiles were determined for each cylindrical gamma-active sample. There are already clear diffusion profiles to be had for strontium in crushed rock, and for cesium in crushed rock and in concrete. Cobalt indicated no diffusion. No activity profiles were measured for the cubic samples or for the beta active, Sr-90-doped samples

  18. Development and Validation of Sterility Systems for Trees

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Steve; Shevchenko, Olga; Ma, Caiping (Cathleen)

    2007-03-30

    The overall goal of this project was to develop and validate sterility systems in poplar with the ultimate goal of fulfilling the basic requirements for commercial use. For this, sterility must be complete and stable over multiple growing seasons, cause no detrimental effects on vegetative growth, and successful transformation events must be identifiable via molecular tests when trees are still juvenile. Because of the inherent difficulties in achieving and demonstrating complete sterility in trees, our approach was to study alternate sterility systems in Arabidopsis and/or early-flowering tree systems. The public benefit from this work is the capacity for containment of genes or exotic forms of trees so they can be of benefit for industry for production of wood, energy, and renewable products, while having minimal impact on wild populations of trees. We tested three methods for engineering sterility: dominant negative mutant (DNM) proteins, floral tissue ablation, and RNA interference (RNAi) to suppress the expression of several floral regulatory genes. The ultimate goal of this work was to produce a number of transgenic poplars that could be outplanted to enable future assessments of the effectiveness of these transgenic sterility methods. Our attempts to produce ablation constructs that did not interfere with tree health were partially successful. Using the poplar LEAFY gene promoter and the barnase/barstar system, we were able to regenerate plants that grew well in the greenhouse, but they showed poor health in the field. Four of seven DNM genes tested were considered promising enough, based on results in Arabidopsis, to produce transgenic poplars. Single, double, and triple RNAi genes were produced and transformed into poplar. Over all, we produced 1,964 PCR-confirmed transgenic events with 19 different kinds of sterility genes and several kinds of control genes. We propagated 5,640, 6,820, and 7,055 trees for each of three test poplar genotypes, and field

  19. A tracking system for groundwater sampling and data transfer schedules

    International Nuclear Information System (INIS)

    Mercier, T.M.

    1990-12-01

    Since groundwater monitoring programs at the Oak Ridge Y-12 Plant have become more complex and varied and as the occasions to respond to internal and external reporting requirements have become more frequent and time constrained, the need to track groundwater sampling activities and data transfer from the analytical laboratories has become imperative. If backlogs can be caught early, resources can be added or reallocated in the field and in the laboratory in a timely manner to ensure reporting deadlines are met. The tracking system discussed in this paper starts with clear definition of the groundwater monitoring program at the facility. This information is input into base datasets at the beginning of the sampling cycle. As the sampling program progresses, information about well sampling dates and data transfer dates is input into the base datasets. From the base program data and the update data, a status report is periodically generated by a computer program which identifies the type and nature of bottle necks encountered during the implementation of the groundwater monitoring program

  20. Evaluating the Validity of a Two-stage Sample in a Birth Cohort Established from Administrative Databases.

    Science.gov (United States)

    El-Zein, Mariam; Conus, Florence; Benedetti, Andrea; Parent, Marie-Elise; Rousseau, Marie-Claude

    2016-01-01

    When using administrative databases for epidemiologic research, a subsample of subjects can be interviewed, eliciting information on undocumented confounders. This article presents a thorough investigation of the validity of a two-stage sample encompassing an assessment of nonparticipation and quantification of the extent of bias. Established through record linkage of administrative databases, the Québec Birth Cohort on Immunity and Health (n = 81,496) aims to study the association between Bacillus Calmette-Guérin vaccination and asthma. Among 76,623 subjects classified in four Bacillus Calmette-Guérin-asthma strata, a two-stage sampling strategy with a balanced design was used to randomly select individuals for interviews. We compared stratum-specific sociodemographic characteristics and healthcare utilization of stage 2 participants (n = 1,643) with those of eligible nonparticipants (n = 74,980) and nonrespondents (n = 3,157). We used logistic regression to determine whether participation varied across strata according to these characteristics. The effect of nonparticipation was described by the relative odds ratio (ROR = ORparticipants/ORsource population) for the association between sociodemographic characteristics and asthma. Parental age at childbirth, area of residence, family income, and healthcare utilization were comparable between groups. Participants were slightly more likely to be women and have a mother born in Québec. Participation did not vary across strata by sex, parental birthplace, or material and social deprivation. Estimates were not biased by nonparticipation; most RORs were below one and bias never exceeded 20%. Our analyses evaluate and provide a detailed demonstration of the validity of a two-stage sample for researchers assembling similar research infrastructures.