40 CFR 300.300 - Phase I-Discovery or notification.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Phase I-Discovery or notification. 300.300 Section 300.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND... person in charge of a vessel or a facility shall, as soon as he or she has knowledge of any discharge...

Design of a self-aligned, wide temperature range (300 mK-300 K) atomic force microscope/magnetic force microscope with 10 nm magnetic force microscope resolution

Energy Technology Data Exchange (ETDEWEB)

Karcı, Özgür [NanoMagnetics Instruments Ltd., Hacettepe - İvedik OSB Teknokent, 1368. Cad., No: 61/33, 06370, Yenimahalle, Ankara (Turkey); Department of Nanotechnology and Nanomedicine, Hacettepe University, Beytepe, 06800 Ankara (Turkey); Dede, Münir [NanoMagnetics Instruments Ltd., Hacettepe - İvedik OSB Teknokent, 1368. Cad., No: 61/33, 06370, Yenimahalle, Ankara (Turkey); Oral, Ahmet, E-mail: orahmet@metu.edu.tr [Department of Physics, Middle East Technical University, 06800 Ankara (Turkey)

2014-10-01

We describe the design of a wide temperature range (300 mK-300 K) atomic force microscope/magnetic force microscope with a self-aligned fibre-cantilever mechanism. An alignment chip with alignment groves and a special mechanical design are used to eliminate tedious and time consuming fibre-cantilever alignment procedure for the entire temperature range. A low noise, Michelson fibre interferometer was integrated into the system for measuring deflection of the cantilever. The spectral noise density of the system was measured to be ~12 fm/√Hz at 4.2 K at 3 mW incident optical power. Abrikosov vortices in BSCCO(2212) single crystal sample and a high density hard disk sample were imaged at 10 nm resolution to demonstrate the performance of the system.

Design of a self-aligned, wide temperature range (300 mK-300 K) atomic force microscope/magnetic force microscope with 10 nm magnetic force microscope resolution

International Nuclear Information System (INIS)

Karcı, Özgür; Dede, Münir; Oral, Ahmet

2014-01-01

We describe the design of a wide temperature range (300 mK-300 K) atomic force microscope/magnetic force microscope with a self-aligned fibre-cantilever mechanism. An alignment chip with alignment groves and a special mechanical design are used to eliminate tedious and time consuming fibre-cantilever alignment procedure for the entire temperature range. A low noise, Michelson fibre interferometer was integrated into the system for measuring deflection of the cantilever. The spectral noise density of the system was measured to be ∼12 fm/√Hz at 4.2 K at 3 mW incident optical power. Abrikosov vortices in BSCCO(2212) single crystal sample and a high density hard disk sample were imaged at 10 nm resolution to demonstrate the performance of the system

A survey for elevated levels of uranium north of the 300 Area on the Hanford Site

International Nuclear Information System (INIS)

Poston, T.M.

1990-04-01

A comprehensive survey of soil uranium (U) concentrations in a study area due north of the 300 Area on the Hanford site has been conducted by Pacific Northwest Laboratory (PNL). The objective of the study was to determine the spatial distribution of uranium in the study area and to ascertain if background levels of uranium have been increased by Hanford operations. Based on the spatial distribution of 238 U, the highest concentrations of uranium are located in the southern portion of the study area adjacent to the 300 Area complex and in the most eastern zone of the study site bordering the Columbia River. Uranium-236, an isotopic marker of fuel processing activities in the 300 Area, was detected in all eight samples selected from the study. A significant and positive regression was demonstrated between the ratios of 236 U/ 238 U in these eight samples and proximity to the 300 Area. 9 refs., 18 figs., 9 tabs

AMS measurement of samples smaller than 300 {mu}g at center for applied isotope studies, University of Georgia

Energy Technology Data Exchange (ETDEWEB)

Cherkinsky, Alexander, E-mail: acherkin@uga.edu [CENTER FOR APPLIED ISOTOPE STUDIES, University of Georgia, 120 Riverbend Road, Athens, GA 30602 (United States); Ravi Prasad, G.V.; Dvoracek, Doug [CENTER FOR APPLIED ISOTOPE STUDIES, University of Georgia, 120 Riverbend Road, Athens, GA 30602 (United States)

2013-01-15

The center for applied isotope studies has developed a protocol for the measurement of radiocarbon in the range 0.01-0.3 mg of carbon. We analyzed a series of radiocarbon-free and modern standards using the same sample preparation procedure as for unknown samples. We have studied the size dependency of {sup 12}C and {sup 13}C beam currents and {sup 14}C/{sup 13}C ratios from cathodes containing less than 1 mg of carbon. The iron catalyst used for graphite preparation contains some carbon with activity about 60 pMC and the level of contamination varies between batches from the same supplier. The cathodes in the range smaller than 50 {mu}g showed a very significant dependency between current and the sample size. In this range the current increased by about fifteen-fold; between 50 and 100 {mu}g the current increased two-fold. Samples larger than 300 {mu}g have shown negligible current variation. The {sup 14}C/{sup 13}C ratio was significantly affected only for the samples less than 50 {mu}g. Larger samples have shown very little variation in the {sup 14}C/{sup 13}C ratio. For the measurement of ultra-small unknown samples in the range of 10-50 {mu}g, we have found it to be important to use blanks and modern standards with exactly the same amount of carbon, which makes it possible to apply a mass-balanced correction.

76 FR 56489 - Request for a License To Export Radioactive Waste

Science.gov (United States)

2011-09-13

... NUCLEAR REGULATORY COMMISSION Request for a License To Export Radioactive Waste Pursuant to 10 CFR... quantity End use country Duratek Services, Inc., August Class A radioactive Radionuclide Non-conforming Canada. 17, 2011, August 18, 2011, waste in the form reallocation: materials XW010/02, 11005620. of...

Individual differences in P300 amplitude: a genetic study in adolescent twins

NARCIS (Netherlands)

van Beijsterveldt, C.E.M.; Molenaar, P.C.M.; de Geus, E.J.C.; Boomsma, D.I.

1998-01-01

Using quantitative genetic research designs, we decomposed phenotypic variance in P300 parameters into genetic and environmental components. The twin method was used to carry out this decomposition. Event related potentials (ERPs) were measured during a visual oddball paradigm in a sample of 213

Individual differences in P300 amplitude: A genetic study in adolescent twins.

NARCIS (Netherlands)

van Beijsterveld, C.E.M.; Molenaar, P.C.M.; de Geus, E.J.C.; Boomsma, D.I.

1998-01-01

Using quantitative genetic research designs, we decomposed phenotypic variance in P300 parameters into genetic and environmental components. The twin method was used to carry out this decomposition. Event related potentials (ERPs) were measured during a visual oddball paradigm in a sample of 213

Effects of ZNF804A on auditory P300 response in schizophrenia.

LENUS (Irish Health Repository)

O'Donoghue, T

2014-01-01

The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies. Although associated with a pattern of altered neural connectivity, evidence that increased risk is mediated by an effect on cognitive deficits associated with the disorder has been equivocal. This study investigated whether the same ZNF804A risk allele was associated with variation in the P300 auditory-evoked response, a cognitively relevant putative endophenotype for SZ. We compared P300 responses in carriers and noncarriers of the ZNF804A risk allele genotype groups in Irish patients and controls (n=97). P300 response was observed to vary according to genotype in this sample, such that risk allele carriers showed relatively higher P300 response compared with noncarriers. This finding accords with behavioural data reported by our group and others. It is also consistent with the idea that ZNF804A may have an impact on cortical efficiency, reflected in the higher levels of activations required to achieve comparable behavioural accuracy on the task used.

Intercomparison of radionuclide measurements on marine sediment sample IAEA-300

International Nuclear Information System (INIS)

Ballestra, S.; Gastaud, J.; Lopez, J.J.; Parsi, P.; Vas, D.

1994-09-01

The results of an intercomparison exercise on a sediment from Baltic Sea, IAEA-300, designed for the determination of artificial and natural radionuclides' levels, are reported. The data from 159 laboratories representing 51 countries have been evaluated. The following are the recommended values, with confidence intervals, 40 K, 60 Co, 125 Sb, 134 Cs, 137 Cs, 155 Eu, 210 Pb, 210 Po, 228 Ra, 234 U, 238 U, 239+240 Pu and 241 Am. Information values for 54 Mn, 90 Sr, 226 Ra, 228 Th, 230 Th, 232 Th, 235 U and 238 Pu are also reported. All values are given on the reference date of 1 January 1993 and expressed in Bq kg -1 dry weight. (author)

300 Area TEDF NPDES Permit Compliance Monitoring Plan

International Nuclear Information System (INIS)

Loll, C.M.

1994-01-01

This monitoring plan describes the activities and methods that will be employed at the 300 Area Treated Effluent Disposal Facility (TEDF) in order to ensure compliance with the National Discharge Elimination System (NPDES) permit. Included in this document are a brief description of the project, the specifics of the sampling effort, including the physical location and frequency of sampling, the support required for sampling, and the Quality Assurance (QA) protocols to be followed in the sampling procedures

40 CFR 300.440 - Procedures for planning and implementing off-site response actions.

Science.gov (United States)

2010-07-01

... unless the Remedial Project Manager or OSC assures the proper management of the CERCLA waste samples or... OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Hazardous Substance Response § 300.440... § 300.440(d). (5) Off-site transfers of those laboratory samples and treatability study CERCLA wastes...

City of Richland 300 Area industrial wastewater permit application

International Nuclear Information System (INIS)

1995-05-01

Battelle-Pacific Northwest Labs and Westinghouse Hanford Co. are responsible for operating most of the facilities within the 300 Area; other contractors are also involved. The document gives briefly water/wastewater data: water sources, water usage, water discharge/loss, NPDES permit status, plant sewer outlets size and flow, etc. The document also includes the following attachments: 300 Area building list, Oct. 1993-Oct. 1994 300 Area water balance, waste shipments for CY 1994, complete chemical listing, sanitary sewer sampling results (12/19/94, 1/18/95, 1/15/95), and priority pollutant listings

Trace analysis for 300 MM wafers and processes with TXRF

International Nuclear Information System (INIS)

Nutsch, A.; Erdmann, V.; Zielonka, G.; Pfitzner, L.; Ryssel, H.

2000-01-01

Efficient fabrication of semiconductor devices is combined with an increasing size of silicon wafers. The contamination level of processes, media, and equipment has to decrease continuously. A new test laboratory for 300 mm was installed in view of the above mentioned aspects. Aside of numerous processing tools this platform consist electrical test methods, particle detection, vapor phase decomposition (VPD) preparation, and TXRF. The equipment is installed in a cleanroom. It is common to perform process or equipment control, development, evaluation and qualification with monitor wafers. The evaluation and the qualification of 300 mm equipment require direct TXRF on 300 mm wafers. A new TXRF setup was installed due to the wafer size of 300 mm. The 300 mm TXRF is equipped with tungsten and molybdenum anode. This combination allows a sensitive detection of elements with fluorescence energy below 10 keV for tungsten excitation. The molybdenum excitation enables the detection of a wide variety of elements. The detection sensitivity for the tungsten anode excited samples is ten times higher than for molybdenum anode measured samples. The system is calibrated with 1 ng Ni. This calibration shows a stability within 5 % when monitored to control system stability. Decreasing the amount of Ni linear results in a linear decrease of the measured Ni signal. This result is verified for a range of elements by multielement samples. New designs demand new processes and materials, e.g. ferroelectric layers and copper. The trace analysis of many of these materials is supported by the higher excitation energy of the molybdenum anode. Reclaim and recycling of 300 mm wafers demand for an accurate contamination control of the processes to avoid cross contamination. Polishing or etching result in modified surfaces. TXRF as a non-destructive test method allows the simultaneously detection of a variety of elements on differing surfaces in view of contamination control and process

Identification of phosphatidylserine as a ligand for the CD300a immunoreceptor

Energy Technology Data Exchange (ETDEWEB)

Nakahashi-Oda, Chigusa; Tahara-Hanaoka, Satoko; Honda, Shin-ichiro [Department of Immunology, Division of Biomedical Sciences, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 (Japan); Japan Science and Technology Agency, CREST, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 (Japan); Shibuya, Kazuko [Department of Immunology, Division of Biomedical Sciences, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 (Japan); Shibuya, Akira, E-mail: ashibuya@md.tsukuba.ac.jp [Department of Immunology, Division of Biomedical Sciences, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 (Japan); Japan Science and Technology Agency, CREST, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 (Japan)

2012-01-06

Highlights: Black-Right-Pointing-Pointer CD300a is a new phosphatidylserine receptor expressed on myeloid cells. Black-Right-Pointing-Pointer Phosphatidylserine delivers a signal for recruitment of SHP-1 by CD300a in mast cells. Black-Right-Pointing-Pointer The CD300a/phosphatidylserine interaction is blocked by MFG-E8 or anti-CD300a antibody. -- Abstract: CD300a is a member of CD300 family molecules consisting of seven genes on human chromosome 17 and nine genes in mouse chromosome 11. CD300a has a long cytoplasmic region containing the consensus immunoreceptor tyrosine-based inhibitory motif (ITIM) sequence. Upon crosslinking with antibodies against CD300a, CD300a mediates an inhibitory signal in myeloid cells. However, the ligand for CD300a has not been identified and the physiological role of CD300a remained unclear. Here, we demonstrate that the chimeric fusion protein of CD300a extracellular domain with the Fc portion of human IgG specifically bound phosphatidylserine (PS), which is exposed on the outer leaflet of the plasma membrane of apoptotic cells. PS binding to CD300a induced SHP-1 recruitment by CD300a in mast cells in response to LPS. These results indicated that CD300a is a new PS receptor.

300-FF-1 remedial design report/remedial action work plan

Energy Technology Data Exchange (ETDEWEB)

Gustafson, F.W.

1997-02-01

The 300 Area has been divided into three operable units 300-FF-1, 300-FF-2, and 300-FF-5 all of which are in various stages of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) process. The 300-FF-1 Operable Unit, the subject of this report, includes liquid waste disposal sites, landfills, and a burial ground. This Remedial Design Report/Remedial Action Work Plan (RDR/RAWP) provides a summary description of each waste site included in the 300-FF-1 Operable Unit, the basis for remedial actions to be taken, and the remedial action approach and management process for implementing these actions. The remedial action approach and management sections provide a description of the remedial action process description, the project schedule, the project team, required planning documentation, the remedial action change process, the process for verifying attainment of the remedial action goals, and the required CERCLA and RCRA closeout documentation. Appendix A provides additional details on each waste site. In addition to remediation of the waste sites, waste generated during the remedial investigation/feasibility study portions of the project will also be disposed at the Environmental Restoration Disposal Facility (ERDF). Appendix B provides a summary of the modeling performed in the 300-FF-1 Phase 3 FS and a description of the modeling effort to be used to show attainment of the remedial action goals. Appendix C provides the sampling and analysis plan (SAP) for all sampling and field-screening activities performed during remediation and for verification of attainment with the remedial action goals. Appendix D provides the public involvement plan, prepared to ensure information is provided to the public during remedial design and remedial action processes.

300-FF-1 remedial design report/remedial action work plan

International Nuclear Information System (INIS)

Gustafson, F.W.

1997-02-01

The 300 Area has been divided into three operable units 300-FF-1, 300-FF-2, and 300-FF-5 all of which are in various stages of the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) process. The 300-FF-1 Operable Unit, the subject of this report, includes liquid waste disposal sites, landfills, and a burial ground. This Remedial Design Report/Remedial Action Work Plan (RDR/RAWP) provides a summary description of each waste site included in the 300-FF-1 Operable Unit, the basis for remedial actions to be taken, and the remedial action approach and management process for implementing these actions. The remedial action approach and management sections provide a description of the remedial action process description, the project schedule, the project team, required planning documentation, the remedial action change process, the process for verifying attainment of the remedial action goals, and the required CERCLA and RCRA closeout documentation. Appendix A provides additional details on each waste site. In addition to remediation of the waste sites, waste generated during the remedial investigation/feasibility study portions of the project will also be disposed at the Environmental Restoration Disposal Facility (ERDF). Appendix B provides a summary of the modeling performed in the 300-FF-1 Phase 3 FS and a description of the modeling effort to be used to show attainment of the remedial action goals. Appendix C provides the sampling and analysis plan (SAP) for all sampling and field-screening activities performed during remediation and for verification of attainment with the remedial action goals. Appendix D provides the public involvement plan, prepared to ensure information is provided to the public during remedial design and remedial action processes

34 CFR 300.8 - Child with a disability.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Child with a disability. 300.8 Section 300.8 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH... education, the child is not a child with a disability under this part. (ii) If, consistent with § 300.39(a...

Intercomparison of radionuclide measurements on marine sediment sample IAEA-300

Energy Technology Data Exchange (ETDEWEB)

Ballestra, S; Gastaud, J; Lopez, J J; Parsi, P; Vas, D

1994-09-01

The results of an intercomparison exercise on a sediment from Baltic Sea, IAEA-300, designed for the determination of artificial and natural radionuclides' levels, are reported. The data from 159 laboratories representing 51 countries have been evaluated. The following are the recommended values, with confidence intervals, {sup 40}K, {sup 60}Co, {sup 125}Sb, {sup 134}Cs, {sup 137}Cs, {sup 155}Eu, {sup 210}Pb, {sup 210}Po, {sup 228}Ra, {sup 234}U, {sup 238}U, {sup 239+240}Pu and {sup 241}Am. Information values for {sup 54}Mn, {sup 90}Sr, {sup 226}Ra, {sup 228}Th, {sup 230}Th, {sup 232}Th, {sup 235}U and {sup 238}Pu are also reported. All values are given on the reference date of 1 January 1993 and expressed in Bq kg{sup -1} dry weight. (author)

Modular Multi-Sensor Display System Design Study. Volume 1. Requirements Analysis and Design Studies

Science.gov (United States)

1974-08-01

1 0.00001 0.00001 0.00003 Residual 1x2x3 1 0.01002 0.01002 0.0348 Total 11 0.28822 Gray Shade Quantization. The main effect of gray shade...Quantization 3 Tararets 1 x 2 1 x 3 Z x i 1x2x3 RppTiratjnns Totals Degrees Freedom 1 2 5 10 10 3j6 71 Sum Squares 0.6463 0.5985 1.2009...x 3 2x3 1x2x3 Replications Totals DF 1 2 5 2 5 10 10 36 71 5S 1708.8 1413.2 2355.5 39.6 1342.2 1563.9 1568.8 2583.8 12576.1

Molecular cloud-scale star formation in NGC 300

Energy Technology Data Exchange (ETDEWEB)

Faesi, Christopher M.; Lada, Charles J.; Forbrich, Jan [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Menten, Karl M. [Max Planck Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Bouy, Hervé [Centro de Astrobiología, (INTA-CSIC), Departamento de Astrofísica, POB 78, ESAC Campus, 28691 Villanueva dela Cañada (Spain)

2014-07-01

We present the results of a galaxy-wide study of molecular gas and star formation in a sample of 76 H II regions in the nearby spiral galaxy NGC 300. We have measured the molecular gas at 250 pc scales using pointed CO(J = 2-1) observations with the Atacama Pathfinder Experiment telescope. We detect CO in 42 of our targets, deriving molecular gas masses ranging from our sensitivity limit of ∼10{sup 5} M {sub ☉} to 7 × 10{sup 5} M {sub ☉}. We find a clear decline in the CO detection rate with galactocentric distance, which we attribute primarily to the decreasing radial metallicity gradient in NGC 300. We combine Galaxy Evolution Explorer far-ultraviolet, Spitzer 24 μm, and Hα narrowband imaging to measure the star formation activity in our sample. We have developed a new direct modeling approach for computing star formation rates (SFRs) that utilizes these data and population synthesis models to derive the masses and ages of the young stellar clusters associated with each of our H II region targets. We find a characteristic gas depletion time of 230 Myr at 250 pc scales in NGC 300, more similar to the results obtained for Milky Way giant molecular clouds than the longer (>2 Gyr) global depletion times derived for entire galaxies and kiloparsec-sized regions within them. This difference is partially due to the fact that our study accounts for only the gas and stars within the youngest star-forming regions. We also note a large scatter in the NGC 300 SFR-molecular gas mass scaling relation that is furthermore consistent with the Milky Way cloud results. This scatter likely represents real differences in giant molecular cloud physical properties such as the dense gas fraction.

UOP LDR 300 All Assignments New

OpenAIRE

ADMIN

2018-01-01

UOP LDR 300 All Assignments New Check this A+ tutorial guideline at http://www.ldr300assignment.com/ldr-300-uop/ldr-300-all-assignments-latest For more classes visit http://www.ldr300assignment.com LDR 300 Week 1 Assignment Leadership Assessment (2 Papers) LDR 300 Week 2 Assignment Leadership Theories Matrix (2 Set) LDR 300 Week 2 Assignment Formulating Leadership Part I (2 Papers) LDR 300 Week 3 Assignment Interaction and Influence Amo...

Dgroup: DG01002 [KEGG MEDICUS

Lifescience Database Archive (English)

Full Text Available gonist ... DG01563 ... mu-Opioid receptor agonist Analgesic ... DG01984 ... Opioid analgesics Other ... DG01718 ... Drugs for... addictive disorder ... DG01717 ... Drugs for opioid dependence Cyp substrate ... DG01633

Beneficial uses program. Progress report, period ending 31 December 1975

International Nuclear Information System (INIS)

1976-02-01

Progress is reported on studies designed to develop the necessary technologies for cost-beneficial uses of existing and future surplus radioactive materials. The purpose of the Waste Resources Utilization Program is to develop a technology to utilize cesium-137, a nuclear power plant by-product, to modify sewage sludge for safe application as a fertilizer or as an animal feed supplement. A major portion of the effort this quarter was directed toward establishment of thermoradiation treatment levels for elimination of pathogenic organisms in sludge. Three groups of pathogenic microorganisms are being studied: viruses, bacteria, and parasites. Other areas of study included physical-chemical properties of thermoradiation treated sewage sludge such as ''settling'' and ''filterability'' and pilot plant design for a plant to thermoradiate up to 75 kiloliters of sludge per day. In the Separation Technology and Source Development Program previous work has demonstrated the feasibility of applying the Sandia Solidification Process to the recovery of radiocesium from high-level liquid wastes. The influence of various parameters on 137 Cs source intensities was explored. A multiple ceramic 137 Cs source package was found to be essentially the same from a radiation process viewpoint as a single 137 Cs source. The tolerable impurity levels in the ceramic sources, in terms of perturbation of the gamma flux, are relatively high (a few percent)

Soil washing physical separations test procedure - 300-FF-1 operable unit

Energy Technology Data Exchange (ETDEWEB)

Belden, R.D.

1993-10-08

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The {open_quotes}Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,{close_quotes} Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the {open_quotes}300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,{close_quotes} (DOE-RL 1993).

Soil washing physical separations test procedure - 300-FF-1 operable unit

International Nuclear Information System (INIS)

Belden, R.D.

1993-01-01

This procedure provides the operations approach, a field sampling plan, and laboratory procedures for a soil washing test to be conducted by Alternative Remedial Technologies, Inc. (ART) in the 300-FF-1 area at the Hanford site. The open-quotes Quality Assurance Project Plan for the Soil Washing Physical Separations Test, 300-FF-1 Operable Unit,close quotes Hanford, Washington, Alternative Remedial Technologies, Inc., February 1994 (QAPP) is provided in a separate document that presents the procedural and organizational guidelines for this test. This document describes specifications, responsibilities, and general procedures to be followed to conduct physical separation soil treatability tests in the North Process Pond of the 300-FF-1 Operable Unit (OU) at the Hanford Site. These procedures are based on the open-quotes 300-FF-1 Physical Separations CERCLA Treatability Test Plan, DOE/RL 92-2l,close quotes (DOE-RL 1993)

Economical evaluation on gas turbine high temperature reactor 300 (GTHTR300)

International Nuclear Information System (INIS)

Takei, Masanobu; Kosugiyama, Shinichi; Mouri, Tomoaki; Katanishi, Shoji; Kunitomi, Kazuhiko

2006-01-01

Japan Atomic Energy Research Institute (JAERI) has been developing a graphite moderate and helium cooled High Temperature Gas-cooled Reactor (HTGR) with gas turbine, the GTHTR300 based on experience gained in development and operations of the High Temperature Engineering Test Reactor (HTTR) in JAERI. The GTHTR300 is a simplified and economical power plant with a high level of safety characteristics and a high plant efficiency of approximately 46%. Cost evaluation for plant construction and power generation is studied in order to clarify the economical feasibility of the GTHTR300. The construction cost is estimated to be about 200 thousands Yen/kWe. The power generation cost is estimated to be about 3.8 Yen/kWh by the conditions of 90% load factor and 3% discount rate. The economical feasibility of the GTHTR300 is certified. The present study is entrusted from Ministry of Education, Culture, Sports, Science and Technology of Japan. (author)

34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

Science.gov (United States)

2010-07-01

... assessments 300.320(a)(6)(i). • State level activities in support of 300.704(b)(4)(x). ACT (Definition) 300.4... definition of “Secondary school” 300.36. • State-level activities regarding charter schools 300.704(b)(4)(ix... determination • Lack of instruction in reading or math (see § 300.306(b)(1)(i), (b)(1)(ii)) • Limited English...

34 CFR 300.506 - Mediation.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Mediation. 300.506 Section 300.506 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.506 Mediation. (a... due process complaint, to resolve disputes through a mediation process. (b) Requirements. The...

A covert attention P300-based brain-computer interface: Geospell.

Science.gov (United States)

Aloise, Fabio; Aricò, Pietro; Schettini, Francesca; Riccio, Angela; Salinari, Serenella; Mattia, Donatella; Babiloni, Fabio; Cincotti, Febo

2012-01-01

The Farwell and Donchin P300 speller interface is one of the most widely used brain-computer interface (BCI) paradigms for writing text. Recent studies have shown that the recognition accuracy of the P300 speller decreases significantly when eye movement is impaired. This report introduces the GeoSpell interface (Geometric Speller), which implements a stimulation framework for a P300-based BCI that has been optimised for operation in covert visual attention. We compared the Geospell with the P300 speller interface under overt attention conditions with regard to effectiveness, efficiency and user satisfaction. Ten healthy subjects participated in the study. The performance of the GeoSpell interface in covert attention was comparable with that of the P300 speller in overt attention. As expected, the effectiveness of the spelling decreased with the new interface in covert attention. The NASA task load index (TLX) for workload assessment did not differ significantly between the two modalities. This study introduces and evaluates a gaze-independent, P300-based brain-computer interface, the efficacy and user satisfaction of which were comparable with those off the classical P300 speller. Despite a decrease in effectiveness due to the use of covert attention, the performance of the GeoSpell far exceeded the threshold of accuracy with regard to effective spelling.

9 CFR 381.300 - Definitions.

Science.gov (United States)

2010-01-01

... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Canning and Canned Products § 381.300 Definitions. (a... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Definitions. 381.300 Section 381.300 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY...

A new hybrid BCI paradigm based on P300 and SSVEP.

Science.gov (United States)

Wang, Minjue; Daly, Ian; Allison, Brendan Z; Jin, Jing; Zhang, Yu; Chen, Lanlan; Wang, Xingyu

2015-04-15

P300 and steady-state visual evoked potential (SSVEP) approaches have been widely used for brain-computer interface (BCI) systems. However, neither of these approaches can work for all subjects. Some groups have reported that a hybrid BCI that combines two or more approaches might provide BCI functionality to more users. Hybrid P300/SSVEP BCIs have only recently been developed and validated, and very few avenues to improve performance have been explored. The present study compares an established hybrid P300/SSVEP BCIs paradigm to a new paradigm in which shape changing, instead of color changing, is adopted for P300 evocation to decrease the degradation on SSVEP strength. The result shows that the new hybrid paradigm presented in this paper yields much better performance than the normal hybrid paradigm. A performance increase of nearly 20% in SSVEP classification is achieved using the new hybrid paradigm in comparison with the normal hybrid paradigm. All the paradigms except the normal hybrid paradigm used in this paper obtain 100% accuracy in P300 classification. The new hybrid P300/SSVEP BCIs paradigm in which shape changing, instead of color changing, could obtain as high classification accuracy of SSVEP as the traditional SSVEP paradigm and could obtain as high classification accuracy of P300 as the traditional P300 paradigm. P300 did not interfere with the SSVEP response using the new hybrid paradigm presented in this paper, which was superior to the normal hybrid P300/SSVEP paradigm. Copyright © 2014 Elsevier B.V. All rights reserved.

Strength and microstructure in vadium irradiated with T(d,n) neutrons at 300 to 675K

International Nuclear Information System (INIS)

Bradley, E.R.

1984-12-01

Tensile tests and microstructural examination have been conducted on vanadium wires and foils following T(d,n) neutron irradiation at 300K, 475K, and 675K. Similar increases in yield strength were measured for samples irradiated at 300K and 475K but less strengthening occurred during irradiation at 675K. Examination of the fracture surfaces showed that all samples failed by ductile rupture after attaining more than 95% reduction in area. A reasonable correlation between microstructures and strengthing was obtained using a simple dispersed barrier strengthening model. A high density of small defect clusters was responsible for strengthening after irradiation at 300K. Following irradiation at 475K, interstitial loops with a Burgers vectors were the predominant strengthening defect with a smaller contribution from a/2 type loops. A heterogeneous distribution of dislocation loops and planar precipitates prevented definite correlations between strength and microstructure in samples irradiated at 675K

40 CFR 63.300 - Applicability.

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2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Applicability. 63.300 Section 63.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... Oven Batteries § 63.300 Applicability. (a) Unless otherwise specified in §§ 63.306, 63.307, and 63.311...

34 CFR 300.516 - Civil action.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Civil action. 300.516 Section 300.516 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.516 Civil action. (a... aggrieved by the findings and decision under § 300.514(b), has the right to bring a civil action with...

5 CFR 300.301 - Authority.

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2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Authority. 300.301 Section 300.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Details of Employees § 300.301 Authority. (a) In accordance with 5 U.S.C. 3341, an agency may detail an employee in the...

300 Area Process Trenches Verification Package

International Nuclear Information System (INIS)

Lerch, J.A.

1998-03-01

The purpose of this verification package is to document achievement of the remedial action objectives for the 300 Area Process Trenches (300 APT) located within the 300-FF-1 Operable Unit (OU). The 300 APT became active in 1975 as a replacement for the North and South Process Pond system that is also part of the 300-FF-1 OU. The trenches received 300 Area process effluent from the uranium fuel fabrication facilities. Waste from the 300 Area laboratories that was determined to be below discharge limits based on monitoring performed at the 307 retention basin was also released to the trenches. Effluent flowed through the headworks sluice gates, down a concrete apron, and into the trenches. From the beginning of operations in 1975 until 1993, a continuous, composite sampler was located at the headwork structure to analyze process effluent at the point of discharge to the environment

Cost and effectiveness comparisons of various types of sludge irradiation and sludge pasteurization treatments

International Nuclear Information System (INIS)

Morris, M.E.

1976-01-01

The radiation from 137 Cs, a major constituent of nuclear fuel reprocessing waste, can be used to sterilize sewage sludge. This paper compares the effectiveness and cost of heat pasteurization, irradiation, and thermoradiation (simultaneous heating/irradiation), three competing methods of sludge disinfection. The cost of irradiation and thermoradiation is slightly higher than heat pasteurization costs for liquid sludges, although minor changes in oil availability or prices could change this. If the viral destruction could be done easily by other means, a 500-kilorad irradiation dose would be effective and less costly. For dry sewage sludges, irradiation is as effective and much less costly than any of the liquid sludge disinfection processes. Irradiation of compost appears to be cheaper and more practical than any heat pasteurization process for the dry sludge (the insulating property of the compost makes heating difficult). 6 tables, 2 fig

Neuronal correlates of a virtual-reality-based passive sensory P300 network.

Science.gov (United States)

Chen, Chun-Chuan; Syue, Kai-Syun; Li, Kai-Chiun; Yeh, Shih-Ching

2014-01-01

P300, a positive event-related potential (ERP) evoked at around 300 ms after stimulus, can be elicited using an active or passive oddball paradigm. Active P300 requires a person's intentional response, whereas passive P300 does not require an intentional response. Passive P300 has been used in incommunicative patients for consciousness detection and brain computer interface. Active and passive P300 differ in amplitude, but not in latency or scalp distribution. However, no study has addressed the mechanism underlying the production of passive P300. In particular, it remains unclear whether the passive P300 shares an identical active P300 generating network architecture when no response is required. This study aims to explore the hierarchical network of passive sensory P300 production using dynamic causal modelling (DCM) for ERP and a novel virtual reality (VR)-based passive oddball paradigm. Moreover, we investigated the causal relationship of this passive P300 network and the changes in connection strength to address the possible functional roles. A classical ERP analysis was performed to verify that the proposed VR-based game can reliably elicit passive P300. The DCM results suggested that the passive and active P300 share the same parietal-frontal neural network for attentional control and, underlying the passive network, the feed-forward modulation is stronger than the feed-back one. The functional role of this forward modulation may indicate the delivery of sensory information, automatic detection of differences, and stimulus-driven attentional processes involved in performing this passive task. To our best knowledge, this is the first study to address the passive P300 network. The results of this study may provide a reference for future clinical studies on addressing the network alternations under pathological states of incommunicative patients. However, caution is required when comparing patients' analytic results with this study. For example, the task

Neuronal correlates of a virtual-reality-based passive sensory P300 network.

Directory of Open Access Journals (Sweden)

Chun-Chuan Chen

Full Text Available P300, a positive event-related potential (ERP evoked at around 300 ms after stimulus, can be elicited using an active or passive oddball paradigm. Active P300 requires a person's intentional response, whereas passive P300 does not require an intentional response. Passive P300 has been used in incommunicative patients for consciousness detection and brain computer interface. Active and passive P300 differ in amplitude, but not in latency or scalp distribution. However, no study has addressed the mechanism underlying the production of passive P300. In particular, it remains unclear whether the passive P300 shares an identical active P300 generating network architecture when no response is required. This study aims to explore the hierarchical network of passive sensory P300 production using dynamic causal modelling (DCM for ERP and a novel virtual reality (VR-based passive oddball paradigm. Moreover, we investigated the causal relationship of this passive P300 network and the changes in connection strength to address the possible functional roles. A classical ERP analysis was performed to verify that the proposed VR-based game can reliably elicit passive P300. The DCM results suggested that the passive and active P300 share the same parietal-frontal neural network for attentional control and, underlying the passive network, the feed-forward modulation is stronger than the feed-back one. The functional role of this forward modulation may indicate the delivery of sensory information, automatic detection of differences, and stimulus-driven attentional processes involved in performing this passive task. To our best knowledge, this is the first study to address the passive P300 network. The results of this study may provide a reference for future clinical studies on addressing the network alternations under pathological states of incommunicative patients. However, caution is required when comparing patients' analytic results with this study. For example

Caracterização da normalidade do P300 em adultos jovens Standard characterization of P300 in young adults

Directory of Open Access Journals (Sweden)

Cíntia Santos Silva Machado

2009-01-01

Full Text Available OBJETIVO: Comparar com a literatura os valores de latência e amplitude de P300 em adultos jovens brasileiros saudáveis a fim de estabelecer um padrão normativo para futuros estudos, e verificar se os valores encontrados na amostra possuem correlação com o sexo, situação proposta na metodologia do exame e fases do ciclo menstrual. MÉTODOS: A amostra constou de 22 indivíduos saudáveis, sem queixa de desatenção, sem problemas neurológicos e auditivos, de 18 a 30 anos de idade. Todos os indivíduos foram submetidos à avaliação audiológica básica a fim de excluir aqueles com perda de audição. As respostas do P300 foram obtidas com equipamento AMPLAID MK22, de dois canais e em ambiente silencioso. RESULTADOS: Os resultados de latência encontrados na amostra, depois de comparados à literatura, enquadraram-se melhor nos intervalos de latência entre 220 e 380 ms. Somente os valores de amplitude foram influenciados pelas variáveis sexo e fase do ciclo menstrual. CONCLUSÃO: Os valores de latência da amostra não sofreram influência da variável sexo, ciclo menstrual e situação, e aproximaram-se com mais fidedignidade aos valores de intervalos de latência entre 220 e 380 ms. Contudo, os intervalos para a amplitude sofreram influência das variáveis sexo e ciclo menstrual, mas não se enquadraram adequadamente aos valores de intervalo encontrados na literatura.PURPOSE: To compare the values of latency and amplitude of P300 of healthy Brazilian young adults with the data available on the literature, in order to establish a normative standard for future studies. In addition, the aim was also to verify if the values found in the sample were correlated to gender, situation proposed in the methodology of the examination, and phase of menstrual cycle. METHODS: The sample consisted of 22 healthy individuals, without any attention complaints, neurological or auditory disorders, and with ages ranging from 18 to 30 years. All subjects

300 Area Revitalization Project Management Plan

International Nuclear Information System (INIS)

Downey, H. D.

1999-01-01

The 300 Area Revitalization Team has been tasked with the responsibility to develop an integrated path forward for the 300 Area, as part of a commitment stemming from the 300 Area Disposition Workshop that was held on March 17, 1998. The integrated path forward that is needed must ensure that budget, schedule, and work scopes are complementary between the Programs that are involved in the 300Area. This Project Management Plan (PMP) defines the roles and responsibilities, and the overall approach, to development of a prioritized schedule for 300 Area activities that will achieve the end-state condition

P300 development across the lifespan: a systematic review and meta-analysis.

Directory of Open Access Journals (Sweden)

Rik van Dinteren

Full Text Available BACKGROUND: The P300 component of the event-related potential is a large positive waveform that can be extracted from the ongoing electroencephalogram using a two-stimuli oddball paradigm, and has been associated with cognitive information processing (e.g. memory, attention, executive function. This paper reviews the development of the auditory P300 across the lifespan. METHODOLOGY/PRINCIPAL FINDINGS: A systematic review and meta-analysis on the P300 was performed including 75 studies (n = 2,811. Scopus was searched for studies using healthy subjects and that reported means of P300 latency and amplitude measured at Pz and mean age. These findings were validated in an independent, existing cross-sectional dataset including 1,572 participants from ages 6-87. Curve-fitting procedures were applied to obtain a model of P300 development across the lifespan. In both studies logarithmic Gaussian models fitted the latency and amplitude data best. The P300 latency and amplitude follow a maturational path from childhood to adolescence, resulting in a period that marks a plateau, after which degenerative effects begin. We were able to determine ages that mark a maximum (in P300 amplitude or trough (in P300 latency segregating maturational from degenerative stages. We found these points of deflection occurred at different ages. CONCLUSIONS/SIGNIFICANCE: It is hypothesized that latency and amplitude index different aspects of brain maturation. The P300 latency possibly indexes neural speed or brain efficiency. The P300 amplitude might index neural power or cognitive resources, which increase with maturation.

Blood pressure levels in male carriers of Arg82Cys in CD300LG

DEFF Research Database (Denmark)

Støy, Julie; Grarup, Niels; Hørlyck, Arne

2014-01-01

found to be associated with fasting HDL-cholesterol and triglyceride levels. The polymorphism has not been detected in hypertension GWAS potentially due to its low frequency, but CD300LG has been linked to blood pressure as CD300LG knockout mice have changes in blood pressure. Twenty......-four-hour ambulatory blood pressure was obtained in human CD300LG CT-carriers to follow up on these observations. METHODS: Twenty healthy male CD300LG rs72836561 CT-carriers matched for age and BMI with 20 healthy male CC-carriers. Office blood pressure, 24-hour ambulatory blood pressure, carotid intima......-media thickness (CIMT), and fasting blood samples were evaluated. The clinical study was combined with a genetic-epidemiological study to replicate the association between blood pressure and CD300LG Arg82Cys in 2,637 men and 3,249 women. RESULTS: CT-carriers had a higher 24-hour ambulatory systolic blood pressure...

p300 expression repression by hypermethylation associated with tumour invasion and metastasis in oesophageal squamous cell carcinoma

Science.gov (United States)

Zhang, Changsong; Li, Ke; Wei, Lixin; Li, Zhengyou; Yu, Ping; Teng, Lijuan; Wu, Kusheng; Zhu, Jin

2007-01-01

Background Aberrant promoter methylation is an important mechanism for gene silencing. Aims To evaluate the promoter methylation status of p300 gene in patients with oesophageal squamous cell carcinoma (OSCC). Methods The methylation status of p300 promoter was analysed by methylation‐specific PCR (MSP) in 50 OSCC tissues and the matching non‐cancerous tissues. Oesophageal cancer cell lines (ECa‐109 and TE‐10) were treated with the demethylation agent 5‐aza‐2′‐deoxycytidine (5‐Aza‐CdR), and p300 mRNA expression was detected by RT‐PCR. Results p300 methylation was found in 42% (21/50) of the OSCC tissues, but in only 20% (10/50) of the corresponding non‐cancerous tissues (p = 0.017). In OSCC samples, 65% of those with deep tumour invasion (adventitia) and 63% samples with metastasis revealed p300 promoter methylation (p<0.05). p300 mRNA expression was observed in 19.0% (4/21) of methylated tumours and 58.6% (17/29) of unmethylated tumours (p = 0.005). In addition, p300 mRNA expression was observed in 40% (4/10) of methylated non‐neoplastic tissues and 87.5% (35/40) of unmethylated non‐tumours (p = 0.001). The demethylation caused by 5‐Aza‐CdR increased the p300 mRNA expression levels in oesophageal cancer cell lines. Conclusions p300 transcription silenced by promoter hypermethylation could play a role in the pathogenesis of oesophageal squamous cell carcinoma. PMID:17965222

Waste resources utilization program. Interim report, June 30, 1976

International Nuclear Information System (INIS)

1976-07-01

This is an interim report on the effects of the combined use of heat and ionizing radiation (thermoradiation) as a treatment for ridding sewage sludge of pathogenic organisms as well as its effect on the physical-chemical properties. This activity couples two major environmental problems, disposition of human and of nuclear waste, in an attempt to provide a framework in which both will become useful resources. This combined treatment might be chosen to inactivate both heat labile (but possibly radiation resistant) and radiation labile (but possibly heat resistant) organisms. The cost-effective analyses of such a treatment are being examined. Sludge treated with thermoradiation offers considerable potential for use as a fertilizer in agriculture or a soil conditioner for land reclamation free of the potential health hazards associated with conventional methods of land disposal. Treated sludge may also provide a low-cost substitute for high-nutritional components in ruminant diets

Basic design and economical evaluation of Gas Turbine High Temperature Reactor 300 (GTHTR300)

International Nuclear Information System (INIS)

Kazuhiko, Kunitomi; Shusaku, Shiozawa; Xing, Yan

2007-01-01

High Temperature Gas-cooled Reactor (HTGR) combined with a direct cycle gas turbine offers one of the most promising nuclear electricity generation options after 2010. Japan Atomic Energy Agency has been engaging in the basic design and development of Gas Turbine High Temperature Reactor 300 (GTHTR300) since 2003. Costs of capital, fuel, and operation and maintenance have been estimated. The capital cost of the GTHTR300 is lower than that of the existing light water reactor (LWR) because the generation efficiency is considerably higher whereas the construction cost is lower owing to the design simplicity of the gas turbine power conversion unit and the reactor safety system. The fuel cost is shown to equal that of LWR. The operation and maintenance cost has a slight advantage due to the use of chemically inert helium coolant. In sum, the cost of electricity for the GTHTR300 is estimated to be below US 3.3 cents/kWh (4 yen/kWh), which is about two-third of that of current LWRs in Japan. The results confirm that the net power generation cost of the GTHTR300 is much lower than that of the LWR, indicating that the GTHTR300 plant consisting of small-scale reactor units can be economically competitive to the latest large-scale LWR. (authors)

A study on the cerebral dominance and the origin of P300 using acoustic P300 and single photon emission computed tomography in normal volunteers

International Nuclear Information System (INIS)

Sato, Kenichi

1994-01-01

P300 is one of the late positive component of event related potentials. Its latency is around 300 ms following in frequent stimuli. P300 components are evident only in response to the target stimuli and are thought to reflect the speed of stimulus evaluation and categorization. Thus, abnormalities of P300 component may be expected in disorders which are characterised by cognitive slowing. Recently, P300 has been used in the assessment of cognitive function for many diseases such as dementia or cerebrovascular disease. However, the origin of P300 is still unknown. In this study, to investigate the superiority of hemisphere and the origin of P300, P300 assessment and SPECT were performed in normal subjects. An auditory oddball paradigm was used to elicit the P300 components in 40 normal volunteers (15 to 77 years). P300 peak latency and peak-to-peak amplitude of N200 and P300 were measured from Cz (midline), C3 (left side), and C4 (right side) using the International 10-20 System. 123 I-IMP-SPECT was studied in 7 normal volunteers (26 to 56 years) in conjunction with auditory P300 stimulation. Right-Left ratios of count rates of both hemispheres and ROI (region of interest) setting in frontal lobe, temporal lobe, basal ganglia, and cerebellum were calculated, and the following results were obtained. P300 latency was significantly decreased in Cz and C4 compared with C3. P300 amplitude was significantly increased in Cz and C4 compared with C3. Cerebral blood flow increase in the right hemisphere was observed in 5 of the 7 subjects that underwent auditory P300 stimulation. Right-Left ratio of count rates showed over 1 in the temporal lobe and basal ganglia. The above results suggested that auditory P300 showed right hemisphere superiority, and that the temporal lobe and basal ganglia may be especially important to the origin of P300. (author)

Silicon based ultrafast optical waveform sampling

DEFF Research Database (Denmark)

Ji, Hua; Galili, Michael; Pu, Minhao

2010-01-01

A 300 nmx450 nmx5 mm silicon nanowire is designed and fabricated for a four wave mixing based non-linear optical gate. Based on this silicon nanowire, an ultra-fast optical sampling system is successfully demonstrated using a free-running fiber laser with a carbon nanotube-based mode-locker as th......A 300 nmx450 nmx5 mm silicon nanowire is designed and fabricated for a four wave mixing based non-linear optical gate. Based on this silicon nanowire, an ultra-fast optical sampling system is successfully demonstrated using a free-running fiber laser with a carbon nanotube-based mode......-locker as the sampling source. A clear eye-diagram of a 320 Gbit/s data signal is obtained. The temporal resolution of the sampling system is estimated to 360 fs....

34 CFR 300.122 - Evaluation.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children with...

The effect of Cissus quadrangularis (CQR-300 and a Cissus formulation (CORE on obesity and obesity-induced oxidative stress

Directory of Open Access Journals (Sweden)

Agbor Gabriel A

2007-02-01

Full Text Available Abstract Aim Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300 to that of a proprietary formulation containing CQR-300 (CORE on weight, blood lipids, and oxidative stress in overweight and obese people. Methods The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19–54, of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period. Results CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p Conclusion CQR-300 (300 mg daily and CORE (1028 mg daily brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

Delisting petition for 300-M saltstone (treated F006 sludge) from the 300-M liquid effluent treatment facility

Energy Technology Data Exchange (ETDEWEB)

1989-04-04

This petition seeks exclusion for stabilized and solidified sludge material generated by treatment of wastewater from the 300-M aluminum forming and metal finishing processes. The waste contains both hazardous and radioactive components and is classified as a mixed waste. The objective of this petition is to demonstrate that the stabilized sludge material (saltstone), when properly disposed, will not exceed the health-based standards for the hazardous constituents. This petition contains sampling and analytical data which justify the request for exclusion. The results show that when the data are applied to the EPA Vertical and Horizontal Spread (VHS) Model, health-based standards for all hazardous waste constituents will not be exceeded during worst case operating and environmental conditions. Disposal of the stabilized sludge material in concrete vaults will meet the requirements pertaining to Waste Management Activities for Groundwater Protection at the Savannah River Site in Aiken, S.C. Documents set forth performance objectives and disposal options for low-level radioactive waste disposal. Concrete vaults specified for disposal of 300-M saltstone (treated F006 sludge) assure that these performance objectives will be met.

34 CFR 300.307 - Specific learning disabilities.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Specific learning disabilities. 300.307 Section 300.307... Educational Placements Additional Procedures for Identifying Children with Specific Learning Disabilities § 300.307 Specific learning disabilities. (a) General. A State must adopt, consistent with § 300.309...

34 CFR 300.36 - Secondary school.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Secondary school. 300.36 Section 300.36 Education... DISABILITIES General Definitions Used in This Part § 300.36 Secondary school. Secondary school means a nonprofit institutional day or residential school, including a public secondary charter school that provides...

11 CFR 300.35 - Office buildings.

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2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false Office buildings. 300.35 Section 300.35 Federal... FUNDS State, District, and Local Party Committees and Organizations § 300.35 Office buildings. (a) General provision. For the purchase or construction of its office building, a State or local party...

50 CFR 300.104 - Scientific research.

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2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Scientific research. 300.104 Section 300... REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management measures... vessel for research purposes, unless otherwise indicated. (b) Catches taken by any vessel for research...

24 CFR 300.9 - Office.

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2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Office. 300.9 Section 300.9 Housing... NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.9 Office. The Association directs its operations from its office located at 451 Seventh Street, SW., Washington DC 20410. ...

30 CFR 250.300 - Pollution prevention.

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2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pollution prevention. 250.300 Section 250.300... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a... pollution occurs as a result of operations conducted by or on behalf of the lessee and the pollution damages...

49 CFR 179.300-9 - Welding.

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2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Welding. 179.300-9 Section 179.300-9... Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-9 Welding. (a) Longitudinal... fusion welded on class DOT-110A tanks. Welding procedures, welders and fabricators must be approved in...

46 CFR 181.300 - Fire pumps.

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2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD... EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must be..., the minimum capacity of the fire pump must be 189 liters (50 gallons) per minute at a pressure of not...

34 CFR 300.505 - Electronic mail.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Electronic mail. 300.505 Section 300.505 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.505 Electronic mail. A....508 by an electronic mail communication, if the public agency makes that option available. (Authority...

34 CFR 300.606 - Public attention.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Public attention. 300.606 Section 300.606 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND..., and Enforcement § 300.606 Public attention. Whenever a State receives notice that the Secretary is...

34 CFR 300.512 - Hearing rights.

Science.gov (United States)

2010-07-01

... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.512 Hearing rights. (a... 34 Education 2 2010-07-01 2010-07-01 false Hearing rights. 300.512 Section 300.512 Education...

34 CFR 300.13 - Elementary school.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Elementary school. 300.13 Section 300.13 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.13 Elementary school. Elementary school means a...

9 CFR 300.3 - FSIS organization.

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2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false FSIS organization. 300.3 Section 300.3... ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION AGENCY MISSION AND ORGANIZATION § 300.3 FSIS organization. (a) General. The organization of FSIS...

34 CFR 300.105 - Assistive technology.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those terms...

34 CFR 300.4 - Act.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Act. 300.4 Section 300.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... Definitions Used in This Part § 300.4 Act. Act means the Individuals with Disabilities Education Act, as...

34 CFR 300.40 - State.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false State. 300.40 Section 300.40 Education Regulations of... SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.40 State. State means each of the 50 States, the District of...

34 CFR 300.321 - IEP Team.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not less...

34 CFR 300.519 - Surrogate parents.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Surrogate parents. 300.519 Section 300.519 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.519 Surrogate parents... parent (as defined in § 300.30) can be identified; (2) The public agency, after reasonable efforts...

34 CFR 300.29 - Native language.

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2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Native language. 300.29 Section 300.29 Education... DISABILITIES General Definitions Used in This Part § 300.29 Native language. (a) Native language, when used with respect to an individual who is limited English proficient, means the following: (1) The language...

46 CFR 177.300 - Structural design.

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2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Structural design. 177.300 Section 177.300 Shipping...) CONSTRUCTION AND ARRANGEMENT Hull Structure § 177.300 Structural design. Except as otherwise allowed by this subpart, a vessel must comply with the structural design requirements of one of the standards listed below...

34 CFR 300.111 - Child find.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH... child with a disability under § 300.8 and in need of special education, even though they are advancing...

Geohydrology and ground-water quality beneath the 300 Area, Hanford Site, Washington

International Nuclear Information System (INIS)

Lindberg, J.W.; Bond, F.W.

1979-06-01

Ground water enters the 300 Area from the northwest, west, and southwest. However, throughout most of the 300 Area, the flow is to the east and southeast. Ground water flows to the northeast only in the southern portion of the 300 Area. Variations in level of the Columbia River affected the ground-water system by altering the level and shape of the 300 Area watertable. Large quantities of process waste water, when warmed during summer months by solar radiation or cooled during winter months by ambient air temperature, influenced the temperature of the ground water. Leaking pipes and the intentional discharge of waste water (or withdrawal of ground water) affected the ground-water system in the 300 Area. Water quality tests of Hanford ground water in and adjacent to the 300 Area showed that in the area of the Process Water Trenches and Sanitary Leaching Trenches, calcium, magnesium, sodium, bicarbonate, and sulfate ions are more dilute, and nitrate and chloride ions are more concentrated than in surrounding areas. Fluoride, uranium, and beta emitters are more concentrated in ground water along the bank of the Columbia River in the central and southern portions of the 300 Area and near the 340 Building. Test wells and routine ground-water sampling are adequate to point out contamination. The variable Thickness Transient (VTT) Model of ground-water flow in the unconfined aquifer underlying the 300 Area has been set up, calibrated, and verified. The Multicomponent Mass Transfer (MMT) Model of distribution of contaminants in the saturated regime under the 300 Area has been set up, calibrated, and tested

46 CFR 116.300 - Structural design.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Structural design. 116.300 Section 116.300 Shipping... Structure § 116.300 Structural design. Except as otherwise allowed by this subpart, a vessel must comply with the structural design requirements of one of the standards listed below for the hull material of...

29 CFR 99.300 - Auditee responsibilities.

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Auditee responsibilities. 99.300 Section 99.300 Labor Office... § 99.300 Auditee responsibilities. The auditee shall: (a) Identify, in its accounts, all Federal awards... the schedule of expenditures of Federal awards in accordance with § 99.310. (e) Ensure that the audits...

34 CFR 300.625 - Children's rights.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Children's rights. 300.625 Section 300.625 Education... § 300.625 Children's rights. (a) The SEA must have in effect policies and procedures regarding the extent to which children are afforded rights of privacy similar to those afforded to parents, taking into...

Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a.

Science.gov (United States)

DeBell, Karen E; Simhadri, Venkateswara R; Mariano, John L; Borrego, Francisco

2012-04-26

Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM bearing type I transmembrane protein, is expressed on many hematopoietic cells, including subsets of lymphocytes. We have taken two approaches to further define the mechanism by which CD300a acts as an inhibitor of immune cell receptor signaling. First, we have expressed in Jurkat T cells a chimeric receptor consisting of the extracellular domains of killer-cell immunoglobulin-like receptor (KIR)2DL2 fused to the transmembrane and cytoplasmic segments of CD300a (KIR-CD300a) to explore surrogate ligand-stimulated inhibition of superantigen stimulated T cell receptor (TCR) mediated cell signaling. We found that intact CD300a ITIMs were essential for inhibition and that the tyrosine phosphorylation of these ITIMs required the src tyrosine kinase Lck. Tyrosine phosphorylation of the CD300a ITIMs created docking sites for both src homology 2 domain containing protein tyrosine phosphatase (SHP)-1 and SHP-2. Suppression of SHP-1 and SHP-2 expression in KIR-CD300a Jurkat T cells with siRNA and the use of DT40 chicken B cell lines expressing CD300a and deficient in several phosphatases revealed that SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5' phosphatase SHIP, was utilized by CD300a for its inhibitory activity. These studies provide new insights into the function of CD300a in tuning T and B cell responses.

21 CFR 73.300 - Carrot oil.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot oil is the liquid or the solid portion of the mixture or the mixture itself obtained by the hexane...

Low cycle fatigue behavior of polycrystalline NiAl at 300 and 1000 K

Science.gov (United States)

Lerch, Bradley A.; Noebe, Ronald D.

1993-01-01

The low cycle fatigue behavior of polycrystalline NiAl was determined at 300 and 1000 K - temperatures below and above the brittle- to-ductile transition temperature (BDTT). Fully reversed, plastic strain-controlled fatigue tests were conducted on two differently fabricated alloy samples: hot isostatically pressed (HIP'ed) prealloyed powder and hot extruded castings. HIP'ed powder (HP) samples were tested only at 1000 K, whereas the more ductile cast-and-extruded (C+E) NiAl samples were tested at both 1000 and 300 K. Plastic strain ranges of 0.06 to 0.2 percent were used. The C+E NiAl cyclically hardened until fracture, reaching stress levels approximately 60 percent greater than the ultimate tensile strength of the alloy. Compared on a strain basis, NiAl had a much longer fatigue life than other B2 ordered compounds in which fracture initiated at processing-related defects. These defects controlled fatigue life at 300 K, with fracture occurring rapidly once a critical stress level was reached. At 1000 K, above the BDTT, both the C+E and HP samples cyclically softened during most of the fatigue tests in air and were insensitive to processing defects. The processing method did not have a major effect on fatigue life; the lives of the HP samples were about a factor of three shorter than the C+E NiAl, but this was attributed to the lower stress response of the C+E material. The C+E NiAl underwent dynamic grain growth, whereas the HP material maintained a constant grain size during testing. In both materials, fatigue life was controlled by intergranular cavitation and creep processes, which led to fatigue crack growth that was primarily intergranular in nature. Final fracture by overload was transgranular in nature. Also, HP samples tested in vacuum had a life three times longer than their counterparts tested in air and, in contrast to those tested in air, hardened continuously over half of the sample life, thereby indicating an environmentally assisted fatigue damage

75 FR 28480 - Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A300 B4-600, B4-600R, F4-600R...

Science.gov (United States)

2010-05-21

... Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A300 B4-600, B4-600R, F4-600R Series..., B4-622, B4- 605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F airplanes; and Model A310-203...

Isotopic Tracking of Hanford 300 Area Derived Uranium in the Columbia River

Energy Technology Data Exchange (ETDEWEB)

Christensen, John N.; Dresel, P. Evan; Conrad, Mark E.; Patton, Gregory W.; DePaolo, Donald J.

2010-10-31

Our objectives in this study are to quantify the discharge rate of uranium (U) to the Columbia River from the Hanford Site's 300 Area, and to follow that U down river to constrain its fate. Uranium from the Hanford Site has variable isotopic composition due to nuclear industrial processes carried out at the site. This characteristic makes it possible to use high-precision isotopic measurements of U in environmental samples to identify even trace levels of contaminant U, determine its sources, and estimate discharge rates. Our data on river water samples indicate that as much as 3.2 kg/day can enter the Columbia River from the 300 Area, which is only a small fraction of the total load of dissolved natural background U carried by the Columbia River. This very low-level of Hanford derived U can be discerned, despite dilution to < 1 percent of natural background U, 350 km downstream from the Hanford Site. These results indicate that isotopic methods can allow the amounts of U from the 300 Area of the Hanford Site entering the Columbia River to be measured accurately to ascertain whether they are an environmental concern, or are insignificant relative to natural uranium background in the Columbia River.

300 Area Disturbance Report

Energy Technology Data Exchange (ETDEWEB)

LL Hale; MK Wright; NA Cadoret

1999-01-07

The objective of this study was to define areas of previous disturbance in the 300 Area of the U.S. Department of Energy (DOE) Hanford Site to eliminate these areas from the cultural resource review process, reduce cultural resource monitoring costs, and allow cultural resource specialists to focus on areas where subsurface disturbance is minimal or nonexistent. Research into available sources suggests that impacts from excavations have been significant wherever the following construction activities have occurred: building basements and pits, waste ponds, burial grounds, trenches, installation of subsurface pipelines, power poles, water hydrants, and well construction. Beyond the areas just mentioned, substrates in the' 300 Area consist of a complex, multidimen- sional mosaic composed of undisturbed stratigraphy, backfill, and disturbed sediments; Four Geographic Information System (GIS) maps were created to display known areas of disturbance in the 300 Area. These maps contain information gleaned from a variety of sources, but the primary sources include the Hanford GIS database system, engineer drawings, and historic maps. In addition to these maps, several assumptions can be made about areas of disturbance in the 300 Area as a result of this study: o o Buried pipelines are not always located where they are mapped. As a result, cultural resource monitors or specialists should not depend on maps depicting subsurface pipelines for accurate locations of previous disturbance. Temporary roads built in the early 1940s were placed on layers of sand and gravel 8 to 12 in. thick. Given this information, it is likely that substrates beneath these early roads are only minimally disturbed. Building foundations ranged from concrete slabs no more than 6 to 8 in. thick to deeply excavated pits and basements. Buildings constructed with slab foundations are more numerous than may be expected, and minimally disturbed substrates may be expected in these locations. Historic

100 Area and 300 Area Component of the River Corridor Baseline Risk Assessment Spring 2006 Data Compilation

Energy Technology Data Exchange (ETDEWEB)

J. M. Queen; S. G. Weiss

2006-11-20

The purpose of this report is to describe the sampling approaches, modifications made to the 100 Area and 300 Area component of the RCBRA Sampling and Analysis Plan, summarize validation efforts, and provide sample identification numbers.

100 Area and 300 Area Component of the River Corridor Baseline Risk Assessment Spring 2006 Data Compilation

International Nuclear Information System (INIS)

Queen, J.M.; Weiss, S.G.

2006-01-01

The purpose of this report is to describe the sampling approaches, modifications made to the 100 Area and 300 Area component of the RCBRA Sampling and Analysis Plan, summarize validation efforts, and provide sample identification numbers.

New Cepheid distances to nearby galaxies based on BVRI CCD photometry. III - NGC 300

Energy Technology Data Exchange (ETDEWEB)

Freedman, W.L.; Madore, B.F.; Hawley, S.L.; Horowitz, I.K.; Mould, J.; Navarrete, M.; Sallmen, S. (Carnegie Institution of Washington, Observatories, Pasadena, CA (United States) JPL, Pasadena, CA (United States) Lawrence Livermore National Laboratory, Livermore, CA (United States) California Institute of Technology, Pasadena (United States) Cerro Tololo Inter-American Observatory, La Serena (Chile) California, University, Berkeley (United States))

1992-09-01

A true distance modulus of (m - M) sub 0 = 26.66 +/- 0.10 mag (corresponding to 2.1 +/- 0.1 Mpc) has been determined for the Sculptor Group spiral galaxy NGC 300. New CCD data have been obtained for a sample of known Cepheids in this galaxy from which apparent distance moduli at B, V, R, and I wavelengths are determined. Combining the data available at different wavelenghts, and assuming a true distance modulus to the LMC of 18.5 mag, a true distance modulus is obtained for NGC 300, corrected for the effects of interstellar reddening. The availability of a new distance to NGC 300 brings to five the total number of galaxies with new CCD photometry of Cepheids, useful for calibration of the Hubble constant. 26 refs.

34 CFR 300.15 - Evaluation.

Science.gov (United States)

2010-07-01

... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH... extent of the special education and related services that the child needs. (Authority: 20 U.S.C. 1414(a... 34 Education 2 2010-07-01 2010-07-01 false Evaluation. 300.15 Section 300.15 Education Regulations...

34 CFR 300.22 - Individualized education program.

Science.gov (United States)

2010-07-01

... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.22 Individualized education program. Individualized education program or IEP means a written statement for a child with a disability that is developed... 34 Education 2 2010-07-01 2010-07-01 false Individualized education program. 300.22 Section 300.22...

rDNA insulin glargine U300 – a critical appraisal

Directory of Open Access Journals (Sweden)

Wang F

2016-12-01

Full Text Available Fei Wang,1 Stefanie Zassman,1 Philip A Goldberg2 1Department of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs, CT, USA; 2Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT, USA Background: As the first once-daily basal insulin analog, insulin glargine 100 U/mL (Gla‑100; Lantus® rapidly evolved into the most commonly prescribed insulin therapy worldwide. However, this insulin has clinical limitations. The approval of new basal insulin analogs in 2015 has already started to alter the prescribing landscape.Objective: To review the available evidence on the clinical efficacy and safety of a more concentrated insulin glargine (recombinant DNA origin injection 300 U/mL (Gla-300 compared to insulin Gla-100 in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM.Methods: The following electronic databases were searched: PubMed and MEDLINE (using Ovid platform, Scopus, BIOSIS, and Google Scholar through June 2016. Conference proceedings of the American Diabetes Association (2015–2016 were reviewed. We also manually searched reference lists of pertinent reviews and trials.Results: A total of 6 pivotal Phase III randomized controlled trials known as the EDITION series were reviewed. All of these trials (n=3,500 were head-to-head comparisons evaluating the efficacy and tolerability of Gla-300 vs Gla-100 in a diverse population with T1DM and T2DM. These trials were of 6 months duration with a 6-month safety extension phase.Conclusion: Gla-300 was as effective as Gla-100 for improving glycemic control over 6 months in all studies, with a lower risk of nocturnal hypoglycemia significant only in insulin-experienced patients with T2DM. Overall, patients on Gla-300 required 10%–18% more basal insulin, but with less weight gain compared with Gla-100. Keywords: basal insulin, glargine 300 U/mL, glargine 100 U/mL

Safety design of SNR-300

International Nuclear Information System (INIS)

Traube, K.

1976-01-01

The joint German-Belgian-Dutch loop-type 300 MW(e) LMFBR prototype is being constructed at Kalkar on the lower Rhine in Germany. Among the many arguments put forward in defense of SNR-300, that of acquiring licensing exprience has proven to be of major importance to the international breeder scene. The severity of the licensing procedures and of the safety standards imposed are unique in several respects, including timing: generally growing scepticism towards nuclear power increased severity of the licensing practice; organizational features: the procedure and criteria developed for commercial light water reactors have been applied without exemptions. This relates to the commercial-type contract under which SNR-300 is being built for private utilities by a private company; and German nuclear safety standards, known worldwide to be most stringent. The following three important areas are discussed in which SNR-300 decidedly deviates from its forerunners: protection against the hypothetical core disruptive accident (HCDA), protection against external events, and provisions for in-service inspection

50 CFR 300.37 - Radio monitoring.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Radio monitoring. 300.37 Section 300.37 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.37 Radio monitoring. The international distress frequency, 2.182 mHz...

Estimation of the Operating Characteristics When the Test Information of the Old Test Is Not Constant. II. Simple Sum Procedure of the Conditional P.D.F. Approach/Normal Approach Method Using Three Subtests of the Old Test, Number 2

Science.gov (United States)

1981-07-01

discrimination parameter and b isg x g the item response difficulty parameter which satisfies (2.3) - b b1 b1 ...Acquisitions School of Education 4333 Rugby Avenue University of Massechusetts Bethesda, MD 20014 Amherst, MA 01002 1V -127- Non Govt Non Govt 1 Dr. Chester

34 CFR 300.110 - Program options.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Program options. 300.110 Section 300.110 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Other Fape Requirements § 300.110 Program options. The State must ensure that...

34 CFR 300.19 - Homeless children.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has the...

Golden Eagle Territories and Ecology at Site 300

Energy Technology Data Exchange (ETDEWEB)

Fratanduono, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-09-29

Garcia and Associates (GANDA) was contracted by the Lawrence Livermore National Laboratory (LLNL) to collect information on golden eagle (Aquila chrysaetos) use of Site 300. During 2014, we conducted surveys at Site 300 and for an area including a 10-mile radius of Site 300. Those surveys documented 42 golden eagle territories including two territories that overlapped with Site 300. These were named ‘Tesla’ and ‘Linac Road’. In 2015, we conducted surveys to refine the territory boundaries of golden eagle territories that overlapped with Site 300 and to document eagle activity at Site 300.

Effects of Forest Regeneration on Crickets: Evaluating Environmental Drivers in a 300-Year Chronosequence

Directory of Open Access Journals (Sweden)

Neucir Szinwelski

2012-01-01

Full Text Available We evaluated the relation of cricket species richness and composition with forest regeneration time, evaluating canopy and litter depth as environmental drivers. Effects of forest patch area, nearest distance to the 300-year patch, cricket abundance, sampling sufficiency, and nestedness were also evaluated. We collected 1174 individuals (five families, 19 species. Species richness increased asymptotically with regeneration time and linearly with canopy cover and litter depth. Canopy cover increased linearly, while litter depth increased asymptotically. Richness was not affected by patch area and nearest distance to the 300-year patch. Richness increased with cricket abundance, and this explanation could not be distinguished from regeneration time, evidencing collinearity of these two explanatory variables. Rarefaction curve slopes increased with regeneration time. Species composition differed among patches, with no nested pattern. We suggest that regeneration and consequent increases in canopy and litter promote recovery of cricket biodiversity, abundance, and changes in species composition. We conclude that the recovery of cricket diversity involves an increase along the spatial scale of complementarity, together with a change in species composition.

300 Area Process Trenches Postclosure Plan

International Nuclear Information System (INIS)

Badden, J.W.

1998-05-01

The 300 Area Process Trenches (300 APT) certified closure under a modified closure option and in compliance with Condition II.K.3 oft he Hartford Facility Dangerous Waste Permit (Penit) (Ecology 1994). Modified closure has been determined to be the appropriate closure option for this unit due to groundwater that remains contaminated from past operations at the 300 APT. Corrective actions required for dangerous waste constituents remaining in groundwater will occur pursuant to the 300 APT Resource Conservation and Recovery Act (RCRA) Final Status Facility Ground Water Monitoring Plan, the Hanford Site Wide Dangerous Waste Permit, and in conjunction with the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) remedial actions at the 300-FF-5 Groundwater Operable Unit (OU) pursuant to the Record of Decision (ROD) (EPA 1996). This postclosure plan identifies the modified closure actions required at the unit under postclosure care. It contains a description of the unit, past closure actions, and postclosure care requirements subject to compliance under the Permit (condition II.K.3)

34 CFR 300.44 - Universal design.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the meaning...

34 CFR 300.7 - Charter school.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Charter school. 300.7 Section 300.7 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.7 Charter school. Charter school has the meaning given...

300 Area Process Trenches Modified Closure/Postclosure Plan

International Nuclear Information System (INIS)

1997-09-01

This chapter provides a brief summary of the contents of each chapter of this plan for the closure of the 300 Area Process Trenches (300 APT) treatment, storage, and/or disposal unit. It also provides background information for this unit and discusses how its closure will be integrated with the remedial action for the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 300- FF-1 Operable Unit. The 300 APT is located within the 300 Area of the Hanford Site. This area contained reactor fuel fabrication facilities and research and development laboratories. The 300 APT was constructed and began operations in 1975 as the 316-5 Process Trenches. Effluent was discharged to the trenches by way of the 300 Area process sewer system, which has been the sole source of effluent for the 300 APT. The 316-5 Process Trenches gained Resource Conservation and Recovery Act of 1976 (RCRA) interim status as the 300 APT TSD unit on November 11, 1985. The unit has been administratively closed to discharges of dangerous waste since 1985

40 CFR 300.110 - National Response Team.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false National Response Team. 300.110... PLAN Responsibility and Organization for Response § 300.110 National Response Team. National planning... agencies named in § 300.175(b). Each agency shall designate a member to the team and sufficient alternates...

34 CFR 300.16 - Excess costs.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Excess costs. 300.16 Section 300.16 Education... DISABILITIES General Definitions Used in This Part § 300.16 Excess costs. Excess costs means those costs that... for an example of how excess costs must be calculated.) (Authority: 20 U.S.C. 1401(8)) ...

34 CFR 300.612 - Notice to parents.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Notice to parents. 300.612 Section 300.612 Education... § 300.612 Notice to parents. (a) The SEA must give notice that is adequate to fully inform parents about... parents and children regarding this information, including the rights under FERPA and implementing...

50 CFR 300.40 - Civil penalties.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Civil penalties. 300.40 Section 300.40... South Pacific Tuna Fisheries § 300.40 Civil penalties. The procedures of 15 CFR part 904 apply to the assessment of civil penalties, except as modified by the requirements of section 8 of the Act. ...

The utility of P300 as a schizophrenia endophenotype and predictive biomarker: clinical and socio-demographic modulators in COGS-2.

Science.gov (United States)

Turetsky, Bruce I; Dress, Erich M; Braff, David L; Calkins, Monica E; Green, Michael F; Greenwood, Tiffany A; Gur, Raquel E; Gur, Ruben C; Lazzeroni, Laura C; Nuechterlein, Keith H; Radant, Allen D; Seidman, Larry J; Siever, Larry J; Silverman, Jeremy M; Sprock, Joyce; Stone, William S; Sugar, Catherine A; Swerdlow, Neal R; Tsuang, Debby W; Tsuang, Ming T; Light, Gregory

2015-04-01

Reduced auditory P300 amplitude is a robust schizophrenia deficit exhibiting the qualities of a viable genetic endophenotype. These include heritability, test-retest reliability, and trait-like stability. Recent evidence suggests that P300 may also serve as a predictive biomarker for transition to psychosis during the schizophrenia prodrome. Historically, the utility of the P300 has been limited by its clinical nonspecificity, cross-site measurement variability, and required EEG expertise. The Consortium on the Genetics of Schizophrenia (COGS-2) study provided an opportunity to examine the consistency of the measure across multiple sites with varying degrees of EEG experience, and to identify important modulating factors that contribute to measurement variability. Auditory P300 was acquired from 649 controls and 587 patients at 5 sites. An overall patient deficit was observed with effect size 0.62. Each site independently observed a significant patient deficit, but site differences also existed. In patients, site differences reflected clinical differences in positive symptomatology and functional capacity. In controls, site differences reflected differences in racial stratification, smoking and substance use history. These factors differentially suppressed the P300 response, but only in control subjects. This led to an attenuated patient-control difference among smokers and among African Americans with history of substance use. These findings indicate that the P300 can be adequately assessed quantitatively, across sites, without substantial EEG expertise. Measurements are suitable for both genetic endophenotype analyses and studies of psychosis risk and conversion. However, careful attention must be given to selection of appropriate comparison samples to avoid misleading false negative results. Copyright © 2014 Elsevier B.V. All rights reserved.

Design of a 300 GHZ broadband coupler and RF-structure

International Nuclear Information System (INIS)

Krawczyk, F.L.; Carlsten, B.E.; Earley, L.M.; Sigler, F.E.; Potter, J.M.; Schulze, M.E.

2004-01-01

Recent LANL activities in millimeter wave structures focus on 95 and 300 GHz structures. They aim at power generation from low power (100W-2kW) with a round electron beam (120kV, 0.1-1.0 A) to high power (2-100 kW) with a sheet beam structure (120 kV, 20 A). Applications cover basic research, radar and secure communications and remote sensing of biological and chemical agents. In this presentation the design of a 300 GHz RF-structure with a broadband (> 6% bandwidth) power coupler is presented. The choice of two input/output waveguides, a special coupling region and the structure parameters are presented. As a benchmark also a scaled up version at 10 GHz was designed and measured. These results will also be presented. We are investigating planar micro-fabricated traveling-wave tube amplifiers as sources for the generation of millimeter waves from 95 to 300 GHz. While for low energy applications narrow structures with pencil beams are proposed, for high energy operation flat, thin sheet beams are required. For the latter vane-loaded rectangular waveguides that operate in a slow-wave mode matched to the velocity of the electron beam are especially well suited. The 300 GHz effort initially is limited to narrow structures for pencil beams. The main emphasis for this work are the study of fabrication issues and the understanding of features that allow a broadband operation (5-10% bandwidth).

34 CFR 300.326 - [Reserved

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false [Reserved] 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

50 CFR 300.181 - Definitions.

Science.gov (United States)

2010-10-01

... Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS International Trade Documentation and Tracking Programs for Highly Migratory Species § 300.181 Definitions... international trade permit under § 300.182. [61 FR 35550, July 5, 1996, as amended at 73 FR 31385, June 2, 2008] ...

40 CFR 158.300 - Definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Definitions. 158.300 Section 158.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS DATA REQUIREMENTS... substances, if specified by the Agency) that will prevent, destroy, repel or mitigate any pest, or that...

17 CFR 300.101 - Individual accounts.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Individual accounts. 300.101... Customers of Sipc Members § 300.101 Individual accounts. (a) Except as otherwise provided in these rules... deemed his individual accounts, shall be combined so as to constitute a single account of a separate...

OGJ300

International Nuclear Information System (INIS)

Beck, R.J.; Biggs, J.B.

1991-01-01

This paper reports on Oil and Gas Journal's list of the largest, publicly traded oil and gas producing companies in the U.S. which is both smaller and larger this year than it was in 1990. It's smaller because it covers fewer companies. Industry consolidation has slashed the number of public companies. As a result, the former OGJ400 has become the OGJ300, which includes the 30 largest limited partnerships. But the assets-ranked list is larger because important financial totals - representing 1990 results - are significantly higher than those of a year ago, despite the lower number of companies. Consolidation of the U.S. producing industry gained momentum throughout the 1980s. Unable to sustain profitability in a period of sluggish energy prices and, for many, rising costs, companies sought relief through mergers or liquidation of producing properties. As this year's list shows, however, surviving companies have managed to grow. Assets for the OGJ300 group totaled $499.3 billion in 1990 - up 6.3% from the 1989 total of last year's OGJ400. Stockholders' equity moved up 5.3% to $170.7 billion. Stockholders' equity was as high as $233.8 billion in 1983

Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.

Science.gov (United States)

Fu, Maofu; Wang, Chenguang; Rao, Mahadev; Wu, Xiaofang; Bouras, Toula; Zhang, Xueping; Li, Zhiping; Jiao, Xuanmao; Yang, Jianguo; Li, Anping; Perkins, Neil D; Thimmapaya, Bayar; Kung, Andrew L; Munoz, Alberto; Giordano, Antonio; Lisanti, Michael P; Pestell, Richard G

2005-08-19

Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma protein. In addition to its Cdk binding-dependent functions, cyclin D1 regulates cellular differentiation in part by modifying several transcription factors and nuclear receptors. The molecular mechanism through which cyclin D1 regulates the function of transcription factors involved in cellular differentiation remains to be clarified. The histone acetyltransferase protein p300 is a co-integrator required for regulation of multiple transcription factors. Here we show that cyclin D1 physically interacts with p300 and represses p300 transactivation. We demonstrated further that the interaction of the two proteins occurs at the peroxisome proliferator-activated receptor gamma-responsive element of the lipoprotein lipase promoter in the context of the local chromatin structure. We have mapped the domains in p300 and cyclin D1 involved in this interaction. The bromo domain and cysteine- and histidine-rich domains of p300 were required for repression by cyclin D1. Cyclin D1 repression of p300 was independent of the Cdk- and retinoblastoma protein-binding domains of cyclin D1. Cyclin D1 inhibits histone acetyltransferase activity of p300 in vitro. Microarray analysis identified a signature of genes repressed by cyclin D1 and induced by p300 that promotes cellular differentiation and induces cell cycle arrest. Together, our results suggest that cyclin D1 plays an important role in cellular proliferation and differentiation through regulation of p300.

Comparison of the quantulus 1220 and 300SL liquid scintillation counters for the analysis of {sup 222}Rn in groundwater

Energy Technology Data Exchange (ETDEWEB)

Kim, Hyun Cheol; Jung, Yoon Hee; Lee, Wanno; Choi, Guen Sik; Chung, Kun Ho; Kang, Mun Ja [Environmental Radioactivity Assessment Team, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-12-15

Liquid scintillation counters (LSCs) are commonly used as an analytical method for detecting {sup 222}Rn in groundwater because they involve a simple sample pretreatment and allow high throughout with an autosampler. The Quantulus 1220 is the best-selling LSC in Korea, but its production was stopped. Recently, a new type of LSC, the 300SL, was introduced. In this study, the 300SL was compared with the Quantulus 1220 in order to evaluate the ability of each apparatus to detect {sup 222}Rn in groundwater. The Quantulus 1220 and 300SL were used to detect the presence of {sup 222}Rn. Radon gas was extracted from a groundwater sample using a water-immiscible cocktail in a LSC vial. The optimal analytical conditions for each LSC were determined using a {sup 222}Rn calibration source prepared with a {sup 226}Ra source. The optimal pulse shape analysis level for alpha and beta separation was 80 for the Quantulus 1220, and the corresponding pulse length index was 12 in the 300SL. The counting efficiency of the Quantulus 1220 for alpha emissions was similar to that of the 300SL, but the background count rate of the Quantulus 1220 was 10 times lower than that of the 300SL. The minimum detectable activity of the Quantulus 1220 was 0.08 Bq·L{sup -,} while that of the 300SL was 0.20 Bq·L{sup -1}. The analytical results regarding {sup 222}Rn in groundwater were less than 10% different between these LSCs. The 300SL is an LSC that is comparable to the Quantulus 1220 for detecting {sup 222}Rn in groundwater. Both LSCs can be applied to determine the levels of {sup 222}Rn in groundwater under the management of the Ministry of Environment.

50 CFR 300.66 - Prohibitions.

Science.gov (United States)

2010-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under 50... while commercial fishing or from sport fishing, as defined at § 300.61, except that persons authorized...

Sample environment for neutron scattering measurements of internal stresses in engineering materials in the temperature range of 6 K to 300 K.

Science.gov (United States)

Kirichek, O; Timms, J D; Kelleher, J F; Down, R B E; Offer, C D; Kabra, S; Zhang, S Y

2017-02-01

Internal stresses in materials have a considerable effect on material properties including strength, fracture toughness, and fatigue resistance. The ENGIN-X beamline is an engineering science facility at ISIS optimized for the measurement of strain and stress using the atomic lattice planes as a strain gauge. Nowadays, the rapidly rising interest in the mechanical properties of engineering materials at low temperatures has been stimulated by the dynamic development of the cryogenic industry and the advanced applications of the superconductor technology. Here we present the design and discuss the test results of a new cryogenic sample environment system for neutron scattering measurements of internal stresses in engineering materials under a load of up to 100 kN and in the temperature range of 6 K to 300 K. Complete cooling of the system starting from the room temperature down to the base temperature takes around 90 min. Understanding of internal stresses in engineering materials at cryogenic temperatures is vital for the modelling and designing of cutting-edge superconducting magnets and other superconductor based applications.

45 CFR 2516.300 - Who may participate in a school-based service-learning program?

Science.gov (United States)

2010-10-01

...-learning program? 2516.300 Section 2516.300 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Eligibility To Participate § 2516.300 Who may participate in a school-based service-learning program? Students...

45 CFR 2517.300 - Who may participate in a community-based service-learning program?

Science.gov (United States)

2010-10-01

...-learning program? 2517.300 Section 2517.300 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE COMMUNITY-BASED SERVICE-LEARNING PROGRAMS Eligibility To Participate § 2517.300 Who may participate in a community-based service-learning program...

Revised ground-water monitoring compliance plan for the 300 area process trenches

Energy Technology Data Exchange (ETDEWEB)

Schalla, R.; Aaberg, R.L.; Bates, D.J.; Carlile, J.V.M.; Freshley, M.D.; Liikala, T.L.; Mitchell, P.J.; Olsen, K.B.; Rieger, J.T.

1988-09-01

This document contains ground-water monitoring plans for process-water disposal trenches located on the Hanford Site. These trenches, designated the 300 Area Process Trenches, have been used since 1973 for disposal of water that contains small quantities of both chemicals and radionuclides. The ground-water monitoring plans contained herein represent revision and expansion of an effort initiated in June 1985. At that time, a facility-specific monitoring program was implemented at the 300 Area Process Trenches as part of a regulatory compliance effort for hazardous chemicals being conducted on the Hanford Site. This monitoring program was based on the ground-water monitoring requirements for interim-status facilities, which are those facilities that do not yet have final permits, but are authorized to continue interim operations while engaged in the permitting process. The applicable monitoring requirements are described in the Resource Conservation and Recovery Act (RCRA), 40 CFR 265.90 of the federal regulations, and in WAC 173-303-400 of Washington State's regulations (Washington State Department of Ecology 1986). The program implemented for the process trenches was designed to be an alternate program, which is required instead of the standard detection program when a facility is known or suspected to have contaminated the ground water in the uppermost aquifer. The plans for the program, contained in a document prepared by the US Department of Energy (USDOE) in 1985, called for monthly sampling of 14 of the 37 existing monitoring wells at the 300 Area plus the installation and sampling of 2 new wells. 27 refs., 25 figs., 15 tabs.

Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia

Directory of Open Access Journals (Sweden)

Yoji Okahara

Full Text Available Objective: We investigated the efficacy of a P300-based brain-computer interface (BCI for patients with spinocerebellar ataxia (SCA, which is often accompanied by cerebellar impairment. Methods: Eight patients with SCA and eight age- and gender-matched healthy controls were instructed to input Japanese hiragana characters using the P300-based BCI with green/blue flicker. All patients depended on some assistance in their daily lives (modified Rankin scale: mean 3.5. The chief symptom was cerebellar ataxia; no cognitive deterioration was present. A region-based, two-step P300-based BCI was used. During the P300 task, eight-channel EEG data were recorded, and a linear discriminant analysis distinguished the target from other nontarget regions of the matrix. Results: The mean online accuracy in BCI operation was 82.9% for patients with SCA and 83.2% for controls; no significant difference was detected. Conclusion: The P300-based BCI was operated successfully not only by healthy controls but also by individuals with SCA. Significance: These results suggest that the P300-based BCI may be applicable for patients with SCA. Keywords: BCI, BMI, P300, Visual stimuli, Spinocerebellar ataxia

40 CFR 300.205 - Planning and coordination structure.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Planning and coordination structure. 300.205 Section 300.205 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.205 Planning and coordination structure. (a...

A P300 event related potential technique for assessment of sexually oriented interest.

Science.gov (United States)

Vardi, Yoram; Volos, Michal; Sprecher, Elliot; Granovsky, Yelena; Gruenwald, Ilan; Yarnitsky, David

2006-12-01

Despite all of the modern, sophisticated tests that exist for diagnosing and assessing male and female sexual disorders, to our knowledge there is no objective psychophysiological test to evaluate sexual arousal and interest. We provide preliminary data showing a decrease in auditory P300 wave amplitude during exposure to sexually explicit video clips and a significant correlation between the auditory P300 amplitude decrease and self-reported scores of sexual arousal and interest in the clips. A total of 30 healthy subjects were exposed to several blocks of auditory stimuli administered using an oddball paradigm. Baseline auditory P300 amplitudes were obtained and auditory stimuli were then delivered while viewing visual clips with 3 types of content, including sport, scenery and sex. Auditory P300 amplitude significantly decreased during viewing clips of all contents. Viewing sexual content clips caused a maximal decrease in P300 amplitude (p <0.0001). In addition, a high correlation was found between the amplitude decrease and scores on the sexual arousal questionnaire regarding the viewed clips (r = 0.61, p <0.001). In addition, the P300 amplitude decrease was significantly related to the sexual interest score (r = 0.37, p = 0.042) but not to interest in clips of nonsexual content. The change in auditory P300 amplitude during exposure to visual stimuli with sexual context seems to be an objective measure of subject sexual interest. This method might be applied to assess therapeutic intervention and as a diagnostic tool for assessing disorders of impaired libido or psychogenic sexual dysfunction.

Site 300 SPCC Plan

Energy Technology Data Exchange (ETDEWEB)

Griffin, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2016-11-23

This Spill Prevention, Control, and Countermeasure (SPCC) Plan describes the measures that are taken at Lawrence Livermore National Laboratory’s (LLNL) Experimental Test Site (Site 300) near Tracy, California, to prevent, control, and handle potential spills from aboveground containers that can contain 55 gallons or more of oil. This SPCC Plan complies with the Oil Pollution Prevention regulation in Title 40 of the Code of Federal Regulations, Part 112 (40 CFR 112) and with 40 CFR 761.65(b) and (c), which regulates the temporary storage of polychlorinated biphenyls (PCBs). This Plan has also been prepared in accordance with Division 20, Chapter 6.67 of the California Health and Safety Code (HSC 6.67) requirements for oil pollution prevention (referred to as the Aboveground Petroleum Storage Act [APSA]), and the United States Department of Energy (DOE) Order No. 436.1. This SPCC Plan establishes procedures, methods, equipment, and other requirements to prevent the discharge of oil into or upon the navigable waters of the United States or adjoining shorelines for aboveground oil storage and use at Site 300. This SPCC Plan has been prepared for the entire Site 300 facility and replaces the three previous plans prepared for Site 300: LLNL SPCC for Electrical Substations Near Buildings 846 and 865 (LLNL 2015), LLNL SPCC for Building 883 (LLNL 2015), and LLNL SPCC for Building 801 (LLNL 2014).

46 CFR 118.300 - Fire pumps.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On a..., the fire pump must be capable of delivering a single hose stream from the highest hydrant, through the...

Changing in Fatigue Life of 300 M Bainitic Steel After Laser Carburizing and Plasma Nitriding

Directory of Open Access Journals (Sweden)

Abdalla Antonio J.

2018-01-01

Full Text Available In this work 300M steel samples is used. This high-strength steel is used in aeronautic and aerospace industry and other structural applications. Initially the 300 M steel sample was submitted to a heat treatment to obtain a bainític structure. It was heated at 850 °C for 30 minutes and after that, cooled at 300 °C for 60 minutes. Afterwards two types of surface treatments have been employed: (a using low-power laser CO2 (125 W for introducing carbon into the surface and (b plasma nitriding at a temperature of 500° C for 3 hours. After surface treatment, the metallographic preparation was carried out and the observations with optical and electronic microscopy have been made. The analysis of the coating showed an increase in the hardness of layer formed on the surface, mainly, among the nitriding layers. The mechanical properties were analyzed using tensile and fatigue tests. The results showed that the mechanical properties in tensile tests were strongly affected by the bainitic microstructure. The steel that received the nitriding surface by plasma treatment showed better fatigue behavior. The results are very promising because the layer formed on steel surface, in addition to improving the fatigue life, still improves protection against corrosion and wear.

Development of a sample environment for neutron diffraction at low temperature

International Nuclear Information System (INIS)

Lee, Jeong Soo; Lee, Chang Hee; Choi, Yong Nam

2000-06-01

This report contains the development of low temperature sample environment for the neutron diffraction and its utilization techniques. With this research, a low temperature experimental facility of T=10-300 K was developed. We measured magnetic peak of La 1 .4Sr 1 .6Mn 2 O 7 due to low temperature phase transition successfully by this unit installed at the sample table of HRPD. Therefore, the research capability for various materials under the low temperature was expanded

UOP HRM 300 Final Exam Guide (New, 2017) NEW

OpenAIRE

ADMIN

2018-01-01

UOP HRM 300 Final Exam Guide (New, 2017) NEW Check this A+ tutorial guideline at http://www.hrm300assignment.com/hrm-300-uop/hrm-300-final-exam-guide-latest For more classes visit http://www.hrm300assignment.com True and False: Please mark either T or F in the appropriate space before the question 1. ____A strategic plan is the company’s plan for how it will match its internal strengths and weaknesses with external opportunities and threats in or...

Cable Design for FAIR SIS 300

NARCIS (Netherlands)

Kaugerts, J.; Moritz, G.; Wilson, M.N.; Ghosh, A.K.; den Ouden, A.

GSI, Darmstadt is preparing to build FAIR (Facility for Antiproton and Ion Research) which include SIS 300, a 300T - m fast-ramping heavy ion synchrotron. Dipoles for this ring will be 2.9 m long, producing 6 T over a 100 mm coil aperture and ramped at 1 T/s. The cable for these dipoles must have

A nuclear desalination complex with a VK-300 boiling type reactor facility

International Nuclear Information System (INIS)

Kuznetzov, Y.N.; Mishanina, Y.A.; Romenkov, A.A.

2004-01-01

RDIPE has developed a detailed design of an enhanced safety nuclear steam supply system (NSSS) with a VK-300 boiling water reactor for combined heat and power generation. The thermal power of the reactor is 750 MW. The maximum electrical power in the condensation mode is 250 MWe. The maximum heat generation capacity of 400 Gcal/h is reached at 150 MWe. This report describes, in brief, the basic technical concepts for the VK-300 NSSS and the power unit, with an emphasis on enhanced safety and good economic performance. With relatively small power, good technical and economic performance of the VK-300 reactor that is a base for the desalination complex is attained through: reduced capital costs of the nuclear plant construction thanks to technical approaches ensuring maximum simplicity of the reactor design and the NSSS layout; a single-circuit power unit configuration (reactor-turbine) excluding expensive equipment with a lot of metal, less pipelines and valves; reduced construction costs of the basic buildings thanks to reduced construction volumes due to rational arrangement concepts; higher reliability of equipment and reduced maintenance and repair costs; longer reactor design service life of up to 60 years; selection of the best reactor and desalination equipment interface pattern. The report considers the potential application of the VK-300 reactor as a source of energy for distillation desalination units. The heat from the reactor is transferred to the desalination unit via an intermediate circuit. Comparison is made between variants of the reactor integration with desalination units of the following types: multi-stage flash (MSF technology); multi-effect distillation horizontal-tube film units of the DOU GTPA type (MED technology). The NDC capacity with the VK-300 reactor, in terms of distillate, will be more than 200,000 m 3 /day, with the simultaneous output of electric power from the turbine generator buses of around 150 MWe. The variants of the

A P300 brain-computer interface based on a modification of the mismatch negativity paradigm.

Science.gov (United States)

Jin, Jing; Sellers, Eric W; Zhou, Sijie; Zhang, Yu; Wang, Xingyu; Cichocki, Andrzej

2015-05-01

The P300-based brain-computer interface (BCI) is an extension of the oddball paradigm, and can facilitate communication for people with severe neuromuscular disorders. It has been shown that, in addition to the P300, other event-related potential (ERP) components have been shown to contribute to successful operation of the P300 BCI. Incorporating these components into the classification algorithm can improve the classification accuracy and information transfer rate (ITR). In this paper, a single character presentation paradigm was compared to a presentation paradigm that is based on the visual mismatch negativity. The mismatch negativity paradigm showed significantly higher classification accuracy and ITRs than a single character presentation paradigm. In addition, the mismatch paradigm elicited larger N200 and N400 components than the single character paradigm. The components elicited by the presentation method were consistent with what would be expected from a mismatch paradigm and a typical P300 was also observed. The results show that increasing the signal-to-noise ratio by increasing the amplitude of ERP components can significantly improve BCI speed and accuracy. The mismatch presentation paradigm may be considered a viable option to the traditional P300 BCI paradigm.

Latência e amplitude do P300 auditivo na doença de Alzheimer: uma revisão sistemática P300 latency and amplitude in Alzheimer's disease: a systematic review

Directory of Open Access Journals (Sweden)

Renata Valle Pedroso

2012-08-01

Full Text Available O P300 desempenha um papel fundamental como método de avaliação e monitoramento das demências, entre elas a doença de Alzheimer. OBJETIVO: Realizar uma busca por artigos que analisaram os valores de latência e amplitude de P300 na doença de Alzheimer. MÉTODOS: Foi realizada uma busca nas seguintes bases de dados: Web of Science, PubMed/Medline, Psyc Info, Biological Abstracts e Scielo. Utilizaram-se as seguintes palavras-chave: speed of information processing, speed of processing, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer, além de referências cruzadas dos artigos selecionados. RESULTADOS: Foram encontrados oito estudos que preencheram os critérios de inclusão adotados para o presente trabalho. Estes estudos mostraram que existe um consenso em relação ao aumento da latência de P300 de idosos com doença de Alzheimer quando comparados com idosos sem a doença. Porém, verifica-se que, com relação à amplitude de P300, ainda não há um consenso, mas, isso pode estar relacionado às diferentes variáveis metodológicas adotadas nos estudos revisados. CONCLUSÃO: Há necessidade de se padronizar as variáveis envolvidas no método de avaliação do P300 para idosos com doença de Alzheimer, para que seja possível comparar os valores de latência e amplitude de P300 dessa população.The P300 plays a key role as a method for monitoring and evaluating dementia, including Alzheimer's disease. OBJECTIVE: The goal of this study was to search for articles which analyzed P300 latency and amplitude values in Alzheimer's disease. METHODS: We searched in the following databases: Web of Science, Pub Med, Psyc Info, Medline, Biological Abstracts and Scielo using the following keywords: speed of information processing, processing speed, information processing, aged, older, elderly, older people, alzheimer dementia, alzheimer disease, Alzheimer and cross-references of selected

300 Junior Novel Anticipation Guides

Science.gov (United States)

Polette, Nancy

2006-01-01

In this book, the author has created reproducible anticipation guides to 300 popular junior novels (grades 4-8) ranging from classics like Ben and Me and Cricket in Times Square to the current award winner, Kira, Kira. The book consists of 300 reproducible sets of open ended values questions to pique the interest of readers. Librarians and…

Síndrome da apneia obstrutiva do sono e o potencial auditivo P300 Obstructive sleep apnea and P300 evoked auditory potential

Directory of Open Access Journals (Sweden)

Carlos Henrique Martins

2011-12-01

Full Text Available A Síndrome da Apneia Obstrutiva do Sono (SAOS diminui as capacidades da atenção, memória e concentração, fatores relacionados com a cognição. A análise dos parâmetros do P300 auditivo permitiria inferir disfunção cognitiva. OBJETIVO: Comparar os dados da polissonografia e do P300 auditivo em adultos, roncopatas primários com portadores de SAOS. CASUÍSTICA E MÉTODO: Estudo prospectivo em roncopatas primários (N=12 e em portadores de SAOS (N=54, submetidos à polissonografia definidos pelo índice de apneia e hipopneia (IAH. As variáveis da polissonografia e as do P300 foram comparadas, pelos testes "T" de Student, exato de Fisher, regressão logística e análise de correlação com nível de significância de 5%. RESULTADOS: O IAH apresentou correlação inversa com a oximetria em ambos os grupos. A prevalência do P300 foi menor no G.SAOS (teste exato de Fisher, p=0,027. A idade dos pacientes não influenciou a prevalência do P300 (análise de regressão; p=0,232. A amplitude do P300 foi menor do G.SAOS (teste "T" de Student; p=0,003 a latência do P300 foi semelhante em ambos os grupos (teste "T" de Student; p=0,89. CONCLUSÃO: A redução da amplitude do P300 nos portadores de SAOS sugere disfunção cognitiva induzida por diminuição da memória auditiva.The obstructive sleep apnea syndrome (OSAS reduces attention span, memory and concentration capacities, all associated with cognition. The analysis of the auditory P300 parameters could help infer cognitive dysfunction. OBJECTIVE: To compare the data from polysomnography and the auditory P300 in adults, primary snorers with OSAS patients. MATERIALS AND METHODS: Prospective study with primary snorers (N=12 and in OSAS patients (N=54, submitted to polysomnography, defined by the apnea-hypopnea index (AHI. The polysomnography and P300 variables were compared by the t-Student test, the Exact Fisher's Test, logistic regression and analysis of correlation with a significance

The Synchrocyclotron (SC) in building 300

CERN Multimedia

Maximilien Brice

2012-01-01

The red magnet of CERN's first accelerator, the Synchrocyclotron (SC), has occupied a large part of Hall 300 since it was installed in the late 1950s. The remaining part of the 300-square-metre building has been used as a storage room since the accelerator was shut down in 1990. Now a public exhibition will breathe new life into the hall.

76 FR 27875 - Airworthiness Directives; Airbus Model A300 and A310 Series Airplanes, and Model A300 B4-600, B4...

Science.gov (United States)

2011-05-13

... Jersey Avenue, SE., Washington, DC. FOR FURTHER INFORMATION CONTACT: Dan Rodina, Aerospace Engineer... the required inspections that will ensure the continued damage tolerance of the affected structure... corroded structure detected during any inspection done in accordance with the Airbus A300 Airworthiness...

34 CFR 300.27 - Limited English proficient.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Limited English proficient. 300.27 Section 300.27... CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.27 Limited English proficient. Limited English proficient has the meaning given the term in section 9101(25) of the ESEA. (Authority: 20...

20 CFR 300.1 - Words and phrases.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Words and phrases. 300.1 Section 300.1 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT DEFINITIONS § 300.1 Words and phrases. For the purposes of the regulations in this part, except where the...

12 CFR 411.300 - Professional and technical services.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Professional and technical services. 411.300 Section 411.300 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING Activities by Other Than Own Employees § 411.300 Professional and technical services. (a) The prohibition on...

34 CFR 300.306 - Determination of eligibility.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Determination of eligibility. 300.306 Section 300.306 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... education and related services, an IEP must be developed for the child in accordance with §§ 300.320 through...

Characterization of a 300-GHz Transmission System for Digital Communications

Science.gov (United States)

Hudlička, Martin; Salhi, Mohammed; Kleine-Ostmann, Thomas; Schrader, Thorsten

2017-08-01

The paper presents the characterization of a 300-GHz transmission system for modern digital communications. The quality of the modulated signal at the output of the system (error vector magnitude, EVM) is measured using a vector signal analyzer. A method using a digital real-time oscilloscope and consecutive mathematical processing in a computer is shown for analysis of signals with bandwidths exceeding that of state-of-the-art vector signal analyzers. The uncertainty of EVM measured using the real-time oscilloscope is open to analysis. Behaviour of the 300-GHz transmission system is studied with respect to various modulation schemes and different signal symbol rates.

FEI Titan 80-300 STEM

Directory of Open Access Journals (Sweden)

Marc Heggen

2016-02-01

Full Text Available The FEI Titan 80-300 STEM is a scanning transmission electron microscope equipped with a field emission electron gun, a three-condenser lens system, a monochromator unit, and a Cs probe corrector (CEOS, a post-column energy filter system (Gatan Tridiem 865 ER as well as a Gatan 2k slow scan CCD system. Characterised by a STEM resolution of 80 pm at 300 kV, the instrument was one of the first of a small number of sub-ångström resolution scanning transmission electron microscopes in the world when commissioned in 2006.

Further case of Rubinstein-Taybi syndrome due to a deletion in EP300.

LENUS (Irish Health Repository)

Foley, Patricia

2012-02-01

Rubinstein-Taybi syndrome (RSTS) is a heterogeneous disorder with approximately 45-55% of patients showing mutations in the CREB binding protein and a further 3% of patients having mutations in EP300. We report a male child with a deletion of exons 3-8 of the EP300 gene who has RSTS. He has a milder skeletal phenotype, a finding that has been described in other cases with EP300 mutations. The mother suffered from pre-eclampsia and HELLP syndrome in the pregnancy. She subsequently developed a mullerian tumor of her cervix 6 years after the birth of her son.

Status of remedial investigation activities in the Hanford Site 300 Area groundwater operable unit

International Nuclear Information System (INIS)

Hulstrom, L.C.; Innis, B.E.; Frank, M.A.

1993-09-01

The Phase 1 remedial investigation (RI) and Phase 1 and 2 feasibility studies (FS) for the 300-FF-5 groundwater operable unit underlying the 300 Area on the Hanford Site have been completed. Analysis and evaluation of soil, sediment, and surface water, and biotic sampling data, groundwater chemistry, and radiological data gathered over the past 3 years has been completed. Risk assessment calculations have been performed. Use of the data gathered, coupled with information from an automated water level data collection system, has enabled engineers to track three plumes that represent the most significant contamination of the groundwater

Optical waveform sampling and error-free demultiplexing of 1.28 Tbit/s serial data in a silicon nanowire

DEFF Research Database (Denmark)

Ji, Hua; Hu, Hao; Galili, Michael

2010-01-01

We experimentally demonstrate 640 Gbit/s and 1.28 Tbit/s serial data optical waveform sampling and 640-to-10 Gbit/s and 1.28 Tbit/s-to-10 Gbit/s error-free demultiplexing using four-wave mixing in a 300nm$$450nm$$5mm silicon nanowire.......We experimentally demonstrate 640 Gbit/s and 1.28 Tbit/s serial data optical waveform sampling and 640-to-10 Gbit/s and 1.28 Tbit/s-to-10 Gbit/s error-free demultiplexing using four-wave mixing in a 300nm$$450nm$$5mm silicon nanowire....

Efforts to Develop a 300°C Solder

Energy Technology Data Exchange (ETDEWEB)

Norann, Randy A [Perma Works LLC

2015-01-25

This paper covers the efforts made to find a 300°C electrical solder solution for geothermal well monitoring and logging tools by Perma Works LLC. This paper covers: why a high temperature solder is needed, what makes for a good solder, testing flux, testing conductive epoxy and testing intermetallic bonds. Future areas of research are suggested.

A key requirement for CD300f in innate immune responses of eosinophils in colitis.

Science.gov (United States)

Moshkovits, I; Reichman, H; Karo-Atar, D; Rozenberg, P; Zigmond, E; Haberman, Y; Ben Baruch-Morgenstern, N; Lampinen, M; Carlson, M; Itan, M; Denson, L A; Varol, C; Munitz, A

2017-01-01

Eosinophils are traditionally studied in the context of type 2 immune responses. However, recent studies highlight key innate immune functions for eosinophils especially in colonic inflammation. Surprisingly, molecular pathways regulating innate immune activities of eosinophil are largely unknown. We have recently shown that the CD300f is highly expressed by colonic eosinophils. Nonetheless, the role of CD300f in governing innate immune eosinophil activities is ill-defined. RNA sequencing of 162 pediatric Crohn's disease patients revealed upregulation of multiple Cd300 family members, which correlated with the presence of severe ulcerations and inflammation. Increased expression of CD300 family receptors was also observed in active ulcerative colitis (UC) and in mice following induction of experimental colitis. Specifically, the expression of CD300f was dynamically regulated in monocytes and eosinophils. Dextran sodium sulfate (DSS)-treated Cd300f -/- mice exhibit attenuated disease activity and histopathology in comparison with DSS-treated wild type (WT). Decreased disease activity in Cd300f -/- mice was accompanied with reduced inflammatory cell infiltration and nearly abolished production of pro-inflammatory cytokines. Monocyte depletion and chimeric bone marrow transfer experiments revealed a cell-specific requirement for CD300f in innate immune activation of eosinophils. Collectively, we uncover a new pathway regulating innate immune activities of eosinophils, a finding with significant implications in eosinophil-associated gastrointestinal diseases.

On-capillary sample cleanup method for the electrophoretic determination of carbohydrates in juice samples.

Science.gov (United States)

Morales-Cid, Gabriel; Simonet, Bartolomé M; Cárdenas, Soledad; Valcárcel, Miguel

2007-05-01

On many occasions, sample treatment is a critical step in electrophoretic analysis. As an alternative to batch procedures, in this work, a new strategy is presented with a view to develop an on-capillary sample cleanup method. This strategy is based on the partial filling of the capillary with carboxylated single-walled carbon nanotube (c-SWNT). The nanoparticles retain interferences from the matrix allowing the determination and quantification of carbohydrates (viz glucose, maltose and fructose). The precision of the method for the analysis of real samples ranged from 5.3 to 6.4%. The proposed method was compared with a method based on a batch filtration of the juice sample through diatomaceous earth and further electrophoretic determination. This method was also validated in this work. The RSD for this other method ranged from 5.1 to 6%. The results obtained by both methods were statistically comparable demonstrating the accuracy of the proposed methods and their effectiveness. Electrophoretic separation of carbohydrates was achieved using 200 mM borate solution as a buffer at pH 9.5 and applying 15 kV. During separation, the capillary temperature was kept constant at 40 degrees C. For the on-capillary cleanup method, a solution containing 50 mg/L of c-SWNTs prepared in 300 mM borate solution at pH 9.5 was introduced for 60 s into the capillary just before sample introduction. For the electrophoretic analysis of samples cleaned in batch with diatomaceous earth, it is also recommended to introduce into the capillary, just before the sample, a 300 mM borate solution as it enhances the sensitivity and electrophoretic resolution.

Survey of Radiological and Chemical Contaminants in the Near-Shore Environment at the Hanford Site 300 Area

International Nuclear Information System (INIS)

Patton, Gregory W.; Van Verst, Scott P.; Tiller, Brett L.; Antonio, Ernest J.; Poston, Ted M.

2003-01-01

This updates the original report by correcting some errors and adding new information. This assessment of the 300 Area was completed to identify any contamination present and determine if it could present a risk to humans and plant and animal life. The assessment characterized the radiological and chemical conditions existing in the near-shore environment of the Columbia River at the 300 Area by collecting water, biota, and sediment samples and measuring radiation levels during a time when the effects of riverbank spring discharges and groundwater upwelling into the river was likely to be present

Site 300 City Water Master Plan

Energy Technology Data Exchange (ETDEWEB)

Shaw, Jeff [Stantec Consulting Services Inc., Irvine, CA (United States)

2017-03-13

Lawrence Livermore National Laboratory (LLNL), a scientific research facility, operates an experimental test site known as Site 300. The site is located in a remote area of southeastern Alameda County, California, and consists of about 100 facilities spread across 7,000-acres. The Site 300 water system includes groundwater wells and a system of storage tanks, booster pumps, and underground piping to distribute water to buildings and significant areas throughout the site. Site 300, which is classified as a non-transient non-community (NTNC) water system, serves approximately 110 employees through 109 service connections. The distribution system includes approximately 76,500-feet of water mains varying from 4- to 10-inches in diameter, mostly asbestos cement (AC) pipe, and eleven water storage tanks. The water system is divided into four pressure zones fed by three booster pump stations to tanks in each zone.

44 CFR 300.3 - Financial assistance.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Financial assistance. 300.3 Section 300.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... responsibilities for IFG, crisis counseling, mass care or other functional responsibilities; (7) Training for State...

34 CFR 300.327 - Educational placements.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Educational placements. 300.327 Section 300.327 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

14 CFR 1251.300 - Discrimination prohibited.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Discrimination prohibited. 1251.300 Section... OF HANDICAP Accessibility § 1251.300 Discrimination prohibited. No qualified handicapped person shall... benefits of, be excluded from participation in, or otherwise be subjected to discrimination under any...

300 K Isothermal Equations of State of DADNE, DNAN, and LX-17

Science.gov (United States)

Zaug, Joseph; Stavrou, Elissaios; Grivickas, Paulius; Pagoria, Phil; Hansen, Donald; Gagliardi, Franco; Sain, John; Bastea, Sorin

2017-06-01

Using a direct optical-based measurement approach, we report 10 GPa scale, 300 K isothermal equations of state (EOS) of single crystal 1,1-Diamino-2,2-dinitroethylene (DADNE, FOX-7), single crystal 2,4, Dintrosoanisole (DNAN) and a polymer blended explosive (PBX) composite LX-17 (92.5% triamino trinitro benzene (TATB), and 7.5% KEL-F 800). Results from quasi-statically compressed LX-17 represent the first-ever isothermal EOS measurements of a PBX. Recently, we published a paper outlining the utility of using in-house optical microscopy and interferometry (OMI) diagnostics to directly measure pressure dependent sample volumes of single crystals TATB and alpha-NTO compressed within diamond-anvil cell sample chambers. (Our TATB OMI results agree remarkably well with two independent powder x-ray diffraction EOS studies.) In addition, here we report single crystal pressure dependent indices of refraction from DADNE that clearly signal the onset of electronic and/or molecular (structural) transitions that are otherwise indistinguishable in 300 K plotted pressure-volume EOS isotherms. EOS model parameters are reported from weighted and unweighted fits to the OMI experimental data. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344.

50 CFR 300.132 - Lobster harvest limitations.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Lobster harvest limitations. 300.132... FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.132 Lobster harvest limitations. (a) Berried lobsters. A berried (egg-bearing) lobster in treaty waters may not be...

46 CFR 403.300 - Financial reporting requirements.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Financial reporting requirements. 403.300 Section 403... UNIFORM ACCOUNTING SYSTEM Reporting Requirements § 403.300 Financial reporting requirements. (a) General: (1) The financial statements shall list each active account, including subsidiary accounts. (2) The...

34 CFR 300.108 - Physical education.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Physical education. 300.108 Section 300.108 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

34 CFR 300.39 - Special education.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Special education. 300.39 Section 300.39 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

7 CFR 3052.300 - Auditee responsibilities.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Auditee responsibilities. 3052.300 Section 3052.300 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER, DEPARTMENT OF AGRICULTURE AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 3052...

Aerial sampling using drones for measuring trace gases

Science.gov (United States)

Chang, Chih-Chung; Wang, Jia-Lin; Chang, Chih-Yuan; Lin, Ming-Ren; Ou-Yang, Chang-Feng; Pan, Xiang-Xu; Lin, Neng-Huei

2017-04-01

Aerial and ground-level samples were simultaneously collected at the northern tip of Taiwan, Cape Fuguei, which is commonly served as a receptor site to receive air parcels from East Asia, Asian continent, the northwest Pacific Ocean and the island of Taiwan itself. Both aerial and surface samples were analyzed for 106 volatile organic compounds (VOCs) and divided into three categories as follows: 1. the total concentrations of 106 VOC (T-VOC) at 300-m height that are lower than the T-VOC level at the surface (Category A), 2. T-VOC concentrations at 300-m that are higher than those at the surface (Category B), and 3. comparable concentrations (Category C). Ten VOCs were exploited as tracers for a variety of emission sources linking to possible sources and transport routes of airborne pollutants. The first two categories A and B showed significant differences in the observed composition and concentrations of tracers between aerial and ground-level samples, implying that the pollutants at different heights may have resulted from different sources and poor air mixing, despite only a 300-m difference in vertical height. In contrast, Category C showed good vertical mixing, as indicated by the comparable concentrations between the aerial and surface measurements. Since the three categories occurred in specific meteorological conditions (between, prior to, and after cold fronts), respectively, it suggests that varied prevailing meteorology controlled the distribution and transport of airborne pollutants. Unlike sampling commonly performed at the surface, this study uses aerial sampling to demonstrate that layered structures under different meteorological conditions. Sampling aloft in lower boundary layer avoids samples being over-influenced by the close-by surface sources such as traffic to reveal signatures of a broader region.

The 300 area waste acid treatment system closure plan

International Nuclear Information System (INIS)

Luke, S.N.

1996-01-01

The 300 Area Waste Acid Treatment System (WATS) is located within operable units 300-FF-2 (source) and 300-FF-5 (groundwater), as designated in the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) . Operable units 300-FF-2 and 300-FF-5 are scheduled to be remediated using the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) Remedial Investigation/Feasibility Study (RI/FS) process. Thus, any remediation of the 300 Area WATS with respect to contaminants not produced by those facilities and soils and groundwater will be deferred to the CERCLA RI/FS process. Final closure activities will be completed in 3 phases and certified in accordance with the 300 Area WATS closure plan by the Washington State Department of Ecology (Ecology) and the U.S. Environmental Protection Agency (EPA). It is anticipated that the 300 Area WATS closure would take 2 years to complete

Initial test of a T9-like P300-based speller by an ALS patient

Science.gov (United States)

Ron-Angevin, R.; Varona-Moya, S.; da Silva-Sauer, L.

2015-08-01

Objective. Visual P300-based brain-computer interface spellers offer a useful communication channel for locked-in patients, who are completely dependent in their daily lives. One of the research goals for these systems is to achieve greater communication rates by means of modifying some features of their interfaces, e.g., reducing the matrix size. However, such modifications may not work well with disabled end-users, such as patients of amyotrophic lateral sclerosis (ALS), due to a supposed reduction of their cognitive resources. The purpose of the present study was to provide a proof of concept that ALS patients could efficiently use a P300-based speller with a 4 × 3 symbol matrix based on the T9 interface developed for mobile phones. Approach. We conducted an experiment with a sample of 11 able-bodied participants and one locked-in patient with ALS. All participants tested our T9-like visual P300-based speller and also two different 7 × 6 matrix spellers based on Farwell and Donchin’s classic proposal—one of them included a word predictor system like the T9-like speller did. Main results. The performance analyses indicated that the locked-in patient benefited from using a reduced matrix size as much as healthy users did, spelling words almost 1.6 times faster and equally accurately when using the T9-like speller than when using the alternative spellers. Significance. Due to counting on only one locked-in patient, the current work constitutes a feasibility study. The actual usability of systems such as the one proposed in this paper should be determined by means of studies with a greater number of end-users in real-life conditions.

14 CFR 1201.300 - Boards and committees.

Science.gov (United States)

2010-01-01

... committees have been established as part of the permanent organization structure of NASA. These include: (a... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Boards and committees. 1201.300 Section 1201.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STATEMENT OF ORGANIZATION...

Use of a Green Familiar Faces Paradigm Improves P300-Speller Brain-Computer Interface Performance.

Science.gov (United States)

Li, Qi; Liu, Shuai; Li, Jian; Bai, Ou

2015-01-01

A recent study showed improved performance of the P300-speller when the flashing row or column was overlaid with translucent pictures of familiar faces (FF spelling paradigm). However, the performance of the P300-speller is not yet satisfactory due to its low classification accuracy and information transfer rate. To investigate whether P300-speller performance is further improved when the chromatic property and the FF spelling paradigm are combined. We proposed a new spelling paradigm in which the flashing row or column is overlaid with translucent green pictures of familiar faces (GFF spelling paradigm). We analyzed the ERP waveforms elicited by the FF and proposed GFF spelling paradigms and compared P300-speller performance between the two paradigms. Significant differences in the amplitudes of four ERP components (N170, VPP, P300, and P600f) were observed between both spelling paradigms. Compared to the FF spelling paradigm, the GFF spelling paradigm elicited ERP waveforms of higher amplitudes and resulted in improved P300-speller performance. Combining the chromatic property (green color) and the FF spelling paradigm led to better classification accuracy and an increased information transfer rate. These findings demonstrate a promising new approach for improving the performance of the P300-speller.

Hazardous waste operational plan for site 300

International Nuclear Information System (INIS)

Roberts, R.S.

1982-01-01

This plan outlines the procedures and operations used at LLNL's Site 300 for the management of the hazardous waste generated. This waste consists primarily of depleted uranium (a by-product of U-235 enrichment), beryllium, small quantities of analytical chemicals, industrial type waste such as solvents, cleaning acids, photographic chemicals, etc., and explosives. This plan details the operations generating this waste, the proper handling of this material and the procedures used to treat or dispose of the hazardous waste. A considerable amount of information found in this plan was extracted from the Site 300 Safety and Operational Manual written by Site 300 Facility personnel and the Hazards Control Department

78 FR 52107 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Rechargeable Lithium...

Science.gov (United States)

2013-08-22

... passengers. The Model 777-200, -300, and -300ER series airplanes have fly-by-wire controls, fully software... lead acid batteries and nickel cadmium batteries. These special conditions provide an equivalent level... characteristics that differ significantly from those of the nickel cadmium and lead acid rechargeable batteries...

34 CFR 300.6 - Assistive technology service.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Assistive technology service. 300.6 Section 300.6 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... selection, acquisition, or use of an assistive technology device. The term includes— (a) The evaluation of...

300 Area Process Trenches Closure Plan

International Nuclear Information System (INIS)

Luke, S.N.

1994-01-01

Since 1987, Westinghouse Hanford Company has been a major contractor to the US Department of Energy, Richland Operations Office and has served as co-operator of the 300 Area Process Trenches, the waste management unit addressed in this closure plan. For the purposes of the Resource Conservation and Recovery Act, Westinghouse Hanford Company is identified as ''co-operator.'' The 300 Area Process Trenches Closure Plan (Revision 0) consists of a Resource Conservation and Recovery Act Part A Dangerous Waste Permit Application, Form 3 and a Resource Conservation and Recovery Act Closure Plan. An explanation of the Part A Permit Application, Form 3 submitted with this document is provided at the beginning of the Part A Section. The closure plan consists of nine chapters and six appendices. The 300 Area Process Trenches received dangerous waste discharges from research and development laboratories in the 300 Area and from fuels fabrication processes. This waste consisted of state-only toxic (WT02), corrosive (D002), chromium (D007), spent halogenated solvents (F001, F002, and F003), and spent nonhalogented solvent (F005). Accurate records are unavailable concerning the amount of dangerous waste discharged to the trenches. The estimated annual quantity of waste (item IV.B) reflects the total quantity of both regulated and nonregulated waste water that was discharged to the unit

17 CFR 300.302 - Mechanics of closeout or completion.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Mechanics of closeout or completion. 300.302 Section 300.302 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Completion of Open Contractual Commitments § 300.302 Mechanics of closeout or completion. (a) The closeout or...

40 CFR 300.220 - Related Title III issues.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Related Title III issues. 300.220 Section 300.220 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY... PLAN Planning and Preparedness § 300.220 Related Title III issues. Other related Title III requirements...

45 CFR 604.300 - Professional and technical services.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Professional and technical services. 604.300 Section 604.300 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NEW RESTRICTIONS ON LOBBYING Activities by Other Than Own Employees § 604.300 Professional and...

Which Iodine concentration in chest CT? - A prospective study in 300 patients

Energy Technology Data Exchange (ETDEWEB)

Muehlenbruch, Georg [RWTH Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Aachen (Germany); University Hospital, RWTH Aachen University, Aachen (Germany); Behrendt, Florian F.; Eddahabi, Mohammed A.; Das, Marco; Guenther, Rolf W.; Mahnken, Andreas H. [RWTH Aachen University Hospital, Department of Diagnostic and Interventional Radiology, Aachen (Germany); Knackstedt, Christian [RWTH Aachen University Hospital, Department of Cardiology, Pulmonology and Angiology, Aachen (Germany); Stanzel, Sven [RWTH Aachen University Hospital, Institute of Medical Statistics, Aachen (Germany); Seidensticker, Peter [Bayer Schering Pharma AG, Berlin (Germany); Wildberger, Joachim E. [University Hospital Maastricht, Department of Radiology, Maastricht (Netherlands)

2008-12-15

In computed tomography(CT) several contrast media with different iodine concentrations are available. The aim of this study is to prospectively compare contrast media with iodine concentrations of 300, 370 and 400 mg iodine/ml for chest- CT. 300 consecutive patients were prospectively enrolled, under a waiver of the local ethics committee. The first (second, third) 100 patients, received contrast medium with 300(370, 400)mg iodine/ml. Injection protocols were adapted for an identical iodine delivery rate(1.3 mg/s) and total iodine load(33 g) for all three groups. Standardized MDCT of the chest (16 x 0.75 mm, 120 kVp, 100 mAseff.) was performed. Intravascular attenuation values were measured in the pulmonary trunk and the ascending aorta; subjective image quality was rated on a 3-point-scale. Discomfort during and after injection was evaluated. There were no statistically significant differences in contrast enhancement comparing the three contrast media at the pulmonary trunk(p = 0.3198) and at the ascending aorta(p = 0.0840). Image quality(p = 0.0176) and discomfort during injection(p = 0.7034) were comparable for all groups. General discomfort after injection of contrast media with 300 mg iodine/ml was statistically significant higher compared to 370 mg iodine/ml(p = 0.00019). Given identical iodine delivery rates of 1.3 g/s and iodine loads of 33 g, contrast media with concentrations of 300, 370 and 400 mg iodine/ml do not result in different intravascular enhancement in chest-CT. (orig.)

Using a Corpus in a 300-Level Spanish Grammar Course

Science.gov (United States)

Benavides, Carlos

2015-01-01

The present study examined the use and effectiveness of a large corpus--the Corpus del Español (Davies, 2002)--in a 300-level Spanish grammar university course. Students conducted hands-on corpus searches with the goal of finding concordances containing particular types of collocations (combinations of words that tend to co-occur) and tokens (any…

Frequency of metabolic syndrome and its components in 300 Pakistani obese patients

International Nuclear Information System (INIS)

Khattak, I.; Ishaq, T.; Fida, Z.; Rehman, F.U.

2017-01-01

To assess the frequency of metabolic syndrome (MS) and its constituents in a sample of Pakistani obese patients. Methodology: In this descriptive and cross-sectional study, we used a sample of 300 patients from Khyber Teaching Hospital, Peshawar, Pakistan from April 2016 to November 2016. They were randomly selected and their mean age was between 15 and 25 years. The variables obtained included BMI, both systolic and diastolic blood pressure, cholesterol, fasting blood glucose, triglyceride levels, LDL- cholesterol, HDL-cholesterol, waist to hip ratio, waist circumference and insulin resistance. Results: Of the 300 patients, the frequency of MS was 20%. There were no significant differences in the frequency of developing MS between the genders. The order of frequency of the components as observed was as follows; abdominal obesity was 88%, high triglyceride level was 85%, males were 40%, 40% of the sampled population resided in the urban area. Meanwhile, 35% of the patients had hypertension while only 5% had hyperglycemia. The frequency of developing MS was 70 times higher in patients with high triglyceride levels in their when compared to those with normal levels. Conclusion: The frequency of MS and its components in Pakistani adolescent patients is high. The high levels of triglyceride and a sedentary lifestyle profoundly contributed to MS. Moreover, the findings signify the importance of early treatment and prevention of obesity in working toward reducing the rate of diabetes mellitus type 2; as glucose intolerance had a strong relationship with the components of MS, and cardiovascular diseases such coronary artery disease. (author)

Potencial evocado auditivo tardio relacionado a eventos (P300 na síndrome de Down Late auditory event-related evoked potential (P300 in Down's syndrome patients

Directory of Open Access Journals (Sweden)

Carla Patrícia Hernandez Alves Ribeiro César

2010-04-01

Full Text Available A síndrome de Down é causada pela trissomia do cromossomo 21 e está associada com alteração do processamento auditivo, distúrbio de aprendizagem e, provavelmente, início precoce de Doença de Alzheimer. OBJETIVO: Avaliar as latências e amplitudes do potencial evocado auditivo tardio relacionado a eventos (P300 e suas alterações em indivíduos jovens adultos com síndrome de Down. MATERIAL E MÉTODO: Estudo de caso prospectivo. Latências e amplitudes do P300 foram avaliadas em 17 indivíduos com síndrome de Down e 34 indivíduos sadios. RESULTADOS: Foram identificadas latências do P300 (N1, P2, N2 e P3 prolongadas e amplitude N2 - P3 diminuída nos indivíduos com síndrome de Down quando comparados ao grupo controle. CONCLUSÃO: Em indivíduos jovens adultos com síndrome de Down ocorre aumento das latências N1, P2, N2 e P3, e diminuição significativa da amplitude N2-P3 do potencial evocado auditivo tardio relacionado a eventos (P300, sugerindo prejuízo da integração da área de associação auditiva com as áreas corticais e subcorticais do sistema nervoso central.Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. AIM: to evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. MATERIALS AND METHODS: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3 was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. CONCLUSION: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced

Perceptions of Rape and Attitudes toward Women in a Sample of Lebanese Students

Science.gov (United States)

Rebeiz, Maria J.; Harb, Charles

2010-01-01

This study investigated values, ambivalent sexism, religiosity, religious differences, gender, and attitudes toward rape victims as predictors of rape myths in a sample of Lebanese students (N = 300). Values of self-transcendence and conservation, gender, hostile sexism, and attitudes toward rape victims emerged as significant predictors of rape…

Comparative Study Using 100–300 Versus 300–500 μm Microspheres for Symptomatic Patients Due to Enlarged-BPH Prostates

International Nuclear Information System (INIS)

Gonçalves, Octavio Meneghelli; Carnevale, Francisco Cesar; Moreira, Airton Mota; Antunes, Alberto Azoubel; Rodrigues, Vanessa Cristina; Srougi, Miguel

2016-01-01

PurposeThe purpose of the study was to compare safety and efficacy outcomes following prostate artery embolization (PAE) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 100–300 versus 300–500 μm tris-acryl gelatin microspheres.Materials and MethodsPatients were prospectively treated between August 2011 and June 2013 to receive PAE with 100–300 μm (group A) or 300–500 μm (group B) tris-acryl gelatin microspheres. Patients were followed for a minimum of 12 months and were assessed for changes in International Prostate Symptom Score (IPSS), quality of life (QoL) index, prostate volume determined by magnetic resonance imaging, serum prostate specific antigen (PSA), and maximum urine flow rate (Q_m_a_x), as well as any treatment-related adverse events.ResultsFifteen patients were included in each group, and PAE was technically successful in all cases. Both groups experienced significant improvement in mean IPSS, QoL, prostate volume, PSA, and Q_m_a_x (p < 0.05 for all). The differences observed between the two groups included a marginally insignificant more adverse events (p = 0.066) and greater mean serum PSA reduction at 3 months of follow-up (p = 0.056) in group A.ConclusionsBoth 100–300 and 300–500 μm microspheres are safe and effective embolic agents for PAE to treat LUTS-related to BPH. Although functional and imaging outcomes did not differ significantly following use of the two embolic sizes, the greater incidence of adverse events with 100–300 μm microspheres suggests that 300–500 μm embolic materials may be more appropriate.

P300 brain computer interface: current challenges and emerging trends

Science.gov (United States)

Fazel-Rezai, Reza; Allison, Brendan Z.; Guger, Christoph; Sellers, Eric W.; Kleih, Sonja C.; Kübler, Andrea

2012-01-01

A brain-computer interface (BCI) enables communication without movement based on brain signals measured with electroencephalography (EEG). BCIs usually rely on one of three types of signals: the P300 and other components of the event-related potential (ERP), steady state visual evoked potential (SSVEP), or event related desynchronization (ERD). Although P300 BCIs were introduced over twenty years ago, the past few years have seen a strong increase in P300 BCI research. This closed-loop BCI approach relies on the P300 and other components of the ERP, based on an oddball paradigm presented to the subject. In this paper, we overview the current status of P300 BCI technology, and then discuss new directions: paradigms for eliciting P300s; signal processing methods; applications; and hybrid BCIs. We conclude that P300 BCIs are quite promising, as several emerging directions have not yet been fully explored and could lead to improvements in bit rate, reliability, usability, and flexibility. PMID:22822397

Blood gas sample spiking with total parenteral nutrition, lipid emulsion, and concentrated dextrose solutions as a model for predicting sample contamination based on glucose result.

Science.gov (United States)

Jara-Aguirre, Jose C; Smeets, Steven W; Wockenfus, Amy M; Karon, Brad S

2018-05-01

Evaluate the effects of blood gas sample contamination with total parenteral nutrition (TPN)/lipid emulsion and dextrose 50% (D50) solutions on blood gas and electrolyte measurement; and determine whether glucose concentration can predict blood gas sample contamination with TPN/lipid emulsion or D50. Residual lithium heparin arterial blood gas samples were spiked with TPN/lipid emulsion (0 to 15%) and D50 solutions (0 to 2.5%). Blood gas (pH, pCO2, pO2), electrolytes (Na+, K+ ionized calcium) and hemoglobin were measured with a Radiometer ABL90. Glucose concentration was measured in separated plasma by Roche Cobas c501. Chart review of neonatal blood gas results with glucose >300 mg/dL (>16.65 mmol/L) over a seven month period was performed to determine whether repeat (within 4 h) blood gas results suggested pre-analytical errors in blood gas results. Results were used to determine whether a glucose threshold could predict contamination resulting in blood gas and electrolyte results with greater than laboratory-defined allowable error. Samples spiked with 5% or more TPN/lipid emulsion solution or 1% D50 showed glucose concentration >500 mg/dL (>27.75 mmol/L) and produced blood gas (pH, pO 2 , pCO 2 ) results with greater than laboratory-defined allowable error. TPN/lipid emulsion, but not D50, produced greater than allowable error in electrolyte (Na + ,K + ,Ca ++ ,Hb) results at these concentrations. Based on chart review of 144 neonatal blood gas results with glucose >250 mg/dL received over seven months, four of ten neonatal intensive care unit (NICU) patients with glucose results >500 mg/dL and repeat blood gas results within 4 h had results highly suggestive of pre-analytical error. Only 3 of 36 NICU patients with glucose results 300-500 mg/dL and repeat blood gas results within 4 h had clear pre-analytical errors in blood gas results. Glucose concentration can be used as an indicator of significant blood sample contamination with either TPN

Mitigation action plan for 300-FF-1 remedial action

International Nuclear Information System (INIS)

Weiss, S.G.

1996-10-01

A record of decision was issued (dated July 1996), for remediation of waste sites in the 300-FF-1 Operable Unit in the 300 Area of the Hanford Site. The selected remedies for the 300-FF-1 and 300-FF-5 waste sites include selective excavation and disposal of contaminated soil and debris from the process waste units, excavation and removal of the 618-4 Burial Ground, and institutional controls for groundwater. This mitigation action plan explains how cultural resources will be managed and how revegetation for these remedial activities will be planned

Object Extraction in Cluttered Environments via a P300-Based IFCE

Directory of Open Access Journals (Sweden)

Xiaoqian Mao

2017-01-01

Full Text Available One of the fundamental issues for robot navigation is to extract an object of interest from an image. The biggest challenges for extracting objects of interest are how to use a machine to model the objects in which a human is interested and extract them quickly and reliably under varying illumination conditions. This article develops a novel method for segmenting an object of interest in a cluttered environment by combining a P300-based brain computer interface (BCI and an improved fuzzy color extractor (IFCE. The induced P300 potential identifies the corresponding region of interest and obtains the target of interest for the IFCE. The classification results not only represent the human mind but also deliver the associated seed pixel and fuzzy parameters to extract the specific objects in which the human is interested. Then, the IFCE is used to extract the corresponding objects. The results show that the IFCE delivers better performance than the BP network or the traditional FCE. The use of a P300-based IFCE provides a reliable solution for assisting a computer in identifying an object of interest within images taken under varying illumination intensities.

Comparative Study Using 100–300 Versus 300–500 μm Microspheres for Symptomatic Patients Due to Enlarged-BPH Prostates

Energy Technology Data Exchange (ETDEWEB)

Gonçalves, Octavio Meneghelli, E-mail: octaviogalvao@hotmail.com; Carnevale, Francisco Cesar, E-mail: francisco.carnevale@criep.com.br; Moreira, Airton Mota, E-mail: motamoreira@gmail.com [University of Sao Paulo Medical School, Interventional Radiology Unit (Brazil); Antunes, Alberto Azoubel, E-mail: antunesuro@uol.com.br [University of Sao Paulo Medical School, Division of Urology (Brazil); Rodrigues, Vanessa Cristina, E-mail: vanessapaular@yahoo.com.br [University of Sao Paulo Medical School, Interventional Radiology Unit (Brazil); Srougi, Miguel, E-mail: srougi@terra.com.br [University of Sao Paulo Medical School, Division of Urology (Brazil)

2016-10-15

PurposeThe purpose of the study was to compare safety and efficacy outcomes following prostate artery embolization (PAE) for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) with 100–300 versus 300–500 μm tris-acryl gelatin microspheres.Materials and MethodsPatients were prospectively treated between August 2011 and June 2013 to receive PAE with 100–300 μm (group A) or 300–500 μm (group B) tris-acryl gelatin microspheres. Patients were followed for a minimum of 12 months and were assessed for changes in International Prostate Symptom Score (IPSS), quality of life (QoL) index, prostate volume determined by magnetic resonance imaging, serum prostate specific antigen (PSA), and maximum urine flow rate (Q{sub max}), as well as any treatment-related adverse events.ResultsFifteen patients were included in each group, and PAE was technically successful in all cases. Both groups experienced significant improvement in mean IPSS, QoL, prostate volume, PSA, and Q{sub max} (p < 0.05 for all). The differences observed between the two groups included a marginally insignificant more adverse events (p = 0.066) and greater mean serum PSA reduction at 3 months of follow-up (p = 0.056) in group A.ConclusionsBoth 100–300 and 300–500 μm microspheres are safe and effective embolic agents for PAE to treat LUTS-related to BPH. Although functional and imaging outcomes did not differ significantly following use of the two embolic sizes, the greater incidence of adverse events with 100–300 μm microspheres suggests that 300–500 μm embolic materials may be more appropriate.

Compilation of historical information of 300 Area facilities and activities

International Nuclear Information System (INIS)

Gerber, M.S.

1992-12-01

This document is a compilation of historical information of the 300 Area activities and facilities since the beginning. The 300 Area is shown as it looked in 1945, and also a more recent (1985) look at the 300 Area is provided

Compilation of historical information of 300 Area facilities and activities

Energy Technology Data Exchange (ETDEWEB)

Gerber, M.S.

1992-12-01

This document is a compilation of historical information of the 300 Area activities and facilities since the beginning. The 300 Area is shown as it looked in 1945, and also a more recent (1985) look at the 300 Area is provided.

[Normative aspects of somatosensory evoked P300 components].

Science.gov (United States)

Louzã Neto, M R; Maurer, K; Neuhauser, B

1989-06-01

Using a somatosensory version of the oddball-paradigma the influence of age and gender on the P300-component and the comparison of the potential after stimulation of the right and left median nerve was studied in 30 healthy right handed volunteers (age: 20-35 years). Latency, amplitude, area and duration of the P300-potential were analysed. No relationship between age, gender and the P300-parameters were observed. The amplitude and the area of the potential obtained from the F3 electrode were greater after stimulation of the right median nerve compared to the potential after stimulation of the left median nerve. All other results were not significantly different. Strong positive correlations between the results after stimulation of the right and left median nerve were observed. These results showed that by a young group of volunteers age and gender did not influence the P300-component. Although the P300-Parameters had a between-subject variability, their mean remained constant over the study, their correlation coefficients were strong positive and the side of stimulation did not influence them (except for the electrode F3).

Stability of a formulation of zidovudine 300 mg tablets

International Nuclear Information System (INIS)

Ibannez Calvo, Sergio; Garcia Penna, Caridad Margarita; Leon Rodriguez, Rafael

2010-01-01

Authors developed a validation of analytical method by high-performance liquid applicable to stability study of Zidovudine (300 mg tablets). The validated analytical method was linear, specific and exact. Above mentioned study was developed determing its expiry date. This study was conducted by fixed life and of accelerated stability methods by high-performance liquid chromatography, validated in Drugs Research and Development Center (Havana, Cuba). Fixed life study was conducted during 24 months at room temperature whereas the accelerated stability study was conducted exposing the product to light influence and humidity during three months and to temperature during 6 months. Zidovudine formula (300 mg tablets) fulfilled the quality specifications described in Pharmacopeia. After 24 months results of stability study by fixed life showed that product maintained the parameters determining its quality during that period and in accelerated studies there was not a significant degradation of product. Two years was established as expiry date in above mentioned conditions

Rudimentary Cleaning Compared to Level 300A

Science.gov (United States)

Arpin, Christina Y. Pina; Stoltzfus, Joel

2012-01-01

A study was done to characterize the cleanliness level achievable when using a rudimentary cleaning process, and results were compared to JPR 5322.1G Level 300A. While it is not ideal to clean in a shop environment, some situations (e.g., field combat operations) require oxygen system hardware to be maintained and cleaned to prevent a fire hazard, even though it cannot be sent back to a precision cleaning facility. This study measured the effectiveness of basic shop cleaning. Initially, three items representing parts of an oxygen system were contaminated: a metal plate, valve body, and metal oxygen bottle. The contaminants chosen were those most likely to be introduced to the system during normal use: oil, lubricant, metal shavings/powder, sand, fingerprints, tape, lip balm, and hand lotion. The cleaning process used hot water, soap, various brushes, gaseous nitrogen, water nozzle, plastic trays, scouring pads, and a controlled shop environment. Test subjects were classified into three groups: technical professionals having an appreciation for oxygen hazards; professional precision cleaners; and a group with no previous professional knowledge of oxygen or precision cleaning. Three test subjects were in each group, and each was provided with standard cleaning equipment, a cleaning procedure, and one of each of the three test items to clean. The results indicated that the achievable cleanliness level was independent of the technical knowledge or proficiency of the personnel cleaning the items. Results also showed that achieving a Level 300 particle count was more difficult than achieving a Level A nonvolatile residue amount.

Design and development of gas turbine high temperature reactor 300 (GTHTR300)

International Nuclear Information System (INIS)

Kunitomi, Kazuhiko; Katanishi, Shoji; Takada, Shoji; Takizuka, Takakazu; Yan, Xing; Kosugiyama, Shinichi

2003-01-01

JAERI (Japan Atomic Energy Research Institute) started design and development of the high temperature gas cooled reactor with a gas turbine electric generation system, GTHTR300, in April 2001. Design originalities of the GTHTR300 are a horizontally mounted highly efficient gas turbine system and an ultimately simplified safety system such as no containment building and no active emergency core cooling. These design originalities are proposed based on design and operational experiences in conventional gas turbine systems and Japan's first high temperature gas cooled reactor (HTTR: High Temperature Engineering Test Reactor) so that many R and Ds are not required for the development. Except these original design features, devised core design, fuel design and plant design are adopted to meet design requirements and attain a target cost. This paper describes the unique design features focusing on the safety design, reactor core design and gas turbine system design together with a preliminary result of the safety evaluation carried out for a typical severe event. This study is entrusted from Ministry of Education, Culture, Sports, Science and Technology of Japan. (author)

5 CFR 300.405 - Requirement for contract.

Science.gov (United States)

2010-01-01

... principles and equal opportunity laws. ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Requirement for contract. 300.405 Section... (GENERAL) Use of Commercial Recruiting Firms and Nonprofit Employment Services § 300.405 Requirement for...

Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300.

Science.gov (United States)

Wang, Chong; Zhou, Hufeng; Xue, Yong; Liang, Jun; Narita, Yohei; Gerdt, Catherine; Zheng, Amy Y; Jiang, Runsheng; Trudeau, Stephen; Peng, Chih-Wen; Gewurz, Benjamin E; Zhao, Bo

2018-05-01

Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP is essential for EBV-mediated B-cell immortalization. EBNALP is thought to function primarily by coactivating EBNA2-mediated transcription. Chromatin immune precipitation followed by deep sequencing (ChIP-seq) studies highlight that EBNALP frequently cooccupies DNA sites with host cell transcription factors (TFs), in particular, EP300, implicating a broader role in transcription regulation. In this study, we investigated the mechanisms of EBNALP transcription coactivation through EP300. EBNALP greatly enhanced EP300 transcription activation when EP300 was tethered to a promoter. EBNALP coimmunoprecipitated endogenous EP300 from lymphoblastoid cell lines (LCLs). EBNALP W repeat serine residues 34, 36, and 63 were required for EP300 association and coactivation. Deletion of the EP300 histone acetyltransferase (HAT) domain greatly reduced EBNALP coactivation and abolished the EBNALP association. An EP300 bromodomain inhibitor also abolished EBNALP coactivation and blocked the EP300 association with EBNALP. EBNALP sites cooccupied by EP300 had significantly higher ChIP-seq signals for sequence-specific TFs, including SPI1, RelA, EBF1, IRF4, BATF, and PAX5. EBNALP- and EP300-cooccurring sites also had much higher H3K4me1 and H3K27ac signals, indicative of activated enhancers. EBNALP-only sites had much higher signals for DNA looping factors, including CTCF and RAD21. EBNALP coactivated reporters under the control of NF-κB or SPI1. EP300 inhibition abolished EBNALP coactivation of these reporters. Clustered regularly interspaced short palindromic repeat interference targeting of EBNALP enhancer sites significantly reduced target gene expression, including that of EP300 itself. These data suggest a previously unrecognized mechanism by which EBNALP coactivates transcription through subverting of EP300 and thus affects the expression of

Auditory evoked potential P300 in adults: reference values.

Science.gov (United States)

Didoné, Dayane Domeneghini; Garcia, Michele Vargas; Oppitz, Sheila Jacques; Silva, Thalisson Francisco Finamôr da; Santos, Sinéia Neujahr Dos; Bruno, Rúbia Soares; Filha, Valdete Alves Valentins Dos Santos; Cóser, Pedro Luis

2016-01-01

To establish reference intervals for cognitive potential P300 latency using tone burst stimuli. This study involved 28 participants aged between 18 and 59 years. P300 recordings were performed using a two-channel device (Masbe, Contronic). Electrode placement was as follows: Fpz (ground electrode), Cz (active electrode), M1 and M2 (reference electrodes). Intensity corresponded to 80 dB HL and frequent and rare stimulus frequencies to 1,000Hz and 2,000Hz, respectively. Stimuli were delivered binaurally. Mean age of participants was 35 years. Average P300 latency was 305ms. Maximum acceptable P300 latency values of 362.5ms (305 + 2SD 28.75) were determined for adults aged 18 to 59 years using the protocol described. Estabelecer valores de referência para a latência do potencial cognitivo P300 com estímulos tone burst. Participaram do estudo 28 indivíduos entre 18 e 59 anos. O registro do P300 foi realizado no equipamento Masbe da marca Contronic. Os eletrodos foram fixados nas posições Fpz (eletrodo terra), Cz (eletrodo ativo), M1 e M2 (eletrodos referência). A intensidade foi de 80 dB NA. A frequência do estímulo frequente foi de 1.000Hz e a do estímulo raro de 2.000Hz. Os estímulos foram apresentados na forma binaural. A média de idade dos indivíduos foi de 35 anos. A média de latência para P300 de 305ms. Usando o protocolo descrito, o valor máximo de latência aceitáveis para P300 foram de 362,5ms (305 + 2DP 28,75) na faixa etária do adulto de 18 a 59 anos.

Avaliação pelo P300 de crianças com e sem epilepsia e rendimento escolar Assessment through P300 of epileptic and non-epileptic children and school performance

Directory of Open Access Journals (Sweden)

JUCELEI F. VISIOLI-MELO

2000-06-01

Full Text Available Dificuldade de aprendizagem é situação comum em crianças com epilepsia. Distúrbios da inteligência têm sido associados com epilepsia. O potencial cognitivo (P300 é um adjunto clínico para mensurar neurofisiologicamente o processo cognitivo. Foram estudadas 99 crianças com 10 anos a 11 anos e 11 meses. Do Grupo I, sem epilepsia, faziam parte 64 crianças, das quais 32 com bom rendimento e outras 32 com mau rendimento escolar. Do Grupo II, com epilepsia, faziam parte 35 crianças, sendo 21 com bom rendimento escolar e 15 com mau rendimento escolar. Não foi encontrada diferença significativa na latência do P300 entre os dois grupos. Quando foram estratificados segundo o desempenho escolar, as crianças do Grupo I, com bom rendimento escolar, apresentaram latência do P300 de 336 ms e as com mau rendimento escolar, latência de 382 ms; as crianças do Grupo II, com bom rendimento escolar, apresentaram latência do P300 de 363 ms e as com mau rendimento escolar, latência de 400 ms, com diferença significativa. Essa diferença estava localizada entre as crianças não epilépticas com bom desempenho escolar e as com mau desempenho escolar, epilépticas ou não.Learning disability is common in epileptic children. Epilepsy has been associated with disorders of intelligence. Cognitive potential (P300 is considered to be a clinical aid in the neurophysiological measurement of the cognitive process. Ninety-nine children between the ages of 10 years and 11 years and 11 months formed our sample, with good and poor school performance. Group I, non-epileptic, had 64 children of whom 32 had good and 32 poor school performance. Group II, epileptic, had 35 children, of whom 21 had good and 15 poor school performance. No significant difference in P300 latency was found between Groups I and II. When groups were stratified based on school performance, Group I children with good school performance had P300 latency of 336 ms, while the ones with poor

PNG-300 a nanosecond pulsed neutron generator

International Nuclear Information System (INIS)

Sztaricskai, T.; Vasvary, L.; Petoe, G.C.; Devkin, B.V.

1985-01-01

The design and operation of a nanosecond-pulse neutron generator is reported. It was constructed for the measurement of prompt neutron and gamma radiation in experimental studies of fast neutron reactions by time of flight techniques. The acceleration voltage is 300 kV and the total resolution of the generator-neutron spectrometer system is 2 ns. The ion-optical system, the vacuum system and the control of the neutron generator is described in detail. The equipment was used for prompt neutron and gamma radiation induced in construction materials. (R.P.)

45 CFR 1230.300 - Professional and technical services.

Science.gov (United States)

2010-10-01

... technical discipline. For example, drafting or a legal document accompanying a bid or proposal by a lawyer... 45 Public Welfare 4 2010-10-01 2010-10-01 false Professional and technical services. 1230.300....300 Professional and technical services. (a) The prohibition on the use of appropriated funds, in...

7 CFR 3018.300 - Professional and technical services.

Science.gov (United States)

2010-01-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 7 Agriculture 15 2010-01-01 2010-01-01 false Professional and technical services. 3018.300 Section... Employees § 3018.300 Professional and technical services. (a) The prohibition on the use of appropriated...

49 CFR 20.300 - Professional and technical services.

Science.gov (United States)

2010-10-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 49 Transportation 1 2010-10-01 2010-10-01 false Professional and technical services. 20.300... Activities by Other Than Own Employees § 20.300 Professional and technical services. (a) The prohibition on...

Development of k-300 concrete mix for earthquake-resistant Housing infrastructure in indonesia

Science.gov (United States)

Zulkarnain, Fahrizal

2018-03-01

In determining the strength of K-300 concrete mix that is suitable for earthquake-resistant housing infrastructure, it is necessary to research the materials to be used for proper quality and quantity so that the mixture can be directly applied to the resident’s housing, in the quake zone. In the first stage, the examination/sieve analysis of the fine aggregate or sand, and the sieve analysis of the coarse aggregate or gravel will be carried out on the provided sample weighing approximately 40 kilograms. Furthermore, the specific gravity and absorbance of aggregates, the examination of the sludge content of aggregates passing the sieve no. 200, and finally, examination of the weight of the aggregate content. In the second stage, the planned concrete mix by means of the Mix Design K-300 is suitable for use in Indonesia, with implementation steps: Planning of the cement water factor (CWF), Planning of concrete free water (Liters / m3), Planning of cement quantity, Planning of minimum cement content, Planning of adjusted cement water factor, Planning of estimated aggregate composition, Planning of estimated weight of concrete content, Calculation of composition of concrete mixture, Calculation of mixed correction for various water content. Implementation of the above tests also estimates the correction of moisture content and the need for materials of mixture in kilograms for the K-300 mixture, so that the slump inspection result will be achieved in planned 8-12 cm. In the final stage, a compressive strength test of the K-300 experimental mixture is carried out, and subsequently the composition of the K-300 concrete mixture suitable for one sack of cement of 50 kg is obtained for the foundation of the proper dwelling. The composition is consists of use of Cement, Sand, Gravel, and Water.

38 CFR 45.300 - Professional and technical services.

Science.gov (United States)

2010-07-01

... technical discipline. For example, drafting or a legal document accompanying a bid or proposal by a lawyer... technical services. 45.300 Section 45.300 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS... Professional and technical services. (a) The prohibition on the use of appropriated funds, in § 45.100(a), does...

10 CFR 300.4 - Selecting organizational boundaries.

Science.gov (United States)

2010-01-01

... determining their organizational boundaries, with financial control meaning the ability to direct the... control. (2) Entities may establish organizational boundaries using approaches other than financial... 10 Energy 3 2010-01-01 2010-01-01 false Selecting organizational boundaries. 300.4 Section 300.4...

Subproject L-045H 300 Area Treated Effluent Disposal Facility

International Nuclear Information System (INIS)

1991-06-01

The study focuses on the project schedule for Project L-045H, 300 Area Treated Effluent Disposal Facility. The 300 Area Treated Effluent Disposal Facility is a Department of Energy subproject of the Hanford Environmental Compliance Project. The study scope is limited to validation of the project schedule only. The primary purpose of the study is to find ways and means to accelerate the completion of the project, thereby hastening environmental compliance of the 300 Area of the Hanford site. The ''300 Area'' has been utilized extensively as a laboratory area, with a diverse array of laboratory facilities installed and operational. The 300 Area Process Sewer, located in the 300 Area on the Hanford Site, collects waste water from approximately 62 sources. This waste water is discharged into two 1500 feet long percolation trenches. Current environmental statutes and policies dictate that this practice be discontinued at the earliest possible date in favor of treatment and disposal practices that satisfy applicable regulations

Novel ZIF-300 Mixed-Matrix Membranes for Efficient CO2 Capture.

Science.gov (United States)

Yuan, Jianwei; Zhu, Haipeng; Sun, Jiajia; Mao, Yangyang; Liu, Gongping; Jin, Wanqin

2017-11-08

Because of the high separation performance and easy preparation, mixed-matrix membranes (MMMs) consisting of metal-organic frameworks have received much attention. In this article, we report a novel ZIF-300/PEBA MMM consisting of zeolite imidazolate framework (ZIF-300) crystals and polyether block amide (PEBA) matrix. The ZIF-300 crystal size was effectively reduced by optimizing the hydrothermal reaction condition from ∼15 to ∼1 μm. The morphology and physicochemical and sorption properties of the synthesized ZIF-300 crystals and as-prepared ZIF-300/PEBA MMMs were systematically studied. The results showed that ZIF-300 crystals with a size of ∼1 μm maintained excellent preferential CO 2 sorption over N 2 without degradation of the crystal structure in the MMMs. As a result, uniformly incorporated ZIF-300 crystals highly enhanced both the CO 2 permeability and the CO 2 /N 2 selectivity of pure PEBA membrane. The optimized ZIF-300-PEBA MMMs with a ZIF-300 loading of 30 wt % exhibited a high and stable CO 2 permeability of 83 Barrer and CO 2 /N 2 selectivity of 84, which are 59.2% and 53.5% higher than pure PEBA membrane, respectively. The obtained performance surpassed the upper bound of state-of-the-art membranes for CO 2 /N 2 separation. This work demonstrated that the proposed ZIF-300/PEBA MMM could be a potential candidate for an efficient CO 2 capture process.

21 CFR 522.1660b - Oxytetracycline solution, 300 milligrams/milliliter.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Oxytetracycline solution, 300 milligrams... FORM NEW ANIMAL DRUGS § 522.1660b Oxytetracycline solution, 300 milligrams/milliliter. (a) Specifications. Each milliliter (mL) of solution contains 300 milligrams (mg) oxytetracycline base. (b) Sponsor...

Thermal Stability of Austempered Ductile Iron Evaluated in a Temperature Range of 20-300K

Directory of Open Access Journals (Sweden)

Dawid MYSZKA

2016-05-01

Full Text Available The aim of this article was to determine through changes in magnetic properties the stability of the austempered ductile iron (ADI microstructure during temperature changes in a range of 20 – 300 K. The measurements were taken in a vibrating sample magnetometer (VSM using Fe27Ni2TiMoAlNb austenitic stainless steel and four types of austempered ductile iron obtained under various heat treatment conditions. The plotted curves showing changes in the magnetisation degree as a function of temperature had a number of characteristic points illustrating changes taking place in the microstructure. For each of the materials examined, the martensite start temperature Ms and the temperature range within which the martensitic transformation takes place were identified.

45 CFR 1158.300 - Professional and technical services.

Science.gov (United States)

2010-10-01

... analysis directly applying any professional or technical discipline. For example, drafting or a legal... 45 Public Welfare 3 2010-10-01 2010-10-01 false Professional and technical services. 1158.300... Other Than Own Employees § 1158.300 Professional and technical services. (a) The prohibition on the use...

10 CFR 601.300 - Professional and technical services.

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2010-01-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 10 Energy 4 2010-01-01 2010-01-01 false Professional and technical services. 601.300 Section 601... Activities by Other Than Own Employees § 601.300 Professional and technical services. (a) The prohibition on...

45 CFR 1168.300 - Professional and technical services.

Science.gov (United States)

2010-10-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 45 Public Welfare 3 2010-10-01 2010-10-01 false Professional and technical services. 1168.300... Activities by Other Than Own Employees § 1168.300 Professional and technical services. (a) The prohibition on...

22 CFR 138.300 - Professional and technical services.

Science.gov (United States)

2010-04-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 138.300... Activities by Other Than Own Employees § 138.300 Professional and technical services. (a) The prohibition on...

22 CFR 519.300 - Professional and technical services.

Science.gov (United States)

2010-04-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Professional and technical services. 519.300... by Other Than Own Employees § 519.300 Professional and technical services. (a) The prohibition on the...

22 CFR 227.300 - Professional and technical services.

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2010-04-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Professional and technical services. 227.300... Activities by Other Than Own Employees § 227.300 Professional and technical services. (a) The prohibition on...

20 CFR 438.300 - Professional and technical services.

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2010-04-01

... analysis directly applying any professional or technical discipline. For example, drafting of a legal... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Professional and technical services. 438.300... Other Than Own Employees § 438.300 Professional and technical services. (a) The prohibition on the use...

34 CFR 82.300 - Professional and technical services.

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2010-07-01

... and analysis directly applying any professional or technical discipline. For example, drafting or a... 34 Education 1 2010-07-01 2010-07-01 false Professional and technical services. 82.300 Section 82... by Other Than Own Employees § 82.300 Professional and technical services. (a) The prohibition on the...

20 CFR 410.300 - Relationship and dependency; general.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Relationship and dependency; general. 410.300... OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and Dependency § 410.300 Relationship and dependency; general. (a) In order to establish entitlement to benefits, a widow, child, parent, brother, or...

MindEdit: A P300-based text editor for mobile devices.

Science.gov (United States)

Elsawy, Amr S; Eldawlatly, Seif; Taher, Mohamed; Aly, Gamal M

2017-01-01

Practical application of Brain-Computer Interfaces (BCIs) requires that the whole BCI system be portable. The mobility of BCI systems involves two aspects: making the electroencephalography (EEG) recording devices portable, and developing software applications with low computational complexity to be able to run on low computational-power devices such as tablets and smartphones. This paper addresses the development of MindEdit; a P300-based text editor for Android-based devices. Given the limited resources of mobile devices and their limited computational power, a novel ensemble classifier is utilized that uses Principal Component Analysis (PCA) features to identify P300 evoked potentials from EEG recordings. PCA computations in the proposed method are channel-based as opposed to concatenating all channels as in traditional feature extraction methods; thus, this method has less computational complexity compared to traditional P300 detection methods. The performance of the method is demonstrated on data recorded from MindEdit on an Android tablet using the Emotiv wireless neuroheadset. Results demonstrate the capability of the introduced PCA ensemble classifier to classify P300 data with maximum average accuracy of 78.37±16.09% for cross-validation data and 77.5±19.69% for online test data using only 10 trials per symbol and a 33-character training dataset. Our analysis indicates that the introduced method outperforms traditional feature extraction methods. For a faster operation of MindEdit, a variable number of trials scheme is introduced that resulted in an online average accuracy of 64.17±19.6% and a maximum bitrate of 6.25bit/min. These results demonstrate the efficacy of using the developed BCI application with mobile devices. Copyright © 2016 Elsevier Ltd. All rights reserved.

Phosphorylation of p300 by ATM controls the stability of NBS1

International Nuclear Information System (INIS)

Jang, Eun Ryoung; Choi, Jae Duk; Jeong, Gajin; Lee, Jong-Soo

2010-01-01

Acetyltransferase, p300 is a transcriptional cofactor of signal-responsive transcriptional regulation. The surveillance kinase ataxia-telangiectasia mutated (ATM) plays a central role in regulation of a wide range of cellular DNA damage responses. Here, we investigated whether and how ATM mediates phosphorylation of p300 in response to DNA damage and how p300 phosphorylation is functionally linked to DNA damage. ATM-phosphorylated p300 in vitro and in vivo, in response to DNA damage. Phosphorylation of p300 proteins was observed upon γ-irradiation in ATM + cells but not ATM - cells. Importantly, expression of nonphosphorylatable serine to alanine form of p300 (S106A) destabilized both p300 and NBS1 proteins, after DNA damage. These data demonstrate that ATM transduces a DNA damage signal to p300, and that ATM-dependent phosphorylation of p300 is required for stabilization of NBS1 proteins in response to DNA damage.

13 CFR 300.1 - Introduction and mission.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Introduction and mission. 300.1 Section 300.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... innovation and competitiveness, preparing American regions for growth and success in the worldwide economy...

Electric resistance of nickel and niobium in the temperature range of 300-1300 K

International Nuclear Information System (INIS)

Novikov, I.I.; Roshchupkin, V.V.; Mozgovoj, A.G.; Semashko, N.A.

1982-01-01

The results of experimental investigation of nickel and niobium electric resistance on the wire samples by the potentiometric method in the temperature range of 300-1300 K are presented. Experimental data processing by the least square method is carried out; approximating equations of temperature dependence of the nickel and niobium electric resistance are prepared

Autonomy and job satisfaction for a sample of Greek teachers.

Science.gov (United States)

Koustelios, Athanasios D; Karabatzaki, Despina; Kousteliou, Ioanna

2004-12-01

Analysing the relation between Job Satisfaction and Autonomy in a sample of 300 Greek teachers (114 men and 186 women, 28 to 59 years old) from primary and secondary schools, showed statistically significant positive correlations between Job Satisfaction and Autonomy. Particularly, Autonomy was correlated with Job Itself (.21), Supervision (.22), and the Organizational as a Whole (.27), aspects of Job Satisfaction. Findings are in line with previous studies conducted in different cultural contexts. Percent common variance accounted for is small.

34 CFR 300.106 - Extended school year services.

Science.gov (United States)

2010-07-01

... services means special education and related services that— (1) Are provided to a child with a disability... 34 Education 2 2010-07-01 2010-07-01 false Extended school year services. 300.106 Section 300.106 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION...

11 CFR 300.31 - Receipt of Levin funds.

Science.gov (United States)

2010-01-01

... Levin funds. (a) General rule. Levin funds expended or disbursed by any State, district, or local...) Donation amount limitation—(1) General rule. A State, district, or local committee of a political party... 11 Federal Elections 1 2010-01-01 2010-01-01 false Receipt of Levin funds. 300.31 Section 300.31...

50 CFR 300.182 - HMS international trade permit.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false HMS international trade permit. 300.182... FISHERIES REGULATIONS International Trade Documentation and Tracking Programs for Highly Migratory Species § 300.182 HMS international trade permit. (a) General. An importer, entering for consumption fish or...

34 CFR 300.23 - Individualized education program team.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Individualized education program team. 300.23 Section 300.23 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... education program team. Individualized education program team or IEP Team means a group of individuals...

Process characteristics and design methods for a 300 deg quad OP amp

Science.gov (United States)

Beasom, J. D.; Patterson, R. B., III

1981-01-01

The results of process characterization, circuit design, and reliability studies for the development of a quad OP amplifier intended for use up to 300 C are presented. A dielectrically isolated complementary vertical bipolar process was chosen to fabricate the amplifier in order to eliminate isolation leakage and the possibility of latch up. Characterization of NPN and PNP junctions showed them to be suitable for use up to 300 C. Interconnect reliability was predicted to be greater than four years mean time between failure. Parasitic MOS formation was eliminated by isolation of each device.

45 CFR 149.300 - General reimbursement rules.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false General reimbursement rules. 149.300 Section 149... REQUIREMENTS FOR THE EARLY RETIREE REINSURANCE PROGRAM Reimbursement Methods § 149.300 General reimbursement rules. Reimbursement under this program is conditioned on provision of accurate information by the...

42 CFR 431.300 - Basis and purpose.

Science.gov (United States)

2010-10-01

...) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION Safeguarding Information on... specifies State plan requirements, the types of information to be safeguarded, the conditions for release of... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 431.300 Section 431.300 Public...

50 CFR 300.62 - Annual management measures.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Annual management measures. 300.62 Section... REGULATIONS Pacific Halibut Fisheries § 300.62 Annual management measures. Annual management measures may be... of unloading and weighing, and sport fishing for halibut. The Assistant Administrator will publish...

13 CFR 127.300 - How is a concern certified as an EDWOSB or WOSB?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How is a concern certified as an EDWOSB or WOSB? 127.300 Section 127.300 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Certification of EDWOSB or WOSB Status...

<300> GeV team

CERN Multimedia

CERN PhotoLab

1971-01-01

The 300 GeV team had been assembled. In the photograph are Hans Horisberger, Clemens Zettler, Roy Billinge, Norman Blackburne, John Adams, Hans-Otto Wuster, Lars Persson, Bas de Raad, Hans Goebel, Simon Van der Meer.

34 CFR 300.146 - Responsibility of SEA.

Science.gov (United States)

2010-07-01

... special education and related services— (1) In conformance with an IEP that meets the requirements of... 34 Education 2 2010-07-01 2010-07-01 false Responsibility of SEA. 300.146 Section 300.146 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION...

20 CFR 726.300 - Purpose and scope.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Purpose and scope. 726.300 Section 726.300 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS FOR COAL MINE OPERATOR'S INSURANCE Civil...

34 CFR 300.704 - State-level activities.

Science.gov (United States)

2010-07-01

... mental health services for children with disabilities; (iv) To improve the use of technology in the... 34 Education 2 2010-07-01 2010-07-01 false State-level activities. 300.704 Section 300.704 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION...

10 CFR 300.7 - Net emission reductions.

Science.gov (United States)

2010-01-01

... the likely direct and indirect effects of the actions taken to reduce greenhouse gas emissions. (d... DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.7... gases listed in the definition of “greenhouse gases” in § 300.2 are eligible for registration. (b...

34 CFR 300.601 - State performance plans and data collection.

Science.gov (United States)

2010-07-01

... Monitoring, Technical Assistance, and Enforcement § 300.601 State performance plans and data collection. (a... 34 Education 2 2010-07-01 2010-07-01 false State performance plans and data collection. 300.601... described in § 300.600(d). (b) Data collection. (1) Each State must collect valid and reliable information...

9 CFR 113.300 - General requirements for live virus vaccines.

Science.gov (United States)

2010-01-01

... vaccines. 113.300 Section 113.300 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... REQUIREMENTS Live Virus Vaccines § 113.300 General requirements for live virus vaccines. When prescribed in an applicable Standard Requirement or in the filed Outline of Production, a live virus vaccine shall meet the...

31 CFR 30.0 - Executive compensation and corporate governance.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Executive compensation and corporate governance. 30.0 Section 30.0 Money and Finance: Treasury Office of the Secretary of the Treasury TARP STANDARDS FOR COMPENSATION AND CORPORATE GOVERNANCE § 30.0 Executive compensation and corporate governance...

76 FR 36387 - Airworthiness Directives; Airbus Model A300 Series Airplanes; Model A310 Series Airplanes; and...

Science.gov (United States)

2011-06-22

... pieces unit with 3 welds (old design) as pictured in Appendix 1 of this [EASA] AD. The welding process of... pre-modification 02447.. Blue and Green. A300 airplanes post-modification 02447. Blue. A300-600 airplanes Blue. A310 airplanes Green. Table 2--Applicable service information Airbus mandatory service...

16 CFR 300.7 - English language requirement.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false English language requirement. 300.7 Section... AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.7 English language..., shall appear in the English language. If the product bears any stamp, tag, label, or mark of...

24 CFR 300.17 - Audits and reports.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Audits and reports. 300.17 Section...) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.17 Audits and reports. The Association and its designees may at any reasonable time audit the books and examine...

Safety philosophy of gas turbine high temperature reactor (GTHTR300)

International Nuclear Information System (INIS)

Shoji Katanishi; Kazuhiko Kunitomi; Shusaku Shiozawa

2002-01-01

Japan Atomic Energy Research Institute (JAERI) has undertaken the study of an original design concept of gas turbine high temperature reactor, the GTHTR300. The general concept of this study is development of a greatly simplified design that leads to substantially reduced technical and cost requirements. Newly proposed design features enable the GTHTR300 to be an efficient and economically competitive reactor in 2010's. Also, the GTHTR300 fully takes advantage of its inherent safety characteristics. The safety philosophy of the GTHTR300 is developed based on the HTTR (High Temperature Engineering Test Reactor) of JAERI which is the first HTGR in Japan. Major features of the newly proposed safety philosophy for the GTHTR300 are described in this article. (authors)

Is Bayesian Estimation Proper for Estimating the Individual’s Ability?

Science.gov (United States)

1980-07-15

8217 . LA Q__ .. ’ LL * L .51 , 27 _ :...~ 2,1O34 4 . __8 13 .2, . ,.. 4 .. 04_I ’jag.. * b1 1, 9. 73,-- o __ - 1.., 9 ’.2 ;’ " *~~ 2 2 5g.S , .4. ’ " 0...University of Massechusetts Amherst, MA 01002 ERIC Facility-Acquisitions 4833 Rugby Avenue 1 Dr. Chester Harris Bethesda, MD 20014 School of Education

Beneficial uses program. Progress report for period ending March 31, 1977

Energy Technology Data Exchange (ETDEWEB)

None

1977-07-01

Progress is reported in a program aimed at recovering radiation sources from radioactive wastes and using these sources, mainly /sup 137/Cs, for irradiating sewage sludge. Information is included on: development and cost of dried sludge irradiator; heat and radiation inactivation of sludge-contained viruses and bacteria; virucidal agents in sludge; use of thermoradiated sludge as animal feed; and a comparison of the efficiency of various source materials. (LCL)

41 CFR 60-300.24 - Drugs and alcohol.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Drugs and alcohol. 60-300... VETERANS Discrimination Prohibited § 60-300.24 Drugs and alcohol. (a) Specific activities permitted. The contractor: (1) May prohibit the illegal use of drugs and the use of alcohol at the workplace by all...

P300 event-related potentials in children with dyslexia.

Science.gov (United States)

Papagiannopoulou, Eleni A; Lagopoulos, Jim

2017-04-01

To elucidate the timing and the nature of neural disturbances in dyslexia and to further understand the topographical distribution of these, we examined entire brain regions employing the non-invasive auditory oddball P300 paradigm in children with dyslexia and neurotypical controls. Our findings revealed abnormalities for the dyslexia group in (i) P300 latency, globally, but greatest in frontal brain regions and (ii) decreased P300 amplitude confined to the central brain regions (Fig. 1). These findings reflect abnormalities associated with a diminished capacity to process mental workload as well as delayed processing of this information in children with dyslexia. Furthermore, the topographical distribution of these findings suggests a distinct spatial distribution for the observed P300 abnormalities. This information may be useful in future therapeutic or brain stimulation intervention trials.

Protection against wing icing for Airbus A300 and A310

Science.gov (United States)

Woelfer, G.

1981-01-01

To improve economy of operation, it is now planned to modify the anti-icing system used on the A300 Airbus wing. Thus, for the A310 Airbus, the deicing system will be applied to only half the wing length. Other essential modifications are a substantial simplification of the warm-air system and discontinuation of the use of a double wall in slats.

P300 brain potential among workers exposed to organic solvents

Directory of Open Access Journals (Sweden)

Bente E. Moen

2009-10-01

Full Text Available  SUMMARYThe P300 component of the auditory event-related brain potential was examined in a group of 11workers exposed to low levels of organic solvents in a paint factory and 11 unexposed controls beforeand after 3 weeks of summer vacation. The P300 latency time was found to be prolonged among theexposed workers compared to the reference group before the summer vacation, and to be significantlylonger before the vacation than after in the exposed group.The P300 component was also examined in a group of 85 seamen from chemical tankers, experiencingpeak exposures to organic solvents. They were compared to a reference group of unexposedseamen. Comparing these two groups, no difference was found in the P300 latency time. No relationshipbetween the P300 latency time and exposure was found in a multiple regression analysis, includingthe variables age, alcohol consumption, smoking and cerebral concussions.The study indicates the occurrence of an acute biological effect in the nervous system related toorganic solvent exposure, expressed by prolonged P300 latency time. This was found at very lowexposure levels and should be studied further.

The 300 MW THTR nuclear power plant

International Nuclear Information System (INIS)

Hirschfelder, G.

Because of its schedule being prolonged again and again and its price being steadily increased the THTR 300 like the SNR is getting much public attention. Fortunately this fact apart from the financial difficulties of the Federal and State Governments has resulted in all parties involved in design and construction again making extraordinary efforts to complete and successfully bring into operation the THTR 300 within the scheduled time and within the planned cost limit. Within the past year visible progress has been made, convincing licensing authority, assessors, supplier and future owner all together that the THTR 300 can successfully conclude its trial operation after 164 months of construction time in October 1985 according to the planned schedule and with a total cost of 4 billion DM. This naturally assumes that no unexpected delays, especially by the lawsuits filed, will occur. (orig.) [de

41 CFR 300-1.1 - What is the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is the FTR? 300-1.1 Section 300-1.1 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 1-THE FEDERAL TRAVEL REGULATION (FTR) § 300-1.1 What is the FTR? The FTR is the regulation...

Preliminary Evaluation of PS300: A New Self-Lubricating High Temperature Composite Coating for Use to 800 C

Science.gov (United States)

Dellacorte, C.; Edmonds, B. J.

1995-01-01

This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800 C. PS300 is a metal bonded chrome oxide coating with silver and BaF2/CaF2 eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating, which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650 C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

Hanford 300 Area Development Plan

International Nuclear Information System (INIS)

Daly, K.S.; Seiler, S.W.; Hail, J.C.

1991-09-01

The purpose of the Hanford 300 Area Development Plan (Development Plan) is to guide the physical development of the 300 Area in accordance with US Department of Energy (DOE) Order 4320.1B (DOE 1991b) by performing the following: (1) Establishing a land use plan, setting land use categories that meet the needs of existing and proposed activities; (2) Coordinating existing, 5-yr, and long-range development plans and guiding growth in accordance with those plans; (3) Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities; (4) Identifying site development issues that need further analysis; Integrating program plans with development plans to ensure a logical progression of development; and, (6) Integrating DOE plans with local agency plans (i.e., city, country, state, and Tri-Cities Science and Technology Park plans)

Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.

Science.gov (United States)

Costi, Roberta; Di Santo, Roberto; Artico, Marino; Miele, Gaetano; Valentini, Paola; Novellino, Ettore; Cereseto, Anna

2007-04-19

Cinnamoly compounds 1a-c and 2a-d were designed, synthesized, and in vitro tested as p300 inhibitors. At different degrees, all tested compounds were proven to inactivate p300, particularly, derivative 2c was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases. Most notably, 2c showed anti-acetylase activity in mammalian cells. These compounds represent a new class of synthetic inhibitors of p300, characterized by simple chemical structures.

GTHTR300—A nuclear power plant design with 50% generating efficiency

International Nuclear Information System (INIS)

Sato, Hiroyuki; Yan, Xing L.; Tachibana, Yukio; Kunitomi, Kazuhiko

2014-01-01

Highlights: • GTHTR300 reported 10 years ago is updated. • Cycle and reactor core designs as well as turbine blade material are improved. • The study showed that GTHTR300 is able to yield a net plant efficiency of 50.4%. - Abstract: GTHTR300 is a gas turbine high temperature reactor power generation plant design. The baseline design reported by Japan Atomic Energy Agency a decade ago attained 45.6% net efficiency. Technological improvements have since been made that make further increase in efficiency practical: first, the cycle parameters are upgraded by utilizing the newly acquired design data including those from component tests. Next, the core design is optimized to raise the reactor outlet coolant temperature from the baseline of 850 °C to the level of 950 °C demonstrated on the long-term test reactor operation. Both core physics and thermal hydraulics are investigated to demonstrate the corresponding temperature rise is within the design limit so that the existing fuel design can continue to apply. Finally, an advanced type of turbine blade material that has only recently entered in commercial service in aircraft engine is found to be useable for this design to realize a turbine inlet temperature of 950 °C without requiring blade cooling. As detailed in this paper, these design improvements result in a nearly 5% gain in overall plant efficiency and enable the GTHTR300 to break the 50% efficiency barrier of nuclear plant while using only the existing technologies. This result is expected to contribute to the early market deployment of high temperature gas-cooled reactor

GTHTR300—A nuclear power plant design with 50% generating efficiency

Energy Technology Data Exchange (ETDEWEB)

Sato, Hiroyuki, E-mail: sato.hiroyuki09@jaea.go.jp; Yan, Xing L.; Tachibana, Yukio; Kunitomi, Kazuhiko

2014-08-15

Highlights: • GTHTR300 reported 10 years ago is updated. • Cycle and reactor core designs as well as turbine blade material are improved. • The study showed that GTHTR300 is able to yield a net plant efficiency of 50.4%. - Abstract: GTHTR300 is a gas turbine high temperature reactor power generation plant design. The baseline design reported by Japan Atomic Energy Agency a decade ago attained 45.6% net efficiency. Technological improvements have since been made that make further increase in efficiency practical: first, the cycle parameters are upgraded by utilizing the newly acquired design data including those from component tests. Next, the core design is optimized to raise the reactor outlet coolant temperature from the baseline of 850 °C to the level of 950 °C demonstrated on the long-term test reactor operation. Both core physics and thermal hydraulics are investigated to demonstrate the corresponding temperature rise is within the design limit so that the existing fuel design can continue to apply. Finally, an advanced type of turbine blade material that has only recently entered in commercial service in aircraft engine is found to be useable for this design to realize a turbine inlet temperature of 950 °C without requiring blade cooling. As detailed in this paper, these design improvements result in a nearly 5% gain in overall plant efficiency and enable the GTHTR300 to break the 50% efficiency barrier of nuclear plant while using only the existing technologies. This result is expected to contribute to the early market deployment of high temperature gas-cooled reactor.

Feasibility study of parallel conduction cooling of NbTi magnet and sample probe in a cryogen-free magnet system

Science.gov (United States)

Catarino, I.; Soni, V.; Barreto, J.; Martins, D.; Kar, S.

2017-02-01

The conduction cooling of both a 6 T superconducting magnet along with a sample probe in a parallel configuration is addressed in this work. A Gifford-McMahon (GM) cryocooler is directly cooling the NbTi magnet, which aims to be kept at 4 K, while a gas-gap heat switch (GGHS) manages the cooling power to be diverted to the sample probe, which may be swept from 4 K up to 300 K. A first prototype of a GGHS was customized and validated for this purpose. A sample probe assembly has been designed and assembled with the existing cryogen-free magnet system. The whole test setup and components are described and the preliminary experimental results on the integration are presented and discussed. The magnet was charged up to 3 T with a 4 K sample space and up to 1 T with a sweeping sample space temperature up to 300 K while acting on the GGHS. Despite some identified thermal insulation problems that occurred during this first test, the overall results demonstrated the feasibility of the cryogen-free parallel conduction cooling on study.

P300 is attenuated during dissociative episodes.

Science.gov (United States)

Kirino, Eiji

2006-02-01

The present study examined the pathophysiology of dissociative phenomena using the P300 component of event-related potentials, quantitative electroencephalography (QEEG), and morphology measures of computed tomography scan. Event-related potentials during an auditory oddball paradigm and QEEG in resting state were recorded. Patients exhibited attenuation of P300 amplitudes compared with controls during dissociative episodes, but exhibited recovery to control levels in remission. Patients had a larger Sylvian fissure-brain ratio than did controls. QEEG findings revealed no significant differences between the patients and controls or between episodes and remission in the patient group. Attenuation of the P300 can be interpreted as the result of a negative feedback loop from the medial temporal lobe to the cortex, which decreases the amount of information flow, allocation of attentional resources, and updating of working memory to avoid both excessive long-term memory system activity in medial temporal lobe and resurgence of affect-laden memories.

Design of a 300 GHz Broadband TWT Coupler and RF-Structure

CERN Document Server

Krawczyk, F L

2004-01-01

Recent LANL activities in millimeter wave structures focus on 94 and 300 GHz structures. They aim at power generation from low power (100–2000 W) with a round electron beam (120 kV, 0.1–1.0 A) to high power (2–100 kW) with a sheet beam structure (120 kV, 20 A). Applications cover basic research, radar and secure communications and remote sensing of biological and chemical agents. In this presentation the design and cold-test measurements of a 300 GHz RF-structure with a broadband (>6% bandwidth) power coupler are presented. The design choice of two input/output waveguides, a special coupling region and the structure parameters themselves are presented. As a benchmark also a scaled up version at 10 GHz was designed and measured. These results will also be presented.

Safety philosophy of the GTHTR300

International Nuclear Information System (INIS)

Kunitomi, Kazuhiko; Katanishi, Shoji

2003-01-01

In parallel to successful operation of the Japan's first High Temperature Gas-cooed Reactor, HTTR (High Temperature Engineering Test Reactor), JAERI (Japan Atomic Energy Research Institute) started design and development of a high temperature gas cooled reactor with a gas turbine electric generation system, GTHTR300 (Gas Turbine High Temperature Reactor 300), in April 2001. The GTHTR300 is expected to be deployed in 2010s as a safe and economically competitive electric generation system in Japan. Unique safety philosophy is proposed for this system. Severe accidents are defined as any conditions beyond design base accidents, causing core damages with fission product releases to the environment, although all severe accident sequences are very low in probability. The new safety philosophy is to avoid most accidents, and to achieve a probability of severe accidents of 10 -8 /ry that is at least two orders lower than current reactors. Even in the worst event such as double guillotine break of a primary concentric duct, fuel temperature exceeding its failure limit and excessive fuel oxidation by air ingress can be avoided because of inherent safety features and the passive decay heat removal system. Furthermore, double confinement buildings are enough to keep reactor safety in such accidents. Elimination of a leak-tight steel containment vessel is a big economical advantage for this system. Another unique feature is that nearly full-scale worst accident simulation tests can be carried out to obtain licensing before commercial operations because safety assessment by analysis is not usually enough to convince the public and the regulators of trusting this safety concept. In current reactors no accident simulation tests are carried out before commercial operations although inspection and performance tests in normal condition are conducted. This paper describes the safety philosophy together with the outline of the design features of the GTHTR300, and the results of

East African Soil Erosion Recorded in a 300 Year old Coral Colony From Kenya

Science.gov (United States)

Dunbar, R. B.; Fleitmann, D.; McCulloch, M.; Mudelsee, M.; Vuille, M.; McClanahan, T.; Cole, J.; Eggins, S.

2006-12-01

Soil erosion threatens the food security of 2.6 billion people worldwide. The situation is particularly dire in East and Sub-Saharan Africa where per capita food production has declined over the past 45 years. Erosion and the resultant loss of fertile soil is a key socio-economic and ecological problem in Kenya, affecting all sectors of its economy and damaging marine and terrestrial ecosystems. The temporal pattern of soil erosion is almost unknown and currently only sparse and rather anecdotal information exists. To aid in filling this gap of knowledge, we present a 300-year long Barium record from two Kenyan coral colonies (Porites sp., 3°15'S, 40°9' E; Malindi Marine National Park) that documents a dynamic history of soil erosion in the Sabaki river drainage basin. To reconstruct Sabaki River sediment flux to the Malindi coral reef Ba/Ca ratios were measured in the skeleton of two Porites colonies (Mal 96-1 and Mal 95-3). Well-developed annual bands allow us to develop annually precise chronologies. Ba/Ca ratios were measured in core Mal 96-1 at continuous 40 μm intervals (~400 to 500 samples yr-1) using laser-ablation inductively coupled plasma mass spectrometry (LA- ICP-MS). To test for reproducibility and accuracy of the Mal 96-1 Ba/Ca profile, coral core Mal 95-3 was analyzed at lower resolution (1 to 12 samples yr-1) using discrete micro-drill sampling and isotope dilution ICP-MS. The close similarity between both coral Ba/Ca profiles, in absolute values as well as general pattern, underscores the accuracy of the LA-ICP-MS technique and adds confidence to our interpretation of the 300 year long Mal 96-1 Ba/Ca profile. The Ba/Ca coral proxy record shows that while the sediment flux from the Sabaki River is nearly constant between 1700 and 1900, a continuous rise in sediment flux is observed since 1900, reflecting steadily increasing demographic pressure on land use. The peak in suspended sediment load and hence soil erosion recorded at the Malindi reef

[The P300 based brain-computer interface: effect of stimulus position in a stimulus train].

Science.gov (United States)

Ganin, I P; Shishkin, S L; Kochetova, A G; Kaplan, A Ia

2012-01-01

The P300 brain-computer interface (BCI) is currently the most efficient BCI. This interface is based on detection of the P300 wave of the brain potentials evoked when a symbol related to the intended input is highlighted. To increase operation speed of the P300 BCI, reduction of the number of stimuli repetitions is needed. This reduction leads to increase of the relative contribution to the input symbol detection from the reaction to the first target stimulus. It is known that the event-related potentials (ERP) to the first stimulus presentations can be different from the ERP to stimuli presented latter. In particular, the amplitude of responses to the first stimulus presentations is often increased, which is beneficial for their recognition by the BCI. However, this effect was not studied within the BCI framework. The current study examined the ERP obtained from healthy participants (n = 14) in the standard P300 BCI paradigm using 10 trials, as well as in the modified P300 BCI with stimuli presented on moving objects in triple-trial (n = 6) and single-trial (n = 6) stimulation modes. Increased ERP amplitude was observed in response to the first target stimuli in both conditions, as well as in the single-trial mode comparing to triple-trial. We discuss the prospects of using the specific features of the ERP to first stimuli and the single-trial ERP for optimizing the high-speed modes in the P300 BCIs.

Clinical application of iopamidol (pamiray 300) for cerebral angiography

International Nuclear Information System (INIS)

Park, Sung Ho; Suh, Sang Hyun; Kim, Jin Na; Kim, Eung Yeop; Kim, Dong Joon; Lee, Seung Koo; Kim, Dong Ik

2007-01-01

The aim of this study was to assess the clinical safety and efficacy of Pamiray 300 (Iopamidol; Dongkook Pharm, Seoul, Korea) as a nonionic contrast medium for cerebral angiography. One hundred patients undergoing cerebral angiography were randomly assigned to receive Pamiray 300 after written consent had been obtained. Patients with adverse reactions were divided into two groups. One group consisted of patients with minor adverse events such as heat sensation and pain, and the other group consisted of patients with major adverse events such as dyspnea, laryngeal edema and shock. The qualities of the radiographic images were stratified into five grades by three independent radiologists. No abnormality induced by Pamiray 300 was seen by a physical and neurological examination, blood pressure measurement, electrocardiogram, respiration rate measurement and partial fraction of arterial oxygen recording. No major and severe adverse events occurred throughout the study. Patient sex, age, disease category, underlying disease and administered contrast dosage showed no statistical significance with regards to the occurrence of adverse events. The opacification of blood vessels in all patients was 'good' or 'excellent'. Based on the results of this study, Pamiray 300 is a safe, efficacious and well-tolerated contrast medium for use in cerebral angiography. Thus, Pamiray 300 can be used as a competitive medium in cerebral angiography

Regional cerebral blood flow and P300 in neurosurgical disorders

International Nuclear Information System (INIS)

Funahashi, Kazuyoshi; Hyoutani, Genhachi; Maeshima, Shinichirou; Miyamoto, Kazuki; Kuwata, Toshikazu; Terada, Tomoaki; Komai, Norihiko

1990-01-01

Changes in regional cerebral blood flow (rCBF), P300 and higher brain function were studied in neurosurgical patients with localized lesions on computed tomography (CT). Twenty-five patients ranging in age from 30 to 81 were studied. Nineteen of these suffered from cerebrovascular disease and six had tumors. Using the oddball paradigm, P300 components were elicited by rate tones (2 KHz) and recorded at Cz and Pz referred to linked ear-lobe electorodes. The P300 latencies of the patients were statistically compared with those of 27 normal subjects. Higher brain function was evaluated with the following psychological tests: a rating scale for psychological function (Sano and Tanemura), Mini-Mental State (MMS), Hasegawa's Dementia Scale (HDS) and the 'Kanahiroi' test. Regional CBF was measured in the bilateral cerebral cortices (the frontal, temporal and occipital lobes), thalamus and basal ganglia by means of a cold xenon CT method. The laterality indices of rCBF (Rt. rCBF/Lt. rCBF) in the bilateral symmetrical areas of the patients were compared to those of 8 normal subjects. Of the 25 patients, 12 revealed prolongation of P300 latency. Ten (86%) of the 12 with prolonged P300 latency showed reduction of rCBF in the right cerebral hemisphere (rt. frontal lobe, rt. thalamus and rt. basal ganglia). Significant correlations (P<0.025) were recognized between the P300 latencies and the laterality indices of rCBF in the frontal lobe and thalamus. There was a significant correlation (P<0.05) between the scores of MMS and HDS and the laterality indicies of rCBF in the frontal lobe only. In the 13 patients with normal P300 latency, 6 (46%) displayed no reduction in rCBF. The remaining 7 patients with normal P300 showed reduction of rCBF in the left hemisphere. Both right frontal lobe and right thalamus have an important role affecting the prolongation of P300 latency and disturbance of cognitive functions. (author)

41 CFR 102-34.300 - How do we dispose of a domestic fleet motor vehicle?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How do we dispose of a domestic fleet motor vehicle? 102-34.300 Section 102-34.300 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY...

Basic policy of maintenance for the power conversion system of the gas turbine high temperature reactor 300 (GTHTR300)

International Nuclear Information System (INIS)

Kosugiyama, Shinichi; Takizuka, Takakazu; Kunitomi, Kazuhiko; Yan, Xing; Katanishi, Shoji; Takada, Shoji

2003-01-01

Basic policy of maintenance was determined for major equipment in the power conversion system of the Gas Turbine High Temperature Reactor 300 (GTHTR300). It was developed based on the current maintenance practice in Light Water Reactors (LWRs), High Temperature Engineering Test Reactor (HTTR) and conventional combined cycle power plants while taking into account of unique design features of GTHTR300. First, potential degradation phenomena in operations were identified and corresponding maintenance approaches were proposed for the equipment. Such degradations encountered typically in LWRs as corrosion, erosion and stress corrosion cracking are unlikely to occur since the working fluid of GTHTR300 is inert helium. Main causes of the degradations are high operating temperature and pressure. The gas turbine, compressor, generator, control valves undergo opening and dismantling maintenance in a suitable time interval. The power conversion vessel, heat exchanger vessel, primary system piping and heat exchanging tubes of precooler are subjected to in-service inspections similar to those done in LWRs. As turbine blades represent the severest material degradation because of their high-temperature and high-stress operating conditions, a lifetime management scheme was suggested for them. The longest interval of open-casing maintenance of the gas turbine is estimated to be six to seven years from technical point of view. Present study is entrusted from the Ministry of Education, Culture, Sports, Science and Technology of Japan. (author)

Performance analysis of a Principal Component Analysis ensemble classifier for Emotiv headset P300 spellers.

Science.gov (United States)

Elsawy, Amr S; Eldawlatly, Seif; Taher, Mohamed; Aly, Gamal M

2014-01-01

The current trend to use Brain-Computer Interfaces (BCIs) with mobile devices mandates the development of efficient EEG data processing methods. In this paper, we demonstrate the performance of a Principal Component Analysis (PCA) ensemble classifier for P300-based spellers. We recorded EEG data from multiple subjects using the Emotiv neuroheadset in the context of a classical oddball P300 speller paradigm. We compare the performance of the proposed ensemble classifier to the performance of traditional feature extraction and classifier methods. Our results demonstrate the capability of the PCA ensemble classifier to classify P300 data recorded using the Emotiv neuroheadset with an average accuracy of 86.29% on cross-validation data. In addition, offline testing of the recorded data reveals an average classification accuracy of 73.3% that is significantly higher than that achieved using traditional methods. Finally, we demonstrate the effect of the parameters of the P300 speller paradigm on the performance of the method.

Developing a 300C Analog Tool for EGS

Energy Technology Data Exchange (ETDEWEB)

Normann, Randy

2015-03-23

This paper covers the development of a 300°C geothermal well monitoring tool for supporting future EGS (enhanced geothermal systems) power production. This is the first of 3 tools planed. This is an analog tool designed for monitoring well pressure and temperature. There is discussion on 3 different circuit topologies and the development of the supporting surface electronics and software. There is information on testing electronic circuits and component. One of the major components is the cable used to connect the analog tool to the surface.

41 CFR 105-69.300 - Professional and technical services.

Science.gov (United States)

2010-07-01

... or technical discipline. For example, drafting or a legal document accompanying a bid or proposal by... technical services. 105-69.300 Section 105-69.300 Public Contracts and Property Management Federal Property... and technical services. (a) The prohibition on the use of appropriated funds, in § 105-69.100 (a...

Apparatus for gas phase studies at lambda greater than or equal to 300 A

International Nuclear Information System (INIS)

Grover, J.R.; White, M.G.

1981-01-01

An apparatus is being built to achieve four criteria: (1) a working region of wavelengths from 300 A to 2000 A; (2) absence of all orders higher than the first; (3) intensities as high as possible; (4) able to deal with a significant gas load in the experimental chamber. In exchange for high intensity and excellent order sorting it is acceptable to have only modest resolution, and to forego wavelengths shorter than 300 A

Pilot project of a small 300 W fuel-cell-powered electrical boat; Projet pilote d'une petite embarcation mue par pile a combustible de 300 W

Energy Technology Data Exchange (ETDEWEB)

Affolter, J.-F.

2000-07-01

The important demand at the European level for electrical boats shows the great interest for such a technology. We can expect an important growth of electric boats production. Thus, two means could be used to provide a maximum of comfort, reliability, silence, absence of pollution and respect of the environment: photovoltaics and fuel cells. The purpose of the present project is to explore the second solution. A small boat 'Hydroxy100' has been designed as first prototype in the field of a diploma work. A larger boat, 'Hydroxy300', with the use of a 300-watt PEFC fuel cell was realised and successfully presented at the international fuel cells meeting in Lucerne (June 99) and other occasions. The subject is also an excellent didactical application for the electrical degree students of our technical university. (author)

29 CFR 541.300 - General rule for professional employees.

Science.gov (United States)

2010-07-01

... REGULATIONS DEFINING AND DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES Professional Employees § 541.300 General rule for professional employees. (a) The... 29 Labor 3 2010-07-01 2010-07-01 false General rule for professional employees. 541.300 Section...

Preparation of thermoluminescent materials

International Nuclear Information System (INIS)

1976-01-01

Thermoluminescent materials have been found to be suitable for measuring long term exposures to low level ionizing radiation. Oxyhalides of lanthanum, gadolinium and yttrium, including the oxychlorides and oxybromides are activated with terbium and have been found to be most efficient oxygendominated phosphors having thermoradiant efficiencies with excitation by low level ionizing radiation. Thermoluminescence response increases when the previous materials have hafnium and zirconium additives

A novel task-oriented optimal design for P300-based brain-computer interfaces.

Science.gov (United States)

Zhou, Zongtan; Yin, Erwei; Liu, Yang; Jiang, Jun; Hu, Dewen

2014-10-01

Objective. The number of items of a P300-based brain-computer interface (BCI) should be adjustable in accordance with the requirements of the specific tasks. To address this issue, we propose a novel task-oriented optimal approach aimed at increasing the performance of general P300 BCIs with different numbers of items. Approach. First, we proposed a stimulus presentation with variable dimensions (VD) paradigm as a generalization of the conventional single-character (SC) and row-column (RC) stimulus paradigms. Furthermore, an embedding design approach was employed for any given number of items. Finally, based on the score-P model of each subject, the VD flash pattern was selected by a linear interpolation approach for a certain task. Main results. The results indicate that the optimal BCI design consistently outperforms the conventional approaches, i.e., the SC and RC paradigms. Specifically, there is significant improvement in the practical information transfer rate for a large number of items. Significance. The results suggest that the proposed optimal approach would provide useful guidance in the practical design of general P300-based BCIs.

Transcriptional profiling of human monocytes identifies the inhibitory receptor CD300a as regulator of transendothelial migration.

Directory of Open Access Journals (Sweden)

Sharang Ghavampour

Full Text Available Local inflammatory responses are characterized by the recruitment of circulating leukocytes from the blood to sites of inflammation, a process requiring the directed migration of leukocytes across the vessel wall and hence a penetration of the endothelial lining. To identify underlying signalling events and novel factors involved in these processes we screened for genes differentially expressed in human monocytes following their adhesion to and passage through an endothelial monolayer. Functional annotation clustering of the genes identified revealed an overrepresentation of those associated with inflammation/immune response, in particular early monocyte to macrophage differentiation. Among the gene products so far not implicated in monocyte transendothelial migration was the inhibitory immune receptor CD300a. CD300a mRNA and protein levels were upregulated following transmigration and engagement of the receptor by anti-CD300a antibodies markedly reduced monocyte transendothelial migration. In contrast, siRNA mediated downregulation of CD300a in human monocytes increased their rate of migration. CD300a colocalized and cosedimented with actin filaments and, when activated, caused F-actin cytoskeleton alterations. Thus, monocyte transendothelial migration is accompanied by an elevation of CD300a which serves an inhibitory function possibly required for termination of the actual transmigration.

Intrahost Evolution of Methicillin-Resistant Staphylococcus aureus USA300 Among Individuals With Reoccurring Skin and Soft-Tissue Infections.

Science.gov (United States)

Azarian, Taj; Daum, Robert S; Petty, Lindsay A; Steinbeck, Jenny L; Yin, Zachary; Nolan, David; Boyle-Vavra, Susan; Hanage, W P; Salemi, Marco; David, Michael Z

2016-09-15

Methicillin-resistant Staphylococcus aureus (MRSA) USA300 is the leading cause of MRSA infections in the United States and has caused an epidemic of skin and soft-tissue infections. Recurrent infections with USA300 MRSA are common, yet intrahost evolution during persistence on an individual has not been studied. This gap hinders the ability to clinically manage recurrent infections and reconstruct transmission networks. To characterize bacterial intrahost evolution, we examined the clinical courses of 4 subjects with 3-6 recurrent USA300 MRSA infections, using patient clinical data, including antibiotic exposure history, and whole-genome sequencing and phylogenetic analysis of all available MRSA isolates (n = 29). Among sequential isolates, we found variability in diversity, accumulation of mutations, and mobile genetic elements. Selection for antimicrobial-resistant populations was observed through both an increase in the number of plasmids conferring multidrug resistance and strain replacement by a resistant population. Two of 4 subjects had strain replacement with a genetically distinct USA300 MRSA population. During a 5-year period in 4 subjects, we identified development of antimicrobial resistance, intrahost evolution, and strain replacement among isolates from patients with recurrent MRSA infections. This calls into question the efficacy of decolonization to prevent recurrent infections and highlights the adaptive potential of USA300 and the need for effective sampling. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Gordon Research Conference on Chronobiology

Science.gov (United States)

1993-11-01

AMHERST MA 01002 DR ANTONI DIEZ-NOGUERA OFF UNIVERSITY OF BARCELONA 3434907869 LABORATORY DE FISIOLOGIA ATTENDEE FACULTAT 03 FARMACIA, AV JOAN XXIII SIN...WALTHAM MA 02254 DR BEATRIZ FUENTES-PARDO P 303 UNIV. NACIONAL AUTONOMA DE MEXICO 525-623-2362 DEPARTAMENTO DE FISIOLOGIA , FAC. DE KED. ATTENDEE APDO...Vilaplana, T.Cambras (Laboratori de Fisiologia , Facultat de Farmacia, Universitat de Barcelona): Effects of period length of light/dark cycles in the

Divergent Pathways and Competitive Mechanisms of Metathesis Reactions between 3-Arylprop-2-ynyl Esters and Aldehydes: An Experimental and Theoretical Study

Czech Academy of Sciences Publication Activity Database

Trujillo, Cristina; Sanchez-Sanz, Goar; Karpavičiene, I.; Jahn, Ullrich; Čikotiene, I.; Rulíšek, Lubomír

2014-01-01

Roč. 20, č. 33 (2014), s. 10360-10370 ISSN 0947-6539 R&D Projects: GA ČR(CZ) GA14-31419S Grant - others:European Social Fund(XE) VP1-3.1-SMM-07 K-01-002 Institutional support: RVO:61388963 Keywords : 3-arylprop-2-ynyl esters * density functional calculations * isotopic labeling * ketones * Morita-Baylis-Hillman adducts Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 5.731, year: 2014

41 CFR 101-26.300 - Scope of subpart.

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of subpart. 101-26.300 Section 101-26.300 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND...

27 CFR 24.300 - General.

Science.gov (United States)

2010-04-01

... spirits, bulk wine bottled, bulk and bottled wine received in bond, taxpaid wine returned to bond, bottled... fermentation, sweetening, blending, amelioration or addition of wine spirits, bulk wine bottled, bulk and... TREASURY LIQUORS WINE Records and Reports § 24.300 General. (a) Records and reports. A proprietor who...

Cleanup Verification Package for the 300 VTS Waste Site

International Nuclear Information System (INIS)

Clark, S.W.; Mitchell, T.H.

2006-01-01

This cleanup verification package documents completion of remedial action for the 300 Area Vitrification Test Site, also known as the 300 VTS site. The site was used by Pacific Northwest National Laboratory as a field demonstration site for in situ vitrification of soils containing simulated waste

Cleanup Verification Package for the 300 VTS Waste Site

Energy Technology Data Exchange (ETDEWEB)

S. W. Clark and T. H. Mitchell

2006-03-13

This cleanup verification package documents completion of remedial action for the 300 Area Vitrification Test Site, also known as the 300 VTS site. The site was used by Pacific Northwest National Laboratory as a field demonstration site for in situ vitrification of soils containing simulated waste.

34 CFR 300.515 - Timelines and convenience of hearings and reviews.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Timelines and convenience of hearings and reviews. 300.515 Section 300.515 Education Regulations of the Offices of the Department of Education (Continued... and Children § 300.515 Timelines and convenience of hearings and reviews. (a) The public agency must...

Convergence measurements in a 300 m deep borehole in rock salt

International Nuclear Information System (INIS)

Heijdra, J.J.; Prij, J.

1992-05-01

An evaluation is presented of convergence measurements in a 300 m deep borehole in rock salt. The measured convergence is compared to the normalized convergence based on an analytical solution. Measurements endorse the assumptions on which the analytical solution has been based. With the aid of this analytical solution the ambient rock pressure at the locations of the measurements is determined. The derived pressures and the corresponding depth below the 750 m level are 20.3 MPa at -300 m, 15.4 MPa at -200 m and 13.3 MPa at -100 m. The measurements, normalized in order to account for the influence of the diameter and for the difference in depth, show good correspondence with former measurements on selected cavities in rock salt. (author). 6 refs.; 17 figs.; 3 tabs

18 CFR 1317.300 - Admission.

Science.gov (United States)

2010-04-01

... Section 1317.300 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON... education program or activity in question and alternative tests or criteria that do not have such a disproportionately adverse effect are shown to be unavailable. (c) Prohibitions relating to marital or parental...

34 CFR 300.26 - Institution of higher education.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Institution of higher education. 300.26 Section 300.26 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

49 CFR 179.300-10 - Postweld heat treatment.

Science.gov (United States)

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment. 179.300-10 Section 179.300-10 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS... Postweld heat treatment. After welding is complete, steel tanks and all attachments welded thereto, must be...

34 CFR 300.17 - Free appropriate public education.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Free appropriate public education. 300.17 Section 300.17 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF...

Clinical application of iopamidol (pamiray 300) for cerebral angiography

Energy Technology Data Exchange (ETDEWEB)

Park, Sung Ho; Suh, Sang Hyun; Kim, Jin Na; Kim, Eung Yeop; Kim, Dong Joon; Lee, Seung Koo; Kim, Dong Ik [Yonsei University College of Medicine, Seoul (Korea, Republic of)

2007-08-15

The aim of this study was to assess the clinical safety and efficacy of Pamiray 300 (Iopamidol; Dongkook Pharm, Seoul, Korea) as a nonionic contrast medium for cerebral angiography. One hundred patients undergoing cerebral angiography were randomly assigned to receive Pamiray 300 after written consent had been obtained. Patients with adverse reactions were divided into two groups. One group consisted of patients with minor adverse events such as heat sensation and pain, and the other group consisted of patients with major adverse events such as dyspnea, laryngeal edema and shock. The qualities of the radiographic images were stratified into five grades by three independent radiologists. No abnormality induced by Pamiray 300 was seen by a physical and neurological examination, blood pressure measurement, electrocardiogram, respiration rate measurement and partial fraction of arterial oxygen recording. No major and severe adverse events occurred throughout the study. Patient sex, age, disease category, underlying disease and administered contrast dosage showed no statistical significance with regards to the occurrence of adverse events. The opacification of blood vessels in all patients was 'good' or 'excellent'. Based on the results of this study, Pamiray 300 is a safe, efficacious and well-tolerated contrast medium for use in cerebral angiography. Thus, Pamiray 300 can be used as a competitive medium in cerebral angiography.

75 FR 7942 - Airworthiness Directives; Airbus Model A310-203, -221, -222 Airplanes; and Model A300 F4-605R and...

Science.gov (United States)

2010-02-23

... Airworthiness Directives; Airbus Model A310-203, -221, -222 Airplanes; and Model A300 F4-605R and -622R...-222 airplanes, all serial numbers. (2) Airbus Model A300 F4-605R and A300 F4-622R airplanes, all...

34 CFR 300.101 - Free appropriate public education (FAPE).

Science.gov (United States)

2010-07-01

... EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Fape Requirements § 300.101 Free appropriate... ensure that FAPE is available to any individual child with a disability who needs special education and... 34 Education 2 2010-07-01 2010-07-01 false Free appropriate public education (FAPE). 300.101...

Adaptation in P300 braincomputer interfaces: A two-classifier cotraining approach

DEFF Research Database (Denmark)

Panicker, Rajesh C.; Sun, Ying; Puthusserypady, Sadasivan

2010-01-01

A cotraining-based approach is introduced for constructing high-performance classifiers for P300-based braincomputer interfaces (BCIs), which were trained from very little data. It uses two classifiers: Fishers linear discriminant analysis and Bayesian linear discriminant analysis progressively...

Molecular beam sampling from a rocket-motor combustion chamber

International Nuclear Information System (INIS)

Houseman, John; Young, W.S.

1974-01-01

A molecular-beam mass-spectrometer sampling apparatus has been developed to study the reactive species concentrations as a function of position in a rocket-motor combustion chamber. Unique design features of the sampling system include (a) the use of a multiple-nozzle end plate for preserving the nonuniform properties of the flow field inside the combustion chamber, (b) the use of a water-injection heat shield, and (c) the use of a 300 CFM mechanical pump for the first vacuum stage (eliminating the use of a huge conventional oil booster pump). Preliminary rocket-motor tests have been performed using the highly reactive propellants nitrogen tetroxide/hydrazine (N 2 O 4 /N 2 H 4 ) at an oxidizer/fuel ratio of 1.2 by weight. The combustion-chamber pressure is approximately 60psig. Qualitative results on unreacted oxidizer/fuel ratio, relative abundance of oxidizer and fuel fragments, and HN 3 distribution across the chamber are presented

300 Area waste acid treatment system closure plan

International Nuclear Information System (INIS)

LUKE, S.N.

1999-01-01

The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOERL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion includes closure plan documentation submitted for individual, treatment, storage, and/or disposal units undergoing closure, such as the 300 Area Waste Acid Treatment System. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Whenever appropriate, 300 Area Waste Acid Treatment System documentation makes cross-reference to the General Information Portion, rather than duplicating text. This 300 Area Waste Acid Treatment System Closure Plan (Revision 2) includes a Hanford Facility Dangerous Waste Permit Application, Part A, Form 3. Information provided in this closure plan is current as of April 1999

300 Area waste acid treatment system closure plan

Energy Technology Data Exchange (ETDEWEB)

LUKE, S.N.

1999-05-17

The Hanford Facility Dangerous Waste Permit Application is considered to be a single application organized into a General Information Portion (document number DOERL-91-28) and a Unit-Specific Portion. The scope of the Unit-Specific Portion includes closure plan documentation submitted for individual, treatment, storage, and/or disposal units undergoing closure, such as the 300 Area Waste Acid Treatment System. Documentation contained in the General Information Portion is broader in nature and could be used by multiple treatment, storage, and/or disposal units (e.g., the glossary provided in the General Information Portion). Whenever appropriate, 300 Area Waste Acid Treatment System documentation makes cross-reference to the General Information Portion, rather than duplicating text. This 300 Area Waste Acid Treatment System Closure Plan (Revision 2) includes a Hanford Facility Dangerous Waste Permit Application, Part A, Form 3. Information provided in this closure plan is current as of April 1999.

26 CFR 300.7 - Enrollment of enrolled actuary fee.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Enrollment of enrolled actuary fee. 300.7... AND ADMINISTRATION USER FEES § 300.7 Enrollment of enrolled actuary fee. (a) Applicability. This section applies to the initial enrollment of enrolled actuaries with the Joint Board for the Enrollment of...

Deutsch 100, 200, 300.

Science.gov (United States)

Manitoba Dept. of Education, Winnipeg.

Manitoba's curriculum guide for German 100, 200, and 300 is designed to (1) make teachers of these courses aware of the official policy concerning the nature, goals, and objectives of the courses and approved teaching materials, and (2) provide instructional guidelines. The guide provides information about three sets of teaching materials from…

The use of combined radiation methods for decreasing the bacterial dissemination of enzyme preparations

International Nuclear Information System (INIS)

Samojlenko, I.I.; Fedotov, N.S.; Tumanyan, M.A.; Korolev, N.I.

1984-01-01

A study was made on possibility of using ionizing radiation in combination with alternative magnetic field (AMF) and heating for decreasing the bacterial dissemination of proteolytic enzymes. Papain, trypsin, chymotrypsin and amylorysin (the preparation possessing proteolytic and amylolytic activities) were subjected to gamma irradiation at 10-25 kGy dose range, the effect of AMF with 750 oe and heating at 50 deg during 60 min. Model tests conducted with the use of Escherichia Coli cells and Bacillus anthracoides spores showed that survival rate of bacteria irradiated in protective medium was lower in the case of combined magnetoradiation and thermoradiation effect. The use of 10 kGy dose of ionizing radiation in combination with treatment in alternative magnetic field or with heating provided the required decrease of dissemination of irradiated enzyme samples with complete conservation of proteolytic activity by them

49 CFR 372.300 - Distances and population data.

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Distances and population data. 372.300 Section 372..., COMMERCIAL ZONES, AND TERMINAL AREAS Terminal Areas § 372.300 Distances and population data. In the application of this subpart, distances and population data shall be determined in the same manner as provided...

34 CFR 300.112 - Individualized education programs (IEP).

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Individualized education programs (IEP). 300.112 Section 300.112 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... education programs (IEP). The State must ensure that an IEP, or an IFSP that meets the requirements of...

34 CFR 300.103 - FAPE-methods and payments.

Science.gov (United States)

2010-07-01

... for special education and related services to the child is being determined. (Approved by the Office... 34 Education 2 2010-07-01 2010-07-01 false FAPE-methods and payments. 300.103 Section 300.103 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION...

Preliminary evaluation of PS300: A new self-lubricating high temperature composite coating for use to 800{degrees}C

Energy Technology Data Exchange (ETDEWEB)

DellaCorte, C.; Edmonds, B.J.

1996-12-31

This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800{degrees}C. PS300 is a metal bonded chrome oxide coating with silver and BaF{sub 2}/CaF{sub 2} eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating; which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650{degrees}C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

Stability of genetic and environmental influences on P300 amplitude: A longitudinal study in adolescent twins.

NARCIS (Netherlands)

van Beijsterveldt, C.E.; van Baal, G.C.; Molenaar, P.C.M.; Boomsma, D.I.; Geus, E.J.

2001-01-01

Examined the stability of genetic and environmental influences on individual differences in P300 amplitude during adolescence. The P300 component is an event-related brain potential (ERP) that has attracted much attention as a biological marker for disturbed cognitive processing in psychopathology.

Safety design philosophy of gas turbine high temperature reactor (GTHTR300)

International Nuclear Information System (INIS)

Katanishi, Shoji; Kunitomi, Kazuhiko

2003-01-01

Japan Atomic Energy Research Institute has been developing design studies of the Gas Turbine High Temperature Reactor (GTHTR300). The original safety design philosophy has also been discussed and fixed for the GTHTR300. One of the unique feature of the safety philosophy of the GTHTR300 is that a depressurization accident is postulated as a design basis accident in order to show the high level of safety characteristics, though its probability of occurrence is much lower than the probability range of design basis accident. Another feature of safety design is to adopt a double confinement that is one of the original concepts for the GTHTR300. By using a double confinement, a feasibility of safety design without containment vessel was clarified even in case of a depressurization accident. This article describes the safety design philosophy and some results of preliminary evaluations which were conducted in order to clarify the feasibility of original safety design of the GTHTR300. (author)

Super ACO FEL oscillation at 300 nm

CERN Document Server

Nutarelli, D; Renault, E; Nahon, L; Couprie, Marie Emmanuelle

2000-01-01

Some recent improvements, involving both the optical cavity mirrors and the positron beam dynamics in the storage ring, have allowed us to achieve a laser oscillation at 300 nm on the Super ACO Storage Ring FEL. The Super ACO storage ring is operated at 800 MeV which is the nominal energy for the usual synchrotron radiation users, and the highest energy for a storage ring FEL. The lasing at 300 nm could be kept during 2 h per injection, with a stored current ranging between 30 and 60 mA. The FEL characteristics are presented here. The longitudinal stability and the FEL optics behaviour are also discussed.

SORE - a pulse stretcher for the Saskatchewan 300-MeV linac

International Nuclear Information System (INIS)

Bergstrom, J.C.; Caplan, H.S.; Norum, B.E.; Servranckx, R.V.

1983-01-01

A design study has been made of a pulse stretcher to increase the duty factor of the 300 MeV electron accelerator of the Saskatchewan Accelerator Laboratory. The design was constrained by the desire to house the pulse stretcher within the existing accelerator building and to make maximal use of existing beam transport lines. The pulse stretcher ring consists of two 180 0 bend regions connected by achromatic straight sections. The overall length is 50.49 m and the width is 6.64m. The modes of injection and extraction will be available. In the first mode a shortened linac pulse of 300 ns duration will be injected during a single turn directly into the closed orbit of the pulse stretcher. A second mode of injection/extraction involves use of a longer linac pulse. The basic geometry of the PSR is dictated by the dimensions of the accelerator vault and access room

Connecting the P300 to the diagnosis and prognosis of unconscious patients

Directory of Open Access Journals (Sweden)

Ran Li

2015-01-01

Full Text Available The residual consciousness of unconscious patients can be detected by studying the P300, a wave among event-related potentials. Previous studies have applied tones, the subject′s name and other names as stimuli. However, the results were not satisfactory. In this study, we changed the constituent order of subjects′two-character names to create derived names. The subject′s derived names, together with tones and their own names, were used as auditory stimuli in event-related potential experiments. Healthy controls and unconscious patients were included in this study and made to listen to these auditory stimuli. In the two paradigms, a sine tone followed by the subject′s own name and the subject′s derived name followed by the subject′s own name were used as standard and deviant stimuli, respectively. The results showed that all healthy controls had the P300 using both paradigms, and that the P300 in the second paradigm had a longer latency and two peaks. All minimally conscious state patients had the P300 in the first paradigm and the majority of them had the P300 in the second paradigm. Most vegetative state patients had no P300. Patients who showed the P300 in the two paradigms had more residual consciousness, and patients with the two-peak P300 had a higher probability of awakening within a short time. Our experimental findings suggest that the P300 event-related potential could reflect the conscious state of unconscious patients.

JB-300: An advanced medium size transport for 2005

Science.gov (United States)

Debrouwer, Giles; Graham, Katherine; Ison, Jim; Juarez, Vince; Moskalik, Steve; Pankonin, Jon; Weinstein, Arnold

1993-01-01

In the fall of 1992, the TAC Team was presented with a Request for Proposal (PFP) for a mid-size (250-350 passenger) commercial transport. The aircraft was to be extremely competitive in the areas of passenger comfort, performance, and economic aspects. Through the use of supercritical airfoils, a technologically advanced Very High By-pass Ratio (VHBR) turbofan engine, a low overall drag configuration, a comparable interior layout, and mild use of composites, the JB-300 offers an economically viable choice to the airlines. The cents per passenger mile of the JB-300 is 1.76, which is considerably lower than current aircraft in the same range. Overall, the JB-300 is a technologically advanced aircraft, which will meet the demands of the 21st century.

40 CFR 300.135 - Response operations.

Science.gov (United States)

2010-07-01

... discharge is a worst case discharge as discussed in § 300.324; the pathways to human and environmental... Health Administration (OSHA) and HHS for assistance on worker health and safety issues. (i) All federal...

Stability of genetic and environmental influences om P300 amplitude: a longitudinal study in adolescent twins

NARCIS (Netherlands)

van Beijsterveldt, C.E.M.; van Baal, G.C.M.; Molenaar, P.C.M.; Boomsma, D.I.; de Geus, E.J.C.

2001-01-01

This study examined the stability of genetic and environmental influences on individual differences in P300 amplitude during adolescence. The P300 component is an event-related brain potential (ERP) that has attracted much attention as a biological marker for disturbed cognitive processing in

Dynamic (G2) Model Design Document, 24590-WTP-MDD-PR-01-002, Rev. 12

Energy Technology Data Exchange (ETDEWEB)

Deng, Yueying; Kruger, Albert A.

2013-12-16

The Hanford Tank Waste Treatment and Immobilization Plant (WTP) Statement of Work (Department of Energy Contract DE-AC27-01RV14136, Section C) requires the contractor to develop and use process models for flowsheet analyses and pre-operational planning assessments. The Dynamic (G2) Flowsheet is a discrete-time process model that enables the project to evaluate impacts to throughput from eventdriven activities such as pumping, sampling, storage, recycle, separation, and chemical reactions. The model is developed by the Process Engineering (PE) department, and is based on the Flowsheet Bases, Assumptions, and Requirements Document (24590-WTP-RPT-PT-02-005), commonly called the BARD. The terminologies of Dynamic (G2) Flowsheet and Dynamic (G2) Model are interchangeable in this document. The foundation of this model is a dynamic material balance governed by prescribed initial conditions, boundary conditions, and operating logic. The dynamic material balance is achieved by tracking the storage and material flows within the plant as time increments. The initial conditions include a feed vector that represents the waste compositions and delivery sequence of the Tank Farm batches, and volumes and concentrations of solutions in process equipment before startup. The boundary conditions are the physical limits of the flowsheet design, such as piping, volumes, flowrates, operation efficiencies, and physical and chemical environments that impact separations, phase equilibriums, and reaction extents. The operating logic represents the rules and strategies of running the plant.

Protocol for collecting eDNA samples from streams [Version 2.3

Science.gov (United States)

K. J. Carim; T. Wilcox; M. K. Young; K. S. McKelvey; M. K. Schwartz

2015-01-01

Throughout the 2014 field season, we had over two dozen biologist throughout the western US collect over 300 samples for eDNA analysis with paired controls. Control samples were collected by filtering 0.5 L of distilled water. No samples had any evidence of field contamination. This method of sampling verifies the cleanliness of the field equipment, as well as the...

46 CFR 308.517 - Open Cargo Policy, Form MA-300.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Open Cargo Policy, Form MA-300. 308.517 Section 308.517... Risk Cargo Insurance Ii-Open Policy War Risk Cargo Insurance § 308.517 Open Cargo Policy, Form MA-300. The standard form of War Risk Open Cargo, Form MA-300, may be obtained from the American War Risk...

[Comparison study on sampling methods of Oncomelania hupensis snail survey in marshland schistosomiasis epidemic areas in China].

Science.gov (United States)

An, Zhao; Wen-Xin, Zhang; Zhong, Yao; Yu-Kuan, Ma; Qing, Liu; Hou-Lang, Duan; Yi-di, Shang

2016-06-29

To optimize and simplify the survey method of Oncomelania hupensis snail in marshland endemic region of schistosomiasis and increase the precision, efficiency and economy of the snail survey. A quadrate experimental field was selected as the subject of 50 m×50 m size in Chayegang marshland near Henghu farm in the Poyang Lake region and a whole-covered method was adopted to survey the snails. The simple random sampling, systematic sampling and stratified random sampling methods were applied to calculate the minimum sample size, relative sampling error and absolute sampling error. The minimum sample sizes of the simple random sampling, systematic sampling and stratified random sampling methods were 300, 300 and 225, respectively. The relative sampling errors of three methods were all less than 15%. The absolute sampling errors were 0.221 7, 0.302 4 and 0.047 8, respectively. The spatial stratified sampling with altitude as the stratum variable is an efficient approach of lower cost and higher precision for the snail survey.

Reduced CD300LG mRNA tissue expression, increased intramyocellular lipid content and impaired glucose metabolism in healthy male carriers of Arg82Cys in CD300LG

DEFF Research Database (Denmark)

Støy, Julie; Kampmann, Ulla; Mengel, Annette

2015-01-01

BACKGROUND: CD300LG rs72836561 (c.313C>T, p.Arg82Cys) has in genetic-epidemiological studies been associated with the lipoprotein abnormalities of the metabolic syndrome. CD300LG belongs to the CD300-family of membrane-bound molecules which have the ability to recognize and interact with extracel......BACKGROUND: CD300LG rs72836561 (c.313C>T, p.Arg82Cys) has in genetic-epidemiological studies been associated with the lipoprotein abnormalities of the metabolic syndrome. CD300LG belongs to the CD300-family of membrane-bound molecules which have the ability to recognize and interact...... with extracellular lipids. We tested whether this specific polymorphism results in abnormal lipid accumulation in skeletal muscle and liver and other indices of metabolic dysfunction. METHODS: 40 healthy men with a mean age of 55 years were characterized metabolically including assessment of insulin sensitivity...

10 CFR 300.1 - General.

Science.gov (United States)

2010-01-01

... CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.1 General. (a) Purpose... Policy Act of 1992 (42 U.S.C. 13385(b)). The purpose of the guidelines is to establish the procedures and... organizations, households and other private and public entities to submit annual reports of their greenhouse gas...

Electrical resistivity anisotropy of osmium single crystals in the range 4,2 to 300 K

International Nuclear Information System (INIS)

Volkenshtejn, N.V.; Dyakina, V.P.; Dyakin, V.V.; Startsev, V.E.; Cherepanov, V.I.; Azhazha, V.M.; Kovtun, G.P.; Elenskij, V.A.; AN Ukrainskoj SSR, Kharkov. Fiziko-Tekhnicheskij Inst.)

1981-01-01

Electrical resistivity and size effect anisotropies of pure osmium single crystals with rhosub(273.2/rhosub(4.2)2600 were investigated in the temperature range 4.2 to 300 K. It is found that the electrical resistivity anisotropy (αT)=rhosub( )/rhosub( ) is less than unit and has a maximum at T approximately 50 K; the size effect anisotropy (rho1)sub( )/(rho1)sub( ) is 0.39+-0.07 at T=4.2 K; at liquid helium temperature, the dependence of thin samples is controlled by the scattering of conduction electrons by the surface of the sample. The results are discussed for the specific shape of the Fermi surface geometry of osmium with an account for the scattering processes of conduction electrons by phonons and by surface of the sample

41 CFR 301-73.300 - What is a travel payment system?

Science.gov (United States)

2010-07-01

... System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 73-TRAVEL PROGRAMS Travel Payment System § 301-73.300 What is a travel payment system? A system to facilitate the payment of official... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is a travel payment...

Performance in a 12-hour, 300-rad profile

International Nuclear Information System (INIS)

Yochmowitz, M.G.; Brown, G.C.

1977-01-01

A discrete behavioral task was initiated to study the effects of a 300-rad variable dose rate exposure profile upon positively (food reward) and negatively (mild shock) reinforced groups of primates. Animals performed the task for 12 h. Performance decrements were readily apparent in 2 of 8 shock and 2 of 7 food animals, while delayed reaction times were found in 3 of 8 shock and 3 of 7 food animals. Of the 7 food animals, 4 exhibited emesis, while 1 of 8 shock animals vomited. Such information is useful to military planners who need guidelines to indicate potential aircrew nuclear vulnerability and survivability

Two distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) with the same USA300 pulsed-field gel electrophoresis profile: a potential pitfall for identification of USA300 community-associated MRSA

DEFF Research Database (Denmark)

Larsen, Anders Rhod; Goering, Richard; Stegger, Marc

2009-01-01

Analysis of methicillin-resistant Staphylococcus aureus (MRSA) characterized as USA300 by pulsed-field gel electrophoresis identified two distinct clones. One was similar to community-associated USA300 MRSA (ST8-IVa, t008, and Panton-Valentine leukocidin positive). The second (ST8-IVa, t024...

Irantsam pokazali otvet "300 spartantsam"

Index Scriptorium Estoniae

2007-01-01

Ajaloohõnguline sõjafilm "300", mis kujutas Termopüülides 5. saj. e.m.a.pärslaste ja spartalaste vahel toimunud lahingut: režissöör Zack Snyder : Ameerika Ühendriigid 2006. Film kutsus Iraanis esile meelepaha. Loodi dokfilm tõestamaks pärslaste kõrget kultuuritaset filmis kujutatud ajal

300 area solvent evaporator interim status closure plan: Revision 2

International Nuclear Information System (INIS)

1989-02-01

This document describes activities for the closure of a hazardous waste tank treatment facility operated by the US Department of Energy-Richland Operations Office (DOE-RL) and co-operated by the Westinghouse Hanford Company (WHC). This treatment facility was a solvent evaporator located in the 300 Area of the Hanford Site, from 1975 to 1985 on behalf of DOE-RL. The 300 Area Solvent Evaporator (300 ASE) was a modified load lugger (dumpster) in which solvent wastes were evaporated. Some of the solvents were radioactively contaminated because they came from a degreaser which processed bare uranium metal billets from the N Reactor Fuel Manufacturing Facility. The waste was composed of perchloroethylene, trichloroethylene, 1,1,1-trichloroethane, ethyl acetate/bromine solution, paint shop solvents and possibly some used oil. Also, small amounts of uranium, copper, zirconium and possibly beryllium were present in the degreaser solvents as particulates. Radioactive and non-radioactive solvents were not segregated in the 300 ASE, and the entire mixture was regarded as mixed waste

LLNL Experimental Test Site (Site 300) Potable Water System Operations Plan

Energy Technology Data Exchange (ETDEWEB)

Ocampo, R. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Bellah, W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

2015-09-14

The existing Lawrence Livermore National Laboratory (LLNL) Site 300 drinking water system operation schematic is shown in Figures 1 and 2 below. The sources of water are from two Site 300 wells (Well #18 and Well #20) and San Francisco Public Utilities Commission (SFPUC) Hetch-Hetchy water through the Thomas shaft pumping station. Currently, Well #20 with 300 gallons per minute (gpm) pump capacity is the primary source of well water used during the months of September through July, while Well #18 with 225 gpm pump capacity is the source of well water for the month of August. The well water is chlorinated using sodium hypochlorite to provide required residual chlorine throughout Site 300. Well water chlorination is covered in the Lawrence Livermore National Laboratory Experimental Test Site (Site 300) Chlorination Plan (“the Chlorination Plan”; LLNL-TR-642903; current version dated August 2013). The third source of water is the SFPUC Hetch-Hetchy Water System through the Thomas shaft facility with a 150 gpm pump capacity. At the Thomas shaft station the pumped water is treated through SFPUC-owned and operated ultraviolet (UV) reactor disinfection units on its way to Site 300. The Thomas Shaft Hetch- Hetchy water line is connected to the Site 300 water system through the line common to Well pumps #18 and #20 at valve box #1.

Thermal capacity of ternary oxide YBa[sub 2]Cu[sub 3]O[sub 7-y] in 300-1100 K interval. Teploemkost' trojnogo oksida YBa[sub 2]Cu[sub 3]O[sub 7-y] v intervale 300-1100 K

Energy Technology Data Exchange (ETDEWEB)

Sharpataya, G A; Ozerova, Z P; Kolnovalova, I A; Lazarev, V B; Shaplygin, I S [AN SSSR, Moscow (Russian Federation). Inst. Obshchej i Neorganicheskoj Khimii

1991-08-01

Thermal capacity of YBa[sub 2]Cu[sub 3]O[sub 7-y] samples with different thermal prehistory is measured using a differential scanning calorimeter within 300-1100 K interval. It is shown that the combination of thermal capacity temperature dependence curves in these samples demonstrates reversibility and temperature limits of oxygen absorption and release processes with the corresponding changes of the formular index by oxygen from 6.85-6.90 to 6.35 and vice versa. Thermal capacity anomaly, corresponding to the reversible structural transition from orthorhombic to tetragonal phase with the simultaneous oxygen loss is observed within 630-1000 K interval.

A low-temperature (4-300K) constant volume gas thermometer

International Nuclear Information System (INIS)

Combarieu, A. de

1976-01-01

A constant volume gas thermometer was built to calibrate the various secondary thermometers used at low temperature. This gas thermometer is placed in a cryostat where any stable temperature between 4 and 300K may be obtained. The principle is outlined, then the gas thermometer and its auxiliary equipment are briefly described; the corrections to be applied to the results are given and a table shows the values obtained [fr

Solvent Hold Tank Sample Results for MCU-16-991-992-993: July 2016 Monthly sample and MCU-16-1033-1034-1035: July 2016 Superwashed Sample

Energy Technology Data Exchange (ETDEWEB)

Fondeur, F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jones, D. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2016-11-25

SRNL received one set of SHT samples (MCU-16-991, MCU-16-992 and MCU-16-993), pulled on 07/13/2016 and another set of SHT samples (MCU-16-1033, MCU-16-1034, and MCU-16-1035) that were pulled on 07/24/2016 after the solvent was superwashed with 300 mM sodium hydroxide for analysis. Samples MCU-16-991, MCU-16-992, and MCU-16-993 were combined into one sample (MCU-16-991-992-993) and samples MCU-16-1033, MCU-16-1034, and MCU-16-1035 were combined into one sample (MCU-16-1033-1034-1035). Of the two composite samples MCU-16-1033-1034-1035 represents the current chemical state of the solvent at MCU. All analytical conclusions are based on the chemical analysis of MCU-16-1033-1034-1035. There were no chemical differences between MCU-16- 991-992-993 and superwashed MCU-16-1033-1034-1035.

Site 300 Bat Monitoring Final Report

Energy Technology Data Exchange (ETDEWEB)

Drennan, Joe [Garcia and Associates, San Francisco, CA (United States); Tortosa, Justin [Garcia and Associates, San Francisco, CA (United States)

2016-07-18

From June 15 to 18, 2015, GANDA biologist Graham Neale assisted in programming and fieldtesting of the bat monitoring equipment. The equipment was deployed in the field on a meteorological (MET) tower within Site 300 on June 18, 2015.

P300 change and cognitive behavioral therapy in subjects with Internet addiction disorder A 3-month follow-up study

Institute of Scientific and Technical Information of China (English)

Ling Ge; Xiuchun Ge; Yong Xu; Kerang Zhang; Jing Zhao; Xin Kong

2011-01-01

Event-related potential studies of cognitive function in addiction behaviors have focused on the P300 event-related potential component. The current study investigated the association between P300 component and Internet addiction disorder. We found that individuals with Internet addiction disorder exhibited significantly longer P300 latencies than controls (N2: P = 0.035; P3a: P = 0.031; P3b: P = 0.043) and similar P300 amplitudes compared to control participants. After 3 months of cognitive behavioral therapy, P300 latencies decreased significantly in the P3a and P3b (P3a: P = 0.045; P3b: P = 0.062). These results suggest that deficits in cognitive function may be involved in Internet addiction disorder, and that clinical psychological treatment may be effective.

11 CFR 300.2 - Definitions.

Science.gov (United States)

2010-01-01

... donations to, an organization that is described in 26 U.S.C 501(c) and exempt from taxation under 26 U.S.C... any donations to, an organization that is described in 26 U.S.C. 501(c) and exempt from taxation under...) Donation. For purposes of part 300, donation means a payment, gift, subscription, loan, advance, deposit...

Hepatic and vascular enhancement at dual-phase helical CT: comparison of Iobitridol 300 and Iohexol 300 in a prospective randomized study

International Nuclear Information System (INIS)

Legmann, P.; Vignaux, O.; Bahurel, H.; Oudjit, A.; Coste, J.

2001-01-01

The purpose of this study was to determine hepatic and vascular enhancement, clinical tolerance, and iconographic quality of Iobitridol (300 mg/ml) at dual-phase helical CT and to compare it with Iohexol (300 mg/ml). One hundred forty-six patients were randomly divided into two groups. Each group received 120 ml of Iohexol (group A) or Iobitridol (group B). Mean enhancement of liver, aorta and portal vein was obtained at the arterial phase and at the portal-venous phase. Overall image quality was assessed by two independent blinded investigators. Adverse reactions were recorded. There were no significant differences in demographic characteristics and distribution of patient intrinsic parameters between the two groups, except for blood pressure but without statistical correlation between the difference in blood pressure and the impact on enhancement measurements. There was no significant difference in clinical tolerance and image quality. Mean liver as well as aortic and portal vein enhancement measurements did not show any significant difference. Iobitridol compares favorably with Iohexol. Both products have similar safety, tolerance, and efficacy. Both contrast media have equivalent blood pool concentration and interstitial compartment diffusion. (orig.)

Hepatic and vascular enhancement at dual-phase helical CT: comparison of Iobitridol 300 and Iohexol 300 in a prospective randomized study

Energy Technology Data Exchange (ETDEWEB)

Legmann, P.; Vignaux, O.; Bahurel, H.; Oudjit, A. [Dept. of Radiology, Universite Rene Descartes, Paris (France); Coste, J. [Dept. of Biostatistics and Epidemiology, Universite Rene Descartes, Paris (France)

2001-11-01

The purpose of this study was to determine hepatic and vascular enhancement, clinical tolerance, and iconographic quality of Iobitridol (300 mg/ml) at dual-phase helical CT and to compare it with Iohexol (300 mg/ml). One hundred forty-six patients were randomly divided into two groups. Each group received 120 ml of Iohexol (group A) or Iobitridol (group B). Mean enhancement of liver, aorta and portal vein was obtained at the arterial phase and at the portal-venous phase. Overall image quality was assessed by two independent blinded investigators. Adverse reactions were recorded. There were no significant differences in demographic characteristics and distribution of patient intrinsic parameters between the two groups, except for blood pressure but without statistical correlation between the difference in blood pressure and the impact on enhancement measurements. There was no significant difference in clinical tolerance and image quality. Mean liver as well as aortic and portal vein enhancement measurements did not show any significant difference. Iobitridol compares favorably with Iohexol. Both products have similar safety, tolerance, and efficacy. Both contrast media have equivalent blood pool concentration and interstitial compartment diffusion. (orig.)

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

Energy Technology Data Exchange (ETDEWEB)

Lasko, Loren M.; Jakob, Clarissa G.; Edalji, Rohinton P.; Qiu, Wei; Montgomery, Debra; Digiammarino, Enrico L.; Hansen, T. Matt; Risi, Roberto M.; Frey, Robin; Manaves, Vlasios; Shaw, Bailin; Algire, Mikkel; Hessler, Paul; Lam, Lloyd T.; Uziel, Tamar; Faivre, Emily; Ferguson, Debra; Buchanan, Fritz G.; Martin, Ruth L.; Torrent, Maricel; Chiang, Gary G.; Karukurichi, Kannan; Langston, J. William; Weinert, Brian T.; Choudhary, Chunaram; de Vries, Peter; Van Drie, John H.; McElligott, David; Kesicki, Ed; Marmorstein, Ronen; Sun, Chaohong; Cole, Philip A.; Rosenberg, Saul H.; Michaelides, Michael R.; Lai, Albert; Bromberg, Kenneth D. (AbbVie); (UCopenhagen); (Petra Pharma); (UPENN); (JHU); (Van Drie); (Faraday)

2017-09-27

The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic regulatory mechanism of gene transcription1 and is associated with multiple diseases. Histone deacetylase inhibitors are currently approved to treat certain cancers, but progress on the development of drug-like histone actyltransferase inhibitors has lagged behind2. The histone acetyltransferase paralogues p300 and CREB-binding protein (CBP) are key transcriptional co-activators that are essential for a multitude of cellular processes, and have also been implicated in human pathological conditions (including cancer3). Current inhibitors of the p300 and CBP histone acetyltransferase domains, including natural products4, bi-substrate analogues5 and the widely used small molecule C6466,7, lack potency or selectivity. Here, we describe A-485, a potent, selective and drug-like catalytic inhibitor of p300 and CBP. We present a high resolution (1.95 Å) co-crystal structure of a small molecule bound to the catalytic active site of p300 and demonstrate that A-485 competes with acetyl coenzyme A (acetyl-CoA). A-485 selectively inhibited proliferation in lineage-specific tumour types, including several haematological malignancies and androgen receptor-positive prostate cancer. A-485 inhibited the androgen receptor transcriptional program in both androgen-sensitive and castration-resistant prostate cancer and inhibited tumour growth in a castration-resistant xenograft model. These results demonstrate the feasibility of using small molecule inhibitors to selectively target the catalytic activity of histone acetyltransferases, which may provide effective treatments for transcriptional activator-driven malignancies and diseases.

Psychometric Evaluation of the Thought–Action Fusion Scale in a Large Clinical Sample

Science.gov (United States)

Meyer, Joseph F.; Brown, Timothy A.

2015-01-01

This study examined the psychometric properties of the 19-item Thought–Action Fusion (TAF) Scale, a measure of maladaptive cognitive intrusions, in a large clinical sample (N = 700). An exploratory factor analysis (n = 300) yielded two interpretable factors: TAF Moral (TAF-M) and TAF Likelihood (TAF-L). A confirmatory bifactor analysis was conducted on the second portion of the sample (n = 400) to account for possible sources of item covariance using a general TAF factor (subsuming TAF-M) alongside the TAF-L domain-specific factor. The bifactor model provided an acceptable fit to the sample data. Results indicated that global TAF was more strongly associated with a measure of obsessive-compulsiveness than measures of general worry and depression, and the TAF-L dimension was more strongly related to obsessive-compulsiveness than depression. Overall, results support the bifactor structure of the TAF in a clinical sample and its close relationship to its neighboring obsessive-compulsiveness construct. PMID:22315482

Psychometric evaluation of the thought-action fusion scale in a large clinical sample.

Science.gov (United States)

Meyer, Joseph F; Brown, Timothy A

2013-12-01

This study examined the psychometric properties of the 19-item Thought-Action Fusion (TAF) Scale, a measure of maladaptive cognitive intrusions, in a large clinical sample (N = 700). An exploratory factor analysis (n = 300) yielded two interpretable factors: TAF Moral (TAF-M) and TAF Likelihood (TAF-L). A confirmatory bifactor analysis was conducted on the second portion of the sample (n = 400) to account for possible sources of item covariance using a general TAF factor (subsuming TAF-M) alongside the TAF-L domain-specific factor. The bifactor model provided an acceptable fit to the sample data. Results indicated that global TAF was more strongly associated with a measure of obsessive-compulsiveness than measures of general worry and depression, and the TAF-L dimension was more strongly related to obsessive-compulsiveness than depression. Overall, results support the bifactor structure of the TAF in a clinical sample and its close relationship to its neighboring obsessive-compulsiveness construct.

p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

Directory of Open Access Journals (Sweden)

Weilei Yao

2018-01-01

Full Text Available The overwhelming frequency of metabolic diseases such as obesity and diabetes are closely related to liver diseases, which might share common pathogenic signaling processes. These metabolic disorders in the presence of inflammatory response seem to be triggered by and to reside in the liver, which is the central metabolic organ that plays primary roles in regulating lipid and glucose homeostasis upon alterations of metabolic conditions. Recently, abundant emerging researches suggested that p300 and CREB binding protein (CBP are crucial regulators of energy homeostasis and liver fibrosis through both their acetyltransferase activities and transcriptional coactivators. Plenty of recent findings demonstrated the potential roles of p300/CBP in mammalian metabolic homeostasis in response to nutrients. This review is focused on the different targets and functions of p300/CBP in physiological and pathological processes, including lipogenesis, lipid export, gluconeogenesis, and liver fibrosis, also provided some nutrients as the regulator of p300/CBP for nutritional therapeutic approaches to treat liver diseases.

7 CFR 900.300 - General.

Science.gov (United States)

2010-01-01

... Conduct of Referenda To Determine Producer Approval of Milk Marketing Orders To Be Made Effective Pursuant to Agricultural Marketing Agreement Act of 1937, as Amended § 900.300 General. Unless otherwise... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements...

9 CFR 317.300 - Nutrition labeling of meat or meat food products.

Science.gov (United States)

2010-01-01

... Labeling § 317.300 Nutrition labeling of meat or meat food products. (a) Nutrition labeling shall be... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Nutrition labeling of meat or meat food products. 317.300 Section 317.300 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE...

34 CFR 300.129 - State responsibility regarding children in private schools.

Science.gov (United States)

2010-07-01

... schools. 300.129 Section 300.129 Education Regulations of the Offices of the Department of Education... STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Children in Private Schools § 300.129 State responsibility regarding children in private schools. The State must have in effect...

50 CFR 300.42 - Findings leading to removal from fishing area.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Findings leading to removal from fishing area. 300.42 Section 300.42 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.42 Findings leading to removal from...

33 CFR 101.300 - Preparedness communications.

Science.gov (United States)

2010-07-01

... MARITIME SECURITY MARITIME SECURITY: GENERAL Communication (Port-Facility-Vessel) § 101.300 Preparedness... transportation security incident, the COTP will, when appropriate, communicate to the port stakeholders, vessels... risk. (c) Attainment. (1) Each owner or operator of a vessel or facility required to have a security...

Thermal capacity of ternary oxide YBa2Cu3O7-y in 300-1100 K interval

International Nuclear Information System (INIS)

Sharpataya, G.A.; Ozerova, Z.P.; Kolnovalova, I.A.; Lazarev, V.B.; Shaplygin, I.S.

1991-01-01

Thermal capacity of YBa 2 Cu 3 O 7-y samples with different thermal prehistory is measured using a differential scanning calorimeter within 300-1100 K interval. It is shown that the combination of thermal capacity temperature dependence curves in these samples demonstrates reversibility and temperature limits of oxygen absorption and release processes with the corresponding changes of the formular index by oxygen from 6.85-6.90 to 6.35 and vice versa. Thermal capacity anomaly, corresponding to the reversible structural transition from orthorhombic to tetragonal phase with the simultaneous oxygen loss is observed within 630-1000 K interval

40 CFR 180.300 - Ethephon; tolerances for residues.

Science.gov (United States)

2010-07-01

... 1.0 Hog, meat 0.02 Hog, meat byproducts, except kidney 0.2 Horse, fat 0.02 Horse, kidney 1.0 Horse, meat 0.02 Horse, meat byproducts, except kidney 0.2 Milk 0.01 Nut, macadamia 0.5 Pepper 30.0 Pineapple... Blackberry 30.0 Blueberry 20.0 Cantaloupe 2.0 Cattle, fat 0.02 Cattle, kidney 1.0 Cattle, meat 0.02 Cattle...

Safety and risk assessments for the SNR 300

International Nuclear Information System (INIS)

Maschek, W.; Froehlich, R.; Jacobs, H.; Schikorr, M.; Heusener, G.; Caldarola, L.; Royl, P.; Struwe, D.

1983-01-01

Under the official inquiry ''Future Nuclear Energy Policies'', KfK have carried out a number of studies concerning the hazards arising from core-destructive accidents at the SNR-300 reactor. Among these, there was the so-called ''Upper Limit Study'' providing a critical evaluation of literature on all research done on core-destructive accidents (Bethe-Tait excursion) with a high mechanic energy release potential; the other one was the so-called ''SAI Study'' (a cooperation of KfK, Science Applications, Inc. (SAI) and Interatom (IA)) which investigated the hazards of an uncontrolled coolant flow rate disturbance occurring in the SNR-300 reactor. KfK also took part in the analysis of hazards comparing the SNR-300 reactor with an LWR-type reactor like the one at Biblis B, ordered by the Federal Ministry of Research and Technology (BMFT). These studies have already been dealt with KfK-Nachrichten, 14th annual set issue 4/1982. The article on hand summarizes and evaluates once more the most important results. (orig./RW) [de

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy`s (DOE`s) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement.

Phase I remedial investigation report for the 300-FF-5 operable unit, Volume 1

International Nuclear Information System (INIS)

1994-01-01

The focus of this remedial investigation (RI) is the 300-FF-5 operable unit, one of five operable units associated with the 300 Area aggregate of the U.S. Department of Energy's (DOE's) Hanford Site. The 300-FF-5 operable unit is a groundwater operable unit beneath the 300-FF-1, 300-FF-2, and 300-FF-3 source operable units. This operable unit was designated to include all contamination detected in the groundwater and sediments below the water table that emanates from the 300-FF-1, 300-FF-2, and 300-FF-3 operable units (DOE-RL 1990a). In November 1989, the U.S. Environmental Protection Agency (EPA) placed the 300 Area on the National Priorities List (NPL) contained within Appendix B of the National Oil and Hazardous Substance Pollution Contingency Plan (NCP, 53 FR 51391 et seq.). The EPA took this action pursuant to their authority under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA, 42 USC 9601 et seq.). The DOE Richland Operations Office (DOE-RL), the EPA and Washington Department of Ecology (Ecology) issued the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement), in May 1989 (Ecology et al. 1992, Rev. 2). This agreement, among other matters, governs all CERCLA efforts at the Hanford Site. In June 1990, a remedial investigation/feasibility study (RI/FS) workplan for the 300-FF-5 operable unit was issued pursuant to the Tri-Party Agreement

Influence of the mechanical sample treatment on the thermally stimulated exoelectron emission in aspect of the application for sample dating

International Nuclear Information System (INIS)

Zastawny, Andrzej; Bialon, Jan

1999-01-01

The examination was focused on a typical, contemporary produced ceramics, irradiated by the beta particles 90 Sr- 90 Y source. According to measurements, the mechanical treatment of the sample in the form of abrading and washing in alcohol did not affect the glow curve of the TSEE above the temperature 130 deg. C. Because the peaks of the TSEE, which can be taken full advantage for the dating must lie above 300 deg. C, the mechanical and washing preparing of the samples should not affect the measurements

300 Area process sewer piping upgrade and 300 Area treated effluent disposal facility discharge to the City of Richland Sewage System, Hanford Site, Richland, Washington

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-05-01

The U.S. Department of Energy (DOE) is proposing to upgrade the existing 300 Area Process Sewer System by constructing and operating a new process sewer collection system that would discharge to the 300 Area Treated Effluent Disposal Facility. The DOE is also considering the construction of a tie-line from the TEDF to the 300 Area Sanitary Sewer for discharging the process wastewater to the City of Richland Sewage System. The proposed action is needed because the integrity of the old piping in the existing 300 Area Process Sewer System is questionable and effluents might be entering the soil column from leaking pipes. In addition, the DOE has identified a need to reduce anticipated operating costs at the new TEDF. The 300 Area Process Sewer Piping Upgrade (Project L-070) is estimated to cost approximately $9.9 million. The proposed work would involve the construction and operation of a new process sewer collection system. The new system would discharge the effluents to a collection sump and lift station for the TEDF. The TEDF is designed to treat and discharge the process effluent to the Columbia River. The process waste liquid effluent is currently well below the DOE requirements for radiological secondary containment and is not considered a RCRA hazardous waste or a State of Washington Hazardous Waste Management Act dangerous waste. A National Pollutant Discharge Elimination, System (NPDES) permit has been obtained from the U.S. Environmental Protection Agency for discharge to the Columbia River. The proposed action would upgrade the existing 300 Area Process Sewer System by the construction and operation of a new combined gravity, vacuum, and pressurized process sewer collection system consisting of vacuum collection sumps, pressure pump stations, and buried polyvinyl chloride or similar pipe. Two buildings would also be built to house a main collection station and a satellite collection station.

An ultrahigh-vacuum apparatus for resonant diffraction experiments using soft x rays (hν=300-2000 eV)

International Nuclear Information System (INIS)

Takeuchi, T.; Chainani, A.; Takata, Y.; Tanaka, Y.; Oura, M.; Tsubota, M.; Senba, Y.; Ohashi, H.; Mochiku, T.; Hirata, K.; Shin, S.

2009-01-01

We have developed an ultrahigh-vacuum instrument for resonant diffraction experiments using polarized soft x rays in the energy range of hν=300-2000 eV at beamline BL17SU of SPring-8. The diffractometer consists of modified differentially pumped rotary feedthroughs for θ-2θ stages, a sample manipulator with motor-controlled x-y-z-, tilt (χ)-, and azimuth (φ)-axes, and a liquid helium flow-type cryostat for temperature dependent measurements between 30 and 300 K. Test results indicate that the diffractometer exhibits high reproducibility (better than 0.001 deg.) for a Bragg reflection of α-quartz 100 at a photon energy of hν=1950 eV. Typical off- and on-resonance Bragg reflections in the energy range of 530-1950 eV could be measured using the apparatus. The results show that x-ray diffraction experiments with energy-, azimuth-, and incident photon polarization-dependence can be reliably measured using soft x rays in the energy range of ∼300-2000 eV. The facility can be used for resonant diffraction experiments across the L-edge of transition metals, M-edge of lanthanides, and up to the Si K-edge of materials.

Percutaneous Drainage of 300 Intraperitoneal Abscesses with Long-Term Follow-Up

International Nuclear Information System (INIS)

Akinci, Devrim; Akhan, Okan; Ozmen, Mustafa N.; Karabulut, Nevzat; Ozkan, Orhan; Cil, Barbaros E.; Karcaaltincaba, Musturay

2005-01-01

The purpose of the study was to evaluate the efficacy of percutaneous drainage of intraperitoneal abscesses with attention to recurrence and failure rates. A retrospective analysis of percutaneous treatment of 300 intraperitoneal abscesses in 255 patients (147 male, 108 female; average age: 38 years; range: 40 days to 90 years) for whom at least 1-year follow-up data were available was performed. Abscesses were drained with fluoroscopic, sonographic, or computed tomographic guidance. Nine abscesses were drained by simple aspiration; catheter drainage either by Seldinger or trocar technique was used in the remaining 291 abscesses with 6F to 14 F catheters. Initial cure and failure rates were 68% (203/300) and 12% (36/300), respectively. Sixty-one abscesses (20%) were either palliated or temporized. The recurrence rate was 4% (12/300) and nine of them were cured by recatheterization, whereas three of them were treated by medication or surgery. The overall success and failure rates were 91% (273/300) and 9% (27/300), respectively, with temporized, palliated, and recatheterized recurred abscesses. The 30-day mortality rate was 3.1% (8/255). The mean duration of catheterization was 13 days. Intraperitoneal abscesses with safe access routes should be drained percutaneously because of high success and low morbidity, mortality, and recurrence rates

41 CFR 101-39.300 - General.

Science.gov (United States)

2010-07-01

... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.3-Use and Care of GSA Interagency Fleet Management System Vehicles § 101-39.300 General. (a) The objective of the General Services Administration (GSA) Interagency Fleet Management System...

Range Expansion and the Origin of USA300 North American Epidemic Methicillin-Resistant Staphylococcus aureus

Directory of Open Access Journals (Sweden)

Lavanya Challagundla

2018-01-01

Full Text Available The USA300 North American epidemic (USA300-NAE clone of methicillin-resistant Staphylococcus aureus has caused a wave of severe skin and soft tissue infections in the United States since it emerged in the early 2000s, but its geographic origin is obscure. Here we use the population genomic signatures expected from the serial founder effects of a geographic range expansion to infer the origin of USA300-NAE and identify polymorphisms associated with its spread. Genome sequences from 357 isolates from 22 U.S. states and territories and seven other countries are compared. We observe two significant signatures of range expansion, including decreases in genetic diversity and increases in derived allele frequency with geographic distance from the Pennsylvania region. These signatures account for approximately half of the core nucleotide variation of this clone, occur genome wide, and are robust to heterogeneity in temporal sampling of isolates, human population density, and recombination detection methods. The potential for positive selection of a gyrA fluoroquinolone resistance allele and several intergenic regions, along with a 2.4 times higher recombination rate in a resistant subclade, is noted. These results are the first to show a pattern of genetic variation that is consistent with a range expansion of an epidemic bacterial clone, and they highlight a rarely considered but potentially common mechanism by which genetic drift may profoundly influence bacterial genetic variation.

Correlação do potencial evocado P300 com aspectos cognitivos e depressivos do envelhecimento Correlation of the P300 evoked potential in depressive and cognitive aspects of aging

Directory of Open Access Journals (Sweden)

Elisiane Crestani de Miranda

2012-10-01

Full Text Available O P300 é um potencial evocado auditivo de longa latência dependente das habilidades cognitivas. Acredita-se que alterações cognitivas decorrentes ou não por sintomas depressivos possam interferir no P300. OBJETIVO: Verificar a influência do envelhecimento, dos aspectos cognitivos e depressivos na latência do P300 em idosos. MÉTODO: Estudo clínico e experimental com 60 idosos com perda auditiva neurossensorial de grau leve a moderadamente grave, sendo 20 do sexo masculino e 40 feminino e idade média de 71,1 anos. Os participantes realizaram o potencial evocado auditivo de longa latência, no qual foi estudada a latência do P300 (milissegundos. Os aspectos cognitivos foram avaliados por meio do Miniexame do Estado Mental (MEEM e Escala de Avaliação da Doença de Alzheimer (ADAS-Cog. Na avaliação da sintomatologia depressiva, foi aplicada a Escala de Depressão Geriátrica (EDG-15. RESULTADOS: Observou-se uma correlação positiva significante entre a Latência e Idade (p = 0,031. Entretanto, não houve diferença significante entre a latência do P300 e as categorias do ADAS-Cog (p = 0,584, MEEM (p = 0,199 e EDG (p = 0,541. CONCLUSÃO:O avanço da idade ocasionou um aumento da latência do P300, porém, o desempenho cognitivo e a presença de sintomatologia depressiva não influenciaram os resultados do P300 nesta população de idosos.The P300 is a long-latency auditory evoked potential highly dependent on cognitive skills. It is believed that cognitive changes caused or not by depressive symptoms may interfere with the P300. AIM: To investigate the influence of aging, cognitive and depression aspects of the P300 latency in elderly people. METHODS: Clinical and experimental study with 60 elderly patients with sensorineural hearing loss of mild to moderately severe level, 20 males and 40 females, average age of 71.1. Participants were submitted to the long latency auditory evoked potential, in which the P300 latency (milliseconds

Design and development of gas turbine high temperature reactor 300

International Nuclear Information System (INIS)

Kunitomi, Kazuhiko; Katanishi, Shoji; Takada, Shoji; Yan, Xing; Takizuka, Takakazu

2003-01-01

JAERI (Japan Atomic Energy Research Institute) has been designing a Japan's original gas turbine high temperature reactor, GTHTR300 (Gas Turbine High Temperature Reactor 300). The greatly simplified design based on salient features of the HTGR (High Temperature Gas-cooled reactor) with a closed helium gas turbine enables the GTHTR300 a high efficient and economically competitive reactor to be deployed in early 2010s. Also, the GTHTR300 fully taking advantage of various experiences accumulated in design, construction and operation of the HTTR (High Temperature Engineering Test Reactor) and fossil gas turbine systems reduces technological development concerning a reactor system and electric generation system. Original features of this system are core design with two-year refueling interval, conventional steel material usage for a reactor pressure vessel, innovative plant flow scheme and horizontally installed gas turbine unit. Due to these salient features, the capital cost of the GTHTR300 is less than a target cost of 200 thousands Yen/kWe, and the electric generation cost is close to a target cost of 4 Yen/kWh. This paper describes the original design features focusing on reactor core design, fuel design, in-core structure design and reactor pressure vessel design except PCU design. Also, R and D for developing the power conversion unit is briefly described. The present study is entrusted from the Ministry of Education, Culture, Sports, Science and Technology of Japan. (author)

A scanning Hall probe microscope for high resolution magnetic imaging down to 300 mK

International Nuclear Information System (INIS)

Khotkevych, V. V.; Bending, S. J.; Milosevic, M. V.

2008-01-01

We present the design, construction, and performance of a low-temperature scanning Hall probe microscope with submicron lateral resolution and a large scanning range. The detachable microscope head is mounted on the cold flange of a commercial 3 He-refrigerator (Oxford Instruments, Heliox VT-50) and operates between room temperature and 300 mK. It is fitted with a three-axis slip-stick nanopositioner that enables precise in situ adjustment of the probe location within a 6x6x7 mm 3 space. The local magnetic induction at the sample surface is mapped with an easily changeable microfabricated Hall probe [typically GsAs/AlGaAs or AlGaAs/InGaAs/GaAs Hall sensors with integrated scanning tunnel microscopy (STM) tunneling tips] and can achieve minimum detectable fields ≥10 mG/Hz 1/2 . The Hall probe is brought into very close proximity to the sample surface by sensing and controlling tunnel currents at the integrated STM tip. The instrument is capable of simultaneous tunneling and Hall signal acquisition in surface-tracking mode. We illustrate the potential of the system with images of superconducting vortices at the surface of a Nb thin film down to 372 mK, and also of labyrinth magnetic-domain patterns of an yttrium iron garnet film captured at room temperature.

41 CFR 300-2.22 - Who is subject to the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Who is subject to the FTR? 300-2.22 Section 300-2.22 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 2-HOW TO USE THE FTR Question & Answer Format § 300-2.22 Who is subject to...

7 CFR 62.300 - Fees and other costs for service.

Science.gov (United States)

2010-01-01

... 7 Agriculture 3 2010-01-01 2010-01-01 false Fees and other costs for service. 62.300 Section 62...) Quality Systems Verification Programs Definitions Charges for Service § 62.300 Fees and other costs for service. Fees and other charges will be levied based on the following provisions: (a) Fees for service...

P300 component of event-related potentials in persons with asperger disorder.

Science.gov (United States)

Iwanami, Akira; Okajima, Yuka; Ota, Haruhisa; Tani, Masayuki; Yamada, Takashi; Yamagata, Bun; Hashimoto, Ryuichiro; Kanai, Chieko; Takashio, Osamu; Inamoto, Atsuko; Ono, Taisei; Takayama, Yukiko; Kato, Nobumasa

2014-10-01

In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.

Risk-oriented analysis on the German prototype fast breeder reactor SNR-300

International Nuclear Information System (INIS)

Bayer, A.; Koeberlein, K.; Gesellschaft fuer Reaktorsicherheit, Garching, Germany)

1984-01-01

On request of a fact-finding committee of the German Federal Parliament, a risk-oriented analysis on the SNR-300, the German prototype fast breeder reactor, has been performed to allow a pragmatic safety comparison of the SNR-300 and a modern light-water reactor. Results of the technical plant analysis have been summarized in seven release categories. Accident consequences have been calculated for the actual site at Kalkar/Rhine. The results indicate that for the SNR-300 both the frequency of major accidents and the consequences of accidents are smaller than for the pressurized-water reactor analyzed in the German Risk Study. This article summarizes the methods and main results of the analysis of the SNR-300

A combined brain-computer interface based on P300 potentials and motion-onset visual evoked potentials.

Science.gov (United States)

Jin, Jing; Allison, Brendan Z; Wang, Xingyu; Neuper, Christa

2012-04-15

Brain-computer interfaces (BCIs) allow users to communicate via brain activity alone. Many BCIs rely on the P300 and other event-related potentials (ERPs) that are elicited when target stimuli flash. Although there have been considerable research exploring ways to improve P300 BCIs, surprisingly little work has focused on new ways to change visual stimuli to elicit more recognizable ERPs. In this paper, we introduce a "combined" BCI based on P300 potentials and motion-onset visual evoked potentials (M-VEPs) and compare it with BCIs based on each simple approach (P300 and M-VEP). Offline data suggested that performance would be best in the combined paradigm. Online tests with adaptive BCIs confirmed that our combined approach is practical in an online BCI, and yielded better performance than the other two approaches (P<0.05) without annoying or overburdening the subject. The highest mean classification accuracy (96%) and practical bit rate (26.7bit/s) were obtained from the combined condition. Copyright © 2012 Elsevier B.V. All rights reserved.

41 CFR 300-2.1 - What formats exist in the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What formats exist in the FTR? 300-2.1 Section 300-2.1 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 2-HOW TO USE THE FTR General § 300-2.1 What formats exist in the FTR? The FTR...

Does the 'P300' speller depend on eye gaze?

Science.gov (United States)

Brunner, P.; Joshi, S.; Briskin, S.; Wolpaw, J. R.; Bischof, H.; Schalk, G.

2010-10-01

Many people affected by debilitating neuromuscular disorders such as amyotrophic lateral sclerosis, brainstem stroke or spinal cord injury are impaired in their ability to, or are even unable to, communicate. A brain-computer interface (BCI) uses brain signals, rather than muscles, to re-establish communication with the outside world. One particular BCI approach is the so-called 'P300 matrix speller' that was first described by Farwell and Donchin (1988 Electroencephalogr. Clin. Neurophysiol. 70 510-23). It has been widely assumed that this method does not depend on the ability to focus on the desired character, because it was thought that it relies primarily on the P300-evoked potential and minimally, if at all, on other EEG features such as the visual-evoked potential (VEP). This issue is highly relevant for the clinical application of this BCI method, because eye movements may be impaired or lost in the relevant user population. This study investigated the extent to which the performance in a 'P300' speller BCI depends on eye gaze. We evaluated the performance of 17 healthy subjects using a 'P300' matrix speller under two conditions. Under one condition ('letter'), the subjects focused their eye gaze on the intended letter, while under the second condition ('center'), the subjects focused their eye gaze on a fixation cross that was located in the center of the matrix. The results show that the performance of the 'P300' matrix speller in normal subjects depends in considerable measure on gaze direction. They thereby disprove a widespread assumption in BCI research, and suggest that this BCI might function more effectively for people who retain some eye-movement control. The applicability of these findings to people with severe neuromuscular disabilities (particularly in eye-movements) remains to be determined.

Characterization and monitoring of 300 Area facility liquid waste streams: 1994 Annual report

International Nuclear Information System (INIS)

Manke, K.L.; Riley, R.G.; Ballinger, M.Y.; Damberg, E.G.; Evans, J.C.; Julya, J.L.; Olsen, K.B.; Ozanich, R.M.; Thompson, C.J.; Vogel, H.R.

1995-04-01

This report summarizes the results of characterizing and monitoring the following sources during calendar year 1994: liquid waste streams from Buildings 306, 320, 324, 326, 331, and 3720 in the 300 Area of Hanford Site and managed by the Pacific Northwest Laboratory; treated and untreated Columbia River water (influent); and water at the confluence of the waste streams (that is, end-of-pipe). Data were collected from March to December before the sampling system installation was completed. Data from this initial part of the program are considered tentative. Samples collected were analyzed for chemicals, radioactivity, and general parameters. In general, the concentrations of chemical and radiological constituents and parameters in building wastewaters which were sampled and analyzed during CY 1994 were similar to historical data. Exceptions were the occasional observances of high concentrations of chloride, nitrate, and sodium that are believed to be associated with excursions that were occurring when the samples were collected. Occasional observances of high concentrations of a few solvents also appeared to be associated with infrequent building r eases. During calendar year 1994, nitrate, aluminum, copper, lead, zinc, bis(2-ethylhexyl) phthalate, and gross beta exceeded US Environmental Protection Agency maximum contaminant levels

Absorption spectrum of DNA for wavelengths greater than 300 nm

International Nuclear Information System (INIS)

Sutherland, J.C.; Griffin, K.P.

1981-01-01

Although DNA absorption at wavelengths greater than 300 nm is much weaker than that at shorter wavelengths, this absorption seems to be responsible for much of the biological damage caused by solar radiation of wavelengths less than 320 nm. Accurate measurement of the absorption spectrum of DNA above 300 nm is complicated by turbidity characteristic of concentrated solutions of DNA. We have measured the absorption spectra of DNA from calf thymus, Clostridium perfringens, Escherichia coli, Micrococcus luteus, salmon testis, and human placenta using procedures which separate optical density due to true absorption from that due to turbidity. Above 300 nm, the relative absorption of DNA increases as a function of guanine-cytosine content, presumably because the absorption of guanine is much greater than the absorption of adenine at these wavelengths. This result suggests that the photophysical processes which follow absorption of a long-wavelength photon may, on the average, differ from those induced by shorter-wavelength photons. It may also explain the lower quantum yield for the killing of cells by wavelengths above 300 nm compared to that by shorter wavelengths

Improvement of the vibration isolation system for TAMA300

CERN Document Server

Takahashi, R

2002-01-01

The vibration isolation system for TAMA300 has a vibration isolation ratio large enough to achieve the requirement in the observation band around 300 Hz. At a lower frequency range, it is necessary to reduce the large fluctuation of mirrors for stable operation of the interferometer. With this aim, the mirror suspension systems were modified and an active vibration isolation system using pneumatic actuators was installed. These improvements contributed to the realization of a continuous interferometer lock for more than 24 h.

34 CFR 300.149 - SEA responsibility for general supervision.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false SEA responsibility for general supervision. 300.149 Section 300.149 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State...

Spatial Filter Feature Extraction Methods for P300 BCI Speller: A Comparison

DEFF Research Database (Denmark)

Chiou, Eleni; Puthusserypady, Sadasivan

2017-01-01

Brain Computer Interface (BCI) systems enable subjects affected by neuromuscular disorders to interact with the outside world. A P300 speller uses Event Related Potential (ERP) components, generated in the brain in the presence of a target stimulus, to extract information about the user’s intent...

45 CFR 2519.300 - Who may participate in a Higher Education program?

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Who may participate in a Higher Education program... FOR NATIONAL AND COMMUNITY SERVICE HIGHER EDUCATION INNOVATIVE PROGRAMS FOR COMMUNITY SERVICE Participant Eligibility and Benefits § 2519.300 Who may participate in a Higher Education program? Students...

P300 in individuals with sensorineural hearing loss

Directory of Open Access Journals (Sweden)

Ana Cláudia Mirandola Barbosa Reis

2015-04-01

Full Text Available INTRODUCTION: Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention.OBJECTIVE: To study P300 in subjects with severe or profound sensorineural hearing loss.METHODS: This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials.RESULTS: A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97 ms and mean amplitude of 3.76 V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p = 0.04, with the predominant auditory communication channels (p < 0.0001, and with time of hearing loss.CONCLUSIONS: P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome.

Musical rhythms and their influence on P300 velocity in young females.

Science.gov (United States)

Sá, Cintia Ishii de; Pereira, Liliane Desguado

2011-01-01

Exposure to music may be useful in the P300 retest and avoid habituation. To verify the influence of the exposure to different kinds of music in P300 in young females. Clinical prospective. Forty-five women aged from 20 to 36 years were evaluated. P300 was studied before and after musical stimulation with different rhythms. Brazilian songs, international songs, and classical music melodies were selected. Each song had its velocity altered and was named as fast and slow. Subjects were divided into 2 groups exposed to music: one group was exposed to the fast version and the other to the slow version. The control group not exposed to music and was evaluated within the same time period of the others. There were statistically significant differences when comparing P300 amplitude in the first and third stimulation with the comparison group. In the same subject, several sequential registrations of P300 caused habituation, which was not seen during exposure to music before P300 recording. Exposure to music at preset different velocities did not affect the P300 in young females.

14 CFR 300.3 - Reporting of communications.

Science.gov (United States)

2010-01-01

...) Information given at the request of a DOT employee in a tariff matter under § 300.2(c)(6) of this chapter. (4... national defense or foreign policy (including international aviation), shall either: (1) Refer the...

Musical rhythms and their influence on P300 velocity in young females Ritmos musicais diferentes: influência da velocidade no P300 em jovens mulheres

OpenAIRE

Cintia Ishii de Sá; Liliane Desguado Pereira

2011-01-01

Exposure to music may be useful in the P300 retest and avoid habituation. AIM: To verify the influence of the exposure to different kinds of music in P300 in young females. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Forty-five women aged from 20 to 36 years were evaluated. P300 was studied before and after musical stimulation with different rhythms. Brazilian songs, international songs, and classical music melodies were selected. Each song had its velocity altered and was named ...

The SNR-300 steam generator small leak detection system

International Nuclear Information System (INIS)

Dumm, K.

1984-01-01

Small leak detection in the SNR-300 steam generator moduls is achieved by hydrogen meters. Development and design of the Nickel membrane - ion getter pump combination are described and sensitivity requests derived. Results of calibration tests by water/steam injections in a sodium loop are presented. The arrangement and interconnection of signals in SNR-300 are given and possibilities for inservice calibrations are discussed, supported by long time operation tests in the KNK-reactor plant. (author)

40 CFR 300.6 - Use of number and gender.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Use of number and gender. 300.6... PLAN Introduction § 300.6 Use of number and gender. As used in this regulation, words in the singular also include the plural and words in the masculine gender also include the feminine and vice versa, as...

Nuclear criticality safety: 300 Area

International Nuclear Information System (INIS)

1991-01-01

This Standard applies to the receipt, processing, storage, and shipment of fissionable material in the 300 Area and in any other facility under the control of the Reactor Materials Project Management Team (PMT). The objective is to establish practices and process conditions for the storage and handling of fissionable material that prevent the accidental assembly of a critical mass and that comply with DOE Orders as well as accepted industry practice

76 FR 42029 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2011-07-18

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4... A300 B4-605R and B4-622R airplanes, Model A300 F4-605R and F4-622R airplanes, and Model A300 C4- [[Page...

Lower P300 amplitude in eight-year-old offspring of alcoholic fathers with a delinquent history.

Science.gov (United States)

Viana-Wackermann, Paula C; Furtado, Erikson F; Esser, Günter; Schmidt, Martin H; Laucht, Manfred

2007-06-01

The aim of the present study was to investigate the P300 amplitude as a possible vulnerability marker in children of alcoholic (COA) fathers with and without paternal delinquency. Event-related potentials (ERPs) of 122 children aged 8 years (63 boys, 59 girls) were compared depending on father's alcoholism subtype: 30 COAs without paternal delinquency, 10 COAs with paternal delinquency, and 82 children of non-alcoholic and non-delinquent fathers. ERPs were recorded from Fz, Cz, and Pz, using an auditory oddball paradigm. Sinus tones of 60 dB HL were presented binaurally at 1,000 Hz (standard stimulus) and 2,000 Hz (target stimulus), at a relative frequency ratio of 80:20. Two trial blocks of 250 stimuli each were collected. Results indicated that only COAs with paternal delinquency displayed significant differences from the control group, characterized by reduced P300 amplitude at frontal site and in the second trial block. Thus, the combination of fathers' alcoholism and delinquency was more likely to relate to attenuated P300 amplitude in the offspring than paternal alcoholism alone. Our results suggest that both alcoholic and delinquent family history appear to play a role in P300 amplitude reduction in the offspring.

40 CFR 300.605 - State trustees.

Science.gov (United States)

2010-07-01

... PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Trustees for Natural Resources § 300.605 State trustees. State trustees shall act on behalf of the... subpart G of this part, the definition of the term state does not include Indian tribes. The governor of a...

The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines

Directory of Open Access Journals (Sweden)

Mohammad Reza Salahshoor

2013-10-01

Full Text Available Background: P300 is an enzyme that acetylates histones during stress. It alsoacetylates several non-histone proteins, including P53 which is the most important tumorsuppressor gene. P53 plays an important role in the apoptosis of tumor cells. Hereby,this study describes the potency of cholera toxin B subunit as a P300 activator to induceapoptosis in a breast cancer cell line (MCF-7 and a lung fibroblast cell line (MRC-5as a non-tumorigenic control sample. Methods: MCF-7 and MRC-5 were cultured in RPMI-1640 and treated with orwithout cholera toxin B subunit at the concentration of 85.43 μmol/L, based on the half-maximal inhibitory concentration index at different times (24, 48 and 72 h. Thepercentage of apoptotic cells was measured by flow cytometry. Real-time quantitativeRT-PCR was performed to estimate the mRNA expression of P300 in MCF-7 and MRC-5 with cholera toxin B subunit at different times. We used the ELISA and Bradford proteintechniques to detect levels of total and acetylated P53 protein generated in MCF-7 andMRC-5. Results: Our findings indicated that the cholera toxin B subunit effectively andsignificantly induced more apoptosis in MCF-7 compared to MRC-5. We showed thatexpression of P300 up-regulated by increasing the time of the cholera toxin B subunittreatment in MCF-7 but not in MRC-5. In addition, the acetylated and total P53protein levels increased more in MCF-7 cells than in MRC-5 cells.Conclusion: Cholera toxin B subunit induced significant cell death in MCF-7, butit could be well tolerated in MRC-5. Therefore, cholera toxin B subunit can besuggested as an anti-cancer agent.

75 FR 60611 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2010-10-01

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model A300 C4...; Model A300 B4-601, B4- 603, B4-620, B4-622, B4-605R, B4-622R, F4-605R, F4-622R, and C4-605R Variant F...-- Dated-- A300 series airplanes......... A300-32A0447..... April 22, 2004. A300 B4-600, B4-600R, and F4...

P300 in individuals with sensorineural hearing loss.

Science.gov (United States)

Reis, Ana Cláudia Mirandola Barbosa; Frizzo, Ana Claudia Figueiredo; Isaac, Myriam de Lima; Garcia, Cristiane Fregonesi Dutra; Funayama, Carolina Araújo Rodrigues; Iório, Maria Cecília Martinelli

2015-01-01

Behavioral and electrophysiological auditory evaluations contribute to the understanding of the auditory system and of the process of intervention. To study P300 in subjects with severe or profound sensorineural hearing loss. This was a descriptive cross-sectional prospective study. It included 29 individuals of both genders with severe or profound sensorineural hearing loss without other type of disorders, aged 11 to 42 years; all were assessed by behavioral audiological evaluation and auditory evoked potentials. A recording of the P3 wave was obtained in 17 individuals, with a mean latency of 326.97ms and mean amplitude of 3.76V. There were significant differences in latency in relation to age and in amplitude according to degree of hearing loss. There was a statistically significant association of the P300 results with the degrees of hearing loss (p=0.04), with the predominant auditory communication channels (p<0.0001), and with time of hearing loss. P300 can be recorded in individuals with severe and profound congenital sensorineural hearing loss; it may contribute to the understanding of cortical development and is a good predictor of the early intervention outcome. Copyright © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

29 CFR 780.300 - Statutory exemptions in section 13(a)(6).

Science.gov (United States)

2010-07-01

... Employment in Agriculture That Is Exempted From the Minimum Wage and Overtime Pay Requirements Under Section... the Act exempts from the minimum wage requirements of section 6 and from the overtime pay requirements... 780.300 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR...

OGJ300 population shrinks, but assets total grows

International Nuclear Information System (INIS)

Beck, R.J.; Bell, L.

1995-01-01

Publicly traded oil and gas companies in the US are declining in population but growing in financial terms. The Oil and Gas Journal 300, the annual list of publicly traded companies with oil production in the US, includes only 281 companies this year. As of the data compilation deadline, only that number of companies had filed annual financial results with the US Securities and Exchange Commission. The OGJ300 ranks companies by assets without regard to whether the companies use the successful efforts or full cost accounting method. Normally, assets for a given set of properties are higher under full cost than under successful efforts accounting

10 CFR 300.11 - Independent verification.

Science.gov (United States)

2010-01-01

... DEPARTMENT OF ENERGY CLIMATE CHANGE VOLUNTARY GREENHOUSE GAS REPORTING PROGRAM: GENERAL GUIDELINES § 300.11... managing an auditing or verification process, including the recruitment and allocation of other individual.... (c) Qualifications of organizations accrediting verifiers. Organizations that accredit individual...

The P300 in middle cerebral artery strokes or hemorrhages: Outcome predictions and source localization.

Science.gov (United States)

Ehlers, Mana R; López Herrero, Carmen; Kastrup, Andreas; Hildebrandt, Helmut

2015-08-01

There are no reliable outcome predictors for severely impaired patients suffering from large infarctions or hemorrhages within the territory of the middle cerebral artery. This study investigated whether the amplitude of the event-related potential (ERP) component P300 predicts if a patient will be transferred to the next stage of rehabilitation (positive outcome) or to a nursing home (negative outcome). The second goal was to look for lesion locations determining the generation of the P300 amplitude. Forty-seven patients performed an auditory oddball task to elicit the P300 and were assessed with different scores for activities of daily living (ADL). Patients were divided in two groups according to their outcome. P300 amplitudes were compared between these groups controlling for age and gender. Post-hoc analyses were performed to analyse the relationship between P300 amplitude and neurological outcome scores. In addition, lesion overlaps were created to detect which lesion pattern affects P300 generation. Patients with a positive outcome showed higher P300 amplitudes at frontal electrode sites than those with a negative outcome. P300 amplitude correlated with ADL score difference. Lesions in the superior temporal gyrus, middle and inferior frontal and prefrontal regions led to visibly diminished P300 amplitudes. The findings suggest that an impairment of attention (P300 amplitude reduction) negatively influences successful neurological rehabilitation. Left superior temporal lobe and the left premotor/prefrontal areas are essential brain areas for the generation of the P300. P300 amplitude may be used as an outcome predictor for severely impaired patients suffering from middle cerebral artery strokes or hemorrhages. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

FEI Titan G2 60-300 HOLO

Directory of Open Access Journals (Sweden)

Chris Boothroyd

2016-02-01

Full Text Available The FEI Titan G2 60-300 HOLO is a unique fourth generation transmission electron microscope, which has been specifically designed for the investigation of electromagnetic fields of materials using off-axis electron holography. It has a Lorentz lens to allow magnetic field free imaging plus two electron biprisms, which in combination enable more uniform holographic fringes to be used. The instrument also has an ultra-wide objective lens pole piece gap which is ideal for in situ experiments. For these purposes, the FEI Titan G2 60-300 HOLO is equipped with a Schottky type high-brightness electron gun (FEI X-FEG, an image Cs corrector (CEOS, a post-column energy filter system (Gatan Tridiem 865 ER as well as a 4 megapixel CCD system (Gatan UltraScan 1000 XP. Typical examples of use and technical specifications for the instrument are given below.

Electron beam dosimetry for a thin-layer absorber irradiated by 300-keV electrons

International Nuclear Information System (INIS)

Kijima, Toshiyuki; Nakase, Yoshiaki

1993-01-01

Depth-dose distributions in thin-layer absorbers were measured for 300-keV electrons from a scanning-type irradiation system, the electrons having penetrated through a Ti-window and an air gap. Irradiations of stacks of cellulose triacetate(CTA) film were carried out using either a conveyor (i.e. dynamic irradiation) or fixed (i.e. static) irradiation. The sample was irradiated using various angles of incidence of electrons, in order to examine the effect of obliqueness of electron incidence at low-energy representative of routine radiation curing of thin polymeric or resin layers. Dynamic irradiation gives broader and shallower depth-dose distributions than static irradiation. Greater obliqueness of incident electrons gives results that can be explained in terms of broader and shallower depth-dose distributions. The back-scattering of incident electrons by a metal(Sn) backing material enhances the absorbed dose in a polymeric layer and changes the overall distribution. It is suggested that any theoretical estimations of the absorbed dose in thin layers irradiated in electron beam curing must be accomplished and supported by experimental data such as that provided by this investigation. (Author)

Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling.

Directory of Open Access Journals (Sweden)

Xiangsheng Xiao

Full Text Available Quercetin, a polyphenolic bioflavonoid, possesses multiple pharmacological actions including anti-inflammatory and antitumor properties. However, the precise action mechanisms of quercetin remain unclear. Here, we reported the regulatory actions of quercetin on cyclooxygenase-2 (COX-2, an important mediator in inflammation and tumor promotion, and revealed the underlying mechanisms. Quercetin significantly suppressed COX-2 mRNA and protein expression and prostaglandin (PG E(2 production, as well as COX-2 promoter activation in breast cancer cells. Quercetin also significantly inhibited COX-2-mediated angiogenesis in human endothelial cells in a dose-dependent manner. The in vitro streptavidin-agarose pulldown assay and in vivo chromatin immunoprecipitation assay showed that quercetin considerably inhibited the binding of the transactivators CREB2, C-Jun, C/EBPβ and NF-κB and blocked the recruitment of the coactivator p300 to COX-2 promoter. Moreover, quercetin effectively inhibited p300 histone acetyltransferase (HAT activity, thereby attenuating the p300-mediated acetylation of NF-κB. Treatment of cells with p300 HAT inhibitor roscovitine was as effective as quercetin at inhibiting p300 HAT activity. Addition of quercetin to roscovitine-treated cells did not change the roscovitine-induced inhibition of p300 HAT activity. Conversely, gene delivery of constitutively active p300 significantly reversed the quercetin-mediated inhibition of endogenous HAT activity. These results indicate that quercetin suppresses COX-2 expression by inhibiting the p300 signaling and blocking the binding of multiple transactivators to COX-2 promoter. Our findings therefore reveal a novel mechanism of action of quercetin and suggest a potential use for quercetin in the treatment of COX-2-mediated diseases such as breast cancers.

Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

International Nuclear Information System (INIS)

Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku

1993-01-01

To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.)

Cerebral lesions and event-related potential P300 using positron emission tomography (PET)

Energy Technology Data Exchange (ETDEWEB)

Sakai, Yasujiro; Okamoto, Kazuma; Tanaka, Makoto; Kondoh, Susumu; Hirai, Shunsaku (Gunma Univ., Maebashi (Japan). School of Medicine)

1993-06-01

To determine what lesions are involved in prolonging event-related potential P300 latency, regional cerebral blood flow (rCBF) and metabolism were investigated by positron emission tomography (PET) in a total of 40 patients with neurologic diseases (12 with chronic cerebrovascular disorder, 9 with spino-cerebellar degeneration, 4 with Alzheimer's type dementia, 4 with amyotrophic lateral sclerosis, and 11 with miscellaneous diseases). There was inverse correlation between rCBF and P300 latency in terms of any of the whole, left, and right hemispheres: P300 latency was associated with decreased rCBF. This was more noticeable in the cerebral cortex than white matter and in the right than left hemisphere, although there was no significant difference between them. In none of the regions, however, was there significant correlation between cerebral oxygen consumption and P300 latency. When the right and left frontal, temporal, parietal and occipital cortexes, thalamus, putamen, and caudatum were examined as regions of interest, there was significantly inverse correlation between rCBF and P300 latency in all regions except for the occipital cortex. This was more noticeable on the right than the left side, although no significant difference was observed. Cerebral oxygen consumption in these lesions did not correlate with P300 latency. In the study on bilateral rCBF difference, decreased rCBF confined to the right parietal lobe, bilateral thalamus and bilateral temporal lobes was found to be associated with a significantly prolonged P300 latency. Thus, rCBF in these regions seemed to be particularly responsible for P300 latency. (N.K.).

Experimental study of the phase equilibria in the Mg–Zn–Ag ternary system at 300 °C

Energy Technology Data Exchange (ETDEWEB)

Wang, Jian, E-mail: jian.wang@polymtl.ca [Center for Research in Computational Thermochemistry (CRCT), Department of Chemical Engineering, École Polytechnique, Montréal, Québec H3C 3A7 (Canada); Zhang, Yi-Nan [Department of Mechanical Engineering, Concordia University, 1455 De Maisonneuve Blvd. West, Montreal, Quebec H3G 1M8 (Canada); Hudon, Pierre; Jung, In-Ho [Department of Mining and Materials Engineering, McGill University, 3610 University Street, Montreal, Quebec H3A 0C5 (Canada); Medraj, Mamoun [Department of Mechanical Engineering, Concordia University, 1455 De Maisonneuve Blvd. West, Montreal, Quebec H3G 1M8 (Canada); Department of Mechanical and Materials Engineering, Masdar Institute, Masdar City, P.O. Box 54224, Abu Dhabi (United Arab Emirates); Chartrand, Patrice [Center for Research in Computational Thermochemistry (CRCT), Department of Chemical Engineering, École Polytechnique, Montréal, Québec H3C 3A7 (Canada)

2015-08-05

Highlights: • The phase equilibria of Mg–Zn–Ag system at 300 °C were determined. • A bcc continuous ternary solid solution forms between MgAg (bcc-B2) and AgZn (bcc-A2) was determined. • The extended solid solubilities of the sub-binary compounds were also determined. - Abstract: The phase equilibria in the Mg–Zn–Ag ternary system at 300 °C were investigated using three diffusion couples and 35 key samples. Scanning electron microscopy (SEM) equipped with energy-dispersive spectroscope (EDS) and X-ray diffraction (XRD) techniques were used for homogeneity ranges and crystal structure determination. Large solid solubility limits, due to substitution among Mg, Zn and Ag atoms in Mg{sub 3}Ag and MgZn{sub 2} phases, were observed in the present work. Solid solubility limits of Ag and Zn in the hcp (Mg) phase were found to be less than 1 at.%. The extended solid solubilities of the Mg{sub 12}Zn{sub 13}, Mg{sub 2}Zn{sub 3}, MgZn{sub 2} (C14), Mg{sub 2}Zn{sub 11}, Ag{sub 5}Zn{sub 8} and hcp (AgZn{sub 3}) sub-binary compounds were also determined in the Mg–Zn–Ag ternary system. In addition, a bcc continuous ternary solid solution forms between MgAg (bcc-B2) and AgZn (bcc-A2) at 300 °C.

Phosphorylation of the cytoplasmic tail of the 300-kDa mannose 6-phosphate receptor is required for the interaction with a cytosolic protein

DEFF Research Database (Denmark)

Rosorius, O; Issinger, O G; Braulke, T

1993-01-01

The cytoplasmic tail of the human 300-kDa mannose 6-phosphate receptor (MPR 300-CT) is an excellent substrate for casein kinase II in vitro. The phosphorylated MPR 300-CT was cross-linked by means of bis(sulfosuccinimidyl)suberate mainly to a cytosolic protein of 35 kDa (referred to as TIP 35...... with TIP 35 is phosphorylation-specific. Furthermore, TIP 35 was only cross-linked to the MPR 300-CT phosphorylated by casein kinase II whereas the MPR 300-CT phosphorylated by protein kinase A failed to cross-link to TIP 35. These results indicate that the cytoplasmic tail of the MPR 300 interacts...

20 CFR 638.300 - Eligibility for funds and eligible deliverers.

Science.gov (United States)

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Eligibility for funds and eligible deliverers. 638.300 Section 638.300 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Funding, Site Selection...

Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300: a comparative study Efeitos neuromoduladores da cafeína e do bromazepam no potencial evocado visual relacionado a evento (P300: estudo comparativo

Directory of Open Access Journals (Sweden)

Mariana Montenegro

2005-06-01

Full Text Available The P300 component of the event-related potential (ERP is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS to process incoming information. OBJECTIVE: To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300, in relation to a P300 normative database. METHOD: 15 right-handed individuals (7 male and 8 female, between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design. RESULTS: Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database. CONCLUSION: The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.O componente P300 do potencial evocado relacionado a evento é uma medida geral de "eficiência cognitiva" e um índice da qualidade do processamento e armazenamento de informações pelo sistema nervoso central (SNC. OBJETIVO: Comparar os efeitos neuromoduladores da cafeína e do bromazepam a partir do banco normativo do potencial evocado visual (P300. MÉTODO: 15 sujeitos destros (7 homens e 8 mulheres, entre 20 e 30 anos de idade, sadios, livres de qualquer déficit cognitivo e sem uso de substâncias psicotrópicas ou psicoativas foram estudados. Os sujeitos foram submetidos a uma tarefa de discriminação visual utilizando o paradigma "oddball", após a administração de uma cápsula de cafeína ou de bromazepam, em um desenho duplo-cego randomizado. RESULTADOS: Foram observadas diferenças estatisticamente significativas quando as condições cafeína e bromazepam foram comparadas com o banco normativo. CONCLUSÃO: Os resultados sugerem que a cafe

41 CFR 300-1.2 - What is the purpose of the FTR?

Science.gov (United States)

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What is the purpose of the FTR? 300-1.2 Section 300-1.2 Public Contracts and Property Management Federal Travel Regulation System GENERAL INTRODUCTION 1-THE FEDERAL TRAVEL REGULATION (FTR) § 300-1.2 What is the purpose of the...

34 CFR 300.102 - Limitation-exception to FAPE for certain ages.

Science.gov (United States)

2010-07-01

... actually identified as being a child with a disability under § 300.8; and (B) Did not have an IEP under... § 300.8 and had received services in accordance with an IEP, but who left school prior to their incarceration; or (B) Did not have an IEP in their last educational setting, but who had actually been...

34 CFR 300.615 - Records on more than one child.

Science.gov (United States)

2010-07-01

... information on more than one child, the parents of those children have the right to inspect and review only... 34 Education 2 2010-07-01 2010-07-01 false Records on more than one child. 300.615 Section 300.615... CHILDREN WITH DISABILITIES Monitoring, Enforcement, Confidentiality, and Program Information...

Removable samples for ITER—a feasibility and conceptual study

International Nuclear Information System (INIS)

Mertens, Ph; Neubauer, O; Philipps, V; Huber, A; Kirschner, A; Knaup, M; Borodin, D; Samm, U; Ciattaglia, S; Choi, C H; Gicquel, S; Hirai, T; Mitteau, R; Pitts, R A; Sadakov, S; Shimada, M; Veshchev, E

2014-01-01

The control of the radioactive inventory in the vacuum vessel of ITER is a main safety issue. Erosion of activated plasma-facing components (PFC) and co-deposition of tritiated dust on PFC and in areas below the divertor constitute the main sources of in-vessel radioactive inventory mobilizable in the case of an accident and also during venting of the vessel. To trace the dust and tritium inventory in the machine, the use of collectors in the form of removable samples was evaluated, beside other techniques, since it provides a reliable way to follow the history of the deposits and check critical areas. Four types of removable probes and two optional active diagnostics were selected out of about 30 different options. For all four probes, a conceptual design was worked out and the feasibility was checked with preliminary estimations of thermal and electromagnetic loads, as well as remote handling paths. The highest temperature estimated for the front face of all probes lies in the range 300–500 °C, which is tolerable. Installed in representative places, such removable samples may provide information about the dust and tritium distribution inside the vacuum vessel. (paper)

NuSTAR discovery of a cyclotron line in KS 1947+300

DEFF Research Database (Denmark)

Fürst, Felix; Pottschmidt, Katja; Wilms, Jörn

2014-01-01

-resolved spectroscopy reveals that the strength of the feature changes strongly with pulse phase and is most prominent during the broad minimum of the pulse profile. At the same phases the line also becomes visible in the first and third observation at the same energy. This discovery implies that KS 1947+300 has...

Causality in the association between P300 and alpha event-related desynchronization.

Directory of Open Access Journals (Sweden)

Weiwei Peng

Full Text Available Recent findings indicated that both P300 and alpha event-related desynchronization (α-ERD were associated, and similarly involved in cognitive brain functioning, e.g., attention allocation and memory updating. However, an explicit causal influence between the neural generators of P300 and α-ERD has not yet been investigated. In the present study, using an oddball task paradigm, we assessed the task effect (target vs. non-target on P300 and α-ERD elicited by stimuli of four sensory modalities, i.e., audition, vision, somatosensory, and pain, estimated their respective neural generators, and investigated the information flow among their neural generators using time-varying effective connectivity in the target condition. Across sensory modalities, the scalp topographies of P300 and α-ERD were similar and respectively maximal at parietal and occipital regions in the target condition. Source analysis revealed that P300 and α-ERD were mainly generated from posterior cingulate cortex and occipital lobe respectively. As revealed by time-varying effective connectivity, the cortical information was consistently flowed from α-ERD sources to P300 sources in the target condition for all four sensory modalities. All these findings showed that P300 in the target condition is modulated by the changes of α-ERD, which would be useful to explore neural mechanism of cognitive information processing in the human brain.

Computational Modeling in Plasma Processing for 300 mm Wafers

Science.gov (United States)

Meyyappan, Meyya; Arnold, James O. (Technical Monitor)

1997-01-01

Migration toward 300 mm wafer size has been initiated recently due to process economics and to meet future demands for integrated circuits. A major issue facing the semiconductor community at this juncture is development of suitable processing equipment, for example, plasma processing reactors that can accomodate 300 mm wafers. In this Invited Talk, scaling of reactors will be discussed with the aid of computational fluid dynamics results. We have undertaken reactor simulations using CFD with reactor geometry, pressure, and precursor flow rates as parameters in a systematic investigation. These simulations provide guidelines for scaling up in reactor design.

Search for lepton flavor violation in ep collisions at 300 GeV center of mass energy

International Nuclear Information System (INIS)

Derrick, M.; Krakauer, D.; Magill, S.

1996-08-01

Using the ZEUS detector at the HERA electron-proton collider, we have searched for lepton flavor violation in ep collisions at a center-of-mass energy (√s) of 300 GeV. Events of the type e+p→l+X with a final-state lepton of high transverse momentum, l=μ or τ, were sought. No evidence was found for lepton flavor violation in the combined 1993 and 1994 data samples, for which the integrated luminosities were 0.84 pb -1 for e - p collisions and 2.94 pb -1 for e + p collisions. Limits on coupling vs. mass are provided for leptoquarks and R-parity violating squarks. For flavor violating couplings of electromagnetic strength, we set 95% confidence level lower limits on leptoquark masses between 207 GeV and 272 GeV, depending on the leptoquark species and final-state lepton. For leptoquark masses larger than 300 GeV, limits on flavor-changing couplings are determined, many of which supersede prior limits from rare decay processes. (orig.)

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

DEFF Research Database (Denmark)

Lasko, Loren M; Jakob, Clarissa G; Edalji, Rohinton P

2017-01-01

-specific tumour types, including several haematological malignancies and androgen receptor-positive prostate cancer. A-485 inhibited the androgen receptor transcriptional program in both androgen-sensitive and castration-resistant prostate cancer and inhibited tumour growth in a castration-resistant xenograft...... to treat certain cancers, but progress on the development of drug-like histone actyltransferase inhibitors has lagged behind. The histone acetyltransferase paralogues p300 and CREB-binding protein (CBP) are key transcriptional co-activators that are essential for a multitude of cellular processes, and have...... also been implicated in human pathological conditions (including cancer). Current inhibitors of the p300 and CBP histone acetyltransferase domains, including natural products, bi-substrate analogues and the widely used small molecule C646, lack potency or selectivity. Here, we describe A-485, a potent...

High Temperature 300°C Directional Drilling System

Energy Technology Data Exchange (ETDEWEB)

Chatterjee, Kamalesh [Baker Hughes Oilfield Operations, Houston, TX (United States); Aaron, Dick [Baker Hughes Oilfield Operations, Houston, TX (United States); Macpherson, John [Baker Hughes Oilfield Operations, Houston, TX (United States)

2015-07-31

Many countries around the world, including the USA, have untapped geothermal energy potential. Enhanced Geothermal Systems (EGS) technology is needed to economically utilize this resource. Temperatures in some EGS reservoirs can exceed 300°C. To effectively utilize EGS resources, an array of injector and production wells must be accurately placed in the formation fracture network. This requires a high temperature directional drilling system. Most commercial services for directional drilling systems are rated for 175°C while geothermal wells require operation at much higher temperatures. Two U.S. Department of Energy (DOE) Geothermal Technologies Program (GTP) projects have been initiated to develop a 300°C capable directional drilling system, the first developing a drill bit, directional motor, and drilling fluid, and the second adding navigation and telemetry systems. This report is for the first project, “High Temperature 300°C Directional Drilling System, including drill bit, directional motor and drilling fluid, for enhanced geothermal systems,” award number DE-EE0002782. The drilling system consists of a drill bit, a directional motor, and drilling fluid. The DOE deliverables are three prototype drilling systems. We have developed three drilling motors; we have developed four roller-cone and five Kymera® bits; and finally, we have developed a 300°C stable drilling fluid, along with a lubricant additive for the metal-to-metal motor. Metal-to-metal directional motors require coatings to the rotor and stator for wear and corrosion resistance, and this coating research has been a significant part of the project. The drill bits performed well in the drill bit simulator test, and the complete drilling system has been tested drilling granite at Baker Hughes’ Experimental Test Facility in Oklahoma. The metal-to-metal motor was additionally subjected to a flow loop test in Baker Hughes’ Celle Technology Center in Germany, where it ran for more than 100

300 Area steam plant replacement, Hanford Site, Richland, Washington: Environmental assessment

International Nuclear Information System (INIS)

1997-03-01

Steam to support process operations and facility heating is currently produced by a centralized oil-fired plant located in the 300 Area and piped to approximately 26 facilities in the 300 Area. This plant was constructed during the 1940s and, because of tis age, is not efficient, requires a relatively large operating and maintenance staff, and is not reliable. The US Department of Energy is proposing an energy conservation measure for a number of buildings in the 300 Area of the Hanford Site. This action includes replacing the centralized heating system with heating units for individual buildings or groups of buildings, constructing new natural gas pipelines to provide a fuel source for many of these units and constructing a central control building to operate and maintain the system. A new steel-sided building would be constructed in the 300 Area in a previously disturbed area at least 400 m (one-quarter mile) from the Columbia River, or an existing 300 Area building would be modified and used. This Environmental Assessment evaluates alternatives to the proposed actions. Alternatives considered are: (1) the no action alternative; (2) use of alternative fuels, such as low-sulfur diesel oil; (3) construction of a new central steam plant, piping and ancillary systems; (4) upgrade of the existing central steam plant and ancillary systems; and (5) alternative routing of the gas distribution pipeline that is a part of the proposed action. A biological survey and culture resource review and survey were also conducted

Stratification in SNR-300 outlet plenum

International Nuclear Information System (INIS)

Reinders, R.

1983-01-01

In the inner outlet plenum of the SNR-300 under steady state conditions a large toroidal vortex is expected. The main flow passes through the gap between dipplate and shield vessel to the outer annular space. Only 3% of the flow pass the 24 emergency cooling holes, situated in the shield vessel. The sodium leaves the reactor tank through the 3 symmetrically arranged outlet nozzles. For a scram flow rates and temperatures are decreased simultaneously, so it is expected, that stratification occurs in the inner outlet plenum. A measure of stratification effects is the Archimedes Number Ar, which is the relation of buoyancy forces (negative) to kinetic energy. (The Archimedes Number is nearly identical with the Richardson Number). For values Ar>1 stratification can occur. Under the assumption of stratification the code TIRE was developed, which is only applicable for the period of time after some 50 sec after scram. This code serves for long term calculations. As the equations are very simple, it is a very fast code which gives the possibility to calculate transients for some hours real time. This code mainly has to take into account the pressure difference between inner plenum and outlet annulus caused by geodatic pressure. That force is in equilibrium with the pressure drop over the gap and holes in the shield vessel. For more detailed calculations of flow pattern and temperature distribution the code MIX and INKO 2T are applied. MIX was developed and validated at ANL, INKO 2T is a development of INTERATOM. INKO 2T is under validation. Mock up experiments were carried out with water to simulate the transient behavior of the SNR-300 outlet plenum. Calculations obtained by INKO 2T for steady state and the transient are shown for the flow pattern. Results of measurements also prove that stratification begins after about 30 sec. Measurements and detailed calculations show that it is admissible to use the code TIRE for the long term calculations. Calculations for a scram

Autoimmune regulator is acetylated by transcription coactivator CBP/p300

Energy Technology Data Exchange (ETDEWEB)

Saare, Mario, E-mail: mario.saare@ut.ee [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia); Rebane, Ana [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia); SIAF, Swiss Institute of Allergy and Asthma Research, University of Zuerich, Davos (Switzerland); Rajashekar, Balaji; Vilo, Jaak [BIIT, Bioinformatics, Algorithmics and Data Mining group, Institute of Computer Science, University of Tartu, Tartu (Estonia); Peterson, Paert [Molecular Pathology, Institute of General and Molecular Pathology, University of Tartu, 19th Ravila Str, Tartu (Estonia)

2012-08-15

The Autoimmune Regulator (AIRE) is a regulator of transcription in the thymic medulla, where it controls the expression of a large set of peripheral-tissue specific genes. AIRE interacts with the transcriptional coactivator and acetyltransferase CBP and synergistically cooperates with it in transcriptional activation. Here, we aimed to study a possible role of AIRE acetylation in the modulation of its activity. We found that AIRE is acetylated in tissue culture cells and this acetylation is enhanced by overexpression of CBP and the CBP paralog p300. The acetylated lysines were located within nuclear localization signal and SAND domain. AIRE with mutations that mimicked acetylated K243 and K253 in the SAND domain had reduced transactivation activity and accumulated into fewer and larger nuclear bodies, whereas mutations that mimicked the unacetylated lysines were functionally similar to wild-type AIRE. Analogously to CBP, p300 localized to AIRE-containing nuclear bodies, however, the overexpression of p300 did not enhance the transcriptional activation of AIRE-regulated genes. Further studies showed that overexpression of p300 stabilized the AIRE protein. Interestingly, gene expression profiling revealed that AIRE, with mutations mimicking K243/K253 acetylation in SAND, was able to activate gene expression, although the affected genes were different and the activation level was lower from those regulated by wild-type AIRE. Our results suggest that the AIRE acetylation can influence the selection of AIRE activated genes. -- Highlights: Black-Right-Pointing-Pointer AIRE is acetylated by the acetyltransferases p300 and CBP. Black-Right-Pointing-Pointer Acetylation occurs between CARD and SAND domains and within the SAND domain. Black-Right-Pointing-Pointer Acetylation increases the size of AIRE nuclear dots. Black-Right-Pointing-Pointer Acetylation increases AIRE protein stability. Black-Right-Pointing-Pointer AIRE acetylation mimic regulates a different set of AIRE

New photo-curable resin compositions for stereolithography with a new photo-fabricator: SCS-300P

International Nuclear Information System (INIS)

Yamamura Tetsuya; Tanabe Takayoshi; Ukachi Takashi

1999-01-01

Stereolithography is the technology which can create a three-dimensional free-forin in short time according to the slice data of an object. A thin layer of the solidified resin is formed at the surface of the liquid UV curable resin by irradiation of UV laser which is driven by the slice data of the object. Ever since the invention of the stereolithography, there has been a considerable interest to realize the CAD date into a practical three dimensional model. Conventional stereolithographic machines equip gas lasers which are operated at high voltage and requires water cooling system. These disadvantages prevent a wide spread of application of stereolithographic technology. A new sterolithographic machine, SCS-300P has been developed and introduced by SONY Corporation last year. This brand new machine is featuring a high power solid-state UV laser, low machine price, small in size and equips easy-resin-exchange system for maintenance. The biggest difference of SCS-300P from the conventional machines is the laser system. SCS-300P equips pulse laser with the wave length of 355 run which is a third harmonic of YAG laser. The energy of each pulse with a duration time of 20 nsec is more than five thousand times higher than that of continuous emission such as Argon ion laser employed in the conventional machines. With using conventional LTV curable resins, high photo-energy tends to give a gelation even in a dark region or give an undesirable excess-cure underneath of the cured layer. It is thus needed to develop the resin suitable for high power pulse lasers. In this paper, we report a newly developed UV curable resin compositions suitable for SCS-300P which equips high power solid-state pulse laser

24 CFR 214.300 - Counseling services.

Science.gov (United States)

2010-04-01

... to provide specified types of counseling nationally. (6) All participating agencies that offer group educational sessions must also offer individual counseling on the same topics covered in the group educational... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Counseling services. 214.300...

40 CFR 300.210 - Federal contingency plans.

Science.gov (United States)

2010-07-01

... contingency plans under the national response system: The National Contingency Plan, RCPs, and ACPs. These... discharge under § 300.324, and to mitigate or prevent a substantial threat of such a discharge, from a vessel, offshore facility, or onshore facility operating in or near the area. (2) The areas of...

Tritium retention on the surface of stainless steel samples fixed on the plasma-facing wall in LHD

International Nuclear Information System (INIS)

Matsuyama, Masao; Abe, Shinsuke; Nishimura, Kiyohiko; Ashikawa, Naoko; Sagara, Akio; Oya, Yasuhisa; Okuno, Kenji; Yamauchi, Yuji; Nobuta, Yuji

2014-01-01

Effects of pre-heating for retention and distribution of tritium have been studied using samples fixed on the wall of the Large Helical Device during a plasma campaign. The samples were fixed at four different locations. The plasma-facing surface of the samples was covered with deposition layers of different thickness in each sample. Retention behavior in deposition layers was observed using β-ray-induced X-ray spectrometry and imaging plate technique. Pre-heating of the samples in vacuum was changed in a temperature range from 300 to 623 K, and subsequent tritium exposure was carried out at 300 K in every runs. Non-uniformity of tritium distribution clearly appeared even in the as-received samples which was not pre-heated. It is considered, therefore, that non-uniform adsorption sites of tritium have been produced during a formation process of deposition layers. In addition, it was seen that the amount of tritium retention increased with an increase in the pre-heating temperature, indicating that adsorption sites of tritium were newly formed in the deposition layers by heating in vacuum. (author)

Classification effects of real and imaginary movement selective attention tasks on a P300-based brain-computer interface

Science.gov (United States)

Salvaris, Mathew; Sepulveda, Francisco

2010-10-01

Brain-computer interfaces (BCIs) rely on various electroencephalography methodologies that allow the user to convey their desired control to the machine. Common approaches include the use of event-related potentials (ERPs) such as the P300 and modulation of the beta and mu rhythms. All of these methods have their benefits and drawbacks. In this paper, three different selective attention tasks were tested in conjunction with a P300-based protocol (i.e. the standard counting of target stimuli as well as the conduction of real and imaginary movements in sync with the target stimuli). The three tasks were performed by a total of 10 participants, with the majority (7 out of 10) of the participants having never before participated in imaginary movement BCI experiments. Channels and methods used were optimized for the P300 ERP and no sensory-motor rhythms were explicitly used. The classifier used was a simple Fisher's linear discriminant. Results were encouraging, showing that on average the imaginary movement achieved a P300 versus No-P300 classification accuracy of 84.53%. In comparison, mental counting, the standard selective attention task used in previous studies, achieved 78.9% and real movement 90.3%. Furthermore, multiple trial classification results were recorded and compared, with real movement reaching 99.5% accuracy after four trials (12.8 s), imaginary movement reaching 99.5% accuracy after five trials (16 s) and counting reaching 98.2% accuracy after ten trials (32 s).

75 FR 76926 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Science.gov (United States)

2010-12-10

... Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and Model C4-605R... airplanes; Model A300 B4-605R and B4-622R airplanes; Model A300 F4-605R and F4-622R airplanes; Model A300 C4...

Design and development of GTHTR300