Women Behaving Badly: Dahl's Witches Meet the Women of the Eighties.

Science.gov (United States)

Bird, Anne-Marie

1998-01-01

Investigates the issue of misogyny in Roald Dahl's 1983 book and Nicolas Roeg's 1989 film, "The Witches." Looks at the general differences in the two texts--the most explicit difference is in the film's ending. Explores the significance of the witch in the book and to what extent Roeg's film uses the implied connection between evil and gender. (PA)

Salem 98: A post-plume phase, federal participation exercise

International Nuclear Information System (INIS)

1999-01-01

Salem 98 was the largest nuclear power plant post-plume phase exercise since the 1993 FRMAC-93 exercise at the Fort Calhoun Nuclear Power Plant in Nebraska. Salem 98 was a 3 Day exercise, held on May 5--7, 1998, involving participation by the States of New Jersey and Delaware and associated State and county agencies. Public Service Electric and Gas was the host utility and Salem County the host county. Federal participation included the Nuclear Regulatory Commission, Federal Emergency Management Agency, Department of Energy, Environmental Protection Agency, US department of Agriculture and Department of Health and Human Services. In addition, the American Nuclear Insurers participated, adding a dimension to the exercise not experienced often enough. This was a stand-alone post-plume phase exercise, which took place 2 months after the evaluated plume phase exercise held on March 3, 1998, also including participation by various Federal agencies. This exercise demonstrated the positive working relationship among utility, State, county, and Federal responders in response to a postulated major nuclear power plant emergency with significant offsite consequences

Salem 98: A post-plume phase, federal participation exercise

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-01-01

Salem 98 was the largest nuclear power plant post-plume phase exercise since the 1993 FRMAC-93 exercise at the Fort Calhoun Nuclear Power Plant in Nebraska. Salem 98 was a 3 Day exercise, held on May 5--7, 1998, involving participation by the States of New Jersey and Delaware and associated State and county agencies. Public Service Electric and Gas was the host utility and Salem County the host county. Federal participation included the Nuclear Regulatory Commission, Federal Emergency Management Agency, Department of Energy, Environmental Protection Agency, US department of Agriculture and Department of Health and Human Services. In addition, the American Nuclear Insurers participated, adding a dimension to the exercise not experienced often enough. This was a stand-alone post-plume phase exercise, which took place 2 months after the evaluated plume phase exercise held on March 3, 1998, also including participation by various Federal agencies. This exercise demonstrated the positive working relationship among utility, State, county, and Federal responders in response to a postulated major nuclear power plant emergency with significant offsite consequences.

33 CFR 165.116 - Safety and Security Zones; Salem and Boston Harbors, Massachusetts.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Safety and Security Zones; Salem..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED NAVIGATION AREAS AND LIMITED... § 165.116 Safety and Security Zones; Salem and Boston Harbors, Massachusetts. (a) Location. The...

The Witch's Mask in Throne of Blood (Humanitie)(Language and Literature)

OpenAIRE

KREMENIK, Michael

2000-01-01

The character and story of the witch in Kurosawa Akira's film Throne of Blood (Kumonosujou in Japanese) will be analyzed. The character and story borrow elements from two Noh plays, Yamanba and Kurozuka. The mask of Yamanba and the story of Kurozuka are fused by Kurosawa into the witch character of Throne of Blood.

The WITCH experiment: towards weak interactions studies. Status and prospects

International Nuclear Information System (INIS)

Kozlov, V. Yu.; Beck, M.; Coeck, S.; Herbane, M.; Kraev, I. S.; Severijns, N.; Wauters, F.; Delahaye, P.; Herlert, A.; Wenander, F.; Zakoucky, D.

2006-01-01

Primary goal of the WITCH experiment is to test the Standard Model for a possible admixture of a scalar or tensor type interaction in β-decay. This information will be inferred from the shape of the recoil energy spectrum. The experimental set-up was completed and is under intensive commissioning at ISOLDE (CERN). It combines a Penning trap to store the ions and a retardation spectrometer to probe the recoil ion energy. A brief overview of the WITCH set-up and the results of commissioning tests performed until now are presented. Finally, perspectives of the physics program are reviewed.

Multi-Century Record of Anthropogenic Impacts on an Urbanized Mesotidal Estuary: Salem Sound, MA

Science.gov (United States)

Salem, MA, located north of Boston, has a rich, well-documented history dating back to settlement in 1626 CE, but the associated anthropogenic impacts on Salem Sound are poorly constrained. This project utilized dated sediment cores from the sound to assess the proxy record of an...

Pathogen Transport and Fate Modeling in the Upper Salem River Watershed Using SWAT Model

Science.gov (United States)

SWAT (Soil and Water Assessment Tool) is a dynamic watershed model that is applied to simulate the impact of land management practices on water quality over a continuous period. The Upper Salem River, located in Salem County New Jersey, is listed by the New Jersey Department of ...

Beyond Historical Fiction: Speare's "The Witch of Blackbird Pond."

Science.gov (United States)

Thuente, Mary Helen

1985-01-01

Reviews "The Witch of Blackbird Pond" by E. Speare to show how the full narrative power of the novel derives from the author's successful integration of two separate narrative genres: historical fiction and the folktale. (EL)

Nowy wymiar strachu : "Blair Witch Project" (1999) Daniela Myricka i Eduardo Sáncheza

OpenAIRE

Kwiatkowski, Fryderyk

2013-01-01

The feature-film debut "Blair Witch Project" (1999) by Daniel Myrick and Eduardo Sánchez was an unexpected box-office hit. In spite of having a very low-budget and no movie stars in the cast, the directors adapted new means through which horror could be compellingly depicted on screen. The author of the article intends to unravel why so many viewers of "Blair Witch Project" believed that it presented a true story. On the one hand, it is connected with a well-prepared marketing campaign conduc...

Aspectos discursivos em As Bruxas de Salem: peça e filme

OpenAIRE

Pinheiro, Eder Sergio

2009-01-01

Esta pesquisa, cujo título é Aspectos Discursivos em As Bruxas de Salem: eça e Filme, propõe discutir a transposição da linguagem escrita, neste caso, as rubricas da peça de teatro para a linguagem fílmica, devido a problemática das duas linguagens se diferenciarem, convergirem-se e cruzarem-se ao mesmo tempo. Deste modo, dois fragmentos foram escolhidos para análise, sendo eles: um trecho da peça escrita As Bruxas de Salem (1953) e outro do filme (1976), ambos os trechos são correspondent...

Nowy wymiar strachu - Blair Witch Project (1999) Daniela Myricka i Eduardo Sáncheza

OpenAIRE

Kwiatkowski, Fryderyk

2013-01-01

The feature-film debut “Blair Witch Project” (1999) by Daniel Myrick and Eduardo Sánchez was an unexpected box-office hit. In spite of having a very low-budget and no movie stars in the cast, the directors adapted new means through which horror could be compellingly depicted on screen. The author of the article intends to unravel why so many viewers of “Blair Witch Project” believed that it presented a true story. On the one hand, it is connected with a well-prepared marketing campaign conduc...

Genetic architecture and bottleneck analyses of Salem Black goat breed based on microsatellite markers

Directory of Open Access Journals (Sweden)

A. K. Thiruvenkadan

2014-09-01

Full Text Available Aim: The present study was undertaken in Salem Black goat population for genetic analysis at molecular level to exploit the breed for planning sustainable improvement, conservation and utilization, which subsequently can improve the livelihood of its stakeholders. Materials and Methods: Genomic DNA was isolated from blood samples of 50 unrelated Salem Black goats with typical phenotypic features in several villages in the breeding tract and the genetic characterization and bottleneck analysis in Salem Black goat was done using 25 microsatellite markers as recommended by the Food and Agricultural Organization, Rome, Italy. The basic measures of genetic variation were computed using bioinformatic software. To evaluate the Salem Black goats for mutation drift equilibrium, three tests were performed under three different mutation models, viz., infinite allele model (IAM, stepwise mutation model (SMM and two-phase model (TPM and the observed gene diversity (He and expected equilibrium gene diversity (Heq were estimated under different models of microsatellite evolution. Results: The study revealed that the observed number of alleles ranged from 4 (ETH10, ILSTS008 to 17 (BM64444 with a total of 213 alleles and mean of 10.14±0.83 alleles across loci. The overall observed heterozygosity, expected heterozygosity, inbreeding estimate and polymorphism information content values were 0.631±0.041, 0.820±0.024, 0.233±0.044 and 0.786±0.023 respectively indicating high genetic diversity. The average observed gene diversities (He pooled over different markers was 0.829±0.024 and the average expected gene diversities under IAM, TPM and SMM models were 0.769±0.026, 0.808±0.024 and 0.837±0.020 respectively. The number of loci found to exhibit gene diversity excess under IAM, TPM and SMM models were 18, 17 and 12 respectively. Conclusion: All the three statistical tests, viz., sign test, standardized differences test and Wilcoxon sign rank test, revealed

SaLEM (v1.0) - the Soil and Landscape Evolution Model (SaLEM) for simulation of regolith depth in periglacial environments

Science.gov (United States)

Bock, Michael; Conrad, Olaf; Günther, Andreas; Gehrt, Ernst; Baritz, Rainer; Böhner, Jürgen

2018-04-01

We propose the implementation of the Soil and Landscape Evolution Model (SaLEM) for the spatiotemporal investigation of soil parent material evolution following a lithologically differentiated approach. Relevant parts of the established Geomorphic/Orogenic Landscape Evolution Model (GOLEM) have been adapted for an operational Geographical Information System (GIS) tool within the open-source software framework System for Automated Geoscientific Analyses (SAGA), thus taking advantage of SAGA's capabilities for geomorphometric analyses. The model is driven by palaeoclimatic data (temperature, precipitation) representative of periglacial areas in northern Germany over the last 50 000 years. The initial conditions have been determined for a test site by a digital terrain model and a geological model. Weathering, erosion and transport functions are calibrated using extrinsic (climatic) and intrinsic (lithologic) parameter data. First results indicate that our differentiated SaLEM approach shows some evidence for the spatiotemporal prediction of important soil parental material properties (particularly its depth). Future research will focus on the validation of the results against field data, and the influence of discrete events (mass movements, floods) on soil parent material formation has to be evaluated.

PATHOGEN TRANSPORT AND FATE MODELING IN THE UPPER SALEM RIVER WATERSHED USING SWAT MODEL - PEER-REVIEWED JOURNAL ARTICLE

Science.gov (United States)

Simulation of the fate and transport of pathogen contamination was conducted with SWAT for the Upper Salem River Watershed, located in Salem County, New Jersey. This watershed is 37 km2 and land uses are predominantly agricultural. The watershed drains to a 32 km str...

Progress at the WITCH experiment towards weak interaction studies

CERN Document Server

Tandecki, Michaël

A measurement of the $\\beta$–ν angular correlation in nuclear $\\beta$- decay is a good probe to search for physics beyond the Standard Model, independent of assumptions like parity, charge and time reversal violation. The WITCH (Weak Interaction Trap for Charged Particles) experiment will measure this correlation with the aim of further constraining the possible existence of scalar currents in the weak interaction or find a positive indication. The setup is located at ISOLDE/CERN and consists of a double Penning trap system combined with a retardation spectrometer to probe the energy of the recoil ions from the $\\beta$- decay. The shape of the recoil ion energy spectrum allows to determine the $\\beta$–ν angular correlation coefficient, $a$. Past experiments have allowed to measure this parameter with a precision of 0.5–1 %. The aim of the WITCH experiment is to measure $a$ with a precision of about 0.5 %.\\\\ A first step towards this goal has already been taken in 2006 with the measurement of a recoil ...

SaLEM (v1.0 – the Soil and Landscape Evolution Model (SaLEM for simulation of regolith depth in periglacial environments

Directory of Open Access Journals (Sweden)

M. Bock

2018-04-01

Full Text Available We propose the implementation of the Soil and Landscape Evolution Model (SaLEM for the spatiotemporal investigation of soil parent material evolution following a lithologically differentiated approach. Relevant parts of the established Geomorphic/Orogenic Landscape Evolution Model (GOLEM have been adapted for an operational Geographical Information System (GIS tool within the open-source software framework System for Automated Geoscientific Analyses (SAGA, thus taking advantage of SAGA's capabilities for geomorphometric analyses. The model is driven by palaeoclimatic data (temperature, precipitation representative of periglacial areas in northern Germany over the last 50 000 years. The initial conditions have been determined for a test site by a digital terrain model and a geological model. Weathering, erosion and transport functions are calibrated using extrinsic (climatic and intrinsic (lithologic parameter data. First results indicate that our differentiated SaLEM approach shows some evidence for the spatiotemporal prediction of important soil parental material properties (particularly its depth. Future research will focus on the validation of the results against field data, and the influence of discrete events (mass movements, floods on soil parent material formation has to be evaluated.

Control rod trip failures; Salem 1, the cause, response, and potential fixes

International Nuclear Information System (INIS)

Hall, R.E.; Boccio, J.L.; Luckas, W.J.

1984-01-01

This chapter presents a systems and reliability analysis of recent nuclear reactor control rod failure-to-trip (or scram) events that have been experienced in the US commercial nuclear industry. The operational factors of hardware, procedures, and human error are considered in the analysis of transients without scram. The 1980 Browns Ferry 3 scram system failure is analyzed to contrast the two 1983 Salem 1 events. The details of the Salem control rod failure to trip are investigated and used to calculate the reactor protection system unavailabilities. The internal reactor trip breaker logic is reviewed as related to the Westinghouse DB-50 breaker application. The impact of test and maintenance on system challenges is discussed. It is concluded that although the failure to trip or scram represents a single class of initiators, the actual events of each transient are operationally unique and require individual human responses

A novel lignin-based surfactant system for the Salem Unit

International Nuclear Information System (INIS)

DeBons, F.E.; Whittington, L.E.

1991-01-01

Texaco conducted a successful surfactant/polymer flood in a 60-acre [24 ha] portion of the Salem Benoist reservoir in Salem, Illinois, in 1981. This pilot used a brine-tolerant petroleum sulfonate surfactant system blended in injection brine followed by a xanthan mobility control polymer in fresher water. The oil recovery over the seven year life of the flood was 487,050 bbl [77 435 m 3 ]. This represents 45% of the oil remaining in the total thickness of 73% of that from the more permeable lower interval where most of the surfactant flowed. Since this successful project, Texaco has continued to improve enhanced oil recovery surfactant systems. We have developed novel, brine tolerant surfactants based on the renewable resources lignin and tallow amine. This paper describes the laboratory work leading to a surfactant system which has been recommended for field testing. The laboratory work includes blending, interfacial tension measurements, and core floods in Berea and reservoir cores. The type of lignin based surfactant system described in this report has applicability in all fields where conventional petroleum-based surfactants have been used. Their much lower cost means that they can be used economically at lower crude oil prices

Search for physics beyond the standard electroweak model with the WITCH experiment

CERN Document Server

Van Gorp, Simon

A measurement of the $\\beta$-neutrino angular correlation coefficient $a$ yields information on possible exotic couplings in the weak interaction. To this end the energy distribution of the recoiling daughter nucleus after $\\beta$-decay, which depends on $a$, is measured precisely. Any deviation of the measured distribution with the one expected from the Standard Model can reveal new physics. If no deviation is found stringent limits can be set on the possible presence of different types of new physics beyond the Standard Model. The WITCH experiment, located at ISOLDE, CERN aims to determine $a$ with a final precision below 1%. $\\\\$ Ion bunches are created with REXTRAP and injected in the WITCH setup. The energy of these ion bunches is pulsed down in the Pulsed Drift Tube section, prior to the capture of the ions in the first of two Penning traps. The motion of the radioactive ions is cooled before the transfer to a second Penning trap, the decay trap, which acts as the scattering-free sou...

A "clean cigarette" for a clean nation: a case study of Salem Pianissimo in Japan.

Science.gov (United States)

Assunta, M; Chapman, S

2004-12-01

To illustrate, through internal industry documents, how RJ Reynolds exploited the concerns of the Japanese society about cleanliness to market the concept of cleaner, implicitly healthier cigarettes in Japan. Systematic keyword and opportunistic website searches of formerly private internal industry documents. Industry documents show that RJ Reynolds developed marketing plans based upon their cultural assumptions of Japanese people as fastidious about hygiene and manners, and with relatively high penchants to try new products. RJ Reynolds found there was also a growing concern for health, the environment, and smokers were conscious about annoying others. Deodorised consumer products were one of Japan's biggest trends. These characteristics presented RJ Reynolds with a profitable formula for marketing Salem Pianissimo, a clean cigarette with less smell and smoke. Salem Pianissimo, a 100 mm cigarette claiming to contain 1 mg tar and 0.1 mg nicotine, targeted women since menthol cigarettes were popular among 18-24 year old female smokers, although Japan's law prohibited those below 20 years to smoke and the tobacco industry had a voluntary code disallowing advertising to women and youth. RJ Reynolds successfully launched its clean cigarette, Salem Pianissimo, in Japan aiming to exploit perceived cultural characteristics such as a penchant for cleanliness, an eagerness to try new products, and social harmony.

75 FR 20033 - Winston-Salem Southbound Railway Company-Corporate Family Transaction Exemption-High Point...

Science.gov (United States)

2010-04-16

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Finance Docket No. 35338] Winston-Salem Southbound Railway Company--Corporate Family Transaction Exemption--High Point, Thomasville... under 49 CFR 1180.2(d)(3) for a transaction within a corporate family. Applicants state that HPTD will...

When people with dementia are perceived as witches. Consequences for patients and nurse education in South Africa.

Science.gov (United States)

Mkhonto, Flora; Hanssen, Ingrid

2018-01-01

To explore and describe the link between culture and dementia care with the focus on the influence of the belief in dementia as witchcraft and people with dementia as witches. In South Africa, especially in townships and rural areas, dementia is often perceived as connected to witchcraft rather than to disease. Persons labelled as witches-mostly older women-may be bullied, ostracised, beaten, stoned, burned, even killed. One strand of findings from a larger international study is presented with in-depth qualitative interviews of one close family member and seven nurses caring for patients with severe dementia in nursing homes in Tshwane in South Africa. A hermeneutic analytic approach was used. Two main themes are found, namely "Belief in witchcraft causing fear of persons with dementia" and "Need of knowledge and education." Fear of and violence towards people with dementia are based on the belief that they are witches. Some of the nurses had also held this belief until they started working with patients with dementia. There is a great need for education both among healthcare workers and the populace. The "witch" belief prevents seeking professional help. As nursing homes tend to be private and expensive, professional dementia care is virtually unattainable for the poor. Dementia needs a more prominent place in nursing curricula. Nurses as educators need to know the local culture and language to be accepted in the various communities. They need to visit families affected by dementia, give awareness talks in churches, schools and clinics and facilitate support groups for carers of people with dementia in the local language. Improved nurses' education in gerontology and geriatric care is needed. Trained specialist nurses may work as mediators and help eradicate the witchcraft beliefs connected to severe dementia. © 2017 John Wiley & Sons Ltd.

Beyond the Criminal Arena: The Justice Studies Program at Winston-Salem State University

Science.gov (United States)

Harvey, Lynn K.; Mitchell, Alvin D.

2006-01-01

The justice studies program at Winston-Salem State University (WSSU) is designed to produce a new breed of justice practitioners whose understanding of justice and its administration is broadened to include the political, social, economic, and cultural conditions within which issues of crime and punishment are pursued and addressed. While it…

Cinema advertising and the Sea Witch ‘Lost Island’ film (1965)

OpenAIRE

Farmer, Richard

2016-01-01

Cinema advertising films have for many decades constituted an important element of British cinema programmes, yet they remain relatively under-researched. This article examines the production, distribution and reception of one such film, a 90-second mini-epic called ‘Lost Island’, which was made in 1965 to promote Sea Witch hair dyes. As well as outlining the technological and experiential aspects of the cinema and cinemagoing that continued to make film an attractive medium for advertisers e...

Musculoskeletal disorders and mental health-related issues as occupational hazards among dental practitioners in Salem city: A cross-sectional study

Directory of Open Access Journals (Sweden)

Vanita D Revankar

2017-01-01

Full Text Available Background: Like in any other profession, dental surgeons are also afflicted by many occupational health hazards such as Musculoskeletal disorders (MSD and mental health related issues. Aims: To assess the distribution of MSD and mental health related issues amidst dentists in Salem City according to age, sex and number of working hours per week. Objectives: A survey was organized to check the rate of occurrence of these occupational health hazards among dental practitioners in Salem city. Materials and Methods: The study was conducted among one hundred and fifty dentists practicing in Salem City in the form of questionnaire. Dentists were asked about any occupational disease that they suffered related to a musculo–skeletal pain and its location whether in the back, upper limbs or lower limbs. In addition to this,dentists were asked about mental stress that they had experienced. Results: MSD showed higher rate of prevalence compared to mental health related issues. Conclusion: The application of preventive measures is necessary, in view of the high rate of these disorders in the society of dental practitioners.

The Anatomy of a Witch: Lessons in English Language, Literature and Improvisation

Directory of Open Access Journals (Sweden)

Željka (Nemet Flegar

2015-11-01

Full Text Available The paper provides a brief outline of the historical development, principles and implementation of improvisational theatre in both the theatrical and non-theatrical context in order to present the art of improvisation as a strategy in foreign and second language acquisition. Research shows that because of the adaptability of the improvisational game structure which allows for the applicability of improvisational techniques in different contexts and with subjects of various backgrounds, improvisational theatre can be incorporated in teaching an array of subjects and topics, including English as a foreign and second language. In order to demonstrate the possible application of the improvisational strategy in English language teaching, there is a detailed description of an interdisciplinary workshop The English Anatomy of a Witch, focusing on the oral tradition of storytelling and the fairy tale as the direct product of both storytelling and improvisational practices, which contains different aspects of improvisational techniques in the classroom setting. By discussing the figure of the witch, which is anthropologically and historically present in British and American culture, the workshop aims to achieve a number of goals and objectives pertaining to both foreign and second language acquisition, the re-evaluation of the literary tradition, as well as pedagogies that foster critical and divergent thinking.

First high-statistics and high-resolution recoil-ion data from the WITCH retardation spectrometer

Science.gov (United States)

Finlay, P.; Breitenfeldt, M.; Porobić, T.; Wursten, E.; Ban, G.; Beck, M.; Couratin, C.; Fabian, X.; Fléchard, X.; Friedag, P.; Glück, F.; Herlert, A.; Knecht, A.; Kozlov, V. Y.; Liénard, E.; Soti, G.; Tandecki, M.; Traykov, E.; Van Gorp, S.; Weinheimer, Ch.; Zákoucký, D.; Severijns, N.

2016-07-01

The first high-statistics and high-resolution data set for the integrated recoil-ion energy spectrum following the β^+ decay of 35Ar has been collected with the WITCH retardation spectrometer located at CERN-ISOLDE. Over 25 million recoil-ion events were recorded on a large-area multichannel plate (MCP) detector with a time-stamp precision of 2ns and position resolution of 0.1mm due to the newly upgraded data acquisition based on the LPC Caen FASTER protocol. The number of recoil ions was measured for more than 15 different settings of the retardation potential, complemented by dedicated background and half-life measurements. Previously unidentified systematic effects, including an energy-dependent efficiency of the main MCP and a radiation-induced time-dependent background, have been identified and incorporated into the analysis. However, further understanding and treatment of the radiation-induced background requires additional dedicated measurements and remains the current limiting factor in extracting a beta-neutrino angular correlation coefficient for 35Ar decay using the WITCH spectrometer.

Prevalence of early childhood caries and its risk factors in 18-72 month old children in Salem, Tamil Nadu.

Science.gov (United States)

Stephen, Arokiaraj; Krishnan, Ramesh; Ramesh, Maya; Kumar, Vasaviah Suresh

2015-01-01

Early childhood caries (ECC) is one of the most common dental diseases among the preschoolers, leading to suboptimal health. A study was planned to evaluate the prevalence of ECC in preschool children in the age group between 18 and 72 months and its relationship with parent's education and socioeconomic status of the family. This cross-sectional study was conducted among 2771 children selected randomly, in the age group 18-72 months and attending playschools and primary schools in urban, semi-urban, and rural areas of Salem, Tamil Nadu. A modified Winter et al. questionnaire and a proforma were used for collecting information on each child. The completed questionnaire and proformas were statistically analyzed and evaluated. The statistical analysis was done using Student's t-test and analysis of variance (ANOVA) to obtain mean values. The prevalence of ECC in Salem was 16% with a mean dfs of 5.23 ± 1. Prevalence was high among the children of low socioeconomic status group and the children of working mothers, with a mean dfs of 10.47. The prevalence of ECC was 16% in Salem, Tamil Nadu. ECC was seen more in children of working mothers, lower parental education, and lower socioeconomic groups.

Abundance and diversity of Odonata in temporary water bodies of Coimbatore and Salem districts in Tamil Nadu

Directory of Open Access Journals (Sweden)

R. Arulprakash

2010-07-01

Full Text Available Odonata diversity was assessed in 13 temporary water bodies of Coimbatore and Salem districts in Tamil Nadu. Assessment revealed the presence of 21 species of Odonata (14 species of Anisoptera and seven species of Zygoptera belonging to 17 genera under four families. Libellulidae (Anisoptera was represented by the maximum number of species and individuals. Pantala flavescens (Libellulidae was the most abundant among 21 species. Among the temporary water bodies, the maximum number of individuals as well as species was recorded from Utkulam tank (Coimbatore district. Odonata diversity was higher in Kamalapuram tanks 1 and 2 (Salem district and lower in Ukkadam tank (Coimbatore District. Diplacodes trivialis (Rambur, Orthetrum sabina (Drury and Pantala flavescens (Fabricius were identified as temporary water body specialists because of their presence in all the 13 temporary water bodies sampled.

Witches and Indian Women, Daughters of Saturn: Arts, Witchcraft and Cannibalism

Directory of Open Access Journals (Sweden)

Yobenj Aucardo Chicangana-Bayona

2009-01-01

Full Text Available The article inquires into the representation of women in the paintings and engravings about witchcraft in the XVI-XVII centuries, trying to establish an iconographic typology and covering the construction of negative stigmas attributed to the feminine body and its natural degradation. Through the support of visual sources such as paintings and engravings, mainly from the German Renaissance, the text demonstrates how the Indian women of the New World were associated to the witches of Europe and with the classic god Saturn, through the myth of cannibalism.

Internal fire analysis screening methodology for the Salem Nuclear Generating Station

International Nuclear Information System (INIS)

Eide, S.; Bertucio, R.; Quilici, M.; Bearden, R.

1989-01-01

This paper reports on an internal fire analysis screening methodology that has been utilized for the Salem Nuclear Generating Station (SNGS) Probabilistic Risk Assessment (PRA). The methodology was first developed and applied in the Brunswick Steam Electric Plant (BSEP) PRA. The SNGS application includes several improvements and extensions to the original methodology. The SNGS approach differs significantly from traditional fire analysis methodologies by providing a much more detailed treatment of transient combustibles. This level of detail results in a model which is more usable for assisting in the management of fire risk at the plant

Geophysical exploration for uranium in Suryamalai batholith, Salem District, Tamil Nadu, India

Energy Technology Data Exchange (ETDEWEB)

Anantharaman, K B; Sethuram, S [Department of Atomic Energy, Hyderabad (India). Atomic Minerals Div.

1984-08-01

Abnormally radioactive granitoids are targets of uranium exploration because they can be the source for uranium deposits as well as the hosts. Significant uranium mineralization is known to occur northwest of Suryamalai granite batholith at Kullampatti situated 40 km southwest of Salem. This paper embodies the geophysical exploration for uranium, using results of magnetic and radiometric methods. The investigations revealed that uranium mineralization is structurally controlled and such structures have magnetic expression. Incidentally, correlation of anomalous content of W with U is also brought to light.

76 FR 19148 - PSEG Nuclear, LLC, Hope Creek Generating Station and Salem Nuclear Generating Station, Units 1...

Science.gov (United States)

2011-04-06

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-272, 50-311, 50-354; NRC-2009-0390 and NRC-2009-0391] PSEG Nuclear, LLC, Hope Creek Generating Station and Salem Nuclear Generating Station, Units 1 and 2..., DPR-70, and DPR-75 for an additional 20 years of operation for the Hope Creek Generating Station (HCGS...

75 FR 76040 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

Science.gov (United States)

2010-12-07

..., Winston-Salem, North Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR... from Staffing Solutions, South East, and Omni Resources and Recovery. The notices were published in the... firm. The workers are engaged in employment related to the production of desktop computers. New...

76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

Science.gov (United States)

2011-01-14

..., APN and ICONMA, Winston-Salem, North Carolina. The notice was published in the Federal Register on... Seaton Corporation. The notices were published on the Federal Register on April 19, 2010 (75 FR 20385... workers are engaged in employment related to the production of desktop computers. New information shows...

75 FR 6223 - PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1...

Science.gov (United States)

2010-02-08

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-272, 50-311 and 50-354; NRC-2010-0043] PSEG Nuclear LLC; Hope Creek Generating Station and Salem Nuclear Generating Station, Unit Nos. 1 and 2...-70, and DPR-75, issued to PSEG Nuclear LLC (PSEG, the licensee), for operation of the Hope Creek...

Vinten exposure measurements of the Salem Unit 1 lower core barrel

International Nuclear Information System (INIS)

Glennon, P.T.

1988-01-01

On November 6, 1987, the lower core barrel of Salem Unit I was removed from the reactor vessel and placed in the refueling pool as part of the unit's ten year inspection program. This paper deals with the supporting actions of the dosimetry group of PSE ampersand G. Prior to the move of the lower core barrel, Westinghouse predicted dose rates at one foot in water as a function of axial distance along the core barrel. This prediction was used in planning the health physics requirements associated with the move. It was agreed that a measurement of the axial dose rates would either lend confidence to the predictions or identify weaknesses in them

Comparative Evaluation of Dental and Skeletal Fluorosis in an Endemic Fluorosed District, Salem, Tamil Nadu.

Science.gov (United States)

Ramesh, Maya; Malathi, N; Ramesh, K; Aruna, Rita Mary; Kuruvilla, Sarah

2017-11-01

High levels of fluoride in the drinking water, especially ground water, results in skeletal fluorosis which involves the bone and major joints. This study was conducted to assess the prevalence of skeletal fluorosis to compare with dental fluorosis in an endemically fluorosed population in the District of Salem, Tamil Nadu. Institutional ethical clearance was obtained. A total of 206 patients who reported to the Department of Hematology for blood investigations were the participants in this study. Age, sex, place, weight, height, dental fluorosis, and skeletal complaints were noted down. Body mass index was calculated, and statistical analysis was performed. Dental fluorosis was present in 63.1% and absent in 36.9% of the samples reported. Skeletal fluorosis was present in 24.8% and was absent in 75.2%. A large number of the patients had knee pain and difficulty in bending. Chi-square test was used for statistical analysis. Skeletal fluorosis and age were compared and P value was 0.00 and was significant. Dental fluorosis and skeletal fluorosis were compared and P value was found to be 0.000 and significant. There is a need to take measures to prevent dental and skeletal fluorosis among the residents of Salem district. Calcium balance should be maintained, and fluoride intake should be minimized to reduce the symptoms. The government should provide water with low fluoride level for drinking and cooking. Once the symptoms develop, treatment largely remains symptomatic, using analgesics and physiotherapy.

Studies in Teaching: 2017 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2017)

Science.gov (United States)

McCoy, Leah P., Ed.

2017-01-01

This document presents the proceedings of the 22nd Annual Research Forum held June 29, 2017, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 12 action research papers: (1) Using Captioned Video to Teach Listening Comprehension in a Spanish Classroom (Michelle Allen); (2) Multimodal Instruction: How Film…

Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

Science.gov (United States)

McCoy, Leah P., Ed.

2016-01-01

This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

Study on the distribution of "2"1"0Po in water and soil samples of Attur taluk, Salem district, Tamilnadu

International Nuclear Information System (INIS)

Murali, M.; Periyasamy, M.; Syed Mohamed, H.E; Sadiq Bukhari, A.; Abrass Begam, A.; Zahir Husain, A.

2017-01-01

The present study was carried out to investigate the distribution of the alpha emitting radionuclide, "2"1"0Po in the ground water and soil samples of Attur taluk of salem district, Tamilnadu and the concentration is observed between water and soil (1.9 mBq/L and 3.9 Bq/Kg) respectively which is less than that of the world standards. (author)

Studies in Teaching: 2015 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 25, 2015)

Science.gov (United States)

McCoy, Leah P., Ed.

2015-01-01

This document presents the proceedings of the 20th Annual Research Forum held June 25, 2015, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 21 action research papers: (1) History Lives! The Use of Simulations in a High School Social Studies Classroom (Lydia Adkins); (2) Using Francophone Music in the High…

Crisis del personaje. La bruja en la era tecnológica / Character Crisis. The witch in the technological age

Directory of Open Access Journals (Sweden)

Carmen Mª Sánchez Morillas

2013-06-01

Full Text Available Resumen: Entre las múltiples imágenes que del personaje femenino aparecen en los cuentos, la de la bruja es la menos apreciada en su evolución, sobre todo a raíz de la aparición de las películas de Walt Disney, donde se produce la erotización del personaje, efecto ampliado en el cómic Anime, a la vez que, y de forma paralela, en la narrativa infantil-juvenil se le concede los caracteres de ente humanizado. Por tanto, analizaremos la evolución histórica que sobre el personaje bruja se ha realizado en representaciones culturales literarias y audiovisuales desde la segunda década del siglo XX hasta nuestros días.Abstract: Among the multiple images of the female character appear in tales of the witch is the least appreciated in its evolution, especially following the emergence of the films of Walt Disney, which produces the eroticization of the character, in effect extended Anime comic, while, in parallel and in child and adolescent narrative is given characters being humanized. Therefore, we will analyze the historical evolution of the character witch was made in literary and audiovisual cultural performances during the second decade of the twentieth century to today.

Groundwater quality assessment using geospatial and statistical tools in Salem District, Tamil Nadu, India

Science.gov (United States)

Arulbalaji, P.; Gurugnanam, B.

2017-10-01

The water quality study of Salem district, Tamil Nadu has been carried out to assess the water quality for domestic and irrigation purposes. For this purpose, 59 groundwater samples were collected and analyzed for pH, electrical conductivity (EC), total dissolved solids (TDS), major anions (HCO3 -, CO3 -, F-, Cl-, NO2 - + NO3 -, and SO4 2-), major cations (Ca2+ Mg2+, Na+, and K+), alkalinity (ALK), and hardness (HAR). To assess the water quality, the following chemical parameters were calculated based on the analytical results, such as Piper plot, water quality index (WQI), sodium adsorption ratio (SAR), magnesium hazard (MH), Kelly index (KI), and residual sodium carbonate (RSC). Wilcox diagram represents that 23% of the samples are excellent to good, 40% of the samples are good to permissible, 10% of the samples are permissible to doubtful, 24% of the samples are doubtful unsuitable, and only 3% of the samples are unsuitable for irrigation. SAR values shows that 52% of the samples indicate high-to-very high and low-to-medium alkali water. KI values indicate good quality (30%) and not suitable (70%) for irrigation purposes. RSC values indicate that 89% of samples are suitable for irrigation purposes. MH reveals that 17% suitable and 83% samples are not suitable for irrigation purposes and for domestic purposes the excellent (8%), good (48%), and poor (44%). The agricultural waste, fertilizer used, soil leaching, urban runoff, livestock waste, and sewages are the sources of poor water quality. Some samples are not suitable for irrigation purposes due to high salinity, hardness, and magnesium concentration. In general, the groundwater of the Salem district was polluted by agricultural activities, anthropogenic activities, ion exchange, and weathering.

New Jersey's experience with implementing Protective Action Guides during the 1988 Salem ingestion pathway exercise

International Nuclear Information System (INIS)

White, Duncan

1989-01-01

On November 30 and December 1, 1988, the New Jersey Department of Environmental Protection (DEP) and three other State agencies (Health, Agriculture and State Police) participated in the ingestion pathway portion of the 1988 Salem Nuclear Generating Station Emergency Exercise. The purpose of this phase of the exercise was to demonstrate the ingestion pathway components of the State's Radiological Emergency Response Plan (RERP) to the Federal Emergency Management Agency (FEMA). The intent of this paper is to provide a summary of difficulties and some lessons learned in implementing the DEP's ingestion pathway Protective Action Guides (PAGs) during the exercise as well as during the preparation of a total population dose estimate (TPDE)

New Jersey's experience with implementing Protective Action Guides during the 1988 Salem ingestion pathway exercise

Energy Technology Data Exchange (ETDEWEB)

White, Duncan [New Jersey Department of Environmental Protection, Trenton, NJ (United States)

1989-09-01

On November 30 and December 1, 1988, the New Jersey Department of Environmental Protection (DEP) and three other State agencies (Health, Agriculture and State Police) participated in the ingestion pathway portion of the 1988 Salem Nuclear Generating Station Emergency Exercise. The purpose of this phase of the exercise was to demonstrate the ingestion pathway components of the State's Radiological Emergency Response Plan (RERP) to the Federal Emergency Management Agency (FEMA). The intent of this paper is to provide a summary of difficulties and some lessons learned in implementing the DEP's ingestion pathway Protective Action Guides (PAGs) during the exercise as well as during the preparation of a total population dose estimate (TPDE)

Assessment of the impacts of the Salem and Hope Creek Stations on shortnose sturgeon, 'Acipenser brevirostrum' lesueur. Technical report

International Nuclear Information System (INIS)

Masnik, M.T.; Wilson, J.H.

1980-04-01

Acipenser brevirostrum, a federally recognized endangered species, is known from the Delaware River in the vicinity of the Salem and Hope Creek Nuclear Stations. The potential for adverse impact to this species due to the completion of construction and the operation of these stations is assessed. A review of the literature pertaining to the distribution, life history, and tolerance of this species is presented. Both historical records and current status of the shortnose sturgeon population in the Delaware River are discussed

Selected elements and organic chemicals in streambed sediment in the Salem area, Oregon, 1999

Science.gov (United States)

Tanner, Dwight Q.

2002-09-13

Analysis of streambed sediments in the Salem, Oregon, area showed anomalously large concentrations of some elements and organic chemicals, indicating contamination from anthropogenic and/or geologic sources. The streambed sediment sample from Clark Creek, an urban basin, had large concentrations of polycyclic aromatic hyrdocarbons (PAHs), organochlorines, cadmium, lead, and zinc. The sample from the East Fork of Pringle Creek, which is a mostly urban basin, had the highest concentrations of DDD, DDE, and DDT compounds. Aldrin was detected in streambed sediment at only one site, the East Fork of Pringle Creek. Ten of the 14 sites sampled had exceedances of the sediment quality guidelines of the Canadian Council of Ministers of the Environment (CCME), and 8 sites had exceedances of guidelines from the Puget Sound Dredged Disposal Analysis (PSDDA) Program.

Generic implications of ATWS events at the Salem Nuclear Power Plant. Licensee and staff actions

International Nuclear Information System (INIS)

1983-08-01

This report, Volume 2 of two volumes of NUREG-1000, describes the intermediate term actions to be taken by licensees and applicants of the US Nuclear Regulatory Commission (NRC), on the one hand, and by NRC staff, on the other, to address the generic issues raised by two anticipated transients without scram (ATWS) at the Salem Nuclear Generating Station, Unit 1, on February 22 and 25, 1983. These actions came about as a result of the findings of NUREG-1000, Volume 1, and of reviews by the NRC Committee to Review Generic Requirements, the NRC Program Offices, and the Commission. The actions to be taken by licensees and applicants have been detailed in a letter pursuant to 10 CFR 50.54(f)

Microbial Beneficiation of Salem Iron Ore Using Penicillium purpurogenum

Science.gov (United States)

Mishra, M.; Pradhan, M.; Sukla, L. B.; Mishra, B. K.

2011-02-01

High alumina and silica content in the iron ore affects coke rate, reducibility, and productivity in a blast furnace. Iron ore is being beneficiated all around the world to meet the quality requirement of iron and steel industries. Choosing a beneficiation treatment depends on the nature of the gangue present and its association with the ore structure. The advanced physicochemical methods used for the beneficiation of iron ore are generally unfriendly to the environment. Biobeneficiation is considered to be ecofriendly, promising, and revolutionary solutions to these problems. A characterization study of Salem iron ore indicates that the major iron-bearing minerals are hematite, magnetite, and goethite. Samples on average contains (pct) Fe2O3-84.40, Fe (total)-59.02, Al2O3-7.18, and SiO2-7.53. Penicillium purpurogenum (MTCC 7356) was used for the experiment . It removed 35.22 pct alumina and 39.41 pct silica in 30 days in a shake flask at 10 pct pulp density, 308 K (35 °C), and 150 rpm. In a bioreactor experiment at 2 kg scale using the same organism, it removed 23.33 pct alumina and 30.54 pct silica in 30 days at 300 rpm agitation and 2 to 3 l/min aeration. Alumina and silica dissolution follow the shrinking core model for both shake flask and bioreactor experiments.

Technical evaluation of the electrical, instrumentation, and control design aspects of the low temperature overpressure protection system for the Salem nuclear power plant, Unit 1

International Nuclear Information System (INIS)

Laudenbach, D.H.

1979-03-01

The technical evaluation is presented for the electrical, instrumentation, and control design aspects of the low temperature overpressure protection system for the Salem nuclear power plant, Unit 1. Design basis criteria used to evaluate the acceptability of the system include operator action, system testability, single failure criterion, and seismic Category I and IEEE Std-279-1971 criteria

Downthrown traps of the NW Witch Ground Graben, UK North Sea

Energy Technology Data Exchange (ETDEWEB)

Hindle, A.D. (Texaco Ltd., London (GB))

1989-10-01

The structures drilled to-date in the NW Witch Ground Graben area have been assigned to two broad categories: upthrown traps with four-way dip closure or tilted fault blocks, generally located on the flanks of the graben; and downthrown traps with closure against a major fault, located downthrown on the main graben border-fault systems. Many of these are in fact combination traps, having upthrown fault-seal and/or stratigraphic elements. A study of trap settings has shown: the success rate for encountering hydrocarbons in upthrown traps and downthrown traps is very similar; the common belief that the footwall seal is the most critical element of a downthrown trap is questionable; modern seismic data reveals that a high proportion of unsuccessful exploratory wells were not located on a closed structure; there is a lesser chance of the reservoir being absent, or there being no migration route to the trap, in downthrown compared with upthrown structures; carboniferous sediments can be a footwall seal for a downthrown trap in one location, and a reservoir for hydrocarbons in another; the structural evolution of the Graben has been ideal for the development of downthrown traps. (author).

Phenolic compounds, methylxanthines and antioxidant activity in cocoa mass and chocolates produced from "witch broom disease" resistant and non resistant cocoa cultivars

OpenAIRE

Leite,Paula Bacelar; Maciel,Leonardo Fonseca; Opretzka,Luiza Carolina França; Soares,Sergio Eduardo; Bispo,Eliete da Silva

2013-01-01

The "witch broom disease" caused by the fungus called Moniliophthora perniciosa is one of the most important cocoa diseases in Latin America, causing around 70% production reduction in the southern Bahia. In attempt to solve the problem, many cultivars resistant to the disease have been recommended to farmers. On the other hand, the chocolate flavour is composed by many compounds whose formation depends on the genetic background, environment where cocoa is grown and processing operations. The...

The Association between Cariogenic Factors and the Occurrence of Early Childhood Caries in Children from Salem District of India.

Science.gov (United States)

Stephen, Arokiaraj; Krishnan, Ramesh; Chalakkal, Paul

2017-07-01

Various aetiological factors for Early Childhood Caries (ECC) have been suggested in literature, but the role of each factor has been disputed in various studies. To evaluate the association between ECC and its related factors in children between three to six years of age, from rural, semi-urban and urban schools in the district of Salem (India). The study consisted of children between three to six years of age, selected randomly from schools in semi-urban, urban and rural schools at Salem. Questionnaire (comprising of the factors associated with ECC) and parental consent forms were sent to each of the parents of the school children. Filled questionnaires and parental consent forms were obtained from a total of 2771 children, out of which 1771 were boys and 1000 were girls. Clinical examination for ECC was carried out according to the WHO criteria, by a single examiner and an assistant to eliminate inter-examiner variability. Statistical analysis was carried out using the student's independent t-test and ANOVA (one way analysis of variance). Out of a total of 2771 children examined, only 443 (315 boys and 128 girls) children were found to have ECC (16 %). Significant correlations were found between the occurrence of ECC and various factors like age of parents, number of siblings, on-demand breast feeding and bottle feeding habits and sweetened pacifier use. However, factors such as age and gender of the child, type of birth and duration of pregnancy, had no significant correlation with the occurrence of ECC. The need for educating parents on the ill effects of improper breast feeding and bottle feeding habits is important.

Characterisation in Ward’s opera The Crucible: melodic interpretation of Salem’s witches and their accusers via historical accounts and Miller’s play

OpenAIRE

Cornwell McKean, Julia Margaret

2017-01-01

ABSTRACT Characterisation in Ward’s opera The Crucible: Melodic interpretation of Salem’s witches and their accusers via historical accounts and Miller’s play This thesis is a consideration of the transition of the characters of Robert Ward’s opera The Crucible from history through to Arthur Miller’s play of the same name, and finally to the linear elements of the opera: the libretto and the vocal melodies. Arthur Miller’s The Crucible (1953) is widely known as a play that explor...

Groundwater resource exploration in Salem district, Tamil Nadu using GIS and remote sensing

Science.gov (United States)

Maheswaran, G.; Selvarani, A. Geetha; Elangovan, K.

2016-03-01

Since last decade, the value per barrel of potable groundwater has outpaced the value of a barrel of oil in many areas of the world. Hence, proper assessment of groundwater potential and management practices are the needs of the day. Establishing relationship between remote sensing data and hydrologic phenomenon can maximize the efficiency of water resources development projects. Present study focuses on groundwater potential assessment in Salem district, Tamil Nadu to investigate groundwater resource potential. At the same, all thematic layers important from ground water occurrence and movement point of view were digitized and integrated in the GIS environment. The weights of different parameters/themes were computed using weighed index overlay analysis (WIOA), analytic hierarchy process (AHP) and fuzzy logic technique. Through this integrated GIS analysis, groundwater prospect map of the study area was prepared qualitatively. Field verification at observation wells was used to verify identified potential zones and depth of water measured at observation wells. Generated map from weighed overlay using AHP performed very well in predicting the groundwater surface and hence this methodology proves to be a promising tool for future.

Generic implications of ATWS events at the Salem Nuclear Power Plant: generic implications. Vol. 1

International Nuclear Information System (INIS)

1983-04-01

This report is the first of two volumes. It documents the work of an interoffice, interdisciplinary NRC Task Force established to determine the generic implications of two anticipated transients without scram (ATWS) at the Salem Nuclear Power Plant, Unit 1 on February 22 and 25, 1983. A second report will document the NRC actions to be taken based on the work of the Task Force. The Task Force was established to address three questions: (1) Is there a need for prompt action for similar equipment in other facilities. (2) Are NRC and its licensees learning the sefety-management lessons, and, (3) How should the priority and content of the ATWS rule be adjusted. A number of short-term actions were taken through Bulletins and an Information Notice. Intermediate-term actions to address the generic issues will be addressed in the separate report and implemented through appropriate regulatory mechanisms

NRC Fact-Finding Task Force report on the ATWS event at Salem Nuclear Generating Station, Unit 1, on February 25, 1983

International Nuclear Information System (INIS)

1983-03-01

An NRC Region I Task Force was established on March 1, 1983 to conduct fact finding and data collection with regard to the circumstances which led to an anticipated transient without scram (ATWS) event at the Public Service Electric and Gas Company's Salem Generating Station, Unit 1 on February 25, 1983. The charter of the Task Force was to determine the factual information pertinent to management and administrative controls which should have ensured proper operation of the reactor trip breakers in the solid state protection system. This report documents the findings of the Task Force along with its conclusions

El estreno de Las brujas de Salem en el teatro español de Madrid (1956-1957

Directory of Open Access Journals (Sweden)

Gil Fombellida, M. Carmen

2002-06-01

Full Text Available In 1956, the director of the Español theatre, José Tamayo, decided to stage this play by Arthur Miller, backed by the warm welcome on the part of the audience, by the critics that other works from the same author had received, such as, for example. Death of a salesman, which had also been directed by Tamayo in 1952, as well as by the increasing interest that Miller's theatrical proposals arose during the 50s. The political situation at that moment, the censorship and the general public's tastes marked the debut of The Crucible (Las brujas de Salem at Madrid's stages. The artistic proposal by Tamayo turned out as risky as the ideological one, mostly taking into account that the plays that were succeeding at that moment were musical comedies and revues. Against all odds, the play situated among one of the most watched ones and one that created most expectation among specialised columnists of the time. An analysis of the numerous critics that appeared after its presentation explains the curiosity that this setup originated, as well as the reasons for its success: the ideological connotations of the play, the quality of its adaptation, its spectacular staging and the work carried out by most actors and actresses, all which justified the great welcome on the part of spectators and the running of the play until performance number 99 was reached.En 1956, el director del teatro Español de Madrid, José Tamayo, decidió poner en escena el drama de Arthur Miller, La brujas de Salem (The Crucible, respaldado por la gran acogida de los espectadores y la crítica hacia otros de los textos del escritor norteamericano. La muerte de un viajante, dirigido también por Tamayo en 1952, y por el creciente interés que las propuestas escénicas de Miller despertaron durante la década de los cincuenta. Las circunstancias políticas del momento, la censura y los gustos del gran público marcaron el estreno de Las brujas de Salem en los escenarios madrileños. La

O paraíso não é aqui: a violência contra a mulher emTatiana Salem Levy

Directory of Open Access Journals (Sweden)

Paula Queiroz Dutra

2016-01-01

Full Text Available Este trabajo tiene como objetivo analizar las representaciones de las distintas formas de violencia contra la mujer en la novela Paraíso (2014, de la escritora brasileña Tatiana Salem Levy. Se busca comprender y problematizar la representación del dolor del otro y del posicionamiento de las mujeres frente a situaciones de violencia dentro de la novela. Además, se pretende observar si la representación de la violencia sufrida por los personajes femeninos, tanto en el espacio público como en el doméstico, contribuye a una crítica a la violencia contra la mujer, deconstruyendo estereotipos de sumisión y victimización.

Identification of genes related to Paulownia witches' broom by AFLP and MSAP.

Science.gov (United States)

Cao, Xibing; Fan, Guoqiang; Deng, Minjie; Zhao, Zhenli; Dong, Yanpeng

2014-08-21

DNA methylation is believed to play important roles in regulating gene expression in plant growth and development. Paulownia witches' broom (PaWB) infection has been reported to be related to gene expression changes in paulownia plantlets. To determine whether DNA methylation is associated with gene expression changes in response to phytoplasma, we investigated variations in genomic DNA sequence and methylation in PaWB plantlets treated with methyl methane sulfonate (MMS) using amplified fragment length polymorphism (AFLP) and methylation-sensitive amplification polymorphism (MSAP) techniques, respectively. The results indicated that PaWB seedings recovered a normal morphology after treatment with more than 15 mg·L(-1) MMS. PaWB infection did not cause changes of the paulownia DNA sequence at the AFLP level; However, DNA methylation levels and patterns were altered. Quantitative real-time PCR (qRT-PCR) showed that three of the methylated genes were up-regulated and three were down-regulated in the MMS-treated PaWB plantlets that had regained healthy morphology. These six genes might be involved in transcriptional regulation, plant defense, signal transduction and energy. The possible roles of these genes in PaWB are discussed. The results showed that changes of DNA methylation altered gene expression levels, and that MSAP might help identify genes related to PaWB.

Behavior of many ions in a Penning trap and results of the WITCH experiment

CERN Document Server

Porobic, Tomica

Precision measurements of the beta−neutrino angular correlation in nuclear beta-decay provide a unique window into the physics beyond the Standard model. The WITCH (Weak Interaction Trap for CHarged particles) experiment aims to measure this correlation, a(beta-nu), in order to impose a more stringent constraint on the exotic scalar current admixture in the beta-decay Hamiltonian. The apparatus is situated at CERN/ISOLDE laboratory and consists of a unique combination of a retardation spectrometer and two Penning traps, with one of them serving as a scattering-free source. This configuration is suited for a precise measurement of the energy spectrum of 35Ar recoiled daughter ions. The shape of the spectrum then allows a determination of a(beta-nu) and consequently of the presence or absence of a scalar current. Radioactive 35Ar ions are created at ISOLDE by impinging 1.2 GeV protons on the target material. After being separated by a magnetic separator and bunched by REXTRAP, a high-capacity Penning trap, th...

Science and the Detective: Selected Reading in Forensic Science

Science.gov (United States)

Kaye, Brian H.

1996-12-01

Who killed Napoleon? Were the witches of Salem high on LSD? What do maggots on a body tell us about the time of death? In his unique, engaging style, Brian Kaye tells the story of some spectacular cases in which forensic evidence played a key role. You'll also read about the fascinating ways in which scientific evidence can be used to establish guilt or innocence in today's courtroom. The use of voice analysis, methods for developing fingerprints and for uncovering art forgeries, and the examination of bullet wounds are just a few topics considered. In a special section on fraud, the author takes you into the world of counterfeit money. There's no solving crime without science. Written for everyone interested in whodunnits, this book explains the basis of the analytical techniques available for studying evidence in offenses ranging from doping in sports to first-degree murder.

The Salem Smart Power Center: An Assessment of Battery Performance and Economic Potential

Energy Technology Data Exchange (ETDEWEB)

Balducci, Patrick J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Alam, M. J.E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Viswanathan, Vilayanur [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wu, Di [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Crawford, Aladsair J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mongird, Kendall [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Weimar, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Somani, Abhishek [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Whitener, Kevin [Portland General Electric, OR (United States)

2017-09-21

This paper presents an assessment of the economic potential of a 5 MW/1.25 MWh Energy Storage System (ESS) installed at the Salem Smart Power Center (SSPC), a smart grid technology demonstration facility owned and operated by Portland General Electric (PGE) in Salem, Oregon. The ESS and the grid conditions in which it operates were modeled using Pacific Northwest National Laboratory’s Battery Storage Evaluation Tool (BSET) to explore tradeoffs between services, and to develop optimal control strategies. This assessment monetized the value derived from nine services the SSPC could provide to PGE and the customers it serves. The ESS and the grid conditions in which it operates were modeled using PNNL’s in-house optimization tool BSET to explore tradeoffs between services, and to develop optimal control strategies. The analysis resulted in a number of lessons that provide crucial insights into the practical application of ESS, including; The SSPC, which was originally conceived as a research and test facility and built with the prevailing maturity technology level, was built at a cost ($20.4 million) that exceeds current day prices ($5.4 million) for a similarly designed and built 5 MW/1.25 MWh system; In terms of economic operation, the SSPC is currently underutilized, deployed only for primary frequency response. PNNL modeling indicates that optimal operation of the ESS could generate an additional value of $2.3 million over 20 years. It should also be noted that primary frequency response is the highest benefit application but requires a response from the SSPC only 17 hours each year. While optimally engaged, the ESS would provide arbitrage and ancillary services 78 percent of the time, but those services generate only 27 percent of the total value; Participation in Western EIM represents an interesting opportunity for PGE with a potential to generate $2.1 million value in PV terms over 20 years in the 5-min real-time market; With an energy to power ratio of

Prevalence of Oral Mucosal Lesions among Dental Patients with Mixed Habits in Salem District - A Study

Science.gov (United States)

Karthik, R.; Mohan, N.

2017-01-01

Background: The practice of betel nut chewing with or without tobacco is still practiced in south india, salem inspite of its harmful effects. Methodology: 200 Patients visiting the outpatient department, Oral medicine and radiology from Aug 2015 to Aug 2016. Result and Conclusion: In our study, 3 women were exclusively churut smokers. Thirty-eight percent of the dental patients were beedi smoker, 32% were tobacco chewers, 12% were both betel nut and tobacco chewers, 8% were exclusively betel nut chewers, 1% of the dental population were exclusively churut smokers. Mean age group of the study population is 50.2 (14.4). There are 28 females and 172 males in the study group. Chi-square test revealed a statistically significant difference (P = 0.001) between males and females based on soft-tissue findings and no statistically significant difference (P = 0.572) between males and females based on distribution of hard-tissue findings. PMID:29284937

Cacao Phylloplane: The First Battlefield against Moniliophthora perniciosa, Which Causes Witches' Broom Disease.

Science.gov (United States)

Almeida, D S M; Gramacho, K P; Cardoso, T H S; Micheli, F; Alvim, F C; Pirovani, C P

2017-07-01

The phylloplane is the first contact surface between Theobroma cacao and the fungus Moniliophthora perniciosa, which causes witches' broom disease (WBD). We evaluated the index of short glandular trichomes (SGT) in the cacao phylloplane and the effect of irrigation on the disease index of cacao genotypes with or without resistance to WBD, and identified proteins present in the phylloplane. The resistant genotype CCN51 and susceptible Catongo presented a mean index of 1,600 and 700 SGT cm -2 , respectively. The disease index in plants under drip irrigation was reduced by approximately 30% compared with plants under sprinkler irrigation prior to inoculation. Leaf water wash (LWW) of the cacao inhibited the germination of spores by up to 98%. Proteins from the LWW of CCN51 were analyzed by two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis followed by tandem mass spectrometry. The gel showed 71 spots and identified a total of 42 proteins (28 from the plant and 14 from bacteria). Proteins related to defense and synthesis of defense metabolites and involved in nucleic acid metabolism were identified. The results support the hypothesis that the proteins and water-soluble compounds secreted to the cacao phylloplane participate in the defense against pathogens. They also suggest that SGT can contribute to the resistance of cacao.

Production of hydrolytic enzymes by Trichoderma isolates with antagonistic activity against Crinipellis perniciosa, the causal agent of witches' broom of cocoa

Directory of Open Access Journals (Sweden)

Marco Janice Lisboa De

2003-01-01

Full Text Available Two isolates of Trichoderma, which reduce the incidence of witches'broom disease caused in cocoa by Crinipellis perniciosa, were evaluated for their potential to produce hydrolases in liquid medium. Very low or no hydrolytic activity was produced in the absence of any substrate. The activities of chitinase, N-acetylglucosaminidase, beta-1,3-glucanase, total cellulase, endoglucanase, aryl- beta-glucosidase, beta-glucosidase, protease and amylase increased dramatically within 72-120 h of growth in the presence of specific substrates. Except for N-acetylglucosaminidase and beta-glucosidase Trichoderma harzianum isolate 1051 produced the largest amounts of hydrolases. The possible involvement of these enzymes in the antagonistic interaction between Trichoderma and C. perniciosa is discussed.

Petrology and geochemistry of dolerite dykes of Dharmapuri and Salem districts of Tamil Nadu

International Nuclear Information System (INIS)

Jayabalan, M.; Umamaheswaran, O.; Suresh, A.

2012-01-01

Dolerite dyke sets occur distributed in the Dharmapuri and Salem districts of northern Tamil nadu. These dykes have been emplaced in the older basement composed of granulite and gneissic rocks and cut across the later formed lineament controlled alkaline complexes. They are composed of medium to coarse calcic plagioclase and clinopyroxene with biotite, amphibole, uralite, olivine, orthopyroxene, and anhedral quartz as accessories. Based on geochemical characters, the olivine bearing dykes are classed as Type I and the quartz bearing dykes as Type II. The Type I dykes resemble basalt and the Type II dykes, basaltic andesite. They display LILE> HFSE in terms of abundance. The REE values indicate enrichment of LREE relative to MREE and HREE and an E-MORB or Plume MORB signature. The geochemistry of the sampled dykes suggests derivation from a mantle plume. This plume was emplaced into the garnet lherzolite layer and subsequently into the shallower spinel lherzolite layer in the mantle. Polybaric melting of lherzolite protoliths with varying proportions of garnet and spinel occurred with subsequent fractionation to produce a source melts with E-MORB characteristics. Emplacement of these dykes was aided by crustal extension and associated fracturing to develop a dyke swarm. (author)

Marcadores microssatélites relacionados com a resistência à vassoura-de-bruxa do cacaueiro Microsatellite markers related to resistance of cocoa tree against witches'-broom

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Rogério Mercês Ferreira Santos

2007-08-01

Full Text Available Os objetivos deste trabalho foram caracterizar a resistência à vassoura-de-bruxa de plantas de cacau originadas do cruzamento entre TSH 1188 e CCN 51 (população segregante, por meio de dois métodos de inoculação em condições de campo, e identificar marcadores microssatélites específicos para grupos de plantas resistentes e suscetíveis. As plantas-controle avaliadas pelos métodos de inoculação natural e inoculação artificial em campo produziram os mesmos padrões de sintomas. As plantas da população segregante também coincidiram os padrões de sintomas em 90%, por esses dois métodos. O método de inoculação artificial em campo permite detectar falso-resistentes. Dos 18 pares de primers microssatélites amplificados, 15 foram polimórficos entre os genitores, e seis entre os grupos de plantas segregantes contrastantes quanto à resistência à vassoura-de-bruxa. Foram confirmadas três marcas previamente associadas a QTL (locos para características quantitativas relacionados com a resistência à vassoura-de-bruxa, comuns a outras populações. Também foram identificados três novos QTL para esta característica, típicos desta população, o que comprova sua utilidade para o melhoramento genético do cacaueiro.The objectives of this work were to evaluate cocoa tree resistance against witches'-broom, in plants originated from the crossing between TSH 1188 and CCN 51 (segregating population, by means of two methods of inoculation in field conditions, and to identify microsatellite markers specific for resistant and susceptible plants. The control plants bore identical symptoms as the plants of the segregating population in 90% of the cases under the two methods. The method of artificial inoculation in the field allows the detection of false resistance to the disease. Of the 18 pairs of microsatellite primers amplified, 15 were polymorphic between genitors and six were polymorphic between the two groups of plants evaluated

Superfund Record of Decision (EPA Region 2): NL Industries, Salem County, Pedricktown, NJ. (First remedial action), September 1991

Energy Technology Data Exchange (ETDEWEB)

1991-09-27

The 44-acre NL Industries site is an inactive, secondary lead smelting facility in Pedricktown, Salem County, New Jersey. The site overlies the Cape May aquifer, a potential source of drinking water for local residents. In 1989, EPA began a multi-phased removal action. The Focused Feasibility Study resulted in the issuance of the Early Remedial Action Record of Decision (ROD), designated as Operable Unit (OU2). The nature and extent of remaining contamination on the site and areas adjacent to the site in various environmental media, such as soil, sediment, ground water, surface water, and air, are currently being evaluated and will be addressed as OU1 in a subsequent ROD. The primary contaminants of concern affecting the slag and lead oxide piles, sediment, debris, and standing surface water are metals including arsenic, chromium, and lead. The selected remedial action for the site is included.

Survey of Leafhopper Species in Almond Orchards Infected with Almond Witches'-Broom Phytoplasma in Lebanon

Science.gov (United States)

Hammad, Efat Abou-Fakhr; El-Mohtar, Choaa; Abou-Jawdah, Yusuf

2011-01-01

Leafhoppers (Hemiptera: Auchenorrhyncha: Cicadellidae) account for more than 80% of all “Auchenorrhynchous” vectors that transmit phytoplasmas. The leafhopper populations in two almond witches'-broom phytoplasma (AlmWB) infected sites: Tanboureet (south of Lebanon) and Bourj El Yahoudieh (north of Lebanon) were surveyed using yellow sticky traps. The survey revealed that the most abundant species was Asymmetrasca decedens, which represented 82.4% of all the leafhoppers sampled. Potential phytoplasma vectors in members of the subfamilies Aphrodinae, Deltocephalinae, and Megophthalminae were present in very low numbers including: Aphrodes makarovi, Cicadulina bipunctella, Euscelidius mundus, Fieberiella macchiae, Allygus theryi, Circulifer haematoceps, Neoaliturus transversalis, and Megophthalmus scabripennis. Allygus theryi (Horváth) (Deltocephalinae) was reported for the first time in Lebanon. Nested PCR analysis and sequencing showed that Asymmetrasca decedens, Empoasca decipiens, Fieberiella macchiae, Euscelidius mundus, Thamnottetix seclusis, Balclutha sp., Lylatina inexpectata, Allygus sp., and Annoplotettix danutae were nine potential carriers of AlmWB phytoplasma. Although the detection of phytoplasmas in an insect does not prove a definite vector relationship, the technique is useful in narrowing the search for potential vectors. The importance of this information for management of AlmWB is discussed. PMID:21864154

Lithological mapping of Kanjamalai hill using hyperspectral remote sensing tools in Salem district, Tamil Nadu, India

Science.gov (United States)

Arulbalaji, Palanisamy; Balasubramanian, Gurugnanam

2017-07-01

This study uses advanced spaceborne thermal emission and reflection radiometer (ASTER) hyperspectral remote sensing techniques to discriminate rock types composing Kanjamalai hill located in the Salem district of Tamil Nadu, India. Kanjamalai hill is of particular interest because it contains economically viable iron ore deposits. ASTER hyperspectral data were subjected to principal component analysis (PCA), independent component analysis (ICA), and minimum noise fraction (MNF) to improve identification of lithologies remotely and to compare these digital data results with published geologic maps. Hyperspectral remote sensing analysis indicates that PCA (R∶G∶B=2∶1∶3), MNF (R∶G∶B=3∶2∶1), and ICA (R∶G∶B=1∶3∶2) provide the best band combination for effective discrimination of lithological rock types composing Kanjamalai hill. The remote sensing-derived lithological map compares favorably with a published geological map from Geological Survey of India and has been verified with ground truth field investigations. Therefore, ASTER data-based lithological mapping provides fast, cost-effective, and accurate geologic data useful for lithological discrimination and identification of ore deposits.

Self-reported adherence and biomarker levels of CoQ10 and alpha-tocopherol

Directory of Open Access Journals (Sweden)

Vitolins MZ

2018-04-01

Full Text Available Mara Z Vitolins,1 L Douglas Case,1 Stephen R Rapp,2 Mark O Lively,3 Edward G Shaw,4 Michelle J Naughton,5 Jeffrey Giguere,6 Glenn J Lesser7 1Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA; 4Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Internal Medicine, The Ohio State University, Columbus, OH, USA; 6Greenville Community Oncology Research Program of the Carolinas, Greenville, SC, USA; 7Department of Internal Medicine-Hematology and Oncology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA Purpose: Women with breast cancer were randomized to receive coenzyme Q10 (CoQ10 plus Vitamin E or placebo in a clinical trial. The objective of this evaluation is to examine the association between participant self-reported adherence to the study supplements and changes in plasma biomarker levels.Patients and methods: Correlation coefficients quantified the association between changes in alpha-tocopherol and CoQ10 levels and the association between self-reported adherence and changes in biomarkers. Participants were categorized by self-reported adherence; Kruskal–Wallis tests compared changes in alpha-tocopherol and CoQ10 levels between self-reported adherence groups.Results: Women (N=155 provided baseline and post-treatment biomarkers; 147 completed at least one diary. While changes in alpha-tocopherol and CoQ10 levels were moderately correlated, correlations ranged from 0.40 to 0.48, association between self-reported adherence and plasma alpha-tocopherol or CoQ10 levels was weak; correlations ranged from 0.10 to 0.29 at weeks 8, 16, and 24. Some participants with high self-reported adherence actually

Analytical characterization of radiation fields generated by certain witch-type distributed axi-symmetrical ion beams

International Nuclear Information System (INIS)

Timus, D.M.; Kalla, S.L.; Abbas, M.I.

2005-01-01

Increasing interest is being shown in obtaining accurate predictions concerning radiation fields produced by ion beams impinging on homogeneous plane targets, the effect of this process being exothermic nuclear reactions. Previous theoretical studies made by the authors have focused on radiation fields generated by homogeneous plane disk- or ring-shaped sources, based on a unified treatment of the radiation field distribution developed by Hubbell and co-workers. In the case of an equivalent homogeneous source anisotropically emitting in non dispersive media, the Legendre polynomial series expansion method for specific emissivity function can be successfully applied when conditions for the convergence of the approximating series are satisfied. We have developed an analytical expression for the radiation field distribution around a homogeneous disk-shaped target bombarded by Witch-type distributed (in transverse plane) ion beams whose elementary areas anisotropically emit following a cos-type law in non dispersive media. Results of this investigation can be extended to various experimental situations in which the assumption of an angular omni-directional as well as of a constant space distribution of nuclear reaction emissivity over the accelerator target surface or other kinds of axi-symmetric plane sources of radiation is no longer valid. Animated 3 D graphics visualization is suggested

Morphological changes of Paulownia seedlings infected phytoplasmas reveal the genes associated with witches' broom through AFLP and MSAP.

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Xibing Cao

Full Text Available Paulownia witches' broom (PaWB caused by phytoplasma might result in devastating damage to the growth and wood production of Paulownia. To study the effect of phytoplasma on DNA sequence and to discover the genes related to PaWB occurrence, DNA polymorphisms and DNA methylation levels and patterns in PaWB seedlings, the ones treated with various concentration of methyl methane sulfonate (MMS and healthy seedlings were investigated with amplified fragment length polymorphism (AFLP and methylation-sensitive amplification polymorphism (MSAP. Our results indicated that PaWB seedlings recovered a normal morphology, similar to healthy seedlings, after treatment with more than 20 mg · L-1 MMS; Phytoplasma infection did not change the Paulownia genomic DNA sequence at AFLP level, but changed the global DNA methylation levels and patterns; Genes related to PaWB were discovered through MSAP and validated using quantitative real-time PCR (qRT-PCR. These results implied that changes of DNA methylation levels and patterns were closely related to the morphological changes of seedlings infected with phytoplasmas.

Parent selection for cocoa resistance to witches'-broom Seleção de progenitores de cacaueiro quanto à resistência à vassoura-de-bruxa

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Stela Dalva Vieira Midlej Silva

2010-07-01

Full Text Available The objective of this work was to identify genotypes with high general combining ability for resistance to witches'-broom (Moniliophthora perniciosa in populations formed from a first cycle of recurrent selection. Highly productive and resistant clones from different origins were interbred using the North Carolina II design. The clones SCA 6, CSUL 7, RB 39, CEPEC 89, OC 67, BE 4, EEG 29 and ICS 98 were used as paternal parents, while the maternal ones were NA 33, CCN 10, IMC 67, P 4B, CCN 51, CEPEC 86, SGU 54 and ICS 9. Twenty days after germination, 56 seedlings of each cross (four replicates of 14 seedlings received the inoculation of a 1-mL suspension with 7.5x10(4 basidiospores mL-1. Symptoms were evaluated 60 days after inoculation. Significant differences were observed among paternal and among maternal parents, for resistance to witches'-broom assessed according to the proportion of progeny seedlings with the disease symptoms. Differences were also observed between groups of mothers or fathers previously defined as resistant, and groups previously defined as susceptible. It is possible to obtain a combination of genes that can increase the level of resistance to witches'-broom directly from the first cycle of recurrent selection.O objetivo deste trabalho foi identificar genótipos com alta capacidade geral de combinação quanto à resistência à vassoura-de-bruxa (Moniliophthora perniciosa, em populações formadas a partir do primeiro ciclo de seleção recorrente. Clones altamente produtivos e resistentes à vassoura-de-bruxa, de diferentes procedências, foram intercruzados com uso do delineamento Carolina do Norte II. Como progenitores paternos, foram utilizados os clones SCA 6, CSUL 7, RB 39, CEPEC 89, OC 67, BE 4, EEG 29 e ICS 98 e, como maternos, NA 33, CCN 10, IMC 67, P 4B, CCN 51, CEPEC 86, SGU 54 e ICS 9. Vinte dias após a germinação, 56 plântulas de cada cruzamento (quatro repetições de 14 plântulas receberam inocula

Apoplastic and intracellular plant sugars regulate developmental transitions in witches' broom disease of cacao.

Science.gov (United States)

Barau, Joan; Grandis, Adriana; Carvalho, Vinicius Miessler de Andrade; Teixeira, Gleidson Silva; Zaparoli, Gustavo Henrique Alcalá; do Rio, Maria Carolina Scatolin; Rincones, Johana; Buckeridge, Marcos Silveira; Pereira, Gonçalo Amarante Guimarães

2015-03-01

Witches' broom disease (WBD) of cacao differs from other typical hemibiotrophic plant diseases by its unusually long biotrophic phase. Plant carbon sources have been proposed to regulate WBD developmental transitions; however, nothing is known about their availability at the plant-fungus interface, the apoplastic fluid of cacao. Data are provided supporting a role for the dynamics of soluble carbon in the apoplastic fluid in prompting the end of the biotrophic phase of infection. Carbon depletion and the consequent fungal sensing of starvation were identified as key signalling factors at the apoplast. MpNEP2, a fungal effector of host necrosis, was found to be up-regulated in an autophagic-like response to carbon starvation in vitro. In addition, the in vivo artificial manipulation of carbon availability in the apoplastic fluid considerably modulated both its expression and plant necrosis rate. Strikingly, infected cacao tissues accumulated intracellular hexoses, and showed stunted photosynthesis and the up-regulation of senescence markers immediately prior to the transition to the necrotrophic phase. These opposite findings of carbon depletion and accumulation in different host cell compartments are discussed within the frame of WBD development. A model is suggested to explain phase transition as a synergic outcome of fungal-related factors released upon sensing of extracellular carbon starvation, and an early senescence of infected tissues probably triggered by intracellular sugar accumulation. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology.

NURE aerial gamma-ray and magnetic reconnaissance survey: Blue Ridge area, Greensboro NJ 17-12, Winston-Salem NJ 17-11, and Johnson City NJ 17-10 Quadrangles. Volume I. Narrative report

International Nuclear Information System (INIS)

1978-12-01

As part of the Department of Energy (DOE) National Uranium Resource Evaluation (NURE) Program, LKB Resources, Inc. has performed a rotary-wing, reconnaissance high sensitivity radiometric and magnetic survey in the Blue Ridge area of Virginia, North Carolina, South Carolina, Kentucky, and Tennessee. Five (5) 1:250,000 scale NTMS quadrangles (Greensboro, Winston-Salem, Johnson City, Knoxville, and Charlotte) were surveyed. A total of 15,753 line miles (25,347 kilometers) of data were collected utilizing a Sikorsky S58 and S58T helicopter. Traverse lines were flown in an east-west direction at 3.0 mile (4.8 kilometer) spacing, with tie lines flown in a north-south direction at 12 mile (20 kilometer) spacing. The data were digitally recorded at 1.0 second intervals. The NaI terrestrial detectors used in this survey had a total volume of 2,154 cubic inches. The magnetometer employed was a modified ASQ-10 fluxgate system. This report covers the Greensboro, Winston-Salem, and Johnson City NTMS 1:250,000 scale quadrangles. The Knoxville and Charlotte NTMS 1:250,000 scale quadrangles are covered in a separate report. The radiometric data were normalized to 400 feet terrain clearance, and are presented in the form of computer listings on microfiche and as stacked profile plots. Profile plots are contained in Volume II of this report. A geologic interpretation of the radiometric and magnetic data is included as part of this report

The causal agents of witches' broom and frosty pod rot of cacao (chocolate, Theobroma cacao) form a new lineage of Marasmiaceae.

Science.gov (United States)

Aime, M C; Phillips-Mora, W

2005-01-01

The two most devastating diseases of cacao (Theobroma cacao)--the source of chocolate--in tropical America are caused by the fungi Crinipellis perniciosa (witches' broom disease) and Moniliophthora roreri (frosty pod rot or moniliasis disease). Despite the agricultural, socio-economic and environmental impact of these fungi, most aspects of their life cycles are unknown, and the phylogenetic relationships of M. roreri have yet to be conclusively established. In this paper, extensive phylogenetic analyses of five nuclear gene regions (28S rDNA, 18S rDNA, ITS, RPB1, and EF1-alpha) confirm that C. perniciosa and M. roreri are sister taxa that belong in the Marasmiaceae (euagarics). Furthermore, these taxa form part of a separate and distinct lineage within the family. This lineage includes the biotrophic fungi Moniliophthora perniciosa comb. nov. and M. roreri, as well as one undescribed endophytic species. The sister genera to Moniliophthora are Marasmius, Crinipellis and Chaetocalathus, which consist mainly of saprotrophic litter fungi.

« Effets-tableaux » et parergon dans Macbeth Meeting the Three Witches par Francesco Zuccarelli et par Henry Füssli d’après Macbeth Pictorialism and “ergon” in the paintings of Macbeth Meeting the Three Witches by Francesco Zuccarelli (1760 and Henry Fuseli (1793-1794 after Macbeth

Directory of Open Access Journals (Sweden)

Nathalie Padilla

2006-01-01

Full Text Available During the 18th century, Shakespeare’s Macbeth was a source of inspiration for many painters who tried to underscore the pictorial quality of the play, especially that of Act 1, scene 3. The paper compares the interpretations offered by Henry Fuseli and Francesco Zuccarelli who were both foreign artists belonging to the Royal Academy of London. Their paintings after Act 1, scene 3, of Macbeth offer a visual representation articulated around contrast and convergence: if Fuseli remains faithful to the pivotal emotional intent, seen as the “ergon” here, Zuccarelli almost ignores it, finding a greater interest in the landscape of the scene that fills most of his pictorial space. However, the two works fuse together within the etymology of the term “ergon”, that equates with “work” or “action”. They illustrate the idea of active witchcraft through natural phenomena controlled by the three witches.

Energy behaviour of neutrons generated by Witch-type distributed axi-symmetrical deuteron beams accelerated onto plane tritium targets

International Nuclear Information System (INIS)

Timus, D.M.; Bradley, D.A.; Timus, B.D.; Kalla, S.L.; Srivastava, H.M.

2000-01-01

This paper is an analytical study of the spatial dependency of the d-T neutron energy in the vicinity of a homogeneous tritium-occluded plane target. Close to the target, and along the path of incidence of axially symmetric deuteron beams, the transverse density of accelerated deuterons is assumed to be governed by a law approximated by the 'Witch' function. In particular circumstances, the elementary neutron emission process in non-dispersive media can be considered to be omni-directional (due consideration being paid to collision kinetics, depending upon mass and kinetic energy of particles involved in the nuclear collision, nuclear reaction energy, etc.). Consequently, analytical expressions can be considerably simplified. By applying the classical kinetic energy and momentum conservation laws to nuclear processes, a theoretical description is obtained, taking into account the exoergic character of d-T fusion reaction. A number of expressions for energetic prediction of the fast neutron field are proposed. The associated relations, involving elementary functions, can be investigated using a desk-top computer. Computationally tractable tools are of importance in the study of diverse situations such as induced reactions and activation analysis using 14 MeV neutron generators, investigations in health-physics, radiation dose measurements, nuclear medicine, damage effects, and simulation studies

"Getting tested is almost like going to the Salem witch trials": discordant discourses between Western public health messages and sociocultural expectations surrounding HIV testing among East African immigrant women.

Science.gov (United States)

De Jesus, Maria; Carrete, Claudia; Maine, Cathleen; Nalls, Patricia

2015-01-01

Washington, DC, has the highest AIDS diagnosis rate in the USA, and Black women are disproportionately affected. Although HIV testing is the first entryway into vital treatment services, evidence reveals that foreign-born blacks have a lower rate of recent HIV testing than US-born blacks. To date, however, there are no studies that examine the culture-specific perceptions of HIV testing among East African immigrant women (who comprise a large share of Black Africans in DC) to better understand their potential barriers to testing. Adopting the PEN-3 cultural model as our theoretical framework, the main objective of this study was to examine East African women's HIV testing perceptions and partner communication norms. Between October 2012 and March 2013, trained interviewers conducted a total of 25 interviews with East African women in the Washington, DC, metropolitan area. For triangulation purposes, data collection consisted of both in-depth, semi-structured interviews and cognitive interviews, in which participants were administered a quantitative survey and assessed on how they interpreted items. Qualitative thematic analysis revealed a systematic pattern of discordant responses across participants. While they were aware of messages related to Western public health discourse surrounding HIV testing (e.g., Everyone should get tested for HIV; One should talk to one's spouse about HIV testing), divergent sociocultural expectations rooted in cultural and religious beliefs prevailed (e.g., Getting an HIV test brings shame to the person who got tested and to one's family; it implies one is engaging in immoral behavior; One should not talk with one's spouse about HIV testing; doing so breaks cultural norms). Implications of using a culture-centered model to examine the role of sociocultural expectations in HIV prevention research and to develop culturally responsive prevention strategies are discussed.

Monitoring equipment environment during nuclear plant operation at Salem and Hope Creek generating stations

International Nuclear Information System (INIS)

Blum, A.; Smith, R.J.

1991-01-01

Monitoring of environmental parameters has become a significant issue for operating nuclear power plants. While the long-term benefits of plant life extension programs are being pursued with comprehensive environmental monitoring programs, the potential effect of local hot spots at various plant locations needs to be evaluated for its effect on equipment degradation and shortening of equipment qualified life. A significant benefit can be experienced from temperature monitoring when a margin exists between the design versus actual operating temperature. This margin can be translated into longer equipment qualified life and significant reduction in maintenance activities. At PSE and G, the immediate need for monitoring environmental parameters is being accomplished via the use of a Logic Beach Bitlogger. The Bitlogger is a portable data loggings system consisting of a system base, input modules and a communication software package. Thermocouples are installed on selected electrical equipment and cables are run from the thermocouples to the input module of the Bitlogger. Temperature readings are taken at selected intervals, stored in memory, and downloaded periodically to a PC software program, i.e., Lotus. The data is formatted into tabular or graphical documents. Because of their versatility, Bitloggers are being used differently at the authors Nuclear facility. At the Salem Station (2 Units-4 loop Westinghouse PWR), a battery powered, fully portable, calibrated Bitlogger is located in an accessible area inside Containment where it monitors the temperature of various electrical equipment within the Pressurizer Enclosure. It is planned that close monitoring of the local hot spot temperatures in this area will allow them to adjust and reconcile the environmental qualification of the equipment

Witchcraft

NARCIS (Netherlands)

Geschiere, P.; Wright, J.D.

2015-01-01

Till far into the twentieth century two nodal points in the study of witchcraft stood out: the work by historians on witch trials in early modern Europe, and anthropologists' studies of its role in local tensions in Africa and Melanesia. The differences between the two settings were so glaring that

Population genetic analysis reveals a low level of genetic diversity of 'Candidatus Phytoplasma aurantifolia' causing witches' broom disease in lime.

Science.gov (United States)

Al-Abadi, Shaikha Y; Al-Sadi, Abdullah M; Dickinson, Matthew; Al-Hammadi, Mohammed S; Al-Shariqi, Rashid; Al-Yahyai, Rashid A; Kazerooni, Elham A; Bertaccini, Assunta

2016-01-01

Witches' broom disease of lime (WBDL) is a serious phytoplasma disease of acid lime in Oman, the UAE and Iran. Despite efforts to study it, no systemic study attempted to characterize the relationship among the associated phytoplasma, ' Candidatus Phytoplasma aurantifolia', from the three countries. This study utilized sequences of the 16S rRNA, imp and secA genes to characterize 57 strains collected from Oman (38), the UAE (9) and Iran (10). Phylogenetic analysis based on the 16S rRNA gene showed that the 57 strains shared 98.5-100 % nucleotide similarity to each other and to strains of ' Ca . P. aurantifolia' available in GenBank. The level of genetic diversity was low based on the 16S rRNA (0-0.011), imp (0-0.002) and secA genes (0-0.015). The presence of low level of diversity among phytoplasma strains from Oman, the UAE and Iran can be explained by the movement of infected lime seedlings from one country to another through trading and exchange of infected plants. The study discusses implication of the findings on WBDL spread and management.

Functional and biophysical studies on four ceratoplatanins from the fungus Moniliophthora perniciosa, causal agent of the Witche's broom disease

International Nuclear Information System (INIS)

Barsottini, M.; Zaparoli, G.; Garcia, O.; Pereira, G.A.G.; Oliveira, J.F.; Tiezzi, H.O.; Ambrosio, A.L.B.; Dias, S.M.G.

2012-01-01

Full text: Ceratoplatanin (CP) is a secreted protein of 12.4 kDa initially identified in culture filtrates of the disease ascomycete Ceratocystis fimbriata f. sp. platani, etiological agent of the canker stain disease. CP is also the founding member of the namesake protein family, which contains fungal-secreted proteins involved in various stages of the host-fungus interaction and may act as phytotoxins or elicitors of defense response. Besides the low molecular weight, CPs have a high percentage of hydrophobic residues and share two conserved intramolecular disulfide bonds. It has been suggested that CPs have important physiological functions, including interaction with cell wall or cell membrane and manipulation of the host's defense system. Furthermore, a recent work showed that the ceratoplatanin from C. fimbriata has some degree of affinity for the saccharide 4-N-acetylglucosamine. However, its precise molecular function remains elusive. Five putative CPs have been identified in Moniliophthora perniciosa a basidiomycete fungus responsible for great economic losses in cocoa industry in the form of Witches' broom disease (WBD) , four of which had their crystal structures resolved by our group. In this work we report biophysical and functional studies on these MpCPs aiming at understanding their role and importance during the WBD progression. (author)

Geospatial tool-based morphometric analysis using SRTM data in Sarabanga Watershed, Cauvery River, Salem district, Tamil Nadu, India

Science.gov (United States)

Arulbalaji, P.; Gurugnanam, B.

2017-11-01

A morphometric analysis of Sarabanga watershed in Salem district has been chosen for the present study. Geospatial tools, such as remote sensing and GIS, are utilized for the extraction of river basin and its drainage networks. The Shuttle Radar Topographic Mission (SRTM-30 m resolution) data have been used for morphometric analysis and evaluating various morphometric parameters. The morphometric parameters of Sarabanga watershed have been analyzed and evaluated by pioneer methods, such as Horton and Strahler. The dendritic type of drainage pattern is draining the Sarabanga watershed, which indicates that lithology and gentle slope category is controlling the study area. The Sarabanga watershed is covered an area of 1208 km2. The slope of the watershed is various from 10 to 40% and which is controlled by lithology of the watershed. The bifurcation ratio ranges from 3 to 4.66 indicating the influence of geological structure and suffered more structural disturbances. The form factor indicates elongated shape of the study area. The total stream length and area of watershed indicate that mean annual rainfall runoff is relatively moderate. The basin relief expressed that watershed has relatively high denudation rates. The drainage density of the watershed is low indicating that infiltration is more dominant. The ruggedness number shows the peak discharges that are likely to be relatively higher. The present study is very useful to plan the watershed management.

A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao.

Science.gov (United States)

Mondego, Jorge M C; Carazzolle, Marcelo F; Costa, Gustavo G L; Formighieri, Eduardo F; Parizzi, Lucas P; Rincones, Johana; Cotomacci, Carolina; Carraro, Dirce M; Cunha, Anderson F; Carrer, Helaine; Vidal, Ramon O; Estrela, Raíssa C; García, Odalys; Thomazella, Daniela P T; de Oliveira, Bruno V; Pires, Acássia Bl; Rio, Maria Carolina S; Araújo, Marcos Renato R; de Moraes, Marcos H; Castro, Luis A B; Gramacho, Karina P; Gonçalves, Marilda S; Neto, José P Moura; Neto, Aristóteles Góes; Barbosa, Luciana V; Guiltinan, Mark J; Bailey, Bryan A; Meinhardt, Lyndel W; Cascardo, Julio Cm; Pereira, Gonçalo A G

2008-11-18

The basidiomycete fungus Moniliophthora perniciosa is the causal agent of Witches' Broom Disease (WBD) in cacao (Theobroma cacao). It is a hemibiotrophic pathogen that colonizes the apoplast of cacao's meristematic tissues as a biotrophic pathogen, switching to a saprotrophic lifestyle during later stages of infection. M. perniciosa, together with the related species M. roreri, are pathogens of aerial parts of the plant, an uncommon characteristic in the order Agaricales. A genome survey (1.9x coverage) of M. perniciosa was analyzed to evaluate the overall gene content of this phytopathogen. Genes encoding proteins involved in retrotransposition, reactive oxygen species (ROS) resistance, drug efflux transport and cell wall degradation were identified. The great number of genes encoding cytochrome P450 monooxygenases (1.15% of gene models) indicates that M. perniciosa has a great potential for detoxification, production of toxins and hormones; which may confer a high adaptive ability to the fungus. We have also discovered new genes encoding putative secreted polypeptides rich in cysteine, as well as genes related to methylotrophy and plant hormone biosynthesis (gibberellin and auxin). Analysis of gene families indicated that M. perniciosa have similar amounts of carboxylesterases and repertoires of plant cell wall degrading enzymes as other hemibiotrophic fungi. In addition, an approach for normalization of gene family data using incomplete genome data was developed and applied in M. perniciosa genome survey. This genome survey gives an overview of the M. perniciosa genome, and reveals that a significant portion is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle. Our analysis provides new evidence revealing potential adaptive traits that may play major roles in the mechanisms of pathogenicity in the M. perniciosa/cacao pathosystem.

A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao

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Bailey Bryan A

2008-11-01

Full Text Available Abstract Background The basidiomycete fungus Moniliophthora perniciosa is the causal agent of Witches' Broom Disease (WBD in cacao (Theobroma cacao. It is a hemibiotrophic pathogen that colonizes the apoplast of cacao's meristematic tissues as a biotrophic pathogen, switching to a saprotrophic lifestyle during later stages of infection. M. perniciosa, together with the related species M. roreri, are pathogens of aerial parts of the plant, an uncommon characteristic in the order Agaricales. A genome survey (1.9× coverage of M. perniciosa was analyzed to evaluate the overall gene content of this phytopathogen. Results Genes encoding proteins involved in retrotransposition, reactive oxygen species (ROS resistance, drug efflux transport and cell wall degradation were identified. The great number of genes encoding cytochrome P450 monooxygenases (1.15% of gene models indicates that M. perniciosa has a great potential for detoxification, production of toxins and hormones; which may confer a high adaptive ability to the fungus. We have also discovered new genes encoding putative secreted polypeptides rich in cysteine, as well as genes related to methylotrophy and plant hormone biosynthesis (gibberellin and auxin. Analysis of gene families indicated that M. perniciosa have similar amounts of carboxylesterases and repertoires of plant cell wall degrading enzymes as other hemibiotrophic fungi. In addition, an approach for normalization of gene family data using incomplete genome data was developed and applied in M. perniciosa genome survey. Conclusion This genome survey gives an overview of the M. perniciosa genome, and reveals that a significant portion is involved in stress adaptation and plant necrosis, two necessary characteristics for a hemibiotrophic fungus to fulfill its infection cycle. Our analysis provides new evidence revealing potential adaptive traits that may play major roles in the mechanisms of pathogenicity in the M. perniciosa

Proteomic analysis during of spore germination of Moniliophthora perniciosa, the causal agent of witches' broom disease in cacao.

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Mares, Joise Hander; Gramacho, Karina Peres; Santos, Everton Cruz; da Silva Santiago, André; Santana, Juliano Oliveira; de Sousa, Aurizângela Oliveira; Alvim, Fátima Cerqueira; Pirovani, Carlos Priminho

2017-08-17

Moniliophthora perniciosa is a phytopathogenic fungus responsible for witches' broom disease of cacao trees (Theobroma cacao L.). Understanding the molecular events during germination of the pathogen may enable the development of strategies for disease control in these economically important plants. In this study, we determined a comparative proteomic profile of M. perniciosa basidiospores during germination by two-dimensional SDS-PAGE and mass spectrometry. A total of 316 proteins were identified. Molecular changes during the development of the germinative tube were identified by a hierarchical clustering analysis based on the differential accumulation of proteins. Proteins associated with fungal filamentation, such as septin and kinesin, were detected only 4 h after germination (hag). A transcription factor related to biosynthesis of the secondary metabolite fumagillin, which can form hybrids with polyketides, was induced 2 hag, and polyketide synthase was observed 4 hag. The accumulation of ATP synthase, binding immunoglobulin protein (BiP), and catalase was validated by western blotting. In this study, we showed variations in protein expression during the early germination stages of fungus M. perniciosa. Proteins associated with fungal filamentation, and consequently with virulence, were detected in basidiospores 4 hag., for example, septin and kinesin. We discuss these results and propose a model of the germination of fungus M. perniciosa. This research can help elucidate the mechanisms underlying basic processes of host invasion and to develop strategies for control of the disease.

Characterization of a protease produced by a Trichoderma harzianum isolate which controls cocoa plant witches' broom disease

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Felix Carlos

2002-01-01

Full Text Available Abstract Background Several Trichoderma strains have been reported to be effective in controlling plant diseases, and the action of fungal hydrolytic enzymes has been considered as the main mechanism involved in the antagonistic process. However, although Trichoderma strains were found to impair development of Crinipellis perniciosa, the causal agent of cocoa plant witches' broom disease, no fungal strain is available for effective control of this disease. We have then undertaken a program of construction of hydrolytic enzyme-overproducing Trichoderma strains aiming improvement of the fungal antagonistic capacity. The protease of an indian Trichoderma isolate showing antagonistic activity against C. perniciosa was purified to homogeneity and characterized for its kinetic properties and action on the phytopathogen cell wall. Results A protease produced by the Trichoderma harzianum isolate 1051 was purified to homogeneity by precipitation with ammonium sulfate followed by hydrophobic chromatography. The molecular mass of this protease as determined by SDS-polyacrylamide gel electrophoresis was about 18.8 kDa. Its N-terminal amino acid sequence shares no homology with any other protease. The purified enzyme substantially affected the cell wall of the phytopathogen C. perniciosa. Western-blotting analysis showed that the enzyme was present in the culture supernatant 24 h after the Trichoderma started to grow in casein-containing liquid medium. Conclusions The capacity of the Trichoderma harzianum protease to hydrolyze the cell wall of C. perniciosa indicates that this enzyme may be actually involved in the antagonistic process between the two fungi. This fact strongly suggest that hydrolytic enzyme over-producing transgenic fungi may show superior biocontrol capacity.

Bruxas e índias filhas de Saturno: arte, bruxaria e canibalismo Witches and indian women, daughters of Saturn: arts, witchcraft and cannibalism

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Yobenj Aucardo Chicangana-Bayona

2009-08-01

Full Text Available O artigo indaga pela representação da mulher nas pinturas e gravuras sobre a bruxaria dos séculos XVI e XVII, procurando estabelecer uma tipologia iconográfica e percorrendo a construção de estigmas negativos imputados no corpo feminino e na sua degradação natural. O texto, apoiado em fontes visuais como pinturas e gravuras, principalmente da Renascença alemã, demonstra como as índias do Novo Mundo foram associadas com as bruxas da Europa e com o deus clássico Saturno, através do mito do canibalismo.The article inquires into the representation of women in the paintings and engravings about witchcraft in the XVI-XVII centuries, trying to establish an iconographic typology and covering the construction of negative stigmas attributed to the feminine body and its natural degradation. Through the support of visual sources such as paintings and engravings, mainly from the German Renaissance, the text demonstrates how the Indian women of the New World were associated to the witches of Europe and with the classic god Saturn, through the myth of cannibalism.

Functional and biophysical studies on four ceratoplatanins from the fungus Moniliophthora perniciosa, causal agent of the Witche's broom disease

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Barsottini, M.; Zaparoli, G.; Garcia, O.; Pereira, G.A.G. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil); Oliveira, J.F.; Tiezzi, H.O.; Ambrosio, A.L.B.; Dias, S.M.G. [Laboratorio Nacional de Biociencias - LNBIO, Campinas, SP (Brazil)

2012-07-01

Full text: Ceratoplatanin (CP) is a secreted protein of 12.4 kDa initially identified in culture filtrates of the disease ascomycete Ceratocystis fimbriata f. sp. platani, etiological agent of the canker stain disease. CP is also the founding member of the namesake protein family, which contains fungal-secreted proteins involved in various stages of the host-fungus interaction and may act as phytotoxins or elicitors of defense response. Besides the low molecular weight, CPs have a high percentage of hydrophobic residues and share two conserved intramolecular disulfide bonds. It has been suggested that CPs have important physiological functions, including interaction with cell wall or cell membrane and manipulation of the host's defense system. Furthermore, a recent work showed that the ceratoplatanin from C. fimbriata has some degree of affinity for the saccharide 4-N-acetylglucosamine. However, its precise molecular function remains elusive. Five putative CPs have been identified in Moniliophthora perniciosa a basidiomycete fungus responsible for great economic losses in cocoa industry in the form of Witches' broom disease (WBD) , four of which had their crystal structures resolved by our group. In this work we report biophysical and functional studies on these MpCPs aiming at understanding their role and importance during the WBD progression. (author)

Airborne gamma-ray spectrometer and magnetometer survey: Crescent Quadrangle, Burns Quadrangle, Canyon City Quadrangle, Bend Quadrangle, Salem Quadrangle (Oregon). Final report

International Nuclear Information System (INIS)

1981-01-01

An airborne combining radiometric and magnetic survey was performed for the Department of Energy over the area covered by the Burns, Crescent, Canyon City, Bend, and Salem, Washington 1:250,000 National Topographic Map Series, 1 0 x 2 0 quadrangle maps. The survey was a part of DOE's National Aerial Radiometric Reconnaissance program, which is in turn a part of the National Uranium Resource Evaluation program. Data were collected by a helicopter equipped with a gamma-ray spectrometer having a large crystal volume, and a high sensitivity proton precession magnetometer. The radiometric system was calibrated at the Walker Field Calibration pads and the Lake Mead Dynamic Test range. Data quality was ensured throughout the survey by daily test flights and equipment checks. Radiometric data were corrected for live time, aircraft and equipment background, cosmic background, atmospheric radon, Compton scatter, and altitude dependence. The corrected data were statistically evaluated, plotted, and contoured to produce anomaly maps based on the radiometric response of individual geological units. These maps were interpreted and an anomaly interpretation map produced. Volume I contains a description of the systems used in the survey, a discussion of the calibration of the systems, the data processing procedures, the data display format, the interpretation rationale, and the interpretation methodology. A separate Volume II for each quadrangle contains the data displays and the interpretation results

Symbolism in Harold Pinter's The Caretaker,and Taha Salem's Madina That Al-Jather Al-Takibi A Comparative Study

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Nadia Ali Akbar

2017-03-01

Full Text Available The twentieth century represents a new shift in the understanding of the circumstances which effect the state of man. New moralities, new values and new estimations were created. Two World Wars brought not only hardships and damages, but also an enlargement in the scope and perception of artists. It is worth nothing that symbolism forms an indispensable part in the theatre of the Absurd. Harold Pinter was an English playwright, screenwriter, actor, director, political, activist, and poet. He was among the most influential British playwrights of modern times, and in 2005 he was awarded the Noble Prize for literature. Pinter's plays must be read many times in order to realize the extent of the symbolism that he uses. In The Caretaker 1959; it is a three act play, he uses the symbols to reflect that the modern world is in a state of absurdity and mess, and man as a part of his world becomes a real reflection of this absurdity and mess in all its kinds. Modern man loses his belief and certainty in such things as love, charity, and understanding as Pinter argues that every man encounters violence in some way or other. All this is clearly represented by the three characters in The Caretaker especially Davies. Taha Salem is another Iraqi playwright who was utilized or assimilated different event grade techniques to convey certain social aims. Madina Taht Al-Jather Al-Takibi. (A City Under A Cubic Root is a play with some awareness of the Absurd drama. This awareness is mainly materialized in the overuse of symbolism which is one of the basic aspects of the theatre of the Absurd.

Knowledge on practice of weaning among the mothers with infant below six months of age in Salem, Tamilnadu

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N Dhanasekaran

2015-09-01

Full Text Available Background & Objectives: Weaning is essential to child nutrition, which reduce infant mortality rate and related malnutrition with healthy feeding practice. Hence the mothers are expected to be knowledgeable on weaning.Objectives: To assess the knowledge on practice of weaning, to compare the knowledge on practice and to find out association between the knowledge scores of mothers with infant below 6 months with selected demographic variables.Materials and Methods: A descriptive design with cross sectional survey approach was undertaken to assess the knowledge on practice of weaning mothers with infant below 6 months of age in selected hospital, Salem, Tamil Nadu. Fifty mothers were selected by purposive sampling technique and data was collected by using structured interview schedule from 06/11/14 to 20/11/14.Results: Demographic characteristics reveal that highest percentage (84 % of them belongs to the Hindu religion and had one child below the 6 months of the age. Comparisons of the knowledge score with demography highest mean and SD in relation to family income Rs 4001 - 6000 shows that (14.7 ± 1.16. The Overall Mean knowledge score was (11.5 ± 3.26and (50 % revealing average knowledge. However there was significant association between knowledge score and education & type of family (P = 0.0151 & P = 0.0091 revealing that maximum demographic variables do not affected the level of knowledge.Conclusion: The overall knowledge is average. However lowest percentage in the areas of “principles of feeding and storage” and “age of introducing on weaning” were attention seeking, implying the necessity to improve the knowledge in regard to prevent malnutrition.JCMS Nepal. 2015;11(1: 12-16

Witchcraft, genealogy, Foucault.

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Russell, S

2001-03-01

This paper is a genealogical reflection on both the historiography of European witchcraft and the dynamics of witchcraft trials. I argue that traditional scholarly assumptions about the 'unsophisticated' nature of early modern European mentalities result in inadequate representations of accused witches and of the social contexts and processes of the trials. Genealogy, by contrast, problematizes fundamental notions such as reason, order, power and progress in ways that not only provide a different range of effective tools for the analysis of belief in witchcraft, but also underline its crucial significance for social theory. In the final section, an analysis of a typical trial is undertaken employing key genealogical insights into confession, torture, truth, governmentality, power, pleasure and pain.

Zircon U-Pb age, Lu-Hf isotope, mineral chemistry and geochemistry of Sundamalai peralkaline pluton from the Salem Block, southern India: Implications for Cryogenian adakite-like magmatism in an aborted-rift

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Renjith, M. L.; Santosh, M.; Li, Tang; Satyanarayanan, M.; Korakoppa, M. M.; Tsunogae, T.; Subba Rao, D. V.; Kesav Krishna, A.; Nirmal Charan, S.

2016-01-01

The Sundamalai peralkaline pluton is one among the Cryogenian alkaline plutons occurring in the Dharmapuri Rift Zone (DRZ) of the Salem Block in the Southern Granulite Terrane (SGT) of India. Here we present zircon U-Pb age and Lu-Hf isotopic composition, mineral chemistry and geochemistry of the pluton to explore the petrogenesis and geodynamic implications. Systematic modal variation of orthoclase, Na-plagioclase, Ca-amphibole (ferro-edenite and hastingsite) and quartz developed quartz-monzonite and granite litho units in the Sundamalai pluton. Thermometry based on amphibole-plagioclase pair suggests that the pluton was emplaced and solidified at around 4.6 kbar pressure with crystallization of the major phases between 748 and 661 °C. Estimated saturation temperature of zircon (712-698 °C) is also well within this range. However, apatite saturation occurred at higher temperatures between 835 and 870 °C, in contrast with monazite saturation (718-613 °C) that continued up to the late stage of crystallization. Estimated oxygen fugacity values (log fO2: -14 to -17) indicate high oxidation state for the magma that stabilized titanite and magnetite. The magmatic zircons from Sundamalai pluton yielded a weighted mean 206Pb/238U age of 832.6 ± 3.2 Ma. Geochemically, the Sundamalai rocks are high-K to shoshonitic, persodic (Na2O/K2O ratio > 1), silica-saturated (SiO2:65-72 wt.%), and peralkaline in composition (aluminum saturation index, ASI Sc(2-3 ppm), positive Sr anomaly and predominantly negative zircon εHf(t) values (-10.8 to -9.3 with an average of -10.2) and initial 176Hf/177Hf ratios (0.281947-0.282022) confirm a Paleoproterozoic crustal source. Based on the field and geochemical evidences, we propose that a previously metasomatized mafic lower-crustal source enriched in alkalis has undergone CO2-present partial melting as a result of asthenospheric upwelling beneath an aborted rifting along the DRZ generating the magma that crystallized the Sundamalai rocks

[Medical practice, magic and religion - conjunction and development before and after Reformation].

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Thorvardardottir, Olina Kjerulf

2017-12-01

The conjunction between medical practice, religion and magic becomes rather visible when one peers into old scripts and ancient literature. Before the foundation and diffusion of universities of the continent, the european convents and cloisters were the centers of medical knowl-edge and -practice for centuries. Alongside the scholarly development of medical science, driven from the roots of the eldest scholarly medicial practice, the practice of folk-medicin flourished and thrived all over Europe, not least the herbal-medicine which is the original form and foundation for modern pharmacy. This article deals with the conjunction of religion, magic and medical practice in ancient Icelandic sources such as the Old-Norse literature, medical-scripts from the 12th - 15th century Iceland, and not least the Icelandic magical-scripts (galdrakver) of the 17th century. The last mentioned documents were used as evidence in several witch-trials that led convicted witches to suffer executions at the stake once the wave of European witch-persecutions had rushed ashore in 17th century Iceland. These sources indicate a decline of medical knowledge and science in the 16th and 17th century Iceland, the medical practice being rather undeveloped at the time - in Iceland as in other parts of Europe - there-fore a rather unclear margin between "the learned and the laymen". While common people and folk-healers were convicted as witches to suffer at the stake for possession of magical scripts and healing-books, some scholars of the state of Danmark were practicing healing-methods that deserve to be compared to the activities of the former ones. That comparison raises an inevitable question of where to draw the line between the learned medical man and the magician of 17th century Iceland, that is between Magic and Science.

Cacao breeding in Bahia, Brazil - strategies and results

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Uilson Vanderlei Lopes

2011-01-01

Full Text Available Cacao was introduced in Bahia in 1756, becoming later the largest producer state in the country. In order to supportthe planting of cacao in the region, a breeding program was established by CEPEC at the beginning of the 1970s. For a long time,the program consisted in testing new hybrids (full-sibs and releasing a mixture of the best ones to farmers. Lately, particularly afterthe witches´ broom arrival in the region, in 1989, recurrent breeding strategies were implemented, aiming mainly the developmentof clones. From 1993 to 2010, more than 500 progenies, accumulating 30 thousand trees, were developed by crossing many parentswith resistance to witches´ broom, high yield and other traits. In this period, more than 500 clones were put in trials and 39 clonesand 3 hybrids were released to farmers. In this paper the strategies and results achieved by the program are reviewed. Overall theprogram has good interface with pathology and genomic programs.

Parallel Worlds

DEFF Research Database (Denmark)

Steno, Anne Mia

2013-01-01

The purpose of the present article is to make a contribution to an understanding of what it means to be a witch in Denmark today. The article thus reviews the extent of magical circles in Denmark and highlights special characteristics of the modern witch. The magical practice of witches is elucid...

PREVALENCE OF PAEDIATRIC DERMATOSES IN THE AGE GROUP OF 5-14 YEARS AT A TERTIARY CARE CENTER IN SALEM

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Prasanna Kanniah Baskara

2017-01-01

Full Text Available BACKGROUND Skin diseases in pediatric age group are common all over the world. Pediatric dermatoses require separate view from adult dermatoses as there are differences in their clinical presentation and treatment. OBJECTIVE The aim of our study was to determine the prevalence of pediatric dermatoses attending our tertiary care center. MATERIALS AND METHODS This was a cross-sectional study conducted in 100 consecutive children with dermatoses between 5-14 years of age attending dermatology outpatient department at Vinayaka Missions Kirupananda Variyar medical college, Salem. The study was conducted over a period of 6 months from February 2016 to August 2016. Demographic parameters, detailed history, clinical features and diagnosis were recorded and analyzed. RESULTS In our short term study, we examined 100 pediatric cases with 106 dermatoses. The incidence of infections and infestations (43.39% was more prevalent in our study. The most common non-infectious dermatoses in our study was insect bite reactions (17.9%. Dermatitis and eczema (9.39%, disorders of sweat and sebaceous glands (6.6%, pigmentary disorders (5.66%, disorders of hair and nails (3.77%, genetic disorders (2.88%, immune and allergic disorders (2.8%, psoriasis (2.8%, nutritional disorders (0.9%, Polymorphic light eruption (0.9%, pearly penile papule (0.9%, aphthous ulcer (0.9% and pityriasis rosea (0.9% were the other dermatoses seen in the study.CONCLUSION Fungal infections (tinea versicolor and tinea corporis, scabies and insect bite reactions were the common dermatoses observed in our study. Most of the pediatric patients attending our hospital came from rural areas belonging to low socioeconomic strata. Health education, proper sanitation and improved nutrition will help to reduce the incidence of pediatric dermatoses.

78 FR 35874 - Procurement List; Proposed Additions

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2013-06-14

... proposed for addition to the Procurement List for production by the nonprofit agencies listed: Products... Cleaner NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC Contracting Activity: Defense...

75 FR 57444 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe from the People's...

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2010-09-21

..., Toyota Tsusho American Inc. (``TAI''), and Salem Steel North America, LLC (``Salem Steel'') on August 26... material injury, or threat of material injury, does not exist, this proceeding will be terminated and all...

Emergency Assessment of Debris-Flow Hazards from Basins Burned by the 2007 Witch Fire, San Diego County, Southern California

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Cannon, Susan H.; Gartner, Joseph E.; Michael, John A.; Bauer, Mark A.; Stitt, Susan C.; Knifong, Donna L.; McNamara, Bernard J.; Roque, Yvonne M.

2007-01-01

INTRODUCTION The objective of this report is to present a preliminary emergency assessment of the potential for debris-flow generation from basins burned by the Witch Fire in San Diego County, southern California in 2007. Debris flows are among the most hazardous geologic phenomena; debris flows that followed wildfires in southern California in 2003 killed 16 people and caused tens of millions of dollars of property damage. A short period of even moderate rainfall on a burned watershed can lead to debris flows. Rainfall that is normally absorbed into hillslope soils can run off almost instantly after vegetation has been removed by wildfire. This causes much greater and more rapid runoff than is normal from creeks and drainage areas. Highly erodible soils in a burn scar allow flood waters to entrain large amounts of ash, mud, boulders, and unburned vegetation. Within the burned area and downstream, the force of rushing water, soil, and rock can destroy culverts, bridges, roadways, and buildings, potentially causing injury or death. This emergency debris-flow hazard assessment is presented as relative ranking of the predicted median volume of debris flows that can issue from basin outlets in response to 2.25 inches (57.15 mm) of rainfall over a 3-hour period. Such a storm has a 10-year return period. The calculation of debris flow volume is based on a multiple-regression statistical model that describes the median volume of material that can be expected from a recently burned basin as a function of the area burned at high and moderate severity, the basin area with slopes greater than or equal to 30 percent, and triggering storm rainfall. Cannon and others (2007) describe the methods used to generate the hazard maps. Identification of potential debris-flow hazards from burned drainage basins is necessary to issue warnings for specific basins, to make effective mitigation decisions, and to help plan evacuation timing and routes.

Medline Plus

Full Text Available ... Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 7/ ... 2014) Percutaneous Placement of a Pulmonary Valve (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 12/ ...

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Full Text Available ... Minimally Invasive, Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, ... Minimally Invasive, Nonsurgical Approach to Repairing Mitral Valve Leaks (Wake Forest University Baptist Medical Center, Winston-Salem, ...

76 FR 9555 - Procurement List; Additions and Deletions

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2011-02-18

...-8067--Inkjet printer cartridge. NPA: Alabama Industries for the Blind, Talladega, AL. Contracting... Services Administration, New York, NY. Service Service Type/Location: Eyewear Prescription Service...: Winston-Salem Industries for the Blind, Inc., Winston- Salem, NC. Contracting Activity: Department of...

Battling demons with medical authority: werewolves, physicians and rationalization.

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Metzger, Nadine

2013-09-01

Werewolves and physicians experienced their closest contact in the context of early modern witch and werewolf trials. For medical critics of the trials, melancholic diseases served as reference points for medical explanations of both individual cases and werewolf beliefs in general. This paper attempts to construct a conceptual history of werewolf beliefs and their respective medical responses. After differentiating the relevant terms, pre-modern werewolf concepts and medical lycanthropy are introduced. The early modern controversy between medical and demonological explanations forms the main part of this study. The history of werewolves and their medical explanations is then traced through to present times. An important point of discussion is to what extent the physicians' engagements with werewolves can be characterized as rationalization.

Parallelle verdener

DEFF Research Database (Denmark)

Steno, Anne Mia

2012-01-01

The purpose of the present article is to make a contribution to an understanding of what it means to be a witch in Denmark today. The article thus reviews the extent of the magical circle in Denmark and highlights special characteristics of the modern witch. The magical practice of the witches is...... that the motivations and the subtle shades of the magical practice are overlooked if the analysis does not include the above questions and approach, and it underlines the importance of physicality in the magical practice....... of something else, for instance as a way of handling uncertainty in difficult times, magical practice should be seen as an emic concept, and the way in which the witches exist in and understand this world. In this context, the understanding of the existence of two parallel universes is important: the profane...

To Converse with the Devil? Speech, Sexuality, and Witchcraft in Early Modern Scotland

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Sierra Rose Dye

2012-10-01

Full Text Available In early modern Scotland, thousands of people were accused and tried for the crime of witchcraft, many of whom were women. This paper examines the particular qualities associated with witches in Scottish belief – specifically speech and sexuality – in order to better understand how and why the witch hunts occurred. This research suggests that the growing emphasis on the words of witches during this period was a reflection of a mounting concern over the power and control of speech in early modern society. In looking at witchcraft as a speech crime, it is possible to explain not only why accused witches were more frequently women, but also how the persecution of individuals – both male and female – functioned to ensure that local and state authorities maintained a monopoly on powerful speech.

Mapping of groundwater potential zones in Salem Chalk Hills, Tamil Nadu, India, using remote sensing and GIS techniques.

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Thilagavathi, N; Subramani, T; Suresh, M; Karunanidhi, D

2015-04-01

This study proposes to introduce the remote sensing and geographic information system (GIS) techniques in mapping the groundwater potential zones. Remote sensing and GIS techniques have been used to map the groundwater potential zones in Salem Chalk Hills, Tamil Nadu, India. Charnockites and fissile hornblende biotite gneiss are the major rock types in this region. Dunites and peridodites are the ultramafic rocks which cut across the foliation planes of the gneisses and are highly weathered. It comprises magnesite and chromite deposits which are excavated by five mining companies by adopting bench mining. The thickness of weathered and fracture zone varies from 2.2 to 50 m in gneissic formation and 5.8 to 55 m in charnockite. At the contacts of gneiss and charnockite, the thickness ranges from 9.0 to 90.8 m favoring good groundwater potential. The mine lease area is underlined by fractured and sheared hornblende biotite gneiss where groundwater potential is good. Water catchment tanks in this area of 5 km radius are small to moderate in size and are only seasonal. They remain dry during summer seasons. As perennial water resources are remote, the domestic and agricultural activities in this region depend mainly upon the groundwater resources. The mines are located in gently slope area, and accumulation of water is not observed except in mine pits even during the monsoon period. Therefore, it is essential to map the groundwater potential zones for proper management of the aquifer system. Satellite imageries were also used to extract lineaments, hydrogeomorphic landforms, drainage patterns, and land use, which are the major controlling factors for the occurrence of groundwater. Various thematic layers pertaining to groundwater existence such as geology, geomorphology, land use/land cover, lineament, lineament density, drainage, drainage density, slope, and soil were generated using GIS tools. By integrating all the above thematic layers based on the ranks and

Evidence of elevated pressure and temperature during burial of the Salem Limestone in south-central Indiana, USA, and its implications for surprisingly deep burial

Science.gov (United States)

Ambers, Clifford P.

2001-09-01

A minor, normal fault related to compaction of the grainstone shoal facies of the Salem Limestone in south-central Indiana provides an unusual opportunity to test the pressure and temperature of both faulting and associated stylolitization. Syn-deformational sphalerite occurs in voids along the fault where it intersects an organic-rich shale parting in the sand flat facies overlying the grainstone. The sphalerite contains fluid inclusions that can be used for microthermobaric measurements. Most fluid inclusions in the sphalerite are demonstrably cogenetic with the host sphalerite and of the two-phase aqueous type common in Indiana, although many contain petroleum and others contain gas. Crushing tests in kerosene indicate that the aqueous inclusions contain dissolved methane in varying amounts as high as 1000 ppm. Microthermometry shows that late sphalerite growth, late fault movement, and late stylolitization all occurred as conditions approached 108°C and 292 bars. This pressure is in accord with a normal, basinal, geothermal gradient of 32.5°C/km that would produce the observed temperature under hydrostatic conditions at a burial depth of 2.7 km using an average fluid density of 1.1 g/cm 3. These results serve as a reminder that fluid inclusions in diagenetic minerals hold important temperature and pressure information regarding burial diagenesis of Paleozoic rocks across the North American midcontinent. Detailed study of dissolved gases in fluids trapped in disseminated sphalerite that is common across the midcontinent could help resolve the enigma of sedimentary rocks with high thermal maturity exposed at the surface across the region.

Bulletin of Materials Science | Indian Academy of Sciences

Indian Academy of Sciences (India)

Strontium-incorporated calcium phosphates show potential in biomedical application, particularly the doped strontium may help in new bone formation. ... Department of Chemistry, Periyar University, Salem 636 011, India; Centre for Nanoscience and Nanotechnology, Periyar University, Salem 636 011, India; Department of ...

75 FR 78976 - Procurement List Proposed Addition and Deletions

Science.gov (United States)

2010-12-17

... NSN: 7510-01-555-6167--Inkjet printer cartridge NPA: Alabama Industries for the Blind, Talladega, AL.../Location: Eyewear Prescription Service, Phoenix Indian Medical Center, 4212 N. 16th Street, Phoenix, AZ. NPA: Winston-Salem Industries for the Blind, Winston-Salem, NC. Contracting Activity: Health and Human...

78 FR 73503 - Procurement List Additions and Deletions

Science.gov (United States)

2013-12-06

... by the General Services Administration. NSN: MR 376--Resealable Bags, Holiday, 6.5'' x 5.875''. NSN..., Holiday, 24PC. NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC. Contracting Activity... disabilities, and deletes a product and services from the Procurement List previously furnished by such...

Nõia juurde! Vol.2. / Margit Adorf

Index Scriptorium Estoniae

Adorf, Margit, 1974-

2001-01-01

Mängufilmist "Blairi nõiafilm" ("The Blair Witch Project") : stsenaristid ja režissöörid Eduardo Sanchez ja Daniel Myrick : Ameerika Ühendriigid 1999 ja filmi järjest "Varjude raamat : Blairi nõiafilm 2" ("The Blair Witch Project 2") : Ameerika Ühendriigid 2000

Identification of candidate genes involved in Witches' broom disease resistance in a segregating mapping population of Theobroma cacao L. in Brazil.

Science.gov (United States)

Royaert, Stefan; Jansen, Johannes; da Silva, Daniela Viana; de Jesus Branco, Samuel Martins; Livingstone, Donald S; Mustiga, Guiliana; Marelli, Jean-Philippe; Araújo, Ioná Santos; Corrêa, Ronan Xavier; Motamayor, Juan Carlos

2016-02-11

Witches' broom disease (WBD) caused by the fungus Moniliophthora perniciosa is responsible for considerable economic losses for cacao producers. One of the ways to combat WBD is to plant resistant cultivars. Resistance may be governed by a few genetic factors, mainly found in wild germplasm. We developed a dense genetic linkage map with a length of 852.8 cM that contains 3,526 SNPs and is based on the MP01 mapping population, which counts 459 trees from a cross between the resistant 'TSH 1188' and the tolerant 'CCN 51' at the Mars Center for Cocoa Science in Barro Preto, Bahia, Brazil. Seven quantitative trait loci (QTL) that are associated with WBD were identified on five different chromosomes using a multi-trait QTL analysis for outbreeders. Phasing of the haplotypes at the major QTL region on chromosome IX on a diversity panel of genotypes clearly indicates that the major resistance locus comes from a well-known source of WBD resistance, the clone 'SCAVINA 6'. Various potential candidate genes identified within all QTL may be involved in different steps leading to disease resistance. Preliminary expression data indicate that at least three of these candidate genes may play a role during the first 12 h after infection, with clear differences between 'CCN 51' and 'TSH 1188'. We combined the information from a large mapping population with very distinct parents that segregate for WBD, a dense set of mapped markers, rigorous phenotyping capabilities and the availability of a sequenced genome to identify several genomic regions that are involved in WBD resistance. We also identified a novel source of resistance that most likely comes from the 'CCN 51' parent. Thanks to the large population size of the MP01 population, we were able to pick up QTL and markers with relatively small effects that can contribute to the creation and selection of more tolerant/resistant plant material.

A phytoplasma closely related to the pigeon pea witches'-broom phytoplasma (16Sr IX) is associated with citrus huanglongbing symptoms in the state of São Paulo, Brazil.

Science.gov (United States)

Teixeira, D C; Wulff, N A; Martins, E C; Kitajima, E W; Bassanezi, R; Ayres, A J; Eveillard, S; Saillard, C; Bové, J M

2008-09-01

In February 2007, sweet orange trees with characteristic symptoms of huanglongbing (HLB) were encountered in a region of São Paulo state (SPs) hitherto free of HLB. These trees tested negative for the three liberibacter species associated with HLB. A polymerase chain reaction (PCR) product from symptomatic fruit columella DNA amplifications with universal primers fD1/rP1 was cloned and sequenced. The corresponding agent was found to have highest 16S rDNA sequence identity (99%) with the pigeon pea witches'-broom phytoplasma of group 16Sr IX. Sequences of PCR products obtained with phytoplasma 16S rDNA primer pairs fU5/rU3, fU5/P7 confirm these results. With two primers D7f2/D7r2 designed based on the 16S rDNA sequence of the cloned DNA fragment, positive amplifications were obtained from more than one hundred samples including symptomatic fruits and blotchy mottle leaves. Samples positive for phytoplasmas were negative for liberibacters, except for four samples, which were positive for both the phytoplasma and 'Candidatus Liberibacter asiaticus'. The phytoplasma was detected by electron microscopy in the sieve tubes of midribs from symptomatic leaves. These results show that a phytoplasma of group IX is associated with citrus HLB symptoms in northern, central, and southern SPs. This phytoplasma has very probably been transmitted to citrus from an external source of inoculum, but the putative insect vector is not yet known.

The Empty Seashell

DEFF Research Database (Denmark)

Bubandt, Nils

The Empty Seashell explores what it is like to live in a world where cannibal witches are undeniably real, yet too ephemeral and contradictory to be an object of belief. In a book based on more than three years of fieldwork between 1991 and 2011, Nils Bubandt argues that cannibal witches for people...

CSN's New Emergency Room

International Nuclear Information System (INIS)

Sendin, P.

2005-01-01

During the month of July 2005 the physical renovation works and technological updating of the basic infrastructures of the CSN Emergency Room (SALEM) were finished, allowing the Room to now have greater functionality and a broader technical capacity. Nevertheless, the technological improvement process of SALEM will reach its full potential within the next few years, once the installation currently underway of the new information integration and monitoring systems and the decision making support systems have been completed. This article describes the improvements introduced to the Room and the objectives pursued in this renovation project to convert the SALEM into a new generation room in accordance with its current technological context. (Author) 4 refs

Case report

African Journals Online (AJOL)

abp

2 juil. 2015 ... Page number not for citation purposes. 1. Cancer pulmonaire au cours d'une thromboangéite oblitérante de Léo Buerger. Salem Bouomrani1,&, Alaeddine Slama1, Hanène Nouma1, Maher Béji1. 1Service de Médecine Interne, Hôpital Militaire Gabes, 6000 Tunisie. &Corresponding author: Salem ...

RESEARCH REGARDING THE PURCHASE CONSUMER BEHAVIOR OF TOURISM SERVICES

Directory of Open Access Journals (Sweden)

Simona Cristina Martin

2014-05-01

Full Text Available The service represents nonmaterial solution in solving consumer problems. From this kind of approach arise most features of product policy in provision of services filed. Service is always defined according witch to the needs and requirements of specific groups of consumers, respectively any offer of services witch targets well defined consumer segments, previously established. Per passing day tourism has an increasingly important role in the economy, reason for witch it should be given an special importance of tourism services, which must be analyzed through general features, especially specific ones, to their typology, because, according to these aspects, tourism service providers can provide tourist services that satisfies, at a higher level, consumption needs of the population.

The LIFE Cognition Study: design and baseline characteristics

Directory of Open Access Journals (Sweden)

Sink KM

2014-08-01

Full Text Available Kaycee M Sink,1 Mark A Espeland,2 Julia Rushing,2 Cynthia M Castro,3 Timothy S Church,4 Ronald Cohen,5 Thomas M Gill,6 Leora Henkin,2 Janine M Jennings,7 Diana R Kerwin,8 Todd M Manini,5 Valerie Myers,9 Marco Pahor,5 Kieran F Reid,10 Nancy Woolard,1 Stephen R Rapp,11 Jeff D Williamson1 On behalf of LIFE Investigators 1Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA; 4Pennington Biomedical, Louisiana State University, Baton Rouge, LA, USA; 5Institute on Aging and Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA; 6Yale School of Medicine, Department of Internal Medicine, New Haven, CT, USA; 7Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 8Texas Alzheimer’s and Memory Disorders, Texas Health Presbyterian Hospital Dallas, TX, USA; 9Klein Buendel, Inc., Golden, CO, USA; 10Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA; 11Department of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Observational studies have shown beneficial relationships between exercise and cognitive function. Some clinical trials have also demonstrated improvements in cognitive function in response to moderate–high intensity aerobic exercise; however, these have been limited by relatively small sample sizes and short durations. The Lifestyle Interventions and Independence for Elders (LIFE Study is the largest and longest randomized controlled clinical trial of physical activity with cognitive outcomes, in older sedentary

The evolution of witchcraft and the meaning of healing in colonial Andean society.

Science.gov (United States)

Silverblatt, I

1983-12-01

This paper explores the ways in which traditional beliefs of Andean peoples regarding health and sickness were transformed by the process of Spanish colonization. It also examines how the colonial context devolved new meanings and powers on native curers. The analysis of these transformations in Andean systems of meanings and role structures relating to healing depends on an examination of the European witchcraze of the 16th-17th centuries. The Spanish conquest of the Inca empire in the mid-1500's coincided with the European witch hunts; it is argued that the latter formed the cultural lens through which the Spanish evaluated native religion--the matrix through which Andean concepts of disease and health were expressed--as well as native curers. Andean religion was condemned as heresy and curers were condemned as witches. Traditional Andean cosmology was antithetical to 16th century European beliefs in the struggle between god and the devil, between loyal Christians and the Satan's followers. Consequently, European concepts of disease and health based on the power of witches, Satan's adherents, to cause harm and cure were alien to pre-Columbian Andean thought. Ironically European concepts of Satan and the supposed powers of witches began to graft themselves onto the world view of Andean peoples. The ensuing dialectic of ideas as well as the creation of new healers/witches forged during the imposition of colonial rule form the crux of this analysis.

Animal Models for Testing Antidotes Against an Oral Cyanide Challenge

Science.gov (United States)

2016-08-01

Sources of toxicity and pathology from CN include accidental poisonings from natural or manmade products, fires, suicide, homicide, judicial execution...histotoxic- ( pathological term) hypoxia (Marrs et al., 2007; Gupta, 2009; Ballantyne and Salem, 2005). While normal blood oxygen levels may exist...Group of Taylor and Francis, 313–342. Ballantyne B, Salem, H. (2005). Experimental, clinical, occupational toxicology and forensic aspects of

Military Innovation in the New Normal

Science.gov (United States)

2015-04-13

fundamentally flawed. Having Soldiers with regional affiliation, cultural appreciation, and language proficiency makes sense . The concept simply fails in...36 Recognizing the urgency of this training deficiency, both First and Second Marine Divisions published their respective...Witch Hunt,” http://www.huffingtonpost.com/ sen -barbara- boxer/the-gops-benghazi-witch-h_b_5315857.html (accessed 28 Jan 2015). Military Innovation in

Seasonal variation in biomarker responses of Donax trunculus from the Gulf of Annaba (Algeria): Implication of metal accumulation in sediments

Science.gov (United States)

Amira, Akila; Merad, Isma; Almeida, C. Marisa R.; Guimarães, Laura; Soltani, Nourredine

2018-05-01

The aim of the present study was to test biomarker responses in an edible mollusk, Donax trunculus L. (Mollusca, Bivalvia) associated with environmental pollution in the Gulf of Annaba (northeastern Algeria). The biomarkers selected were glutathione S-transferase (GST), acetylcholinesterase (AChE) and metallothioneins (MTs). Samples were collected seasonally (September 2014, and January, April and July 2015) from two sites located over the Gulf of Annaba: El Battah and Sidi Salem. The results obtained reveal that autumn and winter were the two seasons that show an increase in GST activity, an inhibition of AChE activity and a high rate of MT. In addition, a decrease in AChE activity, an increase in both GST activity and MT levels in D. Trunculus collected from Sidi Salem in comparison with those of El Battah were observed. The biomarker responses at the Sidi Salem site reflect the presence of certain pro-oxidative compounds such as metals (Cd, Cu, Pb, Zn, Mn and Fe) determined in sediments in winter (January) 2015. Moreover, metal concentrations, except Fe, were higher at Sidi Salem than at El Battah. Overall, the Gulf of Annaba remains contaminated by heavy metal. However, this metallic contamination is relatively low and the risks for local population via this edible species were also low.

Air Force and Diversity: The Awkward Embrace

Science.gov (United States)

2013-02-14

people of color into their training films .60 The Air Force will stagnate in its diversity efforts without an in-depth review and overhaul of...December 2012 to ensure workspaces reflected a professional workspace. These were depicted as a “ witch hunt” against the fighter pilot culture; General...Welsh countered vehemently, stating certain traditions had no place in today’s Air Force. Nevertheless, discussions regarding witch hunts are still

Summer Faculty Research Program (SFRP) (1992). Volume 1. Program Management Report.

Science.gov (United States)

1992-12-01

for expenses (i.e., for their to/from trip, privately owned automobile mileage at ($0.25) per mile). A rental-car’s cost is not an authorized...Professor SPECIALTY: Psychology Dept of Social Sciences LABORATORY: AL/ HRM Winston-Salem State University Winston-Salem, NC 27110 Robert J. Turnbull DEGREE...Psychology Dept of Psychology LABORATORY: AL/ HRM Columbus, OH 43210-1222 Ronald L. O(l{svor DEGREE: "S Ohio State University SPECIALTY: Electrical

Development of an Active Topical Skin Protectant (aTSP)

Science.gov (United States)

2016-02-01

protectant as a follow-on product to Skin Exposure Reduction Paste Against Chemical Warfare Agents (SERPACWA). 15. SUBJECT TERMS decontamination , Skin...corresponding author), Chemical Warfare Agent Decontamination from Skin, In J.A. Romano Jr., B.J. Lukey, and H. Salem, eds., 2nd Edition of Chemical Warfare ...CG, and Braue, EH Jr (corresponding author), “ Chemical warfare agent decontamination from skin,” In J.A. Romano Jr., B.J. Lukey, and H. Salem

Evolução da vassoura-de-bruxa e avaliação da resistência em progênies de cupuaçuzeiro Evolution of the witch's broom disease and evaluation of resistance in cupuassu progenies

Directory of Open Access Journals (Sweden)

Rafael Moysés Alves

2009-12-01

Full Text Available Com o objetivo de conhecer a evolução da doença vassoura-de-bruxa, a taxa de segregação e estimar parâmetros genéticos, foi conduzido um experimento com 21 progênies de irmãos completos de cupuaçuzeiro, instalado em Belém, Pará. As progênies foram obtidas pelo cruzamento controlado de clones resistentes com clones resistentes, clones resistentes com clones suscetíveis e, clones suscetíveis com clones suscetíveis. Foram avaliadas também três progênies de meios-irmãos como testemunhas. Os experimentos foram avaliados ao nível de indivíduos, e as análises foram conduzidas via metodologia de modelos lineares mistos (procedimento REMl/BlUP, como delineamento em blocos incompletos desbalanceados, com tratamentos comuns entre dois experimentos. As variáveis avaliadas foram: percentagem de plantas resistentes ao ataque da doença no ramo, inflorescência, fruto imaturo e maduro, no período de 2002 a 2007. Os resultados mostraram que a emissão de vassoura vegetativa é especialmente importante entre julho e setembro. A evolução da doença evidencia que as podas fitossanitárias devem ser realizadas no final da safra, nos meses de maio/junho, e repassadas em setembro/outubro. A população estudada oferece excelente possibilidade de seleção e ganho genético, respaldada pelos elevados índices de variabilidade genética e herdabilidade dos caracteres de resistência. As progênies segregaram tanto para os sintomas de vassoura nos ramos, nas inflorescências, como nos frutos imaturos e maduros. Para o controle integrado desta doença, os resultados mostram a importância da associação de materiais genéticos resistentes ou moderadamente resistentes à vassoura-de-bruxa com as podas fitossanitárias.This paper aimed to study the evolution and individual segregation of the witch's broom disease and estimate the genetic parameters in trials with 21 full sib families of Cupuaçú established in Belém, Pará. The progenies were

SVEN: Informative Visual Representation of Complex Dynamic Structure

Science.gov (United States)

2014-12-23

the dialogue in two well known Shakespeare plays2. 0 1 2 3 4 DEMETRIUS DEMETRIUS LYSANDER LYSANDER HERMIA HERMIA OBERON OBERON HELENA HELENA PUCK PUCK...WITCH LORDS SECOND WITCH SERVANT THIRD APPARITION MENTEITH (b) Figure 10: Dialogue from Shakespeare plays. (a) Midsummer Night’s Dream (b) Macbeth 6...highlighting close friendships and changing groups. Finally, SVEN was used to show the sequence of speakers in two well known Shakespeare plays. Much future

A unique virulence factor for proliferation and dwarfism in plants identified from a phytopathogenic bacterium

OpenAIRE

Hoshi, Ayaka; Oshima, Kenro; Kakizawa, Shigeyuki; Ishii, Yoshiko; Ozeki, Johji; Hashimoto, Masayoshi; Komatsu, Ken; Kagiwada, Satoshi; Yamaji, Yasuyuki; Namba, Shigetou

2009-01-01

One of the most important themes in agricultural science is the identification of virulence factors involved in plant disease. Here, we show that a single virulence factor, tengu-su inducer (TENGU), induces witches' broom and dwarfism and is a small secreted protein of the plant-pathogenic bacterium, phytoplasma. When tengu was expressed in Nicotiana benthamiana plants, these plants showed symptoms of witches' broom and dwarfism, which are typical of phytoplasma infection. Transgenic Arabidop...

On nuclear power plant uprating

International Nuclear Information System (INIS)

Ho, S. Allen; Bailey, James V.; Maginnis, Stephen T.

2004-01-01

Power uprating for commercial nuclear power plants has become increasingly attractive because of pragmatic reasons. It provides quick return on investment and competitive financial benefits, while involving low risks regarding plant safety and public objection. This paper briefly discussed nuclear plant uprating guidelines, scope for design basis analysis and engineering evaluation, and presented the Salem nuclear power plant uprating study for illustration purposes. A cost and benefit evaluation of the Salem power uprating was also included. (author)

Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center

Science.gov (United States)

Detweiler, Mark B.; Pagadala, Bhuvaneshwar; Candelario, Joseph; Boyle, Jennifer S.; Detweiler, Jonna G.; Lutgens, Brian W.

2016-01-01

The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examined the efficacy of various medications used in actual treatment of PTSD nightmares at one Veteran Affairs Hospital. Records at the Salem, VA Veterans Affairs Medical Center (VAMC) were examined from 2009 to 2013 to check for the efficacy of actual treatments used in comparis.on with treatments suggested in three main review articles. The final sample consisted of 327 patients and 478 separate medication trials involving 21 individual medications plus 13 different medication combinations. The three most frequently utilized medications were prazosin (107 trials), risperidone (81 trials), and quetiapine (72 trials). Five medications had 20 or more trials with successful results (partial to full nightmare cessation) in >50% of trials: risperidone (77%, 1.0–6.0 mg), clonidine (63%, 0.1–2.0 mg), quetiapine (50%, 12.5–800.0 mg), mirtazapine (50%; 7.5–30.0 mg), and terazosin (64%, 50.0–300.0 mg). Notably, olanzapine (2.5–10.0) was successful (full remission) in all five prescription trials in five separate patients. Based on the clinical results, the use of risperidone, clonidine, terazosin, and olanzapine warrants additional investigation in clinically controlled trials as medications prescribed specifically for PTSD nightmares. PMID:27999253

Clinical Trials

Medline Plus

Full Text Available ... Trial Protocol Each clinical trial has a master plan called a protocol (PRO-to-kol). This plan explains how the trial will work. The trial ... clinical trial; and detailed information about the treatment plan. Eligibility Criteria A clinical trial's protocol describes what ...

Clinical Trials

Medline Plus

Full Text Available ... Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, or ... humans. What Are Clinical Trials? Clinical trials are research studies that explore whether a medical strategy, treatment, or ...

Body as Danger: Gender, Race and Body in Toni Morrison's Sul

Directory of Open Access Journals (Sweden)

Pi-hua Ni

2015-01-01

Full Text Available http://dx.doi.org/10.5007/2175-8026.2015v68n2p115 This paper aims at tackling the question as to why Sula as a social nonconformist and sexual dissident ends up as an avatar of evil, a powerless victim of witch-hunt and eventually a scapegoat for the decline and misfortunes of her community. To facilitate this critical task, this paper shall irst apply Michel Foucault’s genealogy of “the body as the bearer of pleasure and desire” as laid out in Abnormal to illustrate that Christian folks in Sula’s community interpret Sula’s nonconformity as evil and treat her as a danger to their social order. Thus, this paper argues that the black folks’ ostracism of Sula betokens their mass hysteria and witch-hunt to exorcise their community of danger and evil. Moreover, this paper suggests that Sula is gendered and racialized as a black witch and symbolically executed. In conclusion, this paper contends that an identiication of body with lesh, a phallocentric gender ideology and race bias converge into the black folk’s association of Sula with a witch and a danger and their subsequent victimization of sula as a scapegoat for all the misfortunes of their community.

The Egyptian Military Elite: An Operational Code

Science.gov (United States)

1977-09-01

17 Jan 1955. 6. Salem, Major Salah, "Mehalla’s Great Welcome For Major Salem," Egyptian Gazette, p. 1, 7 Jan 1955. 7. Muhieldin, Lt. Col. Zakaria, "The...Wheel of Reform Will Not Turn Back," Egyptian Gazette, p. 1, 26 Jan 1955. 8. Gohar, Lt. Col. Salah, "Imaginary Incident Explored," Egyptian Gazette...Says Army is Fully Prepared," Al Akhbar , FBIS Vol. 172, p. Al, 4 Sept 1956. 12. Sadat, Anwar al, "Western Powers Determined to Grab Canal," Al

Center-Within-Trial Versus Trial-Level Evaluation of Surrogate Endpoints

Science.gov (United States)

Renfro, Lindsay A.; Shi, Qian; Xue, Yuan; Li, Junlong; Shang, Hongwei; Sargent, Daniel J.

2014-01-01

Evaluation of candidate surrogate endpoints using individual patient data from multiple clinical trials is considered the gold standard approach to validate surrogates at both patient and trial levels. However, this approach assumes the availability of patient-level data from a relatively large collection of similar trials, which may not be possible to achieve for a given disease application. One common solution to the problem of too few similar trials involves performing trial-level surrogacy analyses on trial sub-units (e.g., centers within trials), thereby artificially increasing the trial-level sample size for feasibility of the multi-trial analysis. To date, the practical impact of treating trial sub-units (centers) identically to trials in multi-trial surrogacy analyses remains unexplored, and conditions under which this ad hoc solution may in fact be reasonable have not been identified. We perform a simulation study to identify such conditions, and demonstrate practical implications using a multi-trial dataset of patients with early stage colon cancer. PMID:25061255

Peroxynitrite scavenging activity of herb extracts.

Science.gov (United States)

Choi, Hye Rhi; Choi, Jae Sue; Han, Yong Nam; Bae, Song Ja; Chung, Hae Young

2002-06-01

Peroxynitrite (ONOO(-)) is a cytotoxicant with strong oxidizing properties toward various cellular constituents, including sulphydryls, lipids, amino acids and nucleotides and can cause cell death, lipid peroxidation, carcinogenesis and aging. The aim of this study was to characterize ONOO(-) scavenging constituents from herbs. Twenty-eight herbs were screened for their ONOO(-) scavenging activities with the use of a fluorometric method. The potency of scavenging activity following the addition of authentic ONOO(-) was in the following order: witch hazel bark > rosemary > jasmine tea > sage > slippery elm > black walnut leaf > Queen Anne's lace > Linden flower. The extracts exhibited dose-dependent ONOO(-) scavenging activities. We found that witch hazel (Hamamelis virginiana L.) bark showed the strongest effect for scavenging ONOO(-) of the 28 herbs. Hamamelitannin, the major active component of witch hazel bark, was shown to have a strong ability to scavenge ONOO(-). It is suggested that hamamelitannin might be developed as an effective peroxynitrite scavenger for the prevention of ONOO(-) involved diseases. Copyright 2002 John Wiley & Sons, Ltd.

Clinical Trials

Medline Plus

Full Text Available ... take part in a clinical trial. When researchers think that a trial's potential risks are greater than ... care costs for clinical trials. If you're thinking about taking part in a clinical trial, find ...

Clinical Trials

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Full Text Available ... to-kol). This plan explains how the trial will work. The trial is led by a principal ... for the clinical trial. The protocol outlines what will be done during the clinical trial and why. ...

Clinical Trials

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Full Text Available ... questions and clinical trials. Optimizing our Clinical Trials Enterprise NHLBI has a strong tradition of supporting clinical ... multi-pronged approach to Optimize our Clinical Trials Enterprise that will make our clinical trials enterprise even ...

Clinical Trials

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Full Text Available ... of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are ... earlier than they would be in general medical practice. This is because late-phase trials have large ...

Clinical Trials

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... kol). This plan explains how the trial will work. The trial is led by a principal investigator ( ...

Clinical Trials

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Full Text Available ... clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a ... will be done during the clinical trial and why. Each medical center that does the study uses ...

Clinical Trials

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Full Text Available ... medical strategy, treatment, or device is safe and effective for humans. What Are Clinical Trials? Clinical trials ... and Centers sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include ...

Uncertainty analysis in calculations of a road accident consequences

International Nuclear Information System (INIS)

Bonnefous, S.; Brenot, J.; Hubert, P.

1995-01-01

This paper develops a concrete situation witch is the search for an evacuation distance in case of a road accident implying a chlorine tank. The methodological aspect is how implementing uncertainty analysis in deterministic models with random parameters. The study demonstrates a great dispersion in the results. It allows to establish satisfactory decision rules and a hierarchy on parameters witch is useful to define priorities in the search for information and to improve the treatment of these parameters. (authors). 8 refs., 1 fig., 2 tabs

Remune trial will stop; new trials planned.

Science.gov (United States)

James, J S

1999-05-21

A clinical trial using remune, the anti-HIV vaccine developed by the late Dr. Jonas Salk, has been ended. The study is a clinical-endpoint trial which looks for statistically significant differences in AIDS sickness or death between patients who add remune to their treatment regimens versus those who use a placebo. Agouron Pharmaceuticals and the Immune Response Corporation who were conducting the trial announced their decision to stop it after an analysis by the Data Safety Monitoring Board. No differences in clinical endpoints were found and it was projected that continuing the trial would likely not find any. The companies are now planning two new Phase III trials using viral load testing rather than clinical endpoints as study criteria.

Clinical Trials

Medline Plus

Full Text Available ... of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a key ... Enterprise NHLBI has a strong tradition of supporting clinical trials that have not only shaped medical practice around the world, but have improved the health ...

Accountability: a missing construct in models of adherence behavior and in clinical practice

Directory of Open Access Journals (Sweden)

Oussedik E

2017-07-01

Full Text Available Elias Oussedik,1 Capri G Foy,2 E J Masicampo,3 Lara K Kammrath,3 Robert E Anderson,1 Steven R Feldman1,4,5 1Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 2Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; 3Department of Psychology, Wake Forest University, Winston-Salem, NC, USA; 4Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA; 5Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA Abstract: Piano lessons, weekly laboratory meetings, and visits to health care providers have in common an accountability that encourages people to follow a specified course of action. The accountability inherent in the social interaction between a patient and a health care provider affects patients’ motivation to adhere to treatment. Nevertheless, accountability is a concept not found in adherence models, and is rarely employed in typical medical practice, where patients may be prescribed a treatment and not seen again until a return appointment 8–12 weeks later. The purpose of this paper is to describe the concept of accountability and to incorporate accountability into an existing adherence model framework. Based on the Self-Determination Theory, accountability can be considered in a spectrum from a paternalistic use of duress to comply with instructions (controlled accountability to patients’ autonomous internal desire to please a respected health care provider (autonomous accountability, the latter expected to best enhance long-term adherence behavior. Existing adherence models were reviewed with a panel of experts, and an accountability construct was incorporated into a modified version of Bandura’s Social Cognitive Theory. Defining accountability and incorporating it into an adherence model will facilitate the development of measures of accountability as well

Clinical Trials

Medline Plus

Full Text Available ... clinical trials. If you're thinking about taking part in a clinical trial, find out ahead of time about costs and coverage. You should learn about the risks and benefits of any clinical trial before you agree to take part in the trial. Talk with your doctor about ...

Western oil companies in the eighties and nineties: from multi-nationalization to globalization?; Les compagnies petrolieres occidentales dans les decennies quatre-vingt et quatre-vingt-dix: de la multinationalisation a la globalisation?

Energy Technology Data Exchange (ETDEWEB)

Bourgeois, B. [Grenoble-1 Univ., 38 (France)

1997-12-31

Ways and intensity of trans-nationalization process of Western oil companies have dramatically changed over the last thirty years. After a decline from 1970 to 1984, a new era of investment extraversion from home base is developing. We discuss then the extent to witch this new era is a part of a larger process of firms globalization interacting witch political internationalization. The existence of a clear globalization trend is recognized inside the oil industry, but with a persisting specificity coming from the access conditions to the oil deposits. (author)

Evaluation of three levels of selective devices relevant to management of the Danish Kattegat-Skagerrak Nephrops fishery

DEFF Research Database (Denmark)

Frandsen, Rikke; Holst, René; Madsen, Niels

2009-01-01

This study illuminates a range of technological options relevant to present legislation for regulating fish by-catch in a small-meshed Nephrops fishery. The selection of cod, haddock, hake, lemon sole, Nephrops, plaice, saithe, witch, and whiting were evaluated using the twin-trawl technique for...... parameters by species and confidence bands to compare the selective properties of different gear types. For cod, haddock, hake, Nephrops, plaice, and whiting we obtained estimates for all three gear variants, whereas we obtained estimates for lemon sole and witch only with the standard and the SMP codends...

Inferring fish escape behaviour in trawls based on catch comparison data: Model development and evaluation based on data from Skagerrak, Denmark

DEFF Research Database (Denmark)

Krag, Ludvig Ahm; Herrmann, Bent; Karlsen, Junita Diana

2014-01-01

), haddock Melanogrammus aeglefinus), saithe (Pollachius virens), witch flounder (Glyptocephalus cynoglossus), and lemon sole (Microstomus kitt) and quantified the extent to which behavioural responses set limits for the large mesh panel’s selective efficiency. Around 85% of saithe, 80% of haddock, 44......% of witch flounder, 55% of lemon sole, and 55% of cod (below 68 cm) contacted the large mesh panel and escaped. We also demonstrated the need to account for potential selectivity in the trawl body, as it can bias the assessment of length-based escape behaviour. Our indirect assessment of fish behaviour...

Clinical Trials

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Full Text Available ... need to travel or stay in hospitals to take part in clinical trials. For example, the National Institutes of Health Clinical Center in ... Maryland, runs clinical trials. Many other clinical trials take place in medical centers and ... trial can have many benefits. For example, you may gain access to new treatments before ...

Physical activity and trial-by-trial adjustments of response conflict.

Science.gov (United States)

Kamijo, Keita; Takeda, Yuji

2013-08-01

The relationship of physical activity to trial-by-trial adjustments of response conflict was assessed using behavioral task performance, the N2 event-related brain potential component, and phase-locking values (PLVs) in a lower gamma band during a perceptual conflict task. Nineteen physically active and 19 inactive young adults (mean age = 21.3 years) performed a Navon task, using a global letter made up of local letters of either the same kind (congruent trials) or a different kind (incongruent trials). Findings revealed that active individuals exhibited smaller N2 amplitudes and greater PLVs on incongruent trials that were preceded by incongruent trials compared with those preceded by congruent trials. Such phenomena were not observed for inactive individuals. These results suggest that greater physical activity is associated with larger trial-by-trial adjustments of response conflict, which we attribute to upregulation of top-down cognitive control and reductions in response conflict.

Clinical trials in dentistry in India: Analysis from trial registry.

Science.gov (United States)

Gowri, S; Kannan, Sridharan

2017-01-01

Evidence-based practice requires clinical trials to be performed. In India, if any clinical trial has to be performed, it has to be registered with clinical trial registry of India. Studies have shown that the report of clinical trials is poor in dentistry. Hence, the present study has been conducted to assess the type and trends of clinical trials being undertaken in dentistry in India over a span of 6 years. All the clinical trials which were registered with the Central Trial Registry of India (CTRI) (www.ctri.nic.in) from January 1, 2007 to March 3, 2014 were evaluated using the keyword "dental." Following information were collected for each of the clinical trials obtained from the search; number of centres (single center/multicentric), type of the institution undertaking the research (government/private/combined), study (observational/interventional), study design (randomized/single blinded/double-blinded), type of health condition, type of participants (healthy/patients), sponsors (academia/commercial), phase of clinical trial (Phase 1/2/3/4), publication details (published/not published), whether it was a postgraduate thesis or not and prospective or retrospective registration of clinical trials, methodological quality (method of randomization, allocation concealment). Descriptive statistics was used for analysis of various categories. Trend analysis was done to assess the changes over a period of time. The search yielded a total of 84 trials of which majority of them were single centered. Considering the study design more than half of the registered clinical trials were double-blinded (47/84 [56%]). With regard to the place of conducting a trial, most of the trials were planned to be performed in private hospitals (56/84 [66.7%]). Most (79/84, 94.1%) of the clinical trials were interventional while only 5/84 (5.9%) were observational. Majority (65/84, 77.4%) of the registered clinical trials were recruiting patients while the rest were being done in healthy

Recruitment to publicly funded trials--are surgical trials really different?

Science.gov (United States)

Cook, Jonathan A; Ramsay, Craig R; Norrie, John

2008-09-01

Good recruitment is integral to the conduct of a high-quality randomised controlled trial. It has been suggested that recruitment is particularly difficult for evaluations of surgical interventions, a field in which there is a dearth of evidence from randomised comparisons. While there is anecdotal speculation to support the inference that recruitment to surgical trials is more challenging than for medical trials we are unaware of any formal assessment of this. In this paper, we compare recruitment to surgical and medical trials using a cohort of publicly funded trials. Overall recruitment to trials was assessed using of a cohort of publicly funded trials (n=114). Comparisons were made by using the Recruitment Index, a simple measure of recruitment activity for multicentre randomised controlled trials. Recruitment at the centre level was also investigated through three example surgical trials. The Recruitment Index was found to be higher, though not statistically significantly, in the surgical group (n=18, median=38.0 IQR (10.7, 77.4)) versus (n=81, median=34.8 IQR (11.7, 98.0)) days per recruit for the medical group (median difference 1.7 (-19.2, 25.1); p=0.828). For the trials where the comparison was between a surgical and a medical intervention, the Recruitment Index was substantially higher (n=6, 68.3 (23.5, 294.8)) versus (n=93, 34.6 (11.7, 90.0); median difference 25.9 (-35.5, 221.8); p=0.291) for the other trials. There was no clear evidence that surgical trials differ from medical trials in terms of recruitment activity. There was, however, support for the inference that medical versus surgical trials are more difficult to recruit to. Formal exploration of the recruitment data through a modelling approach may go some way to tease out where important differences exist.

Impact of a cancer clinical trials web site on discussions about trial participation: a cluster randomized trial.

Science.gov (United States)

Dear, R F; Barratt, A L; Askie, L M; Butow, P N; McGeechan, K; Crossing, S; Currow, D C; Tattersall, M H N

2012-07-01

Cancer patients want access to reliable information about currently recruiting clinical trials. Oncologists and their patients were randomly assigned to access a consumer-friendly cancer clinical trials web site [Australian Cancer Trials (ACT), www.australiancancertrials.gov.au] or to usual care in a cluster randomized controlled trial. The primary outcome, measured from audio recordings of oncologist-patient consultations, was the proportion of patients with whom participation in any clinical trial was discussed. Analysis was by intention-to-treat accounting for clustering and stratification. Thirty medical oncologists and 493 patients were recruited. Overall, 46% of consultations in the intervention group compared with 34% in the control group contained a discussion about clinical trials (P=0.08). The mean consultation length in both groups was 29 min (P=0.69). The proportion consenting to a trial was 10% in both groups (P=0.65). Patients' knowledge about randomized trials was lower in the intervention than the control group (mean score 3.0 versus 3.3, P=0.03) but decisional conflict scores were similar (mean score 42 versus 43, P=0.83). Good communication between patients and physicians is essential. Within this context, a web site such as Australian Cancer Trials may be an important tool to encourage discussion about clinical trial participation.

‘Getting tested is almost like going to the Salem witch trials’: Discordant discourses between western public health messages and sociocultural expectations surrounding HIV testing among East African immigrant women

Science.gov (United States)

DE JESUS, Maria; CARRETE, Claudia; MAINE, Cathleen; NALLS, Patricia

2015-01-01

Washington, DC has the highest AIDS diagnosis rate in the United States and Black women are disproportionately affected. Although HIV testing is the first entryway into vital treatment services, evidence reveals that foreign-born blacks have a lower rate of recent HIV testing than U.S.-born blacks. To date, however, there are no studies that examine the culture-specific perceptions of HIV testing among East African immigrant women (who comprise a large share of Black Africans in DC) to better understand their potential barriers to testing. Adopting the PEN-3 cultural model as our theoretical framework, the main objective of this study was to examine East African women’s HIV testing perceptions and partner communication norms. Between October 2012 and March 2013, trained interviewers conducted a total of 25 interviews with East African women in the Washington DC Metropolitan area. For triangulation purposes, data collection consisted of both in-depth, semi-structured interviews and cognitive interviews, in which participants were administered a quantitative survey and assessed on how they interpreted items. Qualitative thematic analysis revealed a systematic pattern of discordant responses across participants. While they were aware of messages related to western public health discourse surrounding HIV testing (e.g., Everyone should get tested for HIV; One should talk to one’s spouse about HIV testing), divergent sociocultural expectations rooted in cultural and religious beliefs prevailed (e.g., Getting an HIV test brings shame to the person who got tested and to one’s family; it implies one is engaging in immoral behavior; One should not talk with one’s spouse about HIV testing; doing so breaks cultural norms). Implications of using a culture-centered model to examine the role of sociocultural expectations in HIV prevention research and to develop culturally responsive prevention strategies are discussed. PMID:25616443

Reduction of robot base parameters

International Nuclear Information System (INIS)

Vandanjon, P.O.

1995-01-01

This paper is a new step in the search of minimum dynamic parameters of robots. In spite of planing exciting trajectories and using base parameters, some parameters remain not identifiable due to the perturbation effects. In this paper, we propose methods to reduce the set of base parameters in order to get an essential set of parameters. This new set defines a simplified identification model witch improves the noise immunity of the estimation process. It contributes also in reducing the computation burden of a simplified dynamic model. Different methods are proposed and are classified in two parts: methods, witch perform reduction and identification together, come from statistical field and methods, witch reduces the model before the identification thanks to a priori information, come from numerical field like the QR factorization. Statistical tools and QR reduction are shown to be efficient and adapted to determine the essential parameters. They can be applied to open-loop, or graph structured rigid robot, as well as flexible-link robot. Application for the PUMA 560 robot is given. (authors). 9 refs., 4 tabs

Reduction of robot base parameters

Energy Technology Data Exchange (ETDEWEB)

Vandanjon, P O [CEA Centre d` Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Procedes et Systemes Avances; Gautier, M [Nantes Univ., 44 (France)

1996-12-31

This paper is a new step in the search of minimum dynamic parameters of robots. In spite of planing exciting trajectories and using base parameters, some parameters remain not identifiable due to the perturbation effects. In this paper, we propose methods to reduce the set of base parameters in order to get an essential set of parameters. This new set defines a simplified identification model witch improves the noise immunity of the estimation process. It contributes also in reducing the computation burden of a simplified dynamic model. Different methods are proposed and are classified in two parts: methods, witch perform reduction and identification together, come from statistical field and methods, witch reduces the model before the identification thanks to a priori information, come from numerical field like the QR factorization. Statistical tools and QR reduction are shown to be efficient and adapted to determine the essential parameters. They can be applied to open-loop, or graph structured rigid robot, as well as flexible-link robot. Application for the PUMA 560 robot is given. (authors). 9 refs., 4 tabs.

Clinical Trials

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Full Text Available ... criteria differ from trial to trial. They include factors such as a patient's age and gender, the ... bias. "Bias" means that human choices or other factors not related to the protocol affect the trial's ...

Clinical Trials

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Full Text Available ... Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, or ... and Clinical Studies Web page. Children and Clinical Studies Learn more about Children and Clinical Studies Importance ...

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Full Text Available ... more information about eligibility criteria, go to "How Do Clinical Trials Work?" Some trials enroll people who ... for adults. For more information, go to "How Do Clinical Trials Protect Participants?" For more information about ...

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Full Text Available ... or vulnerable patients (such as children). A DSMB's role is to review data from a clinical trial ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

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Full Text Available ... clinical trials are vital to the process of improving medical care. Many people volunteer because they want ... care costs for clinical trials. If you're thinking about taking part in a clinical trial, find ...

Clinical Trials

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Full Text Available ... protocol affect the trial's results. Comparison Groups In most clinical trials, researchers use comparison groups. This means ... study before you agree to take part. Randomization Most clinical trials that have comparison groups use randomization. ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... from a study at any time, for any reason. Also, during the trial, you have the right ...

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Full Text Available ... you agree to take part in the trial. Talk with your doctor about specific trials you're ... part in a clinical trial is your decision. Talk with your doctor about all of your treatment ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... study? How might this trial affect my daily life? Will I have to be in the hospital? ...

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Full Text Available ... any clinical trial before you agree to take part in the trial. Talk with your doctor about specific trials you're interested in. For a list of questions to ask your doctor and the ...

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Full Text Available ... or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research studies ... parents, clinicians, researchers, children, and the general public. What to Expect During a clinical trial, doctors, nurses, ...

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Full Text Available ... under way. For example, some trials are stopped early if benefits from a strategy or treatment are ... stop a trial, or part of a trial, early if the strategy or treatment is having harmful ...

Clinical Trials

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Full Text Available ... Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, ... required to have an IRB. Office for Human Research Protections The U.S. Department of Health and Human ...

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Full Text Available ... Health Topics / About Clinical Trials About Clinical Trials Clinical trials are research studies that explore whether a medical strategy, treatment, ... tool for advancing medical knowledge and patient care. Clinical research is done only if doctors don't know ...

Trial publication after registration in ClinicalTrials.Gov: a cross-sectional analysis.

Directory of Open Access Journals (Sweden)

Joseph S Ross

2009-09-01

Full Text Available ClinicalTrials.gov is a publicly accessible, Internet-based registry of clinical trials managed by the US National Library of Medicine that has the potential to address selective trial publication. Our objectives were to examine completeness of registration within ClinicalTrials.gov and to determine the extent and correlates of selective publication.We examined reporting of registration information among a cross-section of trials that had been registered at ClinicalTrials.gov after December 31, 1999 and updated as having been completed by June 8, 2007, excluding phase I trials. We then determined publication status among a random 10% subsample by searching MEDLINE using a systematic protocol, after excluding trials completed after December 31, 2005 to allow at least 2 y for publication following completion. Among the full sample of completed trials (n = 7,515, nearly 100% reported all data elements mandated by ClinicalTrials.gov, such as intervention and sponsorship. Optional data element reporting varied, with 53% reporting trial end date, 66% reporting primary outcome, and 87% reporting trial start date. Among the 10% subsample, less than half (311 of 677, 46% of trials were published, among which 96 (31% provided a citation within ClinicalTrials.gov of a publication describing trial results. Trials primarily sponsored by industry (40%, 144 of 357 were less likely to be published when compared with nonindustry/nongovernment sponsored trials (56%, 110 of 198; p<0.001, but there was no significant difference when compared with government sponsored trials (47%, 57 of 122; p = 0.22. Among trials that reported an end date, 75 of 123 (61% completed prior to 2004, 50 of 96 (52% completed during 2004, and 62 of 149 (42% completed during 2005 were published (p = 0.006.Reporting of optional data elements varied and publication rates among completed trials registered within ClinicalTrials.gov were low. Without greater attention to reporting of all data

Witchcraft Beliefs and Witch Hunts

NARCIS (Netherlands)

Koning, N.B.J.

2013-01-01

This paper proposes an interdisciplinary explanation of the cross-cultural similarities and evolutionary patterns of witchcraft beliefs. It argues that human social dilemmas have led to the evolution of a fear system that is sensitive to signs of deceit and envy. This was adapted in the evolutionary

Clinical Trials

Medline Plus

Full Text Available ... child to enroll. Also, children aged 7 and older often must agree (assent) to take part in clinical trials. Clinical trials for children have the same scientific safeguards as clinical trials for adults. For more information, go to "How Do Clinical ...

Clinical Trials

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Full Text Available ... give permission for their child to enroll. Also, children aged 7 and older often must agree (assent) to take part in clinical trials. Find a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

Managing clinical trials

Directory of Open Access Journals (Sweden)

Kenyon Sara

2010-07-01

Full Text Available Abstract Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evaluated or published to guide new trialists starting out in this important field. For the past three decades, trialists have invented and reinvented the trial management wheel. We suggest that to improve the successful, timely delivery of important clinical trials for patient benefit, it is time to produce standard trial management guidelines and develop robust methods of evaluation.

Space-charge effects in Penning ion traps

Science.gov (United States)

Porobić, T.; Beck, M.; Breitenfeldt, M.; Couratin, C.; Finlay, P.; Knecht, A.; Fabian, X.; Friedag, P.; Fléchard, X.; Liénard, E.; Ban, G.; Zákoucký, D.; Soti, G.; Van Gorp, S.; Weinheimer, Ch.; Wursten, E.; Severijns, N.

2015-06-01

The influence of space-charge on ion cyclotron resonances and magnetron eigenfrequency in a gas-filled Penning ion trap has been investigated. Off-line measurements with K39+ using the cooling trap of the WITCH retardation spectrometer-based setup at ISOLDE/CERN were performed. Experimental ion cyclotron resonances were compared with ab initio Coulomb simulations and found to be in agreement. As an important systematic effect of the WITCH experiment, the magnetron eigenfrequency of the ion cloud was studied under increasing space-charge conditions. Finally, the helium buffer gas pressure in the Penning trap was determined by comparing experimental cooling rates with simulations.

Clinical Trials

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Full Text Available ... more screening tests to see which test produces the best results. Some companies and groups sponsor clinical trials that test the ... and Drug Administration (FDA) oversees these clinical trials. The NIH may partner with these companies or groups to help sponsor some trials. All ...

Clinical Trials

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Full Text Available ... resources to the strategies and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, you may get tests or treatments in a hospital, clinic, or doctor's office. In some ways, taking part in a clinical trial is different ...

Clinical trials of homoeopathy.

Science.gov (United States)

Kleijnen, J; Knipschild, P; ter Riet, G

1991-01-01

OBJECTIVE--To establish whether there is evidence of the efficacy of homoeopathy from controlled trials in humans. DESIGN--Criteria based meta-analysis. Assessment of the methodological quality of 107 controlled trials in 96 published reports found after an extensive search. Trials were scored using a list of predefined criteria of good methodology, and the outcome of the trials was interpreted in relation to their quality. SETTING--Controlled trials published world wide. MAIN OUTCOME MEASURES--Results of the trials with the best methodological quality. Trials of classical homoeopathy and several modern varieties were considered separately. RESULTS--In 14 trials some form of classical homoeopathy was tested and in 58 trials the same single homoeopathic treatment was given to patients with comparable conventional diagnosis. Combinations of several homoeopathic treatments were tested in 26 trials; isopathy was tested in nine trials. Most trials seemed to be of very low quality, but there were many exceptions. The results showed a positive trend regardless of the quality of the trial or the variety of homeopathy used. Overall, of the 105 trials with interpretable results, 81 trials indicated positive results whereas in 24 trials no positive effects of homoeopathy were found. The results of the review may be complicated by publication bias, especially in such a controversial subject as homoeopathy. CONCLUSIONS--At the moment the evidence of clinical trials is positive but not sufficient to draw definitive conclusions because most trials are of low methodological quality and because of the unknown role of publication bias. This indicates that there is a legitimate case for further evaluation of homoeopathy, but only by means of well performed trials. PMID:1825800

Clinical Trials

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Full Text Available ... about your health or fill out forms about how you feel. Some people will need to travel or stay in hospitals to take part in clinical trials. For example, the National Institutes of Health Clinical Center in Bethesda, Maryland, runs clinical trials. Many other clinical trials take place ...

Clinical Trials

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Full Text Available ... part in a clinical trial is your decision. Talk with your doctor about all of your treatment options. Together, you can make the ... more about, or taking part in, clinical trials, talk with your doctor. He or she may know about ... clinical trials. NIH Clinical Research Studies ...

Using simulation to aid trial design: Ring-vaccination trials.

Directory of Open Access Journals (Sweden)

Matt David Thomas Hitchings

2017-03-01

Full Text Available The 2014-6 West African Ebola epidemic highlights the need for rigorous, rapid clinical trial methods for vaccines. A challenge for trial design is making sample size calculations based on incidence within the trial, total vaccine effect, and intracluster correlation, when these parameters are uncertain in the presence of indirect effects of vaccination.We present a stochastic, compartmental model for a ring vaccination trial. After identification of an index case, a ring of contacts is recruited and either vaccinated immediately or after 21 days. The primary outcome of the trial is total vaccine effect, counting cases only from a pre-specified window in which the immediate arm is assumed to be fully protected and the delayed arm is not protected. Simulation results are used to calculate necessary sample size and estimated vaccine effect. Under baseline assumptions about vaccine properties, monthly incidence in unvaccinated rings and trial design, a standard sample-size calculation neglecting dynamic effects estimated that 7,100 participants would be needed to achieve 80% power to detect a difference in attack rate between arms, while incorporating dynamic considerations in the model increased the estimate to 8,900. This approach replaces assumptions about parameters at the ring level with assumptions about disease dynamics and vaccine characteristics at the individual level, so within this framework we were able to describe the sensitivity of the trial power and estimated effect to various parameters. We found that both of these quantities are sensitive to properties of the vaccine, to setting-specific parameters over which investigators have little control, and to parameters that are determined by the study design.Incorporating simulation into the trial design process can improve robustness of sample size calculations. For this specific trial design, vaccine effectiveness depends on properties of the ring vaccination design and on the

Type 1 Diabetes TrialNet--an international collaborative clinical trials network.

Science.gov (United States)

Skyler, Jay S; Greenbaum, Carla J; Lachin, John M; Leschek, Ellen; Rafkin-Mervis, Lisa; Savage, Peter; Spain, Lisa

2008-12-01

Type 1 Diabetes TrialNet is an international consortium of clinical research centers aimed at the prevention or delay of type 1 diabetes (T1D). The fundamental goal of TrialNet is to counter the T1D disease process by immune modulation and/or enhancement of beta cell proliferation and regeneration. To achieve this goal, TrialNet researchers are working to better understand the natural history of the disease, to identify persons at risk, and to clinically evaluate novel therapies that balance potential risks and benefits. The particular focus is on studies of preventive measures. In addition, TrialNet evaluates therapies in individuals with newly diagnosed T1D with preserved beta cell function to help determine the risk/benefit profile and gain an initial assessment of potential efficacy in preservation of beta cell function, so that promising agents can be studied in prevention trials. In addition, TrialNet evaluates methodologies that enhance the conduct of its clinical trials, which includes tests of outcome assessment methodology, the evaluation of surrogate markers, and mechanistic studies laying the foundation for future clinical trials.

Atmospheric emissions as a tool in evaluation of sustainability research in oil industry; Emissao atmosferica como uma ferramenta na avaliacao do desenvolvimento sustentavel na industria do petroleo

Energy Technology Data Exchange (ETDEWEB)

Zanella, Nicolas P.; Baich, Paulo R.M.; Machado, Maria I. [Fundacao Universidade do Rio Grande (FURG), RS (Brazil)

2008-07-01

This work is directly to analysis of atmosphere surrounding Ipiranga Refinery; witch is located in the city of Rio Grande, in estate of Rio Grande do Sul. The refinery is surrounded by neighborhood, witch are impacted by atmospheric emissions of refinery. The objective of this work is correlating the refinery to the inhabitants that lives near the refinery, using an environmental sustainability index. This work will be achieve by analysis of Polycyclic Aromatic Hydrocarbons (PAH) bounded in particulate matter with diameter of 100 {mu}m (PTS), the acquisition of health data on the city hospitals and correlation of this data with PAH concentrations in Particulate Matter. The Samples were obtain by FEPAM, witch have three samples sites in the center of city. The samples was obtained by a High Volume Sampler equipped with quartz fiber filters. The meteorological data important to this work, like wind direction and speed, will be obtain in Meteorological Station on FURG. The results expect to this work are the quantification of PAH bounded with PM-100 and the quantification of PAH emitted by Ipiranga Refinery. And possibly, to correlate this data to made the Environmental Sustainability index. (author)

Understanding noninferiority trials

Directory of Open Access Journals (Sweden)

Seokyung Hahn

2012-11-01

Full Text Available Noninferiority trials test whether a new experimental treatment is not unacceptably less efficacious than an active control treatment already in use. With continuous improvements in health technologies, standard care, and clinical outcomes, the incremental benefits of newly developed treatments may be only marginal over existing treatments. Sometimes assigning patients to a placebo is unethical. In such circumstances, there has been increasing emphasis on the use of noninferiority trial designs. Noninferiority trials are more complex to design, conduct, and interpret than typical superiority trials. This paper reviews the concept of noninferiority trials and discusses some important issues related to them.

CrossRef Space-charge effects in Penning ion traps

CERN Document Server

Porobić, T; Breitenfeldt, M; Couratin, C; Finlay, P; Knecht, A; Fabian, X; Friedag, P; Fléchard, X; Liénard, E; Ban, G; Zákoucký, D; Soti, G; Van Gorp, S; Weinheimer, Ch; Wursten, E; Severijns, N

2015-01-01

The influence of space-charge on ion cyclotron resonances and magnetron eigenfrequency in a gas-filled Penning ion trap has been investigated. Off-line measurements with View the MathML source using the cooling trap of the WITCH retardation spectrometer-based setup at ISOLDE/CERN were performed. Experimental ion cyclotron resonances were compared with ab initio Coulomb simulations and found to be in agreement. As an important systematic effect of the WITCH experiment, the magnetron eigenfrequency of the ion cloud was studied under increasing space-charge conditions. Finally, the helium buffer gas pressure in the Penning trap was determined by comparing experimental cooling rates with simulations.

Western armament and tactics in the writings of Anna Komnene

Directory of Open Access Journals (Sweden)

Drašković Marko

2006-01-01

Full Text Available In this work, first we reconstructed and commented the western horseman's armament witch Anna Komnene had known (long spear, cross-bow, chain mail "Norman" shield, solarets. Afterwards, we established that Anne knew four types of western horseman's attack (attack in full gallop, attack from back slow march, attack from flank and three types of their battle formation (strewn formation, congested formation, formation of two columns. Also, we commented Anna's knowledge of western siege engines (battering-ram, tortoise catapult, siege tower; we established that Anne knew five types of western siege tower. In the end, we commented several fragments witch show Anna Komnene's knowledge of the western siege tactics.

Understanding Clinical Trials

Science.gov (United States)

Watch these videos to learn about some basic aspects of cancer clinical trials such as the different phases of clinical trials, methods used to protect patient safety, and how the costs of clinical trials are covered.

Developmental changes in the effect of inversion: using a picture book to investigate face recognition.

Science.gov (United States)

Brace, N A; Hole, G J; Kemp, R I; Pike, G E; Van Duuren, M; Norgate, L

2001-01-01

A novel child-oriented procedure was used to examine the face-recognition abilities of children as young as 2 years. A recognition task was embedded in a picture book containing a story about two boys and a witch. The story and the task were designed to be entertaining for children of a wide age range. In eight trials, the children were asked to pick out one of the boys from amongst eight distractors as quickly as possible. Response-time data to both upright and inverted conditions were analysed. The results revealed that children aged 6 years onwards showed the classic inversion effect. By contrast, the youngest children, aged 2 to 4 years, were faster at recognising the target face in the inverted condition than in the upright condition. Several possible explanations for this 'inverted inversion effect' are discussed.

Types of Cancer Clinical Trials

Science.gov (United States)

Information about the several types of cancer clinical trials, including treatment trials, prevention trials, screening trials, supportive and palliative care trials. Each type of trial is designed to answer different research questions.

Conducting clinical trials in Singapore.

Science.gov (United States)

Woo, K T

1999-04-01

All clinical trials in Singapore will now have to conform to the Medicines (Clinical Trials) Amended Regulations 1998 and the Singapore Good Clinical Practice (GCP) Guidelines 1998. The Medical Clinical Research Committee (MCRC) has been established to oversee the conduct of clinical drug trials in Singapore and together with the legislations in place, these will ensure that clinical trials conducted in Singapore are properly controlled and the well-being of trial subjects are safe guarded. All clinical drug trials require a Clinical Trial Certificate from the MCRC before the trial can proceed. The hospital ethics committee (EC) vets the application for a trial certificate before it is sent to MCRC. The drug company sponsoring the trial has to indemnify the trial investigators and the hospital for negligence arising from the trial. The MCRC, apart from ensuring the safety of trial subjects, has to provide continuing review of the clinical trial and monitors adverse events in the course of the trial. The EC will conduct continuing review of clinical trials. When a non-drug clinical trial is carried out, the EC will ensure that the proposed protocol addresses ethical concerns and meets regulatory requirements for such trials. There is great potential for pharmaceutical Research & Development (R&D) in Singapore. We must develop our skills and infrastructure in clinical trials to enable Singapore to be a regional hub for R&D of drugs in Asia.

Trial-to-Trial Fluctuations in Attentional State and Their Relation to Intelligence

Science.gov (United States)

Unsworth, Nash; McMillan, Brittany D.

2014-01-01

Trial-to-trial fluctuations in attentional state while performing measures of intelligence were examined in the current study. Participants performed various measures of fluid and crystallized intelligence while also providing attentional state ratings prior to each trial. It was found that pre-trial attentional state ratings strongly predicted…

Clinical Trials

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Full Text Available ... Entire Site NHLBI Entire Site Health Topics News & Resources Intramural Research ... or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research ...

Linking ClinicalTrials.gov and PubMed to track results of interventional human clinical trials.

Directory of Open Access Journals (Sweden)

Vojtech Huser

Full Text Available OBJECTIVE: In an effort to understand how results of human clinical trials are made public, we analyze a large set of clinical trials registered at ClinicalTrials.gov, the world's largest clinical trial registry. MATERIALS AND METHODS: We considered two trial result artifacts: (1 existence of a trial result journal article that is formally linked to a registered trial or (2 the deposition of a trial's basic summary results within the registry. RESULTS: The study sample consisted of 8907 completed, interventional, phase 2-or-higher clinical trials that were completed in 2006-2009. The majority of trials (72.2% had no structured trial-article link present. A total of 2367 trials (26.6% deposited basic summary results within the registry. Of those, 969 trials (10.9% were classified as trials with extended results and 1398 trials (15.7% were classified as trials with only required basic results. The majority of the trials (54.8% had no evidence of results, based on either linked result articles or basic summary results (silent trials, while a minimal number (9.2% report results through both registry deposition and publication. DISCUSSION: Our study analyzes the body of linked knowledge around clinical trials (which we refer to as the "trialome". Our results show that most trials do not report results and, for those that do, there is minimal overlap in the types of reporting. We identify several mechanisms by which the linkages between trials and their published results can be increased. CONCLUSION: Our study shows that even when combining publications and registry results, and despite availability of several information channels, trial sponsors do not sufficiently meet the mandate to inform the public either via a linked result publication or basic results submission.

Clinical Trials

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Full Text Available ... to main content U.S. Department of Health & Human ... of people. Clinical trials produce the best data available for health care decisionmaking. The purpose of clinical trials is research, ...

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Full Text Available ... risks that outweigh any possible benefits. Clinical Trial Phases Clinical trials of new medicines or medical devices are done in phases. These phases have different purposes and help researchers ...

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Full Text Available ... well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. The NIH may partner with these companies or groups to help sponsor some trials. All ...

Can we identify non-stationary dynamics of trial-to-trial variability?

Directory of Open Access Journals (Sweden)

Emili Balaguer-Ballester

Full Text Available Identifying sources of the apparent variability in non-stationary scenarios is a fundamental problem in many biological data analysis settings. For instance, neurophysiological responses to the same task often vary from each repetition of the same experiment (trial to the next. The origin and functional role of this observed variability is one of the fundamental questions in neuroscience. The nature of such trial-to-trial dynamics however remains largely elusive to current data analysis approaches. A range of strategies have been proposed in modalities such as electro-encephalography but gaining a fundamental insight into latent sources of trial-to-trial variability in neural recordings is still a major challenge. In this paper, we present a proof-of-concept study to the analysis of trial-to-trial variability dynamics founded on non-autonomous dynamical systems. At this initial stage, we evaluate the capacity of a simple statistic based on the behaviour of trajectories in classification settings, the trajectory coherence, in order to identify trial-to-trial dynamics. First, we derive the conditions leading to observable changes in datasets generated by a compact dynamical system (the Duffing equation. This canonical system plays the role of a ubiquitous model of non-stationary supervised classification problems. Second, we estimate the coherence of class-trajectories in empirically reconstructed space of system states. We show how this analysis can discern variations attributable to non-autonomous deterministic processes from stochastic fluctuations. The analyses are benchmarked using simulated and two different real datasets which have been shown to exhibit attractor dynamics. As an illustrative example, we focused on the analysis of the rat's frontal cortex ensemble dynamics during a decision-making task. Results suggest that, in line with recent hypotheses, rather than internal noise, it is the deterministic trend which most likely underlies

Comparison of reporting phase I trial results in ClinicalTrials.gov and matched publications.

Science.gov (United States)

Shepshelovich, D; Goldvaser, H; Wang, L; Abdul Razak, A R; Bedard, P L

2017-12-01

Background Data on completeness of reporting of phase I cancer clinical trials in publications are lacking. Methods The ClinicalTrials.gov database was searched for completed adult phase I cancer trials with reported results. PubMed was searched for matching primary publications published prior to November 1, 2016. Reporting in primary publications was compared with the ClinicalTrials.gov database using a 28-point score (2=complete; 1=partial; 0=no reporting) for 14 items related to study design, outcome measures and safety profile. Inconsistencies between primary publications and ClinicalTrials.gov were recorded. Linear regression was used to identify factors associated with incomplete reporting. Results After a review of 583 trials in ClinicalTrials.gov , 163 matching primary publications were identified. Publications reported outcomes that did not appear in ClinicalTrials.gov in 25% of trials. Outcomes were upgraded, downgraded or omitted in publications in 47% of trials. The overall median reporting score was 23/28 (interquartile range 21-25). Incompletely reported items in >25% publications were: inclusion criteria (29%), primary outcome definition (26%), secondary outcome definitions (53%), adverse events (71%), serious adverse events (80%) and dates of study start and database lock (91%). Higher reporting scores were associated with phase I (vs phase I/II) trials (ppublication in journals with lower impact factor (p=0.004). Conclusions Reported results in primary publications for early phase cancer trials are frequently inconsistent or incomplete compared with ClinicalTrials.gov entries. ClinicalTrials.gov may provide more comprehensive data from new cancer drug trials.

Clinical Trials

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Full Text Available ... Some companies and groups sponsor clinical trials that test the safety of products, such as medicines, and how well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. ...

75 FR 49351 - Prevailing Rate Systems; Nonappropriated Fund Wage and Survey Areas

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2010-08-13

... Jersey: Atlantic Cape May Ocean Salem Monmouth Survey Area New Jersey: Monmouth Area of Application...: Alabama: Mobile Mississippi: Forest Jackson Lauderdale Survey Area Mississippi: Lauderdale Area of...

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Full Text Available ... trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective ... trials are research studies that explore whether a medical strategy, treatment, or device is safe and effective ...

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Full Text Available ... medical strategy, treatment, or device is safe and effective for humans. What Are Clinical Trials? Clinical trials ... medical strategy, treatment, or device is safe and effective for humans. These studies also may show which ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... include factors such as a patient's age and gender, the type and stage of disease, and whether ...

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Full Text Available ... needed. For safety purposes, clinical trials start with small groups of patients to find out whether a ... phase I clinical trials test new treatments in small groups of people for safety and side effects. ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... care providers might be part of your treatment team. They will monitor your health closely. You may ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute of Health ...

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Full Text Available ... comparison groups by chance, rather than choice. This method helps ensure that any differences observed during a ... to learn more about clinical research and to search for clinical trials: NHLBI Clinical Trials Browse a ...

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Full Text Available ... for trials with cutting-edge approaches, such as gene therapy or new biological treatments. Health insurance and ... trials that involve high-risk procedures (such as gene therapy) or vulnerable patients (such as children). A ...

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Full Text Available ... medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a key research tool for ... other for moderate persistent asthma. The results provided important treatment information for doctors and patients. The results ...

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Full Text Available ... clinical trials. An IRB is an independent committee created by the institution that sponsors a clinical trial. ... have not only shaped medical practice around the world, but have improved the health of millions of ...

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Full Text Available ... trials produce the best data available for health care decisionmaking. The purpose of clinical trials is research, ... they advance medical knowledge and help improve patient care. Sponsorship and Funding The National Heart, Lung, and ...

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Full Text Available ... these results are important because they advance medical knowledge and help improve patient care. Sponsorship and Funding ... All types of clinical trials contribute to medical knowledge and practice. Why Clinical Trials Are Important Clinical ...

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Full Text Available ... best data available for health care decisionmaking. The purpose of clinical trials is research, so the studies ... Thus, research in humans is needed. For safety purposes, clinical trials start with small groups of patients ...

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Full Text Available ... are research studies that explore whether a medical strategy, treatment, or device is safe and effective for ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... Customer Service/Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute ...

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Full Text Available ... the past, clinical trial participants often were White men. Researchers assumed that trial results were valid for ... different ethnic groups sometimes respond differently than White men to the same medical approach. As a result, ...

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Full Text Available ... whether a new approach causes any harm. In later phases of clinical trials, researchers learn more about ... other National Institutes of Health (NIH) Institutes and Centers sponsor clinical trials. Many other groups, companies, and ...

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Full Text Available ... healthy people to test new approaches to prevention, diagnosis, or screening. In the past, clinical trial participants ... DSMBs for large trials comparing alternative strategies for diagnosis or treatment. In addition, the NIH requires DSMBs ...

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Full Text Available ... at the smallest dose and for the shortest time possible. Clinical trials, like the two described above, ... in a clinical trial, find out ahead of time about costs and coverage. You should learn about ...

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Full Text Available ... Events About NHLBI About NHLBI Home Mission and Strategic Vision Leadership Scientific Divisions Operations and Administration Advisory ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ...

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Full Text Available ... decisionmaking. The purpose of clinical trials is research, so the studies follow strict scientific standards. These standards ... otherwise. The purpose of clinical trials is research, so the studies follow strict scientific standards. These standards ...

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Full Text Available ... sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include Government Agencies, ... and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers (including the NHLBI) usually ...

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Full Text Available ... or strategies work best for certain illnesses or groups of people. Some clinical trials show a positive result. For example, the National Heart, Lung, and Blood Institute (NHLBI) sponsored a trial of two different ...

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Full Text Available ... sponsored a trial of two different combinations of asthma treatments. The trial found that one of the ... much better than the other for moderate persistent asthma. The results provided important treatment information for doctors ...

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Full Text Available ... and doctors' offices around the country. Benefits and Risks Possible Benefits Taking part in a clinical trial ... volunteer because they want to help others. Possible Risks Clinical trials do have risks and some downsides, ...

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Full Text Available ... What to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might ... enroll in a clinical trial, a doctor or nurse will give you an informed consent form that ...

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Full Text Available ... medical knowledge and practice. Why Clinical Trials Are Important Clinical trials are a key research tool for ... and Usage No FEAR Act Grants and Funding Customer Service/Center for Health Information Email Alerts Jobs ...

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Full Text Available ... providers don't always cover all patient care costs for clinical trials. If you're thinking about ... clinical trial, find out ahead of time about costs and coverage. You should learn about the risks ...

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Full Text Available ... including the NHLBI) usually sponsor trials that test principles or strategies. For example, one NHLBI study explored ... risks. Other examples of clinical trials that test principles or strategies include studies that explore whether surgery ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... Learn More Connect With Us Contact Us Directly Policies Privacy Policy Freedom of Information Act (FOIA) Accessibility ...

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Full Text Available ... and treatments that work best. How Clinical Trials Work If you take part in a clinical trial, ... your doctor about all of your treatment options. Together, you can make the best choice for you. ...

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Full Text Available ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, ... Customer Service/Center for Health Information Email Alerts Jobs and Careers Site Index About NHLBI National Institute ...

7 CFR 301.92-2 - Restricted, regulated, and associated articles; lists of proven hosts and associated plant taxa.

Science.gov (United States)

2010-01-01

... virginiana Witch hazel *Heteromeles arbutifolia Toyon *Kalmia spp. Kalmia—includes all species, hybrids, and... tree Pittosporum undulatum Victorian box Prunus laurocerasus English laurel, cherry laurel Prunus...

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Full Text Available ... organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments of Defense and ... to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be ...

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Full Text Available ... Departments of Defense and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers (including ... our campus or trials NIH has sponsored at universities, medical centers, and hospitals. ClinicalTrials.gov View a ...

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Full Text Available ... groups, companies, and organizations also sponsor clinical trials. Examples include Government Agencies, such as the U.S. Departments ... sponsor trials that test principles or strategies. For example, one NHLBI study explored whether the benefits of ...

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Full Text Available ... treatment, or device is safe and effective for humans. What Are Clinical Trials? Clinical trials are research ... are required to have an IRB. Office for Human Research Protections The U.S. Department of Health and ...

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Full Text Available ... and Centers sponsor clinical trials. Many other groups, companies, and organizations also sponsor clinical trials. Examples include ... U.S. Departments of Defense and Veterans Affairs; private companies; universities; and nonprofit organizations. NIH Institutes and Centers ( ...

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Full Text Available ... trials show what doesn't work or may cause harm. For example, the NHLBI Women's Health Initiative tested whether hormone therapy (HT) reduced the risk of heart disease in postmenopausal women. (When the trial began, HT ...

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Full Text Available ... Clinical trials produce the best data available for health care decisionmaking. The purpose of clinical trials is research, ... and advance medical care. They also can help health care decisionmakers direct resources to the strategies and treatments ...

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Full Text Available ... for trials with cutting-edge approaches, such as gene therapy or new biological treatments. Health insurance and health ... trials that involve high-risk procedures (such as gene therapy) or vulnerable patients (such as children). A DSMB's ...

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Full Text Available ... Working at the NHLBI Contact and FAQs Accessible Search Form Search the NHLBI, use the drop down list to ... to learn more about clinical research and to search for clinical trials: NHLBI Clinical Trials Browse a ...

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Full Text Available ... identified earlier than they would be in general medical practice. This is because late-phase trials have large ... supporting clinical trials that have not only shaped medical practice around the world, but have improved the health ...

Regulatory stability of the national gas sector to attraction of investments: a juridical approach about the buyer creditory under the mode project finances; Estabilidade regulatoria do setor gaseifero nacional para atracao de investimentos: uma abordagem juridica acerca dos financiamentos sob a modalidade 'project finances'

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Albuquerque Junior, Helio Varela de [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Programa de Recursos Humanos PRH-36-ANP/MCT. Curso de Direito

2008-07-01

A stability of the Natural Gas regulation's framework assumes nowadays, for sure, a relevant position, once means a way of attracting new investments to the Oil and Gas Industry's sector. Following a logic sequence - regulation stability brings legal certainty witch reduces, on the other hand, the risks and attracts investment - the idea of a regulation's commitment on the natural gas sector sets as a key element for investment's attraction. Likewise, the financial agents position is extremely important, especially for the 'Project Finances' funding, witch inherent peculiarity (market risk's reduction) keep full compatibility with the needs of today's Brazilian natural gas sector framework. (author)

Estudio sobre dos plantas homéricas : mandrágora y moly

Directory of Open Access Journals (Sweden)

José Manuel Cuesta Pastor

2002-01-01

Full Text Available En la Odisea, la bruja Circe envenena a ios amigos de Odiseo, convirtiéndoles en cerdos. Mermes proporciona a éste el antídoto para poder rescatarlos. Con el apoyo de manuales botánicos y la mitología se tratará de demostrar la identidad del phármacon de la maga y su antídoto.In Odyssey, the witch Circe poisons Odysseu's friends, transforming them into pigs. Hermes provides the antidote wich saves them. With the support of the botanical consultants and the mythology we will try to demónstrate the identity of phármacon of the witch and the antidote.

Flight and abduction in witchcraft and UFO lore.

Science.gov (United States)

Musgrave, J B; Houran, J

2000-04-01

The lore surrounding the mythical Witches' Sabbat and contemporary reports of UFO abductions share three main characteristics: the use of masks, the appearance of "Men in Black," and references to flight and abduction. We review these three commonalities with particular focus on the aspect of flight and abduction. We argue that narratives of the Witches' Sabbat and UFO abductions share the same basic structure, common symbolism, and serve the same psychological needs of providing a coherent explanation for anomalous (ambiguous) experiences while simultaneously giving the experient a sense of freedom, release, and escape from the self. This pattern of similarities suggests the possibility that UFO abductions are a modern version of tales of flight to the Sabbat.

Clinical Trials

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Full Text Available ... the clinical trial you take part in, the information gathered can help others and add to scientific knowledge. People who take part in clinical trials are vital to the process of improving medical care. Many people volunteer because ...

Clinical Trials

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Full Text Available ... people who fit the patient traits for that study (the eligibility criteria). Eligibility criteria differ from trial to trial. They include factors such as a patient's age and gender, the type and stage of disease, and whether ...

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Full Text Available ... Sponsors also may stop a trial, or part of a trial, early if the strategy or treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight ...

Successful recruitment to trials: findings from the SCIMITAR+ Trial.

Science.gov (United States)

Peckham, Emily; Arundel, Catherine; Bailey, Della; Callen, Tracy; Cusack, Christina; Crosland, Suzanne; Foster, Penny; Herlihy, Hannah; Hope, James; Ker, Suzy; McCloud, Tayla; Romain-Hooper, Crystal-Bella; Stribling, Alison; Phiri, Peter; Tait, Ellen; Gilbody, Simon

2018-01-19

Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial of a bespoke smoking cessation intervention for people with severe mental ill health achieved their recruitment ahead of time and target. This article reports strategies that helped us to achieve this with the aim of aiding others recruiting from similar populations. SCIMITAR+ is a multi-centre pragmatic two-arm parallel-group RCT, which aimed to recruit 400 participants with severe mental ill health who smoke and would like to cut down or quit. The study recruited primarily in secondary care through community mental health teams and psychiatrists with a smaller number of participants recruited through primary care. Recruitment opened in October 2015 and closed in December 2016, by which point 526 participants had been recruited. We gathered information from recruiting sites on strategies which led to the successful recruitment in SCIMITAR+ and in this article present our approach to trial management along with the strategies employed by the recruiting sites. Alongside having a dedicated trial manager and trial management team, we identified three main themes that led to successful recruitment. These were: clinicians with a positive attitude to research; researchers and clinicians working together; and the use of NHS targets. The overriding theme was the importance of relationships between both the researchers and the recruiting clinicians and the recruiting clinicians and the participants. This study makes a significant contribution to the limited evidence base of real-world cases of successful recruitment to RCTs and offers practical guidance to those planning and conducting trials. Building positive relationships between clinicians, researchers and participants is crucial to successful recruitment.

UK Dermatology Clinical Trials Network's STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial.

Science.gov (United States)

Craig, Fiona F; Thomas, Kim S; Mitchell, Eleanor J; Williams, Hywel C; Norrie, John; Mason, James M; Ormerod, Anthony D

2012-04-28

Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means that there is a lack of published evidence regarding its treatment. A systematic review published in 2005 found no randomised controlled trials (RCTs) relating to the treatment of PG. Since this time, one small RCT has been published comparing infliximab to placebo, but none of the commonly used systemic treatments for PG have been formally assessed. The UK Dermatology Clinical Trials Network's STOP GAP Trial has been designed to address this lack of trial evidence. The objective is to assess whether oral ciclosporin is more effective than oral prednisolone for the treatment of PG. The trial design is a two-arm, observer-blind, parallel-group, randomised controlled trial comparing ciclosporin (4 mg/kg/day) to prednisolone (0.75 mg/kg/day). A total of 140 participants are to be recruited over a period of 4 years, from up to 50 hospitals in the UK and Eire. Primary outcome of velocity of healing at 6 weeks is assessed blinded to treatment allocation (using digital images of the ulcers). Secondary outcomes include: (i) time to healing; (ii) global assessment of improvement; (iii) PG inflammation assessment scale score; (iv) self-reported pain; (v) health-related quality of life; (vi) time to recurrence; (vii) treatment failures; (viii) adverse reactions to study medications; and (ix) cost effectiveness/utility. Patients with a clinical diagnosis of PG (excluding granulomatous PG); measurable ulceration (that is, not pustular PG); and patients aged over 18 years old who are able to give informed consent are included in the trial. Randomisation is by computer generated code using permuted blocks of randomly varying size, stratified by lesion size, and

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Full Text Available ... other expenses (for example, travel and child care)? Who will be in charge of my care? What will happen after the trial? Taking part in a clinical trial is your decision. Talk with your doctor about all of your treatment ...

Interpreting clinical trial results by deductive reasoning: In search of improved trial design.

Science.gov (United States)

Kurbel, Sven; Mihaljević, Slobodan

2017-10-01

Clinical trial results are often interpreted by inductive reasoning, in a trial design-limited manner, directed toward modifications of the current clinical practice. Deductive reasoning is an alternative in which results of relevant trials are combined in indisputable premises that lead to a conclusion easily testable in future trials. © 2017 WILEY Periodicals, Inc.

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Full Text Available ... Medical Center, Winston-Salem, NC, 1/15/2009) Pituitary Tumors Transnasal Endoscopic ... Surgical Removal of the Thyroid Gland (Baptist Health South Florida, Miami, FL, 2/01/ ...

Fundamentals of clinical trials

CERN Document Server

Friedman, Lawrence M; DeMets, David L; Reboussin, David M; Granger, Christopher B

2015-01-01

This is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise.  Most chapters have been revised considerably from the fourth edition.  A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded.  Many contemporary clinical trial examples have been added.  There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing, and international trials.  This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of ...

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum: protocol for a randomised controlled trial

Directory of Open Access Journals (Sweden)

Craig Fiona F

2012-04-01

Full Text Available Abstract Background Pyoderma gangrenosum (PG is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means that there is a lack of published evidence regarding its treatment. A systematic review published in 2005 found no randomised controlled trials (RCTs relating to the treatment of PG. Since this time, one small RCT has been published comparing infliximab to placebo, but none of the commonly used systemic treatments for PG have been formally assessed. The UK Dermatology Clinical Trials Network’s STOP GAP Trial has been designed to address this lack of trial evidence. Methods The objective is to assess whether oral ciclosporin is more effective than oral prednisolone for the treatment of PG. The trial design is a two-arm, observer-blind, parallel-group, randomised controlled trial comparing ciclosporin (4 mg/kg/day to prednisolone (0.75 mg/kg/day. A total of 140 participants are to be recruited over a period of 4 years, from up to 50 hospitals in the UK and Eire. Primary outcome of velocity of healing at 6 weeks is assessed blinded to treatment allocation (using digital images of the ulcers. Secondary outcomes include: (i time to healing; (ii global assessment of improvement; (iii PG inflammation assessment scale score; (iv self-reported pain; (v health-related quality of life; (vi time to recurrence; (vii treatment failures; (viii adverse reactions to study medications; and (ix cost effectiveness/utility. Patients with a clinical diagnosis of PG (excluding granulomatous PG; measurable ulceration (that is, not pustular PG; and patients aged over 18 years old who are able to give informed consent are included in the trial. Randomisation is by computer generated code using permuted blocks of randomly varying size

Clinical Trials

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Full Text Available ... a Clinical Trial If you're interested in learning more about, or taking part in, clinical trials, talk with your doctor. He or she may know about studies going on in your area. You can visit the following website to learn more about ...

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Full Text Available ... Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be part of your treatment ... phase II clinical trials. The risk of side effects might be even greater for ... treatments. Health insurance and health care providers don't always ...

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Full Text Available ... benefits of lowering high blood pressure in the elderly outweighed the risks. Other examples of clinical trials ... child to enroll. Also, children aged 7 and older often must agree (assent) to ... as clinical trials for adults. For more information, go to "How Do Clinical ...

Reinventing clinical trials: a review of innovative biomarker trial designs in cancer therapies.

Science.gov (United States)

Lin, Ja-An; He, Pei

2015-06-01

Recently, new clinical trial designs involving biomarkers have been studied and proposed in cancer clinical research, in the hope of incorporating the rapid growing basic research into clinical practices. Journal articles related to various biomarkers and their role in cancer clinical trial, articles and books about statistical issues in trial design, and regulatory website, documents, and guidance for submission of targeted cancer therapies. The drug development process involves four phases. The confirmatory Phase III is essential in regulatory approval of a special treatment. Regulatory agency has restrictions on confirmatory trials 'using adaptive designs'. No rule of thumb to pick the most appropriate design for biomarker-related trials. Statistical issues to solve in new designs. Regulatory acceptance of the 'newly proposed trial designs'. Biomarker-related trial designs that can resolve the statistical issues and satisfy the regulatory requirement. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Witches howl on New Year's Eve

DEFF Research Database (Denmark)

Grünbaum, Liselotte

1997-01-01

on the setting has to be picked up and contained both in the therapeutic relationship and in the network by teamwork, and b) by carefully following the child's movements in the transference relationship, the child can be helped to a dependent relationship inside which feelings can be made sense of....

Computer controls for the WITCH experiment

Czech Academy of Sciences Publication Activity Database

Tandecki, M.; Beck, M.; Beck, D.; Brand, H.; Breitenfeldt, M.; De Leebeeck, V.; Friedag, P.; Herlert, A.; Kozlov, V.; Mader, J.; Roccia, S.; Soti, G.; Traykov, E.; Van Gorp, S.; Wauters, F.; Weinheimer, C.; Zákoucký, Dalibor; Severijns, N.

2011-01-01

Roč. 629, č. 1 (2011), s. 369-405 ISSN 0168-9002 R&D Projects: GA MŠk LA08015 Institutional research plan: CEZ:AV0Z10480505; CEZ:AV0Z10100523 Keywords : LabVIEW * Control system * Distributed programming Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 1.207, year: 2011

78 FR 13378 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Science.gov (United States)

2013-02-27

... Monastery, 5700 N. Harlem Dr., Chicago, 13000048 Storkline Furniture Corporation Factory, 4400-4418 W. 26th St., Chicago, 13000049 MASSACHUSETTS Essex County North Street Fire Station, 142 North St., Salem...

78 FR 42975 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

Science.gov (United States)

2013-07-18

..., Dietikon, SWITZERLAND; Koyo Electronics Industries Co., Ltd.; Tokyo, JAPAN; vMonitor, LLC, Abu Dhabi... to this venture. Also, Office FA.com Co., Ltd., Tochigi, JAPAN; and Salem Automation Inc., Winston...

Ao38, a new cell line from eggs of the black witch moth, Ascalapha odorata (Lepidoptera: Noctuidae, is permissive for AcMNPV infection and produces high levels of recombinant proteins

Directory of Open Access Journals (Sweden)

Zhang Sheng

2010-07-01

Full Text Available Abstract Background The insect cell line is a critical component in the production of recombinant proteins in the baculovirus expression system and new cell lines hold the promise of increasing both quantity and quality of protein production. Results Seventy cell lines were established by single-cell cloning from a primary culture of cells derived from eggs of the black witch moth (Ascalapha odorata; Lepidoptera, Noctuidae. Among 8 rapidly growing lines, cell line 38 (Ao38 was selected for further analysis, based on susceptibility to AcMNPV infection and production of secreted alkaline phosphatase (SEAP from a baculovirus expression vector. In comparisons with low-passage High Five (BTI-Tn-5B1-4 cells, infected Ao38 cells produced β-galactosidase and SEAP at levels higher (153% and 150%, respectively than those measured from High Five cells. Analysis of N-glycans of SEAP produced in Ao38 cells revealed two N-glycosylation sites and glycosylation patterns similar to those reported for High Five and Sf9 cells. Glycopeptide isoforms consisted of pauci- or oligomannose, with and without fucose on N-acetylglucosamine(s linked to asparagine residues. Estimates of Ao38 cell volume suggest that Ao38 cells are approximately 2.5× larger than Sf9 cells but only approximately 74% of the size of High Five cells. Ao38 cells were highly susceptible to AcMNPV infection, similar to infectivity of Sf9 cells. Production of infectious AcMNPV budded virions from Ao38 cells peaked at approximately 4.5 × 107 IU/ml, exceeding that from High Five cells while lower than that from Sf9 cells. Ao38 cells grew rapidly in stationary culture with a population doubling time of 20.2 hr, and Ao38 cells were readily adapted to serum-free medium (Sf-900III and to a suspension culture system. Analysis of Ao38 and a parental Ascalapha odorata cell line indicated that these lines were free of the alphanodavirus that was recently identified as an adventitious agent in High Five cell

Clinical Trials

Medline Plus

Full Text Available ... trial found that one of the combinations worked much better than the other for moderate persistent asthma. The results provided important treatment information for doctors and patients. The results from other clinical trials show what doesn't work or may cause harm. For example, the NHLBI ...

Clinical Trials

Medline Plus

Full Text Available ... products, such as medicines, and how well they work. The U.S. Food and Drug Administration (FDA) oversees these clinical trials. ... cancer also increased. As a result, the U.S. Food and Drug Administration now recommends never using HT ... Clinical Trials Work If you take ...

OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of rehabilitation interventions for osteoarthritis.

Science.gov (United States)

Fitzgerald, G K; Hinman, R S; Zeni, J; Risberg, M A; Snyder-Mackler, L; Bennell, K L

2015-05-01

A Task Force of the Osteoarthritis Research Society International (OARSI) has previously published a set of guidelines for the conduct of clinical trials in osteoarthritis (OA) of the hip and knee. Limited material available on clinical trials of rehabilitation in people with OA has prompted OARSI to establish a separate Task Force to elaborate guidelines encompassing special issues relating to rehabilitation of OA. The Task Force identified three main categories of rehabilitation clinical trials. The categories included non-operative rehabilitation trials, post-operative rehabilitation trials, and trials examining the effectiveness of devices (e.g., assistive devices, bracing, physical agents, electrical stimulation, etc.) that are used in rehabilitation of people with OA. In addition, the Task Force identified two main categories of outcomes in rehabilitation clinical trials, which include outcomes related to symptoms and function, and outcomes related to disease modification. The guidelines for rehabilitation clinical trials provided in this report encompass these main categories. The report provides guidelines for conducting and reporting on randomized clinical trials. The topics include considerations for entering patients into trials, issues related to conducting trials, considerations for selecting outcome measures, and recommendations for statistical analyses and reporting of results. The focus of the report is on rehabilitation trials for hip, knee and hand OA, however, we believe the content is broad enough that it could be applied to rehabilitation trials for other regions as well. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

New water guidelines developed to battle nuclear corrosion

International Nuclear Information System (INIS)

Strauss, S.D.

1983-01-01

Discusses methods of preventing degradation of nuclear steam generators due to a combination of impurities and corrosion products in the secondary system. Explains that tube and support-plate corrosion has been the main concern, manifesting itself primarily in the recirculating units used in PWR systems. Points out that the battle against corrosion is closely linked to control of ionic impurities, alkalinity, oxidants, and sludge-copper and iron corrosion products, primarily-in condensate and feedwater systems. Examines a set of secondary-water-chemistry guidelines developed by the Steam Generator Owners Group (SGOG). Presents diagram showing changes at Salem 1 to arrest corrosion, including condenser retubing, addition of condensate polisher and recirculation loop. Table indicates how preventive measures at Salem 1, affected secondary-water chemistry

77 FR 51521 - New England Fishery Management Council; Public Meeting

Science.gov (United States)

2012-08-24

..., Georges Bank yellowtail flounder, witch flounder, plaice, and Georges Bank/Gulf of Maine white hake... meeting is physically accessible to people with disabilities. Requests for sign language interpretation or...

Clinical Trials

Medline Plus

Full Text Available ... from other clinical trials show what doesn't work or may cause harm. For example, the NHLBI Women's Health Initiative ... safe a treatment is or how well it works. Children (aged 18 and younger) get ... legal consent for their child to take part in a clinical trial. When ...

Clinical Trials

Medline Plus

Full Text Available ... to Expect During a clinical trial, doctors, nurses, social workers, and other health care providers might be part of your treatment ... clinical trials are vital to the process of improving medical care. Many people ... participants, it may not work for you. A new treatment may have side ...

[Clinical trials in nursing journals].

Science.gov (United States)

Di Giulio, Paola; Campagna, Sara; Dimonte, Valerio

2014-01-01

Clinical trials are pivotal for the development of nursing knowledge. To describe the clinical trials published in nursing journals in the last two years and propose some general reflections on nursing research. A search with the key-word trial was done on PubMed (2009-2013) on Cancer Nursing, European Journal of Oncology Nursing, International Journal of Nursing Studies, Journal of Advanced Nursing, Journal of Clinical Nursing and Nursing Research. Of 228 trials identified, 104 (45.8%) were published in the last 2 years. Nurses from Asian countries published the larger number of trials. Educational and supportive interventions were the most studied (61/104 trials), followed by clinical interventions (33/104). Samples were limited and most trials are monocentric. A growing number of trials is published, on issues relevant for the nursing profession, however larger samples and multicentric studies would be necessary.

Clinical utility of fixed-dose combinations in hypertension: evidence for the potential of nebivolol/valsartan

Directory of Open Access Journals (Sweden)

Varagic J

2014-11-01

Full Text Available Jasmina Varagic,1–3 Henry Punzi,4,5 Carlos M Ferrario2,3,61Hypertension and Vascular Research Center, 2Division of Surgical Sciences, 3Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC USA; 4Trinity Hypertension and Diagnostic Research Center, Carrollton, TX, USA; 5Department of Family and Community Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA; 6Department of Internal Medicine and Nephrology, Wake Forest University, Winston-Salem, NC, USAAbstract: Despite significant advances in pharmacologic approaches to treat hypertension during the last decades, hypertension- and hypertension-related organ damage are still a high health and economic burden because a large proportion of patients with hypertension do not achieve optimal blood pressure control. There is now general agreement that combination therapy with two or more antihypertensive drugs is required for targeted blood pressure accomplishment and reduction of global cardiovascular risk. The goals of combination therapies are to reduce long-term cardiovascular events by targeting different mechanism underlying hypertension and target organ disease, to block the counterregulatory pathways activated by monotherapies, to improve tolerability and decrease the adverse effects of up-titrated single agents, and to increase persistence and adherence with antihypertensive therapy. Multiple clinical trials provide evidence that fixed-dose combinations in a single pill offer several advantages when compared with loose-dose combinations. This review discusses the advances in hypertension control and associated cardiovascular disease as they relate to the prospect of combination therapy targeting a third-generation beta (β 1-adrenergic receptor (nebivolol and an angiotensin II receptor blocker (valsartan in fixed-dose single-pill formulations.Keywords: blood pressure control, hypertension, β1-adrenergic receptor, renin angiotensin system

Clinical Trials in Dentistry: A Cross-sectional Analysis of World Health Organization-International Clinical Trial Registry Platform.

Science.gov (United States)

Sivaramakrishnan, Gowri; Sridharan, Kannan

2016-06-01

Clinical trials are the back bone for evidence-based practice (EBP) and recently EBP has been considered the best source of treatment strategies available. Clinical trial registries serve as databases of clinical trials. As regards to dentistry in specific data on the number of clinical trials and their quality is lacking. Hence, the present study was envisaged. Clinical trials registered in WHO-ICTRP (http://apps.who.int/trialsearch/AdvSearch.aspx) in dental specialties were considered. The details assessed from the collected trials include: Type of sponsors; Health condition; Recruitment status; Study design; randomization, method of randomization and allocation concealment; Single or multi-centric; Retrospective or prospective registration; and Publication status in case of completed studies. A total of 197 trials were identified. Maximum trials were from United States (n = 30) and United Kingdom (n = 38). Seventy six trials were registered in Clinical Trials.gov, 54 from International Standards of Reporting Clinical Trials, 13 each from Australia and New Zealand Trial Register and Iranian Registry of Clinical Trials, 10 from German Clinical Trial Registry, eight each from Brazilian Clinical Trial Registry and Nederland's Trial Register, seven from Japan Clinical Trial Registry, six from Clinical Trial Registry of India and two from Hong Kong Clinical Trial Registry. A total of 78.7% studies were investigator-initiated and 64% were completed while 3% were terminated. Nearly four-fifths of the registered trials (81.7%) were interventional studies of which randomized were the large majority (94.4%) with 63.2% being open label, 20.4% using single blinding technique and 16.4% were doubled blinded. The number, methodology and the characteristics of clinical trials in dentistry have been noted to be poor especially in terms of being conducted multi-centrically, employing blinding and the method for randomization and allocation concealment. More emphasis has to be

Clinical trial methodology

National Research Council Canada - National Science Library

Peace, Karl E; Chen, Ding-Geng

2011-01-01

"Now viewed as its own scientific discipline, clinical trial methodology encompasses the methods required for the protection of participants in a clinical trial and the methods necessary to provide...

Trial-to-Trial Carryover in Auditory Short-Term Memory

Science.gov (United States)

Visscher, Kristina M.; Kahana, Michael J.; Sekuler, Robert

2009-01-01

Using a short-term recognition memory task, the authors evaluated the carryover across trials of 2 types of auditory information: the characteristics of individual study sounds (item information) and the relationships between the study sounds (study set homogeneity). On each trial, subjects heard 2 successive broadband study sounds and then…

An Interview with Stephen King.

Science.gov (United States)

Janeczko, Paul

1980-01-01

The author of five best-selling novels, including "Carrie,""Salem's Lot,""The Shining,""The Stand," and "The Dead Zone," discusses the teaching of creative writing at high school and college levels. (DF)

Are multiple-trial experiments appropriate for eyewitness identification studies? Accuracy, choosing, and confidence across trials.

Science.gov (United States)

Mansour, J K; Beaudry, J L; Lindsay, R C L

2017-12-01

Eyewitness identification experiments typically involve a single trial: A participant views an event and subsequently makes a lineup decision. As compared to this single-trial paradigm, multiple-trial designs are more efficient, but significantly reduce ecological validity and may affect the strategies that participants use to make lineup decisions. We examined the effects of a number of forensically relevant variables (i.e., memory strength, type of disguise, degree of disguise, and lineup type) on eyewitness accuracy, choosing, and confidence across 12 target-present and 12 target-absent lineup trials (N = 349; 8,376 lineup decisions). The rates of correct rejections and choosing (across both target-present and target-absent lineups) did not vary across the 24 trials, as reflected by main effects or interactions with trial number. Trial number had a significant but trivial quadratic effect on correct identifications (OR = 0.99) and interacted significantly, but again trivially, with disguise type (OR = 1.00). Trial number did not significantly influence participants' confidence in correct identifications, confidence in correct rejections, or confidence in target-absent selections. Thus, multiple-trial designs appear to have minimal effects on eyewitness accuracy, choosing, and confidence. Researchers should thus consider using multiple-trial designs for conducting eyewitness identification experiments.

Update on TROG trials

International Nuclear Information System (INIS)

Joseph, D.

2001-01-01

Full text: Validation of treatment methodologies can only be achieved in the context of unambiguous, efficiently managed, randomised and controlled clinical trials. Since 1991, the Trans-Tasman Radiation Oncology Group (TROG) has coordinated over 29 protocols in radiation oncology, including several key randomised controlled trials. The impetus behind TROG is the establishment of an evidence base for particular approaches to radiotherapy and its adjunct use with alternative and complementary treatment methods. As the level of technology incorporated into radiotherapy continues to increase, as the need for improved accuracy in dose assessment increases and as the requirements of realistic quality assurance (QA) for clinical trials becomes more demanding it is imperative that all professionals involved in radiotherapy, including physicists, become actively involved in the QA of trials. This is particularly important for large scale multi-centre trials which intend to prove the benefits of particular treatment approaches on a national or international stage rather then in the context of a single clinic. This talk will: 1. Examine the outcomes of TROG trials to date in terms of the information obtained. 2. Briefly consider current and impending TROG trials and their requirements in terms of clinical and physics input. 3. Examine the results of international clinical trials in terms of the influence they have had on radiotherapy practice and health outcomes, and the advantages they have obtained by consistent co-operation between clinical and technological staff. 4. Consider the benefits of multi-centre clinical trials and the QA controls that are necessary to ensure accuracy of resulting recommendations. Copyright (2001) Australasian College of Physical Scientists and Engineers in Medicine

Studies on cytotoxicity and antitumor screening of red and white ...

African Journals Online (AJOL)

STORAGESEVER

2008-11-19

Nov 19, 2008 ... 2Department of Botany, Government Arts College (Autonomous), Salem – 636 007, Tamilnadu, India. ... namely red and black coloured seeds (red form) and the ... development induced by Dalton's Lymphoma Ascites.

Reward-prospect interacts with trial-by-trial preparation for potential distraction.

Science.gov (United States)

Marini, Francesco; van den Berg, Berry; Woldorff, Marty G

2015-02-01

When attending for impending visual stimuli, cognitive systems prepare to identify relevant information while ignoring irrelevant, potentially distracting input. Recent work (Marini et al., 2013) showed that a supramodal distracter-filtering mechanism is invoked in blocked designs involving expectation of possible distracter stimuli, although this entails a cost ( distraction-filtering cost ) on speeded performance when distracters are expected but not presented. Here we used an arrow-flanker task to study whether an analogous cost, potentially reflecting the recruitment of a specific distraction-filtering mechanism, occurs dynamically when potential distraction is cued trial-to-trial ( cued distracter-expectation cost ). In order to promote the maximal utilization of cue information by participants, in some experimental conditions the cue also signaled the possibility of earning a monetary reward for fast and accurate performance. This design also allowed us to investigate the interplay between anticipation for distracters and anticipation of reward, which is known to engender attentional preparation. Only in reward contexts did participants show a cued distracter-expectation cost, which was larger with higher reward prospect and when anticipation for both distracters and reward were manipulated trial-to-trial. Thus, these results indicate that reward prospect interacts with the distracter expectation during trial-by-trial preparatory processes for potential distraction. These findings highlight how reward guides cue-driven attentional preparation.

Science and Shakespeare.

Science.gov (United States)

Mah, Steven; Chinnery, Charlene

2003-01-01

Describes an assignment in which the preservice teacher must find a connection between science and Shakespeare. Connects the science of the witches in Shakespeare's "Macbeth" to the holistic approach of education. (SG)

Biological evolution: Some genetic considerations | Salem ...

African Journals Online (AJOL)

Conclusion: Natural selection might be observed in nature but not in life. The concept of biological evolution is an illogic and insensible hypothesis since it stands in direct contradiction with our current knowledge regarding the behavior as well as the structural and functional characteristics of the human genome and human ...

Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials.

Directory of Open Access Journals (Sweden)

Paul P Christopher

Full Text Available Participants in clinical trials frequently fail to appreciate key differences between research and clinical care. This phenomenon, known as therapeutic misconception, undermines informed consent to clinical research, but to date there have been no effective interventions to reduce it and concerns have been expressed that to do so might impede recruitment. We determined whether a scientific reframing intervention reduces therapeutic misconception without significantly reducing willingness to participate in hypothetical clinical trials.This prospective randomized trial was conducted from 2015 to 2016 to test the efficacy of an informed consent intervention based on scientific reframing compared to a traditional informed consent procedure (control in reducing therapeutic misconception among patients considering enrollment in hypothetical clinical trials modeled on real-world studies for one of five disease categories. Patients with diabetes mellitus, hypertension, coronary artery disease, head/neck cancer, breast cancer, and major depression were recruited from medical clinics and a clinical research volunteer database. The primary outcomes were therapeutic misconception, as measured by a validated, ten-item Therapeutic Misconception Scale (range = 10-50, and willingness to participate in the clinical trial.154 participants completed the study (age range, 23-87 years; 92.3% white, 56.5% female; 74 (48.1% had been randomized to receive the experimental intervention. Therapeutic misconception was significantly lower (p = 0.004 in the scientific reframing group (26.4, 95% CI [23.7 to 29.1] compared to the control group (30.9, 95% CI [28.4 to 33.5], and remained so after controlling for education (p = 0.017. Willingness to participate in the hypothetical trial was not significantly different (p = 0.603 between intervention (52.1%, 95% CI [40.2% to 62.4%] and control (56.3%, 95% CI [45.3% to 66.6%] groups.An enhanced educational intervention augmenting

The clinically-integrated randomized trial: proposed novel method for conducting large trials at low cost

Directory of Open Access Journals (Sweden)

Scardino Peter T

2009-03-01

Full Text Available Abstract Introduction Randomized controlled trials provide the best method of determining which of two comparable treatments is preferable. Unfortunately, contemporary randomized trials have become increasingly expensive, complex and burdened by regulation, so much so that many trials are of doubtful feasibility. Discussion Here we present a proposal for a novel, streamlined approach to randomized trials: the "clinically-integrated randomized trial". The key aspect of our methodology is that the clinical experience of the patient and doctor is virtually indistinguishable whether or not the patient is randomized, primarily because outcome data are obtained from routine clinical data, or from short, web-based questionnaires. Integration of a randomized trial into routine clinical practice also implies that there should be an attempt to randomize every patient, a corollary of which is that eligibility criteria are minimized. The similar clinical experience of patients on- and off-study also entails that the marginal cost of putting an additional patient on trial is negligible. We propose examples of how the clinically-integrated randomized trial might be applied in four distinct areas of medicine: comparisons of surgical techniques, "me too" drugs, rare diseases and lifestyle interventions. Barriers to implementing clinically-integrated randomized trials are discussed. Conclusion The proposed clinically-integrated randomized trial may allow us to enlarge dramatically the number of clinical questions that can be addressed by randomization.

Clinical trials recruitment planning: A proposed framework from the Clinical Trials Transformation Initiative.

Science.gov (United States)

Huang, Grant D; Bull, Jonca; Johnston McKee, Kelly; Mahon, Elizabeth; Harper, Beth; Roberts, Jamie N

2018-03-01

Patient recruitment is widely recognized as a key determinant of success for clinical trials. Yet a substantial number of trials fail to reach recruitment goals-a situation that has important scientific, financial, ethical, and policy implications. Further, there are important effects on stakeholders who directly contribute to the trial including investigators, sponsors, and study participants. Despite efforts over multiple decades to identify and address barriers, recruitment challenges persist. To advance a more comprehensive approach to trial recruitment, the Clinical Trials Transformation Initiative (CTTI) convened a project team to examine the challenges and to issue actionable, evidence-based recommendations for improving recruitment planning that extend beyond common study-specific strategies. We describe our multi-stakeholder effort to develop a framework that delineates three areas essential to strategic recruitment planning efforts: (1) trial design and protocol development, (2) trial feasibility and site selection, and (3) communication. Our recommendations propose an upstream approach to recruitment planning that has the potential to produce greater impact and reduce downstream barriers. Additionally, we offer tools to help facilitate adoption of the recommendations. We hope that our framework and recommendations will serve as a guide for initial efforts in clinical trial recruitment planning irrespective of disease or intervention focus, provide a common basis for discussions in this area and generate targets for further analysis and continual improvement. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

77 FR 65365 - Procurement List; Additions

Science.gov (United States)

2012-10-26

..., TX Eyewear NSN: 6650-00-NIB-0009--Single Vision, Plastic, Clear NSN: 6650-00-NIB-0010--Flat Top 28... Administration, Department of Veterans Affairs, Pittsburgh PA. NPA: Winston-Salem Industries for the Blind, Inc...

A review on the solution of Grad–Shafranov equation in the ...

Indian Academy of Sciences (India)

2017-02-10

Feb 10, 2017 ... coordinates based on the Chebyshev collocation technique. Z AMERIAN, M K SALEM, ... the power supply system. Any contact with ... often needed. Numerical .... Using composite differentiation (chain rule), and con- sidering ...

Empowering Minority Communities with Health Information - WSSU

Energy Technology Data Exchange (ETDEWEB)

McMurray, L. and W. Templin-Branner

2010-11-10

Environmental health focus with training conducted as part of the United Negro College Fund Special Programs Corporation/National Library of Medicine HBCU ACCESS Project at Winston-Salem State University, NC on November 10, 2010.

Phenotypic and molecular genetic analysis of Pyruvate Kinase ...

African Journals Online (AJOL)

Phenotypic and molecular genetic analysis of Pyruvate Kinase deficiency in a Tunisian family. Jaouani Mouna, Hamdi Nadia, Chaouch Leila, Kalai Miniar, Mellouli Fethi, Darragi Imen, Boudriga Imen, Chaouachi Dorra, Bejaoui Mohamed, Abbes Salem ...

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database.

Science.gov (United States)

Cihoric, Nikola; Tsikkinis, Alexandros; Miguelez, Cristina Gutierrez; Strnad, Vratislav; Soldatovic, Ivan; Ghadjar, Pirus; Jeremic, Branislav; Dal Pra, Alan; Aebersold, Daniel M; Lössl, Kristina

2016-03-22

To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures. The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database. In total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p < 0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %). Most clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future.

New England electric utility takes the lead

Energy Technology Data Exchange (ETDEWEB)

New England Electric System has taken several steps to reduce dependence on foreign oil, save its customers money, and encourage the development of energy resources tailored to meet the region's energy needs. The heart of the plan is a stated objective of reducing annual peaking demand for electrical growth from a projected 3.1% to 1.9%. Other activities initiated are: a solar hot water demonstration project; the NEPCO's burning of a mixture of pulverized coal and residual fuel oil in one of its boilers at Salem Harbor Station in Salem, Massachusetts; purchasing and trading electricity with industrial and private small power producers; and participating in an effort to develop a plan to convert the Brayton Point power plant in Somerset, Massachusetts from oil to coal.

Au ban de la société, à la frontière de l’Amérique : les sorcières et les marginaux dans Moi, Tituba sorcière… de Maryse Condé

Directory of Open Access Journals (Sweden)

Maryse Sullivan

2017-05-01

Full Text Available Dans cet article, nous étudions la figure de la sorcière dans Moi, Tituba sorcière… de Maryse Condé afin de voir comment elle dialogue avec les discours postcoloniaux et féministes de l’époque. Nous analysons d’abord l’intertextualité construit dans le roman avec la pièce d’Arthur Miller Les sorcières de Salem en regardant comment Condé transforme les événements qui ont eu lieu à Salem en 1692 et comment elle réhabilite le personnage de Tituba. Nous nous penchons ensuite sur la figure de la sorcière et des marginaux dans le texte en vue de comprendre sa construction protéiforme et ses points de contact avec les discours ambiants.

Eto otshen strashno! / Irina Ivanova

Index Scriptorium Estoniae

Ivanova, Irina

2005-01-01

Walden Media tootis koos Walt Disney Pictures'iga ekraniseeringu C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" (Chronicles of Narnia : The Lion, the Witch and the Wardrobe")

Narnia lood pakuvad naudingut just lastele / Mari Rebane

Index Scriptorium Estoniae

Rebane, Mari

2005-01-01

Walden Media tootis koos Walt Disney Pictures'iga ekraniseeringu C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" (Chronicles of Narnia : The Lion, the Witch and the Wardrobe")

Popmuusika / Mart Juur

Index Scriptorium Estoniae

Juur, Mart, 1964-

2005-01-01

Uutest heliplaatidest John Lennon "Working Class Hero", Tito Puente y Su Orchestra "Viva Mambo", Sigur Ros "Takk", Ladytron "Witching Hour", Black Rebel Motorcycle Club "Howl", Ans. Andur "Tuled peale", Emmilou Harris "Heartaches & Highways"

Methodology Series Module 4: Clinical Trials.

Science.gov (United States)

Setia, Maninder Singh

2016-01-01

In a clinical trial, study participants are (usually) divided into two groups. One group is then given the intervention and the other group is not given the intervention (or may be given some existing standard of care). We compare the outcomes in these groups and assess the role of intervention. Some of the trial designs are (1) parallel study design, (2) cross-over design, (3) factorial design, and (4) withdrawal group design. The trials can also be classified according to the stage of the trial (Phase I, II, III, and IV) or the nature of the trial (efficacy vs. effectiveness trials, superiority vs. equivalence trials). Randomization is one of the procedures by which we allocate different interventions to the groups. It ensures that all the included participants have a specified probability of being allocated to either of the groups in the intervention study. If participants and the investigator know about the allocation of the intervention, then it is called an "open trial." However, many of the trials are not open - they are blinded. Blinding is useful to minimize bias in clinical trials. The researcher should familiarize themselves with the CONSORT statement and the appropriate Clinical Trials Registry of India.

Social media in clinical trials.

Science.gov (United States)

Thompson, Michael A

2014-01-01

Social media has potential in clinical trials for pointing out trial issues, addressing barriers, educating, and engaging multiple groups involved in cancer clinical research. Social media is being used in clinical trials to highlight issues such as poor accrual and barriers; educate potential participants and physicians about clinical trial options; and is a potential indirect or direct method to improve accrual. We are moving from a passive "push" of information to patients to a "pull" of patients requesting information. Patients and advocates are often driving an otherwise reluctant health care system into communication. Online patient communities are creating new information repositories. Potential clinical trial participants are using the Twittersphere and other sources to learn about potential clinical trial options. We are seeing more organized patient-centric and patient-engaged forums with the potential to crowd source to improve clinical trial accrual and design. This is an evolving process that will meet many individual, institutional, and regulatory obstacles as we move forward in a changed research landscape.

An analysis of registered clinical trials in otolaryngology from 2007 to 2010: ClinicalTrials.gov.

Science.gov (United States)

Witsell, David L; Schulz, Kristine A; Lee, Walter T; Chiswell, Karen

2013-11-01

To describe the conditions studied, interventions used, study characteristics, and funding sources of otolaryngology clinical trials from the ClinicalTrials.gov database; compare this otolaryngology cohort of interventional studies to clinical visits in a health care system; and assess agreement between clinical trials and clinical activity. Database analysis. Trial registration data downloaded from ClinicalTrials.gov and administrative data from the Duke University Medical Center from October 1, 2007 to September 27, 2010. Data extraction from ClinicalTrials.gov was done using MeSH and non-MeSH disease condition terms. Studies were subcategorized to create the following groupings for descriptive analysis: ear, nose, allergy, voice, sleep, head and neck cancer, thyroid, and throat. Duke Health System visits were queried by using selected ICD-9 codes for otolaryngology and non-otolaryngology providers. Visits were grouped similarly to ClinicalTrials.gov for further analysis. Chi-square tests were used to explore differences between groups. A total of 1115 of 40,970 registered interventional trials were assigned to otolaryngology. Head and neck cancer trials predominated. Study models most frequently incorporated parallel design (54.6%), 2 study groups (46.6%), and randomization (69.1%). Phase 2 or 3 studies constituted 46.4% of the cohort. Comparison of the ClinicalTrials.gov database with administrative health system visit data by disease condition showed discordance between national research activity and clinical visit volume for patients with otolaryngology complaints. Analysis of otolaryngology-related clinical research as listed in ClinicalTrials.gov can inform patients, physicians, and policy makers about research focus areas. The relative burden of otolaryngology-associated conditions in our tertiary health system exceeds research activity within the field.

Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database

International Nuclear Information System (INIS)

Cihoric, Nikola; Tsikkinis, Alexandros; Miguelez, Cristina Gutierrez; Strnad, Vratislav; Soldatovic, Ivan; Ghadjar, Pirus; Jeremic, Branislav; Dal Pra, Alan; Aebersold, Daniel M.; Lössl, Kristina

2016-01-01

To evaluate the current status of prospective interventional clinical trials that includes brachytherapy (BT) procedures. The records of 175,538 (100 %) clinical trials registered at ClinicalTrials.gov were downloaded on September 2014 and a database was established. Trials using BT as an intervention were identified for further analyses. The selected trials were manually categorized according to indication(s), BT source, applied dose rate, primary sponsor type, location, protocol initiator and funding source. We analyzed trials across 8 available trial protocol elements registered within the database. In total 245 clinical trials were identified, 147 with BT as primary investigated treatment modality and 98 that included BT as an optional treatment component or as part of the standard treatment. Academic centers were the most frequent protocol initiators in trials where BT was the primary investigational treatment modality (p < 0.01). High dose rate (HDR) BT was the most frequently investigated type of BT dose rate (46.3 %) followed by low dose rate (LDR) (42.0 %). Prostate was the most frequently investigated tumor entity in trials with BT as the primary treatment modality (40.1 %) followed by breast cancer (17.0 %). BT was rarely the primary investigated treatment modality for cervical cancer (6.8 %). Most clinical trials using BT are predominantly in early phases, investigator-initiated and with low accrual numbers. Current investigational activities that include BT mainly focus on prostate and breast cancers. Important questions concerning the optimal usage of BT will not be answered in the near future. The online version of this article (doi:10.1186/s13014-016-0624-8) contains supplementary material, which is available to authorized users

From Controlled Trial to Community Adoption: The Multisite Translational Community Trial

Science.gov (United States)

Murimi, Mary; Gonzalez, Anjelica; Njike, Valentine; Green, Lawrence W.

2011-01-01

Methods for translating the findings of controlled trials, such as the Diabetes Prevention Program, into real-world community application have not been clearly defined. A standardized research methodology for making and evaluating such a transition is needed. We introduce the multisite translational community trial (mTCT) as the research analog to the multisite randomized controlled trial. The mTCT is adapted to incorporate the principles and practices of community-based participatory research and the increased relevance and generalizability gained from diverse community settings. The mTCT is a tool designed to bridge the gap between what a clinical trial demonstrates can work in principle and what is needed to make it workable and effective in real-world settings. Its utility could be put to the test, in particular with practice-based research networks such as the Prevention Research Centers. PMID:21680935

Effect of race/ethnicity on participation in HIV vaccine trials and comparison to other trials of biomedical prevention.

Science.gov (United States)

Dhalla, Shayesta; Poole, Gary

2014-01-01

Racial/ethnic minorities are underrepresented in actual HIV vaccine trials in North America, and willingness to participate (WTP) and retention in an HIV vaccine trial may differ from that in Whites. In this review, the authors identified HIV vaccine preparedness studies (VPS) in North America in high-risk populations that examined the relationship between race/ethnicity and WTP in a preventive phase 3 HIV vaccine trial, and the relationship to retention. Studies were categorized by risk group, and comparison group (Whites vs. non-Whites). Other types of trials of biomedical prevention were also identified, and WTP and retention rates were compared and contrasted to actual HIV vaccine trials. In the studies identified, WTP in a hypothetical trial HIV vaccine trial did not differ by race/ethnicity. In contrast, actual HIV vaccine trials, an HIV acquisition trial, and a phase 2B preexposure prophylaxis (PrEP) trial have enrolled a large percentage of White men. Human papilloma virus (HPV) privately-funded trials have also enrolled a large number of Whites, due to convenience sampling. Retention in the HIV acquisition trial was lower in African-Americans compared with Whites. Strategies to increase WTP and enhanced retention (ER) strategies may help in recruiting and retaining minority participants in actual HIV vaccine trials and other trials of biomedical prevention.

Publication and non-publication of drug trial results: a 10-year cohort of trials in Norwegian general practice.

Science.gov (United States)

Brænd, Anja Maria; Straand, Jørund; Jakobsen, Rune Bruhn; Klovning, Atle

2016-04-11

Previously, we identified a 10-year cohort of protocols from applications to the Norwegian Medicines Agency 1998-2007, consisting of 196 drug trials in general practice. The aim of this study was to examine whether trial results were published and whether trial funding and conflicts of interest were reported. Cohort study of trials with systematic searches for published results. Clinical drug trials in Norwegian general practice. We performed systematic literature searches of MEDLINE, Embase and CENTRAL to identify publications originating from each trial using characteristics such as test drug, comparator and patient groups as search terms. When no publication was identified, we contacted trial sponsors for information regarding trial completion and reference to any publications. We determined the frequency of publication of trial results and trial characteristics associated with publication of results. Of the 196 trials, 5 were never started. Of the remaining 191 trials, 71% had results published in a journal, 11% had results publicly available elsewhere and 18% of trials had no results available. Publication was more common among trials with an active comparator drug (χ(2) test, p=0.040), with a larger number of patients (total sample size≥median, p=0.010) and with a longer trial period (duration≥median, p=0.025). Trial funding was reported in 85% of publications and increased over time, as did reporting of conflicts of interest among authors. Among the 134 main journal articles from the trials, 60% presented statistically significant results for the investigational drug, and the conclusion of the article was favourable towards the test drug in 78% of papers. We did not identify any journal publication of results for 29% of the general practice drug trials. Trials with an active comparator, larger and longer trials were more likely to be published. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

Science.gov (United States)

2013-01-01

Background Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Methods Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). Results The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. Conclusions We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials. PMID:23433341

Clinical trial optimization: Monte Carlo simulation Markov model for planning clinical trials recruitment.

Science.gov (United States)

Abbas, Ismail; Rovira, Joan; Casanovas, Josep

2007-05-01

The patient recruitment process of clinical trials is an essential element which needs to be designed properly. In this paper we describe different simulation models under continuous and discrete time assumptions for the design of recruitment in clinical trials. The results of hypothetical examples of clinical trial recruitments are presented. The recruitment time is calculated and the number of recruited patients is quantified for a given time and probability of recruitment. The expected delay and the effective recruitment durations are estimated using both continuous and discrete time modeling. The proposed type of Monte Carlo simulation Markov models will enable optimization of the recruitment process and the estimation and the calibration of its parameters to aid the proposed clinical trials. A continuous time simulation may minimize the duration of the recruitment and, consequently, the total duration of the trial.

Self-Medication: potential risks and hazards among pregnant ...

African Journals Online (AJOL)

Self-Medication: potential risks and hazards among pregnant women in Uyo, ... Reasons for using these substances range from protection from witches and ... shows that self-medication is common among pregnant women in our environment.

Seiklused kapitaguses maailmas / Karin Hansson

Index Scriptorium Estoniae

Hansson, Karin

2007-01-01

C.S. Lewise 1950.a. ilmunud romaani järgi "Narnia lood : Lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") valminud Andrew Adamsoni samanimelisest mängufilmist

Methodology series module 4: Clinical trials

Directory of Open Access Journals (Sweden)

Maninder Singh Setia

2016-01-01

Full Text Available In a clinical trial, study participants are (usually divided into two groups. One group is then given the intervention and the other group is not given the intervention (or may be given some existing standard of care. We compare the outcomes in these groups and assess the role of intervention. Some of the trial designs are (1 parallel study design, (2 cross-over design, (3 factorial design, and (4 withdrawal group design. The trials can also be classified according to the stage of the trial (Phase I, II, III, and IV or the nature of the trial (efficacy vs. effectiveness trials, superiority vs. equivalence trials. Randomization is one of the procedures by which we allocate different interventions to the groups. It ensures that all the included participants have a specified probability of being allocated to either of the groups in the intervention study. If participants and the investigator know about the allocation of the intervention, then it is called an "open trial." However, many of the trials are not open - they are blinded. Blinding is useful to minimize bias in clinical trials. The researcher should familiarize themselves with the CONSORT statement and the appropriate Clinical Trials Registry of India.

Preliminary evaluation of factors associated with premature trial closure and feasibility of accrual benchmarks in phase III oncology trials.

Science.gov (United States)

Schroen, Anneke T; Petroni, Gina R; Wang, Hongkun; Gray, Robert; Wang, Xiaofei F; Cronin, Walter; Sargent, Daniel J; Benedetti, Jacqueline; Wickerham, Donald L; Djulbegovic, Benjamin; Slingluff, Craig L

2010-08-01

A major challenge for randomized phase III oncology trials is the frequent low rates of patient enrollment, resulting in high rates of premature closure due to insufficient accrual. We conducted a pilot study to determine the extent of trial closure due to poor accrual, feasibility of identifying trial factors associated with sufficient accrual, impact of redesign strategies on trial accrual, and accrual benchmarks designating high failure risk in the clinical trials cooperative group (CTCG) setting. A subset of phase III trials opened by five CTCGs between August 1991 and March 2004 was evaluated. Design elements, experimental agents, redesign strategies, and pretrial accrual assessment supporting accrual predictions were abstracted from CTCG documents. Percent actual/predicted accrual rate averaged per month was calculated. Trials were categorized as having sufficient or insufficient accrual based on reason for trial termination. Analyses included univariate and bivariate summaries to identify potential trial factors associated with accrual sufficiency. Among 40 trials from one CTCG, 21 (52.5%) trials closed due to insufficient accrual. In 82 trials from five CTCGs, therapeutic trials accrued sufficiently more often than nontherapeutic trials (59% vs 27%, p = 0.05). Trials including pretrial accrual assessment more often achieved sufficient accrual than those without (67% vs 47%, p = 0.08). Fewer exclusion criteria, shorter consent forms, other CTCG participation, and trial design simplicity were not associated with achieving sufficient accrual. Trials accruing at a rate much lower than predicted (accrual rate) were consistently closed due to insufficient accrual. This trial subset under-represents certain experimental modalities. Data sources do not allow accounting for all factors potentially related to accrual success. Trial closure due to insufficient accrual is common. Certain trial design factors appear associated with attaining sufficient accrual. Defining

Parents' perceived obstacles to pediatric clinical trial participation: Findings from the clinical trials transformation initiative.

Science.gov (United States)

Greenberg, Rachel G; Gamel, Breck; Bloom, Diane; Bradley, John; Jafri, Hasan S; Hinton, Denise; Nambiar, Sumathi; Wheeler, Chris; Tiernan, Rosemary; Smith, P Brian; Roberts, Jamie; Benjamin, Daniel K

2018-03-01

Enrollment of children into pediatric clinical trials remains challenging. More effective strategies to improve recruitment of children into trials are needed. This study used in-depth qualitative interviews with parents who were approached to enroll their children in a clinical trial in order to gain an understanding of the barriers to pediatric clinical trial participation. Twenty-four parents whose children had been offered the opportunity to participate in a clinical trial were interviewed: 19 whose children had participated in at least 1 clinical trial and 5 who had declined participation in any trial. Each study aspect, from the initial explanation of the study to the end of the study, can affect the willingness of parents to consent to the proposed study and future studies. Establishing trust, appropriate timing, a transparent discussion of risks and benefits oriented to the layperson, and providing motivation for children to participate were key factors that impacted parents' decisions. In order for clinical trial accrual to be successful, parents' priorities and considerations must be a central focus, beginning with initial trial design. The recommendations from the parents who participated in this study can be used to support budget allocations that ensure adequate training of study staff and improved staffing on nights and weekends. Studies of parent responses in outpatient settings and additional inpatient settings will provide valuable information on the consent process from the child's and parent's perspectives. Further studies are needed to explore whether implementation of such strategies will result in improved recruitment for pediatric clinical trials.

The Values of Masculinity in William Shakespeare’s Macbeth

Directory of Open Access Journals (Sweden)

Mafruha Ferdous

2017-04-01

Full Text Available The theme of gender plays a vital role in William Shakespeare’s famous political play Macbeth. From the very beginning of the play the dramatist focuses on the importance of masculinity in gaining power and authority. Lady Macbeth along with the three witches are as important characters as Macbeth. Because they influence Macbeth profoundly. And Shakespeare very carefully draws the character of Lady Macbeth who being a female sometimes exhibits more masculinity than Macbeth. Similarly is the case of the three witches. Though they look like women they are also bearded which prove the presence of masculinity in their nature. Throughout the play several times the exposition of masculinity is demanded from the character of Macbeth. So the value of masculinity plays an important part in the drama.

“Machos y brujas en la Patagonia”. Trabajo, masculinidad y espacio de la reproducción

Directory of Open Access Journals (Sweden)

Hernán M. Palermo

2016-05-01

Full Text Available The title "Machos and Witches in Patagonia" illustrates the core debate of this article and attempts to problematize the processes emphasized by social class and gender relations. "Machos" refers to the social construction of the oil worker as imposed by the production system. Meanwhile, "witches” refers to the witch-hunts of the sixteenth, seventeenth and eighteenth centuries, and the practice in which women were confined to the domestic sphere and their reproductive role of the workforce. Therefore, we want to analyze the link between the production process of the oil workforce inside the production system and outside of their work experiences in Comodoro Rivadavia, Argentinian Patagonia. Given that masculinity and femininity are relational gender positions, we will discuss the role of men and women in the organization of work, as a whole.

MedlinePlus: Surgery Videos

Science.gov (United States)

... Shawnee Mission, KS, 3/05/2014) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ... Winston-Salem, NC, 1/15/2009) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ...

The Trial of Napoleon: A Case Study for Using Mock Trials.

Science.gov (United States)

MacKay, Charles

2000-01-01

Describes a course entitled "The Trial of Napoleon Bonaparte" that focuses on a fictitious mock trial of Napoleon Bonaparte to answer the question: did Napoleon pervert or preserve the gain of the French Revolution? Discusses the strengths and weaknesses of the course. (CMK)

Are pilot trials useful for predicting randomisation and attrition rates in definitive studies: A review of publicly funded trials

Science.gov (United States)

Whitehead, Amy; Pottrill, Edward; Julious, Steven A; Walters, Stephen J

2018-01-01

Background/aims: External pilot trials are recommended for testing the feasibility of main or confirmatory trials. However, there is little evidence that progress in external pilot trials actually predicts randomisation and attrition rates in the main trial. To assess the use of external pilot trials in trial design, we compared randomisation and attrition rates in publicly funded randomised controlled trials with rates in their pilots. Methods: Randomised controlled trials for which there was an external pilot trial were identified from reports published between 2004 and 2013 in the Health Technology Assessment Journal. Data were extracted from published papers, protocols and reports. Bland–Altman plots and descriptive statistics were used to investigate the agreement of randomisation and attrition rates between the full and external pilot trials. Results: Of 561 reports, 41 were randomised controlled trials with pilot trials and 16 met criteria for a pilot trial with sufficient data. Mean attrition and randomisation rates were 21.1% and 50.4%, respectively, in the pilot trials and 16.8% and 65.2% in the main. There was minimal bias in the pilot trial when predicting the main trial attrition and randomisation rate. However, the variation was large: the mean difference in the attrition rate between the pilot and main trial was −4.4% with limits of agreement of −37.1% to 28.2%. Limits of agreement for randomisation rates were −47.8% to 77.5%. Conclusion: Results from external pilot trials to estimate randomisation and attrition rates should be used with caution as comparison of the difference in the rates between pilots and their associated full trial demonstrates high variability. We suggest using internal pilot trials wherever appropriate. PMID:29361833

Make believe ja skisofreenia : külaskäik Blairi nõia juurde / Peeter Linnap

Index Scriptorium Estoniae

Linnap, Peeter, 1960-

2000-01-01

Mängufilm "Blairi nõiafilm" ("The Blair Witch Project") : Stsenaristid ja režissöörid Eduardo Sanchez ja Daniel Myrick : Ameerika Ühendriigid 1999. Eesti dokumentalistika ja tegelikkuse kujutamise trendid eesti uuemas filmis

Pediatric Clinical Trials Conducted in South Korea from 2006 to 2015: An Analysis of the South Korean Clinical Research Information Service, US ClinicalTrials.gov and European Clinical Trials Registries.

Science.gov (United States)

Choi, Sheung-Nyoung; Lee, Ji-Hyun; Song, In-Kyung; Kim, Eun-Hee; Kim, Jin-Tae; Kim, Hee-Soo

2017-12-01

The status of pediatric clinical trials performed in South Korea in the last decade, including clinical trials of drugs with unapproved indications for children, has not been previously examined. The aim was to provide information regarding the current state of pediatric clinical trials and create a basis for future trials performed in South Korea by reviewing three databases of clinical trials registrations. We searched for pediatric clinical studies (participants South Korea between 2006 and 2015 registered on the Clinical Research Information Service (CRIS), ClinicalTrials.gov, and the European Clinical Trials Registry (EuCTR). Additionally, we reviewed whether unapproved indications were involved in each trial by comparing the trials with a list of authorized trials provided by the Ministry of Food and Drug Safety (MFDS). The primary and secondary outcomes were to determine the change in number of pediatric clinical trials with unapproved indications over time and to assess the status of unauthorized pediatric clinical trials from the MFDS and the publication of articles after these clinical trials, respectively. We identified 342 clinical studies registered in the CRIS (n = 81), ClinicalTrials.gov (n = 225), and EuCTR (n = 36), of which 306 were reviewed after excluding duplicate registrations. Among them, 181 studies were interventional trials dealing with drugs and biological agents, of which 129 (71.3%) involved unapproved drugs. Of these 129 trials, 107 (82.9%) were authorized by the MFDS. Pediatric clinical trials in South Korea aiming to establish the safety and efficacy of drugs in children are increasing; however, non-MFDS-authorized studies remain an issue.

Medline Plus

Full Text Available ... Hospital, Greenville, SC, 6/14/2013) Brain and Nerves Back Pain SI (Sacroiliac) Fusion Surgery (Broward Health ... Wounds and Injuries Repair of Flexor Tendon and Nerve (Wake Forest Baptist Medical Center, Winston-Salem, NC, ...

Scientific Results of Yoga for Health and Well-Being

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Full Text Available ... and joints in certain yoga postures. (George Salem, Ph.D., University of Southern California) An overview of ... common and difficult-to-treat problem. (Karen Sherman, Ph.D., M.P.H., Group Health Research Institute) ...

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Full Text Available ... Forest University Baptist Medical Center, Winston-Salem, NC, 12/16/13) Transesophageal Echocardiogram (TEE) (Shawnee Mission Medical ... Broward Health Medical Center, Fort Lauderdale, FL, 5/12/2014) Total Ankle Replacement (Doctors Hospital, Coral Gables, ...

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JCSC_128_11_1725_1735_SI.docx

Indian Academy of Sciences (India)

Windows7

Ruthenium(II) complexes bearing pyridine-functionalized N-heterocyclic carbene ligands: Synthesis, structure and catalytic application over amide synthesis. MUTHUKUMARAN NIRMALA and PERIASAMY VISWANATHAMURTHI*. Department of Chemistry, Periyar University, Salem, Tamil Nadu 636 011, India. e-mail: ...

supp2.doc

Indian Academy of Sciences (India)

Panneerselvam Anithaa, Rajendran Manikandana, Paranthaman Vijayana, Govindan Prakasha, Periasamy Viswanathamurthia,* and Ray Jay Butcherb. a Department of Chemistry, Periyar University, Salem-636011, Tamil Nadu, India. b Department of Chemistry, Howard University, 525 College Street NW, Washington, DC ...

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Scientific Results of Yoga for Health and Well-Being

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Full Text Available ... muscles and joints in certain yoga postures. (George Salem, Ph.D., University of Southern California) An overview ... was launched September 2010. Learn more about yoga Press release NCCIH has provided this material for your ...

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Full Text Available ... Mission Medical Center, Merriam, KS, 05/04/2012) Kidney Cancer Robot Assisted Partial Nephrectomy Using Fluorescence (Shawnee ... Medical Center, Winston-Salem, NC, 09/17/2015) Kidneys and Urinary System Kidney Cancer Robot Assisted Partial ...

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Full Text Available ... Winston-Salem, NC, 1/15/2009) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ... Boston, Boston, MA, 6/08/2010) Weight Loss Surgery Laparoscopic Gastric Bypass Surgery (University of Miami Hospital ...

Credentialing for participation in clinical trials

International Nuclear Information System (INIS)

Followill, David S.; Urie, Marcia; Galvin, James M.; Ulin, Kenneth; Xiao, Ying; FitzGerald, Thomas J.

2012-01-01

The National Cancer Institute (NCI) clinical cooperative groups have been instrumental over the past 50 years in developing clinical trials and evidence-based clinical trial processes for improvements in patient care. The cooperative groups are undergoing a transformation process to launch, conduct, and publish clinical trials more rapidly. Institutional participation in clinical trials can be made more efficient and include the expansion of relationships with international partners. This paper reviews the current processes that are in use in radiation therapy trials and the importance of maintaining effective credentialing strategies to assure the quality of the outcomes of clinical trials. The paper offers strategies to streamline and harmonize credentialing tools and processes moving forward as the NCI undergoes transformative change in the conduct of clinical trials.

Credentialing for participation in clinical trials

Energy Technology Data Exchange (ETDEWEB)

Followill, David S. [Radiological Physics Center, Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Urie, Marcia [Quality Assurance Review Center, Department of Radiation Oncology, University of Massachusetts Medical School, Lincoln, RI (United States); Galvin, James M. [Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA (United States); Radiation Therapy Oncology Group, Philadelphia, PA (United States); Ulin, Kenneth [Quality Assurance Review Center, Department of Radiation Oncology, University of Massachusetts Medical School, Lincoln, RI (United States); Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA (United States); Xiao, Ying [Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA (United States); Radiation Therapy Oncology Group, Philadelphia, PA (United States); FitzGerald, Thomas J., E-mail: dfollowi@mdanderson.org [Quality Assurance Review Center, Department of Radiation Oncology, University of Massachusetts Medical School, Lincoln, RI (United States); Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, MA (United States)

2012-12-26

The National Cancer Institute (NCI) clinical cooperative groups have been instrumental over the past 50 years in developing clinical trials and evidence-based clinical trial processes for improvements in patient care. The cooperative groups are undergoing a transformation process to launch, conduct, and publish clinical trials more rapidly. Institutional participation in clinical trials can be made more efficient and include the expansion of relationships with international partners. This paper reviews the current processes that are in use in radiation therapy trials and the importance of maintaining effective credentialing strategies to assure the quality of the outcomes of clinical trials. The paper offers strategies to streamline and harmonize credentialing tools and processes moving forward as the NCI undergoes transformative change in the conduct of clinical trials.

Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience

Directory of Open Access Journals (Sweden)

Zielinski Stephanie M

2012-01-01

Full Text Available Abstract Background Surgeons in the Netherlands, Canada and the US participate in the FAITH trial (Fixation using Alternative Implants for the Treatment of Hip fractures. Dutch sites are managed and visited by a financed central trial coordinator, whereas most Canadian and US sites have local study coordinators and receive per patient payment. This study was aimed to assess how these different trial management strategies affected trial performance. Methods Details related to obtaining ethics approval, time to trial start-up, inclusion, and percentage completed follow-ups were collected for each trial site and compared. Pre-trial screening data were compared with actual inclusion rates. Results Median trial start-up ranged from 41 days (P25-P75 10-139 in the Netherlands to 232 days (P25-P75 98-423 in Canada (p = 0.027. The inclusion rate was highest in the Netherlands; median 1.03 patients (P25-P75 0.43-2.21 per site per month, representing 34.4% of the total eligible population. It was lowest in Canada; 0.14 inclusions (P25-P75 0.00-0.28, representing 3.9% of eligible patients (p Conclusions In this trial, a central financed trial coordinator to manage all trial related tasks in participating sites resulted in better trial progression and a similar follow-up. It is therefore a suitable alternative for appointing these tasks to local research assistants. The central coordinator approach can enable smaller regional hospitals to participate in multicenter randomized controlled trials. Circumstances such as available budget, sample size, and geographical area should however be taken into account when choosing a management strategy. Trial Registration ClinicalTrials.gov: NCT00761813

Dicty_cDB: Contig-U02501-1 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available ) Aster yellows witches'-broom phytoplasma AYWB, co... 38 0.006 12 ( FG289263 ) 1108793295629 New World Scre...FG290297 ) 1108793315558 New World Screwworm Egg 9261 ESTs C... 44 9.4 1 ( FE7256

How to Talk to the Supernatural in Shakespeare.

Science.gov (United States)

Yonglin, Yang

1991-01-01

Examines Shakespeare's use of thou forms to individual ghosts, witches, and spirits. The proposition is advanced that there is a role-governed rule in the use of this pronoun to individual supernatural beings. (31 references) (GLR)

Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications.

Science.gov (United States)

Kasenda, Benjamin; Schandelmaier, Stefan; Sun, Xin; von Elm, Erik; You, John; Blümle, Anette; Tomonaga, Yuki; Saccilotto, Ramon; Amstutz, Alain; Bengough, Theresa; Meerpohl, Joerg J; Stegert, Mihaela; Olu, Kelechi K; Tikkinen, Kari A O; Neumann, Ignacio; Carrasco-Labra, Alonso; Faulhaber, Markus; Mulla, Sohail M; Mertz, Dominik; Akl, Elie A; Bassler, Dirk; Busse, Jason W; Ferreira-González, Ignacio; Lamontagne, Francois; Nordmann, Alain; Gloy, Viktoria; Raatz, Heike; Moja, Lorenzo; Rosenthal, Rachel; Ebrahim, Shanil; Vandvik, Per O; Johnston, Bradley C; Walter, Martin A; Burnand, Bernard; Schwenkglenks, Matthias; Hemkens, Lars G; Bucher, Heiner C; Guyatt, Gordon H; Briel, Matthias

2014-07-16

To investigate the planning of subgroup analyses in protocols of randomised controlled trials and the agreement with corresponding full journal publications. Cohort of protocols of randomised controlled trial and subsequent full journal publications. Six research ethics committees in Switzerland, Germany, and Canada. 894 protocols of randomised controlled trial involving patients approved by participating research ethics committees between 2000 and 2003 and 515 subsequent full journal publications. Of 894 protocols of randomised controlled trials, 252 (28.2%) included one or more planned subgroup analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least one subgroup analysis, 10 (4.0%) anticipated the direction of a subgroup effect, and 87 (34.5%) planned a statistical test for interaction. Industry sponsored trials more often planned subgroup analyses compared with investigator sponsored trials (195/551 (35.4%) v 57/343 (16.6%), P<0.001). Of 515 identified journal publications, 246 (47.8%) reported at least one subgroup analysis. In 81 (32.9%) of the 246 publications reporting subgroup analyses, authors stated that subgroup analyses were prespecified, but this was not supported by 28 (34.6%) corresponding protocols. In 86 publications, authors claimed a subgroup effect, but only 36 (41.9%) corresponding protocols reported a planned subgroup analysis. Subgroup analyses are insufficiently described in the protocols of randomised controlled trials submitted to research ethics committees, and investigators rarely specify the anticipated direction of subgroup effects. More than one third of statements in publications of randomised controlled trials about subgroup prespecification had no documentation in the corresponding protocols. Definitive judgments regarding credibility of claimed subgroup effects are not possible without access to protocols and analysis plans of randomised controlled trials. © The DISCO study group 2014.

Trial 1 versus Trial 2 of the Test of Memory Malingering: Evaluating accuracy without a "gold standard".

Science.gov (United States)

Mossman, Douglas; Wygant, Dustin B; Gervais, Roger O; Hart, Kathleen J

2018-01-01

This study examines the accuracy of the Test of Memory Malingering (TOMM), a frequently administered measure for evaluating effort during neurocognitive testing. In the last few years, several authors have suggested that the initial recognition trial of the TOMM (Trial 1) might be a more useful index for detecting feigned or exaggerated impairment than Trial 2, which is the source for inference recommended by the original instruction manual (Tombaugh, 1996). We used latent class modeling (LCM) implemented in a Bayesian framework to evaluate archival Trial 1 and Trial 2 data collected from 1,198 adults who had undergone outpatient forensic evaluations. All subjects were tested with 2 other performance validity tests (the Word Memory Test and the Computerized Assessment of Response Bias), and for 70% of the subjects, data from the California Verbal Learning Test-Second Edition Forced Choice trial were also available. Our results suggest that not even a perfect score on Trial 1 or Trial 2 justifies saying that an evaluee is definitely responding genuinely, although such scores imply a lower-than-base-rate probability of feigning. If one uses a Trial 2 cut-off higher than the manual's recommendation, Trial 2 does better than Trial 1 at identifying individuals who are almost certainly feigning while maintaining a negligible false positive rate. Using scores from both trials, one can identify a group of definitely feigning and very likely feigning subjects who comprise about 2 thirds of all feigners; only 1% of the members of this group would not be feigning. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Research Areas - Clinical Trials

Science.gov (United States)

Information about NCI programs and initiatives that sponsor, conduct, develop, or support clinical trials, including NCI’s Clinical Trial Network (NCTN) and NCI Community Oncology Research Program (NCORP) initiatives.

Study of the trial subjects’ protection aspects in Phase I clinical trials and bioequivalence studies

Directory of Open Access Journals (Sweden)

K. O. Zupanets

2016-03-01

Full Text Available Protection of rights, health and well-being of persons who are taking the drug during the trial (trial subjects is one of the basic principles of clinical trials (CT management. Aim. In order to study key aspects of volunteer protection, determine factors that influence these indicators and estimate the importance of ensuring their proper implementation on the clinical site (CS three survey of 135 trial subjects were carried out to evaluate the importance of assessing the impact of factors such as the procedure of signing the informed consent (IC at the CS and testing procedures for HIV / AIDS, hepatitis and others. Assessment of the quality of life of trial subjects as indirect indicator of the quality of clinical trials that ensures the proper protection of their life was the subject of the third survey. Methods and results. The general model of the relationship between the key aspects of the trial subjects protection and the factors which are providing them during the clinical trials of drugs management was substantiated, which included the main aspects of the trial subjects’ protection, protective factors and basic CT management procedures, the impact of the above factors on the possibility of providing protection aspects depends on their implementation quality. It was found that trial subjects’ protection improvement can be achieved during the IC signing process. It is necessary to ensure a higher level of volunteers understanding of the terms that could be used in the IC form. Regarding the procedure of compulsory testing for HIV/AIDS in the course of screening, we can conclude that the majority of the trial subjects believe that this procedure is an additional factor in their health protection and do not consider it as an excessive psychological pressure on them. Conclusion. Assessing the quality of life during the bioequivalence study at the CS makes possible to reach a conclusion on general well-being and satisfaction with those

Sequential Multiple Assignment Randomized Trials: An Opportunity for Improved Design of Stroke Reperfusion Trials.

Science.gov (United States)

Meurer, William J; Seewald, Nicholas J; Kidwell, Kelley

2017-04-01

Modern clinical trials in stroke reperfusion fall into 2 categories: alternative systemic pharmacological regimens to alteplase and "rescue" endovascular approaches using targeted thrombectomy devices and/or medications delivered directly for persistently occluded vessels. Clinical trials in stroke have not evaluated how initial pharmacological thrombolytic management might influence subsequent rescue strategy. A sequential multiple assignment randomized trial (SMART) is a novel trial design that can test these dynamic treatment regimens and lead to treatment guidelines that more closely mimic practice. To characterize a SMART design in comparison to traditional approaches for stroke reperfusion trials. We conducted a numerical simulation study that evaluated the performance of contrasting acute stroke clinical trial designs of both initial reperfusion and rescue therapy. We compare a SMART design where the same patients are followed through initial reperfusion and rescue therapy within 1 trial to a standard phase III design comparing 2 reperfusion treatments and a separate phase II futility design of rescue therapy in terms of sample size, power, and ability to address particular research questions. Traditional trial designs can be well powered and have optimal design characteristics for independent treatment effects. When treatments, such as the reperfusion and rescue therapies, may interact, commonly used designs fail to detect this. A SMART design, with similar sample size to standard designs, can detect treatment interactions. The use of SMART designs to investigate effective and realistic dynamic treatment regimens is a promising way to accelerate the discovery of new, effective treatments for stroke. Copyright © 2017 National Stroke Association. Published by Elsevier Inc. All rights reserved.

Do thinning and prescribed burning affect the growth of shortleaf pine?

Science.gov (United States)

H. A. Somes; G. R. Moorhead

1954-01-01

In January 1946 a small study of thinning and prescribed burning was started in an old-field stand mostly of shortleaf pines about 38 years old. The stand is located on private land in Salem County, N. J.

"Keset filmi" Kiasmas

Index Scriptorium Estoniae

2004-01-01

Soome kunstniku Tellervo Kalleineni filmiprojektist "In the middle of a movie'". Eestist esinesid projektis Taavi Eelmaa, Tarrvi Laamann, Silva Lutz, Anders Melts, Anneli Remme, Siiri Salem, Martin Palm, Kaja Prikk, Peeter Ristsoo, filmisid Peeter Maimik ja Marianne Kõrver

Clean Hands Count

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Full Text Available ... 5 Moments of Hand Hygiene - Duration: 1:53. Salem Health 13,972 views 1:53 Hand Hygiene ... Mode: Off History Help Loading... Loading... Loading... About Press Copyright Creators Advertise Developers +YouTube Terms Privacy Policy & ...

Italy backs Third World science body...

CERN Multimedia

Dickson, D

1998-01-01

The Italian government announced that it has agreed to make a long term financial commitment to the Third World Academy of Science (TWAS), set up in 1983 at the initiative of the physicist and Nobel laureate Abdus Salem.

Patient engagement in clinical trials: The Clinical Trials Transformation Initiative's leadership from theory to practical implementation.

Science.gov (United States)

Patrick-Lake, Bray

2018-02-01

Patient engagement is an increasingly important aspect of successful clinical trials. Over the past decade, as patient group involvement in clinical trials has continued to increase and diversify, the Clinical Trials Transformation Initiative has not only recognized the crucial role patients play in improving the clinical trial enterprise but also made a deep commitment to help grow and shape the emerging field of patient engagement. This article describes the evolution of patient engagement including the origins of the patient engagement movement; barriers to successful engagement and remaining challenges to full and valuable collaboration between patient groups and trial sponsors; and Clinical Trials Transformation Initiative's role in influencing the field through organizational practices, formal project work and resulting recommendations, and external advocacy efforts.

Lung-MAP Launches: First Precision Medicine Trial From National Clinical Trials Network

Science.gov (United States)

A unique public-private collaboration today announced the initiation of the Lung Cancer Master Protocol (Lung-MAP) trial, a multi-drug, multi-arm, biomarker-driven clinical trial for patients with advanced squamous cell lung cancer. Squamous cell carcinom

Transparency and public accessibility of clinical trial information in Croatia: how it affects patient participation in clinical trials.

Science.gov (United States)

Šolić, Ivana; Stipčić, Ana; Pavličević, Ivančica; Marušić, Ana

2017-06-15

Despite increased visibility of clinical trials through international trial registries, patients often remain uninformed of their existence, especially if they do not have access to adequate information about clinical research, including the language of the information. The aim of this study was to describe the context for transparency of clinical trials in Croatia in relation to countries in Central and Eastern Europe, and to assess how informed Croatian patients are about clinical trials and their accessibility. We assessed the transparency of clinical trials from the data available in the public domain. We also conducted an anonymous survey on a convenience sample of 257 patients visiting two family medicine offices or an oncology department in south Croatia, and members of national patients' associations. Despite legal provisions for transparency of clinical trials in Croatia, they are still not sufficiently visible in the public domain. Among countries from Central and Eastern Europe, Croatia has the fewest number of registered trials in the EU Clinical Trials Registry. 66% of the patients in the survey were aware of the existence of clinical trials but only 15% were informed about possibilities of participating in a trial. Although 58% of the respondents were willing to try new treatments, only 6% actually participated in a clinical trial. Only 2% of the respondents were aware of publicly available trial registries. Our study demonstrates that there is low transparency of clinical trials in Croatia, and that Croatian patients are not fully aware of clinical trials and the possibilities of participating in them, despite reported availability of Internet resources and good communication with their physicians. There is a need for active policy measures to increase the awareness of and access to clinical trials to patients in Croatia, particularly in their own language.

Critical concepts in adaptive clinical trials

Directory of Open Access Journals (Sweden)

Park JJH

2018-03-01

Full Text Available Jay JH Park,1 Kristian Thorlund,2,3 Edward J Mills2,3 1Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 2Department of Health Research Methods, Evidence, and Impact (HEI, McMaster University, Hamilton, ON, Canada; 3The Bill and Melinda Gates Foundation, Seattle, WA, USA Abstract: Adaptive clinical trials are an innovative trial design aimed at reducing resources, decreasing time to completion and number of patients exposed to inferior interventions, and improving the likelihood of detecting treatment effects. The last decade has seen an increasing use of adaptive designs, particularly in drug development. They frequently differ importantly from conventional clinical trials as they allow modifications to key trial design components during the trial, as data is being collected, using preplanned decision rules. Adaptive designs have increased likelihood of complexity and also potential bias, so it is important to understand the common types of adaptive designs. Many clinicians and investigators may be unfamiliar with the design considerations for adaptive designs. Given their complexities, adaptive trials require an understanding of design features and sources of bias. Herein, we introduce some common adaptive design elements and biases and specifically address response adaptive randomization, sample size reassessment, Bayesian methods for adaptive trials, seamless trials, and adaptive enrichment using real examples. Keywords: adaptive designs, response adaptive randomization, sample size reassessment, Bayesian adaptive trials, seamless trials, adaptive enrichment

Narnija, ili V platjanoi shkaf i obratno / Nikolai Karajev

Index Scriptorium Estoniae

Karajev, Nikolai, 1978-

2005-01-01

Ekraniseering C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") : režissöör Andrew Adamson : Ameerika Ühendriigid 2005

Konservativnaja metshta Narnii / Sven Vabar

Index Scriptorium Estoniae

Vabar, Sven

2006-01-01

Ekraniseering C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") : režissöör Andrew Adamson : Ameerika Ühendriigid 2005

Narnia konservatiivne unelm / Sven Vabar

Index Scriptorium Estoniae

Vabar, Sven

2006-01-01

Ekraniseering C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") : režissöör Andrew Adamson : Ameerika Ühendriigid 2005

Final Remedial Investigation Report Area of Contamination (AOC) 57. Volume I. Text Sections 1 Through 10, Figures and Tables

Science.gov (United States)

2000-06-01

choke cherry ( Prunus virginiana ), maleberry (Lyonia ligustrina), and paper birch (Betula papyrifera). Herbaceous species observed in this habitat...portion of this habitat include sheep laurel, witch hazel (Hamamelis virginiana ), nannyberry, choke cherry, clubmoss (Lycopodium carolinianum), and ferns

Skazka ne po zubam / Katja Tarhanova

Index Scriptorium Estoniae

Tarhanova, Katja

2006-01-01

Ekraniseering C.S. Lewise 1950.a. ilmunud romaanist "Narnia lood : Lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") : režissöör Anrew Adamson : Ameerika Ühendriigid 2005

Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials

Energy Technology Data Exchange (ETDEWEB)

Logan, Jennifer K.; Tang, Chad; Liao, Zhongxing [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Lee, J. Jack [Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Heymach, John V. [Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen G. [Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Welsh, James W. [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Zhang, Jianjun [Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Lin, Steven H. [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Gomez, Daniel R., E-mail: dgomez@mdanderson.org [Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

2017-03-15

Purpose: Challenges can arise when attempting to maximize patient enrollment in clinical trials. There have been limited studies focusing on the barriers to enrollment and the efficacy of alternative study design to improve accrual. We analyzed barriers to clinical trial enrollment, particularly the influence of timing, in context of three prospective, randomized oncology trials where one arm was considered more aggressive than the other. Methods and Materials: From June 2011 to March 2015, patients who were enrolled on 3 prospective institutional protocols (an oligometastatic non-small cell lung cancer [NSCLC] trial and 2 proton vs intensity modulated radiation therapy trials in NSCLC and esophageal cancer) were screened for protocol eligibility. Eligible candidates were approached about trial participation, and patient characteristics (age, sex, T/N categorization) were recorded along with details surrounding trial presentation (appointment number). Fisher's exact test, Student's t tests, and multivariate analysis were performed to assess differences between enrolled and refusal patients. Results: A total of 309 eligible patients were approached about trial enrollment. The enrollment success rate during this time span was 52% (n=160 patients). Enrolled patients were more likely to be presented trial information at an earlier appointment (oligometastatic protocol: 5 vs 3 appointments [P<.001]; NSCLC protocol: 4 vs 3 appointments [P=.0018]; esophageal protocol: 3 vs 2 appointments [P=.0086]). No other factors or patient characteristics significantly affected enrollment success rate. Conclusion: Improvement in enrollment rates for randomized control trials is possible, even in difficult accrual settings. Earlier presentation of trial information to patients is the most influential factor for success and may help overcome accrual barriers without compromising trial design.

Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective, Randomized, Controlled Trials

International Nuclear Information System (INIS)

Logan, Jennifer K.; Tang, Chad; Liao, Zhongxing; Lee, J. Jack; Heymach, John V.; Swisher, Stephen G.; Welsh, James W.; Zhang, Jianjun; Lin, Steven H.; Gomez, Daniel R.

2017-01-01

Purpose: Challenges can arise when attempting to maximize patient enrollment in clinical trials. There have been limited studies focusing on the barriers to enrollment and the efficacy of alternative study design to improve accrual. We analyzed barriers to clinical trial enrollment, particularly the influence of timing, in context of three prospective, randomized oncology trials where one arm was considered more aggressive than the other. Methods and Materials: From June 2011 to March 2015, patients who were enrolled on 3 prospective institutional protocols (an oligometastatic non-small cell lung cancer [NSCLC] trial and 2 proton vs intensity modulated radiation therapy trials in NSCLC and esophageal cancer) were screened for protocol eligibility. Eligible candidates were approached about trial participation, and patient characteristics (age, sex, T/N categorization) were recorded along with details surrounding trial presentation (appointment number). Fisher's exact test, Student's t tests, and multivariate analysis were performed to assess differences between enrolled and refusal patients. Results: A total of 309 eligible patients were approached about trial enrollment. The enrollment success rate during this time span was 52% (n=160 patients). Enrolled patients were more likely to be presented trial information at an earlier appointment (oligometastatic protocol: 5 vs 3 appointments [P<.001]; NSCLC protocol: 4 vs 3 appointments [P=.0018]; esophageal protocol: 3 vs 2 appointments [P=.0086]). No other factors or patient characteristics significantly affected enrollment success rate. Conclusion: Improvement in enrollment rates for randomized control trials is possible, even in difficult accrual settings. Earlier presentation of trial information to patients is the most influential factor for success and may help overcome accrual barriers without compromising trial design.

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Full Text Available ... Coral Springs, FL, 3/31/2014) Digestive System Bile Duct Cancer Diagnosing & Treating Digestive Tract Disorders Endoscopically (Wake ... Medical Center, Winston-Salem, NC, 1/15/2009) Bile Duct Diseases Diagnosing & Treating Digestive Tract Disorders Endoscopically (Wake ...

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Full Text Available ... Shawnee Mission, KS, 3/05/2014) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ... Winston-Salem, NC, 1/15/2009) Brain Tumors Awake Craniotomy (Methodist University Hospital Memphis, TN, 4/21/2009) ...

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Full Text Available ... Mission Medical Center, Merriam, KS, 10/17/2012) Liver Cancer Segment V Liver Resection (University of Arizona Medical ... Medical Center, Winston-Salem, NC, 1/15/2009) Liver Cancer Segment V Liver Resection (University of Arizona Medical ...

Geochemical aspects of Meretrix casta (bivalve) shells of Vellar ...

African Journals Online (AJOL)

SAM

2014-05-14

May 14, 2014 ... The bivalve mollusk, Meretrix casta shells are abundant in the Vellar estuary along the East .... the Shervarayan hills of Salem District in Tamil Nadu, India. .... coast of Peninsular Malaysia and its potential as biomaterial for use.

Comparability of prostate trials

DEFF Research Database (Denmark)

Suciu, S; Sylvester, R; Iversen, P

1993-01-01

The present overview of advanced prostate cancer required the identification of randomized clinical trials studying the question of maximal androgen blockade versus the classic castration therapy. The heterogeneity of the trials concerned the type of castration (surgical or chemical) and the type...... of antiandrogen (flutamide, Anandron, or cyproterone acetate) added to castration. This paper reviews the different types of heterogeneity that might exist among trials that are involved in the overview: study design, randomization procedure, treatment evaluation, statistical evaluation, and data maturity....... In order to overcome these various types of heterogeneity and to compare like with like, the treatment comparison should be stratified a posteriori by question (i.e., type of castration or type of anti-androgen studied) and by study. In this way, one may draw valid conclusions. Of course, those trials...

Clinical trials transparency and the Trial and Experimental Studies Transparency (TEST) act.

Science.gov (United States)

Logvinov, Ilana

2014-03-01

Clinical trial research is the cornerstone for successful advancement of medicine that provides hope for millions of people in the future. Full transparency in clinical trials may allow independent investigators to evaluate study designs, perform additional analysis of data, and potentially eliminate duplicate studies. Current regulatory system and publishers rely on investigators and pharmaceutical industries for complete and accurate reporting of results from completed clinical trials. Legislation seems to be the only way to enforce mandatory disclosure of results. The Trial and Experimental Studies Transparency (TEST) Act of 2012 was introduced to the legislators in the United States to promote greater transparency in research industry. Public safety and advancement of science are the driving forces for the proposed policy change. The TEST Act may benefit the society and researchers; however, there are major concerns with participants' privacy and intellectual property protection. Copyright © 2014 Elsevier Inc. All rights reserved.

Ongoing EEG phase as a trial-by-trial predictor of perceptual and attentional variability

Directory of Open Access Journals (Sweden)

Rufin eVanRullen

2011-04-01

Full Text Available Even in well-controlled laboratory environments, apparently identical repetitions of an experimental trial can give rise to highly variable perceptual outcomes and behavioral responses. This variability is generally discarded as a reflection of intrinsic noise in neuronal systems. However, part of this variability may be accounted for by trial-by-trial fluctuations of the phase of ongoing oscillations at the moment of stimulus presentation. For example, the phase of an EEG oscillation reflecting the rapid waxing and waning of sustained attention can predict the perception of a subsequent visual stimulus at threshold. Similar ongoing periodicities account for a portion of the trial-by-trial variability of visual reaction times. We review the available experimental evidence linking ongoing EEG phase to perceptual and attentional variability, and the corresponding methodology. We propose future tests of this relation, and discuss the theoretical implications for understanding the neuronal dynamics of sensory perception.

Barriers towards the publication of academic drug trials. Follow-up of trials approved by the Danish Medicines Agency

DEFF Research Database (Denmark)

Berendt, Louise; Petersen, Lene Grejs; Bach, Karin Friis

2017-01-01

OBJECTIVE: To characterize and quantify barriers towards the publication of academic drug trials. STUDY DESIGN: We identified academic drug trials approved during a 3-year period (2004-2007) by the Danish Medicines Agency. We conducted a survey among the trial sponsors to describe the rates...... of initiation, completion, and publication, and the reasons for the failure to reach each of these milestones. Information on size and methodological characteristics of the trials was extracted from the EudraCT database, a prospective register of all approved clinical drug trials submitted to European medicines...... agencies since 2004. RESULTS: A total of 181 academic drug trials were eligible for inclusion, 139 of which participated in our survey (response rate: 77%). Follow-up time ranged from 5.1 to 7.9 years. Most trials were randomized controlled trials (73%, 95% CI 65-81%). Initiation and completion rates were...

OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis.

Science.gov (United States)

Hunter, D J; Arden, N; Cicuttini, F; Crema, M D; Dardzinski, B; Duryea, J; Guermazi, A; Haugen, I K; Kloppenburg, M; Maheu, E; Miller, C G; Martel-Pelletier, J; Ochoa-Albíztegui, R E; Pelletier, J-P; Peterfy, C; Roemer, F; Gold, G E

2015-05-01

Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Pragmatic trial design elements showed a different impact on trial interpretation and feasibility than explanatory elements

NARCIS (Netherlands)

Nieuwenhuis, Joost B.; Irving, Elaine; Oude Rengerink, Katrien; Lloyd, Emily; Goetz, Iris; Grobbee, Diederick E.; Stolk, Pieter; Groenwold, Rolf H H; Zuidgeest, Mira G P

2016-01-01

OBJECTIVE: To illustrate how pragmatic trial design elements, or inserting explanatory trial elements in pragmatic trials affect validity, generalizability, precision and operational feasibility. STUDY DESIGN AND SETTING: From illustrative examples identified through the IMI Get Real Consortium, we

OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis.

Science.gov (United States)

Kloppenburg, M; Maheu, E; Kraus, V B; Cicuttini, F; Doherty, M; Dreiser, R-L; Henrotin, Y; Jiang, G-L; Mandl, L; Martel-Pelletier, J; Nelson, A E; Neogi, T; Pelletier, J-P; Punzi, L; Ramonda, R; Simon, L S; Wang, S

2015-05-01

Hand osteoarthritis (OA) is a very frequent disease, but yet understudied. However, a lot of works have been published in the past 10 years, and much has been done to better understand its clinical course and structural progression. Despite this new knowledge, few therapeutic trials have been conducted in hand OA. The last OARSI recommendations for the conduct of clinical trials in hand OA dates back to 2006. The present recommendations aimed at updating previous recommendations, by incorporating new data. The purpose of this expert opinion, consensus driven exercise is to provide evidence-based guidance on the design, execution and analysis of clinical trials in hand OA, where published evidence is available, supplemented by expert opinion, where evidence is lacking, to perform clinical trials in hand OA, both for symptom and for structure-modification. They indicate core outcome measurement sets for studies in hand OA, and list the methods and instruments that should be used to measure symptoms or structure. For both symptom- and structure-modification, at least pain, physical function, patient global assessment, HR-QoL, joint activity and hand strength should be assessed. In addition, for structure-modification trials, structural progression should be measured by radiographic changes. We also provide a research agenda listing many unsolved issues that seem to most urgently need to be addressed from the perspective of performing "good" clinical trials in hand OA. These updated OARSI recommendations should allow for better standardizing the conduct of clinical trials in hand OA in the next future. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Hepatitis C: Clinical Trials

Science.gov (United States)

... and Public Home » Hepatitis C » Treatment Decisions Viral Hepatitis Menu Menu Viral Hepatitis Viral Hepatitis Home For ... can I find out about participating in a hepatitis C clinical trial? Many trials are being conducted ...

Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda

Directory of Open Access Journals (Sweden)

Agnes Ssali

2017-09-01

Full Text Available Introduction: The reasons why research participants join clinical trials remains an area of inquiry especially in low and middle income countries. Methods: We conducted exit interviews with participants who took part in a trial which aimed to evaluate whether long term prophylaxis with cotrimoxazole can be safely discontinued among adults who have been stabilised on antiretroviral therapy (ART. Participants were all reported to be stable on ART and had been participating in the trial for between 12 and 36 months; at the end of the trial participants were interviewed using a semi-structured questionnaire. One of the objectives of the exit interview was to find out what motivated the participants to join the research. Results: Participants gave personal reasons for joining the trial, frequently linked to their health and well-being as well as reduction of pill burden. Conclusion: We conclude that underlying reasons for joining clinical trials may extend beyond or can be different from the rationale given to the participants before enrolment by the research team. The reasons that motivate enrolment to clinical trials and research in general require further investigation in different settings. Trial registration number: ISRCTN44723643. Keywords: Randomised clinical trials, Volunteers, Participants

OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.

Science.gov (United States)

Kraus, V B; Blanco, F J; Englund, M; Henrotin, Y; Lohmander, L S; Losina, E; Önnerfjord, P; Persiani, S

2015-05-01

The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward OA-related biomarker qualification. The Guidelines for Biomarkers Working Group, representing experts in the field of OA biomarker research from both academia and industry, convened to discuss issues related to soluble biomarkers and to make recommendations for their use in OA clinical trials based on current knowledge and anticipated benefits. This document summarizes current guidance on use of biomarkers in OA clinical trials and their utility at five stages, including preclinical development and phase I to phase IV trials. As demonstrated by this summary, biomarkers can provide value at all stages of therapeutics development. When resources permit, we recommend collection of biospecimens in all OA clinical trials for a wide variety of reasons but in particular, to determine whether biomarkers are useful in identifying those individuals most likely to receive clinically important benefits from an intervention; and to determine whether biomarkers are useful for identifying individuals at earlier stages of OA in order to institute treatment at a time more amenable to disease modification. Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Assessing the readability of ClinicalTrials.gov.

Science.gov (United States)

Wu, Danny T Y; Hanauer, David A; Mei, Qiaozhu; Clark, Patricia M; An, Lawrence C; Proulx, Joshua; Zeng, Qing T; Vydiswaran, V G Vinod; Collins-Thompson, Kevyn; Zheng, Kai

2016-03-01

ClinicalTrials.gov serves critical functions of disseminating trial information to the public and helping the trials recruit participants. This study assessed the readability of trial descriptions at ClinicalTrials.gov using multiple quantitative measures. The analysis included all 165,988 trials registered at ClinicalTrials.gov as of April 30, 2014. To obtain benchmarks, the authors also analyzed 2 other medical corpora: (1) all 955 Health Topics articles from MedlinePlus and (2) a random sample of 100,000 clinician notes retrieved from an electronic health records system intended for conveying internal communication among medical professionals. The authors characterized each of the corpora using 4 surface metrics, and then applied 5 different scoring algorithms to assess their readability. The authors hypothesized that clinician notes would be most difficult to read, followed by trial descriptions and MedlinePlus Health Topics articles. Trial descriptions have the longest average sentence length (26.1 words) across all corpora; 65% of their words used are not covered by a basic medical English dictionary. In comparison, average sentence length of MedlinePlus Health Topics articles is 61% shorter, vocabulary size is 95% smaller, and dictionary coverage is 46% higher. All 5 scoring algorithms consistently rated CliniclTrials.gov trial descriptions the most difficult corpus to read, even harder than clinician notes. On average, it requires 18 years of education to properly understand these trial descriptions according to the results generated by the readability assessment algorithms. Trial descriptions at CliniclTrials.gov are extremely difficult to read. Significant work is warranted to improve their readability in order to achieve CliniclTrials.gov's goal of facilitating information dissemination and subject recruitment. Published by Oxford University Press on behalf of the American Medical Informatics Association 2015. This work is written by US Government

Spine device clinical trials: design and sponsorship.

Science.gov (United States)

Cher, Daniel J; Capobianco, Robyn A

2015-05-01

Multicenter prospective randomized clinical trials represent the best evidence to support the safety and effectiveness of medical devices. Industry sponsorship of multicenter clinical trials is purported to lead to bias. To determine what proportion of spine device-related trials are industry-sponsored and the effect of industry sponsorship on trial design. Analysis of data from a publicly available clinical trials database. Clinical trials of spine devices registered on ClinicalTrials.gov, a publicly accessible trial database, were evaluated in terms of design, number and location of study centers, and sample size. The relationship between trial design characteristics and study sponsorship was evaluated using logistic regression and general linear models. One thousand six hundred thrity-eight studies were retrieved from ClinicalTrials.gov using the search term "spine." Of the 367 trials that focused on spine surgery, 200 (54.5%) specifically studied devices for spine surgery and 167 (45.5%) focused on other issues related to spine surgery. Compared with nondevice trials, device trials were far more likely to be sponsored by the industry (74% vs. 22.2%, odds ratio (OR) 9.9 [95% confidence interval 6.1-16.3]). Industry-sponsored device trials were more likely multicenter (80% vs. 29%, OR 9.8 [4.8-21.1]) and had approximately four times as many participating study centers (pdevices not sponsored by the industry. Most device-related spine research is industry-sponsored. Multicenter trials are more likely to be industry-sponsored. These findings suggest that previously published studies showing larger effect sizes in industry-sponsored vs. nonindustry-sponsored studies may be biased as a result of failure to take into account the marked differences in design and purpose. Copyright © 2015 Elsevier Inc. All rights reserved.

Recruitment strategies and challenges in a large intervention trial: Systolic Blood Pressure Intervention Trial.

Science.gov (United States)

Ramsey, Thomas M; Snyder, Joni K; Lovato, Laura C; Roumie, Christianne L; Glasser, Steven P; Cosgrove, Nora M; Olney, Christine M; Tang, Rocky H; Johnson, Karen C; Still, Carolyn H; Gren, Lisa H; Childs, Jeffery C; Crago, Osa L; Summerson, John H; Walsh, Sandy M; Perdue, Letitia H; Bankowski, Denise M; Goff, David C

2016-06-01

The Systolic Blood Pressure Intervention Trial is a multicenter, randomized clinical trial of 9361 participants with hypertension who are ≥50 years old. The trial is designed to evaluate the effect of intensive systolic blood pressure control (systolic blood pressure goal recruitment strategies and lessons learned during recruitment of the Systolic Blood Pressure Intervention Trial cohort and five targeted participant subgroups: pre-existing cardiovascular disease, pre-existing chronic kidney disease, age ≥75 years, women, and minorities. In collaboration with the National Institutes of Health Project Office and Systolic Blood Pressure Intervention Trial Coordinating Center, five Clinical Center Networks oversaw clinical site selection, recruitment, and trial activities. Recruitment began on 8 November 2010 and ended on 15 March 2013 (about 28 months). Various recruitment strategies were used, including mass mailing, brochures, referrals from healthcare providers or friends, posters, newspaper ads, radio ads, and electronic medical record searches. Recruitment was scheduled to last 24 months to enroll a target of 9250 participants; in just over 28 months, the trial enrolled 9361 participants. The trial screened 14,692 volunteers, with 33% of initial screens originating from the use of mass mailing lists. Screening results show that participants also responded to recruitment efforts through referral by Systolic Blood Pressure Intervention Trial staff, healthcare providers, or friends (45%); brochures or posters placed in clinic waiting areas (15%); and television, radio, newspaper, Internet ads, or toll-free numbers (8%). The overall recruitment yield (number randomized/number screened) was 64% (9361 randomized/14,692 screened), 77% for those with cardiovascular disease, 79% for those with chronic kidney disease, 70% for those aged ≥75 years, 55% for women, and 61% for minorities. As recruitment was observed to lag behind expectations, additional

Medline Plus

Full Text Available ... Roosevelt Hospital, New York, NY, 1/04/2012) Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ... Center, Winston-Salem, NC, 09/17/2015) Seniors Coronary Artery Disease Transradial Approach for Cardiac Catheterization: The New Frontier ...

Medline Plus

Full Text Available ... Patient Quality-of-Life (Washington University School of Medicine in St. Louis, St. Louis, MO, 05/11/2011) Lungs and Breathing Lung Cancer Robotic-Assisted Surgery: Lung Resection (Wake Forest University Baptist Medical Center, Winston-Salem, NC, 2/ ...

Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative.

Science.gov (United States)

Greenberg, Rachel G; Corneli, Amy; Bradley, John; Farley, John; Jafri, Hasan S; Lin, Li; Nambiar, Sumathi; Noel, Gary J; Wheeler, Chris; Tiernan, Rosemary; Smith, P Brian; Roberts, Jamie; Benjamin, Daniel K

2018-03-01

Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to recruitment of pediatric patients, but little is known regarding the specific barriers that limit pediatric providers from participating in and referring their patients to clinical trials. We conducted an online survey of pediatric providers from a wide variety of practice types across the United States to evaluate their attitudes and awareness of pediatric clinical trials. Using a 4-point Likert scale, providers described their perception of potential barriers to their practice serving as a site for pediatric clinical trials. Of the 136 providers surveyed, 52/136 (38%) had previously referred a pediatric patient to a trial, and only 17/136 (12%) had ever been an investigator for a pediatric trial. Lack of awareness of existing pediatric trials was a major barrier to patient referral by providers, in addition to consideration of trial risks, distance to the site, and time needed to discuss trial participation with parents. Overall, providers perceived greater challenges related to parental concerns and parent or child logistical barriers than study implementation and ethics or regulatory barriers as barriers to their practice serving as a trial site. Providers who had previously been an investigator for a pediatric trial were less likely to be concerned with potential barriers than non-investigators. Understanding the barriers that limit pediatric providers from collaboration or inhibit their participation is key to designing effective interventions to optimize pediatric trial participation.

Design of Phase II Non-inferiority Trials.

Science.gov (United States)

Jung, Sin-Ho

2017-09-01

With the development of inexpensive treatment regimens and less invasive surgical procedures, we are confronted with non-inferiority study objectives. A non-inferiority phase III trial requires a roughly four times larger sample size than that of a similar standard superiority trial. Because of the large required sample size, we often face feasibility issues to open a non-inferiority trial. Furthermore, due to lack of phase II non-inferiority trial design methods, we do not have an opportunity to investigate the efficacy of the experimental therapy through a phase II trial. As a result, we often fail to open a non-inferiority phase III trial and a large number of non-inferiority clinical questions still remain unanswered. In this paper, we want to develop some designs for non-inferiority randomized phase II trials with feasible sample sizes. At first, we review a design method for non-inferiority phase III trials. Subsequently, we propose three different designs for non-inferiority phase II trials that can be used under different settings. Each method is demonstrated with examples. Each of the proposed design methods is shown to require a reasonable sample size for non-inferiority phase II trials. The three different non-inferiority phase II trial designs are used under different settings, but require similar sample sizes that are typical for phase II trials.

Strategies to improve retention in randomised trials

Science.gov (United States)

Brueton, Valerie C; Tierney, Jayne; Stenning, Sally; Harding, Seeromanie; Meredith, Sarah; Nazareth, Irwin; Rait, Greta

2013-01-01

Background Loss to follow-up from randomised trials can introduce bias and reduce study power, affecting the generalisability, validity and reliability of results. Many strategies are used to reduce loss to follow-up and improve retention but few have been formally evaluated. Objectives To quantify the effect of strategies to improve retention on the proportion of participants retained in randomised trials and to investigate if the effect varied by trial strategy and trial setting. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PreMEDLINE, EMBASE, PsycINFO, DARE, CINAHL, Campbell Collaboration's Social, Psychological, Educational and Criminological Trials Register, and ERIC. We handsearched conference proceedings and publication reference lists for eligible retention trials. We also surveyed all UK Clinical Trials Units to identify further studies. Selection criteria We included eligible retention trials of randomised or quasi-randomised evaluations of strategies to increase retention that were embedded in 'host' randomised trials from all disease areas and healthcare settings. We excluded studies aiming to increase treatment compliance. Data collection and analysis We contacted authors to supplement or confirm data that we had extracted. For retention trials, we recorded data on the method of randomisation, type of strategy evaluated, comparator, primary outcome, planned sample size, numbers randomised and numbers retained. We used risk ratios (RR) to evaluate the effectiveness of the addition of strategies to improve retention. We assessed heterogeneity between trials using the Chi2 and I2 statistics. For main trials that hosted retention trials, we extracted data on disease area, intervention, population, healthcare setting, sequence generation and allocation concealment. Main results We identified 38 eligible retention trials. Included trials evaluated six broad types of strategies to improve retention. These

Japan nuclear ship sea trial

International Nuclear Information System (INIS)

Yamazaki, Hiroshi; Kitamura, Toshikatus; Mizushima, Toshihiko

1992-01-01

The sea trial of the first Japan nuclear Ship 'MUTSU' was conducted from the end of October to December in 1990. The purpose of the sea trial was to verify the nuclear propulsive performances and maneuverabilities. The present report describes the results of the sea trial. These results are classified into four items: 1. Speed test and engineering performance tests 2. Maneuvering performance tests 3. Vibration tests 4. Other tests. Acceptable performances were demonstrated, as expected in the original design. The experience of the use of the Global Positioning System (GPS), which were newly adopted for the sea trial, is also reported. (author)

Modifying the Clinical Research Infrastructure at a Dedicated Clinical Trials Unit: Assessment of Trial Development, Activation, and Participant Accrual.

Science.gov (United States)

Tang, Chad; Hess, Kenneth R; Sanders, Dwana; Davis, Suzanne E; Buzdar, Aman U; Kurzrock, Razelle; Lee, J Jack; Meric-Bernstam, Funda; Hong, David S

2017-03-15

Purpose: Information on processes for trials assessing investigational therapeutics is sparse. We assessed the trial development processes within the Department of Investigational Cancer Therapeutics (ICT) at MD Anderson Cancer Center (Houston, TX) and analyzed their effects on the trial activation timeline and enrolment. Experimental Design: Data were from a prospectively maintained registry that tracks all clinical studies at MD Anderson. From this database, we identified 2,261 activated phase I-III trials; 221 were done at the ICT. ICT trials were matched to trials from other MD Anderson departments by phase, sponsorship, and submission year. Trial performance metrics were compared with paired Wilcoxon signed rank tests. Results: We identified three facets of the ICT research infrastructure: parallel processing of trial approval steps; a physician-led research team; and regular weekly meetings to foster research accountability. Separate analyses were conducted stratified by sponsorship [industry (133 ICT and 133 non-ICT trials) or institutional (68 ICT and 68 non-ICT trials)]. ICT trial development was faster from IRB approval to activation (median difference of 1.1 months for industry-sponsored trials vs. 2.3 months for institutional) and from activation to first enrolment (median difference of 0.3 months for industry vs. 1.2 months for institutional; all matched P infrastructure within a large academic cancer center was associated with efficient trial development and participant accrual. Clin Cancer Res; 23(6); 1407-13. ©2016 AACR . ©2016 American Association for Cancer Research.

Commentary: considerations for using the 'Trials within Cohorts' design in a clinical trial of an investigational medicinal product.

Science.gov (United States)

Bibby, Anna C; Torgerson, David J; Leach, Samantha; Lewis-White, Helen; Maskell, Nick A

2018-01-08

The 'trials within cohorts' (TwiC) design is a pragmatic approach to randomised trials in which trial participants are randomly selected from an existing cohort. The design has multiple potential benefits, including the option of conducting multiple trials within the same cohort. To date, the TwiC design methodology been used in numerous clinical settings but has never been applied to a clinical trial of an investigational medicinal product (CTIMP). We have recently secured the necessary approvals to undertake the first CTIMP using the TwiC design. In this paper, we describe some of the considerations and modifications required to ensure such a trial is compliant with Good Clinical Practice and international clinical trials regulations. We advocate using a two-stage consent process and using the consent stages to explicitly differentiate between trial participants and cohort participants who are providing control data. This distinction ensured compliance but had consequences with respect to costings, recruitment and the trial assessment schedule. We have demonstrated that it is possible to secure ethical and regulatory approval for a CTIMP TwiC. By including certain considerations at the trial design stage, we believe this pragmatic and efficient methodology could be utilised in other CTIMPs in future.

Production and preservation of platelet concentrates. Evaluation of elutruation technigue and advanced preservation technologies.

NARCIS (Netherlands)

Elias-Elias, Mona K.

1991-01-01

This thesis includes various studies on improving the collection and preservation of the platelet product, The conventional differential centrifugation method of platelet isolation, witch quantitatively is the common source of platelet supply, has several shortcomings. The technique depends solely

Quality Assurance for Clinical Trials

Science.gov (United States)

Ibbott, Geoffrey S.; Haworth, Annette; Followill, David S.

2013-01-01

Cooperative groups, of which the Radiation Therapy Oncology Group is one example, conduct national clinical trials that often involve the use of radiation therapy. In preparation for such a trial, the cooperative group prepares a protocol to define the goals of the trial, the rationale for its design, and the details of the treatment procedure to be followed. The Radiological Physics Center (RPC) is one of several quality assurance (QA) offices that is charged with assuring that participating institutions deliver doses that are clinically consistent and comparable. The RPC does this by conducting a variety of independent audits and credentialing processes. The RPC has compiled data showing that credentialing can help institutions comply with the requirements of a cooperative group clinical protocol. Phantom irradiations have been demonstrated to exercise an institution’s procedures for planning and delivering advanced external beam techniques (1–3). Similarly, RPC data indicate that a rapid review of patient treatment records or planning procedures can improve compliance with clinical trials (4). The experiences of the RPC are presented as examples of the contributions that a national clinical trials QA center can make to cooperative group trials. These experiences illustrate the critical need for comprehensive QA to assure that clinical trials are successful and cost-effective. The RPC is supported by grants CA 10953 and CA 81647 from the National Cancer Institute, NIH, DHHS. PMID:24392352

The Hyena: Witch's Auxiliary or Nature's Fool?

OpenAIRE

Dunham, Margaret

2006-01-01

Le texte publié sera accompagné des enregistrements sonores et de l'analyse interlinéaire de deux contes mettant en scène des hyènes.; Although the hyena cannot be considered a 'keystone' animal in Valangi culture, through its associations with witchcraft, it nevertheless holds an important place in the collective imagination and in the traditional folklore.; Bien que l'hyène ne puisse pas être considérée comme animal 'clé de voûte' dans la culture Valangi, elle tient néanmoins une place impo...

Trial-to-trial dynamics of selective long-term-memory retrieval with continuously changing retrieval targets.

Science.gov (United States)

Kizilirmak, Jasmin M; Rösler, Frank; Khader, Patrick H

2014-10-01

How do we control the successive retrieval of behaviorally relevant information from long-term memory (LTM) without being distracted by other potential retrieval targets associated to the same retrieval cues? Here, we approach this question by investigating the nature of trial-by-trial dynamics of selective LTM retrieval, i.e., in how far retrieval in one trial has detrimental or facilitatory effects on selective retrieval in the following trial. Participants first learned associations between retrieval cues and targets, with one cue always being linked to three targets, forming small associative networks. In successive trials, participants had to access either the same or a different target belonging to either the same or a different cue. We found that retrieval times were faster for targets that had already been relevant in the previous trial, with this facilitatory effect being substantially weaker when the associative network changed in which the targets were embedded. Moreover, staying within the same network still had a facilitatory effect even if the target changed, which became evident in a relatively higher memory performance in comparison to a network change. Furthermore, event-related brain potentials (ERPs) showed topographically and temporally dissociable correlates of these effects, suggesting that they result from combined influences of distinct processes that aid memory retrieval when relevant and irrelevant targets change their status from trial to trial. Taken together, the present study provides insight into the different processing stages of memory retrieval when fast switches between retrieval targets are required. Copyright © 2014 Elsevier Inc. All rights reserved.

Barriers towards the publication of academic drug trials. Follow-up of trials approved by the Danish Medicines Agency.

Science.gov (United States)

Berendt, Louise; Petersen, Lene Grejs; Bach, Karin Friis; Poulsen, Henrik Enghusen; Dalhoff, Kim

2017-01-01

To characterize and quantify barriers towards the publication of academic drug trials. We identified academic drug trials approved during a 3-year period (2004-2007) by the Danish Medicines Agency. We conducted a survey among the trial sponsors to describe the rates of initiation, completion, and publication, and the reasons for the failure to reach each of these milestones. Information on size and methodological characteristics of the trials was extracted from the EudraCT database, a prospective register of all approved clinical drug trials submitted to European medicines agencies since 2004. A total of 181 academic drug trials were eligible for inclusion, 139 of which participated in our survey (response rate: 77%). Follow-up time ranged from 5.1 to 7.9 years. Most trials were randomized controlled trials (73%, 95% CI 65-81%). Initiation and completion rates were 92% (95% CI: 88-97%) and 93% (95% CI: 89-97%) respectively. The publication rate of completed trials was 73% (95% CI: 62-79%). RCTs were published faster than non-RCTs (quartile time to publication 2.9 vs. 3.1 years, p = 0.0412). Many academic drug trials are left unpublished. Main barriers towards publication were related to the process from completion to publication. Hence, there is much to gain by facilitating the process from analysis to publication. Research institutions and funders should actively influence this process, e.g. by requiring the publication of trial results within a given time after completion.

[Lower Uterine Segment Trial: A pragmatic open multicenter randomized trial].

Science.gov (United States)

Rozenberg, P; Deruelle, P; Sénat, M-V; Desbrière, R; Winer, N; Simon, E; Ville, Y; Kayem, G; Boutron, I

2018-04-01

The data from literature show that trial of labor and elective repeat cesarean delivery after a prior cesarean delivery both present significant risks and benefits, and these risks and benefits differ for the woman and her fetus. The benefits to the woman can be at the expense of her fetus and vice-versa. This uncertainty is compounded by the scarcity of high-level evidence that preclude accurate quantification of the risks and benefits that could help provide a fair counseling about a trial of labor and elective repeat cesarean delivery. An interesting way of research is to evaluate the potential benefits of a decision rule associated to the ultrasound measurement of the lower uterine segment (LUS). Indeed, ultrasonography may be helpful in determining a specific risk for a given patient by measuring the thickness of the LUS, i,e, the thickness of the cesarean delivery scar area. Although only small and often methodologically biased data have been published, they look promising as their results are concordant: ultrasonographic measurements of the LUS thickness is highly correlated with the intraoperative findings at cesarean delivery. Furthermore, the thinner the LUS becomes on ultrasound, the higher the likelihood of a defect in the LUS. Finally, ultrasound assessment of LUS has an excellent negative predictive value for the risk of uterine defect. Therefore, this exam associated with a rule of decision could help to reduce the rate of elective repeat cesarean delivery and especially to reduce the fetal and maternal mortality and morbidity related to trial of labor after a prior cesarean delivery. This is a pragmatic open multicenter randomized trial with two parallel arms. Randomization will be centralized and computerized. Since blindness is impossible, an adjudication committee will evaluate the components of the primary composite outcome in order to avoid evaluation bias. An interim analysis will be planned mid-strength of the trial. Ultrasound will be

Microbicide clinical trial adherence: insights for introduction.

Science.gov (United States)

Woodsong, Cynthia; MacQueen, Kathleen; Amico, K Rivet; Friedland, Barbara; Gafos, Mitzy; Mansoor, Leila; Tolley, Elizabether; McCormack, Sheena

2013-04-08

After two decades of microbicide clinical trials it remains uncertain if vaginally- delivered products will be clearly shown to reduce the risk of HIV infection in women and girls. Furthermore, a microbicide product with demonstrated clinical efficacy must be used correctly and consistently if it is to prevent infection. Information on adherence that can be gleaned from microbicide trials is relevant for future microbicide safety and efficacy trials, pre-licensure implementation trials, Phase IV post-marketing research, and microbicide introduction and delivery. Drawing primarily from data and experience that has emerged from the large-scale microbicide efficacy trials completed to-date, the paper identifies six broad areas of adherence lessons learned: (1) Adherence measurement in clinical trials, (2) Comprehension of use instructions/Instructions for use, (3) Unknown efficacy and its effect on adherence/Messages regarding effectiveness, (4) Partner influence on use, (5) Retention and continuation and (6) Generalizability of trial participants' adherence behavior. Each is discussed, with examples provided from microbicide trials. For each of these adherence topics, recommendations are provided for using trial findings to prepare for future microbicide safety and efficacy trials, Phase IV post-marketing research, and microbicide introduction and delivery programs.

Massed Trials versus Trials Embedded into Game Play: Child Outcomes and Preference

Science.gov (United States)

Ledford, Jennifer R.; Chazin, Kate T.; Harbin, Emilee R.; Ward, Sarah E.

2017-01-01

Limited data are available regarding how response prompting procedures should be used in early childhood settings. The purpose of this study was to compare the efficiency of progressive time delay instruction presented via two trial arrangements: massed and embedded. During massed trial sessions, a short instructional session was conducted,…

Get-in-the-Zone (GITZ) Transition Display Format for Changing Camera Views in Multi-UAV Operations

Science.gov (United States)

2008-12-01

the multi-UAV operator will witch between dynamic and static missions, each potentially involving very different scenario environments and task...another. Inspired by cinematography techniques to help audiences maintain spatial understanding of a scene across discrete film cuts, use of a

Whistleblowing in a Wikileaks World: A Model for Responsible Disclosure in Homeland Security

Science.gov (United States)

2012-03-01

Historically, significant support for whistleblowers has occurred within Congress and the public. Popular culture has seen the success of films , such as...2010). Whistleblower witch hunts: The smokescreen syndrome. Washington, DC: Government Accountability Project. Devine, T. (2011, January 10). Who

impact of some climatic and phenological parameters on the ...

African Journals Online (AJOL)

Prof. Adipala Ekwamu

from cocoa and represent 30% of the working .... One of the ten best parents; very tolerant to witches' broom disease, resistant to Phytophthora, pod rot ... were estimated by visual observation from a scale ..... In memory of Dr. Jeanne Andi Kohi.

Comparability of prostate trials

DEFF Research Database (Denmark)

Suciu, S; Sylvester, R; Iversen, P

1993-01-01

The present overview of advanced prostate cancer required the identification of randomized clinical trials studying the question of maximal androgen blockade versus the classic castration therapy. The heterogeneity of the trials concerned the type of castration (surgical or chemical) and the type...

Assessment of genetic diversity on a sample of cocoa accessions resistant to witches' broom disease based on RAPD and pedigree data Avaliação da diversidade genética em uma amostra de acessos de cacau resistentes à doença vassoura-de-bruxa, com base em dados de RAPD e pedigree

Directory of Open Access Journals (Sweden)

Ronaldo Carvalho dos Santos

2005-01-01

Full Text Available Genetic diversity in cocoa (Theobroma cacao L. has been assessed based on morphological and molecular markers for germplasm management and breeding purposes. Pedigree data is available in cocoa but it has not been used for assessing genetic relatedness. The geneitic diversity of 30 clonal cocoa accessions resistant to witche´ broom disease, from the CEPEC series, were studied on the basis of RAPD data and pedigree information. Twenty of these accessions descend from the TSA-644 clone, originated from a cross between the Upper Amazon germplasm called Scavina-6, the main source of resistance to witches' broom disease, and IMC-67. The ten remaining clones come from different sources including Amazon and Trinitario germplasm. RAPD data was collected using 16 primers and pedigree information was obtained from the International Cocoa Germplasm Database. Genetic similarities, genetic distances and coefficient of parentage were calculated using available software. Relatively low genetic diversity was observed in this germplasm set, probably because of great genetic relatedness amongst accessions studied and the poor representation of the germplasm. The TSA-644 descendants were more diverse than the other accessions used in the study. This might be due to the origin of the TSA clone, which was derived from highly divergent genotypes. Association between genetic similarities based on RAPD data and coefficient of parentage, based on pedigree data, was very low, probably due to the homogeneity of the breeding stocks and poor pedigree information. These findings are useful to cocoa breeders in planning crosses for the development of hybrid and clonal cultivars.A diversidade genética em cacau (Theobroma cacao L., embasada em dados morfológicos e em marcadores moleculares, tem sido avaliada com fins de manejo de germoplasma e uso no melhoramento genético. Dados de genealogia de cacau, embora disponíveis, não têm sido utilizados. Foi analisada a

The FOCUS trial

DEFF Research Database (Denmark)

Glenthøj, Louise B; Fagerlund, Birgitte; Randers, Lasse

2015-01-01

BACKGROUND: Cognitive deficits are a distinct feature among people at ultra-high risk (UHR) for psychosis and pose a barrier to functional recovery. Insufficient evidence exists on how to ameliorate these cognitive deficits in patients at UHR for psychosis and hence improve daily living and quality...... of life. The aim of the trial is to investigate whether cognitive remediation can improve cognitive and psychosocial function in patients at UHR for psychosis. METHODS: The FOCUS trial (Function and Overall Cognition in Ultra-high risk States) is a randomised, parallel group, observer-blinded clinical...... trial enrolling 126 patients meeting the standardised criteria of being at UHR for psychosis. Patients are recruited from psychiatric in- and outpatient facilities in the Copenhagen catchment area. Patients are randomised to one of the two treatment arms: cognitive remediation plus standard treatment...

Australasian Experience and Trials in Sentinel Lymph Node Biopsy: The RACS SNAC Trial

Directory of Open Access Journals (Sweden)

Owen A. Ung

2004-10-01

Conclusions: The SNAC trial is one of the fastest accruing clinical trials in Australasia. It is on track to determine whether differences in morbidity, with equivalent cancer-related outcomes, exist between SLNB and AC for women with early breast cancer.

A randomized controlled Alzheimer's disease prevention trial's evolution into an exposure trial: the PREADViSE Trial.

Science.gov (United States)

Kryscio, R J; Abner, E L; Schmitt, F A; Goodman, P J; Mendiondo, M; Caban-Holt, A; Dennis, B C; Mathews, M; Klein, E A; Crowley, J J

2013-01-01

To summarize the ongoing prevention of Alzheimer's disease (AD) by vitamin E and selenium (PREADViSE) trial as an ancillary study to SELECT (a large prostate cancer prevention trial) and to present the blinded results of the first year as an exposure study. PREADViSE was designed as a double blind randomized controlled trial (RCT). SELECT terminated after median of 5.5 years of exposure to supplements due to a futility analysis. Both trials then converted into an exposure study. In the randomized component PREADViSE enrolled 7,547 men age 62 or older (60 if African American). Once the trial terminated 4,246 of these men volunteered for the exposure study. Demographics were similar for both groups with exposure volunteers having baseline mean age 67.3 ± 5.2 years, 15.3 ± 2.4 years of education, 9.8% African Americans, and 22.0% reporting a family history of dementia. In the RCT men were randomly assigned to either daily doses of 400 IU of vitamin E or placebo and 200 µg of selenium or placebo using a 2x2 factorial structure. In the RCT, participants completed the memory impairment screen (MIS), and if they failed, underwent a longer screening (based on an expanded Consortium to Establish a Registry in AD [CERAD] battery). CERAD failure resulted in visits to their clinician for medical examination with records of these examinations forwarded to the PREADViSE center for further review. In the exposure study, men are contacted by telephone and complete the telephone version of the memory impairment screen (MIS-T) screen. If they fail the MIS-T, a modified telephone interview of cognitive status (TICS-M) exam is given. A failed TICS-M exam also leads to a visit to their clinician for an in-depth examination and forwarding of records for a centralized consensus diagnosis by expert clinicians. A subgroup of the men who pass the MIS-T also take the TICS-M exam for validation purposes. While this ancillary trial was open to all 427 SELECT clinical sites, only 130 (30

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences. OUARDA BENLOUNES. Articles written in Journal of Chemical Sciences. Volume 130 Issue 4 April 2018 pp 40. Oxidative Dehydrogenation (ODH) of Ethylbenzene with CO2 and N2O over Heteropolycompounds · SALEM CHEKNOUN SADIA MANSOURI OUARDA ...

Expanding the Role of Institutional Research at Small Private Universities: A Case Study in Enrollment Management Using Data Mining

Science.gov (United States)

Antons, Christopher M.; Maltz, Elliot N.

2006-01-01

This case study documents a successful application of data-mining techniques in enrollment management through a partnership between the admissions office, a business administration master's-degree program, and the institutional research office at Willamette University (Salem, Oregon). (Contains 1 table and 3 figures.)

Effect of lactic acid bacteria on the textural properties of an edible ...

African Journals Online (AJOL)

Rodrigo

2013-05-08

May 8, 2013 ... Dominguez-Lopez1, Leobardo Manuel Gómez-Oliván2 and Abdel-Fattah Z.M. Salem4,5*. 1Facultad de ..... Furthermore, Alvarez (2012) observed that a film with .... Ribeiro C, Antonio A, Vicente JA, Teixeira, Miranda C (2007).

Red light running camera assessment.

Science.gov (United States)

2011-04-01

In the 2004-2007 period, the Mission Street SE and 25th Street SE intersection in Salem, Oregon showed relatively few crashes attributable to red light running (RLR) but, since a high number of RLR violations were observed, the intersection was ident...

78 FR 45181 - Foreign-Trade Zone 230-Piedmont Triad Area, North Carolina, Authorization of Production Activity...

Science.gov (United States)

2013-07-26

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-31-2013] Foreign-Trade Zone 230--Piedmont Triad Area, North Carolina, Authorization of Production Activity, Oracle Flexible Packaging, Inc., (Foil-Backed Paperboard), Winston-Salem, North Carolina On March 25, 2013, the Piedmont Triad Partnership...

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Full Text Available ... Medical Center, Winston-Salem, NC, 2/28/2014) Male Reproductive System Circumcision Circumcision (Broward Health Coral Springs, Coral Springs, FL, 3/31/2014) Erectile Dysfunction Simultaneous Inflatable Penile Prosthesis (IPP) and Male Sling Placement: Aiding in a Faster Return to ...

The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure

DEFF Research Database (Denmark)

Sever, Peter S; Poulter, Neil R; Dahlof, Bjorn

2008-01-01

Aims To determine the cardiovascular benefits in those originally assigned atorvastatin in the Anglo-Scandinavian Cardiac Outcomes Trial-2.2 years after closure of the lipid-lowering arm of the trial (ASCOT-LLA). Methods and results The Blood Pressure Lowering Arm of the ASCOT trial (ASCOT......-BPLA) compared two different antihypertensive treatment strategies on cardiovascular outcomes. ASCOT-LLA was a double-blind placebo-controlled trial of atorvastatin in those enrolled into ASCOT-BPLA with total cholesterol concentrations at baseline of ... enrolled in ASCOT-BPLA and 10 305 were further assigned either atorvastatin, 10 mg, or placebo. ASCOT-LLA was stopped prematurely after a median 3.3 years follow-up because of substantial cardiovascular benefits in those assigned atorvastatin. Trial physicians were invited to offer atorvastatin to all...

Age-related differences in the neural correlates of trial-to-trial variations of reaction time

Directory of Open Access Journals (Sweden)

Nancy E. Adleman

2016-06-01

Full Text Available Intra-subject variation in reaction time (ISVRT is a developmentally-important phenomenon that decreases from childhood through young adulthood in parallel with the development of executive functions and networks. Prior work has shown a significant association between trial-by-trial variations in reaction time (RT and trial-by-trial variations in brain activity as measured by the blood-oxygenated level-dependent (BOLD response in functional magnetic resonance imaging (fMRI studies. It remains unclear, however, whether such “RT-BOLD” relationships vary with age. Here, we determined whether such trial-by-trial relationships vary with age in a cross-sectional design. We observed an association between age and RT-BOLD relationships in 11 clusters located in visual/occipital regions, frontal and parietal association cortex, precentral/postcentral gyrus, and thalamus. Some of these relationships were negative, reflecting increased BOLD associated with decreased RT, manifesting around the time of stimulus presentation and positive several seconds later. Critically for present purposes, all RT-BOLD relationships increased with age. Thus, RT-BOLD relationships may reflect robust, measurable changes in the brain-behavior relationship across development.

Internet trials: participant experiences and perspectives.

Science.gov (United States)

Mathieu, Erin; Barratt, Alexandra; Carter, Stacy M; Jamtvedt, Gro

2012-10-23

Use of the Internet to conduct randomised controlled trials is increasing, and provides potential to increase equity of access to medical research, increase the generalisability of trial results and decrease the costs involved in conducting large scale trials. Several studies have compared response rates, completeness of data, and reliability of surveys using the Internet and traditional methods, but very little is known about participants' attitudes towards Internet-based randomised trials or their experience of participating in an Internet-based trial. To obtain insights into the experiences and perspectives of participants in an Internet-based randomised controlled trial, their attitudes to the use of the Internet to conduct medical research, and their intentions regarding future participation in Internet research. All English speaking participants in a recently completed Internet randomised controlled trial were invited to participate in an online survey. 1246 invitations were emailed. 416 participants completed the survey between May and October 2009 (33% response rate). Reasons given for participating in the Internet RCT fell into 4 main areas: personal interest in the research question and outcome, ease of participation, an appreciation of the importance of research and altruistic reasons. Participants' comments and reflections on their experience of participating in a fully online trial were positive and less than half of participants would have participated in the trial had it been conducted using other means of data collection. However participants identified trade-offs between the benefits and downsides of participating in Internet-based trials. The main trade-off was between flexibility and convenience - a perceived benefit - and a lack connectedness and understanding - a perceived disadvantage. The other tradeoffs were in the areas of: ease or difficulty in use of the Internet; security, privacy and confidentiality issues; perceived benefits and

Clinical trials. A pending subject.

Science.gov (United States)

Gil-Extremera, B; Jiménez-López, P; Mediavilla-García, J D

2018-04-01

Clinical trials are essential tools for the progress of clinical medicine in its diagnostic and therapeutic aspects. Since the first trial in 1948, which related tobacco use with lung cancer, there have been more than 150,000 clinical trials to date in various areas (paediatrics, cardiology, oncology, endocrinology, etc.). This article highlights the importance for all physicians to participate, over the course of their professional career, in a clinical trial, due to the inherent benefits for patients, the progress of medicine and for curricular prestige. The authors have created a synthesis of their experience with clinical trials on hypertension, diabetes, dyslipidaemia and ischaemic heart disease over the course of almost 3 decades. Furthermore, a brief reference has been made to the characteristics of a phase I unit, as well as to a number of research studies currently underway. Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative

Directory of Open Access Journals (Sweden)

Rachel G. Greenberg

2018-03-01

Of the 136 providers surveyed, 52/136 (38% had previously referred a pediatric patient to a trial, and only 17/136 (12% had ever been an investigator for a pediatric trial. Lack of awareness of existing pediatric trials was a major barrier to patient referral by providers, in addition to consideration of trial risks, distance to the site, and time needed to discuss trial participation with parents. Overall, providers perceived greater challenges related to parental concerns and parent or child logistical barriers than study implementation and ethics or regulatory barriers as barriers to their practice serving as a trial site. Providers who had previously been an investigator for a pediatric trial were less likely to be concerned with potential barriers than non-investigators. Understanding the barriers that limit pediatric providers from collaboration or inhibit their participation is key to designing effective interventions to optimize pediatric trial participation.

Trial-to-trial reoptimization of motor behavior due to changes in task demands is limited.

Directory of Open Access Journals (Sweden)

Orban de Xivry J-J

Full Text Available Each task requires a specific motor behavior that is tuned to task demands. For instance, writing requires a lot of accuracy while clapping does not. It is known that the brain adjusts the motor behavior to different task demands as predicted by optimal control theory. In this study, the mechanism of this reoptimization process is investigated by varying the accuracy demands of a reaching task. In this task, the width of the reaching target (0.5 or 8 cm was varied either on a trial-to-trial basis (random schedule or in blocks (blocked schedule. On some trials, the hand of the subjects was clamped to a rectilinear trajectory that ended 2 cm on the left or right of the target center. The rejection of this perturbation largely varied with target width in the blocked schedule but not in the random schedule. That is, subjects exhibited different motor behavior in the different schedules despite identical accuracy demands. Therefore, while reoptimization has been considered immediate and automatic, the differences in motor behavior observed across schedules suggest that the reoptimization of the motor behavior is neither happening on a trial-by-trial basis nor obligatory. The absence of trial-to-trial mechanisms, the inability of the brain to adapt to two conflicting task demands and the existence of a switching cost are discussed as possible sources of the non-optimality of motor behavior during the random schedule.

ChroPac-Trial: Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for chronic pancreatitis. Trial protocol of a randomised controlled multicentre trial

Directory of Open Access Journals (Sweden)

Schlitt Hans

2010-04-01

Full Text Available Abstract Background A recently published systematic review indicated superiority of duodenum-preserving techniques when compared with pancreatoduodenectomy, for the treatment of patients with chronic pancreatitis in the head of the gland. A multicentre randomised trial to confirm these results is needed. Methods/Design ChroPac aims to investigate differences in quality of life, mortality and morbidity during 24 months after surgery (duodenum-preserving pancreatic head resection versus pancreatoduodenectomy in patients with chronic pancreatitis of the pancreatic head. ChroPac is a randomised, controlled, observer and patient blinded multicentre surgical trial with two parallel comparison groups. The primary outcome measure will be the average quality of life during 24 months after surgery. Statistical analysis is based on the intention-to-treat population. Analysis of covariance will be applied for the intervention group comparison adjusting for age, centre and quality of life before surgery. Level of significance is set at 5% (two-sided and sample size (n = 100 per group is determined to assure a power of 90%. Discussion The ChroPac trial will explore important outcomes from different perspectives (e.g. surgeon, patient, health care system. Its pragmatic approach promises high external validity allowing a comprehensive evaluation of the surgical strategy for treatment of patients with chronic pancreatitis. Trial registration Controlled-trials.com ISRCTN38973832

Community-led trials: Intervention co-design in a cluster randomised controlled trial.

Science.gov (United States)

Andersson, Neil

2017-05-30

In conventional randomised controlled trials (RCTs), researchers design the interventions. In the Camino Verde trial, each intervention community designed its own programmes to prevent dengue. Instead of fixed actions or menus of activities to choose from, the trial randomised clusters to a participatory research protocol that began with sharing and discussing evidence from a local survey, going on to local authorship of the action plan for vector control.Adding equitable stakeholder engagement to RCT infrastructure anchors the research culturally, making it more meaningful to stakeholders. Replicability in other conditions is straightforward, since all intervention clusters used the same engagement protocol to discuss and to mobilize for dengue prevention. The ethical codes associated with RCTs play out differently in community-led pragmatic trials, where communities essentially choose what they want to do. Several discussion groups in each intervention community produced multiple plans for prevention, recognising different time lines. Some chose fast turnarounds, like elimination of breeding sites, and some chose longer term actions like garbage disposal and improving water supplies.A big part of the skill set for community-led trials is being able to stand back and simply support communities in what they want to do and how they want to do it, something that does not come naturally to many vector control programs or to RCT researchers. Unexpected negative outcomes can come from the turbulence implicit in participatory research. One example was the gender dynamic in the Mexican arm of the Camino Verde trial. Strong involvement of women in dengue control activities seems to have discouraged men in settings where activity in public spaces or outside of the home would ordinarily be considered a "male competence".Community-led trials address the tension between one-size-fits-all programme interventions and local needs. Whatever the conventional wisdom about how

Community-led trials: Intervention co-design in a cluster randomised controlled trial

Directory of Open Access Journals (Sweden)

Neil Andersson

2017-05-01

Full Text Available Abstract In conventional randomised controlled trials (RCTs, researchers design the interventions. In the Camino Verde trial, each intervention community designed its own programmes to prevent dengue. Instead of fixed actions or menus of activities to choose from, the trial randomised clusters to a participatory research protocol that began with sharing and discussing evidence from a local survey, going on to local authorship of the action plan for vector control. Adding equitable stakeholder engagement to RCT infrastructure anchors the research culturally, making it more meaningful to stakeholders. Replicability in other conditions is straightforward, since all intervention clusters used the same engagement protocol to discuss and to mobilize for dengue prevention. The ethical codes associated with RCTs play out differently in community-led pragmatic trials, where communities essentially choose what they want to do. Several discussion groups in each intervention community produced multiple plans for prevention, recognising different time lines. Some chose fast turnarounds, like elimination of breeding sites, and some chose longer term actions like garbage disposal and improving water supplies. A big part of the skill set for community-led trials is being able to stand back and simply support communities in what they want to do and how they want to do it, something that does not come naturally to many vector control programs or to RCT researchers. Unexpected negative outcomes can come from the turbulence implicit in participatory research. One example was the gender dynamic in the Mexican arm of the Camino Verde trial. Strong involvement of women in dengue control activities seems to have discouraged men in settings where activity in public spaces or outside of the home would ordinarily be considered a “male competence”. Community-led trials address the tension between one-size-fits-all programme interventions and local needs. Whatever the

Geographic differences in heart failure trials.

Science.gov (United States)

Ferreira, João Pedro; Girerd, Nicolas; Rossignol, Patrick; Zannad, Faiez

2015-09-01

Randomized controlled trials (RCTs) are essential to develop advances in heart failure (HF). The need for increasing numbers of patients (without substantial cost increase) and generalization of results led to the disappearance of international boundaries in large RCTs. The significant geographic differences in patients' characteristics, outcomes, and, most importantly, treatment effect observed in HF trials have recently been highlighted. Whether the observed regional discrepancies in HF trials are due to trial-specific issues, patient heterogeneity, structural differences in countries, or a complex interaction between factors are the questions we propose to debate in this review. To do so, we will analyse and review data from HF trials conducted in different world regions, from heart failure with preserved ejection fraction (HF-PEF), heart failure with reduced ejection fraction (HF-REF), and acute heart failure (AHF). Finally, we will suggest objective and actionable measures in order to mitigate regional discrepancies in future trials, particularly in HF-PEF where prognostic modifying treatments are urgently needed and in which trials are more prone to selection bias, due to a larger patient heterogeneity. © 2015 The Authors European Journal of Heart Failure © 2015 European Society of Cardiology.

Cross-Over Clinical Trials?

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Latif Gachkar

2017-01-01

Full Text Available Abstract Cross-Over Clinical Trials in comparison with Parallel groups clinical trials have some advantages such as control of confounding variables, small sample size, and short time to implement the research project. But this type of research has few essential limitations that discusses in this monogram.

Trial sponsorship and self-reported conflicts of interest in breast cancer radiation therapy: An analysis of prospective clinical trials.

Science.gov (United States)

Leite, Elton T T; Moraes, Fabio Y; Marta, Gustavo N; Taunk, Neil K; Vieira, Marina T L; Hanna, Samir A; Silva, João Luis F; Carvalho, Heloisa A

2017-06-01

We aim to assess any association between study and self-reported conflict of interest (COI) or trial sponsorship in breast cancer radiation clinical trials. We searched PubMed for all clinical trials (CTs) published between 09/2004 and 09/2014 related to breast cancer. We included only radiotherapy CTs with primary clinical endpoints. We classified eligible trials according to the funding source, presence or absence of conflict of interest, study conclusion and impact factor (IF). 1,603 CTs were retrieved. 72 randomized clinical trials were included for analysis. For-profit (PO), not for profit organization (nPO), none and not reported sponsorship rates were 9/72 (12.5%), 35/72 (48.6%), 1/72 (1.4%), 27/72 (37.5%), respectively. Present, absent or not reported COI were found in 6/72 (8.3%), 43/72 (59.7%) and 23/72 (32%) of the CTs, respectively. Conclusion was positive, neutral and negative in 57/72 (79.1%), 9/72 (12.5%) and 6/72 (8.4%) of the trials, respectively. Positive conclusion was reported in 33/44 (75%) funded trials (PO and nPO) and 5/6 (83.3%) CTs with reported COI. On univariate analysis no association with funding source (P=0.178), COI (P=0.678) or trial region (P=0.567) and trial positive conclusion was found. Sponsored trials (HR 4.50, 95CI-0.1.23-16.53;P=0.0023) and positive trials (HR 4.78, 95CI- 1.16-19.63;P=0.030) were more likely to be published in higher impact factor journals in the multivariate analysis. nPO funding was reported in almost 50% of the evaluated CTs. No significant association between study conclusion and funding source, COI or trial region was identified. Sponsored trials and positive trials were more likely to be published in higher impact factor journals. Copyright © 2017 Elsevier Ltd. All rights reserved.

Do clinical trials conducted in India match its healthcare needs? An audit of the Clinical Trials Registry of India

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Mansi Chaturvedi

2017-01-01

Full Text Available Background: India continues to contribute disproportionately to the global burden of disease and public health research output from India is also known to be not commensurate with her healthcare needs. We carried out the present study to assess if clinical trials were in line with the health care needs of the country by auditing the clinical trials registry of India. Materials and Methods: All the clinical studies registered in CTRI between July 20, 2007 and December 31, 2015 were searched in the “Trial Search” section. The total number of studies, their phases of development, and therapeutic areas were assessed. Trials in each therapeutic area was compared with the disease burden (DALYs in that area taken from Global Health Estimates [2014] Summary Tables of the WHO. The number of trials conducted per state in India was also compared with the population of that state [Census 2011]. Results: A total of 6474 studies were registered of which 3325 (51.4% were clinical trials. The state of Maharashtra had the highest number trials [16.4%] followed by Karnataka ( 11.6% and Tamil Nadu (10%. Populous states like Uttar Pradesh (5.3% and Bihar (1.4% had far fewer trials. The largest number of trials was in the area of cancer (16.4%, followed by diabetes (12.1% and cardiovascular diseases (10.1%. Infectious and parasitic diseases had the highest DALYs (82,681 and ranked first in disease burden but accounted for only 5% of the total trials and ranked 7th according to number of trials. Cancer ranked first in the number of trials (16.4%, but ranked 6th based on DALYs. Conclusion: Clinical trials conducted in India are not in consonance with her health care needs. Strengthening the capacity for conducting trials in the populous states and the north-eastern part of the country is necessary to allow a more equitable selection of participants. The government should introduce policies to encourage new drug development in areas where needed the most.

Automated classification of eligibility criteria in clinical trials to facilitate patient-trial matching for specific patient populations.

Science.gov (United States)

Zhang, Kevin; Demner-Fushman, Dina

2017-07-01

To develop automated classification methods for eligibility criteria in ClinicalTrials.gov to facilitate patient-trial matching for specific populations such as persons living with HIV or pregnant women. We annotated 891 interventional cancer trials from ClinicalTrials.gov based on their eligibility for human immunodeficiency virus (HIV)-positive patients using their eligibility criteria. These annotations were used to develop classifiers based on regular expressions and machine learning (ML). After evaluating classification of cancer trials for eligibility of HIV-positive patients, we sought to evaluate the generalizability of our approach to more general diseases and conditions. We annotated the eligibility criteria for 1570 of the most recent interventional trials from ClinicalTrials.gov for HIV-positive and pregnancy eligibility, and the classifiers were retrained and reevaluated using these data. On the cancer-HIV dataset, the baseline regex model, the bag-of-words ML classifier, and the ML classifier with named entity recognition (NER) achieved macro-averaged F2 scores of 0.77, 0.87, and 0.87, respectively; the addition of NER did not result in a significant performance improvement. On the general dataset, ML + NER achieved macro-averaged F2 scores of 0.91 and 0.85 for HIV and pregnancy, respectively. The eligibility status of specific patient populations, such as persons living with HIV and pregnant women, for clinical trials is of interest to both patients and clinicians. We show that it is feasible to develop a high-performing, automated trial classification system for eligibility status that can be integrated into consumer-facing search engines as well as patient-trial matching systems. Published by Oxford University Press on behalf of the American Medical Informatics Association 2017. This work is written by US Government employees and is in the public domain in the US.

African Journal of Neurological Sciences - 2009 Vol. 28 No 1

African Journals Online (AJOL)

The need of histological confirmation for solitaries meningeal process witch are often misdiagnosed as benign meningiomas. Introduction. Leptomeningeal metastases are more frequently observed in patient with known neoplasm, because cancer patients are living longer and advance in diagnostic means. They represent ...

Self-Medication

African Journals Online (AJOL)

2012-09-19

Sep 19, 2012 ... Key words: Self-medication, hazards, pregnant women, Nigeria ... these substances range from protection from witches and witchcrafts, preventing ... is common among pregnant women in our environment. .... Although earlier studies have association self-medication with factors such as self-employment, ...

Teaching Tomorrow's Classics.

Science.gov (United States)

Tighe, Mary Ann; Avinger, Charles

1994-01-01

Describes young adult novels that may prove to be classics of the genre. Discusses "The "Chocolate War" by Robert Cormier, "The Outsiders" by S. E. Hinton, "The Witch of Blackbird Pond" by Elizabeth George Speare, and "On Fortune's Wheel" by Cynthia Voight. (HB)

New approaches to trials in glomerulonephritis.

Science.gov (United States)

Craig, Jonathan C; Tong, Allison; Strippoli, Giovanni F M

2017-01-01

Randomized controlled trials are required to reliably identify interventions to improve the outcomes for people with glomerulonephritis (GN). Unfortunately, although easier, observational studies are inherently unreliable even though the findings of both study designs agree most of the time. Currently there are ∼790 trials in GN, but suboptimal design and reporting, together with small sample sizes, mean that they may not be reliable for decision making. If the history is somewhat bleak, the future looks bright, with recent initiatives to improve the quality, size and relevance of clinical trials in nephrology, including greater patient engagement, trial networks, core outcome sets, registry-based trials and adaptive designs. Given the current state of the evidence informing the care of people with GN, disruptive technologies and pervasive culture change is required to ensure that the potential of trials to improve the health of people with this complex condition is to be realized. © The Author 2017. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

Internet trials: participant experiences and perspectives

Science.gov (United States)

2012-01-01

Background Use of the Internet to conduct randomised controlled trials is increasing, and provides potential to increase equity of access to medical research, increase the generalisability of trial results and decrease the costs involved in conducting large scale trials. Several studies have compared response rates, completeness of data, and reliability of surveys using the Internet and traditional methods, but very little is known about participants’ attitudes towards Internet-based randomised trials or their experience of participating in an Internet-based trial. Objective To obtain insights into the experiences and perspectives of participants in an Internet-based randomised controlled trial, their attitudes to the use of the Internet to conduct medical research, and their intentions regarding future participation in Internet research. Methods All English speaking participants in a recently completed Internet randomised controlled trial were invited to participate in an online survey. Results 1246 invitations were emailed. 416 participants completed the survey between May and October 2009 (33% response rate). Reasons given for participating in the Internet RCT fell into 4 main areas: personal interest in the research question and outcome, ease of participation, an appreciation of the importance of research and altruistic reasons. Participants’ comments and reflections on their experience of participating in a fully online trial were positive and less than half of participants would have participated in the trial had it been conducted using other means of data collection. However participants identified trade-offs between the benefits and downsides of participating in Internet-based trials. The main trade-off was between flexibility and convenience – a perceived benefit – and a lack connectedness and understanding – a perceived disadvantage. The other tradeoffs were in the areas of: ease or difficulty in use of the Internet; security, privacy and

Internet trials: participant experiences and perspectives

Directory of Open Access Journals (Sweden)

Mathieu Erin

2012-10-01

Full Text Available Abstract Background Use of the Internet to conduct randomised controlled trials is increasing, and provides potential to increase equity of access to medical research, increase the generalisability of trial results and decrease the costs involved in conducting large scale trials. Several studies have compared response rates, completeness of data, and reliability of surveys using the Internet and traditional methods, but very little is known about participants’ attitudes towards Internet-based randomised trials or their experience of participating in an Internet-based trial. Objective To obtain insights into the experiences and perspectives of participants in an Internet-based randomised controlled trial, their attitudes to the use of the Internet to conduct medical research, and their intentions regarding future participation in Internet research. Methods All English speaking participants in a recently completed Internet randomised controlled trial were invited to participate in an online survey. Results 1246 invitations were emailed. 416 participants completed the survey between May and October 2009 (33% response rate. Reasons given for participating in the Internet RCT fell into 4 main areas: personal interest in the research question and outcome, ease of participation, an appreciation of the importance of research and altruistic reasons. Participants’ comments and reflections on their experience of participating in a fully online trial were positive and less than half of participants would have participated in the trial had it been conducted using other means of data collection. However participants identified trade-offs between the benefits and downsides of participating in Internet-based trials. The main trade-off was between flexibility and convenience – a perceived benefit – and a lack connectedness and understanding – a perceived disadvantage. The other tradeoffs were in the areas of: ease or difficulty in use of the Internet

Solar distiller of pyramidal covering and isolation in composite material the Plaster base and EPS; Destilador solar de cobertura piramidal e isolamento em material composito a base de Gesso e EPS

Energy Technology Data Exchange (ETDEWEB)

Santos, R. D.; Ribeiro, F. A.; Mendes, J. U.; Lima, R. S.; Souza, L. G.; Abreu, R. F.

2008-07-01

To demonstrate then term viability calorific and economic of the material, compared to the others conventional distiller, here is presented a solar distiller os simple stage, with has as main differential characteristics the geometry of the covering and the material used to make its coating. the model built has an area of 0,25 m{sup 2} and pyramidal covering, witch allows the collection of the distillate water in the four faces, different of just two like is found in the conventional distiller, besides promote the absorption of the radiation because of its versatility about the positioning of the sun. Not despite, its built is favored for the low cost associated and the agility in the process because it is made with a mix of gypsum, EPS ground and water, witch also attributes to the distiller thermal properties more favorable to the process of distillation. (Author)

Terrorists on Trial: A Performative Perspective

NARCIS (Netherlands)

de Graaf, B.A.

On 30 March 2011, ICCT – The Hague organised an Expert Meeting entitled ‘Terrorism Trials as Theatre: A Performative Perspective’. The Expert Meeting applied a performative perspective to three well known and recent trials in different parts of the world: the trials against the Dutch Hofstad Group,

Egyptian Journal of Biochemistry and Molecular Biology - Vol 31, No ...

African Journals Online (AJOL)

Molecular evaluation of Glypican 3 gene expression in Egyptian patients with Hepatocellular carcinoma · EMAIL FULL TEXT EMAIL FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. SA El-Kafrawy, M El-Daly, T Salem, M Abdel-Hamid, MA Hola, IH El-Sayed, 159-172 ...

75 FR 4783 - Procurement List; Proposed Additions

Science.gov (United States)

2010-01-29

..., Winston-Salem, NC. LC Industries, 4500 Emperor Blvd., Durham, NC. Lions Services, Inc., 4600 North Tryon... for the Blind, 6918 Murray Street, Little Rock, AR. NPAs: National Industries for the Blind... Arkansas Lighthouse for the Blind, Little Rock, AR. Contracting Activity: Department of Homeland Security...

76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

Science.gov (United States)

2011-05-11

... Logistics Division, Including On-Site Leased Workers From Prologistix, Including Workers Whose Unemployment..., applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site leased workers from... workers employed at CEVA Freight, LLC, Dell Logistics Division, Winston-Salem, North Carolina who were...

76 FR 45301 - PSEG Nuclear LLC, Hope Creek Generating Station; Notice of Issuance of Renewed Facility Operating...

Science.gov (United States)

2011-07-28

... NUCLEAR REGULATORY COMMISSION Docket No. 50-354 [NRC-2009-0391] PSEG Nuclear LLC, Hope Creek... operator of the Hope Creek Generating Station (HCGS). Renewed Facility Operating License No. NPF- 57... Renewal of Nuclear Power Plants, Supplement 45, Regarding Hope Creek Generating Station and Salem Nuclear...

78 FR 61389 - Sanyo Solar of Oregon, LLC, Wafer Slicing and Quality Control Operations, Including On-Site...

Science.gov (United States)

2013-10-03

..., LLC, Wafer Slicing and Quality Control Operations, Including On-Site Leased Workers From Brown and... Quality Control Operations, Salem, Oregon, including on-site leased workers from Brown and Dunton, Inc... and included workers who supplied quality control and support functions. The company reports that...

Private Sector Adds to the Menu.

Science.gov (United States)

Donovan, Sharon

1997-01-01

Two school districts, Kennewick School District WA and Salem-Keizer School District OR, are leveraging their food service contractor's resources to establish work-based courses stressing sophisticated management, culinary, and life skills. Under these instructional partnerships, the contractor, cooperating with school officials, develops the…

78 FR 37118 - Approval and Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and...

Science.gov (United States)

2013-06-20

... the core maintenance area exists; c. alternative fuel vehicle programs to include compressed natural... Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and Winston-Salem Carbon Monoxide... (CO), showing continued attainment of the 8-hour CO national ambient air quality standard for the...

27 CFR 9.174 - Yadkin Valley.

Science.gov (United States)

2010-04-01

...”. (b) Approved maps. The appropriate maps for determining the boundaries of the Yadkin Valley...-Salem, N.C.; VA; Tenn. (1953, Limited Revision 1962), and, (2) Charlotte, North Carolina; South Carolina... North Carolina within Wilkes, Surry, Yadkin and portions of Stokes, Forsyth, Davidson, and Davie...

Terrorists on Trial: A Performative Perspective

Directory of Open Access Journals (Sweden)

Beatrice de Graaf

2011-03-01

Full Text Available On 30 March 2011, ICCT organised an Expert Meeting entitled “Terrorism Trials as Theatre: A Performative Perspective”. The Expert Meeting applied a performative perspective to three well known and recent trials in different parts of the world: the trials against the Dutch Hofstad Group, the Mumbai 2008 Terrorist Attack Trial and the Guantanamo Military Tribunals. As such, the Expert Meeting did not concentrate solely on the immediate judicial performance of the magistrates and/or the defence; instead, the trials were put in their wider sociological context, adopting notions of social drama and communication sciences. This Expert Meeting Paper is a further adaptation of the Discussion Paper that was used as basis for debate during the Meeting.

The optimal design of stepped wedge trials with equal allocation to sequences and a comparison to other trial designs.

Science.gov (United States)

Thompson, Jennifer A; Fielding, Katherine; Hargreaves, James; Copas, Andrew

2017-12-01

Background/Aims We sought to optimise the design of stepped wedge trials with an equal allocation of clusters to sequences and explored sample size comparisons with alternative trial designs. Methods We developed a new expression for the design effect for a stepped wedge trial, assuming that observations are equally correlated within clusters and an equal number of observations in each period between sequences switching to the intervention. We minimised the design effect with respect to (1) the fraction of observations before the first and after the final sequence switches (the periods with all clusters in the control or intervention condition, respectively) and (2) the number of sequences. We compared the design effect of this optimised stepped wedge trial to the design effects of a parallel cluster-randomised trial, a cluster-randomised trial with baseline observations, and a hybrid trial design (a mixture of cluster-randomised trial and stepped wedge trial) with the same total cluster size for all designs. Results We found that a stepped wedge trial with an equal allocation to sequences is optimised by obtaining all observations after the first sequence switches and before the final sequence switches to the intervention; this means that the first sequence remains in the control condition and the last sequence remains in the intervention condition for the duration of the trial. With this design, the optimal number of sequences is [Formula: see text], where [Formula: see text] is the cluster-mean correlation, [Formula: see text] is the intracluster correlation coefficient, and m is the total cluster size. The optimal number of sequences is small when the intracluster correlation coefficient and cluster size are small and large when the intracluster correlation coefficient or cluster size is large. A cluster-randomised trial remains more efficient than the optimised stepped wedge trial when the intracluster correlation coefficient or cluster size is small. A

Re-Engineering Alzheimer Clinical Trials: Global Alzheimer's Platform Network.

Science.gov (United States)

Cummings, J; Aisen, P; Barton, R; Bork, J; Doody, R; Dwyer, J; Egan, J C; Feldman, H; Lappin, D; Truyen, L; Salloway, S; Sperling, R; Vradenburg, G

2016-06-01

Alzheimer's disease (AD) drug development is costly, time-consuming, and inefficient. Trial site functions, trial design, and patient recruitment for trials all require improvement. The Global Alzheimer Platform (GAP) was initiated in response to these challenges. Four GAP work streams evolved in the US to address different trial challenges: 1) registry-to-cohort web-based recruitment; 2) clinical trial site activation and site network construction (GAP-NET); 3) adaptive proof-of-concept clinical trial design; and 4) finance and fund raising. GAP-NET proposes to establish a standardized network of continuously funded trial sites that are highly qualified to perform trials (with established clinical, biomarker, imaging capability; certified raters; sophisticated management system. GAP-NET will conduct trials for academic and biopharma industry partners using standardized instrument versions and administration. Collaboration with the Innovative Medicines Initiative (IMI) European Prevention of Alzheimer's Disease (EPAD) program, the Canadian Consortium on Neurodegeneration in Aging (CCNA) and other similar international initiatives will allow conduct of global trials. GAP-NET aims to increase trial efficiency and quality, decrease trial redundancy, accelerate cohort development and trial recruitment, and decrease trial costs. The value proposition for sites includes stable funding and uniform training and trial execution; the value to trial sponsors is decreased trial costs, reduced time to execute trials, and enhanced data quality. The value for patients and society is the more rapid availability of new treatments for AD.

Phenolic compounds, methylxanthines and antioxidant activity in cocoa mass and chocolates produced from "witch broom disease" resistant and non resistant cocoa cultivars Compostos fenólicos, metilxantinas e atividade antioxidante em massa de cacau e chocolates produzidos a partir de cultivares resistentes e não resistentes a "vassoura de bruxa"

Directory of Open Access Journals (Sweden)

Paula Bacelar Leite

2013-06-01

Full Text Available The "witch broom disease" caused by the fungus called Moniliophthora perniciosa is one of the most important cocoa diseases in Latin America, causing around 70% production reduction in the southern Bahia. In attempt to solve the problem, many cultivars resistant to the disease have been recommended to farmers. On the other hand, the chocolate flavour is composed by many compounds whose formation depends on the genetic background, environment where cocoa is grown and processing operations. Therefore, this work aimed at determining the monomeric phenolic compounds, methylxanthines and antioxidant activity of cocoa mass and dark chocolate from cocoa cultivars resistant to "witch broom disease" and non resistant to the disease. The total phenolic compounds in cocoa mass did not vary among cultivars with values ranging from 23.95mg g-1 to 25.03mg g-1. Chocolates made from non resistant cultivars showed higher total phenolic compounds (19.11mg g-1 than SR162 and PH16 with 16.08mg g-1 and 15.46mg g-1, respectively. Epicatechin had higher content than catechin and the levels of these two compounds were higher in SR162. There were significant differences among samples of cocoa mass analyzed for caffeine. Chocolate made from SR162 had the highest amount of monomeric compounds due to its high concentration of catechin and epicatechin. The chocolate sample with the highest antioxidant activity was the SR162, followed by non resistant blend and PH16, showing relationship between the antioxidant activity and monomeric phenolics content.A "vassoura bruxa" causada pelo fungo Moniliophthora perniciosa, é uma das doenças mais importantes do cacau na América Latina, provocando uma redução de cerca de 70% na produção das amêndoas na Bahia. Para tentar resolver o problema, muitos cultivares resistentes à enfermidade têm sido recomendados para os agricultores. Por outro lado, as características do chocolate são oriundas de várias substâncias, cuja forma

Trial Courts in the Judicial Process.

Science.gov (United States)

McKnight, R. Neal

1981-01-01

Describes a college course which examines the organizational and behavioral characteristics of trial courts in the American judicial process. A major course objective is to help students understand the trial court process as a political process by showing how trial court organizations are involved in the allocation of social values. (RM)

Review- Cancer: Some genetic considerations | Salem | Egyptian ...

African Journals Online (AJOL)

Malignant transformation of normal cells to cancer cells represents an enigmatic phenomenon because of the many ambiguous controversies embodied within most of its aspects. Within a clinical context, cancer, with very few exceptions, is a dreadful disease that ends lethally. Within a biological context, however, cancer is ...

Sarwat Salem | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

Two years later he moved to the Centre's Regional Office of East and Central Africa, where he served for 10 years before returning to the Cairo office. Sarwat has extensive finance, administrative, and management experience. He is a member of the Order of Chartered Professional Accountants of Quebec and he holds a ...

Witch-Hunting in Coahuila, 1748-51. “De Villa de villa, sin Dios ni Santa María”

Directory of Open Access Journals (Sweden)

Lara Semboloni

2004-10-01

Full Text Available By reviewing the myths of witchcraft and sorcery, this paper analyzes the actors and social practices in a frontier  town, the last bulwark  before  total  wilderness,  in  the  Northern state of Coahuila,  Mexico. The author  studies the process of Inquisition during  1748-1751, a period  when  people  were accused of and tried  for diabolic  activities. The trials reveal a tendency  to explain the  game of human  passions  within  an unknown reality —characterized  by   an   apparent   lack   of   logic   and   formal canons—  through supernatural activities  and  satanic  pacts  atributed to  women,  regardless  of social class. In  this  context, moral  —and  political—  authorities  tried  to  stop  promiscuity, and their actions were seen as a need and determination to control a very fluid social structure,  i.e., to establish norms  for the regulation of moral standards  and collective values.

Differences in Investigator-Initiated Trials between Japan and Other Countries: Analyses of Clinical Trials Sponsored by Academia and Government in the ClinicalTrials.gov Registry and in the Three Japanese Registries.

Directory of Open Access Journals (Sweden)

Tatsuya Ito

Full Text Available Following the amendment of the Pharmaceutical Affairs Law in Japan in 2003 researchers were permitted to begin investigator-initiated trials (IITs. In subsequent years, however, the number of IITs remained low. In other countries in Asia as well as in Europe, North America, and South Africa, the number of IITs has increased over the past decade. The differences in the characteristics of IITs between Japan and other countries are unknown. Some studies have analyzed the characteristics of all clinical trials according to registry databases, but there has been less research focusing on IITs.The purpose of this study is to analyze the characteristics of IITs in the ClinicalTrials.gov registry and in the three Japanese registries, to identify differences in IITs between Japan and other countries.Using Thomson Reuters Pharma™, trials sponsored by academia and government as IITs in 2010 and registered in ClinicalTrials.gov were identified. IITs from 2004 to 2012 in Japan were identified in the three Japanese registries: the University Hospital Medical Information Network Clinical Trials Registry, the Japan Pharmaceutical Information Center Clinical Trials Information, and the Japan Medical Association Center for Clinical Trials, Clinical Trials Registry. Characterization was made of the trial purposes, phases, participants, masking, arms, design, controls, and other data.New and revised IITs registered in ClinicalTrials.gov during 2010 averaged about 40% of all sponsor-identified trials. IITs were nearly all early-phase studies with small numbers of participants. A total of 56 Japanese IITs were found over a period of 8 years, and these were also almost nearly all early-phase studies with small numbers of participants.There appear to be no great differences between Japan and other countries in terms of characteristics of IITs. These results should prompt a new review of the IIT environment in Japan.

Likely country of origin in publications on randomised controlled trials and controlled clinical trials during the last 60 years

DEFF Research Database (Denmark)

Gluud, Christian; Nikolova, Dimitrinka

2007-01-01

The number of publications on clinical trials is unknown as well as the countries publishing most trial reports. To try to examine these questions we performed an ecological study.......The number of publications on clinical trials is unknown as well as the countries publishing most trial reports. To try to examine these questions we performed an ecological study....

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: protocol for a feasibility randomized pilot trial.

Science.gov (United States)

Johnstone, Jennie; Meade, Maureen; Marshall, John; Heyland, Daren K; Surette, Michael G; Bowdish, Dawn Me; Lauzier, Francois; Thebane, Lehana; Cook, Deborah J

2015-01-01

Probiotics are defined as live microorganisms that may confer health benefits when ingested. Meta-analysis of probiotic trials suggests a 25 % lower ventilator-associated pneumonia (VAP) and 18 % lower infection rates overall when administered to patients in the intensive care unit (ICU). However, prior trials are small, largely single center, and at high risk of bias. Before a large rigorous trial is launched, testing whether probiotics confer benefit, harm, or have no impact, a pilot trial is needed. The aim of the PROSPECT Pilot Trial is to determine the feasibility of performing a larger trial in mechanically ventilated critically ill patients investigating Lactobacillus rhamnosus GG. A priori, we determined that the feasibility of the larger trial would be based on timely recruitment, high protocol adherence, minimal contamination, and an acceptable VAP rate. Patients ≥18 years old in the ICU who are anticipated to receive mechanical ventilation for ≥72 hours will be included. Patients are excluded if they are at increased risk of probiotic-associated infection, have strict enteral medication contraindications, are pregnant, previously enrolled in a related trial, or are receiving palliative care. Following informed consent, patients are randomized in variable unspecified block sizes in a fixed 1:1 ratio, stratified by ICU, and medical, surgical, or trauma admitting diagnosis. Patients receive 1 × 10 10 colony forming units of L. rhamnosus GG (Culturelle, Locin Industries Ltd) or an identical placebo suspended in tap water administered twice daily via nasogastric tube in the ICU. Clinical and research staff, patients, and families are blinded. The primary outcomes for this pilot trial are the following: (1) recruitment success, (2) ≥90 % protocol adherence, (3) ≤5 % contamination, and (4) ~10 % VAP rate. Additional clinical outcomes are VAP, other infections, diarrhea (total, antibiotic associated, and Clostridium difficile), ICU and

Children enacting idioms of witchcraft and spirit possession as a response to trauma: therapeutically beneficial, and for whom?

NARCIS (Netherlands)

Reis, R.

2013-01-01

This article examines children’s enactment of spirit possession idioms and witchcraft in Africa including the meanings such idioms provide and the local healing resources they mobilize. Idioms of haunting spirits in Northern Uganda and witch-children elsewhere in Africa can be interpreted as

ARTICLES

African Journals Online (AJOL)

Campbell Murn

Traders identified the following traits ascribed to vulture remains: treatment of epilepsy, insanity, stroke, ease of delivery in women, spiritual protection against witches and witchcraft, evil spirits, good luck (during gambling, money doubling, competition, contest), to stimulate walking in infants, and to gain supernatural powers.

DVD. Kaimar Palts soovitab : "Narnia" / Kaimar Palts

Index Scriptorium Estoniae

Palts, Kaimar

2006-01-01

DVD mängufilmist "Narnia lood : lõvi, nõid ja riidekapp" ("Chronicles of Narnia : The Lion, the Witch and the Wardrobe") C.S. Lewise muinasjutu ainetel : režissöör Andrew Adamson : Ameerika Ühendriigid 2005. Ka filmi lisadest DVD-l

Pop / Mart Kuldkepp

Index Scriptorium Estoniae

Kuldkepp, Mart

2008-01-01

Heliplaatidest: James "Hey Ma", Kelder "Vikerkaar ja latimeeria", David Torn "Lars and the Real Girl. Music from the motion picture", Tanel Ruben "Kogutud rikkus", Neon Neon "Stainless Style", 3 Doors Down "3 Doors Down", Winston Tong "In a Manner Of Speaking (Best Of)", Witch "Paralyzed"

77 FR 47373 - New England Fishery Management Council; Public Meeting

Science.gov (United States)

2012-08-08

..., Southern New England/Mid-Atlantic yellowtail flounder, Georges Bank yellowtail flounder, witch flounder, plaice and Georges Bank/Gulf of Maine white hake. The committee may not develop all the recommendations... accessible to people with disabilities. Requests for sign language interpretation or other auxiliary aids...

Transparency of Outcome Reporting and Trial Registration of Randomized Controlled Trials Published in the Journal of Consulting and Clinical Psychology.

Science.gov (United States)

Azar, Marleine; Riehm, Kira E; McKay, Dean; Thombs, Brett D

2015-01-01

Confidence that randomized controlled trial (RCT) results accurately reflect intervention effectiveness depends on proper trial conduct and the accuracy and completeness of published trial reports. The Journal of Consulting and Clinical Psychology (JCCP) is the primary trials journal amongst American Psychological Association (APA) journals. The objectives of this study were to review RCTs recently published in JCCP to evaluate (1) adequacy of primary outcome analysis definitions; (2) registration status; and, (3) among registered trials, adequacy of outcome registrations. Additionally, we compared results from JCCP to findings from a recent study of top psychosomatic and behavioral medicine journals. Eligible RCTs were published in JCCP in 2013-2014. For each RCT, two investigators independently extracted data on (1) adequacy of outcome analysis definitions in the published report, (2) whether the RCT was registered prior to enrolling patients, and (3) adequacy of outcome registration. Of 70 RCTs reviewed, 12 (17.1%) adequately defined primary or secondary outcome analyses, whereas 58 (82.3%) had multiple primary outcome analyses without statistical adjustment or undefined outcome analyses. There were 39 (55.7%) registered trials. Only two trials registered prior to patient enrollment with a single primary outcome variable and time point of assessment. However, in one of the two trials, registered and published outcomes were discrepant. No studies were adequately registered as per Standard Protocol Items: Recommendation for Interventional Trials guidelines. Compared to psychosomatic and behavioral medicine journals, the proportion of published trials with adequate outcome analysis declarations was significantly lower in JCCP (17.1% versus 32.9%; p = 0.029). The proportion of registered trials in JCCP (55.7%) was comparable to behavioral medicine journals (52.6%; p = 0.709). The quality of published outcome analysis definitions and trial registrations in JCCP is

Transparency of Outcome Reporting and Trial Registration of Randomized Controlled Trials Published in the Journal of Consulting and Clinical Psychology.

Directory of Open Access Journals (Sweden)

Marleine Azar

Full Text Available Confidence that randomized controlled trial (RCT results accurately reflect intervention effectiveness depends on proper trial conduct and the accuracy and completeness of published trial reports. The Journal of Consulting and Clinical Psychology (JCCP is the primary trials journal amongst American Psychological Association (APA journals. The objectives of this study were to review RCTs recently published in JCCP to evaluate (1 adequacy of primary outcome analysis definitions; (2 registration status; and, (3 among registered trials, adequacy of outcome registrations. Additionally, we compared results from JCCP to findings from a recent study of top psychosomatic and behavioral medicine journals.Eligible RCTs were published in JCCP in 2013-2014. For each RCT, two investigators independently extracted data on (1 adequacy of outcome analysis definitions in the published report, (2 whether the RCT was registered prior to enrolling patients, and (3 adequacy of outcome registration.Of 70 RCTs reviewed, 12 (17.1% adequately defined primary or secondary outcome analyses, whereas 58 (82.3% had multiple primary outcome analyses without statistical adjustment or undefined outcome analyses. There were 39 (55.7% registered trials. Only two trials registered prior to patient enrollment with a single primary outcome variable and time point of assessment. However, in one of the two trials, registered and published outcomes were discrepant. No studies were adequately registered as per Standard Protocol Items: Recommendation for Interventional Trials guidelines. Compared to psychosomatic and behavioral medicine journals, the proportion of published trials with adequate outcome analysis declarations was significantly lower in JCCP (17.1% versus 32.9%; p = 0.029. The proportion of registered trials in JCCP (55.7% was comparable to behavioral medicine journals (52.6%; p = 0.709.The quality of published outcome analysis definitions and trial registrations in JCCP is

Problematic trial detection in ClinicalTrials.gov

NARCIS (Netherlands)

Hartgerink, C.H.J.; George, Stephen

2015-01-01

Clinical trials are crucial in determining the effectiveness of treatments and directly affect clinical and policy decisions. These decisions are undermined if the data are problematic due to data fabrication or other errors. Researchers have worked on developing statistical methods to detect

The CYTONOX trial

DEFF Research Database (Denmark)

Gade, Christina; Mikus, Gerd; Christensen, Hanne Rolighed

2016-01-01

INTRODUCTION: In Denmark, it is estimated that 3-5% of children are obese. Obesity is associated with pathophysiological alterations that may lead to alterations in the pharmacokinetics of drugs. In adults, obesity was found to influence important drug-metabolising enzyme pathways. The impact...... of obesity-related alterations on drug metabolism and its consequences for drug dosing remains largely unknown in both children and adults. An altered drug metabolism may contribute significantly to therapeutic failure or toxicity. The aim of this trial is to investigate the in vivo activity of CYP3A4, CYP2E......1 and CYP1A2 substrates in obese versus non-obese children. METHODS: The CYTONOX trial is an open-label explorative pharmacokinetic trial. We intend to include 50 obese and 50 non-obese children. The primary end points are: in vivo clearance of CYP3A4, CYP2E1 and CYP1A2 substrates, which...

Electronic Cigarette Trial and Use among Young Adults: Reasons for Trial and Cessation of Vaping

OpenAIRE

Lois Biener; Eunyoung Song; Erin L. Sutfin; John Spangler; Mark Wolfson

2015-01-01

This paper identifies predictors of trial and current use, and reasons for trying and ceasing use of electronic cigarettes (e-cigarettes) among young adults, with particular attention to former and never smokers. Data are from a mail survey of a population-based sample of adults aged 18 to 35 (N = 4740) in three U.S. metropolitan areas. Survey items assessed trial and use of e-cigarettes, cigarette smoking status, and reasons for trial and for ceasing use of e-cigarettes. Almost 23% reported ...

Characteristics of randomised trials on diseases in the digestive system registered in ClinicalTrials.gov: a retrospective analysis

DEFF Research Database (Denmark)

Wildt, Signe; Krag, Aleksander; Gluud, Liselotte

2011-01-01

Objectives To evaluate the adequacy of reporting of protocols for randomised trials on diseases of the digestive system registered in http://ClinicalTrials.gov and the consistency between primary outcomes, secondary outcomes and sample size specified in http://ClinicalTrials.gov and published...

Journal of Chemical Sciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Chemical Sciences; Volume 128; Issue 1 ... Ruthenium(II) complexes (1-3) bearing bis-phenolate--heterocyclic carbene ligand were synthesized in good yields by the reaction of imidazolinium proligand (HL) with ... Department of Chemistry, Periyar University, Salem 636 011, Tamil Nadu, India ...

ABCA1 C69T gene polymorphism and risk of type 2 diabetes ...

Indian Academy of Sciences (India)

ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi population. KHALID K ALHARBI, IMRAN ALI KHAN, NASSER M AL-DAGHRI, ANJANA MUNSHI, VANDANA SHARMA,. ABDUL KHADER MOHAMMED, KAISER A WANI, YAZEED A AL-SHEIK. MAY SALEM AL-NBAHEEN,. MOHAMMED ...

78 FR 67129 - Procurement List; Additions

Science.gov (United States)

2013-11-08

...: Products NSN: MR 377--Socks, Holiday. NSN: MR 382--Duct Tape, Holiday Themed, Assorted Colors. NSN: MR 10635--Serving Platter, Heavy Duty, Raised Surface, Fall Themed, White. NPA: Winston-Salem Industries... Requirement as aggregated by the General Services Administration. NSN: 6645-00-NIB-0142--Clock, Wall, Quartz...

77 FR 77016 - Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets...

Science.gov (United States)

2012-12-31

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-69-2012] Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets); Rural Hall and Winston-Salem, North Carolina On August 20, 2012, the Piedmont Triad Partnership, grantee of FTZ 230, submitted a notification of...

Single-Trial Inference on Visual Attention

DEFF Research Database (Denmark)

Dyrholm, Mads; Kyllingsbæk, Søren; Vangkilde, Signe Allerup

2011-01-01

In this paper we take a step towards single-trial behavioral modeling within a Theory of Visual Attention (TVA). In selective attention tasks, such as the Partial Report paradigm, the subject is asked to ignore distractors and only report stimuli that belong to the target class. Nothing about...... Report trial. This result retrodicts a latent attentional state of the subject using the observed response from that particular trial and thus differs from other predictions made with TVA which are based on expected values of observed variables. We show an example of the result in single-trial analysis...

The therapeutic effect of clinical trials: understanding placebo response rates in clinical trials – A secondary analysis

Directory of Open Access Journals (Sweden)

Walach Harald

2005-08-01

Full Text Available Abstract Background and purpose Placebo response rates in clinical trials vary considerably and are observed frequently. For new drugs it can be difficult to prove effectiveness superior to placebo. It is unclear what contributes to improvement in the placebo groups. We wanted to clarify, what elements of clinical trials determine placebo variability. Methods We analysed a representative sample of 141 published long-term trials (randomized, double-blind, placebo-controlled; duration > 12 weeks to find out what study characteristics predict placebo response rates in various diseases. Correlational and regression analyses with study characteristics and placebo response rates were carried out. Results We found a high and significant correlation between placebo and treatment response rate across diseases (r = .78; p Conclusion Medication response rates and placebo response rates in clinical trials are highly correlated. Trial characteristics can explain some portion of the variance in placebo healing rates in RCTs. Placebo response in trials is only partially due to methodological artefacts and only partially dependent on the diagnoses treated.

From randomised trials to rational practice.

Science.gov (United States)

van Gijn, J

2005-01-01

From the age of Enlightenment onwards, philosophical thinking has become increasingly influenced by empiricism: observations lead to theories, but experiments are needed to put the reasoning to the test. However, it was not until the middle of the 20th century that well-designed experiments were at last introduced in medical treatment, in the form of randomised controlled clinical trials. This design is now standard in medicine, but in everyday practice a multitude of management decisions must still be taken without good evidence. There are several reasons for this: there may not be a trial at all or only a single trial; trial results may be equivocal; patients may be different from those enrolled in trials; new procedures require practice, or a trial may not be feasible. 'Logical reasoning', with all its fallacies, is still required - not only to fill the gaps in empirical knowledge but also to interpret existing evidence and to plan new trials. In fact, the generation of new knowledge is a continuous, cyclical process in which newly gained insights in pathophysiology give rise to new therapeutic experiments, the results of which generate fresh hypotheses, and so on. Compassion, curiosity and doubt are the essential forces that keep the cycle moving. Conversely, the progress is slowed down by present-day legalism, which distorts investigator accountability and patient autonomy. Copyright (c) 2005 S. Karger AG, Basel.

Clinical Trials

Medline Plus

Full Text Available ... part. Randomization Most clinical trials that have comparison groups use randomization. This involves assigning patients to different comparison groups by chance, rather than choice. This ...

Participant recruitment and retention in longitudinal preconception randomized trials: lessons learnt from the Calcium And Pre-eclampsia (CAP) trial.

Science.gov (United States)

Lawrie, Theresa A; Betrán, Ana Pilar; Singata-Madliki, Mandisa; Ciganda, Alvaro; Hofmeyr, G Justus; Belizán, José M; Purnat, Tina Dannemann; Manyame, Sarah; Parker, Catherine; Cormick, Gabriela

2017-10-26

The preconception period has the potential to influence pregnancy outcomes and randomized controlled trials (RCTs) are needed to evaluate a variety of potentially beneficial preconception interventions. However, RCTs commencing before pregnancy have significant participant recruitment and retention challenges. The Calcium And Pre-eclampsia trial (CAP trial) is a World Health Organization multi-country RCT of calcium supplementation commenced before pregnancy to prevent recurrent pre-eclampsia in which non-pregnant participants are recruited and followed up until childbirth. This sub-study explores recruitment methods and preconception retention of participants of the CAP trial to inform future trials. Recruiters at the study sites in Argentina, South Africa and Zimbabwe completed post-recruitment phase questionnaires on recruitment methods used. Qualitative data from these questionnaires and quantitative data on pre-pregnancy trial visit attendance and pregnancy rates up to September 2016 are reported in this paper. RStudio (Version 0.99.903 https://www.rstudio.org ) statistical software was used for summary statistics. Between July 2011 and 8 September 2016, 1354 women with previous pre-eclampsia were recruited. Recruitment took 2 years longer than expected and was facilitated mainly through medical record/register and maternity ward/clinic-based strategies. Recruiters highlighted difficulties associated with inadequate medical records, redundant patient contact details, and follow-up of temporarily ineligible women as some of the challenges faced. Whilst the attendance rates at pre-pregnancy visits were high (78% or more), visits often occurred later than scheduled. Forty-five percent of participants became pregnant (614/1354), 33.5% (454/1354) within 1 year of randomization. In preconception trials, both retrospective and prospective methods are useful for recruiting eligible women with certain conditions. However, these are time-consuming in low

Traditional and new composite endpoints in heart failure clinical trials : facilitating comprehensive efficacy assessments and improving trial efficiency

NARCIS (Netherlands)

Anker, Stefan D. t; Schroeder, Stefan; Atar, Dan; Bax, Jeroen J.; Ceconi, Claudio; Cowie, Martin R.; AdamCrisp,; Dominjon, Fabienne; Ford, Ian; Ghofrani, Hossein-Ardeschir; Gropper, Savion; Hindricks, Gerhard; Hlatky, Mark A.; Holcomb, Richard; Honarpour, Narimon; Jukema, J. Wouter; Kim, Albert M.; Kunz, Michael; Lefkowitz, Martin; Le Floch, Chantal; Landmesser, Ulf; McDonagh, Theresa A.; McMurray, John J.; Merkely, Bela; Packer, Milton; Prasad, Krishna; Revkin, James; Rosano, Giuseppe M. C.; Somaratne, Ransi; Stough, Wendy Gattis; Voors, Adriaan A.; Ruschitzka, Frank

Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of patients to accrue a sufficient number of outcome events and

Is Mandatory Prospective Trial Registration Working to Prevent Publication of Unregistered Trials and Selective Outcome Reporting? An Observational Study of Five Psychiatry Journals That Mandate Prospective Clinical Trial Registration.

Directory of Open Access Journals (Sweden)

Amelia Scott

Full Text Available To address the bias occurring in the medical literature associated with selective outcome reporting, in 2005, the International Committee of Medical Journal Editors (ICMJE introduced mandatory trial registration guidelines and member journals required prospective registration of trials prior to patient enrolment as a condition of publication. No research has examined whether these guidelines are impacting psychiatry publications. Our objectives were to determine the extent to which articles published in psychiatry journals adhering to ICMJE guidelines were correctly prospectively registered, whether there was evidence of selective outcome reporting and changes to participant numbers, and whether there was a relationship between registration status and source of funding.Any clinical trial (as defined by ICMJE published between 1 January 2009 and 31 July 2013 in the top five psychiatry journals adhering to ICMJE guidelines (The American Journal of Psychiatry, Archives of General Psychiatry/JAMA Psychiatry, Biological Psychiatry, Journal of the American Academy of Child and Adolescent Psychiatry, and The Journal of Clinical Psychiatry and conducted after July 2005 (or 2007 for two journals was included. For each identified trial, where possible we extracted trial registration information, changes to POMs between publication and registry to assess selective outcome reporting, changes to participant numbers, and funding type.Out of 3305 articles, 181 studies were identified as clinical trials requiring registration: 21 (11.6% were deemed unregistered, 61 (33.7% were retrospectively registered, 37 (20.4% had unclear POMs either in the article or the registry and 2 (1.1% were registered in an inaccessible trial registry. Only 60 (33.1% studies were prospectively registered with clearly defined POMs; 17 of these 60 (28.3% showed evidence of selective outcome reporting and 16 (26.7% demonstrated a change in participant numbers of 20% or more; only 26 (14

Clinical Trials

Medline Plus

Full Text Available ... or treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight for clinical trials that ...

Clinical Trials

Medline Plus

Full Text Available ... treatment is having harmful effects. Food and Drug Administration In the United States, the Food and Drug Administration (FDA) provides oversight for clinical trials that are ...

Transparency in ovarian cancer clinical trial results: ClinicalTrials.gov versus PubMed, Embase and Google scholar.

Science.gov (United States)

Roberto, Anna; Radrezza, Silvia; Mosconi, Paola

2018-04-10

In recent years the question of the lack of transparency in clinical research has been debated by clinicians, researchers, citizens and their representatives, authors and publishers. This is particularly important for infrequent cancers such as ovarian cancer, where treatment still gives disappointing results in the majority of cases. Our aim was to assess the availability to the public of results in ClinicalTrials.gov, and the frequency of non-publication of results in ClinicalTrials.gov and in PubMed, Embase and Google Scholar. We collected all trials on ovarian cancer identified as "completed status" in the ClinicalTrials.gov registry on 17 January 2017. We checked the availability of the results in ClinicalTrials.gov and systematically identified published manuscripts on results. Out of 2725 trials on ovarian cancer identified, 752 were classified as "completed status". In those closed between 2008 and 2015, excluding phase I, the frequency of results in ClinicalTrials.gov was 35%. Of the 752 completed studies the frequency of published results in PubMed, Embase or Google Scholar ranged from 57.9% to 69.7% in the last years. These findings show a lack of transparency and credibility of research. Citizens or patients' representatives, with the medical community, should continuously support initiatives to improve the publication and dissemination of clinical study results.

Influence of trial design, heterogeneity and regulatory environment on the results of clinical trials: An appraisal in the context of recent trials on acute stroke intervention

Directory of Open Access Journals (Sweden)

P R Srijithesh

2014-01-01

Full Text Available The outcome of randomized controlled trials can vary depending on the eligibility criteria of the patients entering into the trial, as well as the heterogeneity of the eligible population and/or the interventions. If the subject population and/or interventions are heterogeneous, the final outcome of the trial depends on the degree of concordance of effects of the subgroups of interventions on the subgroups of the subject population. The considerations that go into the calculation of sample size and determination of the study stopping rules also would affect the nature of the outcome of the study. In this paper we try to examine these phenomena with respect to the recent trials on endovascular therapy in acute ischemic stroke.

Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer

International Nuclear Information System (INIS)

Zakeri, Kaveh; Rose, Brent S.; D’Amico, Anthony V.; Jeong, Jong-Hyeon; Mell, Loren K.

2015-01-01

Background: Clinical trial costs may be reduced by identifying enriched subpopulations of patients with favorable risk profiles for the events of interest. However, increased selectivity affects accrual rates, with uncertain impact on clinical trial cost. Methods: We conducted a secondary analysis of Southwest Oncology Group (SWOG) 8794 randomized trial of adjuvant radiotherapy for high-risk prostate cancer. The primary endpoint was metastasis-free survival (MFS), defined as time to metastasis or death from any cause (competing mortality). We used competing risks regression models to identify an enriched subgroup at high risk for metastasis and low risk for competing mortality. We applied a cost model to estimate the impact of enrichment on trial cost and duration. Results: The treatment effect on metastasis was similar in the enriched subgroup (HR, 0.42; 95% CI, 0.23–0.76) compared to the whole cohort (HR, 0.50; 95% CI, 0.30–0.81) while the effect on competing mortality was not significant in the subgroup or the whole cohort (HR 0.70; 95% CI 0.39–1.23, vs. HR 0.94; 95% CI, 0.68–1.31). Due to the higher incidence of metastasis relative to competing mortality in the enriched subgroup, the treatment effect on MFS was greater in the subgroup compared to the whole cohort (HR 0.55; 95% CI 0.36–0.82, vs. HR 0.77; 95% CI, 0.58–1.01). Trial cost was 75% less in the subgroup compared to the whole cohort ($1.7 million vs. $6.8 million), and the trial duration was 30% shorter (8.4 vs. 12.0 years). Conclusion: Competing event enrichment can reduce clinical trial cost and duration, without sacrificing generalizability