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Porta, Emilio; Klein, Jennifer; Arcia, Gustavo; Nannyonjo, Harriet
The Education Management Information System (EMIS) in St. Kitts and Nevis is part of the Education Planning Division of the Ministry of Education. It functions in collaboration with the Chief Education Officer and other education officers. Four key objectives of St. Kitts EMIS have been established: collect and analyze educational data; inform policymakers; provide feedback to stakeholders...
Mohammed, Hamish; Evanson, Jessica; Revan, Floyd; Lee, Elise; Krecek, Rosina C; Smith, Joshua
Adult mosquito surveys of Saint Kitts and Nevis (SKN) were performed in the dry season (March 16-23, 2010) in Saint Kitts, and the rainy season (October 18-25, 2010) in SKN. Biogents (BG) Sentinel Traps were set with CO₂and BG Lure in urban, rural, mangrove, and dry forest habitats. Mosquitoes were identified to species, and reverse transcription-polymerase chain reaction was performed on potential vector species for dengue virus (DENV), chikungunya virus (CHIKV), and West Nile virus (WNV). The most abundant species during both seasons in St. Kitts were Culex quinquefasciatus, Aedes taeniorhynchus, and Aedes aegypti. There were 3 new records for Saint Kitts: Aedes tortilis, Anopheles albimanus, and Culex nigripalpus. Traps were also set in Nevis. No mosquito pool tested positive for DENV, CHIKV, or WNV.
St. Kitts and Nevis have areas of 68 and 36 square miles respectively and the terrain is mountainous. The population is 45,800 total and the annual growth rate is .2%. The ethnic make up is almost all black African with some British, Portuguese, and Lebanese. The religions are primarily Anglican, with evangelical Protestant and Catholic minorities. Infant mortality stands at 41/1000. The government is a constitutional monarchy with a Westminster type parliament. There is a governor, a prime minister, a cabinet, an 11 -member appointed upper house and a 11- member elected house of representatives. The gross national product is $83 million and the annual growth rate is 4.6%. There are no natural resources, and agricultural products include sugarcane, cotton, peanuts, and vegetables. Industry is made up of manufacturing 12.9%, transport and communications 13%, construction 9.1% and hotels and restaurants 4.5%. The Federation of St. Kitts and Nevis became independent in 1983. The government diversified the agriculture by planting other crops than sugar, producing gelled ethanol, and developing a cane spirits liquor. Tourism has grown the most and in 1987 passed sugar as the main source of income. International aid will assist in finishing a road that will open the southeast area of St. Kitts for construction of hotels, where some of the best beaches are located.
Crews, Deidra C; Campbell, Kirk N; Liu, Yang; Bussue, Odell; Dawkins, Ingrid; Young, Bessie A.
Background The prevalence of chronic kidney disease (CKD) in St. Kitts and Nevis, islands of the West Indies, is unknown. We sought to determine estimates of CKD and its risk factors (e.g. diabetes, hypertension and obesity) in St. Kitts and Nevis. Methods This was a chronic disease screening program. Three community-based locations in St. Kitts and Nevis were included in the program. Participants were adult community residents aged ?18?years. The main outcome measures were estimated CKD prev...
Despite high levels of per capita incomes and good social service provision, poverty remains a persistent problem in St. Kitts and Nevis. To improve competitiveness, restore rapid economic growth, and ensure its medium-term sustainability in the context of the currency union, the main challenges to the St. Kitts and Nevis government are to (a) tighten fiscal policy, notably through expendi...
Crews, Deidra C; Campbell, Kirk N; Liu, Yang; Bussue, Odell; Dawkins, Ingrid; Young, Bessie A
The prevalence of chronic kidney disease (CKD) in St. Kitts and Nevis, islands of the West Indies, is unknown. We sought to determine estimates of CKD and its risk factors (e.g. diabetes, hypertension and obesity) in St. Kitts and Nevis. This was a chronic disease screening program. Three community-based locations in St. Kitts and Nevis were included in the program. Participants were adult community residents aged ≥18 years. The main outcome measures were estimated CKD prevalence (by serum creatinine-based estimated glomerular filtration rate (eGFR) and dipstick urine albumin); and estimated prevalence of CKD risk factors (diabetes, hypertension and obesity). Logistic regression was used to determine independent predictors of CKD. One thousand nine hundred seventy eight persons, from Nevis (n = 950) and St. Kitts (n = 1028) were screened by the Caribbean Health and Education Foundation. Participants' mean age was 49 ± 15 years, 65% were female, and 99% were black. Fully, 21.5% had diabetes and 53.1% had hypertension; and 40.3% were obese. Mean estimated eGFR was 98 ml/min/1.73 m(2) (standard deviation = 30) and 4.7% had an eGFR Nevis (n = 929), 13.5% had urine albumin ≥30 mg/dL, and diabetes was an independent predictor of this finding (OR = 2.43, 95% CI 1.53-3.87). CKD and its risk factors were prevalent among adults in St. Kitts and Nevis. Public policy strategies for prevention and treatment of these conditions may be needed to reduce their associated morbidity, mortality and costs.
Antigua und Barbados. - Belize. - Saint Christopher (Kitts) und Nevis. - Saint Vincent und die Grenadinen. - Von Großbritannien abhängige Territorien / Rainer- Olaf Schultze ; Cornelia Will. - In: Politisches Lexikon Lateinamerika / hrsg. von Peter Waldmann ... - 3., neubearb. Aufl. - München : Beck, 1992. - S. 14-16, 43-47, 276-279, 283-286, 338-352. - (Beck´sche Reihe ; 845 : Aktuelle Länderkunden)
Gugnani, Harish Chander; Sharma, Soni; Gupta, Brijinder; Gaddam, Srinivas
Information on the prevalence of keratinophilic fungi in West Indies is scanty. Occurrence of keratinophilic fungi in soils of St. Kitts and Nevis has not been investigated previously. The prevalence of keratinophilic fungi was investigated in 108 samples of soils of varying habitats from St. Kitts and 55 such samples from Nevis by hair-baiting technique. Fungal growths appearing on the hair baits after four to eight weeks of incubation at room temperature were microscopically examined and cultured on mycological media. Cultures were identified on the basis of colonial and microscopic features. Forty-nine (45%) of the samples from St. Kitts and 38 (69%) from Nevis were positive for keratinophilic fungi. Microsporum gypseum complex, a well-known geophilic dermatophyte, was the most frequently recovered species being present in 15.7% of soils of St. Kitts and 40% of soils of Nevis. The next commonest species recovered was Chrysosporium indicum, represented by 15 (13.9%) isolates from St. Kitts and seven (12.7%) isolates from Nevis. Other infrequently isolated keratinophilic species included Chrysosporium tropicum, Chrysosporium keratinophilum, and unidentified Chrysosporium species. This study is the first of its kind in the islands of St. Kitts and Nevis. A high incidence of M. gypseum complex in the soil of these islands is a noteworthy finding of public health significance.
The project has the following specific objectives in Peru and St. Kitts and Nevis: - To measure alcohol consumption patterns; -To document policy-relevant behaviours, including place and time of purchase, prices paid, and exposure and salience of marketing; and, -To analyze the potential effects of pricing policies, ...
Gillian A. Lowe
Full Text Available There has been limited research on depressive symptoms among high school students in St. Kitts and Nevis. This project examines levels of depressive symptoms among fourth form (grade 10 students attending all high schools in St. Kitts and Nevis. Students enrolled in the fourth form during the 2006/2007 academic year in all high schools were administered the Beck Depression Inventory II (BDI-II. A near census of the students was conducted (n = 744 students; 50.4% females, 47.6% males, and 2% no gender reported; age 13–19 years, mean = 15.5 ± 0.8 years. Six in every ten students (62.1% reported some symptoms of depression, with 14.8% reporting moderate to severe and 9.7% reporting severe symptoms of depression. Females reported significantly higher BDI-II scores (t(727 = 7.11, p < 0.01 with 70% of females reporting some level of depressive symptoms compared with 52% of their male counterparts (X2(1 = 24.6, p < 0.05. Additionally, 34% of females were in the moderate to severe or severe range of depressive symptoms, while 15% of males were in the same range. Students who were older than expected for their grade (i.e., 17 years or older reported significantly higher BDI-II scores (F(2,740 = 2.88, p < 0.05 than students who were younger or at the expected age (i.e., 14–16 years. Students whose mothers had a high school or postsecondary education reported significantly lower levels of depressive symptoms than students whose mothers had less than a high school education (F(3, 637, = 4.23, p < 0.05. Symptoms of depression among fourth form students in St. Kitts and Nevis are a prevalent problem that is influenced by students’ age, gender, and social class as indicated by maternal education.
Gussler, J D; Mock, N
Infant feeding issues and research commonly portray infant feeding practices as a dichotomous variable; i.e., breastfeeding vs. bottlefeeding. This research establishes the complexity and variability in infant feeding patterns in 3 sites in the developing world. Comparative data are presented on the modes and products used to feed infants in Kinshasa, Zaire; St. Kitts-Nevis, West indies; and Cebu City, Philippines. They demonstrate that in these areas most infants receive some breastmilk. Bottlefeeding is also common but is rarely the exclusive mode of feeding. And the prevalence, manner of use, and role of the bottle varies among the 3 sites. Early supplementation of breastmilk by a variety of liquids, semisolids, and solids is typical of all 3 areas. These findings have important implications for educators and policymakers, as well as for research efforts relating infant feeding practices to infant health outcomes.
Nigeria, Papua New Guinea, Rwanda, Saint Kitts & Nevis , Saint Lucia, Saint Vincent & the Grenadines, Senegal, Sierra Leone, Solomon Islands, South...St Kitts and Nevis , St Lucia, St Vincent and the Grenadines, Senegal, Sierra Leone, Solomon Islands, South Africa, Suriname, Swaziland, Tanzania...Grenada, Guyana, Jamaica, St Kitts and Nevis , St Lucia, St Vincent and the Grenadines, Trinidad and Tobago, Suriname
... the Federation of Saint Kitts and Nevis has become a ``high-income'' country. I am terminating the... designation of the Federation of Saint Kitts and Nevis as a beneficiary developing country for purposes of the..., general note 4(a) to the HTS is modified by deleting ``St. Kitts and Nevis'' from the list of independent...
The AEP focuses on availability, taxation, and influences on alcohol prices, drinking and driving, and marketing and promotion. They will also conduct a longitudinal survey of individuals at the community level. This lAC survey comprises several outcome measures, such as alcohol consumption and the volume of alcohol ...
... Romania, Russian Federation, Rwanda, Saint Bartelemey, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Self-Pay, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (Dutch part), Slovakia (Slovak Republic), Slovenia ...
Land cover and forest formation distributions for St. Kitts, Nevis, St. Eustatius, Grenada and Barbados from decision tree classification of cloud-cleared satellite imagery. Caribbean Journal of Science. 44(2):175-198.
E.H. Helmer; T.A. Kennaway; D.H. Pedreros; M.L. Clark; H. Marcano-Vega; L.L. Tieszen; S.R. Schill; C.M.S. Carrington
Satellite image-based mapping of tropical forests is vital to conservation planning. Standard methods for automated image classification, however, limit classification detail in complex tropical landscapes. In this study, we test an approach to Landsat image interpretation on four islands of the Lesser Antilles, including Grenada and St. Kitts, Nevis and St. Eustatius...
..., Saint Lucia, and Trinidad and Tobago. Antigua and Barbuda, Aruba, The Bahamas, British Virgin Islands, Dominica, Grenada, Montserrat, Saint Kitts and Nevis, Saint Vincent and the Grenadines currently receive...
Helmer, E.H.; Kennaway, T.A.; Pedreros, D.H.; Clark, M.L.; Marcano-Vega, H.; Tieszen, L.L.; Ruzycki, T.R.; Schill, S.R.; Carrington, C.M.S.
Satellite image-based mapping of tropical forests is vital to conservation planning. Standard methods for automated image classification, however, limit classification detail in complex tropical landscapes. In this study, we test an approach to Landsat image interpretation on four islands of the Lesser Antilles, including Grenada and St. Kitts, Nevis and St. Eustatius, testing a more detailed classification than earlier work in the latter three islands. Secondly, we estimate the extents of land cover and protected forest by formation for five islands and ask how land cover has changed over the second half of the 20th century. The image interpretation approach combines image mosaics and ancillary geographic data, classifying the resulting set of raster data with decision tree software. Cloud-free image mosaics for one or two seasons were created by applying regression tree normalization to scene dates that could fill cloudy areas in a base scene. Such mosaics are also known as cloud-filled, cloud-minimized or cloud-cleared imagery, mosaics, or composites. The approach accurately distinguished several classes that more standard methods would confuse; the seamless mosaics aided reference data collection; and the multiseason imagery allowed us to separate drought deciduous forests and woodlands from semi-deciduous ones. Cultivated land areas declined 60 to 100 percent from about 1945 to 2000 on several islands. Meanwhile, forest cover has increased 50 to 950%. This trend will likely continue where sugar cane cultivation has dominated. Like the island of Puerto Rico, most higher-elevation forest formations are protected in formal or informal reserves. Also similarly, lowland forests, which are drier forest types on these islands, are not well represented in reserves. Former cultivated lands in lowland areas could provide lands for new reserves of drier forest types. The land-use history of these islands may provide insight for planners in countries currently considering
Full Text Available Describes the history of the recurring impulse for independence from the St. Kitts-Nevis state on the part of Nevis. Author examines the modern political history of the St. Kitts-Nevis state, in order to discern the motivations of the Nevisian people and politicians for their wish of secession. First, he sketches how Nevis and St. Kitts were historically linked since the 17th c., but that socioeconomic differences developed; as after the decline of sugar and plantation agriculture on both islands, St Kitts developed a largely proletarian rural population, whereas Nevis' population came to consist more of smallholders, resulting in the labour movement having more influence in St Kitts than in Nevis, which also had political repercussions. Nevisian parties favoured secession. Author reconstructs elections, partisan and general political developments in the St. Kitts-Nevis union since the 1950s, describing the long dominance of the St. Kitts-dominated Labour Party, and responses in Nevis. For Nevisian secession there seemed to be popular support. In 1998, however, the required majority on Nevis for secession was not obtained. Author concludes that the Nevisian wish for secession did not stem from any strong nationalistic zeal, or a particularly strong sense of separate identity or ethnicity, but mainly from economic and political reasons.
Goldstein, Alisa M; Tucker, Margaret A.
Dysplastic nevi (DN) are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these two entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to define them, and their biological importance. Their role as precursor lesions for melanoma is ...
Goldstein, Alisa M.; Tucker, Margaret A.
Dysplastic nevi (DN) are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these two entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to define them, and their biological importance. Their role as precursor lesions for melanoma is not their primary role in their relationship to melanoma because of the rarity of transformation of any individual nevus to a melanoma. Although there is still no single universally agreed upon histologic or clinical definition or even name for these nevi, dysplastic nevi should be considered important because of their association with an increased risk for melanoma. PMID:23549396
Goldstein, Alisa M; Tucker, Margaret A
Dysplastic nevi are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these 2 entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to define them, and their biologic importance. Their role as precursor lesions for melanoma is not their primary role in their relationship to melanoma because of the rarity of transformation of any individual nevus to a melanoma. Although there is still no single, universally agreed upon histologic or clinical definition or even name for these nevi, dysplastic nevi should be considered important because of their association with an increased risk for melanoma.
May 21, 1997 ... Eritrea, Fiji, Guinea, Lebanon, Mauritania, Myanmar, Niger, Nigeria, Palau, Saint Kitts &Nevis, Saint Lucia,. Saint Vincent and the Grenadines, Senegal, Solomon Islands, Sri Lanka, Swaziland, Tajikistan, The former. Yugoslav Republic of Macedonia, Turkmenistan, Uganda, Zaire, Zimbabwe. 27 WOUTERS ...
Ko, Christine J; McNiff, Jennifer M; Glusac, Earl J
Nevi with cytologic characteristics of Spitz nevus and architectural features of Clark's/dysplastic nevus are not well recognized in the literature. Twenty-seven nevi with characteristics of Spitz nevus and Clark's/dysplastic nevus are reviewed. The patients' mean age was 33 years, and 17/27(63%) patients were female. Lesions were most frequent on the trunk and lower extremities. Histopathologically, these nevi were composed of large, monomorphous spindled and/or epithelioid melanocytes. Spindle cells were often oriented parallel to the epidermis, with fused rete and lamellar fibroplasias. Lateral extension of the junctional component was a feature of compound lesions. An average of 10 years of clinical follow up in 12 patients revealed no recurrence or metastasis. Recognition of this type of nevus is important to avoid confusion with malignant melanoma. 2009 John Wiley & Sons A/S.
Paraguay 2005 Temporarily present in Paraguay Qatar 1992 Text classified Saint Kitts and Nevis 1987 Present in connection with their official duties... Saint Lucia 2000 Present in St. Lucia in connection with military exercises and training, counter-drug related activities, U.S. security assistance
Full Text Available Leptospirosis is a global zoonosis caused by pathogenic spirochetes classified within the genus Leptospira. Leptospires live in the proximal renal tubules of reservoir or chronic carrier animals, and are shed in the urine. Naïve animals acquire infection either when they come in direct contact with a reservoir or infected animals or by exposure to environmental surface water or soil that is contaminated with their urine. In this study, urine samples from a herd of donkeys on the Caribbean island of St. Kitts were screened using a TaqMan-based real-time quantitative polymerase chain reaction (qPCR targeting a pathogen-specific leptospiral gene, lipl32. Out of 124 clinically normal donkeys, 22 (18% tested positive for leptospiral DNA in their urine. Water samples from two water troughs used by the donkeys were also tested, but were found to be free from leptospiral contamination. Detection of leptospiral DNA in the urine of clinically healthy donkeys may point to a role that these animals play in the maintenance of the bacteria on St. Kitts.
Integration Association n.e.s. Martinique Montserrat Netherland Antiles Nicaragua Panama Paraguay Peru Rest of South America n.e.s. Saint Kitts and... Nevis Saint Vincent and the Grenadines Suriname Trinidad and Tobago Turks and Caicos Islands Uruguay Venezuela Virgin Islands (British...Africa n.e.s. Oman Other Africa n.e.s. Qatar Reunion Rwanda Saint Helena Sao Tome and Principe Saudi Arabia Senegal Seychelles Sierra Lione
..., Marie-Galante, Martinique, Miquelon, Montserrat, Saba, Saint Barthélemy, Saint Christopher, Saint Eustatius, Saint Kitts-Nevis, Saint Lucia, Saint Maarten, Saint Martin, Saint Pierre, Saint Vincent and...
Saints are central for personal devotion, as intercessors and mediators between humanity and God, and as models for emulation. Relationships with and images of saints and holy figures are by no means fixed, but have developed, mirrored and challenged different times and cultures. Sainthood is a p...
In contrast to what has so far generally been believed, dysplastic nevi do not appear to be mendelizing, but rather due to polygenic inheritance. In order to explain this contrasting idea, the following six theses are presented: (1) All dysplastic nevi are inherited in the same manner. (2) Dysplastic nevi constitute a continuous trait. (3) A "dysplastic nevus syndrome" in the form of a monogenic autosomal dominant trait probably does not exist. (4) A nonhereditary dysplastic nevus syndrome does not exist. (5) The number of the underlying genes that, considered separately, do of course follow the rules of mendelian inheritance is so far unknown. (6) A search for a single underlying gene defect is probably hopeless.
Boyd, Alan S; Shakhtour, Bashar; Shyr, Yu
Minichromosome maintenance (MCM) proteins are a recently elucidated group of polypeptides intimately involved in DNA replication and appreciable only in cycling cells. In other organ systems their expression has proven more prognostically useful than cell proliferation markers such as Ki-67 and proliferating cell nuclear antigen. To date, the evaluation of MCM proteins in melanocytic neoplasms has not been undertaken. We sought to determine whether MCM protein 2 (the most extensively evaluated of the MCM protein family) is present in melanocytes from benign nevi, dysplastic nevi, primary cutaneous melanomas, and cutaneous melanoma metastases and, if so, whether there exists a significant difference in expression among the 3 groups. Immunohistochemical staining for MCM 2 was performed on tissue sections from 10 benign nevi, dysplastic nevi, and primary cutaneous melanomas and from 5 cutaneous melanoma metastases. Approximately 200 cells were evaluated microscopically in 5 separate fields for each specimen and the number of positively staining nuclei was counted. After a percentage was calculated for each lesion, the data were pooled and statistically analyzed. Melanocyte nuclear staining was readily visible microscopically. The percentage of positively staining nuclei in benign nevi (1.2%), dysplastic nevi (6.1%), primary cutaneous melanomas (49.1%), and cutaneous melanoma metastases (40.9%) was significantly different (P benign nevi and melanoma, dysplastic nevi and melanoma, benign nevi and cutaneous melanoma metastases, and dysplastic nevi and cutaneous melanoma metastases. There was no statistically significant difference between cutaneous melanoma metastases and primary cutaneous melanoma. This is a small pilot study without blinded evaluation of the tissue sections and lacking correlation with patient clinical outcome or accepted histologic prognostic factors. MCM protein expression appears to differ significantly in melanocytic neoplasms and potentially
Elder, David E
Melanocytic nevi, which are benign tumors of melanocytes, may have occasional cosmetic significance but, for the most part, they are important only in relation to melanoma. Nevi are the most important simulants of melanoma, both clinically and histologically, and can usually be reliably distinguished from melanomas using published criteria. Some lesions are characterized by greater degrees of atypia and may be more difficult to diagnose. Dysplastic nevi are among the most important simulants of melanoma. Nevi may also be important as potential precursors of melanoma; however, most nevi are stable and will not progress to malignancy. Nevi are vastly more common than melanomas and the rate of progression of individual lesions is very low. Therefore, nevi are not as a rule managed by wholesale excision to prevent melanoma. Nevi are also important as risk markers, identifying individuals at greater risk of developing melanoma in the future. Dysplastic nevi and, to a lesser extent, common acquired and congenital nevi are among the most important melanoma risk markers. Nevi of special sites have been identified as nevi that may show atypical features suggestive of a dysplastic nevus or of a melanoma. However, they are not risk markers and they are not malignancies. Nevi of genital skin, acral skin, and flexural skin are among the most important 'nevi of special sites'. It is important, in considering the differential diagnosis of a lesion in a special site, to avoid overcalling such a lesion as a melanoma or a dysplastic nevus because this could lead to excessive treatment. Conversely, it is important to avoid undercalling a lesion that is a dysplastic nevus or a melanoma as a nevus of special sites, because in this circumstance a patient could lose the opportunity either for surveillance to recognize a developing melanoma at an early, curable stage, or for definitive treatment of an established malignancy. In this monograph, dysplastic nevi and nevi of special sites are
Clarke, Loren E
Patients with multiple dysplastic nevi have an increased risk for malignant melanoma, and dysplastic nevi themselves have at least some potential for malignant transformation. Development of malignant melanoma is uncommon within dysplastic nevi, however. Since this transformation occurs in other types of nevi, their role as a marker of increased risk for melanoma in the patients who bear them seems to be of greater significance. This article discusses the gross, clinical and microscopic features; diagnosis; and prognosis of dysplastic nevi. The key features and pitfalls of diagnosing malignant melanoma, congenital nevus, and recurrent nevus are given. Copyright © 2011 Elsevier Inc. All rights reserved.
Baran, Johanna L; Duncan, Lyn M
Combined melanocytic nevi are composed of 2 or more distinct populations of nevomelanocytes. Most commonly used to describe the combination of blue nevi with common nevi, it may also be applied to other combinations of benign melanocytic proliferations, including Spitz nevi and nevi with deep dermal pigmented nevomelanocytes. We report the incidence and distribution of these tumors at the Massachusetts General Hospital over the past decade and review guidelines for diagnostic criteria and nomenclature. Between 2000 and 2010 we identified 511 cases of combined nevi, represented by 4 histologically distinct diagnostic categories: (1) blue nevus, (2) nevi with deep dermal pigmented nevomelanocytes (plexiform/deep penetrating, inverted type A/clonal), (3) Spitz or pigmented spindled cell nevus, combined with another type of nevus (usually common or dysplastic), and (4) other combinations including 2 or more nevus types. Nearly one fifth of these tumors displayed atypical features; atypia was observed more often in combined nevi with Spitz or deep pigmented elements (26 of 55, 47%, and 25 of 98, 26%, respectively) than in combined common and blue nevi (37 of 336, 11%). Clinical follow-up data were available for 83% of the patients with atypical combined nevi; none developed recurrence or metastasis with a mean follow-up of over 4 years.
Guttman-Yassky, Emma; Bergman, Reuven; Manov, Lena; Sprecher, Eli; Shaefer, Yan; Kerner, Hedviga
Telomerase is a ribonucleoprotein DNA polymerase that is capable of synthesizing telomeres onto the ends of chromosomes. The cumulative loss of telomerase activity is believed to be associated with cell senescence. Telomerase activity has been shown to be higher in malignant melanomas than in common melanocytic nevi. The aim of the present study was to elucidate the pattern of expression of the human telomerase RNA (hTER) component in routinely processed specimens of Spitz nevi, malignant melanomas, and ordinary melanocytic nevi. Ten specimens of each type of tumor were studied, using an in situ hybridization technique. All three types of tumors demonstrated moderate to high intensities of hTER expression, usually in more than half of the tumor cells, and the majority of the studied lesions in each group did not show stratification of staining. The hTER component was also detected in the epidermis, sweat glands, and pilosebaceous units. hTER levels do not necessarily correlate with the level of telomerase activity, and the level and pattern of hTER expression are not useful as an adjunct to the histologic differential diagnosis of Spitz nevi from melanocytic nevi and malignant melanomas.
In March 1958 Dr. J. H. WESTERMANN and Mr. H. KIEL collected some fossil Echinids on the islands of St. Kitts and St. Eustatius. The fossils of St. Kitts were found in a yellow limestone (sample nr. 42), situated on the west flank of Brimstone Hill, belonging to a series of peculiar-looking upturned
Bergman, R; Kerner, H; Manov, L; Friedman-Birnbaum, R
The expression of c-fos protein was studied in formalin-fixed, paraffin-embedded sections of 11 compound Spitz nevi (SNs), 16 ordinary compound melanocytic nevi (MNs), and 17 malignant melanomas (MMs) using monoclonal antibody MAB1283 and an immunoperoxidase technique. Eleven (100%) SNs, 15 (94%) MNs, and 16 (94%) MMs showed positive reactions in some of the tumor cells (p = nonsignificant). In the majority of the tumors the staining was located in nuclei and graded as moderate to strong in intensity. The percentages of positively stained cells did not differentiate the three types of tumor, although they were higher in the melanocytic nevi. Most of the lesions with a significant dermal component did not show stratification of staining with progressive descent into the dermis. Positive staining for c-fos was also frequently found in the normal skin constituents within and adjacent to the melanocytic tumors. In conclusion, the pattern of expression of c-fos in routinely processed specimens does not differentiate between SNs, MNs, and MMs.
Simhaee, Daniel; Dolz-Marco, Rosa; Freund, K Bailey
To report two cases of choroidal nevi associated with focal choroidal excavation (FCE) and polypoidal choroidal neovascularization (PCN). Report of two patients with choroidal nevi showing FCE and PCN who underwent multimodal imaging including color fundus photography, fluorescein angiography, indocyanine green angiography, fundus autofluorescence, spectral domain optical coherence tomography, swept-source optical coherence tomography, and optical coherence tomography angiography. Two patients presented with choroidal nevi associated with FCE and PCN. In the first case, a 74-year-old woman, the nevus had sharp margins, a deep FCE, surrounding drusen, and subretinal exudation at its inferior edge due to PCN that responded well to intravitreal anti-vascular endothelial growth factor therapy. In the second case, a 64-year-old woman, the nevus had ill-defined margins, a shallow FCE, and angiographic evidence of PCN without associated exudation. There have been several reports showing an association of either choroidal nevi or FCE with PCN. To our knowledge, there have been no previous reports of FCE identified within choroidal nevi, with or without associated PCN. Since, in one of our cases, the FCE was not apparent on clinical examination, the prevalence of FCE within nevi may be underdiagnosed.
Chokoeva, A A; Ananiev, J; Wollina, U; Tana, C; Lotti, T; Cardoso, J C; Tchernev, G
IMP-3 is generally considered as an oncofetal protein, which plays a critical role in regulation of cell proliferation via an IGF-II-dependent pathway in K562 leukemia cells. IMP-3 expression has been detected in malignancies with various origins, while its appearance in adult tissue is generally considered abnormal, with some exceptions. IMP3 is also considered a prognostic biomarker in patients with renal cell carcinoma and clear-cell type ovarian carcinoma, hepatocellular carcinoma, pancreatic ductal adenocarcinoma and in patients with poorly differentiated thyroid carcinoma and uterine cervical carcinomas, testicular cancer and malignant melanoma. To our knowledge, no more than 4 PubMed-indexed studies have investigated the expression of IMP-3 in melanocytic lesions, namely its role in the differentiation between benign and malignant neoplasms. We investigated the expression of IMP-3 in a small series of benign melanocytic lesions, dysplastic nevi and melanomas, aiming to establish its significance as a marker for their distinction, comparing the results with those from the literature. IMP- 3 immunostaining was performed in 30 melanocytic lesions: 10 malignant melanomas, 10 dysplastic nevi and 10 benign melanocytic nevi. Our results revealed expression in 20% of dysplastic lesions and 40% of melanoma cases, while none of the benign nevi showed positive expression. These data contradict some of the results from other studies and raise some questions regarding the correlation between IMP- 3 and the degree of dysplasia of melanocytic nevi, as well as its potential relationship with prognostic parameters in melanoma, including tumor thickness and mitotic rate. Our results suggest that IMP-3 expression could be only an auxiliary marker for differentiation between dysplastic nevi and benign nevi, since although it is not expressed in all dysplastic lesions, staining correlates with the degree of dysplasia/atypia. It seems that IMP-3 expression is not a useful
Murat Orhan Oztas
Conclusions: Our study describes the normal clinical and dermoscopic features of CMN. It should be kept in mind that, CMNs are quite common lesions, and melanomas can arise from them. Knowing and being familiar with the normal properties of these common nevi will help us determine whether a nevus is suspicious or not.
Fischer, Marc; Staples, J Erin
In December 2013, the World Health Organization reported the first local transmission of chikungunya virus in the Western Hemisphere, with autochthonous cases identified in Saint Martin. Since then, local transmission has been identified in 17 countries or territories in the Caribbean or South America (Anguilla, Antigua and Barbuda, British Virgin Islands, Dominica, Dominican Republic, French Guiana, Guadeloupe, Guyana, Haiti, Martinique, Puerto Rico, Saint Barthelemy, Saint Kitts and Nevis, Saint Lucia, Saint Martin, Saint Vincent and the Grenadines, and Sint Maarten). As of May 30, 2014, a total of 103,018 suspected and 4,406 laboratory-confirmed chikungunya cases had been reported from these areas. The number of reported cases nearly doubled during the previous 2 weeks. More than 95% of the cases have been reported from five jurisdictions: Dominican Republic (38,656 cases), Martinique (30,715), Guadeloupe (24,428), Haiti (6,318), and Saint Martin (4,113). The highest incidences have been reported from Saint Martin (115 cases per 1,000 population), Martinique (76 per 1,000), Saint Barthelemy (74 per 1,000), and Guadeloupe (52 per 1,000). Further expansion of these outbreaks and spread to other countries in the region is likely.
Almost all fair-skinned children demonstrate one or more pigment nevi at the integument. These usually develop in the first two decades of life as a result of an endogenous disposition and exogenous stimulants. While most pigmented nevi are per se harmless, congenital and atypical (dysplastic) nevi are considered as precursors of melanoma and risk indicators. Although one normal nevus in isolation generally presents no risk, children and adults with multiple pigment nevi are at increased risk of developing a melanoma in the course of their life. Since the onset of pigment nevi is undisputedly triggered by ultraviolet light, appropriate prevention and protection is crucial. The differential diagnosis between nevus cell nevi and melanoma is particularly challenging, especially in the case of atypical nevi.
National Oceanic and Atmospheric Administration, Department of Commerce — Binary point-cloud data for part of the submerged environs of Saint Croix and Saint Thomas, U.S. Virgin Islands, were produced from remotely sensed, geographically...
Melekhova, Elena; Blundy, Jon; Martin, Rita; Arculus, Richard; Pichavant, Michel
St. Kitts lies in the northern Lesser Antilles, a subduction-related intraoceanic volcanic arc known for its magmatic diversity and unusually abundant cognate xenoliths. We combine the geochemistry of xenoliths, melt inclusions and lavas with high pressure-temperature experiments to explore magma differentiation processes beneath St. Kitts. Lavas range from basalt to rhyolite, with predominant andesites and basaltic andesites. Xenoliths, dominated by calcic plagioclase and amphibole, typically in reaction relationship with pyroxenes and olivine, can be divided into plutonic and cumulate varieties based on mineral textures and compositions. Cumulate varieties, formed primarily by the accumulation of liquidus phases, comprise ensembles that represent instantaneous solid compositions from one or more magma batches; plutonic varieties have mineralogy and textures consistent with protracted solidification of magmatic mush. Mineral chemistry in lavas and xenoliths is subtly different. For example, plagioclase with unusually high anorthite content (An≤100) occurs in some plutonic xenoliths, whereas the most calcic plagioclase in cumulate xenoliths and lavas are An97 and An95, respectively. Fluid-saturated, equilibrium crystallisation experiments were performed on a St. Kitts basaltic andesite, with three different fluid compositions ( XH2O = 1.0, 0.66 and 0.33) at 2.4 kbar, 950-1025 °C, and fO2 = NNO - 0.6 to NNO + 1.2 log units. Experiments reproduce lava liquid lines of descent and many xenolith assemblages, but fail to match xenolith and lava phenocryst mineral compositions, notably the very An-rich plagioclase. The strong positive correlation between experimentally determined plagioclase-melt KdCa-Na and dissolved H2O in the melt, together with the occurrence of Al-rich mafic lavas, suggests that parental magmas were water-rich (> 9 wt% H2O) basaltic andesites that crystallised over a wide pressure range (1.5-6 kbar). Comparison of experimental and natural (lava
... Guinea Guinea-Bissau Guyana Haiti Heard Is and McDonald Is Holy See (Vatican City) Honduras Hungary Iceland ... Pitcairn Poland Portugal Puerto Rico Qatar Reunion Romania Russia Rwanda Saint Helena Saint Kitts and Nevis Saint ...
Angoori Gnaneshwar Rao
Full Text Available Amelanotic melanoma (AMM presenting as pyogenic granuloma and occurring in the vicinity of acquired melanocytic nevi is rare. Herein, we report such a manifestation in a 68-year-old male who presented with the painful red nodule and multiple pigmented patches involving the left great toe. Histopathological examination of skin biopsy taken from the nodule with an immunohistochemical study using HMB45 and S-100 confirmed the diagnosis of AMM. Biopsy from the pigmented patch near the nodule showed features of melanocytic nevus. Investigative work up revealed metastatic deposits in the left inguinal lymph node with no evidence of systemic involvement, placing him in malignant melanoma Stage IIIC of American Joint Committee on Cancer (AJCC tumor node metastasis system. The development of AMM in the vicinity of acquired melanocytic nevi and manifesting as granuloma pyogenicum is unique in this case.
Noz, K.C.; Bergman, W.; Schothorst, A.A. (Univ. Hospital Leiden (Netherlands). Dept. of Dermatology); Roza, L. (TNO Medical Biological Lab., Rijswijk (Netherlands)); Darroudi, F. (Rijksuniversiteit Leiden (Netherlands). Lab. voor Stralengenetica en Chemische Mutagenese)
We compared the induction of cyclobutane thymine dimers after exposure to 302 nm UV in foreskin-derived melanocytes and melanocytes from nevocellular nevi, as well as in melanocytes cultured from dysplastic nevi, precursor lesions of melanoma, derived from four, three and four individuals, respectively. Cyclobutane thymine dimers were quantified in situ by means of an immunofluorescence assay with a specific monoclonal antibody. A method was developed to compare separately performed experiments in a standardized manner. For melanocytes from each source, we demonstrated a linear relationship between UV dose and immunofluorescence. In nevocellular and dysplastic nevi, two subpopulations could be detected, distinguished by their nuclear size. Large nucleated nevocellular nevus cells were most susceptible to the induction of thymine dimers (49% higher induction compared to induction in foreskin melanocytes), while in normal-sized nuclei of these nevus cells the same induction of thymine dimers was found as in nuclei from foreskin melanocytes. In contrast, large nucleated dysplastic nevus melanocytes did not differ from the foreskin melanocytes, while normal-sized nuclei of dysplastic nevus cells showed a lower induction (32% lower induction than in foreskin melanocytes). (Author).
Hayes, C; Walker, K
Corinne Hayes and Karen Walker won 1000 pounds in last year's Student Elective Award competition for the protocol of their project. Here, they give an account of their work, the aims of which were to compare the incidence of low birthweight (less than 2.5 kg) and very low birthweight (less than 1.5 kg) babies in the UK and the Caribbean, to assess the outcome of these babies and to compare obstetric practice and the incidence of risk factors for low birthweight in the two populations.
Full Text Available Nevi are common skin tumors caused by abnormal overgrowth of cells from the epidermal and dermal layers of the skin. Most nevi are benign, but some pre-cancerous nevi must be monitored or removed. The giant congenital nevus is greater than 10 cm in size, pigmented and often hairy. Between 4% and 6% of these lesions will develop into a malignant melanoma. Since approximately 50% of the melanoma develop by the age of two, and 80% by the age of seven, early removal is recommended. The objective of this paper is to present a unique case of giant nevi and their surgical management.
Gelpi, A P
The martyrdom of Saint Sebastian is one of the most enduring themes in Western religious art. The execution scene so often portrayed - with the Saint transfixed with arrows - is based on the legend about his life and death during the reign of the Roman emperor, Diocletian. However, it is the symbolic association of arrows with the Black Death - during the Middle Ages and during the Renaissance - which identifies Sebastian as the patron saint of plague victims. After more than four centuries of recurrent epidemics, the plague died out in Europe; but the image of St. Sebastian continued to inspire artists until the end of the 19th century.
Zacek, Natalie A.
Full Text Available This article examines a variety of texts produced by the French and English colonists of the island of St Kitts in the seventeenth and eighteenth centuries. During this time, the island was jointly settled by these two groups, a situation which created considerable tension and frequent hostilities between them. By placing these texts in dialogue with one another, we gain a clearer and more nuanced understanding of the extent to which these competing imperial projects resembled and differed from one another, allowing us a new perspective on European settlement in the Caribbean in the era of slavery.Este artículo examina la variedad de textos producida por los colonos franceses e ingleses de la isla de St. Kitts (San Cristóbal en los siglos XVII y XVIII, momento en que ambas comunidades se hallaban asentadas en este mismo territorio lo que generó mucha tensión y enfrentamientos frecuentes. La puesta en diálogo de estos textos permite entender las similitudes y diferencias entre los dos proyectos imperiales y ofrece una nueva perspectiva del asentamiento europeo en el Caribe en la época de la esclavitud.
Chin, Szu-Ying; Wu, Pei-Ru; Shih, Yi-Hsien; Yeh, Chung-Min; Lee, Woan-Ruoh; Shen, Shing-Chuan; Yeh, Kun-Tu; Jiang, Ming-Chung; Tseng, Jonathan Te-Peng
Melanoma is difficult to treat when it has metastasized. Discrimination between melanoma and benign nevi in melanocytic lesions is crucial for identifying melanomas and consequently improving melanoma treatment and prognosis...
Sahely, H.; Nettles, S.; Burrowes, R.; Haas, G.
Water resources in small island developing states (SIDS), especially those in the Caribbean are among the most vulnerable systems to human activities and climate change. This vulnerability is exacerbated by a fragmented approach to water resources management. The unconfined coastal aquifer underlying the Basseterre Valley is a significant asset for the people of St. Kitts-Nevis. The potable water extracted from this aquifer represents over 40% of the total water supply for St. Kitts. The area is subject to urban encroachment, inappropriate land use and threats from pollution. A project was implemented using an integrated approach to help government and communities take practical actions to protect this vulnerable aquifer by demonstrating proper management on three fronts: mitigation of threats from contaminants, protection of the aquifer and improved water resources management. The project is funded by the Global Environment Facility (GEF) as part of the Integrating Watershed and Coastal Areas Management (IWCAM) project for Caribbean Small Island States. A comprehensive hydrogeologic evaluation of the aquifer was undertaken in order to aid in the development of a water resources management strategy for the Basseterre Valley Aquifer. Multi-electrode electrical resistivity (MER), a novel surface geophysical technique, was used to delineate the thickness and distribution of sediments throughout the aquifer, zones of increased porosity, zones of possible contamination and the fresh/salt water interface. Together with slowly declining static water levels and elevated dissolved solids levels, the early stages of salt water intrusion have been documented. Groundwater modelling suggests that adjusting the pumping regime, redeveloping some of the existing wells and relocating other wells is a viable option for increasing efficiency and preventing long term dewatering. Overall, the study has provided a wealth of new information about the aquifer for a reasonable cost. A
Scope, Alon; Marchetti, Michael A.; Marghoob, Ashfaq A.; Dusza, Stephen W.; Geller, Alan C.; Satagopan, Jaya M.; Weinstock, Martin A.; Berwick, Marianne; Halpern, Allan C.
Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of the morphologic characteristics of nevi in different anatomic locations, in association with the patient’s age and pigmentary phenotype may aid in the identification of melanomas. When monitoring melanocytic lesions over time, it is essential to differentiate normal from abnormal change. In this review, we summarize the rapidly expanding body of literature, particularly in the context of our experience with the Study of Nevi in Children (SONIC) Project. PMID:27320410
Husain, Ehab A; Mein, Charles; Pozo, Lucia; Blanes, Alfredo; Diaz-Cano, Salvador J
Atypical (dysplastic) melanocytic nevi are clinically heterogeneous malignant melanoma precursors, for which no topographic analysis of cell kinetic, cell cycle regulators and microsatellite profile is available. We selected low-grade atypical melanocytic nevi (92), high-grade atypical melanocytic nevi (41), melanocytic nevi (18 junctional, 25 compound) and malignant melanomas (16 radial growth phase and 27 vertical growth phase). TP53, CDKN2A, CDKN1A, and CDKN1B microsatellite patterns were topographically studied after microdissection; Ki-67, TP53, CDKN2A, CDKN1A, and CDKN1B expressions and DNA fragmentation by in situ end labeling for apoptosis were topographically scored. Results were statistically analyzed. A decreasing junctional-dermal marker expression gradient was observed, directly correlating with atypical melanocytic nevus grading. High-grade atypical melanocytic nevi revealed coexistent TP53-CDKN2A-CDKN1B microsatellite abnormalities, and significantly higher junctional Ki67-TP53 expression (inversely correlated with CDKN1A-CDKN1B expression and in situ end labeling). Malignant melanomas showed coexistent microsatellite abnormalities (CDKN2A-CDKN1B), no topographic gradient, and significantly decreased expression. Melanocytic nevi and low-grade atypical melanocytic nevi revealed sporadic junctional CDKN2A microsatellite abnormalities and no significant topographic kinetic differences. High-grade atypical melanocytic nevi accumulate junctional TP53-CDKN1A-CDKN1B microsatellite abnormalities, being progression TP53-independent and better assessed in the dermis. Melanocytic nevi and low-grade atypical melanocytic nevi show low incidence of microsatellite abnormalities, and kinetic features that make progression unlikely.
Loftis, Amanda D; Kelly, Patrick J; Freeman, Mark D; Fitzharris, Susan; Beeler-Marfisi, Janet; Wang, Chengming
Between 2009 and 2011, we conducted a case-control study of ticks and tick-associated pathogens affecting dogs on the island of St. Kitts, eastern Caribbean, including 55 cases of clinically suspected tick-borne disease (TBD) and 110 presumably healthy animals presented for elective surgeries. Rhipicephalus sanguineus caused year-round infestations of dogs, and 36% of the dogs in the study were infested at the time of examination. Overall, 62% of suspected TBD cases and 24% of presumably healthy dogs tested positive by PCR for infections with: Anaplasma platys (0% and 4%), Babesia canis vogeli (20% and 6%), Babesia gibsoni (18% and 5%), Ehrlichia canis (35% and 7%), and Hepatozoon canis (5% and 2%). Co-infections were documented in 15% of these PCR-positive dogs. Antibodies against A. platys or E. canis were noted in 36% of the dogs. Thrombocytopenia was the most common sign of infection, followed by anemia. This is the first detection of A. platys, B. canis vogeli, or H. canis on St. Kitts and the first detection of B. gibsoni in the Caribbean. We conclude that tick-borne pathogens of dogs are highly prevalent in this region and may present in dogs that appear healthy, in spite of hematologic abnormalities that may increase surgical risk. Copyright © 2013 Elsevier B.V. All rights reserved.
Breckinridge, J B; McAlister, H A; Robinson, W G
The speckle camera in regular use at Kitt Peak National Observatory since 1974 is described in detail. The design of the atmospheric dispersion compensation prisms, the use of film as a recording medium, the accuracy of double star measurements, and the next generation speckle camera are discussed. Photographs of double star speckle patterns with separations from 1.4 sec of arc to 4.7 sec of arc are shown to illustrate the quality of image formation with this camera, the effects of seeing on the patterns, and to illustrate the isoplanatic patch of the atmosphere.
SAINT KITTS AND NEVIS KN SAINT LUCIA LC SAINT MARTIN MF SAINT PIERRE-MIQUELON PM SAINT VINCENT-GRENADINES VC SAMOA WS...RÉUNION RE ROMANIA RO RUSSIAN FEDERATION RU RWANDA RW SAINT BARTHÉLEMY BL SAINT HELENA SH
Full Text Available Melanocytic nevi are uncommon lesions of the oral cavity. Most reports are of isolated cases or of a small series of cases. The purpose of this article is to report a case of oral melanocytic nevi and to review the literature. Review of literature revealed that about one third of patients with malignant melanoma had preexisting macular pigmentation present. Therefore, removal of all lesions suspected to be nevi is recommended. Oral lesions are uncommon and usually small that excision seems advisable.
Huang, Jennifer M; Chikeka, Ijeuru; Hornyak, Thomas J
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection. Published by Elsevier Inc.
León, Jorge E.; Carlos, Román; Delgado-Azañero, Wilson; Mosqueda-Taylor, Adalberto; Paes-de-Almeida, Oslei
Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions. Key words:Oral melanoma, oral nevi, Skp2, cell cycle, immunohistochemistry. PMID:23385514
King, Andy J; Gehl, Robert W; Grossman, Douglas; Jensen, Jakob D
Skin self-examination (SSE) is one method for identifying atypical nevi among members of the general public. Unfortunately, past research has shown that SSE has low sensitivity in detecting atypical nevi. The current study investigates whether crowdsourcing (collective effort) can improve SSE identification accuracy. Collective effort is potentially useful for improving people's visual identification of atypical nevi during SSE because, even when a single person has low reliability at a task, the pattern of the group can overcome the limitations of each individual. Adults (N=500) were recruited from a shopping mall in the Midwest. Participants viewed educational pamphlets about SSE and then completed a mole identification task. For the task, participants were asked to circle mole images that appeared atypical. Forty nevi images were provided; nine of the images were of nevi that were later diagnosed as melanoma. Consistent with past research, individual effort exhibited modest sensitivity (.58) for identifying atypical nevi in the mole identification task. As predicted, collective effort overcame the limitations of individual effort. Specifically, a 19% collective effort identification threshold exhibited superior sensitivity (.90). The results of the current study suggest that limitations of SSE can be countered by collective effort, a finding that supports the pursuit of interventions promoting early melanoma detection that contain crowdsourced visual identification components. Copyright © 2013 Elsevier Ltd. All rights reserved.
Balu, Mihaela; Kelly, Kristen M; Zachary, Christopher B; Harris, Ronald M; Krasieva, Tatiana B; König, Karsten; Durkin, Anthony J; Tromberg, Bruce J
Monitoring of atypical nevi is an important step in early detection of melanoma, a clinical imperative in preventing the disease progression. Current standard diagnosis is based on biopsy and histopathologic examination, a method that is invasive and highly dependent upon physician experience. In this work, we used a clinical multiphoton microscope to image in vivo and noninvasively melanocytic nevi at three different stages: common nevi without dysplastic changes, dysplastic nevi with structural and architectural atypia, and melanoma. We analyzed multiphoton microscopy (MPM) images corresponding to 15 lesions (five in each group) both qualitatively and quantitatively. For the qualitative analysis, we identified the morphologic features characteristic of each group. MPM images corresponding to dysplastic nevi and melanoma were compared with standard histopathology to determine correlations between tissue constituents and morphology and to evaluate whether standard histopathology criteria can be identified in the MPM images. Prominent qualitative correlations included the morphology of epidermal keratinocytes, the appearance of nests of nevus cells surrounded by collagen fibers, and the structure of the epidermal-dermal junction. For the quantitative analysis, we defined a numerical multiphoton melanoma index (MMI) based on three-dimensional in vivo image analysis that scores signals derived from two-photon excited fluorescence, second harmonic generation, and melanocyte morphology features on a continuous 9-point scale. Indices corresponding to common nevi (0-1), dysplastic nevi (1-4), and melanoma (5-8) were significantly different (P < 0.05), suggesting the potential of the method to distinguish between melanocytic nevi in vivo. ©2014 American Association for Cancer Research.
Zaytsev, Kirill I.; Chernomyrdin, Nikita V.; Kudrin, Konstantin G.; Gavdush, Arseniy A.; Nosov, Pavel A.; Yurchenko, Stanislav O.; Reshetov, Igor V.
The results of the in vivo terahertz (THz) pulsed spectroscopy (TPS) of pigmentary skin nevi are reported. Observed THz dielectric permittivity of healthy skin and dysplastic and non-dysplastic skin nevi exhibits significant contrast in THz frequency range. Dysplastic skin nevus is a precursor of melanoma, which is reportedly the most dangerous cancer of the skin. Therefore, the THz dielectric spectroscopy is potentially an effective tool for non-invasive early diagnosis of melanomas of the skin.
Nasti, Tahseen H.; Cochran, J. Barry; Tsuruta, Yuko; Yusuf, Nabiha; McKay, Kristopher M.; Athar, Mohammad; Timares, Laura; Elmets, Craig A.
Acquired melanocytic nevi are commonly found in sun exposed and unexposed human skin, but the potential for their transformation into invasive melanoma is not clear. Therefore, a mouse model of nevus initiation and progression was developed in C3H/HeN mice using a modified chemical carcinogenesis protocol. Nevi develop due to DNA damage initiated by dimethylbenz(a) anthracene (DMBA) followed by chronic promotion with 12?O?tetradecanoyl?phorbol?13?acetate (TPA). Dysplastic pigmented skin lesio...
Masaki, Taro; Wang, Yun; DiGiovanna, John J; Khan, Sikandar G; Raffeld, Mark; Beltaifa, Senda; Hornyak, Thomas J; Darling, Thomas N; Lee, Chyi-Chia R; Kraemer, Kenneth H
We examined nevi and melanomas in 10 xeroderma pigmentosum (XP) patients with defective DNA repair. The lesions had a lentiginous appearance with markedly increased numbers of melanocytes. Using laser capture microdissection, we performed DNA sequencing of 18 benign and atypical nevi and 75 melanomas (melanoma in situ and invasive melanomas). The nevi had a similar high frequency of PTEN mutations as melanomas [61% (11/18) versus 53% (39/73)]. Both had a very high proportion of UV-type mutations (occurring at adjacent pyrimidines) [91% (10/11) versus 92% (36/39)]. In contrast to melanomas in the general population, the frequency of BRAF mutations (11%, 7/61), NRAS mutations (21%, 13/62), and KIT mutations (21%, 6/28) in XP melanomas was lower than for PTEN. Phospho-S6 immunostaining indicated activation of the mTOR pathway in the atypical nevi and melanomas. Thus, the clinical and histological appearances and the molecular pathology of these UV-related XP nevi and melanomas were different from nevi and melanomas in the general population. © 2014 Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Laura Abdo Nalon de Queiroz Fuscaldi
Full Text Available A 10-year-old female patient, being treated for dystrophic bullous epidermolysis in a Pediatric Hospital, was referred to our Dermoscopy Ambulatory because of a newly observed mole in the submandibular area. Clinically, the lesion presented as an irregular double-colored macule of about 2 cm in diameter, with irregular borders, suspicious of malignancy. Dermoscopy showed a multicomponent pattern, with multiple colors, ill-defined network, black blotches, streaks, multiple dots, a blue-whitish veil and granularity at the periphery. Although it had a clinical appearance of malignancy, dermoscopy every semester was proposed due to the revision of a recently described entity, named bullous epidermolysis nevi, that we made in these children. The fragile skin of this particular patient was also taken into account, and overtreatment was avoided. Bullous epidermolysis nevi is the term given to large, asymmetrical and often irregularly pigmented melanocytic nevi that occur in former areas of blistering in patients with the dystrophic forms of the disease. Despite its atypical clinical appearance, and sometimes also atypical dermoscopy, malignant transformation has not been reported yet. Similarly to recurrent nevi, where melanocytes proliferate in a previous area of trauma, clinical aspect, dermoscopy, and histopathology may tempt clinicians to diagnose benign moles as melanoma. Here we report one case of this entity, scarcely reported on in literature, and review clinical and dermatoscopical features of epidermolysis bullosa nevi confronting it with recurrent nevi. The usefulness of dermoscopy as a treatment strategy is stressed.
Akhras, Victoria; Ramakrishnan, Rathi; Stanton, Anthony W B; Levick, John R; Cook, Martin G; Chong, Heung; Mortimer, Peter S
The density of functioning human lymphatics in vivo and of immunohistochemically defined lymphatics was quantified around melanomas, benign nevi, and matched normal skin, to assess the current lymphangiogenesis paradigm. We investigated whether histological and functioning density increased around melanomas compared with benign nevi or matched skin; whether functioning and histological density increased similarly; and whether larger increases occurred around metastatic melanomas. Functioning density was quantified in vivo as the total amount of human dermal microlymphatics taking up fluorescent marker injected at the lesion margin. After tissue excision, perilesion histological density was quantified using podoplanin marker D2-40. Histological density was raised similarly around metastasising and non-metastasising melanomas compared with normal skin (+71%, p benign nevi (+17%, p = 0.03, n = 20). In contrast, functioning lymphatic density was substantially reduced around the margins of melanomas (both metastasising and non-metastasising) compared with benign nevi (by 65%, p = 0.02) or normal skin (by 53%, p = 0.0014). Raised perilesion histological lymphatic density is not unique to melanoma but occurs also around benign nevi. The findings indicated that the number of functioning lateral lymphatics around human melanomas in vivo but not benign nevi is reduced, despite histologically increased numbers of lymphatics. © 2015 John Wiley & Sons Ltd.
Andersen, Astrid Oberborbeck
, at the same time as political elections and economic hardship. During one year of ethnographic fieldwork volcanoes, saints, trash and frogs were among the nonhuman entities referred to in conversations and engaged with when responding to the changes that trouble the world and everyday life of Arequipans...
Craig, Gregory W.; And Others
Surveys conducted in Minneapolis and Saint Paul, Minnesota, dealing with housing problems of urban Indians are reviewed in this report. Housing conditions, Indian attitudes toward urban housing and the community, family characteristics, and deficiencies in housing agencies are discussed. The surveys strongly indicate that Indians want better…
Mihail, A; Coman, G; Staniceanu, F; Coman, L; Zurac, S; Coman, O A
Reelin is an extracellular signaling protein synthesized by Cajal-Retius cells in utero and early after birth, its presence being signaled in adult life too. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons. We investigated the reelin presence and its receptors, VLDLR and ApoER2, in melanocytic nevi considering the neural crest origin of the nevus cells and their migration into skin during embrionary period. Melanocytic nevi present a strict cellular architecture and an increased malignant transforming capacity. We investigated reelin presence in 32 melanocytic nevi (5 junctional, 27 compound or 14 dysplastic nevi and 18 non dysplastic nevi). The assessment of reelin presence was performed by histological semiquantitative criteria. Results showed the presence of reelin in 29 cases (29/ 32). The presence of reelin was elevated in junctional areas as in dysplastic nevi. VLDLR presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases. Reelin or its receptors was peritumorally absent. Our study showed the presence of reelin in nevus cells from cutaneous melanocytic nevi and, in these cells, only the VLDLR receptor was present in half of the cases. The significance of the reelin presence in cutaneous nevus cells may be hypothetically considered correlated with the position maintenance of the nevus cells or migration of these cells in malignant transforming situation. Abbreviations: ApoER2 = apolipoprotein receptor 2, VLDLR = very low density lipoprotein receptor, DAB-1 = DIABLO protein, HMB45 = gene HMB45.
Rübben, Albert; Bogdan, Inja; Grussendorf-Conen, Elke-Ingrid; Burg, Günter; Böni, Roland
Acquired melanocytic nevi may show signs of histological dysplasia, and epidemiological studies have demonstrated that dysplastic melanocytic nevi (DMN) are associated with an elevated melanoma risk. Nevertheless, the concept of DMN as precursors of melanoma has remained a concept, in view of the difficulty of establishing unambiguous cytological and histological criteria for DMN. Recent molecular data suggest that genetic instability is more frequent in DMN than in benign acquired melanocytic nevi. We have analyzed 54 benign melanocytic nevi and 6 DMN for loss of heterozygosity (LOH) at microsatellite markers D9S171, IFNA, D9S270, D9S265. LOH at one or more loci was detected in 17 out of 54 benign nevi and in 4 out of 6 DMN. LOH was demonstrated at 26 out of 103 amplified and informative microsatellites in benign nevi and at 6 out of 11 microsatellites in DMN. In addition, 6 benign nevi and 6 DMN were microdissected in 4-15 regions per lesion and analyzed for LOH and microsatellite instability (MSI) at D9S162 and D14S53. Both LOH and MSI were detected more frequently in dysplastic nevi (LOH frequency 0.61 vs 0.18; MSI frequency 0.27 vs 0.05). These results confirm that genetic instability is more prevalent in DMN than in benign acquired melanocytic nevi. Therefore, DMN might be defined as a monoclonal and genetically unstable, but limited, melanocytic proliferation that distinguishes this entity from the benign nevus and from malignant melanoma.
Varga, Erika; Korom, Irma; Varga, János; Kohán, József; Kemény, Lajos; Oláh, Judit
In response to the demands of style and fashion, the number of decorative tattoos has been increasing worldwide. This has been paralleled by a rising incidence of melanocytic proliferations, including melanoma. The coincidence of various dermatological diseases and skin tumors with tattoos has been documented with some frequency, but reports of melanoma associated with tattoos are exceedingly rare. To date, only 13 cases have been documented in the English language literature. The possibility of an association between melanocytic proliferations and tattoos remains an area for further study. This report presents two cases of melanocytic nevi and one of melanoma occurring in association with a decorative tattoos. At present, the pathogenesis of melanoma developing in a tattoo is unknown. Mere coincidence cannot be ruled out. However, trauma, ultraviolet light exposure, a photoallergic effect, or an inflammatory reaction may promote malignant transformation. Clinicians and histopathologists should be aware of the clinical and pathological features if they are to make a correct diagnosis. Copyright © 2011 John Wiley & Sons A/S.
Full Text Available The relationship between telomeres, nevi and melanoma is complex. Shorter telomeres have been found to be associated with many cancers and with number of nevi, a known risk factor for melanoma. However, shorter telomeres have also been found to decrease melanoma risk. We performed a systematic analysis of telomere-related genes and tagSNPs within these genes, in relation to the risk of melanoma, dysplastic nevi, and nevus count combining data from four studies conducted in Italy. In addition, we examined whether telomere length measured in peripheral blood leukocytes is related to the risk of melanoma, dysplastic nevi, number of nevi, or telomere-related SNPs. A total of 796 cases and 770 controls were genotyped for 517 SNPs in 39 telomere-related genes genotyped with a custom-made array. Replication of the top SNPs was conducted in two American populations consisting of 488 subjects from 53 melanoma-prone families and 1,086 cases and 1,024 controls from a case-control study. We estimated odds ratios for associations with SNPs and combined SNP P-values to compute gene region-specific, functional group-specific, and overall P-value using an adaptive rank-truncated product algorithm. In the Mediterranean population, we found suggestive evidence that RECQL4, a gene involved in genome stability, RTEL1, a gene regulating telomere elongation, and TERF2, a gene implicated in the protection of telomeres, were associated with melanoma, the presence of dysplastic nevi and number of nevi, respectively. However, these associations were not found in the American samples, suggesting variable melanoma susceptibility for these genes across populations or chance findings in our discovery sample. Larger studies across different populations are necessary to clarify these associations.
Chin, Szu-Ying; Wu, Pei-Ru; Shih, Yi-Hsien; Yeh, Chung-Min; Lee, Woan-Ruoh; Shen, Shing-Chuan; Yeh, Kun-Tu; Jiang, Ming-Chung; Tseng, Jonathan Te-Peng
Melanoma is difficult to treat when it has metastasized. Discrimination between melanoma and benign nevi in melanocytic lesions is crucial for identifying melanomas and consequently improving melanoma treatment and prognosis. The chromosome segregation 1-like (CSE1L) protein has been implicated in cancer progression and is regulated by phosphorylation by extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, a critical pathway in melanoma progression. We studied phosphorylated CSE1L expression in human melanoma and benign nevi specimens. Immunohistochemistry with tissue microarray using antibody against phosphorylated CSE1L showed that melanomas exhibited considerable staining for phosphorylated CSE1L (100%, 34/34), whereas the benign nevi showed only faint staining (0%, 0/34). Melanomas mainly exhibited cytoplasmic phospho-CSE1L distribution, whereas the benign nevi mainly exhibited nuclear phospho-CSE1L distribution. Moreover, immunohistochemistry with anti-CSE1L antibody revealed that CSE1L mainly exhibited cytoplasmic/nuclear distribution and nuclear distribution was the dominant. Immunofluorescence with B16F10 melanoma cells showed cytoplasmic distribution of phospho-CSE1L and nuclear distribution of CSE1L. Our results indicated that nuclear CSE1L is mainly non-phosphorylated CSE1L and is involved in gene regulation and cytoplasmic CSE1L is mainly phosphorylated CSE1L and is involved in cytoplasmic signaling regulation in melanocytic tumorigenesis. Furthermore, immunohistochemical analysis of cytoplasmic phospho-CSE1L may aid in the diagnosis of melanoma.
.... Details of the cleaning tests are given, which show, amongst other things, that the drapery of Saint John was not original and that part of the parapet was false. Following a section on the restoration and framing, the author suggests possible explanations for the alterations that were found. There are illustrations of the panel before, during, and following cleaning and restoration, as well as an x-ray mosaic.
Coras, Brigitte; Landthaler, Michael; Stolz, Wilhelm; Vogt, Thomas
Site-specific histopathology features have been reported for acral, auricular, flexural, and genital melanocytic nevi, however, to the best of our knowledge, site- and sex-specific histology of dysplastic nevi on the lower leg (between knee and ankle) of women (DN-LW) has not been reported. In this retrospective histopathology study, we compared DN-LW (N = 42) with appropriate control groups of (1) DN of the lower leg of men (N = 20; DN-LM), (2) DN from the back of women (N = 20), (3) common nevi of the lower leg of women (N = 40), and (4) levels 1-2 superficial spreading melanoma of the lower leg of women (N = 20). Compared with dysplastic nevi on the back, DN-LW were smaller in diameter and exhibited a significantly higher score for pagetoid spread (P nevus (54% in DN-LW vs. 15% in DN-LM). As with other body sites, the dermatopathologist should be aware that dysplastic nevi occurring on the lower leg in women have site- and sex-specific features. Knowing this profile may lower the risk of misdiagnosing DN-LW and melanoma of the lower leg of women.
Vallone, María Gabriela; Tell-Marti, Gemma; Potrony, Miriam; Rebollo-Morell, Aida; Badenas, Celia; Puig-Butille, Joan Anton; Gimenez-Xavier, Pol; Carrera, Cristina; Malvehy, Josep; Puig, Susana
The melanocortin 1 receptor (MC1R) is a highly polymorphic gene. The loss-of-function MC1R variants ("R") have been strongly associated with red hair color phenotype and an increased melanoma risk. We sequenced the MC1R gene in 175 healthy individuals to assess the influence of MC1R on nevus phenotype. We identified that MC1R variant carriers had larger nevi both on the back [p-value = .016, adjusted for multiple parameters (adj. p-value)] and on the upper limbs (adj. p-value = .007). Specifically, we identified a positive association between the "R" MC1R variants and visible vessels in nevi [p-value = .033, corrected using the FDR method for multiple comparisons (corrected p-value)], dots and globules in nevi (corrected p-value = .033), nevi with eccentric hyperpigmentation (corrected p-value = .033), a high degree of freckling (adj. p-value = .019), and an associative trend with presence of blue nevi (corrected p-value = .120). In conclusion, the MC1R gene appears to influence the nevus phenotype. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Bergman, R; Azzam, H; Sprecher, E; Manov, L; Munichor, M; Friedman-Birnbaum, R; Ben-Itzhak, O
The histopathologic differential diagnosis of Spitz nevus (SN) from malignant melanoma (MM) may be difficult. We attempted to elucidate the pattern of expression of a newly recognized melanocyte-specific melanosomal protein MART-1 in routinely processed specimens of SNs, MMs, and ordinary melanocytic nevi (MNs) and to see whether it can help to differentiate between them. Twenty SN, 22 MM, and 27 ordinary MN were immunostained with anti-MART-1 monoclonal antibody (clone A103). All SNs, MNs, and MMs demonstrated cytoplasmic staining for MART-1 in some of their tumor cells, of which 17 of 20 (85%) and 24 of 27 (89%) of SN and MN, respectively, demonstrated positive stainings in more than half of their tumor cells, as compared with only 10 of 22 (45%) of the MM (P <.05). The majority of lesions in all 3 types of tumors showed a homogeneous mode of staining, although MM tended to show a more heterogeneous pattern. A consistent pattern of stratification of staining with progressive descent into the dermis was not demonstrated in these tumors. MART-1 does not differentiate between SN, MM, and ordinary MN in a consistent pattern, but it may be used as a marker for these tumors.
Matthew G Hanna
Full Text Available Background: The diagnosis of malignant melanoma (MM is among the diagnostic challenges pathologists encounter on a routine basis. Melanoma may arise in patients with preexisting dysplastic nevi (DN and it is still the cause of 1.7% of all cancer-related deaths. Melanomas often have overlapping histological features with DN, especially those with severe dysplasia. Nucleotyping for identifying nuclear textural features can analyze nuclear DNA structure and organization. The aim of this study is to differentiate MM and DN using these methodologies. Methods: Dermatopathology slides diagnosed as MM and DN were retrieved. The glass slides were scanned using an Aperio ScanScopeXT at ×40 (0.25 μ/pixel. Whole slide images (WSI were annotated for nuclei selection. Nuclear features to distinguish between MM and DN based on chromatin distributions were extracted from the WSI. The morphological characteristics for each nucleus were quantified with the optimal transport-based linear embedding in the continuous domain. Label predictions for individual cell nucleus are achieved through a modified version of linear discriminant analysis, coupled with the k-nearest neighbor classifier. Label for an unknown patient was set by the voting strategy with its pertaining cell nuclei. Results: Nucleotyping of 139 patient cases of melanoma (n = 67 and DN (n = 72 showed that our method had superior classification accuracy of 81.29%. This is a 6.4% gain in differentiating MM and DN, compared with numerical feature-based method. The distribution differences in nuclei morphology between MM and DN can be visualized with biological interpretation. Conclusions: Nucleotyping using quantitative and qualitative analyses may provide enough information for differentiating MM from DN using pixel image data. Our method to segment cell nuclei may offer a practical and inexpensive solution in aiding in the accurate diagnosis of melanoma.
Hanna, Matthew G; Liu, Chi; Rohde, Gustavo K; Singh, Rajendra
The diagnosis of malignant melanoma (MM) is among the diagnostic challenges pathologists encounter on a routine basis. Melanoma may arise in patients with preexisting dysplastic nevi (DN) and it is still the cause of 1.7% of all cancer-related deaths. Melanomas often have overlapping histological features with DN, especially those with severe dysplasia. Nucleotyping for identifying nuclear textural features can analyze nuclear DNA structure and organization. The aim of this study is to differentiate MM and DN using these methodologies. Dermatopathology slides diagnosed as MM and DN were retrieved. The glass slides were scanned using an Aperio ScanScopeXT at ×40 (0.25 μ/pixel). Whole slide images (WSI) were annotated for nuclei selection. Nuclear features to distinguish between MM and DN based on chromatin distributions were extracted from the WSI. The morphological characteristics for each nucleus were quantified with the optimal transport-based linear embedding in the continuous domain. Label predictions for individual cell nucleus are achieved through a modified version of linear discriminant analysis, coupled with the k-nearest neighbor classifier. Label for an unknown patient was set by the voting strategy with its pertaining cell nuclei. Nucleotyping of 139 patient cases of melanoma ( n = 67) and DN ( n = 72) showed that our method had superior classification accuracy of 81.29%. This is a 6.4% gain in differentiating MM and DN, compared with numerical feature-based method. The distribution differences in nuclei morphology between MM and DN can be visualized with biological interpretation. Nucleotyping using quantitative and qualitative analyses may provide enough information for differentiating MM from DN using pixel image data. Our method to segment cell nuclei may offer a practical and inexpensive solution in aiding in the accurate diagnosis of melanoma.
Kelly, Patrick J.; Xu, Chuanling; Lucas, Helene; Loftis, Amanda; Abete, Jamie; Zeoli, Frank; Stevens, Audrey; Jaegersen, Kirsten; Ackerson, Kate; Gessner, April; Kaltenboeck, Bernhard; Wang, Chengming
Background Although tick-borne diseases are important causes of morbidity and mortality in dogs in tropical areas, there is little information on the agents causing these infections in the Caribbean. Methodology We used PCRs to test blood from a cross-section of dogs on St Kitts for Ehrlichia (E.) canis, Babesia (B.) spp., Anaplasma (A.) spp. and Hepatozoon (H.) spp. Antibodies against E. canis and A. phagocytophilum/platys were detected using commercial immunochromatography tests. Records of the dogs were examined retrospectively to obtain clinical and laboratory data. Principal findings There was serological and/or PCR evidence of infections of dogs with E. canis (27%; 46/170), Babesia spp. (24%; 90/372) including B. canis vogeli (12%; 43/372) and B. gibsoni (10%; 36/372), A. platys (11%; 17/157) and H. canis (6%; 15/266). We could not identify the Babesia sp. detected in nine dogs. There was evidence of multiple infections with dual infections with E. canis and B. canis vogeli (8%; 14/179) or B. gibsoni (7%; 11/170) being the most common. There was agreement between immunochromatography and PCR test results for E. canis for 87% of dogs. Only 13% of exposed dogs had signs of a tick-borne disease and 38% had laboratory abnormalities. All 10 dogs presenting for a recheck after treatment of E. canis with doxycycline were apparently healthy although all remained seropositive and six still had laboratory abnormalities despite an average of two treatments with the most recent being around 12 months previously. Infections with Babesia spp. were also mainly subclinical with only 6% (4/67) showing clinical signs and 13% (9/67) having laboratory abnormalities. Similarly, animals with evidence of infections with A. platys and H. canis were largely apparently healthy with only occasional laboratory abnormalities. Conclusions Dogs are commonly infected with tick-borne pathogens in the Caribbean with most having no clinical signs or laboratory abnormalities. PMID:23335965
Veierød, Marit Bragelien; Adami, Hans-Olov; Lund, Eiliv; Armstrong, Bruce Konrad; Weiderpass, Elisabete
Few prospective studies have analyzed solar and artificial (solarium) UV exposure and melanoma risk. We investigated these associations in a Norwegian-Swedish cohort study and addressed effect modification by age, pigmentary characteristics, and nevi. The cohort included women ages 30 to 50 years at enrollment from 1991 to 1992. Host factors and exposure to sun and solariums in life decades were collected by questionnaire at enrollment. Relative risks (RR) with 95% confidence intervals (CI) were estimated by Poisson regression. Among 106,366 women with complete follow-up through 2005, 412 melanoma cases were diagnosed. Hair color and large, asymmetric nevi on the legs were strongly associated with melanoma risk (P(trend) or =2 nevi increased from brown/black to blond/yellow to red-haired women (RRs, 1.72, 3.30, and 4.95, respectively; P(interaction) = 0.18). Melanoma risk increased significantly with the number of sunburns and bathing vacations in the first three age decades (P(trend) or =1 time/mo 1.49 (95% CI, 1.11-2.00) and 1.61 (95% CI 1.10-2.35), respectively; P(trend) color identify people with red hair and multiple nevi as a very high risk group and suggest important gene-gene interactions involving MC1R in melanoma etiology.
Saint Kitts and Nevis Bermuda Hong Kong Saint Lucia Bhutan Iceland Saint Pierre and Miquelon Bosnia and Herzegovina Jamaica Saint Vincent/Grenadines...Barbuda Guam Paraguay Armenia Guinea Portugal Aruba Guinea-Bissau Puerto Rico Bahamas, The Guyana Reunion Belgium Haiti Saint Helena Belize Honduras
Park, Hye-Sang; Park, Chan-Hyuk; Choi, Bo-Ra; Lim, Mi-Sun; Heo, Su-Hak; Kim, Cheol-Hann; Kang, Sang-Gue; Whang, Kyu U; Cho, Moon K
Heat shock proteins (HSPs) restore immature proteins or denatured proteins, thus protecting cells. Also, the expression of some HSPs is elevated substantially in malignant tumors, but the expression of HSPs in association with melanoma has yet to be studied. Therefore, we examined the expression patterns of HSP 70 and 105 in melanoma, benign melanocytic nevi and normal human skin. Two specimens of malignant melanoma, two of benign melanocytic nevi and six of normal human skin were analyzed using Western blot analysis for expression of HSP 70 and 105. In another set, 16 specimens of malignant melanoma, 24 of benign melanocytic nevi and eight of normal human skin were analyzed for the expression of HSP 105 using immunohistochemical studies. The Western blot analysis showed that HSP 70 was overexpressed in all three types. But, the HSP 105 was hardly expressed in normal human skin and benign melanocytic nevi. However, in malignant melanoma, the HSP 105 was overexpressed, and immunohistochemical examination of HSP 105 showed a result similar to that of Western blot analysis. In our study, HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70.
Grevelink, JM; vanLeeuwen, RL; Anderson, RR; Byers, HR
Background: Laser irradiation of congenital melanocytic nevi is a controversial treatment. Recurrence of lesions after laser treatment appears to be the rule, and the effects of laser irradiation on cellular biological behavior and the possible mutagenic responses of nevomelanocytes that have
Vallabh, N A; Sahni, J N; Parkes, C K; Czanner, G; Heimann, H; Damato, B
PurposeTo report near-infrared reflectance (NIR-R), near-infrared autofluorescence (NIR-AF) and blue wave autofluorescence (BW-AF) appearance of choroidal nevi using a confocal scanning laser ophthalmoscope (cSLO).Patients and methodsNIR-R, NIR-AF and BW-AF images of choroidal nevi were compared with color fundus photos (CF). Images were graded as hyperreflective if reflectance was much greater than background, hyporeflective if less than background, and isoreflective if the same as the background.ResultsForty-two nevi of 39 patients were imaged. When compared with CF, nevi could be identified on 95% (40/42) NIR-R images (95% CI: 83.5-99.3). On NIR-R 71% (30/42) demonstrated hyperreflectance and 24% (10/42) were hyporeflective. Hyperreflectivity was demonstrated in 96% (23/24) of NIR-AF images (95% CI: 79.1-99.9) and 34% (14/41) of BW-AF images (95% CI: 20.0-50.5). On NIR-R, 29/40 (73%) were apparently smaller in comparison with CF and 11/40 (28%) had the same area. A correlation was found between NIR-R and NIR-AF (P=0.02) but not with BW-AF (P=0.15).ConclusionsNevi can be visualized well using NIR-R and NIR-AF imaging modalities, but are less frequently visible using BW-AF. These changes may be related to melanin within the choroid or chronic changes of the overlying retinal pigment epithelium.
Notice of Proposed Assessment of Class II Civil Penalty and Notice of Opportunity for Hearing under Sections 309(g) and 311(b)(6) of the Clean Water Act for Saint-Gobain Abrasives, Inc. and Saint-Gobain Ceramics & Plastics, Inc., CWA-01-2016-0057
Peter B. Gray
Full Text Available We investigated body image in St. Kitts, a Caribbean island where tourism, international media, and relatively high levels of body fat are common. Participants were men and women recruited from St. Kitts (n = 39 and, for comparison, U.S. samples from universities (n = 618 and the Internet (n = 438. Participants were shown computer generated images varying in apparent body fat level and muscularity or breast size and they indicated their body type preferences and attitudes. Overall, there were only modest differences in body type preferences between St. Kitts and the Internet sample, with the St. Kitts participants being somewhat more likely to value heavier women. Notably, however, men and women from St. Kitts were more likely to idealize smaller breasts than participants in the U.S. samples. Attitudes regarding muscularity were generally similar across samples. This study provides one of the few investigations of body preferences in the Caribbean.
National Oceanic and Atmospheric Administration, Department of Commerce — Bathymetry of Lake Erie and Lake Saint Clair has been compiled as a component of a NOAA project to rescue Great Lakes lake floor geological and geophysical data and...
Rohner, Ronald P.; And Others
Structural equation modeling analysis of 349 youths, aged 9-16, in St. Kitts, West Indies, showed that physical punishment by itself does make a modest, but significant, direct and negative contribution to youths' psychological adjustment. Children tended to experience themselves to be rejected in direct proportion to the frequency and severity of…
... Pakistan, Palau, Palestine, State of, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Poland, Portugal, Puerto Rico, Qatar, Romania, Russian Federation, Rwanda, Saint Bartelemey, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia ...
Holst, Line Marie Broksø; Kaczkowski, Bogumil; Glud, Martin
MicroRNAs (miRNAs) are small non-coding RNAs, which regulate gene expression through base pairing with mRNA and which are crucially involved in carcinogenesis (the so-called oncomiRs). We compared the miRNA signature between acquired melanocytic nevi showing clinical atypia (atypic nevi, AN......) and common acquired nevi (common nevi, CN). We obtained miRNA profiles from 41 biopsies (22 AN and 19 CN) and showed that AN could be differentiated from CN on the basis of the expression of 36 miRNAs (false discovery rate...
Khondzinskii Pavel, archpriest
Full Text Available The unique place which holds St. Augustine in the Western tradition make us to pay attention to the reception of his heritage in the Russian theology, that was sometimes so close to the western one. That why we examine the correlation between his ideas and the thought of the famous Russian theologian St. Philaret of Moscow. There we provide the correlation in thiadology, ecclesiology, in the doctrine of the pure love, in the relation to the grace and freedom. Our research let us to conclude that the correlation between these saint fathers was a rather complex phenomena. But we can witness that St. Augustine’s theology inﬂuenced St. Philaret. In the domain of triadology Augustine serves as a basis for his own thought. In the Doctrine of the Grace St. Philaret retain the “anthropological pessimism” characteristic for St. Augustine but tends to avoid the extremity of his position. St. Philaret also softens Augustine’s doctrine of the “pure love” and concentrates on the suﬀering as a testimony of its unselﬁ shness. The closest point in their heritage is a doctrine of the boarders of the Church, but St. Philaret uses diﬀerent argumentation while defends the same theses. We may interpret their acknowledgement of these theses (with diﬀerent argumentation as an evidence of its truly patristic character.
Full Text Available Academic literature until now has ignored the possibility of seeing the roots of Dostoevsky’s idea of a God-bearing people in the Saint Dimitri of Rostov’s conception of the passion bearer. But, on the contrary, obvious parallels between the two permit the author to speak of a deliberate coincidence. On the other hand, the two are divided in their conceptions of the reasons for human suffering
Smith, Jennifer H; Padnick-Silver, Lissa; Newlin, Anna; Rhodes, Katrina; Rubinstein, Wendy S
To evaluate a kindred with familial uveal and cutaneous melanoma and to identify potential genetic and environmental factors that may predispose individuals to develop uveal melanoma. Family-based case report with detailed clinical and genetic evaluation. Ten siblings in a single nuclear family. Evaluation of a large sibship via family history, complete eye and skin examinations, environmental risk factor questionnaire, and genetic testing, as well as a MEDLINE search of familial uveal melanoma kindreds. Cutaneous and ocular nevi, benign and malignant neoplasms of skin and other sites, brief skin cancer risk assessment tool risk classification for cutaneous melanoma, DNA sequencing of p16INK4a and p14ARF genes, and citations on familial uveal melanoma. The proband and his mother had uveal melanoma, 3 cutaneous melanomas occurred among 2 siblings, and 2 other siblings had basal cell carcinomas. No germline mutations were detected in the melanoma-associated tumor suppressor genes p16INK4a and p14ARF. Seven out of 10 siblings had a history of cutaneous and/or ocular nevi. Of the 3 subjects without nevi, 2 had histories of eye or skin malignancies (1 uveal melanoma, 1 basal cell carcinoma). Three of the 10 siblings had relevant ocular findings (2 choroidal nevi, 1 uveal melanoma). Six were also found to be in the "high-risk" classification for cutaneous malignancies based on scores from a previously validated risk assessment tool. This family, combined with the 91 previously reported familial uveal melanoma kindreds, brings to 92 the total number thus far recorded. Our results strengthen the association between uveal melanoma, atypical nevi, and cutaneous melanoma. This relationship supports the recommendation that individuals with a personal or family history of uveal melanoma, particularly in combination with atypical nevi, should be regularly screened for uveal and cutaneous melanoma.
Saint Sampson, whose feast is celebrated on June 27, was depicted among holy physicians. However, his images were not frequent. He was usually accompanied with Saint Mokios (in Saint Sophia in Kiev, the Transfiguration church in the Mirozh monastery and the church of the Presentation of the Holy Virgin in the Temple in the monastery of Saint Euphrosyne; possibly also in Saint Panteleimon in Nerezi and Saint Demetrios in the village of Aiani near Kozani; fur...
Nasti, Tahseen H.; Cochran, J. Barry; Tsuruta, Yuko; Yusuf, Nabiha; McKay, Kristopher M.; Athar, Mohammad; Elmets, Craig A.
Acquired melanocytic nevi are commonly found in sun exposed and unexposed human skin, but the potential for their transformation into invasive melanoma is not clear. Therefore, a mouse model of nevus initiation and progression was developed in C3H/HeN mice using a modified chemical carcinogenesis protocol. Nevi develop due to DNA damage initiated by dimethylbenz(a) anthracene (DMBA) followed by chronic promotion with 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA). Dysplastic pigmented skin lesions appeared in 7–9 wk with 100% penetrance. Nests of melanocytic cells appeared in a subset of skin draining lymph nodes (dLN) by 25 wk, but not in age matched controls. Immunohistochemistry, real‐time PCR, and flow cytometric analyses confirmed their melanocytic origin. Transformed cells were present in a subset of nevi and dLNs, which exhibited anchorage‐independent growth, tumor development, and metastasis in nude mice. Approximately 50% of the cell lines contained H‐Ras mutations and lost tumor suppressor p16Ink4a expression. While most studies of melanoma focus on tumor progression in transgenic mouse models where the mutations are present from birth, our model permits investigation of acquired mutations at the earliest stages of nevus initiation and promotion of nevus cell transformation. This robust nevus/melanoma model may prove useful for identifying genetic loci associated with nevus formation, novel oncogenic pathways, tumor targets for immune‐prevention, screening therapeutics, and elucidating mechanisms of immune surveillance and immune evasion. © 2015 The Authors. Molecular Carcinogenesis, published by Wiley Periodicals, Inc. PMID:25788145
Nasti, Tahseen H; Cochran, J Barry; Tsuruta, Yuko; Yusuf, Nabiha; McKay, Kristopher M; Athar, Mohammad; Timares, Laura; Elmets, Craig A
Acquired melanocytic nevi are commonly found in sun exposed and unexposed human skin, but the potential for their transformation into invasive melanoma is not clear. Therefore, a mouse model of nevus initiation and progression was developed in C3H/HeN mice using a modified chemical carcinogenesis protocol. Nevi develop due to DNA damage initiated by dimethylbenz(a) anthracene (DMBA) followed by chronic promotion with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Dysplastic pigmented skin lesions appeared in 7-9 wk with 100% penetrance. Nests of melanocytic cells appeared in a subset of skin draining lymph nodes (dLN) by 25 wk, but not in age matched controls. Immunohistochemistry, real-time PCR, and flow cytometric analyses confirmed their melanocytic origin. Transformed cells were present in a subset of nevi and dLNs, which exhibited anchorage-independent growth, tumor development, and metastasis in nude mice. Approximately 50% of the cell lines contained H-Ras mutations and lost tumor suppressor p16(Ink4a) expression. While most studies of melanoma focus on tumor progression in transgenic mouse models where the mutations are present from birth, our model permits investigation of acquired mutations at the earliest stages of nevus initiation and promotion of nevus cell transformation. This robust nevus/melanoma model may prove useful for identifying genetic loci associated with nevus formation, novel oncogenic pathways, tumor targets for immune-prevention, screening therapeutics, and elucidating mechanisms of immune surveillance and immune evasion. © 2015 The Authors. Molecular Carcinogenesis, published by Wiley Periodicals, Inc.
Kim, Caroline C; Swetter, Susan M; Curiel-Lewandrowski, Clara; Grichnik, James M; Grossman, Douglas; Halpern, Allan C; Kirkwood, John M; Leachman, Sancy A; Marghoob, Ashfaq A; Ming, Michael E; Nelson, Kelly C; Veledar, Emir; Venna, Suraj S; Chen, Suephy C
The management of clinically atypical nevi/dysplastic nevi (CAN/DN) is controversial, with few data to guide the process. Management recommendations for DN with positive histologic margins were developed by the Delphi method to achieve consensus among members of the Pigmented Lesion Subcommittee (PLS) of the Melanoma Prevention Working Group (MPWG) after reviewing the current evidence. To outline key issues related to the management of CAN/DN: (1) biopsies of CAN and how positive margins arise, (2) whether incompletely excised DN evolve into melanoma, (3) current data on the outcomes of DN with positive histologic margins, (4) consensus recommendations, and (5) a proposal for future studies, including a large-scale study to help guide the management of DN with positive margins. The literature, including recent studies examining management and outcomes of DN with positive margins between 2009 to 2014, was reviewed. A consensus statement by the PLS of the MPWG following review of the literature, group discussions, and a structured Delphi method consensus. This consensus statement reviews the complexities of management of CAN/DN. A review of the literature and 2 rounds of a structured Delphi consensus resulted in the following recommendations: (1) mildly and moderately DN with clear margins do not need to be reexcised, (2) mildly DN biopsied with positive histologic margins without clinical residual pigmentation may be safely observed rather than reexcised, and (3) observation may be a reasonable option for management of moderately DN with positive histologic margins without clinically apparent residual pigmentation; however, more data are needed to make definitive recommendations in this clinical scenario.
McKittrick, T R; Jacobsen, K H
To examine the relationship between infrequent toothbrushing and infrequent handwashing among middle school students from 15 Latin American and Caribbean countries (Antigua and Barbuda, Argentina, British Virgin Islands, Cayman Islands, Costa Rica, Grenada, Guatemala, Guyana, Peru, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and Grenadines, Suriname, Trinidad and Tobago, and Uruguay). A secondary analysis was done of nationally-representative data from 33 174 middle school students who participated in the Global School-based Student Health Survey (GSHS) between 2006 and 2011. In all 15 countries, the association between rarely brushing or cleaning teeth and rarely handwashing after using the toilet was significant for both boys and girls. The pooled odds ratio for this association was 6.7 (5.8, 7.7). Healthcare providers who notice signs of poor dental hygiene or infrequent bathing in adolescents should consider providing comprehensive hygiene education to their patients, since infrequent oral and body hygiene behaviours tend to co-exist and both are threats to health.
Hossain, Deloar; Qian, Junqi; Adupe, Joy; Drewnowska, Krystyna; Bostwick, David G
Malignant melanoma is sometimes difficult to distinguish from benign nevus, and ancillary confirmatory studies would be of value in selected cases. To accurately differentiate melanoma from benign nevus, we investigated the utility of chromosomal anomalies in skin biopsy specimens using multitargeted fluorescence in-situ hybridization (FISH). Skin biopsy specimens were retrospectively collected from 63 patients diagnosed with benign compound nevus (n=32) or malignant melanoma (n=31); each diagnosis was independently confirmed before study by a second dermatopathologist. Unstained tissue sections were hybridized for 30 min using fluorescence-labeled oligo-DNA probes for chromosomes 6, 7, 11, and 20. Fluorescent signals for each chromosome were enumerated in 30 cells per case. Numeric chromosomal anomalies were found in 0% (0 of 32) of normal epidermis, 6% (two of 32) of compound nevi, and 94% (29 of 31) of melanomas (nevus vs. melanoma, Pmelanoma specimens, significantly higher than that in compound nevi (Pmelanoma was gain of chromosome 11, followed consecutively by gains of chromosomes 7, 20, and 6. Chromosomal anomalies detected by FISH had an overall sensitivity of 94% and specificity of 94% in the separation of nevus and melanoma. With the use of oligo-DNA probes, multitargeted FISH directed against chromosomes 6, 7, 11, and 20 is highly sensitive and specific for separation of nevus and melanoma. Unlike other traditional FISH probes, oligo-DNA probes required shorter hybridization time, allowing faster diagnostic evaluation.
Maximov, G; Chokoeva, A; Philipov, S; Cardoso, J; Ivanov, G; Wollina, U; Tchernev, G
We describe a rare case of a 28 year-old male patient presenting with pruritus and increased sensitivity of the prepuce accompanied by erythematous confluent papules, unilateral nevus flammeus (NF) along almost the whole length of the right lower limb and two dysplastic nevi (DN), one located on the mid back and the other on the medial border of the right fifth toe, the latter coinciding with the NF. A biopsy of the prepuce revealed lichen sclerosus et atrophicus (LSA). Mental health assessment revealed anxiety disorder and predisposition to panic attacks. Several clinical, paraclinical and histopathological examinations were undertaken to evaluate potential underlying factors for such unusual combination of findings. Both dysplastic nevi were surgically removed. A topical calcineurin inhibitor treatment of the LSA was prescribed. For the first time in medical literature, we report an extremely rare association of NF, DN (including DN over NF) and LSA, and we are focusing our discussion on a potentially common genetic background which could explain this unusual combination of different diseases, which could in turn be caused by different mutations in common genes and/or different genes with close location in the genome.
Taloni, Alessandro; Alemi, Alexander; Ciusani, Emilio; Sethna, James P.; Zapperi, Stefano; La Porta, Caterina A. M.; National Research Council Of Italy Team; Lassp, Department Of Physics, Cornell University Team; Istituto Neurologico Carlo Besta Collaboration; Department Of Biosciences, University Of Milano Team
Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view. Diagnostic and prognostic tools are then mostly based on dermoscopic examination and morphological analysis of histological tissues. To investigate the role of mechanics and geometry in the morpholgical dynamics of melanocytic nevi, we present a computational model for cell proliferation in a layered non-linear elastic tissue. Our simulations show that the morphology of the nevus is correlated to the initial location of the proliferating cell starting the growth process and to the mechanical properties of the tissue. We also demonstrate that melanocytes are subject to compressive stresses that fluctuate widely in the nevus and depend on the growth stage. Numerical simulations of cells in the epidermis releasing matrix metalloproteinases display an accelerated invasion of the dermis by destroying the basal membrane. Moreover, we show experimentally that osmotic stress and collagen inhibit growth in primary melanoma cells while the effect is much weaker in metastatic cells.
Situm, Mirna; Bolanca, Zeljana; Kolić, Maja; Gulin, Sanda Jerković; Gulin, Damir
The aim of the study was to analyze the clinical prevalence and pathohistological correlation of dysplastic nevi. In the period between 2000 and 2009, in the Outpatient Clinic of Referral Centre for Melanoma of the Ministry of Health and Social Welfare of the Republic of Croatia, 12,344 patients were examined, and 35.07% of them were surgically removed in the same institution. Among the patients, 69.16% had clinically diagnosed melanocytic tumor. Out of them, 28.39% were dysplastic. Dysplastic nevus was pathohistologically diagnosed in 20.02% of pathohistologically diagnosed melanocytic tumors. There was women predominace among patients with clinically diagnosed dysplastic nevi (65.22%). The most frequent localization was the trunk in both sexes, women 78.18%, men 76.75%. The coincidence of clinical and pathohistological diagnosis of dysplastic nevus was 30.70%. The results of this study, based on a large number of patients could be a significant contribution in understanding characteristics of dysplastic nevus, its clinical and pathohistological complexity. We hope that the data will contribute to the creation of general accepted protocols in the diagnostics of dysplastic nevus.
Důra, Miroslav; Němejcová, Kristýna; Jakša, Radek; Bártů, Michaela; Kodet, Ondřej; Tichá, Ivana; Michálková, Romana; Dundr, Pavel
The glucose transporter-1 (Glut-1) is a cell membrane glycoprotein involved in glucose uptake. An increased expression of Glut-1 is an important cell adaptation mechanism against hypoxia. An upregulation of Glut-1 can be found in several types of malignant tumors, which are able to reprogram their metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect). However, the data regarding melanocytic lesions is equivocal. We performed comprehensive immunohistochemical analysis of the Glut-1 expression in 225 malignant melanomas (MM) and 175 benign nevi. Only the membranous expression of Glut-1 was regarded as positive. The expression of Glut-1 (the cut-off for positivity was determined as H-score 15) was found in 69/225 malignant melanomas. The number of positive cases and the H-score of Glut-1 increased where there was a higher Breslow thickness (p Glut-1 is a common feature of a malignant melanoma but this type of expression is very rare in benign melanocytic nevi. Our results suggest that the membranous expression of Glut-1 can be used as a surrogate marker in the assessing of the biological nature of benign and malignant melanocytic lesions. However, despite its high specificity, the sensitivity of this marker is relatively low. Moreover, due to the fact that the increased expression of Glut-1 correlates with a shorter survival period (10-year disease free survival, recurrence free survival and metastasis free survival and MFS), it can be used as a prognostically adverse factor.
Using historic documents of the Church of Jesus Christ of Latter-day Saints (LDS) and resources of its leaders, the principles of LDS or Mormon education and its key characteristics are described. In particular, the following characteristics are discussed: (1) the critical role of the Spirit in both teaching and learning, (2) the worthiness,…
Methods: Retrospective review of 840 records of patients admitted to medical ward of Saint Paul hospital during. April 1, 2012-March 31, .... permission, records were reviewed since patient consent was not .... *Others: Bronchial asthma/COPD (2), Other CV disorders (3), other neurologic disorders (4),. Haematology and ...
Background: Globally, trends of medical admission have been changing. This study was carried out to assess the current trend of medical admissions and outcomes in Ethiopia. Methods: Retrospective review of 840 records of patients admitted to medical ward of Saint Paul hospital during April 1, 2012-March 31, 2013 was ...
Full Text Available Saint Symphorian’s church in Nuits-Saint-Georges (Burgundy, which dates from near 1220-1240, is situated during the transition of two architectural styles and attests a local but rather backward-looking Cistercian legacy that some Gothic urban and more innovative elements modernize. Moreover the church takes part, for the same reasons as those in Agencourt, Gerland and Prissey, in the surprising wave of reconstructions which denotes among others the important economic development of the country of Cîteaux at the beginning of the 13th century.
Ko, Jennifer S; Matharoo-Ball, Balwir; Billings, Steven D; Thomson, Brian J; Tang, Jean Y; Sarin, Kavita Y; Cai, Emily; Kim, Jinah; Rock, Colleen; Kimbrell, Hillary Z; Flake, Darl D; Warf, M Bryan; Nelson, Jonathan; Davis, Thaylon; Miller, Catherine; Rushton, Kristen; Hartman, Anne-Renee; Wenstrup, Richard J; Clarke, Loren E
Background: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes.Methods: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature. Cases were selected according to pre-defined clinical outcome measures. Malignant lesions were defined as stage I-III primary cutaneous melanomas that produced distant metastases (metastatic to sites other than proximal sentinel lymph node(s)) following diagnosis of the primary lesion. Melanomas that were metastatic at the time of diagnosis, all re-excisions, and lesions with Benign lesions were defined as cutaneous melanocytic lesions with no adverse long-term events reported.Results: Of 239 submitted samples, 182 met inclusion criteria and produced a valid gene expression result. This included 99 primary cutaneous melanomas with proven distant metastases and 83 melanocytic nevi. Median time to melanoma metastasis was 18 months. Median follow-up time for nevi was 74.9 months. The gene expression score differentiated melanoma from nevi with a sensitivity of 93.8% and a specificity of 96.2%.Conclusions: The results of gene expression testing closely correlate with long-term clinical outcomes of patients with melanocytic neoplasms.Impact: Collectively, this provides strong evidence that the gene signature adds valuable adjunctive information to aid in the accurate diagnosis of melanoma. Cancer Epidemiol Biomarkers Prev; 26(7); 1107-13. ©2017 AACR. ©2017 American Association for Cancer Research.
In recent years Kitt Peak National Observatory has undertaken a number of innovative projects to optimize science operations with the suite of telescopes we operate on Kitt Peak, Arizona. Changing scientific requirements and expectations of our users, evolving technology and declining budgets have motivated the changes. The operations improvements have included telescope performance enhancements--with the focus on the Mayall 4-m--modes of observing and scheduling, telescope control and observing systems, planning and communication, and data archiving.
Speeckaert, Reinhart; van Geel, Nanja; Luiten, Rosalie M; van Gele, Mireille; Speeckaert, Marijn; Lambert, Jo; Vermaelen, Karim; Tjin, Esther P M; Brochez, Lieve
Regressing nevi are considered an example of an efficient early antitumoral response preventing the development of neoplasia. The underlying mechanism has not been elucidated, although an immune-based destruction of melanocytes is supposed. The aim of this study was to provide evidence of an effective immunosurveillance of pigment lesions in a patient at high risk of melanoma. A patient with the dysplastic nevus syndrome and a history of melanoma was included in this study. Since 2003, a marked regression of almost all nevi was observed. Immunohistochemistry was performed and the antigen specificity of T-cells was analyzed on T-cells isolated from a regressing nevus by flow cytometry using HLA-A2-peptide tetramers containing Mart-1(26-35), gp100(280-288), gp100(209-217) and tyrosinase(369-377). Immunohistochemistry of the regressing nevi showed a strong infiltrate of CD4 + and CD8 + T-cells. Flow cytometric analyses demonstrated the presence of a CD8 + T-cell response against gp100(280-288) and Mart-1(26-35) both in peripheral blood and in a regressing nevus. These findings indicate that an immune reaction against melanocyte differentiation antigens can target specifically nevi without signs of vitiligo and suggests that boosting the anti-melanocyte immune response in patients at high risk for melanoma may prevent tumor development at an early stage.
... Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Self-Pay, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (Dutch part), Slovakia (Slovak Republic), Slovenia, Solomon Islands, Somalia, South Africa, South Sudan, Spain ...
... Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Self-Pay, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (Dutch part), Slovakia (Slovak Republic), Slovenia, Solomon Islands, Somalia, South Africa, South Sudan, Spain ...
... Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Self-Pay, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (Dutch part), Slovakia (Slovak Republic), Slovenia, Solomon Islands, Somalia, South Africa, South Sudan, Spain ...
CRIJNS, MB; BERGMAN, W; Berger, MJ; HERMANS, J; SOBER, AJ
Cutaneous melanoma may occur as isolated, so-called 'sporadic' cases or in association with multiple atyical naevi and in familial clusters, in which case it is referred to as the familial dysplastic naevus syndrome (DNS). In this retrospective study (a) the number and body distribution of
Troyanova, P.; Borisova, E.; Stoyanova, V.; Avramov, L.
The easy and non-destructive fluorescence method for quantification of early changes in biological tissues improves the possibilities of the clinical research. Using endogenous and exogenous fluorophores one can achieve high accuracy in the determination of malignant melanoma lesions with wide clinical applications. The goals of this work were investigation of melanin-pigmented cutaneous lesions by the methods of laser-induced autofluorescence spectroscopy (LIAFS), using nitrogen laser (337 nm) as excitation source. All lesions investigated were excised and investigated histologically by standard methods and histological results were used for comparison with the spectra detected. In the cases of nevi and melanoma significant decrease of fluorescence intensity toward normal skin fluorescence, which correlated with the type of pigment lesion was observed. The results, obtained in this investigation of the different pigment lesions could be used for better comprehension of the skin optical properties. The fluorescence spectroscopy of the human skin is very prominent for early diagnosis and differentiation of cutaneous diseases.
Fatma Pelin Cengiz
Full Text Available Congenital melanocytic nevi (CMN are visible pigmented lesions in the skin that are present at birth. CMN are benign malformations resulting from defective development of melanocyte precursors in the embryo. Six MMs from six patients were analyzed by clinical and dermoscopic examination. Of the patients, 33.3% were female (N = 2 and 66.6% were male (N = 4. Of the MMs, four (66.6% were superficial spreading MM and two (33.3 % were in situ MM. A reticular pattern was present in the MMs of three patients (50%, a homogeneous pattern was present in the other patients (50% at the base of the MMs. Superficial spreading melanomas and in situ melanomas with atypical dots and globules and a blue-white veil were the most common dermoscopic features of MMs found in CMN.
Myler, Cory John
Existing research has revealed a robust relationship between high religiosity and negative attitudes towards sexual minorities. To date, however, there have been few studies investigating this relationship within the membership of The Church of Jesus Christ of Latter-day Saints (the LDS Church). The unique history, doctrine, and organization of this religion, along with its large size, rapid growth, and sizable influence, indicate that a study of homophobia among church members will provide a...
Voropaev V. A.
Full Text Available The article tells the history of St. Nicholas Church in Dykanka and its holy image of Saint Nicholas, examines some details of the Gogol family life, the legend of Maria Gogol-Yanovskaya's marriage and her oath in front of the Holy Saint icon.
Voropaev V. A.
The article tells the history of St. Nicholas Church in Dykanka and its holy image of Saint Nicholas, examines some details of the Gogol family life, the legend of Maria Gogol-Yanovskaya's marriage and her oath in front of the Holy Saint icon.
Full Text Available The Saint Peter and Saint Paul Archipelago in the central tropical Atlantic, is an important ground of whale sharks that are commonly sighted throughout the year close to the fishing boats in the adjacencies of the islands. In sightings reported between February 2000 and November 2005, the lengths of the individuals ranged between 1.8 to 14.0 m. The causes of these concentrations in the archipelago are still unclear, once there are no upwellings and plankton concentrations for feeding, and no reproductive activities were reported. Nevertheless, they could be associated to the spawning period of the abundant flying fishes, mainly in the first semester, when sightings were more frequent.
Jason Ezra Hawkes
Full Text Available Approximately 10% of melanoma cases are familial, but only 25-40% of familial melanoma cases can be attributed to germ-line mutations in the CDKN2A - the most significant high-risk melanoma susceptibility locus identified to date. The pathogenic mutation(s in most of the remaining familial melanoma pedigrees have not yet been identified. The most common mutations in nevi and sporadic melanoma are found in BRAF and NRAS, both of which result in constitutive activation of the MAPK pathway. However, these mutations are not found in uveal melanomas or the intradermal melanocytic proliferations known as blue nevi. Rather, multiple studies report a strong association between these lesions and somatic mutations in Guanine nucleotide-binding protein G(q subunit alpha (GNAQ, Guanine nucleotide-binding protein G(q subunit alpha-11 (GNA11 and BRCA1 associated protein-1 (BAP1. Recently, germ-line mutations in BAP1, the gene encoding a tumor suppressing deubiquitinating enzyme, have been associated with predisposition to a variety of cancers including uveal melanoma, but no studies have examined the association of germ-line mutations in GNAQ and GNA11 with uveal melanoma and blue nevi. We have now done so by sequencing exon 5 of both of these genes in 13 unique familial melanoma pedigrees, members of which have had either uveal or cutaneous melanoma and/or blue nevi. Germ-line DNA from a total of 22 individuals was used for sequencing; however no deleterious mutations were detected. Nevertheless, such candidate gene studies and the discovery of novel germ-line mutations associated with an increased MM susceptibility can lead to a better understanding of the pathways involved in melanocyte transformation, formulation of risk assessment, and the development of specific drug therapies.
Zemelman D, Viviana; Molina C, Paula; Valenzuela, Carlos Y; Honeyman M, Juan
There is an increase in the incidence of malignant melanoma in Chile. Previous studies have shown that the density and size of acquired melanocytic nevi (AMN) are a risk factor for developing malignant melanoma. To assess the number and anatomical distribution of acquired melanocytic nevi in Chilean adolescents. The number of AMN was counted in 30 anatomical sites in 201 Chilean school children (111 females), aged from 11 to 15 years. The number of small AMN (2-4.9 mm) and large AMN (>5 mm of diameter) was determined. Mean AMN number per person was 32.7 (95% confidence interval (CI) 30.7-42.3) in males and 29 (95% CI 271-38.6) in females (p =NS). Males had a higher number of AMN in the face, neck and trunk. Females had a higher number of AMN in the upper and lower limbs. Older children, adolescents with history of sunburns and with lighter skin had a higher number of total, small and large nevi. The average number of AMN found in this study is similar to that reported in the literature. The differences in site distribution between males and females may be explained by a different sun exposure pattern.
Full Text Available A 52-year-old White man presented with a dozen small, well-restricted, punctiform, asymptomatic, blue-gray macules on the left shoulder. A few months earlier, he had been treated with oral acyclovir for herpes zoster (HZ affecting the left C7–C8 dermatomes. All the blue macules appeared over a short period of time and then remained stable. The patient had not experienced any previous trauma or had tattooing in this anatomical region. The clinical diagnosis suggested blue nevi. Dermatoscopy revealed small, well-limited, dark-blue, compact, homogeneous areas evoking dermal blue nevi. An excisional biopsy was performed and the histological examination confirmed a blue nevus. As far as we are aware of, this is the first report of eruptive blue nevi following HZ, and it should be included in the differential diagnosis of zosteriform dermatoses responding to an isotopic pathway. In addition, a brief review concerning eruptive nevi is presented.
Strazzula, Lauren; Vedak, Priyanka; Hoang, Mai P; Sober, Arthur; Tsao, Hensin; Kroshinsky, Daniela
The management of dysplastic nevi (DN) is a highly debated and controversial topic within the dermatology community. Clinicians agree that margin-positive severely DN should be removed with a surgical margin, however, there is disagreement surrounding the appropriate management of margin-positive mildly and moderately DN. We sought to evaluate the utility of re-excising margin-positive mildly and moderately DN. A retrospective chart review was conducted on all adult patients given the diagnosis of a biopsy-proven DN from 2010 through 2011. The primary outcomes were defined as the presence of melanocytic residuum in re-excisional specimens and a clinically significant change in diagnosis. A total of 1809 mildly and moderately DN were diagnosed from 2010 through 2011. In all, 765 (42.3%) of these lesions were found to have positive surgical margins during biopsy, and 495 (64.7) of the 765 lesions were subsequently re-excised. Melanocytic residuum was present in 18.2% of re-excisional specimens. Re-excision resulted in a clinically significant alteration of the diagnosis in only 1 case (0.2%). Limitations include retrospective design and inability to assess for malignant transformation given limited follow-up. Re-excising mildly and moderately DN results in a low histopathological yield and rarely results in a clinically significant change in diagnosis. As such, clinical monitoring of margin-positive lesions may be warranted. Copyright © 2014 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Fernandes, Juliana Dumêt; Rivitti-Machado, Maria Cecilia; Nakano, Juliana; de Oliveira Rocha, Bruno; Oliveira, Zilda Najjar P
Epidermolysis bullosa (EB) nevi are acquired pigmented melanocytic lesions which may have clinical and dermoscopic features quite similar to those found in melanoma. More detailed information on this phenomenon is still lacking. To evaluate clinical, dermoscopic, and histopathological features of melanocytic lesions in 13 patients with dystrophic EB (DEB). Patients underwent clinical and dermoscopic evaluation. Suspicious lesions were excised and examined microscopically. There were 12 cases of recessive DEB and one of dominant DEB. Five patients were men; 8 were women; the ages ranged from 2 to 27 years old. All patients had at least 2 atypical melanocytic lesions. Two of the 5 biopsied patients showed an atypical nevus or lentigo on histopathological examination. We observed a high incidence of large and atypical melanocytic lesions in DEB patients. Although the exact explanation for this is still unclear, it seems that re-epithelization and the chronic inflammatory process may stimulate the proliferation of melanocytes, as well as the emergence of lesions with atypical clinical and dermoscopic features. As an unequivocal discrimination from malignant melanoma in vivo is not always possible, regular clinical follow-up and histopathological evaluation of suspicious lesions in EB patients are mandatory. © 2014 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.
Massey, Philip; Gronwall, Caryl; Pilachowski, Catherine A.
Absolute spectrophotometry of the Kitt Peak night sky at a variety of azimuths an zenith angles is presented, and the effect of population increase in Pima County on the dark-sky properties of Kitt Peak National Observatory in Arizona is studied. The results confirm that Kitt Peak remains a dark site, even after significant recent population growth of the surrounding area. The major line contributor to the B band is Hg, while the dominant source of contamination to the V-band measures are atmospheric lines, most notably O I 5577 A. Using fluxed observations of street lamps it was found that the relative contribution to light pollution in the yellow-red (5000 A - 6500 A) is 10 percent Hg, 30 percent LPS, and 60 percent HPS. No significant azimuthal effects are seen; it is noted that the sky remains equally dark toward Phoenix and Tucson as it does in other directions for zenith distances of 60 deg or less.
William M. Aird
Full Text Available The early career of Archbishop Anselm of Canterbury (c. 1033–1109 provides an opportunity to explore the operation of charismatic authority in a monastic setting. It is argued that the choice of Anselm for the archiepiscopal see of Canterbury in 1093 was the result of his growing reputation cultivated during his years as prior and abbot of the influential Norman monastery of Bec. The article explores various aspects of Anselm’s charismatic authority including his performance of charisma, the charisma derived from his fame as a scholar, and his reputation as a miracle-working holy man.
interactions (Lombard ., 2001; Torkpo .,. 2006). Thus, gel electrophoresis has become a ... capacity for two days prior to the time of sperm collection. Oocyte maturation and ovulation in the female broodstocks of the two ..... natural populations by means of a distance analysis. : 31:341-346. Buth, D. G. 1984. The Application of.
Full Text Available Background and Design: Compared to nevi in other regions, acral melanocytic nevi have special dermoscopic features due to their anatomical localizations. It may be difficult to distinguish the melanocytic nevi in these regions from early acral melanoma. For this reason, it is important to know the dermoscopic patterns of acral melanocytic nevi. Our aim was to evaluate the dermoscopic patterns and distribution features of acral melanocytic nevi.Material and Method: One hundred ninety-six acquired acral melanocytic nevi of 131 patients were evaluated retrospectively in this study. The demographic features such as age and sex, localization and pattern of nevi were recorded.Results: Of the 131 patients, 77 (58.7% were female and 54 (41.3% were male. Of all nevi, 92 (46.9% were present on the palms, 104 (53.1% were present on the soles. The localizations of acral nevi were as follows: inner arch (20%, finger (18.4%, hypothenar (12.8%, middle region (12.8%, thenar (11.7%, outer arch (10.2%, metatarsal region (8.7% and heel (5.6%. The most common dermoscopic pattern was parallel furrow pattern (40.8%. The other patterns seen were homogeneous (15.8%, latticelike (11.7%, fibrillar (9.7%, globular (9.7%, reticular (5.6%, nontypical (3.6%, the pattern suggestive of malignancy (2.0% and transition pattern (1%. Parallel furrow pattern, fibrillar and homogenous patterns were significantly more frequent on fingers, inner arch and outer arch, given in decreasing order (p<0.01, p<0.01, p=0.02, respectively. The four lesions suggestive of malignancy (2.0% were excised and diagnosed as compound nevus, dermal nevus, dysplastic nevus and malignant melanoma. Conclusion: The three most frequently observed patterns were parallel furrow, homogenous and latticelike patterns, in decreasing order. The nevi were most frequently located on the inner arch. Parallel furrow pattern was mostly located on the fingers, fibrillar pattern and homogenous pattern were mostly seen on
Navarro, Ryan; Nair, Rajeev; Peda, Andrea; Aung, Meiji Soe; Ashwinie, G S; Gallagher, Christa A; Malik, Yashpal S; Kobayashi, Nobumichi; Ghosh, Souvik
Although canine parvovirus (CPV) and canine enteric coronavirus (CCoV) are important enteric pathogens of dogs and have been studied extensively in different parts of the world, there are no reports on these viruses from the Caribbean region. During 2015-2016, a total of 104 diarrheic fecal samples were collected from puppies and adult dogs, with or without hemorrhagic gastroenteritis, on the Caribbean island of St. Kitts (KNA). By PCR, 25 (24%, n=104) samples tested positive for CPV. Based on analysis of the complete deduced VP2 amino acid sequences, 20 of the KNA CPV strains were assigned to new CPV-2a (also designated as CPV-2a-297A). On the other hand, the VP2 genes of the remaining 5 strains were partially characterized, or could not be sequenced. New CPV-2a was the predominant CPV variant in St. Kitts, contrasting the molecular epidemiology of CPV variants reported in most studies from nearby North and South American countries. By RT-PCR, CCoVs were detected in 5 samples (4.8%, n=104). Based on analysis of partial M-protein gene, the KNA CCoV strains were assigned to CCoV-I genotype, and were closely related to CCoV-I strains from Brazil. To our knowledge, this is the first report on detection and genetic diversity of CPV and CCoV in dogs from the Caribbean region, and underscores the importance of similar studies in the other Caribbean islands. Copyright © 2017 Elsevier B.V. All rights reserved.
As a religion based on the teaching of Jesus Christ, from the outset Christianity has developed a completely different attitude toward health and illness than the Old Testament. Health and illness are now viewed through the eyes of Jesus Christ the redeemer, who accepted each and every man. The history of Christianity has had its episodes of masochistic attitude toward illness, but today it clearly underscores the need to fight it with any means available, but it also teaches to accept what can not be changed. Saints are often patrons against diseases they had to endure. However, this is not their main role. To this day many seem to miss the main point their heritage, but see them as miracle healers. This misperception of miracle needs revising as well as the simplistic interpretation of the healing powers of relics (viewed as a demiurge of sort) and of the private vows and votive offerings.
Full Text Available Background and Design: Melanocytic nevi (MN count is known as the strongest risk factor for melanoma development. So it is important to know the MN count in public. We aimed to determine the MN prevalence in schoolchildren and also clarify the possible relation between MN counts, constitutional variables and sun exposure. Material and Method: In this randomized, cross-sectional study, a questionnaire asking skin phenotypes and sun exposure in previous summer was prepared for primary-school children. Nine hundred and sixty questionnaires distributed to the parents. Children who were given permission by parents for examination were examined for whole body MN. Results: Questionnaires were answered by parents of 939 children and 622 children (316 boys and 306 girls were examined. Mean age of children was 8.8±1.5 (6-12. Mean MN count was 19.6±16.6 and this count was increasing with age (p<0.001. MN count was significantly related with sex, skin phototype and skin colour. More MN were found in boys (p<0.001, children with sun sensitive phototypes (p=0.03 and light skin colour (p<0.001. Time spent outside on midday in previous summer was not related with the MN count (p=0.35. Sunburns experienced in previous summer were not related with MN count (p=0.11. MN were most densely located on the face, and then on upper extremity, trunk and lower extremity in decreasing order. There were more MN on the more sun exposed sites of the arms, hands and feet. Conclusion: It was found that previous summer sun exposure had no effect on MN count in schoolchildren. However, relation between MN count and skin phenotype and distribution of the MN on the body suggest that sun exposure could affect MN count and this effect could be seen in a long period of time.
Marcos Rogerio Rosa
This thesis focuses on the investigation of reef communities of the Saint Peter and Saint Paul´s Archipelago (SPSPA) across an euphotic/mesophotic depth gradient. Sampling was performed on shallow and mesophotic areas (0 to 90 m depth) using SCUBA and a Remotely Operated Vehicle (ROV). The present work is composed of four chapters: Chapter 1 deals with the quantitative assessment of reef fish communities, which were divided in three distinct communities associated with different depth strata....
Sujet: YOUTH UNEMPLOYMENT, YOUTH UNREST, TRAINING PROGRAMMES, INFORMATION TECHNOLOGY, YOUNG WORKERS. Région: North and Central America, South America, West Indies, Dominica, Grenada, Jamaica, Saint Kitts and Nevis, Saint Lucia, Trinidad and Tobago. Programme: Économies en ...
attention accordée à la production alimentaire locale par les pays de la région. Région(s): Guyana, West Indies, Saint Kitts and Nevis, Saint Lucia, Trinidad and Tobago. Financement total : CA$ 5,000,000.00. Agroforesterie et alimentation des ...
Russia Uganda Bosnia and Herzegovina Georgia Macau SAR China Rwanda Ukraine Botswana Germany Macedonia Saint Kitts and Nevis United Arab Emirates...Brazil Ghana Madagascar Saint Lucia United Kingdom Brunei Gre ece Malaysia Saudi Arabia United States Bulgaria Gre nada Maldives Senegal Uruguay Burkina
Til-Pérez, G; Tomás-Barberán, M; Magri-Ruiz, C
Otorhinolaryngology is one of the few medical specialities which has a patron saint, Saint Blase (born 317-AD). He was a Doctor and Bishop in Sebaste, Armenia, and he suffered martyrdom under the rule of the Roman Emperor Licinio (Iliria 250 AD - Tsalonica 325 AD). He was acknowledged as having the ability to protect people against throat infections, after curing a child who had choked on a fishbone. The feast of Saint Blase is on February 3rd, and it is celebrated all over the Western world. There are many other Saints related to our speciality, who protect people against ear, nose and throat disorders. We have reviewed the world literature on this subject.
Engeln, Kathleen; Peters, Kaitlin; Ho, Jonhan; Jedrych, Jaroslaw; Winger, Daniel; Ferris, Laura Korb; Patton, Timothy
Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited. We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise. A retrospective single institutional study was conducted with 451 adult patients (mean age 41.3 years) with SDN biopsied between November 1994 and November 2004, with clinical follow-up of at least 5 years. In 451 patients with SDN, re-excision was performed on 36.6%. Two melanomas were diagnosed in the re-excision specimens. Subsequent metastatic melanoma developed in 7 patients, all of whom had a history of melanoma. Margin comments influenced decision to re-excise. This was a retrospective study at a single institution. Re-excision of all SDN may not be necessary. Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Ferreira, Elthon G; Torres, Maria da Conceição M; da Silva, Alison B; Colares, Larissa L F; Pires, Karine; Lotufo, Tito M C; Silveira, Edilberto R; Pessoa, Otília D L; Costa-Lotufo, Leticia V; Jimenez, Paula C
Saint Peter and Saint Paul's Archipelago is a collection of 15 islets and rocks remotely located in the equatorial Atlantic Ocean. In this particular site, the present project intended to assess the biodiversity and biotechnological potential of bacteria from the actinomycete group. This study presents the first results of this assessment. From 21 sediment samples, 268 strains were isolated and codified as BRA followed by three numbers. Of those, 94 strains were grown in liquid media and submitted to chemical extractions with AcOEt (A), BuOH (B), and MeOH (M). A total of 224 extracts were screened for their cytotoxic activity and 41 were significantly active against HCT-116 cancer cells. The obtained IC50 values ranged from 0.04 to 31.55 μg/ml. The HR-LC/MS dereplication analysis of the active extracts showed the occurrence of several known anticancer compounds. Individual compounds, identified using HR-MS combined with analysis of the AntiMarin database, included saliniketals A and B, piericidins A and C and glucopiericidin A, staurosporine, N-methylstaurosporine, hydroxydimethyl-staurosporine and N-carbamoylstaurosporine, salinisporamycin A, and rifamycins S and B. BRA-199, identified as Streptomyces sp., was submitted to bioassay-guided fractionation, leading to isolation of the bioactive piericidins A and C, glucopiericidin, and three known diketopiperazines, cyclo(l-Phe-trans-4-OH-l-Pro), cyclo(l-Phe-l-Pro), and cyclo(l-Trp-l-Pro). © 2016 Wiley-VHCA AG, Zürich.
Full Text Available Christian hagiography reveals not only the facts of life of individual saints, but first of all, it is a description of theexperience of God loving mankind. From the beginning of Christianity, of great importance in building faith, hope andlove had had stories about those believers who responded with a particular radicalism for the prevenient love of God inthe Trinity of Persons. These stories have been written in various forms of literature.Author in the introductory part of the article introduces into the lives of the saints and their role in the Ruthenian andRussian Orthodoxy. Essentially he focuses on presenting The Menaia edited by St Dimitry Rostovski. This book waspublished in the years 1711 to 1718 in Old Church Slavonic. At the beginning of the twentieth century, it has been rewrittenand translated into Russian. This monumental work appeared in the years 1903-1911 under the title The Lives of theSaints. It has been a rich source of information for researchers from many disciplines.From a theological point of view, the author studied The Lives of the Saints in order to find direct references to theperson and teaching of Jesus Christ. For this purpose, he analyzed quotations from the New Testament, especially fromthe Gospel, referring directly to the Person and teaching of Jesus Christ, as well as the prayers addressed to Him. In hisanalysis, he searched for answers to the questions: Who is Jesus Christ for the Ruthenian and Russian saints, and whatkind of His images predominate in The Lives of the Saints.The first part of the article, on the basis of source texts, indicates personal qualities of Jesus Christ. The Savior hasbeen experienced by the Ruthenian and Russian saints as God who is close to man, the blessed King, the best Lord, theComforter of the crying, the Light, the merciful God, and the Foundation of all good. The image of Christ as sinless,innocent suffering and merciful shines especially in the devotion of Saints Passion
Full Text Available Comunicamos dos casos de nevo del tejido conectivo, el primero con patrón histológico mixto y el segundo con predominio de alteraciones en las fibras elásticas. No se constataron síndromes ni patología sistémica asociada. Un caso presentó disposición linear y un nevo acrómico asociado.Two cases of connective tissue nevi are reported, one of them with a mixed histopatologic pattern and one with elastin fibers diminished. None of the patients had systemic involvement or associated syndromes. The mixed connective tissue nevi type showed a linear distribution and has associated an acromic nevi.
Full Text Available Moscou et Saint-Pétersbourg ont connu une évolution chromatique similaire mais les différences en matière de plan, d’urbanisme et d’influences culturelles, et leurs rôles alternés de capitale ont déterminé leurs particularités chromatiques propres. Le Moscou en bois du xiiie siècle s’est enrichi d’un ensemble de cathédrales blanches aux coupoles dorées entourées par la muraille en brique rouge du Kremlin. Le style baroque a introduit dans l’architecture de Moscou et de Saint-Pétersbourg les couleurs bleu foncé, orange et verte. À l’époque du classicisme, on utilisait la palette officielle de teintes pastel à dominante ocre. L’achromatisme devient ensuite un trait distinctif de l’éclectisme en Russie. Au début du XXe siècle, l’Art nouveau ranime les villes grâce aux couleurs verte, orange et violette. Dans les années 1920 et 1930, les constructivistes utilisent les tons gris mais tentent d’élaborer un code chromatique homogène. L’architecture soviétique, quant à elle, reprend l’esthétique du classicisme « ocre ». La construction de masse des années 1960 aux années 1980 méconnaît la couleur, mais à la charnière des XXe et XXIe siècles apparaissent des approches professionnelles qui visent à créer un milieu chromatique similaire pour les deux villes.Moscow and Saint Petersburg experienced similar evolutions in colour, but the differences in their plans, urbanity and cultural influences, and their alternating roles as capitals, determined the particularities of their palettes. The wooden Moscow of the thirteenth century was enriched by a group of white cathedrals with golden domes, surrounded by the red brick wall of the Kremlin. Baroque, as an architectural style, introduced Moscow and Saint Petersburg to the colours dark blue, orange, and green. The official palette of classicism was pastel, predominantly ochre, while the period of eclecticism in Russia was achromatic. At the
Moustafa, Abdel-Raouf A. [عبد الرؤوف عبد الرحمن مصطفى; Kamel, Wafaa M.
The present study is aimed at (1) giving complete list of all plant speciec growing in Saint Catherine mountains, (2) studying the relationship between species number and the amount of precipitation at the time of study (1992 -1994), and (3) reporting on the geographical distribution of the ten most endangered and endemic species in the study area. Presence / absence tests were applied to forty-five stands distributed in Saint Catherine mountains. Distribution and ecological data (including a...
Schanke, Arne van; Venrooij, Gemma M C A L van; Jongsma, Marjan J; Banus, H Alexander; Mullenders, Leon H F; Kranen, Henk J van; Gruijl, Frank R de
Nevi and melanomas correlate to childhood and intermittent solar UV exposure, xeroderma pigmentosum patients run increased risk, and p16(Ink4a) expression is often lost in malignant progression. To ascertain the effect of these risk factors, pigmented hairless Ink4a/Arf-, Xpa- knockout mice were
Gheorghe Gh. BĂLAN
Full Text Available The history of medicine and dentistry shows that dental medicine is entitled to take upon itself, as representative elements of the field, symbols or spiritual protectors, religious (either Christian or pagan archetypes from different historical periods. These paved the way for the elaboration of a long-lasting set of professional and ethical criteria that ennoble today the dental profession. The present study analyzes some of the symbols of historical-religious nature, stressing their cultural impact and the manner in which such symbols are interpreted in various scientific, medical, theological, artistic contexts and, last but not least, in the general social perception. The professional ethical domain of dentistry makes use of numerous symbols with religious connotation, the more so that this branch of medicine and the various religions have numerous elements in common. Either stylistically, or appearing as products of folk culture, the main symbolistic or legendary references specific to dental culture are the legend of Cadmus and the canonization of Saint Apollonia, the champion of dentists and of those suffering from toothache. Such symbols give to the representatives of this profession a feeling of belonging to a noble medical domain; they also decode and facilitate communication with patients, therefore being outflanked by the idea that awareness on the existence of such religious symbols and on their practical cohesion is especially helpful.
Lihacova, I.; Bolocko, K.; Lihachev, A.
The incidence of skin cancer is still increasing mostly in in industrialized countries with light- skinned people. Late tumour detection is the main reason of the high mortality associated with skin cancer. The accessibility of early diagnostics of skin cancer in Latvia is limited by several factors, such as high cost of dermatology services, long queues on state funded oncologist examinations, as well as inaccessibility of oncologists in the countryside regions - this is an actual clinical problem. The new strategies and guidelines for skin cancer early detection and post-surgical follow-up intend to realize the full body examination (FBE) by primary care physicians (general practitioners, interns) in combination with classical dermoscopy. To implement this approach, a semi- automated method was established. Developed software analyses the combination of 3 optical density images at 540 nm, 650 nm, and 950 nm from pigmented skin malformations and classifies them into three groups- nevi, pigmented basal cell carcinoma or melanoma.
Cortés, Manuel E; Del Río, Juan Pablo; Vigil, Pilar
The objective of this editorial is to show that a harmonious relationship between science and faith is possible, as exemplified by great saints of the Catholic Church. It begins with the definitions of science and faith, followed by an explanation of the apparent conflict between them. A few saints that constitute an example that a fruitful relationship between these two seemingly opposed realities has been possible are Saint Albert the Great, Saint John of the Cross, Saint Giuseppe Moscati, and Saint Edith Stein, among others, and this editorial highlights their deep contributions to the dialogue between faith and reason. This editorial ends with a brief discussion on whether it is possible to be both a scientist and a man of faith.
Full Text Available Saint Sampson, whose feast is celebrated on June 27, was depicted among holy physicians. However, his images were not frequent. He was usually accompanied with Saint Mokios (in Saint Sophia in Kiev, the Transfiguration church in the Mirozh monastery and the church of the Presentation of the Holy Virgin in the Temple in the monastery of Saint Euphrosyne; possibly also in Saint Panteleimon in Nerezi and Saint Demetrios in the village of Aiani near Kozani; furthermore, in the church of Saint Nicholas in Manastir and, afterwards, in the katholikon of the Vatopedi monastery. In a later period, he was usually shown in the vicinity of Saint Diomedes (in the churches of Saint Achillius in Arilje, Saint George in the village Vathiako on Crete, Saint Nicholas Orphanos in Thessaloniki, the Annunciation in Gračanica, the narthexes of the Hilandar katholikon and the church of the Holy Virgin in the monastery of Brontocheion at Mistra, the katholicon of the Pantokrator monastery and the church of Saint Demetrios in Markov Manastir. There are no substantial data regarding the identity of the saints depicted next to him in the metropolitan Church of Saint Demetrios at Mistra, while in a number of cases the image of the saint shown next to him has not been preserved (e.g. Saint Irene in the village of Agios Mamas on Crete, Gregory’s Gallery in the church of Saint Sophia in Ohrid and the church of the Holy Virgin (Panagia Kera near the village Chromonastiri on Crete. On the other hand, in the church of the Holy Virgin in Mateič, Saint Sampson is, exceptionally, depicted among bishops, while in the church of the Holy Archangels in Prilep and the chapel of the Holy Anargyroi in Vatopedi, he is, as usual, surrounded by holy physicians but his mates are not featured - neither Saint Mokios, not Saint Diomedes. The earliest known commemorative text dedicated to him is the extensive hagiography - Vita Sampsonis I, composed in the seventh or the early eighth century
Johansen, Peter; Andersen, Jeppe Dyrberg; Madsen, Linnea Nørgård
pigmentation measured on the buttock area. We hypothesize that the effect of MC1R variants on arm pigmentation is primarily reflecting the inability to tan when subjected to UVR. A gender specific effect on skin pigmentation was also observed, and it was found that the skin pigmentation of females on average......To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis) contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical...... variants (missense, NM_002386:c. 456C > A (p.TYR152*), or NM_002386:c.83_84insA (p.Asn29Glnfs*14) had significantly (ppigmentation of the upper-inner arm than those with none or one MC1R variant. We did not observe any significant association of the MC1R variants with constitutive...
Danielle de Lima Viana
Full Text Available Feeding aspects of the oilfish, Ruvettus pretiosus, were studied based on 360 stomachs of both male and female specimens caught off the Saint Peter and Saint Paul Archipelago. The total length of the specimens ranged from 52.4 cm to 189.0 cm. Of the 360 stomachs examined, 135 presented some food and 225 were empty. Thirty-four taxa were identified, represented by 16 fish, 17 cephalopods and 1 crustacean. The stabilization of the food items richness was attained at 35 food items and 104 stomachs, approximately. A remarkable predation upon the flying fish Cheilopogon cyanopterus was observed around SPSPA, directly related to the main reproductive period of this species in the area. The oilfish's food spectrum shows that the species feeds on a wide vertical range in the water column, catching prey items at the surface or in shallow waters, as well as epi-mesopelagic fish, in addition to mesopelagic cephalopods.Aspectos alimentares do peixe-prego, Ruvettus pretiosus, foram estudados com base nos estômagos de 360 espécimes, de ambos os sexos, capturados nos arredores do Arquipélago de São Pedro e São Paulo. Todos os exemplares foram capturados com linha de mão. O comprimento total dos exemplares variou de 52,4 cm a 189,0 cm. Dos 360 estômagos examinados, 135 apresentaram algum alimento e 225 estavam vazios. Trinta e quatro táxons foram identificados, representados por 16 peixes, 17 cefalópodes e um crustáceo. A estabilização da riqueza dos itens alimentares foi obtida com 35 itens e 104 estômagos. Uma predação notável sobre o peixe-voador Cheilopogon cyanopterus foi observada nas adjacências do ASPSP, diretamente relacionada com o principal período reprodutivo dessa espécie na área. O espectro alimentar do peixe-prego mostra que a espécie se alimenta em uma ampla faixa vertical na coluna d'agua, capturando desde presas de superfície ou águas rasas, a peixes epi-mesopelágicos, além de cefalópodes mesopelágicos.
Sindik Dušan I.
Full Text Available The location called Trinity is situated nearby Kotor (Cattaro, and was most probably named after the Saint Trinity Church, built at the same place. The church does not exist any more. Several documents regarding that church have been kept. One of them, written in September 1476, is subject of analysis of this contribution. As it happened, instead of a priest died in May of the same year, the church was taken care by the Minor Council upon the suggestion of the city of Kotor. The election of the same priest was performed in the Minor Council, upon suggestion of the two electors, by secret voting of all members of the Council. It seems the document to be the only one from the Archive of Kotor (today kept in the State Archive of Zadar, in which has been described the voting in the Minor Council, with presences of the two members of Council, who had voted with the golden balls (balotta aurea electionis. As it is possible to see from this case, as well as from the other documents kept in the city archives along the eastern Adriatic Coast, their role was to suggest personalities for important city duties. It is also possible to see from the document that the Minor Council of the Kotor Municipality had separated a book in which the records for the sessions or at least decisions of the Council was registered. The second interesting thing in this document is the name of the deceased priest. His name was don Matej Ćurilica, which should be understood as a nickname, given because of that he had probably served upon the Roman ritual, but in Slavic language, from the books written in Cyrillic or Glagolitic alphabet. The first name for the Glagolitic alphabet was kjurilica. There are strong reasons for presumptions that still in the first half of the 12th century the Glagolitic alphabet was in use in the regions southeast from Dubrovnik.
The aim of this paper is to show the interpolation in the Epiclesis of Anaphora prayers in the Liturgies of St. John Chrysostom and St. Basil the Great. The analysis will cover the changes made in the second millennium, in particular the emergence of the troparion of the third hour service, and interpolation of the words “changing it by your Holy Spirit”. The text shows the genesis of adding additional words and explains what their effect was on the structure of the Anaphora prayers. As a res...
Full Text Available The aim of this paper is to show the interpolation in the Epiclesis of Anaphora prayers in the Liturgies of St. John Chrysostom and St. Basil the Great. The analysis will cover the changes made in the second millennium, in particular the emergence of the troparion of the third hour service, and interpolation of the words “changing it by your Holy Spirit”. The text shows the genesis of adding additional words and explains what their effect was on the structure of the Anaphora prayers. As a result, proposals to solve the problems arising from historical changes in the structure of the Epiclesis and in the whole prayer of the Anaphora will be presented.
Saab, Jad; Santos-Zabala, Maria Laureana; Loda, Massimo; Stack, Edward C; Hollmann, Travis J
Melanoma is a potentially lethal form of skin cancer for which the current standard therapy is complete surgical removal of the primary tumor followed by sentinel lymph node biopsy when indicated. Histologic identification of metastatic melanoma in a sentinel node has significant prognostic and therapeutic implications, routinely guiding further surgical management with regional lymphadenectomy. While melanocytes in a lymph node can be identified by routine histopathologic and immunohistochemical examination, the distinction between nodal nevus cells and melanoma can be morphologically problematic. Previous studies have shown that malignant melanoma can over-express metabolic genes such as fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC). This immunohistochemical study aims to compare the utility of FASN and ACC in differentiating sentinel lymph nodes with metastatic melanomas from those with benign nodal nevi in patients with cutaneous melanoma. Using antibodies against FASN and ACC, 13 sentinel lymph nodes from 13 patients with metastatic melanoma and 14 lymph nodes harboring benign intracapsular nevi from 14 patients with cutaneous malignant melanoma were examined. A diagnosis of nodal melanoma was based on cytologic atypia and histologic comparison with the primary melanoma. All nodal nevi were intracapsular and not trabecular. Immunohistochemistry for Melan-A, S100, human melanoma black 45 (HMB45), FASN, and ACC were performed. The percentage of melanocytes staining with HMB45, FASN, and ACC was determined and graded in 25% increments; staining intensity was graded as weak, moderate, or strong. All metastatic melanomas tested had at least 25% tumor cell staining for both FASN and ACC. Greater than 75% of the tumor cells stained with FAS in 7/13 cases and for ACC in 5/12 cases. Intensity of staining was variable; strong staining for FASN and ACC was observed in 69% and 50% of metastatic melanoma, respectively. HMB45 was negative in 40% of nodal
Cebulla, Colleen M; Alegret, Armando M; Feuer, William J; Shi, Wei; Schefler, Amy C; Murray, Timothy G
To study the reduction in tumor size and the safety and efficacy of combined phacoemulsification and intravitreal triamcinolone acetonide injection (phaco-IVTA) in patients with treated melanoma and atypical nevi. Bascom Palmer Eye Institute, Miami, Florida, USA. The medical records of 49 consecutive patients (51 eyes) with treated melanoma or atypical nevi treated with phaco-IVTA were evaluated retrospectively for changes in Snellen visual acuity, tumor volume, and frequency of complications. Main outcome measures included a postsurgical change in tumor size greater than or equal to 0.5 mm of height or 1.0 mm of basal diameter by echographic analysis, improvement in visual acuity at 6 months and final follow-up, and complications including endophthalmitis, cystoid macular edema, epiretinal membrane, increased intraocular pressure, and persistent corneal edema. The median baseline visual acuity was 20/80 in the affected eye. At the 6-month follow-up examination, 13 (68%) of 19 eyes had achieved better than 20/40 visual acuity. Treated uveal melanomas (n=30) and atypical choroidal nevi (n=21) were stable with combined therapy, and echographic measurements improved in 12 eyes. Intraocular pressure increased from baseline to 25 mm Hg or more postoperatively in 4 of 51 eyes (8%). No other significant complications occurred. Combined phacoemulsification and IVTA was reasonably safe in patients with treated melanoma and atypical nevi. Tumors remained stable or decreased slightly in size. Intravitreal triamcinolone acetonide injection at the time of cataract surgery in patients with treated melanoma or nevus may reduce rates of tumor progression in these patients.
Pigmentary traits, modalities of sun reaction, history of sunburns, and melanocytic nevi as risk factors for cutaneous malignant melanoma in the Italian population: results of a collaborative case-control study.
Naldi, L; Lorenzo Imberti, G; Parazzini, F; Gallus, S; La Vecchia, C
To the authors' knowledge, limited data are available from Mediterranean populations concerning risk factors for malignant melanoma. A few Italian case-control studies have produced conflicting results regarding the association between malignant melanoma and pigmentary traits, sunburns, and melanocytic nevi. A case-control study was conducted within the framework of the Italian Group for Epidemiologic Research in Dermatology (GISED). Twenty-seven centers in the north and south of Italy participated. A total of 542 cases and 538 controls were entered onto the study. A standardized questionnaire was administered to cases and controls. Cases and controls also were examined by trained dermatologists who were required to count the number of melanocytic nevi (those measuring > or = 2 mm and > 6 mm in greatest dimension, separately) and to make judgments regarding pigmentary traits. In the multivariate analysis, eye and skin color, propensity to sunburn, history of sunburns before age 15 years, and solar lentigines all were associated with malignant melanoma. In addition, the risk of melanoma increased with the number of melanocytic nevi > or = 2 mm. Nevi > 6 mm in greatest dimension had effects on risk that appeared to be independent from the effects of smaller nevi (2-6 mm). The results of the current study largely are similar to those obtained in northern European countries, the U.S., and Australia and provide further evidence of the importance of selected pigmentary traits, sun exposure, and the number of melanocytic nevi in the risk of cutaneous malignant melanoma. Copyright 2000 American Cancer Society.
Camus, E; Martinez, D; Beauperthuy, L; Benderdouche, A; Coisne, S; Corbette, C; Denormandie, N; Garris, G; Harris, E; King, T
A sero-epidemiological survey for heartwater was organized in 1992 in the Lesser Antilles, from Grenada to Saint Martin. Blood from about one percent of the ruminant livestock of the islands was randomly sampled and the sera were tested with an indirect ELISA. The percentage of positive sera was found to be 30% in Guadeloupe, 25% in Antigua, 2.2% in St.Martin, 1.3% in St. Kitts & Nevis, 3.8% in Montserrat, 1.7% in Dominica, 1.5% in St.Lucia, 1.5% in St.Vincent, 3.5% in Barbados, 2.9% in Grenada and 7% in Martinique. Ruminants from Guadeloupe and Antigua are known to be infected with heartwater. The low percentage of positive sera and the absence of clinical cases in the other islands strongly suggest that positive sera in these islands are probably due to non-specific cross reactions between Cowdria and other micro-organisms (possibly Ehrlichia) which remain to be isolated. In particular, the high percentages of positive sheep sera in Martinique (15%) and Montserrat (11%) should be further investigated.
KENJI F. MOTOKI
Full Text Available This paper presents gravimetric and morphologic analyses based on the satellite-derived data set of EGM2008 and TOPEX for the area of the oceanic mantle massif of the Saint Peter and Saint Paul peridotite ridge, Equatorial Atlantic Ocean. The free-air anomaly indicates that the present plate boundary is not situated along the longitudinal graben which cuts peridotite ridge, but about 20 km to the north of it. The high Bouguer anomaly of the peridotite ridge suggests that it is constituted mainly by unserpentinised ultramafic rocks. The absence of isostatic compensation and low-degree serpentinisation of the ultramafic rocks indicate that the peridotite ridge is sustained mainly by active tectonic uplift. The unparallel relation between the transform fault and the relative plate motion generates near north-south compression and the consequent tectonic uplift. In this sense, the peridotite massif is a pressure ridge due to the strike-slip displacement of the Saint Paul Transform Fault.
Madsen, Susan R.
The article examines theories, assumptions, concepts, experiences, and practices from the Latter-day Saints' (LDS, or the Mormons) religious worldview to expand existing theoretical constructs and implications of leadership development and education for women. The article elucidates LDS doctrine and culture regarding women and provides specific…
Sand, Michael; Skrygan, Marina; Georgas, Dimitrios; Sand, Daniel; Gambichler, Thilo; Altmeyer, Peter; Bechara, Falk G
Although several studies have shown a dysregulation of microRNA (miRNA) expression profiles in cutaneous melanoma, there has been little research on the miRNA machinery itself. In this study, we investigated the mRNA expression profiles of different miRNA machinery components in primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM) and benign melanocytic nevi (BMN). Patients with PCMM (n = 7), CMMM (n = 6) and BMN (n = 7) were included in the study. Punch biopsies were harvested from the centers of tumors (lesional) and from BMN (control). In contrast to previous reports exploring specific clusters of miRNAs in PCMM, the present study investigates mRNA expression levels of Dicer, Drosha, Exp5, DGCR8 and the RISC components PACT, argonaute-1, argonaute-2, TARBP1, TARBP2, MTDH and SND1, which were detected by TaqMan real-time reverse transcription polymerase chain reaction (RT-PCR). Argonaute-1, TARBP2 and SND1 expression levels were significantly higher in BMN compared to PCMM (p 0.05). The results of this study show that the miRNA machinery components argonaute-1, TARBP2 and SND1 are dysregulated in PCMM and CMMM compared to BMN and may play a role in the process of malignant transformation.
Goldstein, A.M.; Fraser, M.C.; Tucker, M.A.; Dracopoli, N.C.; Engelstein, M. (Massachusetts Institute of Technology, Cambridge, MA (United States)); Clark, W.H. Jr. (Univ. of Pennyslvania School of Medicine, Philadelphia, PA (United States))
The authors examined the relationship between cutaneous malignant melanoma/dysplastic nevi (CMM/DN) and chromosome 9p in 13 pedigrees with two or more living cases of invasive melanoma. They used two highly informative (CA)[sub n] repeats, D9S126 and IFNA, previously implicated in familial malignant melanoma (MLM), to conduct linkage analysis. Three analyses were performed: (1) CMM alone - all individuals without either confirmed melanoma or borderline lesions were considered unaffected (model A); (2) CMM/DN with both variable age at onset and sporadics (model B); and (3) CMM affecteds only - all individuals either without confirmed melanoma or with borderline lesions were designated unknown' (model C). There was significant evidence for linkage to IFNA in all three models. For CMM along, the maximum lod score (Z[sub max]) was 4.36 at 0 = .10 for model A and 3.39 at 0 = .10 for model C. For CMM/DN (model B), Z[sub max] = 3.05 at 0 = .20. There was no significant evidence for heterogeneity when a homogeneity test allowing for linkage to chromosome 9p or chromosome 1p or neither region was used. These results suggest that there is an MLM susceptibility locus on chromosome 9p but that familial melanoma is heterogeneous and not all families with CMM/DN are linked to a locus in this region. 30 refs., 1 fig., 5 tabs.
Martin, Jennifer; Beese, Jane A.
This case was developed for use in a learning-centered course with a focus on administrative leadership and ethical behavior. This case describes the experience of a new faculty member at Saint Ambrose University, as she discovers a wide range of ethical and management problems in her department. The case unfolds as we track her efforts to deal…
Abstract This article is focused on the issues of cult of saints and shrines in the Samarqand province of Uzbekistan. The contribution of the author to the study of shrines of the region consists of that beside the summary of the existing material on pre-Soviet and Soviet periods, he used his own data. For this, the field material ...
Dmitriy Evgenyevich Afinogenov
Full Text Available The Slavonic translation of the Life of Saint Euthymius the Great (BHG 647 by Cyril of Scythopolis, attested at the earliest manuscript of the late 14th c., was probably made by a person originating from South-East Rus in the 11th c., as it displays some grammatical, lexical, and phonetic features peculiar for this area and time, and visible, in particular, in Ipatiev Chronicle and the Tale of Igor’s Campaign. It may have formed a part of the collection comprising several writings by Cyril, including the Life of Saint Sabas and the Praise of Euthymius and Sabas (lost in the Greek original. This collection was later incorporated into the Great Lectionary Menologion of Metropolitan Makarij. The details added by the translator to the description of certain realia pertaining to the Monastery of Saint Euthymius in Palestine suggest a personal knowledge of that monastic complex (the Laura and the coenobium. The proposed author of the translation is Saint Anthony of the Cave Monastery in Kiev († 1073, who could perfectly well have visited the Holy Land during his stay on Mount Athos prior to 1051.
Davis, Dennis R.
A study explored the role of work experience in addressing problems of homeless people in Saint Paul (Minnesota) during the 1989-91 grant cycles of the McKinney Job Training for the Homeless Demonstration Program. The program included a number of elements: outreach, intake, assessment and enrollment, orientation, work experience, basic…
The article deals with the role the physicians played in organization and functioning of the Community of Saint Eugene in St. Petersburg in 1882-1918. The typography production of the Community being of interest for history of medicine is examined.
Speeckaert, Reinhart; van Geel, Nanja; Luiten, Rosalie M.; van Gele, Mireille; Speeckaert, Marijn; Lambert, Jo; Vermaelen, Karim; Tjin, Esther P. M.; Brochez, Lieve
Regressing nevi are considered an example of an efficient early antitumoral response preventing the development of neoplasia. The underlying mechanism has not been elucidated, although an immune-based destruction of melanocytes is supposed. The aim of this study was to provide evidence of an
Giorgini, Elisabetta; Tosi, Giorgio; Conti, Carla; Staibano, Stefania; Ilardi, Gennaro; Sabbatini, Simona
In the last 10 years, few efforts have been carried out to apply vibrational spectroscopy in the study of dermal pathologies in order to characterize the most relevant spectral markers for distinguishing benign from cancerous lesions. Spitz nevi are a special group of benign melanocytic lesions, characterized by spindled and/or epithelioid nevomelanocytes, with peculiar clinical, dermoscopic and histopathological features. The "atypical forms" of Spitz nevi are among the commonest problems of differential diagnosis with the so-called "spitzoid melanomas". The clinical and histological criteria for discriminating these two entities are very subtle and often still quite subjective, and, in a significant percentage of cases, can lead to diagnostic pitfalls and inadequate therapies. Therefore, it is noteworthy to outline that the diagnosis of melanocytic lesions still represents a challenging problem and a continue matter of discussion. We exploited FTIR microspectroscopy to study the different kinds of spitzoid melanocytes, in order to define the most relevant spectral markers of each specimen and to achieve objective information on "borderline" histologically atypical lesions. In particular, the spectroscopic investigation was carried out on melanocytes deriving from normal skin (as a normal control), malignant melanoma and Spitz nevi. The presence of the characteristic bands of melanin was investigated, too.
Levy, Rebecca; Lara-Corrales, Irene
Common moles on the skin, known scientifically as melanocytic nevi, are seen frequently in the pediatric population. They are broadly grouped into two groups: congenital (generally present at birth or in infancy) or acquired. Congenital melanocytic nevi (CMN) are classified based on size and morphologic features. Neurocutaneous melanosis and melanoma represent two important complications, with overall risk affected by nevus size, location, appearance, and number of satellite lesions. Regular lifelong skin surveillance is required for high-risk CMN. Acquired melanocytic nevi (AMN) tend to appear in childhood and increase in number through adolescence. Risk factors for melanoma in children with moles include having more than 50 AMN, clinically atypical AMN, family history of melanoma, excessive ultraviolet light exposure, lightly pigmented skin, and immunosuppression. Children with risk factors should be monitored regularly. The periodic health examination presents an opportunity to perform total body skin examination to screen for concerning lesions and to provide anticipatory guidance about sun protection. [Pediatr Ann. 2016;45(8):e293-e298.]. Copyright 2016, SLACK Incorporated.
In June 1976 the St. Kitts' Family Planning Association began the 1st of 2 community contraception distribution projects with distribution of all types of contraceptives (orals, injectables, foams, jellies, and condom) throught 7 private practitioners. By August, 15 retail stores in villages began selling condoms and foaming tablets at subsidized prices. Family planning posters are displayed. Shopkeepers at 1st were afraid of negative reaction from customers but the advertising compaign during Family Planning Week (August 22-28) encouraged the vendors and their acceptance increased. The program is showing signs of success, especially in distribution centers far from clinics.
of the Greek fire-walking rituals. As a cognitive ethnography, the book aims to identify the social, psychological and neurobiological factors which may be involved and to explore the role of emotional and physiological arousal in the performance of such ritual. A study of participation, experience and meaning......The Anastenaria are Orthodox Christians in Northern Greece who observe a unique annual ritual cycle focused on two festivals, dedicated to Saint Constantine and Saint Helen. The festivals involve processions, music, dancing, animal sacrifices, and culminate in an electrifying fire-walking ritual...
Hunt, Raegan D; Orlow, Seth J; Schaffer, Julie V
Little is known about the prevalence and clinical characteristics of genital melanocytic nevi in children. We sought to describe the epidemiology, clinical and dermoscopic features, and natural history of genital nevi in pediatric patients. We reviewed charts of 1159 children given the diagnosis of melanocytic nevi over 11 years. Those with genital nevus as a chief symptom were contacted for follow-up. Among children/adolescents evaluated for nevi, the prevalence of genital nevus was 3.5% (40/1159), with a male:female ratio of 1.3:1. There were no statistically significant differences in age, sex, total nevus number, presence of acral and scalp nevi, or family history of dysplastic nevi and melanoma between patients with and without genital nevi. Genital nevus onset was before age 2 years in 63.6% of patients. A globular dermoscopic pattern was observed in 93.3%. Most genital nevi underwent a gradual change in diameter, elevation (becoming soft papules), color, texture, or a combination of these. After median follow-up of 1.5 years, no melanoma or other adverse outcome was observed. This was a retrospective chart analysis and questionnaire-based study of a limited number of patients. Increased awareness of the clinical characteristics, dermoscopic features, and evolution of genital nevi in children may help to avoid unnecessary surgery. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Madagascar. Malawi. Mali. ℓ. Mauritania. Mauritius. Morocco. Mozambique. Nepal†. Niger†. Nigeria. Peru†. Rwanda†. Saint Lucia. Sao Tome and Principe. Senegal. Seychelles. Sierra Leone. Somalia. ℓ. South Africa. South Sudan†. Sri Lanka. St. Kitts and Nevis. Sudan. Swaziland. Tanzania. Togo. Trinidad and Tobago.
Minott, Mark A.; Willett, Ionie Liburd
The purpose of this research was to identify and outline the work-related skills that cooperating teachers in the Cayman Islands and Saint Kitts-Nevis developed or reinforced as they supervised student-teachers. A qualitative case-study methodology was used. The findings indicate that cooperating teachers developed and reinforced essential…
Nicaragua Vietnam Netherlands Réunion Panama Norway Rwanda Parguay Poland Senegal Peru Portugal Seychelles St. Kitts and Nevis Romania Sierra Leone St...September 1979. Ray earned a Bachelor’s Degree in political science from Saint Joseph’s University and an MBA from LaSalle University, both of
L’agriculture à Saint-Georges de l’Oyapock : Bilan et perspectives Agricultura em Saint-Georges de l’Oyapock : Resultados e Perspectivas Agriculture in Saint-Georges de l’Oyapock: Results and Prospects
agricultural fact in Saint-Georges. Behind the somewhat fixed photography of the current agricultural occupation of the ground, we tried particularly to follow the route which goes from the choice of the piece of land and its development, at the destination of its products, by attaching us to the description of the access to the ground. Thought as of its origin like a tool of decision-making aid, this work highlighted the inconsistencies and the traps of the access to the ground, elements which could be integrated in the definition of a program of management to this agricultural area.
Full Text Available BACKGROUND: Distinguishing melanoma from dysplastic nevi can be challenging. OBJECTIVE: To assess which putative molecular biomarkers can be optimally combined to aid in the clinical diagnosis of melanoma from dysplastic nevi. METHODS: Immunohistochemical expressions of 12 promising biomarkers (pAkt, Bim, BRG1, BRMS1, CTHRC1, Cul1, ING4, MCL1, NQO1, SKP2, SNF5 and SOX4 were studied in 122 melanomas and 33 dysplastic nevi on tissue microarrays. The expression difference between melanoma and dysplastic nevi was performed by univariate and multiple logistic regression analysis, diagnostic accuracy of single marker and optimal combinations were performed by receiver operating characteristic (ROC curve and artificial neural network (ANN analysis. Classification and regression tree (CART was used to examine markers simultaneous optimizing the accuracy of melanoma. Ten-fold cross-validation was analyzed for estimating generalization error for classification. RESULTS: Four (Bim, BRG1, Cul1 and ING4 of 12 markers were significantly differentially expressed in melanoma compared with dysplastic nevi by both univariate and multiple logistic regression analysis (p < 0.01. These four combined markers achieved 94.3% sensitivity, 81.8% specificity and attained 84.3% area under the ROC curve (AUC and the ANN classified accuracy with training of 83.2% and testing of 81.2% for distinguishing melanoma from dysplastic nevi. The classification trees identified ING4, Cul1 and BRG1 were the most important classification parameters in ranking top-performing biomarkers with cross-validation error of 0.03. CONCLUSIONS: The multiple biomarkers ING4, Cul1, BRG1 and Bim described here can aid in the discrimination of melanoma from dysplastic nevi and provide a new insight to help clinicians recognize melanoma.
The first experiment at the Nevis Cyclotron by Bernardini, Booth and Lindenbaum demonstrated that nuclear stars are produced by a nucleon-nucleon cascade within the nucleon. This solved a long standing problem in Cosmic rays and made it clear that where they overlap cosmic ray investigation would not be competitive with accelerator investigations. The initial experiments at the Brookhaven Cosmotron by Lindenbaum and Yuan demonstrated that low energy pion nucleon scattering and pion production were unexpectedly mostly due to excitation of the isotopic spin = angular momentum = 3/2 isobaric state of the nucleon. This contradicted the Fermi statistical theory and led to the Isobar model proposed by the author and a collaborator. The initial experiments at the AGS by the author and collaborators demonstrated that the Pomeronchuck Theorem would not come true till at least several hundred GeV. These scattering experiments led to the development of the ''On-line Computer Technique'' by the author and collaborators which is now the almost universal technique in high energy physics. The first accomplishment which flowed from this technique led to contradiction of the Regge pole theory as a dynamical asymptotic theory, by the author and collaborators. The first critical experimental proof of the forward dispersion relation in strong interactions was accomplished by the author and collaborators. They were then used as a crystal ball to predict that ''Asymptopia''---the theoretically promised land where all asymptotic theorems come true---would not be reached till at least 25,000 BeV and probably not before 1,000,000 BeV. 26 refs., 11 figs., 2 tabs.
ROGERS, Tova; MARINO, Maria L.; RACITI, Patricia; JAIN, Manu; BUSAM, Klaus J.; MARCHETTI, Michael A.; MARGHOOB, Ashfaq A.
Melanocytic nevi (MN) encompass a range of benign tumors with varying microscopic and macroscopic features. Their development is a multifactorial process under genetic and environmental influences. The clinical importance of MN lies in distinguishing them from melanoma and in recognizing their associations with melanoma risk and cancer syndromes. Historically, the distinction between the different types of MN, as well as between MN and melanoma, was based on clinical history, gross morphology, and histopathological features. While histopathology with clinical correlation remains the gold standard for differentiating and diagnosing melanocytic lesions, in some cases, this may not be possible. The use of dermoscopy has allowed for the assessment of subsurface skin structures and has contributed to the clinical evaluation and classification of MN. Genetic profiling, while still in its early stages, has the greatest potential to refine the classification of MN by clarifying their developmental processes, biological behaviors, and relationships to melanoma. Here we review the most salient clinical, dermoscopic, histopathological, and genetic features of different MN subgroups. PMID:27119653
A. V. Santimov
Full Text Available Kawasaki disease (KD is acute systemic vasculitis of unknown etiology. Approximately 20–25% of untreated patients develop coronary artery changes with a range of severity from asymptomatic coronary artery dilatation to giant coronary artery aneurysms with thrombosis, myocardial infarction, and sudden death. To date there is no official data on the incidence of KD in Russia. In Russia, the disease is not enough known now to a wide circle of physicians and often masks other more common diseases. Since 2010, the detection rate of KD has dramatically increased in Saint-Petersburg.Objective: to analyze the experience in diagnosing and treating KD in two largest hospitals of Saint Petersburg.Patients and methods. The retrospective study included data on 30 children (18 boys, 12 girls who were hospitalized with a diagnosis of KD in the Saint-Petersburg State Pediatric Medical University Clinic and Children’s Hospital One (Saint Petersburg between January 2011 and September 2016. Data are represented by median and extreme values. The age of the children was 2.8 (0.2; 4.6 years; of them 5 (16.7% patients were under the age of 1 year. The children were hospitalized on 5 (1; 14 days of disease onset; KD was diagnosed on 9 (3; 52 day of the disease.Results. Immediately after diagnosis, 27 (90% children received aspirin. In early stages (before 10 days of the disease, intravenous immunoglobulin (IVIG therapy was performed in 15 (50% children, one of them received IVIG before disease day 5 (on day 3, but without effect. On disease days 11-20 (immediately after diagnosis, 10 (33.3% children were prescribed with IVIG; thereafter fever was abolished in all the patients. Their body temperature became normal on day 11 (6; 23. Ultrasonography revealed coronary artery lesions in 13 (43.3% patients. Out of the 30 children followed up, one baby who fell ill at the age of 3 months and received IVIG died on day 30 of the disease.Conclusion. Currently
Full Text Available To investigate whether pigmentation genes involved in the melanogenic pathway (melanogenesis contributed to melanoma predisposition, we compared pigmentary genetics with quantitative skin pigmentation measurements, the number of atypical nevi, the total nevus count, and the familial atypical multiple mole and melanoma (FAMMM syndrome. We typed 32 pigmentary SNP markers and sequenced MC1R in 246 healthy individuals and 116 individuals attending periodic control for malignant melanoma development, 50 of which were diagnosed with FAMMM. It was observed that individuals with any two grouped MC1R variants (missense, NM_002386:c. 456C > A (p.TYR152*, or NM_002386:c.83_84insA (p.Asn29Glnfs*14 had significantly (p<0.001 lighter skin pigmentation of the upper-inner arm than those with none or one MC1R variant. We did not observe any significant association of the MC1R variants with constitutive pigmentation measured on the buttock area. We hypothesize that the effect of MC1R variants on arm pigmentation is primarily reflecting the inability to tan when subjected to UVR. A gender specific effect on skin pigmentation was also observed, and it was found that the skin pigmentation of females on average were darker than that of males (p<0.01. We conclude that MC1R variants are associated with quantitative skin colour in a lightly pigmented Danish population. We did not observe any association between any pigmentary marker and the FAMMM syndrome. We suggest that the genetics of FAMMM is not related to the genetics of the pigmentary pathway.
Andall-Brereton, Glennis; Brown, Eulynis; Slater, Sherian; Holder, Yvette; Luciani, Silvana; Lewis, Merle; Irons, Beryl
To characterize high-risk human papillomavirus (HPV) infections in a sample of women in two small English-speaking Caribbean countries: Saint Kitts and Nevis and Saint Vincent and the Grenadines. Sexually active women ≥ 30 years old attending primary care health facilities participated in the study. Each participant had a gynecological examination, and two cervical specimens were collected: (1) a specimen for a Papanicolaou (Pap) test and (2) a sample of exfoliated cervical cells for HPV DNA testing, using the HPV High Risk Screen Real-TM (Sacace). High-risk HPV genotypes were assessed in 404 women in Saint Kitts and Nevis and 368 women in Saint Vincent and the Grenadines. High-risk HPV was detected in 102 of 404 (25.2%) in Saint Kitts and Nevis and in 109 of 368 (29.6%) in Saint Vincent and the Grenadines. High-risk HPV genotypes 52, 35, 51, 45, and 31 were the most common high-risk types in Saint Kitts and Nevis. In Saint Vincent and the Grenadines, the most common high-risk HPV genotypes were 45, 35, 31, 18, and 51. Current age was found to be significantly associated with high-risk HPV infection in both countries. In addition, in Saint Vincent and the Grenadines, high parity (> 3 pregnancies) and having had an abnormal Pap smear were found to be independent risk factors for high-risk HPV. These results contribute to the evidence on HPV prevalence for small island states of the Caribbean and support the accelerated introduction of the 9-valent HPV vaccine in the two countries and elsewhere in the English-speaking Caribbean. Use of the study's results to guide the development of policy regarding implementation of HPV testing as the primary screening modality for older women is recommended.
Secular evolution of the vertical column abundances of CHClF2 (HCFC-22) in the Earth's atmosphere inferred from ground-based IR solar observations at the Jungfraujoch and at Kitt Peak, and comparison with model calculations
Zander, R.; Mahieu, E.; Demoulin, PH.; Rinsland, C. P.; Weisenstein, D. K.; Ko, M. K. W.; Sze, N. D.; Gunson, M. R.
Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory, Tucson, Arizona (U.S.A.), from 12/1980 to 04/1992, have been analyzed to provide a comprehensive ensemble of vertical column abundances of CHClF2 (HCFC-22; Freon-22) above the European and the North American continents. The columns were derived from nonlinear least-squares curve fittings between synthetic spectra and the observations containing the unresolved 2 nu(sub 6) Q-branch absorption of CHClF2 at 829.05/cm. The changes versus time observed in these columns were modeled assuming both an exponential and a linear increase with time. The exponential rates of increase at one-sigma uncertainties were found equal to (7.0 +/- 0.35)%/yr for the Junfraujoch data and (7.0 +/- 0.23)%/yr for the Kitt Peak data. The exponential trend of 7.0%/yr found at both stations widely separated in location can be considered as representative of the global increase of the CHClF2 burden in the Earth's atmosphere during the period 1980 to 1992. When assuming two realistic vertical volume mixing ratio profiles for CHClF2 in the troposphere, one quasi constant and the other decreasing by about 13% from the ground to the tropopause, the concentrations for mid-1990 were found to lie between 97 and 111 pptv (parts per trillion by volume) at the 3.58 km altitude of the Jungfraujoch and between 97 and 103 pptv at Kitt Peak, 2.09 km above sea level. Corresponding values derived from calculations using a high vertical resolution-2D model and recently compiled HCFC-22 releases to the atmosphere, were equal to 107 and 105 pptv, respectively, in excellent agreement with the measurements. The model calculated lifetime of CHClF2 was found equal to 15.6 years. The present results are compared critically with similar data found in the literature. On average, the concentrations found here are lower by 15
Lipps, Garth; Lowe, Gillian A; Gibson, Roger C; Halliday, Sharon; Morris, Amrie; Clarke, Nelson; Wilson, Rosemarie N
The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean adolescents. This project examines the association of parenting styles to levels of depressive symptoms among adolescents in Jamaica, the Bahamas, St. Kitts and Nevis, and St. Vincent. Adolescents attending grade ten of academic year 2006/2007 in Jamaica, the Bahamas, St. Vincent, and St. Kitts and Nevis were administered the Parenting Practices Scale along with the BDI-II. Authoritative, Authoritarian, Permissive and Neglectful parenting styles were created using a median split procedure of the monitoring and nurturance subscales of the Parenting Practices Scale. Multiple regression analyses were used to examine the relationships of parenting styles to depressive symptoms. A wide cross-section of tenth grade students in each nation was sampled (n = 1955; 278 from Jamaica, 217 from the Bahamas, 737 St. Kitts and Nevis, 716 from St. Vincent; 52.1% females, 45.6% males and 2.3% no gender reported; age 12 to 19 years, mean = 15.3 yrs, sd = .95 yrs). Nearly half (52.1%) of all adolescents reported mild to severe symptoms of depression with 29.1% reporting moderate to severe symptoms of depression. In general, authoritative and permissive parenting styles were both associated with lower levels of depressive symptoms in adolescents. However, the relationship of parenting styles to depression scores was not consistent across countries (p parenting, caregivers in this study used a mixture of different parenting styles with the two most popular styles being authoritative and neglectful parenting. There appears to be an association between parenting styles and depressive symptoms that is differentially manifested across the islands of Jamaica, the Bahamas, St. Kitts and Nevis and St. Vincent.
Background The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean adolescents. This project examines the association of parenting styles to levels of depressive symptoms among adolescents in Jamaica, the Bahamas, St. Kitts and Nevis, and St. Vincent. Methods Adolescents attending grade ten of academic year 2006/2007 in Jamaica, the Bahamas, St. Vincent, and St. Kitts and Nevis were administered the Parenting Practices Scale along with the BDI-II. Authoritative, Authoritarian, Permissive and Neglectful parenting styles were created using a median split procedure of the monitoring and nurturance subscales of the Parenting Practices Scale. Multiple regression analyses were used to examine the relationships of parenting styles to depressive symptoms. Results A wide cross-section of tenth grade students in each nation was sampled (n = 1955; 278 from Jamaica, 217 from the Bahamas, 737 St. Kitts and Nevis, 716 from St. Vincent; 52.1% females, 45.6% males and 2.3% no gender reported; age 12 to 19 years, mean = 15.3 yrs, sd = .95 yrs). Nearly half (52.1%) of all adolescents reported mild to severe symptoms of depression with 29.1% reporting moderate to severe symptoms of depression. In general, authoritative and permissive parenting styles were both associated with lower levels of depressive symptoms in adolescents. However, the relationship of parenting styles to depression scores was not consistent across countries (p parenting, caregivers in this study used a mixture of different parenting styles with the two most popular styles being authoritative and neglectful parenting. Conclusions There appears to be an association between parenting styles and depressive symptoms that is differentially manifested across the islands of Jamaica, the Bahamas, St. Kitts and Nevis and St
Full Text Available Abstract Background The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean adolescents. This project examines the association of parenting styles to levels of depressive symptoms among adolescents in Jamaica, the Bahamas, St. Kitts and Nevis, and St. Vincent. Methods Adolescents attending grade ten of academic year 2006/2007 in Jamaica, the Bahamas, St. Vincent, and St. Kitts and Nevis were administered the Parenting Practices Scale along with the BDI-II. Authoritative, Authoritarian, Permissive and Neglectful parenting styles were created using a median split procedure of the monitoring and nurturance subscales of the Parenting Practices Scale. Multiple regression analyses were used to examine the relationships of parenting styles to depressive symptoms. Results A wide cross-section of tenth grade students in each nation was sampled (n = 1955; 278 from Jamaica, 217 from the Bahamas, 737 St. Kitts and Nevis, 716 from St. Vincent; 52.1% females, 45.6% males and 2.3% no gender reported; age 12 to 19 years, mean = 15.3 yrs, sd = .95 yrs. Nearly half (52.1% of all adolescents reported mild to severe symptoms of depression with 29.1% reporting moderate to severe symptoms of depression. In general, authoritative and permissive parenting styles were both associated with lower levels of depressive symptoms in adolescents. However, the relationship of parenting styles to depression scores was not consistent across countries (p Conclusions There appears to be an association between parenting styles and depressive symptoms that is differentially manifested across the islands of Jamaica, the Bahamas, St. Kitts and Nevis and St. Vincent.
Lipps Garth; Lowe Gillian A; Gibson Roger C; Halliday Sharon; Morris Amrie; Clarke Nelson; Wilson Rosemarie N
Abstract Background The strategies that parents use to guide and discipline their children may influence their emotional health. Relatively little research has been conducted examining the association of parenting practices to depressive symptoms among Caribbean adolescents. This project examines the association of parenting styles to levels of depressive symptoms among adolescents in Jamaica, the Bahamas, St. Kitts and Nevis, and St. Vincent. Methods Adolescents attending grade ten of academ...
Martinique, Puerto Rico, Saba, St. Barts, St. Eustatius, St. Kitts and Nevis, St. Lucia, St. Maarten, St. Martin , St. Vincent and The Grenadines...M., and S. C. Lindstrom . 2000. North Pacific Seaweeds. Auke Bay, AK: Plant Press. Pratt, V. E. 1991. Wildflowers along the Alaska Highway from...Flora of Texas. Renner, TX: Texas Research Foundation. Volume 1. 1966. Volume 2. 1969. Volume 3. 1961. Martin , W. C., and C. R. Hutchins. 1980
This article aims at analyzing the entry "Monstre", written by Etienne Geoffroy Saint-Hilaire in 1827 and included in the Dictionnaire classique d'histoire naturelle. Under Etienne Geoffroy the study of monsters brought new heuristic and theoretical approaches to the research fields of anatomy and embryology, and acquired the status of a scientific discipline having its own theoreticalfoundations and therefore its own standards for classification, seen as non-random means for revealing a groundbreaking knowledge.
This thesis is oriented on communication strategy of a french hotel Saint Eloi. The goal of this thesis is to provide a reader with a complex view of the Saint Eloi's products and to show him the positive and negative points of communication strategy. The results of this thesis is a creation of a new communication strategy that could help the hotel to restrain in the competitive area and become more popular by using the new communication possibilities.
Rosenthal, Adrienne Isobel; Mayott, Lindsay; Lyons, Daniel Jack; Providence, Karen; Scott, Arlitha; Smart, Ynolde; Katz, Craig L
The Icahn School of Medicine at Mount Sinai and the Saint Vincent/Grenadines Ministry of Health, Wellness and the Environment have been collaborating since 2012 in addressing the plight of alcoholism in Saint Vincent and the Grenadines (SVG). SVG is a middle-income country with few resources available for those who suffer from alcohol use disorders, and these efforts have centered on establishing and monitoring alcohol self-help groups based on the "Alcoholics Anonymous model" (AA model) in several communities in Saint Vincent and the Grenadines. In the summer of 2014, the efforts evolved to include an in-depth investigation of the experience of members of self-help group members via the qualitative research method known as Photovoice. Photovoice is a community based participatory research method in which a set of research questions are explored qualitatively through photographs, interviews, and focus groups. In June 2014, a Photovoice project was established with the longest running self-help group on the island of Saint Vincent in the fishing community of Barrouallie. This project consisted of three rounds of photo-taking, individual interviews, and focus groups, and analysis of the data revealed a number of broad themes relevant to perceptions about the impact of problematic drinking and about drinkers themselves; about the applicability of the AA model in SVG; and about factors that may perpetuate or mitigate problem drinking. It was evident that current and recovering alcoholics believed that there were different types of drinkers who because of their gender, public drinking or tendency for violence could be labeled as "irresponsible." These findings suggest areas for future interventions and research in SVG.
Morin, C; Mitchell, G; Larochelle, J; Lambert, M; Ogier, H; Robinson, B H; De Braekeleer, M
Thirty-four children with lactic acidosis and Leigh encephalopathy due to cytochrome C oxidase (COX) deficiency distributed in 28 families have recently been identified in northeastern Quebec, particularly in the Saguenay-Lac-Saint-Jean (SLSJ) region. The segregation analysis was consistent with an autosomal recessive mode of inheritance. The incidence was estimated at 1/2,063 live births between 1979 and 1990, and the carrier rate was estimated at 1/23 inhabitants in SLSJ. In SLSJ, the place...
Full Text Available The article is extracted from the Master Thesis about Restoration of the Monuments at “La Sapienza”, University of the Studies of Rome. The Monastery was one of the most important of the Dominican Order in Europe. The building dates back to year 1510, it broke down almost completely in the earthquake of year 1659. It was rebuilt following the architect B. Presti’s project. At the present time the “Saint Domenic” Monastery largely seems a ruin, mainly as a consequence of the cat- N. Davolos - A restoration and conservation project of the ÒSaint DominicÓ Monastery... 185 astrophic earthquake in 1783. However, with the new look that has acquired, it still preserves an extraordinary charm that continues to astonish. The project followed the trend of the critical and conservative restoration with the safeguard of the artistic and figurative data of the “Saint Domenic” Monastery which has been analysed through an accurate historical-critical work. The idea is to preserve and transmit to the future generations the “Saint Domenic” monument in his authenticity, in its formal and material consistence, with the marks of the passing of time. The abstracts reports only the most important aspects which are representative of the project. Besides the historical analysis, laboratory examination have been executed on the material used in the construction of the ancient facade through the observation of thin sections by optic microscope and with the realization of spectrum of X-ray diffraction, in order to know the nature and composition, the state of preservation and the kinds of deterioration to support an appropriate intervention of restoration.
Dong, Chao; Li, Xinzheng
The present paper reports five species of squat lobster, genus Agononida Baba and de Saint Laurent, 1996, of which A. squamosa (Henderson, 1885) and A. cf. variabilis (Baba, 1988) were not previously reported in Chinese waters. All the specimens are kept in the Marine Biological Museum collection in the Institute of Oceanology, Chinese Academy of Sciences, Qingdao. To date, there have been 11 species of this genus recorded from China's seas. A key to those species is provided in this paper.
Jung, Philipp; Abdelbary, Mohamed M H; Kraushaar, Britta; Fetsch, Alexandra; Geisel, Jürgen; Herrmann, Mathias; Witte, Wolfgang; Cuny, Christiane; Bischoff, Markus
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) isolates of clonal complex 398 (CC398) are frequently found in Europe, and recent studies highlighted the importance of mobile genetic element (MGE) exchange for host adaptation of this lineage. Of note, one of the MGEs commonly found in human S. aureus isolates, the immune evasion cluster (IEC) harboring bacteriophage Saint3, is very rarely found in LA-MRSA CC398 isolates obtained from farm animals, but more frequently found in LA-MRSA CC398 that were retransmitted to humans. Here, we analyzed with a set of S. aureus CC398 isolates harboring/lacking φSaint3 how this MGE affects (i) phagocytosis of CC398 isolates by polymorphonuclear neutrophils (PMNs), and (ii) hemolysis of human and livestock-derived erythrocytes. Isolates lacking φSaint3 were more efficiently phagocytosed by human PMNs in whole blood phagocytosis assays than isolates harboring this bacteriophage, irrespective of their origin. Notably, a similar effect was observed when equine blood was utilized, but not detected with porcine blood. Integration of φSaint3 into LA-MRSA CC398 strains lacking this MGE confirmed these findings, as φSaint3-harboring recipients were again less efficiently ingested by PMNs in equine and human blood than their parental strains. Integration of φSaint3 strongly reduced the hemolytic potential of the culture supernatants against human-derived erythrocytes, and to a smaller extent also against porcine-derived erythrocytes, while φSaint3 integration only slightly affected the hemolytic capacities against equine-derived red blood cells. The significant protective effect of φSaint3 against phagocytosis by equine PMNs suggests that the host specificity of the IEC components might be broader than currently assumed. Copyright © 2016 Elsevier B.V. All rights reserved.
Moteyunaite I. V.
Full Text Available The article presents a new understanding of such a complex cultural phenomenon as foolishness for Christ through the example of Ludmila Ulitskaya's historical play "The Seven Saints". The author shows that the hero of the 1990's became a blessed woman (a God's fool, who neither sets an optimistic example nor gives faith in the triumph of spirit, but who can only die with dignity, following Christ's way and His final sacrifice.
First Ground-Based Infrared Solar Absorption Measurements of Free Tropospheric Methanol (CH3OH): Multidecade Infrared Time Series from Kitt Peak (31.9 deg N 111.6 deg W): Trend, Seasonal Cycle, and Comparison with Previous Measurements
Rinsland, Curtis P.; Mahieu, Emmanuel; Chiou, Linda; Herbin, Herve
Atmospheric CH3OH (methanol) free tropospheric (2.09-14-km altitude) time series spanning 22 years has been analyzed on the basis of high-spectral resolution infrared solar absorption spectra of the strong vs band recorded from the U.S. National Solar Observatory on Kitt Peak (latitude 31.9degN, 111.6degW, 2.09-km altitude) with a 1-m Fourier transform spectrometer (FTS). The measurements span October 1981 to December 2003 and are the first long time series of CH3OH measurements obtained from the ground. The results were analyzed with SFIT2 version 3.93 and show a factor of three variations with season, a maximum at the beginning of July, a winter minimum, and no statistically significant long-term trend over the measurement time span.
Matheus, Séverine; Chappert, Jean-Loup; Cassadou, Sylvie; Berger, Franck; Labeau, Bhetty; Bremand, Laetitia; Winicki, Alain; Huc-Anais, Patricia; Quenel, Philippe; Dussart, Philippe
To strengthen active dengue surveillance in Saint Martin and Saint Barthélemy, two French Caribbean islands, we evaluated the epidemiological usefulness of collecting blood samples from NS1-positive dengue patients on filter paper to identify the dengue serotypes circulating in these regions during a 27-month period. This approach allowed dengue serotypes to be identified by reverse transcriptase-polymerase chain reaction in 90.1% of the total set of 666 samples analyzed and, in 95.5% of the samples collected during the acute phase of the disease. This prospective virological surveillance using blood samples absorbed onto filter paper, which were stored at 4°C and shipped at ambient temperature to a specialized laboratory for analysis, allowed us to avoid the logistic and financial costs associated with shipping frozen venous blood samples. This surveillance system offers a low-cost alternative for reinforcing dengue prevention in areas where specialized laboratories do not exist, notably by facilitating the early detection of potentially new dengue serotypes. PMID:22232467
Madagascar , Maldives, Malta, Marshall Islands , Mauritius, Micronesia, Nauru, New Zealand, Palau, Philippines, Qatar, Saint Kitts and Nevis, Saint...held territory in central Italy centered on Rome, the Kingdom of Piedmont-Sardinia held the island of Sardinia and northwestern Italy centered on...the city of Turin, and the Kingdom of Two Sicilies was located in southern Italy and the island of Sicily. 7
Chen, Yumei; Klonowski, Paul W; Lind, Anne C; Lu, Dongsi
Neurotized melanocytic nevi and neurofibromas are common, benign cutaneous neoplasms. Usually they are histologically distinct from each other; however, neurotized melanocytic nevi and neurofibromas can be clinically and histologically similar. To determine whether Melan-A (MART-1) immunohistochemical stain is sufficient to differentiate neurotized melanocytic nevi from neurofibromas. Forty-nine consecutive specimens of melanocytic nevi with neurotization and 49 specimens of neurofibromas were selected. We used antibodies against Melan-A, S100, and neurofilament protein. All of the melanocytic nevi showed Melan-A staining within the neurotized areas, with most of the areas staining strongly positive, whereas all the neurofibromas were completely absent of Melan-A stain. All of the nevi, including the neurotized areas, stained strongly and diffusely for S100, whereas all the neurofibromas showed a distinctive, sharp, wavy pattern of S100 staining. Neurofilament protein showed scattered staining of both melanocytic nevi and neurofibromas. Our data indicate that Melan-A immunohistochemical staining is helpful in differentiating neurotized melanocytic nevi from neurofibromas when distinction on histomorphology alone is difficult.
Full Text Available Objective: The aim of our study was to evaluate the changes of the melanocytic nevi during the biological agent therapy. Methods: For this purpose, 40 index nevi of 25 adult patients who were treated with infliximab, adalimumab, etanercept or rituximab were included in this study. All of the patients underwent clinical and dermoscopic evaluation before the beginning of the treatment, 6 months and 1 year after the beginning of the treatment. Among dermoscopic examination methods, pattern analysis, ABCD score system and three-point checklist were performed. Results: In terms of the diameter of the index nevi, there was no statistically significant difference between the first examination and that of the sixth month, but differences was observed between the first examination and that of the twelfth month. There was also no statistically significant difference in total dermoscopy scores calculated by ABCD score system application on 31 nevi at the times of assessment. At the end of the study, we detected 24 new nevi formation in 7 patients, whom all of were over 35 years of age, however no eruptive nevi or melanoma formation were observed. Conclusion: An increase in the diameters of the present nevi and formation of new nevi may be seen with biological agent therapy in one-year-follow-up.
Dusza, Stephen W; Delgado, Ruby; Busam, Klaus J; Marghoob, Ashfaq A; Halpern, Allan C
To assess the clinical and histologic effects of topical imiquimod therapy on dysplastic nevi, and to determine the feasibility of using in vivo confocal microscopy (CSLM) to non-invasively monitor histological response of dysplastic nevi to imiquimod therapy. Single-blinded pilot study with patients not blinded as to treatment status. Dermatology Outpatient Clinic, Memorial Sloan-Kettering Cancer Center, New York, NY. The study population comprised of 10 patients with clinically dysplastic (atypical) nevi and at least 8 large nevi, (> or =5 mm) on their trunk. Sixteen weeks of imiquimod 5% cream applied to treatment lesions 3 times per week. Clinical response as gauged by comparison of baseline and week 20 1:1 standardized photographs for all study nevi and histological assessment of each patient's 4 largest study nevi at completion of therapy. There were no obvious clinical changes in the size and morphology of the study nevi. Subtle changes in nevus color could not be assessed due to imperfect spectral registration of images over the course of the study. Histologically, 4 of 14 treated nevi and 0 of 14 untreated nevi p=0.03 showed a significant relative reduction of junctional and intraepidermal nevocytes accompanied by papillary dermal fibroses and variable inflammation suggestive of partial regression. Non-invasive CSLM imaging of study nevi demonstrated previously reported in vivo features of dysplastic nevi. but the imaging equipment and protocol utilized proved inconsistent across lesions and time. The histological changes seen in a subset of treated nevi suggest a possible role for the use of topical immune response modifiers for the treatment of dysplastic nevi with the intent of melanoma chemoprevention. The dose regimen of topical imiquimod utilized in this study failed to induce sufficient clinical or histological responses to warrant further study. Targeting of dysplastic nevi and intermediate endpoints for melanoma chemoprevention with more intense
Full Text Available Kabir Sardana, Payal Chakravarty, Khushbu Goel Department of Dermatology and STD, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, Delhi, India Abstract: Although common acquired melanocytic nevi are largely benign, they are probably one of the most common indications for cosmetic surgery encountered by dermatologists. With recent advances, noninvasive tools can largely determine the potential for malignancy, although they cannot supplant histology. Although surgical shave excision with its myriad modifications has been in vogue for decades, the lack of an adequate histological sample, the largely blind nature of the procedure, and the possibility of recurrence are persisting issues. Pigment-specific lasers were initially used in the Q-switched mode, which was based on the thermal relaxation time of the melanocyte (size 7 µm; 1 µsec, which is not the primary target in melanocytic nevus. The cluster of nevus cells (100 µm probably lends itself to treatment with a millisecond laser rather than a nanosecond laser. Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG] are more suited to treat acquired melanocytic nevi. The complexities of treating this disorder can be overcome by following a structured approach by using lasers that achieve the appropriate depth to treat the three subtypes of nevi: junctional, compound, and dermal. Thus, junctional nevi respond to Q-switched/normal mode pigment lasers, where for the compound and dermal nevi, pulsed ablative laser (CO2/Er:YAG may be needed. If surgical excision is employed, a wide margin and proper depth must be ensured, which is skill dependent. A lifelong follow-up for recurrence and melanoma is warranted in predisposed individuals, although melanoma is decidedly uncommon in most acquired melanocytic nevi, even though histological markers may be seen on evaluation. Keywords: lasers, surgery, nevus, melanoma
Full Text Available Noi siamo la generazione post-socialista, la generazione del dopo guerra fredda, della fine delle burocrazie verticali e del controllo sull'informazione. Siamo un movimento globale e neuropeo, che porta avanti la rivoluzione democratica scaturita dal Sessantotto mondiale e lotta contro la distopia neoliberista oggi al culmine. Siamo ecoattivisti e mediattivisti, siamo i libertari della Rete e i metroradicali dello spazio urbano, siamo le mutazioni transgender del femminismo globale, siamo gli hacker del terribile reale. Siamo gli agitatori del precariato e gli insorti del cognitariato. Siamo anarcosindacalisti e postsocialisti. Siamo tutti migranti alla ricerca di una vita migliore. E non ci iconosciamo in voi, stratificazioni tetre e tetragone di ceti politici sconfitti già nel XX secolo. Non ci riconosciamo nella sinistra italyana.Manifesto Bio/Pop del Precariato Metroradicale, 20042004 has marked the beginning of the spreading "cult" of San Precario, Patron Saint of precarious, casual, sessional, temporary, flexible and fractional workers. The Saint appears in public spaces in occasion of rallies, marches, interventions and demonstrations, and its popularity has lead to development of a precise and colorful iconography, hagiography and rituals. This popularity conversely is also the sign of the gravity of the issue of precarity in Italy and Europe .San Precario epitomises current Italian activist practices. These practices, although specifically Italian, intersect with similar realities in Europe and are based on mythopoetic narratives and actions and mediatic embodiments. This paper analysis a variety of texts produced around San Precario, from posters, saint cards, product cards, videos, "official" narratives, personal accounts, relating them to the political debate surrounding precarity.
Organization of American States, Washington, DC.
This document outlines the existing conditions of school buildings and their vulnerability to natural hazards on the island of St. Kitts, and makes recommendations on how to better protect them from these hazards. Profiles of the schools are detailed and the roles and responsibilities of the various organizations concerning construction,…
Shim, Joo Hyun; Seo, Seong Jun; Song, Kye Yong; Hong, Chang Kwun
Nevus depigmentosus is a stable and well-circumscribed congenital hypomelanosis that may be in an isolated, dermatomal or systemic form. An 18-yr-old Korean man with segmental nevus depigmentosus developed multiple pigmented nevi which were present only within the confines of the leukoderma. Histologic and electron microscopic studies rendered a diagnosis of nevus depigmentosus with dysplastic nevus to the patient. The genetic alteration of melanocytes in the hypopigmented lesion is assumed to have resulted in the development of multiple pigmented nevi.
Robinson, W. G.; Schechter, P. L.; Janes, C. C.
The results of trial runs using telephone links to the Kitt Peak Observatory to permit astronomers to make use of the instrumentation from remote sites are reported. Three lines permit voice communication with the telescope operator, interfacing with the telescope computer, and television hook-up to the telescope image acquisition system. One complete picture frame is furnished every 34 sec over the modem. A commercial direct-dial long distance line was found to have a relatively acceptable noise level. The best operation was performed using the intensified image dissector scanner on a 2.1 m telescope. Satisfactory operation and controllability was reported from a user located over a thousand miles away. Further attempts will be made to add a CCD system and a Fourier transform spectrometer to the equipment that can be remotely operated. An expansion in the communications equipment and collaborative programs with other observatories are recommended in order to expand the program to more users.
Momsen, J D
The relationship between migration and agricultural development in the Caribbean is examined. The data, collected by survey, concern the islands of Nevis, Montserrat, and Saint Lucia. The results show that migration is not associated with agricultural innovation or the use of specific technical inputs and that it frequently has a negative impact on agricultural productivity and attitudes toward farming.
Sada, Pedro V.; Deming, Drake; Jennings, Donald E.; Jackson, Brian k.; Hamilton, Catrina M.; Fraine, Jonathan; Peterson, Steven W.; Haase, Flynn; Bays, Kevin; Lunsford, Allen; O'Gorman, Eamon
We obtained J-, H-, and JH-band photometry of known extrasolar planet transiting systems at the 2.1 m Kitt Peak National Observatory Telescope using the FLAMINGOS infrared camera between 2008 October and 2011 October. From the derived light curves we have extracted the midtransit times, transit depths and transit durations for these events. The precise midtransit times obtained help improve the orbital periods and also constrain transit-time variations of the systems. For most cases the published system parameters successfully accounted for our observed light curves, but in some instances we derive improved planetary radii and orbital periods. We complemented our 2.1 m infrared observations using CCD z‧-band and B-band photometry (plus two Hα filter observations) obtained with the Kitt Peak Visitor Center Telescope, and with four H-band transits observed in 2007 October with the NSO’s 1.6 m McMath-Pierce Solar Telescope. The principal highlights of our results are (1) Our ensemble of J-band planetary radii agree with optical radii, with the best-fit relation being (Rp/R∗)J = 0.0017 + 0.979(Rp/R∗)vis. (2) We observe starspot crossings during the transit of WASP-11/HAT-P-10. (3) We detect starspot crossings by HAT-P-11b (Kepler-3b), thus confirming that the magnetic evolution of the stellar active regions can be monitored even after the Kepler mission has ended. (4) We confirm a grazing transit for HAT-P-27/WASP-40. In total, we present 57 individual transits of 32 known exoplanet systems.
Matt Griffin; Sylvie Quiniou; Cynthia Ware; Lewis Bogdanovic; Esteban Soto
.... Kitts. Myxospores were consistent with quadrate members of the Kudoidae, measuring 8.8 (8.2–9.4) μm wide, 7.3 (6.6–8.3) μm thick, and 6.2 (5.8–6.9) μm long with 4 uniform drop-like polar capsules measuring...
Siskind, Victor; Hughes, Maria Celia B; Palmer, Jane M; Symmons, Judith M; Aitken, Joanne F; Martin, Nicholas G; Hayward, Nicholas K; Whiteman, David C
Although risk factors for primary cutaneous melanoma are well defined, relatively little is known about predictors for second primary melanoma. Given the rising incidence of this cancer, coupled with improvements in survival, there is a prevalent and growing pool of patients at risk of second primary melanomas. To identify the predictors of second primary melanoma, we followed a cohort of 1,083 Queensland patients diagnosed with incident melanoma between 1982 and 1990 and who completed a baseline questionnaire. During a median follow-up of 16.5 years, 221 patients were diagnosed with at least one additional primary melanoma. In multivariate analyses, second primary melanomas were associated with high nevus count (hazard ratio (HR), 2.91; 95% confidence interval (CI) 1.94-4.35), high familial melanoma risk (HR, 2.12; 95% CI 1.34-3.36), fair skin (HR, 1.51; 95% CI 1.06-2.16), inability to tan (HR, 1.66; 95% CI 1.13-2.43), an in situ first primary melanoma (HR, 1.36; 95% CI 0.99-1.87), and male sex (HR, 1.49; 95% CI 1.12-2.00). Patients whose first primary was lentigo maligna melanoma (HR, 1.80; 95% CI 1.05-3.07) or nodular melanoma (HR, 2.13; 95% CI 1.21-3.74) had higher risks of subsequent primaries than patients whose first primary tumor was superficial spreading melanoma. These characteristics could be assessed in patients presenting with first primary melanoma to evaluate risk of developing a second primary.
Wighton, Paul; Lee, Tim K.; McLean, David; Lui, Harvey; Atkins, M. Stella
Texture is known to predict atypicality in pigmented skin lesions. This paper describes an experiment that was conducted to determine 1) if this textural information is present in the center of skin lesions, and 2) how color affects the perception of this information. Images of pigmented skin lesions from three categories were shown to subjects in such a way that only textural information could be perceived; other factors known to predict atypicality were removed or held constant. These images were shown in both color and grayscale. Each subject assigned a score of atypicality to each image. The experiment was conducted on 5 subjects of varying backgrounds, including one expert. Each subject's accuracy under each modality was measured by calculating the volume under a 3-way ROC surface. The modalities were compared using the Dorfman-Berbaum-Metz (DBM) method of ROC analysis, giving a p-value of 0.8611. Therefore the null hypothesis that there is no difference between the predictive power of the modalities cannot be rejected. Also, a two one-sided test of equivalence (TOST) was performed giving a p-value pair of pigmented skin lesions.
María-Dolores Fernández-Poyatos, Ph.D.
Full Text Available This article analyses the tourism websites of Spanish autonomous communities crossed by the Way of Saint James. Considering that the Way of Saint James and the Xacobeo 2010 are important touristic opportunities for these autonomous regions, the main objective of this investigation is to evaluate the information about these touristic places in their tourism websites. The analysis focused on two aspects: firstly, establishing whether the autonomous communities have used the Way of Saint James and the Xacobeo 2010 to promote themselves, and secondly, evaluating the quality of the websites. The study included a literature review, definition of concepts and criteria to measure the quality of websites, and the analysis of the content and design of the selected tourism websites. The results show that the Galician website is the most complete in terms of information about the Way of Saint James and the Xacobeo 2010. The information about the Way of Saint James and the Xacobeo 2010 in the websites of the other communities is vague and differs from one website to another. Due to the touristic significance of the Xacobeo 2010 and the importance of Internet as a medium of communication, the research group plans to conduct a new analysis of the communities’ institutional websites in 2011.
Madden, Tessa; Allsworth, Jenifer E.; Hladky, Katherine J.; Secura, Gina M.; Peipert, Jeffrey F.
Background Many obstacles to intrauterine contraception use exist, including provider and patient misinformation, high upfront cost, and clinician practice patterns. The aim of our study was to investigate knowledge and attitudes about intrauterine contraception among obstetricians and gynecologists in the area of Saint Louis. Study Design We mailed a self-administered, anonymous survey to 250 clinicians who provide obstetric and gynecologic care in Saint Louis City and County which included questions about demographics, training, family planning visits, and intrauterine contraceptive knowledge and use. Results The overall survey response rate among eligible clinicians was 73.7%. Clinicians who had recently finished training or saw higher numbers of contraceptive patients per week were more likely to insert intrauterine contraception than clinicians who completed training prior to 1989 or saw fewer contraceptive patients. Several misconceptions among clinicians were identified, including an association between intrauterine contraceptives and an elevated risk of pelvic inflammatory disease. Conclusions Physician misconceptions about the risks of intrauterine contraception continue to occur. Improved clinician education is greatly needed to facilitate the use of these highly effective, long-acting, reversible methods of contraception. PMID:20103447
Xiong, Xi-Xi; Ding, Gao-Zhong; Zhao, Wen-E; Li, Xue; Ling, Yu-Ting; Sun, Li; Gong, Qing-Li; Lu, Yan
Skin color is determined by the number of melanin granules produced by melanocytes that are transferred to keratinocytes. Melanin synthesis and the distribution of melanosomes to keratinocytes within the epidermal melanin unit (EMU) within the skin of vitiligo patients have been poorly studied. The ultrastructure and distribution of melanosomes in melanocytes and surrounding keratinocytes in perilesional vitiligo and normal skin were investigated using transmission electron microscopy (TEM). Furthermore, we performed a quantitative analysis of melanosome distribution within the EMUs with scatter plot. Melanosome count within keratinocytes increased significantly compared with melanocytes in perilesional stable vitiligo (P < 0.001), perilesional halo nevi (P < 0.01) and the controls (P < 0.01), but not in perilesional active vitiligo. Furthermore, melanosome counts within melanocytes and their surrounding keratinocytes in perilesional active vitiligo skin decreased significantly compared with the other groups. In addition, taking the means-standard error of melanosome count within melanocytes and keratinocytes in healthy controls as a normal lower limit, EMUs were graded into 3 stages (I-III). Perilesional active vitiligo presented a significantly different constitution in stages compared to other groups (P < 0.001). The distribution and constitution of melanosomes were normal in halo nevi. Impaired melanin synthesis and melanosome transfer are involved in the pathogenesis of vitiligo. Active vitiligo varies in stages and in stage II, EMUs are slightly impaired, but can be resuscitated, providing a golden opportunity with the potential to achieve desired repigmentation with an appropriate therapeutic choice. Adverse milieu may also contribute to the low melanosome count in keratinocytes.
National Park Service, Department of the Interior — These ESRI shape files are of National Park Service tract and boundary data that was created by the Land Resources Division. Tracts are numbered and created by the...
Full Text Available The extent to which Marine Protected Areas (MPAs benefit corals is contentious. On one hand, MPAs could enhance coral growth and survival through increases in herbivory within their borders; on the other, they are unlikely to prevent disturbances, such as terrestrial runoff, that originate outside their boundaries. We examined the effect of spatial protection and terrestrial sediment on the benthic composition of coral reefs in Saint Lucia. In 2011 (10 to 16 years after MPAs were created, we resurveyed 21 reefs that had been surveyed in 2001 and analyzed current benthic assemblages as well as changes in benthic cover over that decade in relation to protection status, terrestrial sediment influence (measured as the proportion of terrigenous material in reef-associated sediment and depth. The cover of all benthic biotic components has changed significantly over the decade, including a decline in coral and increase in macroalgae. Protection status was not a significant predictor of either current benthic composition or changes in composition, but current cover and change in cover of several components were related to terrigenous content of sediment deposited recently. Sites with a higher proportion of terrigenous sediment had lower current coral cover, higher macroalgal cover and greater coral declines. Our results suggest that terrestrial sediment is an important factor in the recent degradation of coral reefs in Saint Lucia and that the current MPA network should be complemented by measures to reduce runoff from land.
Full Text Available St. Lucia is an island nation in the Eastern Caribbean, with a population of 179,000 people, where chronic health conditions, such as hypertension and diabetes, are significant. The purpose of this pilot study is to create a model for community health education, tracking, and monitoring of these health conditions, research training, and policy interventions in St. Lucia, which may apply to other Caribbean populations, including those in the U.S. This paper reports on phase one of the study, which utilized a mixed method analytic approach. Adult clients at risk for, or diagnosed with, diabetes (n = 157, and health care providers/clinic administrators (n = 42, were recruited from five healthcare facilities in St. Lucia to assess their views on health status, health services, and improving health equity. Preliminary content analyses indicated that patients and providers acknowledge the relatively high prevalence of diabetes and other chronic illnesses, recognize the impact that socioeconomic status has on health outcomes, and desire improved access to healthcare and improvements to healthcare infrastructures. These findings could inform strategies, such as community education and workforce development, which may help improve health outcomes among St. Lucians with chronic health conditions, and inform similar efforts among other selected populations.
Full Text Available Time as a narrative category arises from the temporary status of any narrative by which the narrative language is oriented towards processes that are based on temporality. Time thus becomes one of the fundamental aspects of any narrative. Although the style of Teresa’s texts is characterised by the tone of oral conversation, this does not exclude her concern with the form and organisation of her writings. Our main concern is time from two different perspectives; on the one hand, as a component of the story and on the other, as its manifestation on the level of discourse. First, we analyse the relationships and the discrepancies in the works of St. Teresa of Avila between the discourse time and the story time, using three parameters: order, duration and frequency (Genette, 1972. Secondly, we examine different kinds of narration in the works of Saint Teresa to establish whether the majority of them are subsequent (ulterior, prior (anterior, simultaneous or interpolated (intercalated. Contrasting story time and discourse time in the works of Saint Teresa, we note the agility of her literary style and her ability to organize narrative syntax.
Marr, John S; Cathey, John T
Epidemics have been pivotal in the history of the world as exemplified by a yellow fever epidemic in the Caribbean that clearly altered New World geopolitics. By the end of the 18th century, yellow fever--then an "emerging disease"--was widespread throughout the Caribbean and particularly lethal in Saint-Domingue (present day Haiti). From 1793 to 1798, case fatality rates among British troops in the West Indies (including Saint-Domingue) were as high as 70%. A worse fate befell newly arrived French armed forces in 1802, ostensibly sent by Napoleon to suppress a rebellion and to reestablish slavery. Historians have disagreed on why Napoleon initially dispatched nearly 30,000 soldiers and sailors to the island. Evidence suggests the troops were actually an expeditionary force with intensions to invade North America through New Orleans and to establish a major holding in the Mississippi valley. However, lacking knowledge of basic prevention and control measures, mortality from the disease left only a small and shattered fraction of his troops alive, thwarting his secret ambition to colonize and hold French-held lands, which later became better known as the Louisiana Purchase. If an event of the magnitude of France's experience were to occur in the 21st century, it might also have profound unanticipated consequences.
International students share a host of problems. For many, it is the first time they leave home and soon discover that their new host country has traditions, cultures, and educational standards that differ from their own. The initial excitement upon arrival is often followed by a difficult period of adjustment. As university instructors, we must…
Henrieta Anişoara ŞERBAN
Full Text Available 2016 is an anniversary year, dedicated to the Saint Hierarch Anthim, a multi-faced personality of Georgian origin, but with a Romanian accomplished life. He was a true Orthodox believer, a Hierarch of our Orthodox Church in Wallachia and a deep thinker, who lived through the teachings of the faith. At the same time, he was a good manager and a philanthropist, a scholar, a polyglot, a calligrapher, a typographer, a Church architect, an orator turned writer, a painter and a sculptor. His great homiletic work entitled Didahiile sends to Didache, the oldest post-Bible Christian text, famous at Constantinople, known also as The Teachings of the Twelve Apostles (The Teachings of the Lord to the Gentiles (or Nations by the Twelve Apostles. The study approaches and develops these dimensions of the personality and of the thought of the Saint Hierarch Anthim, in order to emphasize both his life and his work as an esteemed symbol of the Orthodox faith.
Pavenkov Oleg Vladimirovich
Full Text Available The article deals with the analysis of concept “love” in theology of St. Augustine. Theology of love of St. Augustine was influenced by many things, especially the Christian Nikean creed and personal spiritual experience. In our article we delved deeply in the united trinitology and agapelogy parts of Augustine's teaching. We described the forms of connection between the Trinity and the Christian love in Augustine's dogmatic system. We revealed the characteristic feature of Augustine's theology of love: love is not only a commandment or quality of Divine reality, but the essence of God.
%), and renal failure 46 (5.5%). Mean duration of ... acute febrile illnesses, gastrointestinal infections, pulmonary infections as the leading causes of medical admissions (5). The other study conducted at Gondar Teaching hospital from. 1971 to ...
Janković, S M; Sokić, D V; Lević, Z M; Susić, V; Stojsavljević, N; Drulović, J
From a historic point of view, epilepsy and its eponyms were in an ontogenetic symbiosis throughout their history. Epilepsy is a disease with a history of eponyms presenting the frame of mind of both streetwise as well as skilled "authors" about its origin and nature. From ancient times the names for epilepsy, archetypal Hippocratic disease, just as rich in number as varied in their implication, reflected the local folkways of thinking. In this article we briefly presented more than 50 eponyms and patrons of epilepsy. As the source of information we used both the apocryphal, canonical and hagiographic as well as heretic literature, legends and iconography from the Middle Ages of domestic and foreign origin. Pre- and post-Hippocratic era, apart from stemming from the oldest written medical sources, point to the position that the disease had organic origin located in the brain. The period of Rome adopted the attitudes set by Galen which remained en vogue throughout the emerging Middle Ages and Renaissance. These eras generated new eponyms which reflected a downfall in the manor, stating that the disease is the consequence of supernatural forces. In the "Age of darkness" eponyms for epilepsy reflected more the relation of men to the Nature than to the disease or a sick man; this is evidenced through the generation of number of patrons for the disease. The most famous patron of patients with epilepsy was St. Valentine (after conversion from pagandom he died in Rome as a martyr, c. 270). He was allotted a patronage either due to the phonic resemblance of his name with the (past participle of the) verb "fallen"-as Martin Luther claimed, or due to a cure of epilepsy of the son of a Roman rhetor who built for him a chapel in which he continued to cure the sick. The emergence of a flamboyant personality of Paracelsus on the historic scene of the XVI century represents a less successful attempt to revoke the way of thinking set by the old Greek doctors; however, it brought
wing 71 extremist. The rise of Liberation Theology in Guatemala received its momentum from the Maryknoll’s Cursillos de Capacitacion . This program...34Guatemala," pp. 312-313. 71. Summarized from Ibid, p. 313. 72. Information on the Cursillos de Capacitacion and the quote were taken from Michael
This paper explores the practice of Islam among a relatively understudied group of Muslim migrants in France, the Halpulaaren, some of whom have been living in France for more than three decades. Drawing on field research in Senegal, Mali and France, the author considers the contexts for Halpulaaren
Kjærgård, Jonas Ross
is seen through a distinctly Parisian lens. The first consequence of this framing is an omission of specifically Haitian concerns. The second is a particular infusion of colonial problems into metropolitan discussions. In analyzing this reciprocal transportation of figures and discourse, the article shows...
Full Text Available La collégiale Saint-Étienne à Neuvy-Saint-Sépulchre (Indre est un des rares édifices subsistants en France qui soit conçu comme une copie de l’église du Saint-Sépulcre de Jérusalem. L’étude archéologique, réalisée pendant des travaux, a permis de préciser les étapes de son évolution depuis sa fondation dans les années 1040. La rotonde, avec ses onze piliers centraux, a été ajoutée à l’extrémité ouest d’une église antérieure. Le mur extérieur a été achevé dans cette première phase mais la cage centrale, qui abritait l’édicule, n’a été terminée qu’au début du XIIe s. Pendant la deuxième moitié du XIIe s., l’église est profondément remaniée et sans doute raccourcie avec la création d’un chevet plat. La voûte primitive est remplacée par trois travées de croisées d’ogives. L’édifice sert de refuge pendant la guerre de Cent Ans, ce qui provoque certains dégâts, partiellement réparés. Malgré les ruptures évidentes dans la construction et un plan irrégulier, l’étude montre que l’édifice est le résultat de la poursuite d’un projet architectural cohérent et original visant à évoquer l’église du Saint-Sépulcre de Jérusalem.The collegiate church of Saint-Étienne at Neuvy-Saint-Sépulchre (Department of the Indre, France is one of the few surviving rotundas built as a copy of the Holy-Sepulcre of Jerusalem during the mid 11th century. Many theories have been advanced concerning the history and the dating of this unusual monument. A recent building survey, carried out during restoration work, has managed to clarify the main phases of its evolution. The rotunda, with eleven central pillars placed around the reliquary monument, was added onto the west end of an existing church during the 1040’s. The two upper stories of the central cage, however, were not finished until the early 12th century. During the second half of the 12th century, the church was extensively
Chaplin, Eddie; Chester, Rebecca; Tsakanikos, Elias; McCarthy, Jane; Craig, Tom; Bouras, Nick
This study investigated the main psychometric properties of the Self Assessment and Intervention (SAINT), a unique and recently developed Guided Self-Help tool for people with intellectual disabilities (ID). Fifty-four adults with ID identified with symptoms of anxiety and/or depression completed the study. They were between 18 and 77 years old…
... COMMISSION 47 CFR Part 73 Radio Broadcasting Services; Alberton, MT; Crystal Falls, MI; Saint Paul, AR; and... Paul, Arkansas a vacant allotment. List of Subjects in 47 CFR Part 73 Radio, Radio broadcasting...: PART 73--RADIO BROADCAST SERVICES 0 1. The authority citation for part 73 continues to read as follows...
Jović, Nebojša J; Theologou, Marios
The Christian miracle tales strongly support the identification of Sts. Cosmas and Damian as doctors. The most famous of the saints' posthumous miracles, is that of the Black Leg. The main source of this story is the Golden Legend by Jacobus da Varagine, collection of fanciful hagiographies compiled in the 13th century. Saints Cosmas and Damian miraculously transplanted the black leg of the Ethiopian man onto the white body of the verger with "cancerous" leg. Saints appeared to the patient in a dream, amputated his diseased leg and replaced it with the leg of a recently died man. This dramatic cure was attractive for many western artists. The iconography of this miracle was depicted for the first time in a Florentine panel of ca.1370. The color of the leg later attracted special attention. Since the 1990's the Miracle of the Black Leg, presented in a (neo) Byzantine style, appeared in Greece. The miracle of Holy Unmercenaries has no proper historical foundation in the Books of the lives of the Saints in the Orthodox Churches. Action focused on replacement of the affected leg with one from cadaveric donor was unknown to the eastern Christianity. Exploration of available orthodox hagiographical sources related to the healing powers of Sts. Cosmas and Damian showed remarkable neglect of that miracle. Some contemporary Greek authors find appropriate to disregard it.
Freire, A S; Pinheiro, M A. A; Karam-Silva, H; Teschima, M M
.... The low diversity of food items, absence of predators of large crabs and high geographic isolation are the determinants of unique behavioural and biological characteristics observed in the G. grapsus population.
Quintela, Marco V. García; García, A. César González; Veiga, Yolanda Seoane
We present three Iron Age landscapes in the province of Ourense (northwest Spain), consisting of a hill fort with an acropolis used for religious purposes, and an "extra-urban" location used for ritual functions. Both locations are associated with the solstices, corroborating the validity of considering them jointly in each case, and the three cases jointly as a model. In the three locations, the oldest Christian saints and festivals we are able to identify re-use the dates of the solstices, and others, marked by Iron Age monuments. These observations open the way for research in several directions: the definition of religious landscapes from the Iron Age; the reason why there is not a 'Roman landscape'; the relationship between the Indo-European legacy and the introduction of Christianity; and the relationship between local calendars and the Celtic, Julian and Gregorian 'cultural' calendars.
Full Text Available This article is focused on underground architecture design analysis, considering energy efficiency, green technologies, building structure optimization and other questions in Russia (Saint-Petersburg and China (Harbin. Today, when our society advocatesfor the sustainable development and ecological architecture, the ecotypic underground architecture is an unavoidable theme. There were called some advantages and disadvantages of ecological design implementation methods – influence on environment and human behavior. Conclusion based on underground architectural design technologies comparison between contemporary public building construction experience in Russia and China. General plan of the using of underground urban spaces is not existat all, despite the fact that excluding of the same plan forbids any ground construction.There was given a long-time prognosis about underground architecture development - some perspectives and possible results in future.
Full Text Available The paper has been based on archaeological and architectural exploration of the church in Żębocin carried out in 2011. Żębocin, a village in the Miechów district and the Proszowice deanery, had its beginnings reportedly in the mid-11th century. However, the first squire of Żębocin documented in historical sources was Tomko, coat of arms unknown, mentioned in 1384. According to tradition, the first church in the village, which has not survived, was built in the years 1059–1071 and consecrated by St. Stanislas of Szczepanów. In a local legend, the wife of knight Mikołaj of Żębocin took shelter in the tower of a stone church in Żębocin during the unrest in the reign of Boleslaus the Brave. The stone foundation under the north-eastern corner of the chancel belonged probably to a stone building, its function unknown, which may have stood there already in those turbulent times. The extant church, erected in the mid-13th century or soon afterwards, was a small single-nave structure with a chancel closed with a straight wall, built from bricks (with a wendian bond pattern on its elevation on stone foundations. It combined two styles: Romanesque (as shown by the surviving splayed window in the northern elevation of the chancel and Gothic (the brick ogival frame in the northern elevation of the nave. The important question whether the church had a tower from the start and where that tower was located remains undecided; the tower could have been incorporated into the body of the nave from the west or built above the chancel; it could also have been added afterwards, in the 16th century at the latest. Reportedly, the church in Żębocin once had a defensive character and was located in knights’ fortified town. Its founder may have been a progenitor of the Strzemieńczyk or the Odrowąż families. It should be remembered that Romanesque single-nave “village” churches built on a simple plan are quite frequent in Central Europe; there are
Full Text Available This article discusses recent changes in Catholic festivities, especially the system of fiestas in rural Mexico. The ethnographic focus of the discussion is on indigenous Zapotec communities of the State of Oaxaca. Collective religious practices in Mexican villages contribute to social cohesion. Fiestas commemorating patron saints of the villages play a particularly important role in (reconstructing communal identity and the feeling of collective belongingness. Various global processes like secularisation, integration of local economies into the capitalist market system, increasing out-migration from villages, and the rise of Protestantism have undermined the position of the Catholic Church in the region. The article scrutinises the changing organisation and role of fiestas in the communities, concluding that the impact of secularisation, migration and Protestantism in particular is not simple and always negative – these changes can actually invigorate certain dimensions of the fiestas.
Full Text Available The Cape Saint Paul Wilt Disease (CSPWD, a lethal-yellowing type disease of coconut has been in Ghana since 1932. Aerial and/or ground surveys were undertaken to assess the current status of the disease spread. The survey showed that the spread of the disease for the past 5 years has mainly been the expansion of existing foci. However, new outbreaks were identified at Glidzi in the Volta, Bawjiase and Efutu Breman in Central regions. After the resurgence in the Volta region in 1995, the Woe-Tegbi-Dzelukope corridor has remained endemic, but less aggressive. Pockets of healthy groves remain along all the coastline and inland of known disease zones. Eradication of diseased palms at Ampain focus lying just about 60 km to the Ivorian border, and disease situations on new replanting with MYD × VTT hybrid are discussed.
Prichard, Carson G.; Craig, Jaquelyn M.; Roseman, Edward F.; Fischer, Jason L.; Manny, Bruce A.; Kennedy, Gregory W.
A long-term, multiseason, fish egg sampling program conducted annually on the Detroit (2005–14) and Saint Clair (2010–14) Rivers was summarized to identify where productive fish spawning habitat currently exists. Egg mats were placed on the river bottom during the spring and fall at historic spawning areas and candidate fish spawning habitat restoration sites throughout both rivers. Widespread evidence was found of lithophilic spawning by numerous native fish species, including walleye (Sander vitreus), lake whitefish (Coregonus clupeaformis), lake sturgeon (Acipenser fulvescens), suckers (Catostomidae spp.), and trout-perch (Percopsis omiscomaycus). Walleye, lake whitefish, and suckers spp. spawned in nearly every region of each river in all years on both reef and nonreef substrates. Lake sturgeon eggs were collected almost exclusively over constructed reefs. Catch-per-unit effort of walleye, lake whitefish, and sucker eggs was much greater in the Detroit River than in the Saint Clair River, while Saint Clair River sites supported the greatest collections of lake sturgeon eggs. Collections during this study of lake sturgeon eggs on man-made spawning reefs suggest that artificial reefs may be an effective tool for restoring fish populations in the Detroit and Saint Clair Rivers; however, the quick response of lake sturgeon to spawn on newly constructed reefs and the fact that walleye, lake whitefish, and sucker eggs were often collected over substrate with little interstitial space to protect eggs from siltation and predators suggests that lack of suitable spawning habitat may continue to limit reproduction of lithophilic-spawning fish species in the Saint Clair-Detroit River System.
Rafael CASTAÑEDA GARCÍA
Full Text Available The focus of this article is the hagiographies and novenas to San Benito de Palermo that circulated in the territories of New Spain, most of which were produced locally in the 18th and 19th centuries. While these devotional books can be used as a means of taking the measure of official holiness during the years of their publication, upon closer analysis this body of religious literature reveals the virtues and attributes of this Sicilian Saint that descended upon, among others, people of African descent. For this reason, the discussion surrounding his «skin color» constituted the principal obstacle against which this Negro Franciscan found himself struggling constantly. In the final section, the paper highlights the role of the Franciscans in New Spain during the colonial period in America as the community that, through the medium of the printing press, most strongly promoted the cult of this illustrious figure.
Full Text Available Introduction: Melanocytic lesions show great morphological diversity in their architecture and the cytomorphological appearance of their composite cells. Histological assessment of these melanocytic nevi constitutes a substantial proportion of a dermatopathologist’s daily workload. The aim of our study was to observe the histological spectrum and types of benign melanocytic nevi and melanoma and also to identify the unusal/atypical histological features in these melanocytic nevi. Results: Intradermal nevus was the most common benign melanocytic nevi comprising 11 (62.5% out of the total 13 cases. In ten cases lesions were located on head and neck region. Maximum number (60% of cases were seen between 30-40 years of age. Conclusion: Melanocytic lesions of the skin are of notorious challengefor the pathologist. Face was the most common site and intradermal nevus was the most common lesion in our study.
Capparelli, Ignacio; Fernandez, Martín; Saadia Otero, Marcela; Steimberg, Jimena; Brassesco, María; Campobasso, Ana; Palacios, Sandra; Caro, Fabian; Alberti, María Laura; Rabinovich, Roberto A; Paulin, Francisco
Interstitial lung disease (ILD) is associated with low exercise tolerance, dyspnea, and decreased health-related quality of life (HRQL). Idiopathic pulmonary fibrosis (IPF) is one of the most prevalent in the group. A specific version of the Saint George's questionnaire (SGRQ-I) has been developed to quantify the HRQL of IPF patients. However, this tool is not currently validated in the Spanish language. The objective was to translate into Spanish and validate the specific Saint George's Respiratory Questionnaire for idiopathic pulmonary fibrosis (SGRQ-I). The repeatability, internal consistency and construct validity of the SGRQ-I in Spanish were analyzed after a backtranslation process. In total, 23 outpatients with IPF completed the translated SGRQ-I twice, 7 days apart. Repeatability was studied, revealing good concordance in test-retest with an ICC (interclass correlation coefficient) of 0.96 (Ptotal value) (Ptotal score of the questionnaire showed good correlation with forced vital capacity FVC% (r=-0.44; P=.033), diffusing capacity of the lungs for carbon monoxide (DLCO%) (r=-0.55; P=.011), partial pressure of oxygen in arterial blood PaO2 (r=-0.44; P=.036), Medical Research Council Dyspnea scale (r=-0.65; P<.001), and number of steps taken in 24hours (r=-0.47; P=.024). The Spanish version of SGRQ-Ideveloped by our group shows good internal consistency, reproducibility and validity, so it can be used for the evaluation of quality of life (QOL) in IPF patients. Copyright © 2017 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.
Kelly, Patrick J; Stocking, Ruey; Gao, Dongya; Phillips, Nikol; Xu, Chuanling; Kaltenboeck, Bernhard; Wang, Chengming
Although antibodies to the feline immunodeficiency virus (FIV) have been detected by SNAP assay in cats from St. Kitts, there have been no molecular studies to further confirm the infection and determine the FIV subtypes present. Total nucleic acids were extracted from EDTA whole blood specimens from 35 cats, followed by quantitative fluorescence resonance energy transfer (FRET) PCR under a six-channel LightCycler 2.0 Instrument with Software version 4.1. Four of 11 stray cats (36 %) but none of 24 owned cats were FIV positive by real-time PCR. High-resolution melting curve analysis indicated that all four positive cats were infected with FIV subtype-B. This is the first molecular characterization of FIV subtypes on St. Kitts and the results confirm the high prevalence of FIV infection in stray cats on the island.
Appearance of New Vemurafenib-associated Melanocytic Nevi on Normal-appearing Skin: Case Series and a Review of Changing or New Pigmented Lesions in Patients with Metastatic Malignant Melanoma After Initiating Treatment with Vemurafenib
Cohen, Philip R.; Bedikian, Agop Y.; Kim, Kevin B.
Background: Vemurafenib, a selective BRAF inhibitor that has antineoplastic activity in patients with unresectable or metastatic malignant melanoma whose tumor harbors a BRAF V600E mutation, has multiple drug-associated cutaneous adverse effects. Purpose: To provide a detailed and comprehensive review of reported changing or new pigmented lesions in oncology patients who have been treated with vemurafenib. Methods: The new appearance of melanocytic nevi on normal-appearing skin after initiati...
Melanocytic lesions of the genital area are rare. They arise mainly in the vulva, although they can also occur less frequently in the perineum, mons pubis and male genitalia and represent 10-12% of pigmented lesions of White women. These pigmented lesions include melanocytic nevi, lentigines, melanocytic nevi with architectural disorder and atypia of melanocytes (dysplastic nevi) and melanomas with microscopic features similar to those seen elsewhere on the body. There is a small subset of benign nevi named atypical melanocytic nevi of the genital type (AMNGT) that occur in young women, with distinctive histologic features in some cases overlapping morphologically with those of melanoma. Thus, it is important to distinguish AMNGT from melanomas in terms of prognosis and treatment. We retrieved 58 cases of genital pigmented lesions diagnosed at our hospital from 1986 to 2008 to evaluate their clinicopathologic features with especial consideration to those cases with atypical features. Thirty-two cases (55%) were common nevi, 10 (17%) lentigines, 6 (10%) melanomas, 3 (5%) dysplastic nevi and 1 blue nevus. Six cases (10%) corresponded to AMNGT and were taken from women with a median age of 21 years. All cases showed symmetry, and the melanocytic proliferation was well demarcated at the lateral margins. The junctional component was very prominent and formed by round or fusiform nests with common retraction artifact and/or cellular dyshesion or as a single cell proliferation with mild (33%) to moderate (67%) cytologic atypia, focal pagetoid spread (17%) and a benign-appearing dermal component (83%) with maturation and dense eosinophilic fibrosis in the superficial dermis. Neither nuclear atypia of melanocytes in the superficial dermis nor dermal mitoses were observed. AMNGT were excised, and no recurrences were recorded in the follow up (median 10.5 years). Therefore, it seems that there is no evidence that AMNGT are precursors of dysplastic nevi or melanomas.
Gambichler, T; Senger, E; Rapp, S; Alamouti, D; Altmeyer, P; Hoffmann, K
Shave excision is an established surgical method for removing benign skin lesions for cosmetic and functional reasons. Usually superficial shave excision is performed with a common scalpel blade for the removal of papular nevi. However, there is little known about deep shave excision of macular melanocytic nevi with the razor blade technique. The present study was undertaken to evaluate the cosmetic outcome of deep shave excision of macular melanocytic nevi with the razor blade technique. Moreover, its potency for sufficient removal of these lesions was investigated. Within routine skin cancer screening 45 outpatients with a total of 77 macular melanocytic nevi were prospectively recruited. Deep shave excisions of these lesions were performed with a double-edged razor blade followed by chemical hemostasis. Histologically all specimens were processed and evaluated in a routine manner. After 6 months the physician and patients evaluated the shave sites for cosmetic outcome with a score graded from 1 to 4 (1 = excellent; 2 = good; 3 = moderate; 4 = poor). Histologically 88% (68 of 77) of the melanocytic lesions were described as completely excised and 60% (46 of 77) were diagnosed as atypical melanocytic nevi; 12% (9 of 77) of the nevi were incompletely excised on the depth. On average, the deep margin of the specimens (n = 77) was 0.5 mm (range 0-1.8 mm) and the lateral margin was 2 mm (range 0.3-8.2 mm). After 6 months 56 shave sites could be reassessed. We observed mild hypopigmentation in 52% (29 of 56), hyperpigmentation in 32% (18 of 56), and erythema in 23% (13 of 56). Recurrent nevi occurred in 13% (7 of 56). The evaluation of the cosmetic outcome by the patients (mean score 1.7) achieved better results than the evaluation by the physician (mean score 2.5). The cosmetic results showed no significant (P >.05) differences in various anatomic sites. Our data confirm that deep razor blade excision presents a highly useful and inexpensive method for the removal of
Evarts, Russell C.
The Saint Helens 7.5' quadrangle is situated in the Puget-Willamette Lowland approximately 35 km north Portland, Oregon. The lowland, which extends from Puget Sound into west-central Oregon, is a complex structural and topographic trough that lies between the Coast Range and the Cascade Range. Since late Eocene time, Cascade Range has been the locus of a discontinuously active volcanic arc associated with underthrusting of oceanic lithosphere beneath the North American continent along the Cascadia Subduction Zone. The Coast Range occupies the forearc position within the Cascadia arc-trench system and consists of a complex assemblage of Eocene to Miocene volcanic and marine sedimentary rocks. The Saint Helens quadrangle lies in the northern part of the Portland Basin, a roughly 2000-km2 topographic and structural depression. It is the northernmost of several sediment-filled structural basins that collectively constitute the Willamette Valley segment of the Puget-Willamette Lowland (Beeson and others, 1989; Swanson and others, 1993; Yeats and others, 1996). The rhomboidal basin is approximately 70 km long and 30 km wide, with its long dimension oriented northwest. The Columbia River flows west and north through the Portland Basin at an elevation near sea level and exits through a confined bedrock valley less than 2.5 km wide about 16 km north of Saint Helens. The flanks of the basin consist of Eocene through Miocene volcanic and sedimentary rocks that rise to elevations exceeding 2000 ft (610 m). Seismic-reflection profiles (L.M. Liberty, written commun., 2003) and lithologic logs of water wells (Swanson and others, 1993; Mabey and Madin, 1995) indicate that as much as 550 m of late Miocene and younger sediments have accumulated in the deepest part of the basin near Vancouver. Most of this basin-fill material was carried in from the east by the Columbia River but contributions from streams draining the adjacent highlands are locally important. The Portland Basin has
Möller, Inga; Murali, Rajmohan; Müller, Hansgeorg; Wiesner, Thomas; Jackett, Louise A; Scholz, Simone L; Cosgarea, Ioana; van de Nes, Johannes Ap; Sucker, Antje; Hillen, Uwe; Schilling, Bastian; Paschen, Annette; Kutzner, Heinz; Rütten, Arno; Böckers, Martin; Scolyer, Richard A; Schadendorf, Dirk; Griewank, Klaus G
Blue nevi are common melanocytic tumors arising in the dermal layer of the skin. Similar to uveal melanomas, blue nevi frequently harbor GNAQ and GNA11 mutations. Recently, recurrent CYSLTR2 and PLCB4 mutations were identified in uveal melanomas not harboring GNAQ or GNA11 mutations. All four genes (GNAQ, GNA11, CYSLTR2, and PLCB4) code for proteins involved in the same signaling pathway, which is activated by mutations in these genes. Given the related functional consequences of these mutations and the known genetic similarities between uveal melanoma and blue nevi, we analyzed a cohort of blue nevi to investigate whether CYSLTR2 and PLCB4 mutations occur in tumors lacking GNAQ or GNA11 mutations (as in uveal melanoma). A targeted next-generation sequencing assay covering known activating mutations in GNAQ, GNA11, CYSLTR2, PLCB4, KIT, NRAS, and BRAF was applied to 103 blue nevi. As previously reported, most blue nevi were found to harbor activating mutations in GNAQ (59%, n=61), followed by less frequent mutations in GNA11 (16%, n=17). Additionally, one BRAF (1%) and three NRAS (3%) mutations were detected. In three tumors (3%) harboring none of the aforementioned gene alterations, CYSLTR2 mutations were identified. All three CYSLTR2 mutations were the same c.386T>A, L129Q mutation previously identified in uveal melanoma that has been shown to lead to increased receptor activation and signaling. In summary, our study identifies CYSLTR2 L129Q alterations as a previously unrecognized activating mutation in blue nevi, occuring in a mutually exclusive fashion with known GNAQ and GNA11 mutations. Similar to GNAQ and GNA11 mutations, CYSLTR2 mutations, when present, are likely defining pathogenetic events in blue nevi.
Watt, Andrew J; Kotsis, Sandra V; Chung, Kevin C
Large congenital melanocytic nevi are cutaneous lesions regarded by many as premalignant; estimates of malignancy incidence range from 0 to 42 percent. Given the often complex and extensive nature of large congenital melanocytic nevi resection and reconstruction, the risk of malignant transformation is a crucial factor that surgeons and families must weigh when deciding whether or not to excise the lesion. The authors conducted a systematic analysis of data from the existing literature to critically evaluate the published studies and to establish a crude incidence rate for the risk of malignant melanoma transformation in large congenital melanocytic nevi. After a comprehensive literature search, they analyzed data from eight studies (containing a total of 432 large congenital melanocytic nevi patients) of sufficient scientific quality. Twelve patients (2.8 percent) in this sample developed cutaneous malignant melanoma during the reported follow-up periods. Using a subset of this data and comparing the incidence rates to those of the Surveillance, Epidemiology, and End Results population-based database using a standardized morbidity ratio, the authors found that the large congenital melanocytic nevi patients had an increased risk of melanoma (standardized morbidity ratio, 2599; 95 percent confidence interval, 844 to 6064) compared with the general population. Regarding treatment before developing melanoma in the 12 patients, 50 percent were observed before diagnosis, 17 percent had partial excision, 8.3 percent had dermabrasion, 8.3 percent had a chemical peel, and 17 percent did not have any treatment information. These combined data are clinically useful when consulting with the parents of children with large congenital melanocytic nevi and in the management of older patients with existing lesions. This study shows that there is a significantly increased risk of melanoma in large congenital melanocytic nevi patients. The data also reveal the need for a
Full Text Available The liturgical cult of Saint Florian in the Cracow Church was developing rapidly in medieval times. A few dozen years after his relics had been brought to Cracow , a native patron – Saint Stanislaus- became a saint. Since then the cult of a foreign and unknown martyr deteriorated. The revival of Saint Florian’s cult was possible under the influence of Zbigniew Oleśnicki, a bishop who appointed him as patron saint of the whole Polish Kingdom, thus making him equally important as Saint Adalbert, Saint Stanislaus and Saint Wacław. Since that time the liturgical cult of Saint Florian was of high significance, which can be certified by liturgical texts and formulas found in Cracow medieval breviaries. The analysis of their content leads to the conclusion that the older the breviaries, the fewer texts mentioning Saint Florian. The oldest breviaries contain only the liturgical collect referring to him. The newer ones are gradually enriched with the elements of choral liturgy and lessons originating from the legend about Saint Florian. Between the 15th and 16th centuries the liturgy in honor of Saint Florian culminates in the rhymed office.
Feldstein, Stephanie; Afshar, Maryam; Krakowski, Andrew C
"Natural home remedies" for nevi removal found on the Internet can be ineffective, or worse, dangerous. Children and teens, in particular, may be more likely to attempt self-treatment in order to avoid discussing their concerns with their parents. Here, the authors report a case of an adolescent who presented with a chemical burn after following an Internet-based protocol for nevi removal using apple cider vinegar.
Feldstein, Stephanie; Afshar, Maryam
“Natural home remedies” for nevi removal found on the Internet can be ineffective, or worse, dangerous. Children and teens, in particular, may be more likely to attempt self-treatment in order to avoid discussing their concerns with their parents. Here, the authors report a case of an adolescent who presented with a chemical burn after following an Internet-based protocol for nevi removal using apple cider vinegar. PMID:26155328
Green, Margaret C; Mitchum, Marsha D; Marquart, Jason D; Bingham, Jonathan L
Giant congenital melanocytic nevi (GCMN) are a rare type of melanocytic nevus that covers a large body surface, often with satellite nevi scattered on the rest of the skin. There are several complications associated with GCMN, including malignant melanoma and neurocutaneous melanosis. The management of GCMN is very complex because of the cosmetic appearance and the associated psychological distress, the risk of severe complications, and the need for long-term follow-up. We report a case of a 43-year-old active-duty female with a GCMN reporting new and symptomatic satellite lesions with atypical features on dermoscopy. Reprint & Copyright © 2014 Association of Military Surgeons of the U.S.
Sanger, Michael J.; Brincks, Erik L.; Phelps, Amy J.; Pak, Maria S.; Lyovkin, Antony N.
This paper, which is a result of the collaboration between the University of Northern Iowa (UNI) in Cedar Falls, Iowa, and Herzen State Pedagogical University of Russia in Saint Petersburg, compares the 7-12 chemistry courses in Iowa and Saint Petersburg and the chemistry teacher preparation programs at UNI and Herzen. Differences in the 7-12 chemistry courses include curriculum design (spiral versus layer cake), students' extracurricular activities, and access to technology in the classroom. Differences in the chemistry teacher preparation programs include the number of methods and chemistry content courses required, the number of chemistry teaching majors, the proportion of teaching majors enrolled in the different natural science programs, and the typical minors and endorsements received by these majors. Although we noted many differences in chemistry instruction between Iowa and Saint Petersburg, the secondary and college instructors still face many similar issues, which include overcoming student chemophobia, improving students' algorithmic and problem-solving skills, improving students' conceptual understanding at the particulate level, and dealing with shortages in qualified secondary science teachers.
Appearance of New Vemurafenib-associated Melanocytic Nevi on Normal-appearing Skin: Case Series and a Review of Changing or New Pigmented Lesions in Patients with Metastatic Malignant Melanoma After Initiating Treatment with Vemurafenib.
Cohen, Philip R; Bedikian, Agop Y; Kim, Kevin B
Vemurafenib, a selective BRAF inhibitor that has antineoplastic activity in patients with unresectable or metastatic malignant melanoma whose tumor harbors a BRAF V600E mutation, has multiple drug-associated cutaneous adverse effects. To provide a detailed and comprehensive review of reported changing or new pigmented lesions in oncology patients who have been treated with vemurafenib. The new appearance of melanocytic nevi on normal-appearing skin after initiating treatment with vemurafenib is described in two men with metastatic malignant melanoma whose tumors demonstrated a BRAF V600E mutation. Using the PubMed database, an extensive literature search was performed for the following topics: vermurafenib, nevus, nevi, melanoma, pigmented lesion, cutaneous, adverse effect, side effect. The results of the search were used to secure all reports of new or changing pigmented lesions after initiating treatment with vemurafenib. Vemurafenib is associated with both changes in existing pigmented lesions (including involution, alteration of color and size, and progression to melanoma) and the onset of new melanocytic lesions-nevi (in 5 patients) and primary melanomas (in 2 patients). Visual examination, dermoscopic evaluation, and reflectance confocal microscopy have been used to document the changes in existing or new melanocytic lesions subsequent to initiating treatment with vermurafenib. Histopathology analysis has shown these lesions to usually be either dysplastic nevi or new primary melanomas. Vemurafenib-treated patients can develop new pigmented lesions (such as nevi) and/or morphological changes in their existing melanocytic lesions (such as involution, increase in size, or alternation of color). In addition, they can develop new primary malignant melanomas that either occur de novo on normal-appearing skin or develop in pre-existing melanocytic lesions. Therefore, total body skin examination should be considered prior to initiating treatment with vemurafenib
Full Text Available The idea of an essential connection between the quality of a song and the sincerity of the emotion it expresses ("I sing because I love" is a topos used in various ways by troubadours, one which lent itself naturally to discussion of their relationship to audiences and to other poets. The topos transferred across to the thirteenth-century biographies (vidas found alongside the songs in numerous manuscripts, as in the arresting claim, made in the vida about Daude de Pradas, that his songs "did not spring from love and therefore did not find favour with audiences." Elsewhere, however, the biographies give a different account of inauthenticity, as the edge which allows troubadours to exercise control over their social environment; significantly, this version of the topos appears in the vida for Uc de Saint Circ, who is believed to be the main author of the corpus. In these contrasting accounts of poetic inauthenticity, we can see the biographies wrestling with questions of control and definition of the cultural capital of troubadour lyric: patron and poet, cleric and lay. The thirteenth century saw authors and their audiences increasingly asserting the lasting cultural value of vernacular literature in general, and (through its association with troubadour production Occitan in particular. Accordingly, these texts reflect the poets' engagement with the court audiences for whom they were writing, at the same time as they look ahead to the enduring record of posterity.
Ivoni Richter Reimer
The article presents and analyzes fragments of the story of Saint Praxedes, leader of a domestic church in 1st century in Rome, and their resignification over the centuries, mainly under Pope Paschal I (9th century...
Lister, Allyson L; Pocock, Matthew; Taschuk, Morgan; Wipat, Anil
Saint is a web application which provides a lightweight annotation integration environment for quantitative biological models. The system enables modellers to rapidly mark up models with biological information derived from a range of data sources. Saint is freely available for use on the web at http://www.cisban.ac.uk/saint. The web application is implemented in Google Web Toolkit and Tomcat, with all major browsers supported. The Java source code is freely available for download at http://saint-annotate.sourceforge.net. The Saint web server requires an installation of libSBML and has been tested on Linux (32-bit Ubuntu 8.10 and 9.04).
Zhang, Guohong; Li, Gang
Distinguishing melanoma from dysplastic nevi can be challenging. To assess which putative molecular biomarkers can be optimally combined to aid in the clinical diagnosis of melanoma from dysplastic nevi...
Full Text Available This Article is an attempt to shed light on a few texts of the acts of the Apostles and of the epistles which are viewed as sources documenting the life and activity of Saint Paul. The author attempts to settle a number of questions regarding the authenticity of sources illustrating the life of Saint Paul. Similar questions are often raised by those who write and publish guides and textbooks for the teaching of the Pauline corpus. The author agrees with the overwhelming positive judgment of the academic world regarding the authenticity of the pastoral epistles, but at the same time he notes a number of objections to their authenticity proposed by the same forum: inconsistencies within the vocabulary of the texts themselves, their linguistic style, and their theological argumentation. The author concludes that these objections are inconclusive and the features enumerated by those who object constitute in reality only minor exceptions, inconsequential when taking into account the entire Pauline corpus. The author also examines the authenticity and historical accuracy of the account of the life of Saint Paul as given in the Acts of the Apostles. A few Biblicists claim that the account in Acts is merely legendary and is to be regarded as a type of early Christian folklore. The author disagrees with this opinion, backing up his position with the evidence that both the Acts of the Apostles and the Pastoral Epistles agree in historical detail and background. The author concludes with a further consideration regarding the correct method guiding biblical research on Saint Paul. He opines that such research must view the biblical texts in a correct historical perspective
Journal Article 3. DATES COVERED (From – To) June 2014 – December 2014 4. TITLE AND SUBTITLE Saint Louis Center for Sustainment of Trauma and...Readiness Skills: A Collaborative Air Force-Civilian Trauma Skills Training Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...in support of these campaigns have had to maintain a high degree of clinical skill to effectively render care to wounded combatants, a necessity
D. E. Soboleva
Full Text Available The purpose of the study is the assessment of iodine status and effectiveness of iodine prophylaxis among the population of reproductive age. In this regard, we examined 200 individuals from 18 up to 44 years old living in Saint Petersburg for more than 3 years permanently. Most of the examined individuals had mild iodine deficiency, less than half of people of reproductive age (46 % used iodized salt at home. Goiter was found by palpation in 8 % of participants. More than half of the surveyed individuals are women of reproductive age who are at risk for the development of iodine deficiency disorders. Our data reflect an unfavorable situation in fight against iodine deficiency disorders in Saint Petersburg. Probably, the voluntary model of using iodized salt as the prevention of iodine deficiency in the Russian Federation is not effective enough.
Full Text Available Saint John Chrysostom is one of the most remarkable personalities of the forth century of Christianity, also known as “the golden century”. His missionary and writing activity left a peerless treasure to the Church. His theological compositions enriched the cultural heritage with an innovative and clear way of approaching the topic of Christian ministry. The following study will present the Saint’s vision on the mission of the Church and the profile of the “soul’s shepherd”, nobody else but the priest, as he describes it in his treaty “On Priesthood”. We will discuss this subject starting from the statements used by the Saint to justify his refusal of becoming a priest. Therefore, we will analyze the moral and missionary profile of the priest, the cultural and social circumstances in which he has to perform, and all the difficulties he must face. We will reach the conclusion that the mission of the priests during the first centuries is not any different from the one of today, so the teaching given by the Saint is eternally valid.
Desrosiers, Alethea; Blokhina, Elena; Krupitsky, Evgeny; Zvartau, Edwin; Schottenfeld, Richard; Chawarski, Marek
The Russian Federation is experiencing a very high rate of HIV infection among people who inject drugs (PWID). However, few studies have explored characteristics of people with co-occurring opioid use disorders and HIV, including psychiatric symptom presentations and how these symptoms might relate to quality of life. The current study therefore explored a.) differences in baseline psychiatric symptoms among HIV+ and HIV- individuals with opioid use disorder seeking naltrexone treatment at two treatment centers in Saint Petersburg, Russia and b.) associations between psychiatric symptom constellations and quality of life. Participants were 328 adults enrolling in a randomized clinical trial evaluating outpatient treatments combining naltrexone with different drug counseling models. Psychiatric symptoms and quality of life were assessed using the Brief Symptom Inventory and The World Health Organization Quality of Life-BREF, respectively. Approximately 60% of participants were HIV+. Those who were HIV+ scored significantly higher on BSI anxiety, depression, psychoticism, somatization, paranoid ideation, phobic anxiety, obsessive-compulsive, and GSI indexes (all p<0.05) than those HIV-. A K-means cluster analysis identified three distinct psychiatric symptom profiles; the proportion of HIV+ was significantly greater and quality of life indicators were significantly lower in the cluster with the highest psychiatric symptom levels. Higher levels of psychiatric symptoms and lower quality of life indicators among HIV+ (compared to HIV-) individuals injecting drugs support the potential importance of combining interventions that target improving psychiatric symptoms with drug treatment, particularly for HIV+ patients. Copyright © 2017 Elsevier B.V. All rights reserved.
Bogolyubova, Olga; Skochilov, Roman; Smykalo, Lyubov
Exposure to childhood victimization and abuse has been shown to affect HIV risk in adult populations. In Russia, the existence of child abuse was largely unrecognized until 1990s and its behavioral consequences remain understudied. Our goal was to assess childhood victimization and HIV risk behavior among young adults in Saint-Petersburg, Russia: 743 students from 15 local universities were surveyed. Unprotected sexual intercourse was the most common type of HIV risk behavior: study participants reported no condom use at last intercourse (65.17%), inconsistent condom use (58.43%) and 30.81% never used condoms in the past 3 months. Childhood sexual victimization was significantly associated with unprotected sex at last intercourse and with inconsistent condom use in the past 3 months. Young adults in Russia are vulnerable to HIV epidemic due to the pervasiveness of unprotected sexual intercourse, and childhood sexual victimization is associated with risky sexual behavior in this population. Efforts to combat HIV epidemic in Russia must include programming for the prevention of childhood sexual abuse and the development of services for the survivors of childhood victimization.
Roberts, Evan; Warren, John Robert
Concern with childhood nutrition prompted numerous surveys of children's growth in the United States after 1870. The Children's Bureau's 1918 "Weighing and Measuring Test" measured two million children to produce the first official American growth norms. Individual data for 14,000 children survives from the Saint Paul, Minnesota survey whose stature closely approximated national norms. As well as anthropometry the survey recorded exact ages, street address and full name. These variables allow linkage to the 1920 census to obtain demographic and socioeconomic information. We matched 72% of children to census families creating a sample of nearly 10,000 children. Children in the entire survey (linked set) averaged 0.74 (0.72) standard deviations below modern WHO height-for-age standards, and 0.48 (0.46) standard deviations below modern weight-for-age norms. Sibship size strongly influenced height-for-age, and had weaker influence on weight-for-age. Each additional child six or underreduced height-for-age scores by 0.07 standard deviations (95% CI: -0.03, 0.11). Teenage siblings had little effect on height-forage. Social class effects were substantial. Children of laborers averaged half a standard deviation shorter than children of professionals. Family structure and socio-economic status had compounding impacts on children's stature.
Ainouche, Abdelkader; Bétermier, Mireille; Chandler, Mick; Cordaux, Richard; Cristofari, Gaël; Deragon, Jean-Marc; Lesage, Pascale; Panaud, Olivier; Quesneville, Hadi; Vaury, Chantal; Vieira, Cristina; Vitte, Clémentine
An international conference on Transposable Elements (TEs) was held 21-24 April 2012 in Saint Malo, France. Organized by the French Transposition Community (GDR Elements Génétiques Mobiles et Génomes, CNRS) and the French Society of Genetics (SFG), the conference's goal was to bring together researchers from around the world who study transposition in diverse organisms using multiple experimental approaches. The meeting drew more than 217 attendees and most contributed through poster presentations (117), invited talks and short talks selected from poster abstracts (48 in total). The talks were organized into four scientific sessions, focused on: impact of TEs on genomes, control of transposition, evolution of TEs and mechanisms of transposition. Here, we present highlights from the talks given during the platform sessions. The conference was sponsored by Alliance pour les sciences de la vie et de la santé (Aviesan), Centre national de la recherche scientifique (CNRS), Institut national de la santé et de la recherche médicale (INSERM), Institut de recherche pour le développement (IRD), Institut national de la recherche agronomique (INRA), Université de Perpignan, Université de Rennes 1, Région Bretagne and Mobile DNA. CHAIR OF THE ORGANIZATION COMMITTEE: Jean-Marc Deragon ORGANIZERS: Abdelkader Ainouche, Mireille Bétermier, Mick Chandler, Richard Cordaux, Gaël Cristofari, Jean-Marc Deragon, Pascale Lesage, Didier Mazel, Olivier Panaud, Hadi Quesneville, Chantal Vaury, Cristina Vieira and Clémentine Vitte.
Adams, Annmarie; Poutanen, Mary Anne
This paper explores the architecture of the Mount Sinai Sanatorium in Sainte-Agathe-des-Monts (Qc) to disentangle the role of religion in the treatment of tuberculosis. In particular, we analyze the design of Mount Sinai, the jewel in the crown of Jewish philanthropy in Montreal, in relation to that of the nearby Laurentian Sanatorium. While Mount Sinai offered free treatment to the poor in a stunning, Art Deco building of 1930, the Protestant hospital had by then served paying patients for more than two decades in a purposefully home-like, Tudor-revival setting. Using architectural historian Bernard Herman's concept of embedded landscapes, we show how the two hospitals differed in terms of their relationship to site, access, and, most importantly, to city, knowledge, and community. Architects Scopes & Feustmann, who designed the Laurentian hospital, operated an office at Saranac Lake, New York, America's premier destination for consumptives. The qualifications of Mount Sinai architects Spence & Goodman, however, derived from their experience with Jewish institutions in Montreal. Following Herman's approach to architecture through movement and context, how did notions of medical therapy and Judaism intersect in the plans of Mount Sinai?
Casas, Paula; Isarowong, Nucha
Physicians affiliated with small community hospitals face numerous barriers to using developmentally oriented best practices in primary care with young children. Saint Anthony Hospital's Developmental Support Project model promotes improved developmental outcomes for children through two complementary strands of services: (a) training and…
R Clive Landis; Kelly Carmichael-Simmons; Hambleton, Ian R; Anton Best
Objective Since 2009, seven countries in the Organization of Eastern Caribbean States (OECS), Antigua & Barbuda, Dominica, Grenada, Montserrat, St. Kitts & Nevis, Saint Lucia, and St. Vincent & the Grenadines, have been utilizing a laboratory referral service for HIV-1 viral load (VL) offered by The Ladymeade Reference Unit (LRU) Laboratory, Barbados. The objective of this study was to evaluate 5 year VL trends in the six larger OECS countries participating in this regional referral service. ...
Fabricia Hallack Loures
Full Text Available In a period of eight years, nevic lesions were diagnosed in 81 cases. Fibroadnexal hamartoma (FH occurred in 53 animals (65.4%, and it was clinically characterized by firm nodules located mainly on the limbs and digits. No sexual predisposition was present. Mongrels, Boxers and Cocker Spaniels were the breeds most affected by FH. The average age at which lesions appeared was 6.3 years. The collagenous nevi was the second most prevalent lesion, occurring in 18 dogs (22.2%. The lesions were usually single, alopecic and hyperpigmented. The main affected places were the dorso and limbs. The average age at which lesions appeared was 4.7 years. Mongrels, Rottweilers and Labradors were the breeds most affected by the collagenous nevi. Nodular dermatofibrosis was diagnosed in one dog. In this dog, multiple collagenous nevi were present alongside unilateral papillary renal cystadenoma. Sebaceous, follicule-apocrine and fibrolipomatous nevi were less frequently found (10 cases - 12.3%.As lesões névicas foram diagnosticadas em 81 casos, em um período de oito anos. O Hamartoma fibroanexial (HF ocorreu em 53 animais (65,43% e caracterizou-se clinicamente por lesões nodulares, geralmente firmes, localizadas predominantemente nos membros e dígitos. Não houve predileção sexual. Os animais mestiços e os das raças Boxer e Cocker Spaniel foram os mais acometidos pelo HF. A idade média de aparecimento das lesões foi de 6,3 anos. O nevo colágeno foi a segunda lesão mais prevalente, ocorrendo em 18 cães (22,2%. As lesões foram, em geral, únicas, alopécicas e hiperpigmentadas, localizadas em sua maioria no tronco, no dorso e nos membros. A idade média de aparecimento das lesões foi de 4,7 anos. Os animais mestiços e os das raças Rottweiler e Labrador Retriever foram os mais acometidos. Em um dos cães, diagnosticou-se dermatofibrose nodular, onde foram observados múltiplos nevos colágenos em associação com cistadenoma renal papilar unilateral
Garambois, P. A.; Brisset, P.; Monnier, J.; Roux, H.
Profusion of satellites are providing increasingly accurate measurements of continental water cyle, and water bodies variations while in situ observability is declining. The future Surface Water and Ocean Topography (SWOT) mission will provide maps of river surface elevations widths and slopes with an almost global coverage and temporal revisits. This will offer the possibility to address a larger variety of inverse problems in surface hydrology. Data assimilation techniques, that are broadly used in several scientific fields, aim to optimally combine models, system observations and prior information. Variational assimilation consists in iterative minimization of a discrepency measure between model outputs and observations, here for retrieving boundary conditions and parameters of a 1D Saint Venant model. Nevertheless, inferring river discharge and hydraulic parameters thanks to the observation of river surface is not straightforward. This is particularly true in the case of sparse and uncertain observations of flow state variables since they are governed by nonlinear physical processes. This paper investigates the identifiability of hydraulic controls given sparse and uncertain satellite observations of a river. The identifiability of river discharge alone and with roughness is tested for several spatio temporal patterns of river observations, including SWOT like observations. A new 1D Shallow water model with variational data assimilation, within the DassFlow chain is presented as well as postprocessing and observation operator dedicated to the future SWOT and SWOT simulator data. In view to decrease inverse problem dimensionality discharge is represented in a reduced basis. Moreover we introduce an original and reduced parametrization of the flow resistance that can account for various flow regimes along with a cross section design dedicated to remote sensing. We show which discharge temporal frequencies can be identified w.r.t observation ones and at which
Kuznetsov S. V.
Full Text Available This article presents a modern interpretation of the concept of ‘geoeconomic situation’ as applied to one of the most important centers of the Baltic region — the St. Petersburg agglomeration. The coastal location of the agglomeration and close connections with the Leningrad region make it possible to consider the Saint Petersburg coastal region (Baltic Area as a whole. The article sets out not only to verify, confirm, and explain the features of the geoeconomic position of the coastal region, but also to describe the contiguous geoeconomic space. The position of the St. Petersburg coastal region is of crucial importance for ensuring a steady growth of regional economy, the propagation of industrialization impulses, and modernization in the heart of Russian Northwestern macroregion. At the same time, the specific features of the region’s geoeconomic position magnify the ‘inherited’ ad acquired effects of focal industrialization and space polarization, which creates additional prerequisites for the inversion of the Russian economic space — ‘Russia of the physical space’ and ‘the economic space of Russia’. The study uses traditional methodology of economic geography (the territorial, cluster, and spatial approaches and the geoeconomic approach developed by the authors. The article also addresses recent findings in regional economy and spatial studies. It is aimed at the development of the geoeconomic paradigm in the framework of social geography and that of spatial science. An analysis of the geoeconomic position and the developing spatial relations can be of interest for researchers of geographic clusters, agglomerations, and such cross-border forms of cooperation, as growth triangles, for example.
Emmanuel James P. Pattaguan
Full Text Available This study was meant to present an evaluation of the delivery of the University of Saint Louis’ Foreign Language Program-Mandarin Chinese. Using descriptive research design, coupled with focus group discussion with the students in total enumeration, data along the different aspects of the teaching and learning of Mandarin Chinese, was ascertained using a developed and validated questionnaire. The student-respondents have evaluated the following areas: 1.Objectives of the Lesson/Course 2 Lesson Strategies 3 Lesson Assessments 4 Student Engagement 5 Learning Resources and Environment 5 Classroom Management 6 Outcomes. Moreover, the grades of the students along two major assessments-oral and written were also looked into to validate the perceptions of students along outcomes. In addition, a structured interview with the teachers was also conducted to provide further information. Looking within, data gathered and analyzed reveals that the University’s Foreign Language Program with the offering of Mandarin Chinese is generally very satisfactory along all areas evaluated. The oral and written examination results as reflected in the grades of the students show that the students have gained adequate skills in both oral and written Mandarin Chinese, although among all areas, it’s the written Mandarin that got the lowest mean rating among all items under “outcomes”. From the foregoing, realizations have been made that while the evaluation is generally very satisfactory using the scale, there is a need for the University to look into specific items under the major areas by way of designing intervention programs to further improve the delivery of the current foreign language program to its students. Moreover, an in-depth study of the same can be expanded to other classes delivered by Filipino professors.
Dear Colleagues, 1st International School and Conference "Saint Petersburg OPEN 2014" on Optoelectronics, Photonics, Engineering and Nanostructures was held on March 25 - 27, 2014 at St. Petersburg Academic University - Nanotechnology Research and Education Centre of the Russian Academy of Sciences. The School and Conference included a series of invited talks given by leading professors with the aim to introduce young scientists with actual problems and major advances in physics and technology. The keynote speakers were: Mikhail Glazov (Ioffe Physico-Technical Institute RAS, Russia) Vladimir Dubrovskii (Saint Petersburg Academic University RAS, Russia) Alexey Kavokin (University of Southampton, United Kingdom and St. Petersburg State University, Russia) Vladimir Korenev (Ioffe Physico-Technical Institute RAS, Russia) Sergey Kukushkin (Institute of Problems of Mechanical Engineering RAS, Russia) Nikita Pikhtin (Ioffe Physico-Technical Institute RAS, Russia and "Elfolum" Ltd., Russia) Dmitry Firsov (Saint Petersburg State Polytechnical University, Russia) During the poster session all undergraduate and graduate students attending the conference presented their works. Sufficiently large number of participants with more than 160 student attendees from all over the world allowed the Conference to provide a fertile ground for the fruitful discussions between the young scientists as well as to become a perfect platform for the valuable discussions between student authors and highly experienced scientists. The best student papers, which were selected by the Program Committee and by the invited speakers basing on the theses and their poster presentation, were awarded with diplomas of the conference - see the photos. This year's School and Conference is supported by SPIE (The International Society for Optics and Photonics), OSA (The Optical Society), St. Petersburg State Polytechnical University and by Skolkovo Foundation. It is a continuation of the annual schools and
Full Text Available This article offers an anthropological analysis of a conflict over the use of a set of 'healing chains' and other focal objects kept in the Orthodox Christian monastery of Saints Kosmas and Damian in Kuklen, Bulgaria. In a nutshell, the conflict captures the leading religious imageries propagated by the custodians of the monastery on the one hand, and the spiritual leaders of a new religious movement, so-called Deunovians, on the other. The analysis helps situate some of the significant changes currently affecting the religious culture of Orthodox Christians in Bulgaria within a broader social and cultural context.
Nienhaus, Albert; Gariepy, Paul-Kenneth; Trouve, Catherine; Lhaumet, Christiane; Toureau, Jean; Peters, Claudia
Healthcare workers (HCWs) are exposed to Mycobacterium tuberculosis (MTB) and therefore are screened for tuberculosis (TB). Results of TB screenings with the Interferon-γ Release Assay (IGRA) in a French psychiatric hospital without a TB ward are described. At the Sainte-Anne Hospital, a referral centre for psychiatric patients throughout the municipal region of Paris, IGRA screening is performed during pre-employment and general health examination or after potential contact to MTB. The QuantiFERON Gold in tube (QFT) is used and data on TB history are assessed in a standardized manner. Between August 2008 und August 2013 in total 1.192 HCWs were tested and the QFT was positive in 265 (22.2%). Probability of a positive QFT increased with age. A second QFT was performed in 144 HCWs with a positive QFT and 53 (36.8%) HCWs had a reversion. With a positive QFT close to the cut-off (e.g. 0.35-0.7 IU/ml) the odds ratio for a reversion was 4.6 compared to an INF-γ concentration of ≥3.0 IU/ml. Probability of reversion was not influenced by preventive chemotherapy, which was completed by 28 (19.4%) HCWs with a positive QFT. No active TB was detected. Prevalence of positive IGRA is high in French HCWs as is the number of reversions in IGRA. Reversion rate is particularly high around the cut-off of the IGRA. A borderline zone will therefore reduce the influence of test variability.
Mentrikoski, Mark J; Ma, Linglei; Pryor, Jennifer G; McMahon, Loralee A; Yang, Qi; Spaulding, Betsy O; Scott, Glynis A; Wang, Hanlin L; Xu, Haodong
Depending on the Breslow depth of the primary melanoma, sentinel lymph node biopsy is considered as standard of care for the staging of cutaneous melanoma, and is one of the most important prognostic factors. The histologic analysis of these specimens becomes difficult to interpret when benign intranodal nevic cells mimic metastases. Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP3), also known as K homology domain-containing protein overexpressed in cancer or L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and has been shown to have diagnostic utility in distinguishing cutaneous melanoma from benign nevi. In this study, 43 sentinel lymph node biopsy specimens, including 13 with benign intranodal nevi and 30 with metastatic melanoma (two cases containing both benign nevi and metastatic melanoma), from 41 patients were immunohistochemically analyzed with a monoclonal antibody against IMP3. None of the benign intranodal nevi expressed IMP3, whereas 21 out of 30 (70%) of the lymph nodes containing metastatic melanoma did. It seems that IMP3 is helpful in distinguishing benign intranodal nevi from metastatic melanoma in sentinel lymph node biopsy specimens, and could be a valuable diagnostic adjunct in sentinel lymph node biopsy assessment in which questions arise as to the malignancy of the melanocytes present.
Full Text Available Leptospirosis is an important waterborne zoonotic disease caused by pathogenic Leptospira. The pathogen is maintained in a population due to chronic colonization and shedding from renal tubules of domestic and wild animals. Humans and other animals become infected when they come in contact with urine from infected animals, either directly or through urine-contaminated surface water. In this study, we screened environmental water on the island of St. Kitts by using a TaqMan based real time quantitative polymerase chain reaction (qPCR targeting a pathogen specific leptospiral gene, lipl32. Our results indicate that around one-fifth of tested water sources have detectable leptospiral DNA.
Beldekos, Dimitris; Karamanou, Marianna; Poulakou-Rebelakou, Effie; Ploumpidis, Dimitris; Androutsos, George
The iconography of the doctor saints Cosmas and Damian and the artistic representations of their miracles are important sources for the history of medicine. Within the sphere of physician-saints, Cosmas and Damian have the greatest number of iconographic depictions in Byzantine and Post-Byzantine art. In most of their representations, they wear long robes as a sort of professional mantles and carry surgical instruments and boxes indicating their status as doctors. The progress of Byzantine surgery could be attested by these objects, some of them mentioned in collections of miracle stories and documented in medical sources.
Sand, Michael; Skrygan, Marina; Sand, Daniel; Georgas, Dimitrios; Gambichler, Thilo; Hahn, Stephan A; Altmeyer, Peter; Bechara, Falk G
Perturbations in microRNA (miRNA) expression profiles have been reported for cutaneous malignant melanoma (CMM) predominantly when examined in cell lines. Despite the rapidly growing number of newly discovered human miRNA sequences, the availability of up-to-date miRNA expression profiles for clinical samples of primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM), and benign melanocytic nevi (BMN) is limited. Specimens excised from the center of tumors (lesional) from patients with PCMM (n=9), CMMM (n=4), or BMN (n=8) were obtained during surgery. An exploratory microarray analysis was performed by miRNA expression profiling based on Agilent platform screening for 1205 human miRNAs. The results from the microarray analysis were validated by TaqMan quantitative real-time polymerase chain reaction. In addition to several miRNAs previously known to be associated with CMM, 19 unidentified miRNA candidates were found to be dysregulated in CMM patient samples. Among the 19 novel miRNA candidates, the genes hsa-miR-22, hsa-miR-130b, hsa-miR-146b-5p, hsa-miR-223, hsa-miR-301a, hsa-miR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260, hsa-miR-1274a, hsa-miR-1274b, hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR-4286 were upregulated, and the genes hsa-miR-24-1*, hsa-miR-26a, hsa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated. The results of this study partially confirm previous CMM miRNA profiling studies identifying miRNAs that are dysregulated in CMM. However, we report several novel miRNA candidates in CMM tumors; these miRNA sequences require further validation and functional analysis to evaluate whether they play a role in the pathogenesis of CMM.
Yakovleva, O. S.; Pekov, I. V.; Horváth, L.; Bryzgalov, I. A.; Yapaskurt, V. O.; Guseva, E. V.
High-alumina fenites in the Mont Saint-Hilaire alkaline complex, Québec, Canada, form bodies at the contact of peralkaline nepheline syenite. Fenites are subdivided into four types: corundum-spessartine-biotite-feldspar, muscovite-corundum-hercynite-biotite-feldspar, carbonated muscovite-biotite-hercynite-feldspar, and spessartine-hercynite-feldspar. Accessory minerals of the ilmenite-pyrophanite series, columbites, zircon, thorite, pyrrhotite, Fe, Mn, Mg, Ca, Ba, and REE carbonates, uedaite-(Ce), etc. are identified. Three stages are suggested in the formation of these rocks. In mineralogy and geochemistry, the Mont Saint-Hilaire high-alumina fenites are similar to Al-rich fenites replacing xenoliths in the Khibiny alkaline complex, Russia. In both cases, fenites are related to peralkaline rocks and replace high-alumina protoliths: granite at Mont Saint-Hilaire and metapelites in the Khibiny Mountains. These fenites are regarded as a specific type of fenites with rock-forming Mg-depleted hercynite.
Menzies, Scott W; Stevenson, Mary L; Altamura, Davide; Byth, Karen
To determine whether certain patient demographics are associated with poorer specificity for the diagnosis of melanoma in nevi undergoing short-term sequential digital dermoscopic imaging. Retrospective cohort study performed from April 1, 1998, through May 31, 2007. Sydney Melanoma Diagnostic Centre, a tertiary referral institution. A total of 2497 benign melanocytic lesions in 1765 patients undergoing short-term sequential digital dermoscopic imaging during 2.5 to 4.5 months (42.3% male; mean [SD] age, 40  years; age range, 1-86 years). Proportion of changed nevi as a function of age, sex, lesion diameter, and anatomical site. The only variable significantly associated with nevus change was age group (P = .002). When compared with the middle-aged (aged 36-50 years) group, the odds of change were significantly increased in the child and adolescent (aged 0-18 years: odds ratio, 2.60; 95% confidence interval, 1.30-5.22), young adult (aged 19-35 years: 1.50; 1.04-2.17), and elderly (> 65 years old: 2.04; 1.04-3.99) age groups. Within the changed benign lesions, a significant association was observed between histologic subtype and age group (P = .01). The proportion of changed lesions of the banal nevi type decreased and the proportion of the dysplastic nevi type increased with age. In the elderly group, 75.9% of changed lesions were of the dysplastic nevi type compared with 35.7% in the youngest group. A poorer specificity is observed for the diagnosis of melanoma for nevi undergoing short-term sequential digital dermoscopic imaging in children and adolescents (75.7%) and elderly patients (77.9%) compared with other patients (84.6%).
Cotton, Michelle M.; Bruhn, Ronald L.; Sauber, Jeanne; Burgess, Evan; Forster, Richard R.
The Saint Elias Mountains in southern Alaska are located at a structural syntaxis where the coastal thrust and fold belt of the Fairweather plate boundary intersects thrust faults and folds generated by collision of the Yakutat Terrane. The axial trace of this syntaxis extends southeastward out of the Saint Elias Mountains and beneath Malaspina Glacier where it is hidden from view and cannot be mapped using conventional methods. Here we examine the surface morphology and flow patterns of Malaspina Glacier to infer characteristics of the bedrock topography and organization of the syntaxis. Faults and folds beneath the eastern part of the glacier trend northwest and reflect dextral transpression near the terminus of the Fairweather fault system. Those beneath the western part of the glacier trend northeast and accommodate folding and thrust faulting during collision and accretion of the Yakutat Terrane. Mapping the location and geometry of the structural syntaxis provides important constraints on spatial variations in seismicity, fault kinematics, and crustal shortening beneath Malaspina Glacier, as well as the position of the collisional deformation front within the Yakutat Terrane. We also speculate that the geometrical complexity of intersecting faults within the syntaxis formed a barrier to rupture propagation during two regional Mw 8.1earthquakes in September 1899.
Fernández-Nieto, E D; Narbona-Reina, G; Zabsonré, J D
In this work we present a deduction of the Saint-Venant-Exner model through an asymptotic analysis of the Navier-Stokes equations. A multi-scale analysis is performed in order to take into account that the velocity of the sediment layer is smaller than the one of the fluid layer. This leads us to consider a shallow water type system for the fluid layer and a lubrication Reynolds equation for the sediment one. This deduction provides some improvements with respect to the classical Saint-Venant-Exner model: (i) the deduced model has an associated energy. Moreover, it allows us to explain why classical models do not have an associated energy and how to modify them in order to recover a model with this property. (ii) The model incorporates naturally a necessary modification that must be taken into account in order to be applied to arbitrarily sloping beds. Furthermore, we show that this modification is different of the ones considered classically, and that it coincides with a classical one only if the solution ha...
Ferreira, Leticia; Jham, Bruno; Assi, Rouba; Readinger, Allison; Kessler, Harvey P
The purpose of this study was to evaluate the clinical and histopathologic features of oral melanocytic nevi (OMN). One hundred cases of OMN were retrieved from the files of two oral pathology services, and the data were analyzed with regard to histologic type and clinical features. Intramucosal nevus was the most common type (61%), followed by common blue nevus (23%), compound nevus (7%), and junctional nevus (3%). Combined nevus and cellular blue nevus were rare (2% each). The hard palate was the most commonly affected site (33%), followed by the buccal mucosa (18%), vermilion border of the lip (18%), and gingiva (15%). An interesting case of intramucosal nevus with lipomatosus-like changes and neurotization and two cases of oral dysplastic nevus are also reported. Intramucosal and common blue nevi are the most common types of OMN. Dysplastic nevus, which is recognized as a marker for melanoma in the skin, can rarely involve the oral cavity. Accordingly, dentists, especially oral and maxillofacial pathologists, should become familiar with the clinical and histopathologic features of this entity. Copyright © 2015 Elsevier Inc. All rights reserved.
Jeanne-Nicole Mellon Saint-Laurent
Full Text Available This article describes The Gateway to the Syriac Saints, a database project developed by the Syriac Reference Portal (www.syriaca.org. It is a research tool for the study of Syriac saints and hagiographic texts. The Gateway to the Syriac Saints is a two-volume database: 1 Qadishe and 2 Bibliotheca Hagiographica Syriaca Electronica (BHSE. Hagiography, the lives of the saints, is a multiform genre. It contains elements of myth, history, biblical exegesis, romance, and theology. The production of saints’ lives blossomed in late antiquity alongside the growth of the cult of the saints. Scholars have attended to hagiographic traditions in Greek and Latin, but many scholars have yet to discover the richness of Syriac hagiographic literature: the stories, homilies, and hymns on the saints that Christians of the Middle East told and preserved. It is our hope that our database will give scholars and students increased access to these traditions to generate new scholarship. The first volume, Qadishe or “saints” in Syriac, is a digital catalogue of saints or holy persons venerated in the Syriac tradition. Some saints are native to the Syriac-speaking milieu, whereas others come from other linguistic or cultural traditions. Through the translation of their hagiographies and the diffusion of saints’ cults in the late antique world, saints were adopted, “imported,” and appropriated into Syriac religious memory. The second volume, the BHSE, focuses on Syriac hagiographic texts. The BHSE contains the titles of over 1000 Syriac stories, hymns, and homilies on saints. It also includes authors’ or hagiographers’ names, the first and last lines of the texts (in Syriac, English, and French, bibliographic information, and the names of the manuscripts containing these hagiographic works. We have also listed modern and ancient translations of these works. All of the data in the Gateway to the Syriac Saints has been encoded in TEI, and it is fully
Lee, Jae Ho; Lim, Youngkyoung; Park, Ji-Hye; Lee, Jong Hee; Jang, Kee-Taek; Kwon, Eun Ji; Lee, Dong-Youn
Clinical distinction between nail matrix nevus (NMN) and subungual melanoma (SUM) can be challenging. More precise delineation of the clinicodermoscopic characteristics specific for NMNs is needed. We sought to analyze the clinicopathologic features of childhood and adult NMNs and to propose clinicodermoscopic features that can aid in differentiating NMNs from SUM. We retrospectively reviewed clinical, dermoscopic, and histologic findings of patients (20 children and 8 adults) in whom NMN was diagnosed between 2012 and 2015. Except for 2 cases of total melanonychia, the affected nails demonstrated longitudinal melanonychia sharply demarcated from the adjacent nail plate. Melanonychia was wider among children than among adults (P = .002). Nail dystrophy was more frequent in wider lesions (P = .028). Hutchinson's sign was observed in pediatric cases at the hyponychium and/or proximal nailfold cuticles. All hyponychial pigmentations demonstrated a longitudinal brush pigmentation pattern under dermoscopy. This was a retrospective study of Asians in a single center. Our study is the largest case series to date of biopsy-confirmed NMNs. It highlighted important clinicodermoscopic differences between pediatric and adult NMNs. We propose that in pediatric cases of longitudinal melanonychia presenting as a sharply demarcated pigment band of even width, the presence of Hutchinson's sign with longitudinal brush pigmentation may favor a diagnosis of NMN over SUM. Copyright © 2017 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Reibel, J; Wewer, U; Albrechtsen, R
Oral tumors of presumably neuroectodermal origin were stained with anti-laminin antibody by a double layered immunofluorescence technique. A marked positive staining for laminin was found in neurofibromas and neurilemmomas although the pattern of laminin distribution was slightly different...... in nests whole groups of cells were encircled by laminin as seen in the GCM. Ordinary oral fibromas included as controls were negative except for the expected positive staining of basement membranes normally occurring in the tissues. Immunohistochemical demonstration of laminin seems to be a valuable aid...... in differential diagnosis of soft tissue tumors and may provide useful information about the pathogenesis of various lesions....
Alby, E.; Grussenmeyer, P.; Bitard, L.; Guillemin, S.; Brunet-Gaston, V.; Gaston, C.; Rougier, R.
This paper is dedicated to the digitization of blocks and virtual anastylosis of an antique façade in Pont-Sainte-Maxence (France). In 2014 during the construction of a shopping center, the National Institute for Preventive Archaeological Research (INRAP) discovered a Gallo-Roman site from the 2nd century AD. The most interesting part of the site for the study is a façade of 70 meters long by nearly 10 meters high. The state of the conservation of the blocks of the façade makes them exceptional due to the question raised by the collapse. Representative and symbolic blocks of this building have been selected for a virtual anastylosis study. The blocks discovered belong to different types: decorated architectural blocks, monumental statuary elements and details of very fine decorations. The digital reproduction of the façade will facilitate the formulation of hypothesis for the collapse of the structure. The Photogrammetry and Geomatics Group from INSA Strasbourg is in charge of the digitization, the anastylosis and the development of exploratory methods for understanding the ruin of the façade. To develop the three-dimensional model of the facade, approximately 70 blocks of various dimensions were chosen by the archaeologists. The choice of the digitization technique is made according to the following pragmatic criterion: the movable objects are acquired with a scan-arm or a hand-held scanner in the laboratory and the largest blocks are recorded by photogrammetry at the repository near Paris. The expected types of deliverables are multiple: very accurate 3D models with the most faithful representation to document the objects in the best way and with optimized size model allowing easy handling during anastylosis tests. The visual aspect of the models is also a very important issue. Indeed, textures from photos are an excellent way to bring about the realism of the virtual model, but fine details of the object are sometimes blurred by the uniformity of the color
Full Text Available In the history of the Saintes-Chapelles the 13th century is a cornerstone, for the extraordinary semantic value given by king of France Louis IX to the palatine chapel, built on behalf of Sacred Crown of Christ and as emblem of the sacredness of the kingdom. In the theological and political arena of 13th-15th century Europe, this high symbolic value gives a strong power of representation of the royalty to the Sainte-Chapelle of Paris, making it also the subject of much imitation and reproduction by other courts. However, contrary to what one might think, the paradigms of such imitations and reproductions stay mutable for a long time, and they are not solely identifiable with the devotion to the Passion and the Blood of Christ. That is the context in which the foundation of the Sainte-Chapelle of the Savoy dukedom takes shape in Chambéry in the fifteenth century, with details, times and protagonists that this study considers. From this viewpoint, the theme of the Sainte-Chapelle joins with the objectives of an investigation of the politics of the Holy as explained by Ludovic Viallet in the Introduction, and studied through their articulation between central and local powers, political ideology and devotions, political and religious planning of space.
Larson-Higdem, Dana C.; Larson, S.P.; Norvitch, Ralph F.
The configuration of the water table as plotted at a contour interval of 20 feet (6 metres) on quadrangle maps (scale 1:2,500) of the Minneapolis-Saint Paul metropolitan area. Control points used for mapping were water levels in wells, lakes and sloughs, and places where topographic contours cross perennial streams.
This profile provides a snapshot of the energy landscape of the northeast Caribbean island Saint Martin. The island is divided between two nations, France in the north (Saint-Martin) and the Netherlands in the south (Sint Maarten).
Seifert, D. J.
SAINT (Systems Analysis of Integrated Networks of Tasks) is a network modeling and simulation technique for design and analysis of complex man machine systems. SAINT provides the conceptual framework for representing systems that consist of discrete task elements, continuous state variables, and interactions between them. It also provides a mechanism for combining human performance models and dynamic system behaviors in a single modeling structure. The SAINT technique is described and applications of the SAINT are discussed.
Paul Anthony Brazinski
Full Text Available ''The archaeology of smell is a burgeoning field in recent scholarship. This paper adds to existing literature by investigating the function of smell in relation to relic sales and veneration in medieval Europe, a hitherto understudied area of research. Collating historical texts concerning the translatio of saintly relics in Western Europe and the Byzantine Empire with archaeological sources associated with relic veneration and religious worship (including ampullae, unguentaria, sarcophagi, holy oils, pillow graves, and silk, this paper suggests that (1 smell was used in the medieval world as a means to challenge or confirm a relic’s authenticity, and (2 olfactory liquids that imbued or permeated material objects in the context of worship functioned as a means of focusing attention on relic veneration and were an essential part of the cult and/or pilgrimage experience.
С. А. Игнатьев
Full Text Available The paper addresses an issue of creating an environment favorable for the life in megacities by planting vegetation on the rooftops. It also provides information about rooftop greening practices adopted in other countries. The issues of ‘green roof’ building in climatic conditions of Saint Petersburg and roof vegetation impact on the urban ecosystem are examined. Vegetation composition quality- and quantity-wise has been proposed for the roof under research and a 3D model of this roof reflecting its geometric properties has been developed. A structure of roof covering and substrate qualitative composition is presented. An effect of rooftop geometry on the substrate temperature is explored. The annual substrate temperature and moisture content in different parts of the roof have been analyzed. Results of thermal imaging monitoring and insolation modelling for different parts of green roof surface are presented.
Nobre, Aretha Brito; Piñeiro-Maceira, Juan; Raggio Luiz, Ronir
BACKGROUND Dysplastic nevi are among the most important cutaneous melanoma simulators. They are important risk markers for this neoplasia and can be its potential precursors. Some authors found a statistically significant relationship between the degree of dysplasia and the risk for developing melanoma. However, reproducibility of grading criteria ranged from poor to fair in the researched articles. OBJECTIVE To test the reproducibility of the grading criteria proposed by Sagebiel et al. regarding dysplastic nevi. METHODS Histological specimens of 75 dysplastic nevi were graded, independently and in a blinded fashion, according to preestablished criteria, by a panel of 10 pathologists with different levels of experience. Diagnostic agreement was calculated using weighted kappa and intraclass correlation coefficients. RESULTS The average of weighted kappa values was 0.13 for all observers, 0.12 for dermatopathologists, 0.18 for general pathologists and 0.05 for residents. Intraclass correlation coefficient values were 0.2 for all observers, 0.18 for dermatopathologists, 0.33 for general pathologists and 0.15 for residents. CONCLUSIONS: Histopathological grading for dysplastic nevi was not reproducible in this Brazilian series, so the criteria used are not a helpful histopathological parameter for clinicopathological correlation. PMID:23539000
Stanford, Joseph B; Smith, Ken R
Utah has the highest total fertility of any state in the United States and also the highest proportion of population affiliated with the Church of Jesus Christ of Latter-day Saints (the LDS or Mormon Church). Data were used from the 1996 Utah Health Status Survey to investigate how annual household income, education and affiliation with the LDS Church affect fertility (children ever born) for married women in Utah. Younger age and higher education were negatively correlated with fertility in the sample as a whole and among non-LDS respondents. Income was negatively associated with fertility among non-LDS respondents. However, income was positively correlated with fertility among LDS respondents. This association persisted when instrumental variables were used to address the potential simultaneous equations bias arising from the potential endogeneity of income and fertility. The LDS religion's pronatalist stance probably encourages childbearing among those with higher income.
de Diego Cordero, Rocío; Badanta Romero, Bárbara
The aim of the study is to discuss the relationship between lifestyle marked by The Church of Jesus Christ of Latter-day Saints and health. PubMed, CINAHL, PsycINFO, WOS y Scopus were the databases used for this literature review, with these descriptors: "Mormons", "mormons religion", "health". Inclusion criteria were articles with full text available, published between 2005 and 2016, in English or Spanish language. Results show that following the restrictive Mormon doctrine generates beneficial effects for the health. Habits related to toxics and food, as well as social support, from family and Mormon community are an important basis for good health. On the other hand, not following the prescriptions or leaving the group, opposed sexual identities or not fulfilling the roles associated with women are associated with worse mental and physical health.
Chabrol, B; Fortin, G; Bernard-Bonnin, A C; Allard-Dansereau, C; Chabot, G; Methot, B
In Quebec, the Child's Protection law protects the child from birth until 18 years of age when child abuse or neglect is suspected. Since 1990, the program of the Child Protection Clinic of Sainte-Justine Hospital (Montreal) offers a special unit for evaluation and prevention of child abuse and neglect, constituted by a multidisciplinary team including five pediatricians. About 500 children are referred each year in external consultations or from hospital units. In addition, the pediatricians participate in the "programme Santé-Enfance-Jeunesse", a prevention program in the Montreal area. They also act as expert witnesses in court. Thus Quebec's pediatricians fully participate in a child's protection with their activities in different levels of diagnosis, management and prevention of child abuse and neglect.
Full Text Available In 2004, with the closing of the last Hmong refugee camp, Wat Tham Krabok, the latest group of Hmong refugees resettled to the US. To facilitate the language transition of approximately 1,000 school-aged newcomer Hmong children, the Saint Paul Public Schools, developed and established Transitional Language Centers. In this article, we examine the experiences and perspectives of principals, teachers and educational assistants who worked with newcomer Hmong children in the newly-established Transitional Language Centers and well-established Language Academy programs. We also elucidate the experiences of Hmong parents with the schools that served their children. Our research offers insights into the important work of the Transitional Language Centers as well as the need to better support newcomer Hmong parents.
Full Text Available Sarah Vuolo, Lisa Peters, Louis Licari Department of Emergency and Critical Care, Fox Valley Animal Referral Center, Appleton, WI, USA Abstract: A four-year-old neutered male Saint Bernard dog presented with a 2 year history of nasal philtrum ulceration and recent recurrent arterial hemorrhage from this region. Dermal arteritis of the nasal philtrum was diagnosed and the patient was started on immunosuppressive medications. Clinical signs continued to recur until surgical resection of the lesions was performed. Dermal arteritis of the nasal philtrum is a rare phenomenon but should be considered in certain breeds. Surgical removal of affected tissue should be considered when medical treatment fails. Long-term management with cyclosporine was initiated which has not been previously described in the literature. Keywords: dermal arteritis, immunology, nasal resection, immunosuppression
Girchenko, P; Ompad, D C; Kulchynska, R; Bikmukhametov, D; Dugin, S; Gensburg, L
Commercial sex workers (CSWs) in the Russian Federation are at high risk of HIV infection and transmission as a result of unsafe sexual and injecting behaviors. Their clients might be at increased risk of acquiring HIV; however, little is known about the population of men purchasing sex services. This study aims to investigate factors associated with a history of purchasing sex services by men in Saint Petersburg and Leningrad Oblast, Russian Federation. Data were collected as part of a cross-sectional study offering free anonymous rapid HIV testing in Saint Petersburg and Leningrad Oblast in 2014; in total, 3565 men aged 18 years and older provided information about their behaviors associated with risk of acquiring HIV during face-to-face interviews. Prevalence of CSW use in our study was 23.9%. Multivariable analyses using log-binomial regression were stratified by self-reported HIV testing during the 12 months preceding the study interview. In both strata, older age, multiple sex partners, and a history of sex with an injection drug user (IDU) were associated with an elevated prevalence ratio (PR) for history of purchasing sex services, although the strength of the association differed by strata. Among men who reported recent HIV testing, condom use (PR = 1.22, 90% confidence interval (CI) 1.0, 1.48) was associated with a history of purchasing sex services, and among men who did not report recent HIV testing, having a consistent sex partner was associated with purchasing sex services (PR = 1.23, 90% CI 1.1, 1.37). The high prevalence of CSW service use and associations found in this study raise serious concerns about potential for sexual HIV transmission and should be investigated more closely.
Full Text Available Un échantillonnage systématique des principaux affleurements des séries carbonatées néogènes de Sainte Croix (Iles Vierges a permis de préciser leur extension stratigraphique. C'est ainsi que la section-type de la formation Kingshill, qui avait été récemment attribuée au Miocène supérieur, est désormais datée du Miocène moyen d'après son riche contenu faunistique en foraminifères planctoniques et nannofossiles calcaires. Les diverses mesures pétrophysiques effectuées dans des niveaux d'environnement de dépôts différents (plate-forme, pente, bassin tendent à prouver que de bonnes porosités et perméabilités, donc de bons réservoirs, pourraient être trouvées dans des séries de pentes ou de fond de bassins associés à des plates-formes carbonatées. Systematic sampling of the main outcrops of Neogene carbonate series on Saint Croix, Virgin Islands, has enabled their stratigraphic extension to be determined. In this way, the Kingshill formation type section, which has recently been attributed to the late Miocene, is henceforth dated from the middle Miocene according to planktonic foraminifers and calcareous nannofossils. The different petrophysical measurements made in strata originated from different depositional environments (shelf, slope, basin tend to prove that good porosities and permeabilities, hence good reservoirs, might be found in slope or basin-bottom series associated with carbonate banks.
Barton, Emma J; Tennyson, Jonathan; Béguier, S; Campargue, A
A Fourier Transform (FT) absorption spectrum of room temperature NH3 in the region 7400 - 8600 cm-1 is analysed using a variational line list and ground state energies determined using the MARVEL procedure. The spectrum was measured by Dr Catherine de Bergh in 1980 and is available from the Kitt Peak data center. The centers and intensities of 8468 ammonia lines were retrieved using a multiline fitting procedure. 2474 lines are assigned to 21 bands providing 1692 experimental energies in the range 7000 - 9000 cm-1. The spectrum was assigned by the joint use of the BYTe variational line list and combination differences. The assignments and experimental energies presented in this work are the first for ammonia in the region 7400 - 8600 cm-1, considerably extending the range of known vibrational-excited states
Goodson, Agnessa Gadeliya; Florell, Scott R.; Boucher, Kenneth M.; Grossman, Douglas
Background Little is known about the recurrence/persistence rates of dysplastic nevi (DN) following biopsy, and whether incompletely removed DN should be re-excised to prevent recurrence. Objective Our purpose was to determine the recurrence rates of previously biopsied DN, and to assess whether biopsy method, margin involvement, congenital features, epidermal location, and degree of dysplasia are associated with recurrence. Methods Patients having a history of nevus biopsy at least two years prior were assessed for clinical recurrence. Slides of original lesions were re-reviewed by a dermatopathologist. Results A total of 271 nevus biopsy sites were assessed in 115 patients. Of 195 DN with greater than two years of follow-up, seven (3.6%) demonstrated recurrence on clinical exam. Ninety-eight DN had a follow-up period of at least four years with no clinical recurrence. Of 61 benign nevus biopsy sites examined, clinical recurrence was observed in two (3.3%). For all nevi, recurrence was significantly associated with shave biopsy technique but not with nevus dysplasia or subtype, or the presence of positive margin or congenital features. Limitations Most biopsies were performed in a pigmented lesion clinic at a single tertiary referral center. Determinations of nevus recurrence were made on clinical rather than histologic grounds, and follow-up times were limited in some cases. Conclusion In this cohort, rates of clinical recurrence following biopsy of dysplastic and benign nevi were extremely low. Re-excision of nevi, including moderately dysplastic nevi with a positive margin, may not be necessary. PMID:20018406
Hamed Nazarpour najafabadi
Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay. Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible. The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith. In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have
Full Text Available Faith has a central place in Abrahamic religions. Jewish, Christian and Moslem thinkers have conducted several studies of the notion of faith and offered different ideas. Fakhri Razi and Saint Paul, two thinkers from Islamic and Christian religious traditions, have commented on the matter at length and these comments and ideas are studied in this essay. Paul the Apostle (died 64 AD is the most famous and influential Christian figure and is known as the second founder of Christianity. He has an indispensable role in formulating Christian doctrines. At first, he was a Jew and after the revelation of Jesus, converted to Christianity and dedicated himself to evangelism. The only credible reports and first hand sources about the lives and beliefs of Paul are the Acts of the Apostles and his letters and epistles in the Bible. The background of the debate on faith should be sought for in the Old Testament. In the Old Testament, belief means trusting in God, relying on Him, and recognizing and acknowledging the special relationship that God has established with Israel. In the New Testament, belief has a significant position too. Faith in the New Testament is more epistemic and cognitive and means certain belief and conviction. According to Paul faith is the basic principle of Christianity and outstanding feature of Christians and the main cause of salvation. In the early Christianity, Paul offers the most extensive and most profound exposition of faith. In defining faith, Paul uses Greek word «pistis» which means confidence, faith and trust. In definition of faith, he says: "Faith is the confidence that what we hope will be, and faith is the certainty of what we believe, although we are not able to see them "(Hebrews, 11/1. He mentions Abraham as a distinguished example for introducing true faith and faithful. Faith in Jesus means to trust or have confidence in Jesus Christ. According to Paul, faith is based on hope in things which have
Bhattacharjee, Kasturi; Singh, Manpreet; Bhattacharjee, Harsha
Two patients with congenital divided nevi of the eyelids presented with chief symptoms of cosmetic blemish (n=2) and epiphora (n=1). All the lesions were surgically excised with histological free margins and amniotic membrane graft (AMG) was used to cover the mucosal and eyelid marginal defects. Caruncular and punctal involvement was managed with complete excision and monocanalicular stent insertion to prevent punctal stenosis. AMG provided an adequate scaffold for conjunctival regenesis and anatomic continuity was found within 6 weeks in both patients. None of them had any residual pigmentation or disease recurrence after a follow-up of more than 2.5 years. Local absence of eyelashes was the only drawback which patients masked with modern artificial eyelashes or make-up. This novel utility of AMG illustrates effective conjunctival regenesis and maintenance of mucocutaneous junction functionality. 2015 BMJ Publishing Group Ltd.
Farrugia, Michael; Hurley, Neil; Quigley, Aaron
Whenever the actors of a social network are not uniquely identifiable in the data, then entity resolution in the form of actor identification becomes a critical facet of a social network construction process. Here we develop SAINT, a pipeline for supervised entity resolution that uses relational information to improve, or tune, the quality of the constructed network. The first phase of SAINT uses attribute only based entity resolution to create an initial social network. Relational information between actors, actor network properties and other relational output of the first classification phase, are used in a second phase to improve the results of the original entity resolution. When compared to single phased approaches, the results from this two phased approach are consistently superior in both recall and precision measures. Embedded within SAINT are a series of evaluation checkpoints designed to measure both the quality of the individual classifiers and their impact within the entire pipeline. Our evaluation results provide insight on the potential propagation of error and open research questions for further improvement of the individual classifiers within the entire pipeline. As the main application of the process is to improve actor identification in social networks, we characterise the impact that entity resolution has on the final constructed network. We compare the network constructed using SAINT with a ground truth network using perfect entity resolution and use global and local network measures to study the differences.
Harvard Univ., Cambridge, MA. Center for Field Studies.
The feasibility of centralizing elements of the educational process in Saint Paul, Minnesota provided the premise for proposed long range solutions to the educational needs of the community. The role of education in the community was explored by staff specialists in school organization, curriculum design, and urban planning. Research design relied…
Serpil, S; Ulku, K; Cemil, C; Nasuhi Engin, A; Sezai, S; Meryem, I
Melanocytic skin tumors are caused by nevus cells, epidermal melanocytes and dermal melanocytes. The aim of the study was to detect the positivity of Demodex spp. in biopsy specimens of skin diagnosed as nevus. In this retrospective study, the specimens obtained from 110 patients diagnosed with nevus and stained by hematoxylin & eosin (H&E) method were assessed for Demodex. Statistical analysis was done using independent sample t test, Pearson Chi-square and Yates' adjusted Chi-square test. For statistics, p < 0.05 was considered significant. Consequently, 43 (39.1%) out of 110 specimens were detected to have Demodex spp. Demodex colonization augmented in nevi can be explained by the possible affinity of the parasite to the melanin pigment.
Keske, Catherine,; Dare, Jennifer,; Hancock, Tiffany; King, Myron
International audience; This article presents a case study of the Saint-Pierre and Miquelon (France) archipelago in order to identify the network and flow of agricultural resources within the circumpolar northern hemisphere known as a “boreal ecosystem” or “boreal ecozone”. We emphasize that climate and the existence of food insecurity within wealthy nations should be factored into conceptualizations of food sovereignty and food justice. The self-governing territory’s remote distance from the...
St-Onge, G.; Duboc, Q.; Boyer-Villemaire, U.; Lajeunesse, P.; Bernatchez, P.
Sediment cores were sampled in the estuary of the Nelson and Churchill Rivers in western Hudson Bay, as well as in the estuary of the Moisie and Sainte-Marguerite Rivers in Gulf of St. Lawrence in order to evaluate the impact of hydroelectric dams on the sedimentary regime of these estuaries. The gravity cores at the mouth of the Nelson River recorded several cm-thick rapidly deposited layers with a reverse to normal grading sequence, indicating the occurrence of hyperpycnal flows generated by major floods during the last few centuries. These hyperpycnal flows were probably caused by ice-jam formation, which can increase both the flow and the sediment concentration following the breaching of such natural dams. Following the construction of hydroelectric dams since the 1960s, the regulation of river discharge prevented the formation of hyperpycnal flows, and hence the deposition of hyperpycnites in the upper part of the cores. In the core sampled in the estuary of the Churchill River, only one hyperpycnite was recorded. This lower frequency may be due to the enclosed estuary of the Churchill River, its weaker discharge and the more distal location of the coring site.In the Gulf of St. Lawrence, grain size measurements allowed the identification of a major flood around AD 1844±4 years in box cores from both the Sainte-Marguerite and Moisie Rivers, whereas a drastic decrease in variations in the median grain size occurred around AD ~1900 in the estuary of the Sainte-Marguerite River, highlighting the offshore impact of the SM1 dam construction in the early 1900s. Furthermore, sedimentological variations in the box cores from both estuaries have been investigated by wavelet analysis and the sharp disappearance of high frequencies around AD 1900 in the estuary of the dammed river (Sainte-Marguerite River), but not in the estuary of the natural river (Moisie River), also provides evidence of the influence of dams on the sedimentary regime of estuaries.
to avoid warping and splitting which sometimes occurs while drying fragile, waterlogged mat- enials. Results: Trench F Privy The stratigraphic zone of...archeological investigations; (3) environ- mental setting of the study area; (4) methodology , statement of project ob- jectivies, implementation and
Kourova, Natacha; Caro, Valérie; Weber, Christian; Thiberge, Sabine; Chuprinina, Raisa; Tseneva, Galina; Guiso, Nicole
We analyzed the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg that were collected between 1998 and 2000 and compared them with isolates collected 40 years ago and Russian vaccine strains. The analysis involved serotyping, pulsed-field gel electrophoresis of chromosomal DNA after digestion with XbaI and SpeI, and sequencing of the ptxS1 and prn genes, which encode the S1 subunit of the pertussis toxin and the major adhesin pertactin, respectively. The Russian isolates were classified in five of the six pulsed-field gel electrophoresis groups identified in other European countries. The B. pertussis isolates currently circulating in Saint Petersburg differed from the Russian whole-cell vaccine strains and the isolates collected in the prevaccine era. However, their repartition in the major pulsed-field gel electrophoresis groups was slightly different from that of isolates collected in countries that have had a high level of vaccine coverage for a long time, probably because the level of vaccine coverage in Saint Petersburg has increased only recently, after decreasing until the early 1990s. Most of the B. parapertussis isolates studied were similar to those circulating in France. However, some variants were observed, perhaps because B. parapertussis infections are more common in children in this area. PMID:12904379
Pacca, Carolina Colombelli; Marques, Rafael Elias; Espindola, José Wanderlan P; Filho, Gevânio B O Oliveira; Leite, Ana Cristina Lima; Teixeira, Mauro Martins; Nogueira, Mauricio L
Arboviruses, arthropod-borneviruses, are frequency associated to human outbreak and represent a serious health problem. The genus Flavivirus, such as Yellow Fever Virus (YFV) and Saint Louis Encephalitis Virus (SLEV), are important pathogens with high morbidity and mortality worldwide. In Brazil, YFV is maintained in sylvatic cycle, but many cases are notified annually, despite the efficiency of vaccine. SLEV causes an acute encephalitis and is widely distributed in the Americas. There is no specific antiviral drugs for these viruses, only supporting treatment that can alleviate symptoms and prevent complications. Here, we evaluated the potential anti-YFV and SLEV activity of a series of thiosemicarbazones and phthalyl-thiazoles. Plaque reduction assay, flow cytometry, immunofluorescence and cellular viability were used to test the compounds in vitro. Treated cells showed efficient inhibition of the viral replication at concentrations that presented minimal toxicity to cells. The assays showed that phthalyl-thiazole and phenoxymethyl-thiosemicarbazone reduced 60% of YFV replication and 75% of SLEV replication. Copyright © 2016 Elsevier Masson SAS. All rights reserved.
Full Text Available The island of Saint-Louis of Senegal was awarded the status of world heritage site by UNESCO in 2000 as an “outstanding example” of urban heritage. This island city comes with a unique heritage: development planning that combines a strong historical French influence with a gridiron urban morphology and building typology. The island must be interpreted within its total territorial context that includes both the island of Sor (on the mainland and La Langue de la Barberie, a sandy barrier that separates the mouth of the river from the sea. The city of Saint-Louis itself has grown enormously and haphazardly from the latter part of the 20th century: it is now the fourth most populous city in Senegal. At present, the city is undergoing a serious period of decline and recession due, in part, to the overriding influence of the capital, Dakar, and the centralized political forces in the country. This article looks at the key morphological and functional reasons behind the development and evolution of the island of Saint-Louis and that persist in the present context, with justifications for the deep-rooted heritage values that maintain its prestige as a World Heritage Site.
Girchenko, P; Ompad, D C; Bikmukhametov, D; Gensburg, L
Widespread use of unsafe sexual practices among women injecting drugs both practicing and not practicing sex work leads to high levels of unplanned pregnancies in this population. The goal of this study was to investigate the association between pregnancy and active drug use and sex work. Data were collected using a convenience sample of 500 women in Saint Petersburg, Russia, in 2013. All women had recent experience of drug use, of which 200 were pregnant at the time of the study. The study consisted of a structured interview followed by a rapid HIV test. Pregnancy was protective against both active drug use and sex work. For HIV-positive women, these associations were stronger than for HIV-negative women: drug use prevalence ratio (PR) was 0.59 vs 0.85; for sex work, the PRs were 0.36 vs 0.64. Higher levels of education were associated with a lower prevalence ratio for active drug use and sex work in all models. Having children was not associated with active drug use or sex work. Pregnancy might be an optimal time for conducting interventions aimed at cessation of drug use and sex work among women injecting drugs.
Full Text Available In recent years under the conditions of climate change the increased trend towards damages, rot and decline of woody plants at Arboretum of Komarov Botanical Institute RAS has been observed. As a result of 2-year mycological investigation (2012-2013 the wide distribution of phytophthoras has been detected in rhizosphere of many plants and 5 species of Phytophthora have been identified. All of them are soil-borne root-infecting species dangerous to plants growing at Botanical garden BIN: Ph. cinnamomi, Ph. cactorum, besides Ph. citricola, Ph. plurivora and Ph.quercina are firstly recorded in Russia. Ph. quercina is well known in Central and South Europe, but has not been observed yet in the northern latitudes of St. Petersburg. The infection of rhizosphere soil by these dangerous pathogenes has been found in 20 species of trees and shrubs from 15 genera and 13 families. The average year temperature in Saint-Petersburg during the first 13 years of the Third Millennium had ups on 0.5o and reached 6.3o . Temperature of the December, 2006 (3.0o C, July, 2010 (24.4o C and November, 2013 (4.4o C appeared to be the highest during the whole period of observations since 1743. The increase in temperature has been accompanied by the enhancement of precipitation. The highest amount of precipitation (863 mm for the whole period of observations was observed in 2012. The duration of phenological autumn for the same period has enlarged by 12 days, the spring seasons has shortened by 11 days. The duration of winter has shortened by 5 days (from 116 till 111 days, though this is still the longest season of the year (30% . Autumn is the second season in its longevity (94 days, 26% of the year. There is the tendency to more late beginning of autumnal phenostages of Calendar of Nature and the later beginning of winter. The start of spring also takes place at later dates. The summer phenostages have the tendency to start at more yearly dates. The increasing wetting of
Full Text Available For a long time consigned to oblivion, the figure of the soldier and naturalist Bory de Saint-Vincent has been during recent years the subject of a renewed but timid interest. This recovery is justified especially for his role as leader of the French missions in the Morea and Algeria, which replicated the military-scientific model that started in Egypt. Indeed, this leadership and the works of anthropology or botany that he produced as a result are now considered key elements in the process of construction of a modern unitary representation of the Mediterranean. These recent contributions, however, often do not consider other of his works that offer a much more complex and contradictory image of his thought. This article offers a review of recent interpretation by giving examples of his works on the Iberian Peninsula and the Canary Islands. It aims to show his representation of the Mediterranean not as a homogeneous and linear process but as the result of an ambivalent approach that led to both a unitary image and a simultaneous internal differentiation of the region.
Durante largo tiempo relegada al olvido, la figura del militar y naturalista Bory de Saint-Vincent ha sido en los últimos años objeto de un renovado aunque tímido interés. Esta recuperación se justifica especialmente por su papel como líder de las misiones francesas en Morea y Argelia, que reprodujeron el modelo de expedición científico-militar planteado en Egipto. Precisamente, este liderazgo y los trabajos de antropología o botánica que él mismo llevó a cabo en dichas misiones se consideran actualmente como elementos fundamentales en el proceso de construcción de una moderna representación unitaria del Mediterráneo. Estas aportaciones recientes, sin embargo, no suelen considerar otros trabajos del militar-naturalista que ofrecen una imagen mucho más compleja y contradictoria de su pensamiento. En este artículo se ofrece una revisión de la reciente
Full Text Available Albeit halo nevi are estimated to be present in approximately 1% of the general population, and they are found to be more prevalent in people with vitiligo, malignant melanoma or Ullrich-Turner’ s syndrome, it is not necessary evident that their presence in human body is to be associated to vitiligo and/or melanoma, both genetically and pathophisiologically. In this study I want to demonstrate how it can be safe to expose Sutton’s nevi (halo nevi to all the sun rays (even the most dangerous during all the daylight, employing two natural cosmetic items: the former based on natural juleps made of polychrome algae (and it is to be considered the absorber sun filter and the latter is a physical sun blocking agent, apt to reflect all the UV rays. The former must be spread onto the halo, the latter, after half an hour, onto the nevus itself.
Full Text Available The article deals with of St. Augustine and St. Filaret’s of Moscow views on state involvement in the conversion of heretics and schismatics to Orthodoxy. The study of St. Augustine and St. Filaret’s views on public authorities involved in the conversion of heretics and schismatics allows to have a fresh look at the value of coercive measures for the mission of the Church. Despite the fact that one of the authors lived at the dawn of the Orthodox Empire, and the other observed its decline, the theological issues of the question of compulsion in matters of faith has not signiﬁcantly changed. Using measures of the state compulsion does not imply the termination of the church preaching. Without church activity coercion by the state is not generally allowed. These measures, in Saint’s opinion, are necessary to remove obstacles to joining the church unity to those who have already appealed to the Orthodox faith, but because of ingrained habits, are in schism. Of course, the external retaining factors are relevant only for the weak Christians, but it is very diﬃcult for them to overcome external obstacles to the Church without help of the state, and in some cases even impossible.
Une socialisation professionnelle par l’histoire : la formation morale des Saint-Cyriens et le martyrologe patriotique Being professionally socialized by History : the moral training of Saint-Cyr cadets and the legend of patriotic martyrs
Full Text Available À travers l’étude de l’École Spéciale Militaire de Saint-Cyr Coëtquidan, l’article montre comment la formation des officiers français de recrutement direct repose sur une préparation pensée comme tripartite : militaire, académique et « morale ». Cette dernière dimension suppose notamment la transmission d’une mémoire collective, qui peut être étudiée comme un facteur de socialisation professionnelle. Non sans évoquer les limites d’un tel mécanisme, l’article entend montrer comment la magnification et la remémoration constante des hauts faits de l’histoire militaire, et tout particulièrement des sacrifices pro patria, peuvent servir à fortifier le patriotisme des élèves-officiers. En utilisant les résultats d’une enquête quantitative menée de manière synchronique auprès des élèves de l’ESM à leur entrée et à leur sortie de l’école, on aboutit toutefois au constat que l’école concourt à fortifier ces valeurs plus qu’elle ne les produit, et que le temps aidant, l’exaltation initiale des élèves pour les éléments absolus de l’engagement se nuance d’une connaissance plus empirique des réalités du métier.Using data gathered while researching the Special Military Academy (École Spéciale militaire of Saint-Cyr Coëtquidan in 2002, this article shows that the training of future French officers can be subdivided into three different sorts of instruction : military, academic and “moral”. The interest of the latter is that it seems to take advantage of the transmission of the memory of former officers having laid down their lives for France as a means to reinforce the cadets’ patriotism. The article points to the fact that cadets are often already convinced of the importance of patriotism and other military values upon entering the military academy. Moreover, with the passage of time, the cadets’ enthusiasm for bravery and sacrifice seems to cool slightly, as they slowly
Full Text Available A polychrome wooden sculpture from the Museum of Santa Maria de Lamas (Northern Portugal, representing the image of Saint Dominic, produced in the first half of the 18th century, was studied for the identification of the materials and techniques employed in its fine modelling. Radiography was used for the study of the construction details of the wooden support, optical microscopy (OM and polarized light microscopy (PLM for the characterization of the paint layers and energy dispersive X-ray spectrometry (EDXRF, Fourier transform infrared spectroscopy (FTIR and microchemical tests for the identification of pigments and fillers.The identified materials were common to the period when the sculpture was made: gypsum, gold leaf, bole,white lead, brown ochre, vermillion, a black pigment made of carbon (possibly mixed with verdigris, used as a drier, a red lake and a calcium compound used as filler. However, regarding the techniques employed, and probably due to economic reasons, it seems that the recommended practice in art treatises and working contracts was not completely followed in what concerns the ground layers. Similar reasons appear to have caused the use of white lead mixed with a calcium compound, as a filler, in the less expressive areas, and should explain the fact that the estofado techniques (simulation of brocaded vestment have been limited to the visible areas at the front.
Full Text Available Accurate knowledge of temperate glacier mass balance is essential to understand the relationship between glacier and climate. Defined as the reflected fraction of incident radiation over the whole solar spectrum, the surface broadband albedo is one of the most important variable in a glacier's mass balance. This study presents a new method to retrieve the albedo of frozen surfaces from terrestrial photography at visible and near infrared wavelengths. This method accounts for the anisotropic reflectance of snow and ice surfaces and uses a radiative transfer model for narrow-to-broadband conversion. The accuracy of the method was assessed using concomitant measurements of albedo during the summers 2008 and 2009 on Saint Sorlin Glacier (Grandes Rousses, France. These albedo measurements are performed at two locations on the glacier, one in the ablation area and the other in the accumulation zone, with a net radiometer Kipp and Zonen CNR1. The main sources of uncertainty are associated with the presence of high clouds and the georeferencing of the photographs.
Full Text Available The European view of economic competition, which is the European Parliament view and enforced by the European Commission does not have a coherent theory of efficiency in allocating resources and justice on a market. The positive law proceeds at incriminating and penalizing with arbitrarily fixed fines the players on different markets but not offering a definition of what competition or free market means, not to mention a theory of the firm. It delivers, of course, a sort of theory, but we argue that it is not coherent and moreover, pretends to be what it cannot possible be, nam¬ely free of any value judgments. The present paper exposes an alternative view to the theory used by EC when decided to fine with 1.4 billion euros the European car glass suppliers Saint-Gobain, Pilkington, AGC and Soliver for cartelizing, and it also presents the case from the perspective of free competition theory based on private property rights of owners.
Silva,Amaro E. T.; Guimarães, Larissa A.; Ferreira,Elthon G.; Torres, Maria da Conceição M.; Silva, Alison B. da; Branco, Paola C.; Oliveira, Francisca Andréa S.; Silva, Genivaldo G Z; Wilke, Diego V.; Silveira,Edilberto R.; Pessoa,Otília Deusdenia L; Jimenez, Paula C.; Leticia V. Costa-Lotufo
The actinomycete strain BRA 177 was recovered from sediment samples collected at the St. Peter and St. Paul Archipelago, Brazil. This work accessed the ability of this strain, identified as Actinomadura sp., to produce bioactive metabolites by exploring the genome and characterizing chemistry and cytotoxicity of isolated compounds. From the crude ethyl acetate extract, the pigments nonylprodigiosin, cyclononylprodigiosin and methylcyclooctilprodigiosin were isolated and displayed cytotoxicity...
... sensitive personal information, such as ] an individual's Social Security Number; date of birth; driver's... certain other assets owned or controlled by Saint-Gobain relating to the research, development, marketing... to the Commission prior to leasing or selling the Latrobe, Pennsylvania facility or selling...
contributed to high rates of obesity. In Trinidad and Tobago and St Kitts-Nevis, for example, local produce comprises less than 10% of school meals, ... contribute to healthier lifestyles for children. Emerging outcomes. Drip irrigation for increased year- round production. In St Kitts-Nevis and other parts of the Eastern.
... Guinea Guinea-Bissau Guyana Haiti Heard Is and McDonald Is Holy See Honduras Hong Kong Hungary Iceland ... Poland Portugal Qatar Republic of Congo Reunion Romania Russia Rwanda Saint Barthelemy Saint Helena Saint Kitts and ...
Congenital melanocytic nevi of the face are a frequent reason for consultation in paediatric plastic surgery. Usually of small size, they raise a complex problem of reconstruction when they are large and giant. The indication of excision is generally stated on aesthetic criteria whereas the risk of melanoma is especially important in the giant nevi. Simple suture, full thickness skin graft and expanded skin flaps are the techniques of choice. The treatment must be carried out precociously, follow a surgical planning, respect the aesthetic units of the face and the periorificial areas, adapt to the age of the child and bring psychological benefit to the child. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
To celebrate the CERN 50th anniversary and to emphasize the close ties between the community of Saint-Genis-Pouilly, CERN and the ALICE Collaboration, Hubert Bertrand, Mayor of Saint-Genis-Pouilly and Christian Fabjan, Technical Coordinator of the ALICE Experiment, planted a tree on Saturday 16 October 2004 in front of the Jean Monet Culture Center.
To celebrate the CERN 50th anniversary and toÂ emphasize the close ties between the community of Saint-Genis-Pouilly, CERN and the ALICE Collaboration, Hubert Bertrand,Â Mayor of Saint-Genis-Pouilly andÂ Christian Fabjan, Technical Coordinator of the ALICE Experiment, planted a tree on Saturday 16 October 2004 in front of the Jean Monet Culture Center.
Mercedes B. Fuertes
Full Text Available The MHC class I chain-related protein A (MICA is an inducible molecule almost not expressed by normal cells but strongly up-regulated in tumor cells. MICA-expressing cells are recognized by natural killer (NK cells, CD8+ aßTCR and ?dTCR T lymphocytes through the NKG2D receptor. Engagement of NKG2D by MICA triggers IFN-? secretion and cytotoxicity against malignant cells. Although most solid tumors express MICA and this molecule is a target during immune surveillance against tumors, it has been observed that high grade tumors from different histotypes express low amounts of cell surface MICA due to a metalloprotease- induced shedding. Also, melanomas develop after a complex process of neotransformation of normal melanocytes. However, the expression of MICA in premalignant stages (primary human quiescent melanocytic nevi remains unknown. Here, we assessed expression of MICA by flow cytometry using cell suspensions from 15 primary nevi isolated from 11 patients. When collected material was abundant, cell lysates were prepared and MICA expression was also analyzed by Western blot. We observed that MICA was undetectable in the 15 primary nevi (intradermic, junction, mixed, lentigo and congenital samples as well as in normal skin, benign lesions (seborrheic keratosis, premalignant lesions (actinic keratosis and benign basocellular cancer. Conversely, a primary recently diagnosed melanoma showed intense cell surface MICA. We conclude that the onset of MICA expression is a tightly regulated process that occurs after melanocytes trespass the stage of malignant transformation. Thus, analysis of MICA expression in tissue sections of skin samples may constitute a useful marker to differentiate between benign and malignant nevi.
Goodson, Agnessa Gadeliya; Florell, Scott R; Boucher, Kenneth M; Grossman, Douglas
Little is known about the recurrence/persistence rates of dysplastic nevi (DN) after biopsy, and whether incompletely removed DN should be re-excised to prevent recurrence. Our purpose was to determine the recurrence rates of previously biopsied DN, and to assess whether biopsy method, margin involvement, congenital features, epidermal location, and degree of dysplasia are associated with recurrence. Patients having a history of a "nevus biopsy" at least 2 years earlier were assessed for clinical recurrence. Slides of original lesions were re-reviewed by a dermatopathologist. A total of 271 nevus biopsy sites were assessed in 115 patients. Of 195 DN with greater than 2 years of follow-up, 7 (3.6%) demonstrated recurrence on clinical examination. In all, 98 DN had a follow-up period of at least 4 years with no clinical recurrence. Of 61 benign nevus biopsy sites examined, clinical recurrence was observed in two (3.3%). For all nevi, recurrence was significantly associated with shave biopsy technique but not with nevus dysplasia or subtype, or the presence of positive margin or congenital features. Most biopsies were performed in a pigmented lesion clinic at a single tertiary referral center. Determinations of nevus recurrence were made on clinical rather than histologic grounds, and follow-up times were limited in some cases. In this cohort, rates of clinical recurrence after biopsy of DN and benign nevi were extremely low. Re-excision of nevi, including mildly to moderately DN with a positive margin, may not be necessary. Copyright 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Malignant melanoma is a highly malignant tumor, and its response to treatment is poor. Its incidence is on an increase world-wide. Amplified surface microscopy is a riew non-invasive diagnostic method enabling the detection of atypical (dysplastic) nevi, which are frequent precursors of malignant melanoma, as well as of signs that indicate the initial symptoms of malignant afteration much earlier than it used to be possible by a standard clinical examination. Therefore, our study was aimed at...
Fissore, C; Baker, L A; Hobbie, S E; King, J Y; McFadden, J P; Nelson, K C; Jakobsdottir, I
Rapid worldwide urbanization calls for a better understanding of the biogeochemical cycling of those macroelements that have large environmental impacts in cities. This study, part of the Twin Cities Household Ecosystem Project, quantified fluxes of carbon (C), nitrogen (N), and phosphorus (P) at the scale of individual households in the Minneapolis-Saint Paul metropolitan area in Minnesota, USA. We estimated input and output fluxes associated with several components of household activities including air and motor vehicle travel, food consumption, home energy use, landscape, pets, and paper and plastic use for 360 owner-occupied, stand-alone households. A few component fluxes dominated total input fluxes of elements. For instance, air and motor vehicle transportation, together with home energy use, accounted for 85% of total C consumption and emissions. All total and component fluxes were skewed to varying degrees, suggesting that policies targeting disproportionately high fluxes could be an effective and efficient way to reduce pollution. For example, 20% of households contributed 75% of air travel emissions and 40% of motor vehicle emissions. Home energy use was more nearly normally distributed. Nitrogen fluxes were dominated by human diet and lawn fertilizer applications, which together accounted for 65% of total household N inputs. The majority of P inputs were associated with human diet, use of detergents, and pet food. A large portion of the variation among household fluxes of C, N, and P was related to a few biophysical variables. A better understanding of the biophysical, demographic, and behavioral drivers of household activities that contribute to C, N, and P fluxes is pivotal for developing accurate urban biogeochemical models and for informing policies aimed at reducing sources of pollution in urban ecosystems.
Gareau, Dan; Hennessy, Ricky; Wan, Eric; Pellacani, Giovanni; Jacques, Steven L.
In-vivo reflectance confocal microscopy (RCM) shows promise for the early detection of superficial spreading melanoma (SSM). RCM of SSM shows pagetoid melanocytes (PMs) in the epidermis and disarray at the dermal-epidermal junction (DEJ), which are automatically quantified with a computer algorithm that locates depth of the most superficial pigmented surface [DSPS(x,y)] containing PMs in the epidermis and pigmented basal cells near the DEJ. The algorithm uses 200 noninvasive confocal optical sections that image the superficial 200 μm of ten skin sites: five unequivocal SSMs and five nevi. The pattern recognition algorithm automatically identifies PMs in all five SSMs and finds none in the nevi. A large mean gradient ψ (roughness) between laterally adjacent points on DSPS(x,y) identifies DEJ disruption in SSM ψ = 11.7 +/- 3.7 [-] for n = 5 SSMs versus a small ψ = 5.5 +/- 1.0 [-] for n = 5 nevi (significance, p = 0.0035). Quantitative endpoint metrics for malignant characteristics make digital RCM data an attractive diagnostic asset for pathologists, augmenting studies thus far, which have relied largely on visual assessment.
Kari J Ekenstedt
Full Text Available An inherited polyneuropathy (PN observed in Leonberger dogs has clinical similarities to a genetically heterogeneous group of peripheral neuropathies termed Charcot-Marie-Tooth (CMT disease in humans. The Leonberger disorder is a severe, juvenile-onset, chronic, progressive, and mixed PN, characterized by exercise intolerance, gait abnormalities and muscle atrophy of the pelvic limbs, as well as inspiratory stridor and dyspnea. We mapped a PN locus in Leonbergers to a 250 kb region on canine chromosome 16 (Praw = 1.16×10-10, Pgenome, corrected = 0.006 utilizing a high-density SNP array. Within this interval is the ARHGEF10 gene, a member of the rho family of GTPases known to be involved in neuronal growth and axonal migration, and implicated in human hypomyelination. ARHGEF10 sequencing identified a 10 bp deletion in affected dogs that removes four nucleotides from the 3'-end of exon 17 and six nucleotides from the 5'-end of intron 17 (c.1955_1958+6delCACGGTGAGC. This eliminates the 3'-splice junction of exon 17, creates an alternate splice site immediately downstream in which the processed mRNA contains a frame shift, and generates a premature stop codon predicted to truncate approximately 50% of the protein. Homozygosity for the deletion was highly associated with the severe juvenile-onset PN phenotype in both Leonberger and Saint Bernard dogs. The overall clinical picture of PN in these breeds, and the effects of sex and heterozygosity of the ARHGEF10 deletion, are less clear due to the likely presence of other forms of PN with variable ages of onset and severity of clinical signs. This is the first documented severe polyneuropathy associated with a mutation in ARHGEF10 in any species.
Onishchenko, G G
In 2006, being the presiding country at the Group of Eight Summit for the first time, Russia proposed the issue of counteraction with infectious diseases as one of the priority issues. In addition to the realization of the priority National Health Project, which is to a large degree dedicated to the immunoprophylaxis of infectious diseases as well as the prevention and treatment of HIV-infection/AIDS and hepatites B and C, a meeting of the Presidium of Russian Federation State Council presided by President V. V. Putin, dedicated to the problem of HIV-infection epidemic spread, was held on April 21; the meeting resulted in the formation of Governmental Commission on the problems of HIV-infection/AIDS. On July 16, the leaders of Group of Eight during their meeting in Saint-Petersburg, discussed and validated the Declaration on counteraction with infectious diseases, reflecting the position of the leaders on the entire complex of problems connected with the spread of infectious diseases, and determining the main principles of the global strategy of counteraction with epidemics under the threats associated with the appearance of new infections, such as avian influenza, HIV-infection/AIDS, tuberculosis, and malaria. While preparing for the Summit, Russia made a range of suggestion aimed mostly on the reinforcement of possibilities to control infectious diseases in Eastern Europe and Central Asia. Practically all Russia's initiatives were supported by the partners, which was also reflected in the conclusive document of the Summit. Following Russian initiatives, Group of Eight intends to increase the effectiveness of international affords on the prevention and elimination of the consequences of natural disasters, including the use of fast response teams. To provide Russia's contribution to this initiative, modernized specialized antiepidemic teams will be used. Taking into consideration the present-day financial participation of Russian Federation in the realization of
Full Text Available Saint Augustine of Hippo often quoted the last verses of the 125th psalm and several times meditated its content in his tractates and sermons. The author of this article examines a selection of these citations, in which the verses are not only quoted but also, both directly and indirectly, commented upon. In his exposition of the Epistle to the Galatians, Augustine merely mentions the fact of the possibility of a spiritual understanding of the passage. The most thorough and most complete exposition of this passage is found in Augustine’s 31st Homily. This exposition is actually more thematic than exegetical. The main points of this homily include the idea of an explanation of the various reasons for tears shed by people during their earthly lives (the tears of martyrs, the tears deriving from earthly pains and sorrows, the tears of a just man separated from his God. But the most profound interpretation of these psalm verses is found in Augustines’s exposition of Psalm 125 (11–13. Here Augustine enumerates all the good actions which he considers to be symbolized by the idea of sowing (almsgiving, aid rendered through deed, aid rendered through word, the mere desire to render aid. At the same time, Augustine does not develop in this exposition the idea of forgiving offences as a type of almsgiving. On the other hand he reveals the essence of good works as charity and the Goal of those who practise good works as the union of the faithful soul with Christ. The author includes a Russian translation of the 31st homily at the end of his article.
Hyžný, Matúš; Gašparič, Rok
Ghost shrimps of the family Callianassidae are very common in the fossil record, but mostly as isolated cheliped elements only. The assignment to biologically defined genera, diagnosed on the basis of soft part morphology, is thus rather difficult. In this respect, proxy characters present on chelipeds that are the most durable ghost shrimp remains are needed to ascribe fossil material to extant genera. The genus Calliax de Saint Laurent, 1973 has been particularly obscure in this respect. Thorough comparison of extant members of the genus resulted in evaluation of characters present on chelipeds being taxonomically important on the genus level, specifically: 1) rectangular major P1 propodus with two ridges on the base of the fixed finger extending onto manus; 2) major P1 fingers relatively short; and 3) minor P1 chela with dactylus longer than fixed finger and possessing a wide gap between fingers. On this basis, Callianassa michelottii A. Milne Edwards, 1860, from the Oligocene and Miocene of Europe is herein reassigned to Calliax. Further re-examination of the ghost shrimp fossil record revealed that C. szobensis Müller, 1984, from the Middle Miocene of Hungary represents the same animal as C. michelottii and they are synomymised herein. The known geographic distribution of C. michelottii is expanded by the first confirmed occurrence of the species in Slovakia. All occurrences of C. michelottii known to date are reviewed and documented. The presence of Calliax michelottii comb. nov. may be considered an indicator of deeper marine settings. Based on the scarce fossil record known to date, Calliax has a Tethyan origin; it supposedly migrated westward to establish present day communities in the Caribbean sometime before the Middle Miocene.
Full Text Available The constellation of pain, resentment, the body, and time – as they exist in the wake of the Enlightenment and in the dawn of a new barbarism - is found throughout the work of Jean Améry and Peter Sloterdijk. Both thinkers were especially influenced by Nietzsche’s readings of resentment, his challenge to the Enlightenment, and his turn to the body as the basis of a new kind of thinking which starts with pain, dwells in irreversible time, and ends with the possibility of action and joy. While this new thinking is novel and appeals to all humankind, the most unexpected points of convergence between Améry and Sloterdijk can be found in their particular neo-Nietzschean articulations of Jewishness: using what Harold Bloom would call revision, they both propose a revision of Nietzsche’s reading of Judaism as resentment. Améry associates Jewishness with “revolt” while Sloterdijk associates what he calls “kynicism” (as opposed to cynicism with Jewishness.1 Intensely aware of the mortal blows that have been dealt to the Enlightenment, philosophy, and modernity as well as to the human body during the Holocaust, Améry and Sloterdijk both address – either directly or indirectly – the meaning of cynicism in relation to Jewishness, in particular, and the modern condition, in general.
Bedikian, Agop Y.; Kim, Kevin B.
Background: Vemurafenib, a selective BRAF inhibitor that has antineoplastic activity in patients with unresectable or metastatic malignant melanoma whose tumor harbors a BRAF V600E mutation, has multiple drug-associated cutaneous adverse effects. Purpose: To provide a detailed and comprehensive review of reported changing or new pigmented lesions in oncology patients who have been treated with vemurafenib. Methods: The new appearance of melanocytic nevi on normal-appearing skin after initiating treatment with vemurafenib is described in two men with metastatic malignant melanoma whose tumors demonstrated a BRAF V600E mutation. Using the PubMed database, an extensive literature search was performed for the following topics: vermurafenib, nevus, nevi, melanoma, pigmented lesion, cutaneous, adverse effect, side effect. The results of the search were used to secure all reports of new or changing pigmented lesions after initiating treatment with vemurafenib. Results: Vemurafenib is associated with both changes in existing pigmented lesions (including involution, alteration of color and size, and progression to melanoma) and the onset of new melanocytic lesions—nevi (in 5 patients) and primary melanomas (in 2 patients). Visual examination, dermoscopic evaluation, and reflectance confocal microscopy have been used to document the changes in existing or new melanocytic lesions subsequent to initiating treatment with vermurafenib. Histopathology analysis has shown these lesions to usually be either dysplastic nevi or new primary melanomas. Conclusion: Vemurafenib-treated patients can develop new pigmented lesions (such as nevi) and/or morphological changes in their existing melanocytic lesions (such as involution, increase in size, or alternation of color). In addition, they can develop new primary malignant melanomas that either occur de novo on normal-appearing skin or develop in pre-existing melanocytic lesions. Therefore, total body skin examination should be
Guadeloupe, F.; de Rooij, V.A.
In this essay we contend that studying the practice of pimping (being pimped and positively pimping the categories with which one is pimped) may be a way for the Caribbean to speak to and assert a universal human condition: the role of sex in human history and human societies. A mighty and
Franklin, Lynn Marie
A secondary analysis of extant data from The Cache County Study on Memory Health and Aging (CCSMHA), this study examines the association between religiosity and new-onset depression between baseline and 4-year follow-up interviews in a sample of 1,439 community-dwelling elderly members of The Church of Jesus Christ of Latter-day Saints (LDS), aged 65 to I 00. Logistic regression models found that church attendance, voluntarism in religious groups, and direct experiences of God occurring more ...
Full Text Available This essay explores the parallel yet opposite stances taken both personally and textually by Perse and Char with respect to drama of World War II. While Perse remained disdainfully aloof from public affairs after the defeat and proclaimed in his poetry his solidarity with all humanity, Char explicitly linked his writing to events, yet sought to create a human space removed from history's upheavals. Striving to transcend the vicissitudes of individual existence, Perse celebrates an epic vision of history that overlooks and even condones its violence. Focusing on the inconsistent, fragmentary nature of existence, Char prevents us from having any teleological delusions concerning war.
Full Text Available This work is focused on the identification of the whole body of a stony epigraphic and figure document, belonging to the town of Trapani. Up to know this document, of the XVII century, has been considered preserved only partly, and for what regards the prominent remaining part, that was the figure part, it was known only thanks to an Eighteenth century transcription endowed with a drawing. On the one hand, regarding the figure plaque, it is shown the monumental complex which it belongs to i.e. the Church of Santa Lucia in Trapani, today fallen into disuse, in relation to the historical evolution of the urban area of Trapani; on the other hand, it is highlightened its historical-social and historical-religious importance, since it expresses the devotions of the fishermen and seamen social classes of Trapani, who asked this document as memorial of a very lucky coral fishing. The epigraphic and figure text allows to read the most deep-rooted faith trends into some definite social classes of the society of the Trapani society, from the end of the Medieval Age till now. This document can be considered as an extraordinary nautical chart about the whole coast of Trapani, as it equipped with correct indicationsabout distances and paths, and geomorphologic and toponymic exact indications.
many distinct solutions and comparisons should we present to a user. To answer this question our research involved exploring graph-theoretic measures...Groups, Open University of Catalonia , Barcelona, Spain, 2008. Transitions Meandre open source license approved. The Meandre infrastructure, an
Jetten, Victor; van Westen, Cees; Ettema, Janneke; van den Bout, Bastian
Disaster Risk Management combines the effects of natural hazards in time and space, with elements at risk, such as ourselves, infrastructure or other elements that have a value in our society. The risk in this case is defined as the sum of potential consequences of one or more hazards and can be expressed as potential damages. Generally, we attempt to reduce risk by better risk management, such as increase of resilience, protection and spatial planning. Caribbean islands are hit by hurricanes and tropical storms with a frequency of 1 to 2 every 10 years, with devastating consequences in terms of flash floods and landslides. The islands basically consist of a central (volcanic) mountain range, with medium and small sized catchments radiating outward towards the ocean. The coastal zone is inhabited, while the ring road network is essential for functioning of the island. An example of a case study is given for the island of Saint Lucia. Recorded rainfall intensities during tropical storms of 12 rainfall stations surpass 200 mm/h, causing immediate flash floods. Very often however, sediment is a forgotten variable in flash flood management: protection and mitigation measures as well as spatial planning all focus on the hydrology, the extent and depth of flood water, and sometimes of flood velocities. With recent developments, the opensource model LISEM includes hydrology and runoff, flooding, and erosion, transport and deposition both in runoff, channel flow and flood waters. We will discuss the practical solutions we implemented in connecting slopes, river channels and floodplains in terms of water and sediment, and the strength and weaknesses we have encountered so far. Catchment analysis shows two main effects: on the one hand in almost all cases upstream flooding serves as a temporary water storage that prevents further damage downstream, while on the other hand, erosion upstream often blocks bridges and decreases channel storage downstream, which increases the
Wallace, Beth; Kafaja, Suzanne; Furst, Daniel E; Berrocal, Veronica J; Merkel, Peter A; Seibold, James R; Mayes, Maureen D; Khanna, Dinesh
Dyspnoea is a common, multifactorial source of functional impairment among patients with dcSSc. Our objective was to assess the reliability, construct validity and responsiveness to change of the Saint George's Respiratory Questionnaire (SGRQ) in patients with early dcSSc participating in a multicentre prospective study. At enrolment and 1 year, patients completed the SGRQ (a multi-item instrument with four scales: symptoms, activity, impact and total), a visual analogue scale (VAS) for breathing and the HAQ Disability Index (HAQ-DI) and underwent 6 min walk distance and pulmonary function tests, physician and patient global health assessments and high-resolution CT (HRCT). We assessed internal consistency reliability using Cronbach's α. For validity we examined the ability of the SGRQ to differentiate the presence vs absence of interstitial lung disease (ILD) on HRCT or restrictive lung disease and evaluated the 1 year responsiveness to change using pulmonary function tests and patient- and physician-reported anchors. Correlation coefficients of 0.24-0.36 were considered moderate and >0.37 was considered large. A total of 177 patients were evaluated. Reliability was satisfactory for all SGRQ scales (0.70-0.93). All scales showed large correlations with the VAS for breathing and diffusing capacity of the lung for carbon monoxide in the overall cohort and in the subgroup with ILD. Three of the four scales in the overall cohort and the total scale in the ILD subgroup showed moderate to large correlation with the HAQ-DI and the predicted forced vital capacity (r = 0.33-0.44). Each scale discriminated between the presence and absence of ILD and restrictive lung disease (P ≤ 0.0001-0.03). At follow-up, all scales were responsive to change using different anchors. The SGRQ has acceptable reliability, construct validity and responsiveness to change for use in a dcSSc population and differentiates between patients with and without ILD. © The Author 2015. Published by
A. M. Biblin
Full Text Available The purpose of the study was to examine the quantity and quality of publications on radiation safety of the population in the media on the example of Saint Petersburg and the Leningrad region for the period of the first three-quarters of 2016. An analysis of publications in the media is an essential part of the work on the formation of an adequate perception of the radiation risk by the population. The Information and Analytical Centre of Rospotrebnadzor on radiation safety of the population developed a pilot computer-assisted system for the media publication analysis. The study was performed by this system as a development and improvement of the Center’s works applicable to the registration, storage, and analysis of qualitative and quantitative information contained in the publications. The author selected 27 mass-media sources for analysis: 8 newspapers (2 of them are located in Sosnoviy Bor; 8 TV-channels (4 – federal, 2 – regional, 2 – local in Sosnoviy Bor; 10 online media and the web-site of the Sosnoviy Bor administration. During the analyzed period, 1075 informational materials on issues of radiation safety were collected and added to the database. The largest number of publications were in the second quarter of 2016. The peak of publication activity on issues of radiation safety was registered in April. This fact is related to the 30th anniversary of the Chernobyl accident. A significant part (over 50% of the publications were neutral in all media and in different types of media. A significant part of the publications is a brief informational note with the neutral nature of the character of the information. The number of materials with negative character of information among the publications on the subject of “radioactive waste” is more than 2 times larger than that for the publications on the subject of “nuclear energy”. The majority of publications belongs to the information genre. Analytical materials are a minor part
Nyblade, Laura; Jain, Aparna; Benkirane, Manal; Li, Li; Lohiniva, Anna-Leena; McLean, Roger; Turan, Janet M; Varas-Díaz, Nelson; Cintrón-Bou, Francheska; Guan, Jihui; Kwena, Zachary; Thomas, Wendell
Within healthcare settings, HIV-related stigma is a recognized barrier to access of HIV prevention and treatment services and yet, few efforts have been made to scale-up stigma reduction programs in service delivery. This is in part due to the lack of a brief, simple, standardized tool for measuring stigma among all levels of health facility staff that works across diverse HIV prevalence, language and healthcare settings. In response, an international consortium led by the Health Policy Project, has developed and field tested a stigma measurement tool for use with health facility staff. Experts participated in a content-development workshop to review an item pool of existing measures, identify gaps and prioritize questions. The resulting questionnaire was field tested in six diverse sites (China, Dominica, Egypt, Kenya, Puerto Rico and St. Christopher & Nevis). Respondents included clinical and non-clinical staff. Questionnaires were self- or interviewer-administered. Analysis of item performance across sites examined both psychometric properties and contextual issues. The key outcome of the process was a substantially reduced questionnaire. Eighteen core questions measure three programmatically actionable drivers of stigma within health facilities (worry about HIV transmission, attitudes towards people living with HIV (PLHIV), and health facility environment, including policies), and enacted stigma. The questionnaire also includes one short scale for attitudes towards PLHIV (5-item scale, α=0.78). Stigma-reduction programmes in healthcare facilities are urgently needed to improve the quality of care provided, uphold the human right to healthcare, increase access to health services, and maximize investments in HIV prevention and treatment. This brief, standardized tool will facilitate inclusion of stigma measurement in research studies and in routine facility data collection, allowing for the monitoring of stigma within healthcare facilities and evaluation of
Nyblade, Laura; Jain, Aparna; Benkirane, Manal; Li, Li; Lohiniva, Anna-Leena; McLean, Roger; Turan, Janet M; Varas-Díaz, Nelson; Cintrón-Bou, Francheska; Guan, Jihui; Kwena, Zachary; Thomas, Wendell
Introduction Within healthcare settings, HIV-related stigma is a recognized barrier to access of HIV prevention and treatment services and yet, few efforts have been made to scale-up stigma reduction programs in service delivery. This is in part due to the lack of a brief, simple, standardized tool for measuring stigma among all levels of health facility staff that works across diverse HIV prevalence, language and healthcare settings. In response, an international consortium led by the Health Policy Project, has developed and field tested a stigma measurement tool for use with health facility staff. Methods Experts participated in a content-development workshop to review an item pool of existing measures, identify gaps and prioritize questions. The resulting questionnaire was field tested in six diverse sites (China, Dominica, Egypt, Kenya, Puerto Rico and St. Christopher & Nevis). Respondents included clinical and non-clinical staff. Questionnaires were self- or interviewer-administered. Analysis of item performance across sites examined both psychometric properties and contextual issues. Results The key outcome of the process was a substantially reduced questionnaire. Eighteen core questions measure three programmatically actionable drivers of stigma within health facilities (worry about HIV transmission, attitudes towards people living with HIV (PLHIV), and health facility environment, including policies), and enacted stigma. The questionnaire also includes one short scale for attitudes towards PLHIV (5-item scale, α = 0.78). Conclusions Stigma-reduction programmes in healthcare facilities are urgently needed to improve the quality of care provided, uphold the human right to healthcare, increase access to health services, and maximize investments in HIV prevention and treatment. This brief, standardized tool will facilitate inclusion of stigma measurement in research studies and in routine facility data collection, allowing for the monitoring of stigma within
Serfaty, D; Dreyfus, R; Chemama, D
A 1985 prospective study at the Saint-Louis Hospital in Paris indicated that 138 of 252 abortions (53.8%), were associated with problems of contraception and 114 were not. The percentages of cases involving problems with contraception varied from 34% to 58.2% according to the physicians participating in the study. Despite the very subjective nature of the estimates, at least 1/3 of abortions at this hospital are associated with difficulties in contraception. In 64 of 138 cases, the problems were caused by psychological factors, including ambivalent desire for pregnancy in 24 cases, psychological refusal of contraception in 15 cases, psychological immaturity in 4 cases, various psychological problems in 4 cases, and a psychological factor associated with some other difficulty in 17 cases. Among the various psychological problems were 1 woman using abortion as a contraceptive method who had undergone 9 abortions and 1 case of cultural resistance to contraception. Among the 17 cases where the psychological problem was associated with some other difficulty there were 7 cases of ambivalent desire for pregnancy, 4 cases of psychological refusal of contraception, and 6 cases of various psychological problems. Among these cases, available contraceptive methods were contraindicated or poorly tolerated apart from the psychological difficulty. Among the 74 cases of contraceptive difficulty not associated with psychological factors were: 12 cases of nulliparity and nontoleration of combined oral contraceptives (OCs); 22 cases of nulliparity and OCs contraindicated or inadvisable; 22 cases of OCs and IUDs contraindicated, inadvisable, or refused; 5 cases of IUD failure with OCs not possible; 2 cases of failure of local methods with other methods not possible; and 11 cases of various difficulties including 4 of difficulties of communication for linguistic reasons and 7 cases of repeated forgetting or incorrect taking of pills. It is not known whether the 252 cases in this survey
Optical Nutrients product 14772 which consists of flowering tops and leaves and is standardized to 0.3% hypericin. Other ingredients include maltodextrin...Nutrients (Foster City, CA) product #14772. The preparation contains St. John’s wort flowers and tops (Hypericum perforatum) extract, standardized to 0.3...cycle of chemotherapy, typically 3 or 4 weeks. Serum was collected before the first and second cycles of chemotherapy and cryopreserved in the dark
Neiva Kampff Garcia
Full Text Available Mia Couto in the novel O outro pé da sereia formalizes an encounter of imaginaries (European and African through a temporal progression and a process of constitution of identities which goes beyond the differences and geographical distances. The writer diverts his gaze towards the complexity of human relations, both under an individual approach and a collective one, and in a narrative parallelism, makes it possible for the voices to manifest themselves in the contemporary history to emerge from the historical colonial past and widen their scope in the experiences of modernity. From the position of a borderlike being between the Portuguese and Mozambican cultures, Couto lets his characters wander freely between times, genders and social roles, capturing them in multiple diversions which are so coherent with the constitution of the social actors in modernity. The thought and the voice of the colonial Portuguese culture of the 16th century and the identitary construction of the Mozambican society in the 21st century are revisited in a literary way by the optics of opposition and/or integration, as well as by movements of fragmentation and/or re-composition. The fictional cartography of the work allows an insertion in the discussions of post-modernity and post-colonialism, perspectives under which I reflect when analyzing some narrative niches of the aforesaid novel.
Full Text Available The article concerns the renovation and modernization of two London railway stations - St. Pancras and King‘s Cross. Both stations were built in the middle of the nineteenth century and are an example of industrial heritage. A characteristic feature that distinguishes the two buildings is the metal (iron structure with a glass canopy. The St. Pancras railway station was characterized by a hall with the largest span in the world, and today is one of the leading examples of using iron in the development of architecture and building structures. Both stations have experienced periods of flourishing and stagnation throughout their history. There were even plans to demolish the old stations and build new facilities and in their place. Now, after the successful modernization of St. Pancras and King’s Cross railway stations, they serve as good examples of the adaptation of transport utilities to modern needs, while respecting their historic structure. The problems that the designers and contractors were faced with during the renovation and modernization of the two London stations also deserve attention.
The solar heating and hot water system installed at the William Tao & Associates, Inc., office building in St. Louis, Missouri is described, including maintenance and construction problems, final drawings, system requirements, and manufacturer's component data. The solar system was designed to provide 50 percent of the hot water requirements and 45 percent of the space heating needs for a 900 sq ft office space and drafting room. The solar facility has 252 sq ft of glass tube concentrator collectors and a 1000 gallon steel storage tank buried below a concrete slab floor. Freeze protection is provided by a propylene glycol/water mixture in the collector loop. The collectors are roof mounted on a variable tilt array which is adjusted seasonally and is connected to the solar thermal storage tank by a tube-in-shell heat exchanger. Incoming city water is preheated through the solar energy thermal storage tank.
The solar heating and hot water system installed at the William Tao & Associates, Inc., office building in St. Louis, Missouri is described, including maintenance and construction problems, final drawings, system requirements, and manufacturer's component data. The solar system was designed to provide 50 percent of the hot water requirements and 45 percent of the space heating needs for a 900 sq ft office space and drafting room. The solar facility has 252 sq ft of glass tube concentrator collectors and a 1000 gallon steel storage tank buried below a concrete slab floor. Freeze protection is provided by a propylene glycol/water mixture in the collector loop. The collectors are roof mounted on a variable tilt array which is adjusted seasonally and is connected to the solar thermal storage tank by a tube-in-shell heat exchanger. Incoming city water is preheated through the solar energy thermal storage tank.
Full Text Available A very important factor and with direct implications in the process of development of the existing tourism potential is the marketing activities related to the promotion of tourist offer both domestically and internationally. Knowledge from direct source of the opinions of managers and directors of the most important tourist locations providing tourism services - hotels and hostels - imposed the achievement of a qualitative marketing research. The qualitative research was conducted in Sfântu Gheorghe. This paper contains the vertical and horizontal analysis of the eight subjects interviewed. The qualitative marketing research aims at knowing the opinions of managers of hotels and hostels in Sfântu Gheorghe on their promotional activity over time in the future.
In his lecture, Dr. Francaviglia presents a fascinating framework in which to understand American history and culture, as well as Mormons specifically. Orientalism was defined for the lecture as the assimilation or imitation of that which is oriental in religious or philosophical thought, or in art. Through various mediums, including architectural examples, quotes from Mormons and their detractors, and travel literature, Dr. Francaviglia demonstrates that not only Mormons were compared to Ori...
Eissler, K R
It is common to base an assessment of psychological health on an individual's ability to love. However, the ability to hate is no less important a manifestation of the healthy personality. The author investigates the psychology of hatred and the possible effects of psychoanalytic treatment on the development of the capacity to hate and, by extension, to engage in revolutionary political activity.
... 1999, and implemented a full network of air quality monitors by January 2001. On January 5, 2005, in... EPA for further consideration. See American Farm Bureau Federation and National Pork Producers Council... impose substantial direct costs on Tribal governments or preempt Tribal law. List of Subjects in 40 CFR...
22.214.171.124 Hunting 20 126.96.36.199 Endangered Species 21 2.2.4 PEST SPECIES 21 188.8.131.52 Insects 21 184.108.40.206 Arachnids 22 220.127.116.11 Rodents 22 2.3 SOCIO-CULTURA...and the presence of standing water. 18.104.22.168 Arachnids Two tick-vectored diseases, tularemia and Rocky Mountain spotted fever are known from this area
E. V. Sharipova; I. V. Babachenko; Yu. I. Sichkovskaja; Yu. Yu. Chernyshova
The paper studies the clinical and epidemiological features of one of the acute clinical forms of infection caused by the human herpes virus type 6 — «sudden exanthema » — in children of St. Petersburg. The study involved 149 children hospitalized aged 6 months to 15 years in the period from 2012 to 2014. Sudden rash confirmed by molecular genetic studies in 38 children. The disease is mainly observed in patients of the first two years of life. Rash and toxic syndromes dominated in clinical p...
E. V. Sharipova
Full Text Available The paper studies the clinical and epidemiological features of one of the acute clinical forms of infection caused by the human herpes virus type 6 — «sudden exanthema » — in children of St. Petersburg. The study involved 149 children hospitalized aged 6 months to 15 years in the period from 2012 to 2014. Sudden rash confirmed by molecular genetic studies in 38 children. The disease is mainly observed in patients of the first two years of life. Rash and toxic syndromes dominated in clinical picture.
Moritz, Steffen; Wahl, Karina; Ertle, Andrea; Jelinek, Lena; Hauschildt, Marit; Klinge, Ruth; Hand, Iver
Inflated responsibility is ascribed a pivotal role in the pathogenesis of obsessive-compulsive disorder (OCD). The aim of the study was to assess interpersonal attitudes and behaviors contributing to enhanced responsibility in OCD. In particular, we tested the hypothesis that individuals diagnosed with OCD share stronger latent aggression toward…
L. V. Lyalina
Full Text Available Abstract. Analysis of anogenital warts morbidity in St. Petersburg and Russian Federation in 2000–2013 has been carried out. The incidence rate in the population of St. Petersburg during the observation period was found to be 1.4–2.3 times higher. In 2011–2013, 3310 pregnant women were tested for high carcinogenic risk HPV by PCR. Prevalence rate of HPV genotype 16 was 11.0 per 100 tested persons. Other genotypes (31, 52, 33, 45, 58, 39, 18, 59, 35were determined less often (p < 0.001 6.3; 6.3; 5.1; 4.02; 3.7; 3.4; 2.9; 2.8 and 2.7 per 100 persons, respectively. An increased morbidity of cervical cancer in women aging from 25 to 49 years old was established. Assessment of the economic burden of diseases associated with HPV has shown that in 2012 in St. Petersburg expenses were more than one billion rubles. In the structure of economic lost the largest proportion was associated with premature mortality of women with cervical cancer.
Full Text Available World Health Organization has recommended all countries to introduction of Pneumococcal Conjugate Vaccine (PCV in routine immunization schedule, especially those countries with higher rate of mortality in children. However, Islamic Republic of Iran and more than 50 other countries including Algeria, Antigua and Barbuda, Belarus, Belize, Bhutan, Bosnia and Herzegovina, Brunei Darussalam, Cabo Verde, Chad, China, Comoros, Cook Islands, Croatia, Cuba, Czech Republic, Democratic People's Republic of Korea, Dominica, Egypt, Equatorial Guinea, Estonia, Gabon, Grenada, Guinea, Haiti, India, Jamaica, Jordan, Malaysia, Maldives, Malta, Montenegro, Nauru, Poland, Romania, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines, Samoa, San Marino, Serbia, Seychelles, Slovenia, Somalia, South Sudan, Sri Lanka, Syrian Arab Republic, Tajikistan, Thailand, The former Yugoslav Republic of Macedonia, Timor-Leste, Tonga, Tunisia, Turkmenistan, Tuvalu, Ukraine, Vanuatu, and Viet Namhave not introduced PCV till April 2016.
Little is known of clinical toxoplasmosis in humans and animals in the Caribbean countries. We investigated the prevalence of IgG and IgMantibodies in 437 pregnant women from 10 English speaking Caribbean countries. Antibodies (IgG) to T. gondii (modified agglutination test, MAT, cut-off 1:6) were f...
Bonev, Boncho; Gibb, E. L.; Brewer, G.; Novak, R.; Mandell, A. M.; Seaton, P.; Price, J.; Long, T.; Bahar, S.; Edwards, S. S.
Developing a full-year program to support secondary and middle school science education is a key part of the "broader impact” component of NSF Grant AST- 0807939 (PI/Co-PI Bonev/Gibb). This program is realized at two stages: (1) a professional development course for teachers is offered during the summer; (2) during the subsequent academic year we collaborate with educators in lessons planning or curriculum development as demanded in their particular schools. We successfully offered the course “ Comets, Origins, and Life: Interdisciplinary Science in the Secondary Classroom ” (45 contact hours; 3 credits) in the summers of 2009 and 2010 at the Catholic University of America. This class demonstrates how a complex hypothesis - for the delivery of water and prebiotic organic matter to early Earth - is being tested by integrating astronomy, physics, chemistry, biology, and Earth and planetary science. Collaborations with participants from the 2009 class include curriculum development within the Earth Science program in Prince Georges county, MD and strengthening science in Washington DC public schools. Our next step is to offer our class in the Saint Louis, MO area. The main challenge in our work with educators is not to present them with "interesting information", but to fit what we offer within the very particular curriculum expectations of their school districts. These curriculum expectations often vary from district to district and sometimes from year to year. We gratefully acknowledge the support by the NSF, allowing to fully integrate our research area into education. We also gratefully acknowledge our collaborations with the Goddard Center for Astrobiology and the Howard B. Owens Science Center (both in MD) in developing our class curriculum. Educators interested in this program can contact Boncho Bonev (email@example.com; for the Washington DC and Baltimore, MD areas) and Erika Gibb (firstname.lastname@example.org; for the Saint Louis, MO area).
The Technical Department of the Conseil général de l'Ain has informed CERN of forthcoming work to make the Saint-Genis Pouilly roundabout (junction of the D35 and D984) safer for cyclists. The work will include, in particular, the installation of lane dividers between the cycle track and the road, improved road markings and the erection of additional road signs. The overall layout of the junction will not be affected. Relations with the Host States Service Tel.: 72848 email@example.com www.cern.ch/relations
Full Text Available In the eighteenth century, confraternities such as that of Our Lady of the Rosary and those dedicated to the black saints Benedict, Iphigenia and Elesban – to mention only the most popular devotions – were common in different areas of the Atlantic World. They were especially popular among people of color, both enslaved and free. In this paper I argue that the popularity of these sodalities should not be understood solely as the result of Catholic expansion. Rather, Africans and their descendents assumed an active role in this process, as important agents in propagating and popularizing the devotions and black confraternities. In order to understand this process I examine the history of black confraternities and devotions in two parts of the Portuguese Atlantic world: the kingdom of Portugal and the territories it conquered in Angola.
Sandell, Elizabeth J., Ed.
This report describes the initial plan, participants, and evaluation of Saint Paul (Minnesota) Children's Initiative (SPCI) during 1993. The SPCI is a family-community program to improve child health, child development, school performance, and to enhance family functioning through formal and informal support systems in Saint Paul/Ramsey county. At…
Durán Vázquez, José Francisco
Full Text Available The present article must like main objective interrogate itself on the sense that has the present representations of the work in the context of the productive scene of the take-modern societies of market. The analysis that sets out here interprets these representations in relation to the work of Émile Durkheim and Saint-Simon, being two of the main authors who have more contributed to forge the ideological formation of the societies of the work, like an attempt of update of the symbolic structure of these societies, in order that it continues maintaining all its integrating and legitimate load in relation to the new productive and labour realities
Michalova, Kvetoslava; Kazakov, Dmitry V; Michal, Michael; Hadravsky, Ladislav; Kacerovska, Denisa; Rychly, Boris; Miesbauerova, Marketa; Michal, Michal
Differentiated squamous intraepithelial lesion (dSIL) is morphologically and immunohistochemically analogous in the whole anogenital region. dSIL is a premalignant lesion frequently misinterpreted histopathologically as a benign dermatosis. The authors describe a peculiar change in the basal cell layer of the epidermis/epithelium overlying anogenital melanocytic nevi that may histopathologically imitate dSIL. The aim of this study is to familiarize the pathologists with this pitfall to avoid its possible overdiagnosis as dysplasia. Further, we tried to explore the biological characteristics of the dSIL-like changes and to focus on the differential diagnostic aspects. Seventy cases of anogenital nevi were retrieved from our registry. All cases were stained with hematoxylin and eosin (H&E) and reviewed. Cases in which the epidermis overlying nevi featured atypical appearing basal keratinocytes in otherwise fully differentiated epithelium, variable degrees of acanthosis and parakeratosis were selected for additional investigation. Thirty cases meeting the above described criteria were identified. The patients were 8 males and 22 females, with age at the time of diagnosis ranging from 4 to 68years. Follow-up data were available for 28 patients (range 0.5-19years, mean 5.1), and to date, no signs of epithelial malignancy have been recorded. Immunohistochemically (IHC), the epidermis overlying nevi showed insignificant positivity for p53 in all tested cases. Melanocytic markers (S-100 protein, SOX10, Melan A) and cytokeratin AE1/3 labeled melanocytes and keratinocytes, respectively, enabling their distinction, especially in nevi featuring a junctional component. Differentiated squamous intraepithelial lesion-like changes seem to occur relatively often in the epidermis overlying anogenital melanocytic nevi. Since morphologically they are virtually identical to the "true" dSIL, their distinction largely depends on p53 expression in basal keratinocytes with normal p53
Inhibition of Corneal Neovascularization with the Combination of Bevacizumab and Plasmid Pigment Epithelium-Derived Factor-Synthetic Amphiphile INTeraction-18 (p-PEDF-SAINT-18 Vector in a Rat Corneal Experimental Angiogenesis Model
Full Text Available Bevacizumab, a 149-kDa protein, is a recombinant humanized monoclonal antibody to VEGF. PEDF, a 50-kDa glycoprotein, has demonstrated anti-vasopermeability properties. In this study, we demonstrated that the combination of bevacizumab and plasmid pigment epithelium-derived factor-synthetic amphiphile INTeraction-18 (p-PEDF-SAINT-18 has a favorable antiangiogenic effect on corneal NV. Four groups (Group A: 0 μg + 0 μg, B: 0.1 μg + 0.1 μg, C: 1 μg + 1 μg, and D: 10 μg + 10 μg of bevacizumab + p-PEDF-SAINT-18 were prepared and implanted into the rat subconjunctival substantia propria 1.5 mm from the limbus on the temporal side. Then, 1 μg of p-bFGF-SAINT-18 was prepared and implanted into the rat corneal stroma 1.5 mm from the limbus on the same side. The inhibition of NV was observed and quantified from days 1 to 60. Biomicroscopic examination, western blot analysis and immunohistochemistry were used to analyze the 18-kDa bFGF, 50-kDa PEDF and VEGF protein expression. No inhibition activity for normal limbal vessels was noted. Subconjunctival injection with the combination of bevacizumab and p-PEDF-SAINT-18 successfully inhibited corneal NV. The bFGF and PEDF genes were successfully expressed as shown by western blot analysis, and a mild immune response to HLA-DR was shown by immunohistochemistry. We concluded that the combination of bevacizumab and p-PEDF-SAINT-18 may have more potent and prolonged antiangiogenic effects, making it possible to reduce the frequency of subconjunctival.Bevacizumab, a 149-kDa protein, is a recombinant humanized monoclonalantibody to VEGF. PEDF, a 50-kDa glycoprotein, has demonstrated anti-vasopermeabilityproperties. In this study, we demonstrated that the combination of bevacizumaband plasmid pigment epithelium-derived factor-synthetic amphiphile INTeraction-18(p-PEDF-SAINT-18 has a favorable antiangiogenic effect on corneal NV. Four groups(Group A: 0 μg + 0 μg, B: 0.1 μg + 0.1 μg, C: 1 μg + 1 μg, and
Study to evaluate the feasibility of soil washing and bioslurry reactor treatability in remediating soils at the Department of Transport site in Saint John to meet site soil cleanup standards. Elements of interest in the soils include cadmium, copper, lead, zinc, and the polychlorinated biphenyls (PCBs). The study reviewed the methods to remove the metals and PCBs. The investigation consisted of a series of screening tests and a series of final tests. The study also involved assessment of bioslurry reactor treatments. The treatability study evaluated the bioslurry reactor technology under five different operational conditions to identify the optimum environment for the biological degradation of PCBs. This report presents the findings from the treatability studies.
Heyrman, Jeroen; Balcaen, An; De Vos, Paul; Swings, Jean
A group of seven halophilic strains (optimal growth at 2.5-10.0% NaCl) was isolated from samples of a wall and a mural painting, both heavily contaminated by microbial growth, inside the Saint-Catherine chapel of Castle Herberstein (Austria). The strains were subjected to a polyphasic taxonomic study that included DNA-DNA relatedness studies, DNA base-ratio determinations, 16S rDNA sequence analysis, rep-PCR genomic fingerprinting, fatty acid analysis and phenotypic and biochemical characterization. The data obtained indicate that the strains belong to the genus Halomonas and represent a novel species, for which the name Halomonas muralis sp. nov. is proposed. The type strain is strain LMG 20969(T) ( = DSM 14789(T)).
An exploration of the Antinous myth in early modern Danish homosexual literature and drama around 1800, including interpretations of two forgotten dramas: "Hadrian" by Konrad Simonsen and "Antinous" by Palle Rosenkrantz.......An exploration of the Antinous myth in early modern Danish homosexual literature and drama around 1800, including interpretations of two forgotten dramas: "Hadrian" by Konrad Simonsen and "Antinous" by Palle Rosenkrantz....
A frican slave),geology and other topics in `naturalhis- tory' (basically all the sciences, but particularly those to do w ith biology and geology). A fter the fam ous voyage on H M S B eagle, D arw in ..... h a n d , sex u a l selectio n , th e stru g g le fo r ex isten ce a n d b io - geographic distribution are positive hypotheses, w hile.
Full Text Available The Moscow scandal concerning Southern Butovo leads to a certain “divide” between the different stages of development in our civil society. The new Housing Code, which maintenance is directly associated with the fussing around high-density development and land relations in the cities, has been a final document in the complex of regulations – the Civil Code, the Land Code, the Town Planning Code etc. These documents have defined the legal space to master. Then our cities will become property of the citizens, but not of the elite representatives, officials and deputies delegated to the governing bodies. In his interview for “New Peterburg” newspaper (2006 Vladimir Pavlov expressed his thoughts about the matters of property and the owners, the land use and the authorities. He thinks that the real estates and their owners need a new system of relations between each other.
Woltsche, Nora; Schmid-Zalaudek, Karin; Deinlein, Teresa; Rammel, Katrin; Hofmann-Wellenhof, Rainer; Zalaudek, Iris
The broad universe of "melanocytic nevi" includes a variety of different subtypes, which can be classified either due to their morphology, epidemiology, genetic alterations or risk for developing melanoma. Regarding morphology, on the one hand macroscopic/clinical and on the other hand histopathological appearance were used to subdivide in the past, often resulting in confusion and poor interobserver agreement, while nowadays dermoscopy presents the clinician's precious bridge between naked-eye examination and histopathological diagnostics, allowing prediction of the lesions' histopathology, follow up and monitoring over time without need of excision. The non-invasive dermoscopic examination relies on the assessment of colors, patterns and the distribution of both within a cutaneous lesion. Until today, the correspondence of certain dermoscopic colors and patterns to certain histopathological correlates has been reported for a huge amount of different cutaneous lesions. Moreover, the correspondence of certain dermoscopic features to certain body sites, age groups and pigmentary traits, but also to specific genetic alterations in lesions, has been broadly investigated. Dermoscopy has led us to a new understanding of melanocytic nevi's biology and evolution and, last but not least, to a new classification system, which we want to present herein. © 2017 Japanese Dermatological Association.
Clarke, Loren E; Flake, Darl D; Busam, Klaus; Cockerell, Clay; Helm, Klaus; McNiff, Jennifer; Reed, Jon; Tschen, Jaime; Kim, Jinah; Barnhill, Raymond; Elenitsas, Rosalie; Prieto, Victor G; Nelson, Jonathan; Kimbrell, Hillary; Kolquist, Kathryn A; Brown, Krystal L; Warf, M Bryan; Roa, Benjamin B; Wenstrup, Richard J
Recently, a 23-gene signature was developed to produce a melanoma diagnostic score capable of differentiating malignant and benign melanocytic lesions. The primary objective of this study was to independently assess the ability of the gene signature to differentiate melanoma from benign nevi in clinically relevant lesions. A set of 1400 melanocytic lesions was selected from samples prospectively submitted for gene expression testing at a clinical laboratory. Each sample was tested and subjected to an independent histopathologic evaluation by 3 experienced dermatopathologists. A primary diagnosis (benign or malignant) was assigned to each sample, and diagnostic concordance among the 3 dermatopathologists was required for inclusion in analyses. The sensitivity and specificity of the score in differentiating benign and malignant melanocytic lesions were calculated to assess the association between the score and the pathologic diagnosis. The gene expression signature differentiated benign nevi from malignant melanoma with a sensitivity of 91.5% and a specificity of 92.5%. These results reflect the performance of the gene signature in a diverse array of samples encountered in routine clinical practice. Cancer 2017;123:617-628. © 2016 American Cancer Society. © 2016 Myriad Genetics, Inc. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society.
Comfere, Nneka I; Chakraborty, Rima; Peters, Margot S
Dermatopathology reports influence clinical management, but it is not clear to what extent comments on margin involvement of histopathologically dysplastic nevi (HDN) influence decisions about re-excision or complete excision. We sought to determine if standardized margin comments (MCs) on HDN influence re-excision rates. By reviewing medical records, we compared re-excision rates of HDN reported with (May 2011 to December 2012) and without (January 2007 to December 2010) standardized MCs, and surveyed clinicians to assess perceptions of the impact of MCs on their management of HDN. Of 584 HDN, 302 had MCs and 282 did not. Re-excision was recommended or performed at a significantly higher rate for patients in the group without MCs (51.8%, 146 of 282) than in the MC group (39.4%, 119 of 302); P = .003 regardless of margin status. This difference was observed among HDN diagnosed as mildly and moderately dysplastic but not for severely dysplastic nevi. In all, 40% (16 of 40) of clinicians responded that they are more likely to biopsy pigmented lesions with a clinical margin of normal-appearing skin than they were before MCs were routinely included in dermatopathology reports. This was a retrospective study. Re-excision rates were significantly lower in patients who had HDN reported with standardized MCs. MCs may help reduce re-excision rates, with associated reduction in health care use, cost, and morbidity. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Ohmaru, Youkou; Ohmaru, Koichi; Koga, Noriyuki; Migita, Hisashi; Kiyokawa, Kensuke
A small mass of melanocytic nevi on the face is commonly treated by surgical resection. This method is associated with cosmetic complications, such as scarring and scar contracture. The use of CO2 Laser treatment to avoid these complications is increasing. However, scarring or recurrence may still occur after CO2 Laser treatment. To resolve these problems, we developed a new Combined Laser Therapy (CLT) protocol using three laser instruments. We used CO2 Laser, Nd:YAG Laser and Q-Switched Ruby Laser. The first treatment was a minimal mass reduction using CO2 Laser. The surface is covered with carbonized tissue. The second treatment with Nd:YAG Laser which removes the carbonized tissue, because the laser specifically absorbs black chromatophores. Finally, any surviving nevus cells containing melanin are destroyed with Q-Switched Ruby Laser. This method was used for 12 cases presenting with small masses of melanocytic nevi on the face. The maximum size of the mass was 20 mm. All cases resulted in a cosmetic improvement and there was no scarring or recurrence. Either satisfactory or greatly improved cosmetic results were obtained in all cases. We think that the wound healing without scarring observed in all of our cases is related to the administration of both CLT and auto-simultaneous Low reactive Level Laser Therapy (LLLT) in these cases. Therefore, this method may provide the better treatment than surgical resection in the future.
Fleming, Nathaniel H; Egbert, Barbara M; Kim, Jinah; Swetter, Susan M
Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN). To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins. Retrospective cohort study of mixed referral and community patients from an academic pigmented lesion clinic and dermatology clinics of the affiliated Veteran Affairs medical center with biopsy-confirmed DN with positive histologic margins diagnosed from May 15, 1991, to July 8, 2015, and followed up through May 30, 2016. A consecutive sample of 1473 histologically confirmed DN was identified using surgical pathology databases at the study sites; 590 cases in 498 patients met eligibility criteria. The primary outcome was the proportion of biopsied DN that progressed to histologically confirmed invasive or in situ melanoma. Secondary outcomes included local nevus recurrence and development of primary melanoma at other anatomic sites. The 498 patients had a mean (range) age of 57.6 (14-93) years and 90% were male. Among 590 positive-margin DN, 191 were reexcised and 399 clinically observed without further surgery; 170 reexcised and 304 observed DN had available follow-up data, with mean (SD) follow-up of 5.5 (4.6) years. Cases in the observation group were more likely to demonstrate nevus recurrence than those that were reexcised (3.3% vs 0%; P = .02). Six of 304 (2.0%) observed DN subsequently developed melanoma at the same site, compared with 1 of 170 (0.06%) that were reexcised (P = .43). Five of 6 observed patients who developed melanoma initially underwent partial biopsy with grossly positive margins; 1 melanoma in situ evolved from an excisionally biopsied moderately dysplastic nevus 5 years later. Only 1 case of thin invasive melanoma (≤1 mm) was observed, and no deaths from melanoma arising from biopsy-proven DN occurred through the
The present study represents a synthesis of Saint Gregory Palamas's teaching on the vision of Divine Light as it was articulated in the debate with his adversaries. Directly linked to this topic are other adjacent issues, namely the Transfiguration of Christ, the intellectual and the mystical knowledge, the nature of the divine ...
Potter, David Charles [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Taylor, Craig Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Coons, James Elmer [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
The percent void of the Fort Saint Vrain (FSV) material is estimated to be 21.1% based on the volume of the gap at the top of the drums, the volume of the coolant channels in the FSV fuel element, and the volume of the fuel handling channel in the FSV fuel element.
Krylova Severina Vyacheslavovna
Full Text Available This article shows the interdependences of territorial distribution of temples and their architectural-spatial and compositional features in St. Petersburg and the counties. The author revealed two different approaches to temple arrangement depending on the type of environment - in urban areas and rural areas. The construction of a temple in St. Petersburg was strictly regulated: its space-planning solution, accommodation, the place assigned for parish church, etc. The article draws attention to the particular choice of solutions, removal of land for construction, and certain architectural features of the temples. The author generally distinguishes four types of space-planning decisions of religious buildings: hall multiplex (The Basilica in the form of a Latin cross, centric (cross dome as the most common types of churches, combined. In turn, these types of temples were correlated with various types of accommodation identified by the author. Spatial distribution of temples include: a the location of temples in the natural landscape system and b with respect to the location of the man-made temples' environment (historical and cultural, in correlation with the buildings and / or communications (land and water communications, c the formation of a spatially-visual network (system of the city and surrounding area. For a better understanding of the revealed dependences chronological phase analysis was used, since the time prior to Saint Petersburg construction and till 1850. The periodization of temple architecture development during 1703-1850 was identified. The period before Saint Petersburg was also considered, though less detailed. The stages are minimal chronological segments, within which settlement system was unified by spatial and social characteristics, as well as uniform rules of specific territorial, economic and social development. As chronological boundaries, specific dates of the events were identified, which determined the transition
Ion Marian CROITORU
Full Text Available While, in the 19th century, many servants of the monastic settlements left Wallachia and Moldova, because of the measures taken there, the situation was nevertheless different in the 18th century, when monks from different areas inhabited by Orthodox Christians came to the Romanian Countries, where they encountered an uninterrupted reality of hesychastic renewal started by Saint Gregory of Sinai (1255-1346, due to the fact that the Romanians had known another cultural continuity, different from what had happened, until that century, in the Greek Byzantine or in the Slav world. This reality explains why the revitalization of the hesychastic and spiritual life in the areas north of the Danube is related, in the 18th century, to the Saints Basil of Poiana Mărului (1692-1767 and Paisius Velichkovsky or Wieliczkowski of Neamţ (1722-1794, both of them arrived from the Slav world in the Romanian extra-Carpathian territories. Saint Basil founded many hermitages and trained many disciples in the practice of the prayer of the mind or of the heart, becoming known as a great teacher of this prayer, in the modern times. Just as the Holy Fathers of Mount Sinai (Gregory, Philotheos, Hesychios, but also from other parts of the Byzantine world (Saint Symeon the New Theologian, Saint Gregory Palamas etc., once again, he draws the attention not just of the monks but also of the lay people on the prayer of the heart, so that in the 19th century it was not the teaching of Saint Paisius on the practice of the prayer of the heart that prevailed, but the teaching of Saint Basil, followed especially in the Romanian and in the Russian tradition. Regarding the monastic life, the activity of Starets Basil can be characterized by the ecumenicity of the Orthodox faith, due to the fact that, on the one hand, he brought together monks from the Romanian and the Slav area, and, on the other hand, he contributed to the enrichment of the Romanian monasticism through the
Topa, Maria Elena; Iavazzo, Pietro; Terracciano, Stefano; Adamo, Paola; Coly, Adrien; De Paola, Francesco; Giordano, Simonetta; Giugni, Maurizio; Traoré, Seydou Eric
Desertification is regarded as one of the major global environmental problems of the 21st century. The African sub-Sahara is often quoted as the most seriously affected region with a significant loss of biological and economic productivity of the land due to climate characteristics and fluctuations, unsustainable land uses, overgrazing and inappropriate agricultural practices. Due to its complexity, dynamism and extent, desertification is complicated to check and assess. The absence of an agreed methodology for the identification of affected areas is a critical point in desertification monitoring and assessment. An integrated approach which uses both qualitative and quantitative measures is crucial to reach the aim of sustainable resource use and has to be reflected in application of sets of indicators. The selection of appropriate indicators and their integration and interpretation should be conducted by the objectives to be achieved and the questions to be answered. This study, carried out within the FP7-ENV-2010 CLUVA project (Climate change and Urban Vulnerability in Africa), aimed to assess the sensitivity to desertification in peri-urban areas of both Ouagadougou (Burkina Faso) and Saint Louis (Senegal) cities. The approach was based on the implementation and adaptation to the local conditions of the modeling methodology developed within the MEDALUS project (Mediterranean Desertification And Land Use). The model is characterized by a multi-factor approach based on the assessment of both environmental quality indicators (vegetation, soil, climate) and anthropogenic factors (land management). All local data, arranged in a GIS environment, allowed the generation of maps identifying Environmentally Sensitive Areas (ESAs) and an Index of Environmentally Sensitive Areas (ESAI). Changes and integrations to the original methodology have been set taking into account the environmental and social features of the whole sub-Saharan west Africa in order to allow the use of
Kinsler, Veronica A.; Abu-Amero, Sayeda; Budd, Peter; Jackson, Ian J.; Ring, Susan M.; Northstone, Kate; Atherton, David J.; Bulstrode, Neil W.; Stanier, Philip; Hennekam, Raoul C.; Sebire, Neil J.; Moore, Gudrun E.; Healy, Eugene
Congenital melanocytic nevi (CMN) are pigmented birthmarks that affect up to 80% of the skin surface area. The increased frequency of CMN in families of severely affected individuals is suggestive of a predisposing germline genotype. We noted a high prevalence of red hair in affected families, and
Glud, M.; Klausen, M.; Gniadecki, R.
surgical specimens are formalin fixed and paraffin embedded (FFPE). To explore whether FFPE material would be suitable for miRNA profiling in melanocytic lesions, we compared miRNA expression patterns in FFPE versus fresh frozen samples, obtained from 15 human melanocytic nevi. Out of microarray data, we...
Iavazzo, P.; Terracciano, S.; Topa, M. E.; Adamo, P.; Coly, A.; De Paola, F.; Giordano, S.; Giugni, M.; Touré, H.
The United Nations Convention to Combat Desertification (UNCCD) defines desertification as "land degradation in arid, semi-arid and dry sub-humid areas resulting from various factors, including climatic variations and human activities". Desertification is regarded as one of the major global environmental problems of the 21st century and the African sub-Sahara is often quoted as the most seriously affected region with a significant loss of biological and economic productivity of the land. In this geographic area, desertification processes are usually generated by soil erosion due to climate characteristics and fluctuations, unsustainable land uses, overgrazing and inappropriate agricultural practices. Preventing desertification requires an improved understanding of its causes, impact, degree and association with climate, soil, water, land cover, socio-economic factors and their combined effects. The development of methodologies capable of managing large amounts of data in an integrated approach is needed because of the complexity and variety of forms of desertification processes. The study was carried out within the FP7-ENV-2010 CLUVA project (CLimate change and Urban Vulnerability in Africa), aimed to estimate the sensitivity to land degradation in the urban and peri-urban areas of both Ouagadougou (Burkina Faso) and Saint Louis (Senegal) cities. The approach was based on the implementation and adaptation of the modeling methodology developed within the MEDALUS project (MEditerranean Desertification and Land Use). The model is characterized by a multi-factor approach based on the assessment of both environmental quality indicators (climate, soil, vegetation) and anthropogenic factors (land management). The methodology is adaptable to the local conditions, considering that some key indicators can be operationally defined through the inclusion or exclusion of parameters and the scores assigned in order to match the specific relevance of the factors. All local data
Nicolle, Amandine; Dumas, Franck; Foveau, Aurélie; Foucher, Eric; Thiébaut, Eric
The king scallop ( Pecten maximus) is one of the most important benthic species of the English Channel as it constitutes the first fishery in terms of landings in this area. To support strategies of spatial fishery management, we develop a high-resolution biophysical model to study scallop dispersal in two bays along the French coasts of the English Channel (i.e. the bay of Saint-Brieuc and the bay of Seine) and to quantify the relative roles of local hydrodynamic processes, temperature-dependent planktonic larval duration (PLD) and active swimming behaviour (SB). The two bays are chosen for three reasons: (1) the distribution of the scallop stocks in these areas is well known from annual scallop stock surveys, (2) these two bays harbour important fisheries and (3) scallops in these two areas present some differences in terms of reproductive cycle and spawning duration. The English Channel currents and temperature are simulated for 10 years (2000-2010) with the MARS-3D code and then used by the Lagrangian module of MARS-3D to model the transport. Results were analysed in terms of larval distribution at settlement and connectivity rates. While larval transport in the two bays depended both on the tidal residual circulation and the wind-induced currents, the relative role of these two hydrodynamic processes varied among bays. In the bay of Saint-Brieuc, the main patterns of larval dispersal were due to tides, the wind being only a source of variability in the extent of larval patch and the local retention rate. Conversely, in the bay of Seine, wind-induced currents altered both the direction and the extent of larval transport. The main effect of a variable PLD in relation to the thermal history of each larva was to reduce the spread of dispersal and consequently increase the local retention by about 10 % on average. Although swimming behaviour could influence larval dispersal during the first days of the PLD when larvae are mainly located in surface waters, it has a
Ross, Julie A; Swensen, Andrine R; Murphy, Sharon E
Several adverse birth outcomes are associated with cigarette smoking. It is important to determine the prevalence of cigarette smoking among pregnant low-income women and to evaluate their smoking cessation patterns in order to target appropriate interventions. Ethnically diverse pregnant women aged 15-45 years were recruited from Minneapolis or Saint Paul Women, Infants, and Children (WIC) clinics before their third trimester. Serum cotinine levels were assayed for 98 women and compared with self-report. The women were unaware that their smoking status would be validated. Twenty-one (21%) women had a positive serum cotinine value (> or =3 ng/mL); 16 (76%) admitted smoking within the previous 24 h before interview and five denied smoking. Of the five, four had cotinine levels that could suggest passive smoke exposure. Thirty-seven women (38%) admitted cigarette smoking during the pregnancy but before knowing that they were pregnant; 18 (49%) of these denied current smoking at the interview and also presented with negative cotinine levels. These data suggest that some participants in WIC make a concerted effort to quit smoking when they find out they are pregnant, and are generally truthful when reporting their smoking habits during pregnancy.
PhD. Vîlciu Marian
Full Text Available The life and work of Saint Emperor Constantine the Great can be seen in two ways: as a Roman emperor, through the history, and the first Christian leader who reconciled the Church with State, by an ecclesiastical approach. Beginning with the reign of the Church acquires a privileged position in the state. Christianity became a lawful religion, equal in rights with other pagan religions and even more privileged and supported on the canonical, dogmatic and religious plan
Carrera, Cristina; Puig-Butillè, Joan A; Aguilera, Paula; Ogbah, Zighereda; Palou, Josep; Lecha, Mario; Malvehy, Josep; Puig, Susana
Sun damage is the most important environmental factor associated with malignant melanoma. To address the health threat, as well as the economic burden, primary prevention and early detection are crucial. To test the efficacy of a topical sunscreen in the prevention of UV-induced effects in nevi. Prospective study of nevi protected by sunscreen vs a physical barrier. Twenty-three nevi from 20 patients attending a referral hospital. Half of each nevus was protected by either a physical barrier or a sunscreen. Lesions were completely irradiated by a single dose of UV-B. In vivo examination before and 7 days after irradiation and histopathologic-immunopathologic evaluation after excision on the seventh day. The most frequent clinical changes after UV radiation were pigmentation, scaling, and erythema; the most frequent dermoscopic changes were increased globules/dots, blurred network, regression, and dotted vessels. Both physical barrier- and sunscreen-protected areas showed some degree of these changes. More than 30% (7) of nevi did not show any change on clinical examination, and 18% (4) had no dermoscopic change. Immunohistopathologic differences between the halves of each nevus were demonstrable even when in vivo examination detected nothing. Parakeratotic scale, increased number and activation of superficial melanocytes, and keratinocyte proliferation were the most remarkable features. The only difference between both barriers was more enhanced melanocytic activation and regression features in the sunscreen group. No phenotypic features were found to predict a specific UV-B response. Both physical barriers and sunscreens can partially prevent UV-B effects on nevi. Subclinical UV radiation effects, not always associated with visible changes, can develop even after protection. Sunscreens are not quite as effective as physical barriers in the prevention of inflammatory UV-B-induced effects.
Nevo da epidermólise bolhosa: aspectos clínicos, dermatoscópicos e histológicos em um caso de portador da forma distrófica recessiva Epidermolysis bullosa nevi: clinical, dermatoscopical and histological features in a case of recessive dystrofic form
Juliana Nakano de Melo
Full Text Available As lesões melanocíticas adquiridas podem apresentar aspecto clínico não-usual em pacientes portadores de epidermólise bolhosa hereditária. Essas lesões são conhecidas como "nevos EB" e, muitas vezes, constituem um desafio diagnóstico ao dermatologista por apresentarem características clínicas, dermatoscópicas e histopatológicas semelhantes às encontradas no melanoma. Não são exclusivas de nenhuma forma de epidermólise bolhosa e têm sua frequência aumentada na infância. Relata-se o caso de um doente do sexo masculino, de 6 meses de idade, portador da forma distrófica recessiva da doença, com lesão pigmentada de rápido crescimento na coxa esquerda. Optou-se por seguimento clínico da lesão, considerando que os aspectos clínicos, dermatoscópicos e histológicos eram compatíveis com a descrição de outros casos de nevo EB previamente descritosAcquired melanocytic lesions may present unusual clinical features in all forms of hereditary epidermolysis bullosa. These lesions are known as "EB nevi", and often pose a diagnostic challenge for dermatologists given their resemblance - clinically, dermoscopically and histologically - to melanoma. The lesions have been reported in all types of hereditary EB, most of them in childhood. We report the case of a 6-month-old boy suffering from recessive dystrophic epidermolysis bullosa (RDEB that presented as a large pigmented lesion on his left thigh. We decided to monitor the lesion closely since we considered that the clinical and pathological aspects of the lesion were compatible with the description of other previously reported cases of EB nevi
Arcan, Chrisa; Kubik, Martha Y; Fulkerson, Jayne A; Davey, Cynthia; Story, Mary
Availability of competitive foods in schools has been linked to unhealthful dietary behaviors of students. Little is known about the food environment of alternative high schools, schools that enroll students at risk of academic failure. We examined correlations between food opportunities during the school day and selected dietary behaviors of students attending alternative high schools. Baseline data were collected in fall 2006 as part of the Team COOL (Controlling Overweight and Obesity for Life) pilot study, a group randomized obesity prevention trial. Students (n = 145) attending 6 alternative high schools in Minneapolis/Saint Paul, Minnesota, completed a survey on food opportunities during the school day and selected dietary behaviors. We used mixed-model multivariate cross-sectional analysis and adjusted for demographic characteristics to examine associations of interest. Food opportunities during the school day were positively associated with overall consumption of sugar-sweetened beverages, high-fat foods, and fast-food restaurant use. Having many food opportunities during the school day at alternative high schools was linked to the consumption of foods and beverages high in sugar and fat and low in nutrients. School-based interventions should focus on changing the food environment in alternative high schools to decrease less healthful eating opportunities and to increase the availability of healthful foods and beverages.
Jankowska-Szmul, J; Dobrowolski, D; Krysik, K; Kwas, J; Nejman, M; Wylegala, E
The purpose of this work was to study the evolving trends in techniques and indications for corneal transplantation in Poland. This retrospective, descriptive analysis of corneal transplantations was performed at the Ophthalmology Department of Saint Barbara Hospital, Trauma Center, Sosnowiec, Poland, between 1988 and 2014. Structure of indications and surgery type rates over 26 years were tabulated by means of 5-year intervals. Between 1989 and 2014, 1762 corneal transplantations were performed, including 1375 (78%) cases of penetrating keratoplasty, 137 (8%) lamellar keratoplasty, 112 (6%) patch grafts, and 138 (8%) keratolimbal allografts. The major indications and their respective overall percentage were corneal leucoma (24%), pseudophakic/aphakic bullous keratopathy (22%), Fuchs dystrophy (13%), keratoconus (13%), re-graft (11%), keratitis (9%), and limbal stem cell deficiency (8%), with changes in relative frequency of the leading indications over the following time intervals. The number of corneal transplantations gradually increased during the years reviewed. The rates of lamellar, keratolimbal, and patch grafts have grown dynamically since 2010, reaching 20%, 17%, and 12%, respectively, of procedures performed during 2010 to 2014. Over the past quarter of a century, there has been evolution in corneal transplantation service, from the first penetrating keratoplasty to the wide spectrum of procedures, including femtosecond laser-assisted keratoplasty. Although, since 2010, the rates of lamellar and keratolimbal allografts have grown rapidly, penetrating keratoplasty has remained the leading technique. Copyright © 2016 Elsevier Inc. All rights reserved.
Tucci, G.; Bonora, V.; Conti, A.; Fiorini, L.
In recent years, the GeCo Laboratory has undertaken numerous projects to digitalize vast and complex buildings; the specific nature of the different projects has resulted in a case-by-case approach, each time working on past experiences and updating not only the hardware and software tools but also the management and processing methods. This paper presents the workflow followed for the survey of the Fortress of Saint John the Baptist in Florence, an on-going interdisciplinary project. Presently Florence's main trade fair congress centre, at the same time it hosts various buildings that bear witness to the fortress's life-history, combining constructions from the Medici and Lorraine eras with recently built exhibition facilities. Now new research has been required due to the realization of new pavilions and the regeneration of the whole complex. This has included a critical survey, material testing, diagnostic investigations and stratigraphic analyses to define the building's state of preservation. The working group comprises specialists from different institutions, amongst which the Italian Military Geographic Institute, the University of Florence, the National Research Council Institute for the Preservation and Enhancement of the Cultural Heritage, and the Florence City Council.
Berger, Aaron T; Qian, Xinyi Lisa; Pereira, Mark A
This study describes the association between frequency of bicycling for active transportation and modifiable cardiometabolic risk factors in the Minneapolis-Saint Paul (MSP) metropolitan area. We conducted an online survey from a convenience sample of likely bicycle commuters. Participants were e-mailed invitations including a link to the online survey. Participants (n = 1450, 15.6% response rate) were residents of the 7-county MSP metropolitan area aged 20 to 64 years. Participants reported frequency of commute and destination cycling from April to September and October to March, prevalent cardiometabolic risk factors, and demographic covariates. We performed logistic regressions for associations between average weekly transportation bicycling and self-reported prevalent obesity, high blood pressure, high cholesterol, low high-density lipoprotein cholesterol, and high triglycerides. We used Poisson regression for the count of cardiometabolic risk factors. All models were adjusted for age, sex, race, smoking, alcohol consumption, and other physical activity, with random intercepts by zip code. Self-reported bicycling frequency is associated with significantly lower odds of prevalent obesity, hypertension, and high triglycerides. Three bicycling trips per week is associated with 20% fewer (95% confidence interval: 12%-28%) cardiometabolic risk factors. Bicycling frequency is inversely associated with cardiometabolic risk factors. These results provide empirical support for the promotion of active transportation as public health policy.
Immigration, différence et intégration dans The Consul et The Saint of Bleecker Street de Gian Carlo Menotti Immigration, Difference and Integration in Gian Carlo Menotti’s The Consul and The Saint of Bleecker Street
Full Text Available Composer, librettist and stage director Gian Carlo Menotti has changed the American musical theatre by accepting to face burning questions related to his times, but which are at the same time universal. In The Consul (1950, the American context of the 1950s burst onto the operatic stage. The Mc Carron law and MacCarthysm are reflected in this opera which is, first of all, a metaphor of the negation of liberty. In The Saint ofBleecker Street (1954, the Little Italy microcosm suggests a new reflection about questions which are related to the concept of difference and integration, connected to considerations of a metaphysical and religious nature. As metaphors of American society, these two operas finally symbolise all kinds of human multicultural societies by revealing the polysemic character of Menotti’s works.
Mihail M. Gheaţău
Full Text Available Being remarkable through the monumentality and elegance of proportions, the architecture of the Church “Saint John the Baptist” from Bârnova derives from the so-called old Wallachian style, skillfully reshaping a structure which combines elements which are specific to Byzantine Balkanic ecclesiastical buildings. The unseen pictural work of Ștefan Constantinescu is characterized by the attempt to associate the results of experiencing freedom of interpretation and expression with the rules of the iconographic canon, inside the same ensemble. Its representations do not reproduce the traditional Byzantine manner, nor it is delivered as a form of quoting reality, but it is filtered and interpreted. From a theological point of view, the author respects the iconographic program, except for the topographic placement of some episodes, adapting the discourse according to the configuration and features of the liturgical space. We are in front of a case which places us in the position of managing the relationship between the value of artistic creation and the meticulosity of theological involvement. Neither Byzantine, nor realistic, the artistic solution of the mural painting from Bârnova is closer to the manner of iconic transfiguration than to the one of improvisation or artistic intermediation through which the daily tridimensional world is reflected.
Hublin, Jean-Jacques; Talamo, Sahra; Julien, Michèle; David, Francine; Connet, Nelly; Bodu, Pierre; Vandermeersch, Bernard; Richards, Michael P
The transition from the Middle Paleolithic (MP) to Upper Paleolithic (UP) is marked by the replacement of late Neandertals by modern humans in Europe between 50,000 and 40,000 y ago. Châtelperronian (CP) artifact assemblages found in central France and northern Spain date to this time period. So far, it is the only such assemblage type that has yielded Neandertal remains directly associated with UP style artifacts. CP assemblages also include body ornaments, otherwise virtually unknown in the Neandertal world. However, it has been argued that instead of the CP being manufactured by Neandertals, site formation processes and layer admixture resulted in the chance association of Neanderthal remains, CP assemblages, and body ornaments. Here, we report a series of accelerator mass spectrometry radiocarbon dates on ultrafiltered bone collagen extracted from 40 well-preserved bone fragments from the late Mousterian, CP, and Protoaurignacian layers at the Grotte du Renne site (at Arcy-sur-Cure, France). Our radiocarbon results are inconsistent with the admixture hypothesis. Further, we report a direct date on the Neandertal CP skeleton from Saint-Césaire (France). This date corroborates the assignment of CP assemblages to the latest Neandertals of western Europe. Importantly, our results establish that the production of body ornaments in the CP postdates the arrival of modern humans in neighboring regions of Europe. This new behavior could therefore have been the result of cultural diffusion from modern to Neandertal groups.
Genival Fernandes de Freitas
Full Text Available El objetivo de esta investigación de carácter histórico-social, consiste en contribuir a la reflexión crítica sobre el origen y desarrollo de la cultura de los cuidados en el contexto socio-político y religioso del renacimiento español (siglo XVI desde la perspectiva de la orden mendicante de San Juan de Dios. La filosofía humanística o antropológica de la enfermería, en la perspectiva mencionada, implicaba potenciar la atención holística en el proceso de satisfacción de necesidades de los pacientes considerando el binomio hospitalidad-humanización de la asistencia.This is a historical and social study has the objective to contribute to a critical reflection involving the origin and development of caring culture in the social-political and religious contextualization of Spanish Renaissance (century XVI, with the prospect of mendicant order of Saint John of God. Humanistic or anthropological Philosophy of Nursing, in this perspective, signified a holistic attention to needs of patients ruled in the binomial hospitality and humanization of care nursing.
Full Text Available The complex of the churches of Saint Constantine and Saint Mamas is located at Missochori, close to the capital of the island of Nissyros, Greece. The first church preserves wall-paintings dated to the end of the twelfth century, shared donation of two monasteries/churches. The paintings are partly repainted, probably in 1318/1319. Both the murals and the two inscriptions of the church provide new evidence concerning mediaeval Nissyros.
For 22 years Jacques Lisfranc was the famous surgeon at the Hospital La Pitté in Paris. He was born at Saint-Paul-en-Jarez in 1787, a village sited between Saint-Etienne and Lyon. After his Internship in Lyon he became Dupuytren's student in Paris. In his thesis, he described Dupuytren's operation of the removal of the lower jawbone. In 1815 he succeeded in new surgical operations on the shoulder and on the foot. In 1830 he was the first to perform the ablation of rectum's carcinoma and became the most famous gynaecological surgeon. He could not become a professor of the Faculty of Medicine in Paris because of his enmity with Dupuytren. Nevertheless he was only interested in surgery and the care for his patients. On his tomb, one can read his favourite maxim: "Surgery is bright when operating but it is still brighter when there is no blood and mutilation and yet leads to the patient's recovery".
Full Text Available The visitation records of Otto Friedrich Buchheim, the Bishop of Ljubljana from 1641–1664, offer an insight into the rules governing the disposition of saintly figures in altar retables. The central place was accorded to the titular saint, while companion saints are positioned in pairs (separately for each level of the retable in such a way that those of higher rank are placed on the more distinguished gospel side, whereas those of lower rank stand on the subordinate epistle side. The priority of one saint over another was not a matter of a random choice, but of a fixed hierarchical order which was created over the course of centuries in the Litany of All Saints and also in the hymns of the officium for All Saints Day; this hierarchy, as Buchheim remarks, is "in agreement with the general feeling of the Catholic Church". Ecclesiastical art in Slovenia shows that in the Gothic period the hierarchical principle governing the disposition of saintly figures was not yet firmly fixed, but it was fully established in the late Renaissance and Baroque periods, which coincides with the period of unification of the Litany of All Saints for the entire Catholic Church. Later it started to loosen again, yet it remained in force up to the 20th century.
Full Text Available Our paper is an interdisciplinary approach, of linguistic and theological analysis of a few lexemes that define saints who became popular in the Romanian culture and spirituality. Our ancient church, a fundamental part of our culture, has always been a coagulant factor for the unity of the Romanians worldwide. And this is also proven by the use of the religious vocabulary in all the anthropological, territorial, socio-professional and socio-cultural variants of the national Romanian language.
The purpose of the thesis was to investigate how to write a proper business plan and then implement gained knowledge in creating a business plan of a food truck in Saint Petersburg. A business plan serves as a guide for an entrepreneur in the process of company establishment and enables to gain funding from potential investors. The primary objective was to study essential components of a business plan. The theoretical framework comprises of core issues on company establishment and desc...
Sidorov, Roman; Soloviev, Anatoly; Krasnoperov, Roman; Kudin, Dmitry; Grudnev, Andrei; Kopytenko, Yury; Kotikov, Andrei; Sergushin, Pavel
Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS) - the Geophysical Center of RAS (GC RAS) and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb). On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG) for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.
Full Text Available Since June 2012 the Saint Petersburg magnetic observatory is being developed and maintained by two institutions of the Russian Academy of Sciences (RAS – the Geophysical Center of RAS (GC RAS and the Saint Petersburg branch of the Pushkov Institute of Terrestrial Magnetism, Ionosphere and Radio Wave Propagation of RAS (IZMIRAN SPb. On 29 April 2016 the application of the Saint Petersburg observatory (IAGA code SPG for introduction into the INTERMAGNET network was accepted after approval by the experts of the first definitive dataset over 2015, produced by the GC RAS, and on 9 June 2016 the SPG observatory was officially certified. One of the oldest series of magnetic observations, originating in 1834, was resumed in the 21st century, meeting the highest quality standards and all modern technical requirements. In this paper a brief historical and scientific background of the SPG observatory foundation and development is given, the stages of its renovation and upgrade in the 21st century are described, and information on its current state is provided. The first results of the observatory functioning are discussed and geomagnetic variations registered at the SPG observatory are assessed and compared with geomagnetic data from the INTERMAGNET observatories located in the same region.
The Workshop continues a series of workshops started by the Skobeltsyn Institute of Nuclear Physics of Lomonosov Moscow State University (SINP MSU) in 1985 and conceived with the purpose of presenting topics of current interest and providing a stimulating environment for scientific discussion on new developments in theoretical and experimental high energy physics and physical programs for future colliders. Traditionally the list of workshop attendees includes a great number of active young scientists and students from Russia and other countries. This year the Workshop is organized jointly by the SINP MSU and the SPbSU and it will take place in the holiday hotel "Baltiets" situated in a picturesque place of the Karelian Isthmus on the shore of the Gulf of Finland in the suburb of the second largest Russian city Saint Petersburg. Scientific program, the main topics to be covered are: * Higgs searches and other experimental results from the LHC and the Tevatron; impact of the Higgs-like boson observed * Physics prospects at Linear Colliders and super B-factories * Extensions of the Standard Model and their phenomenological consequences at the LHC and Linear Colliders * Higher order corrections and resummations for collider phenomenology * Automatic calculations and Monte Carlo simulations in high energy physics * LHC/LC and astroparticle/cosmology connections * Modern nuclear physics and relativistic nucleous-nucleous collisions * Detectors for future experiments in high energy physics The Workshop will include plenary and two parallel afternoon sessions. The plenary sessions will consist of invited lectures. The afternoon sessions will include original talks. Further details are given at http://qfthep.sinp.msu.ru
Hawryluk, Elena B; Liang, Marilyn G
Although pediatric melanoma is a rare disease, diagnosis and management of pigmented lesions in the pediatric population, particularly dysplastic nevi and Spitz nevi, can be challenging. In this article, we provide an overview of pigmented lesions in children, including melanoma and management of melanoma risk factors and melanocytic nevi in the pediatric population. Congenital melanocytic nevi, Spitz nevi, dysplastic and acquired nevi, and changes over time are reviewed. We discuss considerations for excision and management of pigmented lesions in children. Copyright © 2014 Elsevier Inc. All rights reserved.
Intramucosal melanotic nevus with multiple polypoid presentations in oral cavity is rare; though single nevus is not uncommon. Nevi are benign proliferations of nevus cells either in the epithelium or in the subepithelial stroma. They are best categorized as hamartomas rather than true neoplasm. We present a case of intramucosal melanotic nevi in a 26-year-old male patient, which clinically resembled hereditary fibrous gingival enlargement.
Full Text Available Intramucosal melanotic nevus with multiple polypoid presentations in oral cavity is rare; though single nevus is not uncommon. Nevi are benign proliferations of nevus cells either in the epithelium or in the subepithelial stroma. They are best categorized as hamartomas rather than true neoplasm. We present a case of intramucosal melanotic nevi in a 26-year-old male patient, which clinically resembled hereditary fibrous gingival enlargement.
Firsov Gennadiy Afanasyevich
Full Text Available Picea glehnii (F. Schmidt Mast. (the Glehns Spruce is a rare endangered species of the Russian Far East, a plant included into the Red Book of the Russian Federation. This species is in need of protection In situ and Ex situ. The Glehns Spruce is introduced in general cultivation in 1877. In Saint Petersburg it became known after the expedition of F. Schmidt and P.P Glehn to Sakhalin Island (in 1860-1861. In hand-written general catalogues of living collections of Peter the Great Botanical garden of the L.V. Komarov Botanical Institute of the Russian Academy of Sciences it has been known since 1892. In the North-West of Russia Picea glehnii is cultivated in two introduction centers botanical gardens of L.V. Komarov Botanical Institute and Saint Petersburg State Forest Technical University. In modern collections of Botanical gardens it has been cultivated since 1955. The plant began producing cones in 1996 in the age of 41. The fully ripen germinable seeds were obtained in September of 2014, and the seedlings were germinated in 2015, for the first time in more than 120 years of arboriculture. The assessment of seeds quality revealed the presence of filled high-quality seeds but their number was rather small (10-15% from the total amount. Picea glehnii is one of the most decorative and winter-hardy spruce species, promising for city planting in Saint Petersburg and for urban floristics in the North-West of Russia.
In the interests of enhanced safety, a new pathway for pedestrians and cyclists has been constructed around the outside of the Saint-Genis roundabout. However, the markings of the previous cycle path, which is now closed to traffic, are still visible and can cause confusion. We therefore call on everyone to exercise extreme caution and to use the new pathway. New two-way markings have been laid out, inviting pedestrians and cyclists coming from the direction of Saint-Genis-Pouilly to go towards the Swiss border or CERN Entrance E using the left-hand side of the roundabout (i.e. the Prévessin side). So, from now on, cyclists must no longer go around the roundabout on the right-hand side and pedestrians will no longer have to cross the D884 dual carriageway. Similarly, people staying at the Saint-Genis hostel are invited to follow these new markings to get to CERN or to return to the hostel, which means they will avoid having to cross the D35 highway at a spot where traffic is...
Full Text Available The relics of Turku Cathedral are remains belonging to the bodies of holy persons, different from ours, even today, although the cathedral is the see for the archbishop of the Evangelical Lutheran Church of Finland, and relics are not on public display. Among the relics of the cathedral, there is a fragment of a radius, which according to its authentica, belongs to St Henry. Relics and reliquaries were in the core of medieval piety, and the cult of saints had infused throughout the society. Due to their central position in culture, relics offer glimpses at a range of material, social and cultural phenomena related to medieval embodiment.The Department of Archaeology at the University of Turku began to study the finger relic of St Eric and other items in the assemblage of Turku Cathedral in 2007. Relics and reliquaries are being opened and documented and organic as well as inorganic samples are being taken for a range of scientific analyses. So far the project has concentrated on building a chronological chart of individual artefacts. The majority of the relics date to the fourteenth century, although much more recent datings have also been obtained. The challenge of the project is not to stop when a better understanding of materials, their origins and age has been accomplished, but to use the results as a steppingstone into a study of the practices of medieval relic veneration. Medieval bodies and those material processes which authenticate relics, or distinguish saints’ bodies from other human remains, are thus at the heart of this article discussing embodiment.
Walfrido Kühl Svoboda
Full Text Available Introduction Saint Louis encephalitis virus (SLEV primarily occurs in the Americas and produces disease predominantly in humans. This study investigated the serological presence of SLEV in nonhuman primates and horses from southern Brazil. Methods From June 2004 to December 2005, sera from 133 monkeys (Alouatta caraya, n=43; Sapajus nigritus, n=64; Sapajus cay, n=26 trap-captured at the Paraná River basin region and 23 blood samples from farm horses were obtained and used for the serological detection of a panel of 19 arboviruses. All samples were analyzed in a hemagglutination inhibition (HI assay; positive monkey samples were confirmed in a mouse neutralization test (MNT. Additionally, all blood samples were inoculated into C6/36 cell culture for viral isolation. Results Positive seroreactivity was only observed for SLEV. A prevalence of SLEV antibodies in sera was detected in Alouatta caraya (11.6%; 5/43, Sapajus nigritus (12.5%; 8/64, and S. cay (30.8%; 8/26 monkeys with the HI assay. Of the monkeys, 2.3% (1/42 of A. caraya, 6.3% 94/64 of S. nigritus, and 15.4% (4/26 of S. cay were positive for SLEV in the MNT. Additionally, SLEV antibodies were detected by HI in 39.1% (9/23 of the horses evaluated in this study. Arboviruses were not isolated from any blood sample. Conclusions These results confirmed the presence of SLEV in nonhuman primates and horses from southern Brazil. These findings most likely represent the first detection of this virus in nonhuman primates beyond the Amazon region. The detection of SLEV in animals within a geographical region distant from the Amazon basin suggests that there may be widespread and undiagnosed dissemination of this disease in Brazil.
Sammartano, G.; Spanò, A.
Delineating accurate surface water quality levels (SWQLs) always presents a great challenge to researchers. Existing methods of assessing surface water quality only provide individual concentrations of monitoring stations without providing the overall SWQLs. Therefore, the results of existing methods are usually difficult to be understood by decision-makers. Conversely, the water quality index (WQI) can simplify surface water quality assessment process to be accessible to decision-makers. However, in most cases, the WQI reflects inaccurate SWQLs due to the lack of representative water samples. It is very challenging to provide representative water samples because this process is costly and time consuming. To solve this problem, we introduce a cost-effective method which combines the Landsat-8 imagery and artificial intelligence to develop models to derive representative water samples by correlating concentrations of ground truth water samples to satellite spectral information. Our method was validated and the correlation between concentrations of ground truth water samples and predicted concentrations from the developed models reached a high level of coefficient of determination (R2) > 0.80, which is trustworthy. Afterwards, the predicted concentrations over each pixel of the study area were used as an input to the WQI developed by the Canadian Council of Ministers of the Environment to extract accurate SWQLs, for drinking purposes, in the Saint John River. The results indicated that SWQL was observed as 67 (Fair) and 59 (Marginal) for the lower and middle basins of the river, respectively. These findings demonstrate the potential of using our approach in surface water quality management.
One concern in human genetics research is maintaining the privacy of study participants. The growth in genealogical registries may contribute to loss of privacy, given that genotypic information is accessible online to facilitate discovery of genetic relationships. Through iterative use of two such web archives, FamilySearch and Sorenson Molecular Genealogy Foundation, I was able to discern the likely haplotypes for the Y chromosomes of two men, Joseph Smith and Brigham Young, who were instrumental in the founding of the Latter-Day Saints Church. I then determined whether any of the Utahns who contributed to the HapMap project (the "CEU" set) is related to either man, on the basis of haplotype analysis of the Y chromosome. Although none of the CEU contributors appear to be a male-line relative, I discovered that predictions could be made for the surnames of the CEU participants by a similar process. For 20 of the 30 unrelated CEU samples, at least one exact match was revealed, and for 17 of these, a potential ancestor from Utah or a neighboring state could be identified. For the remaining ten samples, a match was nearly perfect, typically deviating by only one marker repeat unit. The same query performed in two other large databases revealed fewer individual matches and helped to clarify which surname predictions are more likely to be correct. Because large data sets of genotypes from both consenting research subjects and individuals pursuing genetic genealogy will be accessible online, this type of triangulation between databases may compromise the privacy of research subjects.
Quddus, M Ruhul; Rashid, Lanita B; Sung, C James; Robinson-Bostom, Leslie; Lawrence, W Dwayne
A 30-year-old female presented with a 0.3 cm slightly raised tan-brown papule with somewhat irregular borders on her right labia minora. The papule was detected by her gynecologist during an annual gynecologic visit. Excision of the lesion revealed an atypical melanocytic nevus of genital type (AMNGT). This nevus is often confused with other pigmented lesions especially dysplastic nevus or even malignant melanoma. This distinctive melanocytic nevus often causes significant concern to pathologists and dermatologists. The diagnostic criteria and differentiating features from dysplastic nevi and malignant melanoma are discussed.
President Toomas Hendrik Ilves esines 9. mail 2009 Šveitsis, Saint Galleni 39. majandus- ja poliitikasümpoosionil kõnega teemal "20 aastat pärast Berliini müüri langemist - Euroopa uued väljakutsed". Vabariigi President töövisiidil Šveitsis 08.-09.05.2009
van Dongen, Els
In this article the author writes about mundane pragmatics, or everyday deeds, in times of suffering and uncertainty. Such pragmatics differ from cultural practices such as biomedical therapies or individual health-seeking behaviour patterns. Medical anthropologists and others working in the field of health and illness often overlook such pragmatics. However, these actions are of great social value and express the connectedness and bonds between people. They also express our deep beliefs, hopes, powerlessness and vulnerability.
Adam VAKHTANG AKHALADZE
Full Text Available In this study we analyze the biographical and hagiographical life and multifaceted activities of St. Anthim the Iberian in cross-cultural communicative dimension. Modern Post-Global world and its Weltanschauung need not onlytrans(cross-cultural, but also trans-historical contexts. We have designated the existence of trans-cultural polylogue (dialogue of many between all historical eras and ethnicities with their cultural codes and symbols. Our research enabled us to identify the following parameters of trans-cultural communicative competence: (i adequately assess the communicative situation; (ii possession of a certain body of knowledge about the native and other cultures; (iii to put into practice intercultural communicative intentions; (iv presence of not only the ability to understand other cultures, as well as members of their own culture, but also the ability to build new patterns of behavior, based on the values and norms of different cultures; (v strive to mix our own and others' cultural identity and as a result of the exchange of positive examples of actions and patterns of decision-making to go to a qualitatively new synthesis of action; (vi check the communication results with the help of feedback. We also identified the following aspects and facts of life and activity of Anthim the Iberian in the context of cross-cultural communicative competence: (a getting a wonderful upbringing (social intercultural communicative abilities and skills, and education (the possession of a certain body of knowledge about both native and other cultures, understanding and respect for diverse cultural values; (b the forced emigration of the native culture medium (communicative and behavioral adaptation to the behavior of other cultures; (c the experience of cruelty trafficking – the kidnapping and slavery sale (the religious-spiritual, social and cross-cultural communicative negative experience and its interpretation in a truly constructive manner that
Bakhtin's [(1981). "The dialogic imagination: Four essays." (C. Emerson & M. Holquist, Trans. M. Holquist, Ed.). Austin: University of Texas Press] concept of the chronotope is used as a lens to view time and place in stories of psycho-spiritual transformation in research and therapy. Distinctions between spirituality,…
Full Text Available In this paper, we look at the interregional cooperation in adjacent areas. Specifically, we focus our attention on the cluster of regions formed by the city of St. Petersburg, the Leningrad region and the Republic of Karelia. All three areas face a number of challenges when it comes to international trade: challenges that are shared and that require strategic coordinated solutions from regional decisionmakers. One of such solutions, for example, could require pooling of competitive advantages of these areas. The analysis of strategic documents of regional development, however, shows that the issue of interregional cooperation has not been duly addressed at any level, theoretical or practical. It is important to strengthen international trade capacity and to increase cooperation in other areas of cross-border relations, since these processes are crucial for Russia’s integration into the global markets.
Benarous, X; Guedj, M J; Braitman, A; Gallois, E; Lana, P
The link between depression and aggressive behavior in adults has been found in many studies. In adolescents, this relationship is still controversial. Several studies point out that irritability is a key symptom in adolescent depressed. Few studies have analyzed precisely the kind of aggressive behavior. This study sets out to assess the relationship between aggressive behavior and depressive affects in adolescents. We also pay attention in this population to hopelessness feelings, anxiety, global functioning and the type of aggressive behavior. This is a descriptive and observational cross-sectional study. Data was collected from 49 successive adolescents admitted for a 24-hour evaluation in the emergency department of the Sainte-Anne psychiatric hospital. The inclusion period was from February to April 2012, with age limits between 15 and 18. For each patient, the clinician completed with the parents or other caregivers the Modified Overt Aggressive Scale (MOAS) searching for existence of aggressive behavior in the week prior to the consultation. The population was divided into two groups: P- group when the MOAS score was Aggression Questionnaire (QA), the Beck Hopelessness scale and the Adolescent Depression Rating Scale for patients (ADRSp). Forty-nine adolescents with a median age of 16 years and 4 months participated. The first reason for consultation was depressive symptoms, followed by disruptive behavior. The analysis was conducted on 39 questionnaires. The demographic profile of the two groups was similar. We did not find any significant difference between the groups P+ and P- on ADRSc scores and secondary criteria. However, we found higher scores in the QA in the more depressed patient, especially a higher hostility score in this sample. In the subgroup analysis: as expected self-aggressive behavior was associated with a higher depression score, more hospitalization and a poor global functioning score. Surprisingly, the patients who showed physical
MicroSAINT Models of the Close-In Weapon System (CIWS): Sensitivity Studies and Conformal Mapping of Performance Data (CISWENS). Subtitle: Exploring the Utility MicroSAINT Models: CIWS Loading Operation Models Under Normal and MOPP IV Conditions
operation is, in some sense, understaffed. Thus, if everything worked like clockwork , the loading operation was completed quickly. Otherwise a delay in...and so forth so that one risks mixing ’apples and oranges ’. Second, there ik no control over the range of variables represented in such a database
Full Text Available The rules of monasticism were collected and published in a single work entitled Asketikon by Saint Basil the Great. It is arranged in the form of questions and answers to create one coherent work. It has two different publications.The first publication named The Small Asketikon dates to 370-370. It is the fruit of the Saint’s work among Pontic communities and consists of 203 questions and answers. The orignial Greek manuscript has not survived and it is available only in two translations: the Latin Rufin and fragments in Syrian language. The second publication named The Great Asketikon appeard in about 377 and presents the most mature step of cenobitic monasticismin Basil’s elaboration. The Great Asketikon was created by adding new questions to The Small Asketikon and consists of two parts called the The Longer Rules and The Shorter Rules. The Longer Rules are primarily a set of questions and answers. It includes a wide range of rules and norms of the overall life in community. It refers to the fundamental rules of spirituality, such as love, sacrifice, obedience and rudimental problems connected withcommunity organization, cenobitic monasticism and the role of the superior, work and prayer. The second part of The Great Asketikon consists of shorter rules. Two publications are known: the first one originated in Pont andincludes 286 questions and answers and second arose in Cezarei and includes 318 questions and answers. In this work, the Hierarch explains in detail issues regarding community life and solves difficult problems connected with conscience. He writes about behavior towards brothers and explains the significance of weaknesses and virtues.
Full Text Available La brique est le fruit du travail de l'homme, ce qui lui confère un statut singulier, bien différent de celui de la pierre. Elle peut être très résistante et d'une extrême sophistication. Mais, le plus souvent, faute d'une cuisson parfaitement contrôlée, elle est assez irrégulière voire d'une grande rusticité. Ces imperfections ont souvent suscité de la part des architectes et des maçons la volonté d'améliorer l’aspect et la pérennité des maçonneries de briques. C’est ainsi que dans tous les pays d’argile, la brique fait l’objet d’une multitude de traitements de surface et de recherche de décoration : surfaçages, peintures, enduits protecteurs animés par des briques feintes, etc. Parallèlement, les belles couleurs de la brique et sa souplesse d’utilisation ont généré une grande variété de mises en œuvre d’autant plus riches que les maîtres maçons ont utilisé de belle manière la polychromie brique et pierre, les jeux subtils des joints dont on sait l’importance qu’ils jouent dans les maçonneries de petit appareil, ou encore les assemblages les plus recherchés. Quelles soient apparentes, peintes ou totalement feintes, les briques ont partout suscité ce que l’on peut appeler une « culture de l’apparence ».Brick is man-made, which gives it a special status quite different to that of stone. It can be highly resistant and also extremely sophisticated. But usually, because of poorly controlled firing, it is quite irregular or even very rustic. These imperfections have often prompted architects and masons to seek to improve the appearance and durability of brick masonry. For this reason, in clay-producing countries, brick has undergone numerous surface and decorative treatments: surfacing, painting, protective coatings with imitation brickwork, and so on. The fine colours of brick and its flexibility as a material have lent it to a wide variety of uses. Skilled masons have produced fine brick
Full Text Available Patriarch Ephrem, monk and hermit, writer and saint, Bulgarian-born but twice the leader of the Serbian Church (1375-78 and 1389-92, is an outstanding figure of the late medieval Balkans. His "life and works" are discussed here in the light of hagiological texts and the information provided by various types of sources with the view to drawing some historically relevant conclusions. The main source of information about Ephrem's life and activity are the eulogies, Life and service composed by bishop Mark, his disciple and loyal follower for twenty-three years. Making use of hagiographical topica combined with plentiful data of undoubted documentary value, he relates the story of Ephrem's life through all of its major stages: from his birth and youth to his withdrawal from the world and taking of a monk's habit. Of formative influence were his years on the Holy Mount Athos, where he experienced different styles of monastic life, coenobitic, as well as solitary, which he practiced in the well-known hermitages in the heights of Athos. The further course of Ephrem's life was decided by the turbulent developments in the Balkans brought about by the Ottoman conquests. In that sense, his biography, full of forced and voluntary resettlements, is a true expression of the spirit of the times. Forced to flee Mount Athos, Ephrem made a short stay in Bulgaria and then, about 1347, came to Serbia, where he spent the rest of his life. An eminent representative of the monastic elite and under the aegis of the Serbian patriarch, he spent ten years in a hesychastria of the Monastery of Decani. For reasons of security, he then moved to a cave hermitage founded specially for him in the vicinity of the Patriarchate of Pec. It was in that cell, where he lived for twenty years powerfully influencing the monastic environment, that his literary work profoundly marked by hesychast thought and eschatology, was created. Ephrem twice accepted the office of patriarch in the
Helmbold, Peter; Richter, Antje M; Walesch, Sara; Skorokhod, Alexander; Marsch, Wolfgang Ch; Enk, Alexander; Dammann, Reinhard H
The Ras association domain family (RASSF) consists of several tumor suppressor genes, which are frequently silenced in human cancers. We analyzed the epigenetic inactivation of RASSF2 and RASSF10 in malignant melanoma (MM) of the skin, including 5 MM cell lines, 28 primary MM, 33 metastases of MM, 47 nevus cell nevi (NCN), and 22 control tissues. The RASSF2 promoter was epigenetically downregulated in two MM cell lines only, but not in any of the investigated tumor samples. In contrast, hypermethylation of the RASSF10 promoter was found in all investigated cell lines, 19/28 (68%) of the primary MM and 30/33 (91%) of the MM metastases, 2/18 (11%) of the dysplastic NCN, and 0/29 (0%) of the non-dysplastic NCN (difference between MM and all nevi, Ptreatment with a DNA methylation inhibitor reactivated RASSF10 transcription. Furthermore, immunohistological RASSF10 expression corresponds negatively to its promoter methylation state. In summary, RASSF10 proved to be a characteristically epigenetically silenced tumor suppressor in melanomagenesis, and analysis of RASSF10 methylation status represents a new candidate tool to assist in discrimination between MM and NCN.
Walesch, Sara K.; Richter, Antje M. [Institute for Genetics, Justus-Liebig-University Giessen, D-35392 Giessen (Germany); Helmbold, Peter [Department of Dermatology, University of Heidelberg, D-69120 Heidelberg (Germany); Dammann, Reinhard H., E-mail: firstname.lastname@example.org [Institute for Genetics, Justus-Liebig-University Giessen, D-35392 Giessen (Germany)
Epigenetic inactivation of tumor-related genes is an important characteristic in the pathology of human cancers, including melanomagenesis. We analyzed the epigenetic inactivation of Claudin 11 (CLDN11) in malignant melanoma (MM) of the skin, including six melanoma cell lines, 39 primary melanoma, 41 metastases of MM and 52 nevus cell nevi (NCN). CLDN11 promoter hypermethylation was found in 19 out of 39 (49%) of the primary MM and in 21 out of 41 (51%) of the MM metastases, but only in eight out of 52 (15%) of NCN (p = 0.001 and p = 0.0003, respectively). Moreover, a significant increase in the methylation level of CLDN11 from primary melanomas to MM metastases was revealed (p = 0.003). Methylation of CLDN11 was significantly more frequent in skin metastases (79%) compared to brain metastases (31%; p = 0.007). CLDN11 methylation was also found in five out of six MM cell lines (83%) and its promoter hypermethylation correlated with a reduced expression. Treatment of MM cell lines with a DNA methylation inhibitor reactivated CLDN11 transcription by its promoter demethylation. In summary, CLDN11 proved to be an epigenetically inactivated tumor related gene in melanomagenesis, and analysis of CLDN11 methylation level represents a potential tool for assisting in the discrimination between malignant melanoma and nevus cell nevi.
Full Text Available Construite par Claude Parent et Paul Virilio en 1964-1965, l’église Sainte-Bernadette du Banlay témoigne de leurs travaux sur la fonction oblique. L’édifice fut édifié à l’issue d’un concours d’architecture lancé en 1963 par Mgr Vial et l’Abbé Bourgoin, curé de la paroisse. L’église est inspirée de l’architecture des bunkers. Deux coques de béton s’imbriquent l’une dans l’autre en se décalant par rapport à l’axe longitudinal. L’apparence générale est un édifice monolithique, qui évoque un rocher. Á l’intérieur, deux grands plans obliques paraissent exhumés pour constituer la nef et le chœur. En relation étroite avec la grotte des apparitions de Lourdes, l’église est construite comme une crypte suspendue dont la coupe adopte la forme d’un cœur. Par le choix de matériaux bruts et d’un éclairage zénithal, les architectes confèrent à l’ensemble une étonnante intimité. C’est par l’opposition entre le volume extérieur austère et fermé et l’espace intérieur accueillant et protecteur que les concepteurs expriment la nouvelle fonction d’une église conçue dans une période d’incertitude et de tensions.The Sainte-Bernadette du Banlay church at Nevers was built from 1964 to 1965 to the designs of the architects Claude Parent and Paul Virilio, working on their theme of the oblique function. It was the fruit of an architectural competition organised in 1963 by Monseigneur Vial and the Abbé Bourgoin, the parish priest. The church’s architecture is inspired by that of defensive bunkers. Two reinforced concrete shells are joined the one into the other but out of true on a longitudinal axis. The overall appearance of the church is that of a monolithic block, something like a rock. Inside, two large oblique planes seem to emerge to create the nave and the chancel. Closely related to the Lourdes grotto of the Virgin’s appearances, the church is designed as a suspended crypt
Wheeler, Wendy Neifeld
Day in and day out the author invests her energy in keeping students safe by reducing alcohol consumption on campus, developing innovative alcohol and drug educational programming, collecting and analyzing data to better understand the drinking culture of the campus, and scouring the literature for best practices and evidence-based success. Day in…
Niki de Saint Phalle's lifelong dialogue between art and diseases: psychological trauma of sexual abuse, transient selective IgA deficiency, occupational exposure to toxic plastic material, chronic lung disease, rheumatoid arthritis.
The French artist Niki de Saint Phalle (1930-2002) is one of the most famous female painter and sculptor of the 20th century. Her eventful live was full of emotional and physical burdens such as abuse by the father as a adolescent, early separation from family, nervous collapse, turbulent relationship with the artist Jean Tinguely, and last not least serious diseases. The psychological trauma of sexual abuse together with a "nervous breakdown" years later was the start of a life as an artist and is also a key to her art of the early years. She was affected from rheumatoid arthritis (RA) and was treated over 20 years with prednisolone and antimalarials leading to a good functional outcome and limited erosions of the wrist joint. Additionally, she had lifelong pulmonary disorders finally leading to death, which she attributed to polyester, the material used for her sculptures. An analysis of medical documents collected by her and provided by treating physicians gives another surprising explanation: selective IgA deficiency with multiple recurrent respiratory infections, asthma, milk intolerance, autoimmune thyroiditis, and RA compatible with hypogammaglobulinemia. Very unique in case of Niki de Saint Phalle is that IgA deficiency was transient. Nevertheless, it may be possible that the occupational exposure with art materials (polystyrene, polyester) has contributed in part or temporarily to her health problems. Altogether, her enormous artistic productivity represents an outstanding example of creative coping with RA and other lifelong health problems. Copyright © 2013. Published by Elsevier SAS.
Kathleen A. Culhane-Pera
Full Text Available As a family physician and medical anthropologist, I have interacted with pregnant women and their families in Minnesota since 1983 and in one Hmong village in Northern Thailand since 1988. In the previous article I describe our recent research about Hmong families’ pregnancy and birth practices in Thailand. In this article, I reflect upon the differences in Minnesota and Thailand, consider what socio-cultural factors may be influencing people’s experiences, and speculate that Minnesota Hmong experiences could be helpful to Thai Hmong.
Ruzics, Ervin P; Abe, Marlene; Escobedo, Wendy; Gull, Paula; Weil, Marya
We report 99 consecutive renal transplants between 7/1/04 and 6/30/07 with 100% 3-year graft survival, statistically higher than expected per the SRTR (p one with Thymoglobulin (p = 0.01). Immunosuppression, infection prophylaxis and surveillance, and all medical and social issues potentially impacting graft or patient survival were managed by the transplant center for the first year minimum, and as long as clinically indicated post-transplant. Patients were educated to have all subsequent medical and social issues triaged by the transplant center for the life of the transplant.
This study examined reasons for the recent wave of immigration to the Minneapolis/St. Paul, Minnesota, area, interviewing Hmong, Somalis, Russians, and Hispanics/Latinos who were born outside of the United States. Interviews examined reasons for leaving the native land, what immigrants found when they arrived, and how they coped and adapted. Most…
Joanna Jadwiga Zamorska
Full Text Available Food and alcohol are the key elements of celebrating a Mexican fiesta. I show that drinking at patronal feasts can be the way of constructing a respectful position, as presented in the ethnographic material collected in the three suburban communities of the Central Valleys of Oaxaca (in the years 2012–13. I discuss the relation between drinking alcohol at fiestas, participation and collective identity. I analyse the issue of prestige in the context drinking at fiestas and its relation to gender. I also discuss the role of alcohol in ritual exchanging of gifts at the patronal feasts which were under study and its relation with prestige. Other questions being analysed include the problem of refusing drink and the Catholic and non-Catholic critiques of patronal feasts as based on perceptions of excessive drinking.
Pambour, Kwabena Addo; Cakir Erdener, Burcin; Bolado-Lavin, Ricardo; Dijkema, Gerhard P.J.
The integration of renewable energy sources into existing electric power systems is connected with an increased interdependence between natural gas and electricity transmission networks. To analyse this interdependence and its impact on security of supply, we developed a novel quasi-dynamic
Full Text Available Saint Parascheva or Saint Friday (Saint Petca entered the realm of imagination in old Romanian culture through canonical literature. The passage of this character from canonical to apocryphal literature is part of a transfer facilitated by the absence of distinctions between genres in ancient times. The common system of tracing the origins of the most widespread literary types – homilies, hagiographies, folk novels, chronographies, etc. – as well as the specific conditions of reception in ancient times has allowed the moving of the characters from one genre to another, without forcing the limits of plausibility required by certain reading habits and precarious scientific information. Such mutations are not visible predominantly in the case of historical characters that have become characters of an entertaining literature frequently using instruments of the fantastic as being significant when the characters derived from the historical space (see Alexander the Great enter the fantastic realm, which has a long tradition in the literature of entertainment. The work suggests a reception route, as well as a writing route that the canonical character Saint Parascheva traveled passing from religious to apocryphal and folklore literature. Referring to the variant of the legend of Saint Friday from Codex Sturdzanus we would thus like to point out the patterns that facilitated the assimilation of this character in Romanian folklore and thence allowed its access to religious collective memory. Sticking to a route imposed by preestablished labels and stereotype formulae, the legend confirms the mechanisms of production and typology-rendering specific to folklore literature.
Full Text Available This research is an attempt to make the analysis of possible solutions to the problem of the land where the Okhta Center was to be constructed. The authors studied the case from the historical, practical and cultural sides. In order to find out the current public opinion on this matter two surveys were held both among St Petersburg residents and foreign guests of the city. The main aims of this article were to find the solutions, that would lead to improvement in the cultural and social level of St Petersburg citizens’ life. The possible outcomes of this research are increasing incomes of the city budget, raising the status of the city and the development of Krasnogvardeisky region of St. Petersburg.
N. V. Gonchar
Full Text Available The aim of the study was to study the dynamics of the incidence of salmonellosis children in St. Petersburg and phenotypic resistance of clinical isolates of S. Enteritidis and S. Typhimurium to antibiotics in recent years. Materials and methods. The incidence of salmonellosis children studied according to the report for the first nine months of Rospotrebnadzor in 2013–2014. Incidence of salmonellosis in the structure of bacterial intestinal infections caused by pathogens in children hospitalized in the Department of intestinal infections in 2013–2014, studied according to annual reports. Antibiotic sensitivity was studied 86 Salmonella isolates (S. Enteritidis strain 64 and strain 22 S. Typhimurium, isolated from patients in children 2010–2014. Used the method of serial microdilution broth. Salmonella isolates were divided into sensitive, resistant, intermediate sensitivity to antibiotics. The Results. Analysis of the incidence of salmonellosis children of St. Petersburg has revealed its decline in 2014 (109.2 compared to 2013 (123,9 but relatively long-term average level was an increase in incidence (107,6. In the structure of salmonellosis in children prevailed salmonellosis Group D. In hospitalized children in the structure of bacterial intestinal infections detected Excess of share of salmonellosis in 2014 (36,9±3,4% compared to 2013 (24,5±2,4%; p <0,01. A reduction in the frequency sensitivity of S. Enteritidis to ampicillin, cefepime, ceftazidime and chloramphenicol. Compared to S. Enteritidis S. Typhimurium isolates were more resistant to ceftazidime and ampicillin, but more sensitive to ciprofloxacin. Conclusion. Morbidity of salmonellosis in recent years characterized by a relatively long-term average increase of the level. In the structure of salmonellosis in children prevailed salmonellosis Group D. There was a reduction of sensitivity S. Enteritidis isolates to cephalosporins new generations, and S. Typhimurium isolates
Maja Parmač Kovačić
Full Text Available The aim of the study was to test Paulhus' (2002 assumption that it is possible to separate egoistic from moralistic socially desirable responding (SDR on an unconscious and conscious level. The study was conducted on a convenient sample of students (N=206, which filled-in a five-factor personality questionnaire (IPIP100 in three dependent situations: honest responding, induced egoistic bias and induced moralistic bias. Along with the participants, four of their acquaintances were also included in the study; their assignment was to rate the participants on the IPIP100 questionnaire items. In order to test whether it is possible to separate egoistic from moralistic SDR, we used discrepancy measures on five personality dimensions – residuals from the regression of the self-reports in the honest situation on the corresponding peer-ratings indicating unconscious SDR, and residuals from the regression of the self-reports in the induced bias situations on the corresponding self-ratings in the honest situation indicating conscious SDR. Obtained results showed that discrepancy measures did not result with the expected factors of egoistic and moralistic SDR. Whereas discrepancy measures that indicated unconscious SDR formed one factor, discrepancy measures that indicated conscious SDR formed two factors, but they did not correspond to the egoistic and moralistic bias. The results suggest that it is not possible to separate egoistic from moralistic SDR neither on the unconscious nor on the conscious level.
Full Text Available The role of English as an international language has made its teaching a growing field. Despite its unofficial status in countries like Senegal, English is used in all fields of activity. Specialization of content in English-teaching curricula is currently increasing, and authors agree that English is not to be studied simply for its own sake, but rather for its communicative uses. EFL teachers are expected to help students develop fluency in English and become familiar with the English specific to their content area, which is the main reason why the field of ESP (English for Specific Purposes developed in contrast with General English. Specialists have been exploring learners’ needs in ESP in many parts of the world, because, as Munby (1978, Hutchinson & Waters (1987, and Dudley-Evans & St. John (1998 point out, needs analysis is of primary importance in teaching ESP. However, in Senegal, there has been less research focusing on the students’ learning needs. Senegalese students in content areas notice when they become job seekers that their level of English is lower than the labor market’s requirements. Using a qualitative approach, this study addresses that issue. It explores the role English plays in professional domains and assesses the learning needs for the professionals working in the fields of Business and Tourism. The purpose of this study is to help reduce the gap that currently exists between the English instructional programs and the job market’s requirements in order to produce graduates that meet the labor market’s expectations.
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Dance has often been a significant part of a cultural heritage. Most of the religious organizations which were formed just after the United States achieved its independence, however, rejected many European religious customs, including dance. Despite this, the Mormon church not only allowed dance, but advocated and sponsored it. Dance was an…
Full Text Available This article commemorating the 500th anniversary of the birth of Teresa of Avila has two purposes: one, the presentation and analysis of a newly discovered poem composed in honor or Teresa of Avila in the French Carmelite convent of Saint-Denis (Paris and two, a brief overview of recent scholarly work on French Carmelite poetry. It is proposed in the article that the poems of Teresa of Avila, not always considered important in their own right, should be re-considered and re-contextualized as foundational texts in a long tradition of Carmelite poetry that is both international and multilingual. Aquest article commemoratiu del 500 aniversari del naixement de Teresa d’Àvila té dos propòsits: el primer, la presentació i l’anàlisi d’un poema acabat de descobrir i fet en honor de Teresa d’Àvila al convent carmelità francés de Saint-Denis (París i, en segon lloc, una breu descripció del treball acadèmic recent sobre la poesia carmelitana francesa. Es proposa a l’article que els poemes de Teresa d’Àvila, no sempre considerats importants per dret propi, s’han de tornar a considerar i recontextualitzar com textos fundacionals d’una llarga tradició de la poesia dels carmelitans, que és, alhora, internacional i multilingüe.
Quercus rubra), hemlock and willow are also present; (4) Mixed deciduous-conifer- ingeneral, mixed stands including at least 25 percent of a deciduous...Balsam poplar Populus balsamifera Willow Salix spp. Tag alder Alnus rugosa Beaked hazel Cornus cornuta Rose Rosa spp. Staghorn sumac Rhus typhina Mountain
Berelowitch, Wladimir; Berelowitch, Wladimir; Bouquet, Olivier; Buseva-Davydova, Irina; Dmitriev, Mihail; Lavrov, Aleksandr; Lidov, Aleksej; Marchadier, Bernard; Martin, François-René; Medvedkova, Olga; Medvedkova, Olga; Nersesjan, Levon V.; Pivovarova, Nadežda; Preti, Monica; Živov, Victor
Les auteurs de cet ouvrage collectif se sont efforcés de saisir la notion de « Sainte Russie » dans sa longue durée. Bien avant son apparition dans les textes au XVIe siècle, elle faisait déjà partie de la tradition médiévale d’un transfert de sainteté, à partir des lieux saints (Jérusalem, Rome, Constantinople) vers le nouveau pays chrétien. Après la chute de Byzance en 1453, ce transfert prit en Russie une tournure particulière de sorte que, dès le XVIe siècle, un durcissement idéologique c...
Full Text Available When elementary aged Hmong children were resettled in St. Paul Public Schools after the closing of the Wat Tham Krabok refugee camp in Thailand, their families largely enrolled them in either a Transitional Language Center or a Language Academy program. This study reports on the perceptions teachers and educational assistants had about how well these programs met the needs of this unique population of newcomers. Findings show that the Transitional Language Centers were better able to ease the adjustment to school for the Hmong newcomers because of the safe, bilingual environment they created.
Full Text Available When elementary aged Hmong children were resettled in St. Paul Public Schools after the closing of the Wat Tham Krabok refugee camp in Thailand, their families largely enrolled them in either a Transitional Language Center or a Language Academy program. This study reports on the perceptions teachers and educational assistants had about how well these programs met the needs of this unique population of newcomers. Findings show that the Transitional Language Centers were better able to ease the adjustment to school for the Hmong newcomers because of the safe, bilingual environment they created.
Gillet, N.; Gloaguen, C.; Holcblat, A. [FRAMATOME ANP, 92 - Paris La Defence (France); Borsoi, L. [CEA Saclay (SEMT/DYN), 91 - Gif sur yvette (France); Adobes, A.; David, F. [Electricite de France (EDF/RD), 75 - Paris (France); Greiner, E. [Electricite de France (EDF CIPN-CM), 13 - Marseille (France); Pascal-Ribot, S. [CEA Cadarache, 13 - Saint Paul lez Durance (France); Gauchet, J.P. [Electricite de France (EDF/UTO/GVD), 93 - Noisy le Grand (France); Mercier, L. [Electricite de France (EDF/CAPE/GMC), 93 - Saint enis (France); Leomy, F. [FRAMATOME ANP, 71 - Chalon (France)
This document gathers the transparencies presented at the 6. technical session of the French nuclear energy society (SFEN) in June 2004. The main topic was the physics of steam generators: 1 - description (G. Paudroux, J.Y. Guena, M. Petit); 2 - thermo-hydraulics (A. Holcblat, F. David, S. Pascal-Ribot); 3 - mechanics (N. Gillet, L. Borsoi, A. Adobes); 4 - monitoring and maintenance means (J.P. Gauchet, L. Mercier, F. Leomy); 5 - replacement (C. Gloaguen, E. Greiner). (J.S.)
Luis Adrián Diaz
Full Text Available St. Louis encephalitis virus (SLEV, Flavivirus, Flaviviridae is an emerging mosquito-borne pathogen in South America, with human SLEV encephalitis cases reported in Argentina and Brazil. Genotype III strains of SLEV were isolated from Culex quinquefasciatus mosquitoes in Cordoba, Argentina in 2005, during the largest SLEV outbreak ever reported in South America. The present study tested the hypothesis that the recent, epidemic SLEV strain exhibits greater virulence in birds as compared with a non-epidemic genotype III strain isolated from mosquitoes in Santa Fe Province 27 years earlier. The observed differences in infection parameters between adult House sparrows (Passer domesticus that were needle-inoculated with either the epidemic or historic SLEV strain were not statistically significant. However, only the House sparrows that were infected with the epidemic strain achieved infectious-level viremia titers sufficient to infect Cx. spp. mosquitoes vectors. Furthermore, the vertebrate reservoir competence index values indicated an approximately 3-fold increase in amplification potential of House sparrows infected with the epidemic strain when pre-existing flavivirus-reactive antibodies were present, suggesting the possibility that antibody-dependent enhancement may increase the risk of avian-amplified transmission of SLEV in South America.
Politiques de lutte contre l'usage nocif de l'alcool et de réduction de ses méfaits au Liban (2013–17, American. University of Beirut). Évaluation des politiques de lutte contre l'usage nocif de l'alcool au Pérou et à Saint-Kitts-et-Nevis (2013–17, Uni- versidad Peruana Cayetano Heredia; Pan American. Health Organization).
changements apportés aux menus du centre de préparation de repas scolaires de Saint-. Kitts-et-Nevis, qui nourrit 800 enfants visés par l'intervention, ont eu pour effet d'intégrer. 19 850 kilos de fruits et de légumes dans les repas servis. • Des messages portant sur la nutrition, associés aux nouveaux menus, ont contribué.
3 janv. 2018 ... Saint-Kitts-et-Nevis et d'autres pays de l'est des Caraïbes connaissent des pénuries d'eau durant la saison sèche, ce qui empêche la production à longueur d'année. .... 50e assemblée annuelle de la Caribbean Food Crops Society, du 6 au 11 juillet 2014, St. Thomas, Îles Vierges des États-Unis.
Firsov Gennadiy Afanasyevich; Volchanskaya Аleksandra Vladimirovna; Tkachenko Kirill Gavriilovich
Picea glehnii (F. Schmidt) Mast. (the Glehns Spruce) is a rare endangered species of the Russian Far East, a plant included into the Red Book of the Russian Federation. This species is in need of protection In situ and Ex situ. The Glehns Spruce is introduced in general cultivation in 1877. In Saint Petersburg it became known after the expedition of F. Schmidt and P.P Glehn to Sakhalin Island (in 1860-1861). In hand-written general catalogues of living collections of Peter the Great Botanical...
Situation Reports--Afghanistan, Bahrein, Brazil, Ecuador, Indonesia, Iraq, Morocco, Paraguay, People's Democratic Republic of Yemen, Peru, Qatar, Saudi Arabia, Sri Lanka, St. Christopher/Nevis, Sudan, United Arab Emirates, Yemen Arab Republic.
International Planned Parenthood Federation, London (England).
Data relating to population and family planning in 17 foreign countries are presented in these situation reports. Countries included are Afghanistan, Bahrein, Brazil, Ecuador, Indonesia, Iraq, Morocco, Paraguay, People's Democratic Republic of Yemen, Peru, Qatar, Saudi Arabia, Sri Lanka, St. Christopher/Nevis, Sudan, United Arab Emirates, and…
Full Text Available Former trading post, colonial city, and French imperial capital turned provincial city in the wake of Africa’s independence movements, Saint-Louis in Senegal stands out among the cities of Sub-Saharan Africa. Inscribed on UNESCO’s World Heritage List in December of 2000, the city should be a cultural reference point on the nation’s tourist circuit. Over fifteen years after its inscription, the greater “Saintlouisian” (from Saint-Louis area is, however, faced with numerous difficulties and its tourism sector has been unable to lift the city out of its economic stagnation. This article analyzes Saint-Louis and the region in which is located as a tourist destination in the context of the Sahelian crisis by focusing on the heritage/tourism binary and its socioeconomic, spatial, and political consequences.
Joshi, U.; van der Sluijs, J.A.; Teule, G.J.; Pijpers, R.
Proteus syndrome is a rare, sporadic genetic disorder characterized by overgrowth of multiple different tissues in a mosaic pattern. It is associated with connective tissue nevi, epidermal nevi, disproportionate overgrowth of multiple tissues, vascular malformations, characteristic tumors, and
Full Text Available Based on original interviews with key protagonists and documentary research, the article examines the way in which the DJs who worked at the Saint forged a white gay aesthetic across the first half of the 1980s. A private party located in the East Village, New York, the Saint attracted a privileged white male crowd, and this group's position within the emerging culture of neoliberalism, along with the deepening impact of the AIDS epidemic, encouraged its spinners to sever their ties with sounds that were associated with blackness. However, if Saint DJs rejected a high proportion of records that were being released by New York's independents, and also snubbed Chicago house when it broke in 1985, their forging of an aesthetic that emphasised seamless transitions, often between records that contained similar sonic qualities, preempted the style of mixing that would be popularised in house music culture.
Clarke, Loren E; Warf, M B; Flake, Darl D; Hartman, Anne-Renee; Tahan, Steven; Shea, Christopher R; Gerami, Pedram; Messina, Jane; Florell, Scott R; Wenstrup, Richard J; Rushton, Kristen; Roundy, Kirstin M; Rock, Colleen; Roa, Benjamin; Kolquist, Kathryn A; Gutin, Alexander; Billings, Steven; Leachman, Sancy
Histopathologic examination is sometimes inadequate for accurate and reproducible diagnosis of certain melanocytic neoplasms. As a result, more sophisticated and objective methods have been sought. The goal of this study was to identify a gene expression signature that reliably differentiated benign and malignant melanocytic lesions and evaluate its potential clinical applicability. Herein, we describe the development of a gene expression signature and its clinical validation using multiple independent cohorts of melanocytic lesions representing a broad spectrum of histopathologic subtypes. Using quantitative reverse-transcription polymerase chain reaction (PCR) on a selected set of 23 differentially expressed genes, and by applying a threshold value and weighting algorithm, we developed a gene expression signature that produced a score that differentiated benign nevi from malignant melanomas. The gene expression signature classified melanocytic lesions as benign or malignant with a sensitivity of 89% and a specificity of 93% in a training cohort of 464 samples. The signature was validated in an independent clinical cohort of 437 samples, with a sensitivity of 90% and specificity of 91%. The performance, objectivity, reliability and minimal tissue requirements of this test suggest that it could have clinical application as an adjunct to histopathology in the diagnosis of melanocytic neoplasms. © 2015 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.
Rendu, William; Beauval, Cédric; Crevecoeur, Isabelle; Bayle, Priscilla; Balzeau, Antoine; Bismuth, Thierry; Bourguignon, Laurence; Delfour, Géraldine; Faivre, Jean-Philippe; Lacrampe-Cuyaubère, François; Tavormina, Carlotta; Todisco, Dominique; Turq, Alain; Maureille, Bruno
The bouffia Bonneval at La Chapelle-aux-Saints is well known for the discovery of the first secure Neandertal burial in the early 20th century. However, the intentionality of the burial remains an issue of some debate. Here, we present the results of a 12-y fieldwork project, along with a taphonomic analysis of the human remains, designed to assess the funerary context of the La Chapelle-aux-Saints Neandertal. We have established the anthropogenic nature of the burial pit and underlined the taphonomic evidence of a rapid burial of the body. These multiple lines of evidence support the hypothesis of an intentional burial. Finally, the discovery of skeletal elements belonging to the original La Chapelle aux Saints 1 individual, two additional young individuals, and a second adult in the bouffia Bonneval highlights a more complex site-formation history than previously proposed.
Pirtini Çetingül, Muge; Çetingül, Hasan E.; Herman, Cila
We have recently developed a dynamic infrared (IR) imaging system that provides accurate measurements of transient thermal response of the skin surface for characterizing lesions. Our hypothesis was that malignant pigmented lesions with increased proliferative potential generate quantifiable amounts of heat and possess an ability to reheat more quickly than the surrounding normal skin, thereby creating a marker of melanoma lesions vs. non-proliferative nevi. In our previous studies, we demonstrated that the visualization and measurement of the transient thermal response of the skin to a cooling excitation can aid the identification of skin lesions of different origin. This capability of distinguishing benign from malignant pigmented lesions is expected to improve the specificity and sensitivity for melanoma as well as other skin cancers, while decreasing the number of unnecessary biopsies. In this work, in order to quantify the transient thermal response with high accuracy, we present a processing framework on multimodal images, which includes a feature point (landmark) detection module, an IR image registration module that uses the resulting landmarks to correct involuntary body/limb motion and an interactive white-light image segmentation module to delineate the contours of the lesions. The proposed method is tested in a pilot patient study in which all the patients possess a pigmented lesion with a clinical indication for biopsy. After scanning, biopsying, and grading the lesions for malignant potential, we observe that the results of our approach match well with the biopsy results.
Environmental analysis report for the wind turbine array project at Gros-Morne in the municipalities of Saint-Maxime-du-Mont-Louis and Sainte-Madeleine-de-la-Riviere-Madeleine by Cartier Wind Energy (GM) Inc.; Rapport d'analyse environnementale pour le projet de parc eolien de Gros-Morne sur le territoire des municipalites de Saint-Maxime-du-Mont-Louis et de Sainte-Madeleine-de-la-Riviere-Madeleine par Cartier Energie Eolienne (GM) inc.
Talbot, D.; Theberge, M.C. [Quebec Ministere du Developpement durable, de l' Environnement et des Parcs, Quebec, PQ (Canada). Direction des evaluations environnementales; Rodrigue, M.C. (ed.)
The Quebec government has authorized the construction of both phases of the Gros-Morne project in Quebec's Gaspe Peninsula. The project represents 1 of 8 projects that were acquired by Hydro-Quebec Distribution as part of the utility's 2003 bidding process. It will involve the installation of 141 wind turbines for a total installed capacity of 211.5 MW. An environmental analysis was conducted in an effort to minimize environmental impact while striving to maximize local economic and social benefits. The installation will occur in 2 phases, with the first beginning in 2011 for 100.5 MW. The second phase has an expected commercial operation start date in 2012. Following the environmental assessment, Cartier Wind Energy was asked to examine the possibility of moving a number of wind turbines in order to mitigate the possible repercussions on two outfitting establishments located near the wind turbine parks, namely Camp de la Haute Madeleine and Pourvoirie Beausejour, as well as on vacationers residing inside or on the edge of these parks. Concern was expressed that the appearance of the wind turbines in the natural landscape of the outfitting establishments could have an adverse impact on their appeal. In addition, due to the peace and tranquility of vacation sites and because the noise produced by wind turbines differs from that normally found on these sites, this noise could be audible for vacationers living inside or on the edge of wind turbine parks and result in a significant inconvenience. The impact on birds and bats was difficult to evaluate because of the limited knowledge available. The proponent was also asked to examine the possibility of optimizing the location of the wind turbines and the access roads on the edge of a nature reserve's boundaries, to prevent potential repercussions. refs., tabs.
Dorizas, Andrew S; Nassar, Amer H; Goldberg, David J
We determine if the use of Multispectral Digital Skin Lesion Analysis for the evaluation of nevi in children and possible detection of malignancies. Evidence gathered from a pivotal study involving 1,383 patients with 1,831-pigmented lesions. The isolated use of the pediatric population within this study was used to determine the specificity and sensitivity of such a device with comparison to a dermatologists evaluation. For all lesions from the assessed pediatric population the biopsy ratio was equivalent for the Multispectral Digital Skin Lesion Analysis device as for the dermatologists when performing as independent reviewers. Furthermore analyzed data suggests that dermatologists who incorporate the Multispectral Digital Skin Lesion Analysis device perform better than they would independently or if they were to follow the device blindly without incorporating their own judgment. An approach that integrates automated imaging technology like the Multispectral Digital Skin Lesion Analysis device, along with another diagnostic aid, with the end result being cost-effective, easy to use by even non-experts and comforting for the pediatric patient is likely to compete to be the new gold standard in successful early diagnosis and management of melanoma.
Tanya Long Bennett
Full Text Available An analysis of Galway Kinnell's poems "The Fly, "Saint Francis and the Sow," and "Blackberry Eating," reveals Kinnell's treatment of the concept of logopoeia, a term coined by Ezra Pound to describe a particular use of language in poetry. Pound defined the term through illustration in the poems of Mina Loy and Jules Laforgue; it refers to the use of abstract, ironic vocabulary, which generates an objective, anti-sentimental, and satirical poetic stance. Kinnell, who adopts a distinctly Romantic role as a poet, nonetheless employs key aspects of logopoeia in order to adapt the Romantic ideology to the contemporary reader. Through a unique integration of Romantic sentiment with the intellectually playful, logopoeic use of diction, Kinnell produces poetry that both exploits and celebrates language and its multiple levels of meaning as well as addressing the painful wounds of the contemporary psych.
Project to construct the Des Moulins wind turbine array at Thetford mines, Kinnear's Mills and Saint-Jean-de-Brebeuf : public inquiry report; Projet d'amenagement du parc eolien Des Moulins a Thetford Mines, Kinnear's Mills et Saint-Jean-de-Brebeuf : rapport d'enquete et d'audience publique
3Ci Energie Eolienne is planning to develop a 156 MW wind turbine array across 3 municipalities in Quebec, notably Kinnear's Mills, Saint-Jean-de-Brebeuf and Thetford Mines. The project will involve the installation of 78 Enercon E-82 turbines each with a 2 MW capacity and a total height of 139 metres. The proposed development was subject to an environmental evaluation process and public consultation. Quebec's environmental public hearing board held a public hearing on the draft development of the project to hear the concerns and views of the public and stakeholders. The hearing focused on a number issues, such as reasons for the project, its location and socio-economic impacts. The primary concern was the environment and the effect of the wind turbines on fauna, flora and the quality of life. While supporters of the project, including the mayor, farmers and wood-lot owners, welcomed the large investment in the region, opponents were concerned that the turbines will disfigure the landscape, cause noise, interfere with telecommunication signals, disrupt wildlife, intrude on the quality of life and lower real-estate values. Critics also argued that the wind project will offer few benefits to local communities once the initial construction phase is over. Having considered the views of both proponents and opponents, the Board determined that the project is acceptable in terms of sustainable development. However, the project will require certain follow-up regarding the mortality of birds and bats as well as corrective measures to mitigate any interference with telecommunication signals.13 refs., 3 tabs., 2 figs.
This volume contains lectures given at the Saint-Flour Summer School of Probability Theory during 17th Aug. - 3rd Sept. 1998. The contents of the three courses are the following: - Continuous martingales on differential manifolds. - Topics in non-parametric statistics. - Free probability theory. The reader is expected to have a graduate level in probability theory and statistics. This book is of interest to PhD students in probability and statistics or operators theory as well as for researchers in all these fields. The series of lecture notes from the Saint-Flour Probability Summer School can be considered as an encyclopedia of probability theory and related fields.
International audience; Within thirty years, the small island of Saint-Barthelemy (25 km²) is out of its secular isolation to be among major luxury tourism destinations in the world. In this study, the idea is to identify structural element and different cyclical factors that help to understand Saint-Barthelemy tourism situation. The small size of the territory itself can be seen as a fundamental handicap or, conversely, as a considerable asset. Everything depends on development project. It i...
Full Text Available By studying objects from the former collection of the French collector Gaston de Saint-Maurice (1831-1905 now in the Louvre and the Musée des Arts décoratifs in Paris, this article elucidates different aspects of the taste for reuse of architectural elements and decorative artefacts in the 19th century. Known for his collection of Islamic art (acquired by the South Kensington Museum in 1883, Saint-Maurice also collected European decorative arts showing his taste for historical decors. This article also raises the question of the appropriation of such artefacts by museums today.
Albury, W R; Weisz, G M
A fifteenth-century Florentine altarpiece painted by the Pollaiuolo brothers, Antonio (1433-1498) and Piero (1443-1496), shows three saints with evident deformities of the hands and feet. The pathologies concerned are tentatively identified, and various rationales for their presence in the painting are discussed. Of particular importance is the location of the altarpiece in a chapel which houses the tomb of the Cardinal of Portugal, Prince James of Lusitania (1433-1459). It is argued that both the artistic style of the day and the religious symbolism of the Cardinal's funeral chapel contributed to the artists' decision to portray the saints with deformities. An unnatural curvature of the fifth finger was apparently considered elegant in fifteenth-century paintings, and the depiction of bare feet with hallux valgus gave them a shape which approximated and could have been caused by fashionable pointed shoes. But in addition, deformities in religious art could be symbolic of suffering and martyrdom, a theme which the Cardinal's chapel emphasised in a number of ways. It is suggested therefore that the Pollaiuolo altarpiece reconciles these two disparate factors, portraying genuine deformities in a way that was artistically stylish and symbolically meaningful.
Mémoire du travail et des expositions professionnelles aux cancérogènes Work account and occupational exposures to carcinogens. Survey in Seine-Saint-Denis (France Memoria del trabajo y de las exposiciones profesionales a agentes cancerígenos. Encuesta en Seine-Saint-Denis (Francia
Full Text Available Selon les estimations officielles, en 2000 environ 32 millions de travailleurs européens (de l’Europe des 15 étaient exposés à des cancérogènes. Depuis 2002, considérant la maladie comme « événement-sentinelle » pour la connaissance des activités de travail exposant aux cancérogènes, le Groupement d’intérêt scientifique sur les cancers d’origine professionnelle (GISCOP93 mène une enquête permanente auprès de patients atteints de cancer en Seine Saint Denis (France. S’appuyant sur les récits recueillis auprès des patients et sur l’expertise des spécialistes en matière d’exposition, une démarche d’analyse et de classement des activités exposées a été réalisée pour l’élaboration d’un répertoire des activités de travail en présence de produits/procédés cancérogènes. L’objectif de cet article est de mettre en perspective cette nouvelle base de données par rapport à quelques sources d’information concernant l’exposition professionnelle aux cancérogènes, déjà disponibles en ligne, en montrant l’apport d’une méthode de recueil d’information fondée sur l’expérience et la parole des travailleurs.According to official estimates, in the year 2000, approximately 32 million European workers (in Europe 15 were exposed to carcinogens. Since 2002, considering the disease as a "sentinel-event" for understanding the work activities that expose workers to carcinogens, the GISCOP93 research group has been carrying out an ongoing survey on patients with cancer in Seine-Saint-Denis (France. Based on the patients’ narratives and on the expertise of exposure hazard specialists, an analysis and classification of the exposed working activities was carried out to build a new database of work activities in the presence of carcinogenic products/processes. The aim of this article is to present this database in relation to some other sources of information on occupational exposure to carcinogens
Correlation between dermoscopic and histopathological diagnoses of atypical nevi in a dermatology outpatient clinic of the Medical School of São José do Rio Preto, SP, Brazil Correlação entre os diagnósticos dermatoscópico e histopatológico de nevos atípicos no ambulatório de dermatologia da Faculdade de Medicina de São José do Rio Preto, SP, Brasil
João Roberto Antonio
Full Text Available BACKGROUND: The incidence of cutaneous melanoma is increasing worldwide. Since it is an aggressive neoplasm, it is difficult to treat in advanced stages; early diagnosis is important to heal the patient. Melanocytic nevi are benign pigmented skin lesions while atypical nevi are associated with the risk of developing melanoma because they have a different histological pattern than common nevi. Thus, the clinical diagnosis of pigmented lesions is of great importance to differentiate benign, atypical and malignant lesions. Dermoscopy appeared as an auxiliary test in vivo, playing an important role in the diagnosis of pigmented lesions, because it allows the visualization of structures located below the stratum corneum. It shows a new morphological dimension of these lesions to the dermatologist and allows greater diagnostic accuracy. However, histopathology is considered the gold standard for the diagnosis. OBJECTIVES: To establish the sensitivity and specificity of dermoscopy in the diagnosis of pigmented lesions suspected of malignancy (atypical nevi, comparing both the dermatoscopic with the histopathological diagnosis, at the Dermatology Service of the outpatient clinic of Hospital de Base, São José do Rio Preto, SP. METHODS: Analysis of melanocytic nevi by dermoscopy and subsequent biopsy on suspicion of atypia or if the patient so desires, for subsequent histopathological diagnosis. RESULTS: Sensitivity: 93%. Specificity: 42%. CONCLUSIONS: Dermoscopy is a highly sensitive method for the diagnosis of atypical melanocytic nevi. Despite the low specificity with many false positive diagnoses, the method is effective for scanning lesions with suspected features of malignancy. FUNDAMENTOS: A incidência do melanoma cutâneo tem aumentado mundialmente e, por ser uma neoplasia agressiva de difícil tratamento em estágios avançados, o diagnóstico precoce é fundamental para cura do paciente. Os nevos melanocíticos são lesões pigmentadas
The law from December 30, 1991, precisely defines 3 axes of researches for the management of high level and long-lived radioactive wastes: separation/transmutation, surface storage and underground disposal. A global evaluation report about these researches is to be supplied in 2006 by the French government to the Parliament. A first synthesis of the knowledge gained after 14 years of research has led the national commission of the public debate (CNDP) to organize a national debate about the general options of management of high-level and long-lived radioactive wastes before the 2006 date line. The debate comprises 4 public hearings (September 2005: Bar-le-Duc, Saint-Dizier, Pont-du-Gard, Cherbourg), 12 round-tables (October and November 2005: Paris, Joinville, Caen, Nancy, Marseille), a synthesis meeting (December 2005, Dunkerque) and a closing meeting (January 2006, Lyon). This document is the synthesis of the debates of the second public hearing at Saint-Dizier. This meeting gathers representatives of the different actors of the nuclear industry, ministers, public authorities, non governmental organizations who argue the questions asked by peoples from the audience. The topics concern the safety aspects of waste facilities, in particular according to the studies carried out at the Bure site, the different categories of wastes and the future wastes that will be generated by the dismantling of nuclear facilities etc. (J.S.)
Full Text Available The "Triptych of the Life of Christ", belonging to the church of Saint John, the Baptist, in Tomar (Portugal, is dated from the early 16th century and attributed to the workshop of Quentin Metsys. When the current intervention of conservation and restoration started, it featured large retouching, significantly altered, which posed several ethical questions. What to do with these retouchings was the main problem, for which a solution was not evident. They must be assumed as part of the triptych's history and kept, despite the problems? Or should they be removed? All or just some of them? Ultimately, how to respect the authenticity, memory and profession's ethics? This is what we intend to discuss.
Full Text Available FUNDAMENTOS - Os nevos melanocíticos adquiridos são observados em grande parte da população e o resultado da sua excisão, dependendo da localização, extensão e fatores inerentes ao paciente, pode ser insatisfatório. OBJETIVO - Avaliar o uso do laser Erbium: YAG no tratamento de nevos melanocíticos adquiridos MÉTODOS - Foram selecionados nove pacientes, seis homens e três mulheres, brancos, com idade entre 20 e 60 anos e desejo de remover um nevo melanocítico composto no tronco. Metade do nevo foi tratada com laser, e a outra metade foi utilizada como controle. Após um mês da aplicação, foram avaliados a cicatrização, o resultado estético e a persistência de células névicas e melanina. RESULTADOS - Houve rápida cicatrização e ótimo resultado estético, no entanto, o exame histopatológico demonstrou a permanência de células névicas e melanina em sete e em nove das amostras examinadas, respectivamente. CONCLUSÃO - A utilização do laser Erbium:YAG, com os parâmetros utilizados neste estudo, não foi capaz de destruir completamente as células névicas melanocíticas e a melanina, não sendo, portanto, recomendada para o tratamento dessas lesões, dada a possibilidade de transformação maligna futura.BACKGROUND- Acquired melanocytic nevi are commonly found and the result of their excision may not be satisfactory depending on their location, extension and factors associated to the patient. OBJECTIVE - To evaluate the use of Erbium:YAG laser in treatment of acquired melanocytic nevi. METHOD - Nine white-skinned patients were selected, six men and three women with aged 20-60 years. All desired to remove one compound acquired melanocytic nevus on the trunk. Half of the nevi was treated with Erbium YAG laser while the remaining were used as control. One month after application, healing, aesthetic results and persistence of melanocytic cells and melanin were evaluated. RESULTS - All patients presented fast healing and
Chaplin, Eddie; Craig, Tom; McCarthy, Jane; Bouras, Nick
Introduction: This article introduces the SAINT (Self-Assessment and INTervention), a guided self-help intervention for the treatment of mild depression in people with intellectual disabilities. Method: The study used a single-case experimental design and adopted quality frameworks specific to the approach to describe the participants and to…
from Cape Virgins (52°20’S., 68°?TW.) to Cape Espiritu Santo (52°40’S., 68°36’W.) Territorio Nacional la Tierra del Fuego in Argentina; and east...SAINT SAINT SAINT SAINT SAINT SAINT SAINT DOMINICAN AZUA RAORUCO PARAHONA DAJARON DISTRITO NACIONAL DUARTF EL SFIRO ESPAILLAT...Islands) Shag Island Sharjah Shetland Islands Sicily (Island) Silhouette Island Sinklang Snares Islands Soberania , Plazas De Socotra (Island
Schwartz, Heather L.; Karoly, Lynn A.
In 2008, the Minnesota Early Learning Foundation created the Saint Paul Early Childhood Scholarship Program, a pilot program to provide families with scholarships to cover the cost of high-quality early childhood education (ECE) programs. Although there is a large body of research about the benefits of preschool specifically and early learning…
Griffiths, Casey Paul; Esplin, Scott C.; Randall, E. Vance
In recent years the educational programs of the Church of Jesus Christ of Latter-day Saints (LDS) have received praise for their role in the high rates of religiosity and denominational retention among their youth. This study offers a historical summary of the efforts of LDS to develop the most effective methods of engaging their youth in…
van Aelst, J.J.
After the enclosure of the Saint-Agnes convent at Maaseik in 1430, the regular canonesses had to learn how to live within the claustrum. They received support from at least two Carthusian monks: James of Gruitrode, prior of the charterhouse in Liège, and Denys the Carthusian from the charterhouse of
The design and manufacture of the pulse amplifier required for the 3 MeV test stand chopper has been attributed to FID gmbh which is a branch of FID Technology of Saint Petersburg. This visit has been made to monitor the status of the supply.