SAHA-S thermodynamic model of solar plasma
International Nuclear Information System (INIS)
Gryaznov, V.K.; Iosilevskiy, I.L.; Fortov, V.E.; Starostin, A.N.; Roerich, V.K.; Baturin, V.A.; Ayukov, S.V.
2013-01-01
The model SAHA-S based on the chemical picture for the equation of state of the solar plasma is presented. The effects of Coulomb interaction, exchange and diffraction effects, free electron degeneracy, relativistic corrections, radiation pressure contributions are taken into account. The solar model based on SAHA-S taking into account extended element composition and variation of heavy element abundance is represented and discussed. The comparison of the SAHA-S equation of state data for a hydrogen plasma with the results of other models applicable to the description of the solar plasma equation of state and the results obtained with the first principle methods are demonstrated and discussed. (copyright 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Abhijit Saha. Articles written in Resonance – Journal of Science Education. Volume 9 Issue 7 July 2004 pp 90-92 Book Review. The Story of Quantum Theory · Abhijit Saha · More Details Fulltext PDF ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Banishree Saha. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Abhishek Saha. Articles written in Resonance – Journal of Science Education. Volume 7 Issue 2 February 2002 pp 86-89 Classroom. Sums of Power of the Primitive Roots of a Prime · Abhishek Saha · More Details Fulltext PDF ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Babita Saha. Articles written in Resonance – Journal of Science Education. Volume 21 Issue 12 December 2016 pp 1093-1104 General Article. Mycorrhiza: The Oldest Association Between Plant and Fungi · Jagnaseni Barman Aveek Samanta Babita Saha Siraj ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. B Saha. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 11 November 1999 pp 65-71 Classroom. Inadequacy of Water Band Movement Technique for Kinetic Interpretation of RCOOH–NaHCO3 Reaction · P Sahoo B Saha.
Indian Academy of Sciences (India)
Home; Journals; Sadhana. Chandan Saha. Articles written in Sadhana. Volume 39 Issue 4 August 2014 pp 843-858. Give-and-take based peer-to-peer content distribution networks · Saurabh Aggarwal Joy Kuri Chandan Saha · More Details Abstract Fulltext PDF. Content Distribution Networks (CDNs) are widely used to ...
Indian Academy of Sciences (India)
Home; Journals; Sadhana. Asish Saha. Articles written in Sadhana. Volume 29 Issue 3 June 2004 pp 315-327. Damage assessment in structure from changes in static parameter using neural networks · Damodar Maity Asish Saha · More Details Abstract Fulltext PDF. Damage to structures may occur as a result of normal ...
Indian Academy of Sciences (India)
Home; Journals; Pramana – Journal of Physics. Saha Aparna. Articles written in Pramana – Journal of Physics. Volume 86 Issue 4 April 2016 pp 861-871 Regular. Ionization of Rydberg atoms by the kicks of half-cycle pulses · Chatterjee Supriya Saha Aparna Talukdar B · More Details Abstract Fulltext PDF. We present a ...
Indian Academy of Sciences (India)
Home; Journals; Sadhana. S SAHA. Articles written in Sadhana. Volume 42 Issue 9 September 2017 pp 1459-1471. Influence of yielding base and rigid base on propagation of Rayleigh-type wave in a viscoelastic layer of Voigt type · S SAHA A CHATTOPADHYAY K C MISTRI A K SINGH · More Details Abstract Fulltext PDF.
Indian Academy of Sciences (India)
Home; Journals; Sadhana. S Saha. Articles written in Sadhana. Volume 27 Issue 6 December 2002 pp 613-630. Reflection of quasi-P and quasi-SV waves at the free and rigid boundaries of a fibre-reinforced medium · A Chattopadhyay R L K Venkateswarlu S Saha · More Details Abstract Fulltext PDF. The propagation of ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. M N Saha. Articles written in Resonance – Journal of Science Education. Volume 3 Issue 5 May 1998 pp 84-96 Classics. The Origin of Mass in Neutrons and Protons · M N Saha · More Details Fulltext PDF ...
Indian Academy of Sciences (India)
Email: tanusri@bose.res.in. Tanusri Saha-Dasgupta, SN Bose National Centre for Basic Sciences, Kolkata, elected to Fellowship in 2010. Saha-Dasgupta works in the area of computational condensed matter physics. She is a recipient of Swarnajayanti Fellowship, and the MRSI-ICSC Superconductivity & Materials Science ...
Indian Academy of Sciences (India)
Home; Journals; Pramana – Journal of Physics. M Saha Sarkar. Articles written in Pramana – Journal of Physics. Volume 57 Issue 1 July 2001 pp 165-169 Contributed Papers : Nuclear spectroscopy. Level structures ofMo – A comparative study · J M Chatterjee M Saha Sarkar S Bhattacharya P Banerjee S Sarkar R P Singh ...
Eesti keele kui teise keele oskuse riiklik standard üldhariduses / Silvi Vare
Vare, Silvi, 1939-
2004-01-01
Eesti keele kui teise keele riikliku standardiga seotud probleemidest, eesti keeleõpetuse tegelikust tasemest Eesti üldhariduskoolides. Vene gümnaasiumi lõpetajate eesti keele oskusest. Sisaldab tabeleid
Saha equation in Rindler space
Indian Academy of Sciences (India)
Sanchari De
2017-05-31
May 31, 2017 ... scenario, the flat local geometry is called the Rindler space. For an illustration, let us consider two reference ... the local acceleration of the frame. To investigate Saha equation in a uniformly acceler- ... the best of our knowledge, the study of Saha equa- tion in Rindler space has not been reported earlier.
Maximilien Brice
2009-01-01
Mr Bikash Sinha, Director of SAHA & VECC and Prof. Rolf Heuer, Director general of CERN, sign a collaboration agreements between SAHA (Saha Institute of Nuclear Physics), VECC (Variable Energy Cyclotron Centre), India and CERN ISOLDE.
Indian Academy of Sciences (India)
Marker-assisted introgression of opaque2 allele for rapid conversion of elite hybrids into quality protein maize · FIROZ HOSSAIN VIGNESH MUTHUSAMY NEHA PANDEY ASHISH K. VISHWAKARMA AANCHAL BAVEJA RAJKUMAR U. ZUNJARE NEPOLEAN THIRUNAVUKKARASU SUPRADIP SAHA KANCHIKERI M.
Indian Academy of Sciences (India)
Home; Journals; Bulletin of Materials Science. NABANITA SAHA. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 55. Green synthesis of silver nanoparticles and biopolymer nanocomposites: a comparative study on physico-chemical, antimicrobial and anticancer activity · RAMASUBBA ...
Indian Academy of Sciences (India)
RITABRATA SAHA. Articles written in Indian Academy of Sciences Conference Series. Volume 1 Issue 1 December 2017 pp 67-75 Proceedings of the Conference on Perspectives in Nonlinear Dynamics - 2016. Flow dynamic study of a single-phase square NCL using recurrence plot and recurrence quantification.
Indian Academy of Sciences (India)
SANJOY SAHA. Articles written in Journal of Chemical Sciences. Volume 130 Issue 1 January 2018 pp 9. Physico-chemical characterization and biological studies of newly synthesized metal complexes of an Ionic liquid-supported Schiff base: 1-{2-[(2-hydroxy-5-bromobenzylidene)amino]ethyl}-3- ethylimidazolium ...
Indian Academy of Sciences (India)
Home; Journals; Journal of Earth System Science. Dipankar Saha. Articles written in Journal of Earth System Science. Volume 123 Issue 6 August 2014 pp 1335-1347. Geomorphologic, stratigraphic and sedimentologic evidences of tectonic activity in Sone–Ganga alluvial tract in Middle Ganga Plain, India · Sudarsan Sahu ...
Indian Academy of Sciences (India)
Home; Journals; Pramana – Journal of Physics. UTTIYOARNAB SAHA. Articles written in Pramana – Journal of Physics. Volume 90 Issue 4 April 2018 pp 46 Research Article. Neutron radiation damage studies in the structural materials of a 500 MWe fast breeder reactor using DPA cross-sections from ENDF/B-VII.1.
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Sayanti Saha. Articles written in Resonance – Journal of Science Education. Volume 10 Issue 3 March 2005 pp 28-34 General Article. “That which we call a rose by any other name would smell as sweet”: How the Nose knows! - Nobel Prize in Physiology or ...
Indian Academy of Sciences (India)
Home; Journals; Journal of Chemical Sciences. KOUSHIK SAHA. Articles written in Journal of Chemical Sciences. Volume 128 Issue 7 July 2016 pp 1025-1032 Regular Article. Reactivity of [Cp*Mo(CO)₃Me] with chalcogenated borohydrides Li[BH₂E₃] and Li[BH₃EFc] (Cp* = (ŋ⁵-C₅Me₅); E = S, Se or Te; ...
Eesti keel koos teiste läänemeresoome keeltega ja germaani keeled Hiinast vaadatuna / Ago Künnap
Künnap, Ago, 1941-
2009-01-01
Arvustus: Gao, Jingyi. [Hiina keel ja Põhja-Euroopa keeled. Hiina keele ning uurali keelte ja indo-euroopa keelte ühiste allikate alased avastused ja uurimused. Peking : Hiina Ühiskonnateaduste Kirjastus, 2008
Directory of Open Access Journals (Sweden)
Valve-Liivi Kingisepp
2015-10-01
Full Text Available Kirjutise autor töötas aastail 1988–1992 eesti keele lektorina Oulu ülikoolis ja selgitab, kuidas toimus 1980. aastatel Moskva kaudu lektorite tööle suunamine, missuguseid ainekursusi tuli lugeda, õpetada, kuidas võtsid üliõpilased pakutut vastu, missuguseks kujunes teadustöö kateedris, lektorite seminaridel, ettekanded, kaastöö väljaannetele, eesti keele päeva korraldamine jm. Samas iseloomustatakse lektori tegevust väljaspool ülikooli Eesti iseseisvumisliikumise ajal, meeldejäävaid kokkupuuteid kohalikega, intensiivset õpetustegevust rahvaülikoolides, eesti keele ja kultuuri tutvustamist suveülikoolides, koolides.
Indian Academy of Sciences (India)
Home; Journals; Sadhana. SUBHAS CHANDRA SAHA. Articles written in Sadhana. Volume 41 Issue 5 May 2016 pp 549-559. A comparative study of multiple regression analysis and back propagation neural network approaches on plain carbon steel in submerged-arc welding · ABHIJIT SARKAR PRASENJIT DEY R N ...
Rein Veidemanni romaan vene keeles
2015-01-01
Kirjastus KPD on välja andnud vene keeles Rein Veidemanni 2012. aastal ilmunud romaani "Tund enne igavikku". Marina Tervoneni tõlkes ilmunud teos kannab vene keeles pealkirja "Вечный университет"
4 veebirakendust uue keele õppeks / Vaiko Mäe
Mäe, Vaiko
2015-01-01
Uue keele omandamine on muutunud tänu mobiilirakendustele kättesaadavamaks, interaktiivsed keeleõppematerjalid võimaldavad õpet sõltumata ajast. Veebiportaal http://educatorstechnology.com on järjestanud parimad veebilehed uue keele õppeks
Dual-keel electrodynamic maglev system
Energy Technology Data Exchange (ETDEWEB)
Jianlang, He [Argonne National Lab., IL (United States); Rote, D M [Argonne National Lab., IL (United States); Zian, Wang [Argonne National Lab., IL (United States); Coffey, H T [Argonne National Lab., IL (United States)
1996-12-31
This paper introduces a new concept for an electrodynamic-suspension maglev system that has a dual-keel arrangement. Each keel consists of a row of superconducting magnets aboard the vehicle. The keels move in troughs in the guideway that are each lined with pairs of figure-eight-shaped null-flux coils. Each pair of null-flux coils is cross-connected to produce null-flux suspension and guidance force. The cross-connected figure-eight null-flux coils in each trough are also energized by a three-phase power supply to produce propulsive force. Preliminary analysis shows that the new system has many advantages over other EDS systems in terms of system performance and dynamic stability. (orig.)
Professor Jacques Cortes prantsuse keele lektoraadis
2000-01-01
Juuni alguses külastas filoloogiateaduskonna romaani-germaani filoloogia osakonda Roueni ülikooli professor Jacques Cortes (Prantsusmaa). Ta korraldas 4. õa üliõpilastele prantsuse keele intensiivkursuse ja võttis vastu eksami ning kohtus prantsuse keele lektoraadi õppejõududega : [täistekst
Saha's ionization equation for high Z elements
International Nuclear Information System (INIS)
Godwal, B.K.; Sikka, S.K.
1977-01-01
Saha's ionization equation has been solved for high Z elements with the aim of providing input for opacity calculations. Results are presented for two elements, tungsten and uranium. The ionization potentials have been evaluated using the simple Bhor's formula with suitable effective charges for ions. The reliability of the free electron density, ion concentrations, etc., obtained from the Saha's equation solutions has been checked by comparing the P and E computed from them with those given by the Thomas-Fermi-Dirac equation of state. The agreement between the two is good from temperatures above 0.2 keV. (author)
On the Saha Ionization Equation
Indian Academy of Sciences (India)
Abstract. We revisit the Saha Ionization Equation in order to highlightthe rich interdisciplinary content of the equation thatstraddles distinct areas of spectroscopy, thermodynamics andchemical reactions. In a self-contained discussion, relegatedto an appendix, we delve further into the hidden message ofthe equation in terms ...
Early Onset of Laying and Bumblefoot Favor Keel Bone Fractures
Gebhardt-Henrich, Sabine G.; Fröhlich, Ernst K. F.
2015-01-01
Simple Summary Numerous studies have documented a high prevalence of keel bone fractures in laying hens. In this longitudinal study, 80 white and brown laying hens were regularly checked for keel bone deviations and fractures while egg production was individually monitored. About 62% of the hens had broken keel bones at depopulation. More new fractures occurred during the time when laying rates were highest. Hens with broken keel bones at depopulation had laid their first egg earlier than hens with intact keel bones. All birds with bumblefoot on both feet had a fracture at depopulation. Abstract Numerous studies have demonstrated influences of hybrid, feed, and housing on prevalence of keel bone fractures, but influences of behavior and production on an individual level are less known. In this longitudinal study, 80 white and brown laying hens were regularly checked for keel bone deviations and fractures while egg production was individually monitored using Radio Frequency Identification (RFID) from production until depopulation at 65 weeks of age. These focal birds were kept in eight pens with 20 hens per pen in total. About 62% of the hens had broken keel bones at depopulation. The occurrence of new fractures was temporally linked to egg laying: more new fractures occurred during the time when laying rates were highest. Hens with fractured keel bones at depopulation had laid their first egg earlier than hens with intact keel bones. However, the total number of eggs was neither correlated with the onset of egg laying nor with keel bone fractures. All birds with bumblefoot on both feet had a fracture at depopulation. Hens stayed in the nest for a longer time during egg laying during the ten days after the fracture than during the ten days before the fracture. In conclusion, a relationship between laying rates and keel bone fractures seems likely. PMID:26633520
Teine muutuva keele ettekandepäev / Helle Metslang, Ilona Tragel
Metslang, Helle, 1950-
2007-01-01
Teisest muutuva keele ettekandepäevast Tartus, 3.11.2006. Muutuva keele ettekandepäevi korraldab ETF-i kahe grandiprojekti töörühm: "Eesti keele grammatilise süsteemi muutumine ja selle põhjused : keelemuutuste analüüs kasutuskontekstis" (Tartu Ülikool, grandihoidja Ilona Tragel) ja "Eesti keele grammatika ja sõnavara dünaamika 1990-2000. aastatel" (Tallinna Ülikool, grandihoidja Helle Metslang)
The HDAC inhibitor SAHA does not rescue CFTR membrane expression in Cystic Fibrosis.
Bergougnoux, Anne; Petit, Aurélie; Knabe, Lucie; Bribes, Estelle; Chiron, Raphaël; De Sario, Albertina; Claustres, Mireille; Molinari, Nicolas; Vachier, Isabelle; Taulan-Cadars, Magali; Bourdin, Arnaud
2017-07-01
The development of suitable Cystic Fibrosis (CF) models for preclinical bench tests of therapeutic candidates is challenging. Indeed, the validation of molecules to rescue the p.Phe508del-CFTR channel (encoded by the Cystic Fibrosis Transmembrane conductance Regulator gene carrying the p.Phe508del mutation) requires taking into account their overall effects on the epithelium. Suberoylanilide Hydroxamic Acid (SAHA), a histone deacetylase inhibitor (HDACi), was previously shown to be a CFTR corrector via proteostasis modulation in CFTR-deficient immortalized cells. Here, we tested SAHA effects on goblet cell metaplasia using an ex vivo model based on the air-liquid interface (ALI) culture of differentiated airway epithelial cells obtained by nasal scraping from CF patients and healthy controls. Ex vivo epithelium grew successfully in ALI cultures with significant rise in the expression of CFTR and of markers of airway epithelial differentiation compared to monolayer cell culture. SAHA decreased CFTR transcript and protein levels in CF and non-CF epithelia. Whereas SAHA induced lysine hyperacetylation, it did not change histone modifications at the CFTR promoter. SAHA reduced MUC5AC and MUC5B expression and inhibited goblet epithelial cell differentiation. Similar effects were obtained in CF and non-CF epithelia. All the effects were fully reversible within five days from SAHA withdrawal. We conclude that, ex vivo, SAHA modulate the structure of airway epithelia without specific effect on CFTR gene and protein suggesting that HDACi cannot be useful for CF treatment. Copyright © 2017. Published by Elsevier Ltd.
SAHA-induced TRAIL-sensitisation of Multiple Myeloma cells is enhanced in 3D cell culture.
Arhoma, A; Chantry, A D; Haywood-Small, S L; Cross, N A
2017-11-15
Multiple Myeloma (MM) is currently incurable despite many novel therapies. Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) is a potential anti-tumour agent although effects as a single agent are limited. In this study, we investigated whether the Histone Deacetylase (HDAC) inhibitor SAHA can enhance TRAIL-induced apoptosis and target TRAIL resistance in both suspension culture, and 3D cell culture as a model of disseminated MM lesions that form in bone. The effects of SAHA and/or TRAIL in 6 Multiple Myeloma cell lines were assessed in both suspension cultures and in an Alginate-based 3D cell culture model. The effect of SAHA and/or TRAIL was assessed on apoptosis by assessment of nuclear morphology using Hoechst 33342/Propidium Iodide staining. Viable cell number was assessed by CellTiter-Glo luminescence assay, Caspase-8 and -9 activities were measured by Caspase-Glo™ assay kit. TRAIL-resistant cells were generated by culture of RPMI 8226 and NCI-H929 by acute exposure to TRAIL followed by selection of TRAIL-resistant cells. TRAIL significantly induced apoptosis in a dose-dependent manner in OPM-2, RPMI 8226, NCI-H929, U266, JJN-3 MM cell lines and ADC-1 plasma cell leukaemia cells. SAHA amplified TRAIL responses in all lines except OPM-2, and enhanced TRAIL responses were both via Caspase-8 and -9. SAHA treatment induced growth inhibition that further increased in the combination treatment with TRAIL in MM cells. The co-treatment of TRAIL and SAHA reduced viable cell numbers all cell lines. TRAIL responses were further potentiated by SAHA in 3D cell culture in NCI-H929, RPMI 8226 and U266 at lower TRAIL + SAHA doses than in suspension culture. However TRAIL responses in cells that had been selected for TRAIL resistance were not further enhanced by SAHA treatment. SAHA is a potent sensitizer of TRAIL responses in both TRAIL sensitive and resistant cell lines, in both suspension and 3D culture, however SAHA did not sensitise TRAIL-sensitive cell
International Nuclear Information System (INIS)
Zhang, Jingjie; Ouyang, Weiming; Li, Jingxia; Zhang, Dongyun; Yu, Yonghui; Wang, York; Li, Xuejun; Huang, Chuanshu
2012-01-01
Suberoylanilide hydroxamic acid (SAHA) inhibiting cancer cell growth has been associated with its downregulation of cyclin D1 protein expression at transcription level or translation level. Here, we have demonstrated that SAHA inhibited EGF-induced Cl41 cell transformation via the decrease of cyclin D1 mRNA stability and induction of G0/G1 growth arrest. We found that SAHA treatment resulted in the dramatic inhibition of EGF-induced cell transformation, cyclin D1 protein expression and induction of G0/G1 growth arrest. Further studies showed that SAHA downregulation of cyclin D1 was only observed with endogenous cyclin D1, but not with reconstitutionally expressed cyclin D1 in the same cells, excluding the possibility of SAHA regulating cyclin D1 at level of protein degradation. Moreover, SAHA inhibited EGF-induced cyclin d1 mRNA level, whereas it did not show any inhibitory effect on cyclin D1 promoter-driven luciferase reporter activity under the same experimental conditions, suggesting that SAHA may decrease cyclin D1 mRNA stability. This notion was supported by the results that treatment of cells with SAHA decreased the half-life of cyclin D1 mRNA from 6.95 h to 2.57 h. Consistent with downregulation of cyclin D1 mRNA stability, SAHA treatment also attenuated HuR expression, which has been well-characterized as a positive regulator of cyclin D1 mRNA stability. Thus, our study identifies a novel mechanism responsible for SAHA inhibiting cell transformation via decreasing cyclin D1 mRNA stability and induction of G0/G1 growth arrest in Cl41 cells. -- Highlights: ► SAHA inhibits cell transformation in Cl41 cells. ► SAHA suppresses Cyclin D1 protein expression. ► SAHA decreases cyclin D1 mRNA stability.
Kaks soome-ugri keeleõppe projekti / Ivar Sinimets
Sinimets, Ivar
2010-01-01
Kahest ungari keele õpetamisele keskendunud projektist "survival.hu" ja "TeLeHu", mille eesmärgiks oli õppematerjalide valmistamine, õpetajate täiendamine ning ka hindamisaluste väljatöötamine ja ungari keele õpetajate infovõrgustiku loomine
Eesti keele evidentsiaalsussüsteem mõne teise keele taustal. Semantika / Petar Kehayov
Kehayov, Petar
2004-01-01
Eesti keele evidentsiaalsussüsteem võrrelduna balti, balkani, albaania ja türgi keeltega funktsionaalsest küljest: evidentsiaalsussüsteemide suhetest lähedalseisvate verbikategooriatega ning nende semantilis-pragmaatilistest funktsioonidest
Riik tasub uute kodanike eesti keele õpingute eest / Aleksei Günter
Günter, Aleksei, 1979-
2005-01-01
Et 2005. aasta novembris lõpeb kuus aastat kestnud EL-i keeleõppe toetuse projekt Interest, hakkab riik ise uuest aastast hüvitama eesti keele õppekulusid mittekodanikele, kes on edukalt sooritanud kodakondsuse saamiseks vajalikud eksamid. Lisa: Keeleõppe toetuse projekt Interest
LIIKUMISSÜNDMUSED EESTI KEELE ÕPPIJATE KIRJALIKES NARRATIIVIDES
Directory of Open Access Journals (Sweden)
Renate Pajusalu
2012-01-01
Full Text Available Artiklis käsitletakse vene emakeelega eesti keele õppijate (keeleoskustase B2 kirjalikes narratiivides esinenud liikumissündmusi. Materjaliks on M. Mayeri (1969 sõnadeta pildiraamatu “Frog, where are you?” järgi kirjutatud narratiivid. Põhimaterjal pärineb 21-lt vene emakeelega üliõpilaselt ning võrdlusmaterjal 21-lt eesti emakeelega üliõpilaselt. Õppijarühmalt on analoogiline tekstimaterjal kogutud ka nende emakeeles vene keeles. Liikumissündmuste analüüsimisel lähtutakse L. Talmy (1985, 2007 käsitlusest. Kitsamalt keskendutakse liikumissündmuste kirjeldamisel kasutatud verbidele ja verbisatelliitidele, liikumise lähte- ja sihtkoha väljendamisele ühe ja sama liikumissündmuse kirjeldamisel ning vaadeldakse suhtlusstrateegiate rakendamise võimalusi õppijarühma narratiivides. Analüüsitud keeleainese põhjal võib väita, et liikumisnarratiivi etappe eesti keele õppijad ei väldi. Samas kasutavad nad väga sageli üldise tähendusega liikumisverbe minema ja tulema, mis võimaldavad edasi anda piltidel kujutatud tegevuse dünaamikat, kuid milles ei sisaldu liikumisviis. Liikumise teed väljendavate verbisatelliitide (afiksaaladverbide kasutamine ei ole vene emakeelega õppijatele raske. Kuna eesti keele afiksaaladverbid ja vene keele verbiprefiksid on funktsionaalselt sarnased, on tõenäoline, et õppijad on toetunud vene keele verbiprefiksite analoogiale. Vene üliõpilaste narratiive iseloomustab ka liikumise lähte- ja sihtkoha sage liitmine ühe ja sama liikumissündmuse kirjeldusse ning staatilise olema-verbi kasutamine liikumise kirjeldamisel. Viimane on käsitatav õppijatele omase ümberütlemisstrateegiana ning eesti võrdlusrühma narratiivides ei esine.
Li, Xinyu; Zhou, Qinbo; Hanus, Jakub; Anderson, Chastain; Zhang, Hongmei; Dellinger, Michael; Brekken, Rolf; Wang, Shusheng
2013-01-01
Neovascularization (NV) in the cornea is a major cause of vision impairment and corneal blindness. Hemangiogenesis and lymphangiogenesis induced by inflammation underlie the pathogenesis of corneal NV. The current mainstay treatment, corticosteroid, treats the inflammation associated with corneal NV, but is not satisfactory due to such side effects as cataract and the increase in intraocular pressure. It is imperative to develop a novel therapy that specifically targets the hemangiogenesis, lymphangiogenesis and inflammation pathways underlying corneal NV. Histone deacetylase inhibitors (HDACi) have been in clinical trials for cancer and other diseases. In particular, HDACi suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza) has been approved by the FDA for the treatment of cutaneous T-cell lymphoma. The functional mechanism of SAHA in cancer and especially in corneal NV remains unclear. Here, we show that topical application of SAHA inhibits neovascularization in an alkali-burn corneal injury model. Mechanistically, SAHA inhibits corneal NV by repressing hemangiogenesis, inflammation pathways and previously overlooked lymphangiogenesis. Topical SAHA is well tolerated on the ocular surface. In addition, the potency of SAHA in corneal NV appears to be comparable to the current steroid therapy. SAHA may possess promising therapeutic potential in alkali-burn corneal injury and other inflammatory neovascularization disorders. PMID:23186311
Energy Technology Data Exchange (ETDEWEB)
Southworth, Brian
1989-12-15
The start of construction of the 87-kilometre US Superconducting Supercollider (SSC) was celebrated in Dallas at the beginning of October with a Texas-style meeting on SSC physics and experiments. Chris Quigg described it as 'laying the keel of a new vessel of discovery'. The vessel is scheduled to make its maiden voyage with 20 TeV (20,000 GeV) proton beams in 1998.
Komendandi Kahni-raamat prantsuse keeles
2006-01-01
Väliseesti inseneri August Komendandi raamat koostööst arhitekti Louis Kahniga ilmus prantsuse keeles pealkirjaga "Dixhuit annees avec Louis I. Kahn". Tiitellehel on avaldatud tänu Mart Kalmule teabe andmise eest
Keeleinimesed muretsevad inglise keele sissetungi pärast / Kaarel Kressa
Kressa, Kaarel, 1983-
2007-01-01
Kumu auditooriumis toimunud keelefoorumil arutati eesti keele tulevikuväljavaateid. Tallinna Ülikooli õppejõud Heli Mattisen osutas faktile, et toimumas on inglise keele hiiliv sulandumine kõrgharidusse. Mati Hindile tegi muret eestikeelse muusika vähesus riigiraadios
Virtuaalne keeleõpe / Ege Meister
Meister, Ege
2004-01-01
Leonardi da Vinci programmi raames toimuvast rahvusvahelisest koostööst tehniliste erialade õpilastele inglise keele õpetamiseks. Projektist LENTEC, mille raames eri riikide õpilased õppisid virtuaalselt inglise keelt ning lahendasid ühiselt tehnikateemalisi ülesandeid
Directory of Open Access Journals (Sweden)
Xing Wu
2014-08-01
Full Text Available Background/Aim: P21, a multifunctional cell cycle-regulatory molecule, regulates apoptotic cell death. In this study we examined the effect of altered p21 expression on the sensitivity of acute myeloid leukemia cells in response to HDAC inhibitor SAHA treatment and investigated the underlying mechanism. Methods: Stably transfected HL60 cell lines were established in RPMI-1640 with supplementation of G-418. Cell viability was measured by MTT assay. Western blot was applied to assess the protein expression levels of target genes. Cell apoptosis was monitored by AnnexinV-PE/7AAD assay. Results: We showed HL60 cells that that didn't up-regulate p21 expression were more sensitive to SAHA-mediated apoptosis than NB4 and U937 cells that had increased p21 level. Enforced expression of p21 in HL60 cells reduced sensitivity to SAHA and blocked TRAIL-mediated apoptosis. Conversely, p21 silencing in NB4 cells enhanced SAHA-mediated apoptosis and lethality. Finally, we found that combined treatment with SAHA and rapamycin down-regulated p21 and enhanced apoptosis in AML cells. Conclusion: We conclude that up-regulated p21 expression mediates resistance to SAHA via inhibition of TRAIL apoptotic pathway. P21 may serve as a candidate biomarker to predict responsiveness or resistance to SAHA-based therapy in AML patients. In addition, rapamycin may be an effective agent to override p21-mediated resistance to SAHA in AML patients.
International Nuclear Information System (INIS)
Sato, M.
1991-01-01
The Saha equation for a plasma in thermodynamic equilibrium (TE) is approximately solved to give the temperature as an explicit function of population densities. It is shown that the derived expressions for the Saha temperature are valid approximations to the exact solution. An application of the approximate temperature to the calculation of TE plasma parameters is also described. (orig.)
The Influence of Keel Bone Damage on Welfare of Laying Hens
Directory of Open Access Journals (Sweden)
Anja B. Riber
2018-02-01
Full Text Available This article reviews current knowledge about welfare implications of keel bone damage in laying hens. As an initial part, we shortly describe the different conditions and present major risk factors as well as findings on the prevalence of the conditions. Keel bone damage is found in all types of commercial production, however with varying prevalence across systems, countries, and age of the hens. In general, the understanding of animal welfare is influenced by value-based ideas about what is important or desirable for animals to have a good life. This review covers different types of welfare indicators, including measures of affective states, basic health, and functioning as well as natural living of the birds, thereby including the typical public welfare concerns. Laying hens with keel bone fractures show marked behavioral differences in highly motivated behavior, such as perching, nest use, and locomotion, indicating reduced mobility and potentially negative affective states. It remains unclear whether keel bone fractures affect hen mortality, but there seem to be relations between the fractures and other clinical indicators of reduced welfare. Evidence of several types showing pain involvement in fractured keel bones has been published, strongly suggesting that fractures are a source of pain, at least for weeks after the occurrence. In addition, negative effects of fractures have been found in egg production. Irrespective of the underlying welfare concern, available scientific evidence showed that keel bone fractures reduce the welfare of layers in modern production systems. Due to the limited research into the welfare implications of keel bone deviation, evidence of the consequences of this condition is not as comprehensive and clear. However, indications have been found that keel bone deviations have a negative impact on the welfare of laying hens. In order to reduce the occurrence of the conditions as well as to examine how the affected
Johnson, Jennifer; Pahuja, Anil; Graham, Melanie; Hering, Bernhard; Hancock, Wayne W.; Pratima, Bansal-Pakala
2008-01-01
SAHA, a histone deacetylase inhibitor (HDACi), is clinically approved for treatment of cutaneous T-cell lymphoma. Although the exact underlying mechanisms are unknown, HDACi arrest the cell cycle in rapidly proliferating tumor cells and promote their apoptosis. HDACi were also recently shown to enhance the production and suppressive functions of Foxp3+ regulatory T (Treg) cells in rodents, leading us to begin to investigate the actions of HDACi on rhesus monkey T cells for the sake of potential preclinical applications. In this study, we show that SAHA inhibits polyclonal activation and proliferation of rhesus T cells and that the anti-proliferative effects are due to inhibition of T effector (Teff) cells and enhancement of Treg cells. Cryopreserved rhesus macaque splenocytes were CFSE labeled, stimulated with anti-CD3/anti-CD28 and cultured for 5 days in the presence of varying concentrations of SAHA. Samples were then co-stained to evaluate CD4 and CD8 expression. 10 and 5μM concentrations of SAHA were toxic to splenocytes. Proliferation was inhibited by 57% in CD4 cells and 47% in CD8 cells when unseparated splenocytes were cultured with 3 μM SAHA. Effector cells alone showed a decreased inhibition to proliferation when cultured with 3 μM and 1 μM SAHA when compared to Teff plus Treg cells. Our data suggest that SAHA can be used as part of an immunosuppressive protocol to enhance graft survival by limiting Teff cell proliferation as well as increasing Treg cells, thereby promoting tolerance. PMID:18374101
SCADA Sistemi ile Bir İşletmenin Dış Saha Otomasyonu
Kılıç, Murat; Özdemir, Şule
2010-01-01
Bu çalışmada, PLC (Programmable Logic Controller: Programlanabilir Mantık Denetleyici) ve SCADA (Supervising Control and Data Acquisition: Veri Tabanlı Kontrol ve Gözetleme) sistemleriyle bir MDF (Medium Density Fiberboard) presi dış saha besleme hattının otomasyonu gerçekleştirilmiştir. Tüm sistem SCADA sayesinde bilgisayar ekranından izlenebilmekte ve kontrol edilebilmektedir. MDF presi dış saha besleme hattı tam otomasyon ile çalışmaktadır. Otomasyon sisteminde PLC yazılımı olarak Siemens ...
Meghnad Saha his life in science and politics
Naik, Pramod V
2017-01-01
This biography is a short yet comprehensive overview of the life of Meghnad Saha, the mastermind behind the frequently used Saha equations and a strong contributor to the foundation of science in India. The author explores the lesser known details behind the man who played a major role in building scientific institutions in India, developed the breakthrough theory of thermal ionization, and whose fervor about India’s rapid progress in science and technology, along with concern for uplifting his countrymen and optimizing resources, led him to eventually enter politics and identify the mismanagement of many programs of national importance to Parliament. This book is free of most academic technicalities, so that the reader with general scientific knowledge can read and understand it easily. One interested only in Saha’s contribution to physics can pick up just that part and read it. Conversely, the average reader may skip the technical chapters, and read the book without loss of continuity or generality to s...
International Nuclear Information System (INIS)
Folkvord, Sigurd; Ree, Anne Hansen; Furre, Torbjorn; Halvorsen, Thomas; Flatmark, Kjersti
2009-01-01
Purpose: Histone deacetylase inhibitors are being evaluated as antitumor agents in ongoing clinical trials, and promising preclinical results, combined with favorable toxicity profiles, have rendered the drugs as interesting candidates for combination with other treatment modalities, such as radiotherapy. The aim of the present study was to evaluate the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) and the possible requirement of histone hyperacetylation at radiation exposure. Methods and materials: Radiosensitization by SAHA was assessed in a colorectal carcinoma cell line and in two colorectal xenograft models by analysis of clonogenic survival and tumor growth delay, respectively. Histone acetylation status at radiation exposure was evaluated by Western blot. Results: In vitro, radiosensitization was demonstrated when cells were preincubated with SAHA, and, in the xenografts, tumor growth was delayed when the mice were treated with fractionated radiation combined with daily SAHA injections compared with radiation alone. Surprisingly, the SAHA-dependent growth delay was still present when radiation was delivered at restored baseline acetylation levels compared with maximal histone hyperacetylation. Conclusion: SAHA was an effective radiosensitizer in experimental colorectal carcinoma models, suggesting that histone deacetylase inhibition might constitute a valuable supplement to current multimodal treatment strategies in rectal cancer. The presence of histone hyperacetylation at radiation was not required to obtain an increased radiation response, questioning the validity of using histone hyperacetylation as a molecular marker for radiosensitivity.
KEEL 3.0: An Open Source Software for Multi-Stage Analysis in Data Mining
Directory of Open Access Journals (Sweden)
Isaac Triguero
2017-01-01
Full Text Available This paper introduces the 3rd major release of the KEEL Software. KEEL is an open source Java framework (GPLv3 license that provides a number of modules to perform a wide variety of data mining tasks. It includes tools to perform data management, design of multiple kind of experiments, statistical analyses, etc. This framework also contains KEEL-dataset, a data repository for multiple learning tasks featuring data partitions and algorithmsr results over these problems. In this work, we describe the most recent components added to KEEL 3.0, including new modules for semi-supervised learning, multi-instance learning, imbalanced classification and subgroup discovery. In addition, a new interface in R has been incorporated to execute algorithms included in KEEL. These new features greatly improve the versatility of KEEL to deal with more modern data mining problems.
Keel-bone damage and foot injuries in commercial laying hens in Denmark
DEFF Research Database (Denmark)
Riber, Anja Brinch; Hinrichsen, Lena Karina
2016-01-01
. There was no difference between barn and organic production systems in the risk of having keel-bone fractures and foot injuries, except that barn hens were more likely to have foot-pad lesions than organic hens(32 weeks: 16.1 vs 3.1%). Hens in multi-tiered systems were more likely to have keel-bone fractures compared...... to hens in single-tiered systems (62 weeks: 11.6 vs 4.9 %). Of the four hybrids, Lohmann Brown Lite had a higher risk of keel-bone fractures, whereas bumble feet were found more frequently in Lohmann LSL. Keel-bone damage and foot injuries are less common in Danish non-cage systems compared to most...
Koreinik, Kadri
2013-01-01
Artikli peaeesmärgina analüüsitakse keele kestlikkuse ja kao diskursiivset konstrueerimist Saksamaa ja Soome eestlaste ning setu ja võru keele kasutajate näitel. Tutvustatakse ka rahvusvahelist valdkondadevahelist ELDIA (European language diversity for all) projekti
Keele kestlikkuse ja kao konstrueerimine poolavalikes diskursustes
Directory of Open Access Journals (Sweden)
Kadri Koreinik
2013-04-01
Full Text Available Artikli peaeesmärk on analüüsida keele kestlikkuse ja kao diskursiivset konstrueerimist Saksamaa ja Soome eestlaste ning setu ja võru keele kasutajate poolstruktureeritud intervjuude näitel. Intervjuuandmestik pärineb koostööprojektist European Language Diversity for All (ELDIA, mille keskmes on väikese kõnelejaskonnaga soome-ugri keeled tänapäeva mitmekeelsetes ühiskondades. Saksamaal ja Soomes elavad eestlased esindavad allohtoonseid keelerühmi; setu- ja võrukeelsed moodustavad autohtoonsed Eesti keelekogukonnad, mille piiritlemine pole probleemitu. Kõigi nimetatud kogukondade puhul on tegu mitmekeelsete eestlastega, kes on suuremal või vähemal määral säilitanud oma vähemuskeele enamuskeelses, vastavalt saksa-, soome- ja eestikeelses keeleruumis. Diskursusanalüüsi kõrval vaadeldakse põgusalt, kuidas hindavad oma keeleoskust erinevas vanuses inimesed. Kogu keelekestlikkuse ja -kao diskursus on vaadeldav legitimatsioonidiskursusena, kus osalised argumenteerivad vähemuskeelte funktsioonide ja tuleviku üle. Ühe põhitulemusena võib esile tuua, et kõik vaadeldud keelekogukonnad püsivad keelelise või kultuurilise rikastamise diskursiivses raamistikus. DOI: http://dx.doi.org/10.5128/ERYa9.09
Eesti keele ja kultuuri suvekursus : BALSSI 2006-BALSSI 2007 / Piibi-Kai Kivik
Kivik, Piibi-Kai
2007-01-01
eesti keele õpinguist Indiana Ülikoolis Bloomingtonis Balti keele ja kultuuri suvekoolis (BALSSI=Baltic Studies Summer Institute) 2006. a. suvel ja 2007. a. korraldatavast suvekoolist California Ülikoolis, Los Angeleses
Nasr, M A F; Murrell, J; Nicol, C J
2013-01-01
The impact of keel bone fractures on egg production, egg weight and feed and water consumption in individual laying hens. A total of 165 Lohmann brown laying hens were obtained from a commercial farm that consisted of 105 with keel fractures and 60 without keel fractures. 2. After a 4-d period of acclimatisation, hens were individually housed and provided with ad libitum food and water for a 24-h period. The number of eggs laid, egg weight, feed and water consumption during this period were recorded. Keel bone strength was also assessed. 3. Hens free from keel fractures laid more eggs (91.7% vs. 84.9%) of significantly heavier weight (61.9 g vs. 60.2 g), ate less feed (139 g vs. 151 g) and drank less water (212 ml vs. 237 ml) than hens with fractures. 4. There was a significant positive association between keel fracture severity and water consumption, and a significant negative association between keel fracture severity and egg weight and keel bone strength. 5. This small-scale study on individual birds shows that keel bone fractures may have an impact on the economics of egg production.
Korea keele õpetamisest / Angelina Tšaikovskaja
Tšaikovskaja, Angelina
1999-01-01
Tallinna Pedagoogikaülikooli külastas 7. dets. 1999 Korea Vabariigi suursaadik Helsingis Dong-chil Yang, kes tundis huvi idamaade keelte õpetamise vastu TPÜ-s ja lubas toetada korea keele õpetamist ülikoolis
2016-10-06
cognitive technology for application in automotive , industrial automation, medical, military, governmental, enterprise software and electronic gaming...Executing, and Auditing) This paper focuses on the decision-making component (#2) with the use of Knowledge Enhanced Electronic logic (KEEL) Technology... markets . The company is headquartered in Brookfield, Wisconsin. KEEL® Technology is covered by granted (6,833,842, 7,039,623, 7,009,610, 7,159,208
Inglise keele õppekomplekt lastele / Katrin Tariq
Tariq, Katrin
2001-01-01
4-10-aastaste laste inglise keele õppekomplekti kuuluvad : piltsõnastik, töövihik, sõnakaardid, plakatid, lauamäng, mänguasjad. Rets. : Müürsepp, Mare. My home, family and friends. - Tallinn : TEA Kirjastus, 2001
Opacity calculations and Saha's equation for high Z elements
International Nuclear Information System (INIS)
Godwal, B.K.; Sikka, S.K.
1977-01-01
Opacity calculations are needed for energy transport by radiation for high Z element plasmas as these have been suggested as temper materials in laser, electron beam and heavy ion fusion schemes. The pressure ionised modified form of Saha's ionisation equation has been used to obtain the free electron density, populations of various ionic species and the populations of various energy states for a given ion. Results are presented for two typical elements; tungsten and uranium. The ionisation potential have been evaluated using the Bohr's formula with suitable effective screened charges for ions. The results show that for uranium, even at a temperature of 10 kev, the K shell is intact. The reliability of the Saha's equation solution has been checked by comparing the equation of state (total pressure vs total energy curve) with that given by the Thomas-Fermi-Dirac equation of state. The agreement between the two is good from temperature upwards of 0.2 kev. (author)
Õlu, Autobahn, Hitler ja saksa keel Eestis / Heiko F. Martens, Maris Saagpakk
Martens, Heiko F.
2013-01-01
Saksa keele õppijate osakaalu langusest Eestis. Aastail 2011-2012 korraldati kolmes Balti riigis uuring, selgitamaks asjaolusid, mis mängivad rolli saksa keele õppimise poolt või vastu otsustamisel
Mitmuse osastav eesti keele käändesüsteemis / Heiki-Jaan Kaalep
Kaalep, Heiki-Jaan, 1962-
2010-01-01
Jätkatakse eesti keele sõnamuutmissüsteemi vaatlemisel suunda, millega alustas sama autor "Keeles ja Kirjanduses" 2009, nr. 6: "Kuidas kirjeldada ainsuse lühikest sisseütlevat kasutamisandmetega kooskõlas?"
Directory of Open Access Journals (Sweden)
Michal Mielcarek
Full Text Available Huntington's disease (HD is a progressive neurological disorder for which there are no disease-modifying treatments. Transcriptional dysregulation is a major molecular feature of HD, which significantly contributes to disease progression. Therefore, the development of histone deacetylase (HDAC inhibitors as therapeutics for HD has been energetically pursued. Suberoylanilide hydroxamic acid (SAHA - a class I HDAC as well an HDAC6 inhibitor, improved motor impairment in the R6/2 mouse model of HD. Recently it has been found that SAHA can also promote the degradation of HDAC4 and possibly other class IIa HDACs at the protein level in various cancer cell lines. To elucidate whether SAHA is a potent modifier of HDAC protein levels in vivo, we performed two independent mouse trials. Both WT and R6/2 mice were chronically treated with SAHA and vehicle. We found that prolonged SAHA treatment causes the degradation of HDAC4 in cortex and brain stem, but not hippocampus, without affecting its transcript levels in vivo. Similarly, SAHA also decreased HDAC2 levels without modifying the expression of its mRNA. Consistent with our previous data, SAHA treatment diminishes Hdac7 transcript levels in both wild type and R6/2 brains and unexpectedly was found to decrease Hdac11 in R6/2 but not wild type. We investigated the effects of SAHA administration on well-characterised molecular readouts of disease progression. We found that SAHA reduces SDS-insoluble aggregate load in the cortex and brain stem but not in the hippocampus of the R6/2 brains, and that this was accompanied by restoration of Bdnf cortical transcript levels.
International Nuclear Information System (INIS)
Werner, H.W.; Morgan, A.E.
1978-01-01
Some thoughts are presented on the physical processes described by the Saha-Eggert equation and some estimates are made regarding equilibration in a spike generated by ion bombardment. The influence of different parameters on the temperature determined from the Saha-Eggert equation is discussed. Section headings are: ionization in a spike; equilibration in a spike; factors influencing the ionization temperature (primary ion energy, secondary ion energies, presence of oxygen (an example shows the ionization temperature for uranium as a function of secondary ion energies and bombarding conditions)). (U.K.)
Eesti keele kui teise keele kirjutamisprotsessi sujuvuse võrdlus keeleoskustasemeti
Directory of Open Access Journals (Sweden)
Olga Pastuhhova
2017-05-01
Full Text Available "Comparison of fluency across proficiency levels in the writing process of native Russian-speaking learners of Estonian as a second language" The aim of the current article is to describe fluency across proficiency levels in the writing process of native Russian-speaking learners of Estonian as a second language. The data of the study consist of texts written by 34 participants, all of whom were students at Tallinn University. The data were collected with the computer keystroke logging program ScriptLog. The written argumentative and narrative texts were rated by two experts according to the Common European Framework of Reference for Languages (CEFR. The data were representative of four CEFR language proficiency levels: A2 (4 texts, B1 (13, B2 (13, and C1 (4. Fluency was analysed and described according to process, product, revision, pausing behaviour, and keyboard skills. Furthermore, the fluency of the writing process was measured on the basis of online and offline measures. The results of the study were compared across the proficiency levels. The fluency of the writing process increases with growth in proficiency, the greatest development being observed between levels B2 and C1. Artikli eesmärk on uurida venekeelsete eesti keele õppijate kirjutamisprotsessi sujuvust ja selle seost “Euroopa keeleõppe raamdokumendi” A2-, B1-, B2- ja C1- keeleoskustasemega. Uurimuses osales 34 venekeelset üliõpilast, kellel paluti kirjutada loovkirjutis haridusteemal. Materjal on kogutud klaviatuuri klahvivajutuste salvestuse meetodil põhineva ScriptLog-programmiga. Sujuvust analüüsitakse kirjutamisprotsessi, lõpliku teksti, paranduste, pauside ning klaviatuuri kasutamisoskuse seisukohast. Lisaks on sujuvus arvutatud vastavalt protsessi ja produkti indikaatoritele. Uurimuse tulemusi võrreldakse keeleoskustasemeti. Tulemused osutavad, et teksti produtseerimine muutub keeleoskuse arenedes sujuvamaks, suurim areng on märgatav B2- ja C1-taseme vahel.
Directory of Open Access Journals (Sweden)
Campbell P
2016-10-01
Full Text Available Paul Campbell,1 Jonathan C Hill,1 Joanne Protheroe,1 Ebenezer K Afolabi,1 Martyn Lewis,1 Ruth Beardmore,1 Elaine M Hay,1 Christian D Mallen,1 Bernadette Bartlam,1 Benjamin Saunders,1 Danielle A van der Windt,1 Sue Jowett,2 Nadine E Foster,1 Kate M Dunn1 1Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, 2Health Economics Unit, University of Birmingham, Birmingham, UK Abstract: Musculoskeletal conditions represent a considerable burden worldwide, and are predominantly managed in primary care. Evidence suggests that many musculoskeletal conditions share similar prognostic factors. Systematically assessing patient’s prognosis and matching treatments based on prognostic subgroups (stratified care has been shown to be both clinically effective and cost-effective. This study (Keele Aches and Pains Study aims to refine and examine the validity of a brief questionnaire (Keele STarT MSK tool designed to enable risk stratification of primary care patients with the five most common musculoskeletal pain presentations. We also describe the subgroups of patients, and explore the acceptability and feasibility of using the tool and how the tool is best implemented in clinical practice. The study design is mixed methods: a prospective, quantitative observational cohort study with a linked qualitative focus group and interview study. Patients who have consulted their GP or health care practitioner about a relevant musculoskeletal condition will be recruited from general practice. Participating patients will complete a baseline questionnaire (shortly after consultation, plus questionnaires 2 and 6 months later. A subsample of patients, along with participating GPs and health care practitioners, will be invited to take part in qualitative focus groups and interviews. The Keele STarT MSK tool will be refined based on face, discriminant, construct, and predictive validity at baseline and 2
Negmeldin, Ahmed Thabet
HDAC proteins have emerged as interesting targets for anti-cancer drugs due to their involvement in cancers, as well as several other diseases. Several HDAC inhibitors have been approved by the FDA as anti-cancer drugs, including SAHA (suberoylanilide hydroxamic acid, Vorinostat). Unfortunately, SAHA inhibits most HDAC isoforms, which limit its use as a pharmacological tool and may lead to side effects in the clinic. In this work we were interested in developing isoform selective HDAC inhibitors, which may decrease or eliminate the side effects associated with non-selective inhibitors treatment. In addition, isoform selective HDAC inhibitors can be used as biological tools to help understand the HDAC-related cancer biology. Our strategy was based on synthesis and screening of several derivatives of the non-selective FDA approved drug SAHA substituted at different positions of the linker region. Several SAHA analogs modified at the C4 and C5 positions of the linker were synthesized. The new C4- and C5-modified SAHA libraries, along with the previously synthesized C2-modified SAHA analogs were screened in vitro and in cellulo for HDAC isoform selectivity. Interestingly, several analogs exhibited dual HDAC6/HDAC8 selectivity. Enantioselective syntheses of the pure enantiomers of some of the interesting analogs were performed and the enantiomers were screened in vitro. Among the most interesting analogs, ( R)-C4-benzyl SAHA displayed 520- to 1300-fold selectivity for HDAC6 and HDAC8 over HDAC1, 2, and 3, with IC50 values of 48 and 27 nM with HDAC6 and 8, respectively. Docking studies were performed to provide structural rationale for the observed selectivity of the new analogs. In addition, rational design, synthesis, and screening of several other biaryl indolyl benzamide HDAC inhibitors is discussed, and some showed modest HDAC1 selectivity. The new biaryl indolyl benzamides can be useful to further develop HDAC1 selective inhibitors. The dual HDAC6/8 selective
Quantum degeneracy corrections to plasma line emission and to Saha equation
International Nuclear Information System (INIS)
Molinari, V.G.; Mostacci, D.; Rocchi, F.; Sumini, M.
2003-01-01
The effect of quantum degeneracy on the electron collisional excitation is investigated, and its effects on line emission evaluated for applications to spectroscopy of dense, cold plasmas. A correction to Saha equation for weakly-degenerate plasmas is also presented
Vene keele 1. suvekool / Dimitri Mironov
Mironov, Dimitri
2001-01-01
2001.a. suvel korraldas TPÜ slaavi filoloogia osakond koostöös välissuhete osakonnaga vene keele suvekooli, mis oli mõeldud välisüliõpilastele. Kaks ja pool nädalat kestnud kursuste jooksul õppisid tudengid Soomest, Inglismaalt ja Hispaaniast intensiivselt vene keelt ning osalesid vene kultuuri tutvustavas programmis
Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics
Indian Academy of Sciences (India)
1990 to date a variety of medium energy heavy ions were made available from the BARC-TIFR Pel- letron and the Nuclear Science Centre Pelletron. The state of the art gamma detector arrays in these centres enabled the Saha Institute groups to undertake more sophisticated experiments. Front line nuclear spectroscopy ...
The Influence of Keel Bone Damage on Welfare of Laying Hens
DEFF Research Database (Denmark)
Riber, Anja Brinch; Casey-Trott, Teresa M.; Herskin, Mette S.
2018-01-01
This article reviews current knowledge about welfare implications of keel bone damage in laying hens. As an initial part, we shortly describe the different conditions and present major risk factors as well as findings on the prevalence of the conditions. Keel bone damage is found in all types...... of commercial production, however with varying prevalence across systems, countries, and age of the hens. In general, the understanding of animal welfare is influenced by value-based ideas about what is important or desirable for animals to have a good life. This review covers different types of welfare...... indicators, including measures of affective states, basic health, and functioning as well as natural living of the birds, thereby including the typical public welfare concerns. Laying hens with keel bone fractures show marked behavioral differences in highly motivated behavior, such as perching, nest use...
Evolution of nuclear spectroscopy at Saha Institute of Nuclear Physics
Indian Academy of Sciences (India)
Currently Saha Institute is building a multi-element gamma heavy ion neutron array detector (MEGHNAD), which will have six high efficiency clover Ge detector together with charged particle ball and other accessories. The system is expected to be usable in 2002 and will be used in experiments using high energy heavy ...
Nuclear structure studies at Saha Institute of Nuclear Physics using ...
Indian Academy of Sciences (India)
In-beam gamma-ray spectroscopy, carried out at the Saha Institute of Nuclear Physics in the recent past, using heavy-ion projectiles from the pelletron accelerator centres in the country and multi-detector arrays have yielded significant data on the structure of a large number of nuclei spanning different mass regions.
Angela Marcantonio ungari keeles / Ago Künnap
Künnap, Ago, 1941-
2007-01-01
Arvustus: A történeti nyelvészet és a magyar nyelv eredete. Angela Marcantonio v{u00E1logatott tanulm{u00E1nyai. Budapest : HUN-idea Kiado, 2006. [Ajalooline keeleteadus ja ungari keele päritolu. Angela Marcantonio valitud uurimused
Dennison, Sophie E; Paul-Murphy, Joanne R; Yandell, Brian S; Adams, William M
2010-01-01
Healthy, adult Hispaniolan Amazon parrots (Amazona ventralis) were imaged on three occasions to determine the effects of anesthesia, patient rotation, feeding, and short/long-term temporal factors on the proventriculus:keel ratio. Increasing rotation up to 15 degrees from right lateral resulted in increased inability to measure the proventriculus in up to 44% of birds, meaning that the proventriculus:keel ratio could not be calculated from those radiographs. There was a significant difference between the proventriculus:keel ratio for individual parrots when quantified 3 weeks apart. Despite this difference, all ratios remained within normal limits. No significant effect was identified due to anesthesia, feeding, fasting, or repeated imaging through an 8-h period. Interobserver agreement for measurability and correlation for the proventriculus:keel ratio values was high. It is recommended that the proventriculus:keel ratio be calculated from anesthetized parrots to attain images in true lateral recumbency. Ratio fluctuations within the normal range between radiographs obtained on different dates may be observed in normal parrots.
Kibar, Triin
2009-01-01
Artiklis analüüsitakse erinevaid lähenemisi keeleõppemotivatsioonile ning antakse ülevaade Tallinna Ülikooli venekeelsete üliõpilaste eesti keele õppe motivatsioonilisest orientatsioonist. Artikkel põhineb autori magistritöö raames tehtud uurimusel, milles osales 80 TLÜ venekeelset tudengit, kes õppisid 2008. a. kevadsemestril erialast eesti keelt
International Nuclear Information System (INIS)
Numano, M.
1976-01-01
The growth rates for the ionization instability obtained using the Saha and temperature relaxation approximations are compared with those obtained from an exact treatment, and the requirements for validity of these two approximations are obtained analytically. For the range of plasma parameters pertinent to MHD power generation it is found that the Saha approximation is valid for relatively high electron temperature, which it becomes inapplicable as the electron temperature is decreased. On the other hand, the temperature relaxation approximation is accurate over a wide range of electron temperature. It is found also that the marginal condition for the ionization instability is correctly obtained from both approximations. (author)
Rahvusvaheline inglise keele eksam Narvas / Alisa Lanno
Lanno, Alisa
2011-01-01
14. detsembril tutvustasid Tallinna Ülikooli keelekeskuse juhataja Tuuli Oder ja Tartu Ülikooli Narva kolledži direktor Katri Raik koostööprojekti, mille käigus avatakse kolledži juures rahvusvahelise inglise keele eksami info- ja testimiskeskus. Esialgu on Narvas võimalik sooritada IELTS (International English Language Testing System) eksamit
Eesti keele oskust saab ise mõõta
2009-01-01
Eesti keele veebipõhistest testidest, mis lihtsustab nii kursuse- kui eksamivalikut. Keeleoskust testitakse viie Euroopa Liidus kasutatava keeletaseme ulatuses: tasemest A1 tasemeni C1. Veebikeskkond valmis integratsiooni sihtasutuse, riikliku eksami- ja kvalifikatsioonikeskuse, Juku Lab OÜ ning Tallinna Ülikooli koostöös
"Wow!" - inglise keel täiesti uutmoodi / Helen Talalaev
Talalaev, Helen
2009-01-01
2008. aastal TEA kirjastuselt põhikoolile ja gümnaasiumile ilmuma hakanud uutest inglise keele õppekomplektide sarjadest "Wow!", "Key English" ja "In Touch", mis valmivad Eesti, Briti ja Soome autorite ühistööna
Directory of Open Access Journals (Sweden)
Leopold F Fröhlich
Full Text Available The lack of knowledge about molecular pathology of uterine sarcomas with a representation of 3-7% of all malignant uterine tumors prevents the establishment of effective therapy protocols. Here, we explored advanced therapeutic options to the previously discovered antitumorigenic effects of the histone deacetylase (HDAC inhibitor suberoylanilide hydroxamic acid (SAHA by combined treatment with the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo-2L. In addition, we investigated the uterine sarcoma cell lines, MES-SA and ESS-1, regarding the underlying molecular mechanisms of SAHA and TRAIL-induced apoptosis and their resistance towards TRAIL. Compared to single SAHA or TRAIL treatment, the combination of SAHA with TRAIL led to complete cell death of both tumor cell lines after 24 to 48 hours. In contrast to single SAHA treatment, apoptosis occured faster and was more pronounced in ESS-1 cells than in MES-SA cells. Induction of SAHA- and TRAIL-induced apoptosis was accompanied by upregulation of the intrinsic apoptotic pathway via reduction of mitochondrial membrane potential, caspase-3, -6, and -7 activation, and PARP cleavage, but was also found to be partially caspase-independent. Apoptosis resistance was caused by reduced expression of caspase-8 and DR 4/TRAIL-R1 in ESS-1 and MES-SA cells, respectively, due to epigenetic silencing by DNA hypermethylation of gene promoter sequences. Treatment with the demethylating agent 5-Aza-2'-deoxycytidine or gene transfer therefore restored gene expression and increased the sensitivity of both cell lines against TRAIL-induced apoptosis. Our data provide evidence that deregulation of epigenetic silencing by histone acetylation and DNA hypermethylation might play a fundamental role in the origin of uterine sarcomas. Therefore, tumor growth might be efficiently overcome by a cytotoxic combinatorial treatment of HDAC inhibitors with TRAIL.
Thermodynamic inconsistency of the modified Saha equation at high pressures
International Nuclear Information System (INIS)
Sweeney, M.A.
1978-01-01
The inclusion of a pressure ionization term in the Saha equation violates the thermodynamic Maxwell identities if corresponding changes are not made to the expressions for entropy and pressure. It is demonstrated that the usual application of the Rouse and Stewart-Pyatt modesl suffers from this limitation. Negative values of the adiabatic gradient in the degenerate dwarf models of Boehm and Straka are explained in terms of this thermodynamic inconsistency
Thermodynamic derivation of Saha's equation for a multi-temperature plasma
International Nuclear Information System (INIS)
Morro, Angelo; Romeo, Maurizio
1988-01-01
The ionization equilibrium between the constituents of a multi-temperature plasma is investigated within the thermodynamics of fluid mixtures. As a result, a law of mass action is derived that, in the approximation of ideal gases for the constituents, leads to a direct generalization of Saha's equation. The main properties of this generalization are discussed, and contrasted with those of other equations which have appeared in the literature. (author)
Anesthesia management for a case of laryngeal keel placement
Directory of Open Access Journals (Sweden)
Kundan Gosavi
2017-01-01
Full Text Available Congenital laryngeal web is a rare anomaly with incidence of 1 in 10,000 births. Its clinical presentation may range from an asymptomatic patient or mild hoarseness of voice to severe respiratory stridor. The primary goals of surgical intervention for congenital laryngeal web are to establish a patent airway and to achieve a good voice quality. As recurrence rate after plain excision of laryngeal web is very high, its removal may be coupled by placement of a silastic keel in between vocal cords. Endolaryngeal placement of a keel is definitely less invasive than laryngofissure, but little is known about its anesthesia management. Frequent ventilatory adjustment and endotracheal tube (ETT manipulations are needed along with vigilant monitoring. Risk of perforation or accidental dislodgment of the ETT and laryngeal edema are other concerns in management. We report a case.
Directory of Open Access Journals (Sweden)
Renate Pajusalu
2014-04-01
Full Text Available Artikkel käsitleb palvete ja küsimuste vormistamise stereotüüpe eesti, vene ja soome keeles. Materjal on kogutud küsitluste abil, milles vastajad pidid kirjutama, mida nad kirjeldatud situatsioonis ütleksid või kirjutaksid (nn diskursuse täiendamise ülesanne. Iga vaadeldava keele kohta loodi andmebaas, milles on 200 palvet. Nende alusel vaadeldakse kümmet esitatud situatsiooni võrdlevalt kolmes keeles, tuues välja nii sarnasused kui erinevused. Kokkuvõttes tehakse üldistused palvete kodeerimisel esinenud sagedamate grammatiliste vahendite (lausetüüp, verbi morfoloogiline vorm, eituse olemasolu, pöördumine sina- või teie-vormiga jm esinemise kohta eesti, soome ja vene keeles.
Directory of Open Access Journals (Sweden)
Sabine G. Gebhardt-Henrich
2017-08-01
Full Text Available Keel bone damage is a wide-spread welfare problem in laying hens. It is unclear so far whether bone quality relates to keel bone damage. The goal of the present study was to detect possible associations between keel bone damage and bone properties of intact and damaged keel bones and of tibias in end-of-lay hens raised in loose housing systems. Bones were palpated and examined by peripheral quantitative computer tomography (PQCT, a three-point bending test, and analyses of bone ash. Contrary to our expectations, PQCT revealed higher cortical and trabecular contents in fractured than in intact keel bones. This might be due to structural bone repair after fractures. Density measurements of cortical and trabecular tissues of keel bones did not differ between individuals with and without fractures. In the three-point bending test of the tibias, ultimate shear strength was significantly higher in birds with intact vs. fractured keel bones. Likewise, birds with intact or slightly deviated keel bones had higher mineral and calcium contents of the keel bone than birds with fractured keel bones. Calcium content in keel bones was correlated with calcium content in tibias. Although there were some associations between bone traits related to bone strength and keel bone damage, other factors such as stochastic events related to housing such as falls and collisions seem to be at least as important for the prevalence of keel bone damage.
Shim, J H; Lee, Y S; Kim, M R; Lee, C J; Kim, I S
2003-10-10
We examined a Keele injector for sample introduction for gas chromatographic analysis of vinclozolin treated in lettuces. Samples in milligram quantity were introduced into a glass tube in a Keele injector at a gas chromatograph injection port. The glass tube was then crushed to allow the sample to carry onto a capillary column in a normal manner. The standard calibration curve for quantitative detection of vinclozolin was obtained by determining vinclozolin spiked in samples at variable concentrations. The calibration curve showed a linear response to vinclozolin ranging from 0.05 to 1.0 microg/g, giving a slope value of 174.8, the y-intercept value of -2.8146 and the mean r2-value of 0.9994. Limit of quantification for vinclozolin was 0.05 microg/g by this method, comparable to 0.01 microg/g by a normal injector. When samples treated previously with vinclozolin were determined by the Keele injector, vinclozolin was found to be about 30% lower as compared to a normal method, suggesting about 70% recovery of the spiked vinclozolin by the Keele injector. From these results, the Keele injector was suggested to be potential for sample introduction in gas chromatographic analysis of vinclozolin in lettuce samples.
Anisotropic tomography of the Indian continent and the geodynamic role of its keel
Montagner, J. P.; Maurya, S.; Sibrant, A.; Davaille, A.; Stutzmann, E.; Kumar, R.; Jean, B.
2017-12-01
The Indian moved at an exceptional high rate (18-20cm/year) after the birth of La Réunion hotspot, ≈65Ma ago and the Deccan volcanic province before the collision with the Asian continent. Other older plumes Marion, Kerguelen located in the Indian ocean are also associated with very fast plate motion. We present a high-resolution 3D anisotropic model of the Indian plate region down to 300 km depth, obtained by inverting a new massive database of surface-wave observations. The Rayleigh and Love wave dispersion measurements along 14,000 paths are made in a broad frequency range (16-250s). Our estimates of the depth to the Lithosphere-Asthenosphere Boundary (LAB) derived from seismic velocity Vsv variations at depth reveal large variations (120-250 km) beneath the different cratonic blocks. A low velocity layer associated with the Mid-lithospheric discontinuity is present when the root of the lithosphere is deep. This extensive anisotropic tomographic investigation of the Indian continent displays an almost north-south keel, 600km long and 300km wide, down to 250km depth. The keel is characterized by fast velocities, smaller than average radial and azimuthal anisotropies. The distribution of azimuthal anisotropy defines the flow lines around the keel, and, at the LAB, coincides with the APM direction of the Indian plate. The fast axis azimuths at 250 km depth are also in accordance with the results from SK(K)S splitting. Such a keel could probably perturb plume-induced flow in the asthenosphere. To determine the influence of such a keel on the interaction of India with several mantle plumes (Marion, Crozet, Kerguelen, La Réunion), we used laboratory experiments. Some preliminary results will be presented on the comparison between the laboratory flowlines and the direction of seismic anisotropy.
International Nuclear Information System (INIS)
Jiang Minhao; Meng Xujun
2005-01-01
The effect of the free electron background in plasmas is introduced in Hartree-Fock-Slater self-consistent field atomic model to correct the single electron energies for each electron configuration, and to provide accurate atomic data for Boltzmann-Saha equation. In the iteration process chemical potential is adjusted to change the free electron background to satisfy simultaneously the conservation of the free electrons in Saha equation as well as in Hartree-Fock-Slater self-consistent field atomic model. As examples the equations of state of the carbon and aluminum plasmas are calculated to show the applicability of this method. (authors)
Quantitative evaluation of SIMS spectra including spectrum interpretation and Saha-Eggert correction
International Nuclear Information System (INIS)
Steiger, W.; Ruedenauer, F.G.
1978-01-01
A spectrum identification program is described, using a computer algorithm which solely relies on the natural isotopic abundances for identification of elemental, molecular and cluster ions. The thermodynamic approach to the quantitative interpretation of SIMS spectra, through the use of the Saha-Eggert equation, is discussed, and a computer program is outlined. (U.K.)
Eesti keele grammatika ja sõnaraamat jaapanlastele / Enn Veldi
Veldi, Enn
1994-01-01
Arvustus: Matsumura, Kazuto. Eesti keele grammatika jaapanlastele. Tokyo : Institute for the Study of Languages and Cultures of Asia and Africa, 1991 ; Matsumura, Kazuto. Väike eesti-jaapani õppesõnaraamat. Tokyo : Institute for the Study of Languages and Cultures of Asia and Africa, 1991
Emotsioonid eesti keele käeväljendites / Ene Vainik
Vainik, Ene, 1964-
2010-01-01
Analüüsitakse eesti keele kõnelejate konventsionaalseid teadmisi ja ettekujutusi suhtlusprotsessist, uurides lähemalt leksikaalseid väljendeid, mille üheks komponendiks on viide käele (või selle osale)
Rootslanna Eestis kirjutas uue rootsi keele õpiku / Riina Noodapera
Noodapera, Riina, 1952-
2007-01-01
Carina Adolfssoni elust ja töötamisest Eestis. Rets. rmt.: Adolfsson, Carina. Sverige på svenska : lärobok i svenska för nybörjare : rootsi keele õpik algajatele : textbook in Swedish for beginners. Tallinn : Infotrükk, 2007. 179 lk.
Directory of Open Access Journals (Sweden)
Nela Durisic
2018-03-01
Full Text Available The GABAA receptor (GABAAR α1 subunit A295D epilepsy mutation reduces the surface expression of α1A295Dβ2γ2 GABAARs via ER-associated protein degradation. Suberanilohydroxamic acid (SAHA, also known as Vorinostat was recently shown to correct the misfolding of α1A295D subunits and thereby enhance the functional surface expression of α1A295Dβ2γ2 GABAARs. Here we investigated whether SAHA can also restore the surface expression of γ2 GABAAR subunits that incorporate epilepsy mutations (N40S, R43Q, P44S, R138G known to reduce surface expression via ER-associated protein degradation. As a control, we also investigated the γ2K289M epilepsy mutation that impairs gating without reducing surface expression. Effects of mutations were evaluated on inhibitory postsynaptic currents (IPSCs mediated by the major synaptic α1β2γ2 GABAAR isoform. Recordings were performed in neuron-HEK293 cell artificial synapses to minimise contamination by GABAARs of undefined subunit composition. Transfection with α1β2γ2N40S, α1β2γ2R43Q, α1β2γ2P44S and α1β2γ2R138G subunits produced IPSCs with decay times slower than those of unmutated α1β2γ2 GABAARs due to the low expression of mutant γ2 subunits and the correspondingly high expression of slow-decaying α1β2 GABAARs. SAHA pre-treatment significantly accelerated the decay time constants of IPSCs consistent with the upregulation of mutant γ2 subunit expression. This increase in surface expression was confirmed by immunohistochemistry. SAHA had no effect on either the IPSC kinetics or surface expression levels of α1β2γ2K289M GABAARs, confirming its specificity for ER-retained mutant γ2 subunits. We also found that α1β2γ2K289M GABAARs and SAHA-treated α1β2γ2R43Q, α1β2γ2P44S and α1β2γ2R138G GABAARs all mediated IPSCs that decayed at significantly faster rates than wild type receptors as temperature was increased from 22 to 40°C. This may help explain why these mutations cause febrile
Eesti keel barbarite suus / David J. Peterson ; intervjueerinud Peeter Helme
Peterson, David J.
2011-01-01
USA telekanali HBO telesarjas "Troonide mäng" (mis on George R. R. Martini "Jää ja tule laulu" sarja esimese raamatu "Troonide mäng" teleekraniseering) tegeles dothraki keele loomisega keeleteadlane David J. Peterson
Marx, Werner; Haunschild, Robin; French, Bernie; Bornmann, Lutz
2017-01-01
The Keeling curve has become a chemical landmark, whereas the papers by Charles David Keeling about the underlying carbon dioxide measurements are not cited as often as can be expected against the backdrop of his final approval. In this bibliometric study, we analyze Keeling's papers as a case study for under-citedness of climate change publications. Three possible reasons for the under-citedness of Keeling's papers are discussed: (1) The discourse on global cooling at the starting time of Keeling's measurement program, (2) the underestimation of what is often seen as "routine science", and (3) the amount of implicit/informal citations at the expense of explicit/formal (reference-based) citations. Those reasons may have contributed more or less to the slow reception and the under-citedness of Keeling's seminal works.
Korge, Andreas; Siepe, Christoph J; Heider, Franziska; Mayer, H Michael
2010-11-01
Dynamic intervertebral support of the cervical spine via an anterolateral approach using a modular artificial disk prosthesis with end-plate fixation by central keel fixation. Cervical median or mediolateral disk herniations, symptomatic cervical disk disease (SCDD) with anterior osseous, ligamentous and/or discogenic narrowing of the spinal canal. Cervical fractures, tumors, osteoporosis, arthrogenic neck pain, severe facet degeneration, increased segmental instability, ossification of posterior longitudinal ligament (OPLL), severe osteopenia, acute and chronic systemic, spinal or local infections, systemic and metabolic diseases, known implant allergy, pregnancy, severe adiposity (body mass index > 36 kg/m2), reduced patient compliance, alcohol abuse, drug abuse and dependency. Exposure of the anterior cervical spine using the minimally invasive anterolateral approach. Intervertebral fixation of retainer screws. Intervertebral diskectomy. Segmental distraction with vertebral body retainer and vertebral distractor. Removal of end-plate cartilage. Microscopically assisted decompression of spinal canal. Insertion of trial implant to determine appropriate implant size, height and position. After biplanar image intensifier control, drilling for keel preparation using drill guide and drill bit, keel-cut cleaner to remove bone material from the keel cut, radiologic control of depth of the keel cut using the corresponding position gauge. Implantation of original implant under lateral image intensifier control. Removal of implant inserter. Functional postoperative care and mobilization without external support, brace not used routinely, soft brace possible for 14 days due to postoperative pain syndromes. Implantation of 100 cervical Prodisc-C disk prostheses in 78 patients (average age 48 years) at a single center. Clinical and radiologic follow-up 24 months postoperatively. Significant improvement based on visual analog scale and Neck Disability Index. Radiologic
Dalamaga, Maria; Papadavid, Evangelia; Basios, Georgios; Vaggopoulos, Vassilios; Rigopoulos, Dimitrios; Kassanos, Dimitrios; Trakakis, Eftihios
2013-12-01
SAHA syndrome is characterized by the tetrad: seborrhea, acne, hirsutism, and androgenetic alopecia. No previous study has examined the prevalence of glucose abnormalities in ovarian SAHA and explored whether it may be an independent risk factor for glucose abnormalities. In a prospective controlled study, we investigated the spectrum of glucose abnormalities in ovarian SAHA and explored whether it is associated with a more insulin-resistant profile. In all, 316 patients with a diagnosis of polycystic ovary syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were examined and underwent a 2-hour oral glucose tolerance test. Serum glucose homeostasis parameters, hormones, and adipokines were determined. SAHA prevalence was 17.7% in patients with PCOS and predominance of the severe PCOS phenotype. Ovarian SAHA was independently associated with a more insulin-resistant profile (higher homeostatic model assessment of insulin resistance score, lower quantitative insulin sensitivity check index [QUICKI] and MATSUDA indices, and relative hypoadiponectinemia), and represented an independent risk factor for glucose abnormalities regardless of anthropometric features, age, and PCOS phenotype. There was no performance of skin biopsies. The prompt recognition of SAHA syndrome in women with PCOS permits an earlier diagnosis and surveillance of metabolic abnormalities, especially in Mediterranean PCOS population exhibiting a lower prevalence of glucose abnormalities. Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
International Nuclear Information System (INIS)
Chen, R.L.W.
1981-01-01
The use of an equation obtained earlier for computing electrical conductivity may be extended to partially ionized gases which depart from the Saha equation, provided the electron velocity distributions do not deviate from the Maxwellian distribution. (author)
14 sajandit lukus keel / Kätlin Hommik-Mrabte ; intervjueerinud Raivo Kaer
Hommik-Mrabte, Kätlin
2016-01-01
Hiljuti ilmus "Arabia keele vestmik-sõnastik", mis on koostatud nii eestlastele kui ka araabia keelt kõnelevatele inimestele, kes soovivad õppida eesti keelt. Intervjuu vestmiku autori Kätlin Hommik-Mrabtega
Heerkens, J.L.T.; Delezie, E.; Rodenburg, T.B.; Kempen, I.; Zoons, J.; Ampe, B.; Tuyttens, F.A.M.
2016-01-01
Aviary systems for laying hens offer space and opportunities to perform natural behaviors. However, hen welfare can be impaired due to increased risk for keel bone and foot pad disorders in those systems. This cross-sectional study (N = 47 flocks) aimed to assess prevalences of keel bone and foot
Hanson, Raimu, 1957-
2009-01-01
Hiina keeleteadlane Gao Jingyi on avaldanud raamatu, milles ta näitab, et hiina keel ning eesti keel ja teised läänemeresoome keeled mingil määral koos teiste uurali keeltega pärinevad ühisest allikast
Statistilise keelemudeli adapteerimine eesti keele kõnetuvastuses / Tanel Alumäe
Alumäe, Tanel, 1976-
2008-01-01
Käsitletakse eesti keele suure sõnavaraga kõnetuvastuse statistilise keelemudeli adapteerimist, mille käigus on võimalik varjatud semantika analüüsi abil leida suurest dokumendikorpusest antud teemale lähedasemad tekstid
Eesti-X-keele sõnastik ja grammatika / Ülle Viks
Viks, Ülle
2008-01-01
Käsitletakse kakskeelsetes sõnaraamatutes grammatilise info esitamisega seotud probleeme. Lähemalt tutvustatakse Eesti-X-keele sõnastikku (universaalne leksikaal-grammatiline andmebaas, mis võimaldab genereerida suvalise kakskeelse sõnaraamatu elektroonilist põhja), tema kohta sõnastike tüpoloogias ja sellest tulenevaid nõudeid
Directory of Open Access Journals (Sweden)
Lucjan Gucma
2017-09-01
Full Text Available The article presents a system for determining dynamic under keel clearance. In order to build a DRWPS system, a mixed model was created based on the analysis of math models. The system includes advisory software for defining the conditions for the entering of large LNG vessels in the context of under keel clearance and software was built to support the decision-making of operators who are responsible for introducing these vessels to the Port of Swinoujscie.
Läti koolilaste interferentsist eesti keele õppimisel / Marjo Mela
Mela, Marjo
2002-01-01
Artikli autor jälgis Riia Eesti kooli 1998. ja 1999.a. üheksanda klassi lõpetanute eesti keele õppega seotud probleeme. Riia Eesti kool on lätikeelne, peamine põhjus, miks vanemad oma lapsed eesti kooli panid, oli see, et kool on uus ja väike, etnilisusel ei olnud vanemate silmis tähtsust
Directory of Open Access Journals (Sweden)
Jia Meng
Full Text Available With the trend of an increasing aged population worldwide, Alzheimer's disease (AD, an age-related neurodegenerative disorder, as one of the major causes of dementia in elderly people is of growing concern. Despite the many hard efforts attempted during the past several decades in trying to elucidate the pathological mechanisms underlying AD and putting forward potential therapeutic strategies, there is still a lack of effective treatments for AD. The efficacy of many potential therapeutic drugs for AD is of main concern in clinical practice. For example, large bodies of evidence show that the anti-tumor histone deacetylase (HDAC inhibitor, suberoylanilidehydroxamic acid (SAHA, may be of benefit for the treatment of AD; however, its extensive inhibition of HDACs makes it a poor therapeutic. Moreover, the natural flavonoid, curcumin, may also have a potential therapeutic benefit against AD; however, it is plagued by low bioavailability. Therefore, the integrative effects of SAHA and curcumin were investigated as a protection against amyloid-beta neurotoxicity in vitro. We hypothesized that at low doses their synergistic effect would improve therapeutic selectivity, based on experiments that showed that at low concentrations SAHA and curcumin could provide comprehensive protection against Aβ25-35-induced neuronal damage in PC12 cells, strongly implying potent synergism. Furthermore, network analysis suggested that the possible mechanism underlying their synergistic action might be derived from restoration of the damaged functional link between Akt and the CBP/p300 pathway, which plays a crucial role in the pathological development of AD. Thus, our findings provided a feasible avenue for the application of a synergistic drug combination, SAHA and curcumin, in the treatment of AD.
Correlated evolution of sternal keel length and ilium length in birds
Directory of Open Access Journals (Sweden)
Tao Zhao
2017-07-01
Full Text Available The interplay between the pectoral module (the pectoral girdle and limbs and the pelvic module (the pelvic girdle and limbs plays a key role in shaping avian evolution, but prior empirical studies on trait covariation between the two modules are limited. Here we empirically test whether (size-corrected sternal keel length and ilium length are correlated during avian evolution using phylogenetic comparative methods. Our analyses on extant birds and Mesozoic birds both recover a significantly positive correlation. The results provide new evidence regarding the integration between the pelvic and pectoral modules. The correlated evolution of sternal keel length and ilium length may serve as a mechanism to cope with the effect on performance caused by a tradeoff in muscle mass between the pectoral and pelvic modules, via changing moment arms of muscles that function in flight and in terrestrial locomotion.
Dual-keel electrodynamic maglev system
He, Jianliang; Wang, Zian; Rote, Donald M.; Coffey, Howard T.; Hull, John R.; Mulcahy, Thomas M.; Cal, Yigang
1996-01-01
A propulsion and stabilization system with a plurality of superconducting magnetic devices affixed to the dual-keels of a vehicle, where the superconducting magnetic devices produce a magnetic field when energized. The system also includes a plurality of figure-eight shaped null-flux coils affixed to opposing vertical sides of slots in a guideway. The figure-eight shaped null-flux coils are vertically oriented, laterally cross-connected in parallel, longitudinally connected in series, and continue the length of the vertical slots providing levitation and guidance force. An external power source energizes the figure-eight shaped null-flux coils to create a magnetic traveling wave that interacts with the magnetic field produced by the superconducting magnets to impart motion to the vehicle.
Singh, Raushan K.; Lall, Naveena; Leedahl, Travis S.; McGillivray, Abigail; Mandal, Tanmay; Haldar, Manas; Mallik, Sanku; Cook, Gregory; Srivastava, D.K.
2013-01-01
Of the different hydroxamate-based histone deacetylase (HDAC) inhibitors, Suberoylanilide hydroxamic acid (SAHA) has been approved by the FDA for treatment of T-cell lymphoma. Interestingly, a structurally similar inhibitor, Trichostatin A (TSA), which has a higher in vitro inhibitory-potency against HDAC8, reportedly shows a poor efficacy in clinical settings. In order to gain the molecular insight into the above discriminatory feature, we performed transient kinetic and isothermal titration calorimetric studies for the interaction of SAHA and TSA to the recombinant form of human HDAC8. The transient kinetic data revealed that the binding of both the inhibitors to the enzyme showed the biphasic profiles, which represented an initial encounter of enzyme with the inhibitor followed by the isomerization of the transient enzyme-inhibitor complexes. The temperature-dependent transient kinetic studies with the above inhibitors revealed that the bimolecular process is primarily dominated by favorable enthalpic changes, as opposed to the isomerization step; which is solely contributed by entropic changes. The standard binding-enthalpy (ΔH0) of SAHA, deduced from the transient kinetic as well as the isothermal titration calorimetric experiments, was 2–3 kcal/mol higher as compared to TSA. The experimental data presented herein suggests that SAHA serves as a preferential (target-specific/selective) HDAC8 inhibitor as compared to TSA. Arguments are presented that the detailed kinetic and thermodynamic studies may guide in the rational design of HDAC inhibitors as therapeutic agents. PMID:24079912
Vene meestel ei tasu eesti keele õppimine ära / Mikk Salu
Salu, Mikk, 1975-
2011-01-01
Tartu Ülikooli majandusteaduskonna vanemteaduri Ott Toometi poolt läbiviidud analüüsist selgub, et vene naistele toob eesti keele oskamine palgalisa, aga meestele mitte. Vastav teadusartikkel on ilmunud ka ajakirjas American Economic Review. Riigikogu liikme Jevgeni Ossinovski arvamus
International Nuclear Information System (INIS)
Stock, S.R.; Barss, J.; Dahl, T.; Veis, A.; Almer, J.D.; De Carlo, F.
2003-01-01
In sea urchin teeth, the keel plays an important structural role, and this paper reports results of microstructural characterization of the keel of Lytechinus variegatus using two noninvasive synchrotron x-ray techniques: x-ray absorption microtomography (microCT) and x-ray diffraction mapping. MicroCT with 14 keV x-rays mapped the spatial distribution of mineral at the 1.3 microm level in a millimeter-sized fragment of a mature portion of the keel. Two rows of low absorption channels (i.e., primary channels) slightly less than 10 microm in diameter were found running linearly from the flange to the base of the keel and parallel to its sides. The primary channels paralleled the oral edge of the keel, and the microCT slices revealed a planar secondary channel leading from each primary channel to the side of the keel. The primary and secondary channels were more or less coplanar and may correspond to the soft tissue between plates of the carinar process. Transmission x-ray diffraction with 80.8 keV x-rays and a 0.1 mm beam mapped the distribution of calcite crystal orientations and the composition Ca(1-x)Mg(x)CO(3) of the calcite. Unlike the variable Mg concentration and highly curved prisms found in the keel of Paracentrotus lividus, a constant Mg content (x = 0.13) and relatively little prism curvature was found in the keel of Lytechinus variegatus.
Bamford, Adrian; Nation, Andy; Durrell, Susie; Andronis, Lazaros; Rule, Ellen; McLeod, Hugh
2017-02-03
The Keele stratified care model for management of low back pain comprises use of the prognostic STarT Back Screening Tool to allocate patients into one of three risk-defined categories leading to associated risk-specific treatment pathways, such that high-risk patients receive enhanced treatment and more sessions than medium- and low-risk patients. The Keele model is associated with economic benefits and is being widely implemented. The objective was to assess the use of the stratified model following its introduction in an acute hospital physiotherapy department setting in Gloucestershire, England. Physiotherapists recorded data on 201 patients treated using the Keele model in two audits in 2013 and 2014. To assess whether implementation of the stratified model was associated with the anticipated range of treatment sessions, regression analysis of the audit data was used to determine whether high- or medium-risk patients received significantly more treatment sessions than low-risk patients. The analysis controlled for patient characteristics, year, physiotherapists' seniority and physiotherapist. To assess the physiotherapists' views on the usefulness of the stratified model, audit data on this were analysed using framework methods. To assess the potential economic consequences of introducing the stratified care model in Gloucestershire, published economic evaluation findings on back-related National Health Service (NHS) costs, quality-adjusted life years (QALYs) and societal productivity losses were applied to audit data on the proportion of patients by risk classification and estimates of local incidence. When the Keele model was implemented, patients received significantly more treatment sessions as the risk-rating increased, in line with the anticipated impact of targeted treatment pathways. Physiotherapists were largely positive about using the model. The potential annual impact of rolling out the model across Gloucestershire is a gain in approximately 30
An analysis of the effect of endplates upon the fin keel of a sailing yacht
International Nuclear Information System (INIS)
Andrews, G.T.; Raiskums, C.L.; Keffer, J.F.
1985-01-01
A long-term investigation is presently underway to assess the overall performance of the modern design of fin keels for sailing yachts. An ultimate goal is to determine the specific advantages for such designs with respect to a centre-board configuration with outside ballast. The present preliminary studies were carried out to determine the basic performance of a typical fin keel shape for various values of leeway angle. A second aspect was to determine the effect upon this baseline performance of a number of endplates of varying sizes and shapes. (author)
Eesti keele õpik ja töövihik vene õppekeelega gümnaasiumi 11. klassile / Malle Rüütli, Ele Viilipus
Rüütli, Malle, 1952-
2008-01-01
Raamatutest: Rüütli, Malle; Viilipus, Ele. Eesti keele õpik vene õppekeelega gümnaasiumi 11. klassile. Rüütli, Malle; Viilipus, Ele. Eesti keele töövihik vene õppekeelega gümnaasiumi 11. klassile
Keeled ja nende kõnelejad keskaegses Tallinnas : edenemine või taandareng? / Tiina Kala
Kala, Tiina, 1967-
2004-01-01
Keelesituatsioonist Tallinna arengu algusaastatel, 13.-14. saj. ametlikest dokumentidest kuni 16. saj. õiguslike materjalideni, reformatsiooni mõjudest eesti keele positsioonile kirikusiseses keelekasutuses. Eestis kõneldud keelte staatusest keskajal
International Nuclear Information System (INIS)
Wang, Weizong; Rong, Mingzhe; Spencer, Joseph W.
2013-01-01
This paper focuses to study how the choice of Guldberg-Waage and Saha equations affects the thermodynamic properties and transport coefficients of SF 6 plasmas under both thermal equilibrium and non-equilibrium conditions. The species composition is numerically determined using two typical forms of two-temperature Saha equations and Guldberg-Waage equations that have appeared in the literature. The great influence of the choice of the excitation temperature on the plasma composition and hence the thermodynamic properties and transport coefficients is discussed as well. Transport coefficients are calculated with most recent collision interaction potentials by adopting Devoto's electron and heavy particle decoupling approach but expanded to the third-order approximation (second-order for viscosity) within the framework of Chapman-Enskog method. Furthermore, an analysis of the effect of different definitions of Debye length on the properties values was performed as well. The results are computed for various values of pressures from 0.10 atm to 10 atm and non-equilibrium parameter, i.e., ratio of the electron temperature to the heavy particle temperature from 1 to 5 with electron temperature range from 300 to 40 000 K. Both forms of Guldberg-Waage and Saha equations used here can give completely the same value when the two-temperature model reaches the special case of local thermodynamic equilibrium. It has been observed that all above mentioned factors can significantly modify the plasma species composition and consequently affect the thermodynamic and transport properties
Chen, Jian; Shi, Fang; Chen, Min; Yang, Yue; Cheng, Lei; Wu, Haitao
2017-10-01
This work is a retrospective analysis to investigate the critical risk factor for the therapeutic effect of endoscopic keel placement on anterior glottic web. Altogether, 36 patients with anterior glottic web undergoing endoscopic lysis and silicone keel placement were enrolled. Their voice qualities were evaluated using the voice handicap index-10 (VHI-10) questionnaire, and improved significantly 3 months after surgery (21.53 ± 3.89 vs 9.81 ± 6.68, P web recurrence during the at least 1-year follow-up. Therefore, patients were classified according to the Cohen classification or web thickness, and the recurrence rates were compared. The distribution of recurrence rates for Cohen type 1 ~ 4 were 28.6, 16.7, 33.3, and 40%, respectively. The difference was not statistically significant (P = 0.461). When classified by web thickness, only 2 of 27 (7.41%) thin type cases relapsed whereas 8 of 9 (88.9%) cases in the thick group reformed webs (P web thickness rather than the Cohen grades. Endoscopic lysis and keel placement is only effective for cases with thin glottic webs. Patients with thick webs should be treated by other means.
Puksand, Helin, 1970-
2015-01-01
Eesti õpivarale antud rahvusvahelised auhinnad: Best European Learning Material Silver Award 2014 Helin Puksandi, Reet Bobõlski ja Margit Rossi eesti keele õpikule "Punkt" (2013) ja Best European Schoolbook Silver Award 2012 samade autorite eesti keele õpikule "Peegel 3" (2011). Best European Schoolbook Bronze Award 2006 Jaanus Vaiksoo, Sirje Toomla ja Kadri Liivese aabitsale "Ilus emakeel" (2005).
Causes of keel bone damage and their solutions in laying hens
Harlander-Matauschek, A.; Rodenburg, T.B.; Sandilands, V.; Tobalske, B.W.; Toscano, M.J.
2015-01-01
Keel bone damage (KBD) is a critical issue facing the contemporary laying hen industry due to the likely pain leading to compromised welfare and reduced productivity. Recent reports suggest that KBD, while highly variable and likely dependent on a host of factors, extends to all housing systems
Veismann, Ann, 1972-
2008-01-01
Käsitletakse eesti keele ühendverbe, nende seaduspärasusi ning tähenduse omandamist vastavalt sellele, millise afiksaaladverbiga nad on moodustatud. Samuti afiksaaladverbist kui eesti ja teiste keelte aspekti väljendusvahendist
Wang, Yan; Tu, Sheng; Steffen, Dana; Xiong, May
2014-01-01
The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic acid (SAHA) and LAQ824 (LAQ) prior to their encapsulation into PEGylated liposomes, and investigated whether this technique could improve drug solubility, in vitro release and in vivo pharmacokinetic (PK) properties. METHODS. The reaction stoichiometry, binding constants and solubility were measured for Fe complexes of SAHA and LAQ. The complexes were passively encapsulated into PEGylated liposomes and characterized by size distribution, zeta-potential, encapsulation efficiency (EE), and in vitro drug release studies. PC-3 cells were used to verify the in vitro anticancer activity of the formulations. In vivo pharmacokinetic properties of liposomal LAQ-Fe (L-LAQ-Fe) was evaluated in rats. RESULTS. SAHA and LAQ form complexes with Fe at 1:1 stoichiometric ratio, with a binding constant on the order of 104 M-1. Fe complexation improved the aqueous solubility and the liposomal encapsulation efficiency of SAHA and LAQ (29-35% EE, final drug concentration > 1 mM). Liposomal encapsulated complexes (L-HDACi-Fe) exhibited sustained in vitro release properties compared to L-HDACi but cytotoxicity on PC-3 cells was comparable to free drugs. The PK of L-LAQ-Fe revealed 15-fold improvement in the plasma t1/2 (12.11 h)and 211-fold improvement in the AUC∞ (105.7 µg·h/ml) compared to free LAQ (0.79 h, 0.5 µg·h/ml). Similarly, the plasma t1/2 of Fe was determined to be 11.83 h in a separate experiment using radioactive Fe-59. The majority of Fe-59 activity was found in liver and spleen of rats and correlates with liposomal uptake by the mononuclear phagocyte system. CONCLUSIONS. We have demonstrated that encapsulation of Fe complexes of HDACi into PEGylated liposomes can improve overall drug aqueous solubility, in vitro release and in
Nonuniqueness of the two-temperature Saha equation and related considerations
International Nuclear Information System (INIS)
Giordano, D.; Capitelli, M.
2002-01-01
The present paper contains considerations relative to the long debated thermodynamic derivation of two-temperature Saha equations. The main focus of our discourse is on the dependence of the multitemperature equilibrium conditions on the constraints imposed on the thermodynamic system. We also examine the following key issues related to that dependence: correspondence between constraints and equilibrium-equation forms that have appeared in the literature; presumed dominance of the free-electron translational temperature in the two-temperature expression of the equilibrium constant of the ionization reaction A A + +e - ; disagreement between the derivation methods based on, respectively, the extended second law of classical thermodynamics and axiomatic thermodynamics; and plausibility of the existence of entropic constraints
„Keel läbi kultuuri” Haabersti vene gümnaasiumis / Julia Bandura
Bandura, Julia
2012-01-01
Eesti rahva kultuuripärandi tutvustamisest gümnaasiumis läbi projekti „Keel läbi kultuuri”, mille eesmärk oli toetada vene põhikoolilõpetanute kohanemist ja toimetulekut eestikeelse õppega gümnaasiumiastmes
Lacraz, Alain; Armand, Stéphane; Turcot, Katia; Carmona, Gorki; Stern, Richard; Borens, Olivier; Assal, Mathieu
2017-06-01
The International Committee of the Red Cross supports a worldwide program of prosthetic fitting and rehabilitation. In this context, a prosthetic foot was developed and widely distributed in least developed countries. Prospective, randomized, double-blind, controlled study. To compare patient satisfaction and energy expenditure during ambulation between a low-cost prosthetic foot designed with a polypropylene keel (CR-Equipements ™ solid ankle cushion heel, International Committee of the Red Cross) to a well-recognized solid ankle cushion heel foot with a wooden keel (solid ankle cushion heel foot, Otto Bock). A total of 15 participants with unilateral transtibial amputation were evaluated using the two prosthetic feet in a randomized prospective double-blind crossover study. Main outcomes were patient satisfaction questionnaires (Satisfaction with Prosthesis Questionnaire and prosthetic foot satisfaction) and energy expenditure (oxygen consumption-mL/kg/min, oxygen cost-mL/kg/m, and heart rate-bpm). There were no significant differences between the two prosthetic feet for satisfaction and energy expenditure. The low-cost solid ankle cushion heel foot with polypropylene keel provides comparable satisfaction and similar energy expenditure as the solid ankle cushion heel foot with wooden keel. Clinical relevance The results of this study support the application and widespread use of the CR-Equipements ™ solid ankle cushion heel foot. From a cost-effectiveness standpoint, patients are well satisfied and exhibit similar outcomes at a substantially lower cost.
Asgar, Md Ali; Senawong, Gulsiri; Sripa, Banchob; Senawong, Thanaset
2016-01-01
Clinical application of cisplatin against cholangiocarcinoma is often associated with resistance and toxicity posing urgent demand for combination therapy. In this study, we evaluated the combined anticancer effect of cisplatin and histone deacetylase inhibitors (HDACIs), suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), on the cholangiocarcinoma KKU-100 and KKU-M214 cell lines. Antiproliferative activity was evaluated using MTT assay. Apoptosis induction and cell cycle arrest were analyzed by flow cytometry. Cell cycle and apoptosis regulating proteins were evaluated by western blot analysis. MTT assay showed that cisplatin, SAHA and TSA dose-dependently reduced the viability of KKU-100 and KKU-M214 cells. The combination of cisplatin and HDACIs exerted significantly more cytotoxicity than the single drugs. Combination indices below 1.0 reflect synergism between cisplatin and HDACIs, leading to positive dose reductions of cisplatin and HDACIs. Cisplatin and HDACIs alone induced G0/G1 phase arrest in KKU-100 cells, but the drug combinations increased sub-G1 percent more than either drug. However, cisplatin and HDACIs alone or in combination increased only the sub-G1 percent in KKU-M214 cells. Annexin V-FITC staining revealed that cisplatin and HDACIs combinations induced more apoptotic cell death of both KKU-100 and KKU-M214 cells than the single drug. In KKU-100 cells, growth inhibition was accompanied by upregulation of p53 and p21 and downregulation of CDK4 and Bcl-2 due to exposure to cisplatin, SAHA and TSA alone or in combination. Moreover, combination of agents exerted higher impacts on protein expression. Single agents or combination did not affect p53 expression, however, combination of cisplatin and HDACIs increased the expression of p21 in KKU-M214 cells. Taken together, cisplatin and HDACIs combination may improve the therapeutic outcome in cholangiocarcinoma patients.
Metalingvistiline teadlikkus võõrkeeleõppes : oma keel võõras peeglis / Annekatrin Kaivapalu
Kaivapalu, Annekatrin, 1963-
2010-01-01
Uuritakse, milliseid tähelepanekuid teeb õppija võõrkeeli õppides oma emakeele, antud juhul eesti ja soome keele kohta ning kas ja millises osas ühtivad õppijate arusaamad keelte lingvistiliste kirjeldustega
Saks, Katrin, 1968-
2015-01-01
Tehnoloogiliste vahenditega tõhustatud võõrkeelekursuse raames välja töötatud sekkumisest, mis võimaldab õpetajal parimal moel toetada õppijate kognitiivseid ja metakognitiivseid keele- õppestrateegiaid
Observations of Hydraulic Roughness and Form Drag in the Wake of a Deep Ice Keel in the Arctic Ocean
2012-03-01
bottom morphology, ( Bourke and Mclaren 1992; Davis and Wadhams 1995) have been based on data obtained from upward-looking and side scan sonar systems...submarine voyages, Bourke and McLaren (1992), calculated during the summer there are 1–3 keels with drafts greater than 9 m per kilometer, and during...Implementing variable |Cw| values coupled with ice keel surveys such as the ones mentioned above ( Bourke and McLaren 1992; Davis and Wadhams 1995) is a
Directory of Open Access Journals (Sweden)
Hai-Shu Lin
2013-11-01
Full Text Available MS-275 (entinostat and SAHA (vorinostat, two histone deacetylase (HDAC inhibitors currently in oncological trials, have displayed potent anti-rheumatic activities in rodent models of rheumatoid arthritis (RA. To further elucidate their anti-inflammatory mechanisms, the impact of MS-275 and SAHA on the p38 mitogen-activated protein kinase (MAPK signaling pathway and chemotaxis was assessed in human rheumatoid arthritic synovial fibroblastic E11 cells. MS-275 and SAHA significantly suppressed the expression of p38α MAPK, but induced the expression of MAPK phosphatase-1 (MKP-1, an endogenous suppressor of p38α in E11 cells. At the same time, the association between p38α and MKP-1 was up-regulated and consequently, the activation (phosphorylation of p38α was inhibited. Moreover, MS-275 and SAHA suppressed granulocyte chemotactic protein-2 (GCP-2, monocyte chemotactic protein-2 (MCP-2 and macrophage migration inhibitory factor (MIF in E11 cells in a concentration-dependent manner. Subsequently, E11-driven migration of THP-1 and U937 monocytes was inhibited. In summary, suppression of the p38 MAPK signaling pathway and chemotaxis appear to be important anti-rheumatic mechanisms of action of these HDAC inhibitors.
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Beryl Katharina Eusemann
Full Text Available A high prevalence of deviations and fractures of the keel bone is a widespread welfare problem in laying hens. The aim of this study was to experimentally investigate this multifactorial problem throughout the laying period and to compare the prevalence and severity in different layer lines and different housing systems. High performing white (WLA and brown (BLA pure bred layer lines and low performing white (R11, G11 and brown layer lines (L68 were kept in both single cages and a floor housing system. A total of 97 hens (19 or 20 from each line, respectively were repeatedly radiographed in the 35th, 51st and 72nd week of age. Fracture prevalence increased with age (p<0.001. The proportion of deviated keel bone area increased only for caged BLA, WLA and R11 hens (p<0.05 and was significantly higher for caged WLA and R11 hens compared to floor-housed WLA and R11 hens in the 72nd week of age (p<0.05. In the 72nd week of age hens in the floor housing system showed significantly more fractures than hens kept in cages (p<0.05. Prevalence of keel bone deviations was significantly higher in the white layer line R11 but significantly lower in the white layer line G11 compared to both brown layer lines and WLA (p<0.05. Brown layers showed significantly more fractures than white layers (p<0.05 in the 51st and 72nd week of age. Within the brown layers there was a significantly lower prevalence of deviations (p<0.05 and fractures (p<0.05 in the low performing (L68 compared to the high performing line (BLA. Our results show a different development of keel bone damage in caged compared to floor-housed hens under experimental conditions. Additionally, they indicate genetic effects on keel bone damage.
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Humaira Majeed Khan1, Muhammad Ashraf2, Abu Saeed Hashmi3, Mansur-ud-Din Ahmad4 and Aftab Ahmad Anjum5
2013-11-01
Full Text Available The present study was conducted to explore the potential and cheaper source of major and abundantly found sulphated glycosaminoglycans (GAGs in chicken keel cartilage. Chicken is comparatively readily accessible to all the communities of Pakistan and its cartilages are the rich source of sulphated GAGs. The GAGs were extracted from prewashed and ground keel cartilages (n=3 of chicken using 3 M MgCl2, dialyzed, digested with papain, precipitated with three volumes of ethanol, and finally lyophilized to dry powder. The dry products were used for proximate analysis (carbohydrates 65.49±0.10, crude protein 12.82±0.26, ash 11.12±.56, moisture 9.88±0.32 and fat 0.69±0.14%. Dimethylmethylene blue binding (DMMB assay was performed to determine the quantity of total GAGs in each group of product and protein contents were estimated by Bradford method. Identification of extracted samples of GAGs was performed with FTIR spectrometer using KBr disc and purity of the samples was determined by SDS-PAGE. Quantity of total GAGs in extracted samples was 70.77±2.27% and estimated amount of protein was 4.64±0.29%. FTIR spectra of standard and samples of CS showed identical and characteristic peaks in finger print region. Finger print region revealed the presence of C-O-S, S=O, -COO, -C-C, R-SO2–R, -CONH2 and R-SO2-NH2 molecules. SDS-PAGE analysis revealed the presence of 77.8 and 50.5 kDa proteins in all extracted samples of GAGs. It can be concluded that chicken keel cartilage is the potential and cheap source of GAGs. Analysis by SDS-PAGE revealed that most of the non-collagen protein can be removed by three volumes of solvent extraction and FTIR is an advance technique for identification of GAGs in mid infrared region (400-4000 cm-1.
Hennoste, Tiit, 1953-
2009-01-01
Tutvustatakse Tartu Ülikooli suulise eesti keele korpuse ehitust, transkribeerimise põhimõtteid ja dialoogiaktide annoteerimiseks kasutatavat tüpoloogiat. Inimese ja arvuti vahelise suhtluse rakendusena analüüsitakse ametiasutustesse helistavate klientide esmaseid päringuid
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Binhua Ling
Full Text Available Viral reservoirs-persistent residual virus despite combination antiretroviral therapy (cART-remain an obstacle to cure of HIV-1 infection. Difficulty studying reservoirs in patients underscores the need for animal models that mimics HIV infected humans on cART. We studied SIV-infected Chinese-origin rhesus macaques (Ch-RM treated with intensive combination antiretroviral therapy (cART and 3 weeks of treatment with the histone deacetyalse inhibitor, suberoylanilide hydroxamic acid (SAHA.SIVmac251 infected Ch-RM received reverse transcriptase inhibitors PMPA and FTC and integrase inhibitor L-870812 beginning 7 weeks post infection. Integrase inhibitor L-900564 and boosted protease inhibitor treatment with Darunavir and Ritonavir were added later. cART was continued for 45 weeks, with daily SAHA administered for the last 3 weeks, followed by euthanasia/necropsy. Plasma viral RNA and cell/tissue-associated SIV gag RNA and DNA were quantified by qRT-PCR/qPCR, with flow cytometry monitoring changes in immune cell populations.Upon cART initiation, plasma viremia declined, remaining <30 SIV RNA copy Eq/ml during cART, with occasional blips. Decreased viral replication was associated with decreased immune activation and partial restoration of intestinal CD4+ T cells. SAHA was well tolerated but did not result in demonstrable treatment-associated changes in plasma or cell associated viral parameters.The ability to achieve and sustain virological suppression makes cART-suppressed, SIV-infected Ch-RM a potentially useful model to evaluate interventions targeting residual virus. However, despite intensive cART over one year, persistent viral DNA and RNA remained in tissues of all three animals. While well tolerated, three weeks of SAHA treatment did not demonstrably impact viral RNA levels in plasma or tissues; perhaps reflecting dosing, sampling and assay limitations.
Energy Technology Data Exchange (ETDEWEB)
Takada, N. [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Sato, T. [Tokyo Univ. (Japan)
1998-12-31
The computational fluid dynamics (CFD) is so remarkably developed in the various kinds of science and technology fields that it is utilized in aeroplane and other machines and structures. The introduction of Navier-Stokes equation into the fixed coordinate system makes it possible to perform the CFD simulation of vigorously moving body. Combining its procedure with the moving grid scheme enables us to maneuver a moving wing. A body with complicated shape like the keel of racing yacht is expressed by the multi-block grid to develop the CFD code corresponding to it. The simulation of forced motion, which is the first step of the motion simulation system, is applied to the keel of racing yacht to prove that the viscous flow field around the complicatedly shaped body. 6 refs., 17 figs., 2 tabs.
Meie seast on lahkunud saksa keele tõlk Rita Tasa : [3.12.1930-16.07.2007
2007-01-01
Järelhüüe kirjandusteadlasele, Tartu Ülikooli saksa kirjanduse õppejõule, Tallinna Pedagoogilise Instituudi saksa ja maailmakirjanduse õppejõule, saksa keele kadeedri juhatajale, saksa, šveitsi ning austria kirjanduse tõlkijale Rita Tasale
"Kas su keel kuuleb sind enam..." : [luuletused] / Jaan Kaplinski
Kaplinski, Jaan, 1941-
2003-01-01
Sisu: "Kas su keel kuuleb sind enam..." ; "Kui maailm teabki..." ; "Iga kevadega on taevas madalam ja trepid kõrgemad..." ; "Mis on sõnade vahel on aina enam kui sõnad ise..." ; "Palve on nüüd see mis jääb järele..." ; "Keegi ei maga kellegagi sama und..." ; "Niipalju nimesid miska olen nimetanud..." ; "Äkitselt nagu karjatades hakkab vesi kannus keema..." ; "Kui hea on mõelda et kõik see ilu pole kellegi jaoks..." ; "See kelle uni me oleme kuidas ta jättis meid siia..." ; "Enne kui teeme tule ära korjan lambi alt liblikad kokku..." ; "Raamatud pööravad meie poole seljad..." ; "Kõik mis me ehitame ehitame millegi rusudest..."
Directory of Open Access Journals (Sweden)
Angga Yustiawan
2013-09-01
Full Text Available One of the components of the Indonesia Tsunami Early Warning System (InaTEWS is a surface buoy. The surface buoy is exposed to dynamic and random loadings while operating at sea, particularly due to waves. Because of the cyclic nature of the wave load, this may result in a fatigue damage of the keel structure, which connects the mooring line with the buoy hull. The operating location of the buoy is off the Java South Coast at the coordinate (10.3998 S, 108.3417 E. To determine the stress transfer function, model tests were performed, measuring the buoy motions and the stress at the mooring line. A spectral fatigue analysis method is applied for the purpose of estimating the fatigue life of the keel structure. Utilizing the model-test results, the S-N curve obtained in a previous study and the wave data at the buoy location, it is found that the fatigue life of the keel structure is approximately 11 years.
Johnson, Jennifer; Pahuja, Anil; Graham, Melanie; Hering, Bernhard; Hancock, Wayne W.; Pratima, Bansal-Pakala
2008-01-01
SAHA, a histone deacetylase inhibitor (HDACi), is clinically approved for treatment of cutaneous T-cell lymphoma. Although the exact underlying mechanisms are unknown, HDACi arrest the cell cycle in rapidly proliferating tumor cells and promote their apoptosis. HDACi were also recently shown to enhance the production and suppressive functions of Foxp3+ regulatory T (Treg) cells in rodents, leading us to begin to investigate the actions of HDACi on rhesus monkey T cells for the sake of potenti...
Läänemeresoome keelte õppetoolis : soome keele olümpiaad Agricola päeval / Maris Amon
Amon, Maris
2000-01-01
7. aprillil Agricola päeva tähistava soome keele olümpiaadi korraldusega on Tallinna Pedagoogikaülikoolist seotud professor Jaan Õispuu žürii koosseisus, olümpiaadi ülesandeid koostavad õppejõud Maria-Magdalena Jürvetson ja Tarja Tanttu
The aero- and hydromechanics of keel yachts
Slooff, J W
2015-01-01
How and why does sail boat performance depend on the configuration and trim of boat and sails? This book provides the yachtsman with answers in a relatively straightforward account of the physical mechanisms of sailing. It presents an accessible overview of the fluid dynamic aspects of sailing and sailing technology, addressing both aeromechanics and hydromechanics. Readers are provided with the basic principles of physics and general mechanics that will assist their understanding of the fluid mechanics of sailing yachts. Rich appendices cover not only in-depth, mathematical-physical treatments and derivations for those wishing to explore further, but also helpful summaries of basic mathematical notions for those wishing to refresh their knowledge. This work explores keel yachts, specifically single-masted mono-hulls with ‘fore-and-aft’, Bermuda-rigged sails. However, much of it is applicable to other types of sailing vessels such as multi-hulls, yachts with multiple masts, windsurf boards and the li...
Harnessing the best of Europe to understand and solve Keel Bone Damage: An ongoing EU-COST Action
DEFF Research Database (Denmark)
Riber, Anja Brinch; Sandilands, Victoria; Toscano, M.
2017-01-01
on a specific topic, i.e., the causes of KBD and solutions to reduce their severity and frequency. The Action brings various participants with a diverse mix of disciplines together to facilitate novel and trans-disciplinary discussions that will lead to definitive and quantifiable outputs. In addition......The KeelBoneDamage COST Action seeks to provide the European laying hen industry with the innovations in breeding, nutrition, and management necessary to resolve the problem of keel bone damage (KBD) in order to meet the high standards of welfare and productivity demanded by the European community...... to pursuing these research objectives, the Action also seeks to strengthen European research capacity by connecting relevant scientific communities and providing networking opportunities for young scientists. Activities are performed in concert with industrial partners whom are leaders in the field ensuring...
International Nuclear Information System (INIS)
Iosilevskii, I.L.; Gryaznov, V.K.
1982-01-01
The relation between two methods of thermodynamical calculation of matter in the gas-plasma region is analyzed. These methods are the traditional one, which uses the Saha ionization equilibrium equation, and extrapolation of the Thomas--Fermi approximation with quantum and exchange corrections. These approximations are compared with one another, and also with the results of exact theory at the total ionization limit and with experimental data for a cesium plasma in the partial-ionization region
Sjögren, Wiedemann ja liivi keele sõnaraamat. Panus 19. sajandi teadusajalukku / Eberhard Winkler
Winkler, Eberhard, 1955-
2009-01-01
Uuritakse, milline võis olla kummagi teadlase osa esimese liivi keele sõnaraamatu koostamisel: Sjögren, Andreas Johan. Gesammelte Schriften. Band II. Theil I., Joh. Andreas Sjögren's Livische Grammatik nebst Sprachproben ; Band II. Theil II., Joh. Andreas Sjögren's livisch-deutsches und deutsch-livisches Wörterbuch / bearbeitet von Ferdinand Joh. Wiedemann. St. Petersburg, 1861
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Barbora Brodská
2013-01-01
Full Text Available Epigenetic therapy reverting aberrant acetylation or methylation offers the possibility to target preferentially tumor cells and to preserve normal cells. Combination epigenetic therapy may further improve the effect of individual drugs. We investigated combined action of demethylating agent decitabine and histone deacetylase inhibitor SAHA (Vorinostat on different leukemic cell lines in comparison with peripheral blood lymphocytes. Large decrease of viability, as well as huge p21WAF1 induction, reactive oxygen species formation, and apoptotic features due to combined decitabine and SAHA action were detected in leukemic cell lines irrespective of their p53 status, while essentially no effect was observed in response to the combined drug action in normal peripheral blood lymphocytes of healthy donors. p53-dependent apoptotic pathway was demonstrated to participate in the wtp53 CML-T1 leukemic cell line response, while significant influence of reactive oxygen species on viability decrease has been detected in p53-null HL-60 cell line.
Ariese, C.E.
2011-01-01
The existence of an unidentified 18th century Dutch shipwreck emerges periodically in books, letters and conversations about Christmas Island and the Cocos (Keeling) Islands. An investigation of these sources indicated that different ships may be responsible for these rumours, but it is equally
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P. Köhler
2006-01-01
Full Text Available The Keeling plot analysis is an interpretation method widely used in terrestrial carbon cycle research to quantify exchange processes of carbon between terrestrial reservoirs and the atmosphere. Here, we analyse measured data sets and artificial time series of the partial pressure of atmospheric carbon dioxide (pCO2 and of δ13C of CO2 over industrial and glacial/interglacial time scales and investigate to what extent the Keeling plot methodology can be applied to longer time scales. The artificial time series are simulation results of the global carbon cycle box model BICYCLE. The signals recorded in ice cores caused by abrupt terrestrial carbon uptake or release loose information due to air mixing in the firn before bubble enclosure and limited sampling frequency. Carbon uptake by the ocean cannot longer be neglected for less abrupt changes as occurring during glacial cycles. We introduce an equation for the calculation of long-term changes in the isotopic signature of atmospheric CO2 caused by an injection of terrestrial carbon to the atmosphere, in which the ocean is introduced as third reservoir. This is a paleo extension of the two reservoir mass balance equations of the Keeling plot approach. It gives an explanation for the bias between the isotopic signature of the terrestrial release and the signature deduced with the Keeling plot approach for long-term processes, in which the oceanic reservoir cannot be neglected. These deduced isotopic signatures are similar (−8.6‰ for steady state analyses of long-term changes in the terrestrial and marine biosphere which both perturb the atmospheric carbon reservoir. They are more positive than the δ13C signals of the sources, e.g. the terrestrial carbon pools themselves (−25‰. A distinction of specific processes acting on the global carbon cycle from the Keeling plot approach is not straightforward. In general, processes related to biogenic fixation or release of carbon have lower y
Doktoriväitekiri komi keele kohakäänete ruumisemantikast / Galina Nekrassova
Nekrassova, Galina
2013-01-01
27. dets. 2012. a. kaitses Nikolay Kuznetsov Tartu ülikooli eesti ja üldkeeleteaduse instituudis doktoriväitekirja "Пространственная семантика местных падежей коми языка (когнитивный анализ)" ("Komi keele kohakäänete ruumisemantika (kognitiivne analüüs)")
International Nuclear Information System (INIS)
Sodha, M. S.; Mishra, S. K.
2011-01-01
The authors have discussed the validity of Saha's equation for the charging of negatively charged spherical particles in a complex plasma in thermal equilibrium, even when the tunneling of the electrons, through the potential energy barrier surrounding the particle is considered. It is seen that the validity requires the probability of tunneling of an electron through the potential energy barrier surrounding the particle to be independent of the direction (inside to outside and vice versa) or in other words the Born's approximation should be valid.
Basu, Uma; De, Soumen
2015-01-01
The book is based on research presentations at the international conference, “Emerging Trends in Applied Mathematics: In the Memory of Sir Asutosh Mookerjee, S.N. Bose, M.N. Saha, and N.R. Sen”, held at the Department of Applied Mathematics, University of Calcutta, during 12–14 February 2014. It focuses on various emerging and challenging topics in the field of applied mathematics and theoretical physics. The book will be a valuable resource for postgraduate students at higher levels and researchers in applied mathematics and theoretical physics. Researchers presented a wide variety of themes in applied mathematics and theoretical physics—such as emergent periodicity in a field of chaos; Ricci flow equation and Poincare conjecture; Bose–Einstein condensation; geometry of local scale invariance and turbulence; statistical mechanics of human resource allocation: mathematical modelling of job-matching in labour markets; contact problem in elasticity; the Saha equation; computational fluid dynamics with...
KEELE, Minimization of Nonlinear Function with Linear Constraints, Variable Metric Method
International Nuclear Information System (INIS)
Westley, G.W.
1975-01-01
1 - Description of problem or function: KEELE is a linearly constrained nonlinear programming algorithm for locating a local minimum of a function of n variables with the variables subject to linear equality and/or inequality constraints. 2 - Method of solution: A variable metric procedure is used where the direction of search at each iteration is obtained by multiplying the negative of the gradient vector by a positive definite matrix which approximates the inverse of the matrix of second partial derivatives associated with the function. 3 - Restrictions on the complexity of the problem: Array dimensions limit the number of variables to 20 and the number of constraints to 50. These can be changed by the user
The Role of Water in the Stability of Cratonic Keels
Peslier, Anne H.; Woodland, Alan B.; Bell, David R.; Lazarov, Marina
2011-01-01
Cratons are typically underlain by large, deep, and old lithospheric keels (to greater than 200 km depth, greater than 2.5 Ga old) projecting into the asthenosphere (e.g., Jordan, 1978; Richardson et al., 1984). This has mystified Earth scientists as the dynamic and relatively hot asthenosphere should have eroded away these keels over time (e.g., Sleep, 2003; O'Neill et al., 2008; Karato, 2010). Three key factors have been invoked to explain cratonic root survival: 1) Low density makes the cratonic mantle buoyant (e.g., Poudjom Djomani et al., 2001). 2) Low temperatures (e.g., Pollack, 1986; Boyd, 1987), and 3) low water contents (e.g., Pollack, 1986), would make cratonic roots mechanically strong. Here we address the mechanism of the longevity of continental mantle lithosphere by focusing on the water parameter. Although nominally anhydrous , olivine, pyroxene and garnet can accommodate trace amounts of water in the form of H bonded to structural O in mineral defects (e.g., Bell and Rossman, 1992). Olivine softens by orders of magnitude if water (1-1000 ppm H2O) is added to its structure (e.g., Mackwell et al., 1985). Our recent work has placed constraints on the distribution of water measured in peridotite minerals in the cratonic root beneath the Kaapvaal in southern Africa (Peslier et al., 2010). At P greater than 5 GPa, the water contents of pyroxene remain relatively constant while those of olivine systematically decrease from 50 to less than 10 ppm H2O at 6.4 GPa. We hypothesized that at P greater than 6.4 GPa, i.e. at the bottom of the cratonic lithosphere, olivines are essentially dry (greater than 10 ppm H2O). As olivine likely controls the rheology of the mantle, we calculated that the dry olivines could be responsible for a contrast in viscosity between cratonic lithosphere and surrounding asthenosphere large enough to explain the resistance of cratonic root to asthenospheric delamination.
Sumo Friend Tambunan, Usman; Bakri, Ridla; Aditya Parikesit, Arli; Ariyani, Titin; Dyah Puspitasari, Ratih; Kerami, Djati
2016-02-01
Cervical cancer is the most common cancer in women, and ranks seventh of all cancers worldwide, with 529000 cases in 2008 and more than 85% cases occur in developing countries. One way to treat this cancer is through the inhibition of HDAC enzymes which play a strategic role in the regulation of gene expression. Suberoyl Anilide Hydroxamic Acid (SAHA) or Vorinostat is a drug which commercially available to treat the cancer, but still has some side effects. This research present in silico SAHA modification in Zinc Binding Group (ZBG) by organoselenium compound to get ligands which less side effect. From molecular docking simulation, and interaction analysis, there are five best ligands, namely CC27, HA27, HB28, IB25, and KA7. These five ligands have better binding affinity than the standards, and also have interaction with Zn2+ cofactor of inhibited HDAC enzymes. This research is expected to produce more potent HDAC inhibitor as novel drug for cervical cancer treatment.
Kuidas eesti keele õppijad ja kasutajad lause verbi ajavormi sobivust hindavad?
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Diana Maisla
2011-05-01
Full Text Available Verbi ajavormide kasutamine on üks grammatika valdkondadest, mis pakub jätkuvalt huvi teise keele omandamise uurijatele. Artiklis on vaatluse all grammatilise sobivuse hindamise testi tulemused, milles võrreldakse 96 vene ja 100 eesti emakeelega üliõpilase valikuid ülesandes, kus tuli hinnata oleviku ja kolme mineviku ajavormi sobivust eestikeelsesse lausesse skaalal sobib täpselt / sobib samuti / ei sobi. Kogutud andmeid on töödeldud SPSS-programmi abil ning statistiliste testide tulemuste põhjal selgitatud välja erinevused keelejuhtide rühmade vahel. Olulised erinevused kahe rühma vahel ilmnesid täis- ja enneminevikulise verbi sobivusele antud hinnangute vahel, kuid oleviku ja lihtmineviku sobivust on vene keelejuhid hinnanud eesti keelejuhtidega suhteliselt sarnaselt. http://dx.doi.org/10.5128/ERYa7.06
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Doughty Martin L
2011-05-01
Full Text Available Abstract Background Histone deacetylases (HDACs are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neuroprotective effects and stimulate neurogenesis in neuropathological conditions. However, the direct effects of HDACi on cell cycle progression and proliferation, two properties required for continued neurogenesis, have not been fully characterized in adult neural stem cells (NSCs. In this study, we examined the effects of two broad class I and class II HDACi on adult mouse NSCs, the hydroxamate-based HDACi suberoylanilide hydroxamic acid (vorinostat, SAHA and the short chain fatty acid HDACi sodium butyrate. Results We show that both HDACi suppress the formation of neurospheres by adult mouse NSCs grown in proliferation culture conditions in vitro. DNA synthesis is significantly inhibited in adult mouse NSCs exposed to either SAHA or sodium butyrate and inhibition is associated with an arrest in the G1 phase of the cell cycle. HDACi exposure also resulted in transcriptional changes in adult mouse NSCs. Cdk inhibitor genes p21 and p27 transcript levels are increased and associated with elevated H3K9 acetylation levels at proximal promoter regions of p21 and p27. mRNA levels for notch effector Hes genes and Spry-box stem cell transcription factors are downregulated, whereas pro-neural transcription factors Neurog1 and Neurod1 are upregulated. Lastly, we show HDAC inhibition under proliferation culture conditions leads to long-term changes in cell fate in adult mouse NSCs induced to differentiate in vitro. Conclusion SAHA and sodium butyrate directly regulate cdk inhibitor transcription to control cell cycle progression in adult mouse NSCs. HDAC inhibition results in G1 arrest in adult mouse NSCs and transcriptional changes
Antisociální chování dospívajících: výsledky české části mezinárodního projektu SAHA
Czech Academy of Sciences Publication Activity Database
Sobotková, Veronika
2011-01-01
Roč. 8, č. 5 (2011), s. 6-7 ISSN 1214-8717 R&D Project s: GA AV ČR IBS7025354 Institutional research plan: CEZ:AV0Z70250504 Keywords : antisocial behavior * adolescence * SAHA project Subject RIV: AN - Psychology
Balzeau, Antoine
2013-06-01
Homo erectus sensu lato (s.l.) is a key species in the hominin fossil record for the study of human evolution, being one of the first species discovered and perhaps the most documented, but also because of its long temporal range and having dispersed out of Africa earlier than any other human species. Here I test two proposed autapomorphic traits of H. erectus, namely the increased thickness of the upper cranial vault and parasagittal keeling. The definition of these two anatomical features and their expression and variation among hominids are discussed. The results of this study indicate that the upper vault in Asian H. erectus is not absolutely thicker compared with fossil anatomically modern Homo sapiens, whereas Broken Hill and Petralona have values above the range of variation of H. erectus. Moreover, this anatomical region in Asian H. erectus is not significantly thicker compared with Pan paniscus. In addition, these results demonstrate that cranial vault thickness should not be used to make hypotheses regarding sexual attribution of fossil hominin specimens. I also show that the relation between relief on the external surface of the upper vault, parasagittal keeling and bregmatic eminence, and bone thickness is complex. In this context, the autapomorphic status of the two analysed traits in H. erectus may be rejected. Nevertheless, different patterns in the distribution of bone thickness on the upper vault were identified. Some individual variations are visible, but specificities are observable in samples of different species. The pattern of bone thickness distribution observed in Asian H. erectus, P. paniscus, possibly australopiths, and early Homo or Homo ergaster/erectus appears to be shared by these different species and would be a plesiomorphic trait among hominids. In contrast, two apomorphic states for this feature were identified for Neandertals and H. sapiens. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Annekatrin Kaivapalu
2015-04-01
Full Text Available Artiklis käsitletakse kirjaliku eesti ja soome keele vastastikust mõistmist üksiksõna- ja tekstitasandil. Eesmärk on selgitada, kas ja kuidas eesti- ja soomekeelsed keelekasutajad mõistavad oma emakeele põhjal lähedast sugulaskeelt ilma sihtkeele õppimis- ja kasutuskogemuseta ning mille poolest erineb üksiksõnade mõistmine tervikteksti mõistmisest. Mõistmistestide vastuste ja osalejate eneserefleksiooni analüüsi keskmes on kahe sihtkeele mõistmise võimalik sümmeetria ning mõistmisprotsessi mõjutavad tegurid. Tulemuste põhjal osutusid eestikeelsed keelekasutajad edukamaks üksiksõnatestis, eriti eesti ja soome keeles samatähenduslike kirjapildilt sarnaste sõnade ning laen- ja võõrsõnade mõistmisel, soomekeelsed keelekasutajad tervikteksti mõistmisel. Mõlema sihtkeele mõistmisel on otsustav keeltevahelise sarnasuse tunnetamine: toetutakse esmajoones eesti ja soome, aga ka muude varem õpitud keelte ja sihtkeele sarnasusele, seostades seda metalingvistiliste ja üldteadmistega ning kontrollides oletusi lause-, lõigu- ja tekstikontekstis. Kontekst toimib omalaadse filtrina, mis selekteerib keelekasutaja oletusi neid aktsepteerides või tagasi lükates. Mõistmisprotsessi komponentide jaotus ja suund varieeruvad indiviiditi ja sõltuvad paljuski osalejate varasematest teadmistest ja kogemustest.
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Ashagrie Gibtan
2016-12-01
Full Text Available The draft genome sequence of Halorubrum sp. SAH-A6, isolated from commercial rock salts of the Danakil depression, Ethiopia. The genome comprised 3,325,770 bp, with the G + C content of 68.0%. The strain has many genes which are responsible for secondary metabolites biosynthesis, transport and catabolism as compared to other Halorubrum archaea members. Abundant genes responsible for numerous transport systems, solute accumulation, and aromatic/sulfur decomposition were detected. The first genomic analysis encourages further research on comparative genomics, and biotechnological applications. The NCBI accession number for this genome is SAMN04278861 and ID: 4278861 and strain deposited with accession number KCTC 43215.
Osmaston, M. F.
2012-04-01
Introduction. The 'deep-keeled cratons' frame for global dynamics is the result of seeking Earth-behaviour answers to the following outside-the-box proposition:- "If cratons have tectospheric keels that reach or approach the 660 km discontinuity, AND the 660 level is an effective barrier to mantle circulation, then obviously (i) when two cratons separate, the upper mantle to put under the nascent ocean must arrive by a circuitous route and, conversely, (ii) if they approach one another, the mantle volume that was in between them must get extruded sideways." Surprisingly it has turned out [1 - 4] that Earth dynamical behaviour for at least the past 150 Ma provides persuasive affirmation of both these expectations and that there is a rational petrological explanation for the otherwise-unexpected immobility of subcratonic material to such depths [5 - 7]. Clockwise rotation of Antarctica? This contribution greatly amplifies my original plate dynamical arguments for suggesting [8] that such rotation is ongoing. Convection is unsuited to causing rotation about a pole within the plate so, as noted then, a gearwheel-like linkage to Africa at the SWIR would provide its clearly CCW (Biscay-Caucasus) relationship to the Mediterranean belt for the past 100 Ma, also seen in its separation from South America. Gearwheel-like linkage of motion requires the presence of some kind of E-W restraint further north. In that case it was the N Africa/Arabia involvement in the Alpide belt, but the earlier opening of the central Atlantic by the eastward motion of Africa, suggests its rigid Gondwanan attachment to Antarctica rotation at that time, with little constraint in the north. Further east, the seafloor data show that Australia-Antarctica separation involved no such opposite rotational linkage, so, with no E-W mechanical constraint in the north by Indonesia, they must have rotated together, as is recorded by Australia's eastward motion to generate the Mesozoic seafloor at its western
International Nuclear Information System (INIS)
Kerl, Kornelius; Eveslage, Maria; Jung, Manfred; Meisterernst, Michael; Frühwald, Michael; Ries, David; Unland, Rebecca; Borchert, Christiane; Moreno, Natalia; Hasselblatt, Martin; Jürgens, Heribert; Kool, Marcel; Görlich, Dennis
2013-01-01
Rhabdoid tumors are highly aggressive malignancies affecting infants and very young children. In many instances these tumors are resistant to conventional type chemotherapy necessitating alternative approaches. Proliferation assays (MTT), apoptosis (propidium iodide/annexin V) and cell cycle analysis (DAPI), RNA expression microarrays and western blots were used to identify synergism of the HDAC (histone deacetylase) inhibitor SAHA with fenretinide, tamoxifen and doxorubicin in rhabdoidtumor cell lines. HDAC1 and HDAC2 are overexpressed in primary rhabdoid tumors and rhabdoid tumor cell lines. Targeting HDACs in rhabdoid tumors induces cell cycle arrest and apoptosis. On the other hand HDAC inhibition induces deregulated gene programs (MYCC-, RB program and the stem cell program) in rhabdoid tumors. These programs are in general associated with cell cycle progression. Targeting these activated pro-proliferative genes by combined approaches of HDAC-inhibitors plus fenretinide, which inhibits cyclinD1, exhibit strong synergistic effects on induction of apoptosis. Furthermore, HDAC inhibition sensitizes rhabdoid tumor cell lines to cell death induced by chemotherapy. Our data demonstrate that HDAC inhibitor treatment in combination with fenretinide or conventional chemotherapy is a promising tool for the treatment of chemoresistant rhabdoid tumors
Examination of the Validity of the Saha Equation in a Gas Discharge
Energy Technology Data Exchange (ETDEWEB)
Shaw, J. F.; Kruger, C. H.; Mitchner, M.; Viegas, J. R. [Stanford University, CA (United States)
1966-11-15
-Maxwellian distribution function with depleted tail, are considered. Under some conditions, either mechanism may produce a degree of ionization considerably different from that predicted by the Saha equation at the electron temperature. (author)
2005-01-01
Current research in High Energy Physics focuses on a number of enigmatic issues that go beyond the very successful Standard Model of particle physics. Among these are the problem of neutrino mass, the (as yet) unobserved Higgs particle, the quark-gluon plasma, quantum aspects of gravity, and the so--called hierarchy problem. Satisfactory resolution of these important questions will take much research effort in both theory and experiment. The Science & Engineering Research Council, Department of Science & Technology has sponsored a series of SERC Schools in Theoretical High Energy Physics over the past several years, to provide instruction and training to graduate students working for research degrees. This book is an outcome of the schools held at the Saha Institute of Nuclear Physics, Kolkata in 2000, and at the Harish-Chandra Research Institute, Allahabad in 2001. Based on lectures by active researchers in the field---Rajiv Gavai, Debashis Ghoshal, Dileep Jatkar, Anjan Joshipura, Biswarup Mukhopadhy...
Vinnik, L.; Singh, A.; Kiselev, S.; Kumar, M. Ravi
2007-12-01
The fate of the mantle lithosphere of the Indian Plate in the India-Eurasia collision zone is not well understood. Tomographic studies reveal high P velocity in the uppermost mantle to the south of the western Himalaya, and these high velocities are sometimes interpreted as an image of subducting Indian lithosphere. We suggest that these high velocities are unrelated to the ongoing subduction but correspond to a near-horizontal mantle keel of the Indian shield. In the south of the Indian shield upper-mantle velocities are anomalously low, and relatively high velocities may signify a recovery of the normal shield structure in the north. Our analysis is based on the recordings of seismograph station NIL in the foothills of the western Himalaya. The T component of the P receiver functions is weak relative to the Q component, which is indicative of a subhorizontally layered structure. Joint inversion of the P and S receiver functions favours high uppermost mantle velocities, typical of the lithosphere of Archean cratons. The arrival of the Ps converted phase from 410 km discontinuity at NIL is 2.2 s earlier than in IASP91 global model. This can be an effect of remnants of Tethys subduction in the mantle transition zone and of high velocities in the keel of the Indian shield. Joint inversion of SKS particle motions and P receiver functions reveals a change in the fast direction of seismic azimuthal anisotropy from 60° at 80-160 km depths to 150° at 160-220 km. The fast direction in the lower layer is parallel to the trend of the Himalaya. The change of deformation regimes at a depth of 160 km suggests that this is the base of the lithosphere of the Indian shield. A similar boundary was found with similar techniques in central Europe and the Tien Shan region, but the base of the lithosphere in these regions is relatively shallow, in agreement with the higher upper-mantle temperatures. The ongoing continental collision is expressed in crustal structure: the crust
García David, S; Cortijo Martínez, J A; Navarro Bermúdez, I; Maculé, F; Hinarejos, P; Puig-Verdié, L; Monllau, J C; Hernández Hermoso, J A
2014-01-01
The keel design of the tibial tray is essential for the transmission of the majority of the forces to the peripheral bone structures, which have better mechanical proprieties, thus reducing the risk of loosening. The aim of the present study was to compare the behaviour of different tibial tray designs submitted to torsional forces. Four different tibial components were modelled. The 3-D reconstruction was made using the Mimics software. The solid elements were generated by SolidWorks. The finite elements study was done by Unigraphics. A torsional force of 6 Nm. applied to the lateral aspects of each tibial tray was simulated. The GENUTECH® tibial tray, with peripheral trabecular bone support, showed a lower displacement and less transmitted tensions under torsional forces. The results suggest that a tibial tray with more peripheral support behaves mechanically better than the other studied designs. Copyright © 2013 SECOT. Published by Elsevier Espana. All rights reserved.
Toscano, M J; Booth, F; Wilkins, L J; Avery, N C; Brown, S B; Richards, G; Tarlton, J F
2015-05-01
Keel fractures in the laying hen are the most critical animal welfare issue facing the egg production industry, particularly with the increased use of extensive systems in response to the 2012 EU directive banning conventional battery cages. The current study is aimed at assessing the effects of 2 omega-3 (n3) enhanced diets on bone health, production endpoints, and behavior in free-range laying hens. Data was collected from 2 experiments over 2 laying cycles, each of which compared a (n3) supplemented diet with a control diet. Experiment 1 employed a diet supplemented with a 60:40 fish oil-linseed mixture (n3:n6 to 1.35) compared with a control diet (n3:n6 to 0.11), whereas the n3 diet in Experiment 2 was supplemented with a 40:60 fish oil-linseed (n3:n6 to 0.77) compared to the control diet (n3:n6 to 0.11). The n3 enhanced diet of Experiment 1 had a higher n3:n6 ratio, and a greater proportion of n3 in the long chain (C20/22) form (0.41 LC:SC) than that of Experiment 2 (0.12 LC:SC). Although dietary treatment was successful in reducing the frequency of fractures by approximately 27% in Experiment 2, data from Experiment 1 indicated the diet actually induced a greater likelihood of fracture (odds ratio: 1.2) and had substantial production detriment. Reduced keel breakage during Experiment 2 could be related to changes in bone health as n3-supplemented birds demonstrated greater load at failure of the keel, and tibiae and humeri that were more flexible. These results support previous findings that n3-supplemented diets can reduce fracture likely by increasing bone strength, and that this can be achieved without detriment to production. However, our findings suggest diets with excessive quantities of n3, or very high levels of C20/22, may experience health and production detriments. Further research is needed to optimize the quantity and type of n3 in terms of bone health and production variables and investigate the potential associated mechanisms. © 2015
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Christopher E. Pelt
2014-01-01
Full Text Available Little data exists regarding outcomes following TKA performed with surface-cementation for the fixation of modular tibial baseplates with press-fit keels. Thus, we retrospectively reviewed the clinical and radiographic outcomes of 439 consecutive primary TKAs performed with surface cemented tibial components. There were 290 female patients and 149 male patients with average age of 62 years (range 30–84. Two tibial components were revised for aseptic loosening (0.5% and four tibial components (0.9% were removed to improve instability (n=2 or malalignment (n=2. Complications included 13 deep infections treated with 2-stage revision (12 and fusion (1. These results support the surface cement technique with a modular grit-blasted titanium surface and cruciform stem during primary TKA.
Le Vien, Nguyen Thi; Nguyen, Pham Bao; Cuong, Lam Duc; An, Trinh Thi Thua; Dao, Dong Thi Anh
2017-09-01
Glycosaminoglycans (GAGs) are natural biocompounds which join to construct cartilage tissuses, it can be extracted from cartilage of sharks, pigs, cows, chickens, etc. GAGs contain a Chondroitin sulfate (CS) content which is a supplement of functional food used for preventing and supporting treatment of arthritis and eye diseases. Therefore, the GAGs extraction from byproducts of the industry of cattle and poultry slaughter to identify the CS content by papain enzyme is necessary. In this study, the optimal hydrolysis conditions were obtained by response surface methodology (RSM). The independent variables were coded as: pH (x1), enzyme concentration (x2), incubation temperature (x3) and hydrolysis time (x4). The results of the analysis of variance (ANOVA) shown that the variables actively affected GAGs content. The optimal conditions of hydrolysis were derived at pH of 7.1, ratio of enzyme per substances of 0.62% w/wpo, temperature of 65°C and hydrolysis time of 230 minutes, GAGs content reached 14.3% of the dry matter of raw material. Analyzes by HPLC revealed that 56.17% of the dry preparations of GAGs were CS compound, were equivalent to 8.11% of the dry matter of chicken keel cartilage. Molecular weight of the dry preparations GAGs was 259.6 kDa. The dry preparations included the contents of moisture 12.2%, protein 8.42%, lipid 0%, ash 10.03% and extracted GAGs 69.35%.
International Nuclear Information System (INIS)
Chien, Chia-Wen; Yao, Ju-Hsien; Chang, Shih-Yu; Lee, Pei-Chih; Lee, Te-Chang
2011-01-01
The efficacy of arsenic trioxide (ATO) against acute promyelocytic leukemia (APL) and relapsed APL has been well documented. ATO may cause DNA damage by generating reactive oxygen intermediates. Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, modulates gene and protein expression via histone-dependent or -independent pathways that may result in chromatin decondensation, cell cycle arrest, differentiation, and apoptosis. We investigated whether ATO and SAHA act synergistically to enhance the death of cancer cells. Our current findings showed that combined treatment with ATO and SAHA resulted in enhanced suppression of non-small-cell lung carcinoma in vitro in H1299 cells and in vivo in a xenograft mouse model. Flow cytometric analysis of annexin V+ cells showed that apoptotic cell death was significantly enhanced after combined treatment with ATO and SAHA. At the doses used, ATO did not interfere with cell cycle progression, but SAHA induced p21 expression and led to G1 arrest. A Comet assay demonstrated that ATO, but not SAHA, induced DNA strand breaks in H1299 cells; however, co-treatment with SAHA significantly increased ATO-induced DNA damage. Moreover, SAHA enhanced acetylation of histone H3 and sensitized genomic DNA to DNase I digestion. Our results suggest that SAHA may cause chromatin relaxation and increase cellular susceptibility to ATO-induced DNA damage. Combined administration of SAHA and ATO may be an effective approach to the treatment of lung cancer. -- Highlights: ► ATO and SAHA are therapeutic agents with different action modes. ► Combination of ATO and SAHA synergistically inhibits tumor cell growth. ► SAHA loosens chromatin structure resulting in increased sensitivity to DNase I. ► ATO-induced DNA damage and apoptosis are enhanced by co-treatment with SAHA.
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Ariungerel Gerelchuluun
2018-02-01
Full Text Available Suberoylanilide hydroxamic acid (SAHA is a histone deacetylase inhibitor, which has been widely utilized throughout the cancer research field. SAHA-induced radiosensitization in normal human fibroblasts AG1522 and lung carcinoma cells A549 were evaluated with a combination of γ-rays, proton, and carbon ion exposure. Growth delay was observed in both cell lines during SAHA treatment; 2 μM SAHA treatment decreased clonogenicity and induced cell cycle block in G1 phase but 0.2 μM SAHA treatment did not show either of them. Low LET (Linear Energy Transfer irradiated A549 cells showed radiosensitization effects on cell killing in cycling and G1 phase with 0.2 or 2 μM SAHA pretreatment. In contrast, minimal sensitization was observed in normal human cells after low and high LET radiation exposure. The potentially lethal damage repair was not affected by SAHA treatment. SAHA treatment reduced the rate of γ-H2AX foci disappearance and suppressed RAD51 and RPA (Replication Protein A focus formation. Suppression of DNA double strand break repair by SAHA did not result in the differences of SAHA-induced radiosensitization between human cancer cells and normal cells. In conclusion, our results suggest SAHA treatment will sensitize cancer cells to low and high LET radiation with minimum effects to normal cells.
Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line
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Nainong Li
2015-05-01
Full Text Available Objective. This study aimed to investigate the chemosensitive augmentation effect and mechanism of HDAC inhibitor Vorinostat (SAHA in combination with arsenic trioxide (ATO on proliferation and apoptosis of K562 cells.Methods. The CCK-8 assay was used to compare proliferation of the cells. Annexin-V and PI staining by flow cytometry and acridine orange/ethidium bromide stains were used to detect and quantify apoptosis. Western blot was used to detect expression of p21, Akt, pAkt, p210, Acetyl-Histone H3, and Acetyl-Histone H4 proteins.Results. SAHA and ATO inhibited proliferation of K562 cells in an additive and time- and dose-dependent manner. SAHA in combination with ATO showed significant apoptosis of K562 cells in comparison to the single drugs alone (p < 0.01. Both SAHA and ATO alone and in combination showed lower levels of p210 expression. SAHA and SAHA and ATO combined treatment showed increased levels of Acetyl-Histone H3 and Acetyl-Histone H4 protein expression. SAHA alone showed increased expression of p21, while ATO alone and in combination with SAHA showed no significant change. SAHA and ATO combined therapy showed lower levels of Akt and pAkt protein expression than SAHA or ATO alone.Conclusion. SAHA and ATO combined treatment inhibited proliferation, induced apoptosis, and showed a chemosensitive augmentation effect on K562 cells. The mechanism might be associated with increasing histone acetylation levels as well as regulating the Akt signaling pathway.
You, Bo Ra; Han, Bo Ram; Park, Woo Hyun
2017-03-14
Suberoylanilide hydroxamic acid (SAHA) as a histone deacetylase (HDAC) inhibitor has anti-cancer effect. Here, we evaluated the effect of SAHA on HDAC activity and cell growth in many normal lung and cancer cells. We observed that the HDAC activities of lung cancer cells were higher than that of normal lung cells. SAHA inhibited the growth of lung cancer cells regardless of the inhibitory effect on HDAC. This agent induced a G2/M phase arrest and apoptosis, which was accompanied by mitochondrial membrane potential (MMP: ΔΨm) loss in lung cancer cells. However, SAHA did not induce cell death in normal lung cells. All tested caspase inhibitors prevented apoptotic cell death in SAHA-treated A549 and Calu-6 lung cancer cells. Treatment with tumor necrosis factor-alpha (TNF-α) enhanced apoptosis in SAHA-treated lung cancer cells through caspase-8 and caspase-9 activations. Especially, SAHA increased the expression level of TNF-α receptor 1 (TNFR1), especially acetylation of the region of TNFR1 promoter -223/-29 in lung cancer cells. The down-regulation of TNFR1 suppressed apoptosis in TNF-α and SAHA-treated lung cancer cells. In conclusion, SAHA inhibited the growth of lung cancer cells via a G2/M phase arrest and caspase-dependent apoptosis. SAHA also enhanced apoptotic effect of TNF-α in human lung cancer cells through up-regulation of TNFR1. TNF-α may be a key to improve anti-cancer effect of HDAC inhibitors.
Dumitriţa Dumitriu, Simina; Dubicka, Zofia; Ionesi, Viorel
2018-01-01
The paper presents Miocene (lower Sarmatian) benthic foraminifera from the FH3P1 Rădăuţi Core section from the northwestern part of the Moldavian Platform, Romania. Based on foraminiferal assemblages we infer sediments were deposited in shallow-water, including marine-marginal environments, of varying salinities from brackish to normal marine with some short and rather small sea-level changes. Moreover, we describe for the first time in the Moldavian Platform a very rare species, Miliolina cristata Millett, which presents a characteristic spinose keel. Based on a detailed study of the test morphology and its variability, observed in picked material as well as in thin sections, we discuss some palaeoecological aspects of these foraminifera. M. cristata probably does not constitute a distinctive species, but it is more probable that some miliolid taxa developed such an exoskeletal feature in response to new environmental conditions, such as more turbulent water. Accordingly, our study would support the thesis that one of the functions of the benthic foraminiferal spines is to stabilize foraminiferal tests found in sandy substrates from high-energy environments.
Lueker, T.; Chinn, P. W. U.
2014-12-01
In May 2013, The, record of atmospheric CO2 at Mauna Loa, popularly known as "The Keeling Curve" reached 400 ppm for the first time in human history. Among the most sobering consequences of rising CO2 is Ocean Acidification, caused when the excess CO2 emitted from the burning of fossil fuels is absorbed by the surface oceans. The resulting reduction in pH harms stony corals (Scleractinia), and many other calcareous organisms. If civilization continues along the current trajectory of fossil fuel emissions, most coral reef ecosystems are expected to suffer extreme stress or mortality within the lifetime of the next generation. "If we do not reverse current trends in carbon dioxide emissions soon, we will cause the biggest and most rapid change in ocean chemistry since the extinction of the dinosaurs." (www.seaweb.org/getinvolved/oceanvoices/KenCaldeira.php). This looming tragedy is topical among marine scientists, but less appreciated or unknown to the general public, particularly among communities in the tropics where impacts to coral reef ecosystems will be severe. The Coral Reef Mosaic Project grew from my experiences leading education outreach in local schools. Making mosaics is an engaging way to enlighten educators and scholars on the pressing issues of climate change. When taking part in a mural project, students find mosaic art is a fun and rewarding experience that results in a beautiful depiction of a coral reef. Students explore the ecosystem diversity of coral reef inhabitants as they design the mural and piece together a representative environment. They work together as a team to learn the mosaic techniques and then build their own chosen creatures to inhabit the reef. The result is a beautiful and lasting mural for their school or community that provides an important message for the future. In a cooperative project with Dr. Pauline Chin at UH Manoa we traveled to Hawaii to train teachers on the Big Island in the art of mosaic and to convey the
Meylan, Elsa M.; Halfon, Olivier; Magistretti, Pierre J.; Cardinaux, Jean-René
2016-01-01
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better understanding of the neurobiology of depression and the mechanisms underlying antidepressant response is thus critically needed. We previously reported that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) exhibit a depressive-like phenotype and a blunted antidepressant response to the selective serotonin reuptake inhibitor fluoxetine. In this study, we similarly show that Crtc1‒/‒ mice are resistant to the antidepressant effect of chronic desipramine in a behavioral despair paradigm. Supporting the blunted response to this tricyclic antidepressant, we found that desipramine does not significantly increase the expression of Bdnf and Nr4a1-3 in the hippocampus and prefrontal cortex of Crtc1‒/‒ mice. Epigenetic regulation of neuroplasticity gene expression has been associated with depression and antidepressant response, and histone deacetylase (HDAC) inhibitors have been shown to have antidepressant-like properties. Here, we show that unlike conventional antidepressants, chronic systemic administration of the HDAC inhibitor SAHA partially rescues the depressive-like behavior of Crtc1‒/‒ mice. This behavioral effect is accompanied by an increased expression of Bdnf, but not Nr4a1-3, in the prefrontal cortex of these mice, suggesting that this epigenetic intervention restores the expression of a subset of genes by acting downstream of CRTC1. These findings suggest that CRTC1 alterations may be associated with treatment-resistant depression, and support the interesting possibility that targeting HDACs may be a useful therapeutic strategy in antidepressant development.
Meylan, Elsa M.
2016-03-09
Major depression is a highly complex disabling psychiatric disorder affecting millions of people worldwide. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these medications. A better understanding of the neurobiology of depression and the mechanisms underlying antidepressant response is thus critically needed. We previously reported that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) exhibit a depressive-like phenotype and a blunted antidepressant response to the selective serotonin reuptake inhibitor fluoxetine. In this study, we similarly show that Crtc1‒/‒ mice are resistant to the antidepressant effect of chronic desipramine in a behavioral despair paradigm. Supporting the blunted response to this tricyclic antidepressant, we found that desipramine does not significantly increase the expression of Bdnf and Nr4a1-3 in the hippocampus and prefrontal cortex of Crtc1‒/‒ mice. Epigenetic regulation of neuroplasticity gene expression has been associated with depression and antidepressant response, and histone deacetylase (HDAC) inhibitors have been shown to have antidepressant-like properties. Here, we show that unlike conventional antidepressants, chronic systemic administration of the HDAC inhibitor SAHA partially rescues the depressive-like behavior of Crtc1‒/‒ mice. This behavioral effect is accompanied by an increased expression of Bdnf, but not Nr4a1-3, in the prefrontal cortex of these mice, suggesting that this epigenetic intervention restores the expression of a subset of genes by acting downstream of CRTC1. These findings suggest that CRTC1 alterations may be associated with treatment-resistant depression, and support the interesting possibility that targeting HDACs may be a useful therapeutic strategy in antidepressant development.
Kes teevad ülikooli keelekeskuse rahvusvaheliseks? Saage tuttavaks!
2006-01-01
Küsimustele "Mida Eestis oma keelt õpetades raskeimaks peate?" ja "Mis teid Eestis kõige rohkem üllatas?" vastavad Tartu Ülikooli keelekeskuse läti keele lektor Ilze Zagorska, itaalia keele lektor Federica Bossi, prantsuse keele lektor Charlène Manil, korea keele lektor Jinseok Seo, jaapani keele lektor Eri Miyano, ukraina keele lektor Ljudmilla Dulitšenko, hispaania keele lektor Manuel Neftalí Peral Joris, inglise keele lektor Casey Collins ja türgi keele lektor Hagani Gayibli
International Nuclear Information System (INIS)
Thiemann, Markus; Kulozik, Andreas E; Debus, Jürgen; Huber, Peter E; Battmann, Claudia; Oertel, Susanne; Ehemann, Volker; Weichert, Wilko; Stenzinger, Albrecht; Bischof, Marc; Weber, Klaus-J; Perez, Ramon Lopez; Haberkorn, Uwe
2012-01-01
Histone deacetylase inhibitors are promising new substances in cancer therapy and have also been shown to sensitize different tumor cells to irradiation (XRT). We explored the effect as well as the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) in vivo in a malignant rhabdoid tumor (MRT) mouse model. Potential radiosensitization by SAHA was assessed in MRT xenografts by analysis of tumor growth delay, necrosis (HE), apoptosis (TUNEL), proliferation (ki-67) and γH2AX expression as well as dynamic 18 F-Fluorodeoxyglucose Positron Emission Tomography ( 18 F-FDG -PET) after treatment with either SAHA alone, single-dose (10 Gy) or fractionated XRT (3 × 3Gy) solely as well as in combination with SAHA compared to controls. SAHA only had no significant effect on tumor growth. Combination of SAHA for 8 days with single-dose XRT resulted in a higher number of complete remissions, but failed to prove a significant growth delay compared to XRT only. In contrast fractionated XRT plus SAHA for 3 weeks did induce significant tumor growth delay in MRT-xenografts. The histological examination showed a significant effect of XRT in tumor necrosis, expression of Ki-67, γH2AX and apoptosis. SAHA only had no significant effect in the histological examination. Comparison of xenografts treated with XRT and XRT plus SAHA revealed a significantly increased γH2AX expression and apoptosis induction in the mice tumors after combination treatment with single-dose as well as fractionated XRT. The combination of SAHA with XRT showed a tendency to increased necrosis and decrease of proliferation compared to XRT only, which, however, was not significant. The 18 F-FDG-PET results showed no significant differences in the standard uptake value or glucose transport kinetics after either treatment. SAHA did not have a significant effect alone, but proved to enhance the effect of XRT in our MRT in vivo model
Directory of Open Access Journals (Sweden)
Yun-feng Qi
2014-01-01
Full Text Available SAHA (suberoylanilide hydroxamic acid or vorinostat is the first nonselective histone deacetylase (HDAC inhibitor approved by the US Food and Drug Administration (FDA. SAHA affects histone acetylation in chromatin and a variety of nonhistone substrates, thus influencing many cellular processes. In particularly, SAHA induces selective apoptosis of tumor cells, although the mechanism is not well understood. A series of microarray experiments was recently conducted to investigate tumor cell-selective proapoptotic transcriptional responses induced by SAHA. Based on that gene expression time series, we propose a novel framework for detailed analysis of the mechanism of tumor cell apoptosis selectively induced by SAHA. Our analyses indicated that SAHA selectively disrupted the DNA damage response, cell cycle, p53 expression, and mitochondrial integrity of tumor samples to induce selective tumor cell apoptosis. Our results suggest a possible regulation network. Our research extends the existing research.
Directory of Open Access Journals (Sweden)
Han LQ
2016-11-01
Full Text Available Leiqiang Han, Tianqi Wang, Jingliang Wu, Xiaolan Yin, Hao Fang, Na Zhang School of Pharmaceutical Science, Shandong University, Ji’nan, Shandong, People’s Republic of China Abstract: Small molecule-based nanodrugs with nanoparticles (NPs that are mainly composed of small molecules, have been considered as a promising candidate for a next-generation nanodrug, owing to their unique properties. Vorinostat (SAHA is a canonical US Food and Drug Administration-approved histone deacetylase (HDAC inhibitor for the treatment of cutaneous T-cell lymphoma. However, the lack of efficacy against solid tumors hinders its progress in clinical use. Herein, a novel nanodrug of SAHA was developed based on disulfide-linked prodrug SAHA-S-S-VE. SAHA-S-S-VE could self-assemble into 148 nm NPs by disulfide-induced mechanisms, which were validated by molecular dynamics simulations. Under reduced conditions, the redox-responsive behavior of SAHA-S-S-VE was investigated, and the HDAC inhibition results verified the efficient release of free SAHA. With a biocompatible d-a-tocopheryl polyethylene glycol succinate (TPGS functionalization, the SAHA-S-S-VE/TPGS NPs exhibited low critical aggregation concentration of 4.5 µM and outstanding stability in vitro with drug-loading capacity of 24%. In vitro biological assessment indicated that SAHA-S-S-VE/TPGS NPs had significant anticancer activity against HepG2. Further in vivo evaluation demonstrated that the resulting NPs could be accumulated in the tumor region and inhibit the tumor growth effectively. This approach, which turned SAHA into a self-assembled redox-responsive nanodrug, provided a new channel for the use of HDAC inhibitor in solid tumor therapy. Keywords: SAHA, HDAC, small molecule, nanoparticles, self-assemble, disulfide bond
Indian Academy of Sciences (India)
Carroll Alan, Brookhaven National Laboratory, Upton, NY 11973-5000, USA acarroll@bnl.gov. Chakrabarti Dipankar, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064,. India dipankar@theory.saha.ernet.in. Chakraborty Purnendu, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 ...
2013-10-31
..., Saha Thai Steel Pipe (Public) Company, Ltd. (Saha Thai), and Pacific Pipe Company Limited (Pacific Pipe... Pipe (Public) Company, Ltd 0.00 Pacific Pipe Company Limited * * No shipments or sales subject to this... parties to comment on the Preliminary Results. Saha Thai, Wheatland Tube Company, and United States Steel...
International Nuclear Information System (INIS)
Xu, Xing-dong; Yang, Lan; Zheng, Li-yun; Pan, Yan-yan; Cao, Zhi-fei; Zhang, Zhi-qing; Zhou, Quan-sheng; Yang, Bo; Cao, Cong
2014-01-01
Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent. PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed. Associated signaling changes were also analyzed by RT-PCR and Western blots. Here, we reported that SAHA, a histone deacetylase inhibitor (HDACi), exerted significant inhibitory efficiency against pancreatic cancer cell survival, proliferation, migration and VM. SAHA dose-dependently inhibited PaTu8988 pancreatic cancer cell growth with the IC-50 of 3.4 ± 0. 7 μM. Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/cyclin-B1 degradation and p21/p27 upregulation. Further, SAHA induced both apoptotic and non-apoptotic death of PaTu8988 cells. Significantly, SAHA suppressed PaTu8988 cell in vitro migration and cell-dominant tube formation or VM, which was accompanied by semaphorin-4D (Sema-4D) and integrin-β5 down-regulation. Our evidences showed that Akt activation might be important for Sema-4D expression in PaTu8988 cells, and SAHA-induced Sema-4D down-regulation might be associated with Akt inhibition. This study is among the first to report the VM formation in cultured human pancreatic cancer cells. And we provided strong evidence to suggest that SAHA executes significant anti-VM efficiency in the progressive pancreatic cancer cells. Thus, SAHA could be further investigated as a promising anti-pancreatic cancer agent
Yu, J; Wu, H; Lin, Z; Su, K; Zhang, J; Sun, F; Wang, X; Wen, C; Cao, H; Hu, L
2017-12-01
Suberoylanilide hydroxamic acid (SAHA) exerts marked anticancer effects via promotion of apoptosis, cell cycle arrest, and prevention of oncogene expression. In this study, serum metabolomics and artificial intelligence recognition were used to investigate SAHA toxicity. Forty rats (220 ± 20 g) were randomly divided into control and three SAHA groups (low, medium, and high); the experimental groups were treated with 12.3, 24.5, or 49.0 mg kg -1 SAHA once a day via intragastric administration. After 7 days, blood samples from the four groups were collected and analyzed by gas chromatography-mass spectrometry, and pathological changes in the liver were examined using microscopy. The results showed that increased levels of urea, oleic acid, and glutaconic acid were the most significant indicators of toxicity. Octadecanoic acid, pentadecanoic acid, glycerol, propanoic acid, and uric acid levels were lower in the high SAHA group. Microscopic observation revealed no obvious damage to the liver. Based on these data, a support vector machine (SVM) discrimination model was established that recognized the metabolic changes in the three SAHA groups and the control group with 100% accuracy. In conclusion, the main toxicity caused by SAHA was due to excessive metabolism of saturated fatty acids, which could be recognized by an SVM model.
Modulation of radiation response by histone deacetylase inhibition
International Nuclear Information System (INIS)
Chinnaiyan, Prakash; Vallabhaneni, Geetha; Armstrong, Eric M.S.; Huang, Shyh-Min; Harari, Paul M.
2005-01-01
Purpose: Histone deacetylase (HDAC) inhibitors, which modulate chromatin structure and gene expression, represent a class of anticancer agents that hold particular potential as radiation sensitizers. In this study, we examine the capacity of the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) to modulate radiation response in human tumor cell lines and explore potential mechanisms underlying these interactions. Methods and materials: Cell proliferation: Exponentially growing tumor cells were incubated in medium containing 0-10 μM of SAHA for 72 h. Cells were fixed/stained with crystal violet to estimate cell viability. Apoptosis: Caspase activity was analyzed by fluorescence spectroscopy using a fluorescein labeled pan-caspase inhibitor. Cells were harvested after 48 h of exposure to SAHA (1.0 μM), radiation (6 Gy), or the combination. Whole cell lysates were evaluated for poly(ADP-ribose) polymerase (PARP) cleavage by western blot analysis. Radiation survival: Cells were exposed to varying doses of radiation ± 3 days pretreatment with SAHA (0.75-1.0 μM). After incubation intervals of 14-21 days, colonies were stained with crystal violet and manually counted. Immunocytochemistry: Cells were grown and treated in chamber slides. At specified times after treatment with SAHA, cells were fixed in paraformaldehyde, permeabilized in methanol, and probed with primary and secondary antibody solutions. Slides were analyzed using an epifluorescent microscope. Results: SAHA induced a dose-dependent inhibition of proliferation in human prostate (DU145) and glioma (U373vIII) cancer cell lines. Exposure to SAHA enhanced radiation-induced apoptosis as measured by caspase activity (p < 0.05) and PARP cleavage. The impact of SAHA on radiation response was further characterized using clonogenic survival analysis, which demonstrated that treatment with SAHA reduced tumor survival after radiation exposure. We identified several oncoproteins and DNA damage repair proteins
International Nuclear Information System (INIS)
Pal, Rabindranath; Biswas, Subir; Basu, Subhasis; Chattopadhyay, Monobir; Basu, Debjyoti; Chaudhuri, Manis
2010-01-01
The Magnetized Plasma Linear Experimental (MaPLE) device is a low cost laboratory plasma device at Saha Institute of Nuclear Physics fabricated in-house with the primary aim of studying basic plasma physics phenomena such as plasma instabilities, wave propagation, and their nonlinear behavior in magnetized plasma regime in a controlled manner. The machine is specially designed to be a versatile laboratory device that can provide a number of magnetic and electric scenario to facilitate such studies. A total of 36 number of 20-turn magnet coils, designed such as to allow easy handling, is capable of producing a uniform, dc magnetic field of about 0.35 T inside the plasma chamber of diameter 0.30 m. Support structure of the coils is planned in an innovative way facilitating straightforward fabrication and easy positioning of the coils. Further special feature lies in the arrangement of the spacers between the coils that can be maneuvered rather easily to create different magnetic configurations. Various methods of plasma production can be suitably utilized according to the experimental needs at either end of the vacuum vessel. In the present paper, characteristics of a steady state plasma generated by electron cyclotron resonance method using 2.45 GHz microwave power are presented. Scans using simple probe drives revealed that a uniform and long plasma column having electron density ∼ 3–5×1010 cm−3 and temperature ∼ 7–10 eV, is formed in the center of the plasma chamber which is suitable for wave launching experiments.
International Nuclear Information System (INIS)
Blattmann, C.; Oertel, S.; Thiemann, M.; Weber, K.J.; Schmezer, P.; Zelezny, O.; Lopez Perez, R.; Kulozik, A.E.; Debus, J.; Ehemann, V.
2012-01-01
Osteosarcoma and atypical teratoid rhabdoid tumors are tumor entities with varying response to common standard therapy protocols. Histone acetylation affects chromatin structure and gene expression which are considered to influence radiation sensitivity. The aim of this study was to investigate the effect of the combination therapy with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) and irradiation on atypical teratoid rhabdoid tumors and osteosarcoma compared to normal tissue cell lines. Clonogenic assay was used to determine cell survival. DNA double-strand breaks (DSB) were examined by pulsed-field electrophoresis (PFGE) as well as by γH2AX immunostaining involving flow cytometry, fluorescence microscopy, and immunoblot analysis. SAHA lead to an increased radiosensitivity in tumor but not in normal tissue cell lines. γH2AX expression as an indicator for DSB was significantly increased when SAHA was applied 24 h before irradiation to the sarcoma cell cultures. In contrast, γH2AX expression in the normal tissue cell lines was significantly reduced when irradiation was combined with SAHA. Analysis of initial DNA fragmentation and fragment rejoining by PFGE, however, did not reveal differences in response to the SAHA pretreatment for either cell type. SAHA increases radiosensitivity in tumor but not normal tissue cell lines. The increased H2AX phosphorylation status of the SAHA-treated tumor cells post irradiation likely reflects its delayed dephosphorylation within the DNA damage signal decay rather than chromatin acetylation-dependent differences in the overall efficacy of DSB induction and rejoining. The results support the hypothesis that combining SAHA with irradiation may provide a promising strategy in the treatment of solid tumors. (orig.)
International Nuclear Information System (INIS)
Singh, Sheetal; Le Hongan; Shih, S.-J.; Ho, Bay; Vaughan, Andrew T.
2010-01-01
Purpose: Chromatin-modifying compounds that inhibit the activity of histone deacetylases have shown potency as radiosensitizers, but the action of these drugs at a molecular level is not clear. Here we investigated the effect of suberoylanilide hydroxyamic acid (SAHA) on DNA breaks and their repair and induction of rearrangements. Methods and Materials: The effect of SAHA on both clonogenic survival and repair was assessed using cell lines SCC-25, MCF7, and TK6. In order to study unique DNA double-strand breaks, anti-CD95 antibody was employed to introduce a DNA double-strand break at a known location within the 11q23 region. The effects of SAHA on DNA cleavage and rearrangements were analyzed by ligation-mediated PCR and inverse PCR, respectively. Results: SAHA acts as radiosensitizer at 1 μM, with dose enhancement factors (DEFs) at 10% survival of: SCC-25 - 1.24 ± 0.05; MCF7 - 1.16 ± 0.09 and TK6 - 1.17 ± 0.05, and it reduced the capacity of SCC-25 cells to repair radiation induced lesions. Additionally, SAHA treatment diffused site-specific fragmentation over at least 1 kbp in TK6 cells. Chromosomal rearrangements produced in TK6 cells exposed to SAHA showed a reduction in microhomology at the breakpoint between 11q23 and partner chromosomes. Conclusions: SAHA shows efficacy as a radiosensitizer at clinically obtainable levels. In its presence, targeted DNA strand breaks occur over an expanded region, indicating increased chromatin access. The rejoining of such breaks is degraded by SAHA when measured as rearrangements at the molecular level and rejoining that contributes to cell survival.
Dudakovic, Amel; Evans, Jared M.; Li, Ying; Middha, Sumit; McGee-Lawrence, Meghan E.; van Wijnen, Andre J.; Westendorf, Jennifer J.
2013-01-01
Bone has remarkable regenerative capacity, but this ability diminishes during aging. Histone deacetylase inhibitors (HDIs) promote terminal osteoblast differentiation and extracellular matrix production in culture. The epigenetic events altered by HDIs in osteoblasts may hold clues for the development of new anabolic treatments for osteoporosis and other conditions of low bone mass. To assess how HDIs affect the epigenome of committed osteoblasts, MC3T3 cells were treated with suberoylanilide hydroxamic acid (SAHA) and subjected to microarray gene expression profiling and high-throughput ChIP-Seq analysis. As expected, SAHA induced differentiation and matrix calcification of osteoblasts in vitro. ChIP-Seq analysis revealed that SAHA increased histone H4 acetylation genome-wide and in differentially regulated genes, except for the 500 bp upstream of transcriptional start sites. Pathway analysis indicated that SAHA increased the expression of insulin signaling modulators, including Slc9a3r1. SAHA decreased phosphorylation of insulin receptor β, Akt, and the Akt substrate FoxO1, resulting in FoxO1 stabilization. Thus, SAHA induces genome-wide H4 acetylation and modulates the insulin/Akt/FoxO1 signaling axis, whereas it promotes terminal osteoblast differentiation in vitro. PMID:23940046
Directory of Open Access Journals (Sweden)
Martin Rao
2018-04-01
Full Text Available Background: New tuberculosis (TB drug treatment regimens are urgently needed. This study evaluated the potential of the histone deacetylase inhibitors (HDIs valproic acid (VPA and suberoylanilide hydroxamic acid (SAHA to enhance the effects of first-line anti-TB drugs against intracellular Mycobacterium tuberculosis. Methods: M. tuberculosis H37Rv cultures were exposed to VPA or SAHA over 6 days, in the presence or absence of isoniazid (INH and rifampicin (RIF. The efficacy of VPA and SAHA against intracellular M. tuberculosis with and without INH or RIF was tested by treating infected macrophages. Bactericidal activity was assessed by counting mycobacterial colony-forming units (CFU. Results: VPA treatment exhibited superior bactericidal activity to SAHA (2-log CFU reduction, while both HDIs moderately improved the activity of RIF against extracellular M. tuberculosis. The bactericidal effect of VPA against intracellular M. tuberculosis was greater than that of SAHA (1-log CFU reduction and equalled that of INH (1.5-log CFU reduction. INH/RIF and VPA/SAHA combination treatment inhibited intracellular M. tuberculosis survival in a shorter time span than monotherapy (3 days vs. 6 days. Conclusions: VPA and SAHA have adjunctive potential to World Health Organization-recommended TB treatment regimens. Clinical evaluation of the two drugs with regard to reducing the treatment duration and improving treatment outcomes in TB is warranted. Keywords: Mycobacterium tuberculosis, Adjunct host-directed therapy, Tuberculosis, Histone deacetylase inhibitors, Repurposed drugs
Anumanthan, Govindaraj; Sharma, Ajay; Waggoner, Michael; Hamm, Chuck W; Gupta, Suneel; Hesemann, Nathan P; Mohan, Rajiv R
2017-12-01
This study compared the efficacy and safety of suberoylanilide hydroxamic acid (SAHA) and mitomycin C (MMC) up to 4 months in the prevention of corneal haze induced by photorefractive keratectomy (PRK) in rabbits in vivo. Corneal haze in rabbits was produced with -9.00 diopter PRK. A single application of SAHA (25 μM) or MMC (0.02%) was applied topically immediately after PRK. Effects of the two drugs were analyzed by slit-lamp microscope, specular microscope, TUNEL assay, and immunofluorescence. Single topical adjunct use of SAHA (25 μM) or MMC (0.02%) after PRK attenuated more than 95% corneal haze and myofibroblast formation (P PRK in rabbits in vivo. SAHA exhibited significantly reduced short- and long-term damage to the corneal endothelium compared to MMC in rabbits. SAHA is an effective and potentially safer alternative to MMC for the prevention of corneal haze after PRK. Clinical trials are warranted. [J Refract Surg. 2017;33(12):834-839.]. Copyright 2017, SLACK Incorporated.
Vadja sõnaraamat kui kunstiteos / Kristiina Ross
Ross, Kristiina, 1955-
2011-01-01
Arvustus: Vadja keele sõnaraamat. 1 / toimetanud Elna Adler, Merle Leppik. Tallinn : AE Signalet, 1990 ; Vadja keele sõnaraamat. 2, [K -küüttöseltšä] = Словарь водского языка. 2 / toimetanud Elna Adler, Merle Leppik. [Tallinn] ; [Tallinn] : Teaduste Akadeemia Kirjastus, 1994 ; Vadja keele sõnaraamat. 3, L - müüäG] = Словарь водского языка / toimetanud Elna Adler, Merle Leppik. [Tallinn] ; [Tallinn] : Eesti Keele Instituut, 1996 ; Vadja keele sõnaraamat. 4, [N - P] = Словарь водского языка. 4, [N - P] / toimetanud: Elna Adler, Merle Leppik. [Tallinn] : Eesti Keele Sihtasutus, 2000 ; Vadja keele sõnaraamat. 5, [R-S] = Словарь водского языка. 5, [R-S] / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2006 ; Vadja keele sõnaraamat. 6, [Š-T] = Словарь водского языка. 6, [Š-T] / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2010 ; Vadja keele sõnaraamat. 7 = Словарь водского языка / toimetanud Silja Grünberg. Tallinn : Eesti Keele Sihtasutus, 2011
Directory of Open Access Journals (Sweden)
Yrd.Doç.Dr. Akif KETEN
2016-04-01
Full Text Available Son yıllarda meşe ormanlarının öneminin artması bu habitatların daha fazla araştırılma gereksinimini ortaya çıkarmıştır. Bu çalışma Bolu-Yedigöller Yaban Hayatı Geliştirme Sahası’ndaki bir saf meşe meşceresindeki memeli türlerin belirlenmesi amacıyla yapılmıştır. Yaklaşık bir yıl boyunca (Eylül 2013-Temmuz 2014 sabit noktalardan fotokapanlarla gözlemler yapılmıştır. Tespit edilen 10 memeli türe ait 1415 görüntüde 2231 yaban hayvanı bireyi sayılmıştır. Yaban domuzu, karaca ve kızıl tilki alandaki en baskın türlerdir. Meşcerede yaban hayvanları mevsimsel farklılık göstermemektedir. Daha çok beslenme davranışı görülmüştür. Türler genel olarak gececildir. Yaban hayatı bakımından zengin olan meşe meşcerelerinde sürdürülebilir yönetimin devam ettirilmesi önerilmektedir.
Eesti sai OIF-i vaatlejaliikmeks / Tõnu Tender, Tiina Jaksman
Tender, Tõnu, 1965-
2010-01-01
Eesti võeti rahvusvahelise frankofoonia organisatsiooni (OIF) vaatlejaliikmeks. OIF ühendab riike ja piirkondi, mille ametlik keel või haridussüsteemis traditsiooniliselt õpetatav keel on prantsuse keel
Maisla, Diana
1999-01-01
Õpingutest New Brunswicki Ülikoolis eesti keele kui teise keele õpetamise metoodika arendamise projekti "Estonian Language Training Project" raames. New Brunswicki Ülikool. Rööptekst inglise keeles
Nickel-catalyzed direct synthesis of dialkoxymethane ethers
Indian Academy of Sciences (India)
MURUGAN SUBARAMANIAN
Nickel catalysis; alcohol; paraformaldehyde; ether; solvent-free condition. 1. Introduction ..... oxidation and Dopamine Release with Protective Effects. Against Central ... P, Ghosh A, Saha R and Saha B 2016 A Review on the. Advancement of ...
Применение компютеров в языковом классе / Гульнара Валс ; Валс, Гульнара; Валс, Дмитрий
Валс, Гюльнара
2001-01-01
Tutvustatakse kahte inglise keele õppe programmi : "Triple play in English" ja "Star Course". Integreeritud inglise keele tunnist, milles seotakse ajalugu, inglise keel ja informaatika. Integreeritud ajaloo ja vene kirjanduse tunnist kuuendale klassile
Üksikud naljakad peaaegu kolmikud / Jüri Viikberg ; tlk. Jüri Viikberg
Viikberg, Jüri 1953-
2005-01-01
Arvustus: Punttila, Matti. Haaskannäköinen tyttö : kielikaskuista sanaleikkeihin. Helsinki, 1998 ; Punttila, Matti. Pilkettä silmäkulmaan : kielikaskuista sanaleikkeihin. Helsinki, 2001 ; Punttila, Matti. Poskettomia huulia : kielikaskuista sanaleikkeihin. Helsinki, 2004. Näiteid: Kui keel ei püsi hammaste taga ; Sõna keeles ja keel hammaste vahel / tõlkinud Jüri Viikberg // Oma Keel, 1995, nr. 1, lk. 55-56, 63-64
Wŏ shuō hànyŭ, nĭne? ehk Mina räägin hiina keelt, aga sina? / Piret Lakson
Lakson, Piret, 1989-
2012-01-01
Hiina keele õpetamisest Eestis ja Mustamäe gümnaasiumi noorest hiina keele õpetajast Wang Weist. Eesti koolidesse hiina keele õpetajate hankimine käib Tallinna ülikooli juurde loodud Konfutsiuse instituudi kaudu
Histone Deacetylase Inhibition Downregulates Collagen 3A1 in Fibrotic Lung Fibroblasts
Directory of Open Access Journals (Sweden)
Victor J. Thannickal
2013-09-01
Full Text Available Idiopathic pulmonary fibrosis (IPF is a deadly disease characterized by chronic inflammation and excessive collagen accumulation in the lung. Myofibroblasts are the primary collagen-producing cells in pulmonary fibrosis. Histone deacetylase inhibitor (HDACi can affect gene expression, and some, such as suberoylanilide hydroxamic acid (SAHA, are US FDA approved for cancer treatment. In this study, we investigated SAHA’s effects on the expression of collagen III alpha 1 (COL3A1 in primary human IPF fibroblasts and in a murine model of pulmonary fibrosis. We observed that increased COL3A1 expression in IPF fibroblasts can be substantially reduced by SAHA treatment at the level of transcription as detected by RT-PCR; collagen III protein level was also reduced, as detected by Western blots and immunofluorescence. The deacetylation inhibitor effect of SAHA was verified by observing higher acetylation levels of both histone H3 and H4 in treated IPF cells. Chromatin immunoprecipitation (ChIP experiments demonstrated that the reduced expression of COL3A1 by SAHA is with increased association of the repressive chromatin marker, H3K27Me3, and decreased association of the active chromatin marker, H3K9Ac. In our murine model of bleomycin-induced pulmonary fibrosis, the SAHA treated group demonstrated significantly less collagen III, as detected by immunohistochemistry. Our data indicate that the HDACi SAHA alters the chromatin associated with COL3A1, resulting in its decreased expression.
Õppijakeel ja eesti vahekeele korpus / Pille Eslon, Helena Metslang
Eslon, Pille
2007-01-01
Tallinna Ülikooli üld- ja rakenduslingvistika õppetooli juures alustatud vene emakeelega õppijate eesti vahekeele korpuse tööst, eesmärgiga toetada teise keele omandamise teaduslikku uurimist ja eesti keele kui teise keele õpetamise edasist arendamist
Lugupeetud emakeeleõpetaja! / Martin Ehala
Ehala, Martin, 1963-
2006-01-01
Tutvustatakse eesti keele õpikuid: Ehala, Martin. Eesti keele struktuur. Tallinn, 2001 ; Ehala, Martin. Kirjutamise kunst. Tallinn, 2000 ; Ehala, Martin. Eesti kirjakeel. Tallinn, 2002 ; Madisso, Maia. Keele- ja tekstiharjutusi abiturientidele. Tallinn, 2002 ; Ehala, Martin ; Veismann, Tiina jt. Noor keelekasutaja. Tallinn, 2005
Hasso Krulli eepiline pesamuna / Rein Veidemann
Veidemann, Rein, 1946-
2015-01-01
Eesti Kultuurkapitali aastapreemia laureaat Hasso Krull. Arvustus: Krull, Hasso. Pesa : tekstid 2000-2012. Tallinn : Eesti Keele Sihtasutus, 2014 ; Krull, Hasso. Muna : tekstid 1987-2012. Tallinn : Eesti Keele Sihtasutus, 2014 ; Krull, Hasso. Kui kivid olid veel pehmed. Tallinn : Eesti Keele Sihtasutus, 2014
International Nuclear Information System (INIS)
Laurinat, J.E.
1988-10-01
The onset of flow instability (OFI) was measured in the first of a scheduled series of subcooled boiling tests at the Savannah River Heat Transfer Laboratory (HTL). This report summarizes the benchmarking of predictions of the onset of significant voiding (OSV) using Version 16 of the FLOWTRANΩ reactor limits code against the HTL measurements. This study confirms that, for this series of HTL subcooled boiling tests, the Saha-Zuber OSV correlation was a conservative indicator of OFI for Peclet numbers between 30,000 and 80,000. The Saha-Zuber correlation was not a conservative indicator of OFI for Peclet numbers below 30,000. A conservative bound to the Saha-Zuber correlation (the Saha-Zuber constant Stanton number criterion -- 30%) was agreed to at a meeting of SRL, DOE, and the DOE EH and DP review panels. This bound was a conservative indicator of OFI for all measurements in this study
Kim, Min Jung; Oh, Hyun Ju; Kim, Geon A; Suh, Han Na; Jo, Young Kwang; Choi, Yoo Bin; Kim, Dong Hoon; Han, Ho Jae; Lee, Byeong Chun
2015-10-15
Although dog cloning technology has been applied to conservation of endangered canids, propagation of elite dogs, and production of transgenic dogs, the efficiency of cloning is still very low. To help overcome this problem, we evaluated the effect of treating donor cells with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on dog cloning efficiency. Relative messenger RNA expressions of the bax1/bcl2 ratio and Dnmt1 in fibroblasts treated with different concentrations (0, 1, 10, 50 μM) of SAHA and durations (0, 20, 44 hours) were compared. Treatment with 1 μM for 20 hours showed significantly lower bax1/bcl2 and Dnmt1 transcript abundance. Acetylation of H3K9 was significantly increased after SAHA treatment, but H4K5, H4K8 and H4K16 were not changed. After SCNT using control or donor cells treated with SAHA, a total of 76 and 64 cloned embryos were transferred to seven and five recipients, respectively. Three fetuses were diagnosed in both control and SAHA-treated groups by ultrasonography 29 days after the embryo transfer, but there was no significant difference in the pregnancy rate (4.2% vs. 4.3%). In conclusion, although SAHA treatment as used in this study significantly decreased bax1/bcl2 and Dnmt1 transcripts of donor nuclei, as well as increased H3 acetylation, it was not enough to increase in vivo developmental competence of cloned dog embryos. Copyright © 2015 Elsevier Inc. All rights reserved.
Pajusalu, Renate, 1963-
2008-01-01
Käsitletakse eesti keele supiinide kasutuse ebasümmeetriat. Vastavalt eesti keele käändesüsteemi ülesehitusele on supiinidel keelesüsteemis kolm vormi: ma-vorm, mas-vorm ja mast-vorm, kuid keelekasutuses sellist sümmeetriat ei ole.
Parandada püksipõlve augu väljalõikamise teel / Jaak Tomberg
Tomberg, Jaak, 1980-
2010-01-01
Arvustus: Saar, Anti. Kuidas sa ära läksid ja mina maha jäin : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2006 ; Saar, Anti. Nemad kaks : [lühiromaan]. Tallinn : Eesti Keele Sihtasutus, 2008 ; Tekste siledast ruumist : [jutud]. Tallinn : Eesti Keele Sihtasutus, 2009
Uuema tehnoloogia rakendamine võõrkeeleõppe kaugkoolituses / Ingrid Nikopensius
Nikopensius, Ingrid
2001-01-01
Artikkel tutvustab Tartu Ülikoolis 1998.a. okt.-dets. kestnud eesti keele algkursust vene keele baasil, mille sihtgrupiks olid Jõhvi ja Kohtla-Järve venekeelsed õpetajad. Kursuse eesmärgiks oli eesti keele sõnavara ja grammatika õpetamine igapäevase suhtlussituatsiooni tasemel ja kirjutamisoskuse arendamine lihtsamate tekstide loomiseks. Kursusel kasutati Oulu ülikooli täienduskoolituskeskuses välja töötatud veebipõhist õpikeskkonda TELSIpro (Telematic environment for Language Simulations), mis on loodud keeleõpetuse tarvis
2012-04-06
... Memorandum. We revised Pacific Pipe's financial expense ratio calculation to be based on its consolidated financial statements rather than its unconsolidated financial statements as reported. We increased Pacific... Saha Thai's financial expense ratio to zero. For more information on the changes to Saha Thai's COP...
Resonance – Journal of Science Education | Indian Academy of ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Chandan Saha. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 8 August 2012 pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra Chakraborty.
SUUNTA JA MUUTOS. HAVAINTOJA VIRON JA SUOMEN LIIKEVERBEISTÄ
Directory of Open Access Journals (Sweden)
Hannu Tommola
2010-01-01
Full Text Available Suund ja muutumine. Tähelepanekuid eesti ja soome liikumisverbidest. Käesolevas artiklis püütakse selgitada eesti ja soome keele kõige sagedasemate liikumisverbide polüfunktsionaalsust. Soome keele tulla vastab küll põhitähenduses eesti verbile tulema, kuid ei väljenda lahkumist – seda väljendatakse soome keeles verbiga lähteä. Samuti erinevad meie keeled inhoatiivi väljendamises: soome keele kõige tavalisem muutumisverb on tulla, eesti keeles aga saama. Soome keele verbi jäädä ja eesti keele verbi jääma on vaadeldud liikumisverbidena nende võimaliku muutuse presupositsiooni tõttu. Jääma väljendab siiski ka seisundi tekkimise tähendust. See tähendus esineb soome verbil jääda vaid idioomides. Eesti keele jääma on näide polüseemia tüübist, mida on nimetatud enantioseemiaks (ühel ja samal lekseemil on vastandtähendused. Üks läänemeresoome liikumisverbide omapära näiteid on verb käydä/käima, mis võimaldab väljendada kahesuunalist liikumist. Soome ja eesti verbide põhitähendused on sarnased, aga kõigis kasutustes käydä ja käima ei kattu, sest käydä esineb ka muutumisverbina, eesti verbil see tähendus puudub. Lõpuks käsitletakse lühidalt idiomaatilisi väljendeid, nt. tuli kuntoon / meni pieleen ning läks korda/viltu.
Indian Academy of Sciences (India)
deba@theory.saha.ernet.in. Banik Sarmistha, Saha Institute of Nuclear Physics, ... Biswas S K, Department of Theoretical Physics, IACS, Jadavpur, Kolkata 700 032. Bordalo Paula, LIP, Av. Elios Garcia 14, 1000 .... Nakagawa Hisao, Institute of Nuclear Sciences, Nara University, 1500 Misasagi-Cho,. Nara 631-8502, Japan.
Tõlkepoeetikast teksti ja keele taustal / On the Poetics of Translation
Directory of Open Access Journals (Sweden)
Anne Lange
2016-01-01
In order to illustrate the practical implications of this approach, the article highlights translational solutions that cannot be explained in linguistic terms given that they attempt to maintain the specifics of the original. The translator proceeds by pretending to know what a text (and its author is doing; it is the cognitive filter of the translator that gives the source text its meaning. In an account of her translation of Jaan Malin’s ”Keele meel“ into English, Miriam McIlfatrick-Ksenofontov begins with the analysis of the poem. This entails separating the whole into its component parts and identifying their relations. Reading with a view to translating unravels the texture of a poem, exposing the lexical, semantic and phonetic strands that constitute its coherence. The article then offers an account of how the translator experiences the original and navigates through it towards a new poem in translation, recognising that languages differ in what they can and must do. The latter, primarily a grammatical reality, is accompanied by a semantic one: the implications that stem from lexical connotations are inevitably different in the original poem and in the new poem. However, the supposed intent of the original is what a cognitive approach sees as a possibility of translation. This does not involve the transferral of isolated lexicalised items, but allows the translator to overcome the dilemma of retaining both form and content by adopting the role of writer, by working with language that is at no more at her disposal than it is for the writer of the original. The analysis of the original enables the translator to avoid seeing the poem as fixed language in a solid object or searching for a single invariant meaning. Between the reader and the poem a situation of dialogue is established that involves asking questions of the poem in order to find what meanings it insists on. Questions like what does this word (image, rhyme, comma, etc. do in/to the poem? how
Riiklikud keeleprogrammid / Jüri Valge
Valge, Jüri, 1948-
2004-01-01
Ülevaade järgmistest keelega seotud programmidest : "Eesti keel ja rahvuslik mälu (2004-2008)", "Humanitaar- ja loodusteaduslikud kogud (2004-2008)", "Rahvuskaaslaste programm (2004-2008)", "Hõimurahvaste programm (2000-2004)", "Lõunaeesti keele ja kultuuri programm (2000-2004)", "Setu kultuuriprogramm", "Eesti keele akadeemilise välisõppe programm"
Experimental study of average void fraction in low-flow subcooled boiling
International Nuclear Information System (INIS)
Sun Qi; Wang Xiaojun; Xi Zhao; Zhao Hua; Yang Ruichang
2005-01-01
Low-flow subcooled void fraction in medium pressure was investigated using high-temperature high-pressure single-sensor optical probe in this paper. And then average void fraction was obtained through the integral calculation of local void fraction in the cross-section. The experimental data were compared with the void fraction model proposed in advance. The results show that the predictions of this model agree with the data quite well. The comparisons of Saha and Levy models with low-flow subcooled data show that Saha model overestimates the experimental data distinctively, and Levy model also gets relatively higher predictions although it is better than Saha model. (author)
With or without articles? A comparison of article-like determiners in Estonian and Finnish
Directory of Open Access Journals (Sweden)
Helen Hint
2017-10-01
Full Text Available In this paper, we compare the use and functions of definite and indefinite article-like determiners in Estonian and Finnish. Our main aim is to explore whether the factors that explain the choice of particular determiner forms are similar in Estonian and Finnish. We use a picture-sequence based elicitation experiment to collect spoken narratives from adult native speakers of Estonian and Finnish, and apply non-parametric tree and forest models to analyze the data. Our findings indicate that number of mention and animacy are important predictor variables in both languages, but their exact effect is divergent. We also find that in Finnish, case of the determiner NP proves to be an important factor, while in Estonian, syntactic role of the NP explains some aspects of determiner form choice. Nevertheless, the overall usage frequency of determiners is modest in the Estonian and Finnish data, and the process of grammaticalizing articles is only in initial stages in both languages. *** Artikliga, artiklita? Eesti ja soome keele artiklilaadsete määratlejate võrdlus Siinses uurimuses analüüsime võrdlevalt artiklilaadseid definiitseid ja indefiniitseid määratlejaid eesti ja soome keeles. Eelkõige kõrvutame eesti keele definiitset määratlejat see ja soome keele definiitseid määratlejaid se ja tämä ning eesti ja soome indefiniitset määratlejat üks/yks(i. Samuti vaatleme eesti keele possessiivpronoomeni oma ning soome 3sg possessiivsufiksi (-nsa/-nsä, -Vn referentsiaalseid omadusi. Uurimuse põhieesmärgiks on selgitada, millised on peamised määratlejate kasutust mõjutavad keelelised faktorid eesti ja soome keeles ning kas need faktorid on keeliti sarnased või erinevad. Ühtlasi otsime vastust küsimusele, kas eesti ja soome keeles on põhjust rääkida määratlejate grammatisatsioonist artikliteks. Uuritav keelematerjal pärineb pildiseeria põhjal kogutud suulistest narratiividest. Uurimuses osales 20 eesti ja 20 soome keele
Indian Academy of Sciences (India)
srimathi
Adhikari Sucheta, NRS Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar,. Kolkata 700 064, India (sucheta@hp1.saha.ernet.in). Ansari M Afzal, Department of Physics, Aligarh Muslim University, Aligarh 202 002, India. Telex: 564-230 AMU IN. Arumugam P, Department of Physics, M. S. University, Tirunelveli ...
2013-04-09
.../exporters of the subject merchandise, Saha Thai Steel Pipe (Public) Company, Ltd. (Saha Thai), and Pacific Pipe Company Limited (Pacific Pipe). The period of review (POR) is March 1, 2011, through February 29...) Company, Ltd 0.00 Pacific Pipe Company Limited * * No shipments or sales subject to this review. The firm...
Preparation of diamond like carbon thin film on stainless steel and ...
Indian Academy of Sciences (India)
Author Affiliations. Kamlesh Kumari1 S Banerjee2 T K Chini2 N R Ray3. Amity Institute of Nanotechnology, Amity University, Noida 201 303, India; Surface Physics Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India; Plasma Physics Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India ...
International Nuclear Information System (INIS)
Blattmann, Claudia; Oertel, Susanne; Ehemann, Volker
2010-01-01
Purpose: Histone deacetylase inhibitors (HDACIs) can enhance the sensitivity of cells to photon radiation treatment (XRT) by altering numerous molecular pathways. We investigated the effect of pan-HDACIs such as suberoylanilide hydroxamic acid (SAHA) on radiation response in two osteosarcoma (OS) and two rhabdomyosarcoma (RMS) cell lines. Methods and Materials: Clonogenic survival, cell cycle analysis, and apoptosis were examined in OS (KHOS-24OS, SAOS2) and RMS (A-204, RD) cell lines treated with HDACI and HDACI plus XRT, respectively. Protein expression was investigated via immunoblot analysis, and cell cycle analysis and measurement of apoptosis were performed using flow cytometry. Results: SAHA induced an inhibition of cell proliferation and clonogenic survival in OS and RMS cell lines and led to a significant radiosensitization of all tumor cell lines. Other HDACI such as M344 and valproate showed similar effects as investigated in one OS cell line. Furthermore, SAHA significantly increased radiation-induced apoptosis in the OS cell lines, whereas in the RMS cell lines radiation-induced apoptosis was insignificant with and without SAHA. In all investigated sarcoma cell lines, SAHA attenuated radiation-induced DNA repair protein expression (Rad51, Ku80). Conclusion: Our results show that HDACIs enhance radiation action in OS and RMS cell lines. Inhibition of DNA repair, as well as increased apoptosis induction after exposure to HDACIs, can be mechanisms of radiosensitization by HDACIs.
Vedru, Gurly, 1970-
2009-01-01
Kaevamistest Harjumaal Saha külas ja Raplamaal Kalbu külas. Sahas uuriti keskaegset kivist kabeliaeda. Kalbu külas toimusid päästekaevamised Räägu-Uueotsa talu alal paikneval kalmel. Leitud müntide põhjal võib oletada, et Kalbu kalmesse maeti 17. sajandil ning 18. saj. algul
Directory of Open Access Journals (Sweden)
S. B. Jagtap
2013-04-01
Full Text Available Epoxy/multiwall carbon nanotubes (MWCNT composites were prepared using sodium salt of 6-aminohexanoic acid (SAHA modified MWCNT and its effect properties of related composites were investigated. The composite prepared using a polar solvent, tetrahydrofuran exhibits better mechanical properties compared to those prepared using less polar solvent and without using solvent. The tensile properties and dynamic storage modulus was found to be increased as a result of modification of MWCNT with SAHA. This improvement in the tensile properties and dynamic mechanical properties of epoxy/MWCNT composite is a combined effect of cation-π interaction and chemical bonding. Fourier transform infrared spectroscopy (FTIR and Raman spectroscopy were used to explain cation-π interaction between SAHA with MWCNT and chemical bonding of SAHA with epoxy resin. The effect of modification of MWCNT on morphology of a nanocomposite was confirmed by using scanning electron microscopy (SEM and transmission electron microscopy (TEM. The present approach does not disturb the ! electron clouds of MWCNT as opposed to chemical functionalization strategy.
Mineralogical and chemical characteristics of newer dolerite dyke ...
Indian Academy of Sciences (India)
Dunn and Dey 1942; Saha 1948, 1952; Saha et al. 1972, 1973). ... nuclei of the Indian landmass (Basu et al. 1981;. Goswami ... Geochemistry. In order to get an idea about petrogenetic process ...... Greenough John D, Fryer Brian J and Robinson Paul T ... 643–660. Mc Mullin David W A, Barr Sandra M and Raeside Robert.
Lõunaeestlased turgutavad Ida-Virus oma vene keelt / Sirle Sommer Kalda
Sommer-Kalda, Sirle, 1974-
2009-01-01
Euroopa Sotsiaalfondist rahastatava programmi "Keeleõppe arendamine 2007-2010" raames toimunud tööjõuvahetusest, mille käigus kevadel Ida-Virumaa linnade ametnikud ja allasutuste töötajad asusid ajutiselt tööle Lõuna- ja Lääne-Eestis, et parandada oma eesti keele oskust ja lõunaeestlaste vastukülaskäigust Ida-Virumaale vene keele oskuste parandamiseks
Evaluation of 4 years of continuous δ13C(CO2) data using a moving Keeling plot method
Vardag, Sanam Noreen; Hammer, Samuel; Levin, Ingeborg
2016-07-01
Different carbon dioxide (CO2) emitters can be distinguished by their carbon isotope ratios. Therefore measurements of atmospheric δ13C(CO2) and CO2 concentration contain information on the CO2 source mix in the catchment area of an atmospheric measurement site. This information may be illustratively presented as the mean isotopic source signature. Recently an increasing number of continuous measurements of δ13C(CO2) and CO2 have become available, opening the door to the quantification of CO2 shares from different sources at high temporal resolution. Here, we present a method to compute the CO2 source signature (δS) continuously and evaluate our result using model data from the Stochastic Time-Inverted Lagrangian Transport model. Only when we restrict the analysis to situations which fulfill the basic assumptions of the Keeling plot method does our approach provide correct results with minimal biases in δS. On average, this bias is 0.2 ‰ with an interquartile range of about 1.2 ‰ for hourly model data. As a consequence of applying the required strict filter criteria, 85 % of the data points - mainly daytime values - need to be discarded. Applying the method to a 4-year dataset of CO2 and δ13C(CO2) measured in Heidelberg, Germany, yields a distinct seasonal cycle of δS. Disentangling this seasonal source signature into shares of source components is, however, only possible if the isotopic end members of these sources - i.e., the biosphere, δbio, and the fuel mix, δF - are known. From the mean source signature record in 2012, δbio could be reliably estimated only for summer to (-25.0 ± 1.0) ‰ and δF only for winter to (-32.5 ± 2.5) ‰. As the isotopic end members δbio and δF were shown to change over the season, no year-round estimation of the fossil fuel or biosphere share is possible from the measured mean source signature record without additional information from emission inventories or other tracer measurements.
Directory of Open Access Journals (Sweden)
Darren M Hutt
Full Text Available Hypoxia inducible factor 1α (HIF-1α is a master regulator of tumor angiogenesis being one of the major targets for cancer therapy. Previous studies have shown that Histone Deacetylase Inhibitors (HDACi block tumor angiogenesis through the inhibition of HIF-1α expression. As such, Vorinostat (Suberoylanilide Hydroxamic Acid/SAHA and Romidepsin, two HDACis, were recently approved by the Food and Drug Administration (FDA for the treatment of cutaneous T cell lymphoma. Although HDACis have been shown to affect HIF-1α expression by modulating its interactions with the Hsp70/Hsp90 chaperone axis or its acetylation status, the molecular mechanisms by which HDACis inhibit HIF-1α expression need to be further characterized. Here, we report that the FDA-approved HDACi Vorinostat/SAHA inhibits HIF-1α expression in liver cancer-derived cell lines, by a new mechanism independent of p53, prolyl-hydroxylases, autophagy and proteasome degradation. We found that SAHA or silencing of HDAC9 mechanism of action is due to inhibition of HIF-1α translation, which in turn, is mediated by the eukaryotic translation initiation factor--eIF3G. We also highlighted that HIF-1α translation is dramatically inhibited when SAHA is combined with eIF3H silencing. Taken together, we show that HDAC activity regulates HIF-1α translation, with HDACis such as SAHA representing a potential novel approach for the treatment of hepatocellular carcinoma.
Reguart, Noemi; Rosell, Rafael; Cardenal, Felipe; Cardona, Andres F; Isla, Dolores; Palmero, Ramon; Moran, Teresa; Rolfo, Christian; Pallarès, M Cinta; Insa, Amelia; Carcereny, Enric; Majem, Margarita; De Castro, Javier; Queralt, Cristina; Molina, Miguel A; Taron, Miquel
2014-05-01
Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a novel histone deacetylase inhibitor with demonstrated antiproliferative effects due to drug-induced accumulation of acetylated proteins, including the heat shock protein 90. We prospectively studied the activity of vorinostat plus erlotinib in EGFR-mutated NSCLC patients with progression to tyrosine kinase inhibitors. We conducted this prospective, non-randomized, multicenter, phase I/II trial to evaluate the maximum tolerated dose, toxicity profile and efficacy of erlotinib and vorinostat. Patients with advanced NSCLC harboring EGFR mutations and progressive disease after a minimum of 12 weeks on erlotinib were included. The maximum tolerated dose of vorinostat plus erlotinib was used as recommended dose for the phase II (RDP2) to assess the efficacy of the combination. The primary end point was progression-free-survival rate at 12 weeks (PFSR12w). Pre-treatment plasma samples were required to assess T790M resistant mutation. A total of 33 patients were enrolled in the phase I-II trial. The maximum tolerated dose was erlotinib 150 mg p.o., QD, and 400mg p.o., QD, on days 1-7 and 15-21 in a 28-day cycle. Among the 25 patients treated at the RDP2, the most common toxicities included anemia, fatigue and diarrhea. No responses were observed. PFSR12w was 28% (IC 95%: 18.0-37.2); median progression-free survival (PFS) was 8 weeks (IC 95%: 7.43-8.45) and overall survival (OS) 10.3 months (95% CI: 2.4-18.1). Full dose of continuous erlotinib with vorinostat 400mg p.o., QD on alternative weeks can be safely administered. Still, the combination has no meaningful activity in EGFR-mutated NSCLC patients after TKI progression. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Mis tulemust teie meeleavalduselt ootate? / Liivi Kulli, Jaanus Gross, Mari-Viivian Laht ... [jt.
2011-01-01
Küsimusele vastasid Rakvere reaalgümnaasiumi inglise ja saksa keele õpetaja Liivi Kulli, Turba gümnaasiumi arvutiõpetuse õpetaja Jaanus Gross, Kiltsi põhikooli eesti keele ja kirjanduse õpetaja Mari-Viivian Laht, Ruusa kooli ja Mikitamäe põhikooli inglise keele õpetaja Anne Must, Kunda ühisgümnaasiumi klienditeeninduse õpetaja Evely Press, Tõstamaa keskkooli käsitöö- ja kunstiõpetaja, Inger Vahuvee, prantsuse lütseumi kehalise kasvatuse õpetaja Urmas Kokk, Tõnismäe reaalkooli kehalise kasvatuse õpetaja Mihhail Tõrtõšnõi, Ruila põhikooli inglise keele õpetaja Margit Levoll, ametiühingute keskliidu juht Harri Taliga
Eesti keele riiklike tasemetööde tekstimõistmisülesannete analüüs
Directory of Open Access Journals (Sweden)
Triinu Kärbla
2017-05-01
Full Text Available "Analysis of the comprehension tasks of national standardised tests of Estonian language" Text comprehension is a complex process where low- and high-level skills are likely to interact. In this article the comprehension tasks of national standardised tests of Estonian language for Grade 6 in 2013–2015 are analysed to detect levels of text comprehension in standardised tests. We found that the comprehension tasks in standardised tests are mostly focused on factual knowledge. Furthermore, 76% of questions in the national standardised test in 2014 and 57.1% in 2015 consisted of tasks which measured children’s ability to recall the details from the read or heard text. In 2013, such tasks comprised 42.9% of the national standardised test. We found only one task (in 2013 which demanded the highest skills – implementing pre-knowledge into the evaluation process. Thus, the tasks used in standardised test are not wide-ranging enough to determine students’ skills at different levels of text comprehension. As long as national standardised tests consist mostly of tasks that require readers’ memory, teachers also concentrate mainly on supporting students’ lower-level text comprehension skills. Therefore, there may not be enough attention devoted to developing the students’ high-level skills. As text comprehension at higher level is one of the most important competences students must acquire for successful academic and lifelong growth, teachers should concentrate more on supporting these skills. Teksti mõistmine on protsess, mis eeldab madalama ja kõrgema tasandi oskuste rakendamist. Selles artiklis analüüsitakse 2013.–2015. aastal tehtud 6. klassi eesti keele riiklike tasemetööde ülesandeid, et selgitada välja, millistel tekstimõistmistasanditel hinnatakse õpilaste oskusi. Analüüsist selgub, et ülesannetes keskenduti peamiselt õpilaste faktiteadmiste kontrollimisele. Seejuures olid 2014. ja 2015. aasta tasemetööd koostatud
Настольная игра помогает изучать русский язык и Россию / Андрей Бабин
Бабин, Андрей
2013-01-01
Õppemängu CONTACT© Russian eesmärk on Moskva linnas ning vene kultuuris mugavalt orienteeruma ja vene keeles suhtlema õppimine. Tallinna Ülikooli poolt on koostatud analoogne mäng välistudengitele vene keele õppimiseks inglise keele baasil. Mängu koostasid Slaavi Keelte ja Kultuuride Instituudi lektor Inna Adamson ja Katariina Kolledži direktor Dimitri Mironov, kes jagab mängu kohta selgitusi
Mailis Reips : Prezhde vsego neobhodimo natshat / Mailis Reps
Reps, Mailis, 1975-
2006-01-01
Haridusminister Mailis Reps kakskeelse hariduse vajalikkusest vene õppekeelega koolides, noorte keeleoskusest, eesti keele õpetamise kvaliteedist, õpetajate eesti keele oskusest, õppetöö kvaliteedist
2013-01-01
Uuritakse, millistele tingimustele peaksid vastama keeleõppijatele mõeldud elektroonilised sõnastikud ning tutvustatakse uut soome keele õppijatele ja õpetajatele loodud veebisõnastikku ConLexis
Ungaris eesti keelt õppivate üliõpilaste kommunikatiivne kompetents
Directory of Open Access Journals (Sweden)
Marju Ilves
2006-05-01
Full Text Available Kommunikatiivne kompetents on võime keelt tõhusalt ja olukorrale vastavalt kasutada, sisuliselt tähendab see suhtlemisoskust. Kommunikatiivse kompetentsi moodustavad leksikaalne, sotsiolingvistiline/sotsiokultuuriline ja pragmaatiline kompetents. Eesti keele õpetamine välismaal toimub peaasjalikult deskriptiivselt. Ungarlastele mõeldud eesti keele õpik pakub deskriptiivse materjali kõrval lugemispalu ja näitedialooge suhtlussituatsioonide kohta, kommunikatiivsed ülesanded õpikus puuduvad. Kommunikatiivse keeleõppemeetodi kasutamine keeletunnis valmistab keeleõppijat ette teatud tüüpilisteks suhtlussituatsioonideks, millega ta keelekeskkonda sattudes kohe kokku puutub. Koostasin ungarlastest eesti keelt õppinud/õppivatele üliõpilastele mõned lihtsamad suhtlussituatsiooni kirjeldused, milles oli antud suhtluseesmärk ning oli vaja leida keelelised vahendid selle lahendamiseks (nt Kuidas küsid tänaval kella?. Kontrollmaterjalina kasutasin Tartu Ülikooli eestlastest üliõpilaste ja Szombathely Kõrgkooli ungarlastest üliõpilaste vastuseid. Uurimusest selguvad mõned kultuurilised erinevused ja see, kuivõrd on Ungaris eesti keele õppija ette valmistatud autentseteks suhtlussituatsioonideks.
Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy
International Nuclear Information System (INIS)
Blattmann, Claudia; Oertel, Susanne; Thiemann, Markus; Dittmar, Anne; Roth, Eva; Kulozik, Andreas E.; Ehemann, Volker; Weichert, Wilko; Huber, Peter E.; Stenzinger, Albrecht; Debus, Jürgen
2015-01-01
Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model. Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated. Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21 Waf1/Cip1 , inhibition of proliferation and angiogenesis compared to tumors treated with HIT only. HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials
Toimetaja on autori teine, täpsem silmapaar / Reili Argus
Argus, Reili, 1967-
2010-01-01
Intervjuu Tallinna Ülikooli eesti keele ja kultuuri instituudi direktori, eesti keele dotsendi Reili Argusega Tallinna Ülikooli referent-toimetaja bakalaureuseõppekavast ja keeletoimetaja magistriõppekavast
Christine ja krepid Rakvere ametikoolis / Ada Väät
Väät, Ada
2014-01-01
Lyoni kutsekooli inglise keele õpetaja Christine Crimalault tuli Rakvere ametikooli Erasmuse programmi kaudu. Eestis külastas ta ametikooli tunde, osales kultuuriprogrammis ja kohtus siinsete keeleõpetajatega
2017-02-01
long range aero-medical evacuation in hypobaric environments on the physiology and organ function of injured warfighters, thus potentially and...currently ongoing. REPORTABLE OUTCOMES: Steve Chun, MD; Ashraful Haque, MD; Brittany Hazzard, BS; Saha Biswajit, MD, Martin Harssema, MD, Charles Auker...Scultetus MD; Ashraful Haque, MD; Brittany Hazzard, BS; Saha Biswajit, MD; Steve Chun, MD; Martin Harssema, MD; Charles Auker, MD, PhD; Debra Malone
"Ametniku soovitussõnastik" / Tuuli Rehemaa
Rehemaa, Tuuli, 1974-
2014-01-01
Tutvustus: Ametniku soovitussõnastik [Võrguteavik] / Eesti Keele Instituut ; koostanud ja toimetanud Tiina Paet, Tuuli Rehemaa, Argo Mund. Tallinn : Eesti Keele Sihtasutus, 2014. - http://www.eki.ee/dict/ametnik/
Eesti suulise keele korpus keeleõppedialoogide lähtematerjalina: telefonivestluste koostamine
Directory of Open Access Journals (Sweden)
Raili Pool
2011-10-01
Full Text Available Language authenticity in study materials and related learning activities are very important for foreign language teaching. Telephone conversations included in textbooks of Estonian as a second language are often not realistic with respect to the structure of their openings and closings. ne method to make Estonian language learning dialogues more realistic is to incorporate the corpus of spoken Estonian of the University of Tartu as the source.
O merahh po dalneishemu ulutshsheniju polozhenija / Boris Tuch
Tuch, Boris, 1946-
2006-01-01
Autori arvates tuleks vene gümnaasiumide reformimise asemel parandada eesti keele õpetamise kvaliteeti ja motiveerida õppureid. Näiteid vene keele väärkasutusest erakondade ajalehtedes ja valimisloosungitel
Directory of Open Access Journals (Sweden)
Deniz Tansel İLİC
2014-09-01
Full Text Available Kültürel simgelerin üretim sürecinde görev yapan enformasyon işçilerinin özerkliği, sosyal bilimler açısından önemli bir tartışma konusudur. Üretim sürecini sadece sahiplik üzerinden değerlendiren yaklaşımlar, mülkiyet ilişkilerinin, simge üreticisinin özerklik alanını tamamen kısıtlayacağını savunurlar. Yine de, zihinsel emekleri ile çalışan simge üreticilerinin, belli oranda özerkliğe sahip olduğu iddiası sınamaya değerdir. Bu çalışmada, David Hesmondhalgh ve Mike Wayne’deki göreli özerklik vurgusundan yola çıkarak, Türkiye’de anaakım televizyon haberciliğinde bir saha araştırması yapılmıştır. Fox TV, TGRT Haber ve Kanal D’de gerçekleştirilen katılımlı gözlemlerle, birer simge üreticisi olan habercilerin, hangi oranda özerk oldukları saptanmaya çalışılmıştır. / The autonomy of information workers who work in the production process of cultural symbols is an important issue for social sciences. The approaches that evaluate the production process only in the context of ownership claim that these relationships will restrain the autonomy field of the symbol producer. Still the suggestion that symbol producers who work with their mental labours have a certain amount of autonomy is worth testing. In this study a field research is conducted in mainstream broadcasting in Turkey by using the relative autonomy emphasis in David Hesmondhalgh and Mike Wayne as a starting point. In the participant observation that is conducted in Fox TV, TGRT Haber and Kanal D Televisions it is tried to determine at what level the journalists as symbol producers are autonomous.
Viron kieli toisena kielenä - opetuksesta Tarton yliopistossa 1820-luvun lopulla / Heli Laanekask
Laanekask, Heli, 1950-
2013-01-01
Artiklis analüüsitakse Tartu Ülikooli eesti keele lektori Johann Samuel Friedrich Boubrigi õpetamise metoodikat, kasutatud allikaid ja loengute sisu. Puudutatakse ka sugulaskeelte - soome ja ungari keele õpetust
Käsper, Marge, 1973-
2005-01-01
Kõrvutatakse eesti ja prantsuse teksti, vaadeldakse, kuidas mõlemas keeles teksti seotakse ning isikutevahelisi suhteid väljendatakse. Analüüsitakse Astrid Lindgreni "Hulkur Rasmuse" tekste mõlemas keeles
Vene koolide valmisolekust üleminekuks eesti õppekeelega gümnaasiumile 2007. aastal / Silvi Vare
Vare, Silvi, 1939-
2006-01-01
Eesti keele õppe seisust ja riiklikust korraldusest vene põhikoolis, koolilõpetajate eesti keele oskuse tasemest ning koolikorralduslikest muutustest aastatel 1997-2005 seoses eestikeelsele gümnaasiumiõppele üleminekuga
Üks vormiõpetus (I) : Vaimumõõgad / Henn Saari
Saari, Henn, 1924-1999
1998-01-01
Diskussioonist eesti nüüdiskeele võrmiõpetuse ning selle eelduseks oleva fooniasüsteemi üle uut õigekeelsussõnaraamatut ette valmistades. Vt. ka: Ehala, Martin. Eesti morfoloogia olemus // Keel ja Kirjandus, 1997, nr. 6 ; Hint, Mati. Eesti foneetika möödunud hiilgus ja möödumata viletsus // Keel ja Kirjandus, 1997, nr. 2 ; Ross, Kristiina. Eesti morfo(fono)loogia põnevamad probleemid : EKG contra Mati Hint // Keel ja Kirjandus, 1997, nr. 5
Uus keelenimetus ärritab Rumeeniat / Ingrid Cristea
Cristea, Ingrid
2007-01-01
Moldova otsustas seal kõneldavat rumeenia keele dialekti nimetada edaspidi moldova keeleks, Rumeenia ei tunnista moldova keele olemasolu. Euroopa Parlamendi liige Roberta Anastase hinnangul peab Euroopa Komisjon tunnistama ainult rumeenia keelt
Keelehoolde teoreetilise aluse otsinguil : naabervaldkonnad appi / Arvi Tavast
Tavast, Arvi, 1969-
2012-01-01
Kajastatakse e-keskkonnas läbiviidud küsitluse tulemusi, milles otsiti keele- ja tõlkimisalaste hoiakute seoseid muude teemadega. Küsiti keele olemuse, keelekasutuse, õigeks ja valeks jagamise jne. kohta
Studies on EOS of shock-generated argon plasmas
International Nuclear Information System (INIS)
Wang Fanhou; Jing Fuqian
2001-01-01
The equation of state for argon plasma, covering the thermodynamic states of 10000-30000 K in temperature and 0.0133-0.166 GPa in pressure, is computed using the Saha model and Debye-Huckel correction. Comparisons of the measured EOS with the calculated ones demonstrate the Saha model and Debye-Huckel correction can be used to well describe the essential behavior of argon plasma under the thermodynamic condition above-mentioned
Uss uuristab inimese südame kallal / Kärt Hellerma
Hellerma, Kärt, 1956-
2003-01-01
Arvustus: [Õnnepalu, Tõnu] Tode, Emil. Raadio. Tallinn : Eesti Keele Sihtasutus, 2002. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 47-53
39. Balti Rahvaste Kommersi aktusel / Lennart Meri
Meri, Lennart, 1929-2006
2007-01-01
Eesti keel, eesti mõtteviis, eesti kultuur on seisustevahelisest konfliktist hoolimata arenenud saksa keele najal, aga ka baltisaksa keelt mõjutades. Tartu ülikooli traditsioonid. Kõne Münchenis 25. mail 2002. a.
EuroPlus+ Reward / Alar Hammer
Hammer, Alar
2000-01-01
EuroPlus+ Reward on mitmes versioonis ilmunud inglise keele õppeprogramm, milles on ühendatud multimeedia võimalused ning distantsõpe ning mis loob täiesti uued võimalused keele omandamiseks arvuti abil
Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model
International Nuclear Information System (INIS)
Blattmann, C.; University Children's Hospital of Heidelberg; Thiemann, M.; Stenzinger, A.
2013-01-01
Background: Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. Methods: Clonogenic survival of human OS cell lines as well as tumor growth delay of OS xenografts were tested after treatment with either vehicle, radiotherapy (XRT), SAHA, or XRT and SAHA. Tumor proliferation, necrosis, microvascular density, apoptosis, and p53/p21 were monitored by immunohistochemistry. The CD95 pathway was performed by flow cytometry, caspase (3/7/8) activity measurements, and functional inhibition of CD95 death signaling. Results: Combined treatment with SAHA and XRT markedly reduced the surviving fraction of OS cells as compared to XRT alone. Likewise, dual therapy significantly inhibited OS tumor growth in vivo as compared to XRT alone, reflected by reduced tumor proliferation, impaired angiogenesis, and increased apoptosis. Addition of HDACi to XRT led to elevated p53, p21, CD95, and CD95L expression. Inhibition of CD95 signaling reduced HDACi- and XRT-induced apoptosis. Conclusion: Our data show that HDACi increases the radiosensitivity of osteosarcoma cells at least in part via ligand-induced apoptosis. HDACi thus emerge as potentially useful treatment components of OS. (orig.)
Radiosensitization by histone deacetylase inhibition in an osteosarcoma mouse model
Energy Technology Data Exchange (ETDEWEB)
Blattmann, C. [Olgahospital, Stuttgart (Germany). Paediatrie 5; University Children' s Hospital of Heidelberg (Germany). Dept. of Pediatric Oncology, Hematology and Immunology; Thiemann, M. [German Cancer Research Center (DKFZ), Heidelberg (Germany). Dept. of Radiotherapy, Molecular- and Translational Radiation Oncology; Stenzinger, A. [Heidelberg Univ. (Germany). Inst. of Pathology; and others
2013-11-15
Background: Osteosarcomas (OS) are highly malignant and radioresistant tumors. Histone deacetylase inhibitors (HDACi) constitute a novel class of anticancer agents. We sought to investigate the effect of combined treatment with suberoylanilide hydroxamic acid (SAHA) and radiotherapy in OS in vivo. Methods: Clonogenic survival of human OS cell lines as well as tumor growth delay of OS xenografts were tested after treatment with either vehicle, radiotherapy (XRT), SAHA, or XRT and SAHA. Tumor proliferation, necrosis, microvascular density, apoptosis, and p53/p21 were monitored by immunohistochemistry. The CD95 pathway was performed by flow cytometry, caspase (3/7/8) activity measurements, and functional inhibition of CD95 death signaling. Results: Combined treatment with SAHA and XRT markedly reduced the surviving fraction of OS cells as compared to XRT alone. Likewise, dual therapy significantly inhibited OS tumor growth in vivo as compared to XRT alone, reflected by reduced tumor proliferation, impaired angiogenesis, and increased apoptosis. Addition of HDACi to XRT led to elevated p53, p21, CD95, and CD95L expression. Inhibition of CD95 signaling reduced HDACi- and XRT-induced apoptosis. Conclusion: Our data show that HDACi increases the radiosensitivity of osteosarcoma cells at least in part via ligand-induced apoptosis. HDACi thus emerge as potentially useful treatment components of OS. (orig.)
Veski - Peegli liinilt / Ellen Uuspõld ; vestelnud Maarja Lõhmus
Uuspõld, Ellen, 1927-
2014-01-01
Juhan Peegel eesti keele kateedri aspirandi ja õppejõuna ning ajaloo-keeleteaduskonna dekaanina. Ka Ellen Uuspõllu õpingutest Tartu Riikliku Ülikooli kaugõppes alates 1945 ning tööst eesti keele kateedris
Langemets, Margit, 1961-
2005-01-01
Süntaktilise info esitusest elektroonilistes sõnastikes ja suurtes leksikaalsetes andmebaasides. Süntaktilise info valikukriteeriumidest ja esitusviisidest Eesti Keele Instituudi uute sõnastikuprojektide, ennekõike eesti-X-keele sõnastiku tarvis. Andmetega autorite kohta
Mike Garant Ameerika ühiskonna probleemidest
2000-01-01
44. nädalal külastas inglise keele õppetooli dr Mike Garant Helsingi ülikoolist. Mike Garant käsitles oma loengutes multikulturaalse Ameerika ühiskonna probleeme (mobiilsus, identiteet, keel) : [täistekst
Abrosimova, Natalia
2008-01-01
Ülevaade ersa keele õpetamisest üldhariduskoolides, samuti tuuakse välja ankeetküsitluse tulemused, kus lapsed ja nende vanemad vastasid küsimustele keele kasutamise, keeleoskuse, oma rahva ja kultuuri ajaloo jms. kohta
Fillbrandt, Eva-Liisa
2006-01-01
Tingiva kõneviisi kasutusest varases moodsa inglise perioodis aastatel 1500-1700. Uurimus tõi välja kaks inglise keele varianti - varase moodsa inglise lõuna variandi ja vanema šoti inglise keele põhjavariandi
Ilusast eesti keelest / Ruth Mägi
Mägi, Ruth, 1974-
2008-01-01
Kirjastuse TEA sõnaraamatutest: TEA koolisõnastik : eesti keel. Tallinn : TEA Kirjastus, 2008 ; TEA eesti keele rahvasõnaraamat koos õigekirjareeglitega. Tallinn : TEA Kirjastus, 2008 ; TEA rahvasõnaraamat : võõrsõnad. Tallinn : TEA Kirjastus, 2006
1 Medium Regiment, (SAHA), SAA
African Journals Online (AJOL)
Scientia Militaria: South African Journal of Military Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 16, No 4 (1986) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. 1 Medium Regiment, (S.A.H.A.), ...
On the Saha Ionization Equation
Indian Academy of Sciences (India)
the equation in terms of rate theory. ... that the said theory is said to be the harbinger of modern astro- ... Parichay (An Introduction to the Universe). Tagore ..... where |e| is the magnitude of the electron's charge and E is the electric field intensity ...
International Nuclear Information System (INIS)
Terry, Samantha Y.A.; Vallis, Katherine A.
2012-01-01
Purpose: The open structure of euchromatin renders it susceptible to DNA damage by ionizing radiation (IR) compared with compact heterochromatin. The effect of chromatin configuration on the efficacy of Auger electron radiotherapy was investigated. Methods and Materials: Chromatin structure was altered in MDA-MB-468 and 231-H2N human breast cancer cells by suberoylanilide hydroxamic acid (SAHA), 5-aza-2-deoxycytidine, or hypertonic treatment. The extent and duration of chromatin structural changes were evaluated using the micrococcal nuclease assay. DNA damage (γH2AX assay) and clonogenic survival were evaluated after exposure to 111 In-DTPA-hEGF, an Auger electron-emitting radiopharmaceutical, or IR. The intracellular distribution of 111 In-DTPA-hEGF after chromatin modification was investigated in cell fractionation experiments. Results: Chromatin remained condensed for up to 20 minutes after NaCl and in a relaxed state 24 hours after SAHA treatment. The number of γH2AX foci per cell was greater in MDA-MB-468 and 231-H2N cells after IR (0.5 Gy) plus SAHA (1 μM) compared with IR alone (16 ± 0.6 and 14 ± 0.3 vs. 12 ± 0.4 and 11 ± 0.2, respectively). More γH2AX foci were observed in MDA-MB-468 and 231-H2N cells exposed to 111 In-DTPA-hEGF (6 MBq/μg) plus SAHA vs. 111 In-DTPA-hEGF alone (11 ± 0.3 and 12 ± 0.7 vs. 9 ± 0.4 and 7 ± 0.3, respectively). 5-aza-2-deoxycytidine enhanced the DNA damage caused by IR and 111 In-DTPA-hEGF. Clonogenic survival was reduced in MDA-MB-468 and 231-H2N cells after IR (6 Gy) plus SAHA (1 μM) vs. IR alone (0.6% ± 0.01 and 0.3% ± 0.2 vs. 5.8% ± 0.2 and 2% ± 0.1, respectively) and after 111 In-DTPA-hEGF plus SAHA compared to 111 In-DTPA-hEGF alone (21% ± 0.4% and 19% ± 4.6 vs. 33% ± 2.3 and 32% ± 3.7). SAHA did not affect 111 In-DTPA-hEGF nuclear localization. Hypertonic treatment resulted in fewer γH2AX foci per cell after IR and 111 In-DTPA-hEGF compared to controls but did not significantly alter clonogenic
Täis- ja osasihitise kasutamisest eesti keelt teise keelena õppijate pilgu läbi / Raili Pool
Pool, Raili, 1969-
2006-01-01
Eesti keelt kõrgtasemel valdavate vene emakeelega üliõpilaste arvamustest ja põhjendustest eesti keele objektikäänete valiku kohta. Antakse ka lühiülevaade introspektiivsete meetodite võimalustest teise keele omandamise uurimisel
2008-01-01
Küsimusele vastavad Tallinna kristiine gümnaasiumi keemiaõpetaja Priit Ahte, Tallinna ühisgümnaasiumi eesti keele ja kirjanduse õpetaja Kristi Siirman, Kadrina keskkooli matemaatikaõpetaja Kaia Kauts ja Viimsi keskkooli inglise keele õpetaja Liis Prikk
Hasselblatti Eesti jõudmine eesti keelde / Cornelius Hasselblatt ; intervjueerinud Rein Veidemann
Hasselblatt, Cornelius, 1960-
2016-01-01
Intervjuu estofiilist keele- ja kirjandusteadlase ning tõlkija, Tartu ülikooli audoktori ja Eesti Teaduste Akadeemia välisliikme Cornelius Hasselblattiga tema neljast värskest eesti kirjandust ja kultuuri käsitlevast teosest, neist kolm eesti keeles
Tekstisisesed seosed eesti keele kui teise keele lugemistestis: mõõtmisvahendi valiidsus
Directory of Open Access Journals (Sweden)
Tiina Kikerpill
2013-10-01
Full Text Available Teksti mõistmine on keerukas protsess olenemata sellest, kas tegu on emakeeles või võõrkeeles lugemisega, sest see kätkeb endas samaaegset sõnade tuvastamist, tekstiga väljendatud otsese tähenduse tuletamist ja lugeja taustteadmiste abil teksti tõlgendamist. Üheks teksti mõistmise aspektiks on oskus ära tunda tekstis sisalduvaid sisulis-loogilisi ja leksikaalseid seoseid. Seega peaks lugemisoskuse arendamisel ja mõõtmisel pöörama tähelepanu ka tekstisisestele seostele. Võõrkeele lugemistestides kasutatakse nende seoste mõistmise kontrollimiseks erinevaid ülesandetüüpe, kuid nende tõhusust on vähe uuritud. Artiklis analüüsitakse kolme ülesandetüüpi – tekstilõikude järjestamist ning lausete ja tekstilõikude sobitamist lünkadesse. Keskendutakse nende valiidsusele, otsides vastust küsimustele, mil määral sõltub ülesannete edukas sooritamine tekstisiseste seoste mõistmisest ning missugune on ülesandetüübi mõju tekstisiseste seoste kasutamisele ülesande soorituses.
International Nuclear Information System (INIS)
Wang, Kun; Shi, Zongqian; Shi, Yuanjie; Bai, Jun; Wu, Jian; Jia, Shenli
2015-01-01
The equation of state, ionization equilibrium, and conductivity are the most important parameters for investigation of dense plasma. The equation of state is calculated with the non-ideal effects taken into consideration. The electron chemical potential and pressure, which are commonly used thermodynamic quantities, are calculated by the non-ideal free energy and compared with results of a semi-empirical equation of state based on Thomas-Fermi-Kirzhnits model. The lowering of ionization potential, which is a crucial factor in the calculation of non-ideal Saha equation, is settled according to the non-ideal free energy. The full coupled non-ideal Saha equation is applied to describe the ionization equilibrium of dense plasma. The conductivity calculated by the Lee-More-Desjarlais model combined with non-ideal Saha equation is compared with experimental data. It provides a possible approach to verify the accuracy of the equation of state and ionization equilibrium
2014-01-01
Otsitakse vastust küsimusele, kumb keel oli isa-poja Andreas ja Adrian Virginiuse tõlgitud Vana Testamendi sihtkeel, kas lõunaeesti või põhjaeesti keel ning kas Puhjas toimus midagi tõlketalgute taolist. Artikkel fikseerib uurimise hetkeseisu
Свобода по-русски / Анатолий Королев
Королев, Анатолий
2007-01-01
Tom Stoppardi triloogia vene ajaloost "The Coast of Utopia" ilmus vene keeles "Берег утопии" ja lavastatakse Moskvas Venemaa Akadeemilises Noorsooteatris. Teater korraldas esseevõistluse üliõpilastele "Vabadus vene keeles..."
Meetrika foneetikast / Ilse Lehiste
Lehiste, Ilse, 1922-2010
1995-01-01
Järg: nr. 9, lk. 596-603. Soome, eesti ja rootsi keele prosoodilise struktuuri ja nendes keeltes loodud luule meetrilise struktuuri omavahelistest suhetest; Leedu keele trohheilised mudelid; Rõhkude ajaline jaotus värsireas; Kokkuvõte ja järeldused
Tahaks eestlaseks saada / Erika Klaats
Klaats, Erika, 1954-
2000-01-01
Vt. ka Molodjozh Estonii : Subbota Sep/2 lk. 10. Venelased panevad lapse eesti kooli, kuid ei arvesta sellega, et võõras keeles õppides ei pruugi laps koolis edukalt edasi jõuda. Lisa: Eesti koolid, kus saab õppida vene keeles
Directory of Open Access Journals (Sweden)
Xiao-Tao He
2018-05-01
Full Text Available The easily developed morphine tolerance in bone cancer pain (BCP significantly hindered its clinical use. Increasing evidence suggests that histone deacetylases (HDACs regulate analgesic tolerance subsequent to continuous opioid exposure. However, whether HDACs contribute to morphine tolerance in the pathogenesis of BCP is still unknown. In the current study, we explored the possible engagement of HDACs in morphine tolerance during the pathogenesis of BCP. After intra-tibia tumor cell inoculation (TCI, we found that the increased expression of HDACs was negatively correlated with the decreased expression of MOR in the DRG following TCI. The paw withdrawal threshold (PWT and percentage maximum possible effects (MPEs decreased rapidly in TCI rats when morphine was used alone. In contrast, the concomitant use of SAHA and morphine significantly elevated the PWT and MPEs of TCI rats compared to morphine alone. Additionally, we found that SAHA administration significantly elevated MOR expression in the DRG of TCI rats with or without morphine treatment. Moreover, the TCI-induced increase in the co-expression of MOR and HDAC1 in neurons was significantly decreased after SAHA administration. These results suggest that HDACs are correlated with the downregulation of MOR in the DRG during the pathogenesis of BCP. Inhibition of HDACs using SAHA can be used to attenuate morphine tolerance in BCP.
Popperi ärkamine / Marju Lepajõe
Lepajõe, Marju, 1962-
2011-01-01
Arvustus: Popper, Karl. Avatud ühiskond ja selle vaenlased. [I, Platoni lummus]. Tallinn : Eesti Keele Sihtasutus, 2010 ; Popper, Karl. Avatud ühiskond ja selle vaenlased. II köide, Prohvetluse kõrgaeg: Hegel, Marx ja järellainetused. Tallinn : Eesti Keele Sihtasutus, 2011
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2003-01-01
Talvet, Jüri. ElegÍa Estonia y otros poemas = Eesti eleegia ja teisi luuletusi / Spanish transl. by the author and Albert L̉zaro Tinaut. Ciudad de València : Palmart, 2002 ; Ehlvest, Jüri. Hobune eikuskilt. Tallinn : Tänapäev, 2002 ; Raudam, Toomas. Saint-Prousti vastu. Tallinn : Eesti Keele Sihtasutus, 2002 ; Tode, Emil. Raadio. Tallinn : Eesti Keele Sihtasutus, 2002 ; Vene, Ilmar. Pahustumine ehk Uusaja olemus. Tallinn : Eesti Keele Sihtasutus, 2002 ; Annus, Epp. Kuidas kirjutada aega. Tallinn : Underi ja Tuglase Kirjanduskeskus, 2002 ; Lepik, Kalju. Valguse riie ei vanu. Kogutud luuletused 1938-1999 ; Barker, Matt. Waanenburgi tapatalgud. Tartu : EYS Veljesto, 2002 ; Kesküla, Kalev. Platoni riik. Tallinn : Tuum, 2002 ; Vahing, Vaino. Mängud ja kõnelused. Tallinn : Eesti Keele Sihtasutus, 2002 ; Tuulik, Jüri. Üksik lind mere kohal. Tallinn : Maalehe Raamat, 2002 ; Tätte, Jaan. Näidendid. Tallinn : Maalehe Raamat, 2002 ; Kareva, Doris. Mandragora. Tallinn : Huma, 2002
TUNA, FİKRET; SARIKAYA, MEHMET
2014-01-01
ÖZETSaha çalışması coğrafyanın en önemli öğretim metotlarından biridir ve coğrafya bilimini ve eğitimini saha çalışmasından ayrı düşünmek mümkün değildir. Ayrıca, saha çalışmaları, coğrafya eğitimine çok çeşitli katkılar sağlamaktadır. Bu çalışmanın temel amacı, coğrafya eğitimcilerine çeşitli fiziki coğrafya konularının öğretimi ile ilgili konularda faydalanabilecekleri örnek saha çalışması güzergâhı ve inceleme sahaları ve bunlarla ilgili bilgiler sunmaktır. Böylece, ihtiyaç duyan öğretmen ...
Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity
Directory of Open Access Journals (Sweden)
Chao-Hui Yang
2017-10-01
Full Text Available Previous studies have reported that modification of histones alters aminoglycoside-induced hair cell death and hearing loss. In this study, we investigated three FDA-approved histone deacetylase (HDAC inhibitors (vorinostat/SAHA, belinostat, and panobinostat as protectants against aminoglycoside-induced ototoxicity in murine cochlear explants and in vivo in both guinea pigs and CBA/J mice. Individually, all three HDAC inhibitors reduced gentamicin (GM-induced hair cell loss in a dose-dependent fashion in explants. In vivo, however, treatment with SAHA attenuated neither GM-induced hearing loss and hair cell loss in guinea pigs nor kanamycin (KM-induced hearing loss and hair cell loss in mice under chronic models of ototoxicity. These findings suggest that treatment with the HDAC inhibitor SAHA attenuates aminoglycoside-induced ototoxicity in an acute model, but not in chronic models, cautioning that one cannot rely solely on in vitro experiments to test the efficacy of otoprotectant compounds.
Piret Raua raamatud Saksamaal ja iPhone´is
2010-01-01
Piret Raua lasteraamat "Härra Linnu lugu" ilmus saksa keeles ; Piret Raua digitaalset pildiraamatut lastele "Emma roosad asjad" on võimalik kasutada Apple´i elektroonikatoodetes iPad, iPhone ja iPod (eesti, inglise ja jaapani keeles). Esitlus toimus 24. mail Lastekirjanduse Teabekeskuses
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2006-01-01
Arvustus: Krull, Hasso. Loomise mõnu ja kiri. Tallinn : Kultuurileht, 2006 ; Aleksejev, Tiit. Valge kuningriik. Tallinn : Varrak, 2006 ; Baturin, Nikolai. Sõnajalg kivis. Tallinn : Eesti Raamat, 2006 ; Nõu, Helga. Ood lastud rebasele. Tallinn : Eesti Keele Sihtasutus, 2006 ; Kaus, Jan. Tema. Tallinn : Tuum, 2006 ; Krull, Hasso. Talv. Tallinn : Tuum, 2006 ; Soomets, Triin. Väljas. Tallinn : Tuum, 2006 ; Kareva, Doris. Aja kuju. Tallinn : Verb, 2006 ; Vint, Toomas. Topeltvalguses. Tallinn : Eesti Keele Sihtasutus, 2005 ; Bristol, Piret. Sõud. Tallinn : Eesti Keele Sihtasutus, 2005 ; Valton, Arvo. Taltsutatud lammas : jutud. Tallinn : Kirjastuskeskus, 2005 ; Kivastik, Mart. Külmetava kunstniku portreed. Viinistu triloogia. Tartu : Väike Öömuusika, 2006
Ionization equilibrium and equation of state in the solar interior
International Nuclear Information System (INIS)
Rogers, F.J.
1984-01-01
Many-body formulations of the equations of state are restated as a set of Saha-like equations. It is shown that the resulting equations are unique and convergent. These equations are similar to the usual Saha equations to the order of the Debye-Huckel theory. Higher order corrections, however, require a more general formulation. It is demonstrated that the positive free energy resulting from the interaction of unscreened particles in high orbits depletes the occupation of these states, without the introduction of shifted energy levels
The ionisation equation in a relativistic gas
International Nuclear Information System (INIS)
Kichenassamy, S.; Krikorian, R.A.
1983-01-01
By deriving the relativistic form of the ionisation equation for a perfect gas it is shown that the usual Saha equation is valid to 3% for temperatures below one hundred million Kelvin. Beyond 10 9 K, the regular Saha equation is seriously incorrect and a relativistic distribution function for electrons must be taken into account. Approximate forms are derived when only the electrons are relativistic (appropriate up to 10 12 K) and also for the ultrarelativistic case (temperatures greater than 10 15 K). (author)
Krusell, Siim
2009-01-01
Statistikaameti poolt 2007. aastal läbi viidud täiskasvanute koolituse uuringu tulemustest. Artikli eesmärk on võrrelda 20-64-aastaste Eesti inimeste osalust täienduskoolituses selle järgi, kas nende emakeel on eesti keel või mõni muu keel
Quo vadis, emakeeleõpetus? / Raivo Juurak
Juurak, Raivo
2006-01-01
Ülevaade TLÜ-s toimunud Emakeeleõpetuse Infokeskuse teabepäevast, kus osalesid eesti keele ja kirjanduse õpetajad ning TLÜ keele- ja kirjandusteadlased. Lähemalt Rocca al Mare õpetaja J. Vaiksoo, TLÜ dotsendi K. Kerge ja Haridus- ja Teadusministeeriumi nõuniku J. Valge sõnavõttudest
Keele salaelu / Kristiina Ross
Ross, Kristiina, 1955-
2004-01-01
Vana Testamendi eestikeelsest tõlkest, mille tegid ajavahemikul 1687-1690 isa ja poeg Andreas ja Adrian Virginius. Rmt.: Esimene Moosese raamat. Iiobi raamat / tõlkinud 1687-1690 Andreas ja Adrian Virginius. Tallinn, 2003
Karl Ristikivi prantsuse keeles
2003-01-01
29. ja 30. mail Tallinna Kirjanike Majas ja 31. mail Tartu Kirjanduse Majas esinevad näitlejad Ene Rämmeld ja Claude Merlin Karl Ristikivi luulekavaga "Inimese teekond" (tõlkija Tarah Montbélialtz). Vt. ka Looming, 2003, nr. 6, lk. 953
Vaimude keel / Anzori Barkalaja
Barkalaja, Anzori, 1968-
2001-01-01
Šamanismist, ka šamanismi seosest kunstiga, eriti performance'iga. 11.-17. VIII Viljandi Kultuurikolledžis Rahvusvahelise Šamanismiuurimise Ühingu VI konverents, põhiteemadeks "Uued lähenemisviisid Põhja šamanismile" ja "Šamanism valdkondadevahelisel taustal".
2007-01-01
2006. aasta lõpus ilmus India kirjastuse Sarup & Sons vahendusel Jüri Talveti koostatud ingliskeelne raamat eesti luulest "On the way home. An anthology of contemporary estonian poetry", mis koondab luulet Andres Ehinilt, Jaan Kaplinskilt, Hasso Krullilt, Ene Mihkelsonilt, Paul-Eerik Rummolt, Hando Runnelilt, Triin Soometsalt, Jüri Talvetilt, Mari Vallisoolt ja Juhan Viidingult
2008-01-01
Küsimusele vastavad Tallinna Mustamäe Gümnaasiumi eesti keele õpetaja Helin Puksand, Microsofti esindaja Peter Fifka, riigikogu liige Marek Strandberg, Pelgulinna Gümnaasiumi arvutiõpetaja Birgy Lorenz, Tallinna Ülikooli haridustehnoloogia keskuse juhataja Mart Laanpere, teleajakirjanik Andres Raid ja Kose Gümnaasiumi saksa keele õpetaja Astrid Sildnik
Marie Underile pühendatakse konverents
2008-01-01
Tartus Eesti Kirjandusmuuseumis toimuvast Marie Underi 125. sünniaastapäevale pühendatud konverentsist ja näitusest "Kunsti Marie Underi kodust". Vt. ka Keel ja Kirjandus, nr. 4, 2008, lk. 317; Looming, nr. 4, 2008, lk. 635; Keel ja Kirjandus, nr. 7, lk. 570-572
EILC - Erasmus Intensive Language Course / Eve Müür
Müür, Eve
2009-01-01
Erasmuse üliõpilastel, kes sõidavad õppima või praktikale riiki, mille keel on üks vähemkasutatud ja vähemõpetatud keeltest Euroopas, on võimalus osaleda kuni 6 nädalastel intensiivkeelekursustel. Eesti keele õppe korraldusest välisüliõpilastele EBS-is
TYTÖNTYLLERÖ JA POJANJOLPPI SUOMESSA JA VIROSSA
Directory of Open Access Journals (Sweden)
Marja Leinonen
2010-01-01
Full Text Available Artikkel käsitleb deskriptiivset (koloratiivset nominaaltarindit eesti ja soome keeles, mille süntaktiline sõltuvussuhe on normaalsega vastupidine: atributiivne genitiiv väljendab referendi denotatiivset tähendust ja põhisõna kirjeldab seda. Kirjeldusega on tavaliselt seotud pejoratiivsed, hellitlevad või muul viisil hinnangulised nüansid. Artiklis tutvustatakse kõigepealt soome keele vastavaid uurimusi, seejärel selle artikli tarbeks kogutud materjali ning selle võrdlust indoeuroopa keelte süntaktiliselt ja semantiliselt sarnaste tarinditega. Lisaks tutvustatakse soome ja eesti keeles esinevat deskriptiivset verbaaltarindit, milles põhiverbi tähendust kannab infinitiiv, kusjuures deskriptiivverb (mida vahel nimetatakse ka ideofooniks on finiitses vormis.
Determination of particle concentrations in multitemperature plasmas
International Nuclear Information System (INIS)
Richley, E.; Tuma, D.T.
1982-01-01
The use of the multitemperature Saha equation (MSE) of Prigogine 1 and Patapov 2 for calculating particle concentrations in plasmas is shown to be an invalid procedure. Errors greater than one order of magnitude in the electron density in high-pressure argon and nitrogen electric arc plasmas can be easily incurred by using the multitemperature Saha equation. The alternative kinetic method for calculating concentrations is shown to be based on firm concepts. Simpliying procedures and computational techniques for calculating concentrations with the kinetic method are illustrated with examples
Directory of Open Access Journals (Sweden)
Luca Vernich
2017-05-01
Full Text Available Using different experimental tasks, researchers have pointed to a possible correlation between grammatical gender and classification behaviour. Such effects, however, have been found comparing speakers of a relatively small set of languages. Therefore, it’s not clear whether evidence gathered can be generalized and extended to languages that are typologically different from those studied so far. To the best of our knowledge, Baltic and Finno-Ugric languages have never been examined in this respect. While most previous studies have used English as an example of gender-free languages, we chose Estonian because – contrary to English and like all Finno-Ugric languages – it does not use gendered pronouns (‘he’ vs. ‘she’ and is therefore more suitable as a baseline. We chose Lithuanian because the gender system of Baltic languages is interestingly different from the system of Romance and German languages tested so far. Taken together, our results support and extend previous findings and suggest that they are not restricted to a small group of languages. "Grammatiline sugu objektide kategoriseerimise mõjutajana: eesti, itaalia ja leedu keele võrdlev uurimus" Eri tüüpi eksperimente kasutades on uurijad osutanud grammatilise soo ja objektide klassifitseerimise võimalikele seostele. Senised tulemused on saadud siiski suhteliselt väheste keelte andmete võrdlemisel. Seetõttu ei ole teada, kas need järeldused on üldistatavad ka nendele keeltele, mille struktuur erineb siiani uuritud keeltest. Probleemi uurimiseks laiendasime vaadeldavate keelte hulka ja tegime grammatilise soo ja objektide kategoriseerimise seoste katse läbi balti ja soome-ugri keelte hulka kuuvate keeltega, mida ei ole kõnealusest vaatenurgast uuritud. Enamik seniseid uuringuid on seadnud nn lähtepunktiks ehk grammatilise soota keeleks inglise keele. Siinses uuringus valisime aga selliseks lähtepunktiks hoopis eesti keele, kus erinevalt inglise keelest ei ole ka
2015-01-01
Eraalgatuslik Wiedemanni fond toetab nii eesti keele õpilasuurimusi kui ka ülikooliõpinguid, sh magistri- ja doktoriõpet. Küsimustele vastavad Wiedemanni fondi 2015. aasta stipendiaadid, eesti keele ja kirjanduse õpetajad Piret Järvela Tallinna reaalkoolist, Liivi Heinla Kadrina keskkoolist ja Aili Kiin Viljandi gümnaasiumist. Küsitles Külliki Kask
Pan-Balti bränding - müüt või tegelikkus? / Joel Volkov
Volkov, Joel, 1972-
2006-01-01
Brändil pole kodumaad, on keel ja päritolumaa. Lokaalsed brändid valivad suhtlemiseks kohalikega nende kodukeele, globaalsed brändid harilikult inglise keele. Üks suuremaid ja tugevamaid lokaalsest süsteemist kasvanud Pan-Balti brände on Hansapank. Lisa: Sulev Vedler. Hansast võib saada Swedbank
Rahvus ja rahvuslus eesti tänases ajakirjanduses / Andres Ehin
Ehin, Andres, 1940-2011
1996-01-01
Sisu : 'Keel ja Kirjandus', 1996, nr. 10 (Paul Kokla art. 'Eesti keele ja kirjanduse väljavaated'); 'Luup', 1996, 28. okt. ('Lev Gumiljov : Eestlased on saavutanud praktilise surematuse'); 'Kadrioru Teataja' IV/1996; (Juri Surovtsevi art. 'Kordonite ja diviidideta') 'Akadeemia', 1996, nr. 10 (Jüri Alliku art. 'Hämmastav hüpotees teadvuse kohta')
Short outlines of books by Estonian authors / Janika Kronberg and Rutt Hinrikus
Kronberg, Janika, 1963-
2010-01-01
Arvustus: Käsper, Kalle. Buridanid. I-V. Tallinn : Eesti Keele Sihtasutus, 2005-2010 ; Kivastik, Mart. Eesti asjad. Tartu : Kaks Musketäri, 2010 ; Kangro, Maarja. Ahvid ja solidaarsus. Tallinn : Eesti keele Sihtasutus, 2010 ; Põder, Rein. Unustatud. Tallinn : Eesti Raamat, 2010 ; Kesküla, Kalev. Elu sumedusest. Tallinn : Tuum, 2009 ; Pilv, Aare. Ramadaan. Tallinn : Tuum, 2010
Directory of Open Access Journals (Sweden)
Yeimy Cifuentes
Full Text Available ABSTRACT A new species of Pamphobeteus Pocock, 1901, is described from the Colombian Andes, Medellín, Antioquia. The biochemistry and molecular characteristics of the venom of this new species (previously identified as Pamphobeteus aff. nigricolor has been already described. A detailed taxonomic study, comparing this species with holotypes and additional material of Pamphobeteus species, allowed us to recognize it as new, and to describe it here as Pamphobeteus verdolaga sp. nov. The male of P. verdolaga sp. nov. is distinguished by the palpal bulb with broad embolus, poorly developed apical keel (A, prolateral inferior keel (PI and prolateral accessory keel (PAc present but poorly developed, and retrolateral keel (R of similar length as A. Females are distinguished by the morphology of spermatheca with a wide base and very short oval seminal receptacles, which are curved toward the center. This is the thirteenth species described in Pamphobeteus and the sixth species reported from Colombia. The species description is complemented by a molecular characterization of a partial CO1 sequence.
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2004-01-01
Tutvustus: Baturin, Nikolai. Kentaur. Tallinn : Eesti Raamat, 2003 ; Kaplinski, Jaan. Isale. Tallinn : Varrak, 2003 ; Jaks, Ilmar. Pimedus. Tartu : Ilmamaa, 2003 ; Ivask, Ivar. Tähtede tähendust tunda. Tartu : Ilmamaa, 2003 ; Vint, Toomas. Minu abielu prostituudiga. Tallinn : Eesti Keele Sihtasutus, 2003 ; Ehin, Kristiina. Luigeluulinn. Tallinn : Huma, 2004 ; Kivisildnik. Päike, mida sa õhtul teed? Tallinn : Perioodika, 2003 ; Kivisildnik. Rahvuseepos Kalevipoeg ehk armastus. Tallinn : Tuum, 2003 ; Veidemann, Rein. Lastekodu. Tallinn : Eesti Keele Sihtasutus, 2003 ; Park, Eeva. Lõks lõpmatuses. Tallinn : Tänapäev, 2003 ; Traat, Mats. Islandi suvi. Tartu : Ilmamaa, 2003 ; Kauksi Ülle. Uibu. Tartu : Kauksi Ülle Mänedsment, 2003 ; Kross, Jaan. Kallid kaasteelised. Tallinn : Eesti Keele Sihtasutus, 2003 ; Undusk, Jaan. Quevedo. Tallinn : Perioodika, 2003
Directory of Open Access Journals (Sweden)
Nobuyoshi Fukumitsu
2018-01-01
Full Text Available Background. Histone deacetylases (HDACs regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose. We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18F]fluoroacetamido-1-hexanoicanilide ([18F]FAHA as a positron emission tomography (PET imaging agent for HDAC IIa. Materials and Methods. [18F]FAHA and [18F]fluoro-2-deoxy-2-D-glucose ([18F]FDG PET studies were done in 24 mice on 2 consecutive days and again 1 week later. The mice were divided into three groups according to drug administration between the first and second imaging sessions (Group A: cisplatin 2 mg/kg, twice; Group B: cisplatin 4 mg/kg, twice; Group C: cisplatin 4 mg/kg, twice, and SAHA 300 mg/kg pretreatment, 4 times. Results. The Ki value of [18F]FAHA was increased and the percentage of injected dose/tissue g (% ID/g of [18F]FDG was decreased in the brains of animals in Groups A and B. The Ki value of [18F]FAHA and % ID/g of [18F]FDG were not significantly different in Group C. Conclusions. [18F]FAHA PET clearly showed increased HDAC activity suggestive of cisplatin neurotoxicity in vivo, which was blocked by SAHA pretreatment.
Hispaania suursaadiku visiit / Reet Kääni
Kääni, Reet
2001-01-01
13.02.2001 külastas Tallinna Pedagoogikaülikooli Helsingis resideeruv Hispaania suursaadik Fernando Carderera Soleri ja saatkonna I sekretär Tereza Lizaranzu Perinat. Külaliste visiidi üheks eesmärgiks oli uurida võimalusi hispaania keele ja kultuuri õpetamiseks TPÜs. Dekaan Heli Mattisen oli ette valmistanud omapoolse ettepaneku hispaania keele kõrvalaine avamiseks 1.09.2001
Kas olete mõelnud välismaal õpetamisele? / Edward Kess, Helen Oppar, Sergei Ptšjolkin ... [jt.
2011-01-01
Küsimusele vastavad Tallinna 37. keskkooli eesti keele ja kirjanduse õpetaja Edward Kess, Varstu keskkooli loodusainete õpetaja Helen Oppar, Tallinna Mustjõe gümnaasiumi füüsikaõpetaja Sergei Ptšjolkin, Sürgavere põhikooli muusikaõpetaja Helve Tähis, Nõo reaalgümnaasiumi inglise keele õpetaja Tiina Tuuling ning Rahumäe põhikooli matemaatikaõpetaja Kadri Hiob
HDAC inhibitor-loaded bone cement for advanced local treatment of osteosarcoma and chondrosarcoma.
Tonak, Marcus; Becker, Marc; Graf, Claudine; Eckhard, Lukas; Theobald, Matthias; Rommens, Pol-Maria; Wehler, Thomas C; Proschek, Dirk
2014-11-01
The treatment of osteosarcoma, especially wide resection, is challenging. An additional local drug therapy after resection using anti-neoplastic bone cement (Polymethylmethacrylate (PMMA)) could help improve the outcome of therapy. In this study, we evaluated the effects of PMMA loaded with valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) on the cell activity of a SaOs-2 cell culture, as well as the elution rate of the drugs out of the bone cement. In our experiments, we used the SaOs-2 osteosarcoma and the SW1353 chondrosarcoma cell line. Bone cement clots (5 g) were prepared and loaded with different drug concentrations of VPA (25 mg and 50 mg) and SAHA (1 mg, 2.5 mg and 5 mg). Two control groups were established, one with a native cement clot, the other with human mesenchymal stem cells, in order to evaluate toxicity on non tumor-cells. Cell activity was measured using an Alamar Blue assay on days 1, 2, 3, 4 and 7. The cement clots were additionally examined in a material testing unit for biomechanical and structural changes. Tumor cells showed a significant and complete reduction of activity under therapy with VPA and SAHA. Drug release of VPA was extensive between days 0 and 3 and decreased progressively to day 7. Cumulative drug concentration in the medium continuously increased. Biomechanical testing of the cement clots showed no differences in stability and architecture compared to the control group. SaOs-2 and SW1353 cells with medium from native cement clots without drug therapy presented a cell activity of 100% in all groups and during all measurements. Human mesenchymal stem cells were not significantly affected during therapy with VPA and low concentrations of SAHA. In contrast, cell activity of human mesenchymal stem cells was significantly reduced under therapy with higher concentrations of SAHA, with an approximately linear decrease between days 0-3 and a rapidly decreasing activity between days 4-7. A local cytotoxic therapy in the
Directory of Open Access Journals (Sweden)
Anna Wawruszak
Full Text Available Histone deacetylase inhibitors (HDIs are promising anticancer drugs, which inhibit proliferation of a wide variety of cancer cells including breast carcinoma cells. In the present study, we investigated the influence of valproic acid (VPA and suberoylanilide hydroxamic acid (SAHA, vorinostat, alone or in combination with cisplatin (CDDP on proliferation, induction of apoptosis and cell cycle progression in MCF7, T47D and MDA-MB-231 human breast carcinoma cell lines. The type of interaction between HDIs and CDDP was determined by an isobolographic analysis. The isobolographic analysis is a very precise and rigorous pharmacodynamic method, to determine the presence of synergism, addition or antagonism between different drugs with using variety of fixed dose ratios. Our experiments show that the combinations of CDDP with SAHA or VPA at a fixed-ratio of 1:1 exerted additive interaction in the viability of MCF7 cells, while in T47D cells there was a tendency to synergy. In contrast, sub-additive (antagonistic interaction was observed for the combination of CDDP with VPA in MDA-MB-231 "triple-negative" (i.e. estrogen receptor negative, progesterone receptor negative, and HER-2 negative human breast cancer cells, whereas combination of CDDP with SAHA in the same MDA-MB-231 cell line yielded additive interaction. Additionally, combined HDIs/CDDP treatment resulted in increase in apoptosis and cell cycle arrest in all tested breast cancer cell lines in comparison with a single therapy. In conclusion, the additive interaction of CDDP with SAHA or VPA suggests that HDIs could be combined with CDDP in order to optimize treatment regimen in some human breast cancers.
Inhibition of SRC-3 enhances sensitivity of human cancer cells to histone deacetylase inhibitors
Energy Technology Data Exchange (ETDEWEB)
Zou, Zhengzhi, E-mail: zouzhengzhi@m.scnu.edu.cn [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510000 (China); Luo, Xiaoyong [Department of Oncology, The Affiliated Luoyang Central Hospital of Zhengzhou University, Luoyang 471000 (China); Nie, Peipei [KingMed Diagnostics and KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 510000 (China); Wu, Baoyan; Zhang, Tao; Wei, Yanchun [MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510000 (China); Wang, Wenyi [Xiamen Cancer Center, Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China); Geng, Guojun; Jiang, Jie [Xiamen Cancer Center, Department of Thoracic Surgery, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China); Mi, Yanjun, E-mail: myjgj_77@163.com [Xiamen Cancer Center, Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen 361000 (China)
2016-09-09
SRC-3 is widely expressed in multiple tumor types and involved in cancer cell proliferation and apoptosis. Histone deacetylase (HDAC) inhibitors are promising antitumor drugs. However, the poor efficacy of HDAC inhibitors in solid tumors has restricted its further clinical application. Here, we reported the novel finding that depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors (SAHA and romidepsin). In contrast, overexpression of SRC-3 decreased SAHA-induced cancer cell apoptosis. Furthermore, we found that SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. The combination of bufalin and SAHA was particular efficient in attenuating AKT activation and reducing Bcl-2 levels. Taken together, these accumulating data might guide development of new breast and lung cancer therapies. - Highlights: • Depletion of SRC-3 enhanced sensitivity of breast and lung cancer cells to HDAC inhibitors. • Overexpression of SRC-3 enhanced cancer cell resistance to HDAC inhibitors. • SRC-3 inhibitor bufalin increased cancer cell apoptosis induced by HDAC inhibitors. • Bufalin synergized with HDAC inhibitor attenuated AKT activation and reduced Bcl-2 levels in human cancer cell.
Получая образование в Эстонии, открываем для себя мир / Рейли Аргус
Аргус, Рейли, 1967-
2011-01-01
Tallinna Ülikoolis õpetatavast bakalaureusetaseme erialast eesti keel võõrkeelena ja eesti kultuur. Magistritasemel saab õppida eesti keele kui võõrkeele õpetajaks. Selle eriala Ida-Virumaalt pärit vilistlased ja üliõpilased Anna Šiškova, Maaja Orlova, Deniss Jegorov, Anna Pirk, Jekaterina Ozernova ja Anastassia Šmõreitšik selgitavad eriala valimise, õppimise, Tallinnas kohanemise ja enda edasise elu kohta.
Meie enda kodune kõrgharidus ja järjest avaram maailm / Reili Argus
Argus, Reili, 1967-
2011-01-01
Tallinna Ülikoolis õpetatavast bakalaureusetaseme erialast eesti keel võõrkeelena ja eesti kultuur. Magistritasemel saab õppida eesti keele kui võõrkeele õpetajaks. Selle eriala Ida-Virumaalt pärit vilistlased ja üliõpilased Anna Šiškova, Maaja Orlova, Deniss Jegorov, Anna Pirk, Jekaterina Ozernova ja Anastassia Šmõreitšik selgitavad eriala valimise, õppimise, Tallinnas kohanemise ja enda edasise elu kohta
Romanov, Vladimir
2004-01-01
Sisu: "Miks, kägu, sa mäe peal seal kukkumas käid ..." ; "Pikk on tee. Küla taga, kus aas ...." ; "Milleks sulle mu armastust vaja on veel ..." ; "Terve päev nii möödub üha ..." ; "Väike tütarlaps mõnusalt suplemas jões ..." ; Maasikad ; Mesilaste keel. Eluloolisi andmeid autori kohta lk. 371. Luuletused paralleelselt udmurdi ja eesti keeles
Omamoodi ime - ilmunud on eesti-läti sõnaraamat / Lembit Vaba
Vaba, Lembit 1945-
2015-01-01
Arvustus: Igauņu-latviešu vārdnīca / Latviešu valodas aģentūra ; sastādītāji: Valts Ernštreits, Marika Muzikante, Maima Grīnberga = Eesti-läti sõnaraamat / Läti keele agentuur ; koostajad: Valts Ernštreits, Marika Muzikante, Maima Grīnberga. Rīga ; Tallinn : Eesti Keele Sihtasutus, 2015
Kaks soome-ugri keeleõppeprojekti
Ivar Sinimets
2010-01-01
There is a traditionally deep interest between Estonia, Finland and Hungary based on linguistic relations. The paper describes projects survival.hu and Te-Le-Hu, the aim of the projects was competence building of teachers of Hungarian working in liberal adult educational institutions. Survival.hu was a communicative beginners teaching package of Hungarian language for Finns. The learning and teaching material (textbooks, teachers' books, phrase book, 2 CD and short course for television focus...
Eesti keele partiklid / Leelo Keevallik
Keevallik, Leelo
2004-01-01
igapäevasest kõnekeelest, mustritest suhtlemises, verbivormide arengust ja muutumisest - see on teaduslikuks uurimisobjektiks ja väitekirja "From Interaction to Grammar : Estonian Finite Verb Forms in Conversation" aluseks
2004-01-01
Dagmar Normeti lasteraamatu "Une-Mati, Päris-Mati ja Tups" tõlget vene keelde (tõlkijad Irina Belobrovtseva ja Vitali Belobrovtsev; ill. Siima Shkop) esitletakse täna Kirjanike Liidu saalis; vt. ka Postimees, 19. märts, lk. 14
Selges eesti keeles / Jaanus Kulli
Kulli, Jaanus, 1955-
2000-01-01
Lühimängufilm "Armas tuss 50 aastat hiljem" : režissöör René Vilbre : peaosades Lembit Eelmäe ja Herta Elviste. Filmi režissöör R. Vilbre ja produtsent A. Talvik tööst filmiga ja eelseisvast esilinastusest Pimedate Ööde Filmifestivalil
Kaks soome-ugri keeleõppeprojekti
Directory of Open Access Journals (Sweden)
Ivar Sinimets
2010-10-01
Full Text Available There is a traditionally deep interest between Estonia, Finland and Hungary based on linguistic relations. The paper describes projects survival.hu and Te-Le-Hu, the aim of the projects was competence building of teachers of Hungarian working in liberal adult educational institutions. Survival.hu was a communicative beginners teaching package of Hungarian language for Finns. The learning and teaching material (textbooks, teachers' books, phrase book, 2 CD and short course for television focusing on tourism and culture has been warmly welcomed by learners and teachers, the materials have been used in Estonia too. During the Te-Le-Hu project there were held teachers' seminars in Helsinki, in Budapest and seminar for leaners in Kasmu. The benefit of the projects was sharing of good practices, creating new contacts and an European network for teachers of Hungarian for participating countries.
Tomson, Ela, 1945-
2004-01-01
Ilmunud ka: Võrumaa Teataja, 9. sept. 2004, lk. 2; Lõunaleht, 9. sept. 2004, lk. 2; Meie Maa, 9. sept. 2004, lk. 2; Põhjarannik, 9. sept. 2004, lk. 2; Severnoje Poberezhje, 9. sept. 2004, lk. 2; Sakala, 10. sept. 2004, lk. 2; Pärnu Postimees, 10. sept. 2004, lk. 11; Hiiumaa, 11. sept. 2004, lk. 2; Koit, 11. sept. 2004, lk. 6; Vali Uudised, 15. sept. 2004, lk. 2; Lääne Elu, 21. sept. 2004, lk. 2. Autor arutleb Lihula monumendi teisaldamise teemal ning toetab Toomas Hendrik Ilvese ideed rahvusvahelise komisjoni moodustamiseks
Kellele kuulub keel? / Maarja Siiner
Siiner, Maarja
2012-01-01
Arvustus: Kadri Koreinik. Language ideologies in the contemporary Estonian public: with a focus on South Estonian. Tartu : Tartu University Press, 2011.(Dissertationes sociologicae Universitatis Tartuensis ; 5)
Telenovela'de keel / Kaisa Karu
Karu, Kaisa
2007-01-01
Kolumbia telenovela "Luna" peategelasi kehastavad venetsueelalane Gaby Espino ja peruulane Christian Meier. Üheks raskuseks töö juures on erinevate aktsentide ühtlustamise vajadus. Lühidalt ka näitlejate varasemast karjäärist
Tomberg, Jaak, 1980-
2006-01-01
Autorid on lähtepunktiks võtnud Jaan Unduski teose "Maagiline müstiline keel" ja osutavad sellele, kuidas keele ja vaikuse vahelise suhte kaudu on võimalik teadvustada reaalsuse ja virtuaalsuse vahekorda ning transtsedentaalse empirismi kirjeldused Gilles Deleuze'i raamatust "Logique du sens" (1973) ja Slavoj Zhizheki raamatust "Organs Without Bodies" (2004). Eesmärgiks on rajada esmane teoreetiline aluspõhi uueks vaatenurgaks kultuuri- ja fiktsiooniteoreetilistele põhiküsimustele
"Leonardo da Vinci" projekt kutsehariduses / Piret Kärtner
Kärtner, Piret
2001-01-01
14.-25. mainì2001 viibisid seitse Eesti kutsekoolide inglise keele õpetajat ja kaks Riikliku Eksami- ja Kvalifikatsioonikeskuse esindajat Leonardo da Vinci projekti raames Rootsis Malmös, et tutvuda rootslaste ja hollandlaste koostöös välja töötatud programmi TENTEC - Teaching English for Technical Purposes rakendusvõimalustega, innovatiivsete võõrkeeleõppemeetoditega, eriala- ja keeleõppe integreeritud õpetusega, õppematerjalidega, mis põhinevad IT võimalustel
Morphofunctional Traits and Pollination Mechanisms of Coronilla emerus L. Flowers (Fabaceae)
Aronne, Giovanna; Giovanetti, Manuela; De Micco, Veronica
2012-01-01
It is accepted that the papilionaceous corolla of the Fabaceae evolved under the selective pressure of bee pollinators. Morphology and function of different parts of Coronilla emerus L. flowers were related to their role in the pollination mechanism. The corolla has a vexillum with red nectar lines, a keel hiding stamens and pistil, and two wing petals fasten to the keel with two notched folds. Pollinators land on the complex of keel and wings, trigger the protrusion of pollen and finally of the stigma from the keel tip. Data on pollen viability and stigma receptivity prove that flowers are proterandrous. The results of hand-pollination experiments confirmed that insects are fundamental to set seed. Interaction with pollinators allows not only the transport of pollen but also the rupture of the stigmatic cuticle, necessary to achieve both allogamy and autogamy. Field observations showed that Hymenoptera, Lepidoptera, and Diptera visited the flowers. Only some of the Hymenoptera landed on the flowers from the front and elicited pollination mechanisms. Most of the insects sucked the nectar from the back without any pollen transfer. Finally, morphological and functional characteristics of C. emerus flowers are discussed in terms of floral larceny and reduction in pollination efficiency. PMID:22666114
MIDA TEEB TEGEMA-VERB HOIDJAKEELES
Directory of Open Access Journals (Sweden)
Reili Argus
2010-01-01
Full Text Available Esimese keele omandamist mõjutab lapsele suunatud keel ehk hoidjakeel, mis pakub lapsele loomuliku keele sellise statistilise struktuuri, kus tõuseb esile mingi keelesüsteemiosa kõige sagedasem, üldisem, prototüüpsem, kesksem ning kõige lihtsam element. Hoidjakeeles esineb teistest verbidest sagedamini verbi tegema. Selle verbi ühendite hulk ja laad muutub lapse kasvades. Üldjoontes võib tegema-verbi tugiverbi konstruktsioonid lapsele suunatud kõnes jaotada kolme suuremasse rühma: kõige enam esineb selliseid ühendeid, kus tegema verbiga esineb koos mõni onomatopoeetiline sõna; tegema-verbi ja adverbi või adjektiivi ühendeid, millega rõhutatakse teelisust,leidub mõnevõrra vähem ning umbes neljandiku moodustavad tegema-verbi ja noomeni ühendid. Püsiühendite ja rutiniseerunud mallide suur hulk (moodustavad lapsele suunatud kõnes tegema-verbi konstruktsioonidest peaaegu poole annab alust oletada, et lapsega kõneleja eelistab kasutada n-ö valmis kujul keeletükke. Kuigi tegema-verbil on oma roll nii leksika kui ka süntaksi omandamises, ilmneb tema olulisus kõige selgemalt vormimoodustuse omandamise kontekstis: just sellest verbist esineb lapsele suunatud kõnes kõige enam eri vorme ning just see on üks kahest varakult omandatud vormimoodustusega verbe ka lapse kõnes.
Directory of Open Access Journals (Sweden)
Dominik Jaskierniak
2015-06-01
Full Text Available Managers of forested water supply catchments require efficient and accurate methods to quantify changes in forest water use due to changes in forest structure and density after disturbance. Using Light Detection and Ranging (LiDAR data with as few as 0.9 pulses m−2, we applied a local maximum filtering (LMF method and normalised cut (NCut algorithm to predict stocking density (SDen of a 69-year-old Eucalyptus regnans forest comprising 251 plots with resolution of the order of 0.04 ha. Using the NCut method we predicted basal area (BAHa per hectare and sapwood area (SAHa per hectare, a well-established proxy for transpiration. Sapwood area was also indirectly estimated with allometric relationships dependent on LiDAR derived SDen and BAHa using a computationally efficient procedure. The individual tree detection (ITD rates for the LMF and NCut methods respectively had 72% and 68% of stems correctly identified, 25% and 20% of stems missed, and 2% and 12% of stems over-segmented. The significantly higher computational requirement of the NCut algorithm makes the LMF method more suitable for predicting SDen across large forested areas. Using NCut derived ITD segments, observed versus predicted stand BAHa had R2 ranging from 0.70 to 0.98 across six catchments, whereas a generalised parsimonious model applied to all sites used the portion of hits greater than 37 m in height (PH37 to explain 68% of BAHa. For extrapolating one ha resolution SAHa estimates across large forested catchments, we found that directly relating SAHa to NCut derived LiDAR indices (R2 = 0.56 was slightly more accurate but computationally more demanding than indirect estimates of SAHa using allometric relationships consisting of BAHa (R2 = 0.50 or a sapwood perimeter index, defined as (BAHaSDen½ (R2 = 0.48.
Directory of Open Access Journals (Sweden)
Bérengère Vire
Full Text Available Histone deacetylase inhibitors (HDACi have demonstrated promising therapeutic potential in clinical trials for hematological malignancies. HDACi, such as SAHA/Vorinostat, Trichostatin A, and MS-275 were found to induce apoptosis of leukemic blasts through activation of the death receptor pathway and transcriptional induction of the Tumor Necrosis Factor (TNF-related pro-apoptotic family members, TRAIL and FasL. The impact of HDACi on TNF-related costimulatory molecules such as 4-1BB ligand (4-1BBL/TNFSF9 is however not known. Following exposure to SAHA/Vorinostat, Trichostatin A, and MS-275, transcript levels were determined by real time PCR in Jurkat, Raji and U937 cells. Treatment with HDACi up-regulated TNFSF9 gene expression in the three leukemia cell lines, yet to different extend and with distinct kinetics, which did not require de novo protein synthesis and was not associated with DNAse I hypersensitive chromatin remodeling. Transcriptional activity of TNFSF9 promoter-luciferase constructs was induced up to 12 fold by HDACi, and implication of Sp1/Sp3 transcription factors binding to functional GC-box elements was evidenced by reporter gene assays, site-directed mutagenesis, and electrophoretic mobility shift assays. Functionality of modulated target genes was assessed in allogeneic mixed leukocyte reaction experiments. MS-275- and to a lesser extent Trichostatin A- and SAHA-treated Raji cells significantly up regulated T lymphocytes proliferation which was reduced by about 50% by a 4-1BB blocking recombinant protein, while MS-275- but neither Trichostatin A- nor SAHA-treated cells up-regulated IFNgamma secretion by T lymphocytes. Our results identify 4-1BBL/4-1BB as a downstream target of HDACi, especially of MS-275 anti-leukemia action in vitro. Thus, HDACi such as MS-275 displaying dual TNF-dependent proapoptotic and costimulatory activities might be favored for inclusion in HDACi-based anti-cancer therapeutic strategies.
Thermal equilibrium criteria in a nitrogen plasma
International Nuclear Information System (INIS)
Cilliers, W.A.; Hey, J.D.; Rash, J.P.S.
1975-01-01
A method for obtaining the lower electron density limit for LTE in a nitrogen plasma is described, whereby the experimentally determined ratio of the collisional-radiative ionization and recombination coefficients (S/α) is compared with the corresponding LTE value (Saha ratio). It is argued that if the electron density is increased from values of about 10 16 cm -3 , S/α should tend to the Saha ratio as LTE is approached For NII and NIII spectral lines, this is found to happen at an electron density of a few times 10 16 cm -3 when the electron temperature is about 3 eV, in good agreement with the LTE criterion of Griem. (author)
Improvements to the RADIOM non-LTE model
Busquet, M.; Colombant, D.; Klapisch, M.; Fyfe, D.; Gardner, J.
2009-12-01
In 1993, we proposed the RADIOM model [M. Busquet, Phys. Fluids 85 (1993) 4191] where an ionization temperature T z is used to derive non-LTE properties from LTE data. T z is obtained from an "extended Saha equation" where unbalanced transitions, like radiative decay, give the non-LTE behavior. Since then, major improvements have been made. T z has been shown to be more than a heuristic value, but describes the actual distribution of excited and ionized states and can be understood as an "effective temperature". Therefore we complement the extended Saha equation by introducing explicitly the auto-ionization/dielectronic capture. Also we use the SCROLL model to benchmark the computed values of T z.
Euroopa keelemapi esimene Eesti mudel / Tõnu Tender
Tender, Tõnu, 1965-
2008-01-01
Väljaanne: Euroopa keelemapp : 12-16 aastastele õpilastele = European language portfolio : for learners aged 12 to 16 = Portfolio Européen des Langues : pour les élèves de 12 à 16 ans. [Tartu] : Haridus- ja Teadusministeerium ; [Tallinn] : Eesti Keele Sihtasutus, [2007]. Euroopa keelemapp on vahend keeleõppe kavandamiseks, edusammude kirjeldamiseks ja tulemuste jäädvustamiseks. Keelemapi kirjeldus, Euroopa keelemapi Eesti variandi väljatöötamisest, Euroopa keelemapi tulevikuvõimalustest
Chao, Shi-Wei; Chen, Liang-Chieh; Yu, Chia-Chun; Liu, Chang-Yi; Lin, Tony Eight; Guh, Jih-Hwa; Wang, Chen-Yu; Chen, Chun-Yung; Hsu, Kai-Cheng; Huang, Wei-Jan
2018-01-01
Histone deacetylase (HDAC) is a validated drug target for various diseases. This study combined indole recognition cap with SAHA, an FDA-approved HDAC inhibitor used to treat cutaneous T-cell lymphoma (CTCL). The structure activity relationship of the resulting compounds that inhibited HDAC was disclosed as well. Some compounds exhibited much stronger inhibitory activities than SAHA. We identified two meta-series compounds 6j and 6k with a two-carbon linker had IC 50 values of 3.9 and 4.5 nM for HDAC1, respectively. In contrast, the same oriented compounds with longer carbon chain linkers showed weaker inhibition. The result suggests that the linker chain length greatly contributed to enzyme inhibitory potency. In addition, comparison of enzyme-inhibiting activity between the compounds and SAHA showed that compounds 6j and 6k displayed higher inhibiting activity for class I (HDAC1, -2, -3 and -8). The molecular docking and structure analysis revealed structural differences with the inhibitor cap and metal-binding regions between the HDAC isozymes that affect interactions with the inhibitors and play a key role for selectivity. Further biological evaluation showed multiple cellular effects associated with compounds 6j- and 6k-induced HDAC inhibitory activity. Copyright © 2017 Elsevier Masson SAS. All rights reserved.
Susanto, Johana M; Colvin, Emily K; Pinese, Mark; Chang, David K; Pajic, Marina; Mawson, Amanda; Caldon, C Elizabeth; Musgrove, Elizabeth A; Henshall, Susan M; Sutherland, Robert L; Biankin, Andrew V; Scarlett, Christopher J
2015-05-01
Despite incremental advances in the diagnosis and treatment for pancreatic cancer (PC), the 5‑year survival rate remains <5%. Novel therapies to increase survival and quality of life for PC patients are desperately needed. Epigenetic thera-peutic agents such as histone deacetylase inhibitors (HDACi) and DNA methyltransferase inhibitors (DNMTi) have demonstrated therapeutic benefits in human cancer. We assessed the efficacy of these epigenetic therapeutic agents as potential therapies for PC using in vitro and in vivo models. Treatment with HDACi [suberoylanilide hydroxamic acid (SAHA)] and DNMTi [5‑AZA‑2' deoxycytidine (5‑AZA‑dc)] decreased cell proliferation in MiaPaCa2 cells, and SAHA treatment, with or without 5‑AZA‑dc, resulted in higher cell death and lower DNA synthesis compared to 5‑AZA‑dc alone and controls (DMSO). Further, combination treatment with SAHA and 5‑AZA‑dc significantly increased expression of p21WAF1, leading to G1 arrest. Treatment with epigenetic agents delayed tumour growth in vivo, but did not decrease growth of established pancreatic tumours. In conclusion, these data demonstrate a potential role for epigenetic modifier drugs for the management of PC, specifically in the chemoprevention of PC, in combination with other chemotherapeutic agents.
Ionization equilibrium in dense plasmas
International Nuclear Information System (INIS)
Ying, R.
1987-01-01
The average degree of ionization for a strongly coupled plasma is investigated and calculated. Two widely used approaches: the Saha equation method and the Thomas-Fermi (TF) statistical atomic model are adopted to determine the degree of ionization. Both methods are modified in a number of ways to include the strong-coupling effect in the plasma. In the Saha equation approach, the strong-coupling effects are introduced through: (i) a replacement of the Coulomb potential by a screened Debye potential; (ii) adoption of the Planck-Larkin partition function; (iii) description of the electron component by Fermi-Dirac statistics. The calculated degree of ionization exceeds that obtained from the original Saha equation, exhibits a minimum as a function of the density and shows an abrupt phase transition from weakly ionized to a fully ionized state. The zero-temperature TF model for compressed ions and the finite-temperature TF model for ions are investigated for the first time. In order to take into account the strong-coupling effect in a systematic way, a strong-coupling TF model is set up. Favorable results with the relatively simple approximations indicate that the newly established strong-coupling TF model is a more systematic and physically consistent approach
Saha equation, single and two particle states
International Nuclear Information System (INIS)
Kraeft, W.D.; Girardeau, M.D.; Strege, B.
1990-01-01
Single and two particle porperties in dense plasma are discussed in connection with their role in the mass action law for a partially ionized plasma. The two particle bound states are nearly density independent, while the continuum is essentially shifted. The single particle states are damped, and their energy has a negative shift and a parabolic behaviour for small momenta. (orig.)
Arnold Rüütel ja Toomas Hendrik Ilves raamaturiiulil
2006-01-01
Arnold Rüütel. Tuleviku taassünd. Tallinn : Ilo, 2001; Toomas Kall. Rüütel : rahva keeles ja meeles. Tallinn : Varrak, 2006; Eesti Vabariigi President Arnold Rüütel. [Tallinn] : Ilo, 2006; Arnold Rüütel. Agraar-tööstuskompleksi areng Eesti NSV-s. Tallinn : Valgus, 1982; Arnold Rüütel. President : [valik Vabariigi Presidendi Arnold Rüütli kõnedest]. Tallinn : Eesti Keele Sihtasutus, 2003; Toomas Hendrik Ilves. Eesti jõudmine. Tallinn : Varrak, 2006
Gailit protesteerib : [August Gailiti kiri Valev Uibopuule 14. okt. 1956] / August Gailit
Gailit, August, 1891-1960
1998-01-01
Leonid Treti mälestuste käsikirjast 'A. H. Tammsaare, nagu teda tundsin'. Vastukajad: Siimisker, Leenu. Kultuuri, enam tekstikriitilist kultuuri // Sirp (1998) 13. märts, lk. 18-19 ; Treier, Elem. Klassiku teenimise kibe leib // Sirp (1998) 17. apr., lk. 14 ; Rebane, Hilve. Isikuloolisi lisandusi A. H. Tammsaare tundmisesse // Keel ja Kirjandus (1998) nr. 5, lk. 343-345 ; Kronberg, Janika. Kaanonid ja apokrüüfid // Keel ja Kirjandus (1998) nr. 8, lk. 563-564
Characterization of Seismic Noise at Selected Non-Urban Sites
2010-03-01
Field sites for seismic recordings: Scottish moor (upper left), Enfield, NH (upper right), and vicinity of Keele, England (bottom). ERDC...three sites. The sites are: a wind farm on a remote moor in Scotland, a ~13 acre field bounded by woods in a rural Enfield, NH neigh- borhood, and a site...in a rural Enfield, NH, neighborhood, and a site transitional from developed land to farmland within 1 km of the six-lane M6 motorway near Keele
SOS - помощь родному языку / Виктория Панова
Панова, Виктория
2008-01-01
Tutvustatakse vene keele õpikuid (Ушакова, O. Почему так говорят ; Правописание глаголов, причастий и деепричастий) ja vene keele seletavat sõnaraamatut
Kukemelk, Epp-Mare
2003-01-01
15. jaanuaril lõpeb gümnaasiumilõpetajate registreerimine kevadistele riigieksamitele. Alates 2003. a. kevadest on gümnaasiumide lõpetajatel vaba valik, kas teha inglise keele, matemaatika ja keemia riigieksam täies või üksnes pooles mahus. Gümnaasiumi lõpetamiseks on vaja saada riigieksamil vähemalt 20 punkti. Kõik põhikooli lõpetajad peavad tänavu tegema eesti keele ja matemaatika eksami ning valima lisaks eksami veel ühes aines
Meie tipud 2006 : ¡Eesti kirjanduskriitika artikliauhinnast 2006. aastal / Linnar Priimägi
Priimägi, Linnar, 1954-
2007-01-01
Eesti kirjanduskriitika 2006. aasta artikliauhinna neljast nominendist Anne Lillest (Antiiktragöödia, esteetika paradoksid ja Mati Unt. Keel ja Kirjandus 2006, nr. 6), Toomas Haugist (A. H. T. surm Aafrikas. Lisandusi Leo Frobeniuse "Jumala külalise" kadunud tõlkele. Looming 2006, nr. 6), Märt Väljatagast (Orja teadvus varjus ja valguses. Looming 2006, nr. 12) ja Eneken Laanesest (Mäletamise lühis: Ene Mihkelsoni "Ahasveeruse uni". Keel ja Kirjandus 2006, nr. 6)
Tõlkimise teooriast ja praktikast / Märt Väljataga
Väljataga, Märt, 1965-
2008-01-01
Tõlkimisest ja tõlkekriitikast. 2008. a. ilmunud tõlkimist käsitlevatest väljaannetest: Lange, Anne. Tõlkimise aabits. Tallinn : Valgus, 2008 ; Saluäär, Anu. Põhjamaadest ja Eestist. Tallinn : Eesti Keele Sihtasutus, 2008 ; Kaldjärv, Klaarika. Autor, jutustaja, tõlkija : Borgese autofiktsioonid eesti keeles. Tartu : Tartu Ülikooli Kirjastus, 2008 ; Ain Kaalep 80 : konverentsikogumik. Tartu : Eesti Kirjanduse Selts, 2008. (Eesti Kirjanduse Seltsi aastaraamat 2006 ; 32) ; Steiner, George. Valik esseid / tlk. Triinu Pakk. Tallinn : Kultuurileht, 2008
2012-01-01
Välismaal ilmunud eesti kirjandusest ja eesti kirjanike tegemistest piiri taga: Eric Dickensi tõlkes ilmus inglise keeles Jaan Krossi romaan "Vastutuulelaev" (Sailing Against the Wind) ja eesti lühiproosa kogumik "The Dedalus Book of Estonian Literature" ; Indias esitleti eesti rahvuseepose "Kalevipoeg" Vishnu Khare tõlget hindi keelde ("Kalevputra") ; USA kirjandusajakiri "The Bitter Oleander" pühendas oma viimase numbri 32 lehekülge Kristiina Ehinile ja tema loomingule ; Piret Raua raamat "Printsess Luluu ja härra Kere" (läti keeles "Princese Skella un Leta kungs") võitis esikoha 2011. aasta Läti Lastežürii 3.-4. klassi vanuserühmas ; Viivi Luige teos "Varjuteater", mis ilmus 2011. aastal soome keeles, tunnistati üheks Helsingi Linnaraamatukogu iga-aastase auhinna "12 osumaa" laureaadiks ; UNESCO ülemaailmse luulepäeva tähistamiseks toimunud rahvusvahelisest luulemaratonist võttis osa ka Jüri Talvet
EESTI KEELEKOGUKONNA SÄILIMISEST TAANIS
Directory of Open Access Journals (Sweden)
Maarika Teral
2010-01-01
Full Text Available Käesolev artikkel keskendub Taanis elavatele, põhiliselt Teise maailmasõja ajal ja järel sinna ümber asunud eestlaste ning nende järeltulijate eesti keele kasutuse vaatlemisele. Taani eestlaste kogukond on suhteliselt väike ning on jäänud teiste, suuremate väliseesti kogukondade varju. Taani eestlaste esimeseks põlvkonnaks nimetatakse artiklis neid eestlasi, kes tulid Taani Teise maailmasõja ajal. Teise põlvkonna moodustavad nende lapsed, kes on sündinud juba väljaspool Eestit. Esimene Taani eestlaste põlvkond, kes lahkus Eestist kodumaal omandatud eesti keelega ja on seda keelt läbi pagulasaastate alal hoidnud, on hääbumas, paljud neist on viimastel aastatel elust lahkunud. Pärast Teist maailmasõda või selle ajal sündinud teise põlvkonna taanieestlasi, kes räägivad eesti keelt, on vähem kui elusolevaid esimese põlvkonna taanieestlasi. Carol-Myers Scotton on välja toonud rea faktoreid, mis mõjutavad keele säilimist ja/või vahetust, jagades need kolme rühma: ühiskondlikud, grupisisesed ning individuaalsed (2006. Artiklis analüüsitakse Taani eestlaste eesti keele säilimist ja/või vahetust mõjutavaid tegureid, lähtudes Myers-Scottoni välja toodud faktoritest, tegemaks kindlaks, kas ülekaalus on keele säilitamist või vahetust soosivad tegurid.
Kaubamaja Naistemaailm = Tallinn Kaubamaja Ladies' World / Külli Salum, Riina Harik
Salum, Külli, 1971-
2013-01-01
Tallinna Kaubamaja Naistemaailma (Gonsiori 2) sisekujundusest. Autorid: Külli Salum ja Riina Harik (Saha IN). Skulptuurid: Kalle-Priit Pruuden. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tarmo Piirmetsa arvamus
2011-01-01
Arvustus: Nurklik, Siim. Kas ma olen nüüd elus. Tallinn : S. Nurklik, 2010 ; Lintrop, Aado. Annapurna. Tartu : Ilmamaa, 2010 ; Lintrop, Aado. Õhtud sõidavad õue. Tartu : Ilmamaa, 2011 ; Saar, Anti. Tekste siledast ruumist. Tallinn : Eesti Keele Sihtasutus, 2009 ; Hvostov, Andrei. Sillamäe passioon. Tartu : Petrone Print, 2011 ; Nõu, Helga. Valetaja. Tallinn : Eesti Ajalehed, 2011 ; Malin, Jaan. Alati vahe. Tallinn : Tuum, 2010 ; Jõerüüt, Jaak. Muutlik. Tallinn : Tuum, 2010 ; Luik, Viivi. Varjuteater. Tallinn : Eesti Keele Sihtasutus, 2010
Viis kandidaati ühele õpetajakohale / Raivo Juurak
Juurak, Raivo
2007-01-01
Programmist "Noored kooli", etapi lõpuks selgitati välja 13 noort, kes lähevad tänavu 1. septembril kooli õpetajaks. Oma hinnangu programmile annavad üliõpilased: TTÜ geenitehnoloogiast P. Uuemaa, TTÜ logistikast K. Lillemets, EKA tekstiilidisainist I. Gross, TÜ inglise filoloogiast R. Kurg, TÜ hispaania keele ja politoloogia üliõpilane L. Prikk, TLÜ inglise filoloogiast T.-K. Kaber, TÜ eesti keel vene koolis erialalt N. Reppo, TTÜ geenitehnoloogiast P. Ahte ja TÜ inglise filoloogiast H. Haljaste
Short outlines of books by Estonian authors / Brita Melts, Rutt Hinrikus, Maret Vaher and Arno Oja
Melts, Brita
2014-01-01
Arvustus: Kronberg, Janika. Rännud kuue teejuhiga. Tallinn : Go Group, 2013 ; Kallaste, Helen. Kogutud hetked. Tallinn : Verb, 2012 ; Ahi, Eda. Gravitatsioon. Tallinn : Verb, 2013 ; Heinsaar, Mehis. Ülikond. Tallinn : Menu Kirjastus, 2013 ; Kann, Kaja. Eratee. Tallinn : Hea Lugu, 2013 ; Kivirähk, Andrus. Maailma otsas. Tallinn : Eesti Keele Sihtasutus, 2013 ; Kurvitz, Robert. Püha ja õudne lõhn. Tallinn : ZA/UM, 2013 ; Mattheus, Ülo. Tema salajane palve. Tallinn : Tuum, 2013 ; Kangro, Maarja. Dantelik auk. Tallinn : Eesti Keele Sihtasutus, 2012
2002-01-01
Luuletuste tekst ladina ja kreeka keeles, rööptekst eesti keeles. Eessõna lk. 2493-2501. Kokkuvõte "Congratulations by Riga literati to the Academy of Tartu in 1632", lk. 2696-2697. Acclamationes votivae sub novo auspicio Regiae Dorpatensis Academiae [---] factae ab iis, qui sunt ex ordine Literatorum Rigae Metropolitanae totius Livoniae (Õnnesoovihüüded Tartu Kuningliku Akadeemia uueks õnnelikuks alguseks [---] nende sulest, kes kuuluvad kogu Liivimaa pealinna literaatide seisusesse). Kogumik sisaldas 6 ladinakeelset ja 1 kreekakeelse luuletuse
Colli, Guarino R; Hoogmoed, Marinus S; Cannatella, David C; Cassimiro, José; Gomes, Jerriane Oliveira; Ghellere, José Mário; Gomes, Jerriane Oliveira; Ghellere, José Mário; Nunes, Pedro M Sales; Pellegrino, Kátia C M; Salerno, Patricia; Souza, Sergio Marques De; Rodrigues, Miguel Trefaut
2015-08-18
We describe a new genus and two new species of gymnophthalmid lizards based on specimens collected from Brazilian Amazonia, mostly in the "arc of deforestation". The new genus is easily distinguished from other Gymnophthalmidae by having very wide, smooth, and imbricate nuchals, arranged in two longitudinal and 6-10 transverse rows from nape to brachium level, followed by much narrower, strongly keeled, lanceolate, and mucronate scales. It also differs from all other Gymnophthalmidae, except Iphisa, by the presence of two longitudinal rows of ventrals. The new genus differs from Iphisa by having two pairs of enlarged chinshields (one in Iphisa); posterior dorsal scales lanceolate, strongly keeled and not arranged in longitudinal rows (dorsals broad, smooth and forming two longitudinal rows), and lateral scales keeled (smooth). Maximum parsimony, maximum likelihood, and Bayesian phylogenetic analyses based on morphological and molecular data indicate the new species form a clade that is most closely related to Iphisa. We also address several nomenclatural issues and present a revised classification of Gymnophthalmidae.
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2003-01-01
Sinijärv, Karl- Martin. Artutart & 39. Tallinn : Tuum, 2002 ; Beier, Priidu. Monaco. Tartu : P. Beier, 2002 ; Malin, Jaan. Sulle. Tartu : J. Malin, 2003 ; Liiv, Toomas. Luuletused 1968-2002. Tallinn : Tuum, 2003 ; Mägi, Arvo. Katk ja koolera. Tartu : Ilmamaa ; Kross, Jaan. Omaeluloolisus ja alltekst. Tallinn : Eesti Keele Sihtasutus, 2003 ; Kaplinski, Jaan ; Salminen, Johannes. Ööd valged ja mustad. Tallinn : Loomingu Raamatukogu, 2003 ; Kauksi Ülle. Käänüpäiv. Tartu : Kauksi Ülle Mänedsment', 2003 ; Luik, Tõnu. Filosoofiast kõnelda. Tartu : Ilmamaa, 2002 ; Teder, Tarmo. Pööningujutud. Tallinn : Eesti Keele Sihtasutus, 2002 ; Vetemaa, Enn. Minu väga magus elu ehk martsipanimeister. Tallinn : Tänapäev, 2002 ; Põldroos, Enn. Joonik kivi. Tallinn : Eesti Keele Sihtasutus, 2003 ; Suburg, Lilli. Kogutud kirjatööd. Tallinn : Eesti Raamat, 2002 ; Mikelsaar, Henn. Müüritud. Tartu : Ilmamaa, 2003 ; Kaus, Jan. Õndsate tund. Tallinn : Tuum, c2003
Kohvik Coffee Love = Café "Coffee Love"
2011-01-01
Tallinnas Kristiine keskuses asuva kohviku sisekujundusest. Sisearhitektid Ketsia Reismaa ja Külli Salum (Saha In OÜ). Loetletud sisearhitektide koos tehtud töid ja valik Külli Salumi tehtud töid
HDAC Inhibition Improves the Sarcoendoplasmic Reticulum Ca2+-ATPase Activity in Cardiac Myocytes.
Meraviglia, Viviana; Bocchi, Leonardo; Sacchetto, Roberta; Florio, Maria Cristina; Motta, Benedetta M; Corti, Corrado; Weichenberger, Christian X; Savi, Monia; D'Elia, Yuri; Rosato-Siri, Marcelo D; Suffredini, Silvia; Piubelli, Chiara; Pompilio, Giulio; Pramstaller, Peter P; Domingues, Francisco S; Stilli, Donatella; Rossini, Alessandra
2018-01-31
SERCA2a is the Ca 2+ ATPase playing the major contribution in cardiomyocyte (CM) calcium removal. Its activity can be regulated by both modulatory proteins and several post-translational modifications. The aim of the present work was to investigate whether the function of SERCA2 can be modulated by treating CMs with the histone deacetylase (HDAC) inhibitor suberanilohydroxamic acid (SAHA). The incubation with SAHA (2.5 µM, 90 min) of CMs isolated from rat adult hearts resulted in an increase of SERCA2 acetylation level and improved ATPase activity. This was associated with a significant improvement of calcium transient recovery time and cell contractility. Previous reports have identified K464 as an acetylation site in human SERCA2. Mutants were generated where K464 was substituted with glutamine (Q) or arginine (R), mimicking constitutive acetylation or deacetylation, respectively. The K464Q mutation ameliorated ATPase activity and calcium transient recovery time, thus indicating that constitutive K464 acetylation has a positive impact on human SERCA2a (hSERCA2a) function. In conclusion, SAHA induced deacetylation inhibition had a positive impact on CM calcium handling, that, at least in part, was due to improved SERCA2 activity. This observation can provide the basis for the development of novel pharmacological approaches to ameliorate SERCA2 efficiency.
Resonance – Journal of Science Education | News
Indian Academy of Sciences (India)
mediated Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi · More Details Fulltext PDF. pp 622-629 Series Article. Snippets of Physics - Perturbing Coulomb to Avoid Accidents! T Padmanabhan.
Experimental study of static flow instability in subcooled flow boiling in parallel channels
International Nuclear Information System (INIS)
Siman-Tov, M.; Felde, D.K.; McDuffee, J.L.; Yoder, G.L.
1995-01-01
Experimental data for static flow instability or flow excursion (FE) at conditions applicable to the Advanced Neutron Source Reactor are very limited. A series of FE tests with light water flowing vertically upward was completed covering a local exit heat flux range of 0.7--18 MW/m 2 , exit velocity range of 2.8--28.4 m/s, exit pressure range of 0.117--1.7 MPa, and inlet temperature range of 40-- 50 degrees C. Most of the tests were performed in a ''stiff'' (constant flow) system where the instability threshold was detected through the minimum of the pressure-drop curve. A few tests were also conducted using as ''soft'' (constant pressure drop) a system as possible to secure a true FE phenomenon (actual secondary burnout). True critical heat flux experiments under similar conditions were also conducted using a stiff system. The FE data reported in this study considerably extend the velocity range of data presently available worldwide, most of which were obtained at velocities below 10 m/s. The Saha and Zuber correlation had the best fit with the data out of the three correlations compared. However, a modification was necessary to take into account the demonstrated dependence of the St and Nu numbers on subcooling levels, especially in the low subcooling regime. Comparison of Thermal Hydraulic Test Loop (THTL) data, as well as extensive data from other investigators, led to a proposed modification to the Saha and Zuber correlation for onset of significant void, applied to FE prediction. The mean and standard deviation of the THTL data were 0.95 and 15%, respectively, when comparing the THTL data with the original Saha and Zuber correlation, and 0.93 and 10% when comparing them with the modification. Comparison with the worldwide database showed a mean and standard deviation of 1.37 and 53%, respectively, for the original Saha and Zuber correlation and 1.0 and 27% for the modification
International Nuclear Information System (INIS)
Feng Hongyan; Zhu Shunguan; Zhang Lin; Wan Xiaoxia; Li Yan; Shen Ruiqi
2010-01-01
Emission spectra of a semiconductor bridge (SCB) plasma in a visible range was studied in air. The electron density was measured in a conventional way from the broadening of the A1 I 394.4 nm Stark width. Based on the Saha equation, a system for recording the intensity of Si I 390.5 nm and Si II 413.1 nm was designed. With this technique, the SCB plasma electron density was measured well and accurately. Moreover, the electron density distribution Vs time was acquired from one SCB discharge. The individual result from the broadening of the Al I 394.4 nm Stark width and Saha equation was all in the range of 10 15 cm -3 to 10 16 cm -3 . Finally the presumption of the local thermodynamic equilibrium (LTE) condition was validated.
Kultuurisild : eesti muinasjutud ilmusid hiina keeles
2010-01-01
18. okt. esitleti maailmanäitusel EXPO Hiinas Shanghais esimest eesti keelest hiina keelde tõlgitud raamatut, kogumikku August Jakobsoni ja Friedrich Reinhold Kreutzwaldi muinasjuttudest Jüri Mildebergi illustratsioonidega. Proua Evelin Ilves osales raamatu esitlusel Shanghai Lasteraamatukogus
Eesti kirjandus ungari ja inglise keeles
2006-01-01
16. detsembril esitleti Budapestis ajakirja Nagyvilag Eesti numbrit. Ajakiri kannab alapealkirja "Maarjamaa, Jumala jalgealune". Londoni kirjastus Dalkey Archive Press andis välja Mati Undi romaani "Öös on asju" inglisekeelse tõlke "Things in the night"
Jüri Talveti luulevalimik hispaania keeles
2003-01-01
Talvet, Jüri. Elegia Estonia y otros poemas : [luulevalimik] / tõlkinud Jüri Talvet ja Albert Lázaro Tinaut ; järelsõna Janika Kronberg. Valencia : Palmart Capitelum, 2002; Vt. ka Eesti Päevaleht, 13. jaan., lk. 16
2007-01-01
Jaan Unduski näidend "Good-bye, Vienna" tõlgiti soome keelde ja loeti ette festivalil "Baltic Circle". Samal üritusel loeti ette ka lätlase Inga Abele ja leedulase Marius Ivashkevichiuse näidendeid
Effects of three-body atomic interaction and optical lattice on solitons ...
Indian Academy of Sciences (India)
one-dimensional. Bose–Einstein condensate. Sk GOLAM ALI, B TALUKDAR∗ and APARNA SAHA. Department of Physics, Visva-Bharati University, Santiniketan 731 235, India. *Corresponding author. E-mail: binoy123@bsnl.in. MS received 23 ...
Indian Academy of Sciences (India)
adhikari@saha.ac.in. Agrawal Pankaj, Institute of Physics,. Bhubaneswar, India agrawal@iopb.res.in. Agrawalla Sanjib K, Harish-Chandra. Research Institute, Allahabad, India sanjib@mri.ernet.in. Allanach Benjamin C, University of. Cambridge ...
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2008-01-01
Arvustus: Kareva, Doris. Lõige. Tallinn : Verb, 2007 ; Õnnepalu, Tõnu. Flandria päevik. Tallinn : Varrak, 2007 ; Mihkelson, Ene. Katkuhaud. Tallinn : Varrak, 2007 ; Vint, Toomas. Mäluauguga naine. Tallinn : Eesti Keele Sihtasutus, 2007 ; Pervik, Aino. Suleline, Puhuja ja must munk. Tallinn : Tänapäev, 2007 ; Mutt, Mihkel. Siseemigrant. Novellid Rui taevalike kommentaaridega. Tallinn : Fabian, 2007 ; Nõlvak, Valentine. Ellujääja mälestused. Tallinn : Varrak, 2007 ; Tungal, Leelo. Täisminevik. Tallinn : Tänapäev, 2007 ; Kangro, Maarja. Tule mu koopasse, mateeria. Tallinn : Eesti Keele Sihtasutus, 2007
Kas Euroopa Liidu idapiir hakkab tulevikus kulgema Lasnamäel? / Svea Otsmaa
Otsmaa, Svea
2003-01-01
Majandusõpetust kureeriva Eesti Junior Achievementì korraldusel toimusid 1.03.2003 piirkondlikud majandusolümpiaadid. Harjumaa koolide esindused võistlesid Maardu Gümnaasiumis, kes oli 2002. aastal Harjumaa koolide võistluste võitja. Keila-Joa Sanatoorse Internaatkooli meeskonnale kujunes see äpardunud ettevõtmiseks, sest asjaajamine toimus ainult vene keeles. Teine probleem on vene noortega, kes on sulgunud 99% venekeelsetesse kohtadesse, nagu Narva, Kohtla-Järve ja Sillamäe ja ka Maardu. Ida-Virumaa venekeelsel elanikkonnal on kadunud eesti keele õppimise entusiasm, sest sealkandis eesti keelt vaja ei ole
Towards an integrated observing system for ocean carbon and biogeochemistry at a time of change
CSIR Research Space (South Africa)
Gruber, N
2009-09-01
Full Text Available . The longest time-series for inorganic carbon started in the early 1980s (Keeling, 1993, Gruber et al., 2001; Bates, 1997) near Bermuda and in 1988 was joined by a second time-series near Hawaii (Sabine et al., 1995; Dore et al., 2003; Keeling et al., 2004... century primarily as a result of the burning of fossil fuels (Sarmiento and Gruber, 2002). In response, atmospheric CO2 has GRUBER ET AL: AN INTEGRATED BIOGEOCHEMICAL OBSERVING SYSTEM 2 increased by more than 100 ppm (30%), with today’s concentration...
PREFACE: Continuum Models and Discrete Systems Symposia (CMDS-12)
Chakrabarti, Bikas K.
2011-09-01
The 12th International Symposium on Continuum Models and Discrete Systems (CMDS-12) (http://www.saha.ac.in/cmp/cmds.12/) took place at the Saha Institute of Nuclear Physics in Kolkata from 21-25 February 2011. Previous CMDS symposia were held in Kielce (Poland, 1975), Mont Gabriel (Canada, 1977), Freudenstadt (Federal Republic of Germany, 1979), Stockholm (Sweden, 1981), Nottingham (United Kingdom, 1985), Dijon (France, 1989), Paderborn (Germany, 1992), Varna (Bulgaria, 1995), Istanbul (Turkey, 1998), Shoresh (Israel, 2003) and Paris (France, 2007). The broad interdisciplinary character, limited number of participants (not exceeding 100) and informal and friendly atmosphere of these meetings has made them a well-acknowledged place to make highly fruitful contacts and exchange ideas, methods and results. The purpose of CMDS is to bring together scientists with different backgrounds who work on continuum theories of discrete mechanical and thermodynamical systems in the fields of mathematics, theoretical and applied mechanics, physics, material science, and engineering. The spirit of the CMDS meetings is to stimulate extensive and active interdisciplinary research. The International Scientific Committee members of this conference were: David J Bergman (Chairman CMDS 10), Tel Aviv University, Israel; Bikas K Chakrabarti (Chairman CMDS 12), Saha Institute of Nuclear Physics, India; Alex Hansen, Norwegian University of Science and Technology, Norway; Hans Jürgen Herrmann, Institute for Building Materials, ETH, Switzerland; Esin Inan (Chairman CMDS 9), Istanbul Technical University, Turkey; Dominique Jeulin (Chairman CMDS 11), Ecole des Mines de Paris, France; Frank Juelicher, Max-Planck-Institute for the Physics of Complex Systems, Germany; Hikaru Kawamura, University of Osaka, Japan; Graeme Milton, University of Utah, USA; Natalia Movchan, University of Liverpool, UK; and Ping Sheng, The Hong Kong University of Science and Technology, Hong Kong. At CMDS-12 the topics
Body-induced vortical flows: a common mechanism for self-corrective trimming control in boxfishes.
Bartol, Ian K; Gharib, Morteza; Webb, Paul W; Weihs, Daniel; Gordon, Malcolm S
2005-01-01
Boxfishes (Teleostei: Ostraciidae) are marine fishes having rigid carapaces that vary significantly among taxa in their shapes and structural ornamentation. We showed previously that the keels of the carapace of one species of tropical boxfish, the smooth trunkfish, produce leading edge vortices (LEVs) capable of generating self-correcting trimming forces during swimming. In this paper we show that other tropical boxfishes with different carapace shapes have similar capabilities. We conducted a quantitative study of flows around the carapaces of three morphologically distinct boxfishes (spotted boxfish, scrawled cowfish and buffalo trunkfish) using stereolithographic models and three separate but interrelated analytical approaches: digital particle image velocimetry (DPIV), pressure distribution measurements, and force balance measurements. The ventral keels of all three forms produced LEVs that grew in circulation along the bodies, resembling the LEVs produced around delta-winged aircraft. These spiral vortices formed above the keels and increased in circulation as pitch angle became more positive, and formed below the keels and increased in circulation as pitch angle became more negative. Vortices also formed along the eye ridges of all boxfishes. In the spotted boxfish, which is largely trapezoidal in cross section, consistent dorsal vortex growth posterior to the eye ridge was also present. When all three boxfishes were positioned at various yaw angles, regions of strongest concentrated vorticity formed in far-field locations of the carapace compared with near-field areas, and vortex circulation was greatest posterior to the center of mass. In general, regions of localized low pressure correlated well with regions of attached, concentrated vorticity, especially around the ventral keels. Although other features of the carapace also affect flow patterns and pressure distributions in different ways, the integrated effects of the flows were consistent for all forms
Construction of classical and quantum integrable field models ...
Indian Academy of Sciences (India)
Theory Division, Saha Institute of Nuclear Physics, Kolkata 700 064, India .... above models takes only two different forms: rational or trigonometric ..... parameters c, α, μ, which for different continuum choices for these parameters allows to. 910.
African Journals Online (AJOL)
2009-10-01
Oct 1, 2009 ... tests of attention and concentration, movement and co- ordination ... Africa, but it was insensitive to memory impairment in asymptomatic HIV-positive patients. 38 ... ments may be affected by different clades in sub-Saha-.
In this section of Resonance, we invite readers to pose questions ...
Indian Academy of Sciences (India)
Author Affiliations. Kaushik Basu1 Suchandra Chakraborty2 Chandan Saha2. Department of Chemistry St Paul's Cathedral Mission College Kolkata 700 009, India. Department of Clinical and Experimental Pharmacology School of Tropical Medicine Kolkata 700 073, India.
Resonance – Journal of Science Education | Indian Academy of ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 17; Issue 8. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature. Chandan Saha Suchandra Chakraborty. General Article Volume 17 Issue 8 August 2012 pp 768-778 ...
Directory of Open Access Journals (Sweden)
Andressa Cavalcante Meireles
2015-12-01
Full Text Available Periandra mediterranea (Vell. Taub. has papilionaceous flowers with a complex pollination mechanism. This study examined pollination and reproduction in P. mediterranea from November 2009 to October 2011 at the Guaribas Biological Reserve, Paraíba, Brazil. The petals are modified in a keel that protects the stamens and stigma; two wings surround the keel, and a standard that serves as landing platform for floral visitors. Periandra mediterranea exhibits an explosive type pollination mechanism in which the bee species Xylocopa frontalis, Acanthopus excellens and Epicharis sp., land on the standard and, due to body weight, expose the reproductive organs in the wing-keel complex. As a result, the reproductive organs of the flower come into contact with the dorsal region of the bee body, depositing pollen (i.e., nototríbic pollination. Reproductive assays showed 20% fruiting in spontaneous auto-pollination, 33% in manual auto-pollination, 33% in manual cross-pollination, and 100% in the control group, with no reproductive success while in apomixis. These results demonstrate self-compatibility in this species, however it depends on pollinators to ensure reproductive success.
On some three-dimensional problems of piezoelectricity | Saha ...
African Journals Online (AJOL)
The problem of an elliptical crack embedded in an unbounded transversely isotropic piezoelectric medium and subjected to remote normal loading is considered first. The integral equation method developed by Roy and his coworkers has been applied suitably with proper modifications to solve the problem. The method ...
Indian Academy of Sciences (India)
-organic chemical vapour deposited (MOCVD) gamma iron oxide thin film for ... V2)5-Te)2 glasses using heterogeneous conductor model -- M Pal, S K Saha and ... The hardness-flow stress correlation in metallic materials -- G Soundararajan ...
Fluid phases of hydrogen-bound states and thermodynamical properties
International Nuclear Information System (INIS)
Ebeling, W.; Kraeft, W.D.
1985-08-01
The fluid phases of hydrogen and especially the existence of two critical points, the density dependence of the two - particle states and the effective interactions are discussed. An effective Schroedinger equation and a Saha equation are given. (author)
Endoscopic versus external approach dacryocystorhinostomy: A ...
African Journals Online (AJOL)
Endoscopic versus external approach dacryocystorhinostomy: A comparative analysis. Rinki Saha, Anuradha Sinha, Jyoti Prakash Phukan. Abstract. Background: Dacryocystorhinostomy (DCR) consists of creating a lacrimal drainage pathway to the nasal cavity to restore permanent drainage of previously obstructed ...
Indian Academy of Sciences (India)
overwhelming as to make the practice of science incomparably more difficult ... Romi Bhabha and, say, Megh N ad Saha on what needed to be. "Most of ... "Art, music, poetry ... quantum mechanics, and elementary particle physics at that time.
Enhanced collaboration between CERN and India
2009-01-01
On Monday 22 June, Bikash Sinha, Director of the SAHA Institute of Nuclear Physics (SINP) and the Variable Energy Cyclotron Centre (VECC) in Kolkata, India and Rolf Heuer, CERN Director-General, signed new protocols to the long standing agreement between the Indian Atomic Energy Commission and CERN. This provides a framework for collaboration in low energy nuclear physics between SAHA and VECC and the ISOLDE experiment at CERN. SINP and VECC Director Bikash Sinha and CERN Director-General Rolf Heuer signing the ISOLDE Protocols. SINP and VECC Director Bikash Sinha and CERN Research Director Sergio Bertolucci with representatives of the ISOLDE and RD51 Collaborations.INDIA has a long standing tradition in basic nuclear physics and nuclear chemistry. SINP is a leading institute for basic research and training in physical and biophysical sciences with particular competence in nuclear spectroscopy a...
Directory of Open Access Journals (Sweden)
Kongmalai Pinkawas
2017-01-01
Full Text Available Purpose and hypothesis: Acromion spur is the extrinsic factor for impingement syndrome and rotator cuff tear. The Rockwood tilt view can be used to evaluate prominence of the anterior acromion, however no study has shown the correlation of findings between the Rockwood tilt view and the arthroscopic finding. Methods: We developed the arthroscopic classification of acromion spur as type 1 flat spur, type 2 bump spur, type 3 heel spur, type 4 keel spur, and type 5 irregular spur. Patients with rotator cuff syndrome who underwent arthroscopic surgery were recruited. Two observers were asked to classify the type of spur from arthroscopic findings and Rockwood tilt views separately in random pattern. The prevalence of supraspinatus tendon tear was also recorded as no tear, partial-thickness tear, and full-thickness tear. Results: The keel spur (33.9% was the most common finding followed by the heel spur (27.8%. The correlation was high especially for the heel, the keel, and the irregular spur (75.47%, 74.03%, and 72.73%, respectively. These three types of spurs have a high prevalence of full thickness of supraspinatus tendon tear. Conclusion: The Rockwood tilt view can be used to evaluate the morphology of an acromion spur, especially the at-risk spur that correlates highly with the full-thickness supraspinatus tendon tear. The arthroscopic classification will also be a useful tool to improve communication between the surgeon and the guide for appropriate treatment in a rotator cuff tear patient when encountering the heel, keel, and irregular spur.
Kahe keelekasutusvariandi võrdlus: morfoloogilised klassid ja klastrid
Directory of Open Access Journals (Sweden)
Pille Eslon
2013-10-01
Full Text Available Kasutuspõhise keelekirjelduse väärtus grammatika jaoks seisneb võimaluses avada keelesüsteemi funktsionaalne potentsiaal, kirjeldades näiteks keelestruktuuride hierarhiat, võrreldes keelekasutusvariantide morfosüntaktilisi mustreid, keelesüsteemist ja keelekasutaja valikutest tulenevaid semantilisi ja grammatilisi kitsendusi, keelekasutuse leksikaalse ja grammatilise varieeruvuse piire. Nende esiletoomine vajab meetodeid, mis annaksid võimalikult usaldusväärseid tulemusi. Siinses uurimuses on kasutatud klasteranalüüsi. Võrreldud on eesti ilukirjandus- ja õppijakeele tekstide verbist vasakule jääva konteksti keelekasutust. Leitud on kõik kolmest üksusest koosnevad konstruktsioonid, rühmitatud need morfosüntaktilise samalaadsuse ja sageduse alusel ning kirjeldatud morfoloogiliste klastrite ja klasside hierarhiana. Klassid näitavad keelekasutuse üldiseid morfoloogilisi mustreid, klastrite alusel saab kirjeldada klasside morfoloogilise varieeruvuse piire. Konkreetsed konstruktsioonid toovad esile piiranguid klastrite leksikaalgrammatilisele varieeruvusele. Eesti ilukirjandustekstide ja keeleõppija loomingulist laadi esseede võrdlusest peaks selguma, kuidas kasutavad keelesüsteemi funktsionaalset potentsiaali emakeelekõneleja ja õppija. Analüüsi tulemused näitavad, et emakeelekõnelejad teevad optimaalseid valikuid, mis hõlmavad nii morfosüntaktilist lihtsust kui ka keerukust, nii sõnavara rikkust kui ka kinnistunud korduvkasutust. Selles osas on õppija keelekasutus nihkes, emakeelekõneleja keeletunnetuse põhjal kuidagi ebaharilik. Samas ei tähenda see, et tegu oleks vigadega. Ühelt poolt näitavad õppija kasutatud keelestruktuurid ilukirjanduskeelest avaramat varieeruvust. Teisalt tuleb selgelt esile stereotüüpsetele keelestruktuuridele tuginev lihtsustamine, morfoloogiliste klasside ja klastrite üle- ning alakasutus, sõnavara kesisus.
Indian Academy of Sciences (India)
ufrj.br. Majumdar Shaoli, UGC-DAE Consortium for Scientific Research, Kolkata Centre,. 3/LB-8, Bidhan Nagar, Kolkata 700 098, India shaoli.81@gmail.com. Majumder Harasit, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar,. Kolkata 700 ...
Tallinna Pedagoogikaülikooli magistreid 2004 / Katrin Aava, Toomas Liiv, Helle Metslang
Aava, Katrin, 1963-
2005-01-01
Eesti keele, soome keele ja kommunikatsiooni eriala magistritöödest. Ka viis kirjandusteaduslikku tööd: Kerli Linnati "The vision of history of E. L. Doctorow in English and in Estonian: a comarative study of "Ragtime" and "Look Lake" and their translations", Anneli Niitsoo "Postmodern play with power and masculinity in Jeanette Winterson's Novels", Pille Riismaa "Gümnaasiumi kirjandusõpik "Eelmise sajandi eesti kirjandus"", Anneli Kõvamehe "Baltisakslased Jaan Krossi "Kolmandates mägedes", "Keisri hullus" ja Rakvere romaanis"", Jaak Urmeti "Kultuuri eest ja religiooni vastu. Max Laossoni usuvastasest paljastustööst ajakirjas "Ratsionalist" (1932-1933)"
Novel sex-related characteristics of the longsnout seahorse Hippocampus reidi Ginsburg, 1933
Directory of Open Access Journals (Sweden)
Tacyana P. R Oliveira
Full Text Available This paper presents novel sex-related characteristics in Hippocampus reidi, expressed as a prominent and pigmented keel (males only, and by a row of dorsolateral spots mostly (97.4% found in males. While the keel was found even in the smallest males sampled, the dorsolateral spots appear to be associated with body size. Ex situ observations revealed that during courtship males highlighted both characters by turning pale their background body colour. Understanding such colour and behavioural patterns is relevant to increase our knowledge about sexual selection in a morphologically and biologically unique group of fishes.
Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus
Kronberg, Janika, 1963-
2006-01-01
Arvustus: Runnel, Hando. Sinamu. Tartu : Ilmamaa, 2005 ; Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005 ; Nõu, Enn. Mõtusekuke viimne kogupauk. Tallinn : Eesti Keele Sihtasutus, 2005 ; Merca. Hele häärber. Tartu : Vilep & Vallik, 2005 ; Õnnepalu, Tõnu. Enne heinaaega ja hiljem : luulet ja luuletõlkeid 1983-2005. Tallinn : Eesti Keele Sihtasutus, 2005 ; Kaplinski, Jaan. Kõik on ime. Tartu : Ilmamaa, 2004 ; Unt, Mati. Vend Antigone, ema Oidipus. Tallinn : Kultuurileht, 2006 ; Laretei, Käbi. Otsekui tõlkes : teema variatsioonidega. Tallinn : Tänapäev, 2005 ; Jõerüüt, Jaak. Sõber : valik novelle 1979-2005. Tallinn : Tuum, 2005
Rang, Hendrick
2014-01-01
Kurtusest ja viipekeelest, viipekeele kui keele reguleerimisest, viipekeele kui puuet kompenseeriva suhtlusabivahendi reguleerimisest rahvusvahelises õiguses, viipekeele õiguslikust seisundist Eestis
Indian Academy of Sciences (India)
Admin
748 C- Past, Present, and Future - A Perspective. KBhaskar. 759. Plant Tissue Culture. Historical Developments and Applied Aspects. HR Dagla. 768. Dissymmetry and Asymmetry. A Hopeless Conflict in Chemical Literature. Chandan Saha and Suchandra Chakraborty. 768. RESEARCH NEWS. 791. Substrate Channelling.
Indian Academy of Sciences (India)
THE ORIGIN OF MASS IN NEUTRONS AND PROTONS.·. By M. N. SAHA ... of GalUeo--Newtonian mechanics, but discoveries in physics within the last sixty years have .... Before 1932, the other fundamental particle was the proton. The task of ...
A new spectrofluorimetric assay method for vandetanib in tablets ...
African Journals Online (AJOL)
556. 7. Balwani G, Joseph E, Reddi S, Nagpal V, Saha RN. Rapid, Simple, and Sensitive Spectrofluorimetric Method for the Estimation of Ganciclovir in Bulk and. Pharmaceutical Formulations. J Spectrosc 2013;. 2013:1-5. 8. Bai F, Johnson J, ...
In this section of Resonance, we invite readers to pose questions ...
Indian Academy of Sciences (India)
2016-08-26
Aug 26, 2016 ... Author Affiliations. Kaushik Basu1 Suchandra Chakraborty2 Chandan Saha2. Department of Chemistry St Paul's Cathedral Mission College Kolkata 700 009, India. Department of Clinical and Experimental Pharmacology School of Tropical Medicine Kolkata 700 073, India.
Near-horizon states of black holes and Calogero models -2
Indian Academy of Sciences (India)
Theory Division, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, ... We find self-adjoint extensions of the rational Calogero model in the presence .... positive integer, corresponding to the choice of z = z1 = π + 2η1. similarly, when.
Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Recognition of self-assembled water-nitrate cluster in a Co(III)-2,2'-bipyridine host: Synthesis, X-ray structure, DNA cleavage, molecular docking and anticancer activity · SUBRATA DAS ANANDAN RANJANI LOGANATHAN GAYATHRI SUBHASISH SAHA JORGE PASAN DHARUMADURAI DHANASEKARAN MOHAMMAD ...
Indian Academy of Sciences (India)
Admin
455 The Major Players in Adaptive Immunity. Humoral Immunity. Asama Ahmed, Banishree Saha, Anand Patwardhan,. Shwetha Shivaprasad and Dipankar Nandi. 472 The Saga of the HIV Controversy. Nobel Prize in Physiology or Medicine – 2008. Udaykumar Ranga. 430. 416. 508 ...
Indian Academy of Sciences (India)
WHEPP-8 received partial financial support from Indian Institute of Technology,. Mumbai, Tata Institute of Fundamental Research, Mumbai, Harish-Chandra Re- search Institute, Allahabad, Saha Institute of Nuclear Physics, Kolkata, Institute of Physics, Bhubaneswar, Institute of Mathematical Sciences, Chennai. We thank.
Energy Technology Data Exchange (ETDEWEB)
Reid, Alicia E. [National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 (United States); Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)], E-mail: areid@bnl.gov; Hooker, Jacob; Shumay, Elena; Logan, Jean; Shea, Colleen; Kim, Sung Won [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States); Collins, Shanika [School of Science, Health and Technology Medgar Evers College, Brooklyn, NY 11225 (United States); Xu Youwen [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States); Volkow, Nora [National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892 (United States); National Institute on Drug Abuse, Bethesda, MD 20892 (United States); Fowler, Joanna S. [Medical Department, Brookhaven National Laboratory, Upton, NY 11973 (United States)
2009-04-15
Introduction: Histone deacetylases (HDACs) are enzymes involved in epigenetic modifications that shift the balance toward chromatin condensation and silencing of gene expression. Here, we evaluate the utility of 6-([{sup 18}F]fluoroacetamido)-1-hexanoicanilide ([{sup 18}F]FAHA) for positron emission tomography imaging of HDAC activity in the baboon brain. For this purpose, we assessed its in vivo biodistribution, sensitivity to HDAC inhibition, metabolic stability and the distribution of the putative metabolite [{sup 18}F]fluoroacetate ([{sup 18}F]FAC). Methods: [{sup 18}F]FAHA and its metabolite [{sup 18}F]FAC were prepared, and their in vivo biodistribution and pharmacokinetics were determined in baboons. [{sup 18}F]FAHA metabolism and its sensitivity to HDAC inhibition using suberanilohydroxamic acid (SAHA) were assessed in arterial plasma and by in vitro incubation studies. The chemical form of F-18 in rodent brain was assessed by ex vivo studies. Distribution volumes for [{sup 18}F]FAHA in the brain were derived. Results: [{sup 18}F]FAHA was rapidly metabolized to [{sup 18}F]FAC, and both labeled compounds entered the brain. [{sup 18}F]FAHA exhibited regional differences in brain uptake and kinetics. In contrast, [{sup 18}F]FAC showed little variation in regional brain uptake and kinetics. A kinetic analysis that takes into account the uptake of peripherally produced [{sup 18}F]FAC indicated that SAHA inhibited binding of [{sup 18}F]FAHA in the baboon brain dose-dependently. In vitro studies demonstrated SAHA-sensitive metabolism of [{sup 18}F]FAHA to [{sup 18}F]FAC within the cell and diffusion of [{sup 18}F]FAC out of the cell. All radioactivity in brain homogenate from rodents was [{sup 18}F]FAC at 7 min postinjection of [{sup 18}F]FAHA. Conclusion: The rapid metabolism of [{sup 18}F]FAHA to [{sup 18}F]FAC in the periphery complicates the quantitative analysis of HDAC in the brain. However, dose-dependent blocking studies with SAHA and kinetic modeling
Sadhana | Indian Academy of Sciences
Indian Academy of Sciences (India)
Narendra Gajbhiye1 V Eswaran2 A K Saha1 Anoop Kumar3. Department of Mechanical Engineering, IIT Kanpur, Kanpur 208016, India; Department of Mechanical and Aerospace Engineering, IIT Hyderabad, Hyderabad 502205, India; Department of Mechanical Engineering, NIT Hamirpur, Hamirpur 177005, India ...
Resonance – Journal of Science Education | Indian Academy of ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 5. The Major Players in Adaptive Immunity - Humoral Immunity. Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivprasad Dipankar Nandi. General Article Volume 14 Issue 5 May 2009 pp 455-471 ...
The Major Players in Adaptive Immunity-Cell-mediated Immunity
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education; Volume 14; Issue 6. The Major Players in Adaptive Immunity - Cell-mediated Immunity. Asma Ahmed Banishree Saha Anand Patwardhan Shwetha Shivaprasad Dipankar Nandi. General Article Volume 14 Issue 6 June 2009 pp 610-621 ...
Journal of Earth System Science | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Journal of Earth System Science; Volume 126; Issue 4. Deep learning for predicting the monsoon over the homogeneous regions of India. Moumita Saha Pabitra Mitra ... Keywords. Feature learning; stacked autoencoder; monsoon predictor; ensemble of regression trees; regional Indian summer monsoon.
Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Author Affiliations. G Mariappan1 B P Saha1 Sriparna Datta1 Deepak Kumar1 P K Haldar2. Department of Medicinal Chemistry, Himalayan Pharmacy Institute, East Sikkim 737 136, India; Department of Pharmacology, Himalayan Pharmacy Institute, East Sikkim 737 136, India ...
Indian Academy of Sciences (India)
sharing personal experiences and viewpoints on matters related to teaching and learning science. Abhishek Saha. B. Math. Hons. 1st year ... Proof. Let Pb P2,. ,Ps be the various distinct prime divisors of p - 1. Thus. E=.!. k p-1 s. Pj.
Indian Academy of Sciences (India)
Chandra Research Institute, Allahabad; Institute of Mathematical Sciences,. Chennai; International Union of Pure and Applied Physics; Saha Institute of. Nuclear Physics, Kolkata and Tata Institute of Fundamental Research, Mumbai for their generous financial support. Rohini Godbole. Indian Institute of Science, Bangalore ...
"Meaning" and "context" in the language of architecture / Janis Taurens
Taurens, Janis
2008-01-01
Arhitektuuri tähenduse filosoofilisest interpretatsioonist, keelefilosoofia teooriate rakendamisest arhitektuuri kui keele mudelil, arhitektuurisemantikast, arhitektuuriteooria analüüsist keelefilosoofia vahenditega
SARIYER, BEYKOZ VE ŞİLE’DE (İSTANBUL) COĞRAFYA EĞİTİMİ İÇİN ROTA ÖNERİLERİ
Tuna, Fikret; Sarıkaya, Mehmet Akif
2014-01-01
Konusu yani inceleme alanı gereği doğal çevrenin yerinde incelenmesine, gözleme ve uygulamaya dayalı bir bilim olan coğrafyada, öğretilen pek çok konunun sınıfın dışına çıkılarak yerinde gözlenmesi ve incelenmesi büyük önem taşımaktadır. Bu nedenle, coğrafya denilince ilk akla gelenlerden birisi yerinde gözlem ve inceleme yani saha çalışmalarıdır. Ayrıca, saha çalışmaları, coğrafya eğitimine çok çeşitli katkılar sağlamaktadır. Bu çalışmanın temel amacı, coğrafya eğitimcilerine derslerinde fay...
International Nuclear Information System (INIS)
Shi, Zongqian; Wang, Kun; Li, Yao; Shi, Yuanjie; Wu, Jian; Jia, Shenli
2014-01-01
The electron chemical potential and ion charge state (average ion charge and ion distribution) are important parameters in calculating plasma conductivity in electrical explosion of metal wire. In this paper, the calculating method of electron chemical potential and ion charge state is discussed at first. For the calculation of electron chemical potential, the ideal free electron gas model and Thomas-Fermi model are compared and analyzed in terms of the coupling constant of plasma. The Thomas-Fermi ionization model, which is used to calculate ion charge state, is compared with the method based on Saha equation. Furthermore, the influence of electron degenerated energy levels and ion excited states in Saha equation on the ion charge state is also analyzed. Then the influence of different calculating methods of electron chemical potential and ion charge state on plasma conductivity is discussed by applying them in the Lee-More conductivity model
What Drives Carbon Isotope Fractionation by the Terrestrial Biosphere?
Still, Christopher; Rastogi, Bharat
2017-11-01
During photosynthesis, terrestrial plants preferentially assimilate the lighter and much more abundant form of carbon, 12C, which accounts for roughly 99% of naturally occurring forms of this element. This photosynthetic preference for lighter carbon is driven principally by differences in molecular diffusion of carbon dioxide with differing 13C/12C across stomatal pores on leaves, followed by differences in carboxylation rates by the Rubisco enzyme that is central to the process of photosynthesis. As a result of these slight preferences, which work out to about a 2% difference in the fixation rates of 12CO2 versus 13CO2 by C3 vegetation, plant tissues are depleted in the heavier form of carbon (13C) relative to atmospheric CO2. This difference has been exploited in a wide range of scientific applications, as the photosynthetic isotope signature is passed to ecosystem carbon pools and through ecological food webs. What is less appreciated is the signature that terrestrial carbon exchanges leave on atmospheric CO2, as the net uptake of carbon by land plants during their growing season not only draws down the local CO2 concentration, it also leaves behind relatively more CO2 molecules containing 13C. The converse happens outside the growing season, when autotrophic and heterotrophic respiration predominate. During these periods, atmospheric CO2 concentration increases and its corresponding carbon isotope composition becomes relatively depleted in 13C as the products of photosynthesis are respired, along with some small isotope fractionation that happen downstream of the initial photosynthetic assimilation. Similar phenomena were first observed at shorter time scales by the eminent carbon cycle scientist, Charles (Dave) Keeling. Keeling collected samples of air in glass flasks from sites along the Big Sur coast that he later measured for CO2 concentration and carbon isotope composition (δ13C) in his lab (Keeling, 1998). From these samples, Keeling observed increasing
Directory of Open Access Journals (Sweden)
Andressa Cavalcante Meireles
2015-09-01
Full Text Available http://dx.doi.org/10.5007/2175-7925.2015v28n4p71 Periandra mediterranea (Vell. Taub. has papilionaceous flowers with a complex pollination mechanism. This study examined pollination and reproduction in P. mediterranea from November 2009 to October 2011 at the Guaribas Biological Reserve, Paraíba, Brazil. The petals are modified in a keel that protects the stamens and stigma; two wings surround the keel, and a standard that serves as landing platform for floral visitors. Periandra mediterranea exhibits an explosive type pollination mechanism in which the bee species Xylocopa frontalis, Acanthopus excellens and Epicharis sp., land on the standard and, due to body weight, expose the reproductive organs in the wing-keel complex. As a result, the reproductive organs of the flower come into contact with the dorsal region of the bee body, depositing pollen (i.e., nototríbic pollination. Reproductive assays showed 20% fruiting in spontaneous auto-pollination, 33% in manual auto-pollination, 33% in manual cross-pollination, and 100% in the control group, with no reproductive success while in apomixis. These results demonstrate self-compatibility in this species, however it depends on pollinators to ensure reproductive success.
Pastuhhova, Olga
2015-01-01
Kirjeldatakse venekeelsete eesti keele õppijate kirjutamisprotsessi mikrokonteksti mõiste abil. Uurimismaterjal on kogutud klaviatuuri klahvivajutuste salvestuse meetodil põhineva programmiga ScriptLog
Uchida, Hiroshi; Maruyama, Tetsuo; Nishikawa-Uchida, Sayaka; Oda, Hideyuki; Miyazaki, Kaoru; Yamasaki, Akiko; Yoshimura, Yasunori
2012-01-01
Human embryo implantation is a critical multistep process consisting of embryo apposition/adhesion, followed by penetration and invasion. Through embryo penetration, the endometrial epithelial cell barrier is disrupted and remodeled by an unknown mechanism. We have previously developed an in vitro model for human embryo implantation employing the human choriocarcinoma cell line JAR and the human endometrial adenocarcinoma cell line Ishikawa. Using this model we have shown that stimulation with ovarian steroid hormones (17β-estradiol and progesterone, E2P4) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, enhances the attachment and adhesion of JAR spheroids to Ishikawa. In the present study we showed that the attachment and adhesion of JAR spheroids and treatment with E2P4 or SAHA individually induce the epithelial-mesenchymal transition (EMT) in Ishikawa cells. This was evident by up-regulation of N-cadherin and vimentin, a mesenchymal cell marker, and concomitant down-regulation of E-cadherin in Ishikawa cells. Stimulation with E2P4 or SAHA accelerated Ishikawa cell motility, increased JAR spheroid outgrowth, and enhanced the unique redistribution of N-cadherin, which was most prominent in proximity to the adhered spheroids. Moreover, an N-cadherin functional blocking antibody attenuated all events but not JAR spheroid adhesion. These results collectively provide evidence suggesting that E2P4- and implanting embryo-induced EMT of endometrial epithelial cells may play a pivotal role in the subsequent processes of human embryo implantation with functional control of N-cadherin. PMID:22174415
Reactivation of latent HIV-1 by new semi-synthetic ingenol esters
Energy Technology Data Exchange (ETDEWEB)
Pandeló José, Diego [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Bartholomeeusen, Koen [Department of Medicine, Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143-0703 (United States); Delveccio da Cunha, Rodrigo; Abreu, Celina Monteiro [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Glinski, Jan [PlantaAnalytica LLC, Danbury, CT 06810 (United States); Barbizan Ferreira da Costa, Thais; Bacchi Rabay, Ana Flávia Mello; Pianowski Filho, Luiz Francisco [Kyolab Laboratories, Valinhos, São Paulo 13273-105 (Brazil); Dudycz, Lech W. [Lex Company Research Laboratories, Shirley 01464, MA (United States); Ranga, Udaykumar [Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru 560064 (India); Peterlin, Boris Matija [Department of Medicine, Microbiology and Immunology, University of California at San Francisco, San Francisco, CA 94143-0703 (United States); Pianowski, Luiz Francisco [Kyolab Laboratories, Valinhos, São Paulo 13273-105 (Brazil); Tanuri, Amilcar [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil); Aguiar, Renato Santana, E-mail: santana@biologia.ufrj.br [Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902 (Brazil)
2014-08-15
The ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent HIV reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was more potent in reactivating latent HIV than known activators such as SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. ING B activated PKC isoforms followed by NF-κB nuclear translocation. As virus reactivation is dependent on intact NF-κB binding sites in the LTR promoter region ING B, we have shown that. ING B was able to reactivate virus transcription in primary HIV-infected resting cells up to 12 fold and up to 25 fold in combination with SAHA. Additionally, ING B promoted up-regulation of P-TEFb subunits CDK9/Cyclin T1. The role of ING B on promoting both transcription initiation and elongation makes this compound a strong candidate for an anti-HIV latency drug combined with suppressive HAART. - Highlights: • 3-caproyl-ingenol (ING B) reactivates latent HIV better than SAHA, ingenol 3,20-dibenzoate, TNF-α, PMA and HMBA. • ING B promotes PKC activation and NF-kB translocation to the nucleus. • ING B activates virus transcription of B and non-B subtypes of HIV-1. • ING B activates HIV transcription in infected primary resting CD4+ T cells. • ING B induces higher levels of P-TEFb components in human primary cells.
International Nuclear Information System (INIS)
Park, Ki-Cheong; Kim, Seung-Won; Park, Ji-Hyun
2011-01-01
Histone deacetylase (HDAC) is an attractive target for cancer therapy because it plays a key role in gene expression and carcinogenesis. N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA) is a novel synthetic HDAC inhibitor (HDACI) that shows better pharmacological properties than a known HDACI present in the human fibrosarcoma cell: suberoylanilide hydroxamic acid (SAHA). Here, we investigate the anti-cancer activity of HNHA against breast cancer both in vitro and in vivo. HNHA arrested the cell cycle at the G 1 /S phase via p21 induction, which led to profound inhibition of cancer cell growth in vitro. In addition, HNHA-treated cells showed markedly decreased levels of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor (HIF)-1α than SAHA and fumagillin (FUMA) when accompanied by increased histone acetylation. HNHA significantly inhibited tumor growth in an in vivo mouse xenograft model. HNHA-treated mice survived significantly longer than SAHA- and FUMA-treated mice. Dynamic MRI showed significantly decreased blood flow in the HNHA-treated mice, implying that HNHA inhibits tumor neovascularization. This finding was accompanied by marked reductions of proangiogenic factors and significant induction of angiogenesis inhibitors in tumor tissues. We have shown that HNHA is an effective anti-tumor agent in breast cancer cells in vitro and in breast cancer xenografts in vivo. Collectively, these findings indicate that HNHA may be a potent anti-cancer agent against breast cancer due to its multi-faceted inhibition of HDAC activity, as well as anti-angiogenesis activity. (author)
A review of the discovery of SM-like Higgs boson in H→ γγ decay ...
Indian Academy of Sciences (India)
Home; Journals; Pramana – Journal of Physics; Volume 87; Issue 3. A review ... Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, India; National Central University, No. 300 ... Proceedings of the International Workshop/Conference on Computational Condensed Matter Physics and Materials Science
Membrane Reflector Vertical Cavity Lasers at Near- and Midwave-Infrared
2014-05-30
independent broadband reflectors based on cross-stacked gratings, Optics Express, (04 2011): 9050. doi: 10.1364/OE.19.009050 Tapas Kumar Saha, Mingyu Lu... Mingyu Lu, Huiqing Zhai, Deyin Zhao, Weidong Zhou. Design of a compact grating coupler with controllable linewidths via transverse resonance and
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Suchandra Chakraborty. Articles written in Resonance – Journal of Science Education. Volume 17 Issue 8 August 2012 pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra ...
Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Journal of Chemical Sciences; Volume 119; Issue 2. Comparative photophysical behaviour of naphthalene-linked crown ethers and aza crown ethers of varying cavity dimensions. Subhodip Samanta Pinki Saha Sardar Shyam Sundar Maity Anirban Pal Maitrayee Basu Roy Sanjib Ghosh. Volume 119 Issue ...
New Fellows and Honorary Fellow
Indian Academy of Sciences (India)
Saha, Prof. Ajit Kumar Ph.D. (Calcutta and Toronto), FNA. Date of birth: 25 May 1925. Date of death: 27 April 1997. Specialization: Petrology, Geochemistry, Precambrian Geology and Environmental Geology Last known address: Emeritus Professor of Geology, Department of Geology, Presidency College, Calcutta 700 073.
Scientific Staff | ast.noao.edu
support (GMOS), Gemini archive support, NOAO LSST science working group, SCD/ANTARES Tucson Joan Najita ; quasars NOAO Diversity Co-Advocate, Gemini user support (GMOS) (also assigned NDO, see above) Tucson Knut Associate Scientist Quasar host galaxies Gemini user support (NIRI, GMOS) Tucson Abhijit Saha (Abi
Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor
2015-09-01
Center, Urology Habib , Amyn; UTSouthwestern Medical Center, Neurology & Neurotherapeutics Chen, Benjamin; UTSouthwestern Medical Center, Radiation...Tsong Hsieh 3,5,7 , Amyn A. Habib 4,5,6 , Benjamin Chen 1,4 and Debabrata Saha 1,4 1 Department of Radiation Oncology, 3 Department of Urology, 4
Mineral phosphate solubilizing bacterial community in agro-ecosystem
African Journals Online (AJOL)
Mineral phosphate solubilizing bacterial community in agro-ecosystem. N Saha, S Biswas. Abstract. The present communication deals with the assessment of phosphate solubilizing bacterial community structure across artificially created fertility gradient with regards to N, P and K status of soil in the experimental site.
Monticelli, Daniele, 1970-
2009-01-01
Itaalia keele korraldamisel ja uuendamisel osalenud teadlaste ja kirjanike retoorikast, argumenteerimise strateegiatest ja keelekorralduse teoreetilistest alustest, kõrvutades neid eesti keeleuuenduse analoogsete aspektidega
Introducing the Internet-based TOEFL test / Epp Kirss, Mare Roes
Kirss, Epp
2013-01-01
Internetipõhisest rahvusvaheliselt tunnustatud standardiseeritud inglise keele testist, mida nõutakse USA ülikoolidesse kandideerivatelt rahvusvahelistelt üliõpilastelt ning selle õpetamise kogemusest
В стиле абсента = In the style of absinthe / Оксана Осадчая
Осадчая, Оксана
2015-01-01
Julia Havanskaja uuest rõivakollektsioonist "Absinth". Absindi teemast maalikunstis, kirjanduses, filmikunstis. Charles Baudelaire luuletus "Les Fleurs du mal" ("Kurja lilled") vene ja inglise keeles
Männa, Krista
2005-01-01
16.-20. novembril toimus Tallinna Ülikooli esimese rahvusvahelise magistriõppekava "European Perspectives on Social Inclusion" (eesti keeles "Sotsiaalse kaasamise Euroopa perspektiivid") esimene õppesessioon
Kaks turgi eepost eesti keeles / Ott Kurs
Kurs, Ott, 1939-
2013-01-01
Arvustus: Manas : pärimus kangelasest : kirgiisi rahva eepos / [ümberjutustus ja runod: Peeter Ilus ; toimetaja ja järelsõna: Artur Laast ; illustraator Kristina Viin ; kujundaja Mart Anderson]. Ikla : Penikoorem, 2012
Kuidas uurida esimese ja teise keele omandamist?
Directory of Open Access Journals (Sweden)
Erika Matsak
2010-10-01
Full Text Available The main objective of the research is to compare the linguistic development of first (L1 and second language (L2 learners from a dual perspective: 1 stages of acquisition (young children - pre-schoolers - primary school pupils - basic school pupils - upper-secondary school students - adults and 2 levels of proficiency (A1 - A2 - B1 - B2 - C1 - C2. Th e intersection of these two coordinate systems forms the general framework on the basis of which one can describe the written and oral language use and linguistic development of L1 and L2 learners of Estonian performing similar communicative tasks. Th e results of the research should give an overview of the similarities and diff erences in the stages and proficiency levels of language acquisition in the L1 and L2. Th ey should help researchers understand in what order and in what manner language learners create and use new linguistic structures; whether L1 and L2 are acquired in parallel, and if yes, then to what extent this is so; what is the role of the frequency, transparency, grammaticality and acceptability of linguistic elements and (idiomatic constructions in language acquisition; and to what extent learners rely on rules or analogy in language acquisition.
"Kas siis selle maa keel..." / Ela Tomson
Tomson, Ela, 1945-
2003-01-01
Tähelepanekuid Brüsselis Euroopa Komisjoni korraldusel toimunud rahvusvaheliselt seminarilt, kus käsitleti vähemuskeelte staatust EL-i liikmes- ja liituvates riikides. Autori sõnul on Euroopas Eesti suhtes varasemast oluliselt rohkem mõistmist
Ladina keele õpikud ja sententsikogumikud / Ivo Volt
Volt, Ivo, 1975-
2000-01-01
Ka sententsikogumikest: V. Hromov. Dicta et proverbia Latina. Tallinn : Perioodika, 1997 ; 1001 ladina sententsi eesti vastetega. Tallinn : Valgus, 1997 ; K. Türk. Lendsõnade leksikon. Tallinn : Avita, 1998
Teise keel : dialoog ilma kommunikatsioonita / Urve Eslas
Eslas, Urve, 1972-
2005-01-01
Emmanuel Levinasist kui semiootikavastasest mõtlejast ning semiootikast kui vägivallateadusest. Samuti tema arusaamast kommunikatsioonist, mis ei ole ainult informatsioonivahetus vaid ka pidev ütlemine ja ümberütlemine
Eesti keel eestlaste emotsioonidest / Haldur Õim
Õim, Haldur, 1942-
2004-01-01
Arvustus: Vainik, Ene. Lexical knowledge of emotions: the structure, variability and semantics of the Estonian emotion vocabulary. Tartu : Tartu University Press, 2004. (Dissertationes linguisticae Universitatis Tartuensis ; 5)
Ilmus kogumik eesti naiste elulugusid inglise keeles
2006-01-01
Carrying Linda's stones : an anthology of Estonian women's life stories / editors: Suzanne Stiver Lie, Lynda Malik, Ilvi Jõe-Cannon, Rutt Hinrikus ; foreword by H.E. Aldona Wos. Tallinn : Tallinn University Press, 2006. Sisaldab Elin Toona jt. elulugusid. Vt. ka SL Õhtuleht, 30. sept., lk. 27
An analytical excitation model for an ionizing plasma
Mullen, van der J.J.A.M.; Sijde, van der B.; Schram, D.C.
1983-01-01
From an analytical model for the population of high-lying excited levels in ionizing plasmas it appears that the distribution is a superposition of the equilibrium (Saha) value and an overpopulation. This overpopulation takes the form of a Maxwell distribution for free electrons. Experiments for He
Indian Academy of Sciences (India)
mathematical, and social sciences. ... The themes explored at the Berlin meeting ranged from studies of complex networks to extreme events in ... Saha and coworkers have used recurrence plots to characterize natural circulation loops that are of importance in passive thermal management devices, while Tadic, Andjelkovic ...
An analytical excitation for an ionizing plasma
Mullen, van der J.J.A.M.; Sijde, van der B.; Schram, D.C.
1983-01-01
From an analytical model for the population of high-lying excited levels in ionizing plasmas it appears that the distribution is a superposition of the equilibrium (Saha) value and an overpopulation. This overpopulation takes the form of a Maxwell distribution for free electrons. Experiments for He
Involution symmetries and the PMNS matrix
Indian Academy of Sciences (India)
Palash B Pal
2017-10-09
Oct 9, 2017 ... 1Saha Institute of Nuclear Physics, Block-AF, Sector-1, Bidhan Nagar, Kolkata 700 064, India ... paper [3] we take the third assumption in addition, and try to find symmetries ..... a finite subgroup of it that can fit the bill. We make ...
Indian Academy of Sciences (India)
Bhabha And His Magnificent. Obsessions. G Venkataraman. Universities Press India Ltd. Orient Longman Ltd. 1994, Rs.85. The Many Phases Of Matter. G Venkataraman. Universities Press India Ltd. Orient Longman Ltd. 1991, Rs.60. Saha And His Formula. G Venkataraman. Universities Press India Ltd. Orient Longman ...
Resonance – Journal of Science Education | Indian Academy of ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Dipankar Nandi. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Asma Ahmed. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan Shwetha ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Shwetha Shivaprasad. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 6 June 2009 pp 610-621 General Article. The Major Players in Adaptive Immunity - Cell-mediated Immunity · Asma Ahmed Banishree Saha Anand Patwardhan ...
Indian Academy of Sciences (India)
Home; Journals; Resonance – Journal of Science Education. Shwetha Shivprasad. Articles written in Resonance – Journal of Science Education. Volume 14 Issue 5 May 2009 pp 455-471 General Article. The Major Players in Adaptive Immunity - Humoral Immunity · Asma Ahmed Banishree Saha Anand Patwardhan ...
Resonance – Journal of Science Education | News
Indian Academy of Sciences (India)
pp 768-778 General Article. Dissymmetry and Asymmetry - A Hopeless Conflict in Chemical Literature · Chandan Saha Suchandra Chakraborty · More Details Fulltext PDF. pp 779-790 Classroom. Analysing Spherical Aberration in Concave Mirrors · Ranjit Konkar · More Details Fulltext PDF. pp 791-796 Research News.
Emergency separation of a xipho-omphalopagus twin in a ...
African Journals Online (AJOL)
Emergency separation of a xipho-omphalopagus twin in a developing country. RM Shukla, B Mukhopadhyay, KC Mandal, K Saha, D Roy, PP Mukherjee. Abstract. Female conjoined twins (thoraco-omphalopagus) were delivered by emergency caesarean section in a private nursing home. On examination, one of the twins ...
Indian Academy of Sciences (India)
Home; Journals; Bulletin of Materials Science. Tushar Jana. Articles written in Bulletin of Materials Science. Volume 32 Issue 5 October 2009 pp 507-514 Polymers. Functionalization of hydroxyl terminated polybutadiene with biologically active fluorescent molecule · R Murali Sankar Subhadeep Saha K Seeni Meera Tushar ...
Pramana – Journal of Physics | Indian Academy of Sciences
Indian Academy of Sciences (India)
APARNA SAHA1 B TALUKDAR1 UMAPADA DAS2 SUPRIYA CHATTERJEE3. Department of Physics, Visva Bharati University, Santiniketan 731 235, India; Department of Physics, Abhedananda College, Sainthia 731 234, India; Department of Physics, Bidhannagar College, EB-2, Sector-1, Salt Lake, Kolkata 700 064, ...
Bakri, Ridla; Parikesit, Arli Aditya; Satriyanto, Cipta Prio; Kerami, Djati; Tambunan, Usman Sumo Friend
2014-01-01
Histone deacetylase (HDAC) has a critical function in regulating gene expression. The inhibition of HDAC has developed as an interesting anticancer research area that targets biological processes such as cell cycle, apoptosis, and cell differentiation. In this study, an HDAC inhibitor that is available commercially, suberoyl anilide hydroxamic acid (SAHA), has been modified to improve its efficacy and reduce the side effects of the compound. Hydrophobic cap and zinc-binding group of these compounds were substituted with boron-based compounds, whereas the linker region was substituted with p-aminobenzoic acid. The molecular docking analysis resulted in 8 ligands with ΔG binding value more negative than the standards, SAHA and trichostatin A (TSA). That ligands were analyzed based on the nature of QSAR, pharmacological properties, and ADME-Tox. It is conducted to obtain a potent inhibitor of HDAC class II Homo sapiens. The screening process result gave one best ligand, Nova2 (513246-99-6), which was then further studied by molecular dynamics simulations. PMID:25214833
Alternative approach to the surface-excitation model
International Nuclear Information System (INIS)
Krohn, V.E.
1981-01-01
Although the development of the surface-excitation model of sputtered-ion emission involved a detailed description of the ionization process, one can arrive at the same result by assuming an equilibrium treatment, e.g. the Saha-Langmuir equation, with the temperature falling as the collision casade develops. This suggests that, even if situations are found where the surface-excitation model is successful, it does not follow that the original detailed description of the ionization process is correct. Nevertheless, the surface-excitation model does contain an interesting new idea which should not be overlooked, i.e. that atoms sputtered during the early stages of a collision cascade will be relatively energetic, and to the extent that the Saha-Langmuir equation has some applicability, will have a probability of positive ionization which will be low for atoms of low ionization potential (I phi), relative to lower-energy atoms emitted during the later stages of the collision cascade. The extended abstract will discuss recent experimental results
EREĞLİ (KONYA) İLÇESİNDE MEYVECİLİK
TAPUR, TAHSİN; BOZYİĞİT, RECEP
2013-01-01
ÖZETAraştırma Sahası, İç Anadolu Bölgesi’nin güneydoğusunda yer alır. Ereğli ilçesidir. Bu çalışmanın amacı, Ereğli’de meyveciliğin dağılımını, üretimini ve gelişimini ortaya koymaktır. Araştırmanın ilk aşamasında konu ile ilgili literatür incelenmiştir. Daha sonra çeşitli tarihlerde (Eylül 2008 veTemmuz 2009) arazi incelemeleri yapılmıştır. Saha çalışması ile elde edilen bilgiler, literatür ve SWOT/GZFT analiz yöntemi ile değerlendirilmiştir.Çalışma alanında meyveciliğin gelişmesi üzerinde f...
Directory of Open Access Journals (Sweden)
Ertan ENGİN
2012-07-01
Full Text Available Karşılaştırmalı edebiyat çalışmaları içinde bir alt disiplin, yan dal olarak ortaya çıkan ve zaman geçtikçe araştırmacılar tarafından daha çok ilgi gören imagoloji, toplumların birbirlerini nasıl gördüklerini inceleyen ve bunu da çoğunlukla/öncelikle kendisi için en elverişli malzemeyi sağlayacak edebiyat eserleri üzerinden gerçekleştiren bir araştırma sahasıdır. Bu yazıda söz konusu araştırma sahasının kökeninde yer alan ‘imaj’ kavramı ile birlikte, imagolojinin kapsam ve metodolojisinde dikkatimizi çeken bazı noktalara değinilmiştir.
DIALANG and pilot testing / Sirje Jakobson
Jakobson, Sirje
2002-01-01
Hollandi haridus-, kultuuri- ja teadusministeeriumi poolt keelteaasta raames korraldatud Euroopa keeleprojekte tutvustavast konverentsist ning kultuuri- ja haridusprojektist DIALANG, mis koostab diagnostilisi teste 14 euroopa keeles
Jumalaga, ainsus! : (Postmodernismi väljakutse eesti kirjandusele ja kriitikale) / Rein Veidemann
Veidemann, Rein, 1946-
1995-01-01
Ka Harald Peebu artiklist 'Arvustaja teeristil' (Keel ja Kirjandus, 1993, nr. 10), postmodernismi klassiku Jacques Derrida seisukohtadest, tema terminist 'différance' - 'siirdus' ja kirjanduskriitikast
Juri Lotmani kunstiteksti lugemise õpetus / Ülle Pärli
Pärli, Ülle
2007-01-01
Ilukirjanduslike tekstide kasutamisest vene keele õpetamisel. Kirjandusteksti analüüsi põhimõtetest Juri Lotmani monograafiates. Lotmani osalusel koostatud kirjandusõpikutest ja kirjanduslikust lugemikust
Scott, George H.; Ingle, James C.; McCane, Brendan; Powell, Charles L.; Thunell, Robert C.
2015-01-01
Truncorotalia crassaformis has been identified in Pliocene-Holocene assemblages globally but there has been little analysis of specimens from its type locality at Lomita Quarry, California. This has led to confusion about some diagnostic criteria, particularly the presence of a peripheral keel. To better understand variation specimens are studied from the type locality (Pleistocene, c. 400–600 ka), supplemented by material from a plankton trap in Cariaco Basin and from ODP 925, Ceara Rise (Pliocene, c. 4.3 Ma). The damaged holotype has a weak topographic ridge (keel) at the periphery of early chambers of the outer whorl. Several well-preserved specimens have a keel on all chambers of the whorl. Encrustation obscures the periphery on some and masks shell shape. Several outliers in a morphometric analysis of axial shape have distinctive discoidal outlines but ventroconical (cone-like) forms are common. Lomita Marl was deposited on a sheltered, shallow shelf in Chron 1. Foraminifera reworked from the unconformably underlying Repetto Siltstone are present. Specimens resembling the holotype are very rare and often damaged. Morphological disparity is high. It is unlikely that an autochthonous population was sampled. The weak peripheral keel present on some living specimens from Cariaco Basin is built incrementally by a thin featureless calcitic veneer deposited between the morphogenesis of each chamber. The process progressively obscures pores in the primary wall. Its earliest stages have been misidentified as a poreless zone. Ventroconical form is weak in the Ceara Rise Pliocene specimens and is distinguishable from the Cariaco sample. There is only a veneer at the periphery. Although the study does not provide a population-based diagnosis of T. crassaformis it indicates that the name should not be applied to early Pliocene forms.
International Nuclear Information System (INIS)
Hong, Jae-Taek; Takigaya, Tomoyuki; Sugisaki, Keizo; Orias, A.A.E.; Inoue, Nozomu; An, H.S.
2011-01-01
Two recent novel techniques of occipital fixation are the occipitoatlantal (C0-C1) transarticular screw technique and the direct occipital condyle screw technique. The present study evaluated and compared the biomechanical stability of the direct occipital condyle screw and C0-C1 transarticular screw with the established method for craniocervical spine fixation using the midline occipital keel screw and C1 lateral mass screw. Morphometric evaluation of the occipital condyle and the hypoglossal canal was performed to avoid hypoglossal nerve injury during the screw placement. Thirteen recently frozen cadaveric specimens were used. The occipital condyle anatomy and the hypoglossal canal dimension were measured using reconstructed computed tomography images. Insertion torque and pullout strength were evaluated to compare the midline occipital keel screw, C0-C1 transarticular screw, C1 lateral mass screw, and direct occipital condyle screw. The dimensions of the occipital condyle allow use of a 3.5 or 4.0-mm diameter screw. Mean pullout strength was 1619.6 N for the midline occipital keel screw, 870.7 N for the C0-C1 transarticular screw, 707.0 N for the C1 lateral mass screw, and 431.7 N for the direct occipital condyle screw. Mean insertion torque was 0.55 Nm for the midline occipital keel screw, 0.32 Nm for the C0-C1 transarticular screw, 0.14 Nm for the C1 lateral mass screw, and 0.11 Nm for the direct occipital condyle screw. The condylar anatomy allows direct insertion of the occipital condyle screw and C0-C1 transarticular screw. These techniques are suitable options for the treatment of craniovertebral junction instabilities in selected patients. (author)
Rahvusvahelise õiguse õõnes universaalsus / Hent Kalmo
Kalmo, Hent, 1979-
2017-01-01
Võrdleva rahvusvahelise õiguse projektist, rahvusvahelise õiguse alastest argumentidest ja eripäradest tõlgendamisel. Eesmärkide kaitsmise keelest unversaalses õiguslikus keeles ja tõlgenduste lahknemisest
Lange, Felix
2017-01-01
Rahvusvahelistest lepingutest loobumisest ja parlamendi kaasamisest otsustusprotsessi Saksa põhiseaduse artikli 59 tähenduses; Suurbritannia ja Lõuna-Aafrika ülemkohtute lahenditest. Kokkuvõte inglise keeles
Läänemeresoome eeposte ümarlaud / Marin Laak
Laak, Marin, 1964-
2005-01-01
F. R. Kreutzwaldi "Kalevipoja" täisteksti esmailmumise puhul prantsuse keeles korraldas Prantsuse Kultuuri Instituut ümarlaua teemal """Kalevipoeg" ja "Kalevala" : rahvuseeposte tõlkimine ja retseptsioon"
Ameerikasse õpetama / Tiina Tuuling
Tuuling, Tiina
2007-01-01
Nõo Reaalgümnaasiumi ja Nõo Põhikooli inglise keele õpetaja Tiina Tuulingu töötamisest õpetajana USAs Pennsylvania osariigis Haverfordi Põhikoolis Fulbrighti õpetajate vahetusprogrammi raames
Vana praavusk Roth 225 / Milvi Hirvlaane
Hirvlaane, Milvi, 1936-
2008-01-01
Baltisaksa päritolu eesti vaimulikust, koolitegelasest ja luuletajast Johann Philipp von Rothist, tema osast Eesti kultuuriloos, võru keele arendamises, talurahvaseaduse ettevalmistamises ja paljus muus
On Munduruku, a new Theraphosid genus from Oriental Amazonia (Araneae, Mygalomorphae
Directory of Open Access Journals (Sweden)
Laura T. Miglio
2013-06-01
Full Text Available Munduruku gen. nov. is proposed for the type species Munduruku bicoloratum sp. nov., from Juruti and Santarém, Pará, Brazil. The main diagnostic character of Munduruku gen. nov. is the presence of a subapical, lanceolate keel on the male palpal bulb, which is unique among the basal taxa of Theraphosinae with type III-IV urticating setae. The female spermathecae consist of two spheroid receptacles with funnel-shaped necks, each of which bears a sclerotized area. In both sexes, the abdomen is remarkably patterned, an uncommon feature in adults of New World theraphosids. Both the bulbus lanceolate keel and the abdominal color pattern are hypothesized as synapomorphies of the genus.
Indian Academy of Sciences (India)
Kanishka Biswas
(Solid state inorganic chemistry). (Metal chalcogenide chemistry). Manoj K. Jana. Satya N. Guin. Ananya Banik. Subhajit. Roychowdhury. Manisha Samanta Ekashmi. Rathore. Sujoy Saha. Thermoelectrics. Guin et al. Energy Environ. Sci., 2013, 6, 2603. Guin et al. J. Mater. Chem. A 2014, 2, 4324. Guin, et al. J. Am. Chem.
Pramana – Journal of Physics | Indian Academy of Sciences
Indian Academy of Sciences (India)
Effects of non-local thermodynamic equilibrium (non-LTE) condition on emission and hydrodynamics of typical inertial confinement fusion (ICF) plasmas are studied. The average degree of ionization at high temperatures is seen to be much lower compared to the values obtained from Thomas–Fermi scaling or Saha ...
Weather Service NWS logo - Click to go to the NWS home page Climate Forecast System Home News Organization Web portal to all Federal, state and local government Web resources and services. The NCEP Climate when using the CFS Reanalysis (CFSR) data. Saha, Suranjana, and Coauthors, 2010: The NCEP Climate
Journal of Earth System Science | Indian Academy of Sciences
Indian Academy of Sciences (India)
pp 125-142. Kinematics of large scale asymmetric folds and associated smaller scale brittle-ductile structures in the Proterozoic Somnur Formation, Pranhita - Godavari valley, south India · Gautam Ghosh Dilip Saha · More Details Abstract Fulltext PDF. The development of structural elements and finite strain data are ...
Sadhana | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Sadhana. Ankit Shrivastava. Articles written in Sadhana. Volume 40 Issue 3 May 2015 pp 769-785 Section I – Fluid Mechanics and Fluid Power (FMFP). Suppression of vortex shedding around a square cylinder using blowing · Arun K Saha Ankit Shrivastava · More Details Abstract Fulltext PDF.
Ionizing Shocks in Argon. Part 1: Collisional-Radiative Model and Steady-State Structure (Preprint)
2010-09-09
absorption oscillator strength is given by fabsij = gj gi Aji 3γ . (43) Contributions to the parameter γ have been assumed to result from a combination of...discretization, the Saha temperatures of the higher states (green, red and blue solid curves) overshoot Te and relaxes with Th, indicating over
Short Communication: Prevalence of hypertension and variation of ...
African Journals Online (AJOL)
Short Communication: Prevalence of hypertension and variation of blood pressure with age among adolescents in Chetla, India. I Saha, B Paul, A Dasgupta. Abstract. This community-based cross-sectional study was carried out to determine the prevalence of hypertension and variation of blood pressure with age among ...
Indian Academy of Sciences (India)
Mondal, Prof. Naba Kumar Ph.D. (Bombay) D.Sc. (h.c.), FNA, FNASc, FTWAS. Date of birth: 11 March 1951. Specialization: Experimental Particle Physics, Accelerator-based Particle Physics and Neutrino Physics Address: Raja Ramanna Fellow, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, W.B.
Is the Human Development Index (HDI) of the United Nations ...
African Journals Online (AJOL)
Is the Human Development Index (HDI) of the United Nations Development Programme (UNDP) a relevant indicator? Jean Claude Saha. Abstract. No Abstract. African Journal of Economic Policy Vol. 12(1) 2005: 1-27. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.
Measurement of the argon plasma temperature by use of pyrometer
International Nuclear Information System (INIS)
Wang Fanhou; Jing Fuqian
2002-01-01
The author describes in detail how to use pyrometer to measure the plasma temperature. The temperatures of shock-generated argon plasmas are given in the present work. Measured results of temperature-pressure curve are compared with calculated results using Saha-Debye-Huckel model, which are in good agreement
Journal of Earth System Science | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Journal of Earth System Science. Anup Saha. Articles written in Journal of Earth System Science. Volume 125 Issue 4 June 2016 pp 885-895. Effect of irregularity on torsional surface waves in an initially stressed anisotropic porous layer sandwiched between homogeneous and non-homogeneous half- ...
DEFF Research Database (Denmark)
Thanh Tung, Truong; Oanh, Dao Thi Kim; Dung, Phan Thi Phuong
2013-01-01
Results from clinical studies have demonstrated that inhibitors of histone deacetylase (HDAC) enzymes possess promise for the treatment of several types of cancer. Zolinza(®) (widely known as SAHA) has been approved by the FDA for the treatment of T-cell lymphoma. As a continuity of our ongoing...
from First-principles study to Materials Modeling Tanusri Saha ...
Indian Academy of Sciences (India)
MOTIVATION. • Novel materials are key to new technologies. • Modeling is playing an ever increasing role in the search for new materials. • The chemistry controls the physical properties (e.g. electrical, magnetic, and optical properties) of materials. At the root of all are the Electrons! . – p.3/25 ...
Inglise roosidega Pariisis / Romi Erlach
Erlach, Romi, 1977-
2003-01-01
Madonna lasteraamat "The English roses" ("Inglise roosid") ilmub 100 riigis ja 30 keeles; esitlus toimus 15. sept. Pariisis; sisaldab raamatuesitluse pressikonverentsi huvitavamaid küsimusi ja vastuseid
2010-01-01
Analüüsitakse ametiasutustesse tulnud telefonikõnesid, eesmärgiga arendada intelligentset kasutajaliidest, mis võimaldaks suhelda andmebaasiga eesti keeles. Täpsemalt keskendutakse dialoogiakti direktiivsetele naabruspaaridele
Võimsad vahendid käitumise haldamiseks klassiruumis / Lauri Tankler
Tankler, Lauri
2012-01-01
Eduko õpetajakoolituse õppejõududele suunatud meistriklasside sarjast, mille esimeseks külalisesinejaks oli Austraalia haridusnõustaja professor Bill Rogers, kes tutvustas ka oma eesti keeles ilmunud raamatut
Uue oskuse võlu / Helen Talalaev
Talalaev, Helen
2009-01-01
Tutvustatakse kirjastuse TEA väljaantud õppekomplekte: Tomalin, Barry. Westminster English. Tallinn : TEA Kirjastus, 2009 ; Mangus, Inga. Vene keele õpik : algajale ja taasalustajale. Tallinn : TEA Kirjastus, 2008
Kulka lemmikud 2007 / Kalev Kesküla
Kesküla, Kalev, 1959-2010
2008-01-01
Eesti Kultuurikapitali aastapreemia said 17. saj. Tartu juhuluule kogumiku "O Dorpat, urbs addictissima musis" koostajad Kristi Viiding, Jana Orion, Janika Päll (Tallinn : Eesti Keele Sihtasutus, 2007)
Playing with Gombrowicz / Grzegorz Janikowski
Janikowski, Grzegorz
2004-01-01
Ka E. Nüganeni lavastatud W. Gombrowiczi "Laulatusest" Toruni teatri Teatr im. Horzycy esituses 9. rahvusvahelisel festivalil "Theatre Confrontations" Lublinis (6.-10. okt. 2004). Paralleeltekst prantsuse keeles
Milan Kundera poeediparukaga faun / Kärt Hellerma
Hellerma, Kärt, 1956-
1996-01-01
Arvustus: Kundera, Milan. Surematus. Tln. : Monokkel, 1995. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 176-179
Applying theory of constraints in tactical and strategic management / Kalev Kaarna, Mait Miljan
Kaarna, Kalev
2002-01-01
Bibliogr. lk. 86-87. - Kokkuvõte eesti keeles lk. 87. Piirangute teooria kasutamise vajadusest ja võimalustest. Piirangute juhtimisest pikas perspektiivis ning sellel põhinevast strateegilisest juhtimisest. Tabelid
2004-01-01
Riigikohtu lahendi 3-4-1-20-04 (Vabariigi Presidendi taotlus kontrollida Elamuseaduse ja Eesti Vabariigi omandireformi aluste seaduse § 12-1 muutmise seaduse vastavust Põhiseadusele) tekst inglise keeles
Carlo Ginzburg: anomaalia viitab normile / intervjueerinud Marek Tamm
Ginzburg, Carlo, 1939-
2014-01-01
Intervjuu itaalia ajaloolase Carlo Ginzburgiga tema raamatu "Ükski saar pole saar : neli pilguheitu inglise kirjandusele globaalsest vaatenurgast" eesti keeles ilmumise puhul. Teos ilmus Tallinna Ülikooli Kirjastuses
Grammatika soome-eesti suursõnaraamatus / Ülle Viks
Viks, Ülle
2004-01-01
Võimalustest leida grammatilisi andmeid sõnastikus: Soome-eesti suursõnaraamat=Suomi-viro suursanakirja. 1. A-Q ; 2. R-Ö. Tallinn : Eesti Keele Instituut ; Helsinki : Kotimaisten kielten tutkimuskeskus, 2003
Prezident ukazal na problemõ prepodavanija estonskogo jazõka v russkihh shkolahh
2002-01-01
President eesti keele õpetamisest vene koolides. Pealk. ajalehes Sillamjaeskii Vestnik (2002/Feb/2): "Prepodavanije estonskogo jazõka v russkihh shkolahh stalkivajetsja s rjadom problem, trebujushtshihh reshenija", lk. 1
[Musikwissenschaftliche Literatur] / Kristel Pappel
Pappel, Kristel, 1961-
1999-01-01
Tutvustus: Urve Lippus (toim.). Music history writing and national culture. Proceedings of a seminar : Tallinn, Detsember 1-3, 1995. Eesti muusikaloo toimetised 1. Tallinn : Eesti Keele Instituut, 1995
Indrek Treufeldti kaks elu / intervjueerinud Tiia Nightingale
Treufeldt, Indrek, 1969-
2014-01-01
Intervjuu telesaate "Kahekõne" saatejuhi ning doktorikraadiga teadlase ja Balti Filmi- ja Meediakooli õppejõu Indrek Treufeldtiga telesaate ja teaduse tegemisest, Eesti ja maailma probleemidest, eesti keele tulevikust
Sadhana | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Sadhana. Saurabh Aggarwal. Articles written in Sadhana. Volume 39 Issue 4 August 2014 pp 843-858. Give-and-take based peer-to-peer content distribution networks · Saurabh Aggarwal Joy Kuri Chandan Saha · More Details Abstract Fulltext PDF. Content Distribution Networks (CDNs) are widely used to ...
Indian Academy of Sciences (India)
Administrator
N MONDAL, M K SAHA, B BAG and S MITRA. Department of Chemistry, Jadavpur University, Calcutta 700 032, India. The chemistry of several bimetallic assemblies has developed recently due to their variable magnetic properties 1. Among them a cyanide system based on prussian blue and its analogues is particularly ...
Pramana – Journal of Physics | Indian Academy of Sciences
Indian Academy of Sciences (India)
Home; Journals; Pramana – Journal of Physics; Volume 68; Issue 3. Effects of barrier fluctuation on the tunneling dynamics in the presence of classical chaos in a mixed quantum-classical system. Aparna Saha Bidhan Chandra Bag Pranab Sarkar. Research Articles Volume 68 Issue 3 March 2007 pp 377-387 ...
Journal of Earth System Science | Indian Academy of Sciences
Indian Academy of Sciences (India)
pp 1421-1440. Simultaneous estimation of earthquake source parameters and crustal value from broadband data of selected aftershocks of the 2001 7.7 Bhuj earthquake · A Saha S Lijesh P Mandal · More Details Abstract Fulltext PDF. This paper presents the simultaneous estimation of source parameters and crustal ...
Lost Talent? The Occupational Ambitions and Attainments of Young Australians
Sikora, Joanna; Saha, Lawrence J.
2011-01-01
Given ongoing interest in increasing productivity and participation in the workforce, understanding when talent is lost is a useful exercise. The term "lost talent" describes the underutilisation or wastage of human potential. Focusing on young people, Sikora and Saha define lost talent as occurring when students in the top 50% of…
Quarkonia production at forward rapidity in Pb+Pb collisions at ...
Indian Academy of Sciences (India)
2012-10-02
Oct 2, 2012 ... Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata 700 064, India .... However, the midrapidity values at 200 GeV. *> part.
Indian Academy of Sciences (India)
The National Conference on X-Ray Fluorescence, XRF-2010, held at Saha Institute of. Nuclear Physics, Kolkata from January 12 to 15, 2010, was organized with the intention of presenting the latest developments in the field of X-Ray Fluorescence and to stimulate fruitful discussions amongst the researchers in our country.
Journal of Chemical Sciences | Indian Academy of Sciences
Indian Academy of Sciences (India)
Nickel(II) complexes having Imidazol-2-ylidene-N′-phenylurea ligand in the coordination sphere – syntheses and solid state structures · Kishor Naktode Abhinanda Kundu Sudeshna Saha Hari Pada Nayek Tarun K Panda · More Details Abstract Fulltext PDF. We report the syntheses and structural studies of two nickel(II) ...
Liberalismusest / Heido Vitsur
Vitsur, Heido, 1944-
2008-01-01
Liberalismist seoses eesti keeles ilmunud Ludwig von Misese raamatuga "Liberalism". Artikli autor oletab, et lähiaastail ei oota meid ees liberalismi positsioonide tugevnemine, vähemalt majanduses mitte
Rooma põleb, kirjanik mängib viiulit / Kärt Hellerma
Hellerma, Kärt, 1956-
1996-01-01
Arvustus: Orwell, George. Valaskala kõhus. Tln.: Vagabund, 1995. Ilmunud ka kogumikus: Hellerma, Kärt. Kohanenud kirjandus : valik kirjanduskriitikat 1987-2006. Eesti Keele Sihtasutus : Tallinn, 2006. Lk. 173-175
Reading of Beowulf / Ilmar Anvelt
Anvelt, Ilmar, 1949-
2013-01-01
Kirjandusfestivali Prima Vista raames toimunud anglo-saksi eepose täies mahus ettelugemisest nii vanainglise keeles kui eestikeelses tõlkes TÜ inglise filoloogia osakonna õppejõudude ja tudengite poolt
Galicia ja galeegid / Arturo Casas Vales ; interv. Jüri Talvet
Vales, Arturo Casas
2002-01-01
Galiitsia kirjandusteoreetiku ja luuletaja ja A. Casas Valesi (sünd. 1958) arvamus eesti ja galeegi kirjanduse ning kultuuri sarnasustest ja erinevustest, galeegi keele sotsiaalsest kohast ja kirjanduse arengust
Zaicz, Gábor
2000-01-01
Ungari arstiteadlase Sámuel Gyamathi ladinakeelsest uurimusest "Affinitas linguae Hungaricae cum linguis Fennicae originis grammaticae demonstrata" ("Grammatiline tõestus ungari keele ja soome päritolu keelte suguluse kohta")
Ameeriklased vedasid keelelaagrit / Silvi Kanošina
Kanošina, Silvi
2007-01-01
Tõstamaa Keskkooli inglise keele õpetaja Anneli Võso kutsel oli California Brentwood Golden Hills Community Church esindus neli päeva Tõstamaal, et anda siinseile noortele võimalus keelt praktiseerida
Eesti presidendi külaskäik tõi koolikoridoridesse elektrivalguse / Eve Heinla
Heinla, Eve, 1966-
2002-01-01
President Arnold Rüütel koos abikaasaga külastasid Krimmis Krasnodarka Eesti kooli. Aleksandrovka keskkooli eesti keele õpetaja Merge Simmuli kommentaarid. Riigivisiit Ukraina Vabariiki 14.-18. 10. 2002
1994-01-01
Riigikohtu lahendi III-4/A-1 (Vabariigi Presidendi poolt põhiseaduse § 107 korras esitatud ettepaneku, tunnistada Riigivapi seadus põhiseadusega vastuolus olevaks, läbivaatamine) tekst inglise keeles
Tundekausatiivikonstruktsioon eesti moodi / Liina Lindström
Lindström, Liina, 1973-
2012-01-01
Käsitletakse kogejakonstruktsiooni, milles kogeja on markeeritud nagu grammatiline objekt ja stiimul nagu grammatiline subjekt. Konstruktsiooni vaadeldakse teiste keelte taustal, et välja selgitada eesti keeles toimunud muutusi