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Sample records for sah domain extends

  1. AL SAHLI, AA; OKOLI, JU

    African Journals Online (AJOL)

    ADOWIE PERE

    bioline.org.br/ja. The Use of Soil Palynomorphs in Forensics. *. 1. ABDULRAHAMAN, AA;. 2. AL SAHLI, AA;. 1. OKOLI, JU. 1Applied Plant Anatomy and Wood Technology Laboratory, Department of Plant Biology, University of Ilorin, Ilorin, Nigeria.

  2. Ecological Automation Design, Extending Work Domain Analysis

    NARCIS (Netherlands)

    Amelink, M.H.J.

    2010-01-01

    In high–risk domains like aviation, medicine and nuclear power plant control, automation has enabled new capabilities, increased the economy of operation and has greatly contributed to safety. However, automation increases the number of couplings in a system, which can inadvertently lead to more

  3. Extending the Effective Ranging Depth of Spectral Domain Optical Coherence Tomography by Spatial Frequency Domain Multiplexing

    Directory of Open Access Journals (Sweden)

    Tong Wu

    2016-11-01

    Full Text Available We present a spatial frequency domain multiplexing method for extending the imaging depth range of a spectral domain optical coherence tomography (SDOCT system without any expensive device. This method uses two galvo scanners with different pivot-offset distances in two independent reference arms for spatial frequency modulation and multiplexing. The spatial frequency contents corresponding to different depth regions of the sample can be shifted to different frequency bands. The spatial frequency domain multiplexing SDOCT system provides an approximately 1.9-fold increase in the effective ranging depth compared with that of a conventional full-range SDOCT system. The reconstructed images of phantom and biological tissue demonstrate the expected increase in ranging depth. The parameters choice criterion for this method is discussed.

  4. Extending the Finite Domain Solver of GNU Prolog

    NARCIS (Netherlands)

    Bloemen, Vincent; Bloemen, Vincent; Diaz, Daniel; van der Bijl, H.M.; Abreu, Salvador; Ströder, T.; Swift, T.

    This paper describes three significant extensions for the Finite Domain solver of GNU Prolog. First, the solver now supports negative integers. Second, the solver detects and prevents integer overflows from occurring. Third, the internal representation of sparse domains has been redesigned to

  5. Extended HSR/CARD domain mediates AIRE binding to DNA

    Energy Technology Data Exchange (ETDEWEB)

    Maslovskaja, Julia, E-mail: julia.maslovskaja@ut.ee; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt

    2015-12-25

    Autoimmune regulator (AIRE) activates the transcription of many genes in an unusual promiscuous and stochastic manner. The mechanism by which AIRE binds to the chromatin and DNA is not fully understood, and the regulatory elements that AIRE target genes possess are not delineated. In the current study, we demonstrate that AIRE activates the expression of transiently transfected luciferase reporters that lack defined promoter regions, as well as intron and poly(A) signal sequences. Our protein-DNA interaction experiments with mutated AIRE reveal that the intact homogeneously staining region/caspase recruitment domain (HSR/CARD) and amino acids R113 and K114 are key elements involved in AIRE binding to DNA. - Highlights: • Promoter and mRNA processing elements are not important for AIRE to activate gene expression from reporter plasmids. • AIRE protein fragment aa 1–138 mediates direct binding to DNA. • Integrity of the HSR/CARD domain is needed for AIRE binding to DNA.

  6. Extending conceptual understanding: How interprofessional education influences affective domain development.

    Science.gov (United States)

    Stephens, Melanie; Ormandy, Paula

    2018-01-25

    Interprofessional learning (IPL) can influence affective domain development of students through teaching activities that facilitate learning with, from, and about other professions. Current quantitative evidence offers limited explanation of how this learning is achieved within IPL programmes. This article tests a conceptual framework drawn from theories on IPL and affective domain development (attitudes, values, and behaviours) to explain what works for whom, when, and in what circumstances. The objectives of the study were twofold: to evaluate the impact of the IPL programme on the student's attitudes and values, and to identify behaviour changes in clinical practice towards interprofessional working. Using an action research approach, based in practice, an IPL programme was delivered over 6 weeks. Students from five professions, nursing, radiography, physiotherapy, social work, and podiatry (n = 63), participated over the two action research cycles and in semi-structured focus groups (n = 37). The recorded personal experiences of the IPL activities on the students were examined in relation to the type of activity; impact on the affective domain of learning (attitude, value, or behaviour) and self-reported outcome on application to their practice. Modification in affective domain development was measured to identification or internalisation stage for 30 of the students. Self-reported outcomes on application to practice included direct impact on patient care, personal resilience building, improved communication, and ability to challenge practice. This article presents a conceptual framework not evident in current research, in regard to what IPL works for whom, in what circumstances, and when. IPL activities that address a personal reward or incentive and are delivered over four weeks, imitating 'circles of care,' that explore self-assessment, team building, and reflection can lead to sustained change in values, attitudes, and behaviours.

  7. Extended HSR/CARD domain mediates AIRE binding to DNA.

    Science.gov (United States)

    Maslovskaja, Julia; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt

    2015-12-25

    Autoimmune regulator (AIRE) activates the transcription of many genes in an unusual promiscuous and stochastic manner. The mechanism by which AIRE binds to the chromatin and DNA is not fully understood, and the regulatory elements that AIRE target genes possess are not delineated. In the current study, we demonstrate that AIRE activates the expression of transiently transfected luciferase reporters that lack defined promoter regions, as well as intron and poly(A) signal sequences. Our protein-DNA interaction experiments with mutated AIRE reveal that the intact homogeneously staining region/caspase recruitment domain (HSR/CARD) and amino acids R113 and K114 are key elements involved in AIRE binding to DNA. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. SLEEP APNEA/HIPOPNEA SYNDROME (SAHS: HOME DIAGNOSIS AND TREATMENT

    Directory of Open Access Journals (Sweden)

    Coma del Corral MJ

    2006-02-01

    Full Text Available SUMMARYRecent studies associate SAHS with higher cardiovascular morbidity-mortality and we know that even today SAHS continues to be under-diagnosed. This under-diagnosis, signifies, on the one hand, a lowering or loss of health, and on the other, an increase in costs, since it has been demonstrated that patients with undiagnosed or untreated SAHS are higher consumers of health service resources and have higher work absenteeism, while these costs are reduced in SAHS patients treated with CPAP. Therefore, we find ourselves faced with the need to diagnose and suitably treat the largest possible number of patients who suffer from SAHS.The diagnostic method of choice continues to be supervised nocturnal PSG in the sleep laboratory, however, the future of SAHS diagnosis is inevitably moving towards the use of simplified systems with a high sensitivity and specificity. In this sense, the Respiratory Polygraphy represents an alternative tool for the diagnosis of SAHS, being able to be carried out in the home of the patient, just like the Auto-CPAP systems. Thus, the current approach to SAHS has changed and therefore, a patient with a high probability of suffering from SAHS, is able to have a RP carried out at home which might diagnose SAHS and later to have the CPAP adjusted to the optimum pressure level, as a recording using Auto-CPAP, could be carried out at home.With this new approach to SAHS, waiting lists could be reduced and thus reduce the under-diagnosis. All this brings about an implicit saving of resources. The place of diagnosis will basically be the home, and in this sense, the development of telematic applications will contribute significantly to the modification of diagnostic strategies.The success of this form of approach to SAHS, will be established with a suitable selection of subsidiary diagnosed patients and adjustment of home treatment, therefore, each sleep unit must set up its own diagnostic-therapeutic strategy which may be more

  9. Hypernatremia predicts adverse cardiovascular and neurological outcomes after SAH.

    Science.gov (United States)

    Fisher, Landis A; Ko, Nerissa; Miss, Jacob; Tung, Poyee P; Kopelnik, Alexander; Banki, Nader M; Gardner, David; Smith, Wade S; Lawton, Michael T; Zaroff, Jonathan G

    2006-01-01

    Abnormalities of serum sodium are common after subarachnoid hemorrhage (SAH) and have been linked to poor outcome. This study analyzed whether abnormal serum sodium levels are associated with cardiac outcomes and mortality after subarachnoid hemorrhage (SAH). In a prospective cohort study of SAH patients, the primary predictor variable was subjects' sodium level. Hypernatremia was defined as sodium >143 mmol/L and hyponatremia was study days. Dichotomous outcome variables were cTi > 1.0 microg/L, left-ventricular ejection fraction (LVEF) studied the degree of hypernatremia and sodium supplementation, and the temporal relationship between hypernatremia and cardiac outcomes. The study included 214 subjects. Forty-eight subjects (22%) were hypernatremic on at least one study day, and 45 (21%) were hyponatremic. After multivariate adjustment, hypernatremia was an independent predictor of LVEF hypernatremia is associated with adverse cardiac outcomes and death. SAH patients with hypernatremia should be monitored for evidence of cardiac dysfunction.

  10. An Extended DCT Domain Watermarking for Robot Vision against Geometric Image Attacks

    Directory of Open Access Journals (Sweden)

    Okkyung Choi

    2013-01-01

    Full Text Available With the rapid development of the Internet and the mobile service robot, the digital services are becoming important factors for robots to recognize things in the real world. Advances in computer technology and the risk of copyright infringement have increased in the way that anyone replicates and copies digital media easily. Therefore, ways to prevent and suppress copyright infringement, digital watermarking technologies that insert copyrights information into the work, are being researched. Digital watermark, depending on the actual insert domain, can be categorized into the spatial domain and transform domain. In this paper, we propose an extended DCT domain watermarking for robot vision. The suggested method is by distributing and duplicating watermark images that are including copyright information on the original images. By doing this, it can be strong on geometric image attacks such as partial cutting, resizing, rotating, and so forth. For the success of watermark extraction, invertible process can be used to recover a disfigured image. Experimental results are provided to support these methods, through the process of recombination by complete image pieces.

  11. Extended depth of focus adaptive optics spectral domain optical coherence tomography

    Science.gov (United States)

    Sasaki, Kazuhiro; Kurokawa, Kazuhiro; Makita, Shuichi; Yasuno, Yoshiaki

    2012-01-01

    We present an adaptive optics spectral domain optical coherence tomography (AO-SDOCT) with a long focal range by active phase modulation of the pupil. A long focal range is achieved by introducing AO-controlled third-order spherical aberration (SA). The property of SA and its effects on focal range are investigated in detail using the Huygens-Fresnel principle, beam profile measurement and OCT imaging of a phantom. The results indicate that the focal range is extended by applying SA, and the direction of extension can be controlled by the sign of applied SA. Finally, we demonstrated in vivo human retinal imaging by altering the applied SA. PMID:23082278

  12. SAH derived potent and selective EZH2 inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Kung, Pei-Pei; Huang, Buwen; Zehnder, Luke; Tatlock, John; Bingham, Patrick; Krivacic, Cody; Gajiwala, Ketan; Diehl, Wade; Yu, Xiu; Maegley, Karen A.

    2015-04-01

    A series of novel enhancer of zeste homolog 2 (EZH2) inhibitors was designed based on the chemical structure of the histone methyltransferase (HMT) inhibitor SAH (S-adenosyl-l-homocysteine). These nucleoside-based EZH2 inhibitors blocked the methylation of nucleosomes at H3K27 in biochemical assays employing both WT PRC2 complex as well as a Y641N mutant PRC2 complex. The most potent compound, 27, displayed IC50’s against both complexes of 270 nM and 70 nM, respectively. To our knowledge, compound 27 is the most potent SAH-derived inhibitor of the EZH2 PRC2 complex yet identified. This compound also displayed improved potency, lipophilic efficiency (LipE), and selectivity profile against other lysine methyltransferases compared with SAH.

  13. Optical Signatures of Quantum Delocalization over Extended Domains in Photosynthetic Membranes.

    Science.gov (United States)

    Schroeder, Christopher A; Caycedo-Soler, Felipe; Huelga, Susana F; Plenio, Martin B

    2015-08-27

    The prospect of coherent dynamics and excitonic delocalization across several light-harvesting structures in photosynthetic membranes is of considerable interest, but challenging to explore experimentally. Here we demonstrate theoretically that the excitonic delocalization across extended domains involving several light-harvesting complexes can lead to unambiguous signatures in the optical response, specifically, linear absorption spectra. We characterize, under experimentally established conditions of molecular assembly and protein-induced inhomogeneities, the optical absorption in these arrays from polarized and unpolarized excitation, and demonstrate that it can be used as a diagnostic tool to determine the resonance coupling between iso-energetic light-harvesting structures. The knowledge of these couplings would then provide further insight into the dynamical properties of transfer, such as facilitating the accurate determination of Förster rates.

  14. Emulsification of partially miscible liquids using colloidal particles: nonspherical and extended domain structures.

    Science.gov (United States)

    Clegg, Paul S; Herzig, Eva M; Schofield, Andrew B; Egelhaaf, Stefan U; Horozov, Tommy S; Binks, Bernard P; Cates, Michael E; Poon, Wilson C K

    2007-05-22

    We present microscopy studies of particle-stabilized emulsions with unconventional morphologies. The emulsions comprise pairs of partially miscible fluids and are stabilized by colloids. Alcohol-oil mixtures are employed; silica colloids are chemically modified so that they have partial wettability. We create our morphologies by two distinct routes: starting with a conventional colloid-stabilized emulsion or starting in the single-fluid phase with the colloids dispersed. In the first case temperature cycling leads to the creation of extended fluid domains built around some of the initial fluid droplets. In the second case quenching into the demixed region leads to the formation of domains which reflect the demixing kinetics. The structures are stable due to a jammed, semisolid, multilayer of colloids on the liquid-liquid interface. The differing morphologies reflect the roles in formation of the arrested state of heterogeneous and homogeneous nucleation and spinodal decomposition. The latter results in metastable, bicontinuous emulsions with frozen interfaces, at least for the thin-slab samples, investigated here.

  15. Extending pathways based on gene lists using InterPro domain signatures

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    Wiemann Stefan

    2008-01-01

    Full Text Available Abstract Background High-throughput technologies like functional screens and gene expression analysis produce extended lists of candidate genes. Gene-Set Enrichment Analysis is a commonly used and well established technique to test for the statistically significant over-representation of particular pathways. A shortcoming of this method is however, that most genes that are investigated in the experiments have very sparse functional or pathway annotation and therefore cannot be the target of such an analysis. The approach presented here aims to assign lists of genes with limited annotation to previously described functional gene collections or pathways. This works by comparing InterPro domain signatures of the candidate gene lists with domain signatures of gene sets derived from known classifications, e.g. KEGG pathways. Results In order to validate our approach, we designed a simulation study. Based on all pathways available in the KEGG database, we create test gene lists by randomly selecting pathway genes, removing these genes from the known pathways and adding variable amounts of noise in the form of genes not annotated to the pathway. We show that we can recover pathway memberships based on the simulated gene lists with high accuracy. We further demonstrate the applicability of our approach on a biological example. Conclusion Results based on simulation and data analysis show that domain based pathway enrichment analysis is a very sensitive method to test for enrichment of pathways in sparsely annotated lists of genes. An R based software package domainsignatures, to routinely perform this analysis on the results of high-throughput screening, is available via Bioconductor.

  16. Extended Gersgorin Theorem-Based Parameter Feasible Domain to Prevent Harmonic Resonance in Power Grid

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    Tao Lin

    2017-10-01

    Full Text Available Harmonic resonance may cause abnormal operation and even damage of power facilities, further threatening normal and safe operation of power systems. For renewable energy generations, controlled loads and parallel reactive power compensating equipment, their operating statuses can vary frequently. Therefore, the parameters of equivalent fundamental and harmonic admittance/impedance of these components exist in uncertainty, which will change the elements and eigenvalues of harmonic network admittance matrix. Consequently, harmonic resonance in power grid is becoming increasingly more complex. Hence, intense research about prevention and suppression of harmonic resonance, particularly the parameter feasible domain (PFD which can keep away from harmonic resonance, are needed. For rapid online evaluation of PFD, a novel method without time-consuming pointwise precise eigenvalue computations is proposed. By analyzing the singularity of harmonic network admittance matrix, the explicit sufficient condition that the matrix elements should meet to prevent harmonic resonance is derived by the extended Gersgorin theorem. Further, via the non-uniqueness of similar transformation matrix (STM, a strategy to determine the appropriate STM is proposed to minimize the conservation of the obtained PFD. Eventually, the availability and advantages in computation efficiency and conservation of the method, are demonstrated through four different scale benchmarks.

  17. Performance of selection hyper-heuristics on the extended HyFlex domains

    OpenAIRE

    Almutairi, Alhanof; Özcan, Ender; Kheiri, Ahmed; Jackson, Warren G.

    2016-01-01

    Selection hyper-heuristics perform search over the space of heuristics by mixing and controlling a predefined set of low level heuristics for solving computationally hard combinatorial optimisation problems. Being reusable methods, they are expected to be applicable to multiple problem domains, hence performing well in cross-domain search. HyFlex is a general purpose heuristic search API which separates the high level search control from the domain details enabling rapid development and perfo...

  18. Geophysical fingerprints of hyper-extended, exhumed and embryonic oceanic domains: the example from the Iberia-Newfoundland rifted margins

    Science.gov (United States)

    Stanton, Natasha; Manatschal, Gianreto; Autin, Julia; Sauter, Daniel; Maia, Marcia; Viana, Adriano

    2016-09-01

    This study investigates the magnetic and gravity signatures and associated seismic character of hyper-extended, exhumed and embryonic oceanic domains along the conjugate Iberia-Newfoundland rifted margins. As these margins have been drilled down to basement along their distal parts, it is possible to explore and test different geophysical techniques and interpretations. The aims of this work are twofold: (1) to investigate the location and nature of the two main marginal boundaries—the necking zone and the J Anomaly, which define the limits of major domains; and (2) to map the lateral variations of gravity and magnetic signatures and their detailed correlation with seismic data, from the proximal margin until the first unequivocal oceanic magnetic anomaly (e.g. C34 Anomaly). The results point out that the J Anomaly corresponds to a first-order tectono-magmatic boundary, with a basement formed by polyphase magmatism. It marks the boundary between the exhumed mantle domain, with little magmatic additions, from a domain oceanwards that reveals comparable trends, frequencies and a general magnetic pattern at both sides of the Atlantic, suggesting a coeval evolution. We propose that the domain between the J and the C34 Anomalies was formed by an embryonic spreading system, with intermittent budgets of magma, similar to those observed at very slow spreading systems. The J Anomaly may thus correspond to the location of lithospheric breakup though its origin and the nature of the domain oceanwards remains to be constrained.

  19. Modeling of VSC-Based Power Systems in The Extended Harmonic Domain

    DEFF Research Database (Denmark)

    Esparza, Miguel; Segundo-Ramirez, Juan; Kwon, Jun Bum

    2017-01-01

    Averaged modeling is a commonly used approach used to obtain mathematical representations of VSC-based systems. However, essential characteristics mainly related to the modulation process and the harmonic distortion of the signals are not able to be accurately captured and analyzed. The extended ...

  20. Aïté, bourg sahélien: aménagement et développement à dire d'acteurs

    Directory of Open Access Journals (Sweden)

    Yves CLOUET

    1995-09-01

    Full Text Available Comme on le constate à Aïté, gros bourg sahélien, les représentations mentales que tout habitant a de son territoire sont des outils d'analyse, de recherche et d'action originaux, efficaces et proches des chorèmes. Pourtant peu d'intervenants (agents techniques, administration, projets font l'effort de comprendre ce langage. Tout semble à inventer dans ce domaine.

  1. Extended coherence length Fourier domain mode locked lasers at 1310 nm.

    Science.gov (United States)

    Adler, Desmond C; Wieser, Wolfgang; Trepanier, Francois; Schmitt, Joseph M; Huber, Robert A

    2011-10-10

    Fourier domain mode locked (FDML) lasers are excellent tunable laser sources for frequency domain optical coherence tomography (FD-OCT) systems due to their combination of high sweep rates, large tuning ranges, and high output powers. However, conventional FDML lasers provide coherence lengths of only 4-10 mm, limiting their use in demanding applications such as intravascular OCT where coherence lengths of >20 mm are required for optimal imaging of large blood vessels. Furthermore, like most swept lasers, conventional FDML lasers produce only one useable sweep direction per tunable filter drive cycle, halving the effective sweep rate of the laser compared to the filter drive frequency. Here, we demonstrate a new class of FDML laser incorporating broadband dispersion compensation near 1310 nm. Elimination of chromatic dispersion in the FDML cavity results in the generation of forward (short to long wavelength) and backward (long to short wavelength) sweeps with substantially identical properties and coherence lengths of >21 mm. This advance enables long-range, high-speed FD-OCT imaging without the need for optical buffering stages, significantly reducing laser cost and complexity.

  2. Burden of disease and costs of aneurysmal subarachnoid haemorrhage (aSAH in the United Kingdom

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    Gray Alastair

    2010-04-01

    Full Text Available Abstract Background To estimate life years and quality-adjusted life years (QALYs lost and the economic burden of aneurysmal subarachnoid haemorrhage (aSAH in the United Kingdom including healthcare and non-healthcare costs from a societal perspective. Methods All UK residents in 2005 with aSAH (International Classification of Diseases 10th revision (ICD-10 code I60. Sex and age-specific abridged life tables were generated for a general population and aSAH cohorts. QALYs in each cohort were calculated adjusting the life tables with health-related quality of life (HRQL data. Healthcare costs included hospital expenditure, cerebrovascular rehabilitation, primary care and community health and social services. Non-healthcare costs included informal care and productivity losses arising from morbidity and premature death. Results A total of 80,356 life years and 74,807 quality-adjusted life years were estimated to be lost due to aSAH in the UK in 2005. aSAH costs the National Health Service (NHS £168.2 million annually with hospital inpatient admissions accounting for 59%, community health and social services for 18%, aSAH-related operations for 15% and cerebrovascular rehabilitation for 6% of the total NHS estimated costs. The average per patient cost for the NHS was estimated to be £23,294. The total economic burden (including informal care and using the human capital method to estimate production losses of a SAH in the United Kingdom was estimated to be £510 million annually. Conclusion The economic and disease burden of aSAH in the United Kingdom is reported in this study. Decision-makers can use these results to complement other information when informing prevention policies in this field and to relate health care expenditures to disease categories.

  3. Extending the Serum Half-Life of G-CSF via Fusion with the Domain III of Human Serum Albumin

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    Shuqiang Zhao

    2013-01-01

    Full Text Available Protein fusion technology is one of the most commonly used methods to extend the half-life of therapeutic proteins. In this study, in order to prolong the half-life of Granulocyte colony stimulating factor (G-CSF, the domain III of human serum albumin (3DHSA was genetically fused to the N-terminal of G-CSF. The 3DHSA-G-CSF fusion gene was cloned into pPICZαA along with the open reading frame of the α-factor signal under the control of the AOX1 promoter. The recombinant expression vector was transformed into Pichia pastoris GS115, and the recombinant strains were screened by SDS-PAGE. As expected, the 3DHSA-G-CSF showed high binding affinity with HSA antibody and G-CSF antibody, and the natural N-terminal of 3DHSA was detected by N-terminal sequencing. The bioactivity and pharmacokinetic studies of 3DHSA-G-CSF were respectively determined using neutropenia model mice and human G-CSF ELISA kit. The results demonstrated that 3DHSA-G-CSF has the ability to increase the peripheral white blood cell (WBC counts of neutropenia model mice, and the half-life of 3DHSA-G-CSF is longer than that of native G-CSF. In conclusion, 3DHSA can be used to extend the half-life of G-CSF.

  4. Transients analysis of the NPP-L V under conditions of extended power up rate using the extended operation domain; Analisis de transitorios de la CNLV en condiciones de aumento de potencia extendida empleando el dominio de operacion extendido

    Energy Technology Data Exchange (ETDEWEB)

    Lopez G, A.; Francois L, J. L. [UNAM, Facultad de Ingenieria, Ciudad Universitaria, 04510 Mexico D. F. (Mexico); Nunez C, A., E-mail: angelica.lopez.go24@gmail.com [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan No. 779, Col. Narvarte, 03020 Mexico D. F. (Mexico)

    2012-10-15

    The extended operation domain of the map flow-power allows operating to an extended power with a reduced flow in the core, this implies to expand the operation frontier to allow 120% of the original licensed thermal power (OLTP), with a flow in the core so low as 80% of the nominal flow, with a high pattern of control rods. The present work has as objective to study the response to recirculation operational transients of the nuclear power plant of Laguna Verde under conditions of Extended Power Up rate (EPU) and under the extended operation domain of the map flow-power. The content of this work covers the analysis of the thermal-hydraulic uncertainties obtained of the simulation of the recirculation pumps shot, as well as of the transition of high to low speed of these pumps. Both simulations were carried out for EPU conditions (120% of OLTP and 100% of flow in the core) and for the extended operation domain of the map flow-power, (120% of OLTP and 80% of flow in the core), this because the reactor will be situated in a region of high probability of uncertainty. At the present time any plant at world level has operated under EPU conditions under the extended operation domain of the map flow-power, for what the results of this work are innovative in this field, allowing to know the responses to the presented transients, and later on to develop the operative and regulatory conditions necessary for the operation of this domain, with the purpose of guaranteeing the safety. (Author)

  5. Aneurysmal subarachnoid haemorrhage (aSAH: Five consecutive years' experience of Fars province, Iran.

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    Abdolkarim Rahmanian

    Full Text Available Subarachnoid haemorrhage (SAH, caused by the rupture of intracranial aneurysms, is a devastating event with high rates of morbidity and mortality. Aneurysmal subarachnoid haemorrhage (aSAH plays a critical role in the potential loss of life as its sufferers are usually of a young age. We aimed to investigate the incidence of aSAH along with the patients' characteristics over five consecutive years in Fars, a large province located in Southern Iran.In this prospective study, anonymous data of all patients diagnosed with aSAH in Fars province were collected after patient admission and surgery. Data from the last national census in 2011 were used to calculate the incidence. The data were analysed using SPSS software version 18 using independent sample t test, chi square test and ANOVA. The significance level was set at 0.05.The number of aSAH cases identified in Fars, Iran, each year varied between 78 (2011 and 98 (2015 for a total of 421 aSAH cases within the 5-year study period. The annual aSAH incidence estimates showed no differences and were 1.65 [95% confidence interval (CI: 1.58-1.72], 1.70 (95%CI: 1.68-1.72, 1.71 (95%CI: 1.63-1.78, 1.82 (95%CI: 1.74-1.9, and 2.05 (95%CI: 1.97-2.13 per 100,000 persons, respectively, for the five consecutive years from 21 March 2011 to 20 March 2016. Hypertension was the most common risk factor, and was found in 198 (48% aSAH patients. Ninety-four (22.5% patients had moderate hydrocephalus on admission. Middle cerebral artery and anterior communicating artery were the most common sites of aneurysms. On admission, 351 (83% patients had a Glasgow Coma Scale score >7, 197 (47% presented with Hunt and Hess score of 1, and 365 (87% had a Fisher score of ≤3. Multiple aneurysms were found in 59 (14% of the 421 cases and the most common risk factors in multiple aneurysms were hypertension in 30 (51% and smoking in 26 (44% cases. Survival data were available only on patients diagnosed in year 2015, and the six

  6. Pushing the P300-based brain-computer interface beyond 100 bpm: extending performance guided constraints into the temporal domain.

    Science.gov (United States)

    Townsend, G; Platsko, V

    2016-04-01

    A new presentation paradigm for the P300-based brain-computer interface (BCI) referred to as the 'asynchronous paradigm' (ASP) is introduced and studied. It is based on the principle of performance guided constraints (Townsend et al 2012 Neurosci. Lett. 531 63-8) extended from the spatial domain into the temporal domain. The traditional constraint of flashing targets in predefined constant epochs of time is eliminated and targets flash asynchronously with timing based instead on constraints intended to improve performance. We propose appropriate temporal constraints to derive the ASP and compare its performance to that of the 'checkerboard paradigm' (CBP), which has previously been shown to be superior to the standard 'row/column paradigm' introduced by Farwell and Donchin (1988 Electroencephalogr. Clin. Neurophysiol. 70 510-23). Ten participants were tested in the ASP and CBP conditions both with traditional flashing items and with flashing faces in place of the targets (see Zhang et al 2012 J. Neural Eng. 9 026018; Kaufmann and Kübler 2014 J. Neural Eng. 11 ; Chen et al 2015 J. Neurosci. Methods 239 18-27). Eleven minutes of calibration data were used as input to a stepwise linear discriminant analysis to derive classification coefficients used for online classification. Accuracy was consistently high for both paradigms (87% and 93%) while information transfer rate was 45% higher for the ASP than the CBP. In a free spelling task, one subject spelled a 66 character sentence (from a 72 item matrix) with 100% accuracy in 3 min and 24 s demonstrating a practical throughput of 120 bits per minute (bpm) with a theoretical upper bound of 258 bpm. The subject repeated the task three times in a row without error. This work represents an advance in P300 speller technology and raises the ceiling that was being reached on P300-based BCIs. Most importantly, the research presented here is a novel and effective general strategy for organising timing for flashing items. The ASP

  7. Novel exenatide analogs with peptidic albumin binding domains: potent anti-diabetic agents with extended duration of action.

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    Odile E Levy

    Full Text Available The design, synthesis and pharmacology of novel long-acting exenatide analogs for the treatment of metabolic diseases are described. These molecules display enhanced pharmacokinetic profile and potent glucoregulatory and weight lowering actions compared to native exenatide. [Leu(14]exenatide-ABD is an 88 residue peptide amide incorporating an Albumin Binding Domain (ABD scaffold. [Leu(14]exenatide-ABP is a 53 residue peptide incorporating a short Albumin Binding Peptide (ABP. [Leu(14]exenatide-ABD and [Leu(14]exenatide-ABP exhibited nanomolar functional GLP-1 receptor potency and were metabolically stable in vitro in human plasma and in a pancreatic digestive enzyme mixture. Both molecules displayed picomolar and nanomolar binding association with albumin across multiple species and circulating half lives of 16 and 11 hours, respectively, post a single IV dose in rats. Unlike exenatide, both molecules elicited robust glucose lowering when injected 1 day prior to an oral glucose tolerance test, indicative of their extended duration of action. [Leu(14]exenatide-ABD was compared to exenatide in a Lep (ob/ob mouse model of diabetes. Twice-weekly subcutaneously dosed [Leu(14]exenatide-ABD displayed superior glucose lowering and weight loss in diabetic mice when compared to continuously infused exenatide at the same total weekly dose. A single oral administration of each molecule via an enteric coated capsule to cynomolgus monkeys showed superior pharmacokinetics for [Leu(14]exenatide-ABD as compared to [Leu(14]exenatide-ABP with detectable exposure longer than 14 days. These studies support the potential use of these novel long acting exenatide analogs with different routes of administration for the treatment of type 2 diabetes.

  8. Saxifraga cotyledon en l'Aigüeta de la Vall (Sahún, Huesca)

    OpenAIRE

    Ferrández Palacio, José Vicente

    2014-01-01

    Presentamos los datos recogidos en 2013 en la población de Saxifraga cotyledon relocalizada en el valle pirenaico de l'Aigüeta de la Ball (Ribagorza, Sahún). También se comentan algunos aspectos relativos a su conservación.

  9. ASPEK PEMIDANAAN HUKUM PERKAWINAN SIRRÎDALAM PERSPEKTIF SIYÂSAH SYAR’IYYAH

    Directory of Open Access Journals (Sweden)

    Khaeron Sirin

    2013-03-01

    Full Text Available Abstrak: Gagasan tentang pemidanaan terhadap kasus perkawinan yang tidak dicatatkan—biasa disebut perkawinan sirrî—yang mencuat di awal 2010 langsung memunculkan polemik. Bagi masyarakat yang mendukung, pemidanaan perkawinan yang tidak dicatatkan akan bisa memperketat prilaku perkawinan yang semena-mena, melindungi hak-hak perempuan dan anak-anak, serta menumbuhkan budaya tertib hukum di masyarakat. Sementara bagi kalangan yang menentang, perkawinan yang tidak dicatatkan adalah tetap sah secara agama (Islam—jika dilakukan sesuai syarat dan rukun nikahnya—dan negara tidak bisa memidanakan pelaku perkawinan yang tidak mencatatkan perkawinannyake instansi pemerintah.Tulisan ini berusaha mengana-lisis polemik tersebut dari sudut pandang siyâsah syar`iyyah, utamanya berkait dengan peluang dimasukkannya aspek hukum pidana dalam penerapan hukum perkawinan di Indonesia. Abstract: The notion of criminalizing on illegal (not legally registered marriage appearing in the early 2010 resulted polemics. Those who support this idea argue that it could tighten an unfair marriage, protect children and women rights, and create law-abiding culture concerning marriage in society. Those who deny the notion claim that an unregistered marriage is consider lawful from the perspective of Islam as long as it fulfils marriage principles and requirements. This article aims to analyze the case of unregistered marriage in Indonesia by siyâsah shar’iyyah perspective. Kata Kunci: Pemidanaan, perkawinansirrî, hukum Islam, siyâsah syar’iyyah

  10. Short consensus repeat domains extend the E-selectin structure in order to grab cells out of flow

    KAUST Repository

    Aleisa, Fajr A

    2017-01-08

    Selectins are key adhesion molecules responsible for initiating a multistep process that leads a cell out of the blood circulation and into a tissue or organ. They are composed of an N-terminal extracellular C-type lectin like domain, followed by an Endothelial Growth Factor like domain (EGF), a defined number of short consensus repeats SCR (also called “sushi” domains), a transmembrane domain and a C-terminal cytoplasmic tail. The adhesion of cells (expressing ligands) to the endothelium (expressing the selection i.e., E-selectin) occurs through the interaction between the lectin domain of selectins and sLeX presenting ligands. Structural/function studies to date have mainly focused on investigating the influence of the lectin domain of E-selectin on its ability to bind its ligands while other domains received less atention. We prepared a number of different recombinant E-selectin proteins with changes in the SCR units. Specifically we generated wild-type E-selectin proteins as monomeric or dimeric structures, mutant proteins with varied numbers of SCRs as well as proteins where strategic residues were mutated to change the conformation of the selectin. Using a novel real time immunoprecipitation surface plasmon resonance (SPR)-based in vitro binding study developed in our lab, the interaction of recombinant E-selectin proteins with immunoprecipitated endogenous ligands (i.e. CD44) captured on a CM-5 chip was assessed. These studies provided quantitative binding kinetics with on and off rates of selectin-ligand interactions and suggested that robust binding is dependent on the presence of the SCRs and oligomerization. These results provide significant implications on the functional mechanism of E-selectin binding to its ligands.

  11. MRI-detection rate and incidence of lumbar bleeding sources in 190 patients with non-aneurysmal SAH.

    Directory of Open Access Journals (Sweden)

    Sepide Kashefiolasl

    Full Text Available Up to 15% of all spontaneous subarachnoid hemorrhages (SAH have a non-aneurysmal SAH (NASAH. The evaluation of SAH patients with negative digital subtraction angiography (DSA is sometimes a diagnostic challenge. Our goal in this study was to reassess the yield of standard MR-imaging of the complete spinal axis to rule out spinal bleeding sources in patients with NASAH.We retrospectively analyzed the spinal MRI findings in 190 patients with spontaneous NASAH, containing perimesencephalic (PM and non-perimesencephalic (NPM SAH, diagnosed by computer tomography (CT and/or lumbar puncture (LP, and negative 2nd DSA.190 NASAH patients were included in the study, divided into PM-SAH (n = 87; 46% and NPM-SAH (n = 103; 54%. Overall, 23 (22% patients had a CT negative SAH, diagnosed by positive LP. MR-imaging of the spinal axis detected two patients with lumbar ependymoma (n = 2; 1,05%. Both patients complained of radicular sciatic pain. The detection rate raised up to 25%, if only patients with radicular sciatic pain received an MRI.Routine radiological investigation of the complete spinal axis in NASAH patients is expensive and can not be recommended for standard procedure. However, patients with clinical signs of low-back/sciatic pain should be worked up for a spinal pathology.

  12. Fast Construction of SAH BVHs on the Intel Many Integrated Core (MIC) Architecture.

    Science.gov (United States)

    Wald, I

    2012-01-01

    We investigate how to efficiently build bounding volume hierarchies (BVHs) with surface area heuristic (SAH) on the Intel Many Integrated Core (MIC) Architecture. To achieve maximum performance, we use four key concepts: progressive 10-bit quantization to reduce cache footprint with negligible loss in BVH quality; an AoSoA data layout that allows efficient streaming and SIMD processing; high-performance SIMD kernels for binning and partitioning; and a parallelization framework with several build-specific optimizations. The resulting system is more than an order of magnitude faster than today's high-end GPU builders for comparable BVHs; it is usually faster even than spatial median builders; it can build SAH BVHs almost as fast as existing GPUs and CPUs- and CPU-based approaches can build regular grids; and in aggregate "build+render" performance is significantly faster than the best published numbers for either of these systems, be it CPU or GPU, BVH, kd-tree, or grid.

  13. Acute Paraplegia After Aneurysmal SAH: A Case Report of a Rare Complication and Review of the Literature.

    Science.gov (United States)

    Chiang, Yi-Chun; Lee, Chung-Hsih; Chen, Wen-Hsien; Tsuei, Yuang-Seng

    2016-04-01

    Paraplegia after intracranial aneurysmal subarachnoid hemorrhage (SAH) is a rare condition, and its pathogenesis is still unclear. We present a case of a ruptured basilar dissecting aneurysm treated with the stent-assisted coiling procedure. Progressive weakness of the lower limbs developed within 5 days postoperatively. Spinal magnetic resonance image showed SAH accumulation in the lumbosacral area. Emergency lumbar drainage was performed, and the patient's symptoms improved dramatically. To the best of our knowledge, this is the first report to describe the successful treatment of paraplegia after intracranial aneurysmal SAH. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold.

    Science.gov (United States)

    Zacharchenko, Thomas; Barsukov, Igor; Rigden, Daniel J; Bennett, Daimark; Mayans, Olga

    2016-10-01

    Human protein phosphatase 1 nuclear targeting subunit (PNUTS) plays critical roles in DNA repair, cell growth and survival. The N-terminal domain of PNUTS mediates interactions with Tox4 and the phosphatase and tensin homolog PTEN, which are essential for the roles of this protein. To study this N-terminal domain, we have established its recombinant overproduction in E. coli utilizing NusA fusion. Upon removal of the tag, the remaining PNUTS sample is soluble and highly pure. We have characterized the domain using circular dichroism and nuclear magnetic resonance and analyzed its sequence using bioinformatics. All data agree in suggesting that the PNUTS N-terminal segment adopts a compact, globular fold rich in α-helical content, where the folded fraction is substantially larger than the previously annotated fold. We conclude that this domain adopts a single fold, likely being an extended form of the transcription factor S-II leucine/tryptophan conserved-motif. Thermal denaturation yielded a melting temperature of ~49.5 °C, confirming the stability of the fold. These findings pave the way for the molecular characterization of functional interactions mediated by the N-terminal region of PNUTS.

  15. Extended criteria and predictors in college admission: Exploring the structure of study success and investigating the validity of domain knowledge

    Directory of Open Access Journals (Sweden)

    OLGA KUNINA

    2007-06-01

    Full Text Available The utility of aptitude tests and intelligence measures in the prediction of the success in college is one of the empirically best supported results in ability research. However, the structure of the criterion “study success” has not been appropriately investigated so far. Moreover, it remains unclear which aspect of intelligence – fluid intelligence or crystallized intelligence – has the major impact on the prediction. In three studies we have investigated the dimensionality of the criterion achievements as well as the relative contributions of competing ability predictors. In the first study, the dimensionality of college grades was explored in a sample of 629 alumni. A measurement model with two correlated latent factors distinguishing undergraduate college grades on the one hand from graduate college grades on the other hand had the best fit to the data. In the second study, a group of 179 graduate students completed a Psychology knowledge test and provided available college grades in undergraduate studies. A model separating a general latent factor for Psychology knowledge from a nested method factor for college grades, and a second nested factor for “experimental orientation” had the best fit to the data. In the third study the predictive power of domain specific knowledge tests in Mathematics, English, and Biology was investigated. A sample of 387 undergraduate students in this prospective study additionally completed a compilation of fluid intelligence tests. The results of this study indicate as expected that: a ability measures are incrementally predictive over school grades in predicting exam grades; and b that knowledge tests from relevant domains were incrementally predictive over fluid intelligence. The results of these studies suggest that criteria for college admission tests deserve and warrant more attention, and that domain specific ability indicators can contribute to the predictive validity of established

  16. Anti-epileptic Drug (AED) Use in Subarachnoid Hemorrhage (SAH) and Intracranial Hemorrhage (ICH).

    Science.gov (United States)

    Feng, Rui; Mascitelli, Justin; Chartrain, Alexander G; Margetis, Konstantinos; Mocco, J

    2017-10-30

    Aneurysmal subarachnoid hemorrhage (aSAH) and spontaneous intracranial hemorrhage (ICH) are frequently associated with epileptic complications. The use of anti-epileptic drugs (AEDs) for seizure prophylaxis, however, is controversial. In patients with aSAH, nonconvulsive status epilepticus has been associated with poor outcome. Effect of other forms of less severe epileptiform activity on clinical outcome remains unclear. Evidence on efficacy of AEDs in reducing seizure incidence is also mixed. However, increasing number of studies suggest that AEDs may have significant adverse effects on outcome, especially with phenytoin. Similarly, in patients with ICH, the impact of seizures that do not progress to status epilepticus on clinical outcome is controversial, and whether prophylactic AED use has independent effects on outcome remains ambiguous. Currently, there are no large scale randomized control trials investigating the efficacy and safety of AED prophylaxis in patients with hemorrhagic stroke. There are also no trials comparing the efficacy and safety of the different AEDs. Survey based studies have found a wide range of prescribing patterns across treatment centers and clinicians for seizure prophylaxis in patients with hemorrhagic stroke. The lack of clear guidelines and recommendations also highlights the paucity of good quality evidence in this area. In conclusion, a well-designed randomized, double blinded, and appropriately powered trial is needed to evaluate the incidence as well as clinical outcomes in patients with aSAH and ICH who received AED prophylaxis versus controls. The results will be extremely valuable in providing evidence to establish management guidelines for patients with hemorrhagic stroke. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  17. Improving CPAP use by patients with the sleep apnoea/hypopnoea syndrome (SAHS).

    Science.gov (United States)

    Engleman, Heather M; Wild, Matt R

    2003-02-01

    Though continuous positive airway pressure (CPAP) is the treatment of choice for the sleep apnoea/hypopnoea syndrome (SAHS), suboptimal adherence to CPAP is common. Internationally, some 5-50% of SAHS patients recommended for CPAP either reject this treatment option or discontinue within the first week, and 12-25% of remaining patients can be expected to have discontinued CPAP by 3 years. Biomedical investigations of patients' CPAP use reveal frequent adverse effects, weak prospective relationships between symptomatic or physiological disease severity and CPAP use, and moderate correlations between use and benefit. Relatively expensive high-technological interventions to improve CPAP use (e.g. "intelligent" CPAP, humidification) are the subject of several well-conducted studies favouring their effectiveness. More basic educational and behavioural supports, and low-technological interventions (e.g. chinstraps, mask re-fitting) appear valued, but are currently less rigorously evaluated. In other diseases with demanding treatment regimens, cognitive constructs including health attitudes and beliefs (health value, locus of control, chance, powerful others, self-efficacy) and mental and physical health status are significant predictors of adherence. The enhancement of multidisciplinary models with psychosocial interpretations may provide increased explanatory and interventional potential in models of CPAP use. While acknowledging the scarcity of evidence, a structured, multidisciplinary, cost-efficient model is suggested, containing educational, behavioural and technological components as basic support, and with high-expertise cognitive-behavioural intervention in more difficult cases of low CPAP use.

  18. Assessment of cellular and plasma oxidative stress in SAHS patients before and after continuous positive airway pressure treatment.

    Science.gov (United States)

    Murri, M; Garcia-Delgado, R; Alcázar-Ramirez, J; Linde, F; Fernández-Ramos, A; Cardona, F; Tinahones, F J

    2010-01-01

    Several indirect techniques have been used for measuring oxidative stress in sleep apnoea-hypopnoea syndrome (SAHS) patients. The purpose of this study was to find out if both, cellular or plasma oxidative stress evaluations, are good estimators to assess oxidative stress in SAHS patients before and after one month's CPAP treatment. The study included 28 SAHS patients requiring CPAP treatment and 15 healthy control subjects. Plasma and serum oxidative stress biomarkers (lipid peroxidation, total antioxidant capacity, and the activities of glutathione peroxidase, glutathione reductase, glutathione s-transferase, catalase and superoxide dismutase) were measured using commercial kits. Cellular oxidative stress biomarkers (mitochondrial membrane potential, intracellular glutathione, superoxide anion, and hydrogen peroxide) were analysed by flow cytometry. The Wilcoxon test for paired samples was used to compare oxidative stress and clinical parameters in patients before and after treatment with CPAP. Relationships in oxidative stress markers between controls and patients were analyzed using the Mann-Whitney U test. The Spearman correlation coefficient was calculated to estimate the linear correlations between variables. Oxidative stress was notably decreased after CPAP. Before CPAP, SAHS severity positively correlated with hydrogen peroxide levels, while negative correlations were observed between SAHS severity and plasma TAC in patients. Also, plasma glutathione peroxidase activity negatively correlated with cellular superoxide anion, while plasma superoxide dismutase activity positively correlated with intracellular glutathione. After CPAP, plasma TAC and glutathione peroxidase activity negatively correlated with cellular hydrogen peroxide and superoxide anion. In conclusion, this study seems to confirm that plasma and cellular assessment reflect, in the same way, the oxidative stress status of the studied patients. Furthermore, plasma total antioxidant capacity as

  19. Serial measurement of regional cerebral blood flow in patients with SAH using 133Xe inhalation and emission computerized tomography

    DEFF Research Database (Denmark)

    Mickey, B; Vorstrup, S; Voldby, Bo

    1984-01-01

    defined regional flow decrease in the vascular territories of the anterior or middle cerebral arteries. Severe vasospasm was noted in three of these patients in whom arteriography was performed in the 2nd week post SAH. Diffuse bihemispheric CBF decreases were noted later in the course of delayed......A noninvasive three-dimensional method for measuring cerebral blood flow (CBF), xenon-133 inhalation and emission computerized tomography, was used to investigate the CBF changes accompanying delayed neurological deterioration following subarachnoid hemorrhage (SAH). A total of 67 measurements were...

  20. Rehabilitation outcome of patients with severe and prolonged disorders of consciousness after aneurysmal subarachnoid hemorrhage (aSAH).

    Science.gov (United States)

    Klein, Anke-Maria; Howell, Kaitlen; Straube, Andreas; Pfefferkorn, Thomas; Bender, Andreas

    2013-10-01

    Our objectives were to evaluate rehabilitation outcome of aSAH survivors with severe disorders of consciousness (DOC) and to examine potential predictors of long-term outcome. Severe DOC includes patients in a vegetative state (VS) and in a minimally conscious state (MCS). This is a retrospective single-center cohort study of consecutive aSAH patients with severe and prolonged DOC upon admission to neurorehabilitation. Clinical assessments started right after discharge from ICU, a median of 26 days after the aSAH. Two different outcome criteria were used, one addressing the functional aspect (assessed by the Functional Independence Measure [FIM]) the other one addressing the level of consciousness ("behavioral outcome", assessed by the Coma Remission Scale [CRS]). Improved outcome was defined by an increase in FIM scores of at least 22 points (minimal clinically important difference) or by reaching a full score of 24 points on the CRS. Separate least square linear regression models were calculated to examine potential predictors for functional and behavioral outcome. Out of 63 patients, 19.0% and 39.7% of the patients achieved an improved functional and behavioral outcome, respectively. Age and level of consciousness upon admission to neurorehabilitation were independent prognostic factors for both outcome definitions. Both groups reached the better outcome category after a median of 11 and 9 weeks, respectively. In an individual patient, the longest delay to achievement of improved functional outcome was 30 weeks and to favorable behavioral outcome was 22 weeks after rehabilitation admission. About one-third of severely affected aSAH patients with DOC regained at least a favorable behavioral status during early neurorehabilitation. It is interesting to note that in our study population, the beginning of clinical improvement took up to 6 months after aSAH. Copyright © 2013 Elsevier B.V. All rights reserved.

  1. Typologie spatiale de la végétation sahélienne en relation avec les ...

    African Journals Online (AJOL)

    hp

    RESUME. La variation spatiale du couvert végétal constitue un des déterminismes majeurs de la qualité des écosystèmes. Elle influence la physionomie spatiale de la végétation ainsi que les mutations des ressources naturelles. L'objectif de ce travail est d'examiner la typologie spatiale de la végétation sahélienne selon ...

  2. SAH-induced suppression of voltage-gated K+ (KV) channel currents in parenchymal arteriolar myocytes involves activation of the HB-EGF/EGFR pathway

    Science.gov (United States)

    Koide, Masayo; Wellman, George C.

    2013-01-01

    Summary Potassium channels play an important role in the regulation of arterial tone and decreased activity of these ion channels has been linked to pial artery vasospasm after subarachnoid hemorrhage (SAH). Our previous work has shown that acute application of a blood component, oxyhemoglobin, caused suppression of voltage-gated K+ (KV) channels through heparin-binding epidermal growth factor-like growth factor (HB-EGF) mediated activation of epidermal growth factor receptor (EGFR). Using patch clamp electrophysiology, we have now examined whether this pathway of KV channel suppression is activated in parenchymal arteriolar myocytes following long-term in vivo exposure to subarachnoid blood. We have found that KV currents, but not large conductance Ca2+ activated or inwardly rectifying K+ channel currents, were decreased in parenchymal arteriolar myocytes freshly isolated from Day-5 SAH model rabbits. Interestingly, parenchymal arteriolar myocytes from control animals were more sensitive to exogenous HB-EGF (IC50: 0.2 ± 0.4 ng/mL) compared to pial arterial myocytes (IC50: 2.4 ±1.3 ng/mL). However, HB-EGF and oxyhemoglobin failed to decrease KV currents in parenchymal arteriolar myocytes from SAH animals, consistent with EGFR activation and KV current suppression by SAH. These data suggest that HB-EGF/EGFR pathway activation contributes to KV current suppression and enhanced parenchymal arteriolar constriction after SAH. PMID:22890666

  3. SAH-induced suppression of voltage-gated K(+) (K (V)) channel currents in parenchymal arteriolar myocytes involves activation of the HB-EGF/EGFR pathway.

    Science.gov (United States)

    Koide, Masayo; Wellman, George C

    2013-01-01

    Potassium channels play an important role in the regulation of arterial tone, and decreased activity of these ion channels has been linked to pial artery vasospasm after subarachnoid hemorrhage (SAH). Our previous work has shown that acute application of a blood component, oxyhemoglobin, caused suppression of voltage-gated K(+) (K(V)) channels through heparin-binding epidermal growth factor-like growth factor (HB-EGF)-mediated activation of epidermal growth factor receptor (EGFR). Using patch clamp electrophysiology, we have now examined whether this pathway of K(V) channel suppression is activated in parenchymal arteriolar myocytes following long-term in vivo exposure to subarachnoid blood. We have found that K(V) currents, but not large conductance Ca(2+) activated or inwardly rectifying K(+) channel currents, were decreased in parenchymal arteriolar myocytes freshly isolated from day 5 SAH model rabbits. Interestingly, parenchymal arteriolar myocytes from control animals were more sensitive to exogenous HB-EGF (half-maximal inhibitory concentration [IC(50)] 0.2 ± 0.4 ng/ml) compared to pial arterial myocytes (IC(50) 2.4 ± 1.3 ng/ml). However, HB-EGF and oxyhemoglobin failed to decrease K(V) currents in parenchymal arteriolar myocytes from SAH animals, consistent with EGFR activation and K(V) current suppression by SAH. These data suggest that HB-EGF/EGFR pathway activation contributes to K(V) current suppression and enhanced parenchymal arteriolar constriction after SAH.

  4. ACTUACIÓN DOMICILIARIA EN EL SINDROME DE APNEAS/HIPOPNEAS DURANTE EL SUEÑO (SAHS: DIAGNÓSTICO Y TRATAMIENTO

    Directory of Open Access Journals (Sweden)

    Coma del Corral MJ

    2006-02-01

    Full Text Available RESUMEN:Estudios recientes, relacionan el SAHS con mayor morbimortalidad cardiovascular y por otro lado, sabemos que aún hoy en día, el SAHS sigue estando infradiagnosticado. Este infradiagnóstico supone, por un lado, un déficit o perdida de salud y por otro lado, un aumento de costes, ya que está demostrado que los pacientes con SAHS no diagnosticados ni tratados, son mayores consumidores de los servicios de salud y presentan mayor absentismo laboral, mientras que estos costes se reducen en los pacientes con SAHS tratados con CPAP. Por tanto, nos encontramos ante la necesidad de diagnosticar y tratar adecuadamente al mayor número posible de pacientes que padezcan un SAHS.El método diagnóstico de elección, sigue siendo la PSG nocturna vigilada en el laboratorio de sueño, sin embargo, el futuro del diagnóstico del SAHS pasa indefectiblemente por el empleo de sistemas simplificados con alta sensibilidad y especificidad. En este sentido, la Poligrafía Respiratoria, representa una alternativa útil para el diagnóstico del SAHS, pudiendo ser realizada en el domicilio del paciente, al igual que los sistemas Auto-CPAP. De esta forma, el abordaje actual del SAHS ha cambiado y así, un paciente con alta probabilidad de padecer un SAHS, se le puede realizar una PR domiciliaria que diagnostique el SAHS y posteriormente para ajustar el nivel de presión óptima de CPAP, se le podría hacer un registro domiciliario de Auto-CPAP.Con este nuevo abordaje del SAHS, se podrán disminuir las listas de espera y por tanto disminuir el infradiagnóstico. Todo ello conlleva implícitamente un ahorro de recursos. El lugar del diagnóstico, será fundamentalmente el domicilio, y en este sentido, el desarrollo de aplicaciones telemáticas contribuirá de forma importante a la modificación de las estrategias diagnósticas.El éxito de esta forma de abordaje del SAHS, vendrá marcado por una adecuada selección de los pacientes subsidiarios de diagnóstico y

  5. Soudure alimentaire et gestion sociétale des risques en zone sahélienne (Burkina Faso)

    OpenAIRE

    Janin, Pierre

    2003-01-01

    Depuis les graves crises alimentaires des années 1970 et 1980, les pays sahéliens, ont, tour à tour, exploré diverses stratégies pour gérer le risque d'insécurité alimentaire : planification de la redistribution de l'aide, stockage national de sécurité, prévisions pluviométriques, suivi satellitaire des cultures. Toutefois, ces approches ne dépassent généralement pas le cadre de la réponse immédiate à une situation d'urgence et ne permettent pas d'améliorer la gestion des disponibilités à l'é...

  6. Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year

    Science.gov (United States)

    Wong, George Kwok Chu; Lam, Sandy Wai; Ngai, Karine; Wong, Adrian; Siu, Deyond; Poon, Wai Sang; Mok, Vincent

    2013-01-01

    Background Cognitive domain deficits can occur after aneurysmal subarachnoid haemorrhage (aSAH) though few studies systemically evaluate its impact on 1-year outcomes. Objective We aimed to evaluate the pattern and functional outcome impact of cognitive domain deficits in aSAH patients at 1 year. Methods We carried out a prospective observational study in Hong Kong, during which, 168 aSAH patients (aged 21–75 years and had been admitted within 96 h of ictus) were recruited over a 26-month period. The cognitive function was assessed by a domain-specific neuropsychological assessment battery at 1 year after ictus. The current study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193). Results Prevalence of individual domain deficits varied between 7% to 15%, and 13% had two or more domain deficits. After adjusting for abbreviated National Institute of Health Stroke Scale and Geriatric Depressive Scale scores, unfavourable outcome (Modified Rankin Scale 3–5) and dependent instrumental activity of daily living (Lawton Instrumental Activity of Daily Living<15) were significantly associated with two or more domain deficits and number of cognitive domain deficits at 1 year. Two or more domain deficits was independently associated with age (OR, 1.1; 95% CI 1.1 to 1.2; p<0.001) and delayed cerebral infarction (OR, 6.1; 95% CI 1.1 to 33.5; p=0.036), after adjustment for years of school education. Interpretation In patients with aSAH, cognitive domain deficits worsened functional outcomes at 1 year. Delayed cerebral infarction was an independent risk factor for two or more domain deficits at 1 year. PMID:23606736

  7. Extended Paper: Reconceptualising Foundational Assumptions of Resilience: A Cross-Cultural, Spatial Systems Domain of Relevance for Agency and Phenomenology in Resilience

    Directory of Open Access Journals (Sweden)

    Paul Downes

    2017-04-01

    Full Text Available This article seeks to amplify Bronfenbrenner‘s (1979 concerns with concentric structured, nested systems and phenomenology, for Ungar‘s (2012 extension of resilience to systems based on Bronfenbrenner‘s (1979, 1995 socio-ecological paradigm. Resilience rests on interconnected assumptions regarding space, agency and system blockage, as well as the role of individual phenomenological dimensions. This article proposes a specific model of dynamic spatial systems of relation to underpin agency and phenomenology in resilience, building on a reinterpretation of Lévi-Strauss‘ (1962, 1963, 1973 cross-cultural observations of contrasts between concentric and diametric spatial systems; space is a key bridge between material, symbolic and interpersonal domains of relevance for resilience. Agency in resilience is interpreted in terms of movement between concentric and diametric spatial systems at social and school microsystem levels, as well as for individual phenomenology. Space is not just an object of analysis but an active constituent part of educational and developmental processes pertaining to resilience, as a malleable background contingent condition for causal trajectories. This framework of spatial-relational agency shifts focus for resilience from bouncing back into shape, towards transition points in space, moving from diametric spaces of splitting to concentric spatial relations of assumed connection across different system levels.

  8. Comparison of Montreal Cognitive Assessment and Mini-Mental State Examination in Evaluating Cognitive Domain Deficit Following Aneurysmal Subarachnoid Haemorrhage

    Science.gov (United States)

    Wong, George Kwok Chu; Lam, Sandy Wai; Wong, Adrian; Ngai, Karine; Poon, Wai Sang; Mok, Vincent

    2013-01-01

    Objective Cognitive deficits are common after aneurysmal subarachnoid haemorrhage (aSAH), and clinical evaluation is important for their management. Our hypothesis was that the Montreal Cognitive Assessment (MoCa) is superior to the Mini-Mental State Examination (MMSE) in screening for cognitive domain deficit in aSAH patients. Methods We carried out a prospective observational and diagnostic accuracy study on Hong Kong aSAH patients aged 21 to 75 years who had been admitted within 96 hours of ictus. The domain-specific neuropsychological assessment battery, the MoCA and MMSE were administered 2–4 weeks and 1 year after ictus. A cognitive domain deficit was defined as a cognitive domain z score ictus, the MoCA produced higher area under the curve scores for cognitive impairment than the MMSE (MoCA, 0.92; 95% CI, 0.83 to 0.97 versus MMSE, 0.77; 95% CI, 0.66 to 0.83, p = 0.009). Interpretation Cognitive domain deficits and cognitive impairment in patients with aSAH can be screened with the MoCA in both the subacute and chronic phases. PMID:23573223

  9. Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx).

    Science.gov (United States)

    Johnson, Ulf; Engquist, Henrik; Howells, Tim; Nilsson, Pelle; Ronne-Engström, Elisabeth; Lewén, Anders; Rostami, Elham; Enblad, Per

    2016-08-01

    Subarachnoid hemorrhage (SAH) is a disease with a high rate of unfavorable outcome, often related to delayed cerebral ischemia (DCI), i.e., ischemic injury that develops days-weeks after onset, with a multifactorial etiology. Disturbances in cerebral pressure autoregulation, the ability to maintain a steady cerebral blood flow (CBF), despite fluctuations in systemic blood pressure, have been suggested to play a role in the development of DCI. Pressure reactivity index (PRx) is a well-established measure of cerebral pressure autoregulation that has been used to study traumatic brain injury, but not extensively in SAH. To study the relation between PRx and CBF in SAH patients, and to examine if PRx can be used to predict DCI. Retrospective analysis of prospectively collected data. PRx was calculated as the correlation coefficient between mean arterial blood pressure (MABP) and intracranial pressure (ICP) in a 5 min moving window. CBF was measured using bedside Xenon-CT (Xe-CT). DCI was diagnosed clinically. 47 poor-grade mechanically ventilated patients were studied. Patients with disturbed pressure autoregulation (high PRx values) had lower CBF, as measured by bedside Xe-CT; both in the early (day 0-3) and late (day 4-14) acute phase of the disease. PRx did not differ significantly between patients who developed DCI or not. In mechanically ventilated and sedated SAH patients, high PRx (more disturbed CBF pressure autoregulation) is associated with low CBF, both day 0-3 and day 4-14 after onset. The role of PRx as a monitoring tool in SAH patients needs further studying.

  10. Extended Mixed Vector Equilibrium Problems

    Directory of Open Access Journals (Sweden)

    Mijanur Rahaman

    2014-01-01

    Full Text Available We study extended mixed vector equilibrium problems, namely, extended weak mixed vector equilibrium problem and extended strong mixed vector equilibrium problem in Hausdorff topological vector spaces. Using generalized KKM-Fan theorem (Ben-El-Mechaiekh et al.; 2005, some existence results for both problems are proved in noncompact domain.

  11. SAH-induced suppression of voltage-gated K+ (KV) channel currents in parenchymal arteriolar myocytes involves activation of the HB-EGF/EGFR pathway

    OpenAIRE

    Koide, Masayo; Wellman, George C.

    2013-01-01

    Potassium channels play an important role in the regulation of arterial tone and decreased activity of these ion channels has been linked to pial artery vasospasm after subarachnoid hemorrhage (SAH). Our previous work has shown that acute application of a blood component, oxyhemoglobin, caused suppression of voltage-gated K+ (KV) channels through heparin-binding epidermal growth factor-like growth factor (HB-EGF) mediated activation of epidermal growth factor receptor (EGFR). Using patch clam...

  12. Caractérisation de la végétation ligneuse sahélienne du Sénégal ...

    African Journals Online (AJOL)

    L'Analyse Factorielle des Correspondances a permis de discriminer trois groupements végétaux en étroite relation avec la localisation géographique et la géomorphologie des sites. Ainsi, dans le cadre d'une gestion durable et rationnelle des ressources naturelles en milieu sahélien, cette étude apporte des informations ...

  13. Non-invasive assessment of vasospasm following aneurysmal SAH using C-arm FDCT parenchymal blood volume measurement in the neuro-interventional suite: Technical feasibility

    Science.gov (United States)

    Downer, Jonathan; Corkill, Rufus; Byrne, James V

    2015-01-01

    Introduction Cerebral vasospasm is the leading cause of morbidity and mortality in patients with aneurysmal subarachnoid haemorrhage (SAH) surviving the initial ictus. Commonly used techniques for vasospasm assessment are digital subtraction angiography and transcranial Doppler sonography. These techniques can reliably identify only the major vessel spasm and fail to estimate its haemodynamic significance. To overcome these issues and to enable comprehensive non-invasive assessment of vasospasm inside the interventional suite, a novel protocol involving measurement of parenchymal blood volume (PBV) using C-arm flat detector computed tomography (FDCT) was implemented. Materials and methods Patients from the neuro-intensive treatment unit (ITU) with suspected vasospasm following aneurysmal SAH were scanned with a biplane C-arm angiography system using an intravenous contrast injection protocol. The PBV maps were generated using prototype software. Contemporaneous clinically indicated MR scan including the diffusion- and perfusion-weighted sequences was performed. C-arm PBV maps were compared against the MR perfusion maps. Results Distribution of haemodynamic impairment on C-arm PBV maps closely matched the pattern of abnormality on MR perfusion maps. On visual comparison between the two techniques, the extent of abnormality indicated PBV to be both cerebral blood flow and cerebral blood volume weighted. Conclusion C-arm FDCT PBV measurements allow an objective assessment of the severity and localisation of cerebral hypoperfusion resulting from vasospasm. The technique has proved feasible and useful in very sick patients after aneurysmal SAH. The promise shown in this early study indicates that it deserves further evaluation both for post-SAH vasospasm and in other relevant clinical settings. PMID:26017197

  14. Non-invasive assessment of vasospasm following aneurysmal SAH using C-arm FDCT parenchymal blood volume measurement in the neuro-interventional suite: Technical feasibility.

    Science.gov (United States)

    Kamran, Mudassar; Downer, Jonathan; Corkill, Rufus; Byrne, James V

    2015-08-01

    Cerebral vasospasm is the leading cause of morbidity and mortality in patients with aneurysmal subarachnoid haemorrhage (SAH) surviving the initial ictus. Commonly used techniques for vasospasm assessment are digital subtraction angiography and transcranial Doppler sonography. These techniques can reliably identify only the major vessel spasm and fail to estimate its haemodynamic significance. To overcome these issues and to enable comprehensive non-invasive assessment of vasospasm inside the interventional suite, a novel protocol involving measurement of parenchymal blood volume (PBV) using C-arm flat detector computed tomography (FDCT) was implemented. Patients from the neuro-intensive treatment unit (ITU) with suspected vasospasm following aneurysmal SAH were scanned with a biplane C-arm angiography system using an intravenous contrast injection protocol. The PBV maps were generated using prototype software. Contemporaneous clinically indicated MR scan including the diffusion- and perfusion-weighted sequences was performed. C-arm PBV maps were compared against the MR perfusion maps. Distribution of haemodynamic impairment on C-arm PBV maps closely matched the pattern of abnormality on MR perfusion maps. On visual comparison between the two techniques, the extent of abnormality indicated PBV to be both cerebral blood flow and cerebral blood volume weighted. C-arm FDCT PBV measurements allow an objective assessment of the severity and localisation of cerebral hypoperfusion resulting from vasospasm. The technique has proved feasible and useful in very sick patients after aneurysmal SAH. The promise shown in this early study indicates that it deserves further evaluation both for post-SAH vasospasm and in other relevant clinical settings. © The Author(s) 2015.

  15. Extended Emotions

    OpenAIRE

    Krueger, Joel; Szanto, Thomas

    2016-01-01

    Until recently, philosophers and psychologists conceived of emotions as brain- and body-bound affairs. But researchers have started to challenge this internalist and individualist orthodoxy. A rapidly growing body of work suggests that some emotions incorporate external resources and thus extend beyond the neurophysiological confines of organisms; some even argue that emotions can be socially extended and shared by multiple agents. Call this the extended emotions thesis (ExE). In this article...

  16. Rational extended thermodynamics

    CERN Document Server

    Müller, Ingo

    1998-01-01

    Ordinary thermodynamics provides reliable results when the thermodynamic fields are smooth, in the sense that there are no steep gradients and no rapid changes. In fluids and gases this is the domain of the equations of Navier-Stokes and Fourier. Extended thermodynamics becomes relevant for rapidly varying and strongly inhomogeneous processes. Thus the propagation of high­ frequency waves, and the shape of shock waves, and the regression of small-scale fluctuation are governed by extended thermodynamics. The field equations of ordinary thermodynamics are parabolic while extended thermodynamics is governed by hyperbolic systems. The main ingredients of extended thermodynamics are • field equations of balance type, • constitutive quantities depending on the present local state and • entropy as a concave function of the state variables. This set of assumptions leads to first order quasi-linear symmetric hyperbolic systems of field equations; it guarantees the well-posedness of initial value problems and f...

  17. Domains and domain loss

    DEFF Research Database (Denmark)

    Haberland, Hartmut

    2005-01-01

    The domain concept, originally suggested by Schmidt-Rohr in the 1930’s (as credited in Fishman’s writings in the 1970s), was an attempt to sort out different areas of language use in multilingual societies, which are relevant for language choice. In Fishman’s version, domains were considered...... as theoretical constructs that can explain language choice which were supposed to be a more powerful explanatory tool than more obvious (and observable) parameters like topic, place (setting) and interlocutor. In the meantime, at least in Scandinavia, the term ‘domain’ has been taken up in the debate among...... politicians and in the media, especially in the discussion whether some languages undergo ‘domain loss’ vis-à-vis powerful international languages like English. An objection that has been raised here is that domains, as originally conceived, are parameters of language choice and not properties of languages...

  18. Manejo del SAHS mediante dispositivos de avance mandibular: Estudio preliminar Sleep apnea-hypopnea syndrome management using a mandibular advancement device: Preliminary study

    Directory of Open Access Journals (Sweden)

    Manuel Sánchez-Moliní

    2010-12-01

    Full Text Available El tratamiento que ha demostrado mayor eficacia en los pacientes con síndrome de apneas-hipopneas del sueño (SAHS es la presión positiva continua de la vía aérea (CPAP. Los mayores inconvenientes son la incomodidad y la sensación de claustrofobia, que en algunos pacientes provoca rechazo o intolerancia. Una alternativa son los dispositivos de avance mandibular (DAM, que insertados en las arcadas dentarias producen el avance de la mandíbula y de la lengua, aumentando el volumen de la vía aérea. Objetivo: Presentar nuestra experiencia en el tratamiento del SAHS mediante dispositivos de avance mandibular tipo Herbst. Metodología: Estudio de seguimiento prospectivo desde junio de 2006 hasta enero de 2009 de 7 pacientes del Área Hospitalaria Virgen Macarena con SAHS que rechazan el tratamiento con CPAP y a los que se ofrece tratamiento con DAM. Las variables analizadas son: índice de apneas-hipopneas por hora, índice de desaturaciones por hora, intensidad subjetiva del ronquido y el test de somnolencia de Epworth, antes del tratamiento y al menos 6 meses después desde el inicio de su uso. Utilizamos el test de Wilcoxon para detectar diferencias estadísticas significativas (pThe most effective treatment in patients with sleep apnea-hypopnea syndrome (SAHS is CPAP (continuous positive airway pressure. The main drawback of CPAP is the discomfort and claustrophobic sensation that it causes, which elicits rejection or intolerance by some patients. A non-surgical alternative to CPAP is the mandibular advancement device (MAD, which consists of a plastic splint inserted between the dental arches to shift the jaw and tongue forward and thus increase airway volume. Objective: Report our experience with the treatment of SAHS using the Herbst mandibular advancement device. Material and method: A prospective follow-up study was carried out from June 2006 until January 2009 at the Virgen Macarena University Hospital with 7 patients with SAHS who

  19. Comparison of montreal cognitive assessment and mini-mental state examination in evaluating cognitive domain deficit following aneurysmal subarachnoid haemorrhage.

    Directory of Open Access Journals (Sweden)

    George Kwok Chu Wong

    Full Text Available Cognitive deficits are common after aneurysmal subarachnoid haemorrhage (aSAH, and clinical evaluation is important for their management. Our hypothesis was that the Montreal Cognitive Assessment (MoCa is superior to the Mini-Mental State Examination (MMSE in screening for cognitive domain deficit in aSAH patients.We carried out a prospective observational and diagnostic accuracy study on Hong Kong aSAH patients aged 21 to 75 years who had been admitted within 96 hours of ictus. The domain-specific neuropsychological assessment battery, the MoCA and MMSE were administered 2-4 weeks and 1 year after ictus. A cognitive domain deficit was defined as a cognitive domain z score <-1.65 (below the fifth percentile. Cognitive impairment was defined as two or more cognitive domain deficits. The study is registered at ClinicalTrials.gov of the US National Institutes of Health (NCT01038193.Both the MoCA and the MMSE were successful in differentiating between patients with and without cognitive domain deficits and cognitive impairment at both assessment periods. At 1 year post-ictus, the MoCA produced higher area under the curve scores for cognitive impairment than the MMSE (MoCA, 0.92; 95% CI, 0.83 to 0.97 versus MMSE, 0.77; 95% CI, 0.66 to 0.83, p = 0.009.Cognitive domain deficits and cognitive impairment in patients with aSAH can be screened with the MoCA in both the subacute and chronic phases.

  20. Occurrence of vasospasm and infarction in relation to a focal monitoring sensor in patients after SAH: placing a bet when placing a probe?

    Directory of Open Access Journals (Sweden)

    Christian T Ulrich

    Full Text Available INTRODUCTION: Vasospastic brain infarction is a devastating complication of aneurysmal subarachnoid hemorrhage (SAH. Using a probe for invasive monitoring of brain tissue oxygenation or blood flow is highly focal and may miss the site of cerebral vasospasm (CVS. Probe placement is based on the assumption that the spasm will occur either at the dependent vessel territory of the parent artery of the ruptured aneurysm or at the artery exposed to the focal thick blood clot. We investigated the likelihood of a focal monitoring sensor being placed in vasospasm or infarction territory on a hypothetical basis. METHODS: From our database we retrospectively selected consecutive SAH patients with angiographically proven (day 7-14 severe CVS (narrowing of vessel lumen >50%. Depending on the aneurysm location we applied a standard protocol of probe placement to detect the most probable site of severe CVS or infarction. We analyzed whether the placement was congruent with existing CVS/infarction. RESULTS: We analyzed 100 patients after SAH caused by aneurysms located in the following locations: MCA (n = 14, ICA (n = 30, A1CA (n = 4, AcoA or A2CA (n = 33, and VBA (n = 19. Sensor location corresponded with CVS territory in 93% of MCA, 87% of ICA, 76% of AcoA or A2CA, but only 50% of A1CA and 42% of VBA aneurysms. The focal probe was located inside the infarction territory in 95% of ICA, 89% of MCA, 78% of ACoA or A2CA, 50% of A1CA and 23% of VBA aneurysms. CONCLUSION: The probability that a single focal probe will be situated in the territory of severe CVS and infarction varies. It seems to be reasonably accurate for MCA and ICA aneurysms, but not for ACA or VBA aneurysms.

  1. Extended Emotions

    DEFF Research Database (Denmark)

    Krueger, Joel; Szanto, Thomas

    2016-01-01

    beyond the neurophysiological confines of organisms; some even argue that emotions can be socially extended and shared by multiple agents. Call this the extended emotions thesis (ExE). In this article, we consider different ways of understanding ExE in philosophy, psychology, and the cognitive sciences....... First, we outline the background of the debate and discuss different argumentative strategies for ExE. In particular, we distinguish ExE from cognate but more moderate claims about the embodied and situated nature of cognition and emotion (Section 1). We then dwell upon two dimensions of ExE: emotions......Until recently, philosophers and psychologists conceived of emotions as brain- and body-bound affairs. But researchers have started to challenge this internalist and individualist orthodoxy. A rapidly growing body of work suggests that some emotions incorporate external resources and thus extend...

  2. Extended thermodynamics

    CERN Document Server

    Müller, Ingo

    1993-01-01

    Physicists firmly believe that the differential equations of nature should be hyperbolic so as to exclude action at a distance; yet the equations of irreversible thermodynamics - those of Navier-Stokes and Fourier - are parabolic. This incompatibility between the expectation of physicists and the classical laws of thermodynamics has prompted the formulation of extended thermodynamics. After describing the motifs and early evolution of this new branch of irreversible thermodynamics, the authors apply the theory to mon-atomic gases, mixtures of gases, relativistic gases, and "gases" of phonons and photons. The discussion brings into perspective the various phenomena called second sound, such as heat propagation, propagation of shear stress and concentration, and the second sound in liquid helium. The formal mathematical structure of extended thermodynamics is exposed and the theory is shown to be fully compatible with the kinetic theory of gases. The study closes with the testing of extended thermodynamics thro...

  3. date extended

    Indian Academy of Sciences (India)

    C A L AN DER OF EVENTS. Date of issue of bid document : 2016 September 21. Extended Due date and Time for Receipt of Tender : Up to 2016 October 17, Time 13:00 Hrs. Date and Time of opening of bid : 2016 October 17, Time 15:00 Hrs. Cost of Bid Document : Rs. 100/- only (Non-refundable). Earnest Money Deposit ...

  4. Extending Puppet

    CERN Document Server

    Franceschi, Alessandro

    2014-01-01

    This book is a clear, detailed and practical guide to learn about designing and deploying you puppet architecture, with informative examples to highlight and explain concepts in a focused manner. This book is designed for users who already have good experience with Puppet, and will surprise experienced users with innovative topics that explore how to design, implement, adapt, and deploy a Puppet architecture. The key to extending Puppet is the development of types and providers, for which you must be familiar with Ruby.

  5. Domain analysis

    DEFF Research Database (Denmark)

    Hjørland, Birger

    2017-01-01

    The domain-analytic approach to knowledge organization (KO) (and to the broader field of library and information science, LIS) is outlined. The article reviews the discussions and proposals on the definition of domains, and provides an example of a domain-analytic study in the field of art studie....... Varieties of domain analysis as well as criticism and controversies are presented and discussed....

  6. Extending Experiences

    DEFF Research Database (Denmark)

    A computer game's player is experiencing not only the game as a designer-made artefact, but also a multitude of social and cultural practices and contexts of both computer game play and everyday life. As a truly multidisciplinary anthology, Extending Experiences sheds new light on the mesh...... of possibilities and influences the player engages with. Part one, Experiential Structures of Play, considers some of the key concepts commonly used to address the experience of a computer game player. The second part, Bordering Play, discusses conceptual and practical overlaps of games and everyday life...... and the impacts of setting up, crossing and breaking the boundaries of game and non-game. Part three, Interfaces of Play, looks at games as technological and historical artefacts and commodities. The fourth part, Beyond Design, introduces new models for the practical and theoretical dimensions of game design....

  7. Draft genome sequence of the extremely halophilic Halorubrum sp. SAH-A6 isolated from rock salts of the Danakil depression, Ethiopia

    Directory of Open Access Journals (Sweden)

    Ashagrie Gibtan

    2016-12-01

    Full Text Available The draft genome sequence of Halorubrum sp. SAH-A6, isolated from commercial rock salts of the Danakil depression, Ethiopia. The genome comprised 3,325,770 bp, with the G + C content of 68.0%. The strain has many genes which are responsible for secondary metabolites biosynthesis, transport and catabolism as compared to other Halorubrum archaea members. Abundant genes responsible for numerous transport systems, solute accumulation, and aromatic/sulfur decomposition were detected. The first genomic analysis encourages further research on comparative genomics, and biotechnological applications. The NCBI accession number for this genome is SAMN04278861 and ID: 4278861 and strain deposited with accession number KCTC 43215.

  8. Temporal profile of the effects of intracisternal injection of magnesium sulfate solution on vasodilation of spastic cerebral arteries in the canine SAH model.

    Science.gov (United States)

    Mori, Kentaro; Miyazaki, Masahiro; Hara, Yasukazu; Aiko, Yasuhisa; Yamamoto, Takuji; Nakao, Yasuaki; Esaki, Takanori

    2011-01-01

    the temporal profiles of the effects of intracisternal injection of magnesium sulfate (MgSO(4)) on vasodilation and cerebrospinal fluid (CSF) magnesium ion (Mg(2+)) concentration were investigated in the canine subarachnoid hemorrhage (SAH) model. cerebral vasospasm was induced using the two-hemorrhage model in seven female beagles. On day 7, 0.5 ml/kg of 15 mmol/l MgSO(4) in Ringer solution was injected into the cerebellomedullary cistern. Angiography was performed on day 1 (before SAH), and before and 1, 3, and 6 h after the intracisternal injection on day 7. CSF Mg(2+) was measured at the same time. the diameters of the basilar artery (BA), vertebral artery (VA), and superior cerebellar artery (SCA) before the intracisternal injection on day 7 were 0.59 ± 0.15, 0.41 ± 0.17, and 0.35 ± 0.17 mm, respectively, and were significantly decreased (p < 0.01) compared with the baseline diameters on day 1. The BA diameters at 1 h (0.74 ± 0.16 mm) and 3 h (0.73 ± 0.13 mm), the VA diameter at 1 h (0.64 ± 0.14 mm), and the SCA diameter at 3 h (0.54 ± 0.08 mm) after the injection were significantly increased (p < 0.05). The CSF Mg(2+) concentration was significantly increased (p < 0.01) at 1 h (3.59 ± 0.76 mEq/l) and 3 h (2.00 ± 0.31 mEq/l) after the injection compared with the baseline value (1.35 ± 0.23 mEq/l). the reversible effect of intracisternal MgSO(4) solution injection on the spastic artery depends on maintenance of the optimal CSF Mg(2+) concentration.

  9. Structural Studies of the SET Domain from RIZ1 Tumor Suppressor

    Energy Technology Data Exchange (ETDEWEB)

    Briknarova, Klara; Zhou, Xinliang; Satterthwait, Arnold C.; Hoyt, David W.; Ely, Kathryn R.; Huang, Shi

    2008-02-15

    Histone lysine methyltransferases (HKMTs) are involved in regulation of chromatin structure, and, as such, are important for longterm gene activation and repression that is associated with cell memory and establishment of cell-type specific transcriptional programs. Most HKMTs contain a SET domain, which is responsible for their catalytic activity. RIZ1 is a transcription regulator and tumor suppressor that catalyzes methylation of lysine 9 of histone H3 and contains a rather distinct SET domain. Similar SET domains, sometimes refererred to as PR (PRDI-BF1 and RIZ1 homology) domains, are also found in other proteins including Blimp-1/PRDI-BF1, MDS1-EVI1 and Meisetz. We determined the solution structure of the PR domain from RIZ1 and characterized its interaction with S-adenosyl homocysteine (SAH) and a peptide from histone H3. Despite low sequence identity with canonical SET domains, the PR domain displays a typical SET fold including a pseudo-knot at the C-terminus. The N-flanking sequence of RIZ1 PR domain adopts a novel conformation and interacts closely with the SET fold. The C-flanking sequence contains an α-helix that exhibits higher mobility than the SET fold and points away from the protein face that harbors active site in other SET domains. Residues that interact with the methylation cofactor in SET domains are not conserved in RIZ1 or other PR domains, and the SET fold of RIZ1 does not bind SAH. However, the PR domain of RIZ1 interacts specifically with a synthetic peptide comprising residues 1-20 of histone H3.

  10. Reasoning in incomplete domains

    Energy Technology Data Exchange (ETDEWEB)

    Rosenberg, S.

    1979-01-01

    Most real-world domains differ from the micro-worlds traditionally used in A.I. in that they have an incomplete factual data base which changes over time. Understanding in these domains can be thought of as the gneration of plausible infoerences which are able to use the facts available, and respond to changes in them. A traditional rule interpreter such as Planner can be extended to construct plausible inferences in these domains by allowing assumptions to be made in applying rules, resultsing in simplifications of rules which can be used in an incomplete data base; monitoring the antecedents and consequents of a rule so that inferences can be maintained over a changing data base.

  11. Impact des aménagements de conservation des eaux et des sols sur la régénération des ressources ligneuses en zone sahélienne et nord soudanienne du Burkina Faso

    OpenAIRE

    Ganaba, Souleymane

    2005-01-01

    La présente étude a pour but de suivre l’impact de techniques d’aménagement de conservation des eaux et des sols sur la composition spécifique, la structure et la régénération de la végétation ligneuse en zone sahélienne et nord-soudanienne. Elle a concerné six unités agropastorales (U.A.P) d’intervention d’un projet de développement dont 2 situées en zone nord-soudanienne  Boundoré et Kabo-Gountouré et 4 en zone sahélienne Dori Nord, Falagountou, Koréa et Sampelga. Elle a consisté en un inve...

  12. Geometry of Homogeneous Bounded Domains

    CERN Document Server

    Vesentini, E

    2011-01-01

    This title includes: S.G. Gindikin, I.I. Pjateckii-Sapiro, E.B. Vinberg: Homogeneous Kahler manifolds; S.G. Greenfield: Extendibility properties of real submanifolds of Cn; W. Kaup: Holomorphische Abbildungen in Hyperbolische Raume; A. Koranyi: Holomorphic and harmonic functions on bounded symmetric domains; J.L. Koszul: Formes harmoniques vectorielles sur les espaces localement symetriques; S. Murakami: Plongements holomorphes de domaines symetriques; and E.M. Stein: The analogues of Fatous' theorem and estimates for maximal functions.

  13. Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage.

    Science.gov (United States)

    Ding, Ya-Suo; Sun, Bing; Jiang, Jian-Xin; Zhang, Qin; Lu, Jun; Gao, Guang-Zhong

    2016-08-01

    Signal peptide-Cub-Epidermal growth factor domain-containing protein 1 (SCUBE1), a marker for coagulation, is correlated with prognosis of some critical illnesses. The current study was designed to investigate the potential prognostic value of serum SCUBE1 concentrations in patients with aneurysmal subarachnoid hemorrhage (aSAH). Serum SCUBE1 concentrations of 125 patients and 125 controls were determined. Multivariate analyses were performed to identify independent risk factors for 6-month mortality, overall survival and unfavorable outcome (Glasgow Outcome Scale score of 1-3). Serum SCUBE1 concentrations were significantly higher in patients than in controls (17.7±7. vs. 1.2±0.4ng/ml, P<0.001) and were associated highly with World Federation of Neurological Surgeons (WFNS) scores (t=5.109, P<0.001) and modified Fisher scores (t=4.329, P<0.001). SCUBE1 emerged as an independent predictor for 6-month clinical outcomes. It had similar area under receiver operating characteristic curve (AUC) to WFNS scores and modified Fisher scores. Moreover, it could markedly improve the AUC of WFNS scores and modified Fisher scores to predict 6-month unfavorable outcome. Enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aSAH patients, indicating SCUBE1 might have the potential to identify aSAH patients at risk of poor prognosis. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. Domain crossing

    DEFF Research Database (Denmark)

    Schraefel, M. C.; Rouncefield, Mark; Kellogg, Wendy

    2012-01-01

    In CSCW, how much do we need to know about another domain/culture before we observe, intersect and intervene with designs. What optimally would that other culture need to know about us? Is this a “how long is a piece of string” question, or an inquiry where we can consider a variety of contexts...

  15. Silicone chain extender

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a silicone chain extender, more particularly a chain extender for silicone polymers and copolymers, to a chain extended silicone polymer or copolymer and to a functionalized chain extended silicone polymer or copolymer, to a method for the preparation thereof...

  16. Trusted Domain

    DEFF Research Database (Denmark)

    Hjorth, Theis Solberg; Torbensen, Rune

    2012-01-01

    In the digital age of home automation and with the proliferation of mobile Internet access, the intelligent home and its devices should be accessible at any time from anywhere. There are many challenges such as security, privacy, ease of configuration, incompatible legacy devices, a wealth...... of wireless standards, limited resources of embedded systems, etc. Taking these challenges into account, we present a Trusted Domain home automation platform, which dynamically and securely connects heterogeneous networks of Short-Range Wireless devices via simple non-expert user. interactions, and allows...... remote access via IP-based devices such as smartphones. The Trusted Domain platform fits existing legacy technologies by managing their interoperability and access controls, and it seeks to avoid the security issues of relying on third-party servers outside the home. It is a distributed system...

  17. Towards a continuous modeling of natural language domains

    OpenAIRE

    Ruder, Sebastian; Ghaffari, Parsa; Breslin, John G.

    2016-01-01

    Humans continuously adapt their style and language to a variety of domains. However, a reliable definition of `domain' has eluded researchers thus far. Additionally, the notion of discrete domains stands in contrast to the multiplicity of heterogeneous domains that humans navigate, many of which overlap. In order to better understand the change and variation of human language, we draw on research in domain adaptation and extend the notion of discrete domains to the continuous spectrum. We pro...

  18. Beyond cross-domain learning: Multiple-domain nonnegative matrix factorization

    KAUST Repository

    Wang, Jim Jing-Yan

    2014-02-01

    Traditional cross-domain learning methods transfer learning from a source domain to a target domain. In this paper, we propose the multiple-domain learning problem for several equally treated domains. The multiple-domain learning problem assumes that samples from different domains have different distributions, but share the same feature and class label spaces. Each domain could be a target domain, while also be a source domain for other domains. A novel multiple-domain representation method is proposed for the multiple-domain learning problem. This method is based on nonnegative matrix factorization (NMF), and tries to learn a basis matrix and coding vectors for samples, so that the domain distribution mismatch among different domains will be reduced under an extended variation of the maximum mean discrepancy (MMD) criterion. The novel algorithm - multiple-domain NMF (MDNMF) - was evaluated on two challenging multiple-domain learning problems - multiple user spam email detection and multiple-domain glioma diagnosis. The effectiveness of the proposed algorithm is experimentally verified. © 2013 Elsevier Ltd. All rights reserved.

  19. Diagnostic Value of 64-slice CTA in Detection of Intracranial Aneurysm in Patients with SAH and Comparison of the CTA Results with 2D-DSA and Intraoperative Findings

    Directory of Open Access Journals (Sweden)

    Elif Ergun

    2011-03-01

    Full Text Available Objective: To prospectively evaluate the diagnostic value of 64-slice CTA in detecting intracranial aneurysms and to compare it with 2D-DSA and/or intra-operative findings.Material and Methods: 37 cases with SAH according to unenhanced cranial CT were included in the study. A 64-slice CTA was performed to all cases immediately after the nonenhanced cranial CT. DSA was performed in 24-48 hours following CTA. CT images were reviewed by two radiologists experienced in CT vascular imaging. The DSA reader was the angiographer who performed the DSA. The results of the CTA were compared with the DSA results and/or intraoperative findings in order to determine the diagnostic efficacy of CTA in detecting intracranial aneurysms. Results: Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CTA in detecting aneurysms were 92.8%, 83.3%, 96.2%, 71.4% and 91.2% respectively. The diagnostic value of CTA in detecting intracranial aneurysms was found to be equal to DSA by Mcnemar test. Conclusion: CTA is invaluable in detecting intracranial aneurysms. It may be used as a first line modality in SAH, and DSA may be reserved for patients with negative or equivocal CTA results.

  20. Extended icosahedral structures

    CERN Document Server

    Jaric, Marko V

    1989-01-01

    Extended Icosahedral Structures discusses the concepts about crystal structures with extended icosahedral symmetry. This book is organized into six chapters that focus on actual modeling of extended icosahedral crystal structures. This text first presents a tiling approach to the modeling of icosahedral quasiperiodic crystals. It then describes the models for icosahedral alloys based on random connections between icosahedral units, with particular emphasis on diffraction properties. Other chapters examine the glassy structures with only icosahedral orientational order and the extent of tra

  1. .Gov Domains API

    Data.gov (United States)

    General Services Administration — This dataset offers the list of all .gov domains, including state, local, and tribal .gov domains. It does not include .mil domains, or other federal domains outside...

  2. Extended family medicine training

    Science.gov (United States)

    Slade, Steve; Ross, Shelley; Lawrence, Kathrine; Archibald, Douglas; Mackay, Maria Palacios; Oandasan, Ivy F.

    2016-01-01

    Abstract Objective To examine trends in family medicine training at a time when substantial pedagogic change is under way, focusing on factors that relate to extended family medicine training. Design Aggregate-level secondary data analysis based on the Canadian Post-MD Education Registry. Setting Canada. Participants All Canadian citizens and permanent residents who were registered in postgraduate family medicine training programs within Canadian faculties of medicine from 1995 to 2013. Main outcome measures Number and proportion of family medicine residents exiting 2-year and extended (third-year and above) family medicine training programs, as well as the types and numbers of extended training programs offered in 2015. Results The proportion of family medicine trainees pursuing extended training almost doubled during the study period, going from 10.9% in 1995 to 21.1% in 2013. Men and Canadian medical graduates were more likely to take extended family medicine training. Among the 5 most recent family medicine exit cohorts (from 2009 to 2013), 25.9% of men completed extended training programs compared with 18.3% of women, and 23.1% of Canadian medical graduates completed extended training compared with 13.6% of international medical graduates. Family medicine programs vary substantially with respect to the proportion of their trainees who undertake extended training, ranging from a low of 12.3% to a high of 35.1% among trainees exiting from 2011 to 2013. Conclusion New initiatives, such as the Triple C Competency-based Curriculum, CanMEDS–Family Medicine, and Certificates of Added Competence, have emerged as part of family medicine education and credentialing. In acknowledgment of the potential effect of these initiatives, it is important that future research examine how pedagogic change and, in particular, extended training shapes the care family physicians offer their patients. As part of that research it will be important to measure the breadth and uptake of

  3. Perspectivas actuales en el tratamiento del Síndrome de Apneas-Hipopneas del Sueño (SAHS) y dificultades para su implementación en nuestro medio.

    OpenAIRE

    Jorge Rey De Castro Mujica

    2013-01-01

    El Síndrome de Apneas-Hipopneas del Sueño (SAHS) es un trastorno serio de curso crónico caracterizado por episodios repetidos de colapso parcial o total de la vía aérea superior presentados durante el dormir. La interrupción y fraccionamiento del sueño produce excesiva somnolencia diurna (ESD). La información relacionada a su prevalencia indica que este desorden es común y puede fluctuar entre 2-4 % de los adultos en la edad media de la vida (1-3). Debido a su asociación con alteraciones neur...

  4. Extended defects in Germanium

    CERN Document Server

    Osgood, R M

    2008-01-01

    Intends to provide a fundamental understanding of the extended-defect formation during Ge materials and device processing, providing ways to distinguish harmful from less detrimental defects and should point out ways for defect engineering and control.

  5. Domain adaptation via transfer component analysis.

    Science.gov (United States)

    Pan, Sinno Jialin; Tsang, Ivor W; Kwok, James T; Yang, Qiang

    2011-02-01

    Domain adaptation allows knowledge from a source domain to be transferred to a different but related target domain. Intuitively, discovering a good feature representation across domains is crucial. In this paper, we first propose to find such a representation through a new learning method, transfer component analysis (TCA), for domain adaptation. TCA tries to learn some transfer components across domains in a reproducing kernel Hilbert space using maximum mean miscrepancy. In the subspace spanned by these transfer components, data properties are preserved and data distributions in different domains are close to each other. As a result, with the new representations in this subspace, we can apply standard machine learning methods to train classifiers or regression models in the source domain for use in the target domain. Furthermore, in order to uncover the knowledge hidden in the relations between the data labels from the source and target domains, we extend TCA in a semisupervised learning setting, which encodes label information into transfer components learning. We call this extension semisupervised TCA. The main contribution of our work is that we propose a novel dimensionality reduction framework for reducing the distance between domains in a latent space for domain adaptation. We propose both unsupervised and semisupervised feature extraction approaches, which can dramatically reduce the distance between domain distributions by projecting data onto the learned transfer components. Finally, our approach can handle large datasets and naturally lead to out-of-sample generalization. The effectiveness and efficiency of our approach are verified by experiments on five toy datasets and two real-world applications: cross-domain indoor WiFi localization and cross-domain text classification.

  6. An extended day program

    Directory of Open Access Journals (Sweden)

    Ševkušić-Mandić Slavica G.

    2002-01-01

    Full Text Available The paper presents the results of a pilot project evaluation, carried out as an action investigation whose aim was to provide a better quality extended day for primary school students. The project included the training of teachers involved in extended day program, designing of special activities performed by teachers with children once a week as well as changes and equipping of premises where children stay. The aims of the program were conception and performance of activities in a less formal way than during regular instructional days, linking of learning at school and acquired knowledge to everyday experiences, and work on contents contributing to the development of child's interests and creativity. The program was accomplished in a Belgrade primary school during the 2001/2002 academic year, comprising students of 1st and 2nd grades (N=77. The effects of the program were monitored throughout the academic year (observation and teachers' reports on accomplished workshops and at the end of the academic year (teachers and students' opinions of the program, academic achievement and creativity of students attending the extended day program compared with students not attending it. Findings about positive effects of the program on students' broadening of interests and willingness to express themselves creatively, indicate unequivocally that there is a need for developing special extended day programs. The extended day program is an opportunity for school to exert greater educational influence that has yet to be tapped.

  7. Extended spider cognition.

    Science.gov (United States)

    Japyassú, Hilton F; Laland, Kevin N

    2017-05-01

    There is a tension between the conception of cognition as a central nervous system (CNS) process and a view of cognition as extending towards the body or the contiguous environment. The centralised conception requires large or complex nervous systems to cope with complex environments. Conversely, the extended conception involves the outsourcing of information processing to the body or environment, thus making fewer demands on the processing power of the CNS. The evolution of extended cognition should be particularly favoured among small, generalist predators such as spiders, and here, we review the literature to evaluate the fit of empirical data with these contrasting models of cognition. Spiders do not seem to be cognitively limited, displaying a large diversity of learning processes, from habituation to contextual learning, including a sense of numerosity. To tease apart the central from the extended cognition, we apply the mutual manipulability criterion, testing the existence of reciprocal causal links between the putative elements of the system. We conclude that the web threads and configurations are integral parts of the cognitive systems. The extension of cognition to the web helps to explain some puzzling features of spider behaviour and seems to promote evolvability within the group, enhancing innovation through cognitive connectivity to variable habitat features. Graded changes in relative brain size could also be explained by outsourcing information processing to environmental features. More generally, niche-constructed structures emerge as prime candidates for extending animal cognition, generating the selective pressures that help to shape the evolving cognitive system.

  8. Extending quantum mechanics entails extending special relativity

    Science.gov (United States)

    Aravinda, S.; Srikanth, R.

    2016-05-01

    The complementarity between signaling and randomness in any communicated resource that can simulate singlet statistics is generalized by relaxing the assumption of free will in the choice of measurement settings. We show how to construct an ontological extension for quantum mechanics (QMs) through the oblivious embedding of a sound simulation protocol in a Newtonian spacetime. Minkowski or other intermediate spacetimes are ruled out as the locus of the embedding by virtue of hidden influence inequalities. The complementarity transferred from a simulation to the extension unifies a number of results about quantum non-locality, and implies that special relativity has a different significance for the ontological model and for the operational theory it reproduces. Only the latter, being experimentally accessible, is required to be Lorentz covariant. There may be certain Lorentz non-covariant elements at the ontological level, but they will be inaccessible at the operational level in a valid extension. Certain arguments against the extendability of QM, due to Conway and Kochen (2009) and Colbeck and Renner (2012), are attributed to their assumption that the spacetime at the ontological level has Minkowski causal structure.

  9. Quantum stochastic calculus with maximal operator domains

    OpenAIRE

    Lindsay, J. Martin; Attal, Stéphane

    2004-01-01

    Quantum stochastic calculus is extended in a new formulation in which its stochastic integrals achieve their natural and maximal domains. Operator adaptedness, conditional expectations and stochastic integrals are all defined simply in terms of the orthogonal projections of the time filtration of Fock space, together with sections of the adapted gradient operator. Free from exponential vector domains, our stochastic integrals may be satisfactorily composed yielding quantum Itô formulas for op...

  10. Domains in multiband superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Y., E-mail: y.tanaka@aist.go.jp [National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba-shi, Ibaraki-ken 305-8568 (Japan); Yanagisawa, T. [National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba-shi, Ibaraki-ken 305-8568 (Japan); Crisan, A. [University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)] [National Institute of Materials Physics, P.O. Box MG-7, Bucharest 077125 (Romania); Shirage, P.M.; Iyo, A. [National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba-shi, Ibaraki-ken 305-8568 (Japan); Tokiwa, K. [Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba-ken 278-8510 (Japan); Nishio, T. [Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601 (Japan); Sundaresan, A. [Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560 064 (India); Terada, N. [Kagoshima University, Korimoto 1-21-24, Kagoshima-shi, Kagoshima-ken 890-8580 (Japan)

    2011-11-15

    Positive interband Josephson interactions disperse order parameters. It creates configuration domain in multiband superconductors. This domain poses a problem for the stability of superconductivity. However it also offer new potential for novel electronics. Multiband superconductors can have several types of domains that are inhibited in conventional single-band superconductors. These domains are phase domains and chiral domains and their domain wall are an interband phase difference soliton. In a superconductor with an odd number of electronic bands (five or more) and with positive interband Josephson interactions, we find other types of domains with different interband phase differences. We call these domains configuration domains because pseudo-order parameters for each band are dispersed in the complex plain and several configurations, which have several local minima. Fractional vortices serve as hubs for phase difference solitons (configuration domain walls). The divergence of the number of configurations with local minima would pose a serious problem for the stability of superconductivity.

  11. Poster Session- Extended Abstracts

    Science.gov (United States)

    Jack D. Alexander III; Jean Findley; Brenda K. Kury; Jan L. Beyers; Douglas S. Cram; Terrell T. Baker; Jon C. Boren; Carl Edminster; Sue A. Ferguson; Steven McKay; David Nagel; Trent Piepho; Miriam Rorig; Casey Anderson; Jeanne Hoadley; Paulette L. Ford; Mark C. Andersen; Ed L. Fredrickson; Joe Truett; Gary W. Roemer; Brenda K. Kury; Jennifer Vollmer; Christine L. May; Danny C. Lee; James P. Menakis; Robert E. Keane; Zhi-Liang Zhu; Carol Miller; Brett Davis; Katharine Gray; Ken Mix; William P. Kuvlesky Jr.; D. Lynn Drawe; Marcia G. Narog; Roger D. Ottmar; Robert E. Vihnanek; Clinton S. Wright; Timothy E. Paysen; Burton K. Pendleton; Rosemary L. Pendleton; Carleton S. White; John Rogan; Doug Stow; Janet Franklin; Jennifer Miller; Lisa Levien; Chris Fischer; Emma Underwood; Robert Klinger; Peggy Moore; Clinton S. Wright

    2008-01-01

    Titles found within Poster Session-Extended Abstracts include:Assessment of emergency fire rehabilitation of four fires from the 2000 fire season on the Vale, Oregon, BLM district: review of the density sampling materials and methods: p. 329 Growth of regreen, seeded for erosion control, in the...

  12. Extending Critical Performativity

    DEFF Research Database (Denmark)

    Spicer, André; Alvesson, Mats; Kärreman, Dan

    2016-01-01

    In this article we extend the debate about critical performativity. We begin by outlining the basic tenets of critical performativity and how this has been applied in the study of management and organization. We then address recent critiques of critical performance. We note these arguments suffer...

  13. Parameterization of extended systems

    DEFF Research Database (Denmark)

    Niemann, Hans Henrik

    2006-01-01

    The YJBK parameterization (of all stabilizing controllers) is extended to handle systems with additional sensors and/or actuators. It is shown that the closed loop transfer function is still an affine function in the YJBK parameters in the nominal case. Further, some closed-loop stability results...

  14. Time Domain Stability Margin Assessment Method

    Science.gov (United States)

    Clements, Keith

    2017-01-01

    The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

  15. Extended Irreversible Thermodynamics

    CERN Document Server

    Jou, David

    2010-01-01

    This is the 4th edition of the highly acclaimed monograph on Extended Irreversible Thermodynamics, a theory that goes beyond the classical theory of irreversible processes. In contrast to the classical approach, the basic variables describing the system are complemented by non-equilibrium quantities. The claims made for extended thermodynamics are confirmed by the kinetic theory of gases and statistical mechanics. The book covers a wide spectrum of applications, and also contains a thorough discussion of the foundations and the scope of the current theories on non-equilibrium thermodynamics. For this new edition, the authors critically revised existing material while taking into account the most recent developments in fast moving fields such as heat transport in micro- and nanosystems or fast solidification fronts in materials sciences. Several fundamental chapters have been revisited emphasizing physics and applications over mathematical derivations. Also, fundamental questions on the definition of non-equil...

  16. The Fly Printer - Extended

    DEFF Research Database (Denmark)

    Beloff, Laura; Klaus, Malena

    2016-01-01

    Artist talk / Work-in-progress What is the purpose of a machine or an artifact, like the Fly Printer, that is dislocated, that produces images that have no meaning, no instrumentality, that depict nothing in the world? The biological and the cultural are reunited in this apparatus as a possibilit...... the results. The extended version of the Fly Printer containing the technological perception and DNNs is a collaboration between Laura Beloff and Malene Theres Klaus...

  17. The dialogically extended mind

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Gangopadhyay, Nivedita; Tylén, Kristian

    2014-01-01

    , we argue that language enhances our cognitive capabilities in a much more radical way: The skilful engagement of public material symbols facilitates evolutionarily unprecedented modes of collective perception, action and reasoning (interpersonal synergies) creating dialogically extended minds. We...... relate our approach to other ideas about collective minds and review a number of empirical studies to identify the mechanisms enabling the constitution of interpersonal cognitive systems....

  18. Extended Theories of Gravitation

    Directory of Open Access Journals (Sweden)

    Fatibene Lorenzo

    2013-09-01

    Full Text Available Within the framework of extended theories of gravitation we shall discuss physical equivalences among different formalisms and classical tests. As suggested by the Ehlers-Pirani-Schild framework, the conformal invariance will be preserved and its effect on observational protocols discussed. Accordingly, we shall review standard tests showing how Palatini f(R-theories naturally passes solar system tests. Observation protocols will be discussed in this wider framework.

  19. Domain decomposition methods for hyperbolic problems

    Indian Academy of Sciences (India)

    In this paper a method is developed for solving hyperbolic initial boundary value problems in one space dimension using domain decomposition, which can be extended to problems in several space dimensions. We minimize a functional which is the sum of squares of the 2 norms of the residuals and a term which is the ...

  20. π-Extended Tetrathiafulvalenes

    DEFF Research Database (Denmark)

    Petersen, Johannes Fabritius

    This Ph.D.-thesis focuses on the synthesis and properties of various redox-active ¼-extended tetrathiafulvalenes. One class of molecules are so-called H-cruciform shaped molecules. In these molecules the formation of a central stilbene double bond is elucidated. Here it was found that the formation...... of the stilbene bond originates from preformation of a 1,3-dioxa-2-phospholane, formed by reaction between P(OEt)3 present under the reaction conditions and two aldehydes. Under the reaction conditions this 1,3-dioxa-2-phospholane can then be converted to the stilbene. These mechanistic studies lead...

  1. Extended spider cognition

    OpenAIRE

    Japyassú, Hilton F.; Laland, Kevin Neville

    2017-01-01

    HFJ received a visiting professor fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - Brazil) (PDE PDE232691/2014-2). Research supported in part by a Grant from the John Templeton Foundation to KNL. There is a tension between the conception of cognition as a central nervous system (CNS) process, and a view of cognition as extending towards the body or the contiguous environment. The centralised conception requires large or complex nervous systems to cope w...

  2. Domains of laminin

    DEFF Research Database (Denmark)

    Engvall, E; Wewer, U M

    1996-01-01

    Extracellular matrix molecules are often very large and made up of several independent domains, frequently with autonomous activities. Laminin is no exception. A number of globular and rod-like domains can be identified in laminin and its isoforms by sequence analysis as well as by electron...... microscopy. Here we present the structure-function relations in laminins by examination of their individual domains. This approach to viewing laminin is based on recent results from several laboratories. First, some mutations in laminin genes that cause disease have affected single laminin domains, and some...... laminin isoforms lack particular domains. These mutants and isoforms are informative with regard to the activities of the mutated and missing domains. These mutants and isoforms are informative with regard to the activities of the mutated and missing domains. Second, laminin-like domains have now been...

  3. Domain Specific Problem Solving.

    Science.gov (United States)

    Eade, Frank

    1989-01-01

    Outlines a possible framework for allowing teachers to explore how children learn mathematics. A mathematical modelling process and three domains, including content, process and pragmatic domain, are described. Twelve strategies for encouraging children to translate between the domains are suggested. (YP)

  4. Extending product modeling methods for integrated product development

    DEFF Research Database (Denmark)

    Bonev, Martin; Wörösch, Michael; Hauksdóttir, Dagný

    2013-01-01

    . Updated design requirements have then to be made explicit and mapped against the existing product architecture. In this paper, existing methods are adapted and extended through linking updated requirements to suitable product models. By combining several established modeling techniques, such as the DSM......Despite great efforts within the modeling domain, the majority of methods often address the uncommon design situation of an original product development. However, studies illustrate that development tasks are predominantly related to redesigning, improving, and extending already existing products...

  5. PDP: protein domain parser.

    Science.gov (United States)

    Alexandrov, Nickolai; Shindyalov, Ilya

    2003-02-12

    We have developed a program for automatic identification of domains in protein three-dimensional structures. Performance of the program was assessed by three different benchmarks: (i) by comparison with the expert-curated SCOP database of structural domains; (ii) by comparison with a collection of manual domain assignments; and (iii) by comparison with a set of 55 proteins, frequently used as a benchmark for automatic domain assignment. In all these benchmarks PDP identified domains correctly in more than 80% of proteins. http://123d.ncifcrf.gov/.

  6. Extending juvenility in grasses

    Energy Technology Data Exchange (ETDEWEB)

    Kaeppler, Shawn; de Leon Gatti, Natalia; Foerster, Jillian

    2017-04-11

    The present invention relates to compositions and methods for modulating the juvenile to adult developmental growth transition in plants, such as grasses (e.g. maize). In particular, the invention provides methods for enhancing agronomic properties in plants by modulating expression of GRMZM2G362718, GRMZM2G096016, or homologs thereof. Modulation of expression of one or more additional genes which affect juvenile to adult developmental growth transition such as Glossy15 or Cg1, in conjunction with such modulation of expression is also contemplated. Nucleic acid constructs for down-regulation of GRMZM2G362718 and/or GRMZM2G096016 are also contemplated, as are transgenic plants and products produced there from, that demonstrate altered, such as extended juvenile growth, and display associated phenotypes such as enhanced yield, improved digestibility, and increased disease resistance. Plants described herein may be used, for example, as improved forage or feed crops or in biofuel production.

  7. Extended Poisson Exponential Distribution

    Directory of Open Access Journals (Sweden)

    Anum Fatima

    2015-09-01

    Full Text Available A new mixture of Modified Exponential (ME and Poisson distribution has been introduced in this paper. Taking the Maximum of Modified Exponential random variable when the sample size follows a zero truncated Poisson distribution we have derived the new distribution, named as Extended Poisson Exponential distribution. This distribution possesses increasing and decreasing failure rates. The Poisson-Exponential, Modified Exponential and Exponential distributions are special cases of this distribution. We have also investigated some mathematical properties of the distribution along with Information entropies and Order statistics of the distribution. The estimation of parameters has been obtained using the Maximum Likelihood Estimation procedure. Finally we have illustrated a real data application of our distribution.

  8. Extending rational maps

    Science.gov (United States)

    Martin, Gaven J.

    We investigate when a rational endomorphism of the Riemann sphere overline{C} extends to a mapping of the upper half-space {H3 which is rational with respect to some measurable conformal structure. Such an extension has the property that it and all its iterates have uniformly bounded distortion. Such maps are called uniformly quasiregular. We show that, in the space of rational mappings of degree d , such an extension is possible in the structurally stable component where there is a single (attracting) component of the Fatou set and the Julia set is a Cantor set. We show that generally outside of this set no such extension is possible. In particular, polynomials can never admit such an extension.

  9. Reduced Extended MHD

    Science.gov (United States)

    Morrison, P. J.; Abdelhamid, H. M.; Grasso, D.; Hazeltine, R. D.; Lingam, M.; Tassi, E.

    2015-11-01

    Over the years various reduced fluid models have been obtained for modeling plasmas, with the goal of capturing important physics while maintaining computability. Such models have included the physics contained in various generalizations of Ohm's law, including Hall drift and electron inertia. In a recent publication it was shown that full 3D extended MHD is a Hamiltonian system by finding its noncanonical Poisson bracket. Subsequently, this bracket was shown to be derivable from that for Hall MHD by a series of remarkable transformations, which greatly simplifies the proof of the Jacobi identity and allows one to immediately obtain generalizations of the helicity and cross helicity. In this poster we use this structure to obtain exact reduced fluid models with the effects of full two-fluid theory. Results of numerical computations of collisionless reconnection using an exact reduced 4-field model will be presented and analytical comparisons of mode structure of previous reduced models will be made.

  10. Contribution of the CR domain to P-selectin lectin domain allostery by regulating the orientation of the EGF domain.

    Directory of Open Access Journals (Sweden)

    Shouqin Lü

    Full Text Available The allostery of P-selectin has been studied extensively with a focus on the Lec and EGF domains, whereas the contribution of the CR domain remains unclear. Here, molecular dynamics simulations (MDS combined with homology modeling were preformed to investigate the impact of the CR domain on P-selectin allostery. The results indicated that the CR domain plays a role in the allosteric dynamics of P-selectin in two ways. First, the CR1 domain tends to stabilize the low affinity of P-selectin during the equilibration processes with the transition inhibition from the S1 to S1' state by restraining the extension of the bent EGF orientation, or with the relaxation acceleration of the S2 state by promoting the bending of the extended EGF orientation. Second, the existence of CR domain increases intramolecular extension prior to complex separation, increasing the time available for the allosteric shift during forced dissociation with a prolonged bond duration. These findings further our understanding of the structure-function relationship of P-selectin with the enriched micro-structural bases of the CR domain.

  11. Influencia del Síndrome de apneas-hipopneas del Sueño (SAHS) y el tratamiento con presión positiva continua en la vía aérea (CPAP) en los niveles de presión arterial sistémica, grado de disfunción endotelial y expresión de la subunidad β1 del canal maxi-k+

    OpenAIRE

    Caballero Eraso, Candelaria

    2015-01-01

    INTRODUCCIÓN: El Síndrome de apneas-hipopneas del sueño (SAHS) se caracteriza por la aparición de episodios recurrentes de limitación del flujo aéreo, provocados por alteraciones anatómico-funcionales de la vía aérea superior, que producen un colapso parcial o total de la misma durante el sueño. La importancia del diagnóstico del SAHS radica, por un lado, en el hecho de que se dispone de un tratamiento eficaz par...

  12. Domains and Naive Theories.

    Science.gov (United States)

    Gelman, Susan A; Noles, Nicholaus S

    2011-09-01

    Human cognition entails domain-specific cognitive processes that influence memory, attention, categorization, problem-solving, reasoning, and knowledge organization. This review examines domain-specific causal theories, which are of particular interest for permitting an examination of how knowledge structures change over time. We first describe the properties of commonsense theories, and how commonsense theories differ from scientific theories, illustrating with children's classification of biological and non-biological kinds. We next consider the implications of domain-specificity for broader issues regarding cognitive development and conceptual change. We then examine the extent to which domain-specific theories interact, and how people reconcile competing causal frameworks. Future directions for research include examining how different content domains interact, the nature of theory change, the role of context (including culture, language, and social interaction) in inducing different frameworks, and the neural bases for domain-specific reasoning.

  13. 2230_IJBCS-Article-Cyriaque Debey Sah

    African Journals Online (AJOL)

    hp

    décroissant, les tissus mous, le site urinaire, le sang et le site opératoire. .... Enregistrement, Compilation, Analyse); Document faisant état du bilan de la surveillance). 1 ... site urinaire. Par ailleurs, Enterobacter cloacae et. Klebsiella pneumoniae étaient souvent identifiés dans le sang (Figure 1). Sensibilité des bactéries aux ...

  14. Dual beam encoded extended fractional Fourier transform security ...

    Indian Academy of Sciences (India)

    security hologram can only be read through a key hologram. Key hologram also facilitates in-built ... ers as holographic images from hologram can be captured easily with advanced opto-electronic tools and a new ... significant feature of extended fractional Fourier domain optical image encryption benefits from its additional ...

  15. Magnetic domains the analysis of magnetic microstructures

    CERN Document Server

    Hubert, Alex

    1998-01-01

    The book gives a systematic and comprehensive survey of the complete area of magnetic microstructures. It reaches from micromagnetism of nanoparticles to complex structures of extended magnetic materials. The book starts with a comprehensive evaluation of traditional and modern experimental methods for the observation of magnetic domains and continues with the treatment of important methods for the theoretical analysis of magnetic microcstructures. A survey of the necessary techniques in materials characterization is given. The book offers an observation and analysis of magnetic domains in all

  16. Evolutionary history of the TBP-domain superfamily.

    Science.gov (United States)

    Brindefalk, Björn; Dessailly, Benoit H; Yeats, Corin; Orengo, Christine; Werner, Finn; Poole, Anthony M

    2013-03-01

    The TATA binding protein (TBP) is an essential transcription initiation factor in Archaea and Eucarya. Bacteria lack TBP, and instead use sigma factors for transcription initiation. TBP has a symmetric structure comprising two repeated TBP domains. Using sequence, structural and phylogenetic analyses, we examine the distribution and evolutionary history of the TBP domain, a member of the helix-grip fold family. Our analyses reveal a broader distribution than for TBP, with TBP-domains being present across all three domains of life. In contrast to TBP, all other characterized examples of the TBP domain are present as single copies, primarily within multidomain proteins. The presence of the TBP domain in the ubiquitous DNA glycosylases suggests that this fold traces back to the ancestor of all three domains of life. The TBP domain is also found in RNase HIII, and phylogenetic analyses show that RNase HIII has evolved from bacterial RNase HII via TBP-domain fusion. Finally, our comparative genomic screens confirm and extend earlier reports of proteins consisting of a single TBP domain among some Archaea. These monopartite TBP-domain proteins suggest that this domain is functional in its own right, and that the TBP domain could have first evolved as an independent protein, which was later recruited in different contexts.

  17. Supersymmetric domain walls

    NARCIS (Netherlands)

    Bergshoeff, Eric A.; Kleinschmidt, Axel; Riccioni, Fabio

    2012-01-01

    We classify the half-supersymmetric "domain walls," i.e., branes of codimension one, in toroidally compactified IIA/IIB string theory and show to which gauged supergravity theory each of these domain walls belong. We use as input the requirement of supersymmetric Wess-Zumino terms, the properties of

  18. GlycoDomainViewer

    DEFF Research Database (Denmark)

    Joshi, Hiren J; Jørgensen, Anja; Schjoldager, Katrine T

    2018-01-01

    The GlycoDomainViewer is a bioinformatic tool to aid in the mining of glycoproteomic data sets from different sources and facilitate incorporation of glycosylation into studies of protein structure and function. We present a version 2.0 of GlycoDomainViewer incorporating a number of advanced feat...

  19. Cholesterol Domains Enhance Transfection

    Science.gov (United States)

    Betker, Jamie L.; Kullberg, Max; Gomez, Joe; Anchordoquy, Thomas J.

    2014-01-01

    The formation of cholesterol domains in lipoplexes has been associated with enhanced serum stability and transfection rates both in cell culture and in vivo. This study utilizes the ability of saturated phosphatidylcholines to promote the formation of cholesterol domains at much lower cholesterol contents than have been utilized in previous work. The results show that lipoplexes with identical cholesterol and cationic lipid contents exhibit significantly improved transfection efficiencies when a domain is present, consistent with previous work. In addition, studies assessing transfection rates in the absence of serum demonstrate that the ability of domains to enhance transfection is not dependent on interactions with serum proteins. Consistent with this hypothesis, characterization of the adsorbed proteins composing the corona of these lipoplex formulations did not reveal a correlation between transfection and the adsorption of a specific protein. Finally, we show that the interaction with serum proteins can promote domain formation in some formulations, and thereby result in enhanced transfection only after serum exposure. PMID:23557286

  20. Domain decomposition methods for mortar finite elements

    Energy Technology Data Exchange (ETDEWEB)

    Widlund, O.

    1996-12-31

    In the last few years, domain decomposition methods, previously developed and tested for standard finite element methods and elliptic problems, have been extended and modified to work for mortar and other nonconforming finite element methods. A survey will be given of work carried out jointly with Yves Achdou, Mario Casarin, Maksymilian Dryja and Yvon Maday. Results on the p- and h-p-version finite elements will also be discussed.

  1. Dynamic dependence to domain wall propagation through artificial spin ice

    Science.gov (United States)

    Burn, D. M.; Chadha, M.; Branford, W. R.

    2017-03-01

    Domain wall propagation dynamics has been studied in nanostructured artificial kagome spin-ice structures. A stripline circuit has been used to provide localized pulsed magnetic fields within the artificial spin-ice (ASI) structure. This provides control of the system through electrically assisted domain wall nucleation events. Synchronization of the pulsed fields with additional global magnetic fields and the use of a focused magneto-optical Kerr effect magnetometer allows our experiments to probe the domain wall transit through an extended ASI structure. We find that the propagation distance depends on the driving field revealing field-driven properties of domain walls below their intrinsic nucleation field.

  2. Conceptualisation des espaces sahéliens chez les auteurs arabes du Moyen Âge Conceptualization of the Sahelian spaces by the Arab authors in the Middle Ages

    Directory of Open Access Journals (Sweden)

    Jean-Charles Ducène

    2013-05-01

    Full Text Available Si les auteurs arabes médiévaux constituent une source unique pour la connaissance des espaces sahéliens, il n’en reste pas moins que ces observateurs définissent ces régions selon les concepts géographiques ou ethniques du moment (ixe–xe siècle. Les principes directeurs de la géographie de l’époque imposent une définition mathématique et déterminent une ethnographie pour ces contrées, alors que les conditions naturelles semblent légitimer cette vision qui établit une forte différenciation entre les populations du Nord et du Sud du Sahara, ce dernier espace étant plus un lieu de transition qu’une barrière. Ces cadres une fois constitués, les informations recueillies viennent y trouver place sans entraîner une redéfinition de l’ensemble ou en préciser les contours, et ceci malgré la pénétration de l’islam et la densification des relations entre les Arabes et le bilād al-Sūdān, à partir du xiie siècle. Les toponymes se multiplient ainsi que les « observations » culturelles, celles-ci fondées sur le principe que plus le comportement s’éloigne de ce que connaît l’observateur, plus il est remarquable.The medieval Arab authors are an invaluable source for the knowledge of Sahelian spaces. However, these observers defined these lands according to geographical or ethnic concepts, fitting with the spirit of their time (9th-10th centuries. The guidelines of the medieval geography impose a mathematical definition to the space and determine an ethnography for these peoples, while natural conditions seemed to legitimate this vision, that established a huge differentiation between the populations located North and South of the Sahara. This desert was seen as a transitional space rather than a barrier. Once established, this framework didn’t move in spite of the islamization of these lands and the increasing contacts between the Arabs and the bilād al-Sūdān in the 12th century. The toponymy becomes

  3. Extended mind and after: socially extended mind and actor-network.

    Science.gov (United States)

    Kono, Tetsuya

    2014-03-01

    The concept of extended mind has been impressively developed over the last 10 years by many philosophers and cognitive scientists. The extended mind thesis (EM) affirms that the mind is not simply ensconced inside the head, but extends to the whole system of brain-body-environment. Recently, some philosophers and psychologists try to adapt the idea of EM to the domain of social cognition research. Mind is socially extended (SEM). However, EM/SEM theory has problems to analyze the interactions among a subject and its surroundings with opposition, antagonism, or conflict; it also tends to think that the environment surrounding the subject is passive or static, and to neglect the power of non-human actants to direct and regulate the human subject. In these points, actor-network theory (ANT) proposed by Latour and Callon is more persuasive, while sharing some important ideas with EM/SEM theory. Actor-network is a hybrid community which is composed of a series of heterogeneous elements, animate and inanimate for a certain period of time. I shall conclude that EM/SEM could be best analyzed as a special case of actor-network. EM/SEM is a system which can be controlled by a human agent alone. In order to understand collective behavior, philosophy and psychology have to study the actor-network in which human individuals are situated.

  4. Extending cosmology: the metric approach

    OpenAIRE

    Mendoza, S.

    2012-01-01

    Comment: 2012, Extending Cosmology: The Metric Approach, Open Questions in Cosmology; Review article for an Intech "Open questions in cosmology" book chapter (19 pages, 3 figures). Available from: http://www.intechopen.com/books/open-questions-in-cosmology/extending-cosmology-the-metric-approach

  5. On core stability and extendability

    OpenAIRE

    Shellshear, Evan

    2011-01-01

    This paper investigates conditions under which the core of a TU cooperative game is stable. In particular the author extends the idea of extendability to find new conditions under which the core is stable. It is also shown that these new conditions are not necessary for core stability.

  6. Conserved Domain Database (CDD)

    Data.gov (United States)

    U.S. Department of Health & Human Services — CDD is a protein annotation resource that consists of a collection of well-annotated multiple sequence alignment models for ancient domains and full-length proteins.

  7. Movement of elongation factor G between compact and extended conformations.

    Science.gov (United States)

    Salsi, Enea; Farah, Elie; Netter, Zoe; Dann, Jillian; Ermolenko, Dmitri N

    2015-01-30

    Previous structural studies suggested that ribosomal translocation is accompanied by large interdomain rearrangements of elongation factor G (EF-G). Here, we follow the movement of domain IV of EF-G relative to domain II of EF-G using ensemble and single-molecule Förster resonance energy transfer. Our results indicate that ribosome-free EF-G predominantly adopts a compact conformation that can also, albeit infrequently, transition into a more extended conformation in which domain IV moves away from domain II. By contrast, ribosome-bound EF-G predominantly adopts an extended conformation regardless of whether it is interacting with pretranslocation ribosomes or with posttranslocation ribosomes. Our data suggest that ribosome-bound EF-G may also occasionally sample at least one more compact conformation. GTP hydrolysis catalyzed by EF-G does not affect the relative stability of the observed conformations in ribosome-free and ribosome-bound EF-G. Our data support a model suggesting that, upon binding to a pretranslocation ribosome, EF-G moves from a compact to a more extended conformation. This transition is not coupled to but likely precedes both GTP hydrolysis and mRNA/tRNA translocation. Copyright © 2014. Published by Elsevier Ltd.

  8. Movement of Elongation Factor G between Compact and Extended Conformations

    Science.gov (United States)

    Salsi, Enea; Farah, Elie; Netter, Zoe; Dann, Jillian; Ermolenko, Dmitri N.

    2014-01-01

    Previous structural studies suggested that ribosomal translocation is accompanied by large interdomain rearrangements of elongation factor G (EF-G). Here, we follow the movement of domain IV of EF-G relative to domain II of EF-G using ensemble and single-molecule Förster resonance energy transfer (smFRET). Our results indicate that ribosome-free EF-G predominantly adopts a compact conformation that can also, albeit infrequently, transition into a more extended conformation in which domain IV moves away from domain II. By contrast, ribosome-bound EF-G predominantly adopts an extended conformation regardless of whether it is interacting with pre- or posttranslocation ribosomes. Our data suggest that ribosome-bound EF-G may also occasionally sample at least one more compact conformation. GTP hydrolysis catalyzed by EF-G does not affect the relative stability of the observed conformations in ribosome-free and ribosome-bound EF-G. Our data support a model suggesting that, upon binding to a pretranslocation ribosome, EF-G moves from a compact to a more extended conformation. This transition is not coupled to, but likely precedes both GTP hydrolysis and mRNA/tRNA translocation. PMID:25463439

  9. Extended Active Disturbance Rejection Controller

    Science.gov (United States)

    Gao, Zhiqiang (Inventor); Tian, Gang (Inventor)

    2016-01-01

    Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

  10. Large stable magnetic domains

    Science.gov (United States)

    Pulliam, G. R.; Ross, W. E.; MacNeal, B.; Bailey, R. F.

    1982-03-01

    Large, thin-film single domain areas have been observed, in the absence of a bias field, in garnets with magnetization perpendicular to the film plane.1,2 The domain stability in the work by Krumme1 was attributed to a combination of low saturation magnetization and a low Curie temperature. Uchishiba2 relates the stability in his double layer system to appropriate anisotropy fields in one layer compared to the magnetization in the other layer. A more complete model for large domain stability in a bias field free environment is given in this work. Three distinct stability regimes are predicted by the model and all have been observed experimentally. Areas 3.5-cm in diameter have been made into stable single domains. This was achieved in a material showing a zero bias strip width of 4.5 μm. The single domain diameter was, therefore, 7500 times the equilibrium energy domain width. The technique developed and the model have led to a new means for observing magnetic defects. More importantly, it also offers a means for measuring the strength of the defects. Possible applications of the model are also discussed.

  11. Individual globular domains and domain unfolding visualized in overstretched titin molecules with atomic force microscopy.

    Directory of Open Access Journals (Sweden)

    Zsolt Mártonfalvi

    Full Text Available Titin is a giant elastomeric protein responsible for the generation of passive muscle force. Mechanical force unfolds titin's globular domains, but the exact structure of the overstretched titin molecule is not known. Here we analyzed, by using high-resolution atomic force microscopy, the structure of titin molecules overstretched with receding meniscus. The axial contour of the molecules was interrupted by topographical gaps with a mean width of 27.7 nm that corresponds well to the length of an unfolded globular (immunoglobulin and fibronectin domain. The wide gap-width distribution suggests, however, that additional mechanisms such as partial domain unfolding and the unfolding of neighboring domain multimers may also be present. In the folded regions we resolved globules with an average spacing of 5.9 nm, which is consistent with a titin chain composed globular domains with extended interdomain linker regions. Topographical analysis allowed us to allocate the most distal unfolded titin region to the kinase domain, suggesting that this domain systematically unfolds when the molecule is exposed to overstretching forces. The observations support the prediction that upon the action of stretching forces the N-terminal ß-sheet of the titin kinase unfolds, thus exposing the enzyme's ATP-binding site and hence contributing to the molecule's mechanosensory function.

  12. Autopoiesis + extended cognition + nature = can buildings think?

    Science.gov (United States)

    Dollens, Dennis

    2015-01-01

    To incorporate metabolic, bioremedial functions into the performance of buildings and to balance generative architecture's dominant focus on computational programming and digital fabrication, this text first discusses hybridizing Maturana and Varela's biological theory of autopoiesis with Andy Clark's hypothesis of extended cognition. Doing so establishes a procedural protocol to research biological domains from which design could source data/insight from biosemiotics, sensory plants, and biocomputation. I trace computation and botanic simulations back to Alan Turing's little-known 1950s Morphogenetic drawings, reaction-diffusion algorithms, and pioneering artificial intelligence (AI) in order to establish bioarchitecture's generative point of origin. I ask provocatively, Can buildings think? as a question echoing Turing's own, "Can machines think?"

  13. Bellman goes Relational (extended abstract)

    NARCIS (Netherlands)

    van Otterlo, M.; Kersting, Kristian; De Raedt, Luc; Verbrugge, R.; Taatgen, N.; Schonmaker, L.

    2004-01-01

    We introduce REBEL, a relational Bellman update operator that can be used for Markov Decision Processes in - possibly infinite - relational domains. Using REBEL we develop a relational value iteration algorithm.

  14. Domains in Ferroelectric Nanostructures

    Science.gov (United States)

    Gregg, Marty

    2010-03-01

    Ferroelectric materials have great potential in influencing the future of small scale electronics. At a basic level, this is because ferroelectric surfaces are charged, and so interact strongly with charge-carrying metals and semiconductors - the building blocks for all electronic systems. Since the electrical polarity of the ferroelectric can be reversed, surfaces can both attract and repel charges in nearby materials, and can thereby exert complete control over both charge distribution and movement. It should be no surprise, therefore, that microelectronics industries have already looked very seriously at harnessing ferroelectric materials in a variety of applications, from solid state memory chips (FeRAMs) to field effect transistors (FeFETs). In all such applications, switching the direction of the polarity of the ferroelectric is a key aspect of functional behavior. The mechanism for switching involves the field-induced nucleation and growth of domains. Domain coarsening, through domain wall propagation, eventually causes the entire ferroelectric to switch its polar direction. It is thus the existence and behavior of domains that determine the switching response, and ultimately the performance of the ferroelectric device. A major issue, associated with the integration of ferroelectrics into microelectronic devices, has been that the fundamental properties associated with ferroelectrics, when in bulk form, appear to change quite dramatically and unpredictably when at the nanoscale: new modes of behaviour, and different functional characteristics from those seen in bulk appear. For domains, in particular, the proximity of surfaces and boundaries have a dramatic effect: surface tension and depolarizing fields both serve to increase the equilibrium density of domains, such that minor changes in scale or morphology can have major ramifications for domain redistribution. Given the importance of domains in dictating the overall switching characteristics of a device

  15. Extending gene ontology in the context of extracellular RNA and vesicle communication

    NARCIS (Netherlands)

    Cheung, Kei-Hoi; Keerthikumar, Shivakumar; Roncaglia, Paola; Subramanian, Sai Lakshmi; Roth, Matthew E; Samuel, Monisha; Anand, Sushma; Gangoda, Lahiru; Gould, Stephen; Alexander, Roger; Galas, David; Gerstein, Mark B; Hill, Andrew F; Kitchen, Robert R; Lötvall, Jan; Patel, Tushar; Procaccini, Dena C; Quesenberry, Peter; Rozowsky, Joel; Raffai, Robert L; Shypitsyna, Aleksandra; Su, Andrew I; Théry, Clotilde; Vickers, Kasey; Wauben, Marca H M|info:eu-repo/dai/nl/112675735; Mathivanan, Suresh; Milosavljevic, Aleksandar; Laurent, Louise C

    2016-01-01

    BACKGROUND: To address the lack of standard terminology to describe extracellular RNA (exRNA) data/metadata, we have launched an inter-community effort to extend the Gene Ontology (GO) with subcellular structure concepts relevant to the exRNA domain. By extending GO in this manner, the exRNA

  16. Learning from Experts: Fostering Extended Thinking in the Early Phases of the Design Process

    Science.gov (United States)

    Haupt, Grietjie

    2015-01-01

    Empirical evidence on the way in which expert designers from different domains cognitively connect their internal processes with external resources is presented in the context of an extended cognition model. The article focuses briefly on the main trends in the extended design cognition theory and in particular on recent trends in information…

  17. Domain Theory for Concurrency

    DEFF Research Database (Denmark)

    Nygaard, Mikkel

    Concurrent computation can be given an abstract mathematical treatment very similar to that provided for sequential computation by domain theory and denotational semantics of Scott and Strachey. A simple domain theory for concurrency is presented. Based on a categorical model of linear logic and ...... towards more expressive languages than HOPLA and Affine HOPLA—in particular concerning extensions to cover independence models. The thesis concludes with a discussion of related work towards a fully fledged domain theory for concurrency.......Concurrent computation can be given an abstract mathematical treatment very similar to that provided for sequential computation by domain theory and denotational semantics of Scott and Strachey. A simple domain theory for concurrency is presented. Based on a categorical model of linear logic...... equivalence. One language, called HOPLA for Higher-Order Process LAnguage, derives from an exponential of linear logic. It can be viewed as an extension of the simply-typed lambda calculus with CCS-like nondeterministic sum and prefix operations, in which types express the form of computation path of which...

  18. Homogenization of some evolution problems in domains with small holes

    Directory of Open Access Journals (Sweden)

    Bituin Cabarrubias

    2016-07-01

    Full Text Available This article concerns the asymptotic behavior of the wave and heat equations in periodically perforated domains with small holes and Dirichlet conditions on the boundary of the holes. In the first part we extend to time-dependent functions the periodic unfolding method for domains with small holes introduced in [6]. Therein, the method was applied to the study of elliptic problems with oscillating coefficients in domains with small holes, recovering the homogenization result with a "strange term" originally obtained in [11] for the Laplacian. In the second part we obtain some homogenization results for the wave and heat equations with oscillating coefficients in domains with small holes. The results concerning the wave equation extend those obtained in [12] for the case where the elliptic part of the operator is the Laplacian.

  19. Thermoplastic Polyurethanes with Isosorbide Chain Extender

    Energy Technology Data Exchange (ETDEWEB)

    Javni, Ivan; Bilic, Olivera; Bilic, Nikola; Petrovic, Zoran; Eastwood, Eric; Zhang, Fan; Ilavsky, Jan

    2015-12-15

    Isosorbide, a renewable diol derived from starch, was used alone or in combination with butane diol (BD) as the chain extender in two series of thermoplastic polyurethanes (TPU) with 50 and 70% polytetramethylene ether glycol (PTMEG) soft segment concentration (SSC), respectively. In the synthesized TPUs, the hard segment composition was systematically varied in both series following BD/isosorbide molar ratios of 100 : 0; 75 : 25; 50 : 50; 25 : 75, and 0 : 100 to examine in detail the effect of chain extenders on properties of segmented polyurethane elastomers with different morphologies. We found that polyurethanes with 50% SSC were hard elastomers with Shore D hardness of around 50, which is consistent with assumed co-continuous morphology. Polymers with 70% SSC displayed lower Shore A hardness of 74–79 (Shore D around 25) as a result of globular hard domains dispersed in the soft matrix. Insertion of isosorbide increased rigidity, melting point and glass transition temperature of hard segments and tensile strength of elastomers with 50% SSC. These effects were weaker or non-existent in 70% SSC series due to the short hard segments and low content of isosorbide. We also found that the thermal stability was lowered by increasing isosorbide content in both series.

  20. Extending Conceptual Schemas with Business Process Information

    Directory of Open Access Journals (Sweden)

    Marco Brambilla

    2010-01-01

    Full Text Available The specification of business processes is becoming a more and more critical aspect for organizations. Such processes are specified as workflow models expressing the logical precedence among the different business activities (i.e., the units of work. Typically, workflow models are managed through specific subsystems, called workflow management systems, to ensure a consistent behavior of the applications with respect to the organization business process. However, for small organizations and/or simple business processes, the complexity and capabilities of these dedicated workflow engines may be overwhelming. In this paper, we therefore, advocate for a different and lightweight approach, consisting in the integration of the business process specification within the system conceptual schema. We show how a workflow-extended conceptual schema can be automatically obtained, which serves both to enforce the organization business process and to manage all its relevant domain data in a unified way. This extended model can be directly processed with current CASE tools, for instance, to generate an implementation of the system (including its business process in any technological platform.

  1. Topological defects in extended inflation

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, E.J. (Department of Physics, University of Sussex, Brighton BN1 9QH (United Kingdom)); Kolb, E.W. (NASA/Fermilab Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, IL (USA) Department of Astronomy and Astrophysics, Enrico Fermi Institute, The University of Chicago, Chicago, IL (USA)); Liddle, A.R. (Astronomy Centre, Department of Physics, University of Sussex, Brighton (United Kingdom))

    1990-10-15

    We consider the production of topological defects, especially cosmic strings, in extended-inflation models. In extended inflation, the Universe passes through a first-order phase transition via bubble percolation, which naturally allows defects to form at the end of inflation. The correlation length, which determines the number density of the defects, is related to the mean size of the bubbles when they collide. This mechanism allows a natural combination of inflation and large-scale structure via cosmic strings.

  2. Topological defects in extended inflation

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, E.J. (Sussex Univ., Brighton (UK). Dept. of Physics); Kolb, E.W. (Fermi National Accelerator Lab., Batavia, IL (USA) Chicago Univ., IL (USA). Enrico Fermi Inst.); Liddle, A.R. (Sussex Univ., Brighton (UK). Astronomy Centre)

    1990-04-01

    We consider the production of topological defects, especially cosmic strings, in extended inflation models. In extended inflation, the Universe passes through a first-order phase transition via bubble percolation, which naturally allows defects to form at the end of inflation. The correlation length, which determines the number density of the defects, is related to the mean size of bubbles when they collide. This mechanism allows a natural combination of inflation and large-scale structure via cosmic strings. 18 refs.

  3. Extended lactation in dairy cows

    DEFF Research Database (Denmark)

    Sorensen, Annette; Muir, D. Donald; Knight, Christopher Harold

    2008-01-01

    of the lactation, protein and fat percentages increasing and lactose percentage decreasing, irrespective of treatment. The quality of the milk for processing into cheese, fermented products, heat-treated products and cream liqueurs was assessed by calculation of casein number (casein protein as a proportion...... interventions, the results lend support to the economic arguments in favour of extended lactation cycles. The likely welfare benefits of extended lactation are also discussed....

  4. Extender for securing a closure

    Science.gov (United States)

    Thomas, II, Patrick A.

    2012-10-02

    An apparatus for securing a closure such as door or a window that opens and closes by movement relative to a fixed structure such as a wall or a floor. Many embodiments provide a device for relocating a padlock from its normal location where it secures a fastener (such as a hasp) to a location for the padlock that is more accessible for locking and unlocking the padlock. Typically an extender is provided, where the extender has a hook at a first end that is disposed through the eye of the staple of the hasp, and at an opposing second end the extender has an annulus, such as a hole in the extender or a loop or ring affixed to the extender. The shackle of the padlock may be disposed through the annulus and may be disposed through the eye of a second staple to secure the door or window in a closed or open position. Some embodiments employ a rigid sheath to enclose at least a portion of the extender. Typically the rigid sheath has an open state where the hook is exposed outside the sheath and a closed state where the hook is disposed within the sheath.

  5. Domain Generalization and Adaptation using Low Rank Exemplar SVMs.

    Science.gov (United States)

    Li, Wen; Xu, Zheng; Xu, Dong; Dai, Dengxin; Van Gool, Luc

    2017-05-16

    Domain adaptation between diverse source and target domains is a challenging research problem, especially in the real-world visual recognition tasks where the images and videos consist of significant variations in viewpoints, illuminations, qualities, etc. In this paper, we propose a new approach for domain generalization and domain adaptation based on exemplar SVMs. Specifically, we decompose the source domain into many subdomains, each of which contains only one positive training sample and all negative samples. Each subdomain is relatively less diverse, and is expected to have a simpler distribution. By training one exemplar SVM for each subdomain, we obtain a set of exemplar SVMs. To further exploit the inherent structure of source domain, we introduce a nuclear-norm based regularizer into the objective function in order to enforce the exemplar SVMs to produce a low-rank output on training samples. In the prediction process, the confident exemplar SVM classifiers are selected and reweigted according to the distribution mismatch between each subdomain and the test sample in the target domain. We formulate our approach based on the logistic regression and least square SVM algorithms, which are referred to as low rank exemplar SVMs (LRE-SVMs) and low rank exemplar least square SVMs (LRE-LSSVMs), respectively. A fast algorithm is also developed for accelerating the training of LRE-LSSVMs. We further extend Domain Adaptation Machine (DAM) to learn an optimal target classifier for domain adaptation, and show that our approach can also be applied to domain adaptation with evolving target domain, where the target data distribution is gradually changing. The comprehensive experiments for object recognition and action recognition demonstrate the effectiveness of our approach for domain generalization and domain adaptation with fixed and evolving target domains.

  6. Broadband absorption through extended resonance modes in random metamaterials

    Energy Technology Data Exchange (ETDEWEB)

    Hao, J.; Niemiec, R.; Lheurette, É.; Lippens, D. [Institut d' Électronique de Microélectronique et Nanotechnologies, IEMN-UMR CNRS 8520, Université de Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d' Ascq Cedex (France); Burgnies, L. [Institut d' Électronique de Microélectronique et Nanotechnologies, IEMN-UMR CNRS 8520, Université de Lille 1, Avenue Poincaré, BP 60069, 59652 Villeneuve d' Ascq Cedex (France); Université du Littoral Côte d' Opale, Rue Ferdinand Buisson, CS 80699, 62228 Calais cedex (France)

    2016-05-21

    The properties of disordered metamaterial absorbers are analyzed on the basis of numerical simulations and experimental characterizations. A broadening of the absorption spectrum is clearly evidenced. This effect is the consequence of both the coupling between nearby resonators leading to the occurrence of extended magnetic resonance modes and the interconnection of elementary particles yielding the definition of resonating clusters. The angular robustness of the absorbing structure under oblique incidence is also demonstrated for a wide domain of angles.

  7. Domain-Specific Multimodeling

    DEFF Research Database (Denmark)

    Hessellund, Anders

    the overall level of abstraction. It does, however, also introduce a new problem of coordinating multiple different languages in a single system. We call this problem the coordination problem. In this thesis, we present the coordination method for domain-specific multimodeling that explicitly targets...

  8. Charged Domain Walls

    OpenAIRE

    Campanelli, L.; Cea, P.; Fogli, G. L.; Tedesco, L.

    2003-01-01

    In this paper we investigate Charged Domain Walls (CDW's), topological defects that acquire surface charge density $Q$ induced by fermion states localized on the walls. The presence of an electric and magnetic field on the walls is also discussed. We find a relation in which the value of the surface charge density $Q$ is connected with the existence of such topological defects.

  9. Domain: Labour market

    NARCIS (Netherlands)

    Oude Mulders, J.; Wadensjö, E.; Hasselhorn, H.M.; Apt, W.

    This domain chapter is dedicated to summarize research on the effects of labour market contextual factors on labour market participation of older workers (aged 50+) and identify research gaps. While employment participation and the timing of (early) retirement is often modelled as an individual

  10. The framing of scientific domains

    DEFF Research Database (Denmark)

    Dam Christensen, Hans

    2014-01-01

    Purpose: By using the UNISIST models this article argues for the necessity of domain analysis in order to qualify scientific information seeking. The models better understanding of communication processes in a scientific domain and embraces the point that domains are always both unstable over time...... domains, and UNISIST helps understanding this navigation. Design/methodology/approach The UNISIST models are tentatively applied to the domain of art history at three stages, respectively two modern, partially overlapping domains, as well as an outline of an art historical domain anno c1820...... as according to the agents that are charting them. As such, power in a Foucauldian sense is unavoidable in outlining a domain. Originality/value 1. The UNISIST models are applied to the domain of art history; and 2. the article discusses the instability of a scientific domain as well as, at the same time...

  11. Viability of bull semen extended with commercial semen extender ...

    African Journals Online (AJOL)

    Andrea Raseona

    Abstract. The aim of this study was to evaluate the viability of bull spermatozoa diluted with commercial semen extender and two culture media stored at controlled room temperature (24 °C) for 72 hours. Two Nguni bulls were used for semen collection with the aid of an electro-ejaculator. After macroscopic evaluation ...

  12. Extended cognition in science communication.

    Science.gov (United States)

    Ludwig, David

    2014-11-01

    The aim of this article is to propose a methodological externalism that takes knowledge about science to be partly constituted by the environment. My starting point is the debate about extended cognition in contemporary philosophy and cognitive science. Externalists claim that human cognition extends beyond the brain and can be partly constituted by external devices. First, I show that most studies of public knowledge about science are based on an internalist framework that excludes the environment we usually utilize to make sense of science and does not allow the possibility of extended knowledge. In a second step, I argue that science communication studies should adopt a methodological externalism and accept that knowledge about science can be partly realized by external information resources such as Wikipedia. © The Author(s) 2013.

  13. Single channel speech enhancement in the modulation domain: New insights in the modulation channel selection framework

    DEFF Research Database (Denmark)

    Boldt, Jesper B.; Bertelsen, Andreas Thelander; Gran, Fredrik

    2015-01-01

    Recently, the ideal binary mask has been introduced in the modulation domain by extending the ideal channel selection method to modulation channel selection [1]. This new method shows substantial improvement in speech intelligibility but less than its predecessor despite the higher complexity. Here......, we extend the previous finding from [1] and provide a more direct comparison of binary masking in the modulation domain with binary masking in the time-frequency domain. Subjective and objective evaluations are performed and provide additional insight into modulation domain processing....

  14. Exclusion Bounds for Extended Anyons

    Science.gov (United States)

    Larson, Simon; Lundholm, Douglas

    2017-08-01

    We introduce a rigorous approach to the many-body spectral theory of extended anyons, that is quantum particles confined to two dimensions that interact via attached magnetic fluxes of finite extent. Our main results are many-body magnetic Hardy inequalities and local exclusion principles for these particles, leading to estimates for the ground-state energy of the anyon gas over the full range of the parameters. This brings out further non-trivial aspects in the dependence on the anyonic statistics parameter, and also gives improvements in the ideal (non-extended) case.

  15. Wavefield Extrapolation in Pseudo-depth Domain

    KAUST Repository

    Ma, Xuxin

    2011-12-11

    Wave-equation based seismic migration and inversion tools are widely used by the energy industry to explore hydrocarbon and mineral resources. By design, most of these techniques simulate wave propagation in a space domain with the vertical axis being depth measured from the surface. Vertical depth is popular because it is a straightforward mapping of the subsurface space. It is, however, not computationally cost-effective because the wavelength changes with local elastic wave velocity, which in general increases with depth in the Earth. As a result, the sampling per wavelength also increases with depth. To avoid spatial aliasing in deep fast media, the seismic wave is oversampled in shallow slow media and therefore increase the total computation cost. This issue is effectively tackled by using the vertical time axis instead of vertical depth. This is because in a vertical time representation, the "wavelength" is essentially time period for vertical rays. This thesis extends the vertical time axis to the pseudo-depth axis, which features distance unit while preserving the properties of the vertical time representation. To explore the potentials of doing wave-equation based imaging in the pseudo-depth domain, a Partial Differential Equation (PDE) is derived to describe acoustic wave in this new domain. This new PDE is inherently anisotropic because the use of a constant vertical velocity to convert between depth and vertical time. Such anisotropy results in lower reflection coefficients compared with conventional space domain modeling results. This feature is helpful to suppress the low wavenumber artifacts in reverse-time migration images, which are caused by the widely used cross-correlation imaging condition. This thesis illustrates modeling acoustic waves in both conventional space domain and pseudo-depth domain. The numerical tool used to model acoustic waves is built based on the lowrank approximation of Fourier integral operators. To investigate the potential

  16. Space Domain Awareness for Manned GEO Servicing

    Science.gov (United States)

    Blake, T.

    2010-09-01

    The Defense Advanced Research Projects Agency (DARPA) is embarking on a joint program to service spacecraft in Geosynchronous (GEO) Orbit. This ambitious program, known as R5 (Rendezvous, Refuel, Refurbish, Repair, and Reposition), will develop the technologies required to extend the life of billions of dollars of invested in building, launching and operating GEO spacecraft. Inherent in the R5 program, is the need for high quality awareness of the space domain at GEO. Servicing non-operational spacecraft in GEO will require enhanced debris detect/track and space weather monitoring for crew safety, as well as high resolution characterization of the spacecraft to understand the status of the spacecraft to manifest the repair mission. This paper will briefly describe the GEO space domain sensor and data processing requirements to support the R5 program and outline DARPA’s program plans to develop these capabilities. Distribution Statement A (Approved for Public Release, Distribution Unlimited). DISTAR case 15410.

  17. Time-domain boundary conditions for outdoor ground surfaces

    Science.gov (United States)

    Collier, Sandra L.; Ostashev, Vladimir E.; Wilson, D. Keith; Marlin, David H.

    2003-10-01

    Finite-difference time-domain techniques are promising for detailed dynamic simulations of sound propagation in complex atmospheric environments. Success of such simulations requires the development of new techniques to accurately handle the reflective and absorptive properties of a porous ground. One method of treating the ground boundary condition in the time domain [Salomons et al., Acta Acust. 88, 483-492 (2002)] is to use modified fluid dynamic equations, where the ground is considered as a porous medium described by its physical properties. However, this approach significantly increases computation time, as the domain must be extended into the ground and a large number of grid points are needed. Standard impedance models for the ground boundary condition are frequency-domain models, which generally are non-causal [Y. H. Berthelot, J. Acoust. Soc. Am. 109, 1736-1739 (2001)]. The development of a time-domain boundary condition from these models requires removing the singularity from the impedance equation when transforming from the frequency domain to the time domain. Alternatively, as the impedance boundary condition is a flux equation, a time-domain boundary condition can be derived from first principles, using the physical properties of the ground. We report on our development of a time-domain ground boundary condition.

  18. Direct observation of interlocked domain walls and topological four-state vortex-like domain patterns in multiferroic YMnO{sub 3} single crystal

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Lei [Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, P.O. Box 603, Beijing 100190 (China); School of Materials Science and Engineering, Dalian Jiaotong University, Dalian, Liaoning 116028 (China); Wang, Yumei, E-mail: wangym@iphy.ac.cn; Ge, Binghui; Zhang, Xiangqun [Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, P.O. Box 603, Beijing 100190 (China); Zhang, Zhihua [School of Materials Science and Engineering, Dalian Jiaotong University, Dalian, Liaoning 116028 (China)

    2015-03-16

    Using the advanced spherical aberration-corrected high angle annular dark field scanning transmission electron microscope imaging techniques, we investigated atomic-scale structural features of domain walls and domain patterns in YMnO{sub 3} single crystal. Three different types of interlocked ferroelectric-antiphase domain walls and two abnormal topological four-state vortex-like domain patterns are identified. Each ferroelectric domain wall is accompanied by a translation vector, i.e., 1/6[210] or −1/6[210], demonstrating its interlocked nature. Different from the four-state vortex domain patterns caused by a partial edge dislocation, two four-state vortex-like domain configurations have been obtained at atomic level. These observed phenomena can further extend our understanding of the fascinating vortex domain patterns in multiferroic hexagonal rare-earth manganites.

  19. Bifurcations of Baker domains

    Science.gov (United States)

    Lauber, Arnd

    2007-07-01

    We consider the family of transcendental entire functions given by \\{f_c:{\\mathbb C} \\rightarrow {\\mathbb C}:z-c+e^z, c \\in {\\mathbb C} \\} . If Re c > 0, then fc features a Baker domain as the only component of the Fatou set, while the functions fc show a different dynamical behaviour if c \\in \\rmi{\\mathbb R} . We describe the dynamical planes of these functions and show that the Julia sets converge in the limit process f_{c_1+\\rmi c_2} \\rightarrow f_{\\rmi c_2} with respect to the Hausdorff metric, where c_1 \\in {\\mathbb R}^+ and c_2 \\in {\\mathbb R} . We use this to show that Baker domains of any type (concerning a classification of König) are not necessarily stable under perturbation.

  20. Time Domain Induced Polarization

    DEFF Research Database (Denmark)

    Fiandaca, Gianluca; Auken, Esben; Christiansen, Anders Vest

    2012-01-01

    Time-domain-induced polarization has significantly broadened its field of reference during the last decade, from mineral exploration to environmental geophysics, e.g., for clay and peat identification and landfill characterization. Though, insufficient modeling tools have hitherto limited the use......%. Furthermore, the presence of low-pass filters in time-domain-induced polarization instruments affects the early times of the acquired decays (typically up to 100 ms) and has to be modeled in the forward response to avoid significant loss of resolution. The developed forward code has been implemented in a 1D...... polarization response when compared to traditional integral chargeability inversion. The quality of the inversion results has been assessed by a complete uncertainty analysis of the model parameters; furthermore, borehole information confirm the outcomes of the field interpretations. With this new accurate...

  1. Extended memory management under RTOS

    Science.gov (United States)

    Plummer, M.

    1981-01-01

    A technique for extended memory management in ROLM 1666 computers using FORTRAN is presented. A general software system is described for which the technique can be ideally applied. The memory manager interface with the system is described. The protocols by which the manager is invoked are presented, as well as the methods used by the manager.

  2. Extended time-interval analysis

    DEFF Research Database (Denmark)

    Fynbo, Hans Otto Uldall; Riisager, Karsten

    2014-01-01

    Several extensions of the halflife analysis method recently suggested by Horvat and Hardy are put forward. Goodness-of-fit testing is included, and the method is extended to cases where more information is available for each decay event which allows applications also for e.g. γ decay data. The re...

  3. Extended duration orbiter (EDO) insignia

    Science.gov (United States)

    1990-01-01

    Extended duration orbiter (EDO) insignia incorporates a space shuttle orbiter with payload bay doors (PLBDs) open and a spacelab module inside. Trailing the orbiter are the initials EDO. The EDO-modified Columbia, Orbiter Vehicle (OV) 102, will be flown for the first EDO mission, STS-50.

  4. Extended Duration Orbiter Medical Project

    Science.gov (United States)

    Leach, C. S.; Pool, S. L.; Sawin, C. F.; Nicogossian, A. E.

    1990-01-01

    The Extended Duration Orbiter (EDO) program addresses a need for more time to perform experiments and other tasks during Space Shuttle missions. As a part of this program, the Extended Duration Orbiter Medical Project (EDOMP) has been instituted to obtain information about physiologic effects of extending mission duration and the effectiveness of countermeasures against factors that might compromise crew health, safety, or performance on extended-duration missions. Only those investigations that address and characterize operational problems, develop countermeasures, or evaluate the effectiveness of countermeasures will be pursued. The EDOMP investigations will include flight-associated Detailed Supplementary Objectives as well as ground-based studies simulating the influence of microgravity. Investigator teams have been formed in the following areas: biomedical physiology, cardiovascular and fluid/electrolyte physiology, environmental health, muscle and exercise physiology, and neurophysiology. Major operational questions must be answered in each of these areas, and investigations have been designed to answer them. The EDO program will proceed only after countermeasures have been shown to be effective in preventing or mitigating the adverse changes they have been designed to attenuate. The program is underway and will continue on each Shuttle flight as the manifest builds toward a 16-day orbital flight.

  5. Applying and extending Oracle Spatial

    CERN Document Server

    Simon Gerard Greener, Siva Ravada

    2013-01-01

    This book is an advanced practical guide to applying and extending Oracle Spatial.This book is for existing users of Oracle and Oracle Spatial who have, at a minimum, basic operational experience of using Oracle or an equivalent database. Advanced skills are not required.

  6. Ultrabroadband THz time-domain spectroscopy of biomolecular crystals

    DEFF Research Database (Denmark)

    Kaltenecker, Korbinian J.; Engelbrecht, Sebastian; Iwaszczuk, Krzysztof

    2016-01-01

    Ultrabroadband THz time-domain spectroscopy based on two-color plasma generation and air biased coherent detection is used for the investigation of molecular dynamics of crystalline materials in the frequency range from 0.3 THz to 20 THz. We show that the spectral features in this extended freque...

  7. Método simplificado para el diagnóstico del síndrome de apnea-hipopnea del sueño (SAHS: A propósito de una serie de casos empleando el polígrafo respiratorio BREAS SC-20.

    Directory of Open Access Journals (Sweden)

    Jorge Rey de Castro Mujica

    2007-04-01

    Full Text Available Objetivo: Presentar una serie de casos con diagnóstico de síndrome apnea hipopnea del Sueño (SAHS establecido con un polígrafo respiratorio (PR. Materiales y métodos: Se presentan 53 PRs realizadas entre enero 2005 y octubre 2006 en pacientes con sospecha de trastornos respiratorios del sueño. Se utilizó el polígrafo respiratorio BREAS SC-20 validado por nosotros anteriormente. La prueba fue implementada a lo largo de la noche en el domicilio del paciente y sin supervisión de personal técnico. En 32 (60% casos la PR fue instalada en el consultorio y el resto en el domicilio del paciente. Resultados: Se analizaron 53 PRs, realizadas en el mismo número de pacientes. El equipo falló en seis (11% ocasiones; las seis pruebas fueron repetidas obteniéndose buenos resultados para el análisis. El Tiempo de registro fue 7,7±1,1 [5,5-10,7] horas, índice de apnea-hipopnea 35,5±20 [0-82], tiempo porcentual de registro con SatO2Hb menor de 90% (T90 9,8±15,2 [0-62] % y desaturación máxima de oxígeno (DesMax 73±14,8 [38-91] %. Los principales diagnósticos fueron: SAHS 46 (86%, apnea central con patrón periódico Cheyne Stokes 3 (6%, ronquido primario benigno 2 (4% y prueba normal 2 (4%. El procedimiento fue bien tolerado y no hubo efectos secundarios relacionados. Conclusiones: Con los resultados obtenidos, consideramos que el sistema BREAS SC-20 bajo supervisión de médicos entrenados en los trastornos respiratorios del sueño; es una herramienta útil, práctica y económica para el diagnóstico del SAHS.(Rev Med Hered 2007;18:59-67.

  8. Evaluate extended surface exchangers carefully

    Energy Technology Data Exchange (ETDEWEB)

    Ganapathy, V. (ABCO Industries, Inc., Abilene, TX (US))

    1990-10-01

    Various types of fins, such as circumferential, rectangular, pegs and rods are used in heat transfer equipment. Fins can be used inside as well as on the outside of tubes. However, to illustrate the basic facts of heat transfer and how one should evaluate fins, these discussions pertain to circumferential solid or serrated fins used widely in the energy equipment industry. Extended surfaces have the advantage of reducing the size and weight of heat transfer equipment. In addition they can result in lower gas pressure drop, thus reducing the operating costs. This article compares the performance of an evaporator for a heat recovery steam generator (HRSG) using bare and finned tubes. The fact this article brings out is that extended surfaces should be evaluated and purchased based on performance and not based on surface area alone.

  9. Extended Supersymmetries in One Dimension

    Directory of Open Access Journals (Sweden)

    F. Toppan

    2008-01-01

    Full Text Available This work covers part of the material presented at the Advanced Summer School in Prague. It is mostly devoted to the structural properties of Extended Supersymmetries in One Dimension. Several results are presented on the classification of linear, irreducible representations realized on a finite number of time-dependent fields. The connections between supersymmetry transformations, Clifford algebras and division algebras are discussed. A manifestly supersymmetric framework for constructing invariants without using the notion of superfields is presented. A few examples of one-dimensional, N-extended, off-shell invariant sigma models are computed. The relation between supersymmetry transformations and graph theory is outlined. The notion of the fusion algebra of irreps tensor products is presented. The relevance of one-dimensional Supersymmetric Quantum Mechanics as a way to extract information on higher dimensional supersymmetric field theories is discussed. 

  10. Partial domain wall partition functions

    National Research Council Canada - National Science Library

    Foda, O; Wheeler, M

    2012-01-01

    We consider six-vertex model configurations on an (n × N) lattice, n ≤ N, that satisfy a variation on domain wall boundary conditions that we define and call partial domain wall boundary conditions...

  11. Extending a browser C++ simulator

    OpenAIRE

    Segarra Roca, Albert

    2017-01-01

    Getting started in computer programming involves using a number of tools such as editors, compilers, debuggers, and terminals. Learning how to use them can be challenging for programming begginers, and installing them may be demanding for certain organizations such as high schools. C– is a project that aims to bridge this gap by providing an educational C++ development environment that runs in a web browser. The goal of this thesis is to extend and improve the current implement...

  12. Locating and extending livelihoods research

    DEFF Research Database (Denmark)

    Prowse, Martin

    2008-01-01

    Much poverty and development research is not explicit about its methodology or philosophical foundations. Based on the extended case method of Burawoy and the epistemological standpoint of critical realism, this paper discusses a methodological approach for reflexive inductive livelihoods research...... that overcomes the unproductive social science dualism of positivism and social constructivism. The approach is linked to a conceptual framework and a menu of research methods that can be sequenced and iterated in light of research questions....

  13. Evolving extended naive Bayes classifiers

    OpenAIRE

    Klawonn, Frank; Angelov, Plamen

    2006-01-01

    Naive Bayes classifiers are a very simple, but often effective tool for classification problems, although they are based on independence assumptions that do not hold in most cases. Extended naive Bayes classifiers also rely on independence assumptions, but break them down to artificial subclasses, in this way becoming more powerful than ordinary naive Bayes classifiers. Since the involved computations for Bayes classifiers are basically generalised mean value calculations, they easily render ...

  14. A sampling theorem on shift-invariant spaces associated with the fractional Fourier transform domain

    OpenAIRE

    Kang, Sinuk

    2013-01-01

    As a generalization of the Fourier transform, the fractional Fourier transform was introduced and has been further investigated both in theory and in applications of signal processing. We obtain a sampling theorem on shift-invariant spaces associated with the fractional Fourier transform domain. The resulting sampling theorem extends not only the classical Whittaker-Shannon-Kotelnikov sampling theorem associated with the fractional Fourier transform domain, but also extends the prior sampling...

  15. Domain walls on the brane

    NARCIS (Netherlands)

    Bergshoeff, E; van der Schaar, JP; Papadopoulos, G

    1998-01-01

    We show that all branes admit worldvolume domain wall solutions. We find one class of solutions for which the tension of the brane changes discontinuously along the domain wall. These solutions are not supersymmetric. We argue that there is another class of domain wall solutions which is

  16. Feature-level domain adaptation

    DEFF Research Database (Denmark)

    Kouw, Wouter M.; Van Der Maaten, Laurens J P; Krijthe, Jesse H.

    2016-01-01

    Domain adaptation is the supervised learning setting in which the training and test data are sampled from different distributions: training data is sampled from a source domain, whilst test data is sampled from a target domain. This paper proposes and studies an approach, called feature...

  17. Module theory, extending modules and generalizations

    CERN Document Server

    Tercan, Adnan

    2016-01-01

    The main focus of this monograph is to offer a comprehensive presentation of known and new results on various generalizations of CS-modules and CS-rings. Extending (or CS) modules are generalizations of injective (and also semisimple or uniform) modules. While the theory of CS-modules is well documented in monographs and textbooks, results on generalized forms of the CS property as well as dual notions are far less present in the literature. With their work the authors provide a solid background to module theory, accessible to anyone familiar with basic abstract algebra. The focus of the book is on direct sums of CS-modules and classes of modules related to CS-modules, such as relative (injective) ejective modules, (quasi) continuous modules, and lifting modules. In particular, matrix CS-rings are studied and clear proofs of fundamental decomposition results on CS-modules over commutative domains are given, thus complementing existing monographs in this area. Open problems round out the work and establish the...

  18. Metaphors, domains and embodiment

    Directory of Open Access Journals (Sweden)

    M.E. Botha

    2005-07-01

    Full Text Available Investigations of metaphorical meaning constitution and meaning (in- variance have revealed the significance of semantic and semiotic domains and the contexts within which they function as basis for the grounding of metaphorical meaning. In this article some of the current views concerning the grounding of metaphorical meaning in experience and embodiment are explored. My provisional agreement with Lakoff, Johnson and others about the “conceptual” nature of metaphor rests on an important caveat, viz. that this bodily based conceptual structure which lies at the basis of linguistic articulations of metaphor, is grounded in a deeper ontic structure of the world and of human experience. It is the “metaphorical” (actually “analogical” ontological structure of this grounding that is of interest for the line of argumentation followed in this article. Because Johnson, Lakoff and other’s proposal to ground metaphorical meaning in embodiment and neural processes is open to being construed as subjectivist and materialist, I shall attempt to articulate the contours of an alternative theory of conceptual metaphor, meaning and embodiment which counteracts these possibilities. This theory grounds metaphorical meaning and meaning change in an ontological and anthropological framework which recognises the presence and conditioning functioning of radially ordered structures for reality. These categorisations in which humankind, human knowledge and reality participate, condition and constrain (ground analogical and metaphorical meaning transfer, cross-domain mappings, and blends in cognition and in language, provide the basis for the analogical concepts found in these disciplines.

  19. On Probability Domains IV

    Science.gov (United States)

    Frič, Roman; Papčo, Martin

    2017-12-01

    Stressing a categorical approach, we continue our study of fuzzified domains of probability, in which classical random events are replaced by measurable fuzzy random events. In operational probability theory (S. Bugajski) classical random variables are replaced by statistical maps (generalized distribution maps induced by random variables) and in fuzzy probability theory (S. Gudder) the central role is played by observables (maps between probability domains). We show that to each of the two generalized probability theories there corresponds a suitable category and the two resulting categories are dually equivalent. Statistical maps and observables become morphisms. A statistical map can send a degenerated (pure) state to a non-degenerated one —a quantum phenomenon and, dually, an observable can map a crisp random event to a genuine fuzzy random event —a fuzzy phenomenon. The dual equivalence means that the operational probability theory and the fuzzy probability theory coincide and the resulting generalized probability theory has two dual aspects: quantum and fuzzy. We close with some notes on products and coproducts in the dual categories.

  20. On Probability Domains IV

    Science.gov (United States)

    Frič, Roman; Papčo, Martin

    2017-06-01

    Stressing a categorical approach, we continue our study of fuzzified domains of probability, in which classical random events are replaced by measurable fuzzy random events. In operational probability theory (S. Bugajski) classical random variables are replaced by statistical maps (generalized distribution maps induced by random variables) and in fuzzy probability theory (S. Gudder) the central role is played by observables (maps between probability domains). We show that to each of the two generalized probability theories there corresponds a suitable category and the two resulting categories are dually equivalent. Statistical maps and observables become morphisms. A statistical map can send a degenerated (pure) state to a non-degenerated one —a quantum phenomenon and, dually, an observable can map a crisp random event to a genuine fuzzy random event —a fuzzy phenomenon. The dual equivalence means that the operational probability theory and the fuzzy probability theory coincide and the resulting generalized probability theory has two dual aspects: quantum and fuzzy. We close with some notes on products and coproducts in the dual categories.

  1. Expansion of protein domain repeats.

    Directory of Open Access Journals (Sweden)

    Asa K Björklund

    2006-08-01

    Full Text Available Many proteins, especially in eukaryotes, contain tandem repeats of several domains from the same family. These repeats have a variety of binding properties and are involved in protein-protein interactions as well as binding to other ligands such as DNA and RNA. The rapid expansion of protein domain repeats is assumed to have evolved through internal tandem duplications. However, the exact mechanisms behind these tandem duplications are not well-understood. Here, we have studied the evolution, function, protein structure, gene structure, and phylogenetic distribution of domain repeats. For this purpose we have assigned Pfam-A domain families to 24 proteomes with more sensitive domain assignments in the repeat regions. These assignments confirmed previous findings that eukaryotes, and in particular vertebrates, contain a much higher fraction of proteins with repeats compared with prokaryotes. The internal sequence similarity in each protein revealed that the domain repeats are often expanded through duplications of several domains at a time, while the duplication of one domain is less common. Many of the repeats appear to have been duplicated in the middle of the repeat region. This is in strong contrast to the evolution of other proteins that mainly works through additions of single domains at either terminus. Further, we found that some domain families show distinct duplication patterns, e.g., nebulin domains have mainly been expanded with a unit of seven domains at a time, while duplications of other domain families involve varying numbers of domains. Finally, no common mechanism for the expansion of all repeats could be detected. We found that the duplication patterns show no dependence on the size of the domains. Further, repeat expansion in some families can possibly be explained by shuffling of exons. However, exon shuffling could not have created all repeats.

  2. Ligand binding by PDZ domains

    DEFF Research Database (Denmark)

    Chi, Celestine N.; Bach, Anders; Strømgaard, Kristian

    2012-01-01

    The postsynaptic density protein-95/disks large/zonula occludens-1 (PDZ) protein domain family is one of the most common protein-protein interaction modules in mammalian cells, with paralogs present in several hundred human proteins. PDZ domains are found in most cell types, but neuronal proteins......, for example, are particularly rich in these domains. The general function of PDZ domains is to bring proteins together within the appropriate cellular compartment, thereby facilitating scaffolding, signaling, and trafficking events. The many functions of PDZ domains under normal physiological as well...

  3. A difference-equation formalism for the nodal domains of separable billiards

    Energy Technology Data Exchange (ETDEWEB)

    Manjunath, Naren; Samajdar, Rhine [Indian Institute of Science, Bangalore 560012 (India); Jain, Sudhir R., E-mail: srjain@barc.gov.in [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2016-09-15

    Recently, the nodal domain counts of planar, integrable billiards with Dirichlet boundary conditions were shown to satisfy certain difference equations in Samajdar and Jain (2014). The exact solutions of these equations give the number of domains explicitly. For complete generality, we demonstrate this novel formulation for three additional separable systems and thus extend the statement to all integrable billiards.

  4. Departies: conceptualizing extended youth parties

    DEFF Research Database (Denmark)

    Fjær, Eivind Grip; Tutenges, Sébastien

    2017-01-01

    -taking behaviors, such as drug use and violence. Here, we scrutinize the research on extended youth parties to identify general changes that young people undergo at these events. We call these celebrations departies, because they center on the organization and facilitation of momentary departures from...... immoral; (4) stylistically, by altering their stylistic expressions through dress, demeanor, and consumption; and (5) experientially, because the parties generate mood and mind alterations. These are overlapping and intertwined elements, the combination of which amounts to a distinct type of youth party...

  5. Domain wall assisted GMR head with spin-Hall effect

    Science.gov (United States)

    Arun, R.; Sabareesan, P.; Daniel, M.

    2016-05-01

    We theoretically study the dynamics of a field induced domain wall in the Py/Pt bi-layer structure in the presence of spin-Hall effect (SHE) by solving the Landau-Lifshitz-Gilbert (LLG) equation along with the adiabatic, nonadiabatic and SHE spin-transfer torques (STTs). It is observed that a weak magnetic field moves the domain wall with high velocity in the presence of SHE and the direction of the velocity is changed by changing the direction of the weak field. The numerical results show that the magnetization of the ferromagnetic layer can be reversed quickly through domain wall motion by changing the direction of a weak external field in the presence of SHE while the direction of current is fixed. The SHE reduces the magnetization reversal time of 1000 nm length strip by 14.7 ns. This study is extended to model a domain wall based GMR (Giant Magnetoresistance) read head with SHE.

  6. Domain architecture conservation in orthologs.

    Science.gov (United States)

    Forslund, Kristoffer; Pekkari, Isabella; Sonnhammer, Erik L L

    2011-08-05

    As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a protein's function. By domain architecture we refer to the sequential arrangement of domains along a protein sequence.To assess the level of domain architecture conservation among orthologs, we carried out a large-scale study of such events between human and 40 other species spanning the entire evolutionary range. We designed a score to measure domain architecture similarity and used it to analyze differences in domain architecture conservation between orthologs and paralogs relative to the conservation of primary sequence. We also statistically characterized the extents of different types of domain swapping events across pairs of orthologs and paralogs. The analysis shows that orthologs exhibit greater domain architecture conservation than paralogous homologs, even when differences in average sequence divergence are compensated for, for homologs that have diverged beyond a certain threshold. We interpret this as an indication of a stronger selective pressure on orthologs than paralogs to retain the domain architecture required for the proteins to perform a specific function. In general, orthologs as well as the closest paralogous homologs have very similar domain architectures, even at large evolutionary separation.The most common domain architecture changes observed in both ortholog and paralog pairs involved insertion/deletion of new domains, while domain shuffling and segment duplication/deletion were very infrequent. On the whole, our results support the hypothesis that function conservation between orthologs demands higher domain architecture conservation than other types of homologs, relative to primary sequence conservation. This supports the notion that orthologs are

  7. Domain architecture conservation in orthologs

    Science.gov (United States)

    2011-01-01

    Background As orthologous proteins are expected to retain function more often than other homologs, they are often used for functional annotation transfer between species. However, ortholog identification methods do not take into account changes in domain architecture, which are likely to modify a protein's function. By domain architecture we refer to the sequential arrangement of domains along a protein sequence. To assess the level of domain architecture conservation among orthologs, we carried out a large-scale study of such events between human and 40 other species spanning the entire evolutionary range. We designed a score to measure domain architecture similarity and used it to analyze differences in domain architecture conservation between orthologs and paralogs relative to the conservation of primary sequence. We also statistically characterized the extents of different types of domain swapping events across pairs of orthologs and paralogs. Results The analysis shows that orthologs exhibit greater domain architecture conservation than paralogous homologs, even when differences in average sequence divergence are compensated for, for homologs that have diverged beyond a certain threshold. We interpret this as an indication of a stronger selective pressure on orthologs than paralogs to retain the domain architecture required for the proteins to perform a specific function. In general, orthologs as well as the closest paralogous homologs have very similar domain architectures, even at large evolutionary separation. The most common domain architecture changes observed in both ortholog and paralog pairs involved insertion/deletion of new domains, while domain shuffling and segment duplication/deletion were very infrequent. Conclusions On the whole, our results support the hypothesis that function conservation between orthologs demands higher domain architecture conservation than other types of homologs, relative to primary sequence conservation. This supports the

  8. Protein domain organisation: adding order

    Directory of Open Access Journals (Sweden)

    Kummerfeld Sarah K

    2009-01-01

    Full Text Available Abstract Background Domains are the building blocks of proteins. During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions. Structural and genome-scale studies have shown that pairs or groups of domains observed together in a protein are almost always found in only one N to C terminal order and are the result of a single recombination event that has been propagated by duplication of the multi-domain unit. Previous studies of domain organisation have used graph theory to represent the co-occurrence of domains within proteins. We build on this approach by adding directionality to the graphs and connecting nodes based on their relative order in the protein. Most of the time, the linear order of domains is conserved. However, using the directed graph representation we have identified non-linear features of domain organization that are over-represented in genomes. Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved. Results We identify groups of domains that are not linearly conserved, but instead have been shuffled during evolution so that they occur in multiple different orders. We consider 192 genomes across all three kingdoms of life and use domain and protein annotation to understand their functional significance. To identify these features and assess their statistical significance, we represent the linear order of domains in proteins as a directed graph and apply graph theoretical methods. We describe two higher-order patterns of domain organisation: clusters and bi-directionally associated domain pairs and explore their functional importance and phylogenetic conservation. Conclusion Taking into account the order of domains, we have derived a novel picture of global protein organization. We found that all genomes have a higher than expected

  9. The Garrison Domain: Civil Military Relations in the Cyberspace Domain

    Science.gov (United States)

    2015-04-01

    governance, commerce , communications, and entertainment. The reliance on cyberspace is so predominant it seems unacceptable to not be part of the domain...Almost every type of person and organization on this planet arguably touches the cyberspace domain, directly or indirectly. Because this domain is...Department of Justice (DOJ) has also begun using cyberspace to gather information intelligence. Flying small civilian aircraft with electronic boxes to

  10. A Social Contract Account for CSR as Extended Model of Corporate Governance (Part I): Rational Bargaining and Justification

    OpenAIRE

    Lorenzo Sacconi

    2004-01-01

    This paper is the first part of a two parts essay aimed at giving a contractarian foundation to the concept of Corporate Social Responsibility (CSR) meant as an extended model of corporate governance of the firm. I fist present the heuristics of the scientific program meant to theorizing over an institution like a system of corporate governance, which is partitioned in two domains, the justification domain and the compliance domain. Bargaining theory, reputation game and reciprocity theories,...

  11. Numerical Solution of Riccati Equations by the Adomian and Asymptotic Decomposition Methods over Extended Domains

    Directory of Open Access Journals (Sweden)

    Jafar Biazar

    2015-01-01

    Full Text Available We combine the Adomian decomposition method (ADM and Adomian’s asymptotic decomposition method (AADM for solving Riccati equations. We investigate the approximate global solution by matching the near-field approximation derived from the Adomian decomposition method with the far-field approximation derived from Adomian’s asymptotic decomposition method for Riccati equations and in such cases when we do not find any region of overlap between the obtained approximate solutions by the two proposed methods, we connect the two approximations by the Padé approximant of the near-field approximation. We illustrate the efficiency of the technique for several specific examples of the Riccati equation for which the exact solution is known in advance.

  12. Skierarchy: Extending the Power of Crowdsourcing Using a Hierarchy of Domain Experts, Crowd and Machine Learning

    Science.gov (United States)

    2012-11-01

    art to art- lovers . 5 www.lexmachina.com creates a structured knowledge base from unstructured legal dockets. 6 www.esparklearning.com recommends...For IRAT, we used the same crowd that we used for TRAT, but significantly enhanced the workflow and UI to adapt to the requirements of IRAT. In...quality. In addition to micro tasking and qualification, skill enhancement of crowd through training, expert coaching/feedback and appropriate

  13. Topics in Extended Dynamical Systems

    Science.gov (United States)

    Bhagavatula, Ravi S.

    This thesis consists of three chapters. Each chapter is self-contained and is devoted to the investigation of a particular topic in extended dynamical systems. In the first chapter, an approach based on Langevin equations is implemented to understand the non-Gaussian nature of the probability distribution function (PDF) of local diffusive variables in extended dynamical systems, e.g., a passive scalar advected by turbulent velocity fluctuations. Two mechanisms are proposed for the origin of non-Gaussian tails: One relies on the nature of temporal correlations of the fluctuations that couple additively to the diffusive field, leading to exponential and stretched exponential tails in the PDF; the other depends on multiplicative coupling between the diffusive field and the fluctuations, producing algebraic tails in the PDF. The mechanisms are illustrated using models for a passive scalar and also a current driven Josephson junction array. This study indicates that shapes of local PDFs in turbulent states are non-universal and crucially depend on local couplings and time scales. The second chapter establishes the existence of a class of locally conserving chaotic (deterministic) systems that exhibit Generic Scale Invariance--algebraic decay of spatial and temporal correlations without tuning parameters. This study also reveals the similarity between noise and chaos in extended systems as far as long-wavelength and long -time behavior is concerned. Specifically, a two dimensional coupled-map lattice model with a conserved density is numerically shown to exhibit, in agreement with heuristic arguments, algebraic decay of spatio-temporal correlations in chaotic states with simple predictable exponents. The third chapter investigates scaling behavior of earthquakes in seismic zone models in which an earthquake is modeled by a quasi-static description that ignores short -time dynamics during an earthquake. The models incorporate the essential feature of long-ranged stress

  14. Magnetic imaging by x-ray holography using extended references

    Science.gov (United States)

    Duckworth, Thomas A.; Ogrin, Feodor; Dhesi, Sarnjeet S.; Langridge, Sean; Whiteside, Amy; Moore, Thomas; Beutier, Guillaume; van der Laan, Gerrit

    2011-08-01

    We demonstrate magnetic lensless imaging by Fourier transform holography using extended references. A narrow slit milled through an opaque gold mask is used as a holographic reference and magnetic contrast is obtained by x-ray magnetic circular dichroism. We present images of magnetic domains in a Co/Pt multilayer thin film with perpendicular magnetic anisotropy. This technique holds advantages over standard Fourier transform holography, where small holes are used to define the reference beam. An increased intensity through the extended reference reduces the counting time to record the farfield diffraction pattern. Additionally it was found that manufacturing narrow slits is less technologically demanding than the same procedure for holes. We achieve a spatial resolution of ˜30 nm, which was found to be limited by the sample period of the chosen experimental setup.

  15. The extended growth of graphene oxide flakes using ethanol CVD.

    Science.gov (United States)

    Huang, Jingfeng; Larisika, Melanie; Fam, W H Derrick; He, Qiyuan; Nimmo, Myra A; Nowak, Christoph; Tok, I Y Alfred

    2013-04-07

    We report the extended growth of Graphene Oxide (GO) flakes using atmospheric pressure ethanol Chemical Vapor Deposition (CVD). GO was used to catalyze the deposition of carbon on a substrate in the ethanol CVD with Ar and H2 as carrier gases. Raman, SEM, XPS and AFM characterized the growth to be a reduced GO (RGO) of layers. This newly grown RGO possesses lower defect density with larger and increased distribution of sp(2) domains than chemically reduced RGO. Furthermore this method without optimization reduces the relative standard deviation of electrical conductivity between chips, from 80.5% to 16.5%, enabling RGO to be used in practical electronic devices.

  16. Extended uncertainty from first principles

    Energy Technology Data Exchange (ETDEWEB)

    Costa Filho, Raimundo N., E-mail: rai@fisica.ufc.br [Departamento de Física, Universidade Federal do Ceará, Caixa Postal 6030, Campus do Pici, 60455-760 Fortaleza, Ceará (Brazil); Braga, João P.M., E-mail: philipe@fisica.ufc.br [Instituto de Ciências Exatas e da Natureza-ICEN, Universidade da Integração Internacional da Lusofonia Afro-Brasileira-UNILAB, Campus dos Palmares, 62785-000 Acarape, Ceará (Brazil); Lira, Jorge H.S., E-mail: jorge.lira@mat.ufc.br [Departamento de Matemática, Universidade Federal do Ceará, Caixa Postal 6030, Campus do Pici, 60455-760 Fortaleza, Ceará (Brazil); Andrade, José S., E-mail: soares@fisica.ufc.br [Departamento de Física, Universidade Federal do Ceará, Caixa Postal 6030, Campus do Pici, 60455-760 Fortaleza, Ceará (Brazil)

    2016-04-10

    A translation operator acting in a space with a diagonal metric is introduced to describe the motion of a particle in a quantum system. We show that the momentum operator and, as a consequence, the uncertainty relation now depend on the metric. It is also shown that, for any metric expanded up to second order, this formalism naturally leads to an extended uncertainty principle (EUP) with a minimum momentum dispersion. The Ehrenfest theorem is modified to include an additional term related to a tidal force arriving from the space curvature introduced by the metric. For one-dimensional systems, we show how to map a harmonic potential to an effective potential in Euclidean space using different metrics.

  17. Center for Extended Magnetohydrodynamics Modeling

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Jesus [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

    2017-02-14

    This researcher participated in the DOE-funded Center for Extended Magnetohydrodynamics Modeling (CEMM), a multi-institutional collaboration led by the Princeton Plasma Physics Laboratory with Dr. Stephen Jardin as the overall Principal Investigator. This project developed advanced simulation tools to study the non-linear macroscopic dynamics of magnetically confined plasmas. The collaborative effort focused on the development of two large numerical simulation codes, M3D-C1 and NIMROD, and their application to a wide variety of problems. Dr. Ramos was responsible for theoretical aspects of the project, deriving consistent sets of model equations applicable to weakly collisional plasmas and devising test problems for verification of the numerical codes. This activity was funded for twelve years.

  18. Hamiltonian dynamics of extended objects

    Energy Technology Data Exchange (ETDEWEB)

    Capovilla, R [Departamento de FIsica, Centro de Investigacion y de Estudios Avanzados del IPN, Apdo Postal 14-740, 07000 Mexico, DF (Mexico); Guven, J [School of Theoretical Physics, Dublin Institute for Advanced Studies, 10 Burlington Road, Dublin 4 (Ireland); Rojas, E [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Apdo Postal 70-543, 04510 Mexico, DF (Mexico)

    2004-12-07

    We consider relativistic extended objects described by a reparametrization-invariant local action that depends on the extrinsic curvature of the worldvolume swept out by the object as it evolves. We provide a Hamiltonian formulation of the dynamics of such higher derivative models which is motivated by the ADM formulation of general relativity. The canonical momenta are identified by looking at boundary behaviour under small deformations of the action; the relationship between the momentum conjugate to the embedding functions and the conserved momentum density is established. The canonical Hamiltonian is constructed explicitly; the constraints on the phase space, both primary and secondary, are identified and the role they play in the theory is described. The multipliers implementing the primary constraints are identified in terms of the ADM lapse and shift variables and Hamilton's equations are shown to be consistent with the Euler-Lagrange equations.

  19. Extended mission life support systems

    Science.gov (United States)

    Quattrone, P. D.

    1985-01-01

    Extended manned space missions which include interplanetary missions require regenerative life support systems. Manned mission life support considerations are placed in perspective and previous manned space life support system technology, activities and accomplishments in current supporting research and technology (SR&T) programs are reviewed. The life support subsystem/system technologies required for an enhanced duration orbiter (EDO) and a space operations center (SOC), regenerative life support functions and technology required for manned interplanetary flight vehicles, and future development requirements are outlined. The Space Shuttle Orbiters (space transportation system) is space cabin atmosphere is maintained at Earth ambient pressure of 14.7 psia (20% O2 and 80% N2). The early Shuttle flights will be seven-day flights, and the life support system flight hardware will still utilize expendables.

  20. Extended Fundamental Model of Resonance

    Science.gov (United States)

    Breiter, Sławomir

    2003-03-01

    Fundamental models are the simplest, one degree of freedom Hamiltonians that serve as a tool to understand the qualitative effects of various resonances. A new, extended fundamental model (EFM) is proposed in order to improve the classical, Andoyer type, second fundamental model (SFM). The EFM Hamiltonian differs from the SFM by the addition of a term with the third power of momentum; it depends on two free parameters. The new model is studied for the case of a first-order resonance, where up to five critical points can be present. Similarly, to the respective SFM, it admits only the saddle-node bifurcations of critical points, but its advantage lies in the capability of generating the separatrix bifurcations, known also as saddle connections. The reduction of parameters for the EFM has been performed in a way that allows the use of the model in the case of the so-called abnormal resonance.

  1. Learning Extended Finite State Machines

    Science.gov (United States)

    Cassel, Sofia; Howar, Falk; Jonsson, Bengt; Steffen, Bernhard

    2014-01-01

    We present an active learning algorithm for inferring extended finite state machines (EFSM)s, combining data flow and control behavior. Key to our learning technique is a novel learning model based on so-called tree queries. The learning algorithm uses the tree queries to infer symbolic data constraints on parameters, e.g., sequence numbers, time stamps, identifiers, or even simple arithmetic. We describe sufficient conditions for the properties that the symbolic constraints provided by a tree query in general must have to be usable in our learning model. We have evaluated our algorithm in a black-box scenario, where tree queries are realized through (black-box) testing. Our case studies include connection establishment in TCP and a priority queue from the Java Class Library.

  2. Catalytic distillation extends its reach

    Energy Technology Data Exchange (ETDEWEB)

    Rock, K.; McGuirk, T. [Catalytic Distillation Technologies, Houston, TX (United States); Gildert, G.R. [Catalytic Distillation Technologies, Pasadena, TX (United States)

    1997-07-01

    Since the early 1980s, catalytic distillation processes have been selected by more than a hundred operators for various applications. Since such a unit performs both reaction and distillation simultaneously, a combined column can replace a separate, fixed-bed reactor and distillation column, thereby eliminating equipment and reducing capital costs. And, compared to the conventional approach, catalytic distillation may also improve other factors, such as reactant conversion, selectivity, mass transfer, operating pressure, oligomer formation and catalyst fouling. The constant washing of the catalyst by liquid flowing down the column and the distillation of high-boiling foulants results in extended catalyst life. Four selective hydrogenation applications of catalytic distillation are discussed: Butadiene selective hydrogenation combined within an MTBE unit; Pentadiene selective hydrogenation; C{sub 4} acetylene conversion; and Benzene saturation.

  3. Oral hydromorphone extended-release.

    Science.gov (United States)

    Guay, David R P

    2010-12-01

    To review the chemistry, pharmacodynamics, pharmacokinetics, efficacy, tolerability, dosing, and role of the Osmotic-controlled Release Oral delivery System (OROS) hydromorphone extended-release (ER) tablets. A MEDLINE/PUBMED search (1986-August 2010) was conducted to identify studies in the English language, with additional references being obtained from their bibliographies. All studies of hydromorphone ER were reviewed. This is the second long-acting hydromorphone formulation to receive approval by the Food and Drug Administration (a twice-daily formulation was approved in September 2004, but was subsequently withdrawn in July 2005). Hydromorphone is a semi-synthetic mu-opioid receptor agonist structurally similar to morphine, hydrocodone, and oxymorphone. OROS ER technology allows once-daily dosing. Clinical trials have focused on the convertibility of (an) other opioid(s) to hydromorphone ER in chronic malignant and nonmalignant pain. This product displays the expected opioid side effects, being comparable to oxycodone controlled-release. Coadministration with ethanol does not produce the degree of "dose-dumping" seen with the former hydromorphone twice-daily product or oxymorphone ER. Hydromorphone ER is indicated for the management of moderate-to-severe pain in opioidtolerant patients requiring continuous, around-the-clock opioid analgesia for an extended period of time. Dosage adjustment is recommended in patients with moderate hepatic impairment (Child-Pugh class B) and moderate renal impairment (creatinine clearance of 30-60 mL/min). Hydromorphone ER is the newest oral opioid to enter a crowded marketplace now totaling 15 different Schedule 2 opioids (including tapentadol), and tramadol, available in oral, parenteral, rectal, transdermal, transmucosal, and intranasal formulations. It does not appear to have any unique assets or liabilities and should be considered as one of many oral opioids available for the management of persistent pain of moderate

  4. THE EXTENDED VIRGO CLUSTER CATALOG

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Suk; Rey, Soo-Chang; Lee, Youngdae; Chung, Jiwon; Pak, Mina; Yi, Wonhyeong; Lee, Woong [Department of Astronomy and Space Science, Chungnam National University, 99 Daehak-ro, Daejeon 305-764 (Korea, Republic of); Jerjen, Helmut [Research School of Astronomy and Astrophysics, The Australian National University, Cotter Road, Weston, ACT 2611 (Australia); Lisker, Thorsten [Astronomisches Rechen-Institut, Zentrum für Astronomie der Universität Heidelberg (ZAH), Mönchhofstraße 12-14, D-69120 Heidelberg (Germany); Sung, Eon-Chang [Korea Astronomy and Space Science institute, 776 Daedeokdae-ro, Daejeon 305-348 (Korea, Republic of)

    2015-01-01

    We present a new catalog of galaxies in the wider region of the Virgo cluster, based on the Sloan Digital Sky Survey (SDSS) Data Release 7. The Extended Virgo Cluster Catalog (EVCC) covers an area of 725 deg{sup 2} or 60.1 Mpc{sup 2}. It is 5.2 times larger than the footprint of the classical Virgo Cluster Catalog (VCC) and reaches out to 3.5 times the virial radius of the Virgo cluster. We selected 1324 spectroscopically targeted galaxies with radial velocities less than 3000 km s{sup –1}. In addition, 265 galaxies that have been overlooked in the SDSS spectroscopic survey but have available redshifts in the NASA Extragalactic Database are also included. Our selection process secured a total of 1589 galaxies, 676 of which are not included in the VCC. The certain and possible cluster members are defined by means of redshift comparison with a cluster infall model. We employed two independent and complementary galaxy classification schemes: the traditional morphological classification based on the visual inspection of optical images and a characterization of galaxies from their spectroscopic features. SDSS u, g, r, i, and z passband photometry of all EVCC galaxies was performed using Source Extractor. We compare the EVCC galaxies with the VCC in terms of morphology, spatial distribution, and luminosity function. The EVCC defines a comprehensive galaxy sample covering a wider range in galaxy density that is significantly different from the inner region of the Virgo cluster. It will be the foundation for forthcoming galaxy evolution studies in the extended Virgo cluster region, complementing ongoing and planned Virgo cluster surveys at various wavelengths.

  5. Mapping the Moral Domain

    Science.gov (United States)

    Graham, Jesse; Nosek, Brian A.; Haidt, Jonathan; Iyer, Ravi; Koleva, Spassena; Ditto, Peter H.

    2010-01-01

    The moral domain is broader than the empathy and justice concerns assessed by existing measures of moral competence, and it is not just a subset of the values assessed by value inventories. To fill the need for reliable and theoretically-grounded measurement of the full range of moral concerns, we developed the Moral Foundations Questionnaire (MFQ) based on a theoretical model of five universally available (but variably developed) sets of moral intuitions: Harm/care, Fairness/reciprocity, Ingroup/loyalty, Authority/respect, and Purity/sanctity. We present evidence for the internal and external validity of the scale and the model, and in doing so present new findings about morality: 1. Comparative model fitting of confirmatory factor analyses provides empirical justification for a five-factor structure of moral concerns. 2. Convergent/discriminant validity evidence suggests that moral concerns predict personality features and social group attitudes not previously considered morally relevant. 3. We establish pragmatic validity of the measure in providing new knowledge and research opportunities concerning demographic and cultural differences in moral intuitions. These analyses provide evidence for the usefulness of Moral Foundations Theory in simultaneously increasing the scope and sharpening the resolution of psychological views of morality. PMID:21244182

  6. Time-Extended Policies in Mult-Agent Reinforcement Learning

    Science.gov (United States)

    Tumer, Kagan; Agogino, Adrian K.

    2004-01-01

    Reinforcement learning methods perform well in many domains where a single agent needs to take a sequence of actions to perform a task. These methods use sequences of single-time-step rewards to create a policy that tries to maximize a time-extended utility, which is a (possibly discounted) sum of these rewards. In this paper we build on our previous work showing how these methods can be extended to a multi-agent environment where each agent creates its own policy that works towards maximizing a time-extended global utility over all agents actions. We show improved methods for creating time-extended utilities for the agents that are both "aligned" with the global utility and "learnable." We then show how to crate single-time-step rewards while avoiding the pi fall of having rewards aligned with the global reward leading to utilities not aligned with the global utility. Finally, we apply these reward functions to the multi-agent Gridworld problem. We explicitly quantify a utility's learnability and alignment, and show that reinforcement learning agents using the prescribed reward functions successfully tradeoff learnability and alignment. As a result they outperform both global (e.g., team games ) and local (e.g., "perfectly learnable" ) reinforcement learning solutions by as much as an order of magnitude.

  7. Domain imaging in FINEMET ribbons

    Energy Technology Data Exchange (ETDEWEB)

    Silveyra, J.M., E-mail: jsilveyra@fi.uba.a [Laboratorio de Solidos Amorfos, INTECIN, Facultad de Ingenieria, UBA-CONICET, Paseo Colon 850, (C1063ACV) Buenos Aires (Argentina); Vlasak, G.; Svec, P.; Janickovic, D. [Institute of Physics, Slovak Academy of Sciences, Dubravska cesta 9, 845 11 Bratislava (Slovakia); Cremaschi, V.J., E-mail: vcremas@gmail.co [Laboratorio de Solidos Amorfos, INTECIN, Facultad de Ingenieria, UBA-CONICET, Paseo Colon 850, (C1063ACV) Buenos Aires (Argentina); Member of Carrera del Investigador, CONICET (Argentina)

    2010-09-15

    The magnetization behaviour of a ferromagnetic material depends on its domain structure, which in turn is largely determined by magnetic anisotropies. In this work, domain patterns were observed by a quite forgotten but still the simplest and the cheapest technique: the Bitter method. A systematic study of the evolution of the domain structure in FINEMET ribbons after thermal annealing is presented, correlating the results with the crystalline structure, magnetostriction and coercivity measurements.

  8. Summarization by domain ontology navigation

    DEFF Research Database (Denmark)

    Andreasen, Troels; Bulskov, Henrik

    2013-01-01

    A summary is a concise description that reflects the essence of a subject. A text, a collection of text documents, or a query answer can be summarized by simple means such as an automatically generated list of the most frequent words or “advanced” by a meaningful natural language description...... be a simple taxonomy or a generative domain ontology. A domain ontology can be provided by a preanalysis of a domain corpus and can be used to condense improved summaries that better reflects the conceptualization of a given domain....

  9. Structure of a two-CAP-domain protein from the human hookworm parasite Necator americanus

    Energy Technology Data Exchange (ETDEWEB)

    Asojo, Oluwatoyin A., E-mail: oasojo@unmc.edu [Pathology and Microbiology Department, 986495 Nebraska Medical Center, Omaha, NE 68198-6495 (United States)

    2011-05-01

    The first structure of a two-CAP-domain protein, Na-ASP-1, from the major human hookworm parasite N. americanus refined to a resolution limit of 2.2 Å is presented. Major proteins secreted by the infective larval stage hookworms upon host entry include Ancylostoma secreted proteins (ASPs), which are characterized by one or two CAP (cysteine-rich secretory protein/antigen 5/pathogenesis related-1) domains. The CAP domain has been reported in diverse phylogenetically unrelated proteins, but has no confirmed function. The first structure of a two-CAP-domain protein, Na-ASP-1, from the major human hookworm parasite Necator americanus was refined to a resolution limit of 2.2 Å. The structure was solved by molecular replacement (MR) using Na-ASP-2, a one-CAP-domain ASP, as the search model. The correct MR solution could only be obtained by truncating the polyalanine model of Na-ASP-2 and removing several loops. The structure reveals two CAP domains linked by an extended loop. Overall, the carboxyl-terminal CAP domain is more similar to Na-ASP-2 than to the amino-terminal CAP domain. A large central cavity extends from the amino-terminal CAP domain to the carboxyl-terminal CAP domain, encompassing the putative CAP-binding cavity. The putative CAP-binding cavity is a characteristic cavity in the carboxyl-terminal CAP domain that contains a His and Glu pair. These residues are conserved in all single-CAP-domain proteins, but are absent in the amino-terminal CAP domain. The conserved His residues are oriented such that they appear to be capable of directly coordinating a zinc ion as observed for CAP proteins from reptile venoms. This first structure of a two-CAP-domain ASP can serve as a template for homology modeling of other two-CAP-domain proteins.

  10. First experience with the new .cern Top Level Domain

    Science.gov (United States)

    Alvarez, E.; Malo de Molina, M.; Salwerowicz, M.; Silva De Sousa, B.; Smith, T.; Wagner, A.

    2017-10-01

    In October 2015, CERN’s core website has been moved to a new address, http://home.cern, marking the launch of the brand new top-level domain .cern. In combination with a formal governance and registration policy, the IT infrastructure needed to be extended to accommodate the hosting of Web sites in this new top level domain. We will present the technical implementation in the framework of the CERN Web Services that allows to provide virtual hosting, a reverse proxy solution and that also includes the provisioning of SSL server certificates for secure communications.

  11. EXTENDED SPEECH EMOTION RECOGNITION AND PREDICTION

    Directory of Open Access Journals (Sweden)

    Theodoros Anagnostopoulos

    2014-11-01

    Full Text Available Humans are considered to reason and act rationally and that is believed to be their fundamental difference from the rest of the living entities. Furthermore, modern approaches in the science of psychology underline that humans as a thinking creatures are also sentimental and emotional organisms. There are fifteen universal extended emotions plus neutral emotion: hot anger, cold anger, panic, fear, anxiety, despair, sadness, elation, happiness, interest, boredom, shame, pride, disgust, contempt and neutral position. The scope of the current research is to understand the emotional state of a human being by capturing the speech utterances that one uses during a common conversation. It is proved that having enough acoustic evidence available the emotional state of a person can be classified by a set of majority voting classifiers. The proposed set of classifiers is based on three main classifiers: kNN, C4.5 and SVM RBF Kernel. This set achieves better performance than each basic classifier taken separately. It is compared with two other sets of classifiers: one-against-all (OAA multiclass SVM with Hybrid kernels and the set of classifiers which consists of the following two basic classifiers: C5.0 and Neural Network. The proposed variant achieves better performance than the other two sets of classifiers. The paper deals with emotion classification by a set of majority voting classifiers that combines three certain types of basic classifiers with low computational complexity. The basic classifiers stem from different theoretical background in order to avoid bias and redundancy which gives the proposed set of classifiers the ability to generalize in the emotion domain space.

  12. On Probability Domains

    Science.gov (United States)

    Frič, Roman; Papčo, Martin

    2010-12-01

    Motivated by IF-probability theory (intuitionistic fuzzy), we study n-component probability domains in which each event represents a body of competing components and the range of a state represents a simplex S n of n-tuples of possible rewards-the sum of the rewards is a number from [0,1]. For n=1 we get fuzzy events, for example a bold algebra, and the corresponding fuzzy probability theory can be developed within the category ID of D-posets (equivalently effect algebras) of fuzzy sets and sequentially continuous D-homomorphisms. For n=2 we get IF-events, i.e., pairs ( μ, ν) of fuzzy sets μ, ν∈[0,1] X such that μ( x)+ ν( x)≤1 for all x∈ X, but we order our pairs (events) coordinatewise. Hence the structure of IF-events (where ( μ 1, ν 1)≤( μ 2, ν 2) whenever μ 1≤ μ 2 and ν 2≤ ν 1) is different and, consequently, the resulting IF-probability theory models a different principle. The category ID is cogenerated by I=[0,1] (objects of ID are subobjects of powers I X ), has nice properties and basic probabilistic notions and constructions are categorical. For example, states are morphisms. We introduce the category S n D cogenerated by Sn=\\{(x1,x2,ldots ,xn)in In;sum_{i=1}nxi≤ 1\\} carrying the coordinatewise partial order, difference, and sequential convergence and we show how basic probability notions can be defined within S n D.

  13. antimicrobial susceptibility pattern of extended spectrum

    African Journals Online (AJOL)

    JAMILU

    ABSTRACT. The emergence of resistant strains of urogenital extended spectrum beta-lactamase producing ... antimicrobial susceptibility test using CLSI recommended, WHO modified Kirby Bauer disc diffusion method. ... Keywords: Extended Spectrum Beta-lactamases, Prevalence, Gram-negative urogenital isolates,.

  14. Computational prediction of protein function based on weighted mapping of domains and GO terms.

    Science.gov (United States)

    Teng, Zhixia; Guo, Maozu; Dai, Qiguo; Wang, Chunyu; Li, Jin; Liu, Xiaoyan

    2014-01-01

    In this paper, we propose a novel method, SeekFun, to predict protein function based on weighted mapping of domains and GO terms. Firstly, a weighted mapping of domains and GO terms is constructed according to GO annotations and domain composition of the proteins. The association strength between domain and GO term is weighted by symmetrical conditional probability. Secondly, the mapping is extended along the true paths of the terms based on GO hierarchy. Finally, the terms associated with resident domains are transferred to host protein and real annotations of the host protein are determined by association strengths. Our careful comparisons demonstrate that SeekFun outperforms the concerned methods on most occasions. SeekFun provides a flexible and effective way for protein function prediction. It benefits from the well-constructed mapping of domains and GO terms, as well as the reasonable strategy for inferring annotations of protein from those of its domains.

  15. 42 CFR 488.310 - Extended survey.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Extended survey. 488.310 Section 488.310 Public...) STANDARDS AND CERTIFICATION SURVEY, CERTIFICATION, AND ENFORCEMENT PROCEDURES Survey and Certification of Long-Term Care Facilities § 488.310 Extended survey. (a) Purpose of survey. The purpose of an extended...

  16. Extended empirical likelihood for estimating equations

    OpenAIRE

    Min Tsao; Fan Wu

    2014-01-01

    We derive an extended empirical likelihood for parameters defined by estimating equations which generalizes the original empirical likelihood to the full parameter space. Under mild conditions, the extended empirical likelihood has all the asymptotic properties of the original empirical likelihood. The first-order extended empirical likelihood is easy to use and substantially more accurate than the original empirical likelihood.

  17. A quantum extended Kalman filter

    Science.gov (United States)

    Emzir, Muhammad F.; Woolley, Matthew J.; Petersen, Ian R.

    2017-06-01

    In quantum physics, a stochastic master equation (SME) estimates the state (density operator) of a quantum system in the Schrödinger picture based on a record of measurements made on the system. In the Heisenberg picture, the SME is a quantum filter. For a linear quantum system subject to linear measurements and Gaussian noise, the dynamics may be described by quantum stochastic differential equations (QSDEs), also known as quantum Langevin equations, and the quantum filter reduces to a so-called quantum Kalman filter. In this article, we introduce a quantum extended Kalman filter (quantum EKF), which applies a commutative approximation and a time-varying linearization to systems of nonlinear QSDEs. We will show that there are conditions under which a filter similar to a classical EKF can be implemented for quantum systems. The boundedness of estimation errors and the filtering problem with ‘state-dependent’ covariances for process and measurement noises are also discussed. We demonstrate the effectiveness of the quantum EKF by applying it to systems that involve multiple modes, nonlinear Hamiltonians, and simultaneous jump-diffusive measurements.

  18. Extended attention span training system

    Science.gov (United States)

    Pope, Alan T.; Bogart, Edward H.

    1991-01-01

    Attention Deficit Disorder (ADD) is a behavioral disorder characterized by the inability to sustain attention long enough to perform activities such as schoolwork or organized play. Treatments for this disorder include medication and brainwave biofeedback training. Brainwave biofeedback training systems feed back information to the trainee showing him how well he is producing the brainwave pattern that indicates attention. The Extended Attention Span Training (EAST) system takes the concept a step further by making a video game more difficult as the player's brainwaves indicate that attention is waning. The trainee can succeed at the game only by maintaining an adequate level of attention. The EAST system is a modification of a biocybernetic system that is currently being used to assess the extent to which automated flight management systems maintain pilot engagement. This biocybernetic system is a product of a program aimed at developing methods to evaluate automated flight deck designs for compatibility with human capabilities. The EAST technology can make a contribution in the fields of medical neuropsychology and neurology, where the emphasis is on cautious, conservative treatment of youngsters with attention disorders.

  19. The motivation behind extended suicide

    Directory of Open Access Journals (Sweden)

    Roman Kuruc

    2014-12-01

    Full Text Available The investigation of motivation of suicidal behaviour in cases of so-called extended suicide is of great importance from a forensic-psychological viewpoint. The initiator of such action is often a person suffering from endogenous depression. The motives behind successful suicide are generally not known. This paper aims to demonstrate the motives behind the successful suicide, less frequent in our conditions, of two family members – a father and a son. The case has been thoroughly analysed by morphological methods with the help of additional laboratory tests. At the centre was a suicide letter which was hidden in a very unusual way and which was elucidated only thanks to autopsy of both persons. The manner of realisation – hanging – was among the most frequent in the region and in the state too. The men were not under the influence of any toxic substances. The motivation behind the suicide was an escape from hard living conditions.

  20. The monocyte binding domain(s) on human immunoglobulin G.

    Science.gov (United States)

    Woof, J M; Nik Jaafar, M I; Jefferis, R; Burton, D R

    1984-06-01

    Monocyte binding has previously been assigned to the C gamma 3 domain of human immunoglobulin G (IgG) largely on the ability of the pFc' fragment to inhibit the monocyte-IgG interaction. This ability is markedly reduced compared to the intact parent IgG. We find this result with a conventional pFc' preparation but this preparation is found to contain trace contamination of parent IgG as demonstrated by reactivity with monoclonal antibodies directed against C gamma 2 domain and light-chain epitopes of human IgG. Extensive immunoaffinity purification of the pFc' preparation removes its inhibitory ability indicating that this originates in the trace contamination of parent IgG (or Fc). Neither of the human IgG1 paraproteins TIM, lacking the C gamma 2 domain, or SIZ, lacking the C gamma 3 domain, are found to inhibit the monocyte-IgG interaction. The hinge-deleted IgG1 Dob protein shows little or no inhibitory ability. Indirect evidence for the involvement of the C gamma 2 domain in monocyte binding is considered. We suggest finally that the site of interaction is found either on the C gamma 2 domain alone or between the C gamma 2 and C gamma 3 domains.

  1. Optimising predictor domains for spatially coherent precipitation downscaling

    Directory of Open Access Journals (Sweden)

    S. Radanovics

    2013-10-01

    Full Text Available Statistical downscaling is widely used to overcome the scale gap between predictors from numerical weather prediction models or global circulation models and predictands like local precipitation, required for example for medium-term operational forecasts or climate change impact studies. The predictors are considered over a given spatial domain which is rarely optimised with respect to the target predictand location. In this study, an extended version of the growing rectangular domain algorithm is proposed to provide an ensemble of near-optimum predictor domains for a statistical downscaling method. This algorithm is applied to find five-member ensembles of near-optimum geopotential predictor domains for an analogue downscaling method for 608 individual target zones covering France. Results first show that very similar downscaling performances based on the continuous ranked probability score (CRPS can be achieved by different predictor domains for any specific target zone, demonstrating the need for considering alternative domains in this context of high equifinality. A second result is the large diversity of optimised predictor domains over the country that questions the commonly made hypothesis of a common predictor domain for large areas. The domain centres are mainly distributed following the geographical location of the target location, but there are apparent differences between the windward and the lee side of mountain ridges. Moreover, domains for target zones located in southeastern France are centred more east and south than the ones for target locations on the same longitude. The size of the optimised domains tends to be larger in the southeastern part of the country, while domains with a very small meridional extent can be found in an east–west band around 47° N. Sensitivity experiments finally show that results are rather insensitive to the starting point of the optimisation algorithm except for zones located in the transition

  2. The role of IT for extended products' evolution into product service ecosystems

    NARCIS (Netherlands)

    Wortmann, Johan; Thoben, Klaus-Dieter; Emmanouilidis, Christos; Taisch, Marco; Kiritsis, Dimitris

    2013-01-01

    This paper elaborates on the notions of extended products and product service systems. It argues that product service systems evolve rapidly into offerings which cross traditional domains of competition, and move into service ecosystems. The paper investigates the role of ICT in the development of

  3. Pan-Cancer Analysis of Mutation Hotspots in Protein Domains.

    Science.gov (United States)

    Miller, Martin L; Reznik, Ed; Gauthier, Nicholas P; Aksoy, Bülent Arman; Korkut, Anil; Gao, Jianjiong; Ciriello, Giovanni; Schultz, Nikolaus; Sander, Chris

    2015-09-23

    In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of recurrence of mutations from single genes to gene families that share homologous protein domains. Domain mutation analysis also sharpens the functional interpretation of the impact of mutations, as domains more succinctly embody function than entire genes. By mapping mutations in 22 different tumor types to equivalent positions in multiple sequence alignments of domains, we confirm well-known functional mutation hotspots, identify uncharacterized rare variants in one gene that are equivalent to well-characterized mutations in another gene, detect previously unknown mutation hotspots, and provide hypotheses about molecular mechanisms and downstream effects of domain mutations. With the rapid expansion of cancer genomics projects, protein domain hotspot analysis will likely provide many more leads linking mutations in proteins to the cancer phenotype. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Improving developer productivity with C++ embedded domain specific languages

    Science.gov (United States)

    Kozacik, Stephen; Chao, Evenie; Paolini, Aaron; Bonnett, James; Kelmelis, Eric

    2017-05-01

    Domain-specific languages are a useful tool for productivity allowing domain experts to program using familiar concepts and vocabulary while benefiting from performance choices made by computing experts. Embedding the domain specific language into an existing language allows easy interoperability with non-domain-specific code and use of standard compilers and build systems. In C++, this is enabled through the template and preprocessor features. C++ embedded domain specific languages (EDSLs) allow the user to write simple, safe, performant, domain specific code that has access to all the low-level functionality that C and C++ offer as well as the diverse set of libraries available in the C/C++ ecosystem. In this paper, we will discuss several tools available for building EDSLs in C++ and show examples of projects successfully leveraging EDSLs. Modern C++ has added many useful new features to the language which we have leveraged to further extend the capability of EDSLs. At EM Photonics, we have used EDSLs to allow developers to transparently benefit from using high performance computing (HPC) hardware. We will show ways EDSLs combine with existing technologies and EM Photonics high performance tools and libraries to produce clean, short, high performance code in ways that were not previously possible.

  5. Domain walls riding the wave.

    Energy Technology Data Exchange (ETDEWEB)

    Karapetrov, G.; Novosad, V.; Materials Science Division

    2010-11-01

    Recent years have witnessed a rapid proliferation of electronic gadgets around the world. These devices are used for both communication and entertainment, and it is a fact that they account for a growing portion of household energy consumption and overall world consumption of electricity. Increasing the energy efficiency of these devices could have a far greater and immediate impact than a gradual switch to renewable energy sources. The advances in the area of spintronics are therefore very important, as gadgets are mostly comprised of memory and logic elements. Recent developments in controlled manipulation of magnetic domains in ferromagnet nanostructures have opened opportunities for novel device architectures. This new class of memories and logic gates could soon power millions of consumer electronic devices. The attractiveness of using domain-wall motion in electronics is due to its inherent reliability (no mechanical moving parts), scalability (3D scalable architectures such as in racetrack memory), and nonvolatility (retains information in the absence of power). The remaining obstacles in widespread use of 'racetrack-type' elements are the speed and the energy dissipation during the manipulation of domain walls. In their recent contribution to Physical Review Letters, Oleg Tretiakov, Yang Liu, and Artem Abanov from Texas A&M University in College Station, provide a theoretical description of domain-wall motion in nanoscale ferromagnets due to the spin-polarized currents. They find exact conditions for time-dependent resonant domain-wall movement, which could speed up the motion of domain walls while minimizing Ohmic losses. Movement of domain walls in ferromagnetic nanowires can be achieved by application of external magnetic fields or by passing a spin-polarized current through the nanowire itself. On the other hand, the readout of the domain state is done by measuring the resistance of the wire. Therefore, passing current through the

  6. Domain learning naming game for color categorization.

    Science.gov (United States)

    Li, Doujie; Fan, Zhongyan; Tang, Wallace K S

    2017-01-01

    Naming game simulates the evolution of vocabulary in a population of agents. Through pairwise interactions in the games, agents acquire a set of vocabulary in their memory for object naming. The existing model confines to a one-to-one mapping between a name and an object. Focus is usually put onto name consensus in the population rather than knowledge learning in agents, and hence simple learning model is usually adopted. However, the cognition system of human being is much more complex and knowledge is usually presented in a complicated form. Therefore, in this work, we extend the agent learning model and design a new game to incorporate domain learning, which is essential for more complicated form of knowledge. In particular, we demonstrate the evolution of color categorization and naming in a population of agents. We incorporate the human perceptive model into the agents and introduce two new concepts, namely subjective perception and subliminal stimulation, in domain learning. Simulation results show that, even without any supervision or pre-requisition, a consensus of a color naming system can be reached in a population solely via the interactions. Our work confirms the importance of society interactions in color categorization, which is a long debate topic in human cognition. Moreover, our work also demonstrates the possibility of cognitive system development in autonomous intelligent agents.

  7. DAML: domain adaptation metric learning.

    Science.gov (United States)

    Geng, Bo; Tao, Dacheng; Xu, Chao

    2011-10-01

    The state-of-the-art metric-learning algorithms cannot perform well for domain adaptation settings, such as cross-domain face recognition, image annotation, etc., because labeled data in the source domain and unlabeled ones in the target domain are drawn from different, but related distributions. In this paper, we propose the domain adaptation metric learning (DAML), by introducing a data-dependent regularization to the conventional metric learning in the reproducing kernel Hilbert space (RKHS). This data-dependent regularization resolves the distribution difference by minimizing the empirical maximum mean discrepancy between source and target domain data in RKHS. Theoretically, by using the empirical Rademacher complexity, we prove risk bounds for the nearest neighbor classifier that uses the metric learned by DAML. Practically, learning the metric in RKHS does not scale up well. Fortunately, we can prove that learning DAML in RKHS is equivalent to learning DAML in the space spanned by principal components of the kernel principle component analysis (KPCA). Thus, we can apply KPCA to select most important principal components to significantly reduce the time cost of DAML. We perform extensive experiments over four well-known face recognition datasets and a large-scale Web image annotation dataset for the cross-domain face recognition and image annotation tasks under various settings, and the results demonstrate the effectiveness of DAML. © 2011 IEEE

  8. Predicting domain-domain interaction based on domain profiles with feature selection and support vector machines

    Directory of Open Access Journals (Sweden)

    Liao Li

    2010-10-01

    Full Text Available Abstract Background Protein-protein interaction (PPI plays essential roles in cellular functions. The cost, time and other limitations associated with the current experimental methods have motivated the development of computational methods for predicting PPIs. As protein interactions generally occur via domains instead of the whole molecules, predicting domain-domain interaction (DDI is an important step toward PPI prediction. Computational methods developed so far have utilized information from various sources at different levels, from primary sequences, to molecular structures, to evolutionary profiles. Results In this paper, we propose a computational method to predict DDI using support vector machines (SVMs, based on domains represented as interaction profile hidden Markov models (ipHMM where interacting residues in domains are explicitly modeled according to the three dimensional structural information available at the Protein Data Bank (PDB. Features about the domains are extracted first as the Fisher scores derived from the ipHMM and then selected using singular value decomposition (SVD. Domain pairs are represented by concatenating their selected feature vectors, and classified by a support vector machine trained on these feature vectors. The method is tested by leave-one-out cross validation experiments with a set of interacting protein pairs adopted from the 3DID database. The prediction accuracy has shown significant improvement as compared to InterPreTS (Interaction Prediction through Tertiary Structure, an existing method for PPI prediction that also uses the sequences and complexes of known 3D structure. Conclusions We show that domain-domain interaction prediction can be significantly enhanced by exploiting information inherent in the domain profiles via feature selection based on Fisher scores, singular value decomposition and supervised learning based on support vector machines. Datasets and source code are freely available on

  9. CCR+: Metadata Based Extended Personal Health Record Data Model Interoperable with the ASTM CCR Standard.

    Science.gov (United States)

    Park, Yu Rang; Yoon, Young Jo; Jang, Tae Hun; Seo, Hwa Jeong; Kim, Ju Han

    2014-01-01

    Extension of the standard model while retaining compliance with it is a challenging issue because there is currently no method for semantically or syntactically verifying an extended data model. A metadata-based extended model, named CCR+, was designed and implemented to achieve interoperability between standard and extended models. Furthermore, a multilayered validation method was devised to validate the standard and extended models. The American Society for Testing and Materials (ASTM) Community Care Record (CCR) standard was selected to evaluate the CCR+ model; two CCR and one CCR+ XML files were evaluated. In total, 188 metadata were extracted from the ASTM CCR standard; these metadata are semantically interconnected and registered in the metadata registry. An extended-data-model-specific validation file was generated from these metadata. This file can be used in a smartphone application (Health Avatar CCR+) as a part of a multilayered validation. The new CCR+ model was successfully evaluated via a patient-centric exchange scenario involving multiple hospitals, with the results supporting both syntactic and semantic interoperability between the standard CCR and extended, CCR+, model. A feasible method for delivering an extended model that complies with the standard model is presented herein. There is a great need to extend static standard models such as the ASTM CCR in various domains: the methods presented here represent an important reference for achieving interoperability between standard and extended models.

  10. An Integrated Framework to Specify Domain-Specific Modeling Languages

    DEFF Research Database (Denmark)

    Zarrin, Bahram; Baumeister, Hubert

    2018-01-01

    In this paper, we propose an integrated framework that can be used by DSL designers to implement their desired graphical domain-specific languages. This framework relies on Microsoft DSL Tools, a meta-modeling framework to build graphical domain-specific languages, and an extension of For......Spec, a logic-based specification language. The drawback of MS DSL Tools is it does not provide a formal and rigorous approach for semantics specifications. In this framework, we use Microsoft DSL Tools to define the metamodel and graphical notations of DSLs, and an extended version of ForSpec as a formal...... language to define their semantics. Integrating these technologies under the umbrella of Microsoft Visual Studio IDE allows DSL designers to utilize a single development environment for developing their desired domain-specific languages....

  11. Wavefield extrapolation in pseudodepth domain

    KAUST Repository

    Ma, Xuxin

    2013-02-01

    Wavefields are commonly computed in the Cartesian coordinate frame. Its efficiency is inherently limited due to spatial oversampling in deep layers, where the velocity is high and wavelengths are long. To alleviate this computational waste due to uneven wavelength sampling, we convert the vertical axis of the conventional domain from depth to vertical time or pseudodepth. This creates a nonorthognal Riemannian coordinate system. Isotropic and anisotropic wavefields can be extrapolated in the new coordinate frame with improved efficiency and good consistency with Cartesian domain extrapolation results. Prestack depth migrations are also evaluated based on the wavefield extrapolation in the pseudodepth domain.© 2013 Society of Exploration Geophysicists. All rights reserved.

  12. Comparative Analysis of Protein Domain Organization

    OpenAIRE

    Ye, Yuzhen; Godzik, Adam

    2004-01-01

    We have developed a set of graph theory-based tools, which we call Comparative Analysis of Protein Domain Organization (CADO), to survey and compare protein domain organizations of different organisms. In the language of CADO, the organization of protein domains in a given organism is shown as a domain graph in which protein domains are represented as vertices, and domain combinations, defined as instances of two domains found in one protein, are represented as edges. CADO provides a new way ...

  13. Stability of simultaneously triangularizable switched systems on hybrid domains

    Directory of Open Access Journals (Sweden)

    Geoffrey Eisenbarth

    2014-03-01

    Full Text Available In this paper, we extend the results of [8, 15, 22], which provide sufficient conditions for the global exponential stability of switched systems under arbitrary switching via the existence of a common quadratic Lyapunov function. In particular, we extend the Lie algebraic results in [15] to switched systems with hybrid non-uniform discrete and continuous domains, a direct unifying generalization of switched systems on R and Z, and extend the results in [8, 22] to a larger class of switched systems, namely those whose subsystem matrices are simultaneously triangularizable. In addition, we explore an easily checkable characterization of our required hypotheses for the theorems. Finally, conditions are provided under which there exists a stabilizing switching pattern for a collection of (not necessarily stable linear systems that are simultaneously triangularizable and separate criteria are formed which imply the stability of the system under a given switching pattern given a priori.

  14. Texture of lipid bilayer domains

    DEFF Research Database (Denmark)

    Jensen, Uffe Bernchou; Brewer, Jonathan R.; Midtiby, Henrik Skov

    2009-01-01

    which correlates with the phase state of the membrane. This is quantified by the generalized polarization (GP) function, and we demonstrate that a GP analysis can be performed on supported membranes. The results show that although the gel domains have heterogeneous texture, the membrane phase state does......We investigate the texture of gel (g) domains in binary lipid membranes composed of the phospholipids DPPC and DOPC. Lateral organization of lipid bilayer membranes is a topic of fundamental and biological importance. Whereas questions related to size and composition of fluid membrane domain...... are well studied, the possibility of texture in gel domains has so far not been examined. When using polarized light for two-photon excitation of the fluorescent lipid probe Laurdan, the emission intensity is highly sensitive to the angle between the polarization and the tilt orientation of lipid acyl...

  15. Function analysis of a new type I PKS-SAT domain by SAT-EAT domain replacement.

    Science.gov (United States)

    Jiao, Y L; Wang, L H; Jiao, B H; Wang, S J; Fang, Y W; Liu, S

    2010-01-01

    The function of a new starter unit acyltransferase (SAT) domain SAT-EF080951 (GenBank accession number) encoded in a new type I polyketide synthase (PKS) gene cluster EF568935 (GenBank accession number) isolated for this study was analyzed by domain replacement with an extender unit AT (EAT) domain of avermectin PKS. It was shown that the SAT-EF080951 incorporated malonyl-CoA specifically in vivo, which contradicted the specificity that we had previously determined by substrate binding test in vitro. The result of this study indicates that type I PKS-SAT can alter its specificity in vivo and functions well in extender units and proved the feasibility of the SAT-EAT domain replacement in type I PKS. We propose that SAT-EAT replacement strategy could be a novel route for increasing the diversity of new polyketides combinatorially biosynthesized. The new type I PKS-SAT-EF080951 studied herein may be further employed for related studies on enzymology or combinatorial biosynthesis of polyketides.

  16. Fatou-Bieberbach domains in

    Science.gov (United States)

    Forstnerič, Franc; Wold, Erlend F.

    2015-10-01

    We construct Fatou-Bieberbach domains in for n>1 which contain a given compact set K and at the same time avoid a totally real affine subspace L of dimension < n, provided that K∪ L is polynomially convex. By using this result, we show that the domain for 1≤ k< n enjoys the basic Oka property with approximation for maps from any Stein manifold of dimension < n.

  17. A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.

    Directory of Open Access Journals (Sweden)

    Yongqian Zhao

    2015-03-01

    Full Text Available Flavivirus RNA replication occurs within a replication complex (RC that assembles on ER membranes and comprises both non-structural (NS viral proteins and host cofactors. As the largest protein component within the flavivirus RC, NS5 plays key enzymatic roles through its N-terminal methyltransferase (MTase and C-terminal RNA-dependent-RNA polymerase (RdRp domains, and constitutes a major target for antivirals. We determined a crystal structure of the full-length NS5 protein from Dengue virus serotype 3 (DENV3 at a resolution of 2.3 Å in the presence of bound SAH and GTP. Although the overall molecular shape of NS5 from DENV3 resembles that of NS5 from Japanese Encephalitis Virus (JEV, the relative orientation between the MTase and RdRp domains differs between the two structures, providing direct evidence for the existence of a set of discrete stable molecular conformations that may be required for its function. While the inter-domain region is mostly disordered in NS5 from JEV, the NS5 structure from DENV3 reveals a well-ordered linker region comprising a short 310 helix that may act as a swivel. Solution Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS analysis reveals an increased mobility of the thumb subdomain of RdRp in the context of the full length NS5 protein which correlates well with the analysis of the crystallographic temperature factors. Site-directed mutagenesis targeting the mostly polar interface between the MTase and RdRp domains identified several evolutionarily conserved residues that are important for viral replication, suggesting that inter-domain cross-talk in NS5 regulates virus replication. Collectively, a picture for the molecular origin of NS5 flexibility is emerging with profound implications for flavivirus replication and for the development of therapeutics targeting NS5.

  18. Extended empirical likelihood for general estimating equations

    OpenAIRE

    Tsao, Min; Wu, Fan

    2013-01-01

    We derive an extended empirical likelihood for parameters defined by estimating equations which generalizes the original empirical likelihood for such parameters to the full parameter space. Under mild conditions, the extended empirical likelihood has all asymptotic properties of the original empirical likelihood. Its contours retain the data-driven shape of the latter. It can also attain the second order accuracy. The first order extended empirical likelihood is easy-to-use yet it is substan...

  19. An algebraic approach to symmetric extended formulations

    OpenAIRE

    Braun, Gábor; Pokutta, Sebastian

    2012-01-01

    Extended formulations are an important tool to obtain small (even compact) formulations of polytopes by representing them as projections of higher dimensional ones. It is an important question whether a polytope admits a small extended formulation, i.e., one involving only a polynomial number of inequalities in its dimension. For the case of symmetric extended formulations (i.e., preserving the symmetries of the polytope) Yannakakis established a powerful technique to derive lower bounds and ...

  20. Domain Decomposition Solvers for Frequency-Domain Finite Element Equations

    KAUST Repository

    Copeland, Dylan

    2010-10-05

    The paper is devoted to fast iterative solvers for frequency-domain finite element equations approximating linear and nonlinear parabolic initial boundary value problems with time-harmonic excitations. Switching from the time domain to the frequency domain allows us to replace the expensive time-integration procedure by the solution of a simple linear elliptic system for the amplitudes belonging to the sine- and to the cosine-excitation or a large nonlinear elliptic system for the Fourier coefficients in the linear and nonlinear case, respectively. The fast solution of the corresponding linear and nonlinear system of finite element equations is crucial for the competitiveness of this method. © 2011 Springer-Verlag Berlin Heidelberg.

  1. Mapping hyper-extended rift systems offshore and onshore: insights from the Bay of Biscay- Western Pyrenees

    Science.gov (United States)

    Tugend, Julie; Manatschal, Gianreto; Kusznir, Nicolas J.; Masini, Emmanuel; Thinon, Isabelle

    2013-04-01

    Research conducted at present-day passive continental margins shows more varied crustal architectures than previously assumed. New seismic data together with drill-holes have revealed the occurrence of extremely thinned continental crust in the distal part of the margin as well as exhumed serpentinised sub-continental mantle oceanwards. In addition the understanding of the formation of hyper-extended rift systems has also greatly benefited from the study of onshore analogs preserved in mountain belts. The Bay of Biscay and Western Pyrenees correspond to a Lower Cretaceous rift system leading to the development of hyper-extended domains and ultimately oceanic crust in the Bay of Biscay. This domain represents one of the best natural laboratories to study the formation processes and evolution of hyper-extended domains. During late Cretaceous compression, these rifted domains were inverted resulting in the present-day Pyrenean mountain belt. In this contribution, we present a new paleogeographic map of the Bay of Biscay-Pyrenean rift system. We integrate results from previous works and new work using different mapping methods to distinguish distinctive crustal domains related to hyper-extended systems both offshore and onshore. We combine seismic interpretations with gravity anomaly inversion and residual depth anomaly analysis to distinguish the different crustal domains across the offshore margin. Onshore, we use an innovative approach based on observations from present-day rifted margin architecture associated with classical field work to map the former hyper-extended domains. Another outcome of this work is the creation of a crustal thickness map using gravity inversion linking offshore and onshore domains from the Bay of Biscay to that of the Western-Pyrenees. This multidisciplinary approach enables us to investigate the spatial and temporal evolution of the Bay of Biscay rift system with the aim of better understanding the formation of hyper-extended domains

  2. The organization of domains in proteins obeys Menzerath-Altmann's law of language.

    Science.gov (United States)

    Shahzad, Khuram; Mittenthal, Jay E; Caetano-Anollés, Gustavo

    2015-08-11

    The combination of domains in multidomain proteins enhances their function and structure but lengthens the molecules and increases their cost at cellular level. The dependence of domain length on the number of domains a protein holds was surveyed for a set of 60 proteomes representing free-living organisms from all kingdoms of life. Distributions were fitted using non-linear functions and fitted parameters interpreted with a formulation of decreasing returns. We find that domain length decreases with increasing number of domains in proteins, following the Menzerath-Altmann (MA) law of language. Highly significant negative correlations exist for the set of proteomes examined. Mathematically, the MA law expresses as a power law relationship that unfolds when molecular persistence P is a function of domain accretion. P holds two terms, one reflecting the matter-energy cost of adding domains and extending their length, the other reflecting how domain length and number impinges on information and biophysics. The pattern of diminishing returns can therefore be explained as a frustrated interplay between the strategies of economy, flexibility and robustness, matching previously observed trade-offs in the domain makeup of proteomes. Proteomes of Archaea, Fungi and to a lesser degree Plants show the largest push towards molecular economy, each at their own economic stratum. Fungi increase domain size in single domain proteins while reinforcing the pattern of diminishing returns. In contrast, Metazoa, and to lesser degrees Protista and Bacteria, relax economy. Metazoa achieves maximum flexibility and robustness by harboring compact molecules and complex domain organization, offering a new functional vocabulary for molecular biology. The tendency of parts to decrease their size when systems enlarge is universal for language and music, and now for parts of macromolecules, extending the MA law to natural systems.

  3. Structural Basis for Endosomal Targeting by the Bro1 Domain

    Science.gov (United States)

    Kim, Jaewon; Sitaraman, Sujatha; Hierro, Aitor; Beach, Bridgette M.; Odorizzi, Greg; Hurley, James H.

    2010-01-01

    Summary Proteins delivered to the lysosome or the yeast vacuole via late endosomes are sorted by the ESCRT complexes and by associated proteins, including Alix and its yeast homolog Bro1. Alix, Bro1, and several other late endosomal proteins share a conserved 160 residue Bro1 domain whose boundaries, structure, and function have not been characterized. The crystal structure of the Bro1 domain of Bro1 reveals a folded core of 367 residues. The extended Bro1 domain is necessary and sufficient for binding to the ESCRT-III subunit Snf7 and for the recruitment of Bro1 to late endosomes. The structure resembles a boomerang with its concave face filled in and contains a triple tetratricopeptide repeat domain as a substructure. Snf7 binds to a conserved hydrophobic patch on Bro1 that is required for protein complex formation and for the protein-sorting function of Bro1. These results define a conserved mechanism whereby Bro1 domain-containing proteins are targeted to endosomes by Snf7 and its orthologs. PMID:15935782

  4. Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.

    Science.gov (United States)

    Zhai, Qianting; Landesman, Michael B; Robinson, Howard; Sundquist, Wesley I; Hill, Christopher P

    2011-01-01

    Bro1 domains are elongated, banana-shaped domains that were first identified in the yeast ESCRT pathway protein, Bro1p. Humans express three Bro1 domain-containing proteins: ALIX, BROX, and HD-PTP, which function in association with the ESCRT pathway to help mediate intraluminal vesicle formation at multivesicular bodies, the abscission stage of cytokinesis, and/or enveloped virus budding. Human Bro1 domains share the ability to bind the CHMP4 subset of ESCRT-III proteins, associate with the HIV-1 NC(Gag) protein, and stimulate the budding of viral Gag proteins. The curved Bro1 domain structure has also been proposed to mediate membrane bending. To date, crystal structures have only been available for the related Bro1 domains from the Bro1p and ALIX proteins, and structures of additional family members should therefore aid in the identification of key structural and functional elements. We report the crystal structure of the human BROX protein, which comprises a single Bro1 domain. The Bro1 domains from BROX, Bro1p and ALIX adopt similar overall structures and share two common exposed hydrophobic surfaces. Surface 1 is located on the concave face and forms the CHMP4 binding site, whereas Surface 2 is located at the narrow end of the domain. The structures differ in that only ALIX has an extended loop that projects away from the convex face to expose the hydrophobic Phe105 side chain at its tip. Functional studies demonstrated that mutations in Surface 1, Surface 2, or Phe105 all impair the ability of ALIX to stimulate HIV-1 budding. Our studies reveal similarities in the overall folds and hydrophobic protein interaction sites of different Bro1 domains, and show that a unique extended loop contributes to the ability of ALIX to function in HIV-1 budding.

  5. Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding.

    Directory of Open Access Journals (Sweden)

    Qianting Zhai

    Full Text Available Bro1 domains are elongated, banana-shaped domains that were first identified in the yeast ESCRT pathway protein, Bro1p. Humans express three Bro1 domain-containing proteins: ALIX, BROX, and HD-PTP, which function in association with the ESCRT pathway to help mediate intraluminal vesicle formation at multivesicular bodies, the abscission stage of cytokinesis, and/or enveloped virus budding. Human Bro1 domains share the ability to bind the CHMP4 subset of ESCRT-III proteins, associate with the HIV-1 NC(Gag protein, and stimulate the budding of viral Gag proteins. The curved Bro1 domain structure has also been proposed to mediate membrane bending. To date, crystal structures have only been available for the related Bro1 domains from the Bro1p and ALIX proteins, and structures of additional family members should therefore aid in the identification of key structural and functional elements.We report the crystal structure of the human BROX protein, which comprises a single Bro1 domain. The Bro1 domains from BROX, Bro1p and ALIX adopt similar overall structures and share two common exposed hydrophobic surfaces. Surface 1 is located on the concave face and forms the CHMP4 binding site, whereas Surface 2 is located at the narrow end of the domain. The structures differ in that only ALIX has an extended loop that projects away from the convex face to expose the hydrophobic Phe105 side chain at its tip. Functional studies demonstrated that mutations in Surface 1, Surface 2, or Phe105 all impair the ability of ALIX to stimulate HIV-1 budding.Our studies reveal similarities in the overall folds and hydrophobic protein interaction sites of different Bro1 domains, and show that a unique extended loop contributes to the ability of ALIX to function in HIV-1 budding.

  6. Structure of the Bro1 Domain Protein BROX and Functional Analyses of the ALIX Bro1 Domain in HIV-1 Budding

    Energy Technology Data Exchange (ETDEWEB)

    Zhai Q.; Robinson H.; Landesman M. B.; Sundquist W. I.; Hill C. P.

    2011-12-01

    Bro1 domains are elongated, banana-shaped domains that were first identified in the yeast ESCRT pathway protein, Bro1p. Humans express three Bro1 domain-containing proteins: ALIX, BROX, and HD-PTP, which function in association with the ESCRT pathway to help mediate intraluminal vesicle formation at multivesicular bodies, the abscission stage of cytokinesis, and/or enveloped virus budding. Human Bro1 domains share the ability to bind the CHMP4 subset of ESCRT-III proteins, associate with the HIV-1 NC{sup Gag} protein, and stimulate the budding of viral Gag proteins. The curved Bro1 domain structure has also been proposed to mediate membrane bending. To date, crystal structures have only been available for the related Bro1 domains from the Bro1p and ALIX proteins, and structures of additional family members should therefore aid in the identification of key structural and functional elements. We report the crystal structure of the human BROX protein, which comprises a single Bro1 domain. The Bro1 domains from BROX, Bro1p and ALIX adopt similar overall structures and share two common exposed hydrophobic surfaces. Surface 1 is located on the concave face and forms the CHMP4 binding site, whereas Surface 2 is located at the narrow end of the domain. The structures differ in that only ALIX has an extended loop that projects away from the convex face to expose the hydrophobic Phe105 side chain at its tip. Functional studies demonstrated that mutations in Surface 1, Surface 2, or Phe105 all impair the ability of ALIX to stimulate HIV-1 budding. Our studies reveal similarities in the overall folds and hydrophobic protein interaction sites of different Bro1 domains, and show that a unique extended loop contributes to the ability of ALIX to function in HIV-1 budding.

  7. Developing a modular hydrogeology ontology by extending the SWEET upper-level ontologies

    Science.gov (United States)

    Tripathi, Ajay; Babaie, Hassan A.

    2008-09-01

    Upper-level ontologies comprise general concepts and properties which need to be extended to include more diverse and specific domain vocabularies. We present the extension of NASA's Semantic Web for Earth and Environmental Terminology (SWEET) ontologies to include part of the hydrogeology domain. We describe a methodology that can be followed by other allied domain experts who intend to adopt the SWEET ontologies in their own discipline. We have maintained the modular design of the SWEET ontologies for maximum extensibility and reusability of our ontology in other fields, to ensure inter-disciplinary knowledge reuse, management, and discovery. The extension of the SWEET ontologies involved identification of the general SWEET concepts (classes) to serve as the super-class of the domain concepts. This was followed by establishing the special inter-relationships between domain concepts (e.g., equivalence for vadose zone and unsaturated zone), and identifying the dependent concepts such as physical properties and units, and their relationship to external concepts. Ontology editing tools such as SWOOP and Protégé were used to analyze and visualize the structure of the existing OWL files. Domain concepts were introduced either as standalone new classes or as subclasses of existing SWEET ontologies. This involved changing the relationships (properties) and/or adding new relationships based on domain theories. In places, in the Owl files, the entire structure of the existing concepts needed to be changed to represent the domain concept more meaningfully. Throughout this process, the orthogonal structure of SWEET ontologies was maintained and the consistency of the concepts was tested using the Racer reasoner. Individuals were added to the new concepts to test the modified ontologies. Our work shows that SWEET ontologies can successfully be extended and reused in any field without losing their modular or reference structure, or disrupting their URI links.

  8. ADD, LD and Extended Information Processing.

    Science.gov (United States)

    Stolzenberg, J. B.; Cherkes-Julkowski, M.

    This study examines executive function and its relationship to attention dysfunction and working memory. It attempts to document the manifestations of executive function problems in school-related extended processing tasks, such as verbal problem-solving in math and reading of extended passages. Subjects (in grades 1-12) included 49 children with…

  9. Extended, Embodied Cognition and Second Language Acquisition

    Science.gov (United States)

    Atkinson, Dwight

    2010-01-01

    A "cognitivist" approach to cognition has traditionally dominated second language acquisition (SLA) studies. In this article, I examine two alternative approaches--"extended cognition" and "embodied cognition"--for how they might help us conceptualize SLA. More specifically, I present: (i) summaries of extended and embodied cognition, followed by…

  10. Functional domain walls in multiferroics.

    Science.gov (United States)

    Meier, Dennis

    2015-11-25

    During the last decade a wide variety of novel and fascinating correlation phenomena has been discovered at domain walls in multiferroic bulk systems, ranging from unusual electronic conductance to inseparably entangled spin and charge degrees of freedom. The domain walls represent quasi-2D functional objects that can be induced, positioned, and erased on demand, bearing considerable technological potential for future nanoelectronics. Most of the challenges that remain to be solved before turning related device paradigms into reality, however, still fall in the field of fundamental condensed matter physics and materials science. In this topical review seminal experimental findings gained on electric and magnetic domain walls in multiferroic bulk materials are addressed. A special focus is put on the physical properties that emerge at so-called charged domain walls and the added functionality that arises from coexisting magnetic order. The research presented in this review highlights that we are just entering a whole new world of intriguing nanoscale physics that is yet to be explored in all its details. The goal is to draw attention to the persistent challenges and identify future key directions for the research on functional domain walls in multiferroics.

  11. Inferring Domain-Domain Interactions from Protein-Protein Interactions with Formal Concept Analysis

    OpenAIRE

    Susan Khor

    2014-01-01

    Identifying reliable domain-domain interactions will increase our ability to predict novel protein-protein interactions, to unravel interactions in protein complexes, and thus gain more information about the function and behavior of genes. One of the challenges of identifying reliable domain-domain interactions is domain promiscuity. Promiscuous domains are domains that can occur in many domain architectures and are therefore found in many proteins. This becomes a problem for a method where t...

  12. Strontium doping of bone graft extender

    Science.gov (United States)

    2011-01-01

    Background and purpose Allografts are often used during revision hip replacement surgery for stabilization of the implant. Resorption of the allograft may exceed new bone formation, and instability of the prosthesis can develop. We investigated whether strontium could regulate the imbalance of fast resorption of allograft and slower formation of new bone, because it is both an anabolic and an anticatabolic agent. Method Strontium was added to the implant interface environment by doping a hydroxyapatite bone graft extender. 10 dogs each received 2 experimental titanium implants. The implants were inserted within a 2.7-mm concentric gap in cancellous bone. The gap was filled with 50% (v/v) allograft mixed with 50% bone graft extender. The extender either had 5% strontium doping (SrHA) or was undoped (HA). After 4 weeks, osseointegration and mechanical fixation were evaluated by histomorphometry and by push-out test. Results SrHA bone graft extender induced a 1.2-fold increase in volume of new bone, a 1.2-fold increase in allograft remaining in the gap, and a 1.4-fold increase in surface area of the bone graft extender material in contact with new bone compared to HA bone graft extender. All these increases were statistically significant. SrHA bone graft extender did not significantly improve ongrowth of bone onto the implants or improve any of the mechanical push-out parameters compared to HA bone graft extender. Interpretation Doping of the HA bone graft extender with 5% strontium increased gap healing, preserved more of the allograft in the gap, and increased the ongrowth of bone onto the bone graft extender material, but did not improve mechanical fixation. PMID:21895497

  13. Novel functions of CCM1 delimit the relationship of PTB/PH domains.

    Science.gov (United States)

    Zhang, Jun; Dubey, Pallavi; Padarti, Akhil; Zhang, Aileen; Patel, Rinkal; Patel, Vipulkumar; Cistola, David; Badr, Ahmed

    2017-10-01

    relationship of PTB, PH and FERM domains has been proposed, which extends the importance of the NPXY-PTB/PH interaction on the CSC signaling and/or other cell receptors with great potential pointing to new therapeutic strategies. The study provides new insight into the structural characteristics of PTB/PH domains, essential structural elements of PTB/PH domain required for NPXY motif-binding, and function and relationship among PTB, PH and FERM domains. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Learning processes across knowledge domains

    DEFF Research Database (Denmark)

    Hall-Andersen, Lene Bjerg; Broberg, Ole

    2014-01-01

    Purpose - The purpose of this paper is to shed light on the problematics of learning across knowledge boundaries in organizational settings. The paper specifically explores learning processes that emerge, when a new knowledge domain is introduced into an existing organizational practice...... with the aim of creating a new combined practice. Design/methodology/approach - A case study was carried out as a "natural experiment" in an engineering consultancy, where emerging initiatives to integrate the newly acquired competencies into the existing practice were explored. A theoretical framework...... organization, it remained discrete in 'pockets' of learning; mainly at an individual level, at project level or as domain-specific learning. Learning processes were intertwined with elements of domain-specific interests, power, managerial support, structural conditions, material and epistemic differences...

  15. Domain similarity based orthology detection.

    Science.gov (United States)

    Bitard-Feildel, Tristan; Kemena, Carsten; Greenwood, Jenny M; Bornberg-Bauer, Erich

    2015-05-13

    Orthologous protein detection software mostly uses pairwise comparisons of amino-acid sequences to assert whether two proteins are orthologous or not. Accordingly, when the number of sequences for comparison increases, the number of comparisons to compute grows in a quadratic order. A current challenge of bioinformatic research, especially when taking into account the increasing number of sequenced organisms available, is to make this ever-growing number of comparisons computationally feasible in a reasonable amount of time. We propose to speed up the detection of orthologous proteins by using strings of domains to characterize the proteins. We present two new protein similarity measures, a cosine and a maximal weight matching score based on domain content similarity, and new software, named porthoDom. The qualities of the cosine and the maximal weight matching similarity measures are compared against curated datasets. The measures show that domain content similarities are able to correctly group proteins into their families. Accordingly, the cosine similarity measure is used inside porthoDom, the wrapper developed for proteinortho. porthoDom makes use of domain content similarity measures to group proteins together before searching for orthologs. By using domains instead of amino acid sequences, the reduction of the search space decreases the computational complexity of an all-against-all sequence comparison. We demonstrate that representing and comparing proteins as strings of discrete domains, i.e. as a concatenation of their unique identifiers, allows a drastic simplification of search space. porthoDom has the advantage of speeding up orthology detection while maintaining a degree of accuracy similar to proteinortho. The implementation of porthoDom is released using python and C++ languages and is available under the GNU GPL licence 3 at http://www.bornberglab.org/pages/porthoda .

  16. A binomial modeling approach for upscaling colloid transport under unfavorable conditions: organic prediction of extended tailing

    Science.gov (United States)

    Hilpert, Markus; Rasmuson, Anna; Johnson, William

    2017-04-01

    Transport of colloids in saturated porous media is significantly influenced by colloidal interactions with grain surfaces. Near-surface fluid domain colloids experience relatively low fluid drag and relatively strong colloidal forces that slow their down-gradient translation relative to colloids in bulk fluid. Near surface fluid domain colloids may re-enter into the bulk fluid via diffusion (nanoparticles) or expulsion at rear flow stagnation zones, they may immobilize (attach) via strong primary minimum interactions, or they may move along a grain-to-grain contact to the near surface fluid domain of an adjacent grain. We introduce a simple model that accounts for all possible permutations of mass transfer within a dual pore and grain network. The primary phenomena thereby represented in the model are mass transfer of colloids between the bulk and near-surface fluid domains and immobilization onto grain surfaces. Colloid movement is described by a sequence of trials in a series of unit cells, and the binomial distribution is used to calculate the probabilities of each possible sequence. Pore-scale simulations provide mechanistically-determined likelihoods and timescales associated with the above pore-scale colloid mass transfer processes, whereas the network-scale model employs pore and grain topology to determine probabilities of transfer from up-gradient bulk and near-surface fluid domains to down-gradient bulk and near-surface fluid domains. Inter-grain transport of colloids in the near surface fluid domain can cause extended tailing.

  17. Time Domain Radar Laboratory Operating System Development and Transient EM Analysis.

    Science.gov (United States)

    1981-09-01

    sonopole Pulse Response All receiving antennas are coupled to the Signal Processing Group through a coaxial end-coupling fitted through the imaging plane...The Operating System has been correspondingly 97 written in this language. However, BASIC as used by the GS has been extended to fit the language to...DPO service request. Flag P7 (indicates whether the acquired data is destined for use in Time Domain or Prony Methods) is set to 0 (Time Domain) in

  18. An extended differentiated optical services model for WDM optical networks

    Science.gov (United States)

    Ouyang, Yong; Zeng, Qingji; Wei, Wei

    2004-04-01

    The need to provide QoS-guaranteed services in the WDM optical networks is becoming increasingly important because of a variety of candidate client networks (e.g., IP, ATM, SONET/SDH) and the requirement for QoS-delivery within the transport layers. This article addresses the QoS problem and presents a framework of QoS provisioning in the WDM optical network. We first characterize the QoS problem in the WDM optical network by comparing with that in the traditional networks. Then we propose a QoS service model in the optical domain called extended differentiated optical services (E-DoS) model based on a set of optical parameters that captures the quality, the reliability and the priority of an optical connection. Each component of the E-DoS model has been analyzed in detail in this article.

  19. International Conference eXtended Discretization MethodS

    CERN Document Server

    Benvenuti, Elena

    2016-01-01

    This book gathers selected contributions on emerging research work presented at the International Conference eXtended Discretization MethodS (X-DMS), held in Ferrara in September 2015. It highlights the most relevant advances made at the international level in the context of expanding classical discretization methods, like finite elements, to the numerical analysis of a variety of physical problems. The improvements are intended to achieve higher computational efficiency and to account for special features of the solution directly in the approximation space and/or in the discretization procedure. The methods described include, among others, partition of unity methods (meshfree, XFEM, GFEM), virtual element methods, fictitious domain methods, and special techniques for static and evolving interfaces. The uniting feature of all contributions is the direct link between computational methodologies and their application to different engineering areas.

  20. Domain specific MT in use

    DEFF Research Database (Denmark)

    Offersgaard, Lene; Povlsen, Claus; Almsten, Lisbeth Kjeldgaard

    2008-01-01

    point scale evaluate the sentence from the point of view of the post-editor. The post-editor profile defined by the LSP is based on the experiences of introducing MT in the LSP workflow. The relation between the Translation Edit Rate (TER) scores and “Usability” scores is tested. We find TER a candidate...... for an automatic metric simulating the post-editors’ usability judgements. LSP tests show 67% saved time in post-editing for the tested domain. Finally, the use of weighted sub-domain phrase tables in a SMT system is shown to improve translation quality....

  1. Domain Discretization and Circle Packings

    DEFF Research Database (Denmark)

    Dias, Kealey

    , and the edges are geodesic segments (Euclidean, hyperbolic, or spherical) connecting centers of circles that are tangent to each other. Three circles that are mutually tangent form a face of the triangulation. Since circle packing is closely related to triangulation, circle packing methods can be applied...... to domain discretization problems such as triangulation and unstructured mesh generation techniques. We wish to ask ourselves the question: given a cloud of points in the plane (we restrict ourselves to planar domains), is it possible to construct a circle packing preserving the positions of the vertices...

  2. Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.

    Directory of Open Access Journals (Sweden)

    Wei Deng

    Full Text Available Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear. Basing on a solution structure of calcium-loaded calmodulin in complex with a L-selectin fragment that contains a portion of its transmembrane domain, Gifford et al. (University of Calgary recently suggested that calmodulin regulates L-selectin shedding by binding directly to a portion of the L-selectin transmembrane domain in a compact conformation. Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner. Calmodulin adopts a similarly extended conformation in a ternary complex with the N-terminal FERM domain of moesin and CLS reconstituted in the phospholipid liposome that mimics the native membrane environment. These results indicate that calmodulin does not bind directly to the transmembrane domain of L-selectin. Understanding the association of calmodulin with L-selectin helps to shed light on the mechanisms underlying regulation of ectodomain shedding.

  3. Multi-domain service dispatching scheme based on SDON virtualized network

    Science.gov (United States)

    Zheng, Mingfang; Li, Hui; Ji, Yuefeng

    2017-10-01

    With the information flow in the network growing rapidly and the size of network extending gradually, it is essential that SDON networking supports multi-domain optical services. Since the type of network has moved toward complicated and converged, the disparate network resource has interlaced, an isomerized network situation is the trend in the future. Accordingly, end-to-end (E2E) services have shifted from a single service provider domain towards a multi-domain service provider. On this condition, the traditional isolated networking mode is so difficult to meet the current demand. E2E multi-domain services are the trend in the future. This paper proposes a multi-domain service dispatching scheme based on SDON virtualized network. By sending concurrent http requests to controller multiple single-domain controllers, web service management will manage optical devices and achieve E2E multi-domain service requests over this scheme. The management layer establishes E2E services dispatching system in multi-domain virtual optical network and it changes the present situation of disparate single service provider incompatibility. The experiment also indicates the reality possibility of the multi-domain dispatching scheme. This scheme will provide basis for the large scale multi-domain networking based on SDON in the future.

  4. Improving the performance of DomainDiscovery of protein domain boundary assignment using inter-domain linker index

    Directory of Open Access Journals (Sweden)

    Zomaya Albert Y

    2006-12-01

    Full Text Available Abstract Background Knowledge of protein domain boundaries is critical for the characterisation and understanding of protein function. The ability to identify domains without the knowledge of the structure – by using sequence information only – is an essential step in many types of protein analyses. In this present study, we demonstrate that the performance of DomainDiscovery is improved significantly by including the inter-domain linker index value for domain identification from sequence-based information. Improved DomainDiscovery uses a Support Vector Machine (SVM approach and a unique training dataset built on the principle of consensus among experts in defining domains in protein structure. The SVM was trained using a PSSM (Position Specific Scoring Matrix, secondary structure, solvent accessibility information and inter-domain linker index to detect possible domain boundaries for a target sequence. Results Improved DomainDiscovery is compared with other methods by benchmarking against a structurally non-redundant dataset and also CASP5 targets. Improved DomainDiscovery achieves 70% accuracy for domain boundary identification in multi-domains proteins. Conclusion Improved DomainDiscovery compares favourably to the performance of other methods and excels in the identification of domain boundaries for multi-domain proteins as a result of introducing support vector machine with benchmark_2 dataset.

  5. Extended cycle hormonal contraception in adolescents.

    Science.gov (United States)

    Sucato, Gina S; Gerschultz, Kelly L

    2005-10-01

    There is increasing interest in the use of extended cycles of hormonal contraception to manage menstrual cycle-related complaints in adolescents and to accommodate the menstrual preferences of patients using hormonal contraception. This review summarizes recent findings related to the use of extended cycles and highlights their relevance to adolescents. Many adolescents would prefer to menstruate less frequently. Among health care providers who prescribe hormonal contraceptives, the majority believe suppressing withdrawal bleeding is well tolerated and prescribe extended cycling regimens to their patients. Shortening or eliminating the hormone-free interval results in greater ovarian suppression and thus may increase contraceptive efficacy. Studies in adult women have not identified changes in metabolic parameters beyond what would be expected from traditional cyclic use. New endometrial biopsy data have found no pathologic changes; most women using an extended cycle had atrophic endometriums. Extended cycling is frequently associated with breakthrough bleeding. In some women, this can be managed with a brief hormone-free interval. Recent findings demonstrate high levels of interest in extended cycling among adolescents and providers, and continue to add to the growing body of literature supporting the safety and improved contraceptive efficacy of extended regimens. Further research is warranted to focus on issues including cancer, thrombotic disease and fertility, and should enroll a sufficient adolescent sample.

  6. Modeling the Extended Warranty: A Managerial Focus

    OpenAIRE

    Myung, Noah; Eger, Robert J.

    2015-01-01

    We provide a model of an extended warranty. To maximize profit, a producer always wants to sell with some type of warranty as opposed to selling with no warranty. The extended warranty is more likely to be provided as the consumer becomes more patient, as the producer becomes impatient, or if the likelihood of product failure does not increase too much in the extended period. We show that there is a separating equilibrium in which the high quality producers sell with warranties and the low qu...

  7. Extended Hamiltonian approach to continuous tempering.

    Science.gov (United States)

    Gobbo, Gianpaolo; Leimkuhler, Benedict J

    2015-06-01

    We introduce an enhanced sampling simulation technique based on continuous tempering, i.e., on continuously varying the temperature of the system under investigation. Our approach is mathematically straightforward, being based on an extended Hamiltonian formulation in which an auxiliary degree of freedom, determining the effective temperature, is coupled to the physical system. The physical system and its temperature evolve continuously in time according to the equations of motion derived from the extended Hamiltonian. Due to the Hamiltonian structure, it is easy to show that a particular subset of the configurations of the extended system is distributed according to the canonical ensemble for the physical system at the correct physical temperature.

  8. Overlap/Domain-wall reweighting

    Science.gov (United States)

    Fukaya, H.; Aoki, S.; Cossu, G.; Hashimoto, S.; Kaneko, T.; Noaki, J.

    We investigate the eigenvalues of nearly chiral lattice Dirac operators constructed with five-dimensional implementations. Allowing small violation of the Ginsparg-Wilson relation, the HMC simulation is made much faster while the eigenvalues are not significantly affected. We discuss the possibility of reweighting the gauge configurations generated with domain-wall fermions to those of exactly chiral lattice fermions.

  9. Life sciences domain analysis model.

    Science.gov (United States)

    Freimuth, Robert R; Freund, Elaine T; Schick, Lisa; Sharma, Mukesh K; Stafford, Grace A; Suzek, Baris E; Hernandez, Joyce; Hipp, Jason; Kelley, Jenny M; Rokicki, Konrad; Pan, Sue; Buckler, Andrew; Stokes, Todd H; Fernandez, Anna; Fore, Ian; Buetow, Kenneth H; Klemm, Juli D

    2012-01-01

    Meaningful exchange of information is a fundamental challenge in collaborative biomedical research. To help address this, the authors developed the Life Sciences Domain Analysis Model (LS DAM), an information model that provides a framework for communication among domain experts and technical teams developing information systems to support biomedical research. The LS DAM is harmonized with the Biomedical Research Integrated Domain Group (BRIDG) model of protocol-driven clinical research. Together, these models can facilitate data exchange for translational research. The content of the LS DAM was driven by analysis of life sciences and translational research scenarios and the concepts in the model are derived from existing information models, reference models and data exchange formats. The model is represented in the Unified Modeling Language and uses ISO 21090 data types. The LS DAM v2.2.1 is comprised of 130 classes and covers several core areas including Experiment, Molecular Biology, Molecular Databases and Specimen. Nearly half of these classes originate from the BRIDG model, emphasizing the semantic harmonization between these models. Validation of the LS DAM against independently derived information models, research scenarios and reference databases supports its general applicability to represent life sciences research. The LS DAM provides unambiguous definitions for concepts required to describe life sciences research. The processes established to achieve consensus among domain experts will be applied in future iterations and may be broadly applicable to other standardization efforts. The LS DAM provides common semantics for life sciences research. Through harmonization with BRIDG, it promotes interoperability in translational science.

  10. Frequency-Domain Transient Imaging.

    Science.gov (United States)

    Jingyu Lin; Yebin Liu; Jinli Suo; Qionghai Dai

    2017-05-01

    A transient image is the optical impulse response of a scene, which also visualizes the propagation of light during an ultra-short time interval. In contrast to the previous transient imaging which samples in the time domain using an ultra-fast imaging system, this paper proposes transient imaging in the frequency domain using a multi-frequency time-of-flight (ToF) camera. Our analysis reveals the Fourier relationship between transient images and the measurements of a multi-frequency ToF camera, and identifies the causes of the systematic error-non-sinusoidal and frequency-varying waveforms and limited frequency range of the modulation signal. Based on the analysis we propose a novel framework of frequency-domain transient imaging. By removing the systematic error and exploiting the harmonic components inside the measurements, we achieves high quality reconstruction results. Moreover, our technique significantly reduces the computational cost of ToF camera based transient image reconstruction, especially reduces the memory usage, such that it is feasible for the reconstruction of transient images at extremely small time steps. The effectiveness of frequency-domain transient imaging is tested on synthetic data, real data from the web, and real data acquired by our prototype camera.

  11. The Distributed-SDF Domain

    DEFF Research Database (Denmark)

    Cuadrado, Daniel Lázaro; Ravn, Anders Peter; Koch, Peter

    2005-01-01

    . Those relations are in charge of receiving the tokens and placing them at the right receiver. The same goes for the output ports. Tokens are sent over the net to the distributed processes that are expecting to receive them. The distributed-SDF domain provides certain advantages derived from its...

  12. Modules over discrete valuation domains

    CERN Document Server

    Tuganbaev, Askar A

    2008-01-01

    This book provides the first systematic treatment of modules over discrete valuation domains which plays an important role in various areas of algebra, especially in commutative algebra. Many important results representing the state of the art are presented in the text which is supplemented by exercises and interesting open problems. An important contribution to commutative algebra.

  13. ESG: extended similarity group method for automated protein function prediction.

    Science.gov (United States)

    Chitale, Meghana; Hawkins, Troy; Park, Changsoon; Kihara, Daisuke

    2009-07-15

    Importance of accurate automatic protein function prediction is ever increasing in the face of a large number of newly sequenced genomes and proteomics data that are awaiting biological interpretation. Conventional methods have focused on high sequence similarity-based annotation transfer which relies on the concept of homology. However, many cases have been reported that simple transfer of function from top hits of a homology search causes erroneous annotation. New methods are required to handle the sequence similarity in a more robust way to combine together signals from strongly and weakly similar proteins for effectively predicting function for unknown proteins with high reliability. We present the extended similarity group (ESG) method, which performs iterative sequence database searches and annotates a query sequence with Gene Ontology terms. Each annotation is assigned with probability based on its relative similarity score with the multiple-level neighbors in the protein similarity graph. We will depict how the statistical framework of ESG improves the prediction accuracy by iteratively taking into account the neighborhood of query protein in the sequence similarity space. ESG outperforms conventional PSI-BLAST and the protein function prediction (PFP) algorithm. It is found that the iterative search is effective in capturing multiple-domains in a query protein, enabling accurately predicting several functions which originate from different domains. ESG web server is available for automated protein function prediction at http://dragon.bio.purdue.edu/ESG/.

  14. Compiling Dictionaries Using Semantic Domains*

    Directory of Open Access Journals (Sweden)

    Ronald Moe

    2011-10-01

    Full Text Available

    Abstract: The task of providing dictionaries for all the world's languages is prodigious, re-quiring efficient techniques. The text corpus method cannot be used for minority languages lacking texts. To meet the need, the author has constructed a list of 1 600 semantic domains, which he has successfully used to collect words. In a workshop setting, a group of speakers can collect as many as 17 000 words in ten days. This method results in a classified word list that can be efficiently expanded into a full dictionary. The method works because the mental lexicon is a giant web or-ganized around key concepts. A semantic domain can be defined as an important concept together with the words directly related to it by lexical relations. A person can utilize the mental web to quickly jump from word to word within a domain. The author is developing a template for each domain to aid in collecting words and in de-scribing their semantics. Investigating semantics within the context of a domain yields many in-sights. The method permits the production of both alphabetically and semantically organized dic-tionaries. The list of domains is intended to be universal in scope and applicability. Perhaps due to universals of human experience and universals of linguistic competence, there are striking simi-larities in various lists of semantic domains developed for languages around the world. Using a standardized list of domains to classify multiple dictionaries opens up possibilities for cross-lin-guistic research into semantic and lexical universals.

    Keywords: SEMANTIC DOMAINS, SEMANTIC FIELDS, SEMANTIC CATEGORIES, LEX-ICAL RELATIONS, SEMANTIC PRIMITIVES, DOMAIN TEMPLATES, MENTAL LEXICON, SEMANTIC UNIVERSALS, MINORITY LANGUAGES, LEXICOGRAPHY

    Opsomming: Samestelling van woordeboeke deur gebruikmaking van se-mantiese domeine. Die taak van die voorsiening van woordeboeke aan al die tale van die wêreld is geweldig en vereis doeltreffende tegnieke. Die

  15. Baryogenesis in extended inflation. Part 1: Baryogenesis via production and decay of supermassive bosons

    Energy Technology Data Exchange (ETDEWEB)

    Barrow, J.D.; Copeland, E.J.; Kolb, E.W.; Liddle, A.R.

    1990-05-01

    Baryogenesis occurring during the thermalization stage at the end of extended inflation is considered. In extended inflation, the Universe passes through a first-order phase transition via bubble nucleation; inflation comes to an end when bubbles collide and their collisions convert energy stored in the bubble walls into particles. This naturally provides conditions well out of thermal equilibrium in which baryon number violating processes may proceed; the amount of baryon asymmetry which may be produced this way is estimated. The avoidance of a monopole or domain wall problem can also be ensured and isothermal density perturbations may arise as a remnant of spatial variation in the baryon asymmetry.

  16. Baryogenesis in extended inflation. I. Baryogenesis via production and decay of supermassive bosons

    Energy Technology Data Exchange (ETDEWEB)

    Barrow, J.D.; Copeland, E.J. (Division of Physics and Astronomy, University of Sussex, Brighton BN1 9QH United Kingdom (GB)); Kolb, E.W. (NASA/Fermilab Astrophysics Center, Fermi National Accelerator Laboratory, Batavia, Illinois 60510-0500 (USA) Department of Astronomy and Astrophysics, Enrico Fermi Institute, The University of Chicago, Chicago, Illinois 60637 (USA)); Liddle, A.R. (Division of Physics and Astronomy, University of Sussex, Brighton (United Kingdom))

    1991-02-15

    We consider baryogenesis occurring during the thermalization stage at the end of extended inflation. In extended inflation, the Universe passes through a first-order phase transition via bubble nucleation; inflation comes to an end when bubbles collide and their collisions convert energy stored in the bubble walls into particles. This naturally provides conditions well out of thermal equilibrium in which baryon-number-violating processes may proceed; we estimate the amount of baryon asymmetry which may be produced this way. The avoidance of a monopole or domain-wall problem can also be ensured and isothermal density perturbations may arise as a remnant of spatial variation in the baryon asymmetry.

  17. Domain relaxation in Langmuir films

    Science.gov (United States)

    Alexander, James C.; Bernoff, Andrew J.; Mann, Elizabeth K.; Mann, J. Adin; Wintersmith, Jacob R.; Zou, Lu

    We report on theoretical studies of molecularly thin Langmuir films on the surface of a quiescent subfluid and qualitatively compare the results to both new and previous experiments. The film covers the entire fluid surface, but domains of different phases are observed. In the absence of external forcing, the compact domains tend to relax to circles, driven by a line tension at the phase boundaries. When stretched (by a transient applied stagnation-point flow or by stirring), a compact domain elongates, creating a bola consisting of two roughly circular reservoirs connected by a thin tether. This shape will then relax slowly to the minimum-energy configuration of a circular domain. The tether is never observed to rupture, even when it is more than a hundred times as long as it is wide. We model these experiments by taking previous descriptions of the full hydrodynamics, identifying the dominant effects via dimensional analysis, and reducing the system to a more tractable form. The result is a free boundary problem for an inviscid Langmuir film whose motion is driven by the line tension of the domain and damped by the viscosity of the subfluid. Using this model we derive relaxation rates for perturbations of a uniform strip and a circular patch. We also derive a boundary integral formulation which allows an efficient numerical solution of the problem. Numerically this model replicates the formation of a bola and the subsequent relaxation observed in the experiments. Finally, we suggest physical properties of the system (such as line tension) that can be deduced by comparison of the theory and numerical simulations to the experiment. Two movies are available with the online version of the paper.

  18. Domains of Awareness in Schizophrenia

    Science.gov (United States)

    Gilleen, J.; Greenwood, K.; David, A. S.

    2011-01-01

    Patients with schizophrenia are often characterized as lacking insight or awareness into their illness and symptoms, yet despite considerable research, we still lack a full understanding of the factors involved in causing poor awareness. Within schizophrenia, there has been shown to be a fractionation across dimensions of awareness into mental illness: of being ill, of symptoms, and of treatment compliance. Recently, attention has turned to evidence of a fractionation between awareness of illness and of cognitive impairments and functioning. The current study investigated the degree of fractionation across a broad range of domains of function in schizophrenia and how each domain may be associated with neuropsychological functioning, clinical, mood, and demographic variables. Thirty-one mostly chronic stable patients with schizophrenia completed a battery of neuropsychological tests and measures of psychopathology, including mood. Cognitive insight and awareness of illness, symptoms, memory, and behavioral functioning were also measured. Insight and awareness were assessed using a combination of semistructured interview, observer-rated, self-rated, and objective measures, and included measures of the discrepancy between carer and self-ratings of impairment. Results revealed that awareness of functioning in each domain was largely independent and that awareness in each domain was predicted by different factors. Insight into symptoms was relatively poor while insight into cognitive deficits was preserved. Relative to neuropsychological variables, cognitive insight, comprising self-certainty and self-reflexivity, was a greater predictor of awareness. In conclusion, awareness is multiply fractionated and multiply determined. Therapeutic interventions could, therefore, produce beneficial changes within specific domains of awareness. PMID:20851850

  19. Inferring domain-domain interactions from protein-protein interactions with formal concept analysis.

    Directory of Open Access Journals (Sweden)

    Susan Khor

    Full Text Available Identifying reliable domain-domain interactions will increase our ability to predict novel protein-protein interactions, to unravel interactions in protein complexes, and thus gain more information about the function and behavior of genes. One of the challenges of identifying reliable domain-domain interactions is domain promiscuity. Promiscuous domains are domains that can occur in many domain architectures and are therefore found in many proteins. This becomes a problem for a method where the score of a domain-pair is the ratio between observed and expected frequencies because the protein-protein interaction network is sparse. As such, many protein-pairs will be non-interacting and domain-pairs with promiscuous domains will be penalized. This domain promiscuity challenge to the problem of inferring reliable domain-domain interactions from protein-protein interactions has been recognized, and a number of work-arounds have been proposed. This paper reports on an application of Formal Concept Analysis to this problem. It is found that the relationship between formal concepts provides a natural way for rare domains to elevate the rank of promiscuous domain-pairs and enrich highly ranked domain-pairs with reliable domain-domain interactions. This piggybacking of promiscuous domain-pairs onto less promiscuous domain-pairs is possible only with concept lattices whose attribute-labels are not reduced and is enhanced by the presence of proteins that comprise both promiscuous and rare domains.

  20. Generalized Laplace Transforms and Extended Heaviside Calculus

    Science.gov (United States)

    Deakin, Michael A. B.

    2008-01-01

    An extended Heaviside calculus proposed by Peraire in a recent paper is similar to a generalization of the Laplace transform proposed by the present author. This similarity will be illustrated by analysis of an example supplied by Peraire.

  1. Extended Adjuvant Therapy for Breast Cancer

    Science.gov (United States)

    An NCI Cancer Currents blog on findings from a recent clinical trial which showed that extending adjuvant therapy with an aromatase inhibitor can have important benefits for some women with early-stage cancer.

  2. PREVALENCE OF EXTENDED SPECTRUM β-LACTAMASES ...

    African Journals Online (AJOL)

    DR. AMINU

    ABSTRACT. Confirmed variants of enterobacteriaceae isolated from 143 patients that attended Murtala. Mohammed Specialist Hospital Kano, were screened for extended spectrum β-lactamases (ESBLs) production using Clinical Laboratory Standards Institute (CLSI) breakpoint. Suspected ESBLs producers were ...

  3. Large exchange-dominated domain wall velocities in antiferromagnetically coupled nanowires

    Directory of Open Access Journals (Sweden)

    Majd Kuteifan

    2016-04-01

    Full Text Available Magnetic nanowires supporting field- and current-driven domain wall motion are envisioned for methods of information storage and processing. A major obstacle for their practical use is the domain-wall velocity, which is traditionally limited for low fields and currents due to the Walker breakdown occurring when the driving component reaches a critical threshold value. We show through numerical and analytical modeling that the Walker breakdown limit can be extended or completely eliminated in antiferromagnetically coupled magnetic nanowires. These coupled nanowires allow for large domain-wall velocities driven by field and/or current as compared to conventional nanowires.

  4. Time-domain Green's Function Method for three-dimensional nonlinear subsonic flows

    Science.gov (United States)

    Tseng, K.; Morino, L.

    1978-01-01

    The Green's Function Method for linearized 3D unsteady potential flow (embedded in the computer code SOUSSA P) is extended to include the time-domain analysis as well as the nonlinear term retained in the transonic small disturbance equation. The differential-delay equations in time, as obtained by applying the Green's Function Method (in a generalized sense) and the finite-element technique to the transonic equation, are solved directly in the time domain. Comparisons are made with both linearized frequency-domain calculations and existing nonlinear results.

  5. Some Aspects of Extended Kinetic Equation

    Directory of Open Access Journals (Sweden)

    Dilip Kumar

    2015-09-01

    Full Text Available Motivated by the pathway model of Mathai introduced in 2005 [Linear Algebra and Its Applications, 396, 317–328] we extend the standard kinetic equations. Connection of the extended kinetic equation with fractional calculus operator is established. The solution of the general form of the fractional kinetic equation is obtained through Laplace transform. The results for the standard kinetic equation are obtained as the limiting case.

  6. Musical Manipulations and the Emotionally Extended Mind

    Directory of Open Access Journals (Sweden)

    Joel Krueger

    2015-05-01

    Full Text Available I respond to Kersten's criticism in his article "Music and Cognitive Extension" of my approach to the musically extended emotional mind in Krueger (2014. I specify how we manipulate—and in so doing, integrate with—music when, as active listeners, we become part of a musically extended cognitive system. I also indicate how Kersten's account might be enriched by paying closer attention to the way that music functions as an environmental artifact for emotion regulation.

  7. Extended Dislocations in Plastically Deformed Metallic Nanoparticles

    OpenAIRE

    Bin Zheng; Yi-Nong Wang; Min Qi; Huiling Du

    2016-01-01

    In the present study, the sawtooth nature of compressive loading of metallic nanoparticles is observed using a molecular dynamics simulation. The atomic structure evolution confirmed that extended dislocations are the main defects split into two asynchronous partial disloca‐ tions, along with stored and released fault energy. This is considered the essence of sawtooth loading. The size of the nanoparticles relative to the equilibrium width of the extended dislocation is discussed to explain t...

  8. Extended Dislocations in Plastically Deformed Metallic Nanoparticles

    Directory of Open Access Journals (Sweden)

    Bin Zheng

    2016-05-01

    Full Text Available In the present study, the sawtooth nature of compressive loading of metallic nanoparticles is observed using a molecular dynamics simulation. The atomic structure evolution confirmed that extended dislocations are the main defects split into two asynchronous partial disloca‐ tions, along with stored and released fault energy. This is considered the essence of sawtooth loading. The size of the nanoparticles relative to the equilibrium width of the extended dislocation is discussed to explain the simulation results.

  9. IMPLICATIONS OF CROSS DOMAIN FIRES IN MULTI-DOMAIN BATTLE

    Science.gov (United States)

    2017-04-06

    dimension of the battlefield. Where once the battlefield was objective’s based, it is now based on area control and is no longer restricted to the...Other adversaries like Russia are investing in research and development in fields such as directed energy weapons, rail guns , radio frequency weapons...advantage and control key terrain to consolidate gains.”12 Multi-Domain Battle integrates joint, interorganizational and multinational capabilities

  10. Extended Access List untuk Mengendalikan Trafik Jaringan

    Directory of Open Access Journals (Sweden)

    Hari Antoni Musril

    2016-12-01

    Full Text Available Keamana jaringan komputer saat ini menjadi hal penting untuk diterapkan. Banyak organisasi yang telah menjadikan teknologi informasi sebagai bahagian penting dalam menunjang aktivitasnya. Akses pengguna yang tidak dibatasi menjadi ancaman bagi sebuah organisasi, karena banyak data dan informasi penting yang tersebar dalam perangkat jaringan komputer di organisasi tersebut dapat disusupi oleh pihak yang tidak berwenang. Salah satu usaha yang dapat dilakukan adalah dengan menerapkan extended access list yang merupakan salah satu bagian dari metode access control list. Extended access list dapat menyaring lalu lintas data suatu jaringan dengan mengontrol apakah paket-paket tersebut dilewatkan atau dihentikan. Extended access list juga dapat menjamin keamanan untuk setiap komputer sehingga jalur komunikasi serta hak akses setiap komputer dapat berjalan dengan baik. Extended access list memungkinkan penyaringan berdasarkan sumber atau alamat tujuan, protokol yang dipilih, port yang digunakan, dan apakah koneksi sudah ditetapkan. Tulisan ini membahas penerapan extended access list dalam jaringan supaya dapat melakukan filter terhadap paket data yang melewati jaringan. Penerapannya menggunakan software Packet Tracer 6.1.1 untuk membuat prototipe jaringan dan mensimulasikannya. Sehingga nanti dapat diterapkan pada jaringan yang sebenarnya. List yang dibangun pada penelitian ini diterapkan untuk protokol antara lain : TCP (WWW, FTP, Telnet, SMTP, POP3, UDP (DNS, dan ICMP (Ping. Hasilnya didapatkan extended access list yang dikonfigurasi pada router dalam topologi penelitian ini mampu melakukan filter terhadap paket yang melewati jaringan. Hasil konfigurasinya sangat spesifik, sehingga penerapan hak akses permit dan deny dapat dilakukan sesuai dengan aturan dan skenario yang dirancang.

  11. Statistical Mechanics of Time Domain Ensemble Learning

    OpenAIRE

    Miyoshi, Seiji; Uezu, Tatsuya; Okada, Masato

    2006-01-01

    Conventional ensemble learning combines students in the space domain. On the other hand, in this paper we combine students in the time domain and call it time domain ensemble learning. In this paper, we analyze the generalization performance of time domain ensemble learning in the framework of online learning using a statistical mechanical method. We treat a model in which both the teacher and the student are linear perceptrons with noises. Time domain ensemble learning is twice as effective ...

  12. Minimum-domain impulse theory for unsteady aerodynamic force

    Science.gov (United States)

    Kang, L. L.; Liu, L. Q.; Su, W. D.; Wu, J. Z.

    2018-01-01

    We extend the impulse theory for unsteady aerodynamics from its classic global form to finite-domain formulation then to minimum-domain form and from incompressible to compressible flows. For incompressible flow, the minimum-domain impulse theory raises the finding of Li and Lu ["Force and power of flapping plates in a fluid," J. Fluid Mech. 712, 598-613 (2012)] to a theorem: The entire force with discrete wake is completely determined by only the time rate of impulse of those vortical structures still connecting to the body, along with the Lamb-vector integral thereof that captures the contribution of all the rest disconnected vortical structures. For compressible flows, we find that the global form in terms of the curl of momentum ∇ × (ρu), obtained by Huang [Unsteady Vortical Aerodynamics (Shanghai Jiaotong University Press, 1994)], can be generalized to having an arbitrary finite domain, but the formula is cumbersome and in general ∇ × (ρu) no longer has discrete structures and hence no minimum-domain theory exists. Nevertheless, as the measure of transverse process only, the unsteady field of vorticity ω or ρω may still have a discrete wake. This leads to a minimum-domain compressible vorticity-moment theory in terms of ρω (but it is beyond the classic concept of impulse). These new findings and applications have been confirmed by our numerical experiments. The results not only open an avenue to combine the theory with computation-experiment in wide applications but also reveal a physical truth that it is no longer necessary to account for all wake vortical structures in computing the force and moment.

  13. Page 1 INDIAN SILICIFIED PLANTS I. Azolla intertrappea Sah ...

    Indian Academy of Sciences (India)

    in the Deccan the fossils are preserved in lenticles of fresh-water sediments interbedded with volcanic lavas which must have been poured out inter- mittently. The fine state of preservation of the plants in both the areas is probably due to their having been suddenly overwhelmed by showers of volcanic ash or by the acid ...

  14. Aquaculture en zone sahélo-soudanienne: diagnostic des ...

    African Journals Online (AJOL)

    SARAH

    30 avr. 2014 ... Journal of Applied Biosciences 76:6368– 6385 .... communautaire (en vert) ; les régions du Centre-nord, du Centre-est, et de la Boucle du .... contraintes au développement de la pisciculture. ..... pour le producteur car plusieurs facteurs climatiques ... côtiers (Sénégal, Ghana, Bénin par exemple) (FAO,.

  15. Aquaculture en zone sahélo-soudanienne: diagnostic des ...

    African Journals Online (AJOL)

    SARAH

    30 avr. 2014 ... (Q1 : Administration et personnel technique du projet,. Q2 : chefs de village et CVD, Q3 : Membres des comités de gestion, Q4 : Aquaculteurs non membres des comités de gestion et Q5 : Acteurs non aquaculteurs). Ces fichiers obtenus en EpiData ont été transférés à l'aide de StatTransfer dans le logiciel.

  16. Domain wall assisted GMR head with spin-Hall effect

    Energy Technology Data Exchange (ETDEWEB)

    Arun, R., E-mail: arunbdu@gmail.com [Centre for Nonlinear Dynamics, School of Physics, Bharathidasan University, Tiruchirappalli - 620 024 (India); Sabareesan, P., E-mail: sendtosabari@gmail.com [Centre for Nonlinear Science and Engineering, School of Electrical and Electronics Engineering, SASTRA University, Thanjavur - 613 401 (India); Daniel, M., E-mail: danielcnld@gmail.com [Centre for Nonlinear Dynamics, School of Physics, Bharathidasan University, Tiruchirappalli - 620 024 (India); SNS Institutions, Coimbatore - 641 049, Tamilnadu (India)

    2016-05-06

    We theoretically study the dynamics of a field induced domain wall in the Py/Pt bi-layer structure in the presence of spin-Hall effect (SHE) by solving the Landau-Lifshitz-Gilbert (LLG) equation along with the adiabatic, nonadiabatic and SHE spin-transfer torques (STTs). It is observed that a weak magnetic field moves the domain wall with high velocity in the presence of SHE and the direction of the velocity is changed by changing the direction of the weak field. The numerical results show that the magnetization of the ferromagnetic layer can be reversed quickly through domain wall motion by changing the direction of a weak external field in the presence of SHE while the direction of current is fixed. The SHE reduces the magnetization reversal time of 1000 nm length strip by 14.7 ns. This study is extended to model a domain wall based GMR (Giant Magnetoresistance) read head with SHE.

  17. Ubiquitin domain proteins in disease

    Directory of Open Access Journals (Sweden)

    Hartmann-Petersen Rasmus

    2007-11-01

    Full Text Available Abstract The human genome encodes several ubiquitin-like (UBL domain proteins (UDPs. Members of this protein family are involved in a variety of cellular functions and many are connected to the ubiquitin proteasome system, an essential pathway for protein degradation in eukaryotic cells. Despite their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com.

  18. Gabor domain optical coherence microscopy

    Science.gov (United States)

    Murali, Supraja

    Time domain Optical Coherence Tomography (TD-OCT), first reported in 1991, makes use of the low temporal coherence properties of a NIR broadband laser to create depth sectioning of up to 2mm under the surface using optical interferometry and point to point scanning. Prior and ongoing work in OCT in the research community has concentrated on improving axial resolution through the development of broadband sources and speed of image acquisition through new techniques such as Spectral domain OCT (SD-OCT). In SD-OCT, an entire depth scan is acquired at once with a low numerical aperture (NA) objective lens focused at a fixed point within the sample. In this imaging geometry, a longer depth of focus is achieved at the expense of lateral resolution, which is typically limited to 10 to 20 mum. Optical Coherence Microscopy (OCM), introduced in 1994, combined the advantages of high axial resolution obtained in OCT with high lateral resolution obtained by increasing the NA of the microscope placed in the sample arm. However, OCM presented trade-offs caused by the inverse quadratic relationship between the NA and the DOF of the optics used. For applications requiring high lateral resolution, such as cancer diagnostics, several solutions have been proposed including the periodic manual re-focusing of the objective lens in the time domain as well as the spectral domain C-mode configuration in order to overcome the loss in lateral resolution outside the DOF. In this research, we report for the first time, high speed, sub-cellular imaging (lateral resolution of 2 mum) in OCM using a Gabor domain image processing algorithm with a custom designed and fabricated dynamic focus microscope interfaced to a Ti:Sa femtosecond laser centered at 800 nm within an SD-OCM configuration. It is envisioned that this technology will provide a non-invasive replacement for the current practice of multiple biopsies for skin cancer diagnosis. The research reported here presents three important advances

  19. MPEG-2 Compressed-Domain Algorithms for Video Analysis

    Directory of Open Access Journals (Sweden)

    Hesseler Wolfgang

    2006-01-01

    Full Text Available This paper presents new algorithms for extracting metadata from video sequences in the MPEG-2 compressed domain. Three algorithms for efficient low-level metadata extraction in preprocessing stages are described. The first algorithm detects camera motion using the motion vector field of an MPEG-2 video. The second method extends the idea of motion detection to a limited region of interest, yielding an efficient algorithm to track objects inside video sequences. The third algorithm performs a cut detection using macroblock types and motion vectors.

  20. C2-domain containing calcium sensors in neuroendocrine secretion

    DEFF Research Database (Denmark)

    Pinheiro, Paulo S; Houy, Sébastien; Sørensen, Jakob B

    2016-01-01

    to calcium, trigger the merger of cargo-filled vesicles with the plasma membrane. Low-affinity, fast-kinetics calcium sensors of the synaptotagmin family - especially synaptotagmin-1 and synaptotagmin-2 - are the main calcium sensors for fast exocytosis triggering in many cell types. Their functions extend...... the properties and possible interplay of (some of) the major C2-domain containing calcium sensors in calcium-triggered exocytosis. This article is part of a mini review series: "Synaptic Function and Dysfunction in Brain Diseases"....

  1. Fast Convolutional Sparse Coding in the Dual Domain

    KAUST Repository

    Affara, Lama Ahmed

    2017-09-27

    Convolutional sparse coding (CSC) is an important building block of many computer vision applications ranging from image and video compression to deep learning. We present two contributions to the state of the art in CSC. First, we significantly speed up the computation by proposing a new optimization framework that tackles the problem in the dual domain. Second, we extend the original formulation to higher dimensions in order to process a wider range of inputs, such as color inputs, or HOG features. Our results show a significant speedup compared to the current state of the art in CSC.

  2. Domains of bosonic functional integrals

    Energy Technology Data Exchange (ETDEWEB)

    Botelho, Luiz C.L. [Universidade Federal Rural do Rio de Janeiro, RJ (Brazil). Dept. de Fisica]|[Para Univ., Belem, PA (Brazil). Dept. de Fisica

    1998-07-01

    We propose a mathematical framework for bosonic Euclidean quantum field functional integrals based on the theory of integration on the dual algebraic vector space of classical field sources. We present a generalization of the Minlos-Dao Xing theorem and apply it to determine exactly the domain of integration associated to the functional integral representation of the two-dimensional quantum electrodynamics Schwinger generating functional. (author)

  3. Categorization in the Affective Domain

    DEFF Research Database (Denmark)

    Sauciuc, Gabriela-Alina

    2011-01-01

    Data collected in Romance and Scandinavian languages (N=474) in a superordinate category name production task indicate that a multiple-strategy approach would be more suitable for accounting of categorization in the affective domain instead of a prototype approach as suggested by previous studies....... This paper will highlight performance aspects which appear to be consistent with such an interpretation, as well as an important layman- expert knowledge asymmetry in affective categorization....

  4. Ubiquitin domain proteins in disease

    DEFF Research Database (Denmark)

    Klausen, Louise Kjær; Schulze, Andrea; Seeger, Michael

    2007-01-01

    their structural similarity, the UBL domains appear to have a range of different targets, resulting in a considerable diversity with respect to UDP function. Here, we give a short summary of the biochemical and physiological roles of the UDPs, which have been linked to human diseases including neurodegeneration...... and cancer. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)....

  5. Superconductivity in domains with corners

    DEFF Research Database (Denmark)

    Bonnaillie-Noel, Virginie; Fournais, Søren

    2007-01-01

    We study the two-dimensional Ginzburg-Landau functional in a domain with corners for exterior magnetic field strengths near the critical field where the transition from the superconducting to the normal state occurs. We discuss and clarify the definition of this field and obtain a complete...... asymptotic expansion for it in the large $\\kappa$ regime. Furthermore, we discuss nucleation of superconductivity at the boundary....

  6. A Domain Specific DSP Processor

    OpenAIRE

    Tell, Eric

    2001-01-01

    This thesis describes the design of a domain specific DSP processor. The thesis is divided into two parts. The first part gives some theoretical background, describes the different steps of the design process (both for DSP processors in general and for this project) and motivates the design decisions made for this processor. The second part is a nearly complete design specification. The intended use of the processor is as a platform for hardware acceleration units. Support for this has howe...

  7. [Extended endoscopic endonasal approach to skull base].

    Science.gov (United States)

    López-Arbolay, Omar; González-González, Justo; Rojas-Manresa, Jorge Luis

    2012-11-01

    Different approaches to the skull base have been developed through the sphenoidal sinus. Traditional boundaries of the trans-sphenoidal approach can be extended in antero-posterior and lateral plane. We review our experience with extended endoscopic endonasal approach in 127 cases. We used the extended endoscopic endonasal approach in 127 patients with different lesions of the skull base. This study specifically focuses on: type of lesions, surgical approach, outcome and surgical complications. Extended endoscopic endonasal approach was used in 127 patients with following lesions: 61 invasive adenomas to cavernous sinus, 10 clival chordomas, 21 craniopharyngiomas, 26 meningiomas, 4 cerebrospinal fluid leakages, one meningoencephalocele, 2 malignan lesions and 2 thyroid ophthalmopathy. In tumoral lesions gross total resection was achieved in 82.5%, with better results in craniopharyngiomas 90.5%, followed by invasive adenomas with 85.2%, and meningiomas with 84.6%. The most frequent complications were the insipid (8.6%) diabetes, meningoencefalitis (3.9%) and the hydrocephalic (3.9%). Mortality was 3.9%. The extended endoscopic endonasal approach is a promising minimally invasive alternative for selective cases with skull base lesions. As techniques and technology advance this approach may become the procedure of choice for most lesions and should be considered an option in the management of the patients with these complex pathologies by skull base surgeon. Copyright © 2012 Sociedad Española de Neurocirugía. Published by Elsevier España. All rights reserved.

  8. Modeling extended lactations of dairy cows.

    Science.gov (United States)

    Vargas, B; Koops, W J; Herrero, M; Van Arendonk, J A

    2000-06-01

    Nine mathematical models were compared for their ability to predict daily milk yields (n = 294,986) in standard 305-d and extended lactations of dairy cows of Costa Rica. Lactations were classified by parity (first and later), lactation length (9 to 10, 11 to 12, 13 to 14, 15 to 16, and 16 to 17 mo), and calving to conception interval (1 to 2, 3 to 4, 5 to 6, 7 to 8, and 9 to 10 mo). Of the nine models, the diphasic model and lactation persistency model resulted in the best goodness of fit as measured by adjusted coefficient of determination, residual standard deviation, and Durbin-Watson coefficient. All other models showed less accuracy and positively correlated residuals. In extended lactations, models were also fitted using only test-day records before 305 d, which resulted in a different ranking. The diphasic model showed the best prediction of milk yield in standard and extended lactations. We concluded that the diphasic model provided accurate estimates of milk yield for standard and extended lactations. Interpretation of parameters deserves further attention because of the large variation observed. As expected, the calving to conception interval was found to have a negative effect on milk yield for cows with a standard lactation length. In extended lactations, these negative effects of pregnancy on milk yield were not observed.

  9. KETENTUAN NASAB ANAK SAH, TIDAK SAH, DAN ANAK HASIL TEKNOLOGI REPRODUKSI BUATAN MANUSIA: antara UU Perkawinan dan Fikih Konvensional

    Directory of Open Access Journals (Sweden)

    Afif Muamar

    2016-05-01

    suatu kelanjutan logis atau salah satu produk jadi dari apa yang sering disebut sebagai hukum Islam. Karena itu, peraturan hukum di Indonesia–seperti Undang-undang No. 1 Tahun 1974 tentang Perkawinan dan Kompilasi Hukum Islam (KHI—juga harus menjadi rujukan utama dalam menjawab permasalahan yang bisa saja suatu saat menimbulkan keresahan di masyarakat mengenai kepastian hukumnya.

  10. Domain analysis of computational science - Fifty years of a scientific computing group

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, M.

    2010-02-23

    I employed bibliometric- and historical-methods to study the domain of the Scientific Computing group at Brookhaven National Laboratory (BNL) for an extended period of fifty years, from 1958 to 2007. I noted and confirmed the growing emergence of interdisciplinarity within the group. I also identified a strong, consistent mathematics and physics orientation within it.

  11. The modelling of spatial units (parcels) in the land administration domain model (LADM)

    NARCIS (Netherlands)

    Lemmen, C.H.J.; Van Oosterom, P.J.M.; Thompson, R.J.; Hespanha, J.P.; Uitermark, H.T.

    2010-01-01

    The Land Administration Domain Model (LADM) is under development within the Technical Committee 211 (TC211) of the International Organisation for Standardization (ISO) and identified as ISO 19152. Within the LADM classical cadastral concepts as “parcel” and “boundary” have been extended to be able

  12. Multi-domain, higher order level set scheme for 3D image segmentation on the GPU

    DEFF Research Database (Denmark)

    Sharma, Ojaswa; Zhang, Qin; Anton, François

    2010-01-01

    to evaluate level set surfaces that are $C^2$ continuous, but are slow due to high computational burden. In this paper, we provide a higher order GPU based solver for fast and efficient segmentation of large volumetric images. We also extend the higher order method to multi-domain segmentation. Our streaming...

  13. The Extended Family and Children's Educational Success

    DEFF Research Database (Denmark)

    Jæger, Mads Meier

    2012-01-01

    characteristics of grandparents and aunts and uncles have few direct effects on educational success, resources in the extended family compensate lacking resources in low-SES families, which in turn promote children’s educational success. The main conclusion is that the total effect of family background......Research on family background and educational success focuses almost exclusively on two generations and on parents and children. This paper argues that the extended family makes up a significant part of the total effect of family background on educational success. Empirical results based...... on the Wisconsin Longitudinal Study show that, net of family factors shared by siblings from the same immediate family, factors shared by first cousins from the same extended family account for a nontrivial part of the total variance in children’s educational success. Results also show that while socioeconomic...

  14. Remarkable connections between extended magnetohydrodynamics models

    Energy Technology Data Exchange (ETDEWEB)

    Lingam, M., E-mail: manasvi@physics.utexas.edu; Morrison, P. J., E-mail: morrison@physics.utexas.edu; Miloshevich, G., E-mail: gmilosh@physics.utexas.edu [Department of Physics and Institute for Fusion Studies, The University of Texas at Austin, Austin, Texas 78712 (United States)

    2015-07-15

    Through the use of suitable variable transformations, the commonality of all extended magnetohydrodynamics (MHD) models is established. Remarkable correspondences between the Poisson brackets of inertialess Hall MHD and inertial MHD (which has electron inertia, but not the Hall drift) and extended MHD (which has both effects) are established. The helicities (two in all) for each of these models are obtained through these correspondences. The commonality of all the extended MHD models is traced to the existence of two Lie-dragged 2-forms, which are closely associated with the canonical momenta of the two underlying species. The Lie-dragging of these 2-forms by suitable velocities also leads to the correct equations of motion. The Hall MHD Poisson bracket is analyzed in detail, the Jacobi identity is verified through a detailed proof, and this proof ensures the Jacobi identity for the Poisson brackets of all the models.

  15. Lens-focused transducer modeling using an extended KLM model.

    Science.gov (United States)

    Maréchal, Pierre; Levassort, Franck; Tran-Huu-Hue, Louis-Pascal; Lethiecq, Marc

    2007-05-01

    was performed and found to be in good agreement with such an extension of the KLM model. The experiments confirm the accuracy of such a model in a validity domain up to -12 dB on the pulse-echo voltage within a relative error of 9% between experiment and modeling. This extended KLM model can advantageously be used for other transducer geometries satisfying the assumption of a predominantly longitudinal vibration or in an optimization procedure involving an adequate criteria for a particular application.

  16. Sum rules in extended RPA theories

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, S.; Lipparini, E.

    1988-11-28

    Different moments m/sub k/ of the excitation strength function are studied in the framework of the second RPA and of the extended RPA in which 2p2h correlations are explicitly introduced into the ground state by using first-order perturbation theory. Formal properties of the equations of motion concerning sum rules are derived and compared with those exhibited by the usual 1p1h RPA. The problem of the separation of the spurious solutions in extended RPA calculations is also discussed.

  17. Extended Interneuronal Network of the Dentate Gyrus

    Directory of Open Access Journals (Sweden)

    Gergely G. Szabo

    2017-08-01

    Full Text Available Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.

  18. The extended oloid and its inscribed quadrics

    OpenAIRE

    Bäsel, Uwe; Dirnböck, Hans

    2015-01-01

    The oloid is the convex hull of two circles with equal radius in perpendicular planes so that the center of each circle lies on the other circle. It is part of a developable surface which we call extended oloid. We determine the tangential system of all inscribed quadrics $\\mathcal{Q}_\\lambda$ of the extended oloid $\\mathcal{O}$ where $\\lambda$ is the system parameter. From this result we conclude parameter equations of the touching curve $\\mathcal{C}_\\lambda$ between $\\mathcal{O}$ and $\\math...

  19. Turbo Codes Extended with Outer BCH Code

    DEFF Research Database (Denmark)

    Andersen, Jakob Dahl

    1996-01-01

    The "error floor" observed in several simulations with the turbo codes is verified by calculation of an upper bound to the bit error rate for the ensemble of all interleavers. Also an easy way to calculate the weight enumerator used in this bound is presented. An extended coding scheme is propose...... including an outer BCH code correcting a few bit errors.......The "error floor" observed in several simulations with the turbo codes is verified by calculation of an upper bound to the bit error rate for the ensemble of all interleavers. Also an easy way to calculate the weight enumerator used in this bound is presented. An extended coding scheme is proposed...

  20. Extending Symfony 2 web application framework

    CERN Document Server

    Armand, Sébastien

    2014-01-01

    Symfony is a high performance PHP framework for developing MVC web applications. Symfony1 allowed for ease of use but its shortcoming was the difficulty of extending it. However, this difficulty has now been eradicated by the more powerful and extensible Symfony2. Information on more advanced techniques for extending Symfony can be difficult to find, so you need one resource that contains the advanced features in a way you can understand. This tutorial offers solutions to all your Symfony extension problems. You will get to grips with all the extension points that Symfony, Twig, and Doctrine o

  1. Market Diffusion of Extended Cycle Hormonal Contraceptives

    Directory of Open Access Journals (Sweden)

    Megen Leeds Schumacher, Pharm.D.

    2012-01-01

    Full Text Available Background: Extended cycle hormonal contraceptives (e.g. Seasonale, Seasonique when introduced in 2003 were considered a very novel approach to contraception. The idea of manipulating the menstrual cycle so that women would experience just four menstruations a year was radical and was assumed to be responsible for the slow acceptance rate among the general public.Objective: This report analyzes two different aspects of the acceptance of this unique idea in the population. The first was the level of usage of extended cycle hormonal contraceptives in the general population, which was measured by a review of sales figures over time in the United States. The second was an examination of market diffusion as it relates to consumer perceptions regarding the characteristics of these products.Methods: To determine the degree of usage of extended cycle hormonal contraceptives the yearly sales, in terms of units sold, were compared with that of other leading methods of hormonal contraception. Along with the data, survey answers were obtained from 65 women who volunteered to participate in the study. Participants were selected randomly to represent the target population to assess the level of awareness about the benefits, risks, and any other concerns regarding the use of extended cycle hormonal contraceptives.Results: The yearly sales data of units sold showed a definitive increase in the sales of extended cycle hormonal contraceptives since their release on the market. The survey results showed an overwhelming awareness in the study population about the extended regimen. However, only about half of the women in the survey group were aware of its benefits. The main concern reported was the perceived significant side effect profile.Conclusion: Though awareness about the extended cycle hormonal contraception regimen was widespread, the survey population was not well informed about the advantages and the disadvantages regarding the degree of severity of side

  2. Dynamic Analysis of Wind Turbine Planetary Gears Using an Extended Harmonic Balance Approach: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Y.; Keller, J.; Parker, R. G.

    2012-06-01

    The dynamics of wind turbine planetary gears with gravity effects are investigated using an extended harmonic balance method that extends established harmonic balance formulations to include simultaneous internal and external excitations. The extended harmonic balance method with arc-length continuation and Floquet theory is applied to a lumped-parameter planetary gear model including gravity, fluctuating mesh stiffness, bearing clearance, and nonlinear tooth contact to obtain the planetary gear dynamic response. The calculated responses compare well with time domain integrated mathematical models and experimental results. Gravity is a fundamental vibration source in wind turbine planetary gears and plays an important role in system dynamics, causing hardening effects induced by tooth wedging and bearing-raceway contacts. Bearing clearance significantly reduces the lowest resonant frequencies of translational modes. Gravity and bearing clearance together lowers the speed at which tooth wedging occurs lower than the resonant frequency.

  3. Structuring very large domain models

    DEFF Research Database (Denmark)

    Störrle, Harald

    2010-01-01

    at a lower level of detail have not been dealt with. This paper aims at filling this gap by reporting personal experiences from a very large scale industrial domain modeling project. There, structuring the logical view turned out to be a critical success factor. We explain the project and its setting......, analyze the role and repercussions of model structuring, and examine the implications model structuring decisions have on other parts of the project. We then explain the model structure abstracted from a very large scale industrial modeling project. Finally, we discuss lessons learned....

  4. Domain Building or Risk Taking

    DEFF Research Database (Denmark)

    Hjort, Katrin; Abrahamsen, Marianne

    2012-01-01

    of the relations between gender, values and family obligation but reveals an interesting difference between two strategies for career development: Domain Building and Risk Taking. Both strategies are applied by both men and women. However, one of them seems to be the most effective with regard to achieve......The Nordic Countries are usually seen as the worlds must successful nations when it comes to gender equality, and the Scandinavian population in general appreciates values traditionally labeled feminine as caretaking and the quality of everyday life. However, the inequalities become obvious...

  5. The domain Green's function method

    Science.gov (United States)

    Moskowitz, Jules W.; Schmidt, K. E.

    1986-09-01

    An implementation of the domain Green's function Monte Carlo algorithm is described. Unlike the short time approximation, the method is variational and exact within the limits of the fixed node approximation. The systems investigated include LiH, Be in the ground and first excited states, a study of the C2v insertion pathway of Be into H2, and H2O. We predict a barrier of 0.190 hartree for the insertion reaction with a statistical accuracy of ±2%. Better than 90% of the correlation energy is recovered in each case, which makes these some of the most accurate computations to date.

  6. The Promise of Domain Adaptation

    Science.gov (United States)

    Mahabal, Ashish A.; Li, Jingling; Vaijanapurkar, Samarth; Bue, Brian; Miller, Adam; Donalek, Ciro; Djorgovski, Stanislav G.; Drake, Andrew J.; Graham, Matthew; CRTS, iPTF

    2016-01-01

    Most new surveys spend an appreciable time in collecting data on which to train classifiers before they can be used on future observations from the same dataset. The result generating phase can start much earlier if the training could incorporate data accumulated from older surveys enhanced with a small set from the new survey. This is exactly what Domain Adaptation (DA) allows us to do. The main idea behind DAs can be summarized thus: if we have two classes of separable objects in some feature space of a Source survey (S), we can define a hyperplane to separate the two types. In a second Target survey (T), for the same features the hyperplane would be inclined differently. DA methods get the mapping between the two hyperplanes using a small fraction of data from the Target (T) survey and can then be used to predict the classes of the remaining majority of data in T. We discuss the parameters that need to be tuned, the difficulties involved, and ways to improve the results. As we move towards bigger, and deeper surveys, being able to use existing labelled information to conduct classification in future surveys will be more cost-effective and promote time efficiency as well. Starting with the light curve data of 50,000 periodic objects from Catalina Real-Time Transient Survey (CRTS), we have applied domain adaptation techniques such as Geodesic Flow Kernel (GFK) with Random forest classifier and Co-training for domain adaptation (CODA) to the CRTS data which has 35,000 points overlapping with Palomar Transient Factory (PTF), and 12,000 with Lincoln Near-Earth Asteroid Research (LINEAR). The results suggest that domain adaptation is an area worth exploring as the knowledge between these surveys is transferable and the approaches to find the mappings between these surveys can be applied to the remaining data as well as for near future surveys such as CRTS-II, Zwicky Transient Facility (ZTF) and the Large Synoptic Survey Telescope (LSST) to name a few at the optical

  7. Enhanced functional and structural domain assignments using ...

    Indian Academy of Sciences (India)

    Unknown

    ) by Seema Namboori, Natasha Mhatre, Sentivel Sujatha,. Narayanaswamy Srinivasan and Shashi Bhushan Pandit. The three-dimensional structure and subcellular localization of various domains and sub-domains of. Rv1318c, a putative ...

  8. Compiling dictionaries using semantic domains | Moe | Lexikos

    African Journals Online (AJOL)

    larities in various lists of semantic domains developed for languages around the world. Using a standardized list of domains to classify multiple dictionaries opens up possibilities for cross-lin-guistic research into semantic and lexical universals.

  9. Critical Coulomb Wedge Theory Applied to Hyper-Extended Rifted Margins: A New Perspective

    Science.gov (United States)

    Nirrengarten, M.; Manatschal, G.; Yuan, X.; Kusznir, N. J.; Maillot, B.

    2016-12-01

    Field studies, borehole data and seismic sections show that hyper-extended domains at magma-poor rifted margins: 1) deform predominantly in the brittle field, 2) form wedge shape terminations of the continental crust, and 3) develop a frictional décollement between the hyper-extended crust and the underlying serpentinized mantle. These three observations are also the three requirements to apply the Critical Coulomb Wedge (CCW) theory, which describes the stability limit of a frictional wedge over a décollement. We measure the surface slope and detachment dip of hyper-extended wedges at magma-poor margins to compare them with the stability envelopes of CCW theory. Our analysis shows that lower plate margins, forming the footwall of the major extensional detachment faults, correspond to gravitational wedges. In contrast upper plate margins, forming the hanging wall of major extensional detachment faults, are tectonic extensional wedges. Dip measurements of the lower plate margins cluster on the CCW stability limits, which implies that lower plate wedges have similar shapes and that they are gravitationally stable. Upper plate margins are more complex and are not always at the critical shape due to the evolution of the underlying detachment dip and re-localization of the deformation on new detachment faults. The architecture of hyper-extended wedges results from the interaction between rocks physical properties (frictional parameters and fluid pressures) and the localization of deformation processes. Interpretation of hyper-extended domains with seismic sections is often complex due to thick post-tectonic sediments or salt layers. The application of CCW theory on hyper-extended rifted margins provides a new framework to interpret the fault pattern and its associated sedimentary architecture. In particular the application of CCW theory can explain the formation of extensional allochthons and continentward dipping faults.

  10. The Private Legal Governance of Domain Names

    DEFF Research Database (Denmark)

    Schovsbo, Jens Hemmingsen

    2016-01-01

    ) and the Danish Complaints Board for Internet Domain Names (the Board) to discuss how and to what extent the domain name system balances interests between trademark owners and other users of domain names and secures the rule of law (legal certainty and predictability) with a special focus on cases where...... trademarks are used as (parts of) domain names to express criticism of the trademark holder or the trademark itself (e.g. “TMsucks.com” / “lorteTM.dk”)....

  11. SENSITIVITY OF EXTENDED-SPECTRUM β - LACTAMASES ...

    African Journals Online (AJOL)

    DR. AMINU

    extract and fractions were tested for antimicrobial activity against confirmed extended spectrum β- lactamases (ESBLs) producing enterobacteriaceae isolates of Escherichia coli, ... oncology and neonatal units (Kohler et al, 1999). Medicinal plants have long been utilized as a source of therapeutic agents worldwide due to ...

  12. Apixaban for Extended Treatment of Venous Thromboembolism

    NARCIS (Netherlands)

    Agnelli, Giancarlo; Buller, Harry R.; Cohen, Alexander; Curto, Madelyn; Gallus, Alexander S.; Johnson, Margot; Porcari, Anthony; Raskob, Gary E.; Weitz, Jeffrey I.; Gallus, Alexander; Raskob, Gary; Weitz, Jeffrey; Prins, Martin; Brandjes, Dees; Kolbach, Dinanda; Limburg, Martinus; Mac Gillavry, Melvin; Otten, Johannes Martinus; Peters, Ron; Roos, Yvo; Segers, Annelise; Slagboom, Ton; Bounameaux, Henry; Hirsh, Jack; Samama, Meyer Michel; Wedel, Hans; Masiukiewicz, Urszula; Pak, Raphael; Sanders, Paul; Sisson, Melanie; Sullivan, Beth; Thompson, John; Auerbach, Jennifer; Cesario, Lynne; Gamero, Miguel; Gordon, Margot; Griffiths, Angela; Noble, Melanie; Ott, Jana; Pennington, Ann; Peffer, Allison; Reinhold, Peggy; Simmons, Melanie; Urwin, Keri; Ceresetto, Jose; McRae, Simon; Pabinger, Ingrid; Pereira, Adamastor Humberto; Spencer, Fred; Gorican, Karel; Husted, Steen Elkiaer; Mottier, Dominique; Harenberg, Job; Pinjala, Ramakrishna; Zeltser, David; Imberti, Davide; Sandset, Morten; Torbicki, Adam; Fijalkowska, Anna; Albino, Jose Pereira; Kirienko, Alexander; Shvarts, Yury; Monreal, Manuel; Jacobson, Barry; Dolan, Gerry; Gudz, Ivan; Ortel, Tom; Spyropoulos, Alex; Torbicki, A.; Fijalkowska, A.; Skupyy, O.; Beryer-Westendorf, J.; de Pellegrin, A.; Prasol, V.; Schellong, S.; Jacobson, B.; Falvo, N.; Abramov, I.; Cizek, V.; Husted, S.; Desai, S.; Gudz, I.; Barillari, G.; Sergeev, O.; Chetter, I.; Inbal, A.; McCollum, C.; Shvalb, P.; Torp-Pedersen, C.; Vasylyuk, S.; Kraemmer Nielsen, H.; Pernod, G.; Schmidt, J.; Bova, C.; Gerasymov, V.; Pabinger-Fasching, I.; Skalicka, L.; Zaichuk, A.; Achkar, A.; Bremmelgaard, A.; Chochola, J.; Gould, T.; Khalafallah, A.; Jakobsen, T.; Rose, P.; Zhukov, B.; Dedek, V.; Mirete Ferrer, J.; Pesant, Y.; Repin, A.; Salem, H.; Solis Morales, L.; Spacek, R.; Cannon, K.; Grzelakowski, P.; Jindal, R.; Pereira, A.; Zidkova, E.; Ambrosio, G.; Cardozo, M.; Dunaj, M.; Gallus, A.; Gavish, D.; Ghanima, W.; Harenberg, J.; Leduc, J. J.; Mismetti, P.; Panico, M.; Porreca, E.; Riera, A.; Bareford, D.; Chong, B.; Dvoryashina, I.; Gómez Cerezo, J.; Kobza, I.; Nielsen, T.; Pendleton, R.; Pullman, J.; Schiffman, G.; Stanbro, M.; Zwettler, U.; Aquilanti, S.; Bratsch, H.; Cohen, K.; Elias, D.; Gan, E.; Holaj, R.; Klinke, W.; Liu, H. S. Y.; Sandset, P. M.; van Nieuwenhuizen, E.; Álvarez-Sala, L. A.; Basson, M.; Braester, A.; Bura-Riviere, A.; Calvo Vargas, C.; Cohen, A.; Correa, J.; Elias, M.; Frost, L.; Imberti, D.; Landolfi, R.; Marschang, P.; Moreira, R.; Mottier, D.; Natarajan, S.; Pottier, P.; Tosetto, A.; Tuxen, C.; Vöhringer, H. F.; Alexander, A.; Barbarash, O.; Fajardo Campos, P.; Graham, M.; Gubka, O.; Hudcovic, M.; Hussein, O.; Jackson, D.; Katelnitskiy, I.; Lawall, H.; Monreal, M.; Palareti, G.; Poggio, R.; Roos, J.; Simonneau, G.; Smith, S. W.; Szopinski, P.; Ortel, T.; Zimlichman, R.; Bridgers, D.; Colan, D.; Czekalski, P.; de Jong, D.; Fortinez, J. T.; Garcia Bragado, F.; Harrington, D.; Izbicki, G.; Kadr, H.; Koslow, A.; Loftus, I.; Marais, H.; Neumeister, A.; Oliven, A.; Palla, A.; Pop, C.; Prandoni, P.; Puskas, A.; Sanchez Llamas, F.; Shotan, A.; Shvarts, Y.; Singh, P.; Tveit, A.; Baker, R.; Borja, V.; Brenner, B.; Brown, H.; Ceresetto, J.; Cha, T. J.; Cohen, Y.; D'Angelo, A.; Dhar, A.; Friis, E.; Hueur, H.; Jiménez Rodríguez Madridejos, R.; Karl, J.; Karrasch, J.; Lishner, M.; Manenti, E.; McRae, S.; Meneveau, N.; Nguyen, D.; Sanchez-Escalante, L.; Santoscoy Ibarra, J.; Sokurenko, G.; Staroverov, I.; Stein, R.; Abdullah, I.; Agnelli, G.; Alcocer Gamba, M.; Balanda, J.; Bruckner, I.; Calabuig Alborch, J.; Caraco, Y.; Comerota, A.; Cromer, M.; de Araujo Filho, J.; de los Rios Ibarra, M.; Diaz-Castañon, J.; Doshi, A.; Ebrahim, I.; Fessel, W. J.; Fletcher, E.; Fourie, N.; Fu, C.; Gutowski, P.; Haddad, G.; Hoffman, U.; Jardula, M.; Kvasnicka, T.; Lewczuk, J.; Leyden, M.; Livneh, A.; Lodigiani, C.; Lovell, C.; Miekus, P.; Paloma, M. J.; Parakh, R.; Raval, M.; Schmidt-Lucke, J.; Shtutin, O.; Soroka, V.; Stevens, D.; Sulik, P.; Tay, J. C.; Vejby-Christensen, H.; Vinereanu, D.; Baghestanian, M.; Bono, J.; Cerana, S.; Freire, A.; Gibson, K.; Giumelli, C.; Iastrebner, C.; Karpenko, A.; Kelly, A.; Lacroix, P.; LaFata, J.; Lobo, S.; Macik, B. G.; Marchena Yglesias, P.; Nishinari, K.; Pinjala, R.; Podczeck-Schweighofer, A.; Raby, K.; Sirpal, S.; Solymoss, S.; Spencer, F.; van Zyl, L.; Vargas Núñez, J. A.; von Bilderling, P.; Warr, T.; Wronski, J.; Wurster, M.; Albino, J. A.; Albuquerque, L.; Averill, F.; Baek, S. H.; Bello, F.; Bergoeing, M.; Blanc, F. X.; Bloomberg, R.; Bolster, D.; Brockmyre, A.; Calimano, C.; Checketts, D.; Cieplinski, W.; Chervu, A.; Collado, F.; Denaro, C.; Gaciong, Z.; Game, M.; Iskander, A.; Kaatz, S.; Kim, D. I.; Koura, F.; Laguna, F.; Lanas Zanetti, F.; Lindhoff-Last, E.; Melaniuk, M.; Meade, A.; Murphy, T.; Ng, H. J.; Páramo Fernández, J. A.; Patil, C.; Piovella, F.; Prisco, D.; Pruszczyk, P.; Reimers, G.; Rivera, E.; Rodriguez-Cintron, W.; Rosenthal, S.; Salbach, P.; Salvador, D.; Schuller, D.; Siragusa, S.; Staniszewski, R.; Torp, R.; Vora, K.; Yip, G.; Alfieri, A.; Belaji, V.; Bhagavan, N.; Carnovali, M.; Cobos Segarra, J.; Di Todaro, F.; Dowell, A.; Corder, C.; Crispin, P.; Cuadrado, J.; Flippo, G.; Fraiz, J.; Guillaumon, A.; Gvora, T.; Hakki, S.; Harris, L.; Ison, R.; Htun, P. T.; Jasani, R.; Kates, M.; Kaminski, L.; Kamerkar, D.; Kirienko, A.; Kroger, K.; LaPerna, L.; Leiva, J.; Luber, J.; McCann, A.; McKenzie, W.; Menna Barreto, S.; Moran, J.; Nikulnikov, P.; Paliwal, Y.; Patel, M.; Pilger, E.; Renwick, W.; Shevela, A.; Starosiliz, D.; Stringam, S.; Spyropoulos, A.; To, R.; Updegrove, J.; van Bellen, B.; Waintrub, M.; White, J.; Yeo, E.; Zangroniz, P.; Zeltser, D.

    2013-01-01

    BACKGROUND Apixaban, an oral factor Xa inhibitor that can be administered in a simple, fixed-dose regimen, may be an option for the extended treatment of venous thromboembolism. METHODS In this randomized, double-blind study, we compared two doses of apixaban (2.5 mg and 5 mg, twice daily) with

  13. Extending and embedding the Python interpreter

    NARCIS (Netherlands)

    G. van Rossum (Guido)

    1995-01-01

    textabstractPython is an interpreted, object-oriented programming language. This document describes how to write modules in C or C++ to extend the Python interpreter with new modules. Those modules can define new functions but also new object types and their methods. The document also describes

  14. Observational constraints on extended Chaplygin gas cosmologies

    Indian Academy of Sciences (India)

    We investigate cosmological models with extended Chaplygin gas (ECG) as a candidate for dark energy and determine the equation of state parameters using observed data namely, observed Hubble data, baryon acousticoscillation data and cosmic microwave background shift data. Cosmological models are investigated ...

  15. The Extended Mind Thesis and Mechanistic Explanations

    DEFF Research Database (Denmark)

    Fazekas, Peter

    2013-01-01

    The Extended Mind Thesis (EMT) is traditionally formulated against the bedrock of functionalism, and ongoing debates are typically bogged down with questions concerning the exact relationship between EMT and different versions of functionalism. In this paper, I offer a novel ally for EMT: the new...

  16. Extended working hours: Impacts on workers

    Science.gov (United States)

    D. Mitchell; T. Gallagher

    2010-01-01

    Some logging business owners are trying to manage their equipment assets by increasing the scheduled machine hours. The intent is to maximize the total tons produced by a set of equipment. This practice is referred to as multi-shifting, double-shifting, or extended working hours. One area often overlooked is the impact that working non-traditional hours can have on...

  17. Extended Resin Composite Restorations: Techniques and Procedures

    NARCIS (Netherlands)

    Loomans, B.A.C.; Hilton, T.

    2016-01-01

    This article gives an overview of the state of the art of different restorative treatment procedures and techniques needed for placing extended posterior resin composite restorations. Clinical aspects related to the procedure are discussed and reviewed based on the current literature, such as the

  18. [Combined hormonal contraception in cycles artificially extended].

    Science.gov (United States)

    Bustillos-Alamilla, Edgardo; Zepeda-Zaragoza, J; Hernández-Ruiz, M A; Briones-Landa, Carlos Humberto

    2010-01-01

    To compare the bleeding patterns, satisfaction and tolerability of 3 different contraceptive in an extended regimens in the service of Family Planning of the North Central Hospital of PEMEX. Healthy, adult women with desire of contraception for one year (N 120) were randomly assigned to receive oral contraceptive drospirenone/ethinyl E2 (group1), the norelgestromin/ethinyl E2 transdermal patch (group 2) and vaginal ring etonogestrel/ ethinyl E2 (group 3) in an extended regimen (42 consecutive days, 1 hormone-free week). Study assessments were conducted at scheduled visits at the time of initial screening, at baseline after 1, 3, 6, and 12 months. Subjects recorded menstrual associated symptoms bleeding data and completed satisfaction questionnaires. Subjects and investigators provided overall assessments of the regimens. Extended use of 3 different contraceptive resulted in fewer bleeding days in every group (66.6%, 55% and 58.3% P 0.0024), and less mastalgia and menstrual pain. Subjects were highly satisfied with three regimens (93.3%, 96.6% and 91.6% P 0.00421). Although not mayor adverse events were reported with this regimen, there was an increase in spotting days; it decreased with each successive cycle of therapy. Efficacy and safety were similar to those reported for traditional cycle. Extended-contraceptive regimen delays menses and reduces bleeding, a profile that may be preferred by women who seek flexibility with their contraceptive method.

  19. Extending the Instructional Systems Development Methodology.

    Science.gov (United States)

    O'Neill, Colin E.

    1993-01-01

    Describes ways that components of Information Engineering (IE) methodology can be used by training system developers to extend Instructional Systems Development (ISD) methodology. Aspects of IE that are useful in ISD are described, including requirements determination, group facilitation, integrated automated tool support, and prototyping.…

  20. Antibiotic Susceptibility Pattern of Extended Spectrum ...

    African Journals Online (AJOL)

    Purpose: To evaluate the antibiotic susceptibility pattern of various bacterial pathogens including extended spectrum betalactamase (ESBL) producers in Kano, Nigeria. Method: A total of 604 consecutive clinical samples obtained from Aminu Kano Teaching Hospital. (AKTH), Kano between January and July 2010 were ...

  1. Q-Method Extended Kalman Filter

    Science.gov (United States)

    Zanetti, Renato; Ainscough, Thomas; Christian, John; Spanos, Pol D.

    2012-01-01

    A new algorithm is proposed that smoothly integrates non-linear estimation of the attitude quaternion using Davenport s q-method and estimation of non-attitude states through an extended Kalman filter. The new method is compared to a similar existing algorithm showing its similarities and differences. The validity of the proposed approach is confirmed through numerical simulations.

  2. Some Remarks on the Extended Galilean Transformation.

    Science.gov (United States)

    Greenberger, Daniel M.

    1979-01-01

    The extended Galilean transformation carries an inertial frame into a rigid frame with uniform spatial, but arbitrary translational acceleration. Besides being useful in discussing the equivalence principle, this transformation provides a physical interpretation for the theorem in nonrelativistic quantum mechanics, that we cannot coherently…

  3. Extended plate and beam demonstration home

    Science.gov (United States)

    Patricia Gunderson; Vladimir Kochkin; Xiping Wang

    2018-01-01

    An extended plate and beam (EP&B) design was developed at Home Innovation Research Labs (Upper Marlboro, Maryland) in an effort to provide traditional light-frame wall construction details that are compatible with continuous insulating sheathing. This would encourage wide-spread adoption of high-R walls and promote greater energy efficiency in new houses. The...

  4. Modeling survival data extending the cox model

    CERN Document Server

    Therneau, Terry M

    2000-01-01

    Extending the Cox Model is aimed at researchers, practitioners, and graduate students who have some exposure to traditional methods of survival analysis The emphasis is on semiparametric methods based on the proportional hazards model The inclusion of examples with SAS and S-PLUS code will make the book accessible to most working statisticians

  5. Impact of Divorce on the Extended Family.

    Science.gov (United States)

    Fisher, Esther Oshiver, Ed.

    1981-01-01

    Contains 11 articles focusing on psychological, sociological, legal, economic, and clinical aspects of divorce and the extended family. Examines issues including: (1) dynamics of the family kinship system; (2) family life cycle and divorce; (3) kin role in divorce adjustment; and (4) changes in family relationships. (RC)

  6. The inflation sector of extended inflation

    Science.gov (United States)

    Kolb, Edward W.

    1991-01-01

    In extended inflation, the inflationary era is brought to a close by the process of percolation of true vacuum bubbles produced in a first-order phase transition. This paper discusses several effects that might obtain if the universe undergoes an inflationary first-order phase transition.

  7. Extended Learning Time: Research and Resources

    Science.gov (United States)

    Stelow, Shawn; Holland, Jenifer Gager; Jackson, Rebecca

    2012-01-01

    In recent years policymakers have increasingly looked to Extended Learning Time (ELT) as a means of improving student outcomes. As a result, some school districts have increased academic time for students by adding time to the school day or days to the school year. In other communities, schools and community-based organizations have partnered to…

  8. Modelling extended lactations of dairy cows

    NARCIS (Netherlands)

    Vargas, B.; Koops, W.J.; Herrero, M.; Arendonk, van J.A.M.

    2000-01-01

    Nine mathematical models were compared for their ability to predict daily milk yields (n = 294,986) in standard 305-d and extended lactations of dairy cows of Costa Rica. Lactations were classified by parity (first and later), lactation length (9 to 10, 11 to 12, 13 to 14, 15 to 16, and 16 to 17

  9. Incidence and antimicrobial susceptibility pattern of extended ...

    African Journals Online (AJOL)

    During the past few years, extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and other species of Enterobacteriaceae have become a matter of great concern in human and veterinary medicine. Several studies in recent years documented the prevalence and occurrence of ESBLproducing ...

  10. Prevalence of Extended Spectrum Beta Lactamases (ESBL ...

    African Journals Online (AJOL)

    Resistance to broad spectrum β lactams, mediated by extended spectrum beta lactamase (ESβL) is an increasing problem worldwide. Production of these enzymes in clinical infections can result in treatment failure if one of the second or third generation cephalosporins is used. This study investigates the incidence of ESBL ...

  11. Schedule-extended synchronous dataflow graphs

    NARCIS (Netherlands)

    Damavandpeyma, M.; Stuijk, S.; Basten, T.; Geilen, M.; Corporaal, H.

    2013-01-01

    Synchronous dataflow graphs (SDFGs) are used extensively to model streaming applications. An SDFG can be extended with scheduling decisions, allowing SDFG analysis to obtain properties, such as throughput or buffer sizes for the scheduled graphs. Analysis times depend strongly on the size of the

  12. Short Communication: Production of extended spectrum beta ...

    African Journals Online (AJOL)

    Multidrug resistant strains of Klebsiella pneumoniae and Escherichia coli constitute a problem in many hospitals. The antibiotic susceptibility profile and the Production of Extended Spetrum Beta-Lactamase (ESBL) of the strains of Klebsiella pneumoniae and Escherichia coli were assessed by the Kirby-Bauer technique and ...

  13. Remarks on the extended characteristic uncertainty relations

    Energy Technology Data Exchange (ETDEWEB)

    Trifonov, D.A. [Institute for Nuclear Research, Sofia (Bulgaria)

    2001-03-09

    Three remarks concerning the form and the range of validity of the state-extended characteristic uncertainty relations (URs) are presented. A more general definition of the uncertainty matrix for pure and mixed states is suggested. Some new URs are provided. (author). Letter-to-the-editor.

  14. Extending the frontiers of employment regulation:

    African Journals Online (AJOL)

    UWC

    legislation will be needed in changing the complex of political, social and economic factors by which that inequality ..... workers is prevalent.57 While SD7 does not deal with discrimination, the EEA extends comprehensive ..... Employer indifference or resistance (active or passive) remains the single greatest barrier to more ...

  15. Diagrammar in an extended theory of gravity

    Science.gov (United States)

    Dunbar, David C.; Godwin, John H.; Jehu, Guy R.; Perkins, Warren B.

    2017-08-01

    We show how the S-matrix of an extended theory of gravity defined by its three-point amplitudes can be constructed by demanding factorisation. The resultant S-matrix has tree amplitudes obeying the same soft singularity theorems as Einstein gravity including the sub-sub-leading terms.

  16. Experimental limits on antigravity in extended supergravity

    OpenAIRE

    Bellucci, S.; Faraoni, V.

    1995-01-01

    The available tests of the equivalence principle constrain the mass of the Higgs-like boson appearing in extended supergravity theories. We determine the constraints imposed by the present and future high precision experiments on the antigravity fields arising from $N=2,8$ supergravity.

  17. SENSITIVITY OF EXTENDED-SPECTRUM β - LACTAMASES ...

    African Journals Online (AJOL)

    DR. AMINU

    INTRODUCTION. Extended spectrum β-lactamases (ESBLs) are plasmid mediated enzymes that confer resistance to bacterial pathogens. The enzymes pose threat to current β- .... Brick-red precipitates at the bottom of the test tubes would denote the presence of reducing sugars in accordance with Brain and. Turner (1975).

  18. Venus: No Breaks from an Extended Childhood

    Science.gov (United States)

    Moore, W. B.; Kankanamge, D. G. J.

    2017-05-01

    High surface temperatures lead to lower heat flow and lower stress as planets transition out of the heat-pipe mode into subsolidus convection. This causes Venus to miss the window for plate tectonics due to an extended heat-pipe childhood.

  19. Horizant: gabapentin enacarbil extended-release tablets

    National Research Council Canada - National Science Library

    2011-01-01

    ... enacarbil extended-release tablets for the treatment of moderate-to-severe RLS in adults. Gabapentin enacarbil is not recommended for patients required to sleep during the daytime and remain awake at night. Efficacy. Gabapentin enacarbil efficacy was established in two 12-week clinical studies in adults diagnosed with RLS using the International Restless ...

  20. The extended arm of health professionals?

    DEFF Research Database (Denmark)

    Norlyk, Annelise; Martinsen, Bente

    2013-01-01

    responsibility for both the patient's well-being and for the patient's compliance with the daily regimen. Relatives were caught in a conflicting double role. They were the extended arm of the health professionals but also the caring, supporting partner. A tension arose between relatives' desire to help...

  1. NMR structure of the flavin domain from soluble methane monooxygenase reductase from Methylococcus capsulatus (Bath).

    Science.gov (United States)

    Chatwood, Lisa L; Müller, Jens; Gross, John D; Wagner, Gerhard; Lippard, Stephen J

    2004-09-28

    Soluble methane monooxygenase (sMMO) catalyzes the hydroxylation of methane by dioxygen to methanol, the first step in carbon assimilation by methanotrophs. This multicomponent system transfers electrons from NADH through a reductase component to the non-heme diiron center in the hydroxylase where O(2) is activated. The reductase component comprises three distinct domains, a [2Fe-2S] ferredoxin domain along with FAD- and NADH-binding domains. We report the solution structure of the reduced 27.6 kDa FAD- and NADH-binding domains (MMOR-FAD) of the reductase from Methylococcus capsulatus (Bath). The FAD-binding domain consists of a six-stranded antiparallel beta-barrel and one alpha-helix, with the first 10 N-terminal residues unstructured. In the interface between the two domains, the FAD cofactor is tightly bound in an unprecedented extended conformation. The NADH-binding domain consists of a five-stranded parallel beta-sheet with four alpha-helices packing closely around this sheet. MMOR-FAD is structurally homologous to other FAD-containing oxidoreductases, and we expect similar structures for the FAD/NADH-binding domains of reductases that occur in other multicomponent monooxygenases.

  2. Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.

    Science.gov (United States)

    Kim, Young Mee; Choi, Byong-Seok

    2010-11-01

    The helicase and RNaseD C-terminal (HRDC) domain, conserved among members of the RecQ helicase family, regulates helicase activity by virtue of variations in its surface residues. The HRDC domain of Bloom syndrome protein (BLM) is known as a critical determinant of the dissolution function of double Holliday junctions by the BLM-Topoisomerase IIIα complex. In this study, we determined the solution structure of the human BLM HRDC domain and characterized its DNA-binding activity. The BLM HRDC domain consists of five α-helices with a hydrophobic 3(10)-helical loop between helices 1 and 2 and an extended acidic surface comprising residues in helices 3-5. The BLM HRDC domain preferentially binds to ssDNA, though with a markedly low binding affinity (K(d) ∼100 μM). NMR chemical shift perturbation studies suggested that the critical DNA-binding residues of the BLM HRDC domain are located in the hydrophobic loop and the N-terminus of helix 2. Interestingly, the isolated BLM HRDC domain had quite different DNA-binding modes between ssDNA and Holliday junctions in electrophoretic mobility shift assay experiments. Based on its surface charge separation and DNA-binding properties, we suggest that the HRDC domain of BLM may be adapted for a unique function among RecQ helicases--that of bridging protein and DNA interactions.

  3. Secondary structure and domain architecture of the 23S and 5S rRNAs

    Science.gov (United States)

    Petrov, Anton S.; Bernier, Chad R.; Hershkovits, Eli; Xue, Yuzhen; Waterbury, Chris C.; Hsiao, Chiaolong; Stepanov, Victor G.; Gaucher, Eric A.; Grover, Martha A.; Harvey, Stephen C.; Hud, Nicholas V.; Wartell, Roger M.; Fox, George E.; Williams, Loren Dean

    2013-01-01

    We present a de novo re-determination of the secondary (2°) structure and domain architecture of the 23S and 5S rRNAs, using 3D structures, determined by X-ray diffraction, as input. In the traditional 2° structure, the center of the 23S rRNA is an extended single strand, which in 3D is seen to be compact and double helical. Accurately assigning nucleotides to helices compels a revision of the 23S rRNA 2° structure. Unlike the traditional 2° structure, the revised 2° structure of the 23S rRNA shows architectural similarity with the 16S rRNA. The revised 2° structure also reveals a clear relationship with the 3D structure and is generalizable to rRNAs of other species from all three domains of life. The 2° structure revision required us to reconsider the domain architecture. We partitioned the 23S rRNA into domains through analysis of molecular interactions, calculations of 2D folding propensities and compactness. The best domain model for the 23S rRNA contains seven domains, not six as previously ascribed. Domain 0 forms the core of the 23S rRNA, to which the other six domains are rooted. Editable 2° structures mapped with various data are provided (http://apollo.chemistry.gatech.edu/RibosomeGallery). PMID:23771137

  4. Secondary structure and domain architecture of the 23S and 5S rRNAs.

    Science.gov (United States)

    Petrov, Anton S; Bernier, Chad R; Hershkovits, Eli; Xue, Yuzhen; Waterbury, Chris C; Hsiao, Chiaolong; Stepanov, Victor G; Gaucher, Eric A; Grover, Martha A; Harvey, Stephen C; Hud, Nicholas V; Wartell, Roger M; Fox, George E; Williams, Loren Dean

    2013-08-01

    We present a de novo re-determination of the secondary (2°) structure and domain architecture of the 23S and 5S rRNAs, using 3D structures, determined by X-ray diffraction, as input. In the traditional 2° structure, the center of the 23S rRNA is an extended single strand, which in 3D is seen to be compact and double helical. Accurately assigning nucleotides to helices compels a revision of the 23S rRNA 2° structure. Unlike the traditional 2° structure, the revised 2° structure of the 23S rRNA shows architectural similarity with the 16S rRNA. The revised 2° structure also reveals a clear relationship with the 3D structure and is generalizable to rRNAs of other species from all three domains of life. The 2° structure revision required us to reconsider the domain architecture. We partitioned the 23S rRNA into domains through analysis of molecular interactions, calculations of 2D folding propensities and compactness. The best domain model for the 23S rRNA contains seven domains, not six as previously ascribed. Domain 0 forms the core of the 23S rRNA, to which the other six domains are rooted. Editable 2° structures mapped with various data are provided (http://apollo.chemistry.gatech.edu/RibosomeGallery).

  5. Crystal Structure of the Passenger Domain of the Escherichia coli Autotransporter EspP

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Shekeb; Mian, Hira S.; Sandercock, Linda E.; Chirgadze, Nickolay Y.; Pai, Emil F. (Toronto); (OCI)

    2013-03-07

    Autotransporters represent a large superfamily of known and putative virulence factors produced by Gram-negative bacteria. They consist of an N-terminal 'passenger domain' responsible for the specific effector functions of the molecule and a C-terminal '{beta}-domain' responsible for translocation of the passenger across the bacterial outer membrane. Here, we present the 2.5-{angstrom} crystal structure of the passenger domain of the extracellular serine protease EspP, produced by the pathogen Escherichia coli O157:H7 and a member of the serine protease autotransporters of Enterobacteriaceae (SPATEs). Like the previously structurally characterized SPATE passenger domains, the EspP passenger domain contains an extended right-handed parallel {beta}-helix preceded by an N-terminal globular domain housing the catalytic function of the protease. Of note, however, is the absence of a second globular domain protruding from this {beta}-helix. We describe the structure of the EspP passenger domain in the context of previous results and provide an alternative hypothesis for the function of the {beta}-helix within SPATEs.

  6. Structures of the NLRP14 pyrin domain reveal a conformational switch mechanism regulating its molecular interactions

    Energy Technology Data Exchange (ETDEWEB)

    Eibl, Clarissa; Hessenberger, Manuel; Wenger, Julia; Brandstetter, Hans, E-mail: hans.brandstetter@sbg.ac.at [University of Salzburg, Billrothstrasse 11, 5020 Salzburg (Austria)

    2014-07-01

    Pyrin domains (PYDs) recruit downstream effector molecules in NLR signalling. A specific charge-relay system suggests a the formation of a signalling complex involving a PYD dimer. The cytosolic tripartite NLR receptors serve as important signalling platforms in innate immunity. While the C-terminal domains act as sensor and activation modules, the N-terminal death-like domain, e.g. the CARD or pyrin domain, is thought to recruit downstream effector molecules by homotypic interactions. Such homotypic complexes have been determined for all members of the death-domain superfamily except for pyrin domains. Here, crystal structures of human NLRP14 pyrin-domain variants are reported. The wild-type protein as well as the clinical D86V mutant reveal an unexpected rearrangement of the C-terminal helix α6, resulting in an extended α5/6 stem-helix. This reordering mediates a novel symmetric pyrin-domain dimerization mode. The conformational switching is controlled by a charge-relay system with a drastic impact on protein stability. How the identified charge relay allows classification of NLRP receptors with respect to distinct recruitment mechanisms is discussed.

  7. Teaching-Learning in the Affective Domain

    Science.gov (United States)

    Holt, Brett J.; Hannon, James C.

    2006-01-01

    Affect is an important domain in which children learn. The affective domain of learning in physical education focuses on feelings, values, social behavior, and attitudes as they relate to human movement. Learning in the affective domain in physical education means that students learn such concepts as sportsmanship, "fair play," respect for others,…

  8. On the structure of order domains

    DEFF Research Database (Denmark)

    Geil, Olav; Pellikaan, Ruud

    2002-01-01

    The notion of an order domain is generalized. The behaviour of an order domain by taking a subalgebra, the extension of scalars, and the tensor product is studied. The relation of an order domain with valuation theory, Gröbner algebras, and graded structures is given. The theory of Gröbner bases...

  9. A Domain Standard for Land Administration

    NARCIS (Netherlands)

    Lemmen, C.; Van Oosterom, P.; Van der Molen, P.

    2013-01-01

    This paper presents the design of a Domain Model for Land Administration (LA). As a result a formal International Standard is available: ISO 19152 Geographic Information – Land Administration Domain Model (LADM) (ISO, 2012). Domain specific standardisation is needed to capture the semantics of the

  10. implementation of spatial domain homomorphic filtering

    African Journals Online (AJOL)

    eobe

    There is a lot of background literature on frequency- domain Homomorphic ... developed in the literature [4-6, 8-9]. This paper ..... Processing times for spatial and frequency domain filter. Colour Image Dimensions Spatial domain processing time(s) Frequency domainprocessing time(s). Girl. 256 × 256. 0.058. 0.914. Swan.

  11. Implementation of Spatial Domain Homomorphic Filtering on ...

    African Journals Online (AJOL)

    This paper describes the analysis of the Homomorphic filtering algorithm, the equivalency between the frequency and spatial-domain methods and the implementation of low-pass and high-pass spatial domain Homomorphic filter in low power embedded devices. It is shown that the Homomorphic filter in the spatial domain ...

  12. $\\omega$-Euclidean domain and Laurent series

    Directory of Open Access Journals (Sweden)

    O. M. Romaniv

    2016-06-01

    Full Text Available It is proved that a commutative domain $R$ is $\\omega$-Euclidean if and only if the ring of formal Laurent series over $R$ is $\\omega$-Euclidean domain. It is also proved that every singular matrice over ring of formal Laurent series $R_{X}$ are products of idempotent matrices if $R$ is $\\omega$ -Euclidean domain.

  13. Static domain wall in braneworld gravity

    Energy Technology Data Exchange (ETDEWEB)

    Abdalla, M.C.B.; Carlesso, P.F. [UNESP, Universidade Estadual Paulista, Instituto de Fisica Teiorica, Rua Dr. Bento Teobaldo Ferraz 271, Bloco II, Barra-Funda, Caixa Postal 70532-2, Sao Paulo, SP (Brazil); Hoff da Silva, J.M. [UNESP, Universidade Estadual Paulista, Departamento de Fisica e Quimica, Guaratingueta, SP (Brazil)

    2014-01-15

    In this paper we consider a static domain wall inside a 3-brane. Different from the standard achievement obtained in General Relativity, the analysis performed here gives a consistency condition for the existence of static domain walls in a braneworld gravitational scenario. Also the behavior of the domain wall's gravitational field in the newtonian limit is shown. (orig.)

  14. Latent domain models for statistical machine translation

    NARCIS (Netherlands)

    Hoàng, C.

    2017-01-01

    A data-driven approach to model translation suffers from the data mismatch problem and demands domain adaptation techniques. Given parallel training data originating from a specific domain, training an MT system on the data would result in a rather suboptimal translation for other domains. But does

  15. Domain Adaption Based on ELM Autoencoder

    National Research Council Canada - National Science Library

    Wan-Yu Deng; Yu-Tao Qu; Qian Zhang

    2017-01-01

      We propose a new ELM Autoencoder (ELM-AE) based domain adaption algorithm which describes the subspaces of source and target domain by ELM-AE and then carries out subspace alignment to project different domains into a common new space...

  16. One Health Core Competency Domains

    Directory of Open Access Journals (Sweden)

    Rebekah Frankson

    2016-09-01

    Full Text Available The emergence of complex global challenges at the convergence of human, animal, and environmental health has catalyzed a movement supporting ‘One Health’ approaches. Despite recognition of the importance of One Health approaches to address these complex challenges, little effort has been directed at identifying the seminal knowledge, skills and attitudes necessary for individuals to successfully contribute to One Health efforts. Between 2008 and 2011, three groups independently embarked on separate initiatives to identify core competencies for professionals involved with One Health approaches. Core competencies were considered critically important for guiding curriculum development and continuing professional education as they describe the knowledge, skills and attitudes required to be effective. A workshop was convened in 2012 to synthesize the various strands of work on One Health competencies. Despite having different mandates, participants, and approaches, all of these initiatives identified similar core competency domains: management; communication and informatics; values and ethics; leadership; teams and collaboration; roles and responsibilities; and systems thinking. These core competency domains have been used to develop new continuing professional education programs for One Health professionals and help university curricula prepare new graduates to be able to contribute more effectively to One Health approaches.

  17. On watermarking in frequency domain

    Science.gov (United States)

    Dasre, Narendrakumar Ramchandra; Patil, Hemraj Ramdas

    2010-02-01

    A wavelet-based image watermarking scheme is proposed, based on insertion of 'logo' image as watermark in midfrequency domain. This new approach provides flexibility in determining the pixel to be watermarked and increases the data hiding capacity. It is easy to implement watermark embedding algorithm as well as the corresponding detection algorithm. The watermarking algorithm is tested under different attacks such as median filtering, image cropping and image compression. It is also robust. The experimental results prove that the method is more tamper proof and less perceptible for any type of images other than well known private methods in frequency domain. In the proposed approach, an original image is decomposed into wavelet coefficients then watermark is embedded through algorithm. The wavelet transform filters can be used as security key for the extraction of inserted watermark. The proposed watermark extraction technique is independent of the original image. The watermark embedded image is produced by taking the inverse 2-D discrete wavelet transform of the altered wavelet decomposition. Here we have given the relation between the area of the channel in which we insert the watermark and the area affected in original image.

  18. Analysis of the Linker Region Joining the Adenylation and Carrier Protein Domains of the Modular Non-Ribosomal Peptide Synthetases

    Science.gov (United States)

    Miller, Bradley R.; Sundlov, Jesse A.; Drake, Eric J.; Makin, Thomas A.; Gulick, Andrew M.

    2014-01-01

    Non-Ribosomal Peptide Synthetases (NRPSs) are multi-modular proteins capable of producing important peptide natural products. Using an assembly-line process the amino acid substrate and peptide intermediates are passed between the active sites of different catalytic domains of the NRPS while bound covalently to a peptidyl carrier protein (PCP) domain. Examination of the linker sequences that join the NRPS adenylation and PCP domains identified several conserved proline residues that are not found in standalone adenylation domains. We examined the roles of these proline residues and neighboring conserved sequences through mutagenesis and biochemical analysis of the reaction catalyzed by the adenylation domain and the fully reconstituted NRPS pathway. In particular, we identified a conserved LPxP motif at the start of the adenylation-PCP linker. The LPxP motif interacts with a region on the adenylation domain to stabilize a critical catalytic lysine residue belonging to the A10 motif that immediately precedes the linker. Further, this interaction with the C-terminal sub-domain of the adenylation domain may coordinate movement of the PCP with the conformational change of the adenylation domain. Through this work, we extend the conserved A10 motif of the adenylation domain and identify residues that enable proper adenylation domain function. PMID:24975514

  19. Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes.

    Science.gov (United States)

    Stone, Matthew B; Shelby, Sarah A; Núñez, Marcos F; Wisser, Kathleen; Veatch, Sarah L

    2017-02-01

    Diverse cellular signaling events, including B cell receptor (BCR) activation, are hypothesized to be facilitated by domains enriched in specific plasma membrane lipids and proteins that resemble liquid-ordered phase-separated domains in model membranes. This concept remains controversial and lacks direct experimental support in intact cells. Here, we visualize ordered and disordered domains in mouse B lymphoma cell membranes using super-resolution fluorescence localization microscopy, demonstrate that clustered BCR resides within ordered phase-like domains capable of sorting key regulators of BCR activation, and present a minimal, predictive model where clustering receptors leads to their collective activation by stabilizing an extended ordered domain. These results provide evidence for the role of membrane domains in BCR signaling and a plausible mechanism of BCR activation via receptor clustering that could be generalized to other signaling pathways. Overall, these studies demonstrate that lipid mediated forces can bias biochemical networks in ways that broadly impact signal transduction.

  20. Word Domain Disambiguation via Word Sense Disambiguation

    Energy Technology Data Exchange (ETDEWEB)

    Sanfilippo, Antonio P.; Tratz, Stephen C.; Gregory, Michelle L.

    2006-06-04

    Word subject domains have been widely used to improve the perform-ance of word sense disambiguation al-gorithms. However, comparatively little effort has been devoted so far to the disambiguation of word subject do-mains. The few existing approaches have focused on the development of al-gorithms specific to word domain dis-ambiguation. In this paper we explore an alternative approach where word domain disambiguation is achieved via word sense disambiguation. Our study shows that this approach yields very strong results, suggesting that word domain disambiguation can be ad-dressed in terms of word sense disam-biguation with no need for special purpose algorithms.

  1. Ferroelectric domain continuity over grain boundaries

    DEFF Research Database (Denmark)

    Mantri, Sukriti; Oddershede, Jette; Damjanovic, Dragan

    2017-01-01

    Formation and mobility of domain walls in ferroelectric materials is responsible for many of their electrical and mechanical properties. Domain wall continuity across grain boundaries has been observed since the 1950's and is speculated to affect the grain boundary-domain interactions, thereby...... orientation. We have also incorporated the effect of grain boundary ferroelectric polarization charge created when any two domains meet at the grain boundary plane. The probability of domain wall continuity for three specific grain misorientations is studied. Use of this knowledge to optimize processing...

  2. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.

    Science.gov (United States)

    Shaw, Stephanie D; Chakrabarti, Sutapa; Ghosh, Gourisankar; Krainer, Adrian R

    2007-09-05

    Serine/arginine-rich (SR) proteins are essential splicing factors with one or two RNA-recognition motifs (RRMs) and a C-terminal arginine- and serine-rich (RS) domain. SR proteins bind to exonic splicing enhancers via their RRM(s), and from this position are thought to promote splicing by antagonizing splicing silencers, recruiting other components of the splicing machinery through RS-RS domain interactions, and/or promoting RNA base-pairing through their RS domains. An RS domain tethered at an exonic splicing enhancer can function as a splicing activator, and RS domains play prominent roles in current models of SR protein functions. However, we previously reported that the RS domain of the SR protein SF2/ASF is dispensable for in vitro splicing of some pre-mRNAs. We have now extended these findings via the identification of a short inhibitory domain at the SF2/ASF N-terminus; deletion of this segment permits splicing in the absence of this SR protein's RS domain of an IgM pre-mRNA substrate previously classified as RS-domain-dependent. Deletion of the N-terminal inhibitory domain increases the splicing activity of SF2/ASF lacking its RS domain, and enhances its ability to bind pre-mRNA. Splicing of the IgM pre-mRNA in S100 complementation with SF2/ASF lacking its RS domain still requires an exonic splicing enhancer, suggesting that an SR protein RS domain is not always required for ESE-dependent splicing activation. Our data provide additional evidence that the SF2/ASF RS domain is not strictly required for constitutive splicing in vitro, contrary to prevailing models for how the domains of SR proteins function to promote splicing.

  3. Blocking-resistant communication through domain fronting

    Directory of Open Access Journals (Sweden)

    Fifield David

    2015-06-01

    Full Text Available We describe “domain fronting,” a versatile censorship circumvention technique that hides the remote endpoint of a communication. Domain fronting works at the application layer, using HTTPS, to communicate with a forbidden host while appearing to communicate with some other host, permitted by the censor. The key idea is the use of different domain names at different layers of communication. One domain appears on the “outside” of an HTTPS request—in the DNS request and TLS Server Name Indication—while another domain appears on the “inside”—in the HTTP Host header, invisible to the censor under HTTPS encryption. A censor, unable to distinguish fronted and nonfronted traffic to a domain, must choose between allowing circumvention traffic and blocking the domain entirely, which results in expensive collateral damage. Domain fronting is easy to deploy and use and does not require special cooperation by network intermediaries. We identify a number of hard-to-block web services, such as content delivery networks, that support domain-fronted connections and are useful for censorship circumvention. Domain fronting, in various forms, is now a circumvention workhorse. We describe several months of deployment experience in the Tor, Lantern, and Psiphon circumvention systems, whose domain-fronting transports now connect thousands of users daily and transfer many terabytes per month.

  4. Study of human phonation in a full-body domain

    Science.gov (United States)

    Saurabh, Shakti; Bodony, Daniel

    2015-11-01

    The generation and propagation of the human voice is studied in two-dimensions using a full-body domain, using direct numerical simulation. The fluid/air in the vocal tract is modeled as a compressible and viscous fluid interacting with the non-linear, viscoelastic vocal folds (VF). The VF tissue material properties are multi-layered, with varying stiffness, and a finite-strain model is utilized and implemented in a quadratic finite element code. The fluid-solid domains are coupled through a boundary-fitted interface and utilize a Poisson equation-based mesh deformation method. The full-body domain includes the near VF region, the vocal tract, a simplified model of the soft palate and mouth, and extends out into the acoustic far-field. A new kind of inflow boundary condition based upon a quasi-one-dimensional formulation with constant sub-glottal volume velocity, which is linked to the VF movement, has been adopted. The sound pressure levels (SPL) measured are realistic and we analyze their connection to the VF dynamics and glottal and vocal tract geometries. Supported by the National Science Foundation (CAREER award number 1150439).

  5. Adaptive Semiactive Cable Vibration Control: A Frequency Domain Perspective

    Directory of Open Access Journals (Sweden)

    Z. H. Chen

    2017-01-01

    Full Text Available An adaptive solution to semiactive control of cable vibration is formulated by extending the linear quadratic Gaussian (LQG control from time domain to frequency domain. Frequency shaping is introduced via the frequency dependent weights in the cost function to address the control effectiveness and robustness. The Hilbert-Huang transform (HHT technique is further synthesized for online tuning of the controller gain adaptively to track the cable vibration evolution, which also obviates the iterative optimal gain selection for the trade-off between control performance and energy in the conventional time domain LQG (T-LQG control. The developed adaptive frequency-shaped LQG (AF-LQG control is realized by collocated self-sensing magnetorheological (MR dampers considering the nonlinear damper dynamics for force tracking control. Performance of the AF-LQG control is numerically validated on a bridge cable transversely attached with a self-sensing MR damper. The results demonstrate the adaptivity in gain tuning of the AF-LQG control to target for the dominant cable mode for vibration energy dissipation, as well as its enhanced control efficacy over the optimal passive MR damping control and the T-LQG control for different excitation modes and damper locations.

  6. Packed domain Rayleigh-Sommerfeld wavefield propagation for large targets.

    Science.gov (United States)

    Wuttig, Andreas; Kanka, Mario; Kreuzer, Hans Jürgen; Riesenberg, Rainer

    2010-12-20

    For applications in the domain of digital holographic microscopy, we present a fast algorithm to propagate scalar wave fields from a small source area to an extended, parallel target area of coarser sampling pitch, using the first Rayleigh-Sommerfeld diffraction formula. Our algorithm can take full advantage of the fast Fourier transform by decomposing the convolution kernel of the propagation into several convolution kernel patches. Using partial overlapping of the patches together with a soft blending function, the Fourier spectrum of these patches can be reduced to a low number of significant components, which can be stored in a compact sparse array structure. This allows for rapid evaluation of the partial convolution results by skipping over negligible components through the Fourier domain pointwise multiplication and direct mapping of the remaining multiplication results into a Fourier domain representation of the coarsly sampled target patch. The algorithm has been verified experimentally at a numerical aperture of 0.62, not showing any significant resolution limitations.

  7. Fourier phase in Fourier-domain optical coherence tomography

    Science.gov (United States)

    Uttam, Shikhar; Liu, Yang

    2015-01-01

    Phase of an electromagnetic wave propagating through a sample-of-interest is well understood in the context of quantitative phase imaging in transmission-mode microscopy. In the past decade, Fourier-domain optical coherence tomography has been used to extend quantitative phase imaging to the reflection-mode. Unlike transmission-mode electromagnetic phase, however, the origin and characteristics of reflection-mode Fourier phase are poorly understood, especially in samples with a slowly varying refractive index. In this paper, the general theory of Fourier phase from first principles is presented, and it is shown that Fourier phase is a joint estimate of subresolution offset and mean spatial frequency of the coherence-gated sample refractive index. It is also shown that both spectral-domain phase microscopy and depth-resolved spatial-domain low-coherence quantitative phase microscopy are special cases of this general theory. Analytical expressions are provided for both, and simulations are presented to explain and support the theoretical results. These results are further used to show how Fourier phase allows the estimation of an axial mean spatial frequency profile of the sample, along with depth-resolved characterization of localized optical density change and sample heterogeneity. Finally, a Fourier phase-based explanation of Doppler optical coherence tomography is also provided. PMID:26831383

  8. Fourier phase in Fourier-domain optical coherence tomography.

    Science.gov (United States)

    Uttam, Shikhar; Liu, Yang

    2015-12-01

    Phase of an electromagnetic wave propagating through a sample-of-interest is well understood in the context of quantitative phase imaging in transmission-mode microscopy. In the past decade, Fourier-domain optical coherence tomography has been used to extend quantitative phase imaging to the reflection-mode. Unlike transmission-mode electromagnetic phase, however, the origin and characteristics of reflection-mode Fourier phase are poorly understood, especially in samples with a slowly varying refractive index. In this paper, the general theory of Fourier phase from first principles is presented, and it is shown that Fourier phase is a joint estimate of subresolution offset and mean spatial frequency of the coherence-gated sample refractive index. It is also shown that both spectral-domain phase microscopy and depth-resolved spatial-domain low-coherence quantitative phase microscopy are special cases of this general theory. Analytical expressions are provided for both, and simulations are presented to explain and support the theoretical results. These results are further used to show how Fourier phase allows the estimation of an axial mean spatial frequency profile of the sample, along with depth-resolved characterization of localized optical density change and sample heterogeneity. Finally, a Fourier phase-based explanation of Doppler optical coherence tomography is also provided.

  9. Impact of domain analysis on reuse methods

    Science.gov (United States)

    Gilroy, Kathy

    1989-01-01

    The SPS is performing a study for the U.S. Army CECOM on the impact of domain analysis on reuse methods. Domain analysis is the first activity that should be performed in the development of reusable software. It identifies the commonalities between systems within a given problem (such as navigation systems or database management). In the software arena these commonalities are implemented as software components that can be reused by new systems within that application domain. The objectives of the study are to develop an approach that makes domain analysis practical and effective for the Army, to reinforce the importance of domain analysis for software reuse programs, and to summarize and coalesce domain analysis information into a single reference source. Existing methods and tools are being analyzed, critical issues identified, and key automation issues addressed. Based on these, a methodology and set of guidelines for domain analysis are being developed. Potential automated tools will be identified for each activity in the methodology.

  10. Penerapan Microskills dalam Domain Multicultural

    Directory of Open Access Journals (Sweden)

    Happy Karlina Marjo

    2013-03-01

    Full Text Available Konselor multikultural menggunakan microskills yang bertujuan untuk memodifikasi interaksi konselor dalam membuat perbedaan yang signifikan pada kehidupan konseli dengan: (1 mengidentifikasi faktor-faktor dari respon nonverbal untuk diri konselor sendiri dan konseli, (2 memahami dasar intervieu microskills dalam proses menerima (attending, mendengarkan (listening, dan mempengaruhi (influencing, serta dampak potensial pada konseli untuk berubah, (3 mencatat fokus microskills, dan perhatian secara selektif yang merupakan dasar untuk masalah keluarga dan konseling multikultural, (4 mengetahui bagaimana dan kapan menggunakan konfrontasi microskill, dan (5 mengetahui keterampilan intervieu sebagai acuan frame multikultural. Sedangkan domain kompetensi konseling multikultural untuk pendidikan dan praktek, antara lain: (1 Counselor Awareness of Own Cultural Values and Biases, (2 Counselor Awareness of Client’ Worldview, dan (3 Culturally Appropriate Intervention Strategies.

  11. Optimising predictor domains for spatially coherent precipitation downscaling

    Science.gov (United States)

    Radanovics, S.; Vidal, J.-P.; Sauquet, E.; Ben Daoud, A.; Bontron, G.

    2012-04-01

    resulting optimised domains are analysed for defining regions where neighbouring zones have equal or similar predictor domains and identifying which French river basins contain zones associated with different predictor domains, i.e. are exposed to different meteorological influences. The above analysis will be used (1) to extend the statistical downscaling method of Ben Daoud et al. (2011) to the whole of France and (2) to develop it further in order to achieve spatially coherent forecasts while preserving the predictive skill on the local scale. Ben Daoud, A., Sauquet, E., Lang, M., Bontron, G., and Obled, C. (2011). Precipitation forecasting through an analog sorting technique: a comparative study. Advances in Geosciences, 29:103-107. doi: 10.5194/adgeo-29-103-2011 Obled, C., Bontron, G., and Garçon, R. (2002). Quantitative precipitation forecasts: a statistical adaptation of model outputs through an analogues sorting approach. Atmospheric Research, 63(3-4):303-324. doi: 10.1016/S0169-8095(02)00038-8 Vidal, J.-P., Martin, E., Franchistéguy, L., Baillon, M., and Soubeyroux, J.-M. (2010) A 50-year high-resolution atmospheric reanalysis over France with the Safran system. International Journal of Climatology, 30:1627-1644. doi: 10.1002/joc.2003

  12. Time-Domain Convolutive Blind Source Separation Employing Selective-Tap Adaptive Algorithms

    Directory of Open Access Journals (Sweden)

    Pan Qiongfeng

    2007-01-01

    Full Text Available We investigate novel algorithms to improve the convergence and reduce the complexity of time-domain convolutive blind source separation (BSS algorithms. First, we propose MMax partial update time-domain convolutive BSS (MMax BSS algorithm. We demonstrate that the partial update scheme applied in the MMax LMS algorithm for single channel can be extended to multichannel time-domain convolutive BSS with little deterioration in performance and possible computational complexity saving. Next, we propose an exclusive maximum selective-tap time-domain convolutive BSS algorithm (XM BSS that reduces the interchannel coherence of the tap-input vectors and improves the conditioning of the autocorrelation matrix resulting in improved convergence rate and reduced misalignment. Moreover, the computational complexity is reduced since only half of the tap inputs are selected for updating. Simulation results have shown a significant improvement in convergence rate compared to existing techniques.

  13. Time-Domain Convolutive Blind Source Separation Employing Selective-Tap Adaptive Algorithms

    Directory of Open Access Journals (Sweden)

    Qiongfeng Pan

    2007-04-01

    Full Text Available We investigate novel algorithms to improve the convergence and reduce the complexity of time-domain convolutive blind source separation (BSS algorithms. First, we propose MMax partial update time-domain convolutive BSS (MMax BSS algorithm. We demonstrate that the partial update scheme applied in the MMax LMS algorithm for single channel can be extended to multichannel time-domain convolutive BSS with little deterioration in performance and possible computational complexity saving. Next, we propose an exclusive maximum selective-tap time-domain convolutive BSS algorithm (XM BSS that reduces the interchannel coherence of the tap-input vectors and improves the conditioning of the autocorrelation matrix resulting in improved convergence rate and reduced misalignment. Moreover, the computational complexity is reduced since only half of the tap inputs are selected for updating. Simulation results have shown a significant improvement in convergence rate compared to existing techniques.

  14. Thermodynamic Products in the Extended Phase Space

    CERN Document Server

    Pradhan, Parthapratim

    2016-01-01

    We have examined the thermodynamic properties of spherically symmetric charged-AdS black hole, charged AdS BH surrounded by quintessence and charged AdS BH in $f(R)$ gravity in the extended phase-space. Where the cosmological constant should be treated as thermodynamic pressure and its conjugate parameter as thermodynamic volume. Then they should behave as a analog of Van der Waal like systems. In the extended phase space we have calculated the \\emph{entropy product} and \\emph{thermodynamic volume product} of all horizons. The mass(or enthalpy) independent nature of the said products signals they are "universal" quantities. Various types of pictorial diagram of the specific heat is given. The divergence of the specific heat indicates that the second order phase transition occurs under certain condition.

  15. Optimizing Extender Code for NCSX Analyses

    Energy Technology Data Exchange (ETDEWEB)

    M. Richman, S. Ethier, and N. Pomphrey

    2008-01-22

    Extender is a parallel C++ code for calculating the magnetic field in the vacuum region of a stellarator. The code was optimized for speed and augmented with tools to maintain a specialized NetCDF database. Two parallel algorithms were examined. An even-block work-distribution scheme was comparable in performance to a master-slave scheme. Large speedup factors were achieved by representing the plasma surface with a spline rather than Fourier series. The accuracy of this representation and the resulting calculations relied on the density of the spline mesh. The Fortran 90 module db access was written to make it easy to store Extender output in a manageable database. New or updated data can be added to existing databases. A generalized PBS job script handles the generation of a database from scratch

  16. Junction conditions in extended Teleparallel gravities

    Energy Technology Data Exchange (ETDEWEB)

    De la Cruz-Dombriz, Álvaro [Departamento de Física Teórica I, Ciudad Universitaria, Universidad Complutense de Madrid, E-28040 Madrid (Spain); Dunsby, Peter K.S.; Sáez-Gómez, Diego, E-mail: dombriz@fis.ucm.es, E-mail: peter.dunsby@uct.ac.za, E-mail: diego.saezgomez@uct.ac.za [Astrophysics, Cosmology and Gravity Centre (ACGC), Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701, Cape Town (South Africa)

    2014-12-01

    In the context of extended Teleparallel gravity theories, we address the issue of junction conditions required to guarantee the correct matching of different regions of spacetime. In the absence of shells/branes, these conditions turn out to be more restrictive than their counterparts in General Relativity as in other extended theories of gravity. In fact, the general junction conditions on the matching hypersurfaces depend on the underlying theory and a new condition on the induced tetrads in order to avoid delta-like distributions in the field equations. This result imposes strict consequences on the viability of standard solutions such as the Einstein-Straus-like construction. We find that the continuity of the scalar torsion is required in order to recover the usual General Relativity results.

  17. Does string theory lead to extended inflation?

    Science.gov (United States)

    Campbell, Bruce A.; Linde, Andrei; Olive, Keith A.

    1991-05-01

    We consider the relationship between string theory and currently proposed models of extended inflation. In doing so, we discuss the conformal actions in string theory and in Jordan-Brans-Dicke gravity. We show explicitly the equivalence of pictures in which either gauge or gravitational couplings are changing with time. We demonstrate that the existence of the dilation in string theory does not naturally lead to extended inflation as currently discussed. We also discuss the resolution of the graceful exit problem of old inflation in Einstein gravity using either power-law inflation, or exponential inflation with a changing bubble formation rate. On leave of absence from School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, USA.

  18. Application of electron closures in extended MHD

    Science.gov (United States)

    Held, Eric; Adair, Brett; Taylor, Trevor

    2017-10-01

    Rigorous closure of the extended MHD equations in plasma fluid codes includes the effects of electron heat conduction along perturbed magnetic fields and contributions of the electron collisional friction and stress to the extended Ohms law. In this work we discuss application of a continuum numerical solution to the Chapman-Enskog-like electron drift kinetic equation using the NIMROD code. The implementation is a tightly-coupled fluid/kinetic system that carefully addresses time-centering in the advance of the fluid variables with their kinetically-computed closures. Comparisons of spatial accuracy, computational efficiency and required velocity space resolution are presented for applications involving growing magnetic islands in cylindrical and toroidal geometry. The reduction in parallel heat conduction due to particle trapping in toroidal geometry is emphasized. Work supported by DOE under Grant Nos. DE-FC02-08ER54973 and DE-FG02-04ER54746.

  19. Extending applicability of bimetric theory: chameleon bigravity

    Science.gov (United States)

    De Felice, Antonio; Mukohyama, Shinji; Uzan, Jean-Philippe

    2018-02-01

    This article extends bimetric formulations of massive gravity to make the mass of the graviton to depend on its environment. This minimal extension offers a novel way to reconcile massive gravity with local tests of general relativity without invoking the Vainshtein mechanism. On cosmological scales, it is argued that the model is stable and that it circumvents the Higuchi bound, hence relaxing the constraints on the parameter space. Moreover, with this extension the strong coupling scale is also environmentally dependent in such a way that it is kept sufficiently higher than the expansion rate all the way up to the very early universe, while the present graviton mass is low enough to be phenomenologically interesting. In this sense the extended bigravity theory serves as a partial UV completion of the standard bigravity theory. This extension is very generic and robust and a simple specific example is described.

  20. Extended range interferometry based on wavefront shaping

    Science.gov (United States)

    Szczupak, M. L.; Salbut, L.

    2007-09-01

    There are many cases when absolute measurements of objects with large height differences or height discontinuity is needed. These measurements can not be covered by classical interferometry since the range of non-ambiguity is limited to half the optical wavelength. Several techniques have been already developed for extending of non-ambiguity range. However most of them is based on multi-wavelength methods which demands expensive light sources and special environment conditions. In this work the new interferometric technique for absolute measurements of large steps discontinuities is proposed. Variable wavefront of the illuminating beam and special procedure for calibration of the measurement volume are used for extending of the measurement range without using multispectral sources. Additionally, calibration of the measurement area simplifies fringe processing and quicken measures. Theoretical analysis of this technique, its numerical simulations and experimental verification are presented and discussed.

  1. Structure and Function of KH Domains

    Energy Technology Data Exchange (ETDEWEB)

    Valverde, R.; Regan, E

    2008-01-01

    The hnRNP K homology (KH) domain was first identified in the protein human heterogeneous nuclear ribonucleoprotein K (hnRNP K) 14 years ago. Since then, KH domains have been identified as nucleic acid recognition motifs in proteins that perform a wide range of cellular functions. KH domains bind RNA or ssDNA, and are found in proteins associated with transcriptional and translational regulation, along with other cellular processes. Several diseases, e.g. fragile X mental retardation syndrome and paraneoplastic disease, are associated with the loss of function of a particular KH domain. Here we discuss the progress made towards understanding both general and specific features of the molecular recognition of nucleic acids by KH domains. The typical binding surface of KH domains is a cleft that is versatile but that can typically accommodate only four unpaired bases. Van der Waals forces and hydrophobic interactions and, to a lesser extent, electrostatic interactions, contribute to the nucleic acid binding affinity. 'Augmented' KH domains or multiple copies of KH domains within a protein are two strategies that are used to achieve greater affinity and specificity of nucleic acid binding. Isolated KH domains have been seen to crystallize as monomers, dimers and tetramers, but no published data support the formation of noncovalent higher-order oligomers by KH domains in solution. Much attention has been given in the literature to a conserved hydrophobic residue (typically Ile or Leu) that is present in most KH domains. The interest derives from the observation that an individual with this Ile mutated to Asn, in the KH2 domain of fragile X mental retardation protein, exhibits a particularly severe form of the syndrome. The structural effects of this mutation in the fragile X mental retardation protein KH2 domain have recently been reported. We discuss the use of analogous point mutations at this position in other KH domains to dissect both structure and

  2. Lepton flavor violation in an extended MSSM

    CERN Document Server

    Espinosa-Castañeda, R.; Gómez-Bock, M.; Mondragón, M.

    2016-01-01

    In this work we explore a lepton flavor violation effect induced at one loop for a flavor structure in an extended minimal standard supersymmetric model, considering an ansatz for the trilinear term. In particular we find a finite expression which will show the impact of this phenomena in the $h\\to \\mu \\tau$ decay, produced by a mixing in the trilinear coupling of the soft supersymmetric Lagrangian.

  3. Extended Deterministic Mean-Field Games

    KAUST Repository

    Gomes, Diogo A.

    2016-04-21

    In this paper, we consider mean-field games where the interaction of each player with the mean field takes into account not only the states of the players but also their collective behavior. To do so, we develop a random variable framework that is particularly convenient for these problems. We prove an existence result for extended mean-field games and establish uniqueness conditions. In the last section, we consider the Master Equation and discuss properties of its solutions.

  4. Deterministic automata for extended regular expressions

    Directory of Open Access Journals (Sweden)

    Syzdykov Mirzakhmet

    2017-12-01

    Full Text Available In this work we present the algorithms to produce deterministic finite automaton (DFA for extended operators in regular expressions like intersection, subtraction and complement. The method like “overriding” of the source NFA(NFA not defined with subset construction rules is used. The past work described only the algorithm for AND-operator (or intersection of regular languages; in this paper the construction for the MINUS-operator (and complement is shown.

  5. Interacting Holstein and extended-Holstein bipolarons

    OpenAIRE

    Chakraborty, Monodeep; Tezuka, Masaki; Min, B. I.

    2013-01-01

    Employing the recently developed self-consistent variational basis generation scheme, we have investigated the bipolaron-bipolaron interaction within the purview of Holstein-Hubbard and the extended-Holstein-Hubbard (F2H) model on a discrete one-dimensional lattice. The density-matrix renormalization group (DMRG) method has also been used for the Holstein-Hubbard model. We have shown that there exists no bipolaron-bipolaron attraction in the Holstein-Hubbard model. In contrast, we have obtain...

  6. The renewable tradition (extended play remix

    Directory of Open Access Journals (Sweden)

    Mark Amerika

    2009-12-01

    Full Text Available Drawing from a network of appropriation artists, process philosophers, performance poets, pla(ygiarists, and other remix provocateurs, this experimental artist essay investigates the act of remixologically inhabiting the body language of others and, in the process, devises an aesthetic theory that situates the contemporary artist as a "postproduction medium" whose methodologies further extend avant-garde practice into the 21st century.

  7. Extending DUNE: The dune-xt modules

    OpenAIRE

    Leibner, Tobias; Milk, René; Schindler, Felix

    2016-01-01

    We present our effort to extend and complement the core modules of the Distributed and Unified Numerics Environment DUNE (http://dune-project.org) by a well tested and structured collection of utilities and concepts. We describe key elements of our four modules dune-xt-common, dune-xt-grid, dune-xt-la and dune-xt-functions, which aim at further enabling the programming of generic algorithms within DUNE as well as adding an extra layer of usability and convenience.

  8. FRW Cosmology with the Extended Chaplygin Gas

    Directory of Open Access Journals (Sweden)

    B. Pourhassan

    2014-01-01

    Full Text Available We propose extended Chaplygin gas equation of state for which it recovers barotropic fluid with quadratic equation of state. We use numerical method to investigate the behavior of some cosmological parameters such as scale factor, Hubble expansion parameter, energy density, and deceleration parameter. We also discuss the resulting effective equation of state parameter. Using density perturbations we investigate the stability of the theory.

  9. Socially extended intentions-in-action

    DEFF Research Database (Denmark)

    Blomberg, Olle

    2011-01-01

    . Tollefsen’s account is specifically constructed to account for the joint activities of infants and toddlers who lack the capacity to think of others as planning agents and grasp their plan-like intentions (a capacity required by Michael Bratman’s (1992, 1993, 2009a, 2009b) influential account of joint...... activity). At the end of the paper, I raise some doubts regarding the extent to which infants and toddlers have socially extended intentions-in-action....

  10. Fusion Rules for Extended Current Algebras

    OpenAIRE

    Baver, Ernest; Gepner, Doron

    1996-01-01

    The initial classification of fusion rules have shown that rational conformal field theory is very limited. In this paper we study the fusion rules of extend ed current algebras. Explicit formulas are given for the S matrix and the fusion rules, based on the full splitting of the fixed point fields. We find that in s ome cases sensible fusion rules are obtained, while in others this procedure lea ds to fractional fusion constants.

  11. Stochastic population dynamics in spatially extended predator–prey systems

    Science.gov (United States)

    Dobramysl, Ulrich; Mobilia, Mauro; Pleimling, Michel; Täuber, Uwe C.

    2018-02-01

    complex Ginzburg–Landau equation. Multiple-species extensions to general ‘food networks’ can be classified on the mean-field level, providing both fundamental understanding of ensuing cooperativity and profound insight into the rich spatio-temporal features and coarsening kinetics in the corresponding spatially extended systems. Novel space-time patterns emerge as a result of the formation of competing alliances; e.g. coarsening domains that each incorporate rock-paper-scissors competition games.

  12. Thermodynamic volume and the extended Smarr relation

    Science.gov (United States)

    Hyun, Seungjoon; Jeong, Jaehoon; Park, Sang-A.; Yi, Sang-Heon

    2017-04-01

    We continue to explore the scaling transformation in the reduced action formalism of gravity models. As an extension of our construction, we consider the extended forms of the Smarr relation for various black holes, adopting the cosmological constant as the bulk pressure as in some literatures on black holes. Firstly, by using the quasi-local formalism for charges, we show that, in a general theory of gravity, the volume in the black hole thermodynamics could be defined as the thermodynamic conjugate variable to the bulk pressure in such a way that the first law can be extended consistently. This, so called, thermodynamic volume can be expressed explicitly in terms of the metric and field variables. Then, by using the scaling transformation allowed in the reduced action formulation, we obtain the extended Smarr relation involving the bulk pressure and the thermodynamic volume. In our approach, we do not resort to Euler's homogeneous scaling of charges while incorporating the would-be hairy contribution without any difficulty.

  13. A GPU-accelerated extended Kalman filter

    Science.gov (United States)

    Wei, Shih-Chieh; Huang, Bormin

    2011-11-01

    The extended Kalman filter is one of the most widely used techniques for state estimation of nonlinear systems. In its two steps of forecast and data assimilation, many matrix operations including multiplication and inversion are involved. As recent graphic processor units (GPU) have shown to provide much speedup in matrix operations, we will explore in this work a GPU-based implementation of the extended Kalman filter. The Compute Unified Device Architecture (CUDA) on the Nvidia GeForce GTX 590 GPU hardware will be used for comparison with a single threaded CPU counterpart. Experiments were conducted on typical large-scale over-determined systems with thousands of components in states and measurements. Within the GPU memory limit, a speedup of 1386x is achieved for a system with measurements having 5000 components and states having 3750 components. The speedup profile for various combinations of measurement and state sizes will serve as good reference for future implementation of extended Kalman filter on real large-scale applications.

  14. Why an extended evolutionary synthesis is necessary.

    Science.gov (United States)

    Müller, Gerd B

    2017-10-06

    Since the last major theoretical integration in evolutionary biology-the modern synthesis (MS) of the 1940s-the biosciences have made significant advances. The rise of molecular biology and evolutionary developmental biology, the recognition of ecological development, niche construction and multiple inheritance systems, the '-omics' revolution and the science of systems biology, among other developments, have provided a wealth of new knowledge about the factors responsible for evolutionary change. Some of these results are in agreement with the standard theory and others reveal different properties of the evolutionary process. A renewed and extended theoretical synthesis, advocated by several authors in this issue, aims to unite pertinent concepts that emerge from the novel fields with elements of the standard theory. The resulting theoretical framework differs from the latter in its core logic and predictive capacities. Whereas the MS theory and its various amendments concentrate on genetic and adaptive variation in populations, the extended framework emphasizes the role of constructive processes, ecological interactions and systems dynamics in the evolution of organismal complexity as well as its social and cultural conditions. Single-level and unilinear causation is replaced by multilevel and reciprocal causation. Among other consequences, the extended framework overcomes many of the limitations of traditional gene-centric explanation and entails a revised understanding of the role of natural selection in the evolutionary process. All these features stimulate research into new areas of evolutionary biology.

  15. Extended pie menus for immersive virtual environments.

    Science.gov (United States)

    Gebhardt, Sascha; Pick, Sebastian; Leithold, Franziska; Hentschel, Bernd; Kuhlen, Torsten

    2013-04-01

    Pie menus are a well-known technique for interacting with 2D environments and so far a large body of research documents their usage and optimizations. Yet, comparatively little research has been done on the usability of pie menus in immersive virtual environments (IVEs). In this paper we reduce this gap by presenting an implementation and evaluation of an extended hierarchical pie menu system for IVEs that can be operated with a six-degrees-of-freedom input device. Following an iterative development process, we first developed and evaluated a basic hierarchical pie menu system. To better understand how pie menus should be operated in IVEs, we tested this system in a pilot user study with 24 participants and focus on item selection. Regarding the results of the study, the system was tweaked and elements like check boxes, sliders, and color map editors were added to provide extended functionality. An expert review with five experts was performed with the extended pie menus being integrated into an existing VR application to identify potential design issues. Overall results indicated high performance and efficient design.

  16. Extended Self Similarity in Solar Wind Turbulence

    Science.gov (United States)

    Rowlands, G.; Chapman, S. C.; Hnat, B.

    2005-12-01

    The solar wind provides a natural laboratory for observations of MHD turbulence over extended temporal scales. A hallmark of turbulence is scaling- and scaling in the Probability Density Functions (PDF) of fluctuations in certain solar wind in- situ bulk plasma parameters has been established from WIND and ACE observations on `short' timescales up to a few hours. On longer timescales there is a crossover in scaling to uncorrelated behaviour. The intermittency of the system is expressed in these parameters through the non-Gaussian nature of the fluctuations PDF up to this timescale. Here we apply a generic approach to turbulence- that of Extended Self Similarity (ESS)- to the analysis of solar wind observations. We find that ESS can extend the range of scaling and for some parameters reveals two distinct scaling regions for the `short' and long timescales, whereas for others, a single scaling encompasses the behaviour over the full range of timescales. That certain parameters, and conditions, can be distinguished via ESS may provide physical insight into the turbulent solar wind.

  17. Prediction of Cancer Proteins by Integrating Protein Interaction, Domain Frequency, and Domain Interaction Data Using Machine Learning Algorithms

    Directory of Open Access Journals (Sweden)

    Chien-Hung Huang

    2015-01-01

    Full Text Available Many proteins are known to be associated with cancer diseases. It is quite often that their precise functional role in disease pathogenesis remains unclear. A strategy to gain a better understanding of the function of these proteins is to make use of a combination of different aspects of proteomics data types. In this study, we extended Aragues’s method by employing the protein-protein interaction (PPI data, domain-domain interaction (DDI data, weighted domain frequency score (DFS, and cancer linker degree (CLD data to predict cancer proteins. Performances were benchmarked based on three kinds of experiments as follows: (I using individual algorithm, (II combining algorithms, and (III combining the same classification types of algorithms. When compared with Aragues’s method, our proposed methods, that is, machine learning algorithm and voting with the majority, are significantly superior in all seven performance measures. We demonstrated the accuracy of the proposed method on two independent datasets. The best algorithm can achieve a hit ratio of 89.4% and 72.8% for lung cancer dataset and lung cancer microarray study, respectively. It is anticipated that the current research could help understand disease mechanisms and diagnosis.

  18. Dark energy and extended dark matter halos

    Science.gov (United States)

    Chernin, A. D.; Teerikorpi, P.; Valtonen, M. J.; Dolgachev, V. P.; Domozhilova, L. M.; Byrd, G. G.

    2012-03-01

    The cosmological mean matter (dark and baryonic) density measured in the units of the critical density is Ωm = 0.27. Independently, the local mean density is estimated to be Ωloc = 0.08-0.23 from recent data on galaxy groups at redshifts up to z = 0.01-0.03 (as published by Crook et al. 2007, ApJ, 655, 790 and Makarov & Karachentsev 2011, MNRAS, 412, 2498). If the lower values of Ωloc are reliable, as Makarov & Karachentsev and some other observers prefer, does this mean that the Local Universe of 100-300 Mpc across is an underdensity in the cosmic matter distribution? Or could it nevertheless be representative of the mean cosmic density or even be an overdensity due to the Local Supercluster therein. We focus on dark matter halos of groups of galaxies and check how much dark mass the invisible outer layers of the halos are able to host. The outer layers are usually devoid of bright galaxies and cannot be seen at large distances. The key factor which bounds the size of an isolated halo is the local antigravity produced by the omnipresent background of dark energy. A gravitationally bound halo does not extend beyond the zero-gravity surface where the gravity of matter and the antigravity of dark energy balance, thus defining a natural upper size of a system. We use our theory of local dynamical effects of dark energy to estimate the maximal sizes and masses of the extended dark halos. Using data from three recent catalogs of galaxy groups, we show that the calculated mass bounds conform with the assumption that a significant amount of dark matter is located in the invisible outer parts of the extended halos, sufficient to fill the gap between the observed and expected local matter density. Nearby groups of galaxies and the Virgo cluster have dark halos which seem to extend up to their zero-gravity surfaces. If the extended halo is a common feature of gravitationally bound systems on scales of galaxy groups and clusters, the Local Universe could be typical or even

  19. Extending the application of DSAM to atypical stopping media

    Energy Technology Data Exchange (ETDEWEB)

    Das, S.; Samanta, S.; Bhattacharjee, R. [UGC-DAE Consortium for Scientific Research, Kolkata Centre, Kolkata 700098 (India); Raut, R., E-mail: rraut@alpha.iuc.res.in [UGC-DAE Consortium for Scientific Research, Kolkata Centre, Kolkata 700098 (India); Ghugre, S.S. [UGC-DAE Consortium for Scientific Research, Kolkata Centre, Kolkata 700098 (India); Sinha, A.K. [UGC-DAE Consortium for Scientific Research, Indore 452001 (India); Garg, U. [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Chakrabarti, R.; Mukhopadhyay, S. [Nuclear Physics Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Dhal, A.; Raju, M. Kumar; Madhavan, N.; Muralithar, S.; Singh, R.P. [Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India); Suryanarayana, K.; Rao, P.V. Madhusudhana [Department of Nuclear Physics, Andhra University, Visakhapatnam 530003 (India); Palit, R.; Saha, S.; Sethi, J. [Tata Institute of Fundamental Research, Mumbai 400005 (India)

    2017-01-01

    A methodology that manifolds the possibilities of level lifetime measurements using the Doppler Shift Attenuation Method (DSAM), and extends its application beyond the conventional thin-target-on-thick-elemental-backing setups, is presented. This has been achieved primarily through application of the TRIM code to simulate the stopping of the recoils in the target and the backing media. Using the TRIM code, primarily adopted in the domain of materials research, in the context of lifetime analysis require rendition of the simulation results into a representation that appropriately incorporates the nuances of nuclear reaction along with the associated kinematics, besides the transformation from an energy-coordinate representation to a velocity-direction profile as required for lifetime analysis. The present development makes it possible to practice DSAM in atypical experimental scenarios such as those using molecular or multi-layered target and/or backing as the stopping medium. These aberrant cases, that were beyond representation in the customary Doppler shape analysis can, in the light of the present work, be conveniently used in the DSAM based investigations. The new approach has been validated through re-examination of known lifetimes measured both in the conventional as well as in the deviant setups.

  20. Extending large-scale forest inventories to assess urban forests.

    Science.gov (United States)

    Corona, Piermaria; Agrimi, Mariagrazia; Baffetta, Federica; Barbati, Anna; Chiriacò, Maria Vincenza; Fattorini, Lorenzo; Pompei, Enrico; Valentini, Riccardo; Mattioli, Walter

    2012-03-01

    Urban areas are continuously expanding today, extending their influence on an increasingly large proportion of woods and trees located in or nearby urban and urbanizing areas, the so-called urban forests. Although these forests have the potential for significantly improving the quality the urban environment and the well-being of the urban population, data to quantify the extent and characteristics of urban forests are still lacking or fragmentary on a large scale. In this regard, an expansion of the domain of multipurpose forest inventories like National Forest Inventories (NFIs) towards urban forests would be required. To this end, it would be convenient to exploit the same sampling scheme applied in NFIs to assess the basic features of urban forests. This paper considers approximately unbiased estimators of abundance and coverage of urban forests, together with estimators of the corresponding variances, which can be achieved from the first phase of most large-scale forest inventories. A simulation study is carried out in order to check the performance of the considered estimators under various situations involving the spatial distribution of the urban forests over the study area. An application is worked out on the data from the Italian NFI.

  1. Extended DBI massive gravity with generalized fiducial metric

    Energy Technology Data Exchange (ETDEWEB)

    Chullaphan, Tossaporn [The Institute for Fundamental Study, Naresuan University,Phitsanulok 65000 (Thailand); Department of Physics, Faculty of Science, Udon Thani Rajabhat University,Udon Thani 41000 (Thailand); Tannukij, Lunchakorn [Department of Physics, Faculty of Science, Mahidol University,Bangkok 10400 (Thailand); Wongjun, Pitayuth [The Institute for Fundamental Study, Naresuan University,Phitsanulok 65000 (Thailand); Thailand Center of Excellence in Physics, Ministry of Education,Bangkok 10400 (Thailand)

    2015-06-05

    We consider an extended model of DBI massive gravity by generalizing the fiducial metric to be an induced metric on the brane corresponding to a domain wall moving in five-dimensional Schwarzschild-Anti-de Sitter spacetime. The model admits all solutions of FLRW metric including flat, closed and open geometries while the original one does not. The background solutions can be divided into two branches namely self-accelerating branch and normal branch. For the self-accelerating branch, the graviton mass plays the role of cosmological constant to drive the late-time acceleration of the universe. It is found that the number degrees of freedom of gravitational sector is not correct similar to the original DBI massive gravity. There are only two propagating degrees of freedom from tensor modes. For normal branch, we restrict our attention to a particular class of the solutions which provides an accelerated expansion of the universe. It is found that the number of degrees of freedom in the model is correct. However, at least one of them is ghost degree of freedom which always present at small scale implying that the theory is not stable.

  2. Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.

    Science.gov (United States)

    Ke, Ying; Ng, Chai Ann; Hunter, Mark J; Mann, Stefan A; Heide, Juliane; Hill, Adam P; Vandenberg, Jamie I

    2013-08-15

    Loss of Kv11.1 potassium channel function is the underlying cause of pathology in long-QT syndrome type 2, one of the commonest causes of sudden cardiac death in the young. Previous studies have identified the cytosolic PAS (Per/Arnt/Sim) domain as a hotspot for mutations that cause Kv11.1 trafficking defects. To investigate the underlying basis of this observation, we have quantified the effect of mutants on domain folding as well as interactions between the PAS domain and the remainder of the channel. Apart from R56Q, all mutants impaired the thermostability of the isolated PAS domain. Six mutants, located in the vicinity of a hydrophobic patch on the PAS domain surface, also affected binding of the isolated PAS domain to an N-terminal truncated hERG (human ether-a-go-go-related gene) channel. Conversely, four other surface mutants (C64Y, T65P, A78P and I96T) and one buried mutant (L86R) did not prevent the isolated PAS domain binding to the truncated channels. Our results highlight a critical role for interactions between the PAS domain and the remainder of the channel in the hERG assembly and that mutants that affect PAS domain interactions with the remainder of the channel have a more severe trafficking defect than that caused by domain unfolding alone.

  3. Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases.

    Science.gov (United States)

    Miller, Bradley R; Sundlov, Jesse A; Drake, Eric J; Makin, Thomas A; Gulick, Andrew M

    2014-10-01

    Nonribosomal peptide synthetases (NRPSs) are multimodular proteins capable of producing important peptide natural products. Using an assembly line process, the amino acid substrate and peptide intermediates are passed between the active sites of different catalytic domains of the NRPS while bound covalently to a peptidyl carrier protein (PCP) domain. Examination of the linker sequences that join the NRPS adenylation and PCP domains identified several conserved proline residues that are not found in standalone adenylation domains. We examined the roles of these proline residues and neighboring conserved sequences through mutagenesis and biochemical analysis of the reaction catalyzed by the adenylation domain and the fully reconstituted NRPS pathway. In particular, we identified a conserved LPxP motif at the start of the adenylation-PCP linker. The LPxP motif interacts with a region on the adenylation domain to stabilize a critical catalytic lysine residue belonging to the A10 motif that immediately precedes the linker. Further, this interaction with the C-terminal subdomain of the adenylation domain may coordinate movement of the PCP with the conformational change of the adenylation domain. Through this work, we extend the conserved A10 motif of the adenylation domain and identify residues that enable proper adenylation domain function. © 2014 Wiley Periodicals, Inc.

  4. Extended overview techniques for outdoor augmented reality.

    Science.gov (United States)

    Veas, Eduardo; Grasset, Raphaël; Kruijff, Ernst; Schmalstieg, Dieter

    2012-04-01

    In this paper, we explore techniques that aim to improve site understanding for outdoor Augmented Reality (AR) applications. While the first person perspective in AR is a direct way of filtering and zooming on a portion of the data set, it severely narrows overview of the situation, particularly over large areas. We present two interactive techniques to overcome this problem: multi-view AR and variable perspective view. We describe in details the conceptual, visualization and interaction aspects of these techniques and their evaluation through a comparative user study. The results we have obtained strengthen the validity of our approach and the applicability of our methods to a large range of application domains.

  5. Extending family nursing: concepts from positive psychology.

    Science.gov (United States)

    Skerrett, Karen

    2010-11-01

    This article identifies the burgeoning field of positive psychology as an important extension to the knowledge base of family nursing. Representing a new emphasis from the traditional social and human sciences, which have largely focused on problem- and deficit-based approaches, positive psychology focuses on optimal functioning and is an ideal complement to the strengths-based orientation of family nursing. Domains of positive psychology are presented and exemplars of supporting research offered. Finally, suggestions are given for ways to apply concepts from positive psychology to family nursing practice, research, and education.

  6. Mapping arm-DNA-binding domain interactions in AraC.

    Science.gov (United States)

    Wu, M; Schleif, R

    2001-04-06

    AraC protein, the regulator of the l-arabinose operon in Escherichia coli has been postulated to function by a light switch mechanism. According to this mechanism, it should be possible to find mutations in the DNA-binding domain of AraC that result in weaker arm-DNA-binding domain interactions and which make the protein constitutive, that is, it no longer requires arabinose to activate transcription. We isolated such mutations by randomizing three contiguous leucine residues in the DNA-binding domain, and then by systematically scanning surface residues of the DNA-binding domain with alanine and glutamic acid. As a result, a total of 20 constitutive mutations were found at ten different positions. They form a contiguous trail on the DNA-distal face of the DNA-binding domain, and likely define the region where the N-terminal arm that extends from the N-terminal dimerization domain contacts the C-terminal DNA-binding domain. Copyright 2001 Academic Press.

  7. Structure of the Redox Sensor Domain of Methylococcus capsulatus (Bath) MmoS

    Energy Technology Data Exchange (ETDEWEB)

    Ukaegbu, Uchechi E.; Rosenzweig, Amy C.; (NWU)

    2009-06-01

    MmoS from Methylococcus capsulatus (Bath) is the multidomain sensor protein of a two-component signaling system proposed to play a role in the copper-mediated regulation of soluble methane monooxygenase (sMMO). MmoS binds an FAD cofactor within its N-terminal tandem Per-Arnt-Sim (PAS) domains, suggesting that it functions as a redox sensor. The crystal structure of the MmoS tandem PAS domains, designated PAS-A and PAS-B, has been determined to 2.34 {angstrom} resolution. Both domains adopt the typical PAS domain {alpha}/{beta} topology and are structurally similar. The two domains are linked by a long {alpha} helix and do not interact with one another. The FAD cofactor is housed solely within PAS-A and is stabilized by an extended hydrogen bonding network. The overall fold of PAS-A is similar to those of other flavin-containing PAS domains, but homodimeric interactions in other structures are not observed in the MmoS sensor, which crystallized as a monomer. The structure both provides new insight into the architecture of tandem PAS domains and suggests specific residues that may play a role in MmoS FAD redox chemistry and subsequent signal transduction.

  8. Structure of the redox sensor domain of Methylococcus capsulatus (Bath) MmoS‡

    Science.gov (United States)

    Ukaegbu, Uchechi E.; Rosenzweig, Amy C.

    2009-01-01

    MmoS from Methylococcus capsulatus (Bath) is the multidomain sensor protein of a two component signaling system proposed to play a role in the copper-mediated regulation of soluble methane monooxygenase (sMMO). MmoS binds an FAD cofactor within its N-terminal tandem Per-Arnt-Sim (PAS) domains, suggesting that it functions as a redox sensor. The crystal structure of the MmoS tandem PAS domains, designated PAS-A and PAS-B, has been determined to 2.34 Å resolution. Both domains adopt the typical PAS domain α/β topology and are structurally similar. The two domains are linked by a long α helix and do not interact with one another. The FAD cofactor is housed solely within PAS-A and is stabilized by an extended hydrogen bonding network. The overall fold of PAS-A is similar to other flavin-containing PAS domains, but homodimeric interactions in other structures are not observed in the MmoS sensor, which crystallized as a monomer. The structure both provides new insight into the architecture of tandem PAS domains and suggests specific residues that may play a role in MmoS FAD redox chemistry and subsequent signal transduction. PMID:19271777

  9. Structure of the redox sensor domain of Methylococcus capsulatus (Bath) MmoS.

    Science.gov (United States)

    Ukaegbu, Uchechi E; Rosenzweig, Amy C

    2009-03-17

    MmoS from Methylococcus capsulatus (Bath) is the multidomain sensor protein of a two-component signaling system proposed to play a role in the copper-mediated regulation of soluble methane monooxygenase (sMMO). MmoS binds an FAD cofactor within its N-terminal tandem Per-Arnt-Sim (PAS) domains, suggesting that it functions as a redox sensor. The crystal structure of the MmoS tandem PAS domains, designated PAS-A and PAS-B, has been determined to 2.34 A resolution. Both domains adopt the typical PAS domain alpha/beta topology and are structurally similar. The two domains are linked by a long alpha helix and do not interact with one another. The FAD cofactor is housed solely within PAS-A and is stabilized by an extended hydrogen bonding network. The overall fold of PAS-A is similar to those of other flavin-containing PAS domains, but homodimeric interactions in other structures are not observed in the MmoS sensor, which crystallized as a monomer. The structure both provides new insight into the architecture of tandem PAS domains and suggests specific residues that may play a role in MmoS FAD redox chemistry and subsequent signal transduction.

  10. Microbial F-type lectin domains with affinity for blood group antigens.

    Science.gov (United States)

    Mahajan, Sonal; Khairnar, Aasawari; Bishnoi, Ritika; Ramya, T N C

    2017-09-23

    F-type lectins are fucose binding lectins with characteristic fucose binding and calcium binding motifs. Although they occur with a selective distribution in viruses, prokaryotes and eukaryotes, most biochemical studies have focused on vertebrate F-type lectins. Recently, using sensitive bioinformatics search techniques on the non-redundant database, we had identified many microbial F-type lectin domains with diverse domain organizations. We report here the biochemical characterization of F-type lectin domains from Cyanobium sp. PCC 7001, Myxococcus hansupus and Leucothrix mucor. We demonstrate that while all these three microbial F-type lectin domains bind to the blood group H antigen epitope on fucosylated glycans, there are fine differences in their glycan binding specificity. Cyanobium sp. PCC 7001 F-type lectin domain binds exclusively to extended H type-2 motif, Myxococcus hansupus F-type lectin domain binds to B, H type-1 and Lewis(b) motifs, and Leucothrix mucor F-type lectin domain binds to a wide range of fucosylated glycans, including A, B, H and Lewis antigens. We believe that these microbial lectins will be useful additions to the glycobiologist's toolbox for labeling, isolating and visualizing glycans. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Comparison of Current and Field Driven Domain Wall Motion in Beaded Permalloy Nanowires

    Science.gov (United States)

    Lage, Enno; Dutta, Sumit; Ross, Caroline A.

    2015-03-01

    Domain wall based devices are promising candidates for non-volatile memory devices with no static power consumption. A common approach is the use of (field assisted) current driven domain wall motion in magnetic nanowires. In such systems local variations in linewidth act as obstacles for propagating domain walls. In this study we compare simulated field driven and current driven domain wall motion in permalloy nanowires with anti-notches. The simulations were obtained using the Object Oriented MicroMagnetics Framework (OOMMF). The wires with a constant thickness of 8 nm exhibit linewidths ranging from 40 nm to 300 nm. Circular shaped anti-notches extend the linewidth locally by 10% to 30% and raise information about the domain wall propagation in such beaded nanowires. The results are interpreted in terms of the observed propagation behavior and summarized in maps indicating ranges of different ability to overcome the pinning caused by anti-notches of different sizes. Furthermore, regimes of favored domain wall type (transverse walls or vortex walls) and complex propagation effects like walker breakdown behavior or dynamic change between domain wall structures are identified The authors thank the German Academic Exchange Service (DAAD) for funding.

  12. 20 CFR 336.15 - How to claim extended benefits.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false How to claim extended benefits. 336.15 Section 336.15 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT DURATION OF NORMAL AND EXTENDED BENEFITS Extended Benefits § 336.15 How to claim extended...

  13. 20 CFR 336.14 - Extended benefit period.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Extended benefit period. 336.14 Section 336.14 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT DURATION OF NORMAL AND EXTENDED BENEFITS Extended Benefits § 336.14 Extended benefit period...

  14. Comparison of different extenders and storage temperature on the ...

    African Journals Online (AJOL)

    Semen was pooled and randomly allocated to four groups and diluted at a ratio of 1:1 (v/v) with Beltsville thawing solution (BTS), Kobidil+, egg yolk citrate (EYC) and non-extended semen (Control). Each extender had two similar semen samples, making a total of eight samples. Extended and non-extended semen were ...

  15. On Domain Registries and Website Content

    DEFF Research Database (Denmark)

    Schwemer, Sebastian Felix

    2018-01-01

    The link of lawful domain names to unlawful content is a phenomenon that until recently has not been very topical. Traditionally, domain registries have been off the radar of content-related debates. Enforcement efforts, public discourse and academic research have focused on other intermediaries...... such as Internet access service providers, hosting platforms, and websites that link to content. This article shows that in recent years, however, that the (secondary) liability of domain registries and registrars, and more specifically country code top-level domain registries (ccTLDs) for website content, has...... been tested in several EU Member States. The article investigates tendencies in the national lower-court jurisprudence and explores to what extent the liability exemption regime of the E-Commerce Directive applies to domain registries. The analysis concludes that whereas domain registries fall under...

  16. Juridical Regime of the Public Domain

    Directory of Open Access Journals (Sweden)

    Vasilica Negruţ

    2009-06-01

    Full Text Available The goods that form the administrative domain are classified in two categories: some to whichthe private law rules can be applied, some others meant for public use, unliable of individual approach,forming the public domain. The term of juridical regime of the public domain has in view the assembly ofrules that can be applied to the goods belonging to the public domain as well as the juridical relations bornbetween the owners of these goods and third persons. The public property goods are subjected exclusivelyto a juridical regime by public law, while the private property goods belonging to the public domain aregoverned simultaneously by two types of juridical regimes and more exactly by a mixed juridical regimeby common right and by power. The principles that can be applied to the public domain goods are: theinalienability, the imprescriptibility and the imperceptibility.

  17. Domains in Ferroic Crystals and Thin Films

    CERN Document Server

    Tagantsev, Alexander K; Fousek, Jan

    2010-01-01

    Domains in Ferroic Crystals and Thin Films presents experimental findings and theoretical understanding of ferroic (non-magnetic) domains developed during the past 60 years. It addresses the situation by looking specifically at bulk crystals and thin films, with a particular focus on recently-developed microelectronic applications and methods for observation of domains with techniques such as scanning force microscopy, polarized light microscopy, scanning optical microscopy, electron microscopy, and surface decorating techniques. Domains in Ferroic Crystals and Thin Films covers a large area of material properties and effects connected with static and dynamic properties of domains, which are extremely relevant to materials referred to as ferroics. In most solid state physics books, one large group of ferroics is customarily covered: those in which magnetic properties play a dominant role. Numerous books are specifically devoted to magnetic ferroics and cover a wide spectrum of magnetic domain phenomena. In co...

  18. Optical time-domain mixer

    Science.gov (United States)

    Valley, George C.; Sefler, George A.

    2010-08-01

    We simulate an optical time-domain mixer that can be used to make a photonic analog-to-digital converter (ADC) or a digital demodulator for high-speed optical communications signals. In the basic mixer, a high frequency RF signal modulates a repetitively chirped optical carrier; this RF/optical waveform then is dispersed in one transverse dimension, and imaged onto a 2-dimensional transparency or spatial light modulator whose pixels are modulated with randomly chosen transmission or reflection coefficients (the optical mixing matrix). Following transmission through or reflection from the mixing matrix, the optical waveform from each row of the matrix is recombined and directed to a photodiode and electronics that integrate over the repetition period of the chirped source. Finally, each of these signals is digitized by an independent ADC sampling at a rate equal to the pulse repetition rate of the chirp source. A digital replica of the input RF signal can be recovered by digital signal processing from the digital output of the ADCs and the values of the transmission or reflection coefficients of the mixing matrix. The effective sampling rate is given by the number of pixels per row of the mixing matrix times the repetition rate of the chirp source while the effective resolution is controlled by the resolution of the electronic ADCs and the distortions introduced by the optical mixing process.

  19. Deformation of Entire Functions with Baker Domains

    DEFF Research Database (Denmark)

    Fagella, Nuria; Henriksen, Christian

    2006-01-01

    We consider entire transcendental functions f with an invariant (or periodic) Baker Domain. First, we classify these domains into three types (hyperbolic, simply parabolic and doubly parabolic) according to the surface they induce when we take the quotient by the dynamics. Second, we study the sp...... the space of quasiconformal deformations of an entire map with such a Baker Domain by studying its Teichmuller Space....

  20. Discovering Structure in the Moral Domain

    OpenAIRE

    Chakroff, Aleksandr

    2015-01-01

    Early moral psychologists identified the moral domain with a class of actions that negatively impacted the wellbeing of others or violated their rights. However, anthropological work suggested that this view failed to capture the full extent of the moral domain, which can include victimless actions (e.g., food taboos), especially among socially conservative or non-Western individuals. Which kinds of acts are included in the moral domain? Along which dimensions do the acts differ from one anot...

  1. Heterogeneous Multitask Metric Learning Across Multiple Domains.

    Science.gov (United States)

    Luo, Yong; Wen, Yonggang; Tao, Dacheng

    2017-10-04

    Distance metric learning plays a crucial role in diverse machine learning algorithms and applications. When the labeled information in a target domain is limited, transfer metric learning (TML) helps to learn the metric by leveraging the sufficient information from other related domains. Multitask metric learning (MTML), which can be regarded as a special case of TML, performs transfer across all related domains. Current TML tools usually assume that the same feature representation is exploited for different domains. However, in real-world applications, data may be drawn from heterogeneous domains. Heterogeneous transfer learning approaches can be adopted to remedy this drawback by deriving a metric from the learned transformation across different domains. However, they are often limited in that only two domains can be handled. To appropriately handle multiple domains, we develop a novel heterogeneous MTML (HMTML) framework. In HMTML, the metrics of all different domains are learned together. The transformations derived from the metrics are utilized to induce a common subspace, and the high-order covariance among the predictive structures of these domains is maximized in this subspace. There do exist a few heterogeneous transfer learning approaches that deal with multiple domains, but the high-order statistics (correlation information), which can only be exploited by simultaneously examining all domains, is ignored in these approaches. Compared with them, the proposed HMTML can effectively explore such high-order information, thus obtaining more reliable feature transformations and metrics. Effectiveness of our method is validated by the extensive and intensive experiments on text categorization, scene classification, and social image annotation.

  2. Extending the applicability of multigrid methods

    Energy Technology Data Exchange (ETDEWEB)

    Brannick, J; Brezina, M; Falgout, R; Manteuffel, T; McCormick, S; Ruge, J; Sheehan, B; Xu, J; Zikatanov, L

    2006-09-25

    Multigrid methods are ideal for solving the increasingly large-scale problems that arise in numerical simulations of physical phenomena because of their potential for computational costs and memory requirements that scale linearly with the degrees of freedom. Unfortunately, they have been historically limited by their applicability to elliptic-type problems and the need for special handling in their implementation. In this paper, we present an overview of several recent theoretical and algorithmic advances made by the TOPS multigrid partners and their collaborators in extending applicability of multigrid methods. Specific examples that are presented include quantum chromodynamics, radiation transport, and electromagnetics.

  3. Extending the applicability of multigrid methods

    Energy Technology Data Exchange (ETDEWEB)

    Brannick, J [Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309 (United States); Brezina, M [Center for Applied and Scientific Computing, Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Falgout, R [Center for Applied and Scientific Computing, Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Manteuffel, T [Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309 (United States); McCormick, S [Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309 (United States); Ruge, J [Department of Applied Mathematics, University of Colorado, Boulder, CO, 80309 (United States); Sheehan, B [Center for Applied and Scientific Computing, Lawrence Livermore National Laboratory, Livermore, CA 94551 (United States); Xu, J [Department of Mathematics, Pennsylvania State University, University Park, PA, 16802 (United States); Zikatanov, L [Department of Mathematics, Pennsylvania State University, University Park, PA, 16802 (United States)

    2006-09-15

    Multigrid methods are ideal for solving the increasingly large-scale problems that arise in numerical simulations of physical phenomena because of their potential for computational costs and memory requirements that scale linearly with the degrees of freedom. Unfortunately, they have been historically limited by their applicability to elliptic-type problems and the need for special handling in their implementation. In this paper, we present an overview of several recent theoretical and algorithmic advances made by the TOPS multigrid partners and their collaborators in extending applicability of multigrid methods. specific examples that are presented include quantum chromodynamics, radiation transport, and electromagnetics.

  4. Cambridge IGCSE mathematics core and extended

    CERN Document Server

    Pimentel, Ric

    2013-01-01

    The most cost effective and straightforward way to teach the revised syllabus, with all the core and extended content covered by a single book and accompanying free digital resources.  . This title has been written for the revised Cambridge IGCSE Mathematics (0580) syllabus, for first teaching from 2013.  . ·         Gives students the practice they require to deepen their understanding through plenty of questions. ·         Consolidates learning with unique digital resources on the CD, included free with every Student's Book.  . We are working with Cambridge International Examinations to gain

  5. Extended Carbon Cognition as a Machine

    DEFF Research Database (Denmark)

    Lippert, Ingmar

    2011-01-01

    . As a result of this analysis carbon accounting emerges as enabled through an extended system of cognition. The paper concludes by tentatively suggesting a view on this machinery as co-constituting a wider -- to borrow Guattari's term -- Universe: A Universe of references to carbon. Following these relations...... of thinking allows to question the conceptualisa- tions of the actors involved and how their practical interactions render carbon, nature and our society (un)sustainable. This, I hope, provides a chance to better conceptualise individuals, their social and material contexts, and through that, corresponding...

  6. Exploring Social Structures in Extended Team Model

    DEFF Research Database (Denmark)

    Zahedi, Mansooreh; Ali Babar, Muhammad

    2013-01-01

    Extended Team Model (ETM) as a type of offshore outsourcing is increasingly becoming popular mode of Global Software Development (GSD). There is little knowledge about the social structures in ETM and their impact on collaboration. Within a large interdisciplinary project to develop the next...... generation of GSD technologies, we are exploring the role of social structures to support collaboration. This paper reports some details of our research design and initial findings about the mechanisms to support social structures and their impact on collaboration in an ETM....

  7. Extended solutions for the biadjoint scalar field

    Science.gov (United States)

    De Smet, Pieter-Jan; White, Chris D.

    2017-12-01

    Biadjoint scalar field theories are increasingly important in the study of scattering amplitudes in various string and field theories. Recently, some first exact nonperturbative solutions of biadjoint scalar theory were presented, with a pure power-like form corresponding to isolated monopole-like objects located at the origin of space. In this paper, we find a novel family of extended solutions, involving non-trivial form factors that partially screen the divergent field at the origin. All previous solutions emerge as special cases.

  8. The eighth national electromagnetics meeting. Extended abstracts

    Energy Technology Data Exchange (ETDEWEB)

    Eloranta, E.; Jokela, K. [eds.

    1998-09-01

    The National Electromagnetics Meeting has been arranged annually since 1991 in Finland. The purpose of the meeting is to convene the persons working with problems of electromagnetics and to enhance the interaction between different research groups in different disciplines. The eighth meeting was held at the Radiation and Nuclear Safety Authority (STUK) August 27, 1998. The meeting is also the national meeting of the URSI (L`Union Radio-Scientifique Internationals)(Commission B: Fields and Waves) and the IEEE MTT/AP/ED Finland Chapter (Institute of Electrical and Electronics Engineers, Inc.). The report includes the extended abstracts of the presentations given in the National Electromagnetics Meeting at STUK. (orig.)

  9. An extended Farm Site Development Method

    Directory of Open Access Journals (Sweden)

    Eugene Hanekom

    2016-09-01

    Full Text Available The inefficient and ineffective use of arable land in South Africa is one of the numerous challenges within its agricultural sector. Previous research has indicated that a method, the Farm Site Development Method (FSDM, could increase the effective and efficient use of arable land by providing a roadmap to the farm owner for incrementally transforming the current state facilities and resources of a farm towards a future saturation state. The FSDM was then demonstrated at a crop-producing farm and several opportunities existed to extend its utility. Here we suggest its extension for application to a livestock farm, and also include optimisation techniques, demand planning and financial planning.

  10. Extending matchgates into universal quantum computation

    Energy Technology Data Exchange (ETDEWEB)

    Brod, Daniel J.; Galvao, Ernesto F. [Instituto de Fisica, Universidade Federal Fluminense, Av. Gal. Milton Tavares de Souza s/n, Gragoata, Niteroi, RJ, 24210-340 (Brazil)

    2011-08-15

    Matchgates are a family of two-qubit gates associated with noninteracting fermions. They are classically simulatable if acting only on nearest neighbors but become universal for quantum computation if we relax this restriction or use swap gates [Jozsa and Miyake, Proc. R. Soc. A 464, 3089 (2008)]. We generalize this result by proving that any nonmatchgate parity-preserving unitary is capable of extending the computational power of matchgates into universal quantum computation. We identify the single local invariant of parity-preserving unitaries responsible for this, and discuss related results in the context of fermionic systems.

  11. A closer look at racial differences in the reporting of self-assessed ...

    African Journals Online (AJOL)

    2011-10-05

    Oct 5, 2011 ... respect to the perception and reporting of SAH between members of different race groups in. South Africa. ... this study analysed racial differences in SAH alongside domain-specific SAH and attitudes ...... Charasse-Pouèlè, C. & Fournier, M., 2006, 'Health disparities between racial groups in South Africa: A ...

  12. Ferromagnetic stripe domains in ultrathin films

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, B. [Department of Secondary Science and Mathematics Education, University of Mersin, Yenisehir Campus, 33169 Mersin (Turkey)]. E-mail: bengukaplan@yahoo.com

    2005-03-01

    Using simple magnetostatic considerations, we discuss the domain structure and the domain-wall width, {omega}, in ultrathin magnetic films (of a few monolayer thickness) and in an atomic monolayer. The demagnetizing energy is calculated in a continuum theory which is valid provided that the domains are large compared with the lattice spacing. The calculated domain-wall width, {omega}, and the surface anisotropy constant, K{sub s}, are compared with the experimental data for thin epitaxial Co/Au (111) films and a good coincidence is obtained between both results.

  13. Planar domain walls in black hole spacetimes

    Science.gov (United States)

    Ficek, Filip; Mach, Patryk

    2018-02-01

    We investigate the behavior of low-mass, planar domain walls in the so-called ϕ4 model of the scalar field on the Schwarzschild and Kerr backgrounds. We focus on a transit of a domain wall through a black hole and solve numerically the equations of motion for a range of parameters of the domain wall and the black hole. We observe a behavior resembling an occurrence of ringing modes. Perturbations of domain walls vanish during latter evolution, suggesting their stability against a passage through the black hole. The results obtained for Kerr and Reissner-Nordström black holes are also compared.

  14. Sampling in the Linear Canonical Transform Domain

    Directory of Open Access Journals (Sweden)

    Bing-Zhao Li

    2012-01-01

    Full Text Available This paper investigates the interpolation formulae and the sampling theorem for bandpass signals in the linear canonical transform (LCT domain. Firstly, one of the important relationships between the bandpass signals in the Fourier domain and the bandpass signals in the LCT domain is derived. Secondly, two interpolation formulae from uniformly sampled points at half of the sampling rate associated with the bandpass signals and their generalized Hilbert transform or the derivatives in the LCT domain are obtained. Thirdly, the interpolation formulae from nonuniform samples are investigated. The simulation results are also proposed to verify the correctness of the derived results.

  15. Building the DAML Electronic Commerce Domain

    National Research Council Canada - National Science Library

    Anyiwo, David

    2001-01-01

    The project captured additional functional and technical requirements for collaboration and exchange in the electronics industry's value chain, and refined the eCommerce domain ontology requirements...

  16. Multiple graph regularized protein domain ranking

    Directory of Open Access Journals (Sweden)

    Wang Jim

    2012-11-01

    Full Text Available Abstract Background Protein domain ranking is a fundamental task in structural biology. Most protein domain ranking methods rely on the pairwise comparison of protein domains while neglecting the global manifold structure of the protein domain database. Recently, graph regularized ranking that exploits the global structure of the graph defined by the pairwise similarities has been proposed. However, the existing graph regularized ranking methods are very sensitive to the choice of the graph model and parameters, and this remains a difficult problem for most of the protein domain ranking methods. Results To tackle this problem, we have developed the Multiple Graph regularized Ranking algorithm, MultiG-Rank. Instead of using a single graph to regularize the ranking scores, MultiG-Rank approximates the intrinsic manifold of protein domain distribution by combining multiple initial graphs for the regularization. Graph weights are learned with ranking scores jointly and automatically, by alternately minimizing an objective function in an iterative algorithm. Experimental results on a subset of the ASTRAL SCOP protein domain database demonstrate that MultiG-Rank achieves a better ranking performance than single graph regularized ranking methods and pairwise similarity based ranking methods. Conclusion The problem of graph model and parameter selection in graph regularized protein domain ranking can be solved effectively by combining multiple graphs. This aspect of generalization introduces a new frontier in applying multiple graphs to solving protein domain ranking applications.

  17. Multiple graph regularized protein domain ranking

    KAUST Repository

    Wang, Jim Jing-Yan

    2012-11-19

    Background: Protein domain ranking is a fundamental task in structural biology. Most protein domain ranking methods rely on the pairwise comparison of protein domains while neglecting the global manifold structure of the protein domain database. Recently, graph regularized ranking that exploits the global structure of the graph defined by the pairwise similarities has been proposed. However, the existing graph regularized ranking methods are very sensitive to the choice of the graph model and parameters, and this remains a difficult problem for most of the protein domain ranking methods.Results: To tackle this problem, we have developed the Multiple Graph regularized Ranking algorithm, MultiG-Rank. Instead of using a single graph to regularize the ranking scores, MultiG-Rank approximates the intrinsic manifold of protein domain distribution by combining multiple initial graphs for the regularization. Graph weights are learned with ranking scores jointly and automatically, by alternately minimizing an objective function in an iterative algorithm. Experimental results on a subset of the ASTRAL SCOP protein domain database demonstrate that MultiG-Rank achieves a better ranking performance than single graph regularized ranking methods and pairwise similarity based ranking methods.Conclusion: The problem of graph model and parameter selection in graph regularized protein domain ranking can be solved effectively by combining multiple graphs. This aspect of generalization introduces a new frontier in applying multiple graphs to solving protein domain ranking applications. 2012 Wang et al; licensee BioMed Central Ltd.

  18. Trade name and trademark versus domain

    Directory of Open Access Journals (Sweden)

    Jarmila Pokorná

    2013-01-01

    Full Text Available Internet domains have become an integral part of our lives, so one can easily understand that during their use, conflicts can arise, whose participants will search for rules enabling resolution of conflicts. Since the domain name is a replacement of the computer IP address, in the technical sense of the word, this does not concern for domain names a commercial name or brand, because it primarily does not belong to a person in the legal sense of the word and does not serve for its individualization. The average user regularly affiliates domain names with a person offering goods or services on the relevant Website. Domain names used by entrepreneurs in their business activity are often chosen so that the second-level domain (SLD would use words that form the trade name of corporations formed of trading companies. This fact brings domain names close to such designations that serve the individualization of persons or products, especially the trademarks and the commercial name. Domains can come into conflict with the rights to designations, especially trademarks and commercial names. Court practice is resolving these conflicts using rules for unfair competition, or rules for protection of commercial names and trademarks, but it is not ruled out that in the future, special legal regulation of domain names could be established.

  19. Maritime Domain Awareness Architecture Management Hub Strategy

    National Research Council Canada - National Science Library

    2008-01-01

    This document provides an initial high level strategy for carrying out the responsibilities of the national Maritime Domain Awareness Architecture Management Hub to deliver a standards based service...

  20. Transform domain steganography with blind source separation

    Science.gov (United States)

    Jouny, Ismail

    2015-05-01

    This paper applies blind source separation or independent component analysis for images that may contain mixtures of text, audio, or other images for steganography purposes. The paper focuses on separating mixtures in the transform domain such as Fourier domain or the Wavelet domain. The study addresses the effectiveness of steganography when using linear mixtures of multimedia components and the ability of standard blind sources separation techniques to discern hidden multimedia messages. Mixing in the space, frequency, and wavelet (scale) domains is compared. Effectiveness is measured using mean square error rate between original and recovered images.

  1. Extending Brain-Training to the Affective Domain: Increasing Cognitive and Affective Executive Control through Emotional Working Memory Training

    Science.gov (United States)

    Schweizer, Susanne; Hampshire, Adam; Dalgleish, Tim

    2011-01-01

    So-called ‘brain-training’ programs are a huge commercial success. However, empirical evidence regarding their effectiveness and generalizability remains equivocal. This study investigated whether brain-training (working memory [WM] training) improves cognitive functions beyond the training task (transfer effects), especially regarding the control of emotional material since it constitutes much of the information we process daily. Forty-five participants received WM training using either emotional or neutral material, or an undemanding control task. WM training, regardless of training material, led to transfer gains on another WM task and in fluid intelligence. However, only brain-training with emotional material yielded transferable gains to improved control over affective information on an emotional Stroop task. The data support the reality of transferable benefits of demanding WM training and suggest that transferable gains across to affective contexts require training with material congruent to those contexts. These findings constitute preliminary evidence that intensive cognitively demanding brain-training can improve not only our abstract problem-solving capacity, but also ameliorate cognitive control processes (e.g. decision-making) in our daily emotive environments. PMID:21949712

  2. The Extend of Adaptation Bloom's Taxonomy of Cognitive Domain In English Questions Included in General Secondary Exams

    Directory of Open Access Journals (Sweden)

    Mohammad Akram Alzu'bi

    2014-04-01

    Full Text Available The study aimed at analyzing English questions of the Jordanian Secondary Certificate Examinations via Blooms' cognitive levels. An analysis sheet was prepared by the researcher for the purpose of the study, which was ensured to be valid and reliable. The whole questions of the general secondary examinations for English course in both levels (level three and level four during 2010-2013 composed the sample of the study. Frequencies and percentages were tabulated to facilitate the analysis of the results. The result of the study revealed that the total percentage of the first three levels (comprehension, knowledge, and analysis is (69.6 but the total percentage of the last three levels (application, synthesis, and evaluation is (30.4 so it indicated that the English questions included in general secondary examinations emphasize low order thinking levels. The researcher recommended that the questions designers should improve their questioning techniques in writing questions of exams.

  3. LysM domains mediate lipochitin-oligosaccharide recognition and Nfr genes extend the symbiotic host range

    DEFF Research Database (Denmark)

    Radutoiu, Simona; Madsen, Lene H; Madsen, Esben B

    2007-01-01

    Legume-Rhizobium symbiosis is an example of selective cell recognition controlled by host/non-host determinants. Individual bacterial strains have a distinct host range enabling nodulation of a limited set of legume species and vice versa. We show here that expression of Lotus japonicus Nfr1...

  4. Editorial – Wisdom of the Crowds: Extending the Domain of Medical Information to Case Banks and Online Forums

    Directory of Open Access Journals (Sweden)

    Ashok Shyam

    2013-04-01

    Full Text Available As Evident in earlier Editorials [1,2,3], we at JOCR are striving for a bette understanding at Clinical Decision Making and better A Patient Care. Human deliberations and Single observations have been highlighted as important concepts in building a comprehensive paradigm for individual patient management [2,3]. A re-view of the quality and direction of current body of ‘Selective’ literature, which is highly biased towards Evidence Based Medicine (EBM, is needed. EBM has its own role and important place in literature but it might be suffering from a ‘Central Control’ phenomenon in terms of few ‘Chosen’ groups of experts dig the Evidence and instruct others on how to interpret and utilize ‘Evidence’. Here I will like to introduce a concept from Cybernetics called ‘Variety’ which represents possible alternatives or possible bits of information. The concept of variety is embodied by Ashby’s Law which is stated (and also applicable in many forms. The most useful form for us is as stated by Steve Hickey and Hillary Roberts: “Ashby’s Law stipulates that the minimum amount of information needed to give an accurate answer is exactly the amount needed to specify the problem” [4]. This is interpreted as; if the question has lot of variety the answer too will have same amount of variety. A complicated question will not have a simple answer. Management of a complex fracture in patient with multiple co-morbidites in a resourcefully challenged situation cannot be resolved by ‘Cookbook’ approach that EBM will like us to believe. Thus if we need an answer to a complex situation, more information will be needed and on a large scale ‘Wisdom of Crowds’ will be more effective than a controlled guideline. Every one of us holds a part of knowledge about management of these cases and when put together will be much more helpful than the group statistics of large clinical trials. Again as surgeons we need to predict the individual patient outcome and not what will be the outcome in group of such patients. Here if we have had a patient with similar profile, we can model the current patient according to him and apply it to subsequent similar group of patients. However can we get enough information from group statistics to treat Individual patients? This reverse is not found to be true [5] and thus all our Literature which is based on group studies has to be carefully reviewed and interpreted. Again the Best Evidence as defined by a ‘central control’ will go against the Ashby’s law as a group of experts will surely have less variety than an entire profession and their patients. Representation of this individual variety in Patient presentation and management is currently lacking in Literature and the main reason is the group statistical process of approximation and ’rounding off ‘ at all levels of information, practiced in current evidence based literature

  5. Reductive evolution and the loss of PDC/PAS domains from the genus Staphylococcus.

    Science.gov (United States)

    Shah, Neethu; Gaupp, Rosmarie; Moriyama, Hideaki; Eskridge, Kent M; Moriyama, Etsuko N; Somerville, Greg A

    2013-07-31

    number of PDC/PAS-containing proteins within genera. This variation extended to the Staphylococcus genus, which had between 6 and 9 PDC/PAS proteins and some of these appear to be previously undescribed signaling proteins. This latter point is important because most staphylococcal proteins that contain PDC/PAS domains regulate virulence factor synthesis or antibiotic resistance.

  6. A Model of Inter and Multi Disciplinary Domains, and their Mutual Interactions

    Directory of Open Access Journals (Sweden)

    Ophir Dan

    2014-02-01

    Full Text Available The Melvil Dewey Decimal Classification system maps the human knowledge domains into a library classification decimal system, which means that the knowledge is discretized. The domains are countable similarly to how Cantor proved the countability of the fractions' domain. The debate about the "inter-" and "multi-" disciplinary domains may also be extended into "sub-domains" or from another point of view – into "super-domains". However, Science and Technology has rapidly developed after it was classified. If at the beginning, two decimal digits were enough to classify the world's knowledge into a knowledge domain, today we need more digits – about five. This means we are able to display about a million domains of knowledge. The decimal point indicates the sub-division in the zooming-in; the number of such decimal points is unlimited. Thus, the number of hierarchical levels in the knowledge-tree is unlimited. The maximal level is unreachable since it propagates in time. This intriguing issue raises doubts whether the tree is the most appropriate structure in the current state of the knowledge classification. However, I believe that the knowledge tree is a convenient way of expressing various connections between the knowledge domains. There are other models such as multi-level graph-networks that approximate closer to reality. These models can be further visualized by graph diagrams. The knowledge diagram is more complicated, considering the interaction between science and industry relative to each domain. The model of reality might be compared to the object-oriented programming languages approximating reality in order to construct more naturally computer programs that can model the world. The mutual correspondence of the knowledge domains is dynamic. Some examples of relatively new domains are as follows: biotechnology, bioinformatics, nanotechnology, integro-differential equations, data warehouse, data mining, requirements engineering, micro

  7. The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins

    Directory of Open Access Journals (Sweden)

    Perry Jason

    2006-01-01

    Full Text Available Abstract Background An underlying tenet of the epigenetic code hypothesis is the existence of protein domains that can recognize various chromatin structures. To date, two major candidates have emerged: (i the bromodomain, which can recognize certain acetylation marks and (ii the chromodomain, which can recognize certain methylation marks. Results The Epc-N (Enhancer of Polycomb-N-terminus domain is formally defined herein. This domain is conserved across eukaryotes and is predicted to form a right-handed orthogonal four-helix bundle with extended strands at both termini. The types of amino acid residues that define the Epc-N domain suggest a role in mediating protein-protein interactions, possibly specifically in the context of chromatin binding, and the types of proteins in which it is found (known components of histone acetyltransferase complexes strongly suggest a role in epigenetic structure formation and/or recognition. There appear to be two major Epc-N protein families that can be divided into four unique protein subfamilies. Two of these subfamilies (I and II may be related to one another in that subfamily I can be viewed as a plant-specific expansion of subfamily II. The other two subfamilies (III and IV appear to be related to one another by duplication events in a primordial fungal-metazoan-mycetozoan ancestor. Subfamilies III and IV are further defined by the presence of an evolutionarily conserved five-center-zinc-binding motif in the loop connecting the second and third helices of the four-helix bundle. This motif appears to consist of a PHD followed by a mononuclear Zn knuckle, followed by a PHD-like derivative, and will thus be referred to as the PZPM. All non-Epc-N proteins studied thus far that contain the PZPM have been implicated in histone methylation and/or gene silencing. In addition, an unusual phyletic distribution of Epc-N-containing proteins is observed. Conclusion The data suggest that the Epc-N domain is a protein

  8. Intramuscular extended-release naltrexone: current evidence.

    Science.gov (United States)

    Gastfriend, David R

    2011-01-01

    Extended-release naltrexone (XR-NTX; Vivitrol), developed to address poor adherence in addictive disorders, is approved for use in alcohol and opioid-dependence disorders. In alcohol-dependent adults with ≥ 4-day initial abstinence, XR-NTX increased initial and 6-month abstinence. An fMRI study found that XR-NTX attenuated the salience of alcohol visual and olfactory cues in the absence of alcohol, and post hoc analyses demonstrated efficacy even during high cue-exposure holiday periods. Safety and tolerability have generally been good, without adverse hepatic impact or intractable acute pain management. XR-NTX use appears feasible in primary care and public systems, and retrospective claims analyses have found cost savings and decreased intensive service utilization relative to oral agents. In opioid dependence, following detoxification, XR-NTX shows efficacy for maintaining abstinence, improving retention, decreasing craving, and preventing relapse. Trials are also exploring its use for the treatment of stimulant dependence. XR-NTX appears compatible with counseling and self-help attendance. While more research is needed, current findings suggest that a formulation of naltrexone that was sought beginning over three decades ago is fulfilling its promise as an extended-release pharmacotherapeutic. © 2011 New York Academy of Sciences.

  9. Extending Teach and Repeat to Pivoting Wheelchairs

    Directory of Open Access Journals (Sweden)

    Guillermo Del Castillo

    2003-02-01

    Full Text Available The paper extends the teach-and-repeat paradigm that has been successful for the control of holonomic robots to nonholonomic wheelchairs which may undergo pivoting action over the course of their taught movement. Due to the nonholonomic nature of the vehicle kinematics, estimation is required -- in the example given herein, based upon video detection of wall-mounted cues -- both in the teaching and the tracking events. In order to accommodate motion that approaches pivoting action as well as motion that approaches straight-line action, the estimation equations of the Extended Kalman Filter and the control equations are formulated using two different definitions of a nontemporal independent variable. The paper motivates the need for pivoting action in real-life settings by reporting extensively on the abilities and limitations of estimation-based teach-and-repeat action where pivoting and near-pivoting action is disallowed. Following formulation of the equations in the near-pivot mode, the paper reports upon experiments where taught trajectories which entail a seamless mix of near-straight and near-pivot action are tracked.

  10. Extending the viability of sea urchin gametes.

    Science.gov (United States)

    Spiegler, M A; Oppenheimer, S B

    1995-04-01

    The sea urchin is the material of choice for studying many early developmental events. Methods to extend the viability of sea urchin gametes have not received much attention, but it is well known that the eggs are easily damaged by freezing. This study was designed to extend the viability of Lytechinus pictus eggs and sperm without freezing. Gamete viability measurements were based on relative numbers of fertilized vs unfertilized eggs, percentage fertilization, and on observations of embryonic development. Results indicate that gametes can be stored longer and at lower temperatures than previously described. Sperm were consistently kept viable for at least 12 days with little decrease in viability when stored in glass test tubes or plastic petri dishes and submerged in ice inside a refrigerator at 0 +/- 1 degree C. In one experiment, sperm stored in glass test tubes on ice remained viable up to 20 days after extraction. Eggs were maintained from 1 to 7 days, rather than the 1 day or so previously reported, when stored in glass test tubes submerged in ice in a refrigerator at 0 +/- 1 degree C. Results of egg and sperm experiments varied at different times in the season. Such variations may be caused by seasonal cytoplasmic changes, population differences, or the time mature individuals were maintained unfed in aquaria prior to use. Results from this study should be useful for a variety of research, mariculture, and teaching applications in which sea urchin supplies are limited or when the same gamete population is required for subsequent experiments.

  11. Extended kinetic theory applied to snow avalanches

    Science.gov (United States)

    Rauter, Matthias; Fischer, Jan-Thomas; Fellin, Wolfgang; Kofler, Andreas

    2016-04-01

    In this work we apply the extended kinetic theory, a three-dimensional rheological model for rapid granular flows, to the two-dimensional, depth-averaged shallow water framework, used in snow avalanche simulations. Usually, empirical relations are used to determine the basal friction, which represents the material behavior in the avalanche. Here we present an energy equivalent basal friction relation which accounts for energy dissipating processes in the avalanche body as predicted by the extended kinetic theory. The obtained relation is compared to traditional basal friction relations, e.g. the Voellmy model by conducting numerical simulations with both approaches. As reference, field measurements of runout, affected area and velocity are compared to the simulation results. Two avalanche events, that occurred at the Vallée de la Sionne and Ryggfonn test sites, are evaluated with this method. It is shown that the kinetic theory delivers a physically based explanation for the structure of phenomenological friction relations. However, the new form of the frictional terms explicitly takes the flow depth into account. As consequence, improvements in finding unified parameter sets for various observation variables and events of different sizes could be achieved.

  12. An extended synthesis for evolutionary biology.

    Science.gov (United States)

    Pigliucci, Massimo

    2009-06-01

    Evolutionary theory is undergoing an intense period of discussion and reevaluation. This, contrary to the misleading claims of creationists and other pseudoscientists, is no harbinger of a crisis but rather the opposite: the field is expanding dramatically in terms of both empirical discoveries and new ideas. In this essay I briefly trace the conceptual history of evolutionary theory from Darwinism to neo-Darwinism, and from the Modern Synthesis to what I refer to as the Extended Synthesis, a more inclusive conceptual framework containing among others evo-devo, an expanded theory of heredity, elements of complexity theory, ideas about evolvability, and a reevaluation of levels of selection. I argue that evolutionary biology has never seen a paradigm shift, in the philosophical sense of the term, except when it moved from natural theology to empirical science in the middle of the 19th century. The Extended Synthesis, accordingly, is an expansion of the Modern Synthesis of the 1930s and 1940s, and one that--like its predecessor--will probably take decades to complete.

  13. Continuum balances from extended Hamiltonian dynamics.

    Science.gov (United States)

    Giusteri, Giulio G; Podio-Guidugli, Paolo; Fried, Eliot

    2017-06-14

    The classical procedure devised by Irving and Kirkwood in 1950 and completed slightly later by Noll produces counterparts of the basic balance laws of standard continuum mechanics starting from an ordinary Hamiltonian description of the dynamics of a system of material points. Post-1980 molecular dynamics simulations of the time evolution of such systems use extended Hamiltonians such as those introduced by Andersen, Nosé, and Parrinello and Rahman. The additional terms present in these extensions affect the statistical properties of the system so as to capture certain target phenomenologies that would otherwise be beyond reach. We here propose a physically consistent application of the Irving-Kirkwood-Noll procedure to the extended Hamiltonian systems of material points. Our procedure produces balance equations at the continuum level featuring non-standard terms because the presence of auxiliary degrees of freedom gives rise to additional fluxes and sources that influence the thermodynamic and transport properties of the continuum model. Being aware of the additional contributions may prove crucial when designing multiscale computational schemes in which information is exchanged between the atomistic and continuum levels.

  14. Applying SPAM to the extended MWA

    Science.gov (United States)

    Hurley-Walker, N.; Intema, H.

    2017-01-01

    The extended baselines of the MWA move the instrument into a more difficult calibration and imaging regime, where the more widely-separated antennas are more likely to view the sky through different ionospheric conditions, leading to differential refractive effects over the array. Current extrapolations by Trott, Jordan, and Hurley-Walker imply that the diffractive scale will remain larger than the longest baseline for 50-70% of observations, but these are extrapolations only. Other instruments have performed observations with baselines longer than the diffractive scale, and used software techniques to mitigate the ionospheric distortions. One such survey is the Tata Institute of Fundamental Research Giant Metrewave Radio Telescope Sky Survey (TGSS) at 150 MHz. Intema et al. (2016) used the Source Peeling & Atmospheric Modeling (SPAM) software to produce a catalogue of over 600,000 sources from data that had previously been slow and difficult to process. This proposal is for a short series of observations to test the usage of the SPAM software on the extended MWA, and to find the optimal observing parameters for its use. If successful, this could assist other groups in effectively utilising the long baselines.

  15. EXTENDED LUCAS TUBE: GRAF HAMILTONIAN BARU

    Directory of Open Access Journals (Sweden)

    Ernastuti .

    2012-06-01

    Full Text Available A Hamiltonian cycle in a connected graph G is defined as a closed walk that traverses every vertex of G exactly once, except the starting vertex at which the walk also terminates. If an edge from a Hamiltonian cycle is removed, it forms a path calleda Hamiltonian path. A graph G is called Hamiltonian if there is a Hamiltonian cyclein G. It is known that every hypercube graph is Hamiltonian. But when one or more vertices are removed from a hypercube graph, will it still be Hamiltonian? Some induced subgraphs of a hypercube graph such as the Fibonacci cube (FC, the extended Fibonaccicube (EFC, and the Lucas cube (LC have been introduced and their Hamiltonicities have been investigated. Research results showed that less than a third of FC graphs are Hamiltonian although all of them have Hamiltonian path. All EFC graphs are Hamiltonian and none of LC graphs is Hamiltonian although some still have Hamiltonian paths.This paper introduces another subgraph of a hypercube graph called the Extended Lucas Cube (ELC. The ELC is shown to be Hamiltonian by using the approach of k-Gray Code and Bipartition Property.

  16. A Novel Biped Pattern Generator Based on Extended ZMP and Extended Cart-Table Model

    Directory of Open Access Journals (Sweden)

    Guangbin Sun

    2015-07-01

    Full Text Available This paper focuses on planning patterns for biped walking on complex terrains. Two problems are solved: ZMP (zero moment point cannot be used on uneven terrain, and the conventional cart-table model does not allow vertical CM (centre of mass motion. For the ZMP definition problem, we propose the extended ZMP (EZMP concept as an extension of ZMP to uneven terrains. It can be used to judge dynamic balance on universal terrains. We achieve a deeper insight into the connection and difference between ZMP and EZMP by adding different constraints. For the model problem, we extend the cart-table model by using a dynamic constraint instead of constant height constraint, which results in a mathematically symmetric set of three equations. In this way, the vertical motion is enabled and the resultant equations are still linear. Based on the extended ZMP concept and extended cart-table model, a biped pattern generator using triple preview controllers is constructed and implemented simultaneously to three dimensions. Using the proposed pattern generator, the Atlas robot is simulated. The simulation results show the robot can walk stably on rather complex terrains by accurately tracking extended ZMP.

  17. Public domain optical character recognition

    Science.gov (United States)

    Garris, Michael D.; Blue, James L.; Candela, Gerald T.; Dimmick, Darrin L.; Geist, Jon C.; Grother, Patrick J.; Janet, Stanley A.; Wilson, Charles L.

    1995-03-01

    A public domain document processing system has been developed by the National Institute of Standards and Technology (NIST). The system is a standard reference form-based handprint recognition system for evaluating optical character recognition (OCR), and it is intended to provide a baseline of performance on an open application. The system's source code, training data, performance assessment tools, and type of forms processed are all publicly available. The system recognizes the handprint entered on handwriting sample forms like the ones distributed with NIST Special Database 1. From these forms, the system reads hand-printed numeric fields, upper and lowercase alphabetic fields, and unconstrained text paragraphs comprised of words from a limited-size dictionary. The modular design of the system makes it useful for component evaluation and comparison, training and testing set validation, and multiple system voting schemes. The system contains a number of significant contributions to OCR technology, including an optimized probabilistic neural network (PNN) classifier that operates a factor of 20 times faster than traditional software implementations of the algorithm. The source code for the recognition system is written in C and is organized into 11 libraries. In all, there are approximately 19,000 lines of code supporting more than 550 subroutines. Source code is provided for form registration, form removal, field isolation, field segmentation, character normalization, feature extraction, character classification, and dictionary-based postprocessing. The recognition system has been successfully compiled and tested on a host of UNIX workstations. This paper gives an overview of the recognition system's software architecture, including descriptions of the various system components along with timing and accuracy statistics.

  18. Molecular dynamics study of ferroelectric domain nucleation and domain switching dynamics.

    Science.gov (United States)

    Boddu, Vishal; Endres, Florian; Steinmann, Paul

    2017-04-11

    Ferroelectric materials contain domains of ordered electric dipoles, separated by domain walls, that can undergo polarisation switching under externally applied electric fields. The domain switching dynamics in ferroelectric materials plays an essential role in their application to electronic and electro-optic de- vices. Previous studies suggest that the switching occurs largely through domain wall motion which is explained from the viewpoint of statistical physics on surface growth as the behaviour of a pinned elas- tic interface. We perform molecular dynamics simulations to investigate the domain switching process and quantitatively estimate the switching speed of anti-parallel 180° domains in ferroelectric, tetragonal BaTiO 3 perfect single crystals at room temperature using the core-shell model. We observe an unprece- dented, non-linear increase in the domain switching speed caused by the nucleation of new domains within the switching domain. We determine the strength of the electric field to evoke nucleation of new domains and show that the nucleated domains diffuse into nearby favourable domains when the electric field is removed. Furthermore, we discuss the prominence of domain nucleations during ferroelectric switching.

  19. Active equalisation of the sound field in an extended region of a room

    DEFF Research Database (Denmark)

    Orozco-Santillán, Arturo

    1997-01-01

    studied by means of an idealised frequency domain model. The analysis is based on the calculation of the complex source strengths that minimise the difference between the actual sound pressure and the desired sound pressure in the listening area. Results in relation to the position of the sources......A theoretical study of spatial sound equalisation in an extended region in a room has been carried out. The purpose is to reproduce sound without significant spatial fluctuations and to minimise the spectral colouration at low frequencies in a specified region of the room. The problem is first......, the frequency range, and the size and location of the listening area are presented. However, the frequency-domain approach results in non-causal impulse responses that can be realised only at the expense of a delay. Therefore, this analysis is supplemented with a study of the equalisation carried out...

  20. Multiscale Seismic Inversion in the Data and Image Domains

    KAUST Repository

    Zhang, Sanzong

    2015-12-01

    with both synthetic data and field records reveal both the benefits and limitations of WT. • Generalized Differental Semblance Optimization in the Image Domain (GDSO): We now extend the multiscale physics approach to differential semblance optimization (DSO) in the image domain. That is, we identify the space-lag offset H(x, z, h) in the subsurface-offset domain as an implicit function of velocity. It describes the smoothly varying moveout H(x, z, h) of the migration image m(x, z, h) in the subsurface-offset domain, which is analogous to the smoothly varying traveltime residual ∆τ(x) of a reflection event in a shot gather. The velocity model is found that minimizes the objective function ∑x,z,h H(x, z, h)2m(x, z, h)2, where coherent noise is eliminated everywhere except along the picked curve H(x, z, h). This method is denoted as generalized DSO (GDSO) and mitigates the coherent noise problem with DSO. Numerical examples are presented that empirically demonstrate its effectiveness in providing more accurate velocity models compared to conventional DSO.

  1. Visual Recognition by Learning From Web Data via Weakly Supervised Domain Generalization.

    Science.gov (United States)

    Niu, Li; Li, Wen; Xu, Dong; Cai, Jianfei

    2017-09-01

    In this paper, a weakly supervised domain generalization (WSDG) method is proposed for real-world visual recognition tasks, in which we train classifiers by using Web data (e.g., Web images and Web videos) with noisy labels. In particular, two challenging problems need to be solved when learning robust classifiers, in which the first issue is to cope with the label noise of training Web data from the source domain, while the second issue is to enhance the generalization capability of learned classifiers to an arbitrary target domain. In order to handle the first problem, the training samples within each category are partitioned into clusters, where we use one bag to denote each cluster and instances to denote the samples in each cluster. Then, we identify a proportion of good training samples in each bag and train robust classifiers by using the good training samples, which leads to a multi-instance learning (MIL) problem. In order to handle the second problem, we assume that the training samples possibly form a set of hidden domains, with each hidden domain associated with a distinctive data distribution. Then, for each category and each hidden latent domain, we propose to learn one classifier by extending our MIL formulation, which leads to our WSDG approach. In the testing stage, our approach can obtain better generalization capability by effectively integrating multiple classifiers from different latent domains in each category. Moreover, our WSDG approach is further extended to utilize additional textual descriptions associated with Web data as privileged information (PI), although testing data do not have such PI. Extensive experiments on three benchmark data sets indicate that our newly proposed methods are effective for real-world visual recognition tasks by learning from Web data.

  2. Time Domain Stability Margin Assessment of the NASA Space Launch System GN&C Design for Exploration Mission One

    Science.gov (United States)

    Clements, Keith; Wall, John

    2017-01-01

    The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

  3. Time Domain Stability Margin Assessment of the NS Space Launch System GN&C Design for Exploration Mission One

    Science.gov (United States)

    Clements, Keith; Wall, John

    2017-01-01

    The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

  4. Extended MRI findings of intersection syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Roger P.; Hatem, Stephen F.; Recht, Michael P. [Cleveland Clinic, Cleveland, OH (United States)

    2009-02-15

    The symptoms and physical findings of intersection syndrome have been well described in the clinical medical literature. However, the magnetic resonance imaging (MRI) findings in patients with intersection syndrome of the forearm have only recently been described in a small number of patients. We review our experience with imaging of intersection syndrome, describe previously unreported MRI findings, and emphasize modifications to MRI protocols for its evaluation. Institutional review board approval was obtained for this retrospective review of patients with MRI findings consistent with intersection syndrome of the forearm during the period from January 2004 to September 2006. Six patients were identified, three males and three females, with an average age of 39.3 years. The MRI examinations were reviewed to assess signal abnormalities within and adjacent to the first and second dorsal extensor tendon compartments (DETC): tendinosis, peritendinous edema or fluid, muscle edema, subcutaneous edema, and juxtacortical edema. The overall longitudinal extent of signal alterations was measured as well as the distance from Lister's tubercle to the crossover of the first and second DETC. Review of the MRIs showed increased intrasubstance tendon signal suggesting tendinosis in two of the six patients, peritendinous edema or fluid in all six patients, muscle edema in five of the six patients, and subcutaneous edema in three of the six patients. Juxtacortical edema was seen in one patient. Peritendinous edema or fluid extended distally beyond the radiocarpal joint in three of the six patients. The average distance from Lister's tubercle to the crossover of the first and second DETC was 3.95 cm, in keeping with recently published data. Intersection syndrome is an uncommon MRI diagnosis. In addition to the previously described MRI findings of edema adjacent to the first or second DETC, possibly with proximal extension and subcutaneous edema, we have identified

  5. Epigenetic Histone Marks of Extended Meta-Polycentric Centromeres of Lathyrus and Pisum Chromosomes

    Science.gov (United States)

    Neumann, Pavel; Schubert, Veit; Fuková, Iva; Manning, Jasper E.; Houben, Andreas; Macas, Jiří

    2016-01-01

    Species of the legume genera Lathyrus and Pisum possess chromosomes that exhibit a unique structure of their centromeric regions, which is clearly apparent during metaphase by the formation of extended primary constrictions which span up to a third of the length of the chromosome. In addition, these species express two different variants of the CenH3 protein which are co-localized in multiple domains along the poleward surface of the primary constrictions. Here, we show that the constrictions represent a distinct type of chromatin differing from the chromosome arms. In metaphase, histone phosphorylation patterns including H3S10ph, H3S28ph, and H3T3ph were observed along the entire constriction, in a way similar to holocentric chromosomes. On the other hand, distribution of phosphorylated H2AT120 was different from that previously reported from either, holocentric and monocentric chromosomes, occurring at chromatin surrounding but not overlapping CenH3 domains. Since some of these phosphorylations play a role in chromatid cohesion, it can be assumed that they facilitate correct chromosome segregation by ensuring that multiple separate CenH3 domains present on the same chromatid are oriented toward the same pole. The constrictions also displayed distinct patterns of histone methylation marks, being enriched in H3K9me2 and depleted in H3K4me3 and H3K27me2 compared to the chromosome arms. Super-resolution fluorescence microscopy revealed that although both CenH3 protein variants are present in all CenH3 domains detected on metaphase chromosomes, they are only partially co-localized while there are chromatin subdomains which are mostly made of only one CenH3 variant. Taken together, these data revealed specific features of extended primary constrictions of Lathyrus and Pisum and support the idea that they may represent an intermediate stage between monocentric and holocentric chromosomes. PMID:26973677

  6. Genomewide analysis of LATERAL ORGAN BOUNDARIES Domain ...

    Indian Academy of Sciences (India)

    The investigation of transcription factor (TF) families is a major focus of postgenomic research. The plant-specific ASYMMETRIC LEAVES2-LIKE (ASL) / LATERAL ORGAN BOUNDARIES Domain (LBD) proteins constitute a major zincfinger-like-domain transcription factor family, and regulate diverse biological processes in ...

  7. Domain decomposition methods for hyperbolic problems

    Indian Academy of Sciences (India)

    problems using domain decomposition but this technique faces difficulties if the system becomes characteristic at the inter-element boundaries. By making the inter-element boundaries move faster than the fastest wave speed associated with the hyperbolic system we are able to overcome this problem. Keywords. Domain ...

  8. Enhanced functional and structural domain assignments using ...

    Indian Academy of Sciences (India)

    Unknown

    biology of MTB, yet the functions of many MTB proteins are unknown. We have used sensitive profile-based search procedures to assign functional and structural domains to infer functions of gene products encoded in. MTB. These domain assignments have been made using a compendium of sequence and structural ...

  9. Time domain NMR applied to food products

    NARCIS (Netherlands)

    Duynhoven, van J.P.M.; Voda, A.; Witek, M.M.; As, van H.

    2010-01-01

    Time-domain NMR is being used throughout all areas of food science and technology. A wide range of one- and two-dimensional relaxometric and diffusometric applications have been implemented on cost-effective, robust and easy-to-use benchtop NMR equipment. Time-domain NMR applications do not only

  10. Domain Wall Propagation through Spin Wave Emission

    NARCIS (Netherlands)

    Wang, X.S.; Yan, P.; Shen, Y.H.; Bauer, G.E.W.; Wang, X.R.

    2012-01-01

    We theoretically study field-induced domain wall motion in an electrically insulating ferromagnet with hard- and easy-axis anisotropies. Domain walls can propagate along a dissipationless wire through spin wave emission locked into the known soliton velocity at low fields. In the presence of

  11. Strong diamagnetism for general domains and applications

    DEFF Research Database (Denmark)

    Fournais, Søren; Helffer, Bernard

    2007-01-01

    We consider the Neumann Laplacian with constant magnetic field on a regular domain. Let $B$ be the strength of the magnetic field, and let $\\lambda_1(B)$ be the first eigenvalue of the magnetic Neumann Laplacian on the domain. It is proved that $B \\mapsto \\lambda_1(B)$ is monotone increasing for ...

  12. Thermodynamic magnon recoil for domain wall motion

    NARCIS (Netherlands)

    Yan, P.; Cao, Y.; Sinova, J.

    2015-01-01

    We predict a thermodynamic magnon recoil effect for domain wall motions in the presence of temperature gradients. All current thermodynamic theories assert that a magnetic domain wall must move toward the hotter side, based on equilibrium thermodynamic arguments. Microscopic calculations, on the

  13. UBA domain containing proteins in fission yeast

    DEFF Research Database (Denmark)

    Hartmann-Petersen, Rasmus; Semple, Colin A M; Ponting, Chris P

    2003-01-01

    characterised on both the functional and structural levels. One example of a widespread ubiquitin binding module is the ubiquitin associated (UBA) domain. Here, we discuss the approximately 15 UBA domain containing proteins encoded in the relatively small genome of the fission yeast Schizosaccharomyces pombe...

  14. Domain 2: Sport Safety and Injury Prevention

    Science.gov (United States)

    Gurchiek, Larry; Mokha, Monique Butcher

    2004-01-01

    Most coaches recognize the importance of creating a safe environment and preventing injuries of their athletes. Domain 2 is dedicated to this important aspect of coaching, and outlines specific areas within safety and injury prevention that coaches should address. Domain 2 sets the standards for facility, equipment, and environmental safety…

  15. Superfast domain walls in KTP single crystals

    Science.gov (United States)

    Shur, V. Ya.; Esin, A. A.; Alam, M. A.; Akhmatkhanov, A. R.

    2017-10-01

    Potassium titanyl phosphate KTiOPO4 (KTP) crystals with periodical ferroelectric domain structures are one of the most promising materials for nonlinear optics, in which the main types of nonlinear optical interactions have been demonstrated. Despite the crucial importance of the in situ visualization of domain structure kinetics for creation of high quality periodical domain gratings, there are only a few works concerning KTP. We present the results of in situ visualization of domain kinetics in KTP with the time resolution down to 12.5 μs and simultaneous recording of the switching current data. The wide range of wall velocities with two orders of magnitude difference was observed for switching in a uniform electric field. The kinetic maps allowed analyzing the spatial distribution of wall motion velocities and classifying the walls by velocity ranges. The distinguished slow, fast, and superfast types of domain walls differed by their orientation. It was shown that the fast and slow domain walls provided the smooth input to the switching current, whereas the short-lived superfast walls resulted in short current peaks. The mobility and the threshold fields for all types of domain walls were estimated. The revealed increase in the wall velocity with deviation from low-index crystallographic planes for slow and fast walls was considered in terms of determined step generation and anisotropic kink motion. The obtained results are important for further development of domain engineering in KTP required for creation of high power, reliable, and effective coherent light sources.

  16. Chiral gauge theories with domain wall fermions

    OpenAIRE

    Golterman, M.; Jansen, K.; Petcher, D.; Vink, J.

    1993-01-01

    We have investigated a proposal to construct chiral gauge theories on the lattice using domain wall fermions. The model contains two opposite chirality zeromodes, which live on two domain walls. We couple only one of them to a gauge field, but find that mirror fermions which also couple to the gauge field always seem to exist.

  17. Is the myonuclear domain size fixed?

    NARCIS (Netherlands)

    van der Meer, S.F.T.; Jaspers, R. T.; Degens, H.

    2011-01-01

    It has been suggested that the number of myonuclei in a muscle fibre changes in proportion to the change in fibre size, resulting in a constant myonuclear domain size, defined as the cytoplasmic volume per myonucleus. The myonuclear domain size varies, however, between fibre types and is inversely

  18. Frequency Domain Image Filtering Using CUDA

    Directory of Open Access Journals (Sweden)

    Muhammad Awais Rajput

    2014-10-01

    Full Text Available In this paper, we investigate the implementation of image filtering in frequency domain using NVIDIA?s CUDA (Compute Unified Device Architecture. In contrast to signal and image filtering in spatial domain which uses convolution operations and hence is more compute-intensive for filters having larger spatial extent, the frequency domain filtering uses FFT (Fast Fourier Transform which is much faster and significantly reduces the computational complexity of the filtering. We implement the frequency domain filtering on CPU and GPU respectively and analyze the speed-up obtained from the CUDA?s parallel processing paradigm. In order to demonstrate the efficiency of frequency domain filtering on CUDA, we implement three frequency domain filters, i.e., Butterworth, low-pass and Gaussian for processing different sizes of images on CPU and GPU respectively and perform the GPU vs. CPU benchmarks. The results presented in this paper show that the frequency domain filtering with CUDA achieves significant speed-up over the CPU processing in frequency domain with the same level of (output image quality on both the processing architectures

  19. implementation of spatial domain homomorphic filtering

    African Journals Online (AJOL)

    eobe

    Keywords: Spatial domain homomorphic filtering, contrast enhancement, image processing, java programming. 1. INTRODUCTION. There is a lot of background literature on frequency- domain Homomorphic filtering [1-2]. However, such a scheme is too costly and complex to implement in digital and embedded hardware ...

  20. SEM/EBIC investigations of extended defect system in GaN epilayers

    Energy Technology Data Exchange (ETDEWEB)

    Shmidt, N.M.; Sitnikova, A.A.; Zolotareva, R.V. [Ioffe Physico-Technical Institute, RAS, St. Petersburg (Russian Federation); Sirotkin, V.V.; Soltanovich, O.A.; Yakimov, E.B. [Institute of Microelectronics Technology, RAS, Chernogolovka (Russian Federation)

    2005-04-01

    The EBIC investigations of extended defect system in GaN epitaxial layers with different electron mobility and dislocation density have been carried out. The recombination strength and defect cylinder radius for threading dislocations have been estimated from their EBIC profiles. Some cellular structure is revealed in the samples with the less-ordered mosaic structure that could be associated with the enhanced recombination activity of domain boundaries in such layers. (copyright 2005 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)