Topical Treatment of Degenerative Knee Osteoarthritis.

Science.gov (United States)

Meng, Zengdong; Huang, Rongzhong

2018-01-01

This article reviews topical management strategies for degenerative osteoarthritis (OA) of the knee. A search of Pubmed, Embase and the Cochrane library using MeSH terms including "topical," "treatment," "knee" and "osteoarthritis" was carried out. Original research and review articles on the effectiveness and safety, recommendations from international published guidelines and acceptability studies of topical preparations were included. Current topical treatments included for the management of knee OA include topical nonsteroidal anti-inflammatory drugs, capsaicin, salicylates and physical treatments such as hot or cold therapy. Current treatment guidelines recommend topical nonsteroidal anti-inflammatory drugs as an alternative and even first-line therapy for OA management, especially among elderly patients. Guidelines on other topical treatments vary, from recommendations against their use, to in favor as alternative or simultaneous therapy, especially for patients with contraindications to other analgesics. Although often well-tolerated and preferred by many patients, clinical care still lags in the adoption of topical treatments. Aspects of efficacy, safety and patient quality of life data require further research. Copyright © 2018 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

Proceedings of fifth international topical meeting on nuclear thermal hydraulics, operations and safety

International Nuclear Information System (INIS)

1997-01-01

The fifth international topical meeting on nuclear thermohydraulics, operations and safety was convened in Beijing in April 14-18, 1997. The topical meeting was sponsored by the Chinese Nuclear Society and cosponsored by American Nuclear Society, Atomic Energy Society of Japan, American Society of Mechanical Engineers, Canada Nuclear Society, Korean Nuclear Society, Mexican Nuclear Society, Nuclear Society of Slovenia and Spanish Nuclear Society. There were 262 articles were published in the meeting. They are related nuclear power thermohydraulics, operations and safety

Draft statement by the Watt Committee on Safety and related topics as respects nuclear power

Energy Technology Data Exchange (ETDEWEB)

1982-03-01

The following topics are examined, with particular reference to nuclear power: the nature of risk; waste disposal to the environment (ecological damage and radiation damage due to nuclear plants and fossil-fuel plants); the benefits of nuclear power (including discussion of the following matters: need to conserve fossil fuels; safety; and possibility of diversion to nuclear weapons).

Science of safety topic coverage in experiential education in US and Taiwan colleges and schools of pharmacy.

Science.gov (United States)

Tang, Derek H; Warholak, Terri L; Slack, Marion K; Malone, Daniel C; Gau, Churn-Shiouh

2011-12-15

To compare the science of safety (SoS) topic coverage and associated student competencies in the experiential education curricula of colleges and schools of pharmacy in the United States and Taiwan. The experiential education director, assistant director, or coordinator at a random sample of 34 US colleges and schools of pharmacy and all 7 Taiwan schools of pharmacy were interviewed and then asked to complete an Internet-based survey instrument. Faculty members in both countries perceived that experiential curricula were focused on the postmarketing phase of the SoS, and that there is a need for the pharmacy experiential curricula to be standardized in order to fill SoS coverage gaps. Inter-country differences in experiential SoS coverage were noted in topics included for safety biomarkers that signal potential for drug-induced problems and pharmacogenomics. Experiential SoS topic coverage and student ability gaps were perceived within and between US and Taiwan colleges and schools of pharmacy.

Efficacy and safety of topical tranexamic acid in knee arthroplasty.

Science.gov (United States)

López-Hualda, Álvaro; Dauder-Gallego, Cristina; Ferreño-Márquez, David; Martínez-Martín, Javier

2018-02-26

Tranexamic acid (TXA) is commonly used to control postoperative blood loss in total knee arthroplasty. In order to avoid adverse effects associated with intravenous administration, topical use has been proposed as an alternative. Our aim was to evaluate the efficacy and safety of topical TXA in total knee arthroplasty. A total of 90 patients scheduled for unilateral total knee arthroplasty were included in a prospective randomised study. All surgeries were performed under spinal anaesthesia, tourniquet and the same postoperative protocol. Patients were allocated to one of the 3 groups according to the application of TXA: group A (n=30) 1g of topical TXA; group B (n=30) 1g of TXA intravenous and in group C or the control group (n=30) no drug was administrated. Parameters related to blood loss and drain outputs were compared between the 3 groups. The results revealed that post-operative decrease in haemoglobin level was significantly lower in group A (1.95g/dL) than group B (2.25g/dL) and group C (2.96g/dL), P<.01. Total postoperative blood loss was lower in group A (195mL) than group B (466mL) and group C (718mL), P<.01. There was no significant difference in complications and allogenic blood transfusion rate between the 3 groups. According to the results, topical application of 1g TXA significantly reduced blood loss in patients undergoing total knee arthroplasty more than intravenous or no administration of TXA. Copyright © 2018 Elsevier España, S.L.U. All rights reserved.

The Role of the Biosphere in a Safety Case. IGSC topical session at the third IGSC Meeting

International Nuclear Information System (INIS)

Russell, Sean; Voinis, Sylvie; Alonso, Jesus; Van Luik, Abraham E.

2002-01-01

. It also included one presentation on a peer review as a tool to build confidence in a safety case through an improvement of the comprehension on the biosphere and its role in a safety case. 48 participants represented several national waste management organisations and regulatory authorities from 15 OECD member's countries and the IAEA. The Topical Session was split in three parts: - Part one related to the scientific bases on the biosphere; - Part two was concerned with the regulators requirements; and - Part three aimed to present some examples as regards the implementers strategies. The current synthesis presented in Part A is aimed at briefly reflecting the material presented at this Topical Session and providing a short overview of its main outcomes. The written contributions are compiled without further elaboration from the Secretariat, in Part B of the document. Part C gives the list of participants at this Topical Session

AMNT 2014. Key topic: Reactor operation, safety - report. Pt. 3

Energy Technology Data Exchange (ETDEWEB)

Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Sicherheitsforschung (NUKLEAR); Mull, Thomas [AREVA GmbH, Erlangen (Germany). Nuclear Fusion, HTR and Transverse Issues (PTDH-G); Starflinger, Joerg [Stuttgart Univ. (Germany). Inst. fuer Kernenergetik und Energiesysteme (IKE)

2015-01-15

Summary report on the following sessions of the Annual Conference on Nuclear Technology held in Frankfurt, 6 to 8 May 2014: - Reactor Operation, Safety: Radiation Protection (Angelika Bohnstedt); - Competence, Innovation, Regulation: Fusion Technology - Optimisation Steps in the ITER Design (Thomas Mull); - Competence, Innovation, Regulation: Education, Expert Knowledge, Knowledge Transfer (Joerg Starflinger). The other Sessions of the Key Topics 'Reactor Operation, Safety', 'Competence, Innovation, Regulation' and 'Fuel, Decommissioning and Disposal' have been covered in atw 10 and 12 (2015) and will be covered in further issues of atw.

Safety culture in nuclear installations: Summary of an international topical meeting

International Nuclear Information System (INIS)

Carnino, A.; Derrough, M.; Weimann, G.

1996-01-01

An international topical meeting, Safety Culture in Nuclear Installations, was organized by the American Nuclear Society (ANS) Austria Local Section, cosponsored by the ANS Nuclear Reactor Safety and Human Factors Divisions in cooperation with the Nuclear Energy Agency of the Organization for Economic Cooperation and Development (NEA/OECD) and held in Vienna April 24-28, 1995. Some 250 experts from 30 different countries and organizations took part in the 85 paper presentations and two workshops. The concept of safety culture was initially used in the first International Nuclear Safety Advisory Group (INSAG) report on the Chernobyl accident analysis report in 1986. Although some elements of safety culture have been used over the years in nuclear safety activities, the new phrase safety culture and the concept were found interesting as highlighting the 'soft' aspects of safety and as encompassing more than human errors. Unfortunately, for many years it was used more in the way of identifying lack of safety culture. Conscious of this application, INSAG further developed the safety culture concept in the INSAG 4 report: The report contains a definition, the universal aspects of safety culture, the two main components of safety culture management and individual behaviour, and performance indicators of a good safety culture. This report is now quite famous and adopted with some additions or complementary definitions by many institutes and organizations for their daily activities

Five Topics Health Care Simulation Can Address to Improve Patient Safety

DEFF Research Database (Denmark)

Sollid, Stephen J M; Dieckman, Peter; Aase, Karina

2017-01-01

OBJECTIVES: There is little knowledge about which elements of health care simulation are most effective in improving patient safety. When empirical evidence is lacking, a consensus statement can help define priorities in, for example, education and research. A consensus process was therefore...... initiated to define priorities in health care simulation that contribute the most to improve patient safety.  METHODS: An international group of experts took part in a 4-stage consensus process based on a modified nominal group technique. Stages 1 to 3 were based on electronic communication; stage 4 was a 2......-day consensus meeting at the Utstein Abbey in Norway. The goals of stage 4 were to agree on the top 5 topics in health care simulation that contribute the most to patient safety, identify the patient safety problems they relate to, and suggest solutions with implementation strategies...

Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease

OpenAIRE

Elsaadany, Basma Abdelaleem; Ahmed, Eman Magdy; Aghbary, Sana Maher Hasan

2017-01-01

Background. Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence. Objective. This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alter...

International conference on topical issues in nuclear installation safety: Continuous improvement of nuclear safety in a changing world. Book of contributed papers

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

Papers presented at this conference where devoted to the following NPP safety related topical issues: Changing environments - coping with diversity and globalisation; Operating experience - managing changes effectively; Regulatory management systems - adapting to changes in the environment; Long term operations - maintaining safety margins while extending plant lifetime.

Safety of research reactors. Topical issues paper no. 4

International Nuclear Information System (INIS)

Alcala-Ruiz, F.; Ferraz-Bastos, J.L.; Kim, S.C.; Voth, M.; Boeck, H.; Dimeglio, F.; Litai, D.

2001-01-01

Assessment of Research Reactors (INSARR) missions. The prime objective of these missions has been to conduct a comprehensive operational safety review of the research reactor facility and to verify compliance with the IAEA Safety Standards. The methods used during an INSARR mission have been collected and analysed. Some of the important issues identified are the following: general ageing of the facility; uncertain status of many research reactors (in extended shutdown); indefinite deferral of return to operation or decommissioning; inadequate regulatory supervision; insufficient systematic (periodic) reassessment of safety; lack of quality assurance (QA) programmes; lack of an international safety convention or arrangement; lack of financial support for safety measures (e.g. safety reassessment, safety upgrading, decommissioning) and utilization; lack of clear utilization programmes; inadequate emergency preparedness; inadequate safety documentation (e.g. safety analysis report, operating rules and procedures, emergency plan); inadequate funding of shutdown reactors; weak safety culture; loss of expertise and corporate memory; loss of information concerning radioactive materials contained in retired experimental devices stored in the facility indefinitely; obsolescence of equipment and lack of spare parts; inadequate training and qualifications of regulators and operators; safety implications of new fuel types. These issues have been addressed by the IAEA Secretariat and the chairman of the International Nuclear Safety Advisory Group (INSAG). INSAG has identified three major safety issues that are: the increasing age of research reactors, the number of research reactors that are not operating anymore but have not been decommissioned, and the number of research reactors in countries that do not have appropriate regulatory authorities. This issue paper discusses the concerns generated by an analysis of the results of INSARR missions and those expressed by INSAG. The

Safety awareness educational topics for the construction of power transmission systems with smart grid technologies

Directory of Open Access Journals (Sweden)

Bryan Hubbard

2013-09-01

Full Text Available Power transmission facilities in the U.S. are undergoing a transformation due to the increased use of distributed generation sources such as wind and solar power.  The current power grid system is also antiquated and in need of substantial retrofits to make it more efficient and reliable.  The new energy transmission system being designed and built to optimize power delivery is known as “Smart Grid”.  The increased activity in the construction of power transmission facilities and installation of new technologies into the current power system raises potential safety concerns.  Existing construction management curriculum may include general information about safety training, but does not typically include information about this specialized sector.  The objective of this study was to work with industry to identify key safety topics appropriate for inclusion in an introductory industrial construction course.  Results of interviews with industry identified numerous hazards that are not typically covered in typical construction curricula.  A joint undergraduate and graduate course in industrial construction was created to address these and additional concepts. A survey of the students was performed to determine the effectiveness of the course and also to determine their thoughts about the smart grid technologies and safety training. Information on electrical system hazards is presented along with results of the student surveys.

Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis.

Science.gov (United States)

Shoughy, Samir S; Jaroudi, Mahmoud O; Tabbara, Khalid F

2016-01-01

The objective of this study was to evaluate the efficacy and safety of topical low-dose tacrolimus (0.01%) solution in patients with vernal keratoconjunctivitis (VKC). A total of 62 consecutive patients with VKC refractory to conventional treatment were included retrospectively. Tacrolimus 0.01% ophthalmic solution was administered to patients twice daily after discontinuation of all previous topical medications. The duration of treatment ranged from 1 month to 29 months. The clinical symptoms of itching, redness, foreign body sensation, and discharge and the clinical signs of conjunctival hyperemia, conjunctival papillary hypertrophy, limbal infiltration, Trantas dots, and superficial punctate keratopathy were graded as 0 (normal), 1+ (mild), 2+ (moderate), or 3+ (severe). Assessment was carried out before initiation of therapy and on the last visit after treatment. There were 62 patients with VKC comprising 49 male and 13 female patients. The median age was 12 years (range: 5-47 years). The mean visual acuity improved from 20/30 to 20/25 following treatment. There was statistically significant improvement in symptoms of itching (P<0.001), redness (P<0.001), foreign body sensation (P<0.001), and discharge (P<0.001). Statistically significant improvement was also observed in clinical signs of conjunctival hyperemia (P<0.001), limbal infiltration (P<0.001), Trantas dots (P<0.001), superficial punctate keratopathy (P<0.001), and conjunctival papillary hypertrophy (P<0.001). The solution form of tacrolimus was well tolerated. None of the patients developed elevation of intraocular pressure, cataract, or infectious keratitis. Low-dose topical tacrolimus 0.01% solution is effective and safe in the management of patients with refractory VKC.

Efficacy and safety of low-dose topical tacrolimus in vernal keratoconjunctivitis

Directory of Open Access Journals (Sweden)

Shoughy SS

2016-04-01

Full Text Available Samir S Shoughy,1 Mahmoud O Jaroudi,1 Khalid F Tabbara1–3 1The Eye Center and The Eye Foundation for Research in Ophthalmology, 2Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 3Wilmer Ophthalmological Institute of the Johns Hopkins University School of Medicine, Baltimore, MD, USA Objective: The objective of this study was to evaluate the efficacy and safety of topical low-dose tacrolimus (0.01% solution in patients with vernal keratoconjunctivitis (VKC. Patients and methods: A total of 62 consecutive patients with VKC refractory to conventional treatment were included retrospectively. Tacrolimus 0.01% ophthalmic solution was administered to patients twice daily after discontinuation of all previous topical medications. The duration of treatment ranged from 1 month to 29 months. The clinical symptoms of itching, redness, foreign body sensation, and discharge and the clinical signs of conjunctival hyperemia, conjunctival papillary hypertrophy, limbal infiltration, Trantas dots, and superficial punctate keratopathy were graded as 0 (normal, 1+ (mild, 2+ (moderate, or 3+ (severe. Assessment was carried out before initiation of therapy and on the last visit after treatment. Results: There were 62 patients with VKC comprising 49 male and 13 female patients. The median age was 12 years (range: 5–47 years. The mean visual acuity improved from 20/30 to 20/25 following treatment. There was statistically significant improvement in symptoms of itching (P<0.001, redness (P<0.001, foreign body sensation (P<0.001, and discharge (P<0.001. Statistically significant improvement was also observed in clinical signs of conjunctival hyperemia (P<0.001, limbal infiltration (P<0.001, Trantas dots (P<0.001, superficial punctate keratopathy (P<0.001, and conjunctival papillary hypertrophy (P<0.001. The solution form of tacrolimus was well tolerated. None of the patients developed elevation of intraocular pressure

Safety of fuel cycle facilities. Topical issues paper no. 3

International Nuclear Information System (INIS)

Ranguelova, V.; Niehaus, F.; Delattre, D.

2001-01-01

A wide range of nuclear fuel cycle facilities are in operation. These installations process, use, store and dispose of radioactive material and cover: mining and milling, conversion, enrichment, fuel fabrication (including mixed oxide fuel), reactor, interim spent fuel storage, reprocessing, waste treatment and waste disposal facilities. For the purposes of this paper, reactors and waste disposal facilities are not considered. The term 'fuel cycle facilities' covers only the remainder of the installations listed above. The IAEA Secretariat maintains a database of fuel cycle facilities in its Member States. Known as the Nuclear Fuel Cycle Information System (NFCIS), it is available as an on-line service through the Internet. More than 500 such facilities have been reported under this system. The facilities are listed by facility type and operating status. Approximately one third of all of the facilities are located in developing States. About half of all facilities are reported to be operating, of which approximately 40% are operating in developing States. In addition, some 60 facilities are either in the design stage or under construction. Although the radioactive source term for most fuel cycle facilities is lower than the source term for reactors, which results in less severe consequences to the public from potential accidents at these fuel cycle installations, recent events at some fuel cycle facilities have given rise to public concern which has to be addressed adequately by national regulatory bodies and at the international level. Worldwide, operational experience feedback warrants improvements in the safety of these facilities. Some of the hazards are similar for reactor and non-reactor facilities. However, the differences between these installations give rise to specific safety concerns at fuel cycle facilities. In particular, these concerns include: criticality, radiation protection of workers, chemical hazards, fire and explosion hazards. It is recognized

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key topic / Enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Traichel, Anke [NUKEM Technologies Engineering Services GmbH, Alzenau (Germany). Dept. of Safety Engineering and Assessment / Proposals Engineering

2017-04-15

Summary report on the Key Topic ''Enhanced Safety and Operation Excellence'' Technical Session ''Safety, IT, Hazards and PSA'' of the 47th Annual Meeting on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016.

Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast.

Science.gov (United States)

Miller, Jessica A; Thompson, Patricia A; Hakim, Iman A; Lopez, Ana Maria; Thomson, Cynthia A; Chew, Wade; Hsu, Chiu-Hsieh; Chow, H-H Sherry

2012-10-01

Limonene, a major component in citrus oil, has demonstrated anti-cancer effects in preclinical mammary cancer models. However, the effective oral dose translates to a human dose that may not be feasible for chronic dosing. We proposed to evaluate topical application of limonene to the breast as an alternative dosing strategy. We conducted a mouse disposition study to determine whether limonene would be bio available in the mammary tissue after topical application. SKH-1 mice received topical or oral administration of limonene in the form of orange oil every day for 4 weeks. Plasma and mammary pads were collected 4 hrs after the final dosing. We also conducted an exploratory clinical study to evaluate the safety and feasibility of topically applied limonene in the form of orange oil to the breast. Healthy women were recruited to apply orange oil containing massage oil to their breasts daily for four weeks. Safety and feasibility were assessed by reported adverse events, clinical labs, and usage compliance. Pre and post-intervention nipple aspirate fluid (NAF) and plasma were collected for limonene concentration determination. The mouse disposition study showed that topical and oral orange oil administration resulted in similar mammary tissue disposition of limonene with no clinical signs of toxicity. In the clinical study, the topical application of limonene containing massage oil to the breast was found to be safe with high levels of usage compliance for daily application, although NAF and plasma limonene concentrations were not significantly changed after the massage oil application. Our studies showed that limonene is bio available in mammary tissue after topical orange oil application in mice and this novel route of administration to the breast is safe and feasible in healthy women.

International Conference on Topical Issues in Nuclear Installation Safety: Defence in Depth — Advances and Challenges for Nuclear Installation Safety. Proceedings of an International Conference held in Vienna, Austria, 21-24 October 2013

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-10-15

The fifth International Conference on Topical Issues in Nuclear Installation Safety was dedicated to the defence in depth (DID) concept which is fundamental to the safety of nuclear installations. The main focus of the conference was to foster the exchange of information on the implementation of DID and the associated challenges. This CD-ROM contains the papers presented at the conference as well as the summary and conclusions, including recommendations for further actions to strengthen DID and its implementation.

How could the topic patient safety be embedded in the curriculum? A recommendation by the Committee for Patient Safety and Error Management of the GMA.

Science.gov (United States)

Kiesewetter, Jan; Drossard, Sabine; Gaupp, Rainer; Baschnegger, Heiko; Kiesewetter, Isabel; Hoffmann, Susanne

2018-01-01

The topic of patient safety is of fundamental interest for the health care sector. In view of the realisation of the National Competence-Based Learning Objectives Catalogue for Undergraduate Medical Education (NKLM) this topic now has to be prepared for medical education. For a disciplinary and content-related orientation the GMA Committee developed the Learning Objectives Catalogue Patient Safety for Undergraduate Medical Education (GMA-LZK). To ensure an optimal implementation of the GMA-LZK we recommend a longitudinal embedding into the existing curriculum. This position paper supports the implementation of the GMA-LZK and is aimed at everyone who wants to establish teaching courses on the topic patient safety and embed them in the curriculum. In light of this, we will initially describe the key features for a structured analysis of the current situation. Based on three best-practice-examples, as seen in the faculties of Freiburg, Bonn and Munich, different approaches to the implementation of the GMA-LZK will be illustrated. Lastly, we will outline the methodical requirements regarding the curriculum development as well as the disciplinary and methodical competences that the lecturers will have to hold or develop to fulfil the requirements.

Topical session proceedings of the 4. IGSC meeting on: the potential impacts on repository safety from potential partitioning and transmutation programme

International Nuclear Information System (INIS)

Wollrath, Juergen; Voinis, Sylvie; Hadermann, Joerg; Van Luik, Abraham E.

2003-01-01

The bulk of radioactive waste results mainly from energy production in nuclear power plants. At present, this waste is safely stored near reactor sites, in dedicated storage facilities, and low-level wastes in some countries are disposed of in near surface disposal facilities. The stored wastes are accumulating, and the generally agreed-to solution is to dispose of vitrified waste or spent fuel in deep geological disposal facilities. The main concern in the disposal of radioactive waste is related to long-lived radionuclides - some of them will remain hazardous for tens of thousands of years and longer. To demonstrate the safety of geological disposal of radioactive waste a safety case has to be developed for a specific concept of disposal at a given site. This safety case is a collection of arguments at a given stage of repository development in support of the long-term safety of the repository. The safety case comprises the findings of a safety assessment and a statement of confidence in these findings. The type of waste to be disposed of is an important component of the disposal concept. At present, novel fuel cycles are under investigation at national and international levels including research in partitioning and transmutation (P and T) technologies. Comprehensive projects are carried out in OECD countries, notably France, Japan and the USA. Within the Nuclear Fission Safety programme the European Commission (EC) is supporting several projects and it is anticipated that the contribution of the EC will increase within the 6. Framework Programme. In addition the Nuclear Energy Agency has recently published a report comparing fuel cycles for accelerator driven systems and fast reactors. By using P and T it might be possible to reduce the long-lived component of the radioactive waste, thus easing the waste management problem. A safety case for a repository for wastes from P and T fuel cycles would be different from a safety case that deals with spent fuel and

Including plasma and fusion topics in the science education in school

International Nuclear Information System (INIS)

Kado, Shinichiro

2015-01-01

Yutori education (more relaxed education policy) started with the revision of the Courses of Study to introduce 'five-day week system' in 1989, continued with the reduction of the content of school lessons by 30% in 1998, and ended with the introduction of the New Courses of Study in 2011. Focusing on science education, especially in the topics of plasma and nuclear fusion, the modality of the education system in Japan is discussed considering the transition of academic performance based on the Program for International Student Assessment (PISA) in comparison with the examples in other countries. Particularly, the issues with high school textbooks are pointed out from the assessment of current textbooks, and the significance and the need for including the topic of 'plasma' in them are stated. Lastly, in order to make the general public acknowledged with plasma and nuclear fusion, it is suggested to include them also in junior high school textbooks, by briefly mentioning the terms related to plasma, solar wind, aurora phenomenon, and nuclear fusion energy. (S.K.)

Specialized meeting on 'Current topics of reactor safety research in Germany'

International Nuclear Information System (INIS)

Kruessenberg, Anne

2013-01-01

On October 11 and 12, 2012, the 2-day specialized meeting organized by the Thermodynamics and Fluid Dynamics Group together with the Dresden-Rossendorf Helmholtz Center and TUeV NORD SysTec GmbH and Co.KG was held at the Dresden-Rossendorf Helmholtz Center within the series of events on 'Current Topics of Safety Research in Germany.' The program of lectures was supplemented by poster presentations and exhibitions by the members of the joint research groups and companies working in the fields. The meeting again was very well attended by over 100 persons. (orig.)

Model for safety reports including descriptive examples

International Nuclear Information System (INIS)

1995-12-01

Several safety reports will be produced in the process of planning and constructing the system for disposal of high-level radioactive waste in Sweden. The present report gives a model, with detailed examples, of how these reports should be organized and what steps they should include. In the near future safety reports will deal with the encapsulation plant and the repository. Later reports will treat operation of the handling systems and the repository

Safety performance indicators. Topical issues paper no. 5

International Nuclear Information System (INIS)

Dahlgren, K.; Lederman, L.; Szikszai, T.; Palomo, J.

2001-01-01

performance, they are just one of a larger set of tools including probabilistic safety assessment (PSA), regulatory inspection, quality assurance, external reviews and self-assessment needed to assess operational safety performance. The integration of information compiled from such evaluation tools yields the best results. Two areas of increasingly common interest are 'risk based' indicators, and 'safety culture' indicators. The key to managing the nuclear business today is to establish a high quality safety management system as well as developing a strong safety culture within the entire organization. 'The safety management system comprises those arrangements made by the organization for the management of safety in order to promote a strong safety culture and achieve good safety performance'. This definition, presented in INSAG-13, illustrates the close connection between 'safety management systems' and 'safety culture' and that they are in fact inseparable. To manage safety effectively you need a systematic approach and at the same time be aware of the effects of the approach on individual and collective human behaviour. This issue covers the following: development of safety performance indicators, indicator selection and use, recommended indicators, indicators collected from nuclear power plant initiatives, management of safety and safety culture, need and feasibility of an international system, plant management needs, regulatory use of safety performance indicators, public communication, and recommendations for priorities in future work

Topics on Japanese aseismic design for nuclear installations

International Nuclear Information System (INIS)

Nakamura, Masahiko

2002-01-01

Major items of of Japanese anti-seismic design for nuclear installations involve three topics: earthquakes and ground motion; seismic design and safety evaluation. The first topic deal with: improvement of geological survey technology, evaluation of ground motion from active faults, and characterisation of earthquake from individual faults. Seismic design involves: evaluation of design ground motion (spectra), classification of structures, systems and components (SSCs) based on the seismic importance, and seismic design criteria and critical loads. Safety evaluation of seismic PSA is dependent on the consistency of the the two previous items. Seismic hazard evaluation methodology, database and examples of analysis are described. Analysis method using fault model is included

Efficacy and safety of topical diquafosol ophthalmic solution for treatment of dry eye: a systematic review of randomized clinical trials.

Science.gov (United States)

Wu, Di; Chen, Wang Qi; Li, Ryan; Wang, Yan

2015-06-01

To evaluate the efficacy and safety of topical diquafosol ophthalmic solution for treatment of dry eye. Randomized clinical trials (RCTs) from MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) were identified to evaluate the efficacy and safety of topical administration of diquafosol to patients with dry eyes. Data evaluation was based on endpoints including Schirmer test, tear film break-up time, ocular surface staining score, subjective symptom score, and adverse events. A total of 8 RCTs involving 1516 patients were selected based on the prespecified criteria. Significant improvement of Schirmer test values and tear film break-up time were reported in 40% (2 of 5) and 80% (4 of 5) studies, respectively. Ocular surface staining scores significantly decreased in 100% (fluorescein corneal staining, 6 of 6; Rose Bengal corneal and conjunctival staining, 4 of 4) RCTs. Symptoms significantly improved in 75% (6 of 8) RCTs in patients with dry eyes. No severe adverse events were reported with the concentration of diquafosol from 0.5% to 5%. Heterogeneity in study design prevented meta-analysis from statistical integration and summarization. Topical diquafosol seems to be a safe therapeutic option for the treatment of dry eye. The high variability of the selected RCTs compromised the strength of evidence and limits the determination of efficacy. However, the topical administration of diquafosol seems to be beneficial in improving the integrity of the epithelial cell layer of the ocular surface and mucin secretion in patients with dry eyes. This review indicates a need for standardized criteria and methods for evaluation to assess the efficacy of diquafosol in the future clinical trials.

Efficacy and Safety of Topical Niacinamide for Acne Vulgaris

Directory of Open Access Journals (Sweden)

Zeynep Nurhan Saraçoğlu

2011-06-01

Full Text Available Background and Design: To investigate the efficacy and safety of topical 4% naicinamide gel cream in the treatment of mild to moderate acne vulgaris and to assess the quality of life of acne patients.Material and Method: Twenty-nine female patients aged 16-38 (mean: 23.57±5.42 years with mild to moderate acne vulgaris who presented in dermatology outpatient clinic were enrolled in the study. All patients applied 4% niacinamide gel cream (Vivatinell-acnecinamide gel cream® on their faces twice daily for eight weeks. The number of lesions (inflammatory and non-inflammatory was counted at 0, 2, 4 and 8 weeks. The side effects (erythema, desquamation, burning and dryness were recorded. The Skindex-29, a quality-of-life measure for patients with skin disease, was administered to the subjects at the beginning and the end of treatment.Results: The decrease in the mean number of inflammatory lesions was statistically significant at the end of the treatment (pre-treatment vs. post-treatment: 12.24 vs. 6.14; p =0.000. However, there was no statistically significant decrease in the number of non-inflammatory lesions at the end of the eight weeks. The niacinamide gel cream was generally well tolerated. There was statistically significant improvement in the Skindex-29 scale scores (p =0.000 at the end of the treatment.Conclusion: Topical 4% niacinamide gel cream may be an alternative treatment for inflammatory lesions of mild to moderate acne vulgaris.

Proceedings of the 10th international topical meeting on nuclear thermal hydraulics, operation and safety (NUTHOS-10)

International Nuclear Information System (INIS)

2014-01-01

The 10th International Topical Meeting on Nuclear Thermal Hydraulics, Operations and Safety (NUTHOS-10) in Okinawa, Japan is sponsored by Atomic Energy Society of Japan, in cooperation with the International Atomic Energy Agency, and co-sponsored by American Nuclear Society Thermal Hydraulics Division among others. Enhanced safety and reducing cost are going together, which can be achieved through continued research and development efforts. NUTHOS keeps you abreast of the most updated information in the advancement of science and technology in nuclear thermal hydraulics, operations and safety, and provides you insights into the future. (J.P.N.)

Safety evaluation of topical applications of ethanol on the skin and inside the oral cavity

Directory of Open Access Journals (Sweden)

Lachenmeier Dirk W

2008-11-01

Full Text Available Abstract Ethanol is widely used in all kinds of products with direct exposure to the human skin (e.g. medicinal products like hand disinfectants in occupational settings, cosmetics like hairsprays or mouthwashes, pharmaceutical preparations, and many household products. Contradictory evidence about the safety of such topical applications of the alcohol can be found in the scientific literature, yet an up-to-date risk assessment of ethanol application on the skin and inside the oral cavity is currently lacking. The first and foremost concerns of topical ethanol applications for public health are its carcinogenic effects, as there is unambiguous evidence for the carcinogenicity of ethanol orally consumed in the form of alcoholic beverages. So far there is a lack of evidence to associate topical ethanol use with an increased risk of skin cancer. Limited and conflicting epidemiological evidence is available on the link between the use of ethanol in the oral cavity in the form of mouthwashes or mouthrinses and oral cancer. Some studies pointed to an increased risk of oral cancer due to locally produced acetaldehyde, operating via a similar mechanism to that found after alcoholic beverage ingestion. In addition, topically applied ethanol acts as a skin penetration enhancer and may facilitate the transdermal absorption of xenobiotics (e.g. carcinogenic contaminants in cosmetic formulations. Ethanol use is associated with skin irritation or contact dermatitis, especially in humans with an aldehyde dehydrogenase (ALDH deficiency. After regular application of ethanol on the skin (e.g. in the form of hand disinfectants relatively low but measurable blood concentrations of ethanol and its metabolite acetaldehyde may occur, which are, however, below acute toxic levels. Only in children, especially through lacerated skin, can percutaneous toxicity occur. As there might be industry bias in many studies about the safety of topical ethanol applications, as well

Strengths, weaknesses, opportunities and threats – swot analysis regarding the romanian participation in euratom programmes on nuclear safety topic

International Nuclear Information System (INIS)

Apostol, M.; Constantin, M.; Diaconu, D.

2013-01-01

In the frame of FP7 - NEWLANCER project, SWOT analysis (Strengths, Weaknesses, Opportunities and Threats) was performed by each partner from New Member States (NMS) in order to provide valuable input for the development of policies aimed to increase the participation of the NMS in Euratom programmes on the following topics: Generation III and IV systems and materials, Nuclear safety, Radioprotection, Radioactive waste management, and Education and training. The final objective of SWOT analysis performed by National Expert Groups on Nuclear Safety (NS) topic was to propose strategies, in order to reduce the influence of identified negative factors and to enhance influence of identified positive factors, regarding Romanian participation in Euratom programmes. (authors)

Topical cyclosporine for atopic keratoconjunctivitis.

Science.gov (United States)

González-López, Julio J; López-Alcalde, Jesús; Morcillo Laiz, Rafael; Fernández Buenaga, Roberto; Rebolleda Fernández, Gema

2012-09-12

Ophthalmologica Europaea from 2005 to July 2011. We included randomised controlled trials only. Two review authors independently extracted data. Due to the small number of studies and the diversity of outcome measures, interventions and participants, we presented results narratively. We found three RCTs with a total of 58 participants that were eligible for inclusion. There was significant variability between the trials in interventions, methodology and outcome measures and therefore we did not perform meta-analysis.One study reported on the use of 2% CsA in maize oil and two on the use of a commercial emulsion of 0.05% CsA. Of these three studies, one showed a beneficial effect of topical CsA in controlling signs and symptoms of AKC, one in controlling signs of AKC and one did not show evidence of an improvement. Only two studies analysed the effect of topical CsA in reducing topical steroid use; one showed a significant reduction in topical steroid use with CsA, but the other did not show evidence of this improvement. No serious adverse events were reported in the trials. This systematic review highlights the relative scarcity of controlled clinical trials assessing the efficacy of topical CsA therapy in AKC and suggests that evidence on the efficacy and safety of topical CsA treatment in patients with CsA remains limited. However, the data suggest that topical CsA may provide clinical and symptomatic relief in AKC and may help to reduce topical steroid use in patients with steroid-dependent or steroid-resistant AKC. No serious adverse events were reported. Reported adverse events in patients treated with topical CsA include intense stinging and eyelid skin maceration. One patient in the placebo group developed a severe allergic response to maize antigens. However, the total number of patients in the trials was too small to assess the safety of this treatment.Additional well-designed and powered RCTs of topical CsA in AKC are needed. Ideal study designs should include adequate

Multi Canister Overpack (MCO) Topical Report [SEC 1 THRU 6

International Nuclear Information System (INIS)

GARVIN, L.J.

2002-01-01

In February 1995, the US. Department of Energy (DOE) approved the Spent Nuclear Fuel (SNF) Project's ''Path Forward'' recommendation for resolution of the safety and environmental concerns associated with the deteriorating SNF stored in the Hanford Site's K Basins (Hansen 1995). The recommendation included an aggressive series of projects to design, construct, and operate systems and facilities to permit the safe retrieval, packaging, transport, conditioning, and interim storage of the K Basins' SNF. The facilities are the Cold Vacuum Drying Facility (CVDF) in the 100 K Area of the Hanford Site and the Canister Storage Building (CSB) in the 200 East Area. The K Basins' SNF is to be cleaned, repackaged in multi-canister overpacks (MCOs), removed from the K Basins, and transported to the CVDF for drying. The MCOs would then be moved to the CSB and weld sealed (Loscoe 1996) for interim storage (about 40 years). One of the major tasks associated with the initial Path Forward activities is the development and maintenance of the safety documentation. In addition to meeting the construction needs for new structures, the safety documentation for each must be generated. A common thread that was identified among the structures was the MCO. Each structure exists for the specific purpose of treating or storing the MCO and its contents. Normally, an extensive amount of MCO-related documentation would be generated for each of the facility safety analysis reports. However, the expedited schedule for removing spent fuel from the K Basins requires that the documentation effort be minimized and repetitious activities be eliminated. Therefore, this topical report has been prepared to address those aspects of the MCO that will be common to the facilities. The MCO will be included in each facility's safety documentation by reference to this topical report. By capturing the design of the MCO and its safety evaluation in a single document, repetition, inconsistency, and duplication of

Health Care providers and Teen Driving Safety: Topics Discussed and Educational Resources Used in Practice.

Science.gov (United States)

Dellinger, Ann M; West, Bethany A

2015-11-01

Traffic crashes are the leading cause of death among teens. Health care providers have an opportunity to address what works to keep teens safe on the road during the patient visit. An online survey was conducted of 1088 health care providers who saw patients at or near driving age. The survey assessed which road safety topics were discussed and which types of educational products were used most often. Family and general practice physicians represented 44.3% of the sample, followed by pediatricians (22.5%), nurse practitioners (17.6%), and internists (15.5%). Nearly all respondents (92.9%) reported addressing one or more driving safety factors (seat belt use, nighttime driving, fatigue, teen passengers, alcohol/drug use, speeding/reckless driving, and cell phone use/texting) with adolescent patients and/or their parents. Seat belt use was reported more often (83.7%) than other topics. The use of parent-teen driving agreements, a known effective intervention, was reported by less than 10% of respondents. Since health care providers expressed interest in receiving written resource materials, distribution of parent-teen driving agreements to health care providers might encourage greater uptake and use of this effective intervention.

48{sup th} Annual meeting on nuclear technology (AMNT 2017). Key topic / Enhanced safety and operation excellence. Technical session: Operation and safety of nuclear installations, fuel

Energy Technology Data Exchange (ETDEWEB)

Hollands, Thorsten [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Garching (Germany). Bereich Reaktorsicherheitsforschung

2017-12-15

The sessions Fuel and Materials and Containment and SFP, as part of the Technical Sessions Operation and Safety of Nuclear Installations, Fuel implemented in the Key Topic Enhanced Safety and Operation Excellence were chaired by Dr. Thorsten Hollands (Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH) and Dr. Erwin Fischer (PreussenElektra GmbH) who was the keynote coordinator for the Technical Sessions. Both sessions consist of a keynote lecture followed by technical presentations.

Topical session proceedings of the 6. IGSC Meeting. The role of monitoring in a safety case

International Nuclear Information System (INIS)

2005-01-01

This report summarises the outcomes of a topical session focused on the role of monitoring in a safety case. It was held as part of the 6. plenary meeting of the IGSC. It was attended by 39 participants, representing waste management organisations and regulatory authorities from 15 NEA member countries, the IAEA and the European Commission. The main purpose of this topical session was to create a platform for exchanging views on the key monitoring issues of interest to build confidence in a safety case e.g. relationship with the post-closure phase, functions, requirements, and to determine to what extent the main actions are to be addressed by the IGSC on its ongoing activities on defining the elements of a safety case. The topical session was indeed mainly aimed at exchanging information on: - National strategies or programmes in NEA members' countries. Member countries have organisations planning their own strategy, but some are already, to some extend engaged in implementing monitoring activities, e.g. Posiva Oy, US-DOE-YM, Andra. - Feedback from international projects, e.g. the EC Thematic Network on 'The role of Monitoring in a Phased Approach to Geological Disposal of Radioactive Waste', and the IAEA programme of work. - The expectations of regulators, e.g. SKI. Part A of this document summarises the material orally presented and provides the main lessons drawn from the presentations and the discussions that followed them. The overheads presented are compiled without any further elaboration by the NEA Secretariat as Part B of the document. Part C gives the list of participants. The document as a whole provides a synthesis of current issues in monitoring of a deep geological disposal facility

Internet safety education for youth: stakeholder perspectives.

Science.gov (United States)

Moreno, Megan A; Egan, Katie G; Bare, Kaitlyn; Young, Henry N; Cox, Elizabeth D

2013-06-05

Internet use is nearly ubiquitous among US youth; risks to internet use include cyberbullying, privacy violations and unwanted solicitation. Internet safety education may prevent these negative consequences; however, it is unclear at what age this education should begin and what group is responsible for teaching this topic. Surveys were distributed to key stakeholders in youth safety education including public school teachers, clinicians, parents and adolescents. Surveys assessed age at which internet safety education should begin, as well as experiences teaching and learning internet safety. Surveys of adults assessed willingness to teach internet safety. Finally, participants were asked to identify a group whose primary responsibility it should be to teach internet safety. A total of 356 participants completed the survey (93.4% response rate), including 77 teachers, 111 clinicians, 72 parents and 96 adolescents. Stakeholders felt the optimal mean age to begin teaching internet safety was 7.2 years (SD = 2.5), range 2-15. Internet safety was regularly taught by some teachers (20.8%), few clinicians (2.6%) and many parents (40.3%). The majority of teachers, clinicians and parents were willing to teach internet safety, but all groups surveyed identified parents as having primary responsibility for teaching this topic. Findings suggest agreement among key stakeholders for teaching internet safety at a young age, and for identifying parents as primary teachers of this topic. Clinicians have a unique opportunity to support parents by providing resources, guidance and support.

Tire safety : everything rides on it

Science.gov (United States)

2008-01-01

This booklet presents a comprehensive overview of tire safety, including information on the following topics: basic tire maintenance; Uniform Tire Quality Grading System; fundamental characteristics of tires; and tire safety tips.

Fast reactor safety: proceedings of the international topical meeting. Volume 1

Energy Technology Data Exchange (ETDEWEB)

1985-07-01

The emphasis of this meeting was on the safety-related aspects of fast reactor design, analysis, licensing, construction, and operation. Relative to past meetings, there was less emphasis on the scientific and technological basis for accident assessment. Because of its broad scope, the meeting attracted 217 attendees from a wide cross section of the design, safety analysis, and safety technology communities. Eight countries and two international organizations were represented. A total of 126 papers were presented, with contributions from the United States, France, Japan, the United Kingdom, Germany, and Italy. Sessions covered in Volume 1 include: impact of safety and licensing considerations on fast reactor design; safety aspects of innovative designs; intra-subassembly behavior; operational safety; design accommodation of seismic and other external events; natural circulation; safety design concepts; safety implications derived from operational plant data; decay heat removal; and assessment of HCDA consequences.

Fast reactor safety: proceedings of the international topical meeting. Volume 1

International Nuclear Information System (INIS)

1985-07-01

The emphasis of this meeting was on the safety-related aspects of fast reactor design, analysis, licensing, construction, and operation. Relative to past meetings, there was less emphasis on the scientific and technological basis for accident assessment. Because of its broad scope, the meeting attracted 217 attendees from a wide cross section of the design, safety analysis, and safety technology communities. Eight countries and two international organizations were represented. A total of 126 papers were presented, with contributions from the United States, France, Japan, the United Kingdom, Germany, and Italy. Sessions covered in Volume 1 include: impact of safety and licensing considerations on fast reactor design; safety aspects of innovative designs; intra-subassembly behavior; operational safety; design accommodation of seismic and other external events; natural circulation; safety design concepts; safety implications derived from operational plant data; decay heat removal; and assessment of HCDA consequences

Safety implications of electronic driving support systems : an orientation.

NARCIS (Netherlands)

Gundy, C.M. Steyvers, F.J.J.M. & Kaptein, N.A.

1995-01-01

This report focuses on traffic safety aspects of driving support systems. The report consists of two parts. First of all, the report discusses a number of topics, relevant for the implementation and evaluation of driving support systems. These topics include: (1) safety research into driving support

Effectiveness and safety of topical tacrolimus in treatment of vitiligo

Directory of Open Access Journals (Sweden)

Ghasem Rahmatpour Rokni

2017-01-01

Full Text Available Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant′s evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system. Photography and depigmentation percent has recorded before treatment and further in 4 th , 8 th , 12 th , 16 th , 20 th , and 24 th weeks. Finally, gathered data compared through SPSS-20 software. The final sample comprised 30 persons including: 12 men (40% and 18 women (60%. The average of patient′s age in this study was 26/13 ΁ 18/20 (2-76-year-old. Eleven persons was ≤15 years old and rest was older than 15. Sixty-six lesions have funded in patients that maximum has accrued on face and neck (37/87% and trunk (21/21%. In addition, minimum of lesions is related to genitalia (9/09%. In the in 4 th , 8 th , 12 th , 16 th weeks, improvement in face and neck had increased significantly, into the past weeks. In the 20 th and 24 th weeks, the improvement has increased although it was not significant enhancement. Also about trunk, in the 4 th week the improvement does not have significant increasing in compare to the past week. In the eighth, 12 th , 16 th , 20 th , and 24 th weeks the improvement has been increased significantly in compare to the past weeks. Although in the case of limbs and genitalia, the improvement was lower. There was no significant difference between male and females and age. Although the improvement was, slow in older persons. Study results, has presented applying topical tacrolimus in vitiligo, particularly in face and neck, could be effective and

Patient safety in undergraduate radiography curricula: A European perspective

International Nuclear Information System (INIS)

England, A.; Azevedo, K.B.; Bezzina, P.; Henner, A.; McNulty, J.P.

2016-01-01

Purpose: To establish an understanding of patient safety within radiography education across Europe by surveying higher education institutions registered as affiliate members of the European Federation of Radiographer Societies (EFRS). Method: An online survey was developed to ascertain data on: programme type, patient safety definitions, relevant safety topics, specific areas taught, teaching and assessment methods, levels of teaching and curriculum drivers. Responses were identifiable in terms of educational institution and country. All 54 affiliated educational institutions were invited to participate. Descriptive and thematic analyses are reported. Results: A response rate of 61.1% (n = 33) was achieved from educational institutions representing 19 countries. Patient safety topics appear to be extremely well covered across curricula, however, topics including radiation protection and optimisation were not reported as being taught at an ‘advanced level’ by five and twelve respondents, respectively. Respondents identified the clinical department as the location of most patient safety-related teaching. Conclusions: Patient safety topics are deeply embedded within radiography curricula across Europe. Variations exist in terms of individual safety topics including, teaching and assessment methods, and the depth in which subjects are taught. Results from this study provide a baseline for assessing developments in curricula and can also serve as a benchmark for comparisons. - Highlights: • First European report on patient safety (PS). • PS deeply embedded within training curricula. • Terms and definitions largely consistent. • Some variety in the delivery and assessment methods. • Report provides baseline and opportunities for comparisons.

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Bohnstedt, Angelika [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Programm Nukleare Entsorgung, Sicherheit und Strahlenforschung (NUSAFE); Baumann, Erik [AREVA GmbH, Erlangen (Germany). Radiation Protection

2016-12-15

Summary report on the Key Topic 'Enhanced Safety and Operation Excellence' Focus Session 'Radiation Protection' of the 47{sup th} Annual Meeting on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

Workplace Safety and Health Topics: Safety & Prevention

Science.gov (United States)

... 1, 2018 Content source: National Institute for Occupational Safety and Health Education and Information Division Email Recommend Tweet YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs Funding LEGAL Policies Privacy FOIA No Fear Act OIG 1600 Clifton Road Atlanta , GA 30329-4027 USA 800-CDC-INFO ( ...

The role of international atomic energy agency in maintaining nuclear safety competence

International Nuclear Information System (INIS)

Aro, I.; Mazour, T.

2000-01-01

This paper provides information how International Atomic Energy Agency can assist Member States in maintaining and developing nuclear safety competence. The topics covered include the development of safety standards, organisation of nuclear safety related conferences, provision of safety reviews, organisation of training courses and topical workshops and publication of training related documents. Usefulness of these activities for competence development is discussed. (author)

Safety in the Chemical Laboratory: An Undergraduate Chemical Laboratory Safety Course.

Science.gov (United States)

Nicholls, L. Jewel

1982-01-01

Describes a two-quarter hour college chemistry course focusing on laboratory safety. Includes lists of topics/assignments, problem sets (toxicology, storage, and energy) and videotapes, films, and slide sets used in the course. (JN)

Fast reactor safety: proceedings of the international topical meeting. Volume 2

International Nuclear Information System (INIS)

1985-07-01

The emphasis of this meeting was on the safety-related aspects of fast reactor design, analysis, licensing, construction, and operation. Relative to past meetings, there was less emphasis on the scientific and technological basis for accident assessment. Because of its broad scope, the meeting attracted 217 attendees from a wide cross section of the design, safety analysis, and safety technology communities. Eight countries and two international organizations were represented. A total of 126 papers were presented, with contributions from the United States, France, Japan, the United Kingdom, Germany, and Italy. Sessions covered in Volume 2 include: safety design concepts; operational transient experiments; analysis of seismic and external events; HCDA-related codes, analysis, and experiments; sodium fires; instrumentation and control/PPS design; whole-core accident analysis codes; and impact of safety design considerations on future LMFBR developments

30 CFR 285.810 - What must I include in my Safety Management System?

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What must I include in my Safety Management System? 285.810 Section 285.810 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR..., COPs and GAPs Safety Management Systems § 285.810 What must I include in my Safety Management System...

Topic modelling in the information warfare domain

CSIR Research Space (South Africa)

De Waal, A

2013-11-01

Full Text Available for interesting and relevant topics. The objectives of this paper is to describe topic modelling, put it in context as a useful IW technique and illustrate its use with two examples. They discuss several applications of topic modelling in the safety and security...

Ferrocyanide Safety Program rationale for removing six tanks from the safety watch list

International Nuclear Information System (INIS)

Borsheim, G.L.

1993-09-01

This report documents an in-depth study of single-shell tanks containing ferrocyanide wastes. Topics include: safety assessments, tank histories, supportive documentation about interim stabilization and planned remedial activities

Nuclear safety after Three Mile Island and Chernobyl

International Nuclear Information System (INIS)

Ballard, G.M.

1988-01-01

This book contains the proceedings on nuclear safety after Three Mile island and Chernobyl. Topics covered include: Design for safety; Man-machine interaction; Source terms and consequence; and accident response

Safety and Health Topics: Asbestos

Science.gov (United States)

... Safety and Health Program Recommendations It's the Law Poster REGULATIONS Law and Regulations Standard Interpretations Training Requirements ... page requires that javascript be enabled for some elements to function correctly. Please contact the OSHA Directorate ...

Problems of nuclear reactor safety. Vol. 2

International Nuclear Information System (INIS)

Goncharov, L.A.

1995-01-01

Theses of proceedings of the 9 Topical Meeting on problems of nuclear power plant safety are presented. Reports include results of neutron-physical experiments carried out for reactor safety justification. Concepts of advanced reactors with improved safety are considered. Results of researches on fuel cycles are given too

CloudSat Safety Operations at Vandenberg AFB

Science.gov (United States)

Greenberg, Steve

2006-01-01

CloudSat safety operations at Vendenberg AFB is given. The topics include: 1) CloudSat Project Overview; 2) Vandenberg Ground Operations; 3) Delta II Launch Vehicle; 4) The A-Train; 5) System Safety Management; 6) CALIPSO Hazards Assessment; 7) CALIPSO Supplemental Safeguards; 8) Joint System Safety Operations; 9) Extended Stand-down; 10) Launch Delay Safety Concerns; and 11) Lessons Learned.

Liposomal topical capsaicin in post-herpetic neuralgia: a safety pilot study

Directory of Open Access Journals (Sweden)

Manoel Jacobsen Teixeira

2015-03-01

Full Text Available Topical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events. Objective To evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC (0.025% in patients with post herpetic neuralgia (PHN. Method Patients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment. Results Thirteen patients completed both treatment periods. Visual Analog Scale (VAS was significantly decreased after the end of the study (p = 0.008, however the effect of treatment was not significant (p = 0.076. There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.

Integrated model of port oil piping transportation system safety including operating environment threats

Directory of Open Access Journals (Sweden)

Kołowrocki Krzysztof

2017-06-01

Full Text Available The paper presents an integrated general model of complex technical system, linking its multistate safety model and the model of its operation process including operating environment threats and considering variable at different operation states its safety structures and its components safety parameters. Under the assumption that the system has exponential safety function, the safety characteristics of the port oil piping transportation system are determined.

Integrated model of port oil piping transportation system safety including operating environment threats

OpenAIRE

Kołowrocki, Krzysztof; Kuligowska, Ewa; Soszyńska-Budny, Joanna

2017-01-01

The paper presents an integrated general model of complex technical system, linking its multistate safety model and the model of its operation process including operating environment threats and considering variable at different operation states its safety structures and its components safety parameters. Under the assumption that the system has exponential safety function, the safety characteristics of the port oil piping transportation system are determined.

IAEA safety glossary. Terminology used in nuclear safety and radiation protection, multilingual 2007 edition, including the IAEA safety fundamentals [no. SF-1

International Nuclear Information System (INIS)

2008-10-01

The IAEA Safety Glossary defines and explains technical terms used in the IAEA Safety Standards and other safety related IAEA publications, and provides information on their usage.The publication is multilingual and covers the six official IAEA languages,, Arabic, Chinese, English, French, Russian and Spanish. It has been in use since April 2000. The 2007 Edition is a revised and updated version. The primary purpose of the publication is to harmonize terminology and usage in the IAEA Safety Standards. It is a source of information for users of the IAEA Safety Standards and other safety related IAEA publications and provides guidance for the drafters and reviewers of publications, including IAEA technical officers and consultants, and members of technical committees, advisory groups, working groups and bodies for the endorsement of safety standards

Nuclear safety research

International Nuclear Information System (INIS)

1996-01-01

The topics 'Large-sized PWR-NPP Safety Techniques Research',and 'The Key Techniques Research on the Safety Supervision and Control for Operation of Nuclear Installations' have been adopted as an apart of 'the National 9th five Year Programs for Tacking the Key Scientific and Technical Topics' which are organized by the State Planning Commission (SPC) and State Science and Technology Commission (SSTC) respectively, and have obtained a financial support from them. To play a better role with the limited fund, the NNSA laid special stress on selecting key sub-topics on nuclear safety, and carefully choosing units which would undertake sub-topics and signing technical contracts with them

Fast reactor safety: proceedings of the international topical meeting. Volume 2. [R

Energy Technology Data Exchange (ETDEWEB)

1985-07-01

The emphasis of this meeting was on the safety-related aspects of fast reactor design, analysis, licensing, construction, and operation. Relative to past meetings, there was less emphasis on the scientific and technological basis for accident assessment. Because of its broad scope, the meeting attracted 217 attendees from a wide cross section of the design, safety analysis, and safety technology communities. Eight countries and two international organizations were represented. A total of 126 papers were presented, with contributions from the United States, France, Japan, the United Kingdom, Germany, and Italy. Sessions covered in Volume 2 include: safety design concepts; operational transient experiments; analysis of seismic and external events; HCDA-related codes, analysis, and experiments; sodium fires; instrumentation and control/PPS design; whole-core accident analysis codes; and impact of safety design considerations on future LMFBR developments.

Safety of Nuclear Fuel Cycle Facilities. Safety Requirements (Arabic Edition)

International Nuclear Information System (INIS)

2015-01-01

This publication covers the broad scope of requirements for fuel cycle facilities that, in light of the experience and present state of technology, must be satisfied to ensure safety for the lifetime of the facility. Topics of specific relevance include aspects of nuclear fuel generation, storage, reprocessing and disposal

Evaluation of the activity and safety of CS21 barrier genital gel® compared to topical aciclovir and placebo in symptoms of genital herpes recurrences: a randomized clinical trial.

Science.gov (United States)

Khemis, A; Duteil, L; Tillet, Y; Dereure, O; Ortonne, J-P

2014-09-01

Topical or systemic antiviral drugs reduce the duration of genital herpes recurrences but may not always alleviate functional symptoms. To assess the efficacy and safety of oxygenated glycerol triesters-based CS21 barrier genital gel(®) vs. topical aciclovir and placebo (vehicle) in resolving functional symptoms and in healing of genital herpes recurrences. A prospective randomized controlled, investigator-blinded trial of CS21 barrier genital gel(®) vs. topical aciclovir (reference treatment) and placebo (vehicle) was designed. The primary endpoint was the cumulative score of four herpes-related functional symptoms (pain, burning, itching and tingling sensations). Secondary endpoints included objective skin changes (erythema, papules, vesicles, oedema, erosion/ulceration, crusts), time to heal, local tolerance and overall acceptability of the treatment as reported by a self-administered questionnaire. Overall, 61 patients were included. CS 21 barrier genital gel(®) was significantly more efficient than topical aciclovir and vehicle for subjective symptoms and pain relief in genital herpes recurrences; additionally, time to heal was significantly shorter with CS 21 than with vehicle, whereas no significantly difference was observed between patients receiving topical aciclovir and vehicle. The treatments under investigation were well tolerated and the adverse events were comparable in the three treatment groups. Overall, these results support the interest of using of CS 21 barrier genital gel(®) in symptomatic genital herpes recurrences. Accordingly, this product offers a valuable alternative in topical management of recurrent genital herpes. © 2013 European Academy of Dermatology and Venereology.

48{sup th} Annual meeting on nuclear technology (AMNT 2017). Key topic / Enhanced safety and operation excellence. Focus session: International operational experience

Energy Technology Data Exchange (ETDEWEB)

Mohrbach, Ludger [VGB PowerTech e.V., Essen (Germany). Abteilung ' ' N' ' ; Gottschling, Helge

2017-11-15

Summary report on the Key Topic Enhanced Safety and Operation Excellence: Focus Session: International Operational Experience and the Nuclear Energy Campus of the 48{sup th} Annual Meeting on Nuclear Technology (AMNT 2017) held in Berlin, 16 to 17 May 2017.

Safety implications of electronic driving support systems : an orientation.

OpenAIRE

Gundy, C.M. Steyvers, F.J.J.M. & Kaptein, N.A.

1995-01-01

This report focuses on traffic safety aspects of driving support systems. The report consists of two parts. First of all, the report discusses a number of topics, relevant for the implementation and evaluation of driving support systems. These topics include: (1) safety research into driving support systems: (2) the importance of research into driver models and the driving task; (3) horizontal integration of driving support systems; (4) vertical integration of driving support systems; (5) tas...

Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys.

Science.gov (United States)

Rannou, François; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne

2016-02-01

Topical non-steroidal anti-inflammatory drugs (NSAIDs) are recommended in international and national guidelines as an early treatment option for the symptomatic management of knee and hand osteoarthritis (OA), and may be used ahead of oral NSAIDs due to their superior safety profile. The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends topical NSAIDs for knee OA in addition to the pharmacological background of symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) and rescue analgesia with paracetamol and non-pharmacological treatment, if the patient is still symptomatic. Topical NSAIDs have a moderate effect on pain relief, with efficacy similar to that of oral NSAIDs, with the advantage of a better risk:benefit ratio. In real-life studies, topical and oral NSAIDs demonstrate an equivalent effect on knee pain over 1 year of treatment, with fewer adverse events due to lower systemic absorption of topical NSAIDs compared with oral NSAIDs. As a result, topical NSAIDs may be the preferred treatment option, especially in OA patients aged ≥75 years, and those with co-morbidities or at an increased risk of cardiovascular, gastrointestinal, or renal side effects. Furthermore, using topical NSAIDs in inflammatory rheumatic diseases leads to a 40% reduction in the need for concomitant oral NSAIDs. When selecting a topical NSAID, absorption and bioavailability are important because of heterogeneity among topical drug formulations. Molecules like etofenamate have a bioavailability of >20% and evidence for accumulation in synovial tissues, with efficacy demonstrated as improvement in pain and function in real-life studies of OA patients. Diclofenac also shows good efficacy alongside evidence that diclofenac accumulates in the synovium. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

Efficacy and safety of 5% minoxidil topical foam in male pattern hair loss treatment and patient satisfaction.

Science.gov (United States)

Hasanzadeh, Hournaz; Nasrollahi, Saman Ahmad; Halavati, Nader; Saberi, Maryam; Firooz, Alireza

2016-09-01

Male pattern hair loss is widespread around the world. Its prevalence indicates the importance of finding the best treatment modalities. This study evaluates the efficacy and safety of minoxidil 5% topical foam in male pattern hair loss treatment and patient satisfaction. This study was a before-and-after trial on 17 male patients with male pattern hair loss. Subjects were instructed to apply one capful (1 ml) of minoxidil 5% topical foam on the scalp daily for 6 months. Efficacy was assessed through hair counts, subject assessment, and global photographic review. Seventeen male volunteers were recruited, and three volunteers were withdrawn; 14 participated in the trial for 16 weeks, and 12 continued up to 24 weeks. The average hair count with a camera at week 16 (181.87 ± 52.42) and week 24 (194.58 ± 62.82) and with an eye count at week 16 (62.57 ± 15.28) and week 24 (69.91 ± 15.61) increased significantly compared to the baseline after intervention. This study confirmed that minoxidil 5% topical foam is a safe and effective treatment for MPHL. The effect of it is evident after 24 weeks of use.

Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials.

Science.gov (United States)

Deng, Zhen-Han; Zeng, Chao; Yang, Ye; Li, Yu-Sheng; Wei, Jie; Yang, Tuo; Li, Hui; Lei, Guang-Hua

2016-05-01

The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. A comprehensive literature search, covering the databases of Medline, the Cochrane Central Register of Controlled Trials, and EMBASE, was conducted in September 2014 to identify the randomized controlled trials which adopted the topical diclofenac therapy for OA. A total of nine papers were included in this meta-analysis. Topical diclofenac appears to be effective in both pain relief (standard mean differences (SMD) = 0.40; 95 % confidence interval (CI) 0.19 to 0.62; P = 0.0003) and function improvement (SMD = 0.23; 95 % CI 0.03 to 0.43; P = 0.03) when compared with the control group. The sensitivity analysis and subgroup analysis showed that the result of pain intensity was stable and reliable, while the result of physical function improvement was vague. With respect to safety, topical diclofenac demonstrated a higher incidence of adverse events such as dry skin, rash, dermatitis, neck pain, and withdrawal. Topical diclofenac is effective in pain relief as a treatment of OA. It may also have a potential effect in function improvement, which needs further studies to be explored. Although, some adverse effects were observed in the application of topical diclofenac, none of them was serious.

Patient safety education at Japanese medical schools: results of a nationwide survey.

Science.gov (United States)

Maeda, Shoichi; Kamishiraki, Etsuko; Starkey, Jay

2012-05-10

Patient safety education, including error prevention strategies and management of adverse events, has become a topic of worldwide concern. The importance of the patient safety is also recognized in Japan following two serious medical accidents in 1999. Furthermore, educational curriculum guideline revisions in 2008 by relevant the Ministry of Education includes patient safety as part of the core medical curriculum. However, little is known about the patient safety education in Japanese medical schools partly because a comprehensive study has not yet been conducted in this field. Therefore, we have conducted a nationwide survey in order to clarify the current status of patient safety education at medical schools in Japan. Response rate was 60.0% (n = 48/80). Ninety-eight-percent of respondents (n = 47/48) reported integration of patient safety education into their curricula. Thirty-nine percent reported devoting less than five hours to the topic. All schools that teach patient safety reported use of lecture based teaching methods while few used alternative methods, such as role-playing or in-hospital training. Topics related to medical error theory and legal ramifications of error are widely taught while practical topics related to error analysis such as root cause analysis are less often covered. Based on responses to our survey, most Japanese medical schools have incorporated the topic of patient safety into their curricula. However, the number of hours devoted to the patient safety education is far from the sufficient level with forty percent of medical schools that devote five hours or less to it. In addition, most medical schools employ only the lecture based learning, lacking diversity in teaching methods. Although most medical schools cover basic error theory, error analysis is taught at fewer schools. We still need to make improvements to our medical safety curricula. We believe that this study has the implications for the rest of the world as a

Patient safety education at Japanese medical schools: results of a nationwide survey

Directory of Open Access Journals (Sweden)

Maeda Shoichi

2012-05-01

Full Text Available Abstract Background Patient safety education, including error prevention strategies and management of adverse events, has become a topic of worldwide concern. The importance of the patient safety is also recognized in Japan following two serious medical accidents in 1999. Furthermore, educational curriculum guideline revisions in 2008 by relevant the Ministry of Education includes patient safety as part of the core medical curriculum. However, little is known about the patient safety education in Japanese medical schools partly because a comprehensive study has not yet been conducted in this field. Therefore, we have conducted a nationwide survey in order to clarify the current status of patient safety education at medical schools in Japan. Results Response rate was 60.0% (n = 48/80. Ninety-eight-percent of respondents (n = 47/48 reported integration of patient safety education into their curricula. Thirty-nine percent reported devoting less than five hours to the topic. All schools that teach patient safety reported use of lecture based teaching methods while few used alternative methods, such as role-playing or in-hospital training. Topics related to medical error theory and legal ramifications of error are widely taught while practical topics related to error analysis such as root cause analysis are less often covered. Conclusions Based on responses to our survey, most Japanese medical schools have incorporated the topic of patient safety into their curricula. However, the number of hours devoted to the patient safety education is far from the sufficient level with forty percent of medical schools that devote five hours or less to it. In addition, most medical schools employ only the lecture based learning, lacking diversity in teaching methods. Although most medical schools cover basic error theory, error analysis is taught at fewer schools. We still need to make improvements to our medical safety curricula. We believe that this

Safety of nuclear fuel cycle facilities. Safety requirements

International Nuclear Information System (INIS)

2008-01-01

This publication covers the broad scope of requirements for fuel cycle facilities that, in light of the experience and present state of technology, must be satisfied to ensure safety for the lifetime of the facility. Topics of specific reference include aspects of nuclear fuel generation, storage, reprocessing and disposal. Contents: 1. Introduction; 2. The safety objective, concepts and safety principles; 3. Legal framework and regulatory supervision; 4. The management system and verification of safety; 5. Siting of the facility; 6. Design of the facility; 7. Construction of the facility; 8. Commissioning of the facility; 9. Operation of the facility; 10. Decommissioning of the facility; Appendix I: Requirements specific to uranium fuel fabrication facilities; Appendix II: Requirements specific to mixed oxide fuel fabrication facilities; Appendix III: Requirements specific to conversion facilities and enrichment facilities

NS [Nuclear Safety] update. Current safety and security activities and developments taking place in the Department of Nuclear Safety and Security, Issue no. 11, June 2009

International Nuclear Information System (INIS)

2009-06-01

The current issue presents information about the following topics: Nuclear Safety Review for the Year 2008; Feedback from IRS Topical Studies and Events Applied to Safety Standards; Education and Training Programmes at the IAEA Department of Nuclear Safety and Security; Peer Review of Operational Safety Performance (PROSPER)

Proceedings of the Topical Meeting on the safety of nuclear fuel cycle intermediate storage facilities

International Nuclear Information System (INIS)

1998-01-01

The CSNI Working Group on Fuel Cycle Safety held an International Topical Meeting on safety aspects of Intermediate Storage Facilities in Newby Bridge, England, from 28 to 30 October 1997. The main purpose of the meeting was to provide a forum for the exchange of information on the technical issues on the safety of nuclear fuel cycle facilities (intermediate storage). Titles of the papers are: An international view on the safety challenges to interim storage of spent fuel. Interim storage of intermediate and high-level waste in Belgium: a description and safety aspects. Encapsulated intermediate level waste product stores at Sellafield. Safety of interim storage facilities of spent fuel: the international dimension and the IAEA's activities. Reprocessing of irradiated fuel and radwaste conditioning at Belgoprocess site: an overview. Retrieval of wastes from interim storage silos at Sellafield. Outline of the fire and explosion of the bituminization facility and the activities of the investigation committee (STAIJAERI). The fire and explosion incident of the bituminization facility and the lessons learned from the incident. Study on the scenario of the fire incident and related analysis. Study on the scenario of the explosion incident and related analysis. Accident investigation board report on the May 14, 1997 chemical explosion at the plutonium reclamation facility, Hanford site, Richland, Washington. Dry interim storage of spent nuclear fuel elements in Germany. Safe and effective system for the bulk receipt and storage of light water reactor fuel prior to reprocessing. Receiving and storage of glass canisters at vitrified waste storage center of Japan Nuclear Fuel Ltd. Design and operational experience of dry cask storage systems. Sellafield MOX plant; Plant safety design (BNFL). The assessment of fault studies for intermediate term waste storage facilities within the UK nuclear regulatory regime. Non-active and active commissioning of the thermal oxide

Summary record of the topical session of 16. Meeting of the IGSC

International Nuclear Information System (INIS)

Van Luik, Abe; Smith, Paul

2014-01-01

The sixteenth meeting of the Integration Group for the Safety case (IGSC) included a topical session titled: Handling extreme geological events in safety cases during the post-closure phase. The session included nine presentations on the handling of such events by various national programs, questions and answers on each presentation and ended with a general discussion period. The present document summarises the outcome of the meeting. The document is structured as follows: - Section 2 describes the types of extreme geological events discussed in the session and how these are identified, - Section 3 discusses the measures that can be taken to avoid such events and to mitigate their impact on repositories, - Section 4 describes how the likelihood and consequences of events are assessed, - Section 5 address experiences regarding interactions with regulators and other stakeholders, - Section 6 covers remaining issues and planned R and D to address these, and - Section 7 presents a recommendation for possible future collaborative work on this topic

Promoting safety in nuclear installations. The IAEA has established safety standards for nuclear reactors and provides expert review and safety services to assist Member States in their application

International Nuclear Information System (INIS)

2002-01-01

More than 430 nuclear power plants (NPPs) are currently operating in 30 countries around the world. The nuclear share of total electricity production ranges from about 20 percent in the Czech Republic and United States to nearly 78 percent in France and Lithuania. Worldwide, nuclear power generates about 16% of the total electricity. The safety of such nuclear installations is fundamental. Every aspect of a power plant must be closely supervised and scrutinized by national regulatory bodies to ensure safety at every phase. These aspects include design, construction, commissioning, trial operation, commercial operation, repair and maintenance, plant upgrades, radiation doses to workers, radioactive waste management and, ultimately, plant decommissioning. Safety fundamentals comprise defence-in-depth, which means having in place multiple levels of protection. nuclear facilities; regulatory responsibility; communicating with the public; adoption of the international convention on nuclear safety including implementation of IAEA nuclear safety standards. This publication covers topics of designing for safety (including safety concepts, design principles, and human factors); operating safety (including safety culture and advance in operational safety); risk assessment and management

Prospects for nuclear safety research

Energy Technology Data Exchange (ETDEWEB)

Beckjord, E.S.

1995-04-01

This document is the text of a paper presented by Eric S. Beckjord (Director, Nuclear Regulatory Research/NRC) at the 22nd Water Reactor Safety Meeting in Bethesda, MD in October 1994. The following topics are briefly reviewed: (1) Reactor vessel research, (2) Probabilistic risk assessment, (3) Direct containment heating, (4) Advanced LWR research, (5) Nuclear energy prospects in the US, and (6) Future nuclear safety research. Subtopics within the last category include economics, waste disposal, and health and safety.

Food Safety: MedlinePlus Health Topic

Science.gov (United States)

... Food and Drug Administration) Also in Spanish Animal Cloning and Food Safety (Food and Drug Administration) Chemicals ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated ...

Twenty-third water reactor safety information meeting: Volume 2, Human factors research; Advanced I and C hardware and software; Severe accident research; Probabilistic risk assessment topics; Individual plant examination: Proceedings

Energy Technology Data Exchange (ETDEWEB)

Monteleone, S. [comp.] [Brookhaven National Lab., Upton, NY (United States)

1996-03-01

This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 2, present topics in human factors research, advanced instrumentation and control hardware and software, severe accident research, probabilistic risk assessment, and individual plant examination. Individual papers have been cataloged separately.

Patient safety in the care of mentally ill people in Switzerland: Action plan 2016

Science.gov (United States)

Richard, Aline; Mascherek, Anna C; Schwappach, David L B

2017-01-01

Background: Patient safety in mental healthcare has not attracted great attention yet, although the burden and the prevalence of mental diseases are high. The risk of errors with potential for harm of patients, such as aggression against self and others or non-drug treatment errors is particularly high in this vulnerable group. Aim: To develop priority topics and strategies for action to foster patient safety in mental healthcare. Method: The Swiss patient safety foundation together with experts conducted round table discussions and a Delphi questionnaire to define topics along the treatment pathway, and to prioritise these topics. Finally, fields of action were developed. Results: An action plan was developed including the definition and prioritization of 9 topics where errors may occur. A global rating task revealed errors concerning diagnostics and structural errors as most important. This led to the development of 4 fields of action (awareness raising, research, implementation, and education and training) including practice-oriented potential starting points to enhance patient safety. Conclusions: The action plan highlights issues of high concern for patient safety in mental healthcare. It serves as a starting point for the development of strategies for action as well as of concrete activities.

Problems of nuclear reactor safety. Vol. 1

International Nuclear Information System (INIS)

Shal'nov, A.V.

1995-01-01

Proceedings of the 9. Topical Meeting 'Problems of nuclear reactor safety' are presented. Papers include results of studies and developments associated with methods of calculation and complex computerized simulation for stationary and transient processes in nuclear power plants. Main problems of reactor safety are discussed as well as rector accidents on operating NPP's are analyzed

Assessment of the effectiveness of topical propranolol 4% gel for infantile hemangiomas.

Science.gov (United States)

Mashiah, Jacob; Kutz, Ana; Rabia, Smail Hadj; Ilan, Efrat Bar; Goldberg, Ilan; Sprecher, Eli; Harel, Avikam

2017-02-01

Infantile hemangiomas (IHs) are the most common vascular tumors in children. Because of their benign character and natural involution, the vast majority of IHs do not require any treatment. In the past few years, topical beta blockers have been reported to be an effective treatment of superficial IHs. We sought to evaluate the clinical effectiveness and safety profile of topical propranolol 4% gel for the treatment of IHs. A retrospective study of all cases of IHs treated with topical propranolol 4% gel between 2013 and 2015 was performed. All patients were evaluated in a pediatric dermatology unit of a tertiary medical center. Epidemiologic, clinical, and treatment data, including effectiveness score and safety, were reviewed. The study included 63 patients with a total of 75 IHs. Of the total number of IHs, 43 (57.3%) showed a good response to treatment, 19 (25.3%) a partial response, and 13 (17.33%) poor or no response, thus 62 (82.6%) had good or partial response to treatment. Age at treatment initiation, treatment time, thickness of the superficial component, and size of the lesions were shown to predict response to therapy. Out of the entire examined group, only two patients reported minor local side effects manifested by irritation, redness, and scaling of the treated area. No systemic adverse effects were reported. This is an uncontrolled retrospective study. Propranolol 4% gel is a safe and efficient topical therapy for IH. © 2017 The International Society of Dermatology.

Workplace Safety and Health Topics: Industries and Occupations

Science.gov (United States)

... Submit Search The CDC The National Institute for Occupational Safety and Health (NIOSH) Note: Javascript is disabled or is not ... September 6, 2017 Content source: National Institute for Occupational Safety and Health Education and Information Division Email Recommend Tweet YouTube ...

The main requirements of the International Basic Safety Standards

International Nuclear Information System (INIS)

Webb, G.A.M.

1998-01-01

The main requirements of the new international basic safety standards are discussed, including such topics as health effects of ionizing radiations, the revision of basic safety standards, the requirements for radiation protection practices, the requirements for intervention,and the field of regulatory infrastructures. (A.K.)

Safety of Bottled Water Beverages Including Flavored Water and Nutrient-Added Water Beverages

Science.gov (United States)

... Food Resources for You Consumers FDA Regulates the Safety of Bottled Water Beverages Including Flavored Water and Nutrient-Added Water Beverages ... addition, the flavorings and nutrients added to these beverages must comply with all applicable FDA safety requirements and they must be identified in the ...

Fire and explosion safety in the petroleum sector

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

The conference has 13 presentations in topics on LNG projects nationally and internationally, simulations of gas dispersion due to LNG discharges, transports of pressurized natural gas, technological aspects of fire protection and combat equipment, safety aspects of offshore installations and transportation systems, offshore platform and transportation systems design and various examples of safety design and management. Some experiences within safety engineering in the petroleum exploitation are included.

46th Annual meeting on nuclear technology (AMNT 2015). Key topic / Enhanced safety and operation excellence / Sustainable reactor operation management - safe, efficient, valuable

International Nuclear Information System (INIS)

Fischer, Erwin

2015-01-01

Summary report on the following Topical Session of the 46 th Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015: - Sustainable Reactor Operation Management - Safe, Efficient, Valuable (Erwin Fischer) The other Sessions of the Key Topics - ''Outstanding Know-How and Sustainable Innovations'', - ''Enhanced Safety and Operation Excellence'' and - ''Decommissioning Experience and Waste Management Solutions'' have been covered in atw 7 (2015) and will be covered in further issues of atw.

Efficacy and safety of combinations of first-line topical treatments in chronic plaque psoriasis: a systematic literature review

NARCIS (Netherlands)

Hendriks, A.G.M.; Keijsers, R.R.M.C.; Jong, E.M.G.J. de; Seyger, M.M.B.; Kerkhof, P.C.M. van de

2013-01-01

Background Most psoriasis patients suffering from mild to moderate disease are treated with first-line topical treatments, including corticosteroids, vitamin D analogues, topical retinoids and calcineurin inhibitors. Although evidence-based guidelines on combinations are lacking, the majority of

Fire safety engineering

International Nuclear Information System (INIS)

Smith, D.N.

1989-01-01

The periodic occurrence of large-scale, potentially disastrous industrial accidents involving fire in hazardous environments such as oilwell blowouts, petrochemical explosions and nuclear installations highlights the need for an integrated approach to fire safety engineering. Risk reduction 'by design' and rapid response are of equal importance in the saving of life and property in such situations. This volume of papers covers the subject thoroughly, touching on such topics as hazard analysis, safety design and testing, fire detection and control, and includes studies of fire hazard in the context of environment protection. (author)

Topical safety analysis report for the transportation of the NUHOMS reg-sign dry shielded canister

International Nuclear Information System (INIS)

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS reg-sign) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS reg-sign DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS reg-sign Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport

Summary of NRC LWR safety research programs on fuel behavior, metallurgy/materials and operational safety

International Nuclear Information System (INIS)

Bennett, G.L.

1979-09-01

The NRC light-water reactor safety-research program is part of the NRC regulatory program for ensuring the safety of nuclear power plants. This paper summarizes the results of NRC-sponsored research into fuel behavior, metallurgy and materials, and operational safety. The fuel behavior research program provides a detailed understanding of the response of nuclear fuel assemblies to postulated off-normal or accident conditions. Fuel behavior research includes studies of basic fuel rod properties, in-reactor tests, computer code development, fission product release and fuel meltdown. The metallurgy and materials research program provides independent confirmation of the safe design of reactor vessels and piping. This program includes studies on fracture mechanics, irradiation embrittlement, stress corrosion, crack growth, and nondestructive examination. The operational safety research provides direct assistance to NRC officials concerned with the operational and operational-safety aspects of nuclear power plants. The topics currently being addressed include qualification testing evaluation, fire protection, human factors, and noise diagnostics

Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial.

Science.gov (United States)

Bissonnette, R; Papp, K A; Poulin, Y; Gooderham, M; Raman, M; Mallbris, L; Wang, C; Purohit, V; Mamolo, C; Papacharalambous, J; Ports, W C

2016-11-01

Despite unmet need, 15 years have passed since a topical therapy with a new mechanism of action for atopic dermatitis (AD) has been approved. Janus kinase (JAK) inhibitor treatment effect via topical application in patients with AD is unknown. Tofacitinib, a small-molecule JAK inhibitor, was investigated for the topical treatment of AD. In this 4-week, phase IIa, randomized, double-blind, vehicle-controlled study (NCT02001181), 69 adults with mild-to-moderate AD were randomized 1:1 to 2% tofacitinib or vehicle ointment twice daily. Percentage change from baseline (CFB) in Eczema Area and Severity Index (EASI) score at week 4 was the primary end point. Secondary efficacy end points included percentage CFB in body surface area (BSA), CFB in EASI Clinical Signs Severity Sum Score, proportion of patients with Physician's Global Assessment (PGA) response and CFB in patient-reported pruritus. Safety, local tolerability and pharmacokinetics were monitored. The mean percentage CFB at week 4 in EASI score was significantly greater (P tofacitinib (-81·7%) vs. vehicle (-29·9%). Patients treated with tofacitinib showed significant (P tofacitinib. Tofacitinib ointment showed significantly greater efficacy vs. vehicle across end points, with early onset of effect and comparable safety/local tolerability to vehicle. JAK inhibition through topical delivery is potentially a promising therapeutic target for AD. © 2016 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.

Some topics on safety analysis and accident nodalization of CAREM-25

International Nuclear Information System (INIS)

Gimenez, Marcelo O.; Zanocco, Pablo; Schlamp, Miguel A.; Ottaviani, Anahi; Garcia, Alicia

2000-01-01

The main goal of nuclear safety area in the CAREM Project Phase I, carried out during 1999, was to consolidate the safety systems design through an integral analysis of the reactor and the safety systems response to different accidental sequences. A primary circuit nodalization, including the steam generators, was done with RELAP5 code. The modeling of System 230 (absorber rods drive feed water system), System 1400 (purification and control volume system) and steam condensation on the absorber rods drive system and on RPV wall is implemented through boundary conditions. Also the Residual Heat Removal System and the Second Shutdown system are modeled. The reactor steady state at full power was calculated. The results agree quite well with design values. It can be said from the accident analysis that the nodalization responds properly. Further analysis should be done in order to qualify the nodalization and to compare benchmarks with other codes and experimental data. On the other hand, the steam dome model should be improved with more precise data about absorber rods drive system condensation, loss of heat and inner components layout. (author)

Student manual, Book 2: Orientation to occupational safety compliance in DOE

Energy Technology Data Exchange (ETDEWEB)

Colley, D.L.

1993-10-01

This is a student hand-book an Occupational Safety Compliance in DOE. Topics include the following: Electrical; materials handling & storage; inspection responsibilities & procedures; general environmental controls; confined space entry; lockout/tagout; office safety, ergonomics & human factors; medical & first aid, access to records; construction safety; injury/illness reporting system; and accident investigation procedures.

Program desk manual for occupational safety and health -- U.S. Department of Energy Richland Operations, Office of Environment Safety and Health

International Nuclear Information System (INIS)

Musen, L.G.

1998-01-01

The format of this manual is designed to make this valuable information easily accessible to the user as well as enjoyable to read. Each chapter contains common information such as Purpose, Scope, Policy and References, as well as information unique to the topic at hand. This manual can also be provided on a CD or Hanford Internet. Major topics include: Organization and program for operational safety; Occupational medicine; Construction and demolition; Material handling and storage; Hoisting and rigging; Explosives; Chemical hazards; Gas cylinders; Electrical; Boiler and pressure vessels; Industrial fire protection; Industrial hygiene; and Safety inspection checklist

Program desk manual for occupational safety and health -- U.S. Department of Energy Richland Operations, Office of Environment Safety and Health

Energy Technology Data Exchange (ETDEWEB)

Musen, L.G.

1998-08-27

The format of this manual is designed to make this valuable information easily accessible to the user as well as enjoyable to read. Each chapter contains common information such as Purpose, Scope, Policy and References, as well as information unique to the topic at hand. This manual can also be provided on a CD or Hanford Internet. Major topics include: Organization and program for operational safety; Occupational medicine; Construction and demolition; Material handling and storage; Hoisting and rigging; Explosives; Chemical hazards; Gas cylinders; Electrical; Boiler and pressure vessels; Industrial fire protection; Industrial hygiene; and Safety inspection checklist.

78 FR 48468 - Delphi Corporation, Electronics and Safety Division, Including On-Site Leased Workers From...

Science.gov (United States)

2013-08-08

..., Electronics and Safety Division, Including On-Site Leased Workers From Securitas, Bartech, Flint Janitorial... Adjustment Assistance on May 20, 2013, applicable to workers of Delphi Corporation, Electronics and Safety... on- site at the Flint, Michigan location of Delphi Corporation, Electronics and Safety Division. The...

Link between Research, Development and Demonstration (RD and D) and Stakeholder Confidence: the Specific Aspect of Long-term Safety. Proceedings of a Topical Session, Issy-les-Moulineaux, France 6-8 June 2007

International Nuclear Information System (INIS)

2008-01-01

The Forum on Stakeholder Confidence (FSC) was created under a mandate from the OECD Nuclear Energy Agency's Radioactive Waste Management Committee (RWMC) to facilitate the sharing of international experience in addressing the societal dimension of radioactive waste management. It explores means of ensuring an effective dialogue with the public, and considers ways to strengthen confidence in decision-making processes. NEA member countries nominate participants. The FSC today includes representatives of national regulators, implementing agencies, policy makers, and R and D scientists from 16 OECD countries and two international organisations. Each has experience in and/or responsibility for stakeholder interaction. The Forum was launched in August 2000, in Paris, and convenes a series of alternating regular meetings and workshops. The FSC is expected to identify specific issues of interest on which stakeholders can learn from one another and provide a platform for discussing and exchanging those issues. This topical session's emphasis on long-term safety is meant to complement the Programme of Work of the RWMC in this area and to create a bridge between the FSC and the more technically oriented groups of the RWMC, e.g., the Integration Group for the Safety Case (IGSC) and the Regulators' Forum. These Proceedings are meant to provide a record that can be used by a wide spectrum of stakeholders and decision-makers. They include: a) An executive summary of the topical presentations, and of the discussion they sparked within the FSC; b) Texts and Power Point presentations provided by the speakers at the Topical Session

Safety research in nuclear fuel cycle at PNC

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-09-01

This report collects the results of safety research in nuclear fuel cycle at Power Reactor and Nuclear Fuel Development Corporation, in order to answer to the Questionnaire of OECD/NEA. The Questionnaire request to include information concerning to research topic, description, main results (if available), reference documents, research institutes involved, sponsoring organization and other pertinent information about followings: a) Recently completed research projects. b) Ongoing (current) research projects. Achievements on following items are omitted by the request of OECD/NEA, uranium mining and milling, uranium refining and conversion to UF{sub 6}, uranium enrichment, fuel manufacturers, spent fuel storage, radioactive waste management, transport of radioactive materials, decommissioning. We select topics from the fields of a) nuclear installation, b) seismic, and c) PSA, in projects from frame of annual safety research plan for nuclear installations established by Nuclear Safety Commission. We apply for the above a) and b) projects as follows: a) Achievements in Safety Research, fiscal 1991-1995, b) fiscal 1996 Safety Research Achievements: Progress. (author)

Safety research in nuclear fuel cycle at PNC

International Nuclear Information System (INIS)

1998-09-01

This report collects the results of safety research in nuclear fuel cycle at Power Reactor and Nuclear Fuel Development Corporation, in order to answer to the Questionnaire of OECD/NEA. The Questionnaire request to include information concerning to research topic, description, main results (if available), reference documents, research institutes involved, sponsoring organization and other pertinent information about followings: a) Recently completed research projects. b) Ongoing (current) research projects. Achievements on following items are omitted by the request of OECD/NEA, uranium mining and milling, uranium refining and conversion to UF 6 , uranium enrichment, fuel manufacturers, spent fuel storage, radioactive waste management, transport of radioactive materials, decommissioning. We select topics from the fields of a) nuclear installation, b) seismic, and c) PSA, in projects from frame of annual safety research plan for nuclear installations established by Nuclear Safety Commission. We apply for the above a) and b) projects as follows: a) Achievements in Safety Research, fiscal 1991-1995, b) fiscal 1996 Safety Research Achievements: Progress. (author)

Topical immunomodulators in dermatology

Directory of Open Access Journals (Sweden)

Khandpur Sujay

2004-04-01

Full Text Available Topical immunomodulators are agents that regulate the local immune response of the skin. They are now emerging as the therapy of choice for several immune-mediated dermatoses such as atopic dermatitis, contact allergic dermatitis, alopecia areata, psoriasis, vitiligo, connective tissue disorders such as morphea and lupus erythematosus, disorders of keratinization and several benign and malignant skin tumours, because of their comparable efficacy, ease of application and greater safety than their systemic counterparts. They can be used on a domiciliary basis for longer periods without aggressive monitoring. In this article, we have discussed the mechanism of action, common indications and side-effects of the commonly used topical immunomodulators, excluding topical steroids. Moreover, newer agents, which are still in the experimental stages, have also been described. A MEDLINE search was undertaken using the key words "topical immunomodulators, dermatology" and related articles were also searched. In addition, a manual search for many Indian articles, which are not indexed, was also carried out. Wherever possible, the full article was reviewed. If the full article could not be traced, the abstract was used.

46{sup th} Annual meeting on nuclear technology (AMNT 2015). Key topic / Enhanced safety and operation excellence / Sustainable reactor operation management - safe, efficient, valuable

Energy Technology Data Exchange (ETDEWEB)

Fischer, Erwin [E.ON Kernkraft GmbH, Global Unit Next Generation, Hannover (Germany)

2015-08-15

Summary report on the following Topical Session of the 46{sup th} Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015: - Sustainable Reactor Operation Management - Safe, Efficient, Valuable (Erwin Fischer) The other Sessions of the Key Topics - ''Outstanding Know-How and Sustainable Innovations'', - ''Enhanced Safety and Operation Excellence'' and - ''Decommissioning Experience and Waste Management Solutions'' have been covered in atw 7 (2015) and will be covered in further issues of atw.

Objective and character of safety culture

International Nuclear Information System (INIS)

Aastrand, K.

2005-01-01

The main topics of the lecture include: (1) concepts of safety culture introduced in INSAG-4, (2) stages of development of safety culture, (3) general practises to develop organizational effectiveness as a means of implementing and improving safety culture, (4) specific practises to develop safety culture applying to all stages of a nuclear installation's life cycle, (5) suggestions on assessing the progress of development of safety culture in an organization and on evaluating the influence of major environmental and internal organizational factors on that culture, and (6) guidance on the detection of incipient weaknesses in safety culture that may be of particular interest to regulators and those responsible for self-assessment in organization

Contrast media. Safety issues and ESUR guidelines. 3. ed.

International Nuclear Information System (INIS)

Thomsen, Henrik S.; Webb, Judith A.W.

2014-01-01

Fully updates the previous edition and includes new chapters on various complex topics. Represents a unique and unparalleled source of information on the many safety issues relating to different contrast media. Includes chapters on acute and delayed non-renal adverse reactions and on renal adverse reactions. Presented in a handy, easy-to-use format. In 1994 the European Society of Urogenital Radiology (ESUR) set up a committee to consider the safety of contrast media used for diagnostic imaging. Subsequently the committee questioned ESUR members, reviewed the literature, proposed guidelines, and discussed these proposals with participants at the annual symposia of the society. The end result of this work was the successful first edition of this book, published in 2006, which was followed by an equally successful second edition in 2009. This third edition not only fully updates the previous edition, but also includes new chapters on complex topics such as use of contrast media in children and practical aspects of off-label contrast media use. The authorship includes members, past members, and non-members of the Contrast Media Safety Committee.

Proceedings of the 1992 topical meeting on advances in reactor physics

International Nuclear Information System (INIS)

1992-01-01

This document, Volume 1, presents proceedings of the 1992 Topical Meeting on Advances in Reactor Physics on March 8--11, 1992 at Charleston, SC. Session topics were as follows: Code Benchmarks and Validation; Fuel Management; Nodal Methods for Diffusion Theory; Criticality Safety and Applications and Waste; Core Computational Systems; Nuclear Data; Safety Aspects of Heavy Water Reactors; and Space-Time Core Kinetics. The individual papers have been cataloged separately. (FI)

The Markov Latent Effects Approach to Safety and Decision -Making; TOPICAL

International Nuclear Information System (INIS)

COOPER, J. ARLIN

2001-01-01

The methodology in this report addresses the safety effects of organizational and operational factors that can be measured through ''inspection.'' The investigation grew out of a preponderance of evidence that the safety ''culture'' (attitude of employees and management toward safety) was frequently one of the major root causes behind accidents or safety-relevant failures. The approach is called ''Markov latent effects'' analysis. Since safety also depends on a multitude of factors that are best measured through well known risk analysis methods (e.g., fault trees, event trees, FMECA, physical response modeling, etc.), the Markov latent effects approach supplements conventional safety assessment and decision analysis methods. A top-down mathematical approach is developed for decomposing systems, for determining the most appropriate items to be measured, and for expressing the measurements as imprecise subjective metrics through possibilistic or fuzzy numbers. A mathematical model is developed that facilitates combining (aggregating) inputs into overall metrics and decision aids, also portraying the inherent uncertainty. A major goal of the modeling is to help convey the top-down system perspective. Metrics are weighted according to significance of the attribute with respect to subsystems and are aggregated nonlinearly. Since the accumulating effect responds less and less to additional contribution, it is termed ''soft'' mathematical aggregation, which is analogous to how humans frequently make decisions. Dependence among the contributing factors is accounted for by incorporating subjective metrics on commonality and by reducing the overall contribution of these combinations to the overall aggregation. Decisions derived from the results are facilitated in several ways. First, information is provided on input ''Importance'' and ''Sensitivity'' (both Primary and Secondary) in order to know where to place emphasis on investigation of root causes and in considering new

Siting of nuclear facilities. Selections from Nuclear Safety

Energy Technology Data Exchange (ETDEWEB)

Buchanan, J.R.

1976-07-01

The report presented siting policy and practice for nuclear power plants as developed in the U.S. and abroad. Twenty-two articles from Nuclear Safety on this general topic are reprinted since they provide a valuable reference source. The appendices also include reprints of some relevant regulatory rules and guides on siting. Advantages and disadvantages of novel siting concepts such as underground containment, offshore siting, and nuclear energy parks are addressed. Other topics include site criteria, risk criteria, and nuclear ship criteria.

Siting of nuclear facilities. Selections from Nuclear Safety

International Nuclear Information System (INIS)

Buchanan, J.R.

1976-07-01

The report presented siting policy and practice for nuclear power plants as developed in the U.S. and abroad. Twenty-two articles from Nuclear Safety on this general topic are reprinted since they provide a valuable reference source. The appendices also include reprints of some relevant regulatory rules and guides on siting. Advantages and disadvantages of novel siting concepts such as underground containment, offshore siting, and nuclear energy parks are addressed. Other topics include site criteria, risk criteria, and nuclear ship criteria

Oversight and Influencing of Licensee Leadership and Management for Safety, Including Safety Culture - Regulatory Approaches and Methods. Proceedings of an NEA/IAEA Workshop, Chester, United Kingdom, 26-28 September 2011

International Nuclear Information System (INIS)

2012-01-01

Both regulators and the nuclear industry recognise the need for licensees to develop a strong, positive safety culture to support successful and sustainable nuclear safety performance. A number of reports have been issued by the IAEA and the NEA on the role of the regulator in relation to oversight of safety culture (References 1 to 5). There has been less clarity on how this should be achieved - in particular, with regard to strategies and practical approaches for maintaining oversight of, and influencing, those facets of licensee leadership and management which have a profound influence on safety culture. In recognition of this, the CSNI Working Group on Human and Organisational Factors (WGHOF), together with the CNRA Working Group on Inspection Practices (WGIP) and the IAEA, organised a workshop in Chester, United Kingdom, in May 2007 to provide a forum for gathering and sharing international experience, including good practices and learning points. The results of the workshop are reported in Reference 6. Workshop participants agreed that, in view of the rapidly developing approaches in this area, it would be sensible to hold a further workshop ('Chester 2') in 3-5 years in order to discuss how regulatory approaches have moved on and to share lessons learned from their application. In 2010, the WGIP hosted a workshop which included regulatory approaches for the assessment of licensee safety culture as a discussion topic. The outputs of the workshop included a list of commendable practices for monitoring and evaluating licensee safety culture (Reference 7). The 'Chester 2' workshop took place in September 2011. This report sets out the findings of the workshop, organised by the UK Office for Nuclear Regulation (ONR) on behalf of the CSNI/WGHOF and the IAEA. The workshop was attended by over 40 representatives of nuclear regulatory bodies and licensees from 15 countries plus IAEA and NEA. The workshop featured keynote papers on learning from major events, and from

Student manual, Book 2: Orientation to occupational safety compliance in DOE

International Nuclear Information System (INIS)

Colley, D.L.

1993-01-01

This is a student hand-book an Occupational Safety Compliance in DOE. Topics include the following: Electrical; materials handling ampersand storage; inspection responsibilities ampersand procedures; general environmental controls; confined space entry; lockout/tagout; office safety, ergonomics ampersand human factors; medical ampersand first aid, access to records; construction safety; injury/illness reporting system; and accident investigation procedures

Development of a British Road Safety Education Support Materials Curriculum.

Science.gov (United States)

Bouck, Linda H.

Road safety education needs to be a vital component in the school curriculum. This paper describes a planned road safety education support materials curriculum developed to aid educators in the Wiltshire County (England) primary schools. Teaching strategies include topic webs, lecture, class discussion, group activities, and investigative learning…

Freshman Health Topics

Science.gov (United States)

Hovde, Karen

2011-01-01

This article examines a cluster of health topics that are frequently selected by students in lower division classes. Topics address issues relating to addictive substances, including alcohol and tobacco, eating disorders, obesity, and dieting. Analysis of the topics examines their interrelationships and organization in the reference literature.…

Safety for all: The new INSAG

International Nuclear Information System (INIS)

Meserve, Richard; Brockman, Kenneth

2004-01-01

In 1985, the IAEA Director General identified the need for an advisory committee to the IAEA in the area of nuclear safety. The group that was subsequently chartered was called the International Nuclear Safety Advisory Group (INSAG). The nuclear community knew it over the years for the sage counsel and advice that it provided to, and through, the Agency. Between 1985 and 2002, INSAG membership ranged from 13 to 15 experts from around the world. Individuals whose names are synonymous with a commitment to nuclear safety led the group during these years. Over these 17 years, INSAG produced numerous studies that provided the foundation for advances in nuclear safety. These studies included evaluations of design and operational safety at nuclear power plants, consideration of the impacts of radiological exposures, and the examination of how best to develop and maintain a proper safety culture. While INSAG publications were recognized throughout the nuclear community as authoritative and insightful reflections on topics relating to nuclear safety, some believed the Group was limited by its charter obligation to provide advice solely to the IAEA. Other international groups of experts, most notably the International Commission on Radiological Protection (ICRP), evolved with much broader responsibilities. As result, the organization and Terms of Reference for the ICRP were seen to provide a model to emulate if one wanted to have an expert group that could serve all concerned stake holders. It was in response to this desire that the current INSAG was chartered. The IAEA has issued a collection of reports on nuclear safety under the INSAG framework. They include the world's fi rst authoritative account of the 1986 nuclear accident at Chernobyl, and an update issued in 1993. Other reports have focused on topics including basic safety principles; safety culture; regulatory decision-making; knowledge management; safe management of radioactive sources; and the defence

Special topics reports for the reference tandem mirror fusion breeder. Volume 2. Reactor safety assessment

International Nuclear Information System (INIS)

Maya, I.; Hoot, C.G.; Wong, C.P.C.; Schultz, K.R.; Garner, J.K.; Bradbury, S.J.; Steele, W.G.; Berwald, D.H.

1984-09-01

The safety features of the reference fission suppressed fusion breeder reactor are presented. These include redundancy and overcapacity in primary coolant system components to minimize failure probability, an improved valve location logic to provide for failed component isolation, and double-walled coolant piping and steel guard vessel protection to further limit the extent of any leak. In addition to the primary coolant and decay heat removal system, reactor safety systems also include an independent shield cooling system, the module safety/fuel transfer coolant system, an auxiliary first wall cooling system, a psssive dump tank cooling system based on the use of heat pipes, and several lithium fire suppression systems. Safety system specifications are justified based on the results of thermal analysis, event tree construction, consequence calculations, and risk analysis. The result is a reactor design concept with an acceptably low probability of a major radioactivity release. Dose consequences of maximum credible accidents appear to be below 10CFR100 regulatory limits

78 FR 49684 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-08-15

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Model Transformation for a System of Systems Dependability Safety Case

Science.gov (United States)

Murphy, Judy; Driskell, Steve

2011-01-01

The presentation reviews the dependability and safety effort of NASA's Independent Verification and Validation Facility. Topics include: safety engineering process, applications to non-space environment, Phase I overview, process creation, sample SRM artifact, Phase I end result, Phase II model transformation, fault management, and applying Phase II to individual projects.

78 FR 17099 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Science.gov (United States)

2013-03-20

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including...

78 FR 65874 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-11-04

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including...

77 FR 65478 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Science.gov (United States)

2012-10-29

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River...

77 FR 60044 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2012-10-02

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River...

Safety culture

International Nuclear Information System (INIS)

Keen, L.J.

2003-01-01

Safety culture has become a topic of increasing interest for industry and regulators as issues are raised on safety problems around the world. The keys to safety culture are organizational effectiveness, effective communications, organizational learning, and a culture that encourages the identification and resolution of safety issues. The necessity of a strong safety culture places an onus on all of us to continually question whether the safety measures already in place are sufficient, and are being applied. (author)

Summary record of the topical session of 12. Meeting of the IGSC

International Nuclear Information System (INIS)

Bailey, Lucy; Hunt, N.

2010-01-01

The objectives for this topical session were: - Explore issues of optimisation - what does it mean in practice? - Can we clarify the principles of optimisation? - To what extent is the process of optimisation more important than the end results? - Learn from experience in national programs; - Case studies from programs at different stages; - How have optimisation principles been applied in real program decisions? - How are optimisation arguments presented in safety cases? - Are there any optimisation issues that could benefit from further IGSC work? Key topics discussed in the opening remarks included: - Balance: this includes long-term safety versus near-term operational safety and the issue of safety versus cost; - Integration: this relates to how optimisation is implemented at different program stages, the implications of site selection (i.e., volunteer site versus 'best' site) and stakeholder acceptability; - Regulatory Perspective: this considers how different factors (such as dose, risk, cost, robustness, etc.) should be weighted and the optimisation arguments that regulators are expecting; - Process: the 'who', 'what' and 'when' of optimisation. Presentations from selected national programs provided case studies in optimisation for a range of situations: NEA: Optimisation of the System of Decommissioning Waste Production through Disposal; UK: NDA Approach on Upstream and Disposal System Optioneering; Germany: Methods to Support Comparison of Sites for Deep Geological Disposal of Radioactive Waste; France: Presentation on Optimisation in Siting Decisions; Finland: Comparison and Evaluation of KBS-3 Horizontal and Vertical Options; USA: Optimisation at WIPP Based on 11 Years of Operational Experience. Following the presentations, the floor was opened to discussion around the following topics: What are the key issues? Which would benefit from IGSC attention? What further work is warranted by the IGSC and on what time frame? The discussion was widely ranging and

Topics to be covered in safety analysis reports for nuclear power plants with pressurized water reactors or boiling water reactors in the F.R.G

International Nuclear Information System (INIS)

Kohler, H.A.G.

1977-01-01

This manual aims at defining the standards to be used in Safety Analysis Reports for Nuclear Power Plants with Pressurized Water Reactors or Boiling Water Reactors in the Federal Republic of Germany. The topics to be covered are: Information about the site (geographic situation, settlement, industrial and military facilities, transport and communications, meteorological conditions, geological, hydrological and seismic conditions, radiological background), description of the power plant (building structures, safety vessel, reactor core, cooling system, ventilation systems, steam power plant, electrical facilities, systems for measurement and control), indication of operation (commissioning, operation, safety measures, radiation monitoring, organization), incident analysis (reactivity incidents, loss-of-coolant incidents, external impacts). (HP) [de

Topical Session on Materials Management

International Nuclear Information System (INIS)

2002-01-01

At its second meeting, in Paris, 5-7 December 2001, the WPDD held two topical sessions on the D and D Safety Case and on the Management of Materials from D and D, respectively. This report documents the topical session on the management of materials. Presentations during the topical session covered key aspects of the management of materials and meant to provide an exchange of information and experience, including: Experience and lessons learnt from VLLW and non-radioactive material management in Spain and Germany with special attention to recycling (How specific solutions came about? Are there 'generic' examples for wider adoption?); Risk assessment of recycling and non-recycling: a CPD study; Waste acceptance issues within different national contexts (What constraints are there on the waste receiving body and what flexibility can the latter have? What constraints does this impose on D and D implementers? What about wastes are without current solution? What needs to be done? What about large items and 'difficult' waste in general?); Radiological characterisation of materials during decommissioning, particularly difficult situations - large volumes, large items,.. wastes, heterogeneous streams (What examples of established practice? What are the approaches or aspects that set the regulatory requirements? How can the flow rates be large but the answers acceptable? How much is needed to be known for later action, e. g., disposal, release, protection of worker, etc.); Radiological characterisation of buildings as they stand, in order to allow conventional demolition (What are strategies for optimisation of characterisation? How much needs to be known to take action later? e.g. for storage, disposal, release, cost estimation and ALARA? What needs to be done in advance and after decommissioning/dismantling?). At the end of each presentation time was allotted for discussion of the paper. Integral to the Topical Session was a facilitated plenary discussion on the topical

47{sup th} Annual conference on nuclear technology (AMNT 2016). Key topics / Outstanding know-how and sustainable innovations - enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Raetzke, Christian [CONLAR - Consulting on Nuclear Law, Licensing and Regulation, Leipzig (Germany); Fischer, Erwin [PreussenElektra GmbH, Hannover (Germany). Management Board; Mohrbach, Ludger [VGB PowerTech e.V., Essen (Germany). Competence Center ' ' Nuclear Power Plants' '

2016-08-15

Summary report on the Key Topics ''Outstanding Know-How and Sustainable Innovations'' and ''Enhanced Safety and Operation Excellence'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 will be covered in further issues of atw.

Tutorial on nuclear thermal propulsion safety for Mars

International Nuclear Information System (INIS)

Buden, D.

1992-01-01

Safety is the prime design requirement for nuclear thermal propulsion (NTP). It must be built in at the initiation of the design process. An understanding of safety concerns is fundamental to the development of nuclear rockets for manned missions to Mars and many other applications that will be enabled or greatly enhanced by the use of nuclear propulsion. To provide an understanding of the basic issues, a tutorial has been prepared. This tutorial covers a range of topics including safety requirements and approaches to meet these requirements, risk and safety analysis methodology, NERVA reliability and safety approach, and life cycle risk assessments

Mining FDA drug labels using an unsupervised learning technique--topic modeling.

Science.gov (United States)

Bisgin, Halil; Liu, Zhichao; Fang, Hong; Xu, Xiaowei; Tong, Weida

2011-10-18

The Food and Drug Administration (FDA) approved drug labels contain a broad array of information, ranging from adverse drug reactions (ADRs) to drug efficacy, risk-benefit consideration, and more. However, the labeling language used to describe these information is free text often containing ambiguous semantic descriptions, which poses a great challenge in retrieving useful information from the labeling text in a consistent and accurate fashion for comparative analysis across drugs. Consequently, this task has largely relied on the manual reading of the full text by experts, which is time consuming and labor intensive. In this study, a novel text mining method with unsupervised learning in nature, called topic modeling, was applied to the drug labeling with a goal of discovering "topics" that group drugs with similar safety concerns and/or therapeutic uses together. A total of 794 FDA-approved drug labels were used in this study. First, the three labeling sections (i.e., Boxed Warning, Warnings and Precautions, Adverse Reactions) of each drug label were processed by the Medical Dictionary for Regulatory Activities (MedDRA) to convert the free text of each label to the standard ADR terms. Next, the topic modeling approach with latent Dirichlet allocation (LDA) was applied to generate 100 topics, each associated with a set of drugs grouped together based on the probability analysis. Lastly, the efficacy of the topic modeling was evaluated based on known information about the therapeutic uses and safety data of drugs. The results demonstrate that drugs grouped by topics are associated with the same safety concerns and/or therapeutic uses with statistical significance (P<0.05). The identified topics have distinct context that can be directly linked to specific adverse events (e.g., liver injury or kidney injury) or therapeutic application (e.g., antiinfectives for systemic use). We were also able to identify potential adverse events that might arise from specific

Efficacy and safety of diclofenac sodium 2% topical solution for osteoarthritis of the knee: a randomized, double-blind, vehicle-controlled, 4 week study.

Science.gov (United States)

Wadsworth, L Tyler; Kent, Jeffrey D; Holt, Robert J

2016-01-01

Nonsteroidal anti-inflammatory drugs (NSAIDs) are standard therapy for osteoarthritis (OA). Topically applied NSAIDs reduce systemic exposure compared with oral NSAIDS, and European guidelines recommend their use. The NSAID diclofenac is available in a range of topical formulations. Diclofenac 1% gel and 1.5% four times daily and 2% twice daily (BID) solutions are approved to reduce pain from OA of the knee(s). The objective of this study was to investigate the efficacy and safety of diclofenac sodium 2% topical solution BID versus vehicle control solution for treating pain associated with OA of the knee. A phase II, 4 week, randomized, double-blind, parallel-group, two-arm, vehicle-controlled study compared pain relief with diclofenac sodium 2% topical solution versus control (vehicle only) in patients aged 40 to 85 years with radiographically confirmed primary OA of the knee. ClinicalTrials.gov identifier NCT01119898. The primary efficacy outcome was change from baseline to the final visit in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. Secondary outcomes included additional WOMAC subscales and patient global assessment of OA. Treatment-emergent adverse events (TEAEs), skin irritation, and vital signs were assessed and collected throughout the study. Of 260 patients randomized, 259 received ≥1 dose of study drug. Significantly greater reductions in least-squares mean (standard error) WOMAC pain scores were observed for diclofenac-treated (-4.4 [0.4]) versus vehicle-treated patients (-3.4 [0.4]) at the final visit (p = 0.040). The most commonly reported TEAEs were administration site conditions. The vehicle-treated group experienced slightly more TEAEs than the active treatment group (38.8% vs. 31.5%). No serious adverse events were reported. Administration of diclofenac sodium 2% topical solution BID resulted in significantly greater improvement in pain reduction in patients with OA of the knee versus vehicle

Regulatory cross-cutting topics for fuel cycle facilities.

Energy Technology Data Exchange (ETDEWEB)

Denman, Matthew R.; Brown, Jason; Goldmann, Andrew Scott; Louie, David

2013-10-01

This report overviews crosscutting regulatory topics for nuclear fuel cycle facilities for use in the Fuel Cycle Research & Development Nuclear Fuel Cycle Evaluation and Screening study. In particular, the regulatory infrastructure and analysis capability is assessed for the following topical areas: Fire Regulations (i.e., how applicable are current Nuclear Regulatory Commission (NRC) and/or International Atomic Energy Agency (IAEA) fire regulations to advance fuel cycle facilities) Consequence Assessment (i.e., how applicable are current radionuclide transportation tools to support risk-informed regulations and Level 2 and/or 3 PRA) While not addressed in detail, the following regulatory topic is also discussed: Integrated Security, Safeguard and Safety Requirement (i.e., how applicable are current Nuclear Regulatory Commission (NRC) regulations to future fuel cycle facilities which will likely be required to balance the sometimes conflicting Material Accountability, Security, and Safety requirements.)

Main technical topics in 1999

International Nuclear Information System (INIS)

2000-01-01

This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

Status of nuclear safety R ampersand D in the US

International Nuclear Information System (INIS)

Bari, R.A.

1993-01-01

The status of nuclear safety research and development in the US is presented with particular emphasis on work performed by Brookhaven National Laboratory. The nuclear safety program in the US encompasses safety of the current generation of operating commercial reactors, safety-related design of the next generation of advanced reactors, and safety activities for the reactors owned by the US Department of Energy. The broad topical areas of safety research include (but are not limited to) severe accidents, reliability/risk assessment, human performance, thermal-hydraulics, plant aging, seismic, and structural studies

Relationships between road safety, safety measures and external factors : a scan of the literature in view of model development and topics for further research.

NARCIS (Netherlands)

Churchill, T. & Norden, Y. van

2010-01-01

The purpose of this literature scan is to examine where literature on the effect of external factors and road safety measures on road safety exists and where it is lacking. This scan will help us to decide which factors to include in a comprehensive road safety model as SWOV is working on, and at

Technical safety requirements control level verification; TOPICAL

International Nuclear Information System (INIS)

STEWART, J.L.

1999-01-01

A Technical Safety Requirement (TSR) control level verification process was developed for the Tank Waste Remediation System (TWRS) TSRs at the Hanford Site in Richland, WA, at the direction of the US. Department of Energy, Richland Operations Office (RL). The objective of the effort was to develop a process to ensure that the TWRS TSR controls are designated and managed at the appropriate levels as Safety Limits (SLs), Limiting Control Settings (LCSs), Limiting Conditions for Operation (LCOs), Administrative Controls (ACs), or Design Features. The TSR control level verification process was developed and implemented by a team of contractor personnel with the participation of Fluor Daniel Hanford, Inc. (FDH), the Project Hanford Management Contract (PHMC) integrating contractor, and RL representatives. The team was composed of individuals with the following experience base: nuclear safety analysis; licensing; nuclear industry and DOE-complex TSR preparation/review experience; tank farm operations; FDH policy and compliance; and RL-TWRS oversight. Each TSR control level designation was completed utilizing TSR control logic diagrams and TSR criteria checklists based on DOE Orders, Standards, Contractor TSR policy, and other guidance. The control logic diagrams and criteria checklists were reviewed and modified by team members during team meetings. The TSR control level verification process was used to systematically evaluate 12 LCOs, 22 AC programs, and approximately 100 program key elements identified in the TWRS TSR document. The verification of each TSR control required a team consensus. Based on the results of the process, refinements were identified and the TWRS TSRs were modified as appropriate. A final report documenting key assumptions and the control level designation for each TSR control was prepared and is maintained on file for future reference. The results of the process were used as a reference in the RL review of the final TWRS TSRs and control suite. RL

Model for safety reports including descriptive examples; Mall foer saekerhetsrapporter med beskrivande exempel

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-01

Several safety reports will be produced in the process of planning and constructing the system for disposal of high-level radioactive waste in Sweden. The present report gives a model, with detailed examples, of how these reports should be organized and what steps they should include. In the near future safety reports will deal with the encapsulation plant and the repository. Later reports will treat operation of the handling systems and the repository.

Upgraded safety analysis document including operations policies, operational safety limits and policy changes. Revision 2

International Nuclear Information System (INIS)

Batchelor, K.

1996-03-01

The National Synchrotron Light Source Safety Analysis Reports (1), (2), (3), BNL reports number-sign 51584, number-sign 52205 and number-sign 52205 (addendum) describe the basic Environmental Safety and Health issues associated with the department's operations. They include the operating envelope for the Storage Rings and also the rest of the facility. These documents contain the operational limits as perceived prior or during construction of the facility, much of which still are appropriate for current operations. However, as the machine has matured, the experimental program has grown in size, requiring more supervision in that area. Also, machine studies have either verified or modified knowledge of beam loss modes and/or radiation loss patterns around the facility. This document is written to allow for these changes in procedure or standards resulting from their current mode of operation and shall be used in conjunction with the above reports. These changes have been reviewed by NSLS and BNL ES and H committee and approved by BNL management

EC6 safety enhancement - including impact of Fukushima lessons learned

Energy Technology Data Exchange (ETDEWEB)

Yu, S.; Zemdegs, R.; Boyle, S.; Soulard, M., E-mail: stephen.yu@candu.com [Candu Energy Inc., Mississauga, Ontario (Canada)

2012-09-15

The Enhanced CANDU 6 (EC6) is the new Generation III CANDU reactor design that meets the most up to date regulatory requirements and customer expectations. EC6 builds on the proven high performance design inch as the Qinshan CANDU 6 units and has made improvements to safety and operational performance, and has incorporated extensive operational feedback including Fukushima. The Fukushima Dai-ichi March 11, 2011 event has demonstrated the importance of defence-in-depth considerations for beyond-design basis events, including severe accidents. The EC6 design is based on the defence-in-depth principles and provides further design features that address the lessons learned from Fukushima. (author)

Safety and Security Interface Technology Initiative

International Nuclear Information System (INIS)

Dr. Michael A. Lehto; Kevin J. Carroll; Dr. Robert Lowrie

2007-01-01

Earlier this year, the Energy Facility Contractors Group (EFCOG) was asked to assist in developing options related to acceleration deployment of new security-related technologies to assist meeting design base threat (DBT) needs while also addressing the requirements of 10 CFR 830. NNSA NA-70, one of the working group participants, designated this effort the Safety and Security Interface Technology Initiative (SSIT). Relationship to Workshop Theme. ''Supporting Excellence in Operations Through Safety Analysis'', (workshop theme) includes security and safety personnel working together to ensure effective and efficient operations. One of the specific workshop elements listed in the call for papers is ''Safeguards/Security Integration with Safety''. This paper speaks directly to this theme. Description of Work. The EFCOG Safety Analysis Working Group (SAWG) and the EFCOG Security Working Group formed a core team to develop an integrated process involving both safety basis and security needs allowing achievement of the DBT objectives while ensuring safety is appropriately considered. This effort garnered significant interest, starting with a two day breakout session of 30 experts at the 2006 Safety Basis Workshop. A core team was formed, and a series of meetings were held to develop that process, including safety and security professionals, both contractor and federal personnel. A pilot exercise held at Idaho National Laboratory (INL) in mid-July 2006 was conducted as a feasibility of concept review. Work Results. The SSIT efforts resulted in a topical report transmitted from EFCOG to DOE/NNSA in August 2006. Elements of the report included: Drivers and Endstate, Control Selections Alternative Analysis Process, Terminology Crosswalk, Safety Basis/Security Documentation Integration, Configuration Control, and development of a shared ''tool box'' of information/successes. Specific Benefits. The expectation or end state resulting from the topical report and associated

Topical anti-infective sinonasal irrigations: update and literature review.

Science.gov (United States)

Lee, Jivianne T; Chiu, Alexander G

2014-01-01

Sinonasal anti-infective irrigations have emerged as a promising therapeutic modality in the comprehensive management of chronic rhinosinusitis (CRS), particularly in the context of recalcitrant disease. The purpose of this article was to delineate the current spectrum of topical anti-infective therapies available and evaluate their role in the treatment of CRS. A systematic literature review was performed on all studies investigating the use of topical antimicrobial solutions in the medical therapy of CRS. Anti-infective irrigations were stratified into topical antibacterial, antifungal, and additive preparations according to their composition and respective microbicidal properties. The use of topical antibiotic irrigations has been supported by low-level studies in the treatment of refractory CRS, with optimal results achieved in patients who have undergone prior functional endoscopic sinus surgery and received culture-directed therapy. Multiple evidence-based reviews have not established any clinical benefit with the administration of topical antifungals, and their use is not currently recommended in the management of routine CRS. Topical additives including surfactants may be beneficial as adjunctive treatment for recalcitrant CRS, but additional research is needed to investigate their efficacy in comparison with other agents and establish safety profiles. Topical anti-infective solutions are not recommended as first-line therapy for routine CRS but may be considered as a potential option for patients with refractory CRS who have failed traditional medical and surgical intervention. Additional research is necessary to determine which patient populations would derive the most benefit from each respective irrigation regimen and identify potential toxicities associated with prolonged use.

Integrating Occupational Health and Safety into TAFE Courses: Curriculum Topics.

Science.gov (United States)

Hall, Bob; Mageean, Pauline

This guide is designed to help technical and further education (TAFE) curriculum writers in Australia integrate safety education into vocational education courses. It provides a general overview of occupational health and safety from the perspective of TAFE trade training and a brief summary of the major health and safety issues that might be…

Modelling of safety barriers including human and organisational factors to improve process safety

DEFF Research Database (Denmark)

Markert, Frank; Duijm, Nijs Jan; Thommesen, Jacob

2013-01-01

It is believed that traditional safety management needs to be improved on the aspect of preparedness for coping with expected and unexpected deviations, avoiding an overly optimistic reliance on safety systems. Remembering recent major accidents, such as the Deep Water Horizon, the Texas City....... A valuable approach is the inclusion of human and organisational factors into the simulation of the reliability of the technical system using event trees and fault trees and the concept of safety barriers. This has been demonstrated e.g. in the former European research project ARAMIS (Accidental Risk...

76 FR 35106 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2011-06-16

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago..., DHS. ACTION: Final rule. SUMMARY: The Coast Guard is establishing a permanent safety zone from Brandon... Safety Zones; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary...

The Efficacy and Safety of Topical Rocuronium Bromide to Induce Bilateral Mydriasis in Hispaniolan Amazon Parrots ( Amazona ventralis ).

Science.gov (United States)

Baine, Katherine; Hendrix, Diane V H; Kuhn, Sonia E; Souza, Marcy J; Jones, Michael P

2016-03-01

The efficacy and safety of topically applied rocuronium in Hispaniolan Amazon parrots ( Amazona ventralis ) was assessed in a group of 10 adult birds. A complete ophthalmic examination (including Schirmer tear test, ocular reflexes, applanation tonometry, fluorescein staining, and slit-lamp biomicroscopy) was performed, and rocuronium bromide (0.15 mg in both eyes) was administered. Pupillary light reflex (PLR) and pupillary diameter were recorded in a darkened room at the following time points: 0, 10, 20, 30, 40, 50, 60, 80, 100, 120, 140, 160, 180, 200, 220, 240, 300, and 360 minutes, and 24 hours. Fluorescein staining in both eyes was performed at 24 hours. By 10 minutes, PLR was absent in all birds (at 5 minutes, 8 birds; at 10 minutes, remaining 2 birds). Pupil diameter differed significantly from baseline at all time points. Additionally, PLR was decreased in 7/10 birds at 360 minutes and normal in all birds at 24 hours. Superficial corneal ulceration was observed at 24 hours in the left eye of 2/10 of the birds after fluorescein stain application. This study demonstrated that rocuronium bromide was an effective mydriatic agent in Hispaniolan Amazon parrots with rapid onset and prolonged duration of action.

Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study.

Science.gov (United States)

Ralph, David J; Eardley, Ian; Taubel, Jorg; Terrill, Paul; Holland, Tim

2018-02-01

over placebo. The most commonly reported adverse events during MED2005 treatment were headache (patients, n = 18 [7.9%]; partners, n = 3 [1.3%]) and nasopharyngitis (patients, n = 13 [5.7%]; partners, n = 2 [0.9%]). These findings suggest that topical glyceryl trinitrate could be a useful treatment option in ED. Strengths of this study include the use of a validated outcome measure. Limitations include the use of only 1 dosage. Further studies are warranted to investigate the efficacy of topical glyceryl trinitrate to include higher doses, thereby improving clinical significance, especially in cases of moderate and severe ED. Ralph DJ, Eardley I, Taubel J, et al. Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study. J Sex Med 2018;15:167-175. Copyright © 2017 Futura Medical. Published by Elsevier Inc. All rights reserved.

Mining FDA drug labels using an unsupervised learning technique - topic modeling

Science.gov (United States)

2011-01-01

Background The Food and Drug Administration (FDA) approved drug labels contain a broad array of information, ranging from adverse drug reactions (ADRs) to drug efficacy, risk-benefit consideration, and more. However, the labeling language used to describe these information is free text often containing ambiguous semantic descriptions, which poses a great challenge in retrieving useful information from the labeling text in a consistent and accurate fashion for comparative analysis across drugs. Consequently, this task has largely relied on the manual reading of the full text by experts, which is time consuming and labor intensive. Method In this study, a novel text mining method with unsupervised learning in nature, called topic modeling, was applied to the drug labeling with a goal of discovering “topics” that group drugs with similar safety concerns and/or therapeutic uses together. A total of 794 FDA-approved drug labels were used in this study. First, the three labeling sections (i.e., Boxed Warning, Warnings and Precautions, Adverse Reactions) of each drug label were processed by the Medical Dictionary for Regulatory Activities (MedDRA) to convert the free text of each label to the standard ADR terms. Next, the topic modeling approach with latent Dirichlet allocation (LDA) was applied to generate 100 topics, each associated with a set of drugs grouped together based on the probability analysis. Lastly, the efficacy of the topic modeling was evaluated based on known information about the therapeutic uses and safety data of drugs. Results The results demonstrate that drugs grouped by topics are associated with the same safety concerns and/or therapeutic uses with statistical significance (P<0.05). The identified topics have distinct context that can be directly linked to specific adverse events (e.g., liver injury or kidney injury) or therapeutic application (e.g., antiinfectives for systemic use). We were also able to identify potential adverse events that

78 FR 4071 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-01-18

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

Proceedings of the Topical Session on Applying Decommissioning Experience to the Design and Operation of New Nuclear Power Plants. Topical Session of the 9. Meeting of the WPDD Held in Senec, Slovak Republic 12-13 November 2008

International Nuclear Information System (INIS)

Noviello, Luigi; O'Sullivan, Patrick; Laurent, Gerard; Tuomisto, Harri; Metcalfe, Doug; Duncan, Allan

2009-01-01

At its ninth meeting, the WPDD held a topical session on Applying Decommissioning Experience to the Design and Operation of New Plants. In preparation for this, a survey was issued to reactor design organisations, electricity producers and safety authorities and responses were compiled into a summary report that provided a basis for discussion at the topical session. This report is in two parts: Part A documents the topical session, summarising the main points from the presentations and discussions and including the rapporteurs' reports. Part B provides a summary compilation of the responses received to the survey undertaken prior to the topical session. The topical session facilitated an exchange of information and experience between policy makers, regulators, electricity producers, design organisations and decommissioners on approaches and experiences to taking account of decommissioning considerations in the design of third generation reactor systems

Topics raised by the summary report of the first review meeting

International Nuclear Information System (INIS)

2001-01-01

This document presents the fulfilling of the Brazilian obligations under the Convention on Nuclear Safety. The Chapter 7 of the document contains topics raised by the summary report of the first review meeting. The chapter covers status and position of the regulatory body, collective doses, effluents release trends, adoption of the ICRP 60 and basic safety standards, regulatory strategy, quality assurance, monitoring safety management, international cooperation, probabilistic safety assessment and safety improvement programmes

Topical ganciclovir in the treatment of acute herpetic keratitis.

Science.gov (United States)

Tabbara, Khalid F; Al Balushi, Noorjehan

2010-08-19

Herpetic keratitis is caused by herpes simplex virus (HSV) and is a common cause of corneal blindness. Following a primary ocular herpetic infection, latency of the virus occurs, followed by subsequent recurrences of herpetic keratitis. Such recurrences may lead to structural damage of the cornea. Recurrent herpetic keratitis is a common indication for corneal transplantation. Recurrences of herpetic keratitis in the corneal graft may lead to corneal graft rejection. Several antiviral agents for HSV are available, including the thymidine analogs. Prolonged use of thymidine analogs may lead to toxicity of the ocular surface, including epithelial keratitis, corneal ulcers, follicular conjunctivitis, and punctal occlusions. Availability of topical antiviral agents that are safe and effective in the treatment and prophylaxis of herpetic keratitis is highly desirable. Ganciclovir is a potent inhibitor of members of the herpes virus family. The drug has been used systemically for the treatment of cytomegalovirus (CMV) retinitis. Its hematologic toxicity secondary to systemic administration led to its limited use in herpetic infections. On the other hand, topical ganciclovir has been shown to be as safe and effective as acyclovir in the treatment of herpetic epithelial keratitis. Furthermore, topical ganciclovir can reach therapeutic levels in the cornea and aqueous humor following topical application. Several clinical trials have shown that topical ganciclovir 0.15% ophthalmic gel is safe and effective in the treatment and prophylaxis of herpetic epithelial disease. Long-term use of ganciclovir ophthalmic gel in patients with penetrating keratoplasty following herpetic keratitis has prevented recurrences of the disease. Topical ganciclovir ophthalmic gel is well tolerated, does not cause toxic effects on the ocular surface, and does not cause hematologic abnormalities. Clinical studies have underscored the potential role of ganciclovir ophthalmic gel in the treatment and

Proceedings of the international symposium on research reactor safety operations and modifications

International Nuclear Information System (INIS)

1990-03-01

The International Symposium on Research Reactor Safety, Operations and Modifications was organized by the International Atomic Energy Agency in cooperation with Atomic Energy of Canada Limited-Research Company. The main objectives of this Symposium were: (1) to exchange information and to discuss current perspectives and concerns relating to all aspects to research reactor safety, operations, and modifications; and, (2) to present views and to discuss future initiatives and directions for research reactor design, operations, utilization, and safety. The symposium topics included: research reactor programmes and experience; research reactor design safety and analysis; research reactor modifications and decommissioning; research reactor licensing; and new research reactors. These topics were covered during eight oral sessions and three poster sessions. These Proceedings include the full text of the 93 papers presented. The subject of Symposium was quite wide-ranging in that it covered essentially all aspects of research reactor safety, operations, and modifications. This was considered to be appropriate and timely given the 326 research reactors currently in operation in some 56 countries; given the degree of their utilization which ranges from pure and applied research to radioisotopes production to basic training and manpower development; and given that many of these reactors are undergoing extensive modifications, core conversions, power upratings, and are becoming the subject of safety reassessment and regulatory reviews. Although the Symposium covered many topics, the majority of papers and discussions tended to focus mainly on research reactor safety. This was seen as a clear sign of the continuing recognition of the fundamental importance of identifying and addressing, particularly through international cooperation, issues and concerns associated with research reactor safety

Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 1

Energy Technology Data Exchange (ETDEWEB)

None

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS{reg_sign}) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS{reg_sign} DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS{reg_sign} Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport.

EM Health and Safety Plan Guidelines

Energy Technology Data Exchange (ETDEWEB)

1994-12-01

This document contains information about the Health and Safety Plan Guidelines. Topics discussed include: Regulatory framework; key personnel; hazard assessment; training requirements; personal protective equipment; extreme temperature disorders or conditions; medical surveillance; exposure monitoring/air sampling; site control; decontamination; emergency response/contingency plan; emergency action plan; confined space entry; and spill containment.

Probabilistic safety analyses. Status and further development of methods and models, applications

International Nuclear Information System (INIS)

Berg, H.P.; Schott, H.

1992-12-01

The report describes the topics of the deterministic and probabilistic approach. The PSA is used in order to investigate event sequences beyond design limits; in particular the expected frequency of core melting is important. The basis of PSA is described including its limits. Moreover, the current state of the art of science and technology in the field of PSA including the so-called 'living PSA' are explained. Some measures which result in order to improve the safety of a nuclear power plant from the German Risk-Study are shown. An overview is given on the status of PSA in periodic safety reviews in German nuclear power plants. Moreover, the main topics of running investigations are presented. (orig.) [de

Advanced research workshop: nuclear materials safety

International Nuclear Information System (INIS)

Jardine, L J; Moshkov, M M.

1999-01-01

The Advanced Research Workshop (ARW) on Nuclear Materials Safety held June 8-10, 1998, in St. Petersburg, Russia, was attended by 27 Russian experts from 14 different Russian organizations, seven European experts from six different organizations, and 14 U.S. experts from seven different organizations. The ARW was conducted at the State Education Center (SEC), a former Minatom nuclear training center in St. Petersburg. Thirty-three technical presentations were made using simultaneous translations. These presentations are reprinted in this volume as a formal ARW Proceedings in the NATO Science Series. The representative technical papers contained here cover nuclear material safety topics on the storage and disposition of excess plutonium and high enriched uranium (HEU) fissile materials, including vitrification, mixed oxide (MOX) fuel fabrication, plutonium ceramics, reprocessing, geologic disposal, transportation, and Russian regulatory processes. This ARW completed discussions by experts of the nuclear materials safety topics that were not covered in the previous, companion ARW on Nuclear Materials Safety held in Amarillo, Texas, in March 1997. These two workshops, when viewed together as a set, have addressed most nuclear material aspects of the storage and disposition operations required for excess HEU and plutonium. As a result, specific experts in nuclear materials safety have been identified, know each other from their participation in t he two ARW interactions, and have developed a partial consensus and dialogue on the most urgent nuclear materials safety topics to be addressed in a formal bilateral program on t he subject. A strong basis now exists for maintaining and developing a continuing dialogue between Russian, European, and U.S. experts in nuclear materials safety that will improve the safety of future nuclear materials operations in all the countries involved because of t he positive synergistic effects of focusing these diverse backgrounds of

Overview of the Nuclear Regulatory Commission's safety research program

International Nuclear Information System (INIS)

Beckjord, E.S.

1989-01-01

Accomplishments during 1988 of the Office of Nuclear Regulatory Research and the program of safety research are highlighted, and plans, expections, and needs of the next year and beyond are discussed. Topics discussed include: ECCS Appendix K Revision; pressurized thermal shock; NUREG-1150, or the PRA method performance document; resolution of station blackout; severe accident integration plan; nuclear safety research review committee; and program management

TU-EF-BRD-01: Topics in Quality and Safety Research and Level of Evidence

Energy Technology Data Exchange (ETDEWEB)

Pawlicki, T. [UCSD Medical Center (United States)

2015-06-15

Research related to quality and safety has been a staple of medical physics academic activities for a long time. From very early on, medical physicists have developed new radiation measurement equipment and analysis techniques, created ever increasingly accurate dose calculation models, and have vastly improved imaging, planning, and delivery techniques. These and other areas of interest have improved the quality and safety of radiotherapy for our patients. With the advent of TG-100, quality and safety is an area that will garner even more research interest in the future. As medical physicists pursue quality and safety research in greater numbers, it is worthwhile to consider what actually constitutes research on quality and safety. For example, should the development of algorithms for real-time EPID-based in-vivo dosimetry be defined as “quality and safety” research? How about the clinical implementation of such as system? Surely the application of failure modes and effects analysis to a clinical process would be considered quality and safety research, but is this type of research that should be included in the medical physics peer-reviewed literature? The answers to such questions are of critical importance to set researchers in a direction that will provide the greatest benefit to our field and the patients we serve. The purpose of this symposium is to consider what constitutes research in the arena of quality and safety and differentiate it from other research directions. The key distinction here is developing the tool itself (e.g. algorithms for EPID dosimetry) vs. studying the impact of the tool with some quantitative metric. Only the latter would I call quality and safety research. Issues of ‘basic’ versus ‘applied’ quality and safety research will be covered as well as how the research results should be structured to provide increasing levels of support that a quality and safety intervention is effective and sustainable. Examples from existing

47{sup th} Annual meeting on nuclear technology (AMNT 2016). Key Topics / Enhanced safety and operation excellence and decommissioning experience and Waste management solutions

Energy Technology Data Exchange (ETDEWEB)

Salnikova, Tatiana [AREVA GmbH, Erlangen (Germany); Schaffrath, Andreas [Gesellschaft fuer Anlagen- und Reaktorsicherheit (GRS) gGmbH, Garching (Germany)

2016-10-15

Summary report on the Key Topics ''Enhanced Safety and Operation Excellence'' and ''Decommissioning Experience and Waste Management Solutions'' of the 47{sup th} Annual Conference on Nuclear Technology (AMNT 2016) held in Hamburg, 10 to 12 May 2016. Other Sessions of AMNT 2016 have been and will be covered in further issues of atw.

Nuclear medicine software: safety aspects

International Nuclear Information System (INIS)

Anon.

1989-01-01

A brief editorial discusses the safety aspects of nuclear medicine software. Topics covered include some specific features which should be incorporated into a well-written piece of software, some specific points regarding software testing and legal liability if inappropriate medical treatment was initiated as a result of information derived from a piece of clinical apparatus incorporating a malfunctioning computer program. (U.K.)

Safety of nuclear power plants: Design. Safety requirements

International Nuclear Information System (INIS)

2000-01-01

The present publication supersedes the Code on the Safety of Nuclear Power Plants: Design (Safety Series No. 50-C-D (Rev. 1), issued in 1988). It takes account of developments relating to the safety of nuclear power plants since the Code on Design was last revised. These developments include the issuing of the Safety Fundamentals publication, The Safety of Nuclear Installations, and the present revision of various safety standards and other publications relating to safety. Requirements for nuclear safety are intended to ensure adequate protection of site personnel, the public and the environment from the effects of ionizing radiation arising from nuclear power plants. It is recognized that technology and scientific knowledge advance, and nuclear safety and what is considered adequate protection are not static entities. Safety requirements change with these developments and this publication reflects the present consensus. This Safety Requirements publication takes account of the developments in safety requirements by, for example, including the consideration of severe accidents in the design process. Other topics that have been given more detailed attention include management of safety, design management, plant ageing and wearing out effects, computer based safety systems, external and internal hazards, human factors, feedback of operational experience, and safety assessment and verification. This publication establishes safety requirements that define the elements necessary to ensure nuclear safety. These requirements are applicable to safety functions and the associated structures, systems and components, as well as to procedures important to safety in nuclear power plants. It is expected that this publication will be used primarily for land based stationary nuclear power plants with water cooled reactors designed for electricity generation or for other heat production applications (such as district heating or desalination). It is recognized that in the case of

Safety of nuclear power plants: Design. Safety requirements

International Nuclear Information System (INIS)

2004-01-01

The present publication supersedes the Code on the Safety of Nuclear Power Plants: Design (Safety Series No. 50-C-D (Rev. 1), issued in 1988). It takes account of developments relating to the safety of nuclear power plants since the Code on Design was last revised. These developments include the issuing of the Safety Fundamentals publication, The Safety of Nuclear Installations, and the present revision of various safety standards and other publications relating to safety. Requirements for nuclear safety are intended to ensure adequate protection of site personnel, the public and the environment from the effects of ionizing radiation arising from nuclear power plants. It is recognized that technology and scientific knowledge advance, and nuclear safety and what is considered adequate protection are not static entities. Safety requirements change with these developments and this publication reflects the present consensus. This Safety Requirements publication takes account of the developments in safety requirements by, for example, including the consideration of severe accidents in the design process. Other topics that have been given more detailed attention include management of safety, design management, plant ageing and wearing out effects, computer based safety systems, external and internal hazards, human factors, feedback of operational experience, and safety assessment and verification. This publication establishes safety requirements that define the elements necessary to ensure nuclear safety. These requirements are applicable to safety functions and the associated structures, systems and components, as well as to procedures important to safety in nuclear power plants. It is expected that this publication will be used primarily for land based stationary nuclear power plants with water cooled reactors designed for electricity generation or for other heat production applications (such as district heating or desalination). It is recognized that in the case of

Topical diclofenac in the treatment of osteoarthritis of the knee

Directory of Open Access Journals (Sweden)

Niklas Schuelert

2011-02-01

Full Text Available Niklas Schuelert, Fiona A Russell, Jason J McDougallDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaAbstract: Osteoarthritis (OA is a common disease that affects millions of people worldwide. As there is no cure for OA, drug treatment to relieve symptoms is the main form of management. Nonsteroidal anti-inflammatory drugs (NSAIDs such as diclofenac are the most commonly used drugs to treat knee OA pain. Unfortunately, these agents are associated with gastrointestinal and cardiovascular risks, which limit their chronic use. Topical NSAIDs are emerging as a viable alternative for managing OA pain. Because a pharmacologically effective dose can be restricted to the site of pain, there is superfluous systemic absorption, and the risk of related adverse effects is minimized. This article reviews the currently available preclinical and clinical information on topical diclofenac for the treatment of OA pain, including data from recently published randomized controlled trials regarding the efficacy and safety of topical diclofenac. Most studies confirm topical diclofenac to be as effective as oral diclofenac with significantly reduced side effects; however, the efficacy of NSAIDs is far from optimal, and more research needs to be done to investigate the underlying mechanisms of OA in order to improve treatment options, especially for patients with NSAID-resistant OA pain.Keywords: osteoarthritis, topical diclofenac, NSAID, joint pain 

Proceedings of first SWCR-KURRI academic seminar on research reactors and related research topics

International Nuclear Information System (INIS)

Kimura, Itsuro; Cong, Zhebao

1986-01-01

These are the proceedings of an academic seminar on research reactors and related research topics held at the Southwest Centre for Reactor Engineering Research and Design in Chengdu, Sichuan, People's Republic of China in September 24-26 in 1985. Included are the chairmen's addresses and 10 papers presented at the seminar in English. The titles of these papers are: (1) Nuclear Safety and Safeguards, (2) General Review of Thorium Research in Japanese Universities, (3) Comprehensive Utilization and Economic Analysis of the High Flux Engineering Test Reactor, (4) Present States of Applied Health Physics in Japan, (5) Neutron Radiography with Kyoto University Reactor, (6) Topics of Experimental Works with Kyoto University Reactor, (7) Integral Check of Nuclear Data for Reactor Structural Materials, (8) The Reactor Core, Physical Experiments and the Operation Safety Regulation of the Zero Energy Thermal Reactor for PWR Nuclear Power Plant, (9) HFETR Core Physical Parameters at Power, (10) Physical Consideration for Loads of Operated Ten Cycles in HFETR. (author)

Program nuclear safety research: report 2000

International Nuclear Information System (INIS)

Muehl, B.

2001-09-01

The reactor safety R and D work of forschungszentrum karlsruhe (FZK) had been part of the nuclear safety research project (PSF) since 1990. In 2000, a new organisational structure was introduced and the Nuclear Safety Research Project was transferred into the nuclear safety research programme (NUKLEAR). In addition to the three traditional main topics - Light Water Reactor safety, Innovative systems, Studies related to the transmutation of actinides -, the new Programme NUKLEAR also covers Safety research related to final waste storage and Immobilisation of HAW. These new topics, however, will only be dealt with in the next annual report. Some tasks related to the traditional topics have been concluded and do no longer appear in the annual report; other tasks are new and are described for the first time. Numerous institutes of the research centre contribute to the work programme, as well as several external partners. The tasks are coordinated in agreement with internal and external working groups. The contributions to this report, which are either written in German or in English, correspond to the status of early/mid 2001. (orig.)

Leadership and safety culture. Leadership for safety

International Nuclear Information System (INIS)

Fischer, Erwin; Nithack, Eckhard

2016-01-01

The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

Leadership and safety culture. Leadership for safety

Energy Technology Data Exchange (ETDEWEB)

Fischer, Erwin; Nithack, Eckhard [PreussenElektra GmbH, Hannover (Germany)

2016-08-15

The meaning of leadership for safety in the nuclear industry is pointed out. This topic has became an increasing rank since the German ''Energiewende''. Despite the phase-out of the German NPP's nuclear safety and the belonging safety culture needs to be well maintained. A challenge for the whole organisation. Following the challenge to operate nuclear power plants towards Operational Excellence a highly skilled and motivated organisation is needed. Therefore Leadership is a valuable success factor.

Efficacy and safety of topical application of 15% and 10% potassium hydroxide for the treatment of Molluscum contagiosum.

Science.gov (United States)

Teixidó, Concepció; Díez, Olga; Marsal, Josep R; Giner-Soriano, Maria; Pera, Helena; Martinez, Mireia; Galindo-Ortego, Gisela; Schoenenberger, Joan A; Real, Jordi; Cruz, Ines; Morros, Rosa

2018-02-26

Molluscum contagiosum is the most common skin infection in children. One topical treatment used for Molluscum contagiosum is potassium hydroxide. The objective of this study was to compare the efficacy of potassium hydroxide topical treatment at different concentrations with that of placebo in terms of complete clearing of Molluscum contagiosum lesions and to assess the safety and tolerance of potassium hydroxide topical treatment. This was a double-blind randomized clinical trial of three treatments (potassium hydroxide 10%, potassium hydroxide 15%, placebo) applied once daily up to complete clearing of lesions (maximum duration 60 days) in 53 children aged 2-6 years in primary health care pediatric offices in Catalonia, Spain. In the intention-to-treat analysis, potassium hydroxide 10% (58.8%, P = .03) and potassium hydroxide 15% (64.3%, P = .02) had efficacy superior to that of placebo (18.8%). The number of Molluscum contagiosum lesions was significantly reduced with potassium hydroxide 10% and 15%. The main efficacy outcome was achieved in 58.8% of children in the potassium hydroxide 10% group (P = .03 vs placebo) and in 64.3% of children in the potassium hydroxide 15% group (P = .02 vs placebo). Potassium hydroxide 10% and 15% were not significantly different in efficacy from each other. Potassium hydroxide 10% and placebo were better tolerated than potassium hydroxide 15%. No adverse events were reported during the study period. Potassium hydroxide 10% and 15% demonstrated high rates of efficacy in clearing Molluscum contagiosum lesions, with potassium hydroxide 10% being better tolerated. © 2018 Wiley Periodicals, Inc.

Safety Justification and Safety Case for Safety-critical Software in Digital Reactor Protection System

International Nuclear Information System (INIS)

Kwon, Kee-Choon; Lee, Jang-Soo; Jee, Eunkyoung

2016-01-01

Nuclear safety-critical software is under strict regulatory requirements and these regulatory requirements are essential for ensuring the safety of nuclear power plants. The verification & validation (V and V) and hazard analysis of the safety-critical software are required to follow regulatory requirements through the entire software life cycle. In order to obtain a license from the regulatory body through the development and validation of safety-critical software, it is essential to meet the standards which are required by the regulatory body throughout the software development process. Generally, large amounts of documents, which demonstrate safety justification including standard compliance, V and V, hazard analysis, and vulnerability assessment activities, are submitted to the regulatory body during the licensing process. It is not easy to accurately read and evaluate the whole documentation for the development activities, implementation technology, and validation activities. The safety case methodology has been kwon a promising approach to evaluate the level and depth of the development and validation results. A safety case is a structured argument, supported by a body of evidence that provides a compelling, comprehensible, and valid case that a system is safe for a given application in a given operating environment. It is suggested to evaluate the level and depth of the results of development and validation by applying safety case methodology to achieve software safety demonstration. A lot of documents provided as evidence are connected to claim that corresponds to the topic for safety demonstration. We demonstrated a case study in which more systematic safety demonstration for the target system software is performed via safety case construction than simply listing the documents

Safety Justification and Safety Case for Safety-critical Software in Digital Reactor Protection System

Energy Technology Data Exchange (ETDEWEB)

Kwon, Kee-Choon; Lee, Jang-Soo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Jee, Eunkyoung [KAIST, Daejeon (Korea, Republic of)

2016-10-15

Nuclear safety-critical software is under strict regulatory requirements and these regulatory requirements are essential for ensuring the safety of nuclear power plants. The verification & validation (V and V) and hazard analysis of the safety-critical software are required to follow regulatory requirements through the entire software life cycle. In order to obtain a license from the regulatory body through the development and validation of safety-critical software, it is essential to meet the standards which are required by the regulatory body throughout the software development process. Generally, large amounts of documents, which demonstrate safety justification including standard compliance, V and V, hazard analysis, and vulnerability assessment activities, are submitted to the regulatory body during the licensing process. It is not easy to accurately read and evaluate the whole documentation for the development activities, implementation technology, and validation activities. The safety case methodology has been kwon a promising approach to evaluate the level and depth of the development and validation results. A safety case is a structured argument, supported by a body of evidence that provides a compelling, comprehensible, and valid case that a system is safe for a given application in a given operating environment. It is suggested to evaluate the level and depth of the results of development and validation by applying safety case methodology to achieve software safety demonstration. A lot of documents provided as evidence are connected to claim that corresponds to the topic for safety demonstration. We demonstrated a case study in which more systematic safety demonstration for the target system software is performed via safety case construction than simply listing the documents.

75 FR 26094 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Science.gov (United States)

2010-05-11

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago... establishing a temporary safety zone from Brandon Road Lock and Dam to Lake Michigan. This temporary safety...

75 FR 64673 - Safety Zone, Brandon Road Lock and, Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2010-10-20

... Zone, Brandon Road Lock and, Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and... Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Ship and...: The Coast Guard will enforce Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des...

Evaluating software for safety systems in nuclear power plants

International Nuclear Information System (INIS)

Lawrence, J.D.; Persons, W.L.; Preckshot, G.G.; Gallagher, J.

1994-01-01

In 1991, LLNL was asked by the NRC to provide technical assistance in various aspects of computer technology that apply to computer-based reactor protection systems. This has involved the review of safety aspects of new reactor designs and the provision of technical advice on the use of computer technology in systems important to reactor safety. The latter includes determining and documenting state-of-the-art subjects that require regulatory involvement by the NRC because of their importance in the development and implementation of digital computer safety systems. These subjects include data communications, formal methods, testing, software hazards analysis, verification and validation, computer security, performance, software complexity and others. One topic software reliability and safety is the subject of this paper

Conclusions and Recommendations of the IAEA International Conference on Topical Issues in Nuclear Safety: Ensuring Safety for Sustainable Nuclear Development

International Nuclear Information System (INIS)

El-Shanawany, Mamdouh

2011-01-01

Over 200 participants from 33 countries and three international organizations came and actively participated and contributed to focused discussions and the success of the conference. The following points summarize the key conclusions and recommendations of the conference with respect to nuclear safety. 1. The nuclear safety approach is based on the philosophy developed in the 60's: defense in depth principles and deterministic criteria. When properly applied and completed by probabilistic analyses and operational experience feedback, it continues to be a successful approach. However, guarding against the risk of accidents requires constant vigilance and high technical competence and a never ending fight against complacency. In this context, having a strong leadership with a commitment to continuous improvement and a vision of sustained excellence is a key element of nuclear safety. Continuous improvement in safety also should be pursued through scientific research and operational experience feedback. 2. An accident anywhere is of concern to all Member States. Therefore, it is in the interest of all Member States to share and collaborate on safety matters. Participation of all Member States in international nuclear safety instruments and conventions, including liability for nuclear damage, is considered beneficial to global safety. The Convention on Nuclear Safety, the Joint Convention, international cooperation through IAEA and other organizations, bilateral or multilateral arrangements are important elements for establishing networks for sharing and transferring knowledge. It is acknowledged that the IAEA's Safety Fundamentals and Safety Requirements provide a sound foundation for high level nuclear safety. IAEA Safety Standards should be the basis for the establishment and maintenance of safety infrastructure. The IAEA's peer reviews and services such as IRRS, OSART, Site Evaluation and Reactor Safety Reviews provide also a valuable platform for sharing

Main Conclusions and Recommendations of International Conference on Topical Issues in Nuclear Installation Safety: Ensuring Safety for Sustainable Nuclear Development

International Nuclear Information System (INIS)

El-Shanawany, Mamdouh

2011-01-01

Over 200 participants from 33 countries and three international organizations came and actively participated and contributed to focused discussions and the success of the conference. The following points summarize the key conclusions and recommendations of the conference with respect to nuclear safety. 1. The nuclear safety approach is based on the philosophy developed in the 60's: defense in depth principles and deterministic criteria. When properly applied and completed by probabilistic analyses and operational experience feedback, it continues to be a successful approach. However, guarding against the risk of accidents requires constant vigilance and high technical competence and a never ending fight against complacency. In this context, having a strong leadership with a commitment to continuous improvement and a vision of sustained excellence is a key element of nuclear safety. Continuous improvement in safety also should be pursued through scientific research and operational experience feedback. 2. An accident anywhere is of concern to all Member States. Therefore, it is in the interest of all Member States to share and collaborate on safety matters. Participation of all Member States in international nuclear safety instruments and conventions, including liability for nuclear damage, is considered beneficial to global safety. The Convention on Nuclear Safety, the Joint Convention, international cooperation through IAEA and other organizations, bilateral or multilateral arrangements are important elements for establishing networks for sharing and transferring knowledge. It is acknowledged that the IAEA's Safety Fundamentals and Safety Requirements provide a sound foundation for high level nuclear safety. IAEA Safety Standards should be the basis for the establishment and maintenance of safety infrastructure. The IAEA's peer reviews and services such as IRRS, OSART, Site Evaluation and Reactor Safety Reviews provide also a valuable platform for sharing

Regulatory Information By Topic

Science.gov (United States)

EPA develops and enforces regulations that span many environmental topics, from acid rain reduction to wetlands restoration. Each topic listed below may include related laws and regulations, compliance enforcement information, policies guidance

Efficacy and safety of topical Trikatu preparation in, relieving mosquito bite reactions: a randomized controlled trial.

Science.gov (United States)

Maenthaisong, Ratree; Chaiyakunapruk, Nathorn; Tiyaboonchai, Waree; Tawatsin, Apiwat; Rojanawiwat, Archawin; Thavara, Usavadee

2014-02-01

Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 healthy volunteers to determine efficacy and safety of topical Trikatu on mosquito bite reactions. All subjects were bitten by Aedes aegypti laboratory mosquitoes on their forearms and they were randomly assigned arms to apply either Trikatu or reference product on the mosquito bite papule. The main outcome was the difference of papule size reduction at 30 min, measured by a caliper, between the Trikatu and reference arms. Pruritis, redness, pain, and patient satisfaction were assessed at 15, 30, 60, 180, and 360 min as secondary outcomes. There were no significant differences between treatment and reference arms on any outcome at any time of measurement. Trikatu did not show additional effects for relieving mosquito bite reaction as compared with the reference product containing camphor, menthol, and eucalyptus. For further study, it is very important to consider a proper selection of subjects, comparator product, and concentration of extract when Trikatu preparation is investigated. Copyright © 2013 Elsevier Ltd. All rights reserved.

Collegiate Aviation Research and Education Solutions to Critical Safety Issues

Science.gov (United States)

Bowen, Brent (Editor)

2002-01-01

This Conference Proceedings is a collection of 6 abstracts and 3 papers presented April 19-20, 2001 in Denver, CO. The conference focus was "Best Practices and Benchmarking in Collegiate and Industry Programs". Topics covered include: satellite-based aviation navigation; weather safety training; human-behavior and aircraft maintenance issues; disaster preparedness; the collegiate aviation emergency response checklist; aviation safety research; and regulatory status of maintenance resource management.

Regulatory oversight report 2008 concerning nuclear safety in Swiss nuclear installations

International Nuclear Information System (INIS)

2009-04-01

This annual report issued by the Swiss Federal Nuclear Inspectorate (ENSI) reports on the work carried out by the Inspectorate in 2008. This report reviews the regulatory activities in the four Swiss nuclear power stations and in four further nuclear installations in various Swiss research facilities. It deals with topics such as operational details, technologies in use, radiation protection, radioactive wastes, emergency dispositions, personnel and provides an assessment of operations from the safety point of view. Also, the transportation of nuclear materials - both nuclear fuels and nuclear wastes - is reported on. General topics discussed include probabilistic safety analyses and accident management, earthquake damage analysis and agreements on nuclear safety. The underground disposal of highly-radioactive nuclear wastes and work done in the rock laboratories are discussed, as are proposals for additional nuclear power stations

Safety for Users

CERN Multimedia

HR Department

2008-01-01

CERN welcomes more than 8000 Users every year. The PH Department as host to these scientific associates requires the highest safety standards. The PH Safety Office has published a Safety Flyer for Users. Important safety topics and procedures are presented. Although the Flyer is intended primarily to provide safety information for Users, the PH Safety Office invites all those on the CERN sites to keep a copy of the flyer as it gives guidance in matters of safety and explains what to do in the event of an emergency. Link: http://ph-dep.web.cern.ch/ph-dep/Safety/SafetyOffice.html PH-Safety Office PH Department

Safety for Users

CERN Multimedia

HR Department

2008-01-01

CERN welcomes more than 8000 Users every year. The PH Department as host to these scientific associates requires the highest safety standards. The PH Safety Office has published a safety flyer for Users. Important safety topics and procedures are presented. Although the flyer is intended primarily to provide safety information for Users, the PH Safety Office invites all those on the CERN sites to keep a copy of the flyer as it gives guidance in matters of safety and explains what to do in the event of an emergency. The flyer is available at: http://ph-dep.web.cern.ch/ph-dep/Safety/SafetyOffice.html PH-Safety Office PH Department

Communication of geo-scientific safety arguments

International Nuclear Information System (INIS)

Flavelle, P.; Goodwin, B.; Jensen, M.; Linden, R.; Mazurek, M.; Srivastave, M.; Strom, A.; Sudicky, E.; Voinis, S.

2007-01-01

Working Group B addressed the communication of geo-scientific safety arguments through a discussion of practical experience as it related to the methods, types of information and specific arguments found to best communicate geo-scientific concepts and notions of safety with broad audiences including, colleagues, authorities and regulators, political decision makers, academics, and the general public. The following questions were suggested by the programme committee of the AMIGO-2 workshop for discussion by Working Group B with respect to the communication of geo-scientific information and safety arguments: - What is the place of geo-scientific arguments in relation to quantitative and qualitative topics like scenario and FEPs (features, events, processes) assessment, simulated repository evolution, calculated dose or risk impacts, engineering tests of materials, etc., when presenting a safety case to different audiences and with respect to the various stages of the repository programme? (see section 3). - Would we be better off focusing messages to the public on time scales of a few hundred years or a few generations? (see section 4). - How do you handle the fact that geoscience interpretations seldom are unique and data often are open to various interpretations? (see section 5). - How do you handle expert controversy on a specific topic? (see section 6). (authors)

The efficacy and safety of topical administration of tranexamic acid in spine surgery: a meta-analysis.

Science.gov (United States)

Luo, Wei; Sun, Ru-Xin; Jiang, Han; Ma, Xin-Long

2018-04-24

We conducted a meta-analysis from randomized controlled trials (RCTs) and non-RCTs to assess the efficacy and safety of tranexamic acid (TXA) in spine surgery. Potentially relevant academic articles were identified from the Cochrane Library, MEDLINE (1966-2017.11), PubMed (1966-2017.11), Embase (1980-2017.11), and ScienceDirect (1985-2017.11). Secondary sources were identified from the references of the included literature. The pooled data were analyzed using RevMan 5.1. Three RCTs and one non-RCT met the inclusion criteria. There were significant differences in total blood loss (MD = - 267.53, 95% CI - 373.04 to - 106.02, P < 0.00001), drainage volume (MD = - 157.00, 95% CI - 191.17 to - 122.84, P < 0.00001), postoperative hemoglobin level (MD = 0.95, 95% CI 0.44 to 1.47, P = 0.0003), and length of hospital stay (MD = - 1.42, 95% CI - 1.92 to - 0.93, P < 0.00001). No significant differences were found regarding transfusion requirement, deep vein thrombosis (DVT), pulmonary embolism (PE), wound hematoma, and infection between the two groups. The present meta-analysis indicated that the topical application of TXA in spinal surgery decreases the total blood loss and drainage volume and preserves higher postoperative hemoglobin level without increasing the risk of DVT infection, hematoma, DVT, and PE.

E-Alerts: Environmental pollution and control (environmental health and safety). E-mail newsletter

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-04-01

Topics of discussion include the following: Effects of pollution on public health and safety; Toxicology; Industrial health; Physiology; Psychology; Clinical medicine; Radiobiology; Animals used as research experimental models.

76 FR 23524 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2011-04-27

...-AA00 Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago... safety zone from Brandon Road Lock and Dam to Lake Michigan. This proposed safety zone will cover 77.... This TIR established a 77 mile long safety zone from Brandon Road Lock to Lake Michigan in Chicago, IL...

46{sup th} Annual meeting on nuclear technology (AMNT 2015). Key topics / Outstanding know-how and sustainable innovations / Enhanced safety and operation excellence

Energy Technology Data Exchange (ETDEWEB)

Schaffrath, Andreas; Scheuerer, Martina [Gesellschaft fuer Anlagen- und Reaktorsicherheit mbH (GRS), Garching (Germany); Oenneby Carina; Benjaminsson, Ulf [Westinghouse Electric Sweden AB, Vaesteraes (Sweden). Europe, Middle East and Africa (EMEA)

2015-11-15

Summary report on the Topical Sessions ''CFD Simulations for Reactor Safety Relevant Objectives '' and ''Fuel Management During the Last Cycles and Beyond'' of the 46th Annual Conference on Nuclear Technology (AMNT 2015) held in Berlin, 5 to 7 May 2015. Other Sessions of AMNT 2015 have been covered in atw 7 to 10 (2015) and will be covered in further issues of atw.

Pacific Northwest Laboratory annual report for 1988 to the Assistant Secretary for Environment, Safety, and Health: Part 5, Environment, safety, health, and quality assurance

International Nuclear Information System (INIS)

Faust, L.G.; Pennell, W.T.; Selby, J.M.

1989-02-01

This document summarizes the research programs now underway at Battelle's Pacific Northwest Laboratory in the areas of environmental safety, health, and quality assurance. Topics include internal irradiation, emergency plans, dose equivalents, risk assessment, dose equivalents, surveys, neutron dosimetry, and radiation accidents

Development of several data bases related to reactor safety research including probabilistic safety assessment and incident analysis at JAERI

International Nuclear Information System (INIS)

Kobayashi, Kensuke; Oikawa, Tetsukuni; Watanabe, Norio; Izumi, Fumio; Higuchi, Suminori

1986-01-01

Presented are several databases developed at JAERI for reactor safety research including probabilistic safety assessment and incident analysis. First described are the recent developments of the databases such as 1) the component failure rate database, 2) the OECD/NEA/IRS information retrieval system, 3) the nuclear power plant database and so on. Then several issues are discussed referring mostly to the operation of the database (data input and transcoding) and to the retrieval and utilization of the information. Finally, emphasis is given to the increasing role which artifitial intelligence techniques such as natural language treatment and expert systems may play in improving the future capabilities of the databases. (author)

Safety and Security Interface Technology Initiative

Energy Technology Data Exchange (ETDEWEB)

Dr. Michael A. Lehto; Kevin J. Carroll; Dr. Robert Lowrie

2007-05-01

Safety and Security Interface Technology Initiative Mr. Kevin J. Carroll Dr. Robert Lowrie, Dr. Micheal Lehto BWXT Y12 NSC Oak Ridge, TN 37831 865-576-2289/865-241-2772 carrollkj@y12.doe.gov Work Objective. Earlier this year, the Energy Facility Contractors Group (EFCOG) was asked to assist in developing options related to acceleration deployment of new security-related technologies to assist meeting design base threat (DBT) needs while also addressing the requirements of 10 CFR 830. NNSA NA-70, one of the working group participants, designated this effort the Safety and Security Interface Technology Initiative (SSIT). Relationship to Workshop Theme. “Supporting Excellence in Operations Through Safety Analysis,” (workshop theme) includes security and safety personnel working together to ensure effective and efficient operations. One of the specific workshop elements listed in the call for papers is “Safeguards/Security Integration with Safety.” This paper speaks directly to this theme. Description of Work. The EFCOG Safety Analysis Working Group (SAWG) and the EFCOG Security Working Group formed a core team to develop an integrated process involving both safety basis and security needs allowing achievement of the DBT objectives while ensuring safety is appropriately considered. This effort garnered significant interest, starting with a two day breakout session of 30 experts at the 2006 Safety Basis Workshop. A core team was formed, and a series of meetings were held to develop that process, including safety and security professionals, both contractor and federal personnel. A pilot exercise held at Idaho National Laboratory (INL) in mid-July 2006 was conducted as a feasibility of concept review. Work Results. The SSIT efforts resulted in a topical report transmitted from EFCOG to DOE/NNSA in August 2006. Elements of the report included: Drivers and Endstate, Control Selections Alternative Analysis Process, Terminology Crosswalk, Safety Basis

Topical capsaicin for pain in osteoarthritis: A literature review.

Science.gov (United States)

Guedes, Vânia; Castro, João Paulo; Brito, Iva

Osteoarthritis is the most common joint disorder worldwide. The predominant symptom, pain, is usually treated with acetaminophen or oral non-steroidal anti-inflammatory drugs, although they are associated with a significant risk of side effects. Topical capsaicin may represent an effective and safe alternative. The aim of this review is to examine the evidence for the efficacy and safety profile of topical capsaicin in the management of pain caused by osteoarthritis. Databases were searched for articles published between 2004 and 2016, in Portuguese, English or Spanish, using the search terms "capsaicin" and "osteoarthritis". When compared to placebo, it was found that topical capsaicin has a good safety profile and efficacy in reducing osteoarthritis pain of the hand, knee, hip or shoulder. However, the studies have significant limitations, the most important the difficulty of blinding. It is attributed to this review the strength of recommendation B. Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.

Study of fast reactor safety test facilities. Preliminary report

International Nuclear Information System (INIS)

Bell, G.I.; Boudreau, J.E.; McLaughlin, T.; Palmer, R.G.; Starkovich, V.; Stein, W.E.; Stevenson, M.G.; Yarnell, Y.L.

1975-05-01

Included are sections dealing with the following topics: (1) perspective and philosophy of fast reactor safety analysis; (2) status of accident analysis and experimental needs; (3) experiment and facility definitions; (4) existing in-pile facilities; (5) new facility options; and (6) data acquisition methods

ITER safety

International Nuclear Information System (INIS)

Raeder, J.; Piet, S.; Buende, R.

1991-01-01

As part of the series of publications by the IAEA that summarize the results of the Conceptual Design Activities for the ITER project, this document describes the ITER safety analyses. It contains an assessment of normal operation effluents, accident scenarios, plasma chamber safety, tritium system safety, magnet system safety, external loss of coolant and coolant flow problems, and a waste management assessment, while it describes the implementation of the safety approach for ITER. The document ends with a list of major conclusions, a set of topical remarks on technical safety issues, and recommendations for the Engineering Design Activities, safety considerations for siting ITER, and recommendations with regard to the safety issues for the R and D for ITER. Refs, figs and tabs

2011 annual meeting on nuclear technology. Pt. 4. Topical sessions

International Nuclear Information System (INIS)

Schoenfelder, Christian; Dams, Wolfgang

2011-01-01

Summary report on the Topical Session of the Annual Conference on Nuclear Technology held in Berlin, 17 to 19 May 2011: - Nuclear Competence in Germany and Europe. The Topical Session: - Sodium Cooled Fast Reactors -- will be covered in a report in a further issue of atw. The reports on the Topical Sessions: - CFD-Simulations for Safety Relevant Tasks; and - Final Disposal: From Scientific Basis to Application; - Characteristics of a High Reliability Organization (HRO) Considering Experience Gained from Events at Nuclear Power Stations -- have been covered in atw 7, 8/9, and 10 (2011). (orig.)

Topical minoxidil: cardiac effects in bald man.

Science.gov (United States)

Leenen, F H; Smith, D L; Unger, W P

1988-01-01

Systemic cardiovascular effects during chronic treatment with topical minoxidil vs placebo were evaluated using a double-blind, randomized design for two parallel groups (n = 20 for minoxidil, n = 15 for placebo). During 6 months of follow-up, blood pressure did not change, whereas minoxidil increased heart rate by 3-5 beats min-1. Compared with placebo, topical minoxidil caused significant increases in LV end-diastolic volume, in cardiac output (by 0.751 min-1) and in LV mass (by 5 g m-2). We conclude that in healthy subjects short-term use of topical minoxidil is likely not to be detrimental. However, safety needs to be established regarding ischaemic symptoms in patients with coronary artery disease as well as for the possible development of LV hypertrophy in healthy subjects during years of therapy. PMID:3191000

Pacific Northwest Laboratory annual report for 1988 to the Assistant Secretary for Environment, Safety, and Health: Part 5, Environment, safety, health, and quality assurance

Energy Technology Data Exchange (ETDEWEB)

Faust, L.G.; Pennell, W.T.; Selby, J.M.

1989-02-01

This document summarizes the research programs now underway at Battelle's Pacific Northwest Laboratory in the areas of environmental safety, health, and quality assurance. Topics include internal irradiation, emergency plans, dose equivalents, risk assessment, dose equivalents, surveys, neutron dosimetry, and radiation accidents. (TEM)

Workplace Safety and Health Topics: Diseases and Injuries

Science.gov (United States)

... December 28, 2017 Content source: National Institute for Occupational Safety and Health Education and Information Division Email Recommend Tweet YouTube Instagram Listen Watch RSS ABOUT About CDC Jobs Funding LEGAL Policies Privacy FOIA No Fear Act OIG 1600 Clifton Road Atlanta , GA 30329-4027 ...

Parents' attitudes towards topical fluoride and vaccines for children: Are these distinct or overlapping phenomena?

Directory of Open Access Journals (Sweden)

Richard M. Carpiano

2018-06-01

Full Text Available Despite attention paid to parental refusal of child vaccines, the phenomenon of topical fluoride refusal is poorly understood. We examine the extent to which parent attitudes and Internet use regarding topical fluoride treatment and vaccines may overlap and, in turn, uniquely or distinctly correlate with fluoride and vaccine refusal for the child. In 2017, we analyzed data collected from 2011 to 12 for 361 children from three Washington state dental clinics. The instrument included analogous measures of topical fluoride and vaccine safety concerns, perceived severity of preventable cavities/disease, and Internet use for fluoride/vaccine information; and measures of non-fluoridated toothpaste use, attitudes towards dental x-rays and amalgam and composite fillings. We assessed dental chart-based topical fluoride refusal occurring in 2009 or 2010 and parent-reported vaccine refusal. All analogous fluoride and vaccine items were substantively correlated. However, in a series of adjusted models, none of these items were significantly associated with fluoride refusal. Multiple fluoride and vaccine items were associated with vaccine refusal in unadjusted models; but only vaccine safety concerns, perceived severity of a preventable cavity, and Internet use for vaccine information remained significant in adjusted models. Although there is concordance between the two refusal behaviors as well as analogous attitudes and Internet use, these findings challenge the idea that fluoride refusal should be addressed with interventions focusing on vaccine refusal. Further research is required on the factors underlying refusal of preventive dental care. Keywords: Vaccinations, Topical fluoride, Vaccination refusal, Fluoride refusal, Vaccine hesitancy, Fluoride hesitancy, Children, Adolescents, Preventive treatment, United States

Construction safety program for the National Ignition Facility, Appendix A

International Nuclear Information System (INIS)

Cerruti, S.J.

1997-01-01

Topics covered in this appendix include: General Rules-Code of Safe Practices; 2. Personal Protective Equipment; Hazardous Material Control; Traffic Control; Fire Prevention; Sanitation and First Aid; Confined Space Safety Requirements; Ladders and Stairways; Scaffolding and Lift Safety; Machinery, Vehicles, and Heavy Equipment; Welding and Cutting-General; Arc Welding; Oxygen/Acetylene Welding and Cutting; Excavation, Trenching, and Shoring; Fall Protection; Steel Erection; Working With Asbestos; Radiation Safety; Hand Tools; Electrical Safety; Nonelectrical Work Performed Near Exposed High-Voltage Power-Distribution Equipment; Lockout/Tagout Requirements; Rigging; A-Cranes; Housekeeping; Material Handling and Storage; Lead; Concrete and Masonry Construction

Construction safety program for the National Ignition Facility, Appendix A

Energy Technology Data Exchange (ETDEWEB)

Cerruti, S.J.

1997-06-26

Topics covered in this appendix include: General Rules-Code of Safe Practices; 2. Personal Protective Equipment; Hazardous Material Control; Traffic Control; Fire Prevention; Sanitation and First Aid; Confined Space Safety Requirements; Ladders and Stairways; Scaffolding and Lift Safety; Machinery, Vehicles, and Heavy Equipment; Welding and Cutting-General; Arc Welding; Oxygen/Acetylene Welding and Cutting; Excavation, Trenching, and Shoring; Fall Protection; Steel Erection; Working With Asbestos; Radiation Safety; Hand Tools; Electrical Safety; Nonelectrical Work Performed Near Exposed High-Voltage Power-Distribution Equipment; Lockout/Tagout Requirements; Rigging; A-Cranes; Housekeeping; Material Handling and Storage; Lead; Concrete and Masonry Construction.

Safety culture: the concept and its practical application

International Nuclear Information System (INIS)

Edmondson, B.

1994-01-01

This paper draws together a number of topics concerned with safety culture: the first part of the paper describe the characteristics of an organisation giving rise to a good safety culture as suggested in INSAG-4. The second part of the paper examines sources of information on the characteristics of organisations giving rise to good and poor safety performance including a study into the causes of a number of recent severe accidents such as Clapham Junction and Piper Alpha. The final part of the paper describes the means by which safety culture within an organisation may be measured and therefore controlled. This enables an organisation to provide for a good safety culture and improve commercial performance by a process of continuous safety improvement eliminating the losses arising from poor safety standards. (author) 6 tabs., 5 refs

A Case Report of Severe Corneal Toxicity following 0.5% Topical Moxifloxacin Use

Directory of Open Access Journals (Sweden)

A.P. Vignesh

2015-02-01

Full Text Available Moxifloxacin is a widely used topical antibiotic in various bacterial infections of the eye. Its safety and efficacy have been proved by many studies. We report a case of a rare adverse effect following its use. A 10-year-old female who had presented with acute bacterial conjunctivitis in both eyes with no corneal involvement was started on preservative-free 0.5% topical moxifloxacin four times a day. The child developed a severe form of corneal toxicity in both eyes with circumcorneal congestion and corneal edema following its use. The child's visual acuity had dropped from 20/20 to 20/400 in both the eyes. Topical moxifloxacin was discontinued, following which the cornea cleared dramatically and the visual acuity became normal. This case indicates that though rare, topical moxifloxacin can cause severe keratitis and that more studies need to be conducted to evaluate its safety.

Proceedings of the Twenty-First Water Reactor Safety Information Meeting: Volume 1, Plenary session; Advanced reactor research; advanced control system technology; advanced instrumentation and control hardware; human factors research; probabilistic risk assessment topics; thermal hydraulics; thermal hydraulic research for advanced passive LWRs

International Nuclear Information System (INIS)

Monteleone, S.

1994-04-01

This three-volume report contains 90 papers out of the 102 that were presented at the Twenty-First Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, during the week of October 25--27, 1993. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Germany, Japan, Russia, Switzerland, Taiwan, and United Kingdom. The titles of the papers and the names of the authors have been updated and may differ from those that appeared in the final program of the meeting. Individual papers have been cataloged separately. This document, Volume 1 covers the following topics: Advanced Reactor Research; Advanced Instrumentation and Control Hardware; Advanced Control System Technology; Human Factors Research; Probabilistic Risk Assessment Topics; Thermal Hydraulics; and Thermal Hydraulic Research for Advanced Passive Light Water Reactors

Proceedings of the Twenty-First Water Reactor Safety Information Meeting: Volume 1, Plenary session; Advanced reactor research; advanced control system technology; advanced instrumentation and control hardware; human factors research; probabilistic risk assessment topics; thermal hydraulics; thermal hydraulic research for advanced passive LWRs

Energy Technology Data Exchange (ETDEWEB)

Monteleone, S. [Brookhaven National Lab., Upton, NY (United States)] [comp.

1994-04-01

This three-volume report contains 90 papers out of the 102 that were presented at the Twenty-First Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, during the week of October 25--27, 1993. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Germany, Japan, Russia, Switzerland, Taiwan, and United Kingdom. The titles of the papers and the names of the authors have been updated and may differ from those that appeared in the final program of the meeting. Individual papers have been cataloged separately. This document, Volume 1 covers the following topics: Advanced Reactor Research; Advanced Instrumentation and Control Hardware; Advanced Control System Technology; Human Factors Research; Probabilistic Risk Assessment Topics; Thermal Hydraulics; and Thermal Hydraulic Research for Advanced Passive Light Water Reactors.

The Paget Trial: A Multicenter, Observational Cohort Intervention Study for the Clinical Efficacy, Safety, and Immunological Response of Topical 5% Imiquimod Cream for Vulvar Paget Disease.

Science.gov (United States)

van der Linden, Michelle; Meeuwis, Kim; van Hees, Colette; van Dorst, Eleonora; Bulten, Johan; Bosse, Tjalling; IntHout, Joanna; Boll, Dorry; Slangen, Brigitte; van Seters, Manon; van Beurden, Marc; van Poelgeest, Mariëtte; de Hullu, Joanne

2017-09-06

Vulvar Paget disease is a rare skin disorder, which is most common in postmenopausal Caucasian women. They usually present with an erythematous plaque that may show fine or typical "cake icing" scaling or ulceration that may cause itching, pain, irritation, or a burning sensation. Although most cases are noninvasive, vulvar Paget disease may be invasive or associated with an underlying vulvar or distant adenocarcinoma. The histological evidence of so-called "Paget cells" with abundant pale cytoplasm in the epithelium confirms the diagnosis. The origin of these Paget cells is still unclear. Treatment of choice is wide local excision with negative margins. Obtaining clear surgical margins is challenging and may lead to extensive and mutilating surgery. Even then, recurrence rates are high, ranging from 15% to 70%, which emphasizes the need for new treatment options. A number of case reports, retrospective case series, and one observational study have shown promising results using the topical immune response modifier imiquimod. This study aims to investigate the efficacy, safety, and immunological response in patients with noninvasive vulvar Paget disease using a standardized treatment schedule with 5% imiquimod cream. Topical 5% imiquimod cream might be an effective and safe treatment alternative for vulvar Paget disease. The Paget Trial is a multicenter observational cohort study including eight tertiary referral hospitals in the Netherlands. It is ethically approved by the Medical-Ethical Committee of Arnhem-Nijmegen and registered in the Central Committee on Research Involving Human Subjects (CCMO) Register by as NL51648.091.14. Twenty patients with (recurrent) noninvasive vulvar Paget disease will be treated with topical 5% imiquimod cream three times a week for 16 weeks. The primary efficacy outcome is the reduction in lesion size at 12 weeks after end of treatment. Secondary outcomes are safety, immunological response, and quality of life. Safety will be

Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial.

Science.gov (United States)

Jabbari, Marzie; Hashempur, Mohammad Hashem; Razavi, Seyede Zahra Emami; Shahraki, Hadi Raeisi; Kamalinejad, Mohammad; Emtiazy, Majid

2016-07-21

Sambucus ebulus L. (S. ebulus) has had long-standing application in Traditional Persian Medicine for joint pain and for a variety of bone and joint disorders. According to traditional use of S. ebulus and its relevant pharmacologic properties, this study was designed to evaluate the efficacy and short-term safety of topical use of S. ebulus in patients with knee osteoarthritis (OA). Seventy nine patients with knee OA were randomly enrolled in 2 parallel arms of a pilot randomized, double-blind, active-controlled clinical trial. The patients were treated by topical S. ebulus gel or 1% diclofenac gel, three times a day, as much as a fingertip unit for 4 weeks. Patients were assessed prior to enrollment and, then, 2 and 4 weeks subsequent to the intervention, in terms of scores of visual analogue scale (VAS) for self-grading of their knee joint pain, and according to 3 different domains of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Any observed adverse effects were also scrutinized. The mean values of WOMAC pain score, total WOMAC score and VAS score for pain of the S. ebulus group were significantly lower compared with the diclofenac group (P=0.004, P=0.04, and P<0.001, respectively). In addition, no serious adverse effect was reported. This pilot study showed that topical treatment with S. ebulus gel can be recommended for alleviating symptoms of patients with knee OA. However, longer trials involving larger samples size, are needed for achieving a comprehensive understanding about the efficacy and safety of S. ebulus in knee OA. Copyright © 2016. Published by Elsevier Ireland Ltd.

Topical study on IRS events involving foreign material intrusion in plant systems. First issue. Report of a consultants meeting. Working material

International Nuclear Information System (INIS)

1997-01-01

Recent exchange of operational safety experience among countries, within the framework of the IRS, revealed a noticeable increase in incidents involving foreign material intrusion (FMI) in nuclear power plant systems. These incidents appeared to have safety impact, sometimes widespread, on many systems and components, including the reactor core, control rods, the secondary side, and other support systems such as the electrical, air, and water systems. Notwithstanding the economic penalties and the operational problems that can arise from the FMI, many events indicated severe component damages, challenges to safety systems and to fuel integrity. Difficulties encountered with the removal of foreign material present further challenges due to the long term effects of such material remaining in the system and interacting with either fuel cladding, with the potential of releasing fission products in coolant systems, or with the system pressure boundary with the potential for material wear and sudden failure of the pressure boundary. The FMI topic was, therefore, one of a number of topics that was recommended by the TCM in 1996 for investigation. A consultant meeting was held at the IAEA during the period 14-18 April 1997 to address this topic. Figs

Topical corticosteroids as adjunctive therapy for bacterial keratitis

Science.gov (United States)

Herretes, Samantha; Wang, Xue; Reyes, Johann MG

2014-01-01

Background Bacterial keratitis is a serious ocular infectious disease that can lead to severe visual disability. Risk factors for bacterial corneal infection include contact lens wear, ocular surface disease, corneal trauma, and previous ocular or eyelid surgery. Topical antibiotics constitute the mainstay of treatment in cases of bacterial keratitis, whereas the use of topical corticosteroids as an adjunctive therapy to antibiotics remains controversial. Topical corticosteroids are usually used to control inflammation using the smallest amount of the drug. Their use requires optimal timing, concomitant antibiotics, and careful follow-up. Objectives The objective of the review was to assess the effectiveness and safety of corticosteroids as adjunctive therapy for bacterial keratitis. Secondary objectives included evaluation of health economic outcomes and quality of life outcomes. Search methods We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (2014, Issue 6), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to July 2014), EMBASE (January 1980 to July 2014), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to July 2014), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 14 July 2014. We also searched the Science Citation Index to identify additional studies that had cited the only trial included in the original version of this review, reference lists of included trials, earlier reviews, and the American Academy of Ophthalmology guidelines. We also contacted experts to identify any unpublished and

Recent Advances In Topical Therapy In Dermatology

Directory of Open Access Journals (Sweden)

Mohan Thappa Devinder

2003-01-01

Full Text Available With changing times various newer topical agents are introduced in the field of dermatology. Tacrolimus and pimecrolimus are immunisuppressants, which are effective topically and are tried in the management of atopic dermatitis as well as other disorders including allergic contact dermatitis, atrophic lichen planus, pyoderma gangrenosum. Imiquimod, an immune response modifier, is presently in use for genital warts but has potentials as anti- tumour agent and in various other dermatological conditions when used topically. Tazarotene is a newer addition to the list of topical reginoids, which is effective in psoriasis and has better effect in combination with calcipotriene, phototherapy and topical costicosteroids. Tazarotene and adapelene are also effective in inflammatory acne. Calcipotriol, a vitamin D analogue has been introduced as a topical agent in the treatment of psoriasis. Steroid components are also developed recently which will be devoid of the side effects but having adequate anti-inflammatory effect. Topical photodynamic therapy has also a wide range of use in dermatology. Newer topical agents including cidofovir, capsaicin, topical sensitizers, topical antifungal agents for onychomycosis are also of use in clinical practice. Other promising developments include skin substitutes and growth factors for wound care.

NS [Nuclear Safety] update. Current safety and security activities and developments taking place in the Department of Nuclear Safety and Security, Issue no. 12, September 2009

International Nuclear Information System (INIS)

2009-09-01

The current issue presents information about the following topics: Nuclear Security Report 2009; G8 Nuclear Safety and Security Group (NSSG); Uranium Production Site Appraisal Team (UPSAT); New Entrant Nuclear Power Programmes Safety Guide on the Establishment of the Safety Infrastructure (DS424)

The management of health and safety at Atomic Weapons Establishment premises. Pt. 2: Detailed findings

International Nuclear Information System (INIS)

1994-10-01

A review of the management of health and safety and the standards of risk control at premises run by Atomic Weapons Establishment plc (AWE) in the United Kingdom was completed in January 1994. This second volume of the review report records the findings relating to the eight health and safety topics chosen as the focus of the review because they provide evidence from AWE's key areas of activity. The topics are: Layard identification and risk assessment; operations; maintenance; research and experimentation; new facilities and modifications; decommissioning and waste; emergency preparedness; and health and safety specialist function. The Health and Safety Executive review team spent time at each of the four main AWE sites and observed an emergency exercise at Aldermaston. A report on the emergency exercise is included as an appendix. (UK)

Plutonium ocean shipment safety between Europe and Japan

International Nuclear Information System (INIS)

Pierce, J.D.; Hohnstreiter, G.F.; McClure, J.D.; Smith, J.D.; Dukart, R.J.; Koski, J.A.; Braithwate, J.W.; Sorenson, N.R.; Yamamoto, K.; Kitamura, T.; Shibata, K.; Ouchi, Y.; Ito, T.

2004-01-01

Sandia National Laboratories (SNL) and Japan Nuclear Cycle Development Institute (JNC) have conducted an extensive emergency response planning study of the safety of the sea transport of plutonium for JNC. This study was conducted in response to international concerns about the safety of the marine transport of PuO2 powder that began with the sea transport of plutonium powder from France to Japan in 1992 using a purposebuilt ship. This emergency response planning study addressed four topics to better define the accident environment for long-range sea transport of nuclear materials. The first topic is a probabilistic safety analysis that evaluates the technical issues of transporting plutonium between Europe and Japan. An engine-room fire aboard a purposebuilt ship is evaluated as the second topic to determine the vulnerability and safety margin of radioactive material packaging for plutonium designed to meet International Atomic Energy Agency (IAEA) standards. The third topic is a corrosion study performed for generic plutonium packaging to estimate the time required to breach the containment boundary in the event of submersion in seawater. The final study topic is a worldwide survey of information on high-value cargo salvage capabilities from sunken ships. The primary purpose of this overall emergency response planning study is to describe and analyze the safety of radioactive material transportation operations for the international transportation of radioactive materials by maritime cargo vessels

Plutonium ocean shipment safety between Europe and Japan

Energy Technology Data Exchange (ETDEWEB)

Pierce, J D; Hohnstreiter, G F; McClure, J D; Smith, J D; Dukart, R J; Koski, J A; Braithwate, J W; Sorenson, N R [Sandia National Labs., Albuquerque, NM (United States); Yamamoto, K; Kitamura, T; Shibata, K; Ouchi, Y; Ito, T [Japan Nuclear Cycle Development Inst., Tokai-mura (Japan)

2004-07-01

Sandia National Laboratories (SNL) and Japan Nuclear Cycle Development Institute (JNC) have conducted an extensive emergency response planning study of the safety of the sea transport of plutonium for JNC. This study was conducted in response to international concerns about the safety of the marine transport of PuO2 powder that began with the sea transport of plutonium powder from France to Japan in 1992 using a purposebuilt ship. This emergency response planning study addressed four topics to better define the accident environment for long-range sea transport of nuclear materials. The first topic is a probabilistic safety analysis that evaluates the technical issues of transporting plutonium between Europe and Japan. An engine-room fire aboard a purposebuilt ship is evaluated as the second topic to determine the vulnerability and safety margin of radioactive material packaging for plutonium designed to meet International Atomic Energy Agency (IAEA) standards. The third topic is a corrosion study performed for generic plutonium packaging to estimate the time required to breach the containment boundary in the event of submersion in seawater. The final study topic is a worldwide survey of information on high-value cargo salvage capabilities from sunken ships. The primary purpose of this overall emergency response planning study is to describe and analyze the safety of radioactive material transportation operations for the international transportation of radioactive materials by maritime cargo vessels.

Final disposal in deep boreholes using multiple geological barriers. Digging deeper for safety. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Bracke, Guido; Hurst, Stephanie; Merkel, Broder; Mueller, Birgit; Schilling, Frank

2016-03-15

The proceedings of the workshop on final disposal in deep boreholes using multiple geological barriers - digging deeper for safety include contributions on the following topics: international status and safety requirements; geological and physical barriers; deep drilling - shaft building; technical barriers and emplacement technology for high P/T conditions; recovery (waste retrieval); geochemistry and monitoring.

Research program on regulatory safety research

International Nuclear Information System (INIS)

Mailaender, R.

2010-02-01

This paper elaborated for the Swiss Federal Office of Energy (SFOE) presents the synthesis report for 2009 made by the SFOE's program leader on the research program concerning regulatory nuclear safety research, as co-ordinated by the Swiss Nuclear Safety Inspectorate ENSI. Work carried out in various areas is reviewed, including that done on reactor safety, radiation protection and waste disposal as well as human aspects, organisation and safety culture. Work done concerning materials, pressure vessel integrity, transient analysis, the analysis of serious accidents in light-water reactors, fuel and material behaviour, melt cooling and concrete interaction is presented. OECD data bank topics are discussed. Transport and waste disposal research at the Mont Terri rock laboratory is looked at. Requirements placed on the personnel employed in nuclear power stations are examined and national and international co-operation is reviewed

Idaho Safety Manual.

Science.gov (United States)

Idaho State Dept. of Education, Boise. Div. of Vocational Education.

This manual is intended to help teachers, administrators, and local school boards develop and institute effective safety education as a part of all vocational instruction in the public schools of Idaho. This guide is organized in 13 sections that cover the following topics: introduction to safety education, legislation, levels of responsibility,…

Proceedings of the international topical meeting on advanced reactors safety: Volume 2

International Nuclear Information System (INIS)

1997-01-01

In this volume, 89 papers are grouped under the following headings: advances in research/test reactor safety; advanced reactor accident management and emergency actions; advanced reactors instrumentation/controls/human factors; probabilistic risk/safety and reliability assessments; steam explosion research and issues; advanced reactor severe accident issues and research (analysis and assessments); advanced reactor thermal hydraulics; accelerator-driven source safety; liquid-metal reactor safety; structural assessments and issues; late papers

Tornadoes: Nature's Most Violent Storms. A Preparedness Guide Including Safety Information for Schools.

Science.gov (United States)

American National Red Cross, Washington, DC.

This preparedness guide explains and describes tornadoes, and includes safety information for schools. A tornado is defined as a violently rotating column of air extending from a thunderstorm to the ground. The guide explains the cause of tornadoes, provides diagrams of how they form, describes variations of tornadoes, and classifies tornadoes by…

Safety culture in nuclear installations. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Carnino, A [ed.; International Atomic Energy Agency, Vienna (Austria); Weimann, G [ed.; Oesterreichisches Forschungszentrum Seibersdorf GmbH (Austria)

1995-04-01

These proceedings of the International Topical Meeting on Safety Culture in Nuclear Installations held in Vienna, Austria from 24 to 28 April 1995 provide a wide forum of information exchange and discussions on the topic safety culture in nuclear power plants. Safety culture deals with human factors since it deals with attitudes, organization and management. It then means that it has a natural component in it which is linked to the national culture and education. There are about 95 contributions, some of them presented by title and abstract only. All of them are in the subject scope of INIS. (Botek).

Safety culture in nuclear installations. Proceedings

International Nuclear Information System (INIS)

Carnino, A.; Weimann, G.

1995-04-01

These proceedings of the International Topical Meeting on Safety Culture in Nuclear Installations held in Vienna, Austria from 24 to 28 April 1995 provide a wide forum of information exchange and discussions on the topic safety culture in nuclear power plants. Safety culture deals with human factors since it deals with attitudes, organization and management. It then means that it has a natural component in it which is linked to the national culture and education. There are about 95 contributions, some of them presented by title and abstract only. All of them are in the subject scope of INIS. (Botek)

I. Reactor safety (including comments on criticisms of WASH-1400)

International Nuclear Information System (INIS)

1976-01-01

A major concern in any nuclear power programme is a reactor accident resulting in a large release of radioactivity to the environment. Serious reactor accidents are possible and the risk of such accidents cannot be reduced to zero i.e. absolute safety cannot be assured. All that can be expected is that the measures used to ensure safety in the design and operation of a reactor are such that the risk of accident is reduced to acceptably low levels. No member of the general public is known to have died or been injured as a result of an accident in over 1000 commercial nuclear power reactor-years. Some accidents in power reactors in operation today have come close enough to an environmental release of radioactivity to cause serious public concern about future safety. Apparent inadequacies in safety practices disclosed by former members of the nuclear power industry have added to this concern. To obtain an objective appraisal of the reactor safety issue this report examines the measures taken in the design and operation of nuclear reactors to reduce the probability of accident to acceptably low levels

Safety analysis for research reactors

International Nuclear Information System (INIS)

2008-01-01

The aim of safety analysis for research reactors is to establish and confirm the design basis for items important to safety using appropriate analytical tools. The design, manufacture, construction and commissioning should be integrated with the safety analysis to ensure that the design intent has been incorporated into the as-built reactor. Safety analysis assesses the performance of the reactor against a broad range of operating conditions, postulated initiating events and other circumstances, in order to obtain a complete understanding of how the reactor is expected to perform in these situations. Safety analysis demonstrates that the reactor can be kept within the safety operating regimes established by the designer and approved by the regulatory body. This analysis can also be used as appropriate in the development of operating procedures, periodic testing and inspection programmes, proposals for modifications and experiments and emergency planning. The IAEA Safety Requirements publication on the Safety of Research Reactors states that the scope of safety analysis is required to include analysis of event sequences and evaluation of the consequences of the postulated initiating events and comparison of the results of the analysis with radiological acceptance criteria and design limits. This Safety Report elaborates on the requirements established in IAEA Safety Standards Series No. NS-R-4 on the Safety of Research Reactors, and the guidance given in IAEA Safety Series No. 35-G1, Safety Assessment of Research Reactors and Preparation of the Safety Analysis Report, providing detailed discussion and examples of related topics. Guidance is given in this report for carrying out safety analyses of research reactors, based on current international good practices. The report covers all the various steps required for a safety analysis; that is, selection of initiating events and acceptance criteria, rules and conventions, types of safety analysis, selection of

Principles of electrical safety

CERN Document Server

Sutherland, Peter E

2015-01-01

Principles of Electrical Safety discusses current issues in electrical safety, which are accompanied by series' of practical applications that can be used by practicing professionals, graduate students, and researchers. .  Provides extensive introductions to important topics in electrical safety Comprehensive overview of inductance, resistance, and capacitance as applied to the human body Serves as a preparatory guide for today's practicing engineers

Generic safety documentation model

International Nuclear Information System (INIS)

Mahn, J.A.

1994-04-01

This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ''core'' upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information

A systematic review of the evidence for topical use of ginger.

Science.gov (United States)

Ding, Mingshuang; Leach, Matthew J; Bradley, Helen

2013-01-01

The use of ginger as a topical intervention is widely advocated in the popular media. However, there has been no attempt to date to synthesize the evidence for topically administered ginger. To systematically review and synthesize the best available evidence of effectiveness for topical ginger in any condition. CAM on PubMed, CINAHL, Google Scholar, MEDLINE, National Library of Australia, The Cochrane Library, TRIP, pertinent texts, and bibliographies of relevant papers. Data sources were systematically searched for studies investigating the clinical effectiveness of topical ginger, in any form and for any condition, regardless of study design. Studies were limited to those published between 1980 and 2010, and published in English, Mandarin, Cantonese, or Taiwanese. Data were extracted by two authors, independently, using standardized templates. Four studies met the inclusion criteria, including three randomized controlled trials and one non-randomized controlled trial. All studies differed in terms of study population, outcome measures, comparative interventions, and dose and form of ginger used, and thus, were not amenable to meta-analysis. Findings from all trials favored usage of ginger for most outcomes. However, the small sample sizes and inadequate methodological reporting indicate a high risk of bias and the need for caution when interpreting these results. Few studies have investigated the effectiveness of topically administered ginger for any condition. Until the findings of these studies are corroborated by more robust research, and the safety of ginger is adequately established, clinicians should remain cautious about using topical ginger in clinical practice. © 2013 Elsevier Inc. All rights reserved.

Clinical and bacteriological efficacy of twice daily topical retapamulin ointment 1% in the management of impetigo and other uncomplicated superficial skin infections

Directory of Open Access Journals (Sweden)

Benjamin R. Bohaty, MD

2015-02-01

Conclusion: Safety profile appears favorable given the low number of AEs. Study design limits conclusions that can be drawn. Nevertheless, this study supports use of topical retapamulin 1% ointment in treatment of cutaneous bacterial infections, particularly those caused by S. aureus, including MRSA.

Problems of nuclear reactor safety. Vol. 1; Problemy bezopasnosti yaderno-ehnergeticheskikh ustanovok. Tom 1

Energy Technology Data Exchange (ETDEWEB)

Shal` nov, A V [Moskovskij Inzhenerno-Fizicheskij Inst., Moscow (Russian Federation)

1996-12-31

Proceedings of the 9. Topical Meeting `Problems of nuclear reactor safety` are presented. Papers include results of studies and developments associated with methods of calculation and complex computerized simulation for stationary and transient processes in nuclear power plants. Main problems of reactor safety are discussed as well as rector accidents on operating NPP`s are analyzed.

An open randomized comparative study to test the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in the treatment of onychomycosis

Directory of Open Access Journals (Sweden)

Jaiswal Amit

2007-01-01

Full Text Available Background: Onychomycosis is a fungal infection of nails caused by dermatophytes, yeasts and molds. Aims: To study the efficacy and safety of oral terbinafine pulse as a monotherapy and in combination with topical ciclopirox olamine 8% or topical amorolfine hydrochloride 5% in onychomycosis. Methods: A clinical comparative study was undertaken on 96 Patients of onychomycosis during the period between August 2005 to July 2006. Forty-eight patients were randomly assigned in group A to receive oral terbinafine 250 mg, one tablet twice daily for seven days every month (pulse therapy; 24 patients in group B to receive oral terbinafine pulse therapy plus topical ciclopirox olamine 8% to be applied once daily at night on all affected nails; and 24 patients in group C to receive oral terbinafine pulse therapy plus topical amorolfine hydrochloride 5% to be applied once weekly at night on all the affected nails. The treatment was continued for four months. The patients were evaluated at four weekly intervals till sixteen weeks and then at 24 and 36 weeks. Results: We observed clinical cure in 71.73, 82.60 and 73.91% patients in groups A, B and C, respectively; Mycological cure rates against dematophytes were 88.9, 88.9 and 85.7 in groups A, B and C, respectively. The yeast mycological cure rates were 66.7, 100 and 50 in groups A, B and C, respectively. In the case of nondermatophytes, the overall response was poor: one out of two cases (50% responded in group A, while one case each in group B and group C did not respond at all. Conclusion: Terbinafine pulse therapy is effective and safe alternative in treatment of onychomycosis due to dermatophytes; and combination therapy with topical ciclopirox or amorolfine do not show any significant difference in efficacy in comparison to monotherapy with oral terbinafine.

Proceedings of the international symposium on safety related measurements in PWRs: Topic of the first meeting: 'Temperature and level measurements'

International Nuclear Information System (INIS)

2001-09-01

Numerous teams of experts from several countries deal with theme of measurement important for safety operation of WWER reactors. These special teams have a need to meet at various opportunities to change their experience. As an example I can mention meeting of experts from Russia , Germany, France and Slovakia at completion and reconstruction of Slovak NPP, at modernisation of Russian and Bulgarian NPP. Mentioned meetings have invoked an idea of participants to organise a common action aimed at measurement important for safety operation of WWER, that participants can change their experience from mentioned area at welcome environment of symposium. Therefore, at meeting of experts from Siemens, INCOR and VUJE at the end of the year 2000 participants agreed on realisation of such common action. Participants have taken orientation at all safety measurements for very deep topic. Therefore, they have decided in respect of this first meeting of symposium to give consideration to only some special measurements in particular to temperature and surface. In case of interest there is possible to take focus at other type of measurements. Slovakia has been chosen for the first meeting place on basis of economic reasons and also because a number of improvements of standard reactor temperature measuring procedures have been implemented here that over passed its frontiers. In addition the first fail-safe level measuring in reactor pressure vessel has been effectuated in Slovakia

Minocycline down-regulates topical mucosal inflammation during the application of microbicide candidates.

Directory of Open Access Journals (Sweden)

Liangzhu Li

Full Text Available An effective anti-human immunodeficiency virus-1 (HIV-1 microbicide should exert its action in the absence of causing aberrant activation of topical immunity that will increase the risk of HIV acquisition. In the present study, we demonstrated that the vaginal application of cellulose sulfate (CS gel induced topical mucosal inflammatory responses; the addition of minocycline to CS gel could significantly attenuate the inflammation in a mice model. The combined gel of CS plus minocycline not only reduced the production of inflammatory cytokines in cervicovaginal lavages (CVLs, also down-regulated the activation of CD4+ T cells and the recruitment of other immune cells including HIV target cells into vaginal tissues. Furthermore, an In vitro HIV-1 pseudovirus infection inhibition assay showed that the combined gel decreased the infection efficacy of different subtypes of HIV-1 pseudoviruses compared with that of CS gel alone. These results implicate that minocycline could be integrated into microbicide formulation to suppress the aberrant activation of topical mucosal immunity and enhance the safety profile during the application of microbicides.

Laboratory Safety in the Biology Lab.

Science.gov (United States)

Ritch, Donna; Rank, Jane

2001-01-01

Reports on a research project to determine if students possess and comprehend basic safety knowledge. Shows a significant increase in the amount of safety knowledge gained when students are exposed to various topics in laboratory safety and are held accountable for learning the information as required in a laboratory safety course. (Author/MM)

Proceedings of the 1992 topical meeting on advances in reactor physics

International Nuclear Information System (INIS)

1992-01-01

This document, Volume 2, presents proceedings of the 1992 Topical Meeting on Advances in Reactor Physics on March 8--11, 1992 at Charleston, SC. Session topics were as follows: Transport Theory; Fast Reactors; Plant Analyzers; Integral Experiments/Measurements ampersand Analysis; Core Computational Systems; Reactor Physics; Monte Carlo; Safety Aspects of Heavy Water Reactors; and Space-Time Core Kinetics. The individual reports have been cataloged separately. (FI)

Risk analysis and safety rationale

International Nuclear Information System (INIS)

Bengtsson, G.

1989-01-01

Decision making with respect to safety is becoming more and more complex. The risk involved must be taken into account together with numerous other factors such as the benefits, the uncertainties and the public perception. Can the decision maker be aided by some kind of system, general rules of thumb, or broader perspective on similar decisions? This question has been addressed in a joint Nordic project relating to nuclear power. Modern techniques for risk assessment and management have been studied, and parallels drawn to such areas as offshore safety and management of toxic chemicals in the environment. The report summarises the finding of 5 major technical reports which have been published in the NORD-series. The topics includes developments, uncertainties and limitations in probabilistic safety assessments, negligible risks, risk-cost trade-offs, optimisation of nuclear safety and radiation protection, and the role of risks in the decision making process. (author) 84 refs

ELA-max: A new topical lidocaine formulation.

Science.gov (United States)

Goldman, Ran D

2004-05-01

To evaluate the role of a new formulation of lidocaine (ELA-max) in local anesthesia in children and compare it with the eutectic mixture of local anesthetics (EMLA). Relevant literature was identified by a MEDLINE search (1966-November 2003) using the search terms ELA-max and EMLA. Bibliographies of selected articles were also examined to include all relevant investigations. The product manufacturer was contacted for inclusion of the most recent data available. Topical anesthesia in children is clinically challenging. ELA-max has been shown to be as effective as EMLA for venipuncture in children, but with faster onset. Adverse effects, such as transient blanching with redness and erythema, have been reported. Further investigation is needed to determine the effectiveness of ELA-max on other painful procedures in children, as well as its safety.

Summertime Health and Safety

Centers for Disease Control (CDC) Podcasts

This CDC series features topics on staying safe and healthy during the summer, whether on the road or on the water. Podcasts provide tips for general audiences on avoiding water-related injuries, driving safely, safety when outdoors, and celebrating safety on the 4th of July.

Aviation Safety Program: Weather Accident Prevention (WxAP) Project Overview and Status

Science.gov (United States)

Nadell, Shari-Beth

2003-01-01

This paper presents a project overview and status for the Weather Accident Prevention (WxAP) aviation safety program. The topics include: 1) Weather Accident Prevention Project Background/History; 2) Project Modifications; 3) Project Accomplishments; and 4) Project's Next Steps.

The safety of nuclear power: Strategy for the future

International Nuclear Information System (INIS)

1992-01-01

The conference took place in Vienna from 2 to 6 September 1991. It was attended by approximately 350 participants from about fifty countries and 12 international organizations. The conference was directed to decision makers on nuclear safety and energy policy at the technical policy level. Its objective was to review the nuclear power safety issues on which international consensus would be desirable, to address the concerns on nuclear safety expressed by the WCED, and to formulate recommendations for future actions by national and international authorities to advance nuclear safety to the highest level, including proposals for the IAEA's future activities for consideration by its governing bodies. Background Papers were prepared in advance of the conference by Expert Groups on the following five issues: Fundamental principles for the safe use of nuclear power; Ensuring and enhancing safety of operating plants; Treatment of nuclear power plants built to earlier safety standards; The next generation of nuclear power plants; Final disposal of radioactive waste. On the basis of comments received on these papers from IAEA Member States, significant topics for discussion were identified. These topics and the papers formed the basis of the discussions from which the conference arrived at recommendations for future action by national and international authorities. A separate abstract was prepared for the opening speeches, background papers, major findings of the conference and the President's closing statement. 2 figs, 1 tab

HTR-PM Safety requirement and Licensing experience

International Nuclear Information System (INIS)

Li Fu; Zhang Zuoyi; Dong Yujie; Wu Zongxin; Sun Yuliang

2014-01-01

HTR-PM is a 200MWe modular pebble bed high temperature reactor demonstration plant which is being built in Shidao Bay, Weihai, Shandong, China. The main design parameters of HTR-PM were fixed in 2006, the basic design was completed in 2008. The review of Preliminary Safety Analysis Report (PSAR) of HTR-PM was started in April 2008, completed in September 2009. In general, HTR- PM design complies with the current safety requirement for nuclear power plant in China, no special standards are developed for modular HTR. Anyway, Chinese Nuclear Safety Authority, together with the designers, developed some dedicated design criteria for key systems and components and published the guideline for the review of safety analysis report of HTR-PM, based on the experiences from licensing of HTR-10 and new development of nuclear safety. The probabilistic safety goal for HTR-PM was also defined by the safety authority. The review of HTR-PM PSAR lasted for one and a half years, with 3 dialogues meetings and 8 topics meetings, with more than 2000 worksheets and answer sheets. The heavily discussed topics during the PSAR review process included: the requirement for the sub-atmospheric ventilation system, the utilization of PSA in design process, the scope of beyond design basis accidents, the requirement for the qualification of TRISO coating particle fuel, and etc. Because of the characteristics of first of a kind for the demonstration plant, the safety authority emphasized the requirement for the experiment and validation, the PSAR was licensed with certain licensing conditions. The whole licensing process was under control, and was re-evaluated again after Fukushima accident to be shown that the design of HTR-PM complies with current safety requirement. This is a good example for how to license a new reactor. (author)

A research framework of organizational factors on safety in the Republic of Korea

International Nuclear Information System (INIS)

Kwang Seok Lee

1997-01-01

Korean nuclear society is yet unfamiliar with the topic, 'organizational factors on safety', while having shown lots of accomplishments in the area of physical and human factors on safety. However, recent large-scale accidents in other technological areas illustrate the importance of managing organization factors on safety. Recently Korea Atomic Energy Research Institute (KAERI) started paying attention to this topic and is trying to establish a future research framework of organizational factors on safety. This paper tries to explain overall direction of the framework. Our framework, as managing organizational factors on safety, considers two kinds of areas: design of management systems, which implies a feed-forward system including organizational models; and operation of those systems, which implies a feedback system including management information and implementation systems. Our framework also considers the evolution stage of a management system. Management systems evolve from visibility stage to optimization stage. To optimize a management system, we should be able to control the system. To control the system, we should be able to see how the system is going. In addition, this paper tries to share some experience of KAERI on how organizational structure and culture affects organizational performance in R and D perspective. (author). 2 refs, 1 fig

The safety of Ontario's nuclear reactors

International Nuclear Information System (INIS)

1980-06-01

A Select Committee of the Legislature of Ontario was established to examine the affairs of Ontario Hydro, the provincial electrical utility. Extensive public hearings were held on several topics including the safety of nuclear power reactors operating in Ontario. The Committee found that these reactors are acceptably safe. Many of the 24 recommendations in this report deal with the licensing process and public access to information. (O.T.)

Topical ganciclovir in the treatment of acute herpetic keratitis

Directory of Open Access Journals (Sweden)

Khalid F Tabbara

2010-08-01

Full Text Available Khalid F Tabbara1,2,3, Noorjehan Al Balushi11The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, 2Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia; 3The Wilmer Ophthalmological Institute of The Johns Hopkins University School of Medicine, Baltimore, Maryland, USAAbstract: Herpetic keratitis is caused by herpes simplex virus (HSV and is a common cause of corneal blindness. Following a primary ocular herpetic infection, latency of the virus occurs, followed by subsequent recurrences of herpetic keratitis. Such recurrences may lead to structural damage of the cornea. Recurrent herpetic keratitis is a common indication for corneal transplantation. Recurrences of herpetic keratitis in the corneal graft may lead to corneal graft rejection. Several antiviral agents for HSV are available, including the thymidine analogs. Prolonged use of thymidine analogs may lead to toxicity of the ocular surface, including epithelial keratitis, corneal ulcers, follicular conjunctivitis, and punctal occlusions. Availability of topical antiviral agents that are safe and effective in the treatment and prophylaxis of herpetic keratitis is highly desirable. Ganciclovir is a potent inhibitor of members of the herpes virus family. The drug has been used systemically for the treatment of cytomegalovirus (CMV retinitis. Its hematologic toxicity secondary to systemic administration led to its limited use in herpetic infections. On the other hand, topical ganciclovir has been shown to be as safe and effective as acyclovir in the treatment of herpetic epithelial keratitis. Furthermore, topical ganciclovir can reach therapeutic levels in the cornea and aqueous humor following topical application. Several clinical trials have shown that topical ganciclovir 0.15% ophthalmic gel is safe and effective in the treatment and prophylaxis of herpetic epithelial disease. Long-term use of ganciclovir ophthalmic

Regulatory oversight report 2007 concerning nuclear safety in Swiss nuclear installations

International Nuclear Information System (INIS)

2008-04-01

This annual report issued by the Swiss Federal Nuclear Inspectorate (HSK) reports on the work carried out by the Inspectorate in 2007. This report reviews the regulatory activities in the four Swiss nuclear power stations and in four further nuclear installations in various Swiss research facilities. It deals with topics such as operational details, technologies in use, radiation protection, radioactive wastes, emergency dispositions and personnel and provides an assessment of operations from the point of view of safety. Also, the transportation of nuclear materials - both nuclear fuels and nuclear wastes - is reported on. General topics discussed include probabilistic safety analyses and accident management. Finally, the disposal of nuclear wastes and work done in the rock laboratories in Switzerland is commented on

Atopic dermatitis: tacrolimus vs. topical corticosteroid use | Langa ...

African Journals Online (AJOL)

Despite this, the US Food and Drug Administration (FDA) black box warning of possible malignancies has resulted in much debate among experts. The main focus of this article is to compare the safety and efficacy of topical corticosteroids to calcineurin inhibitors, particularly tacrolimus. Furthermore, the aim is to evaluate ...

A review of three stand-alone topical thrombins for surgical hemostasis.

Science.gov (United States)

Cheng, Christine M; Meyer-Massetti, Carla; Kayser, Steven R

2009-01-01

Topical thrombins are active hemostatic agents that can be used to minimize blood loss during surgery. Before 2007, the only topical thrombins available were derived from bovine plasma. Antibody formation to bovine thrombin and/or factor V, with subsequent risk of cross-reactivity with human factor V, and hemorrhagic complications associated with human factor-V deficiencies have been described in case reports of surgeries in which bovine thrombins were used. This risk is now included in the boxed warning section of the bovine thrombin prescribing information. In 2007 and 2008, 2 new topical thrombins from nonbovine sources received approval for use from the US Food and Drug Administration. The 3 active topical thrombins that are currently marketed are bovine plasma-derived thrombin, human plasma-derived thrombin, and human recombinant thrombin. The purpose of this review was to evaluate the literature on the efficacy and safety of topical thrombins and discuss the pharmacoeconomic considerations associated with their use. PubMed, EMBASE, and International Pharmaceutical Abstracts were searched for relevant papers published in English through October 10,2008, using the terms thrombin, human recombinant thrombin, bovine thrombin, plasma derived thrombin, and topical thrombin. Manufacturer-provided materials were also reviewed. Abstracts and unpublished data, as well as evaluations of sealants, adhesives, glues, and other hemostats that contain thrombin mixed with fibrinogen and other clotting factors, were excluded. Four randomized, double-blind studies involving the active, stand-alone topical thrombins were found. The bovine thrombin involved in these studies was the predecessor to the currently marketed, highly purified bovine formulation. No studies comparing the human products, studies involving the highly purified bovine preparation, or placebo-controlled studies involving bovine thrombin were found. In a Phase III comparison of human recombinant thrombin and

Systematic evaluation program review of NRC Safety Topic VI-7.3 associated with the electrical, instrumentation and control portions of the ECCS actuation system for the Dresden II Nuclear Power Plant

International Nuclear Information System (INIS)

St Leger-Barter, G.

1980-11-01

This report documents the technical evaluation and review of NRC Safety Topic VI-7.A.3, associated with the electrical, instrumentation, and control portions of the classification of the ECCS actuation system for the Dresden II nuclear power plant, using current licensing criteria

System and safety studies of accelerator driven transmutation systems

Energy Technology Data Exchange (ETDEWEB)

Gudowski, W.; Wallenius, J.; Tucek, K.; Eriksson, Marcus; Carlsson, Johan; Seltborg, P.; Cetnar, J. [Royal Inst. of Technology, Stockholm (Sweden). Dept. of Nuclear and Reactor Physics

2001-05-01

The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the department has been focused on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache). Moreover, during the reporting period the EU-project 'IABAT', co-ordinated by the department has been finished and 4 other projects have been initiated in the frame of the 5th European Framework Programme. Most of the research topics reported in this paper are referred to appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details.

System and safety studies of accelerator driven transmutation systems

International Nuclear Information System (INIS)

Gudowski, W.; Wallenius, J.; Tucek, K.; Eriksson, Marcus; Carlsson, Johan; Seltborg, P.; Cetnar, J.

2001-05-01

The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the department has been focused on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache). Moreover, during the reporting period the EU-project 'IABAT', co-ordinated by the department has been finished and 4 other projects have been initiated in the frame of the 5th European Framework Programme. Most of the research topics reported in this paper are referred to appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details

Topical nonsteroidal anti-inflammatory drugs for management of osteoarthritis in long-term care patients

Directory of Open Access Journals (Sweden)

Argoff CE

2011-09-01

Full Text Available Charles E Argoff1, F Michael Gloth2 1Albany Medical College and Comprehensive Pain Center, Albany Medical Center, Albany, NY, USA; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA Abstract: Osteoarthritis is common in patients ≥65 years of age. Although nonsteroidal anti-inflammatory drugs (NSAIDs are often prescribed for osteoarthritis pain, they pose age-related cardiovascular, renal, and gastrointestinal risks. Two topical NSAIDs, diclofenac sodium 1% gel (DSG and diclofenac sodium 1.5% in 45.5% dimethylsulfoxide solution (D-DMSO, are approved in the US for the treatment of osteoarthritis pain. Topical NSAIDs have shown efficacy and safety in knee (DSG, D-DMSO and hand (DSG osteoarthritis. Analyses of data from randomized controlled trials of DSG in hand and knee osteoarthritis demonstrate significant improvement of pain and function in both younger patients (<65 years and older patients (≥65 years and suggest good safety and tolerability. However, long-term safety data in older patients are limited. Topical NSAIDs can ease medication administration and help address barriers to pain management in older patients, such as taking multiple medications and inability to swallow, and are a valuable option for long-term care providers. Keywords: nonsteroidal anti-inflammatory drugs, long-term care, nursing homes, chronic pain, topical analgesics

Diclofenac epolamine topical patch relieves pain associated with ankle sprain

Directory of Open Access Journals (Sweden)

David R Lionberger

2011-03-01

Full Text Available David R Lionberger1, Eric Joussellin2, Arturo Lanzarotti3, Jillmarie Yanchick4, Merrell Magelli5 1Southwest Orthopedic Group, LLP, Houston, Texas, USA; 2Institut National du Sport, Paris, France; 3Institut Biochimique SA, Pambionoranco, Switzerland; 4Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals®, Inc, Piscataway, New Jersey, USA; 5GTx, Inc, Memphis, Tennessee, USABackground: Sports-related injuries, such as sprains and strains, commonly occur during exercise and athletic events. Current therapy includes nonsteroidal anti-inflammatory drugs (NSAIDs, which have a high incidence of upper gastrointestinal side effects. The present study assessed the efficacy and safety of the diclofenac epolamine topical patch (DETP, 1.3%, a topical NSAID for the treatment of acute minor sprains and strains.Methods: This multicenter, randomized, placebo-controlled clinical study enrolled adult patients (n = 134 with acute ankle pain (due to a minor sprain occurring less than 48 hours prior to entering the study. Patients were treated with either the DETP or a placebo topical patch daily for seven days. Pain intensity was evaluated during the first six hours after application of the patch, and on treatment days 1, 2, 3, and 7.Results: Patients treated with the DETP experienced a significantly greater reduction in pain associated with their ankle injury compared with placebo, beginning four hours after the first patch application (P = 0.02. The DETP was well tolerated and was comparable with placebo in terms of safety.Conclusion: Overall, the results of this study demonstrate that the DETP is an effective analgesic for local treatment of pain in mild acute ankle sprain.Keywords: soft tissue injury, acute pain, visual analog scale, efficacy, tolerability 

The use of compound topical anesthetics: a review.

Science.gov (United States)

Kravitz, Neal D

2007-10-01

The author reviewed the history of, federal regulations regarding, risks of and adverse drug reactions of five compound topical anesthetics: tetracaine, adrenaline/epinephrine and cocaine (TAC); lidocaine, adrenaline/epinephrine and tetracaine (LET); lidocaine, tetracaine and phenylephrine (TAC 20 percent Alternate); lidocaine, prilocaine and tetracaine (Profound); and lidocaine, prilocaine, tetracaine and phenylephrine with thickeners (Profound PET). The author reviewed clinical trials, case reports, descriptive articles, and U.S. Food and Drug Administration (FDA) regulations and recent public advisory warnings regarding the federal approval of and risks associated with the use of compound topical anesthetics. Compound topical anesthetics are neither FDA-regulated nor -unregulated. Some compounding pharmacies bypass the new FDA drug approval process, which is based on reliable scientific data and ensures that a marketed drug is safe, effective, properly manufactured and accurately labeled. Two deaths have been attributed to the lay use of compound topical anesthetics. In response, the FDA has announced the strengthening of its efforts against unapproved drug products. Compound topical anesthetics may be an effective alternative to local infiltration for some minimally invasive dental procedures; however, legitimate concerns exist in regard to their safety. Until they become federally regulated, compound topical anesthetics remain unapproved drug products whose benefits may not outweigh their risks for dental patients.

Alberta Environment's weir safety program : options for rehabilitation to improve public safety : a case study of the Calgary weir

Energy Technology Data Exchange (ETDEWEB)

Blakely, D [Alberta Environment, Edmonton, AB (Canada)

2009-07-01

Alberta Environment Water Management Operations (WMO) owns and operates 46 dams and 800 kilometres of canals in Alberta. The WMO consists of 120 staff and several contract operators to take care of this infrastructure. Most of the infrastructure supplies water for irrigation use, which adds 5 billion dollars to the provincial economy annually. Other water uses include stock watering, domestic use, municipal use, recreational use and habitat. Alberta Environment's weir safety program was also discussed along with options for rehabilitation to improve public safety. A case study of Calgary's Weir Dam on the Bow River was highlighted. A brief history of the dam was offered and safety programs around provincially-owned weirs were discussed. Photographs were included to illustrate some of the additional safety measures at the Calgary weir, such as suspended safety buoys upstream of the boom directing paddlers to the portage trail, and signage on the river that can be activated when the boom is out. Typical river users on the Calgary Bow River and safety history at the Calgary Weir were discussed along with other topics such as the Calgary Bow River weir project criteria; project design progress; pre-feasibility options; scale modelling; final design analysis; construction funding; and proposed changes to the safety program for the new weir configuration. figs.

System Design and the Safety Basis

International Nuclear Information System (INIS)

Ellingson, Darrel

2008-01-01

The objective of this paper is to present the Bechtel Jacobs Company, LLC (BJC) Lessons Learned for system design as it relates to safety basis documentation. BJC has had to reconcile incomplete or outdated system description information with current facility safety basis for a number of situations in recent months. This paper has relevance in multiple topical areas including documented safety analysis, decontamination and decommissioning (D and D), safety basis (SB) implementation, safety and design integration, potential inadequacy of the safety analysis (PISA), technical safety requirements (TSR), and unreviewed safety questions. BJC learned that nuclear safety compliance relies on adequate and well documented system design information. A number of PIS As and TSR violations occurred due to inadequate or erroneous system design information. As a corrective action, BJC assessed the occurrences caused by systems design-safety basis interface problems. Safety systems reviewed included the Molten Salt Reactor Experiment (MSRE) Fluorination System, K-1065 fire alarm system, and the K-25 Radiation Criticality Accident Alarm System. The conclusion was that an inadequate knowledge of system design could result in continuous non-compliance issues relating to nuclear safety. This was especially true with older facilities that lacked current as-built drawings coupled with the loss of 'historical knowledge' as personnel retired or moved on in their careers. Walkdown of systems and the updating of drawings are imperative for nuclear safety compliance. System design integration with safety basis has relevance in the Department of Energy (DOE) complex. This paper presents the BJC Lessons Learned in this area. It will be of benefit to DOE contractors that manage and operate an aging population of nuclear facilities

Specialized meeting on 'Current topics of reactor safety research in Germany'; Fachtag 'Aktuelle Themen der Reaktorsicherheitsforschung in Deutschland'

Energy Technology Data Exchange (ETDEWEB)

Kruessenberg, Anne

2013-04-15

On October 11 and 12, 2012, the 2-day specialized meeting organized by the Thermodynamics and Fluid Dynamics Group together with the Dresden-Rossendorf Helmholtz Center and TUeV NORD SysTec GmbH and Co.KG was held at the Dresden-Rossendorf Helmholtz Center within the series of events on 'Current Topics of Safety Research in Germany.' The program of lectures was supplemented by poster presentations and exhibitions by the members of the joint research groups and companies working in the fields. The meeting again was very well attended by over 100 persons. (orig.)

Management of National Nuclear Power Programs for assured safety

Energy Technology Data Exchange (ETDEWEB)

Connolly, T.J. (ed.)

1985-01-01

Topics discussed in this report include: nuclear utility organization; before the Florida Public Service Commission in re: St. Lucie Unit No. 2 cost recovery; nuclear reliability improvement and safety operations; nuclear utility management; training of nuclear facility personnel; US experience in key areas of nuclear safety; the US Nuclear Regulatory Commission - function and process; regulatory considerations of the risk of nuclear power plants; overview of the processes of reliability and risk management; management significance of risk analysis; international and domestic institutional issues for peaceful nuclear uses; the role of the Institute of Nuclear Power Operations (INPO); and nuclear safety activities of the International Atomic Energy Agency (IAEA).

Management of National Nuclear Power Programs for assured safety

International Nuclear Information System (INIS)

Connolly, T.J.

1985-01-01

Topics discussed in this report include: nuclear utility organization; before the Florida Public Service Commission in re: St. Lucie Unit No. 2 cost recovery; nuclear reliability improvement and safety operations; nuclear utility management; training of nuclear facility personnel; US experience in key areas of nuclear safety; the US Nuclear Regulatory Commission - function and process; regulatory considerations of the risk of nuclear power plants; overview of the processes of reliability and risk management; management significance of risk analysis; international and domestic institutional issues for peaceful nuclear uses; the role of the Institute of Nuclear Power Operations (INPO); and nuclear safety activities of the International Atomic Energy Agency (IAEA)

Using resources for scientific-driven pharmacovigilance: from many product safety documents to one product safety master file.

Science.gov (United States)

Furlan, Giovanni

2012-08-01

Current regulations require a description of the overall safety profile or the specific risks of a drug in multiple documents such as the Periodic and Development Safety Update Reports, Risk Management Plans (RMPs) and Signal Detection Reports. In a resource-constrained world, the need for preparing multiple documents reporting the same information results in shifting the focus from a thorough scientific and medical evaluation of the available data to maintaining compliance with regulatory timelines. Since the aim of drug safety is to understand and characterize product issues to take adequate risk minimization measures rather than to comply with bureaucratic requirements, there is the need to avoid redundancy. In order to identify core drug safety activities that need to be undertaken to protect patient safety and reduce the number of documents reporting the results of these activities, the author has reviewed the main topics included in the drug safety guidelines and templates. The topics and sources that need to be taken into account in the main regulatory documents have been found to greatly overlap and, in the future, as a result of the new Periodic Safety Update Report structure and requirements, in the author's opinion this overlap is likely to further increase. Many of the identified inter-document differences seemed to be substantially formal. The Development Safety Update Report, for example, requires separate presentation of the safety issues emerging from different sources followed by an overall evaluation of each safety issue. The RMP, instead, requires a detailed description of the safety issues without separate presentation of the evidence derived from each source. To some extent, however, the individual documents require an in-depth analysis of different aspects; the RMP, for example, requires an epidemiological description of the indication for which the drug is used and its risks. At the time of writing this article, this is not specifically

Systemic and Topical Use of Tranexamic Acid in Spinal Surgery: A Systematic Review

Science.gov (United States)

Winter, Sebastian F.; Santaguida, Carlo; Wong, Jean; Fehlings, Michael G.

2015-01-01

Study Design Combination of narrative and systematic literature reviews. Objectives Massive perioperative blood loss in complex spinal surgery often requires blood transfusions and can negatively affect patient outcome. Systemic use of the antifibrinolytic agent tranexamic acid (TXA) has become widely used in the management of surgical bleeding. We review the clinical evidence for the use of intravenous TXA as a hemostatic agent in spinal surgery and discuss the emerging role for its complementary use as a topical agent to reduce perioperative blood loss from the surgical site. Through a systematic review of published and ongoing investigations on topical TXA for spinal surgery, we wish to make spine practitioners aware of this option and to suggest opportunities for further investigation in the field. Methods A narrative review of systemic TXA in spinal surgery and topical TXA in surgery was conducted. Furthermore, a systematic search (using PRISMA guidelines) of PubMed (MEDLINE), EMBASE, and Cochrane CENTRAL databases as well as World Health Organization International Clinical Trials Registry Platform, ClinicalTrials.gov (National Institutes of Health), and International Standard Randomized Controlled Trial Number registries was conducted to identify both published literature and ongoing clinical trials on topical TXA in spinal surgery. Results Of 1,631 preliminary search results, 2 published studies were included in the systematic review. Out of 285 ongoing clinical trials matching the search criteria, a total of 4 relevant studies were included and reviewed. Conclusion Intravenous TXA is established as an efficacious hemostatic agent in spinal surgery. Use of topical TXA in surgery suggests similar hemostatic efficacy and potentially improved safety as compared with intravenous TXA. For spinal surgery, the literature on topical TXA is sparse but promising, warranting further clinical investigation and consideration as a clinical option in cases with

The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis.

Science.gov (United States)

Chen, Shubiao; Wu, Kezhou; Kong, Gengbin; Feng, Weili; Deng, Zhihua; Wang, Hu

2016-02-16

Topical tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after total knee arthroplasty. However, the effectiveness of topical TXA use in total hip arthroplasty (THA) still remains unclear. The purpose of this meta-analysis is to examine the safety and efficacy of topical use of TXA following THA. Topical TXA reduces blood loss and transfusion rates without increasing risk of deep vein thrombosis in patients with THA. An electronic literature search of PubMed, Embase, the Cochrane Library, Web of Science and Chinese Biomedical Database was performed, to identify studies published before February 2015. All randomized controlled trials and cohort studies evaluating the efficacy of topical TXA during THA were included. Two independent authors identified the eligible studies, assessed their methodological quality, and extracted data. The data were using fixed-effects or random-effects models with (standard) mean differences and risk ratios for continuous and dichotomous variables, respectively. Data were analysed using RevMan 5.3 software. Fourteen studies encompassing 2594 patients met the inclusion criteria for our meta-analysis. Our meta-analysis indicated that when compared with the placebo group, topical use of TXA significantly reduced total blood loss (MD = -297.65 ml, 95 % CI -371.68 ml, 116.08 ml; P level (SMD = -0.66, 95 % CI -0.91, -0.41; P Topical TXA could significantly reduce total blood loss, drainage loss, transfusion rates and decrease haemoglobin level following THA, without increasing risk of venous thromboembolisms.

Safety-related topics from the Nuclear Power Options Viability Study

International Nuclear Information System (INIS)

Trauger, D.B.; White, J.D.

1986-01-01

The Nuclear Power Options Viability Study (NPOVS) evaluated innovative reactor concepts, and this article reviews NPOVS findings, with emphasis on safety and licensing. The reactors studied were of light-water, liquid-metal, and helium-cooled concepts, and most were of modular design. Prelicensed standard plants offer an important step toward regulatory stability and early licensing approvals with public participation before major expenditures. Advanced reactors with passive safety features offer the possibility of performance-based regulation. The concepts studied appear to be potentially viable, but more complete designs will be required before economic evaluations can be definitive

Safety strategy

International Nuclear Information System (INIS)

Schultheiss, G.F.

1980-01-01

The basis for safety strategy in nuclear industry and especially nuclear power plants is the prevention of radioactivity release inside or outside of the technical installation. Therefore either technical or administrative measures are combined to a general strategy concept. This introduction will explain in more detail the following topics: - basic principles of safety - lines of assurance (LOA) - defense in depth - deterministic and probabilistic methods. This presentation is seen as an introduction to the more detailed discussion following in this course, nevertheless some selected examples will be used to illustrate the aspects of safety strategy development although they might be repeated later on. (orig.)

Nuclear safety review for the year 2001

International Nuclear Information System (INIS)

2002-07-01

The Nuclear Safety Review for the Year 2001 reports on worldwide efforts to strengthen nuclear and radiation safety, including radioactive waste safety. It is in three parts. Part 1 describes those events in 2001 that have, or may have, significance for nuclear, radiation and waste safety worldwide. It includes developments such as new initiatives in international cooperation, events of safety significance and events that may be indicative of trends in safety. Part 2 describes some of the IAEA's efforts to strengthen international co-operation in nuclear, radiation and waste safety during 2001. It covers legally binding international agreements, non-binding safety standards, and provisions for the application of safety standards. This is done in a very brief manner, because these issues are addressed in more detail in the Agency's Annual Report for 2001. Part 3 presents a brief look ahead to some issues that are likely to be prominent in the coming year(s). The topics covered were selected by the IAEA Secretariat on the basis of trends observed in recent years, account being taken of planned or expected future developments. A draft of the Nuclear Safety Review for the Year 2001 was presented to the March 2002 session of IAEA's Board of Governors. This final version has been prepared taking account of the discussion in the Board. In some places, information has been added to describe developments early in 2002 that were considered pertinent to the discussion of events during 2001

Activities of the PNC Nuclear Safety Working Group

International Nuclear Information System (INIS)

Kato, W.Y.

1991-01-01

The Nuclear Safety Working Group of the Pacific Nuclear Council promotes nuclear safety cooperation among its members. Status of safety research, emergency planning, development of lists of technical experts, severe accident prevention and mitigation have been the topics of discussion in the NSWG. This paper reviews and compares the severe accident prevention and mitigation program activities in some of the areas of the Pacific Basin region based on papers presented at a special session organized by the NSWG at an ANS Topical Meeting as well as papers from other sources

DOE contractor radiation safety CBT [computer based training] course

International Nuclear Information System (INIS)

Gardner, P.R.

1986-01-01

Westinghouse Hanford Company developed a generic Radiation Worker safety CBT course for Department of Energy contractors. Task analysis concentrated on actual and potential tasks and included visits to fourteen different contractor sites. Team Design and Prototype verification formed the major portion of the development phase. Lesson entry was accomplished using the WISE author system from WICAT Systems, Inc. The course features graded task simulations for both Pretest and Final; fourteen Topics in five Lessons, each Topic keyed to ''Critical Acts'' and Questions in the Pretest and Final; Automatic, Intensive, and Manual modes of instruction available for each Lesson; Practical Problems and Sample Questions associated with each Topic; and provisions for local configuration in several areas. The course is deliverable on IBM PC compatible equipment. 2 refs

Safety campaigns. TIS Launches New Safety Information Campaign

CERN Multimedia

2001-01-01

Need to start a new installation and worried about safety aspects? Or are you newly responsible for safety matters in a CERN building? Perhaps you're simply interested in how to make the working environment safer for yourself and your colleagues. Whatever the case, a new information campaign launched by TIS this week can help. The most visible aspects of the new campaign will be posters distributed around the Laboratory treating a different subject each month. The Web site - http://safety.cern.ch/ - which provides all safety related information. But these are not the only aspects of the new campaign. Members of the TIS/GS group, whose contact details can be found on the safety web site, are available to give information and advice on a one-to-one basis at any time. The campaign's launch has been timed to coincide with European Safety Week, organized by the European Agency for Safety and Health at Work and the subject treated in the first posters is safety inspection. This particular topic only concerns thos...

Diphenylcyclopropenone in patients with alopecia areata. A critically appraised topic

NARCIS (Netherlands)

Kuin, R. A.; Spuls, P. I.; Limpens, J.; van Zuuren, E. J.

2015-01-01

To assess the efficacy and safety of topical diphenylcyclopropenone (DPCP) in patients with alopecia areata. Study selection, data extraction, risk of bias assessment and analyses were carried out independently by two authors. The quality of evidence was rated with Grading of Recommendations

Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspension

OpenAIRE

Gaynes, Bruce I; Onyekwuluje, Anne

2008-01-01

Bruce I Gaynes1,2, Anne Onyekwuluje11Departments of Ophthalmology and 2Pharmacology, Rush College of Medicine, Chicago, Illinois, USAAbstract: The removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in September 1999 from the US market spurred considerable interest in the general safety and effectiveness of topical ophthalmic NSAIDs for treatment of anterior segment inflammation. In late 1999 the use of topical ocular NSAIDs declined in the US as a result of inc...

Nuclear Power Options Viability Study. Volume 3. Nuclear discipline topics

Energy Technology Data Exchange (ETDEWEB)

Trauger, D B; White, J D; Bowers, H I; Braid, R B; Cantor, R A; Daniels, L; Davis, R M; Delene, J G; Gat, U; Hood, T C

1986-09-01

Innovative reactor concepts are described and evaluated in accordance with criteria established in the study. The reactors to be studied were chosen on the basis of three ground rules: (1) the potential for commercialization between 2000-2010, (2) economic competiveness with coal-fired plants, and (3) the degree of passive safety in the design. The concepts, classified by coolants, were light water reactors, liquid metal reactors, and high temperature reactors, and most were of modular design. All the concepts appear to be potentially viable in the time frame selected, but the information available is not adequate for a definitive evaluation of their economic competitiveness. This volume primarily reports in greater detail on several topics from the study. These are: Construction, Economics, Regulation, Safety and Economic Risk, Nuclear Waste Transportation and Disposal, and Market Acceptance. Although treated generically, the topics are presented in the context of the reactor concepts of the study.

Nuclear Power Options Viability Study. Volume 3. Nuclear discipline topics

International Nuclear Information System (INIS)

Trauger, D.B.; White, J.D.; Bowers, H.I.

1986-09-01

Innovative reactor concepts are described and evaluated in accordance with criteria established in the study. The reactors to be studied were chosen on the basis of three ground rules: (1) the potential for commercialization between 2000-2010, (2) economic competiveness with coal-fired plants, and (3) the degree of passive safety in the design. The concepts, classified by coolants, were light water reactors, liquid metal reactors, and high temperature reactors, and most were of modular design. All the concepts appear to be potentially viable in the time frame selected, but the information available is not adequate for a definitive evaluation of their economic competitiveness. This volume primarily reports in greater detail on several topics from the study. These are: Construction, Economics, Regulation, Safety and Economic Risk, Nuclear Waste Transportation and Disposal, and Market Acceptance. Although treated generically, the topics are presented in the context of the reactor concepts of the study

An interagency space nuclear propulsion safety policy for SEI - Issues and discussion

Science.gov (United States)

Marshall, A. C.; Sawyer, J. C., Jr.

1991-01-01

An interagency Nuclear Safety Policy Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative nuclear propulsion program to facilitate the implementation of mission planning and conceptual design studies. The NSPWG developed a top level policy to provide the guiding principles for the development and implementation of the nuclear propulsion safety program and the development of Safety Functional Requirements. In addition, the NSPWG reviewed safety issues for nuclear propulsion and recommended top level safety requirements and guidelines to address these issues. Safety topics include reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations. In this paper the emphasis is placed on the safety policy and the issues and considerations that are addressed by the NSPWG recommendations.

19th JANNAF Safety and Environmental Protection Subcommittee Meeting. Volume 1

Science.gov (United States)

Cocchiaro, J. E. (Editor); Becker, D. L. (Editor)

2002-01-01

This volume, the first of two volumes, is a compilation of 22 unclassified/unlimited technical papers presented at the 19th Joint Army-Navy-NASA-Air Force (JANNAF) Safety & Environmental Protection Subcommittee Meeting. The meeting was held 18-21 March 2002 at the Sheraton Colorado Springs Hotel, Colorado Springs, Colorado. Topics covered include green energetic materials and life cycle pollution prevention; space launch range safety; propellant/munitions demilitarization, recycling, and reuse: and environmental and occupational health aspects of propellants and energetic materials.

U.S. Food System Working Conditions as an Issue of Food Safety.

Science.gov (United States)

Clayton, Megan L; Smith, Katherine C; Pollack, Keshia M; Neff, Roni A; Rutkow, Lainie

2017-02-01

Food workers' health and hygiene are common pathways to foodborne disease outbreaks. Improving food system jobs is important to food safety because working conditions impact workers' health, hygiene, and safe food handling. Stakeholders from key industries have advanced working conditions as an issue of public safety in the United States. Yet, for the food industry, stakeholder engagement with this topic is seemingly limited. To understand this lack of action, we interviewed key informants from organizations recognized for their agenda-setting role on food-worker issues. Findings suggest that participants recognize the work standards/food safety connection, yet perceived barriers limit adoption of a food safety frame, including more pressing priorities (e.g., occupational safety); poor fit with organizational strategies and mission; and questionable utility, including potential negative consequences. Using these findings, we consider how public health advocates may connect food working conditions to food and public safety and elevate it to the public policy agenda.

Active-learning Strategies for Legal Topics and Substance Abuse in a Pharmacy Curriculum.

Science.gov (United States)

Steinhardt, Sarah J; Clark, John E; Kelly, William N; Hill, Angela M

2017-02-25

Objective. To implement active-learning strategies to engage students in learning, applying, and teaching legal and substance abuse topics. Design. Medication Safety course student groups created films on a National Patient Safety Goal (NPSG) using a movie genre and presented them in film festival format. Pharmacogenomics course student groups taught ethical, legal, and social implications (ELSI) topics through presentation of short stories about comic book characters with genetic mutations. Students in the Drugs of Abuse course composed and performed dances depicting the mechanism of action of a drug in an in-class rave dance format. Assessment. Course evaluations revealed student engagement with subject material and enjoyment of the creative applications, critical thinking, and collaborative aspects of the activities. Students performed well on examination questions and graded assignments. Conclusion. These active-learning strategies facilitated students' abilities to learn, apply, and teach material in medication safety, pharmacogenomics, and substance abuse courses.

Proceedings of the nuclear criticality technology safety project

Energy Technology Data Exchange (ETDEWEB)

Sanchez, R.G. [comp.

1997-06-01

This document contains summaries of the most of the papers presented at the 1994 Nuclear Criticality Technology Safety Project (NCTSP) meeting, which was held May 10 and 11 at Williamsburg, Va. The meeting was broken up into seven sessions, which covered the following topics: (1) Validation and Application of Calculations; (2) Relevant Experiments for Criticality Safety; (3) Experimental Facilities and Capabilities; (4) Rad-Waste and Weapons Disassembly; (5) Criticality Safety Software and Development; (6) Criticality Safety Studies at Universities; and (7) Training. The minutes and list of participants of the Critical Experiment Needs Identification Workgroup meeting, which was held on May 9 at the same venue, has been included as an appendix. A second appendix contains the names and addresses of all NCTSP meeting participants. Separate abstracts have been indexed to the database for contributions to this proceedings.

Proceedings of the nuclear criticality technology safety project

International Nuclear Information System (INIS)

Sanchez, R.G.

1997-06-01

This document contains summaries of the most of the papers presented at the 1994 Nuclear Criticality Technology Safety Project (NCTSP) meeting, which was held May 10 and 11 at Williamsburg, Va. The meeting was broken up into seven sessions, which covered the following topics: (1) Validation and Application of Calculations; (2) Relevant Experiments for Criticality Safety; (3) Experimental Facilities and Capabilities; (4) Rad-Waste and Weapons Disassembly; (5) Criticality Safety Software and Development; (6) Criticality Safety Studies at Universities; and (7) Training. The minutes and list of participants of the Critical Experiment Needs Identification Workgroup meeting, which was held on May 9 at the same venue, has been included as an appendix. A second appendix contains the names and addresses of all NCTSP meeting participants. Separate abstracts have been indexed to the database for contributions to this proceedings

Environment, safety and health

International Nuclear Information System (INIS)

Luzianovich, L.Ch.; Fardeau, J.C.; Darras, M.

2000-01-01

Environment, safety and health were the three topics discussed by the WOC 8 working group of the worldwide gas congress. Environment protection has become a major preoccupation and constraint for natural gas industry at the dawn of the new millennium. It is closely linked with the safety of installation and with the health of workmen who exploit or use natural gas energy: methane emissions, health and safety in gas industry, environment management and evaluation. (J.S.)

Nuclear Safety Project

International Nuclear Information System (INIS)

1983-12-01

The semiannual progress report 1983/1 is a description of work within the Nuclear Safety Project performed in the first six month of 1983 in the nuclear safety field by KfK institutes and departments and by external institutions on behalf of KfK. The chosen kind of this report is that of short summaries, containing the topics work performed, results obtained and plans for future work. (orig./RW) [de

Nuclear safety project

International Nuclear Information System (INIS)

Anon.

1980-11-01

The 17th semi-annual report 1980/1 is a description of work within the Nuclear Safety Project performed in the first six months of 1980 in the nuclear safety field by KfK institutes and departments and by external institutions on behalf of KfK. The chosen kind of this report is that of short summaries, containing the topics - work performed, results obtained, plans for future work. (orig.) [de

Seismic safety of nuclear power plants

International Nuclear Information System (INIS)

Guerpinar, A.; Godoy, A.

2001-01-01

This paper summarizes the work performed by the International Atomic Energy Agency in the areas of safety reviews and applied research in support of programmes for the assessment and enhancement of seismic safety in Eastern Europe and in particular WWER type nuclear power plants during the past seven years. Three major topics are discussed; engineering safety review services in relation to external events, technical guidelines for the assessment and upgrading of WWER type nuclear power plants, and the Coordinated Research Programme on 'Benchmark study for the seismic analysis and testing of WWER type nuclear power plants'. These topics are summarized in a way to provide an overview of the past and present safety situation in selected WWER type plants which are all located in Eastern European countries. Main conclusion of the paper is that although there is now a thorough understanding of the seismic safety issues in these operating nuclear power plants, the implementation of seismic upgrades to structures, systems and components are lagging behind, particularly for those cases in which the re-evaluation indicated the necessity to strengthen the safety related structures or install new safety systems. (author)

Definition and means of maintaining the supply ventilation system seismic shutdown portion of the PFP safety envelope. Revision 2

International Nuclear Information System (INIS)

Keck, R.D.

1995-01-01

This report describes the modifications to the ventilation system for the Plutonium Finishing Plant. Topics discussed in this report include; system functional requirements, evaluations of equipment, a list of drawings showing the safety envelope boundaries; list of safety envelope equipment, functional requirements for individual safety envelope equipment, and a list of the operational, maintenance and surveillance procedures necessary to operate and maintain the system equipment

TIS General Safety Group Annual Report 2000

CERN Document Server

Weingarten, W

2001-01-01

This report summarises the main activities of the General Safety (GS) Group of the Technical Inspection and Safety Division (TIS) during the year 2000, and the results obtained. The different topics in which the Group is active are covered: general safety inspections and ergonomy, electrical, chemistry and gas safety, chemical pollution containment and control, industrial hygiene, the safety of civil engineering works and outside contractors, fire prevention and the safety aspects of the LHC experiments.

Do Undergraduate Engineering Faculty Include Occupational and Public Health and Safety in the Engineering Curriculum?

Science.gov (United States)

Farwell, Dianna; And Others

1995-01-01

The purpose of this study was to determine whether and, if so, why engineering faculty include occupational and public health and safety in their undergraduate engineering courses. Data were collected from 157 undergraduate engineering faculty from 65 colleges of engineering in the United States. (LZ)

Photocarcinogenicity of selected topically applied dermatological drugs: calcineurin inhibitors, corticosteroids, and vitamin D analogs

Directory of Open Access Journals (Sweden)

Catharina Margrethe Lerche

2010-09-01

Full Text Available Topical therapies constitute the mainstay of dermatological treatments for skin disorders, such as atopic dermatitis, contact dermatitis, psoriasis, or acne. Since some of these diseases are often chronic, treatment duration may last for years and may even last the patient’s entire lifetime. Obviously, such long-term therapy may raise safety concerns, which also include the potential photocarcinogenic effect. Most patients are exposed to ultraviolet radiation (UVR during leisure, work, vacations, or in tanning beds. Additionally, the patients may receive UVR via UVB phototherapy or psoralens plus UVA radiation (PUVA. The use of immunosuppressant’s, such as corticosteroids and calcineurin inhibitors, has markedly increased. Patients with skin diseases have benefited from both systemic and topical treatment of both new and established drugs. The issue of a black box warning by the US Food and Drug Administration has increased concerns about photocarcinogenesis, which raises the question: “Are these drugs safe?” This review focuses on the mechanism of action and photocarcinogenic potential of commonly used topical treatments, such as corticosteroids, calcineurin inhibitors, and vitamin D analogs.

Patient safety: break the silence.

Science.gov (United States)

Johnson, Hope L; Kimsey, Diane

2012-05-01

A culture of patient safety requires commitment and full participation from all staff members. In 2008, results of a culture of patient safety survey conducted in the perioperative division of the Lehigh Valley Health Network in Pennsylvania revealed a lack of patient-centered focus, teamwork, and positive communication. As a result, perioperative leaders assembled a multidisciplinary team that designed a safety training program focusing on Crew Resource Management, TeamSTEPPS, and communication techniques. The team used video vignettes and an audience response system to engage learners and promote participation. Topics included using preprocedural briefings and postprocedural debriefings, conflict resolution, and assertiveness techniques. Postcourse evaluations showed that the majority of respondents believed they were better able to question the decisions or actions of someone with more authority. The facility has experienced a marked decrease in the number of incidents requiring a root cause analysis since the program was conducted. Copyright © 2012 AORN, Inc. Published by Elsevier Inc. All rights reserved.

Blood Loss and Transfusion After Topical Tranexamic Acid Administration in Primary Total Knee Arthroplasty.

Science.gov (United States)

Wang, Hao; Shen, Bin; Zeng, Yi

2015-11-01

There has been much debate and controversy about the safety and efficacy of the topical use of tranexamic acid in primary total knee arthroplasty (TKA). The purpose of this study was to perform a meta-analysis to evaluate whether there is less blood loss and lower rates of transfusion after topical tranexamic acid administration in primary TKA. A systematic review of the electronic databases PubMed, CENTRAL, Web of Science, and Embase was undertaken. All randomized, controlled trials and prospective cohort studies evaluating the effectiveness of topical tranexamic acid during primary TKA were included. The focus of the analysis was on the outcomes of blood loss results, transfusion rate, and thromboembolic complications. Subgroup analysis was performed when possible. Of 387 studies identified, 16 comprising 1421 patients (1481 knees) were eligible for data extraction and meta-analysis. This study indicated that when compared with the control group, topical application of tranexamic acid significantly reduced total drain output (mean difference, -227.20; 95% confidence interval, -347.11 to -107.30; Ptranexamic acid in primary TKA. Furthermore, the currently available evidence does not support an increased risk of deep venous thrombosis or pulmonary embolism due to tranexamic acid administration. Topical tranexamic acid was effective for reducing postoperative blood loss and transfusion requirements without increasing the prevalence of thromboembolic complications. Copyright 2015, SLACK Incorporated.

WHO guidance grounded in a comprehensive approach to sexual and reproductive health and human rights: topical pre-exposure prophylaxis.

Science.gov (United States)

Lusti-Narasimhan, Manjula; Khosla, Rajat; Baggaley, Rachel; Temmerman, Marleen; McGrory, Elizabeth; Farley, Tim

2014-01-01

Two new microbicide products based on topical (vaginal) application of antiretroviral drugs - 1% tenofovir gel and the dapivirine ring - are currently in late-stage clinical testing, and results on their safety and effectiveness are expected to become available in early 2015. WHO guidelines on the use of topical pre-exposure prophylaxis (topical PrEP) are important in order to ensure that these new prevention products are optimally used. Given that these new topical PrEP products are designed to be woman initiated and will likely be delivered in reproductive health settings, it is important to ensure that the guidance be framed in the context of comprehensive sexual and reproductive health and human rights. In addition to the safety and effectiveness data resulting from clinical trials, and the regulatory approval required for new products, the WHO normative guidelines on the use of topical PrEP will be essential for rapid roll-out in countries. Human rights standards and principles provide a framework for the provision of woman-initiated HIV prevention products. These include addressing issues related to the gender inequities which are linked to the provision of HIV-prevention, treatment and care for young girls and women. Effective programming for women and girls must therefore be based on understanding the local, social and community contexts of the AIDS epidemic in the country, and adapting HIV strategies and programmes accordingly. Such a framework therefore is needed not only to ensure optimal uptake of these new products by women and girls but also to address sociocultural barriers to women's and girls' access to these products.

ENS RRFM 2005: 9th international topical meeting on research reactor fuel management. Transactions

International Nuclear Information System (INIS)

2005-01-01

The ENS topical meeting on research reactor fuel management is an annual conference launched successfully in 1997. It has since then grown into well established international forum for the exchange and expertise on all significant aspects of the nuclear fuel cycle of research reactors. Oral presentations at this meeting were divided in the following four sessions: International Topics; Fuel Development, Qualification, Fabrication and Licensing; Reactor Operation, Fuel Safety and Core Conversion; Spent Fuel Management, Back-end Options, Transportation. The three poster sessions were devoted to fuel development, qualification, fabrication and licensing; reactor operation, fuel safety, core conversion, spent fuel; spent fuel management, fuel cycle back-end options, transportation

OSHA and Experimental Safety Design.

Science.gov (United States)

Sichak, Stephen, Jr.

1983-01-01

Suggests that a governmental agency, most likely Occupational Safety and Health Administration (OSHA) be considered in the safety design stage of any experiment. Focusing on OSHA's role, discusses such topics as occupational health hazards of toxic chemicals in laboratories, occupational exposure to benzene, and role/regulations of other agencies.…

Nuclear ships and their safety

Energy Technology Data Exchange (ETDEWEB)

NONE

1961-04-15

Several aspects of nuclear ship propulsion, with special reference to nuclear safety, were discussed at an international symposium at Taormina, Italy, from 14-18 November 1960. Discussions on specific topics are conducted, grouped under the following headings: Economics and National Activities in Nuclear Ship Propulsion; International Problems and General Aspects of Safety for Nuclear Ships; Nuclear Ship Projects from the Angle of Safety; Ship Reactor Problems; Sea Motion and Hull Problems; Maintenance and Refuelling Problems; and Safety Aspects of Nuclear Ship Operation.

Systems engineered health and safety criteria for safety analysis reports

International Nuclear Information System (INIS)

Beitel, G.A.; Morcos, N.

1993-01-01

The world of safety analysis is filled with ambiguous words: codes and standards, consequences and risks, hazard and accident, and health and safety. These words have been subject to disparate interpretations by safety analysis report (SAR) writers, readers, and users. open-quotes Principal health and safety criteriaclose quotes has been one of the most frequently misused phrases; rarely is it used consistently or effectively. This paper offers an easily understood definition for open-quotes principal health and safety criteriaclose quotes and uses systems engineering to convert an otherwise mysterious topic into the primary means of producing an integrated SAR. This paper is based on SARs being written for environmental restoration and waste management activities for the U.S. Department of Energy (DOE). Requirements for these SARs are prescribed in DOE Order 5480-23, open-quotes Nuclear Safety Analysis Reports.close quotes

Proceedings of the 8th topical meeting on nuclear code development

International Nuclear Information System (INIS)

1993-03-01

The 8th Topical Meeting on Nuclear Code Development, organized by Committee on Reactor Physics and Nuclear Codes Committee of Japan Atomic Energy Research Institute (JAERI), was held at Tokai Research Establishment of JAERI, on 11th and 12th of November, 1992. In the meeting, 14 papers were presented on the topics of (1) the next generation nuclear reactor design system and (2) advances of the nuclear fuel reprocessing safety analysis codes. These papers are compiled in this proceedings. (author)

Nuclear safety review for the year 2000

International Nuclear Information System (INIS)

2001-06-01

The nuclear safety review for the year 2000 reports on worldwide efforts to strengthen nuclear and radiation safety, including radioactive waste safety. It is in three parts: Part 1 describes those events in 2000 that have, or may have, significance for nuclear, radiation and waste safety worldwide. It includes developments such as new initiatives in international cooperation, events of safety significance and events that may be indicative of trends in safety; Part 2 describes some of the IAEA efforts to strengthen international co-operation in nuclear, radiation and waste safety during 2000. It covers legally binding international agreements, non-binding safety standards, and provisions for the application of safety standards. This is done in a very brief manner, because these issues are addressed in more detail in the Agency's Annual Report for 2000; Part 3 presents a brief look ahead to some issues that are likely to be prominent in the coming year(s). The topics covered were selected by the IAEA Secretariat on the basis of trends observed in recent years, account being taken of planned or expected future developments. A draft of the Nuclear Safety Review for the Year 2000 was presented to the March 2001 session of the IAEA Board of Governors. This final version has been prepared taking account of the discussion in the Board. In some places, information has been added to describe developments early in 2001 that were considered pertinent to the discussion of events during 2000. In such cases, a note containing the more recent information has been provided in the form of a footnote

Proceedings of the 1992 topical meeting on advances in reactor physics. Volume 2

Energy Technology Data Exchange (ETDEWEB)

1992-04-01

This document, Volume 2, presents proceedings of the 1992 Topical Meeting on Advances in Reactor Physics on March 8--11, 1992 at Charleston, SC. Session topics were as follows: Transport Theory; Fast Reactors; Plant Analyzers; Integral Experiments/Measurements & Analysis; Core Computational Systems; Reactor Physics; Monte Carlo; Safety Aspects of Heavy Water Reactors; and Space-Time Core Kinetics. The individual reports have been cataloged separately. (FI)

49 CFR 211.61 - Informal safety inquiries.

Science.gov (United States)

2010-10-01

... information on selected topics relating to railroad safety. A notice of each such inquiry will be published in... 49 Transportation 4 2010-10-01 2010-10-01 false Informal safety inquiries. 211.61 Section 211.61..., DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE Miscellaneous Safety-Related Proceedings and Inquiries § 211...

Tritium radioluminescent devices, Health and Safety Manual

Energy Technology Data Exchange (ETDEWEB)

Traub, R.J.; Jensen, G.A.

1995-06-01

This document consolidates available information on the properties of tritium, including its environmental chemistry, its health physics, and safe practices in using tritium-activated RL lighting. It also summarizes relevant government regulations on RL lighting. Chapters are divided into a single-column part, which provides an overview of the topic for readers simply requiring guidance on the safety of tritium RL lighting, and a dual-column part for readers requiring more technical and detailed information.

Tritium radioluminescent devices, Health and Safety Manual

International Nuclear Information System (INIS)

Traub, R.J.; Jensen, G.A.

1995-06-01

This document consolidates available information on the properties of tritium, including its environmental chemistry, its health physics, and safe practices in using tritium-activated RL lighting. It also summarizes relevant government regulations on RL lighting. Chapters are divided into a single-column part, which provides an overview of the topic for readers simply requiring guidance on the safety of tritium RL lighting, and a dual-column part for readers requiring more technical and detailed information

A 2-year study of patient safety competency assessment in 29 clinical laboratories.

Science.gov (United States)

Reed, Robyn C; Kim, Sara; Farquharson, Kara; Astion, Michael L

2008-06-01

Competency assessment is critical for laboratory operations and is mandated by the Clinical Laboratory Improvement Amendments of 1988. However, no previous reports describe methods for assessing competency in patient safety. We developed and implemented a Web-based tool to assess performance of 875 laboratory staff from 29 laboratories in patient safety. Question categories included workplace culture, categorizing error, prioritization of patient safety interventions, strength of specific interventions, and general patient safety concepts. The mean score was 85.0%, with individual scores ranging from 56% to 100% and scores by category from 81.3% to 88.6%. Of the most difficult questions (laboratory technologists. Computer-based competency assessments help laboratories identify topics for continuing education in patient safety.

Millwright Apprenticeship. Related Training Modules. 1.1-1.8 Safety.

Science.gov (United States)

Lane Community Coll., Eugene, OR.

This packet, part of the instructional materials for the Oregon apprenticeship program for millwright training, contains eight modules covering safety. The modules provide information on the following topics: general safety, hand tool safety, power tool safety, fire safety, hygiene, safety and electricity, types of fire and fire prevention, and…

System and safety studies of accelerator driven transmutation. Annual Report 2001

International Nuclear Information System (INIS)

Gudowski, W.; Wallenius, J.; Tucek, K.; Eriksson, Marcus; Carlsson, Johan; Seltborg, P.; Cetnar, J.; Chakarova, R.; Westlen, D.

2002-03-01

The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the Dept. of Nuclear and Reactor Physics has been focused in year 2001 on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics; c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache) and YALINA experiment in Minsk. The Dept. is very actively participating in many European projects in the 5th Framework Programme of the European Community. Most of the research topics reported in this paper are referred to by appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details

System and safety studies of accelerator driven transmutation. Annual Report 2001

Energy Technology Data Exchange (ETDEWEB)

Gudowski, W; Wallenius, J; Tucek, K; Eriksson, Marcus; Carlsson, Johan; Seltborg, P; Cetnar, J; Chakarova, R; Westlen, D [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Nuclear and Reactor Physics

2002-03-01

The research on safety of Accelerator-Driven Transmutation Systems (ADS) at the Dept. of Nuclear and Reactor Physics has been focused in year 2001 on: a) ADS core design and development of advanced nuclear fuel optimised for high transmutation rates and good safety features; b) analysis of ADS-dynamics; c) computer code and nuclear data development relevant for simulation and optimization of ADS; d) participation in ADS experiments including 1 MW spallation target manufacturing, subcritical experiments MUSE (CEA-Cadarache) and YALINA experiment in Minsk. The Dept. is very actively participating in many European projects in the 5th Framework Programme of the European Community. Most of the research topics reported in this paper are referred to by appendices, which have been published in the open literature. The topics, which are not yet published, are described here in more details.

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.

Science.gov (United States)

Blauvelt, Andrew; de Bruin-Weller, Marjolein; Gooderham, Melinda; Cather, Jennifer C; Weisman, Jamie; Pariser, David; Simpson, Eric L; Papp, Kim A; Hong, H Chih-Ho; Rubel, Diana; Foley, Peter; Prens, Errol; Griffiths, Christopher E M; Etoh, Takafumi; Pinto, Pedro Herranz; Pujol, Ramon M; Szepietowski, Jacek C; Ettler, Karel; Kemény, Lajos; Zhu, Xiaoping; Akinlade, Bolanle; Hultsch, Thomas; Mastey, Vera; Gadkari, Abhijit; Eckert, Laurent; Amin, Nikhil; Graham, Neil M H; Pirozzi, Gianluca; Stahl, Neil; Yancopoulos, George D; Shumel, Brad

2017-06-10

Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis. We aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-severe atopic dermatitis. In this 1-year, randomised, double-blinded, placebo-controlled, phase 3 study (LIBERTY AD CHRONOS), adults with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids were enrolled at 161 hospitals, clinics, and academic institutions in 14 countries in Europe, Asia-Pacific, and North America. Patients were randomly assigned (3:1:3) to subcutaneous dupilumab 300 mg once weekly (qw), dupilumab 300 mg every 2 weeks (q2w), or placebo via a central interactive voice/web response system, stratified by severity and global region. All three groups were given concomitant topical corticosteroids with or without topical calcineurin inhibitors where inadvisable for topical corticosteroids. Topical corticosteroids could be tapered, stopped, or restarted on the basis of disease activity. Coprimary endpoints were patients (%) achieving Investigator's Global Assessment (IGA) 0/1 and 2-point or higher improvement from baseline, and Eczema Area and Severity Index 75% improvement from baseline (EASI-75) at week 16. Week 16 efficacy and week 52 safety analyses included all randomised patients; week 52 efficacy included patients who completed treatment by US regulatory submission cutoff. This study is registered with ClinicalTrials.gov, NCT02260986. Between Oct 3, 2014

Desonide: a review of formulations, efficacy and safety.

Science.gov (United States)

Kahanek, Nr; Gelbard, Cg; Hebert, Aa

2008-07-01

Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses. The favorable safety profile of this topical agent makes it ideal for patients of all ages. This article provides a review of desonide's history, pharmacodynamic properties, vehicle technology, efficacy and safety. Randomized controlled trials, as well as open-label and non-comparative studies, case series and reports, experimental models, and data from the Galderma pharmacovigiliance program were reviewed in order to address the clinical efficacy and safety of desonide. Clinical efficacy and safety have been proven in multiple clinical trials. In addition to cream, lotion and ointment formulations, the recently developed hydrogel and foam preparations have increased desonide's versatility and patient tolerability.

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Safety Research. Annual report 2010

International Nuclear Information System (INIS)

Gerbeth, Gunter; Schaefer, Frank

2011-01-01

The Institute of Safety Research (ISR) was over the past 20 years one of the six Research Institutes of Forschungszentrum Dresden-Rossendorf e.V. (FZD), which in 2010 belonged to the Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz. Together with the Institutes of Radiochemistry and Radiation Physics, ISR implements the research programme ''Nuclear Safety Research'' (NSR), which was during last years one of the three scientific programmes of FZD. NSR involves two main topics, i.e. ''Safety Research for Radioactive Waste Disposal'' and ''Safety Research for Nuclear Reactors''. The research of ISR aims at assessing and enhancing the safety of current and future reactors, the development of advanced simulation tools including their validation against experimental data, and the development of the appropriate measuring techniques for multi-phase flows and liquid metals.

Some topics on radioecological research in marine environment

International Nuclear Information System (INIS)

Shimizu, Makoto

1993-01-01

In Japan, systematic researches on marine environmental radioactivity started in 1954 when 'Bikini incidence' occurred. After several years of handling emergency situations, basic studies were carried out to understand processes and mechanisms of contamination of aquatic organisms by radionuclides. At this period 'Hiyama Group' had a large contribution to the development of this new field of research. Important concepts and items have already been dealt with in this Grant Group. Toward the end of 'Hiyama Group', a new project started in Nuclear Safety Research Association. This project, so-called 'Kaihohtoku', aimed at gathering necessary information for safety assessment on the release of low-level radioactive liquid wastes from a newly planned spent-fuel reprocessing plant at Tokai. NIRS-Nakaminato Branch was established first as Marine Radioecological Station in this project. The term 'radioecology' got popularity also in this period. Many important results were obtained and scientific basis of the safety assessment was established in this project. Today we have not any urgent matter to be handled concerning radioecology in our coastal environment. Nuclides found are exclusively of fallout and of a quite low level. We have also established methodology of radiological assessment. So, what is the problem? The problem is 'from conservative to realistic', which is the trend in the world. Here, from this viewpoint, some topics such as models and parameters including concentration factors and their validation and verification in the natural environment were discussed. (author)

Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety

Institute of Scientific and Technical Information of China (English)

Xiao-hong MAO; Jian-you WANG; Jian-liang YAN

2012-01-01

Objective:To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients.Methods:A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders,including 19 infantile hemangiomas (IHs) (12 superficial/7 mixed type),5 nevus flammeus (NF),and 1 pyogenic granuloma (PG).Imiquimod 5％ cream was applied every other day for 4 to 16 weeks (average 9.6weeks).Results:Of the 19 IHs treated,an overall efficacy of 52.6％ was achieved,with a clinical resolution rate of 15.8％,excellent rate of 26.3％,and moderate rate of 10.5％.The superficial type responded the best at 66.7％,while the mixed type showed only 28.6％ effectiveness,which was predominantly from their superficial parts.No obvious response was noted in the 5 patients with NF.Side effects were observed in 78.9％ of the patients,mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration.Systemic side events were observed in 4 IH patients including fever and digestive tract reactions.No recurrence was observed during the follow-up examination.Conclusions:Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.

Study programme on safety for environmental radioactivity during the period from 1986 to 1990

International Nuclear Information System (INIS)

1986-01-01

The study programme is divided into four topics. The first topic is a study on environmental doses, which was designed to identify levels of radioactivity, and characteristics and behavior of radiation sources in the ambient air, and to elucidate population dose estimates. The second topic concerning biological effects of radiation focusses on the elucidation for mechanism whereby radiation acts on the living body, for effects of low dose radiation using experimental animals, and for radiation effects on the human body using epidemiological approaches. The aim of the third topic is to study incorporation of alpha radiators, including transuranic elements, and tritium in the human body. The last topic is the safety evaluation, for which it is required to establish methods of evaluating human risk of environmental radiation and to prepare data base. An outline of these topics is given. (Namekawa, K.)

Numerical simulation on the screw pinch by 2-D MHD pinch code 'topics' including impurities and neutrals effects

International Nuclear Information System (INIS)

Nagata, A.; Ashida, H.; Okamoto, M.; Hirano, K.

1981-03-01

Two dimentional fluid simulation code ''TOPICS'' is developed for the STP-2, the shock heated screw pinch at Nagoya. It involves the effects of impurity ions and neutral atoms. In order to estimate the radiation losses, the impurity continuity equations with ionizations and recombinations are solved simultaneously with the plasma fluid equations. The results are compared with the coronal equilibrium model. It is found that the coronal equilibrium model underestimates the radiation losses from shock heated pinch plasmas in its initial dynamic phase. The present calculations including impurities and neutrals show the importance of the radiation losses from the plasma of the STP-2. Introducing the anomalous resistivity caused by the ion acoustic instability, the observed magnetic field penetration is explained fairly well. (author)

Recent advances in systems safety and security

CERN Document Server

Stamatescu, Grigore

2016-01-01

This book represents a timely overview of advances in systems safety and security, based on selected, revised and extended contributions from the 2nd and 3rd editions of the International Workshop on Systems Safety and Security – IWSSS, held in 2014 and 2015, respectively, in Bucharest, Romania. It includes 14 chapters, co-authored by 34 researchers from 7 countries. The book provides an useful reference from both theoretical and applied perspectives in what concerns recent progress in this area of critical interest. Contributions, broadly grouped by core topic, address challenges related to information theoretic methods for assuring systems safety and security, cloud-based solutions, image processing approaches, distributed sensor networks and legal or risk analysis viewpoints. These are mostly accompanied by associated case studies providing additional practical value and underlying the broad relevance and impact of the field.

Twenty-third water reactor safety information meeting: Volume 1, plenary session, high burnup fuel behavior, thermal hydraulic research. Proceedings

Energy Technology Data Exchange (ETDEWEB)

Monteleone, S. [comp.] [Brookhaven National Lab., Upton, NY (United States)

1996-03-01

This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 1, present topics on High Burnup Fuel Behavior, Thermal Hydraulic Research, and Plenary Session topics. Individual papers have been cataloged separately.

Twenty-third water reactor safety information meeting: Volume 1, plenary session, high burnup fuel behavior, thermal hydraulic research. Proceedings

International Nuclear Information System (INIS)

Monteleone, S.

1996-03-01

This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 1, present topics on High Burnup Fuel Behavior, Thermal Hydraulic Research, and Plenary Session topics. Individual papers have been cataloged separately

Proceedings of the Topical Session of the 9. Meeting of the WPDD on 'Human and Organisational Factors in Decommissioning' Held at Harwell, United Kingdom on 7-8 November 2007

International Nuclear Information System (INIS)

NOYNAERT, Luc; O'SULLIVAN, Patrick

2008-01-01

At its eight meeting, the WPDD held a topical session on 'Human and Organisational Factors in Decommissioning'. This report documents the topical session. The main text summarises the main points from the presentations and discussions and includes the Rapporteur's report. Appendix 1 and 2 provide the agenda of the topical session and the list of attendees respectively. The topical session facilitated an exchange of information and experience on the following issues in particular: - Project management and contracting schemes being used for decommissioning projects and the benefits which may be gained from including former operational staff in decommissioning teams; - Planning and record keeping, including the extent to which inadequate historical records need be reconstructed; and - Approaches to workforce management, particularly in regard to safety. At the end of each session time was allotted for a plenary discussion. The Rapporteur reviewed the main points and the lessons learnt at the end of the Topical Session

Teaching the science of safety in US colleges and schools of pharmacy.

Science.gov (United States)

Holdford, David A; Warholak, Terri L; West-Strum, Donna; Bentley, John P; Malone, Daniel C; Murphy, John E

2011-05-10

This paper provides baseline information on integrating the science of safety into the professional degree curriculum at colleges and schools of pharmacy. A multi-method examination was conducted that included a literature review, key informant interviews of 30 individuals, and in-depth case studies of 5 colleges and schools of pharmacy. Educators believe that they are devoting adequate time to science of safety topics and doing a good job teaching students to identify, understand, report, manage, and communicate medication risk. Areas perceived to be in need of improvement include educating pharmacy students about the Food and Drug Administration's (FDA's) role in product safety, how to work with the FDA in post-marketing surveillance and other FDA safety initiatives, teaching students methods to improve safety, and educating students to practice in interprofessional teams. The report makes 10 recommendations to help pharmacy school graduates be more effective in protecting patients from preventable drug-related problems.

Topics and topic prominence in two sign languages

NARCIS (Netherlands)

Kimmelman, V.

2015-01-01

In this paper we describe topic marking in Russian Sign Language (RSL) and Sign Language of the Netherlands (NGT) and discuss whether these languages should be considered topic prominent. The formal markers of topics in RSL are sentence-initial position, a prosodic break following the topic, and

Application of fuzzy set theory for safety culture and safety management assessment of Kartini research reactor

International Nuclear Information System (INIS)

Syarip; Hauptmanns, U.

2000-01-01

The safety culture status of nuclear power plant is usually assessed through interview and/or discussions with personnel and management in plant, and an assessment of the pertinent documentation. The approach for safety culture assessment described in IAEA Safety Series, make uses of a questionnaire composed of questions which require 'Yes' or 'No' as an answer. Hence, it is basically a check-list approach which is quite common for safety assessments in industry. Such a procedure ignores the fact that the expert answering the question usually has knowledge which goes far beyond a mere binary answer. Additionally, many situations cannot readily be described in such restricted terms. Therefore, it was developed a checklist consisting of questions which are formulated such that they require more than a simple 'yes' or 'no' as an answer. This allows one to exploit the expert knowledge of the analyst appropriately by asking him to qualify the degree of compliance of each of the topics examined. The method presented has proved useful in assessing the safety culture and quality of safety management of the research reactor. The safety culture status and the quality of safety management of Kartini research reactor is rated as 'average'. The method is also flexible and allows one to add questions to existing areas or to introduce new areas covering related topics

Sixth ITER technical meeting on safety and environment

International Nuclear Information System (INIS)

Saji, G.; Baker, D.

1997-01-01

The article summarizes the topics of the Sixth Technical Meeting on Safety and Environment which was held to review the first draft of the Non-Site Specific Safety Report (NSSR-2) and the draft of the ITER Final Design Report Safety Assessment (FDR-Safety) during October 27 - November 4, 1997 at the ITER San Diego Joint Work Site

Aerodynamics of wind turbines emerging topics

CERN Document Server

Amano, R S

2014-01-01

Focusing on Aerodynamics of Wind Turbines with topics ranging from Fundamental to Application of horizontal axis wind turbines, this book presents advanced topics including: Basic Theory for Wind turbine Blade Aerodynamics, Computational Methods, and Special Structural Reinforcement Technique for Wind Turbine Blades.

Special Issue. 5th Meeting on Technology and Safety

International Nuclear Information System (INIS)

Kusakabe, Masashi; Kumagaya, Tadafusa; Minohara, Shinichi

2010-01-01

The documents in this Special Issue are the representative reports of achievements presented in the National Institute of Radiological Sciences (NIRS) 5th Meeting on Technology and Safety held on March 17, 2010. Personnel and investigators of NIRS and related companies gave their achievements by 19 oral and 31 poster presentations in fields of [IAR] irradiation (2 topics), accelerator/radiometry (9 topics), [EA] experimental animals (25 topics), [SM] safety management of facilities (5 topics), computer network system (4 topics), experimental instrument (1 topic), molecular imaging (2 topics) and others (2 topics). The Issue contains, as well as introductory and ending remarks, following 12 topics: [IAR] Working report of patient positioning system for radiotherapy with use of X-ray flat panel detector; Status of maintenance and management of facilities and equipments in Research center for Radiation Emergency Medicine; [EA] Past, present and future of mouse breeding in NIRS; Breeding of marmoset in NIRS/How can we have a bouncing marmoset baby?; Establishment of a genotyping method of transformed genes in transgenic mouse/genome walking method; Genetic monitoring system of mice by micro-satellite marker and its application in NIRS; Verification of sorting precision of FACSAria (Becton Dickinson and Co.), a highly sensitive, rapid sorting apparatus of cells/for precise sorting; Proposal of a task-solution workflow to determine the animal features for molecular imaging studies; [SM] Toward the introduction of Occupational Safety and Health Management System in NIRS; Use of unsealed radioisotopes less than the lower limit outside the legal control area; Arrangement of managing and supporting system for clinical studies; and Rearrangement of working system of personnel affairs. (T.T.)

Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures.

Science.gov (United States)

Ipema, Heather J; Tanzi, Maria G

2012-01-01

To evaluate the literature describing topical use of tranexamic acid or aminocaproic acid for prevention of postoperative bleeding after major surgical procedures. Literature was retrieved through MEDLINE (1946-September 2011) and International Pharmaceutical Abstracts (1970-September 2011) using the terms tranexamic acid, aminocaproic acid, antifibrinolytic, topical, and surgical. In addition, reference citations from publications identified were reviewed. All identified articles in English were evaluated. Clinical trials, case reports, and meta-analyses describing topical use of tranexamic acid or aminocaproic acid to prevent postoperative bleeding were included. A total of 16 publications in the setting of major surgical procedures were included; the majority of data were for tranexamic acid. For cardiac surgery, 4 trials used solutions containing tranexamic acid (1-2.5 g in 100-250 mL of 0.9% NaCl), and 1 trial assessed a solution containing aminocaproic acid (24 g in 250 mL of 0.9% NaCl). These solutions were poured into the chest cavity before sternotomy closure. For orthopedic procedures, all of the data were for topical irrigation solutions containing tranexamic acid (500 mg-3 g in 50-100 mL of 0.9% NaCl) or for intraarticular injections of tranexamic acid (250 mg to 2 g in 20-50 mL of 0.9% sodium chloride, with or without carbazochrome sodium sulfate). Overall, use of topical tranexamic acid or aminocaproic acid reduced postoperative blood loss; however, few studies reported a significant reduction in the number of packed red blood cell transfusions or units given, intensive care unit stay, or length of hospitalization. Topical application of tranexamic acid and aminocaproic acid to decrease postsurgical bleeding after major surgical procedures is a promising strategy. Further data are needed regarding the safety of this hemostatic approach.

Alberta Environment's weir safety program : options for rehabilitation to improve public safety : a case study of the Calgary weir

Energy Technology Data Exchange (ETDEWEB)

Blakely, D. [Alberta Environment, Edmonton, AB (Canada)

2009-07-01

Alberta Environment Water Management Operations (WMO) owns and operates 46 dams and 800 kilometres of canals in Alberta. The WMO consists of 120 staff and several contract operators to take care of this infrastructure. Most of the infrastructure supplies water for irrigation use, which adds 5 billion dollars to the provincial economy annually. Other water uses include stock watering, domestic use, municipal use, recreational use and habitat. Alberta Environment's weir safety program was also discussed along with options for rehabilitation to improve public safety. A case study of Calgary's Weir Dam on the Bow River was highlighted. A brief history of the dam was offered and safety programs around provincially-owned weirs were discussed. Photographs were included to illustrate some of the additional safety measures at the Calgary weir, such as suspended safety buoys upstream of the boom directing paddlers to the portage trail, and signage on the river that can be activated when the boom is out. Typical river users on the Calgary Bow River and safety history at the Calgary Weir were discussed along with other topics such as the Calgary Bow River weir project criteria; project design progress; pre-feasibility options; scale modelling; final design analysis; construction funding; and proposed changes to the safety program for the new weir configuration. figs.

Nuclear safety project

International Nuclear Information System (INIS)

1984-11-01

The semiannual progress report 1984/1 is a description of work within the Nuclear Safety Project performed in the first six month of 1984 in the nuclear safety field by KfK institutes and departements and by external institutions on behalf of KfK. The chosen kind of this report is that of short summaries, containing the topics work performed, results obtained and plans for future work. This report was compiled by the project management. (orig./RW) [de

Project Nuclear Safety

International Nuclear Information System (INIS)

1981-11-01

The semiannual progress report 1981/1 is a description of work within the Nuclear Safety Project performed in the first six month of 1981 in the nuclear safety field by KfK institutes and departments and by external institutions on behalf of KfK. The chosen kind of this report is that of short summaries, containing the topics, work performed, results obtained, plans for future work. This report was compiled by the project management. (orig.) [de

The General Safety Group Annual Report 2001/2002

CERN Document Server

Weingarten, W

2003-01-01

This report summarizes the main activities of the General Safety (GS) Group of the Technical Inspection and Safety Division during 2001 and 2002, and the results obtained. The different topics in which the group is active are covered: general safety inspections and ergonomics, electrical, chemical and gas safety, chemical pollution containment and control, industrial hygiene, the safety of civil engineering works and outside contractors, fire prevention and the safety aspects of the LHC experiments.

Proceedings of the topical meeting on reactivity initiated accidents (RIA)

International Nuclear Information System (INIS)

2003-01-01

The topical meeting was devoted to RIA fuel acceptance criteria, in particular to the fuel fragmentation enthalpy limit and the PCMI failure enthalpy limit in relation to high burnup fuel. In total 50 participants attended. Research and industry organisations from France, Finland, Germany, Hungary, Japan, the Russian Federation, Sweden, the United Kingdom and the USA including the Swiss regulatory body, HSK, and the Halden reactor project, presented 16 papers in all. The papers covered three main areas: 'best estimate' core calculations for RIA energy deposition in high burnup fuels, the technical background of current and new RIA fuel safety criteria, and ongoing RIA experimental programmes. A number of open issues were identified, whose resolution is expected from ongoing and planned national and international experimental programmes

Non-clinical models: validation, study design and statistical consideration in safety pharmacology.

Science.gov (United States)

Pugsley, M K; Towart, R; Authier, S; Gallacher, D J; Curtis, M J

2010-01-01

The current issue of the Journal of Pharmacological and Toxicological Methods (JPTM) focuses exclusively on safety pharmacology methods. This is the 7th year the Journal has published on this topic. Methods and models that specifically relate to methods relating to the assessment of the safety profile of a new chemical entity (NCE) prior to first in human (FIH) studies are described. Since the Journal started publishing on this topic there has been a major effort by safety pharmacologists, toxicologists and regulatory scientists within Industry (both large and small Pharma as well as Biotechnology companies) and also from Contract Research Organizations (CRO) to publish the surgical details of the non-clinical methods utilized but also provide important details related to standard and non-standard (or integrated) study models and designs. These details from core battery and secondary (or ancillary) drug safety assessment methods used in drug development programs have been the focus of these special issues and have been an attempt to provide validation of methods. Similarly, the safety pharmacology issues of the Journal provide the most relevant forum for scientists to present novel and modified methods with direct applicability to determination of drug safety-directly to the safety pharmacology scientific community. The content of the manuscripts in this issue includes the introduction of additional important surgical methods, novel data capture and data analysis methods, improved study design and effects of positive control compounds with known activity in the model. Copyright 2010 Elsevier Inc. All rights reserved.

Economic consideration of nuclear safety and cost benefit analysis in nuclear safety regulation

International Nuclear Information System (INIS)

Choi, Y. S.; Choi, K. S.; Choi, K. W.; Song, I. J.; Park, D. K.

2001-01-01

For the optimization of nuclear safety regulation, understanding of economic aspects of it becomes increasingly important together with the technical approach used so far to secure nuclear safety. Relevant economic theories on private and public goods were reviewed to re-illuminate nuclear safety from the economic perspective. The characteristics of nuclear safety as a public good was reviewed and discussed in comparison with the car safety as a private safety good. It was shown that the change of social welfare resulted from the policy change induced can be calculated by the summation of compensating variation(CV) of individuals. It was shown that the value of nuclear safety could be determined in monetary term by this approach. The theoretical background and history of cost benefit analysis of nuclear safety regulation were presented and topics for future study were suggested

A new standard for multidisciplinary health and safety technicians

International Nuclear Information System (INIS)

Trinoskey, P.A.; Fry, L.A.; Egbert, W.F.

2000-01-01

Over the last two decades, a significant trend in health and safety has been toward greater specialization. However, compartmentalization of health and safety disciplines often leads to an inequity in resources, especially when appropriations overemphasize one risk to the detriment of others. For example, overemphasis on radiological safety can create an imbalance in overall worker protection. A multidisciplinary technical can help restore the balance and provide for a healthier and safer work environment. The key advantages of a multidisciplinary health and safety technician include: Broad coverage of the work area by one technician, More diverse use of the technician pool, Better coverage for off-shift or nonstandard hours, Balance of risks because all hazards are considered, Integrated emergency response, Ownership, Less time of identify the correct person with the requisite skills. We have developed a new standard that establishes the training and related qualifications for a multidisciplinary health and safety technician. The areas of training and qualification that are addressed include elements of industrial hygiene, industrial safety, fire protection, electrical safety, construction safety, and radiation safety. The initial core training program ensures that individuals are trained to the performance of requirements of the job. Initial training is in five areas: Fundamentals, Hazard recognition, Hazard assessment, Hazards controls, Hazards minimization. Core training is followed by formal qualification on specific tasks, including ventilation surveys, air monitoring, noise assessments, radiological monitoring, area inspections, work-area setups, and work coverage. The new standard addresses not only training topics and requirements, but also guidance to ensure that performance objectives are met. The standard applies to technicians, supervisors, technologists, and six specialty areas, including academic institutions and decontamination and decommissioning

A new standard for multidisciplinary health and safety technicians

Energy Technology Data Exchange (ETDEWEB)

Trinoskey, P.A.; Fry, L.A. [Lawrence Livermore National Laboratory, Univ. of California, CA (United States); Egbert, W.F. [Lawrence Livermore National Laboratory, Allied Signal Technical Corporation (United States)

2000-05-01

Over the last two decades, a significant trend in health and safety has been toward greater specialization. However, compartmentalization of health and safety disciplines often leads to an inequity in resources, especially when appropriations overemphasize one risk to the detriment of others. For example, overemphasis on radiological safety can create an imbalance in overall worker protection. A multidisciplinary technical can help restore the balance and provide for a healthier and safer work environment. The key advantages of a multidisciplinary health and safety technician include: Broad coverage of the work area by one technician, More diverse use of the technician pool, Better coverage for off-shift or nonstandard hours, Balance of risks because all hazards are considered, Integrated emergency response, Ownership, Less time of identify the correct person with the requisite skills. We have developed a new standard that establishes the training and related qualifications for a multidisciplinary health and safety technician. The areas of training and qualification that are addressed include elements of industrial hygiene, industrial safety, fire protection, electrical safety, construction safety, and radiation safety. The initial core training program ensures that individuals are trained to the performance of requirements of the job. Initial training is in five areas: Fundamentals, Hazard recognition, Hazard assessment, Hazards controls, Hazards minimization. Core training is followed by formal qualification on specific tasks, including ventilation surveys, air monitoring, noise assessments, radiological monitoring, area inspections, work-area setups, and work coverage. The new standard addresses not only training topics and requirements, but also guidance to ensure that performance objectives are met. The standard applies to technicians, supervisors, technologists, and six specialty areas, including academic institutions and decontamination and decommissioning

78 FR 36091 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-06-17

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Systematic evaluation program review of NRC safety topic VII-2 associated with the electrical, instrumentation and control portions of the ESF system control logic and design for the Dresden Station, Unit II nuclear power plant

International Nuclear Information System (INIS)

St Leger-Barter, G.

1980-11-01

This report documents the technical evaluation and review of NRC Safety Topic VII-2, associated with the electrical, instrumentation, and control portions of the ESF system control logic and design for the Dresden Station Unit II nuclear power plant, using current licensing criteria

Project SAFE. Update of the SFR-1 safety assessment. Phase 1

International Nuclear Information System (INIS)

Andersson, Johan; Riggare, P.; Skagius, K.

1998-10-01

SFR-1 is a facility for disposal of low-level radioactive operational waste from the nuclear power plants in Sweden. Low-level radioactive waste from industry, medicine, and research is also disposed in SFR-1. The facility is situated in bedrock beneath the Baltic Sea, 1 km off the coast near the Forsmark nuclear power plant. SFR-1 was built between the years 1983 and 1988. An assessment of the long-term performance of the facility was included in the vast documentation that was a part of the application for an operational license. The assessment was presented in the form of a final safety report. In the operational licence for SFR-1 it is stated that renewed safety assessments should be carried out at least each ten years. In order to meet this demand SKB has launched a special project, SAFE (Safety Assessment of Final Disposal of Operational Radioactive Waste). The aim of the project is to update the safety analysis and to prepare a safety report that will be presented to the Swedish authorities not later than year 2000. Project SAFE is divided into three phases. The first phase is a prestudy, and the results of the prestudy are given in this report. The aim of the prestudy is to identify issues where additional studies would improve the basis for the updated safety analysis as well as to suggest how these studies should be carried out. The work has been divided into six different topics, namely the inventory, the near field, the far field, the biosphere, radionuclide transport calculations and scenarios. For each topic the former safety reports and regulatory reviews are scrutinised and needs for additional work is identified. The evaluations are given in appendices covering the respective topics. The main report is a summary of the appendices with a more stringent description of the repository system and the processes that are of interest and therefore should be addressed in an updated safety assessment. However, it should be pointed out that one of the

Space Nuclear Safety Program. Progress report, November 1983

International Nuclear Information System (INIS)

Bronisz, S.E.

1984-06-01

This technical monthly report covers studies related to the use of 238 PuO 2 in radioisotope power systems carried out for the Office of Special Nuclear Projects of the US Department of Energy by Los Alamos National Laboratory. Topics discussed include: safety-verification impact tests; explosion test; fragment test; leaking fueled clads; effects of fresh water and seawater or PuO 2 pellets; and impact tests of 5 watt radioisotope thermoelectric generator

Main technical topics in 1999; Les elements marquants de 1999

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-07-01

This Safety Authority annual report strives to present current organizational provisions and future trends in nuclear safety supervision in France and to describe the most outstanding occurrences during the past year. A first part presents nine documents concerning the main topics of 1999: aging of nuclear installations, the Offsite Emergency Plans (PPI), the impact of nuclear activities on man and the environment, the criticality hazards, EDF in 1999, the EPR project, the Andra in 1999, the transport incidents, the nuclear safety in eastern Europe. The second part presents the missions and actions of the Nuclear Installations Safety in the domains of the liabilities, the organization of the nuclear safety control, the regulations of the INB, the public information, the international relations, the crisis management, the radioactive materials transportation, the radioactive wastes. The equipment, the radiation protection and the exploitation of the pressurized water reactors are also treated just as the experimental reactors, the fuel cycle installations and the the nuclear installations dismantling. (A.L.B.)

Helmholtz-Zentrum Dresden-Rossendorf, Institute of Safety Research. Annual report 2010

Energy Technology Data Exchange (ETDEWEB)

Gerbeth, Gunter; Schaefer, Frank (eds.)

2011-07-01

The Institute of Safety Research (ISR) was over the past 20 years one of the six Research Institutes of Forschungszentrum Dresden-Rossendorf e.V. (FZD), which in 2010 belonged to the Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz. Together with the Institutes of Radiochemistry and Radiation Physics, ISR implements the research programme ''Nuclear Safety Research'' (NSR), which was during last years one of the three scientific programmes of FZD. NSR involves two main topics, i.e. ''Safety Research for Radioactive Waste Disposal'' and ''Safety Research for Nuclear Reactors''. The research of ISR aims at assessing and enhancing the safety of current and future reactors, the development of advanced simulation tools including their validation against experimental data, and the development of the appropriate measuring techniques for multi-phase flows and liquid metals.

Report of the State Office for Nuclear Safety on state supervision of nuclear safety of nuclear facilities and radiation protection in 1998

International Nuclear Information System (INIS)

1999-05-01

The legislative basis of the authority of the State Office for Nuclear Safety as the Czech national regulatory body is outlined, its organizational scheme is presented, and the responsibilities of the various departments are highlighted. The operation of major Czech nuclear facilities, including the Dukovany NPP which is in operation and the Temelin NPP which is under construction, is described with respect to nuclear safety. Since the Office's responsibilities also cover radiation protection in the Czech Republic, a survey of ionizing radiation sources and their supervision is given. Other topics include, among other things, nuclear material transport, the state system for nuclear materials accountancy and control, central registries for radiation protection, nuclear waste management, the National Radiation Monitoring Network, personnel qualification and training, emergency planning, legislative activities, international cooperation, and public information. (P.A.)

Topical thrombin preparations and their use in cardiac surgery

Directory of Open Access Journals (Sweden)

Brianne L Dunn

2009-10-01

Full Text Available Brianne L Dunn1, Walter E Uber1, John S Ikonomidis21Department of Pharmacy Services and 2Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USAAbstract: Coagulopathic bleeding may lead to increased morbidity and mortality after cardiac surgery. Topical bovine thrombin has been used to promote hemostasis after surgical procedures for over 60 years and is used frequently as a topical hemostatic agent in cardiac surgery. Recently, use of bovine thrombin has been reported to be associated with increased risk for anaphylaxis, thrombosis, and immune-mediated coagulopathy thought secondary to the production of antifactor V and antithrombin antibodies. In patients who develop bovine thrombin-induced immune-mediated coagulopathy, clinical manifestations may range from asymptomatic alterations in coagulation tests to severe hemorrhage and death. Patients undergoing cardiac surgical procedures may be at increased risk for development of antibodies to bovine thrombin products and associated complications. This adverse immunologic profile has led to the development of alternative preparations including a human and a recombinant thrombin which have been shown to be equally efficacious to bovine thrombin and have reduced antigenicity. However, the potential benefit associated with reduced antigenicity is not truly known secondary to the lack of long-term experience with these products. Given the potentially higher margin of safety and less stringent storage concerns compared to human thrombin, recombinant thrombin may be the most reasonable approach in cardiac surgery.Keywords: bovine thrombin, human thrombin, recombinant thrombin, immune-mediated coagulopathy, topical hemostatic agents, thrombin 

77 FR 20295 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago...

Science.gov (United States)

2012-04-04

... Zone, Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

75 FR 73966 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2010-11-30

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

77 FR 35854 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2012-06-15

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

76 FR 2829 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2011-01-18

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

75 FR 52462 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2010-08-26

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan including Des Plaines...

Proceedings of the fourth international topical meeting on nuclear thermal hydraulics, operations and safety. Vol. 1

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

More than 100 papers were presented. The meeting was divided in 56 sessions and covered the following topics: Plant Operation, Retrofitting and Maintenance Experience; Steam Generator Operation and Maintenance; Artificial Intelligence and Expert Systems; Seismic Technologies for Plant Design and Operations; Aging Management and Life Extension; Two-Phase Flow Modeling and Applications; Severe Accidents and Degraded Core Thermal Hydraulics; Plant Simulators, Analyzers, and Workstations; Advanced Nuclear Fuel Challenges; Recent Nuclear Power Station Decommissioning Experiences in the USA; Application of Probabilistic risk assessment/Probabilistic safety assessment (PRA/PSA) in Design and Modification; Numerical Modeling in Thermal Hydraulics; General Thermal Hydraulics; Severe Accident Management; Licensing and Regulatory Requirements; Advanced Light Water Reactor Designs to Support Reduced Emergency Planning; Best Estimate loss-of-coolant (LOCA) Methodologies; Plant Instrumentation and Control; LWR Fuel Designs for Improved Thermal Hydraulic Performance; Performance Assessment of Radioactive Waste Disposal; Thermal Hydraulics in Passive Reactor Systems; Advances in Man-Machine Interface Design and the Related Human Factors Engineering; Advances in Measurements and Instrumentation; Computer Aided Technology for non-destructive evaluation (NDE) and Plant Maintenance Plant Uprating; Flow-Accelerated Corrosion in Nuclear Power Plants; Advances in Radiological Measurement and Analysis Risk Management and Assessment; Stability in Thermal Hydraulic Systems; Critical heat flux (CHF) and Post Dryout Heat Transfer; Plant Transient and Accident Modeling.

Proceedings of the fourth international topical meeting on nuclear thermal hydraulics, operations and safety. Vol. 1

International Nuclear Information System (INIS)

2004-01-01

More than 100 papers were presented. The meeting was divided in 56 sessions and covered the following topics: Plant Operation, Retrofitting and Maintenance Experience; Steam Generator Operation and Maintenance; Artificial Intelligence and Expert Systems; Seismic Technologies for Plant Design and Operations; Aging Management and Life Extension; Two-Phase Flow Modeling and Applications; Severe Accidents and Degraded Core Thermal Hydraulics; Plant Simulators, Analyzers, and Workstations; Advanced Nuclear Fuel Challenges; Recent Nuclear Power Station Decommissioning Experiences in the USA; Application of Probabilistic risk assessment/Probabilistic safety assessment (PRA/PSA) in Design and Modification; Numerical Modeling in Thermal Hydraulics; General Thermal Hydraulics; Severe Accident Management; Licensing and Regulatory Requirements; Advanced Light Water Reactor Designs to Support Reduced Emergency Planning; Best Estimate loss-of-coolant (LOCA) Methodologies; Plant Instrumentation and Control; LWR Fuel Designs for Improved Thermal Hydraulic Performance; Performance Assessment of Radioactive Waste Disposal; Thermal Hydraulics in Passive Reactor Systems; Advances in Man-Machine Interface Design and the Related Human Factors Engineering; Advances in Measurements and Instrumentation; Computer Aided Technology for non-destructive evaluation (NDE) and Plant Maintenance Plant Uprating; Flow-Accelerated Corrosion in Nuclear Power Plants; Advances in Radiological Measurement and Analysis Risk Management and Assessment; Stability in Thermal Hydraulic Systems; Critical heat flux (CHF) and Post Dryout Heat Transfer; Plant Transient and Accident Modeling

Proceedings of the fourth international topical meeting on nuclear thermal hydraulics, operations and safety. Vol. 2

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

More than 100 papers presented at the meeting were divided in 56 sessions and covered the following topics: Plant Operation, Retrofitting and Maintenance Experience; Steam Generator Operation and Maintenance; Artificial Intelligence and Expert Systems; Seismic Technologies for Plant Design and Operations; Aging Management and Life Extension; Two-Phase Flow Modeling and Applications; Severe Accidents and Degraded Core Thermal Hydraulics; Plant Simulators, Analyzers, and Workstations; Advanced Nuclear Fuel Challenges; Recent Nuclear Power Station Decommissioning Experiences in the USA; Application of Probabilistic risk assessment/Probabilistic safety assessment (PRA/PSA) in Design and Modification; Numerical Modeling in Thermal Hydraulics; General Thermal Hydraulics; Severe Accident Management; Licensing and Regulatory Requirements; Advanced Light Water Reactor Designs to Support Reduced Emergency Planning; Best Estimate loss-of-coolant (LOCA) Methodologies; Plant Instrumentation and Control; LWR Fuel Designs for Improved Thermal Hydraulic Performance; Performance Assessment of Radioactive Waste Disposal; Thermal Hydraulics in Passive Reactor Systems; Advances in Man-Machine Interface Design and the Related Human Factors Engineering; Advances in Measurements and Instrumentation; Computer Aided Technology for non-destructive evaluation (NDE) and Plant Maintenance Plant Uprating; Flow-Accelerated Corrosion in Nuclear Power Plants; Advances in Radiological Measurement and Analysis Risk Management and Assessment; Stability in Thermal Hydraulic Systems; Critical heat flux (CHF) and Post Dryout Heat Transfer; Plant Transient and Accident Modeling.

Proceedings of the fourth international topical meeting on nuclear thermal hydraulics, operations and safety. Vol. 2

International Nuclear Information System (INIS)

2004-01-01

More than 100 papers presented at the meeting were divided in 56 sessions and covered the following topics: Plant Operation, Retrofitting and Maintenance Experience; Steam Generator Operation and Maintenance; Artificial Intelligence and Expert Systems; Seismic Technologies for Plant Design and Operations; Aging Management and Life Extension; Two-Phase Flow Modeling and Applications; Severe Accidents and Degraded Core Thermal Hydraulics; Plant Simulators, Analyzers, and Workstations; Advanced Nuclear Fuel Challenges; Recent Nuclear Power Station Decommissioning Experiences in the USA; Application of Probabilistic risk assessment/Probabilistic safety assessment (PRA/PSA) in Design and Modification; Numerical Modeling in Thermal Hydraulics; General Thermal Hydraulics; Severe Accident Management; Licensing and Regulatory Requirements; Advanced Light Water Reactor Designs to Support Reduced Emergency Planning; Best Estimate loss-of-coolant (LOCA) Methodologies; Plant Instrumentation and Control; LWR Fuel Designs for Improved Thermal Hydraulic Performance; Performance Assessment of Radioactive Waste Disposal; Thermal Hydraulics in Passive Reactor Systems; Advances in Man-Machine Interface Design and the Related Human Factors Engineering; Advances in Measurements and Instrumentation; Computer Aided Technology for non-destructive evaluation (NDE) and Plant Maintenance Plant Uprating; Flow-Accelerated Corrosion in Nuclear Power Plants; Advances in Radiological Measurement and Analysis Risk Management and Assessment; Stability in Thermal Hydraulic Systems; Critical heat flux (CHF) and Post Dryout Heat Transfer; Plant Transient and Accident Modeling

Comparative assessment of safety indicators for vehicle trajectories on the highway

NARCIS (Netherlands)

Mullakkal Babu, F.A.; Wang, M.; Farah, H.; van Arem, B.; Happee, R.

2017-01-01

Safety measurement and analysis have been a challenging and well-researched topic in transportation. Conventionally, surrogate safety measures have been used as safety indicators in simulation models for safety assessment, in control formulations for driver assistance systems, and in data analysis

77 FR 25595 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2012-05-01

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Safety Zone; Brandon Road Lock and [[Page 25596

2011 NASA Range Safety Annual Report

Science.gov (United States)

Dumont, Alan G.

2012-01-01

Welcome to the 2011 edition of the NASA Range Safety Annual Report. Funded by NASA Headquarters, this report provides a NASA Range Safety overview for current and potential range users. As is typical with odd year editions, this is an abbreviated Range Safety Annual Report providing updates and links to full articles from the previous year's report. It also provides more complete articles covering new subject areas, summaries of various NASA Range Safety Program activities conducted during the past year, and information on several projects that may have a profound impact on the way business will be done in the future. Specific topics discussed and updated in the 2011 NASA Range Safety Annual Report include a program overview and 2011 highlights; Range Safety Training; Range Safety Policy revision; Independent Assessments; Support to Program Operations at all ranges conducting NASA launch/flight operations; a continuing overview of emerging range safety-related technologies; and status reports from all of the NASA Centers that have Range Safety responsibilities. Every effort has been made to include the most current information available. We recommend this report be used only for guidance and that the validity and accuracy of all articles be verified for updates. Once again the web-based format was used to present the annual report. We continually receive positive feedback on the web-based edition and hope you enjoy this year's product as well. As is the case each year, contributors to this report are too numerous to mention, but we thank individuals from the NASA Centers, the Department of Defense, and civilian organizations for their contributions. In conclusion, it has been a busy and productive year. I'd like to extend a personal Thank You to everyone who contributed to make this year a successful one, and I look forward to working with all of you in the upcoming year.

Researches in nuclear safety

International Nuclear Information System (INIS)

Souchet, Y.

2009-01-01

This article comprises three parts: 1 - some general considerations aiming at explaining the main motivations of safety researches, and at briefly presenting the important role of some organisations in the international conciliation, and the most common approach used in safety researches (analytical experiments, calculation codes, global experiments); 2 - an overview of some of the main safety problems that are the object of worldwide research programs (natural disasters, industrial disasters, criticality, human and organisational factors, fuel behaviour in accidental situation, serious accidents: core meltdown, corium spreading, failure of the confinement building, radioactive releases). Considering the huge number of research topics, this part cannot be exhaustive and many topics are not approached; 3 - the presentation of two research programs addressing very different problems: the evaluation of accidental releases in the case of a serious accident (behaviour of iodine and B 4 C, air infiltration, fission products release) and the propagation of a fire in a facility (PRISME program). These two programs belong to an international framework involving several partners from countries involved in nuclear energy usage. (J.S.)

Radiation safety and quality control assurance in X-ray diagnostics 1998

International Nuclear Information System (INIS)

Servomaa, A.

1998-03-01

The report is based on a seminar course of lectures 'Radiation safety and quality assurance in X-ray diagnostics 1998' organized by the Radiation and Nuclear Safety Authority (STUK) in Finland. The lectures included actual information on X-ray examinations: methods of quality assurance, methods of measuring and calculating patient doses, examination frequencies, patient doses, occupational doses, and radiation risks. Paediatric X-ray examinations and interventional procedures were the most specific topics. The new Council Directive 97/43/Euratom on medical exposure, and the European Guidelines on quality criteria for diagnostic radiographic images, were discussed in several lectures. Lectures on general radiation threats and preparedness, examples of radiation accidents, and emergency preparedness in hospitals were also included. (editor)

Using driving simulators to assess driving safety.

Science.gov (United States)

Boyle, Linda Ng; Lee, John D

2010-05-01

Changes in drivers, vehicles, and roadways pose substantial challenges to the transportation safety community. Crash records and naturalistic driving data are useful for examining the influence of past or existing technology on drivers, and the associations between risk factors and crashes. However, they are limited because causation cannot be established and technology not yet installed in production vehicles cannot be assessed. Driving simulators have become an increasingly widespread tool to understand evolving and novel technologies. The ability to manipulate independent variables in a randomized, controlled setting also provides the added benefit of identifying causal links. This paper introduces a special issue on simulator-based safety studies. The special issue comprises 25 papers that demonstrate the use of driving simulators to address pressing transportation safety problems and includes topics as diverse as neurological dysfunction, work zone design, and driver distraction. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Integrated safety assessment report, Haddam Neck Plant (Docket No. 50-213): Integrated Safety Assessment Program: Draft report

International Nuclear Information System (INIS)

1987-07-01

The integrated assessment is conducted on a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. Procedures allow for a periodic updating of the schedules to account for licensing issues that arise in the future. The Haddam Neck Plant is one of two plants being reviewed under the pilot program. This report indicates how 82 topics selected for review were addressed, and presents the staff's recommendations regarding the corrective actions to resolve the 82 topics and other actions to enhance plant safety. 135 refs., 4 figs., 5 tabs

77 FR 26287 - Cooperative Agreement To Support the Joint Institute for Food Safety and Applied Nutrition...

Science.gov (United States)

2012-05-03

... not only traditional laboratory and field research, but also epidemiological, educational, social and... scientists. JIFSAN food safety research topics are diverse and include the development of methods for... and continue to stimulate the integration of applied research, education, and outreach programs. DATES...

TASS code topical report. V.1 TASS code technical manual

International Nuclear Information System (INIS)

Sim, Suk K.; Chang, W. P.; Kim, K. D.; Kim, H. C.; Yoon, H. Y.

1997-02-01

TASS 1.0 code has been developed at KAERI for the initial and reload non-LOCA safety analysis for the operating PWRs as well as the PWRs under construction in Korea. TASS code will replace various vendor's non-LOCA safety analysis codes currently used for the Westinghouse and ABB-CE type PWRs in Korea. This can be achieved through TASS code input modifications specific to each reactor type. The TASS code can be run interactively through the keyboard operation. A simimodular configuration used in developing the TASS code enables the user easily implement new models. TASS code has been programmed using FORTRAN77 which makes it easy to install and port for different computer environments. The TASS code can be utilized for the steady state simulation as well as the non-LOCA transient simulations such as power excursions, reactor coolant pump trips, load rejections, loss of feedwater, steam line breaks, steam generator tube ruptures, rod withdrawal and drop, and anticipated transients without scram (ATWS). The malfunctions of the control systems, components, operator actions and the transients caused by the malfunctions can be easily simulated using the TASS code. This technical report describes the TASS 1.0 code models including reactor thermal hydraulic, reactor core and control models. This TASS code models including reactor thermal hydraulic, reactor core and control models. This TASS code technical manual has been prepared as a part of the TASS code manual which includes TASS code user's manual and TASS code validation report, and will be submitted to the regulatory body as a TASS code topical report for a licensing non-LOCA safety analysis for the Westinghouse and ABB-CE type PWRs operating and under construction in Korea. (author). 42 refs., 29 tabs., 32 figs

[Learning from errors: applying aviation safety concepts to medicine].

Science.gov (United States)

Sommer, K-J

2012-11-01

Health care safety levels range below other complex industries. Civil aviation has throughout its history developed methods and concepts that have made the airplane into one of the safest means of mass transport. Key elements are accident investigations that focus on cause instead of blame, human-centered design of machinery and processes, continuous training of all personnel and a shared safety culture. These methods and concepts can basically be applied to medicine which has successfully been achieved in certain areas, however, a comprehensive implementation remains to be completed. This applies particularly to including the topic of safety into relevant curricula. Physicians are obliged by the oath"primum nil nocere" to act, but economic as well as political pressure will eventually confine professional freedom if initiative is not taken soon.

Fuel Cycle Safety - Past, Present and Future. Wilmington, North Carolina, USA, 16-18 October 2007. Papers and presentations

International Nuclear Information System (INIS)

2007-10-01

At the October 2006 meeting of Working Group on Fuel Cycle Safety (WGFCS), participants agreed that several issues associated with the safety of the nuclear fuel cycle merit more detailed attention by regulators and industry. There was general agreement that more information, from a broader audience, would be of benefit both to regulators and the regulated industry. Therefore, this workshop was held in order to collect the views of interested parties from a global perspective. The workshop focused on the following three topics: - Legacy waste concerns (including facilities and waste); - Reprocessing of nuclear fuel and the recycling of nuclear waste; - Ensuring the safety of current and new fuel cycle facilities. The workshop was expected to provide additional insights on these three topics and enabled facility operators and regulators alike an opportunity to maintain and enhance safety in the future. This document brings together the available presentations (slides and papers) given at the meeting

Bare quantifier fronting as contrastive topicalization

Directory of Open Access Journals (Sweden)

Ion Giurgea

2015-11-01

Full Text Available I argue that indefinites (in particular bare quantifiers such as ‘something’, ‘somebody’, etc. which are neither existentially presupposed nor in the restriction of a quantifier over situations, can undergo topicalization in a number of Romance languages (Catalan, Italian, Romanian, Spanish, but only if the sentence contains “verum” focus, i.e. focus on a high degree of certainty of the sentence. I analyze these indefinites as contrastive topics, using Büring’s (1999 theory (where the term ‘S-topic’ is used for what I call ‘contrastive topic’. I propose that the topic is evaluated in relation to a scalar set including generalized quantifiers such as {lP $x P(x, lP MANYx P(x, lP MOSTx P(x, lP “xP(x} or {lP $xP(x, lP P(a, lP P(b …}, and that the contrastive topic is the weakest generalized quantifier in this set. The verum focus, which is part of the “comment” that co-occurs with the “Topic”, introduces a set of alternatives including degrees of certainty of the assertion. The speaker asserts that his claim is certainly true or highly probable, contrasting it with stronger claims for which the degree of probability is unknown. This explains the observation that in downward entailing contexts, the fronted quantified DPs are headed by ‘all’ or ‘many’, whereas ‘some’, small numbers or ‘at least n’ appear in upward entailing contexts. Unlike other cases of non-specific topics, which are property topics, these are quantifier topics: the topic part is a generalized quantifier, the comment is a property of generalized quantifiers. This explains the narrow scope of the fronted quantified DP.

An essential primer for understanding the role of topical hemostats, surgical sealants, and adhesives for maintaining hemostasis.

Science.gov (United States)

Gabay, Michael; Boucher, Bradley A

2013-09-01

A wide variety of topical hemostats are approved as adjunctive therapies in the maintenance of hemostasis during surgical procedures in which conventional methods are insufficient or not practical. A multidisciplinary approach to the selection and application of these agents requires input from all members of the surgical team including surgeons, perioperative nurses, blood bank specialists, and pharmacists. However, pharmacist knowledge regarding topical hemostats may be limited based on lack of formal education within college of pharmacy curricula as well as their use being predominantly in the operating room setting. Furthermore, some of these agents might be procured through central supply rather than the hospital pharmacy. Topical hemostats include agents that act as a mechanical barrier to bleeding and provide a physical matrix for clotting, biologically active agents that catalyze coagulation, combination therapies, and synthetic sealants and adhesives. Although many of the topical hemostats were approved for use before the requirement for clinical trials, this review provides an overview of the available clinical evidence regarding the appropriate uses and safety considerations associated with these agents. Proper use of these agents is vital to achieving the best clinical outcomes. Specifically, knowledge of the contraindications and potential adverse events associated with topical hemostats can help prevent unwanted outcomes. Therefore, an understanding of the benefits and potential risks associated with these agents will allow hospital pharmacists to assist in the development and implementation of institutional policies regarding the safe and effective use of hemostatic agents commonly used in the surgical suite. © 2013 Pharmacotherapy Publications, Inc.

Nuclear power and nuclear safety 2009

International Nuclear Information System (INIS)

Lauritzen, B.; Oelgaard, P.L.; Kampmann, D.; Nystrup, P.E.; Thorlaksen, B.

2010-05-01

The report is the seventh report in a series of annual reports on the international development of nuclear power production, with special emphasis on safety issues and nuclear emergency preparedness. The report is written in collaboration between Risoe DTU and the Danish Emergency Management Agency. The report for 2009 covers the following topics: status of nuclear power production, regional trends, reactor development, safety related events, international relations, conflicts and the European safety directive. (LN)

Safety advice sheets

CERN Multimedia

HSE Unit

2013-01-01

You never know when you might be faced with questions such as: when/how should I dispose of a gas canister? Where can I find an inspection report? How should I handle/store/dispose of a chemical substance…?   The SI section of the DGS/SEE Group is primarily responsible for safety inspections, evaluating the safety conditions of equipment items, premises and facilities. On top of this core task, it also regularly issues “Safety Advice Sheets” on various topics, designed to be of assistance to users but also to recall and reinforce safety rules and procedures. These clear and concise sheets, complete with illustrations, are easy to display in the appropriate areas. The following safety advice sheets have been issued so far: Other sheets will be published shortly. Suggestions are welcome and should be sent to the SI section of the DGS/SEE Group. Please send enquiries to general-safety-visits.service@cern.ch.

Plutonium safety training course

International Nuclear Information System (INIS)

Moe, H.J.

1976-03-01

This course seeks to achieve two objectives: to provide initial safety training for people just beginning work with plutonium, and to serve as a review and reference source for those already engaged in such work. Numerous references have been included to provide information sources for those wishing to pursue certain topics more fully. The first part of the course content deals with the general safety approach used in dealing with hazardous materials. Following is a discussion of the four properties of plutonium that lead to potential hazards: radioactivity, toxicity, nuclear properties, and spontaneous ignition. Next, the various hazards arising from these properties are treated. The relative hazards of both internal and external radiation sources are discussed, as well as the specific hazards when plutonium is the source. Similarly, the general hazards involved in a criticality, fire, or explosion are treated. Comments are made concerning the specific hazards when plutonium is involved. A brief summary comparison between the hazards of the transplutonium nuclides relative to 239 Pu follows. The final portion deals with control procedures with respect to contamination, internal and external exposure, nuclear safety, and fire protection. The philosophy and approach to emergency planning are also discussed

COMPARATIVE STUDY OF TOPICAL MOMETASONE FUROATE 0.1%, TOPICAL 0.03% TACROLIMUS, TOPICAL BASIC FIBROBLAST GROWTH FACTOR (bFGF IN CHILDHOOD VITILIGO

Directory of Open Access Journals (Sweden)

Kavitha S. B

2017-08-01

Full Text Available BACKGROUND Vitiligo, the commonest of all pigmentary disorders, is an idiopathic, acquired cutaneous achromia, characterised by circumscribed, chalky white macules. It may also involve the pigment epithelium of the eyes, the inner ear and the leptomeninges. Although, vitiligo can begin at any age, it develops before the age of 20 years in 50% of the patients and before the age of 10 years in 25% of patients. MATERIALS AND METHODS The study was conducted for a period of one year with 6 months active intervention. A group of 60 consecutive children attending the outpatient Department of Dermatology were included in this study. The same patients were acting as controls. RESULTS Grade 4 response was seen in 12 cases (60% who were on mometasone (VV-20%, focal-30%, segmental-10%, in 10 cases (50% on tacrolimus (VV-20%, focal-30% and in 4 cases (20% on bFGF (focal. Lesions on the face and neck showed grade 4 response in 16 cases (mometasone-8, tacrolimus-6 and bFGF-2, extremities in 6 cases. On the whole grade, 4 response was observed more with mometasone (60% followed by tacrolimus (50%. Grade 3 response was observed with bFGF (30%. CONCLUSION Topical mometasone was very effective among the 3 drugs used in childhood vitiligo showing grade 4 repigmentation in all types of vitiligo except mucosal vitiligo. Tacrolimus proved almost as effective as mometasone to restore skin colour in lesions of vitiligo in children. Because it does not produce atrophy or other adverse effects, tacrolimus may be very useful for younger patients, and for sensitive areas of the skin such as eyelids, it should be considered in other skin disorders currently treated with topical steroids for prolonged periods. Topical basic fibroblast growth factor though less effective than mometasone and tacrolimus, but can be tried as initial therapy in resistant cases such as segmental vitiligo as initial therapy of small vitiligo patches when physicians may not like to initiate high risk

Eminent radiological safety issues confronting the State of Hawaii

International Nuclear Information System (INIS)

Hashimoto, H.H.

1984-01-01

The State of Hawaii currently has over one hundred radioactive material use licenses. Nuclear Regulatory Commission licenses are primarily held by hospitals, industrial radiographers, and academic institutions. Complementing this, the State Department of Health regulates x-ray machines, radium, and has an emergency response role for accidents involving radioactive materials. The existing radiation protection program was created by piecemeal legislation. As a result, regulatory surveillance and actual control vary widely among the agencies. The State Legislature, in 1980, decided that action must be taken to set a clear state policy towards the use and disposal of nuclear materials. It was therefore recommended that the State of Hawaii Radiation Safety Advisory Committee be convened to assist the state in the evaluation of the issues. This report contains issue papers on radiation related topics addressed by the Radiation Safety Advisory Committe. Topics discussed include transportation, environmental monitoring, emergency response, and waste disposal. A survey of various radioactive sources identified medical applications as a category requiring stricter control. Selected chapters of the Hawaii Revised Statutes are also examined

Topical Antibacterials and Global Challenges on Resistance ...

African Journals Online (AJOL)

skin infections can be easily treated with topical antibacterial medication that is available over the counter or by ... infection in minor cut or burn, eyes and ear infection [5]. .... Sensitive/dry skin ... includes both oral and topical antibiotics, but.

Safety activities and human resource development at NCA

International Nuclear Information System (INIS)

Kumanomido, Hironori; Sakurada, Koichi; Yanagisawa, Shigeru; Masuyama, Tadaharu

2015-01-01

Toshiba Nuclear Critical Assembly (NCA) has been safely operated since the first criticality in December 1963. The topics covered in this Yayoi Meeting Report are: (1) the outline of NCA, (2) the safety control situation mainly after the Great East Japan Earthquake in 2011, (3) educational training incorporates the lessons learned in this earthquake, and (4) human resource development during 2008-2015. Regarding safety control, facility maintenance has been conducted systematically according to the maintenance plan from the viewpoint of preventive maintenance. Regarding educational training, two disaster handling training based on the safety regulation and one nuclear emergency drill based on the emergency drill plan for licensee of nuclear energy activity based on the Act of Special Measures Concerning Nuclear Emergency Preparedness every year. Regarding human resource development, development training was given to 358 people including students. This year, training that does not require NCA operation was conducted including gamma-ray spectrum measurement of NCA fuel rod and neutron deceleration property measurement using 252 Cf neutron source. (S.K.)

Rossendorf Research Center, Institute of Safety Research. Annual report 1991

International Nuclear Information System (INIS)

Boehmert, J.; Weiss, F.P.

1992-08-01

The working program covers above all topics concerning the assessment of design basis safety and the increase of operational safety of the WWER type reactors. The topics are directed to the WWER-440/213 type and to the WWER-1000 type, and are dealt with by the three departments, i.e. incident analysis, neutron embrittlement, and mechanical integrity. One paper is concerned with the determination of the neutron field of HERA. (orig.) [de

77 FR 51731 - All-Terrain Vehicle Safety Summit

Science.gov (United States)

2012-08-27

...; Physical sizing of ATVs 2. Consumer Awareness Suggested topics: Point-of-purchase information; on-product... safety require additional research that is beyond the Commission's current budget and resources. CPSC.... The Summit will take place over 2 days and will feature a mix of rulemaking and nonrulemaking topic...

Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial.

Science.gov (United States)

Strunk, Tobias; Pupala, Sameer; Hibbert, Julie; Doherty, Dorota; Patole, Sanjay

2018-01-01

The immature fragile skin of preterm infants represents an inadequate protective barrier. The emollient and anti-infective properties of coconut oil make it a potentially beneficial topical agent for this population. Our aim was to evaluate feasibility, safety, and the effects of topical coconut oil on skin condition in very preterm infants. An open-label randomised controlled trial in preterm infants coconut oil (5 mL/kg) twice daily for 21 days, starting within 24 h of birth. The neonatal skin condition was the primary outcome, and was assessed using the Neonatal Skin Condition Score (NSCS) on days 1, 7, 14, and 21. The number of coconut oil applications was recorded to assess clinical feasibility and all enrolled infants were monitored for adverse effects of topical coconut application, such as skin irritation. A total of 72 infants born coconut oil was feasible and without adverse effects. The NSCS was maintained in the coconut oil group throughout the intervention period, but deteriorated from a median (IQR) of 3 (3-4) on day 1 to 4 (4-4) on day 21 in the control group (p = 0.01). There were no differences in common neonatal outcomes, including sepsis, necrotising enterocolitis, retinopathy of prematurity, chronic lung disease, and mortality. Topical coconut oil maintained a better skin condition in very preterm infants without adverse effects. This simple, safe, and affordable intervention warrants further investigation. © 2017 S. Karger AG, Basel.

WHO guidance grounded in a comprehensive approach to sexual and reproductive health and human rights: topical pre-exposure prophylaxis

OpenAIRE

Lusti-Narasimhan, Manjula; Khosla, Rajat; Baggaley, Rachel; Temmerman, Marleen; McGrory, Elizabeth; Farley, Tim

2014-01-01

Introduction: Two new microbicide products based on topical (vaginal) application of antiretroviral drugs – 1% tenofovir gel and the dapivirine ring – are currently in late-stage clinical testing, and results on their safety and effectiveness are expected to become available in early 2015. WHO guidelines on the use of topical pre-exposure prophylaxis (topical PrEP) are important in order to ensure that these new prevention products are optimally used. Discussion: Given that these new topical ...

Time series modeling in traffic safety research.

Science.gov (United States)

Lavrenz, Steven M; Vlahogianni, Eleni I; Gkritza, Konstantina; Ke, Yue

2018-08-01

The use of statistical models for analyzing traffic safety (crash) data has been well-established. However, time series techniques have traditionally been underrepresented in the corresponding literature, due to challenges in data collection, along with a limited knowledge of proper methodology. In recent years, new types of high-resolution traffic safety data, especially in measuring driver behavior, have made time series modeling techniques an increasingly salient topic of study. Yet there remains a dearth of information to guide analysts in their use. This paper provides an overview of the state of the art in using time series models in traffic safety research, and discusses some of the fundamental techniques and considerations in classic time series modeling. It also presents ongoing and future opportunities for expanding the use of time series models, and explores newer modeling techniques, including computational intelligence models, which hold promise in effectively handling ever-larger data sets. The information contained herein is meant to guide safety researchers in understanding this broad area of transportation data analysis, and provide a framework for understanding safety trends that can influence policy-making. Copyright © 2017 Elsevier Ltd. All rights reserved.

Safety Leadership Defined within the Australian Construction Industry

OpenAIRE

Daniel, Luke

2015-01-01

This research explores the tenets of safety leadership within the Australian construction environment. The scope of this research aims to establish a universal definition of safety leadership and how it differs from other leadership disciplines. The literature review into this topic was governed by the parent disciplines of Safety and Leadership.  Gaps were identified in the literature that indicated safety leadership is not a well-defined concept and much of the work into safety leadership h...

Topical points of community policy concerning nuclear safety relevant to the Internal Market

International Nuclear Information System (INIS)

Schroeder, M.

1991-01-01

Starting with the Internal Market concept, the lecture describes general and specific expectations directed to the nuclear community from a point of view of nuclear safety, and analyzes those aspects of nuclear safety, EC policy focuses on. There are the following chapters: 1. Selection of sites for nuclear installations, 2. installation and reactor safety, 3. radioactive waste management, 4. decommissioning of nuclear installations, 5. radioactive waste storage, 6. coping with nuclear accidents and other radiological emergency situations. Sophistication of public health and environmental protection within the framework of the EURATOM Treaty is seen in connection with interim and final storage as well as reprocessing of radioactive waste, and with the decommissioning of nuclear facilities on the basis of section 30 ff., and installation and reactor safety on the basis of section 203 EURATOM Treaty. Improving the protection of public health in particular is possible and necessary in order to make the EURATOM community into a proper nuclear community of law. (orig./HSCH) [de

To Your Health: NLM update transcript - Gun safety strategies

Science.gov (United States)

... transcript040918.html To Your Health: NLM update Transcript Gun safety strategies : 04/09/2018 To use the ... on weekly topics. An evidence-based, public health gun safety strategy that is consistent with second amendment ...

Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents.

Science.gov (United States)

Scheinfeld, Noah

2014-07-15

Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n-methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS . Doxepin is available in a 3% or 3.3% concentration (which causes less drowsiness) from compounding pharmacies and can be used in compounded analgesic preparations with positive effect. Topical doxepin is preferred over use of topical amitriptyline because topical doxepin is more effective. Nevertheless, topical amitriptyline increase of the tactile and mechanical nociceptive thresholds and can be used for topical pain control in compound mixture of analgesics . Gabapentin and pregablin can also be used compounded with other agents in topical analgesic preparations with positive topical anesthetic effect. Capsaicin is not useful for topical treatment of the pain of HS. Sometimes compounded of anesthetics medications such as ketamine 10%, bupivacaine 1%, diclofenac 3%, doxepin 3% or 3.3%, and gabapentin 6% can extend the duration of effect so that medication only needs to be used 2 or 3 times a day. Still in my experience the easiest to get and most patient requested agent is topical diclonefac 1% gel.

Patient safety in otolaryngology: a descriptive review.

Science.gov (United States)

Danino, Julian; Muzaffar, Jameel; Metcalfe, Chris; Coulson, Chris

2017-03-01

Human evaluation and judgement may include errors that can have disastrous results. Within medicine and healthcare there has been slow progress towards major changes in safety. Healthcare lags behind other specialised industries, such as aviation and nuclear power, where there have been significant improvements in overall safety, especially in reducing risk of errors. Following several high profile cases in the USA during the 1990s, a report titled "To Err Is Human: Building a Safer Health System" was published. The report extrapolated that in the USA approximately 50,000 to 100,000 patients may die each year as a result of medical errors. Traditionally otolaryngology has always been regarded as a "safe specialty". A study in the USA in 2004 inferred that there may be 2600 cases of major morbidity and 165 deaths within the specialty. MEDLINE via PubMed interface was searched for English language articles published between 2000 and 2012. Each combined two or three of the keywords noted earlier. Limitations are related to several generic topics within patient safety in otolaryngology. Other areas covered have been current relevant topics due to recent interest or new advances in technology. There has been a heightened awareness within the healthcare community of patient safety; it has become a major priority. Focus has shifted from apportioning blame to prevention of the errors and implementation of patient safety mechanisms in healthcare delivery. Type of Errors can be divided into errors due to action and errors due to knowledge or planning. In healthcare there are several factors that may influence adverse events and patient safety. Although technology may improve patient safety, it also introduces new sources of error. The ability to work with people allows for the increase in safety netting. Team working has been shown to have a beneficial effect on patient safety. Any field of work involving human decision-making will always have a risk of error. Within

76 FR 65609 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2011-10-24

... Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship Canal... Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal, Chicago... INFORMATION: The Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake...

75 FR 64147 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2010-10-19

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Ship and Sanitary Canal... . SUPPLEMENTARY INFORMATION: The Coast Guard will enforce Safety Zone, Brandon Road Lock and Dam to Lake Michigan...

[Bioequivalence of dermatological topical medicines:the Brazilian scenario and the challenges for health surveillance].

Science.gov (United States)

Soares, Kelen Carine Costa; Moraes, Marcelo Vogler; Gelfuso, Guilherme Martins; Gratieri, Taís

2015-11-01

The comparative evaluation required for the registration of generic topical medicines in Brazil is conducted by means of a pharmaceutical equivalence study, which merely assesses the physical/chemical and microbiological parameters of the formulations. At the international level, clinical or pharmacodynamic studies are now being required to prove the efficacy and safety of semisolid topical generic formulations. This work presents a comparison of the different requirements for the registration of topical formulations, taking into consideration the various regulatory authorities, and presents a survey of topical medicines registered in Brazil prior to 2013. The survey revealed that in comparison with the USA there were many more copies of these formulations registered in Brazil. This fact, together with the large number of studies in the literature showing the lack of bioequivalence of topical medication, is clear proof of the major importance of the need to realign Brazilian legislation with respect to the technical requirements for the registration of generic and similar medication for dermatological topical application in Brazil.

A Comparison of Topical or Retrobulbar Anesthesia for 23-Gauge Posterior Vitrectomy

Directory of Open Access Journals (Sweden)

Hande Celiker

2014-01-01

Full Text Available Background. To compare the efficacy and safety of topical anesthesia versus retrobulbar anesthesia in 23-gauge vitreoretinal surgery. Materials and Methods. A total of 63 patients scheduled for 23 G posterior vitrectomy without scleral buckling procedures were included in the study. The patients were randomly assigned to receive either topical (Group 1, n=31 or retrobulbar anesthesia (Group 2, n=32. Postoperatively, patients were shown a visual analogue pain scale (VAPS from 1 (no pain or discomfort to 4 (severe pain or discomfort to rate the levels of pain. Results. There was more discomfort in patients in Group 2 while anesthetic was administered (Group 1:  1.0±0, Group 2: 2.3±0.7, P=0.0001. Between the two groups the level of pain during surgery (Group 1: 1.4±0.5, Group 2: 1.5±0.5; P=0.85 was noted. There was also no significant difference between two groups postoperatively (Group 1: 1.2±0.4, Group 2: 1.3±0.4; P=0.28. There were no complications in either group related to the anesthetic technique. No patient needed sedation or anesthesia supplement during the surgery or postoperative period. Conclusion. Topical anesthesia in posterior vitrectomy procedures is an effective and safe method that is alternative to retrobulbar anesthesia.

Topical sirolimus for the treatment of angiofibromas in tuberous sclerosis

Directory of Open Access Journals (Sweden)

Salih Levent Cinar

2017-01-01

Full Text Available Background: The skin is one of the most affected organs in tuberous sclerosis complex and angiofibromas are seen in almost 80% of such patients. These benign tumors impose a great psycho-social burden on patients. Objective: The aim of the study was to evaluate the effectiveness and tolerability of topical sirolimus for facial angiofibromas in patients with tuberous sclerosis complex. Methods: This was a prospective, single-blinded, cross-over study which involved twelve patients. We investigated the effect and safety of topical 0.1% sirolimus, which was obtained by crushing sirolimus tablets and mixing it with petrolatum. The patients were asked to apply the cream to one side of their face, and vaseline to the other side. The effect of topical sirolimus was evaluated using the “facial angiofibroma severity index.” Results: There was a significant improvement in the redness and extension of the tumors on the sides to which the active ingredient was applied. Some side effects such as itching and irritation occurred in three patients, which were treated with topical hydrocortisone cream. Conclusion: Topical sirolimus appears to be a promising, fairly well tolerated treatment for facial angiofibromas in patients with tuberous sclerosis complex. Although its efficacy diminishes with time, repetitive usage is effective.

Investigating drug repositioning opportunities in FDA drug labels through topic modeling.

Science.gov (United States)

Bisgin, Halil; Liu, Zhichao; Kelly, Reagan; Fang, Hong; Xu, Xiaowei; Tong, Weida

2012-01-01

Drug repositioning offers an opportunity to revitalize the slowing drug discovery pipeline by finding new uses for currently existing drugs. Our hypothesis is that drugs sharing similar side effect profiles are likely to be effective for the same disease, and thus repositioning opportunities can be identified by finding drug pairs with similar side effects documented in U.S. Food and Drug Administration (FDA) approved drug labels. The safety information in the drug labels is usually obtained in the clinical trial and augmented with the observations in the post-market use of the drug. Therefore, our drug repositioning approach can take the advantage of more comprehensive safety information comparing with conventional de novo approach. A probabilistic topic model was constructed based on the terms in the Medical Dictionary for Regulatory Activities (MedDRA) that appeared in the Boxed Warning, Warnings and Precautions, and Adverse Reactions sections of the labels of 870 drugs. Fifty-two unique topics, each containing a set of terms, were identified by using topic modeling. The resulting probabilistic topic associations were used to measure the distance (similarity) between drugs. The success of the proposed model was evaluated by comparing a drug and its nearest neighbor (i.e., a drug pair) for common indications found in the Indications and Usage Section of the drug labels. Given a drug with more than three indications, the model yielded a 75% recall, meaning 75% of drug pairs shared one or more common indications. This is significantly higher than the 22% recall rate achieved by random selection. Additionally, the recall rate grows rapidly as the number of drug indications increases and reaches 84% for drugs with 11 indications. The analysis also demonstrated that 65 drugs with a Boxed Warning, which indicates significant risk of serious and possibly life-threatening adverse effects, might be replaced with safer alternatives that do not have a Boxed Warning. In

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Directory of Open Access Journals (Sweden)

Mehmet Kamil Mülayim

2016-12-01

Full Text Available Objectives: Oral lichen planus (OLP is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus.

76 FR 78161 - Safety Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2011-12-16

... Zone, Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... INFORMATION: The Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake...

78 FR 40635 - Safety Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-07-08

... Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

78 FR 36092 - Safety Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago...

Science.gov (United States)

2013-06-17

... Zone; Brandon Road Lock and Dam to Lake Michigan Including Des Plaines River, Chicago Sanitary and Ship...; Brandon Road Lock and Dam to Lake Michigan including Des Plaines River, Chicago Sanitary and Ship Canal... Coast Guard will enforce a segment of the Safety Zone; Brandon Road Lock and Dam to Lake Michigan...

The nuclear fuel cycle including essential aspects of safety

International Nuclear Information System (INIS)

Warnemuende, R.; May, H.

1978-11-01

When judging nuclear energy not only the reactor but also the whole fuel cycle is of importance. The fuel cycle consists of the supply, i.e. the process from uranium ore to the insertion of fuel elements into the reactor and the waste management, the removal of fuel elements from the reactor and the final storage of radioactive waste. The different stages of the nuclear fuel cycle are well known with regard to their technical difficulties, their problems of industrial safety and pollution. Although it is possible to compare them qualitatively, they still differ partly to a considerable extent, from a quantitative point of view. However, the fact that technical solutions are available for all kinds of tasks can be stated. It is significant for the Federal Republic of Germany that all essential preparatory work for closing the nuclear fuel cycle has been carried out and that safety problems will no longer be in the way of the large-scale realization of uranium enrichment, reprocessing of nuclear fuels and final storage of radioactive waste. Further research and development activities will serve its technical and economic optimization. (orig.) [de

Additional safety assessments, follow-up of stress tests of the French nuclear power stations. Action plan of the nuclear safety authority

International Nuclear Information System (INIS)

2012-01-01

This document presents the French national action plan defined by the Nuclear Safety Authority (ASN) in compliance with the recommendations made by the ENSREG (European nuclear safety regulators group). It refers to decisions taken at the national level after the Fukushima accident, recommendations after European stress tests, and recommendations after the extraordinary meeting of contracting parties at the Convention on Nuclear Safety of August 2012. For different topics, this document recalls the recommendations made by the peer review, indicates the ASN's opinion and progress or ASN's requirements for different power stations. The first part addresses the recommendations made by peers and based on the European review. Topics concern natural hazards (effects, detection, inspections and controls related to earthquakes, margin assessment with respect to flooding and natural hazards), the loss of safety systems (cooling systems, electricity supplies, actions, instruments, training, and so on), the management of a severe accident (reference levels, measures, guides, exercises, training, management of contaminated water, radiation protection, premises). The second part deals with topics addressed within the frame of the Convention: national organisations, organisations in an emergency and post-accidental situation, international cooperation. A third part addresses the follow-up of additional measures issued by the ASN

Self-assessment of operational safety for nuclear power plants

International Nuclear Information System (INIS)

1999-12-01

Self-assessment processes have been continuously developed by nuclear organizations, including nuclear power plants. Currently, the nuclear industry and governmental organizations are showing an increasing interest in the implementation of this process as an effective way for improving safety performance. Self-assessment involves the use of different types of tools and mechanisms to assist the organizations in assessing their own safety performance against given standards. This helps to enhance the understanding of the need for improvements, the feeling of ownership in achieving them and the safety culture as a whole. Although the primary beneficiaries of the self-assessment process are the plant and operating organization, the results of the self-assessments are also used, for example, to increase the confidence of the regulator in the safe operation of an installation, and could be used to assist in meeting obligations under the Convention on Nuclear Safety. Such considerations influence the form of assessment, as well as the type and detail of the results. The concepts developed in this report present the basic approach to self-assessment, taking into consideration experience gained during Operational Safety Review Team (OSART) missions, from organizations and utilities which have successfully implemented parts of a self-assessment programme and from meetings organized to discuss the subject. This report will be used in IAEA sponsored workshops and seminars on operational safety that include the topic of self-assessment

Nuclear Reactor RA Safety Report, Format and Contents

International Nuclear Information System (INIS)

1986-11-01

This is a new complete version of the safety report of nuclear reactor RA is made according to the recommendations of the IAEA. Report includes all the relevant data needed for evaluation of safe operation of this nuclear facility. Each of seven volumes of this report cover separate topics as follows: (1) introduction; (2) Site characteristics; (3) description of the reactor building and installations; (4) description of the reactor; (5) description of the coolant system; (6) description of the regulation and safety instrumentation; (7) description of the power supply system; (8) description of the auxiliary systems; (9) radiation protection issues; (10) radioactive waste management (11) reactor operation; (12) accident analysis during previous operation; (13) analysis of possible accident causes; (14) safety analysis and preventive actions: (15) analysis of significant accidents; (16) analysis of maximum possible accident; (17) environmental impact analysis in case of accident [sr

Topics in modern differential geometry

CERN Document Server

Verstraelen, Leopold

2017-01-01

A variety of introductory articles is provided on a wide range of topics, including variational problems on curves and surfaces with anisotropic curvature. Experts in the fields of Riemannian, Lorentzian and contact geometry present state-of-the-art reviews of their topics. The contributions are written on a graduate level and contain extended bibliographies. The ten chapters are the result of various doctoral courses which were held in 2009 and 2010 at universities in Leuven, Serbia, Romania and Spain.

Key Topics in Sports Medicine

OpenAIRE

2006-01-01

Key Topics in Sports Medicine is a single quick reference source for sports and exercise medicine. It presents the essential information from across relevant topic areas, and includes both the core and emerging issues in this rapidly developing field. It covers: 1) Sports injuries, rehabilitation and injury prevention, 2) Exercise physiology, fitness testing and training, 3) Drugs in sport, 4) Exercise and health promotion, 5) Sport and exercise for special and clinical populations, 6) The ps...

Nuclear safety policy working group recommendations on nuclear propulsion safety for the space exploration initiative

Science.gov (United States)

Marshall, Albert C.; Lee, James H.; Mcculloch, William H.; Sawyer, J. Charles, Jr.; Bari, Robert A.; Cullingford, Hatice S.; Hardy, Alva C.; Niederauer, George F.; Remp, Kerry; Rice, John W.

1993-01-01

An interagency Nuclear Safety Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program. These recommendations, which are contained in this report, should facilitate the implementation of mission planning and conceptual design studies. The NSPWG has recommended a top-level policy to provide the guiding principles for the development and implementation of the SEI nuclear propulsion safety program. In addition, the NSPWG has reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. These recommendations should be useful for the development of the program's top-level requirements for safety functions (referred to as Safety Functional Requirements). The safety requirements and guidelines address the following topics: reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations.

Topical colloidal silver as an anti-biofilm agent in a Staphylococcus aureus chronic rhinosinusitis sheep model.

Science.gov (United States)

Rajiv, Sukanya; Drilling, Amanda; Bassiouni, Ahmed; James, Craig; Vreugde, Sarah; Wormald, Peter-John

2015-04-01

Treatment of recalcitrant chronic rhinosinusitis (CRS) is a challenge with increasing antibiotic resistance, leading to re-emergence of topical therapies. The aim of this study was to assess safety and efficacy of topical colloidal silver solution for the treatment of Staphylococcus aureus biofilms in a sheep model. In the safety study, normal saline (control) and 30-ppm colloidal silver solution (test) was used to flush the frontal sinuses for 14 days in 8 sheep (4 sheep each). In the efficacy study, following frontal sinus infection with Staphylococcus aureus, sheep were treated with either control saline or topical silver solution of varying concentrations (30 ppm/20 ppm/10 ppm/5 ppm) for 5 days, with 4 sheep in each group. Blood silver level, full blood counts, and biochemical parameters were analyzed in both safety and efficacy studies. Sinus tissue was harvested for histological examination and ciliary structure analysis in safety and for biofilm biomass quantification by fluorescence in situ hybridization (FISH) technique and COMSTAT 2 software in the efficacy study. Results were analyzed using appropriate statistical tests. Sheep treated with silver showed a significant decrease in biofilm biomass (0.004, 0.004, 0.004, and 0.007, in the 4 silver-treated groups, respectively) compared to saline control (0.175), p silver levels were higher in the treated groups compared to controls (p colloidal silver solution has effective antibiofilm activity in Staphylococcus aureus CRS in a sheep model and appears safe. © 2015 ARS-AAOA, LLC.

Regulatory oversight report 2008 concerning nuclear safety in Swiss nuclear installations; Aufsichtsbericht 2008 ueber die nukleare Sicherheit in den schweizerischen Kernanlagen

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-04-15

This annual report issued by the Swiss Federal Nuclear Inspectorate (ENSI) reports on the work carried out by the Inspectorate in 2008. This report reviews the regulatory activities in the four Swiss nuclear power stations and in four further nuclear installations in various Swiss research facilities. It deals with topics such as operational details, technologies in use, radiation protection, radioactive wastes, emergency dispositions, personnel and provides an assessment of operations from the safety point of view. Also, the transportation of nuclear materials - both nuclear fuels and nuclear wastes - is reported on. General topics discussed include probabilistic safety analyses and accident management, earthquake damage analysis and agreements on nuclear safety. The underground disposal of highly-radioactive nuclear wastes and work done in the rock laboratories are discussed, as are proposals for additional nuclear power stations.

Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687.

Directory of Open Access Journals (Sweden)

Catarina Soares Queirós

2017-03-01

Full Text Available Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.

Safety of nuclear installations: Future direction

International Nuclear Information System (INIS)

1990-04-01

The Workshop presentations were divided into sessions devoted to the following topics: Environmental impact of fossil fuel energy technologies (5 papers), Future needs for nuclear power (7 papers), Safety objectives (10 papers), Safety aspects of the next generation of current-type nuclear power plants (8 papers), Safety aspects of new designs and concepts for nuclear power plants (6 papers), Special safety issues: Safety aspects of new designs and concepts for nuclear power plants (5 papers), Safety aspects of new designs and processes for the nuclear fuel cycle (5 papers), Closing panel (3 papers), 12 poster presentations and a Summary of the Workshop. A separate abstract was prepared for each of these papers. Refs, figs and tabs

Occupational Safety & Health. Inspectors' Opinions on Improving OSHA Effectiveness. Fact Sheet for Subcommittee on Health and Safety, Committee on Education and Labor, House of Representatives.

Science.gov (United States)

General Accounting Office, Washington, DC. Div. of Human Resources.

Questionnaires gathered opinions of all Occupational Safety and Health Administration (OSHA) field supervisors and a randomly selected sample of one-third of the compliance officers about OSHA's approach to improving workplace safety and health. Major topics addressed were enforcement, safety and health standards, education and training, employer…

NEA/IAEA Workshop on Leadership and Management for Safety. ONR approach

International Nuclear Information System (INIS)

Harvey, Paul

2012-01-01

Paul Harvey summarised the progress made by the UK ONR on oversight of LMfS since the previous workshop in 2007. The ONR approach is based on published Safety Assessment Principles (SAPs) on Leadership and Management for Safety. The four principles cover Leadership, Capable Organisation, Decision Making and Learning. Safety culture is embodied within the LMfS SAPs/strategy rather than being treated as a specific topic. The ONR LMfS strategy draws on the lessons from major events (e.g., Texas City, Davis Besse, Columbia) and includes integration of LMfS into existing types of regulatory interventions. Key elements of the strategy include more attention to organisational and cultural factors, increased focus on Board/Director/Executive Team levels in licensees, more focus on how licensees oversee themselves, and improving ONR ability to identify precursors and influencing in combination with regulation. Guidance on Leadership and Management for safety has been produced and is undergoing trial use by ONR inspectors. The guidance is structured around the four LMfS safety assessment principles. It provides help on what to look for during interactions with licensees. ONR staff record significant points (both potential concerns and good practices) in their Intervention Reports under the 'LMfS' heading. This should enable ONR to build up a picture of strengths and weaknesses and plan interventions. Workshops on LMfS have been held for inspectors and managers. These cover organisational and cultural lessons from a range of major events and relate these to ONR LMfS strategy and draft guidance. Other interventions which form part of the strategy include 'deep slice' inspections on specific LMfS topics, and interactions with some licensee Company Boards on lessons from major events and the ONR LMfS strategy. These have been received positively by licensees. It was concluded that ongoing effort is needed to fully implement and embed the ONR LMfS strategy

Development and Evaluation of Topical Gabapentin Formulations

Science.gov (United States)

Alcock, Natalie; Hiom, Sarah; Birchall, James C.

2017-01-01

Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have been variable and dependent on the skin model employed, primarily involving rodent and porcine models. In this study a variety of topical gabapentin formulations were investigated, including Carbopol® hydrogels containing various permeation enhancers, and a range of proprietary bases including a compounded Lipoderm® formulation; furthermore microneedle facilitated delivery was used as a positive control. Critically, permeation of gabapentin across a human epidermal membrane in vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised within the wider scope of the literature. Although reports of topical gabapentin delivery have been shown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w) gabapentin 0.75% (w/w) Carbopol® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol and a compounded 10% (w/w) gabapentin Lipoderm® formulation were able to facilitate permeation of the molecule across human skin. Further pre-clinical and clinical studies are required to investigate the topical delivery performance and pharmacodynamic actions of prospective formulations. PMID:28867811

Key practical issues in strengthening safety culture. INSAG-15. A report by the International Safety Advisory Group

International Nuclear Information System (INIS)

2002-01-01

This report describes the essential practical issues to be considered by organizations aiming to strengthen safety culture. It is intended for senior executives, managers and first line supervisors in operating organizations. Although safety culture cannot be directly regulated, it is important that members of regulatory bodies understand how their actions affect the development of attempts to strengthen safety culture and are sympathetic to the need to improve the less formal human related aspects of safety. The report is therefore of relevance to regulators, although not intended primarily for them. The International Nuclear Safety Advisory Group (INSAG) introduced the concept of safety culture in its INSAG-4 report in 1991. Since then, many papers have been written on safety culture, as it relates to organizations and individuals, its improvement and its underpinning prerequisites. Variations in national cultures mean that what constitutes a good approach to enhancing safety culture in one country may not be the best approach in another. However, INSAG seeks to provide pragmatic and practical advice of wide applicability in the principles and issues presented in this report. Nuclear and radiological safety are the prime concerns of this report, but the topics discussed are so general that successful application of the principles should lead to improvements in other important areas, such as industrial safety, environmental performance and, in some respects, wider business performance. This is because many of the attitudes and practices necessary to achieve good performance in nuclear safety, including visible commitment by management, openness, care and thoroughness in completing tasks, good communication and clarity in recognizing major issues and dealing with them as a priority, have wide applicability

Safety valve including a hydraulic brake and hydraulic brake that could be fitted into a valve

International Nuclear Information System (INIS)

Chabat-Courrede, Jean.

1981-01-01

Making of a safety valve that can be fitted to a containment vessel filled with a non compressible fluid, such as the water system of a nuclear power station. It includes a hydraulic brake located between the valve and the elastic means, close to the valve which completely suppresses the high frequency oscillations of the equipment [fr

Asymptotic safety, emergence and minimal length

International Nuclear Information System (INIS)

Percacci, Roberto; Vacca, Gian Paolo

2010-01-01

There seems to be a common prejudice that asymptotic safety is either incompatible with, or at best unrelated to, the other topics in the title. This is not the case. In fact, we show that (1) the existence of a fixed point with suitable properties is a promising way of deriving emergent properties of gravity, and (2) there is a sense in which asymptotic safety implies a minimal length. In doing so we also discuss possible signatures of asymptotic safety in scattering experiments.

Antibacterial drugs in the form of sprays for the topical treatment of pyodermas and dermatoses complicated with a secondary infection

Directory of Open Access Journals (Sweden)

YE. V. Matushevskaya

2014-01-01

Full Text Available The article covers issues related to the application of topical antibacterial drugs for the treatment of pyodermic skin diseases. The author describes mechanisms of action and advantages of the topical form of antibiotics and GCS for the topical treatment of pyodermas. The article substantiates indications for the administration of topical GCS drugs in a combination with antibacterial drugs. The efficacy and safety of antibacterial and combination topical drugs such as Neomycin, Oxycort and Polcortolon TC in the form sprays for the treatment of pyodermas and complicated forms of chronic dermatosis.

Topics in quantum theory

International Nuclear Information System (INIS)

Yuille, A.L.

1980-11-01

Topics in the Yang-Mills theories of strong interactions and the quantum theories of gravity are examined, using the path integral approach, including; Yang-Mills instantons in curved spacetimes, Israel-Wilson metrics, Kaehler spacetimes, instantons and anti-instantons. (U.K.)

Nuclear safety in France

International Nuclear Information System (INIS)

Servant, J.

1979-12-01

The main areas of nuclear safety are considered in this paper, recalling the laws and resolutions in force and also the appropriate authority in each case. The following topics are reviewed: radiological protection, protection of workers, measures to be taken in case of an accident, radioactive effluents, impact on the environment of non-nuclear pollution, nuclear plant safety, protection against malicious acts, control and safeguard of nuclear materials, radioisotopes, transport of radioactive substances, naval propulsion, waste management, nuclear plant decommissioning and export of nuclear equipment and materials. Finally, the author describes the role of the general Secretariat of the Interdepartmental Committee on Nuclear Safety

International conference on the operational safety performance in nuclear installations. Contributed papers

International Nuclear Information System (INIS)

2005-01-01

In 2001, the IAEA organized an 'International Conference on Topical Issues in Nuclear Safety'. The issues discussed during the conference were: (1) risk- informed decision-making; (2) influence of external factors on safety; (3) safety of fuel cycle facilities; (4) safety of research reactors; and (5) safety performance indicators. Senior nuclear safety decision makers reviewed the issues and formulated recommendations for future actions by national and international organizations. In 2004, the IAEA organized an 'International Conference on Topical Issues in Nuclear Safety' in Beijing China. The issues discussed during the conference were: (1) changing environment - coping with diversity and globalization; (2) operating experience - managing changes effectively; (3) regulatory management systems - adapting to changes in the environment; and (4) long term operations - maintaining safety margins while extending plant lifetimes. The results of this conference confirmed the importance of operators and regulators of nuclear facilities meeting periodically to share experience and opinion on emerging issues and future challenges of the nuclear industry. Substantial progress has been made, and continues to be made by Member States in enhancing the safety of nuclear installations worldwide. At the same time, more attention is being given to other areas of nuclear safety. The safety standards for research reactors are being updated and new standards are planned on the safety of other facilities in the nuclear fuel cycle. The Agency has taken a lead role in this effort and is receiving much support from its Member States to gain international consensus in these areas. The objective of the conference is to foster the exchange of information on operational safety performance and operating experience in nuclear installations, with the aim of consolidating an international consensus on: - the present status of these issues; - emerging issues with international implications

Earthquakes and associated topics in relation to nuclear power plant siting

International Nuclear Information System (INIS)

1991-01-01

This Safety Guide was prepared as part of the Agency's programme for establishing Codes and Safety Guides relating to nuclear power plants. The main purpose of the text is to provide guidance on the determination of the design basis ground motions for a nuclear power plant at a chosen site and on the determination of the potential for surface faulting at that site. Additionally, the Guide discusses other permanent displacement phenomena (liquefaction, slope instability, subsidence and collapse) and introduces the topic of seismically induced flooding. Volcanic activity is not dealt with except in connection with tsunamis. 55 refs

Pooled analysis of clinical trial data evaluating the safety and effectiveness of diclofenac epolamine topical patch 1.3% for the treatment of acute ankle sprain

Directory of Open Access Journals (Sweden)

Lionberger DR

2011-07-01

Full Text Available David R Lionberger1, Eric Joussellin2, Jillmarie Yanchick3, Merrell Magelli3,4, Arturo Lanzarotti51Southwest Orthopedic Group, LLP, Houston, TX, USA; 2Institut National du Sport, Paris, France; 3Formerly Alpharma Pharmaceuticals LLC, Piscataway, NJ, USA; 4GTx, Inc., Memphis, TN, USA; 5Institut Biochimique SA, SwitzerlandAbstract: This pooled analysis assessed the efficacy and safety of the diclofenac epolamine topical patch 1.3% (DETP for the treatment of acute mild-to-moderate ankle sprain. Data from 2 randomized, double-blind, placebo-controlled studies enrolling 274 male and female patients aged 18 to 65 years with acute ankle sprain were pooled and evaluated. The primary end point was pain reduction on movement assessed using a 100 mm visual analog scale (VAS. Safety and tolerability were also assessed. Beginning approximately 3 hours after initial treatment, DETP-treated patients experienced statistically significant and sustained lower mean VAS scores in pain intensity on movement (mean ± SD, 54.1 ± 20.0 mm versus 60.3 ± 16.8 mm compared with placebo-treated patients, representing a 20% versus 13% reduction in VAS pain scores from baseline (P = 0.012. This statistically significant difference in mean VAS score was maintained through day 7 (9.4 ± 14.4 mm versus 18.4 ± 18.2 mm, P < 0.0001. The DETP and placebo patches were well tolerated. These results further confirm the efficacy and safety of DETP for the treatment of acute pain from ankle sprains.Keywords: soft tissue injury, acute pain, visual analog scale, clinical trial, double-blind, safety

Seismic safety of nuclear power plants in Eastern Europe

International Nuclear Information System (INIS)

Gurpinar, A.; Godoy, A.

1995-01-01

This paper summarizes the work performed by the International Atomic Energy Agency in the areas of safety reviews and applied research in support of programmes for the assessment and enhancement of seismic safety in WWER type nuclear power plants during the past five years. Three major topics are discussed; engineering safety review services in relation to external events, technical guidelines for the assessment and upgrading of WWER type nuclear power plants, and the Coordinated Research Programme on B enchmark study for the seismic analysis and testing of WWER type nuclear power plants . These topics are summarized in a way to provide an overview of the past and present safety situation in selected WWER type plants which are all located in Eastern European countries. Main conclusion of the paper is that although there is now a thorough understanding of the seismic safety issues in these operating nuclear power plants, the implementation of seismic upgrades to structures, systems and components are lagging behind, particularly for those cases in which the re-evaluation indicated the necessity to strengthen the safety related structures or install new safety systems. (author)

Summary of Tiger Team Assessment and Technical Safety Appraisal recurring concerns in the Operations Area

International Nuclear Information System (INIS)

1993-01-01

Fourteen Tiger Team Assessment and eight Technical Safety Appraisal (TSA) final reports have been received and reviewed by the DOE Training Coordination Program during Fiscal Year 1992. These assessments and appraisals included both reactor and non-reactor nuclear facilities in their reports. The Tiger Team Assessments and TSA reports both used TSA performance objectives, and list ''concerns'' as a result of their findings. However, the TSA reports categorized concerns into the following functional areas: (1) Organization and Administration, (2) Radiation Protection, (3) Nuclear Criticality Safety, (4) Occupational Safety, (5) Engineering/Technical Support, (6) Emergency Preparedness, (7) Safety Assessments, (8) Quality Verification, (9) Fire Protection, (10) Environmental Protection, and (11) Energetic Materials Safety. Although these functional areas match most of the TSA performance objectives, not all of the TSA performance objectives are addressed. For example, the TSA reports did not include Training, Maintenance, and Operations as functional areas. Rather, they included concerns that related to these topics throughout the 11 functional areas identified above. For consistency, the Operations concerns that were identified in each of the TSA report functional areas have been included in this summary with the corresponding TSA performance objective

SAFETY IN THE DESIGN OF SCIENCE LABORATORIES AND BUILDING CODES.

Science.gov (United States)

HOROWITZ, HAROLD

THE DESIGN OF COLLEGE AND UNIVERSITY BUILDINGS USED FOR SCIENTIFIC RESEARCH AND EDUCATION IS DISCUSSED IN TERMS OF LABORATORY SAFETY AND BUILDING CODES AND REGULATIONS. MAJOR TOPIC AREAS ARE--(1) SAFETY RELATED DESIGN FEATURES OF SCIENCE LABORATORIES, (2) LABORATORY SAFETY AND BUILDING CODES, AND (3) EVIDENCE OF UNSAFE DESIGN. EXAMPLES EMPHASIZE…

Safety Design Approach for the Development of Safety Requirements for Design of Commercial HTGR

International Nuclear Information System (INIS)

Ohashi, Hirofumi; Sato, Hiroyuki; Nakagawa, Shigeaki; Tachibana, Yukio; Nishihara, Tetsuo; Yan, Xing; Sakaba, Nariaki; Kunitomi, Kazuhiko

2014-01-01

The research committee on “Safety requirements for HTGR design” was established in 2013 under the Atomic Energy Society of Japan to develop the draft safety requirements for the design of commercial High Temperature Gas-cooled Reactors (HTGRs), which incorporate the HTGR safety features demonstrated using the High Temperature Engineering Test Reactor (HTTR), lessons learned from the accident of Fukushima Daiichi Nuclear Power Station and requirements for the integration of the hydrogen production plants. The safety design approach for the commercial HTGRs which is a basement of the safety requirements is determined prior to the development of the safety requirements. The safety design approaches for the commercial HTGRs are to confine the radioactive materials within the coated fuel particles not only during normal operation but also during accident conditions, and the integrity of the coated fuel particles and other requiring physical barriers are protected by the inherent and passive safety features. This paper describes the main topics of the research committee, the safety design approaches and the safety functions of the commercial HTGRs determined in the research committee. (author)

Topical tags vs non-topical tags : Towards a bipartite classification?

NARCIS (Netherlands)

Basile, Valerio; Peroni, Silvio; Tamburini, Fabio; Vitali, Fabio

2015-01-01

In this paper we investigate whether it is possible to create a computational approach that allows us to distinguish topical tags (i.e. talking about the topic of a resource) and non-topical tags (i.e. describing aspects of a resource that are not related to its topic) in folksonomies, in a way that

Regulatory oversight of safety culture in nuclear installations - New IAEA developments

International Nuclear Information System (INIS)

Kerhoas, Anne; )

2012-01-01

Ms. Anne Kerhoas described the IAEA work on guidance for regulatory oversight of safety culture. She summarised the various IAEA, OECD/NEA and ANS meetings that have been held on the topic between 1995 and 2011. The IAEA has carried out two recent projects with the Bulgarian and Romanian regulatory bodies to develop a safety culture oversight program. The work was funded by the Norwegian government and has involved 30 experts from 17 different countries. Draft guidance for regulators on how to monitor licensee safety culture has also been produced (IAEA-TECDOC-DD1070). The document is intended to provide practical guidance on oversight strategies and is applicable to a wide range of nuclear installations, including nuclear power plants, fuel cycle facilities, research reactors and waste management facilities. A number of principles for regulatory oversight of safety culture were summarised. For example, the primary responsibility for safety remains with the licensee, safety culture oversight should be performed at all stages of the life cycle of the nuclear installation, and multiple data collection methods should be used. The overall approach to safety culture described in the draft IAEA Tech doc includes a range of approaches to build up a meaningful picture of the licensee's safety culture. These include interviews, observations, review of documents, review of events, discussions and surveys. The importance of ongoing discussion with the licensee throughout the process to develop a deeper shared understanding of issues was emphasised. The results of the Chester 2 workshop will be used as an input to finalization of the draft Tech Doc

Topics in millimeter wave technology

CERN Document Server

Button, Kenneth

1988-01-01

Topics in Millimeter Wave Technology, Volume 1 presents topics related to millimeter wave technology, including fin-lines and passive components realized in fin-lines, suspended striplines, suspended substrate microstrips, and modal power exchange in multimode fibers. A miniaturized monopulse assembly constructed in planar waveguide with multimode scalar horn feeds is also described. This volume is comprised of five chapters; the first of which deals with the analysis and synthesis techniques for fin-lines as well as the various passive components realized in fin-line. Tapers, discontinuities,

Safety and environmental aspects of deuterium--tritium fusion power plants: work shop summary

International Nuclear Information System (INIS)

1978-05-01

In September of 1977 a workshop was held on the safety and environmental aspects of fusion power plants to consider potential safety and environmental problems of fusion power plants and to reveal solutions or methods of solving those problems. The objective was to promote incorporation of safety and environmental protection into reactor design, thereby reducing the expense and delay of backfitting safety systems after reactor designs are complete. A dialogue was established between fusion reactor designers and safety and environmental researchers. Four topics, each with several subdivisions, were selected for discussion: radiation exposure, accidents, environmental effects, and plant safety. For each topic, discussion focused on the significance of the problem, and adequacy of current technology to solve the problem, design solutions available and research needed to solve the problem

Special characteristics of the safety analysis of HWRs