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Sample records for sabine merten antoni

  1. An Apology for Antony

    DEFF Research Database (Denmark)

    Kluge, Sofie

    2008-01-01

    of the great Mark Antony's downfall through moral corruption - that Shakespeare inherited from Roman historiography through Plutarch's Life of Antony, Medieval historiography, and Renaissance emblematics. In contrast to the recent critical negligence of the moral aspect of the play, as well as the overemphasis...

  2. Cheetham, Prof. Antony Kevin

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Cheetham, Prof. Antony Kevin FRS. Date of birth: 16 November 1946. Address: Dept. of Materials Science &, Metallurgy, University of Cambridge, 27, Charles Babbage Road, Cambridge CB3 0FS, uk. Contact: Office: (+44-1223) 74 6733. Fax: (+44-1223) 33 4567

  3. Med Antony Beevor i Ardennerne

    DEFF Research Database (Denmark)

    Christensen, Claus Bundgård

    2015-01-01

    Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten.......Den storsælgende amerikanske historiker Antony Beevor tager i sin gennemgang af Anden Verdenskrigs slag denne gang læserne med til de sneklædte skove i Ardennerne, hvor tyskerne iværksatte deres sidste store offensiv på Vestfronten....

  4. Antoni Pous, poeta i traductor

    OpenAIRE

    Farrés Puntí, Ramon

    2002-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Antoni Pous, poeta i traductor és un estudi monogràfic de la figura d'Antoni Pous i Argila (Manlleu, 1932 - Barcelona, 1976), activista cultural i home de lletres que va destacar de molt jove, en la immediata postguerra, com a poeta de gran talent; que als anys seixanta va dur a terme una tasca cultural i pedagògica de gran transcendència a Igualada, amb la fundació del grup Lacetània i la creació de la revista Textos; q...

  5. Neuroprotective Effect of Sargassum thunbergii (Mertens ex Roth ...

    African Journals Online (AJOL)

    Purpose: To evaluate the anti-oxidant and anti-neuroinflammatory effects of the Sargassum thunbergii extract (Mertens ex Roth) Kuntze (STE) in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells in vitro. Methods: STE antioxidative activity was evaluated with an Electron Spin Resonance (ESR) spectrometer, which ...

  6. Learning from eponyms: Jose Verocay and Verocay bodies, Antoni A and B areas, Nils Antoni and Schwannomas

    Directory of Open Access Journals (Sweden)

    Rajiv Joshi

    2012-01-01

    Full Text Available Schwannomas are benign peripheral nerve sheath neoplasms composed almost entirely of Schwann cells and are diagnosed histopathologically by the presence of singular architectural patterns called Antoni A and Antoni B areas. These were described first in 1920 by the Swedish neurologist Nils Antoni. The Antoni A tissue is highly cellular and made up of palisades of Schwann cell nuclei, a pattern first described in 1910 by the Uruguayan neuro-pathologist Jose Verocay and are known as Verocay bodies. This article describes the structure and appearance of Verocay bodies and Antoni A and B areas with a brief biographical introduction of the men who described these patterns.

  7. A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome

    NARCIS (Netherlands)

    Rutsch, Frank; Macdougall, Mary; Lu, Changming; Buers, Insa; Mamaeva, Olga; Nitschke, Yvonne; Rice, Gillian I.; Erlandsen, Heidi; Kehl, Hans Gerd; Thiele, Holger; Nürnberg, Peter; Höhne, Wolfgang; Crow, Yanick J.; Feigenbaum, Annette; Hennekam, Raoul C.

    2015-01-01

    Singleton-Merten syndrome (SMS) is an infrequently described autosomal-dominant disorder characterized by early and extreme aortic and valvular calcification, dental anomalies (early-onset periodontitis and root resorption), osteopenia, and acro-osteolysis. To determine the molecular etiology of

  8. Estudi dels exempla als Avisos de sant Antoni Maria Claret

    Directory of Open Access Journals (Sweden)

    Hèctor Sanchis Mollà

    2014-12-01

    Full Text Available La literatura religiosa del segle XIX ha estat poc tractada pels estudiosos. En el present treball, analitzarem un dels recursos per excel·lència d’aquesta literatura, és a dir, l’exemplum. En concret, esbrinarem la font dels exempla utilitzats per sant Antoni Maria Claret a les obres: Avisos saludables a las donsellas (1850, Avisos molt útils á las viudas (1848, Avisos molt útils als pares de familia (1845 i Avisos saludables als noys (1851. A més, indicarem si els exempla han estat utilitzats per altres autors contemporanis al nostre. The religious literature of the nineteenth century has been recently treated by scholars. In this paper, we discuss a resource par excellence of this literature: the exemplum. In particular, we find out the source of the examples used by St. Antoni Maria Claret works: Avisos saludables a las donsellas (1850, Avisos molt útils á las viudas (1848, Avisos molt útils als pares de familia (1845 i Avisos saludables als noys (1851. Also, we indicate if the examples have been used by other contemporary authors. Keywords: exemplum; saint

  9. Biographical narrative in relation to Great History : Les éblouissements by Pierre Mertens

    Directory of Open Access Journals (Sweden)

    Jerzy Lis

    2012-01-01

    Full Text Available Pierre Mertens’ novel Les éblouissements, published in 1987, is a fictionalised biography of a famous German poet Gottfried Benn, who made the biggest mistake of his life agreeing to support the National Socialist regime during several months. Mertens reconstructs the poet’s life trying to understand the reasons of his commitment, considered by the intellectuals of that time to be a betrayal. Mertens’ text is an illustration of the relationship between the individual and the historical past and, at the same time, an example of problemising the biographical factor in relation to Great History. Playing with the double signification of the word ‘éblouissement’, the novelist offers his own interpretation of the German poet’s double life.

  10. 76 FR 52563 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2011-08-23

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary... Regulations; Sabine River, Orange, TX in the Federal Register (76 FR 103). We received no comments on the... Regulations for Marine Events; Sabine River, Orange, TX. (a) Definitions. As used in this section...

  11. 75 FR 41119 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2010-07-15

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of... the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local... Orange, TX, Thunder on the Sabine boat races. The powerboat race and associated testing will occur...

  12. Environmental Project of I.E.S. Antoni Maura

    Science.gov (United States)

    Crespi Salom, Pere

    2010-05-01

    Environmental Project of I.E.S. Antoni Maura Author(s): Pere Crespí i Salom Teacher of Department of Biology and Geology and Environmental Coordinator (2009-2010) from I.E.S. Antoni Maura . Mallorca. Illes Balears. Spain Teachers participating in the project : Myriam Fuentes Milani, Olga Ballester Nebot, Antoni Salom Ruiz, Julio René Loayza Casanova, Puy Aguirre Rémirez, Yolanda Martínez Laserna, Jaume Puppo Lama, Carme Arrom , Dolors Aguiló Segura, Marga Ordinas Boter, Angel Fernàndez Albertí , Immaculada Suau López, Antònia Florit Torrandell, Isabel Mateu Arcos, Román Piña Valls i Pere Crespí Salom. Our institute takes part since 2004 in adapting environmentally the schools in the Balearics which consists of developing activities which aim is that both teachers and students acquire habits so as to apply to their ordinary lives though different participative commissions ( 10-15 teachers): 1st commission: recycling and reusing materials. Enough bins in the classrooms and floors: yellow for plastic, blue for paper, and green for the other. We tend to use recycled materials in different celebrations such as Carnival, Christmas, Saint Jordi and Environmental day. We also organise workshops for the teachers to develop afterwards with the students and nature of environmental exposures. 2nd commission: Scatter information ( MonMaura, Maurifull, Green window and website).Throughout different means we inform the teachers and students about all the school activities and where to consult.( www.iesantonimaura.net, Playful area , environmental project ). 3rd commission: Reusing text books.( there is a students service of borrowing books and giving them back at the end of the school year if the book is in good use.) 4th commission: Improving the school surroundings, the back garden and garden with native plants. Department of Biology and Geology is responsible for caring for an organic garden and in turn improve the center's garden with native plants within the

  13. RIG-I-Like Receptor Signaling in Singleton-Merten Syndrome

    Directory of Open Access Journals (Sweden)

    Changming Lu

    2017-09-01

    Full Text Available Singleton-Merten syndrome (SMS is an autosomal dominant, multi-system innate immune disorder characterized by early and severe aortic and valvular calcification, dental and skeletal abnormalities, psoriasis, glaucoma, and other varying clinical findings. Recently we identified a specific gain-of-function mutation in IFIH1, interferon induced with helicase C domain 1, segregated with this disease. SMS disease without hallmark dental anomalies, termed atypical SMS, has recently been reported caused by variants in DDX58, DEXD/H-box helicase 58. IFIH1 and DDX58 encode retinoic acid-inducible gene I (RIG-I-like receptors family members melanoma differentiation-associated gene 5 and RIG-I, respectively. These cytosolic pattern recognition receptors function in viral RNA detection initiating an innate immune response through independent pathways that promote type I and type III interferon expression and proinflammatory cytokines. In this review, we focus on SMS as an innate immune disorder summarizing clinical features, molecular aspects of the pathogenetic pathway and discussing underlying mechanisms of the disease.

  14. Sabin and wild type polioviruses from children who presented with ...

    African Journals Online (AJOL)

    Conclusion: This study further confirms the presence of Sabin and wild-type poliovirus among children in Nigeria. The isolation of Sabin strain of poliovirus is advantageous to the polio eradication program as it is capable of inducing natural immunity in susceptible hosts. Transmission of wild-type poliovirus among children ...

  15. 75 FR 55968 - Special Local Regulations, Sabine River; Orange, TX

    Science.gov (United States)

    2010-09-15

    ...-AA08 Special Local Regulations, Sabine River; Orange, TX AGENCY: Coast Guard, DHS. ACTION: Temporary... Arthur Captain of the Port Zone on the Sabine River, Orange, Texas. This Special Local Regulation is... River, Orange, TX in the Federal Register (75 FR 41119). We received no comments on the proposed rule...

  16. 76 FR 30890 - Special Local Regulations; Sabine River, Orange, TX

    Science.gov (United States)

    2011-05-27

    ...-AA08 Special Local Regulations; Sabine River, Orange, TX AGENCY: Coast Guard, DHS. ACTION: Notice of... the Port Arthur Captain of the Port Zone on the Sabine River, Orange, Texas on September 24-25, 2011... race in conjunction with the Orange, TX S.P.O.R.T. boat races. The powerboat race and associated...

  17. Education under the Heel of Caesar: Reading UK Higher Education Reform through Shakespeare's "Antony and Cleopatra"

    Science.gov (United States)

    Ward, Sophie

    2012-01-01

    UK higher education reform (BIS, ) has been presented as a common-sense movement towards efficiency. This article will argue that, in reality, the marketisation of higher education is a movement towards negative freedom, defined after Berlin (2007) as unrestricted choice. Using Shakespeare's "Antony and Cleopatra" as a means to explore…

  18. Antony van Leeuwenhoek's microscopes and other scientific instruments: new information from the Delft archives

    NARCIS (Netherlands)

    Zuidervaart, Huib J.

    2016-01-01

    This paper discusses the scientific instruments made and used by the microscopist Antony van Leeuwenhoek (1632–1723). The immediate cause of our study was the discovery of an overlooked document from the Delft archive: an inventory of the possessions that were left in 1745 after the death of

  19. National Status and Trends: Bioeffects Program - Sabine Lake, Texas Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The toxicity of sediments in Sabine Lake, Texas, and adjoining Intracoastal Waterway canals was determined as part of bioeffects assessment studies managed by NOAA's...

  20. Bio-Inspired Design Approach Analysis: A Case Study of Antoni Gaudi and Santiago Calatrava

    OpenAIRE

    Marzieh Imani

    2017-01-01

    Antoni Gaudi and Santiago Calatrava have reputation for designing bio-inspired creative and technical buildings. Even though they have followed different independent approaches towards design, the source of bio-inspiration seems to be common. Taking a closer look at their projects reveals that Calatrava has been influenced by Gaudi in terms of interpreting nature and applying natural principles into the design process. This research firstly discusses the dialogue between Biomimicry and archit...

  1. Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria.

    Science.gov (United States)

    Famulare, Michael; Chang, Stewart; Iber, Jane; Zhao, Kun; Adeniji, Johnson A; Bukbuk, David; Baba, Marycelin; Behrend, Matthew; Burns, Cara C; Oberste, M Steven

    2016-01-01

    To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studied molecular evolution in Sabin-like poliovirus isolates from Nigerian acute flaccid paralysis cases obtained from routine surveillance. We employed a novel modeling approach to infer substitution and recombination rates from whole-genome sequences and information about poliovirus infection dynamics and the individual vaccination history. We confirmed observations from a recent vaccine trial that VP1 substitution rates are increased for Sabin-like isolates relative to the rate for the wild type due to increased nonsynonymous substitution rates. We also inferred substitution rates for attenuating nucleotides and confirmed that reversion can occur in days to weeks after vaccination. We combine our observations for Sabin-like virus evolution with the molecular clock for VP1 of circulating wild-type strains to infer that the mean time from the initiating vaccine dose to the earliest detection of circulating vaccine-derived poliovirus (cVDPV) is 300 days for Sabin-like virus type 1, 210 days for Sabin-like virus type 2, and 390 days for Sabin-like virus type 3. Phylogenetic relationships indicated transient local transmission of Sabin-like virus type 3 and, possibly, Sabin-like virus type 1 during periods of low wild polio incidence. Comparison of Sabin-like virus recombinants with known Nigerian vaccine-derived poliovirus recombinants shows that while recombination with non-Sabin enteroviruses is associated with cVDPV, the recombination rates are similar for Sabin isolate-Sabin isolate and Sabin isolate-non-Sabin enterovirus recombination after accounting for the time from dosing to the time of detection. Our study provides a comprehensive picture of the evolutionary dynamics of the oral polio vaccine in the field. The global polio eradication effort has completed its 26th year. Despite success in eliminating wild poliovirus from most of the world, polio persists in populations

  2. 76 FR 63914 - Sabine River Authority of Texas and Sabine River Authority, State of Louisiana; Notice of...

    Science.gov (United States)

    2011-10-14

    ...-foot-high powerhouse located in the right abutment, containing two vertical Kaplan turbines with an... adjacent to the powerhouse. The Sabine River Authorities propose to construct a 1.3-MW minimum flow turbine...

  3. Comparison of ELISA and dual stage real time RT-PCR to differentiate Sabin like and non-Sabin like poliovirus isolates.

    Science.gov (United States)

    Kaundal, Nirmal; Sarkate, Purva; Prakash, Charu; Rishi, Narayan

    2017-06-01

    Environmental surveillance of polioviruses has been used as an important tool in monitoring circulation of wild polioviruses and/or Vaccine derived polioviruses in sewage samples. It is important to distinguish Sabin like isolates from non-Sabin like; ELISA & dual stage real time RT-PCR have been used for the same. Current study was carried out on sewage isolates to compare ELISA & RT-PCR with sequencing to distinguish Sabin like from non-Sabin like. Out of 468 sewage specimens, 91 (19.44%) were non-polio enteroviruses positive and 377 (80.56%) were polio positive by virus isolation method. A total of 488 polio virus isolates were detected by L20B and RD route which were further subjected to ELISA and RT-PCR. The results were compared with sequencing. On comparison, the specificity of ELISA was only 66.67% in spite of very low sensitivity (3.43%). The sensitivity of RT-PCR was 97.71% which makes it a good primary screening test for detection of non-Sabin like viruses. However, the specificity was only 33.33%. RT-PCR appears to be a sensitive tool for detecting non-Sabin like viruses however; the isolates which are non-Sabin like by RT-PCR may not necessarily be mutated viruses. ELISA cannot be used for differentiation of Sabin likes from non-Sabin likes due to low sensitivity.

  4. De identificatie van een zilveren microscoopje van Antoni van Leeuwenhoek (1632-1723

    Directory of Open Access Journals (Sweden)

    Tiemen Cocquyt

    2016-05-01

    Full Text Available A hitherto unknown silver microscope of the famous Delft microscopist Antoni van Leeuwenhoek has been identified as genuine, thanks to an intensive investigation using various modern forensic techniques. In this research the preserved Leeuwenhoek microscopes with known provenance were used as a benchmark. It is argued that for a reliable judgement about the authenticity of an object a holistic approach is required: a forensic investigation needs to assess its origin, style characteristics, material properties and production techniques, as well as 'connoisseurship' and the object’s publication history. In this paper all these aspects and their pitfall are discussed. The optical research has shown that the newly discovered instrument has a blown lens (similar to the Utrecht Leeuwenhoek microscope, with a magnification of 248 times, which makes it one of the strongest magnifying Leeuwenhoek microscopes preserved.

  5. The discovery of microorganisms by Robert Hooke and Antoni Van Leeuwenhoek, fellows of the Royal Society.

    Science.gov (United States)

    Gest, Howard

    2004-05-01

    The existence of microscopic organisms was discovered during the period 1665-83 by two Fellows of The Royal Society, Robert Hooke and Antoni van Leeuwenhoek. In Micrographia (1665), Hooke presented the first published depiction of a microganism, the microfungus Mucor. Later, Leeuwenhoek observed and described microscopic protozoa and bacteria. These important revelations were made possible by the ingenuity of Hooke and Leeuwenhoek in fabricating and using simple microscopes that magnified objects from about 25-fold to 250-fold. After a lapse of more than 150 years, microscopy became the backbone of our understanding of the roles of microbes in the causation of infectious diseases and the recycling of chemical elements in the biosphere.

  6. COSANI-2, Gamma Doses from SABINE Calculation, Activity from ANISN Flux Calculation

    International Nuclear Information System (INIS)

    Dupont, C.

    1975-01-01

    1 - Nature of physical problem solved: Retrieval of SABINE and/or ANISN results. Calculates in case of SABINE results the individual contributions of capture gamma rays in each region to the total gamma dose and to the total gamma heating may calculate in case of ANISN new activity rates starting from ANISN flux saved on tape and activity cross sections taken on an ANISN binary library tape. The program can draw on a BENSON plotter any of the following quantities: - group flux; - activity rates; - dose rates; - neutron spectra for SABINE; - neutron or gamma direct or adjoint spectra for ANISN; - gamma heating and dose rate for SABINE including individual contributions from each region. Several ANISN and/or SABINE cases can be drawn on the same graph for comparison purposes. 2 - Restrictions on the complexity of the problem: Maximum number of: - tapes containing ANISN and/or SABINE results: 5; - curves per graph: 3; - regions: 40; - points per curve: 500; - energy groups: 200

  7. Antoni Quintana-Marí (1907-1998): A Pioneer of the Use of History of Science in Science Education

    Science.gov (United States)

    Roca-Rosell, Antoni; Grapí-Vilumara, Pere

    2010-09-01

    In the early 1930s, the young Antoni Quintana-Marí undertook some research on Antoni de Martí i Franquès, one of the most prominent Catalan scientists of the Enlightenment. This scientist worked in Tarragona, where Quintana-Marí lived. Quintana-Marí learnt about Martí i Franquès from Josep Estalella, his teacher of physics and chemistry at the secondary school. It was while researching on Martí i Franquès that Quintana-Marí became a true historian of science. He subsequently collaborated with other Spanish and foreign historians of science in the early years of this discipline. Quintana-Marí never forgot that his passion for history of science had been aroused by his school teacher.

  8. Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria

    OpenAIRE

    Famulare, Michael; Chang, Stewart; Iber, Jane; Zhao, Kun; Adeniji, Johnson A.; Bukbuk, David; Baba, Marycelin; Behrend, Matthew; Burns, Cara C.; Oberste, M. Steven

    2015-01-01

    To assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studied molecular evolution in Sabin-like poliovirus isolates from Nigerian acute flaccid paralysis cases obtained from routine surveillance. We employed a novel modeling approach to infer substitution and recombination rates from whole-genome sequences and information about poliovirus infection dynamics and the individual vaccination history. We confirmed observations from a recent vaccine trial that VP1 sub...

  9. [Immunogenicity of sabin inactivated poliovirus vaccine induced by diphtheria-tetanus-acellular pertussis and Sabin inactivated poliovirus combined vaccine].

    Science.gov (United States)

    Ma, Yan; Qin, Min; Hu, Hui-Qiong; Ji, Guang; Feng, Ling; Gao, Na; Gu, Jie; Xie, Bing-Feng; He, Ji-Hong; Sun, Ming-Bo

    2011-06-01

    In order to search the preparation process and optimazing dosage ratio of adsorbed diphtheria-tetanus-acellular pertussis and sabin inactivated poliovirus combined vaccine (DTaP-sIPV), the neutralizing antibody titers of IPV induced by different concentration of DTaP-sIPV were investigated on rats. Two batches of DTaP-sLPV were produced using different concentration of sIPV and the quality control was carried. Together with sabin-IPV and DTaP-wIPV ( boostrix-polio, GSK, Belgium) as control group, the DTaP-sIPV were administrated on three-dose schedule at 0, 1, 2 month on rats. Serum sample were collected 30 days after each dose and neutralizing antibody titers against three types poliovirus were determined using micro-neutralization test. Two batches of prepared DTaP-sIPV and control sLPV were according to the requirement of Chinese Pharmacopoeia (Volume III, 2005 edition) and showed good stability. The seropositivity rates were 100% for sabin inactivated poliovirus antigen in all groups. The GMTs (Geometric mean titers) of neutralizing antibodies against three types poliovirus increased. The prepared DTaP-sIPV was safe, stable and effective and could induced high level neutralizing antibody against poliovirus on rats.

  10. Albert Sabin and the Coalition to Eliminate Polio from the Americas.

    Science.gov (United States)

    Hampton, Lee

    2009-01-01

    Albert B. Sabin, MD, developer of the oral polio vaccine, was also a major proponent of its use in annual vaccination campaigns aimed at the elimination of polio. Sabin argued that administering his vaccine simultaneously to every child in a country would break polio's chains of transmission. Although he was already promoting mass vaccination by the 1960s, Sabin's efforts expanded considerably when he became an adviser to groups fighting polio in the Americas in the 1980s. Sabin's experiences provide a window into both the formation of the coalition that eliminated poliomyelitis from the Western Hemisphere and what can happen when biomedical researchers become public health policy advisers. Although the polio elimination coalition succeeded in part because member groups often accommodated each other's priorities, Sabin was often limited by his indifference to the interests of those he was advising and to the shortcomings of his vaccine.

  11. [Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety].

    Science.gov (United States)

    Bian, Chuan-xiu; Jiang, Shu-de; Yang, Jian-yong; Sun, Ming-bo; Xie, Ming-xue; Zhang, Xin-wen; Liao, Guo-yang; Li, Wei-dong

    2007-03-01

    To investigate the effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine (IPV). Sabin IPV samples containing 5 mg or 7 mg 2-phenoxyethanol each dosage respectively were placed separately at 4 degrees C, 37 degrees C for 2 days and 7 days. D-antigen contents were tested with ELISA method. Then neutralizing antibodies in mice and guinea pigs were detected. The safety experiment was performed according to unusual toxicity test of China requirement for biological product. After addition of 2-phenoxyethanol, the I, II, and III D-antigen contents of Sabin IPV did not change. The antibody levels in mice and guinea pigs were not different between experimental group and control group. Animals were safe during observation period. 2-Phenoxyethanol had no effect on potency and safety of Sabin IPV. It can be used as antiseptic for Sabin IPV.

  12. Decay of Sabin inactivated poliovirus vaccine (IPV)-boosted poliovirus antibodies

    OpenAIRE

    Resik, Sonia; Tejeda, Alina; Fonseca, Magile; Sein, Carolyn; Hung, Lai Heng; Martinez, Yenisleidys; Diaz, Manuel; Okayasu, Hiromasa; Sutter, Roland W.

    2015-01-01

    Introduction: We conducted a follow-on study to a phase I randomized, controlled trial conducted in Cuba, 2012, to assess the persistence of poliovirus antibodies at 21–22 months following booster dose of Sabin-IPV compared to Salk-IPV in adults who had received multiple doses of oral poliovirus vaccine (OPV) during childhood. Methods: In 2012, 60 healthy adult males aged 19–23 were randomized to receive one booster dose, of either Sabin-inactivated poliovirus vaccine (Sabin-IPV), adjuvant...

  13. Molecular Mechanisms of Attenuation of the Sabin Strain of Poliovirus Type 3

    OpenAIRE

    Guest, Stephen; Pilipenko, Evgeny; Sharma, Kamal; Chumakov, Konstantin; Roos, Raymond P.

    2004-01-01

    Mutations critical for the central nervous system (CNS) attenuation of the Sabin vaccine strains of poliovirus (PV) are located within the viral internal ribosome entry site (IRES). We examined the interaction of the IRESs of PV type 3 (PV3) and Sabin type 3 (Sabin3) with polypyrimidine tract-binding protein (PTB) and a neural cell-specific homologue, nPTB. PTB and nPTB were found to bind to a site directly adjacent to the attenuating mutation, and binding at this site was less efficient on t...

  14. Pioneering figures in medicine: Albert Bruce Sabin--inventor of the oral polio vaccine.

    Science.gov (United States)

    Smith, Derek R; Leggat, Peter A

    2005-01-01

    Over ten years after his death, the Sabin oral vaccine continues its profound influence on public health throughout the world. The annual incidence of polio has fallen dramatically since its introduction, with more than 300,000 lives being spared each year and an annual global saving in excess of 1 billion US dollars. In many ways, the development of an effective oral vaccine and its subsequent regulation by the World Health Organization can serve as a model for medical researchers. Our review describes the contribution of Albert Sabin as a medical researcher, and how his vaccine had a profound impact on the global reduction of polio infections. As many different factors influenced health-care last century, we describe Sabin's involvement with respect to prevailing scientific paradigms and public health issues of the time. Our paper also outlines the basic epidemiology of poliovirus and the historical development of an effective vaccine, both with and without Albert Sabin.

  15. Converting Sabine absorption coefficients to random incidence absorption coefficients

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho

    2013-01-01

    are suggested: An optimization method for the surface impedances for locally reacting absorbers, the flow resistivity for extendedly reacting absorbers, and the flow resistance for fabrics. With four porous type absorbers, the conversion methods are validated. For absorbers backed by a rigid wall, the surface...... coefficients to random incidence absorption coefficients are proposed. The overestimations of the Sabine absorption coefficient are investigated theoretically based on Miki's model for porous absorbers backed by a rigid wall or an air cavity, resulting in conversion factors. Additionally, three optimizations...... impedance optimization produces the best results, while the flow resistivity optimization also yields reasonable results. The flow resistivity and flow resistance optimization for extendedly reacting absorbers are also found to be successful. However, the theoretical conversion factors based on Miki's model...

  16. Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine.

    OpenAIRE

    Bouchard, M J; Lam, D H; Racaniello, V R

    1995-01-01

    To identify determinants of attenuation in the poliovirus type 1 Sabin vaccine strain, a series of recombinant viruses were constructed by using infectious cDNA clones of the virulent type 1 poliovirus P1/Mahoney and the attenuated type 1 vaccine strain P1/Sabin. Intracerebral inoculation of these viruses into transgenic mice which express the human receptor for poliovirus identified regions of the genome that conferred reduced neurovirulence. Exchange of smaller restriction fragments and sit...

  17. Sit Down with Sabin: Venkat Srinivasan: The Future of Batteries (LBNL Summer Lecture Series)

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Sabin; Srinivasan, Venkat

    2011-06-29

    Lawrence Berkeley National Laboratory battery scientist Venkat Srinivasan appears June 29, 2011 on "Sit Down with Sabin," a weekly conversation in which former reporter Sabin Russell chats with Berkeley Lab staff about innovative science. Over the course of several conversations held at noon in the Building 50 auditorium, Russell and Lab staff will explore the ups and downs of pioneering science — all without the aid of PowerPoints. Brought to you by Berkeley Lab Public Affairs.

  18. Does diet in lacertid lizards reflect prey availability? Evidence for selective predation in the Aeolian wall lizard, Podarcis raffonei (Mertens, 1952 (Reptilia, Lacertidae

    Directory of Open Access Journals (Sweden)

    Pietro Lo Cascio

    2011-06-01

    Full Text Available In this paper the invertebrate fauna occurring on Scoglio Faraglione, a tiny Aeolian island (AeolianArchipelago, NE Sicily inhabited by a population of the critically endangered lacertid lizard Podarcis raffonei(Mertens, 1952, was censused at different seasons and the resulting data were then compared with dataobtained analysing prey composition and prey abundance in the diet of the lizards occurring on the same islet.The diet of Podarcis raffonei was mainly based on insects and other arthropods. The results indicate that dietcomposition is not directly influenced by prey availability and temporal prey abundance, and that there isstrong evidence indicating selective predation. Lizards prey upon a number of arthropod categories fewer thanthat recorded in field. Some invertebrate taxa (e.g. Diptera and Gastropoda are really less attractive for lizardsand are rarely preyed or not preyed at all despite their spatial and/or temporal abundance. This suggests thatPodarcis raffonei is able to operate a hierarchical choice within the range of prey items constituting its preyspectrum, probably through the ability to discriminate between prey chemicals or visually oriented predation.

  19. Phase 3 Trial of a Sabin Strain-Based Inactivated Poliovirus Vaccine.

    Science.gov (United States)

    Liao, Guoyang; Li, Rongcheng; Li, Changgui; Sun, Mingbo; Jiang, Shude; Li, Yanping; Mo, Zhaojun; Xia, Jielai; Xie, Zhongping; Che, Yanchun; Yang, Jingsi; Yin, Zhifang; Wang, Jianfeng; Chu, Jiayou; Cai, Wei; Zhou, Jian; Wang, Junzhi; Li, Qihan

    2016-12-01

     The development of a Sabin strain-based inactivated poliovirus vaccine (Sabin-IPV) is imperative to protecting against vaccine-associated paralytic poliomyelitis in developing countries.  In this double-blinded, parallel-group, noninferiority trial, eligible infants aged 60-90 days were randomly assigned in a ratio of 1:1 to receive either 3 doses of Sabin-IPV or Salk strain-based IPV (Salk-IPV) at 30-day intervals and a booster at the age of 18 months. Immunogenicity and safety were assessed on the basis of a protocol.  Of 1438 infants, 1200 eligible infants were recruited and received either Sabin-IPV or Salk-IPV. From the Sabin-IPV and Salk-IPV groups, 570 and 564 infants, respectively, completed the primary immunization and formed the per-protocol population. The seroconversion rates of the participants who received Sabin-IPV were 100%, 94.9%, and 99.0% (types I, II, and III, respectively), and those of the participants who received Salk-IPV were 94.7%, 91.3%, and 97.9% 1 month after the completion of primary immunization. An anamnestic response for poliovirus types I, II, and III was elicited by a booster in both groups. Except in the case of fever, other adverse events were similar between the 2 groups.  The immune response induced by Sabin-IPV was not inferior to that established with Salk-IPV. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  20. Decay of Sabin inactivated poliovirus vaccine (IPV)-boosted poliovirus antibodies.

    Science.gov (United States)

    Resik, Sonia; Tejeda, Alina; Fonseca, Magile; Sein, Carolyn; Hung, Lai Heng; Martinez, Yenisleidys; Diaz, Manuel; Okayasu, Hiromasa; Sutter, Roland W

    We conducted a follow-on study to a phase I randomized, controlled trial conducted in Cuba, 2012, to assess the persistence of poliovirus antibodies at 21-22 months following booster dose of Sabin-IPV compared to Salk-IPV in adults who had received multiple doses of oral poliovirus vaccine (OPV) during childhood. In 2012, 60 healthy adult males aged 19-23 were randomized to receive one booster dose, of either Sabin-inactivated poliovirus vaccine (Sabin-IPV), adjuvanted Sabin-IPV (aSabin-IPV), or conventional Salk-IPV. In the original study, blood was collected at days 0 (before) and 28 (after vaccination), respectively. In this study, an additional blood sample was collected 21-22 months after vaccination, and tested for neutralizing antibodies to Sabin poliovirus types 1, 2 and 3. We collected sera from 59/60 (98.3%) subjects; 59/59 (100%) remained seropositive to all poliovirus types, 21-22 months after vaccination. The decay curves were very similar among the study groups. Between day 28 and 21-22 months, there was a reduction of ⩾87.4% in median antibody levels for all poliovirus types in all study groups, with no significant differences between the study groups. The decay of poliovirus antibodies over a 21-22-month period was similar regardless of the type of booster vaccine used, suggesting the scientific data of Salk IPV long-term persistence and decay may be broadly applicable to Sabin IPV.

  1. Inactivated polio vaccine development for technology transfer using attenuated Sabin poliovirus strains to shift from Salk-IPV to Sabin-IPV.

    Science.gov (United States)

    Bakker, Wilfried A M; Thomassen, Yvonne E; van't Oever, Aart G; Westdijk, Janny; van Oijen, Monique G C T; Sundermann, Lars C; van't Veld, Peter; Sleeman, Eelco; van Nimwegen, Fred W; Hamidi, Ahd; Kersten, Gideon F A; van den Heuvel, Nico; Hendriks, Jan T; van der Pol, Leo A

    2011-09-22

    Industrial-scale inactivated polio vaccine (IPV) production dates back to the 1960s when at the Rijks Instituut voor de Volksgezondheid (RIV) in Bilthoven a process was developed based on micro-carrier technology and primary monkey kidney cells. This technology was freely shared with several pharmaceutical companies and institutes worldwide. In this contribution, the history of one of the first cell-culture based large-scale biological production processes is summarized. Also, recent developments and the anticipated upcoming shift from regular IPV to Sabin-IPV are presented. Responding to a call by the World Health Organization (WHO) for new polio vaccines, the development of Sabin-IPV was continued, after demonstrating proof of principle in the 1990s, at the Netherlands Vaccine Institute (NVI). Development of Sabin-IPV plays an important role in the WHO polio eradication strategy as biocontainment will be critical in the post-OPV cessation period. The use of attenuated Sabin strains instead of wild-type Salk polio strains will provide additional safety during vaccine production. Initially, the Sabin-IPV production process will be based on the scale-down model of the current, and well-established, Salk-IPV process. In parallel to clinical trial material production, process development, optimization and formulation research is being carried out to further optimize the process and reduce cost per dose. Also, results will be shown from large-scale (to prepare for future technology transfer) generation of Master- and Working virus seedlots, and clinical trial material (for phase I studies) production. Finally, the planned technology transfer to vaccine manufacturers in low and middle-income countries is discussed. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase.

    Science.gov (United States)

    Liu, Xinran; Musser, Derek M; Lee, Cheri A; Yang, Xiaorong; Arnold, Jamie J; Cameron, Craig E; Boehr, David D

    2015-10-26

    The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I) in the RNA-dependent RNA polymerase (RdRp). We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are attenuated in a mouse model of poliovirus. Given these results, it was surprising that the nucleotide incorporation rate and nucleobase fidelity of the Sabin I RdRp is similar to that of wild-type enzyme, although the Sabin I RdRp is less selective against nucleotides with modified sugar groups. We suggest that the other Sabin amino acid changes (i.e., D53N, Y73H, K250E) help to re-establish nucleotide incorporation rates and nucleotide discrimination near wild-type levels, which may be a requirement for the propagation of the virus and its efficacy as a vaccine strain. These results also suggest that the nucleobase fidelity of the Sabin I RdRp likely does not contribute to viral attenuation.

  3. Nucleobase but not Sugar Fidelity is Maintained in the Sabin I RNA-Dependent RNA Polymerase

    Directory of Open Access Journals (Sweden)

    Xinran Liu

    2015-10-01

    Full Text Available The Sabin I poliovirus live, attenuated vaccine strain encodes for four amino acid changes (i.e., D53N, Y73H, K250E, and T362I in the RNA-dependent RNA polymerase (RdRp. We have previously shown that the T362I substitution leads to a lower fidelity RdRp, and viruses encoding this variant are attenuated in a mouse model of poliovirus. Given these results, it was surprising that the nucleotide incorporation rate and nucleobase fidelity of the Sabin I RdRp is similar to that of wild-type enzyme, although the Sabin I RdRp is less selective against nucleotides with modified sugar groups. We suggest that the other Sabin amino acid changes (i.e., D53N, Y73H, K250E help to re-establish nucleotide incorporation rates and nucleotide discrimination near wild-type levels, which may be a requirement for the propagation of the virus and its efficacy as a vaccine strain. These results also suggest that the nucleobase fidelity of the Sabin I RdRp likely does not contribute to viral attenuation.

  4. Antigenic characterization of a formalin-inactivated poliovirus vaccine derived from live-attenuated Sabin strains.

    Science.gov (United States)

    Tano, Yoshio; Shimizu, Hiroyuki; Martin, Javier; Nishimura, Yorihiro; Simizu, Bunsiti; Miyamura, Tatsuo

    2007-10-10

    A candidate inactivated poliovirus vaccine derived from live-attenuated Sabin strains (sIPV), which are used in the oral poliovirus vaccine (OPV), was prepared in a large-production scale. The modification of viral antigenic epitopes during the formalin inactivation process was investigated by capture ELISA assays using type-specific and antigenic site-specific monoclonal antibodies (MoAbs). The major antigenic site 1 was modified during the formalin inactivation of Sabin 1. Antigenic sites 1-3 were slightly modified during the formalin inactivation of Sabin 2 strain. Sites 1 and 3 were altered on inactivated Sabin 3 virus. These alterations were different to those shown by wild-type Saukett strain, used in conventional IPV (cIPV). It has been previously reported that type 1 sIPV showed higher immunogenicity to type 1 cIPV whereas types 2 and 3 sIPV induced lower level of immunogenicity than their cIPV counterparts. Our results suggest that the differences in epitope structure after formalin inactivation may account, at least in part, for the observed differences in immunogenicity between Sabin and wild-type inactivated poliovaccines.

  5. Reactogenicity and immunogenicity of inactivated poliovirus vaccine produced from Sabin strains: a phase I Trial in healthy adults in Cuba.

    Science.gov (United States)

    Resik, Sonia; Tejeda, Alina; Fonseca, Magilé; Alemañi, Nilda; Diaz, Manuel; Martinez, Yenisleidys; Garcia, Gloria; Okayasu, Hiromasa; Burton, Anthony; Bakker, Wilfried A M; Verdijk, Pauline; Sutter, Roland W

    2014-09-22

    To ensure that developing countries have the option to produce inactivated poliovirus vaccine (IPV), the Global Polio Eradication Initiative has promoted the development of an IPV using Sabin poliovirus strains (Sabin IPV). This trial assessed the reactogenicity and immunogenicity of Sabin IPV and adjuvanted Sabin IPV in healthy adults in Cuba. This is a randomized, controlled phase I trial, enrolling 60 healthy (previously vaccinated) male human volunteers, aged 19-23 years to receive one dose of either Sabin IPV (20:32:64 DU/dose), adjuvanted Sabin IPV (10:16:32 DU/dose), or conventional Salk IPV (40:8:32 DU/dose). The primary endpoint for reactogenicity relied on monitoring of adverse events. The secondary endpoint measured boosting immune responses (i.e. seroconversion or 4-fold rise) of poliovirus antibody, assessed by neutralization assays. Sixty subjects fulfilled the study requirements. No serious adverse events reported were attributed to trial interventions during the 6-month follow-up period. Twenty-eight days after vaccination, boosting immune responses against poliovirus types 1-3 were between 90% and 100% in all vaccination groups. There was a more than 6-fold increase in median antibody titers between pre- and post-vaccination titers in all vaccination groups. Both Sabin IPV and adjuvanted Sabin IPV were well tolerated and immunogenic against all poliovirus serotypes. This result suggests that the aluminum adjuvant may allow a 50% (or higher) dose reduction. Copyright © 2014. Published by Elsevier Ltd.

  6. Characterization and standardization of Sabin based inactivated polio vaccine: proposal for a new antigen unit for inactivated polio vaccines.

    Science.gov (United States)

    Westdijk, Janny; Brugmans, Debbie; Martin, Javier; van't Oever, Aart; Bakker, Wilfried A M; Levels, Lonneke; Kersten, Gideon

    2011-04-18

    GMP-batches of Sabin-IPV were characterized for their antigenic and immunogenic properties. Antigenic fingerprints of Sabin-IPV reveal that the D-antigen unit is not a fixed amount of antigen but depends on antibody and assay type. Instead of the D-antigen unit we propose standardization of IPV based on a combination of protein amount for dose and D-antigenicity for quality of the vaccine. Although Sabin-IPV type 2 is less immunogenic than regular wild type IPV type 2, the immunogenicity (virus neutralizing titers) per microgram antigen for Sabin-IPV type 2 is in the same order as for wild type serotypes 1 and 3. The latter observations are in line with data from human trials. This suggests that a higher dose of Sabin-IPV type 2 to compensate for the lower rat immunogenicity may not be necessary. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. [The effect of aluminum adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine].

    Science.gov (United States)

    Wang, Fang; Zhang, Ming; Xie, Bing-Feng; Cao, Han; Tong, Shao-Yong; Wang, Jun-Rong; Yu, Xiao-Ping; Tang, Yang; Yang, Jing-Ran; Sun, Ming-Bo

    2013-04-01

    To study the effect of aluminume adjuvant and immunization schedule on immunogenicity of Sabin inactivated poliovirus vaccine. Four batches of Sabin IPV were produced by different concentrations of type 1, 2, and 3 poliovirus and administrated on three-dose schedule at 0, 1, 2 months and 0, 2, 4 months on rats. Serum samples were collected one month after each dose and neutralizing antibody titers against three types poliovirus were determined by micro-neutralization assay. The GMTs of neutralizing antibodies against three types poliovirus increased significantly and the seropositivity rates were 100% in all groups after 3 doses. There was no significant difference between two immunization schedules, and the 0, 2, 4 month schedule could induce higher level neutralizing antibody compared to the 0, 1, 2 month schedule. The groups with aluminum adjuvant could induce higher level neutralizing antibody compared to the groups without adjuvant. Aluminum djuvant and immunization schedule could improve the immunogenicity of Sabin IPV.

  8. Clinical development of a novel inactivated poliomyelitis vaccine based on attenuated Sabin poliovirus strains.

    Science.gov (United States)

    Verdijk, Pauline; Rots, Nynke Y; Bakker, Wilfried A M

    2011-05-01

    Following achievement of polio eradication, the routine use of all live-attenuated oral poliovirus vaccines should be discontinued. However, the costs per vaccine dose for the alternative inactivated poliovirus vaccine (IPV) are significantly higher and the current production capacity is not sufficient for worldwide distribution of the vaccine. In order to achieve cost-prize reduction and improve affordability, IPV production processes and dose-sparing strategies should be developed to facilitate local manufacture at a relatively lower cost. The use of attenuated Sabin instead of wild-type polio strains will provide additional safety during vaccine production and permits production in low-cost settings. Sabin-IPV is under development by several manufacturers. This article gives an overview of results from clinical trials with Sabin-IPV and discusses the requirements and challenges in the clinical development of this novel IPV.

  9. Her Excellency Mrs Sarah Gillett Her Majesty's Ambassador to the Swiss Confederation United Kingdom of Great Britain and Northern Ireland on the occasion of the Antony Gormley sculpture unveiling ceremony Wednesday 7th December 2011

    CERN Document Server

    Maximilien Brice

    2011-01-01

    Her Excellency Mrs Sarah Gillett Her Majesty's Ambassador to the Swiss Confederation United Kingdom of Great Britain and Northern Ireland on the occasion of the Antony Gormley sculpture unveiling ceremony Wednesday 7th December 2011

  10. Hypersensitivity reactions to the Sabin vaccine in children with cow's milk allergy.

    Science.gov (United States)

    Parisi, C A S; Smaldini, P L; Gervasoni, M E; Maspero, J F; Docena, G H

    2013-02-01

    The Sabin vaccine is used world-wide, and most children with food allergies receive it without incident. However, in the 2009 vaccination campaign conducted in Argentina, four children experienced immediate-type hypersensitivity reactions following vaccination. We aimed to review the medical history of the affected children, study their allergic condition after the episodes and analyse the presence of allergenic vaccine components. Patients were selected based on their immediate allergic reactions following vaccination. They were assessed for allergies to cow's milk and hen's egg. The presence of cow's milk proteins in the vaccine was tested by various immunoassays involving cow's milk- or α-lactalbumin-specific polyclonal rabbit antiserum and patient sera. All of the patients had a history of milk allergy, and no history or current evidence of egg hypersensitivity was found. Levels of cow's milk- and Sabin vaccine-specific IgE were increased, and the result of a skin prick test with cow's milk proteins or the Sabin vaccine was positive in each patient. In addition, an ELISA using specific rabbit antiserum detected α-lactalbumin in the Sabin vaccine. When α-lactalbumin was employed as a soluble inhibitor in a competitive ELISA, binding to vaccine-coated plates by cow's milk- or α-lactalbumin-specific rabbit antiserum or by patient serum containing IgE was inhibited. We have demonstrated that these patients were allergic to cow's milk, and had circulating and mast cell-bound IgE antibodies specific to cow's milk proteins. We found that the Sabin vaccine contained α-lactalbumin, which may have been responsible for the reactions elicited following vaccination with the Sabin and dual viral vaccines in combination. © 2012 Blackwell Publishing Ltd.

  11. A Cluster of Paralytic Poliomyelitis Cases Due to Transmission of Slightly Diverged Sabin 2 Vaccine Poliovirus.

    Science.gov (United States)

    Korotkova, Ekaterina A; Gmyl, Anatoly P; Yakovenko, Maria L; Ivanova, Olga E; Eremeeva, Tatyana P; Kozlovskaya, Liubov I; Shakaryan, Armen K; Lipskaya, Galina Y; Parshina, Irina L; Loginovskikh, Nataliya V; Morozova, Nadezhda S; Agol, Vadim I

    2016-07-01

    Four cases of acute flaccid paralysis caused by slightly evolved (Sabin-like) vaccine polioviruses of serotype 2 were registered in July to August 2010 in an orphanage of Biysk (Altai Region, Russia). The Biysk cluster of vaccine-associated paralytic poliomyelitis (VAPP) had several uncommon, if not unique, features. (i) Until this outbreak, Sabin-like viruses (in distinction to more markedly evolved vaccine-derived polioviruses [VDPVs]) were reported to cause only sporadic cases of VAPP. Consequently, VAPP cases were not considered to require outbreak-type responses. However, the Biysk outbreak completely blurred the borderline between Sabin-like viruses and VDPVs in epidemiological terms. (ii) The outbreak demonstrated a very high disease/infection ratio, apparently exceeding even that reported for wild polioviruses. The viral genome structures did not provide any substantial hints as to the underlying reason(s) for such pathogenicity. (iii) The replacement of intestinal poliovirus lineages by other Sabin-like lineages during short intervals after the disease onsets was observed in two patients. Again, the sequences of the respective genomes provided no clues to explain these events. (iv) The polioviruses isolated from the patients and their contacts demonstrated a striking heterogeneity as well as rapid and uneven evolution of the whole genomes and their parts, apparently due to extensive interpersonal contacts in a relatively small closed community, multiple bottlenecking, and recombination. Altogether, the results demonstrate several new aspects of pathogenicity, epidemiology, and evolution of vaccine-related polioviruses and underscore several serious gaps in understanding these problems. The oral poliovirus vaccine largely contributed to the nearly complete disappearance of poliovirus-caused poliomyelitis. Being generally safe, it can, in some cases, result in a paralytic disease. Two types of such outcomes are distinguished: those caused by slightly

  12. Bayesian inversion from sabine absorption coefficients to flow resistivity values for porous absorbers

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho

    2015-01-01

    to determine the flow resistivity of a porous material from the Sabine absorption coefficient was investigated through a reliable model. The model for the flow resistivity estimation is based on an equivalent fluid model, i.e., Miki’s model, together with the most advanced model that accounts for edge...... diffraction, named Thomasson’s finite size correction. As input data, a set of the Sabine absorption coefficients in a recent absorption round robin test in 13 European chambers was used. Finally, the flow resistivity of the test specimen is characterized via the Bayesian framework, together...

  13. „Der“ Feminismus – „die“ Wissenschaft. Sabine Hark stellt metafeministische Fragen Feminism-Science: Sabine Hark Poses Meta-Feminist Questions

    Directory of Open Access Journals (Sweden)

    Petra Gehring

    2006-07-01

    Full Text Available Ein Anlauf zu einem großen Thema: Wie veränderte sich der Feminismus im Zuge des „akademisch Werdens“ der feministischen Theorie? Sabine Hark mischt Theoriekritik mit Wissens- und Universitätssoziologie. Heraus kommen im Ergebnis allerdings eher vorsichtige, ambivalente Einschätzungen – aus einer Perspektive von irgendwo oberhalb des feministischen Diskurses, einem schwer bestimmbaren Ort. Immerhin: Kapitel 5 enthält eine handfeste und wichtige These.A preliminary approach to a considerable theme: How does feminism change in relation to the “academic development” of feminist theory? Sabine Hark mixes critique of theory with sociology of knowledge and university sociology. Her results are ultimately rather careful, ambivalent assessments occurring from a perspective somewhere above feminist discourse, which is a very difficult place to pinpoint. Chapter five does contain a sound and important thesis.

  14. Studies on Lyophilization of Sabin Vaccine. 2. Investigation on Long Time Incubation at High and Low Temperatures of Lyophilized Sabin Vaccine

    OpenAIRE

    塩見, 洋; 浦沢, 价子; 浦沢, 正三

    1998-01-01

    Lyophilization of vaccine is one of the possible options for the development of a heat-stable poliovaccine. In our previous study in which conditions affecting the lyophilization of Sabin poliovaccine were investigated, it was found that infectivity titration of lyophilized viruses was under at least three kind of variabilities i. e., i) the variability among different lyophilization experi-ments, ii) the variability within the same lyophilization experiment and iii) the variability inherent ...

  15. Decay of Sabin inactivated poliovirus vaccine (IPV-boosted poliovirus antibodies

    Directory of Open Access Journals (Sweden)

    Sonia Resik

    2015-01-01

    Conclusion: The decay of poliovirus antibodies over a 21–22-month period was similar regardless of the type of booster vaccine used, suggesting the scientific data of Salk IPV long-term persistence and decay may be broadly applicable to Sabin IPV.

  16. 78 FR 55214 - Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX

    Science.gov (United States)

    2013-09-10

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2013-0723] Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX AGENCY: Coast Guard, DHS... Neches River in Orange, TX from 3 p.m. on September 20, 2013, through 6 p.m. on September 22, 2013. This...

  17. 77 FR 47519 - Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX

    Science.gov (United States)

    2012-08-09

    ... DEPARTMENT OF HOMELAND SECURITY Coast Guard 33 CFR Part 100 [Docket No. USCG-2012-0656] Annual Marine Events in the Eighth Coast Guard District, Sabine River; Orange, TX AGENCY: Coast Guard, DHS... Regulations for the S.P.O.R.T. Power Boat Neches River in Orange, TX from 3 p.m. on September 21, 2012...

  18. Reproducibility of The Random Incidence Absorption Coefficient Converted From the Sabine Absorption Coefficient

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho; Chang, Ji-ho

    2015-01-01

    largely depending on the test room. Several conversion methods for porous absorbers from the Sabine absorption coefficient to the random incidence absorption coefficient were suggested by considering the finite size of a test specimen and non-uniformly incident energy onto the specimen, which turned out...... resistivity optimization outperforms the surface impedance optimization in terms of the reproducibility....

  19. 75 FR 62512 - Sabine Pass Liquefaction, LLC; Application for Long-Term Authorization To Export Liquefied...

    Science.gov (United States)

    2010-10-12

    ... than two years) with third parties with terms up to 30 years executed by September 7, 2020. The LNG may... Application, as countries that hold membership in the World Trade Organization (WTO Countries) and those... through job creation, increased economic activity and tax revenues. Second, Sabine Pass maintains that the...

  20. Temporal association between the isolation of Sabin-related poliovirus vaccine strains and the Guillain-Barré syndrome

    OpenAIRE

    Friedrich, F.; Filippis, A. M. B.; Schatzmayr, H. G.

    1996-01-01

    Thirty eight paralysis cases classified as Guillain-Barré syndrome (GBS) in Brazil were analysed. In all these cases Sabin-related poliovirus vaccine strains were isolated. In most of the cases the last vaccine dose was given months or years before the onset of GBS, suggesting a persistent infection or the transmission of the Sabin-related strains to the patients. The isolation of Sabin-related strains from GBS cases some days or weeks after the onset of the disease, demonstrated a temporal a...

  1. Isolation of sabin-like polioviruses from wastewater in a country using inactivated polio vaccine.

    Science.gov (United States)

    Zurbriggen, Sebastian; Tobler, Kurt; Abril, Carlos; Diedrich, Sabine; Ackermann, Mathias; Pallansch, Mark A; Metzler, Alfred

    2008-09-01

    From 2001 to 2004, Switzerland switched from routine vaccination with oral polio vaccine (OPV) to inactivated polio vaccine (IPV), using both vaccines in the intervening period. Since IPV is less effective at inducing mucosal immunity than OPV, this change might allow imported poliovirus to circulate undetected more easily in an increasingly IPV-immunized population. Environmental monitoring is a recognized tool for identifying polioviruses in a community. To look for evidence of poliovirus circulation following cessation of OPV use, two sewage treatment plants located in the Zurich area were sampled from 2004 to 2006. Following virus isolation using either RD or L20B cells, enteroviruses and polioviruses were identified by reverse transcription-PCR. A total of 20 out of 174 wastewater samples were positive for 62 Sabin-like isolates. One isolate from each poliovirus-positive sample was analyzed in more detail. Sequencing the complete viral protein 1 (VP1) capsid coding region, as well as intratypic differentiation (ITD), identified 3 Sabin type 1, 13 Sabin type 2, and 4 Sabin type 3 strains. One serotype 1 strain showed a discordant result in the ITD. Three-quarters of the strains showed mutations within the 5' untranslated region and VP1, known to be associated with reversion to virulence. Moreover, three strains showed heterotypic recombination (S2/S1 and S3/S2/S3). The low number of synonymous mutations and the partial temperature sensitivity are not consistent with extended circulation of these Sabin virus strains. Nevertheless, the continuous introduction of polioviruses into the community emphasizes the necessity for uninterrupted child vaccination to maintain high herd immunity.

  2. 14 November 2013 - Director of Indian Institute of Technology Indore P. Mathur with members of the Indian community working at CERN; visiting the LHC tunnel at Point 2, the ALICE experimental area and SM18 with ALICE Collaboration Spokesperson, Istituto Nazionale Fisica Nucleare P. Giubellino and Technology Department, Accelerator Beam Transfer Group Leader V. Mertens

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    14 November 2013 - Director of Indian Institute of Technology Indore P. Mathur with members of the Indian community working at CERN; visiting the LHC tunnel at Point 2, the ALICE experimental area and SM18 with ALICE Collaboration Spokesperson, Istituto Nazionale Fisica Nucleare P. Giubellino and Technology Department, Accelerator Beam Transfer Group Leader V. Mertens

  3. 7 May 2013 - Ambassador of the Federal Republic of Germany to Switzerland and Liechtenstein P. Gottwald and Mrs Gottwald in the ATLAS experimental cavern and LHC tunnel with Collaboration Deputy Spokesperson T. Wengler and German Scientists A. Schopper and V. Mertens.

    CERN Multimedia

    Maximilien Brice

    2013-01-01

    7 May 2013 - Ambassador of the Federal Republic of Germany to Switzerland and Liechtenstein P. Gottwald and Mrs Gottwald in the ATLAS experimental cavern and LHC tunnel with Collaboration Deputy Spokesperson T. Wengler and German Scientists A. Schopper and V. Mertens.

  4. Temporal association between the isolation of Sabin-related poliovirus vaccine strains and the Guillain-Barré syndrome

    Directory of Open Access Journals (Sweden)

    F. Friedrich

    1996-02-01

    Full Text Available Thirty eight paralysis cases classified as Guillain-Barré syndrome (GBS in Brazil were analysed. In all these cases Sabin-related poliovirus vaccine strains were isolated. In most of the cases the last vaccine dose was given months or years before the onset of GBS, suggesting a persistent infection or the transmission of the Sabin-related strains to the patients. The isolation of Sabin-related strains from GBS cases some days or weeks after the onset of the disease, demonstrated a temporal association between the isolation of the strains and the disease. Although the isolates from the GBS cases may not be the etiological agent of the disease, this study strongly indicates that infections caused by Sabin-related vaccine strains can trigger the GBS in certain cases.

  5. Immunity status of adults and children against poliomyelitis virus type 1 strains CHAT and Sabin (LSc-2ab) in Germany.

    Science.gov (United States)

    Eggers, Maren; Terletskaia-Ladwig, Elena; Rabenau, Holger F; Doerr, Hans W; Diedrich, Sabine; Enders, Gisela; Enders, Martin

    2010-12-09

    In October 2007, the working group CEN/TC 216 of the European Committee for standardisation suggested that the Sabin oral poliovirus vaccine type 1 strain (LSc-2ab) presently used for virucidal tests should be replaced by another attenuated vaccine poliovirus type 1 strain, CHAT. Both strains were historically used as oral vaccines, but the Sabin type 1 strain was acknowledged to be more attenuated. In Germany, vaccination against poliomyelitis was introduced in 1962 using the oral polio vaccine (OPV) containing Sabin strain LSc-2ab. The vaccination schedule was changed from OPV to an inactivated polio vaccine (IPV) containing wild polio virus type 1 strain Mahoney in 1998. In the present study, we assessed potential differences in neutralising antibody titres to Sabin and CHAT in persons with a history of either OPV, IPV, or OPV with IPV booster. Neutralisation poliovirus antibodies against CHAT and Sabin 1 were measured in sera of 41 adults vaccinated with OPV. Additionally, sera from 28 children less than 10 years of age and immunised with IPV only were analysed. The neutralisation assay against poliovirus was performed according to WHO guidelines. The neutralisation activity against CHAT in adults with OPV vaccination history was significantly lower than against Sabin poliovirus type 1 strains (Wilcoxon signed-rank test P Sabin 1 varied between 8 and 64. Following IPV booster, anti-CHAT antibodies increased rapidly in sera of CHAT-negative adults with OPV history. Sera from children with IPV history neutralised CHAT and Sabin 1 strains equally. The lack of neutralising antibodies against the CHAT strain in persons vaccinated with OPV might be associated with an increased risk of reinfection with the CHAT polio virus type 1, and this implies a putative risk of transmission of the virus to polio-free communities. We strongly suggest that laboratory workers who were immunised with OPV receive a booster vaccination with IPV before handling CHAT in the laboratory.

  6. Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.

    OpenAIRE

    Equestre, M; Genovese, D; Cavalieri, F; Fiore, L; Santoro, R; Perez Bercoff, R

    1991-01-01

    Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants of poliovirus type 2.

  7. Verification of using SABINE-3.1 code for calculations of radioactive inventory in reactor shield

    International Nuclear Information System (INIS)

    Moukhamadeev, R.; Suvorov, A.

    2000-01-01

    This report presents the results of calculations of radioactive inventory and doses of activation radiation for the International Benchmark Calculations of Radioactive Inventory for Fission Reactor Decommissioning, IAEA, and measurements of activation doses in shield of WWER-440 (Armenian NPP), using one-dimension modified code SABINE-3.1. For decommissioning of NPP it is very important to evaluate in correct manner radioactive inventory in reactor construction and shield materials. One-dimension code SABINE-3.1 (removing-diffusion method for neutron calculation) was modified to perform calculation of radioactive inventory in reactor shield materials and dose from activation photons behind them. These calculations are carried out on the base of nuclear constant system ABBN-78 and new library of activation data for a number of long-lived isotopes, prepared by authors on the base of [9], which present at shield materials as microimpurities and manage radiation situation under the decay more than 1 year. (Authors)

  8. Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells.

    Science.gov (United States)

    Mohanty, Madhu C; Deshpande, Jagadish M

    2013-01-01

    Polioviruses are the causative agent of paralytic poliomyelitis. Attenuated polioviruses (Sabin oral poliovirus vaccine strains) do not replicate efficiently in neurons as compared to the wild type polioviruses and therefore do not cause disease. This study was aimed to investigate the differential host immune response to wild type 1 poliovirus (wild PV) and Sabin attenuated type 1 poliovirus (Sabin PV) in cultured human neuronal cells. By using flow cytometry and real time PCR methods we examined host innate immune responses and compared the role of toll like receptors (TLRs) and cytoplasmic RNA helicases in cultured human neuronal cells (SK-N-SH) infected with Sabin PV and wild PV. Human neuronal cells expressed very low levels of TLRs constitutively. Sabin PV infection induced significantly higher expression of TLR3, TLR7 and melanoma differentiation-associated protein-5 (MDA-5) m-RNA in neuronal cells at the beginning of infection (up to 4 h) as compared to wild PV. Further, Sabin PV also induced the expression of interferon α/β at early time point of infection. The induced expression of IFN α/β gene by Sabin PV in neuronal cells could be suppressed by inhibiting TLR7. Neuronal cell innate immune response to Sabin and wild polioviruses differ significantly for TLR3, TLR7, MDA5 and type 1 interferons. Effects of TLR7 activation and interferon production and Sabin virus replication in neuronal cells need to be actively investigated in future studies.

  9. Differential induction of Toll-like receptors & type 1 interferons by Sabin attenuated & wild type 1 polioviruses in human neuronal cells

    Directory of Open Access Journals (Sweden)

    Madhu C Mohanty

    2013-01-01

    Full Text Available Background & objectives: Polioviruses are the causative agent of paralytic poliomyelitis. Attenuated polioviruses (Sabin oral poliovirus vaccine strains do not replicate efficiently in neurons as compared to the wild type polioviruses and therefore do not cause disease. This study was aimed to investigate the differential host immune response to wild type 1 poliovirus (wild PV and Sabin attenuated type 1 poliovirus (Sabin PV in cultured human neuronal cells. Methods: By using flow cytometry and real time PCR methods we examined host innate immune responses and compared the role of toll like receptors (TLRs and cytoplasmic RNA helicases in cultured human neuronal cells (SK-N-SH infected with Sabin PV and wild PV. Results: Human neuronal cells expressed very low levels of TLRs constitutively. Sabin PV infection induced significantly higher expression of TLR3, TLR7 and melanoma differentiation-associated protein-5 (MDA-5 m-RNA in neuronal cells at the beginning of infection (up to 4 h as compared to wild PV. Further, Sabin PV also induced the expression of interferon α/β at early time point of infection. The induced expression of IFN α/β gene by Sabin PV in neuronal cells could be suppressed by inhibiting TLR7. Interpretation & conclusions: Neuronal cell innate immune response to Sabin and wild polioviruses differ significantly for TLR3, TLR7, MDA5 and type 1 interferons. Effects of TLR7 activation and interferon production and Sabin virus replication in neuronal cells need to be actively investigated in future studies.

  10. The archaeology of computer codes - illustrated on the basis of the code SABINE

    International Nuclear Information System (INIS)

    Sdouz, G.

    1987-02-01

    Computer codes used by the physics group of the Institute for Reactor Safety are stored on back-up-tapes. However during the last years both the computer and the system have been changed. For new tasks these programmes have to be available. A new procedure is necessary to find and to activate a stored programme. This procedure is illustrated on the basis of the code SABINE. (Author)

  11. Development and introduction of inactivated poliovirus vaccines derived from Sabin strains in Japan.

    Science.gov (United States)

    Shimizu, Hiroyuki

    2016-04-07

    During the endgame of global polio eradication, the universal introduction of inactivated poliovirus vaccines is urgently required to reduce the risk of vaccine-associated paralytic poliomyelitis and polio outbreaks due to wild and vaccine-derived polioviruses. In particular, the development of inactivated poliovirus vaccines (IPVs) derived from the attenuated Sabin strains is considered to be a highly favorable option for the production of novel IPV that reduce the risk of facility-acquired transmission of poliovirus to the communities. In Japan, Sabin-derived IPVs (sIPVs) have been developed and introduced for routine immunization in November 2012. They are the first licensed sIPVs in the world. Consequently, trivalent oral poliovirus vaccine was used for polio control in Japan for more than half a century but has now been removed from the list of vaccines licensed for routine immunization. This paper reviews the development, introduction, characterization, and global status of IPV derived from attenuated Sabin strains. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications.

    Science.gov (United States)

    Korotkova, Ekaterina; Laassri, Majid; Zagorodnyaya, Tatiana; Petrovskaya, Svetlana; Rodionova, Elvira; Cherkasova, Elena; Gmyl, Anatoly; Ivanova, Olga E; Eremeeva, Tatyana P; Lipskaya, Galina Y; Agol, Vadim I; Chumakov, Konstantin

    2017-11-22

    Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These "weak" segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also suggest that the genome of wild polioviruses, and, by generalization, of other RNA viruses, may harbor hidden low-fitness segments that can be readily eliminated only by recombination.

  13. Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications

    Directory of Open Access Journals (Sweden)

    Ekaterina Korotkova

    2017-11-01

    Full Text Available Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These “weak” segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also suggest that the genome of wild polioviruses, and, by generalization, of other RNA viruses, may harbor hidden low-fitness segments that can be readily eliminated only by recombination.

  14. Hematopoietic Cancer Cell Lines Can Support Replication of Sabin Poliovirus Type 1

    Science.gov (United States)

    van Eikenhorst, Gerco; de Gruijl, Tanja D.; van der Pol, Leo A.; Bakker, Wilfried A. M.

    2015-01-01

    Viral vaccines can be produced in adherent or in suspension cells. The objective of this work was to screen human suspension cell lines for the capacity to support viral replication. As the first step, it was investigated whether poliovirus can replicate in such cell lines. Sabin poliovirus type 1 was serially passaged on five human cell lines, HL60, K562, KG1, THP-1, and U937. Sabin type 1 was capable of efficiently replicating in three cell lines (K562, KG1, and U937), yielding high viral titers after replication. Expression of CD155, the poliovirus receptor, did not explain susceptibility to replication, since all cell lines expressed CD155. Furthermore, we showed that passaged virus replicated more efficiently than parental virus in KG1 cells, yielding higher virus titers in the supernatant early after infection. Infection of cell lines at an MOI of 0.01 resulted in high viral titers in the supernatant at day 4. Infection of K562 with passaged Sabin type 1 in a bioreactor system yielded high viral titers in the supernatant. Altogether, these data suggest that K562, KG1, and U937 cell lines are useful for propagation of poliovirus. PMID:25815312

  15. Development of inactivated poliovirus vaccine from Sabin strains: A progress report.

    Science.gov (United States)

    Okayasu, Hiromasa; Sein, Carolyn; Hamidi, Ahd; Bakker, Wilfried A M; Sutter, Roland W

    2016-11-01

    The Global Polio Eradication Initiative (GPEI) has seen significant progress since it began in 1988, largely due to the worldwide use of oral poliovirus vaccine (OPV). In order to achieve polio eradication the global cessation of OPV is necessary because OPV contains live attenuated poliovirus, which in rare circumstances could re-gain wild poliovirus (WPV) characteristics with potential to establish transmission. The GPEI endgame strategy for the period 2013-2018 recommends the globally synchronised sequential cessation of the Sabin strains contained in the OPV, starting with type 2 Sabin. The withdrawal of Sabin type 2 took place in April 2016, with the introduction of at least one dose of inactivated poliovirus vaccine (IPV) as a risk mitigation strategy. The introduction of IPV into 126 countries since 2013 has required a rapid scale-up of IPV production by the two manufacturers supplying the global public sector market. This scale-up has been fraught with challenges, resulting in reductions of 40-50% of initial supply commitments. Consequently, 22 countries will not be supplied until 2018, and another 23 countries will experience serious stock-outs. In the last decade repeated calls-for-action were made to the global community to invigorate their vision and investment in developing "new poliovirus vaccines" including the development of IPV from less-virulent strains, such as Sabin-IPV (S-IPV). The conventional Salk-IPV production is limited to high-income industrialized-country manufacturers due to the containment requirements (i.e., high sanitation, low force-of-poliovirus-infection, and high population immunity). The use of Sabin strains in the production of S-IPV carries a lower biosafety risk, and was determined to be suitable for production in developing countries, expanding the manufacturing base and making IPV more affordable and accessible in the long term. Significant progress in the S-IPV has been made since 2006. S-IPV is now licensed as S-IPV in

  16. Immune Serum From Sabin Inactivated Poliovirus Vaccine Immunization Neutralizes Multiple Individual Wild and Vaccine-Derived Polioviruses.

    Science.gov (United States)

    Sun, Mingbo; Li, Changgui; Xu, Wenbo; Liao, Guoyang; Li, Rongcheng; Zhou, Jian; Li, Yanping; Cai, Wei; Yan, Dongmei; Che, Yanchun; Ying, Zhifang; Wang, Jianfeng; Yang, Huijuan; Ma, Yan; Ma, Lei; Ji, Guang; Shi, Li; Jiang, Shude; Li, Qihan

    2017-05-15

    A Sabin strain-based inactivated poliomyelitis vaccine (Sabin-IPV) is the rational option for completely eradicating poliovirus transmission. The neutralizing capacity of Sabin-IPV immune serum to different strains of poliovirus is a key indicator of the clinical protective efficacy of this vaccine. Sera collected from 500 infants enrolled in a randomized, blinded, positive control, phase 2 clinical trial were randomly divided into 5 groups: Groups A, B, and C received high, medium, and low doses, respectively, of Sabin-IPV, while groups D and E received trivalent oral polio vaccine and Salk strain-based IPV, respectively, all on the same schedule. Immune sera were collected after the third dose of primary immunization, and tested in cross-neutralization assays against 19 poliovirus strains of all 3 types. All immune sera from all 5 groups interacted with the 19 poliovirus strains with various titers and in a dose-dependent manner. One type 2 immunodeficiency-associated vaccine-derived poliovirus strain was not recognized by these immune sera. Sabin-IPV vaccine can induce protective antibodies against currently circulating and reference wild poliovirus strains and most vaccine-derived poliovirus strains, with rare exceptions. NCT01056705. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  17. Safety and immunogenicity of inactivated poliovirus vaccine based on Sabin strains with and without aluminum hydroxide: a phase I trial in healthy adults.

    Science.gov (United States)

    Verdijk, Pauline; Rots, Nynke Y; van Oijen, Monique G C T; Oberste, M Steven; Boog, Claire J; Okayasu, Hiromasa; Sutter, Roland W; Bakker, Wilfried A M

    2013-11-12

    An inactivated poliovirus vaccine (IPV) based on attenuated poliovirus strains (Sabin-1, -2 and -3) was developed for technology transfer to manufacturers in low- and middle income countries in the context of the Global Polio Eradication Initiative. Safety and immunogenicity of the Sabin-IPV was evaluated in a double-blind, randomized, controlled, phase I 'proof-of-concept' trial. Healthy male adults received a single intramuscular injection with Sabin-IPV, Sabin-IPV adjuvanted with aluminum hydroxide or conventional IPV. Virus-neutralizing titers against both Sabin and wild poliovirus strains were determined before and 28 days after vaccination. No vaccine-related serious adverse events were observed, and all local and systemic reactions were mild or moderate and transient. In all subjects, an increase in antibody titer for all types of poliovirus (both Sabin and wild strains) was observed 28 days after vaccination. Sabin-IPV and Sabin-IPV adjuvanted with aluminum hydroxide administered as a booster dose were equally immunogenic and safe as conventional IPV. EudraCTnr: 2010-024581-22, NCT01708720. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Sit Down with Sabin: Margaret Torn: The Carbon Cycle Like You've Never Seen It (LBNL Summer Lecture Series)

    Energy Technology Data Exchange (ETDEWEB)

    Russell, Sabin; Torn, Margaret

    2011-07-06

    Lawrence Berkeley National Laboratory soil scientist Margaret Torn appears July 6, 2011 on "Sit Down with Sabin," a weekly conversation in which former reporter Sabin Russell chats with Berkeley Lab staff about innovative science. Torn discusses how she travels the world to learn more about soil's huge role in the global carbon cycle. Brought to you by Berkeley Lab Public Affairs.

  19. Bayesian inference of the flow resistivity of a sound absorber and the room's influence on the Sabine absorption coefficients

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho; Choi, Sang-Hyeon; Lee, Ikjin

    2017-01-01

    A Bayesian analysis is applied to determine the flow resistivity of a porous sample and the influence of the test chamber based on measured Sabine absorption coefficient data. The Sabine absorption coefficient measured in a reverberation chamber according to ISO 354 is influenced by the test...... chamber significantly, whereas the flow resistivity is a rather reproducible material property, from which the absorptive characteristics can be calculated through reliable models. Using Sabine absorption coefficients measured in 13 European reverberation chambers, the maximum a posteriori...... and the uncertainty of the flow resistivity and the test chamber’s influence are estimated. Inclusion of more than one chamber’s absorption data helps the flow resistivity converge towards a reliable value with a standard deviation below 17%...

  20. Gain-loss study along two streams in the upper Sabine River basin, Texas; August-September 1981

    Science.gov (United States)

    Myers, Dennis R.

    1983-01-01

    A gain-loss study was made August-September 1981 along the upper Sabine River from Lake Tawakoni to Farm Road 2517 near Carthage and along Lake Fork Creek from Lake Fork Reservoir to its junction (mouth) with the Sabine River. The hydrologic data collected during the gain-loss study indicated that during periods of low flow on the Sabine River, at least as much water as is released from Lake Tawakoni and from Lake Fork Reservoir will be available downstream at Farm Road 14 near Big Sandy and at Farm Road 2517 near Carthage. Gains from bank seepage and small tributary inflows compensate for losses due to evaporation, evapotranspiration, and loss of water into the alluvial aquifer.

  1. Immunity status of adults and children against poliomyelitis virus type 1 strains CHAT and Sabin (LSc-2ab in Germany

    Directory of Open Access Journals (Sweden)

    Diedrich Sabine

    2010-12-01

    Full Text Available Abstract Background In October 2007, the working group CEN/TC 216 of the European Committee for standardisation suggested that the Sabin oral poliovirus vaccine type 1 strain (LSc-2ab presently used for virucidal tests should be replaced by another attenuated vaccine poliovirus type 1 strain, CHAT. Both strains were historically used as oral vaccines, but the Sabin type 1 strain was acknowledged to be more attenuated. In Germany, vaccination against poliomyelitis was introduced in 1962 using the oral polio vaccine (OPV containing Sabin strain LSc-2ab. The vaccination schedule was changed from OPV to an inactivated polio vaccine (IPV containing wild polio virus type 1 strain Mahoney in 1998. In the present study, we assessed potential differences in neutralising antibody titres to Sabin and CHAT in persons with a history of either OPV, IPV, or OPV with IPV booster. Methods Neutralisation poliovirus antibodies against CHAT and Sabin 1 were measured in sera of 41 adults vaccinated with OPV. Additionally, sera from 28 children less than 10 years of age and immunised with IPV only were analysed. The neutralisation assay against poliovirus was performed according to WHO guidelines. Results The neutralisation activity against CHAT in adults with OPV vaccination history was significantly lower than against Sabin poliovirus type 1 strains (Wilcoxon signed-rank test P Conclusion The lack of neutralising antibodies against the CHAT strain in persons vaccinated with OPV might be associated with an increased risk of reinfection with the CHAT polio virus type 1, and this implies a putative risk of transmission of the virus to polio-free communities. We strongly suggest that laboratory workers who were immunised with OPV receive a booster vaccination with IPV before handling CHAT in the laboratory.

  2. Sabin and wild type polioviruses from children who presented with acute flaccid paralysis in Nigeria.

    Science.gov (United States)

    Adedeji, A O; Okonko, I O; Adu, F D

    2012-09-01

    Sensitive poliovirus surveillance to detect vaccine-derived-polioviruses will continue to increase in importance. Isolating and identifying poliovirus strains from children of pediatrics age in Nigeria. A total of 120 fecal samples were randomly collected from children under the age of five who presented with acute flaccid paralysis. Samples were tested by tissue culture technique and further characterized by intratypic differentiation testing using ELISA and PCR methods. The study confirmed the presence of 22(18.3%) enteroviral isolates comprising 19(86.4%) polioviruses and 3(13.6%) non-polio enteroviruses. These 19 polioviruses include: Sabin-type poliovirus-1 (15.8%), poliovirus-2 (10.5%), poliovirus-3 (10.5%) and wild-type poliovirus-1 (63.2%) isolates. It showed that poliovirus infection was higher in children ages 6-11 months (18.9%), females (18.4%), northern states (91.0%) with no vaccination record (75.0%). Wild-type poliovirus-1 was isolated from the stool samples of 12(54.6%) children from northern states and in all age groups except 18-23 months. No significant differences (P >0.05) between poliovirus infection and age (18.9% vs. 17.7%; 81.9% vs. 18.2%) and sex (18.3% vs. 18.4%). There was significant differences (Pvaccination (75.0% vs. 0.0%). No wild-type poliovirus was found in those with complete vaccination. This study further confirms the presence of Sabin and wild-type poliovirus among children in Nigeria. The isolation of Sabin strain of poliovirus is advantageous to the polio eradication program as it is capable of inducing natural immunity in susceptible hosts. Transmission of wild-type poliovirus among children with incomplete vaccination poses a serious threat to polio eradication program in Nigeria. Environmental and serological surveillance with larger sample size are important for monitoring poliovirus circulation in Nigeria.

  3. Sabin and wild polioviruses from apparently healthy primary school children in northeastern Nigeria.

    Science.gov (United States)

    Baba, M M; Oderinde, B S; Patrick, P Z; Jarmai, M M

    2012-02-01

    Despite significant success of the Global Polio Eradication Initiative (GPEI) in Nigeria, Afghanistan, India, Pakistan, wild poliovirus still occurs due to persistently high proportions of under and unimmunized children. The study aimed at determining the type of poliovirus often excreted into the environment. Four hundred nine fecal samples collected from apparently healthy school children aged 5-16 years in Borno and Adamawa States, northeastern Nigeria, were tested for poliovirus by tissue culture technique. The isolates were characterized further by intratypic differentiation testing and genetic sequencing. Three wild poliovirus type, 11 Sabin type, combination of Sabin-types 1 + 2 and 2 + 3 poliovirus, and 22 non-polio enteroviruses were obtained. The continued excretion of wild-type poliovirus among children above 5 years old vaccinated with oral polio vaccine contributes to the persistent circulation of these viruses in the environment and may limit the population immunity. However, the excreted Sabin poliovirus is capable of immunizing the unvaccinated children and promotes herd immunity. Similarly, the excretion of combination of two polio serotypes indicates the child susceptibility to the missing serotype (s) and therefore indicates an immunity gap. The common unhygienic practices in the environment could aid the spread of these viruses through oral-fecal route. Asymptomatic transmission of wild poliovirus among older oral polio vaccine-vaccinated children poses a serious threat to polio eradication program in Nigeria and therefore, environmental and serological surveillance with larger sample size are important for monitoring poliovirus circulation in Nigeria. Copyright © 2011 Wiley Periodicals, Inc.

  4. TFpredict and SABINE: sequence-based prediction of structural and functional characteristics of transcription factors.

    Directory of Open Access Journals (Sweden)

    Johannes Eichner

    Full Text Available One of the key mechanisms of transcriptional control are the specific connections between transcription factors (TF and cis-regulatory elements in gene promoters. The elucidation of these specific protein-DNA interactions is crucial to gain insights into the complex regulatory mechanisms and networks underlying the adaptation of organisms to dynamically changing environmental conditions. As experimental techniques for determining TF binding sites are expensive and mostly performed for selected TFs only, accurate computational approaches are needed to analyze transcriptional regulation in eukaryotes on a genome-wide level. We implemented a four-step classification workflow which for a given protein sequence (1 discriminates TFs from other proteins, (2 determines the structural superclass of TFs, (3 identifies the DNA-binding domains of TFs and (4 predicts their cis-acting DNA motif. While existing tools were extended and adapted for performing the latter two prediction steps, the first two steps are based on a novel numeric sequence representation which allows for combining existing knowledge from a BLAST scan with robust machine learning-based classification. By evaluation on a set of experimentally confirmed TFs and non-TFs, we demonstrate that our new protein sequence representation facilitates more reliable identification and structural classification of TFs than previously proposed sequence-derived features. The algorithms underlying our proposed methodology are implemented in the two complementary tools TFpredict and SABINE. The online and stand-alone versions of TFpredict and SABINE are freely available to academics at http://www.cogsys.cs.uni-tuebingen.de/software/TFpredict/ and http://www.cogsys.cs.uni-tuebingen.de/software/SABINE/.

  5. A national reference for inactivated polio vaccine derived from Sabin strains in Japan.

    Science.gov (United States)

    Shirato, Haruko; Someya, Yuichi; Ochiai, Masaki; Horiuchi, Yoshinobu; Takahashi, Motohide; Takeda, Naokazu; Wakabayashi, Kengo; Ouchi, Yasumitsu; Ota, Yoshihiro; Tano, Yoshio; Abe, Shinobu; Yamazaki, Shudo; Wakita, Takaji

    2014-09-08

    As one aspect of its campaign to eradicate poliomyelitis, the World Health Organization (WHO) has encouraged development of the inactivated polio vaccine (IPV) derived from the Sabin strains (sIPV) as an option for an affordable polio vaccine, especially in low-income countries. The Japan Poliomyelitis Research Institute (JPRI) inactivated three serotypes of the Sabin strains and made sIPV preparations, including serotypes 1, 2 and 3 D-antigens in the ratio of 3:100:100. The National Institute of Infectious Diseases, Japan, assessed the immunogenic stability of these sIPV preparations in a rat potency test, according to an evaluation method recommended by the WHO. The immunogenicity of the three serotypes was maintained for at least 4 years when properly stored under -70°C. Based on these data, the sIPV preparations made by JPRI have been approved as national reference vaccines by the Japanese national control authority and used for the quality control of the tetracomponent sIPV-containing diphtheria-tetanus-acellular pertussis combination vaccines that were licensed for a routine polio immunization in Japan. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Innovative IPV from attenuated Sabin poliovirus or newly designed alternative seed strains.

    Science.gov (United States)

    Hamidi, Ahd; Bakker, Wilfried A M

    2012-11-01

    This article gives an overview of the patent literature related to innovative inactivated polio vaccine (i-IPV) based on using Sabin poliovirus strains and newly developed alternative recombinant poliovirus strains. This innovative approach for IPV manufacturing is considered to attribute to the requirement for affordable IPV in the post-polio-eradication era, which is on the horizon. Although IPV is a well-established vaccine, the number of patent applications in this field was seen to have significantly increased in the past decade. Currently, regular IPV appears to be too expensive for universal use. Future affordability may be achieved by using alternative cell lines, alternative virus seed strains, improved and optimized processes, dose sparing, or the use of adjuvants. A relatively short-term option to achieve cost-price reduction is to work on regular IPV, using wild-type poliovirus strains, or on Sabin-IPV, based on using attenuated poliovirus strains. This price reduction can be achieved by introducing efficiency in processing. There are also multiple opportunities to work on dose sparing, for example, by using adjuvants or fractional doses. Renewed interest in this field was clearly reflected in the number and diversity of patent applications. In a later stage, several innovative approaches may become even more attractive, for example the use of recombinant virus strains or even a totally synthetic vaccine. Currently, such work is mainly carried out by research institutes and universities and therefore clinical data are not available.

  7. Antioxidant Properties of Crude Extract, Partition Extract, and Fermented Medium of Dendrobium sabin Flower

    Directory of Open Access Journals (Sweden)

    Farahziela Abu

    2017-01-01

    Full Text Available Antioxidant properties of crude extract, partition extract, and fermented medium from Dendrobium sabin (DS flower were investigated. The oven-dried DS flower was extracted using 100% methanol (w/v, 100% ethanol (w/v, and 100% water (w/v. The 100% methanolic crude extract showed the highest total phenolic content (40.33 ± mg GAE/g extract and the best antioxidant properties as shown by DPPH, ABTS, and FRAP assays. A correlation relationship between antioxidant activity and total phenolic content showed that phenolic compounds were the dominant antioxidant components in this flower extract. The microbial fermentation on DS flower medium showed a potential in increasing the phenolic content and DPPH scavenging activity. The TPC of final fermented medium showed approximately 18% increment, while the DPPH of fermented medium increased significantly to approximately 80% at the end of the fermentation. Dendrobium sabin (DS flower showed very good potential properties of antioxidant in crude extract and partition extract as well as better antioxidant activity in the flower fermented medium.

  8. Safety and immunogenicity of inactivated poliovirus vaccine made from Sabin strains: a phase II, randomized, positive-controlled trial.

    Science.gov (United States)

    Liao, Guoyang; Li, Rongcheng; Li, Changgui; Sun, Mingbo; Li, Yanping; Chu, Jiayou; Jiang, Shude; Li, Qihan

    2012-01-15

    The production of Sabin inactivated poliovirus vaccine (IPV) can reduce biosafety requirements in the posteradication/post-oral poliovirus vaccine (OPV) era. We conducted a phase II, randomized, positive-controlled trial to assess the safety and immunogenicity of Sabin IPV. The test groups (A, B, and C) received 3 doses of high, middle, and low D antigen (D Ag) of Sabin IPV at ages 2, 3, and 4 months, respectively. Infants in 2 control groups, group D and group E, received 3 doses of trivalent OPV and conventional IPV (cIPV), respectively, on the same schedule as that of groups A, B, and C. Serum samples were collected before and 30 days after the administration of the third dose. In total, 500 infants were randomly assigned to 5 groups, and 449 infants completed the vaccine series. No serious adverse events were associated with vaccinations. After 3 doses, the seroconversion rates in groups A, B, C, D, and E were 100%, 97.8%, 96.6%, 100%, and 90.1%, respectively, for type 1 poliovirus; 97.7%, 95.7%, 78.7%, 100%, and 90.1%, respectively, for type 2; and 98.8%, 98.9%, 93.3%, 100%, and 97.8%, respectively, for type 3. Sabin IPV has good safety characteristics. The seroconversion rates for type 1 poliovirus (most appropriate concentration, 15 D Ag units [DU]), type 2 (32 DU), and type 3 (45 DU) Sabin IPV were similar to those of the OPV and cIPV control groups. NCT01056705.

  9. Approssimazione all’edizione italiana della Cronica generale d’Hispagna et del regno di Valenza di Pere Antoni Beuter (Venezia, Gabriele Giolito de’ Ferrari, 1556: l’esemplare della “Biblioteca Civica” di Verona

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    Paola Bellomi

    2013-06-01

    Full Text Available Riassunto: Il presente saggio si propone come una prima approssimazione allo studio dell’edizioneitaliana della Cronaca generale d’Hispagna et del regno di Valenza di Pere Antoni Beuter, pubblicatanel 1556 a Venezia da Gabriele Giolito de’ Ferrari nella traduzione dello spagnolo Alfonso deUlloa. Quest’opera storiografica si inserisce in un contesto culturale importantissimo come quellodella Venezia del Cinquecento, particolarmente effervescente nel campo dell’editoria con figure diprim’ordine come Giolito e Ulloa. Il saggio si divide in tre momenti: il primo è costituito da unabreve introduzione sull’opera di Beuter e sulla traduzione di Ulloa; il secondo presenta la schedacatalografica dell’esemplare conservato presso la Biblioteca Civica di Verona; infine il terzo esponesinteticamente i contenuti della Cronaca.Parole chiave: Pere Antoni Beuter, Alfonso de Ulloa, Gabriele Giolito de’ Ferrari, Cronaca generaled’Hispagna et del regno di ValenzaAbstract: This essay is an approximation to the study of the the Italian edition of Pere AntoniBeuter’s Cronica generale d’Hispagna et del regno di Valenza, translated by the Spaniard Alfonso de Ulloa and published in Venice in 1556 by Gabriele Giolito de’ Ferrari. This chronicle is part of a majorcultural context, that of the Venice of the XVI century, very active in the emerging publishingbusiness with personalities such as Giolito and Ulloa. The essay is divided into three sections: 1. ashort introduction about the author and the translator; 2. the analytic description of the copy ofthe «Biblioteca Civica di Verona»; 3. the summaries of the contents of the Cronaca generale.Keywords: Pere Antoni Beuter, Alfonso de Ulloa, Gabriele Giolito de’ Ferrari, Cronaca generaled’Hispagna et del regno di Valenza, Biblioteca Civica di Verona

  10. [The role of Sabin inactivated poliovirus vaccine in the final phase of global polio eradication].

    Science.gov (United States)

    Dong, S Z; Zhu, W B

    2016-12-06

    Global polio eradication has entered its final phase, but still faces enormous challenges. The Polio Eradication and Endgame Strategic Plan (2013-2018) set the target for making the world polio-free by 2018. Meanwhile, the World Heath Organization Global Action Plan (GAP Ⅲ) recommended that polioviruses be stored under strict conditions after eradication of the wild poliovirus. At least one dose of inactivated poliovirus vaccine (IPV) would be required for each newborn baby in the world to ensure successful completion of the final strategy and GAP Ⅲ. The Sabin IPV has a high production safety and low production cost, compared with the wild-virus IPV and, therefore, can play an important role in the final stage of global polio eradication.

  11. Antigen sparing with adjuvanted inactivated polio vaccine based on Sabin strains.

    Science.gov (United States)

    Westdijk, Janny; Koedam, Patrick; Barro, Mario; Steil, Benjamin P; Collin, Nicolas; Vedvick, Thomas S; Bakker, Wilfried A M; van der Ley, Peter; Kersten, Gideon

    2013-02-18

    Six different adjuvants, each in combination with inactivated polio vaccine (IPV) produced with attenuated Sabin strains (sIPV), were evaluated for their ability to enhance virus neutralizing antibody titres (VNTs) in the rat potency model. The increase of VNTs was on average 3-, 15-, 24-fold with adjuvants after one immunization (serotypes 1, 2, and 3, respectively). Also after a boost immunization the VNTs of adjuvanted sIPV were on average another 7-20-27 times higher than after two inoculations of sIPV without adjuvant. The results indicate that it is feasible to increase the potency of inactivated polio vaccines by using adjuvants. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Iris Wigger and Sabine Ritter, editors. Racism and Modernity. Festschrift for Wulf D. Hund

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    Hernán Andrés Pulido Londoño

    2012-07-01

    Full Text Available Este volumen, editado por Iris Wigger y Sabine Ritter, reúne diecisiete ensayos hermanados por la reflexión conceptual e historiográfica sobre las prácticas y discursos racistas que apuntalaron la emergencia de las sociedades modernas. La colección honra los aportes académicos de Wulf D. Hund (1946, destacado investigador alemán, quien ha desarrollado fructíferos análisis críticos dedicados —como señalan las editoras— a una disección histórico-sociológica de los discursos raciales en el pensamiento europeo y la historia global. En efecto, esta colección está estrechamente relacionada con una de las propuestas centrales de Hund: el examen de los racismos como parte de procesos de socialización negativa consustanciales a la modernidad.

  13. Safety and immunogenicity of a primary series of Sabin-IPV with and without aluminum hydroxide in infants.

    Science.gov (United States)

    Verdijk, Pauline; Rots, Nynke Y; van Oijen, Monique G C T; Weldon, William C; Oberste, M Steven; Okayasu, Hiromasa; Sutter, Roland W; Bakker, Wilfried A M

    2014-09-03

    An inactivated poliovirus vaccine (IPV) based on attenuated poliovirus strains (Sabin-1, -2 and -3) was developed for technology transfer to manufacturers in low- and middle-income countries in the context of the global polio eradication initiative. Safety and immunogenicity of Sabin-IPV (sIPV) was evaluated in a double-blind, randomized, controlled, dose-escalation trial in the target population. Healthy infants (n=20/group) aged 56-63 days, received a primary series of three intramuscular injections with low-, middle- or high-dose sIPV with or without aluminum hydroxide or with the conventional IPV based on wild poliovirus strains (wIPV). Virus-neutralizing titers against both Sabin and wild poliovirus strains were determined before and 28 days after three vaccinations. The incidence of local and systemic reactions was comparable with the wIPV. Seroconversion rates after three vaccinations were 100% for type 2 and type 3 polioviruses (both Sabin and wild strains) and 95-100% for type 1 polioviruses. Median titers were high in all groups. Titers were well above the log2(titer) correlated with protection (=3) for all groups. Median titers for Sabin-2 were 9.3 (range 6.8-11.5) in the low-dose sIPV group, 9.2 (range 6.8-10.2) in the low-dose adjuvanted sIPV group and 9.8 (range 5.5-15.0) in the wIPV group, Median titers against MEF-1 (wild poliovirus type 2) were 8.2 (range 4.8-10.8) in the low-dose sIPV group, 7.3 (range 4.5-10.2) in the low-dose adjuvanted Sabin-IPV group and 10.3 (range 8.5-17.0) in the wIPV group. For all poliovirus types the median titers increased with increasing dose levels. sIPV and sIPV adjuvanted with aluminum hydroxide were immunogenic and safe at all dose levels, and comparable with the wIPV. EudraCTnr: 2011-003792-11, NCT01709071. Copyright © 2014. Published by Elsevier Ltd.

  14. [History of development of the live poliomyelitis vaccine from Sabin attenuated strains in 1959 and idea of poliomyelitis eradication].

    Science.gov (United States)

    Lashkevich, V A

    2013-01-01

    In 1958 Poliomyelitis Institute in Moscow and Institute of Experimental Medicine in St. Petersburg received from A. Sabin the attenuated strains of poliomyelitis virus. The characteristics of the strains were thoroughly studied by A. A. Smorodintsev and coworkers. They found that the virulence of the strains fluctuated slightly in 10 consecutive passages through the intestine of the non-immune children. A part of the Sabin material was used by A. A. Smorodintsev and M. P. Chumakov in the beginning of 1959 for immunizing approximately 40000 children in Estonia, Lithuania, and Latvia. Epidemic poliomyelitis rate in these republics decreased from approximately 1000 cases yearly before vaccination to less than 20 in the third quarter of 1959. This was a convincing proof of the efficacy and safety of the vaccine from the attenuated Sabin strains. In 1959, according to A. Sabin's recommendation, a technology of live vaccine production was developed at the Poliomyelitis Institute, and several experimental lots of vaccine were prepared. In the second part of 1959, 13.5 million children in USSR were immunized. The epidemic poliomyelitis rate decreased 3-5 times in different regions without paralytic cases, which could be attributed to the vaccination. These results were the final proof of high efficiency and safety of live poliomyelitis vaccine from the attenuated Sabin strains. Based on these results, A. Sabin and M. P. Chumakov suggested in 1960 the idea of poliomyelitis eradication using mass immunization of children with live vaccine. 72 million persons up to 20 years old were vaccinated in USSR in 1960 with a 5 times drop in the paralytic rate. 50-year-long use of live vaccine results in poliomyelitis eradication in almost all countries worldwide. More than 10 million children were rescued from the death and palsy. Poliomyelitis eradication in a few countries where it still exists depends not on medical services but is defined by the attitude of their leaders to fight

  15. [From the Auschwitz Syndrome to a Psyche Model--Life and Work of the Polish Psychiatrist Antoni Kepinski (1918-1972)].

    Science.gov (United States)

    Schochow, Maximilian; Willer, Manuel; Steger, Florian

    2016-01-01

    Life and work of the Polish psychiatrist Antoni Kepinski (1918 - 1972) are barely known today, although his writings about the Auschwitz syndrome have had an impact all over the world. We present his biography and work. Compilation and evaluation of literature about Kepinski's work and historical-critical analysis of his key texts. Kepinski's work about the Auschwitz syndrome formed the basis for his understanding of the psyche and his theory on information metabolism. Kepinski posited that the mind processes outside stimuli based on its own set of values and that it determines the subject's actions. In doing so, it affects its environment. If these interactions are disrupted, pathological disorders might result. The therapist should consequently empower the patient to get in touch with his own value-system. Kepinskis work serves as a foundation for research on disease patterns that are known today as post-traumatic stress disorder (PTSD). His theory on information metabolism is essential for the current treatment of patients. It is therefore important to further explore his work and adjust it to the requirements of medical practice. © Georg Thieme Verlag KG Stuttgart · New York.

  16. Nucleotide variation in Sabin type 3 poliovirus from an Albanian infant with agammaglobulinemia and vaccine associated poliomyelitis.

    Science.gov (United States)

    Foiadelli, Thomas; Savasta, Salvatore; Battistone, Andrea; Kota, Majlinda; Passera, Carolina; Fiore, Stefano; Bino, Silvia; Amato, Concetta; Lozza, Alessandro; Marseglia, Gian Luigi; Fiore, Lucia

    2016-06-10

    Vaccine-associated paralytic poliomyelitis (VAPP) and immunodeficient long-term polio excretors constitute a significant public health burden and are a major concern for the WHO global polio eradication endgame. Poliovirus type 3 characterized as Sabin-like was isolated from a 5-month-old Albanian child with X-linked agammaglobulinemia and VAPP after oral polio vaccine administration. Diagnostic workup and treatment were performed in Italy. Poliovirus replicated in the gut for 7 months. The 5' non coding region (NCR), VP1, VP3 capsid proteins and the 3D polymerase genomic regions of sequential isolates were sequenced. Increasing accumulation of nucleotide mutations in the VP1 region was detected over time, reaching 1.0 % of genome variation with respect to the Sabin reference strain, which is the threshold that defines a vaccine-derived poliovirus (VDPV). We identified mutations in the 5'NCR and VP3 regions that are associated with reversion to neurovirulence. Despite this, all isolates were characterized as Sabin-like. Several amino acid mutations were identified in the VP1 region, probably involved in growth adaptation and viral persistence in the human gut. Intertypic recombination with Sabin type 2 polio in the 3D polymerase region, possibly associated with increased virus transmissibility, was found in all isolates. Gamma-globulin replacement therapy led to viral clearance and neurological improvement, preventing the occurrence of persistent immunodeficiency-related VDPV. This is the first case of VAPP in an immunodeficient child detected in Albania through the Acute Flaccid Paralysis surveillance system and the first investigated case of vaccine associated poliomyelitis in Italy since the introduction of an all-Salk schedule in 2002. We discuss over the biological and clinical implications in the context of the Global Polio Eradication Program and emphasize on the importance of the Acute Flaccid Paralysis surveillance.

  17. Atividade Antinociceptiva e Antimicrobiana da Casca do Caule de Psidium Cattleyanum Sabine

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    F.Q. ALVARENDA

    2015-01-01

    Full Text Available RESUMO Psidium cattleyanum Sabine, conhecida como “araçá”, é espécie nativa do Bioma Cerrado brasileiro comumente utilizado, segundo levantamento etnobotânico, como planta medicinal para tratar várias doenças tais como: patologias hepáticas, gástricas, lesões teciduais incluindo processos dolorosos. O objetivo deste trabalho foi realizar a triagem fitoquímica com propósito exploratório, investigar a atividade analgésica e antimicrobiana do extrato hidroalcoólico da casca do caule de Psidium cattleyanum Sabine (ECPCS para apoiar o uso dessa espécie como planta medicinal. Para isso, foram obtidos extratos e frações com solventes orgânicos de polaridade crescente (hexano, diclorometano, acetato de etila e isobutanol avaliando-se o perfil fitoquímico para determinar as principais classes de metabólitos secundários presentes na espécie. Investigou-se a atividade analgésica pelo teste de contorções abdominais em camundongos induzidas pelo ácido acético (0,6%. A Concentração Inibitória Mínina (CIM e Concentração Bactericida Mínima (CBM foram avaliadas através da técnica de microdiluição em caldo contra micro-organismos da microbiota oral. A triagem fitoquímica identificou a presença de taninos, saponinas, flavonoides e terpenos e/ou esteroides. O ECPCS exibiu atividade analgésica periférica nas doses de 200 e 400 mg/kg. O EAC (extrato acetato de casca o EDC (extrato diclorometânico de casca desempenharam melhor ação inibitória sobre o crescimento bacteriano de Estafilococos oralis com CIM 100 e 150 respectivamente. O ECPCS desempenhou ação inibitória sobre o crescimento bacteriano. Os resultados dos estudos experimentais comprovaram a presença de compostos secundários tais como, taninos e flavonoides, o que, provavelmente, pode ser associado à atividade analgésica e ao efeito inibitório sobre os micro-organismos testados com o ECPCS, o que justifica o uso medicinal planta.

  18. Phenotypic and genomic analysis of serotype 3 Sabin poliovirus vaccine produced in MRC-5 cell substrate.

    Science.gov (United States)

    Alirezaie, Behnam; Taqavian, Mohammad; Aghaiypour, Khosrow; Esna-Ashari, Fatemeh; Shafyi, Abbas

    2011-05-01

    The cell substrate has a pivotal role in live virus vaccines production. It is necessary to evaluate the effects of the cell substrate on the properties of the propagated viruses, especially in the case of viruses which are unstable genetically such as polioviruses, by monitoring the molecular and phenotypical characteristics of harvested viruses. To investigate the presence/absence of mutation(s), the near full-length genomic sequence of different harvests of the type 3 Sabin strain of poliovirus propagated in MRC-5 cells were determined. The sequences were compared with genomic sequences of different virus seeds, vaccines, and OPV-like isolates. Nearly complete genomic sequencing results, however, revealed no detectable mutations throughout the genome RNA-plaque purified (RSO)-derived monopool of type 3 OPVs manufactured in MRC-5. Thirty-six years of experience in OPV production, trend analysis, and vaccine surveillance also suggest that: (i) different monopools of serotype 3 OPV produced in MRC-5 retained their phenotypic characteristics (temperature sensitivity and neuroattenuation), (ii) MRC-5 cells support the production of acceptable virus yields, (iii) OPV replicated in the MRC-5 cell substrate is a highly efficient and safe vaccine. These results confirm previous reports that MRC-5 is a desirable cell substrate for the production of OPV. Copyright © 2011 Wiley-Liss, Inc.

  19. PENGARUH TEMPERATUR DAN WAKTU PENYIMPANAN TERHADAP POTENSI VAKSIN POLIO ORAL TRIVALEN (SABIN TYPE

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    Djoko Yuwono

    2012-09-01

    Full Text Available The effect of temperature and duration of storage on the potency of trivalent oral polio vaccine (Sabin type were investigated. Temperature was set up at the beginning from : —20 C, 0 C, 5 C, 10 C, 15°C, 25 C and 30°C. During 30 days period of storage, the polio virus was titrated at 4 days interval using micromethod of TCID5 0 calculation in Vero cells. The result of the study showed that the effect of -20°C, 0°C and 5°C for 30 days of storage was not significantly different. Whereas at 10°C the vaccine potency had started to decrease at day 24 up to day 30. At 15°C the potency had started to decrease at day 12, while at 25°C and 30°C the potency of vaccine drooed sharply at day 4 of storage.

  20. Cambios en la Actividad Antioxidante Durante el Desarrollo de Frutos de Psidium cattleianum Sabine (Myrtaceae / Changes in the Antioxidant Activity During the Development in Fruits of Psidium cattleianum Sabine (Myrtaceae

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    Villacorta Lozano Verónica

    2013-08-01

    Full Text Available Resumen. Psidium cattleianum Sabine, conocida como casdulce, guayaba japonesa, guayaba peruana y guayaba fresa, es un árbol originario de América del Sur. Estudios preliminares en esta especie han sugerido una elevada actividad antioxidante, un alto contenido fenólico y un gran potencial nutricional y funcional. En esta investigación se analizó la evolución de varios componentes del sistema de defensa antioxidante no enzimático, durante el crecimiento y maduración de los frutos de Psidium cattleianum Sabine. El periodo de crecimiento de los frutos presentó la actividad antioxidante más elevada, medida a través de las técnicas TEAC-DPPH y TEAC-ABTS (Trolox equivalent antioxidant capacity, FRAP (Ferric reducing/antioxidant powery ORAC (Oxigen Radical Absorbance Capacity, así como elcontenido máximo de fenoles totales, entre los que destacaron los ácidos clorogénico, cafeico y p-coumárico, y de sustancias no polifenólicas como el ácido ascórbico. Durante el periodo de maduración, se observó una disminución de la actividad antioxidante, posiblemente promovida por la pérdida gradual de algunos compuestos polifenólicos, así como también, debido a la aparición de otros compuestos como las antocianinas. Los resultados mostraron que estos frutos contienen un alto contenido de sustancias con actividad antioxidante, lo cual soporta el desarrollo de esta especie como nueva alternativa productiva / Abstract. Psidium cattleianum Sabine, known as cas sweet, japanese guava, peruvian guava and strawberry guava, is a tree native to South America. Preliminary studies in this specieshave suggested a high antioxidant activity, a high phenoliccontent and great nutritional and functional potential. In thisstudy, the evolution of some components of the non-enzimatic antioxidant defense system was analized during growth and ripening of fruit of Psidium cattleianum Sabine. The growing period of the fruits presented the highest antioxidant

  1. A RT-PCR method for selective amplification and phenotypic characterization of all three serotypes of Sabin-related polioviruses from viral mixtures

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    Eliane Veiga da Costa

    2012-08-01

    Full Text Available Outbreaks caused by vaccine-derived polioviruses are challenging the final eradication of paralytic poliomyelitis. Therefore, the surveillance of the acute flaccid paralysis cases based on poliovirus isolation and characterization remains an essential activity. Due to the use of trivalent oral poliovirus vaccine (OPV, mixtures containing more than one serotype of Sabin-related polioviruses are frequently isolated from clinical samples. Because each poliovirus isolate needs to be individually analyzed, we designed polymerase chain reaction primers that can selectively distinguish and amplify a genomic segment of the three Sabin-related poliovirus serotypes present in mixtures, thus, optimizing the diagnosis and providing prompt information to support epidemiologic actions.

  2. Evolution of the Sabin vaccine into pathogenic derivatives without appreciable changes in antigenic properties: need for improvement of current poliovirus surveillance.

    Science.gov (United States)

    Yakovenko, Maria L; Korotkova, Ekaterina A; Ivanova, Olga E; Eremeeva, Tatyana P; Samoilovich, Elena; Uhova, Iryna; Gavrilin, Gene V; Agol, Vadim I

    2009-04-01

    The Sabin oral polio vaccine (OPV) may evolve into pathogenic viruses, causing sporadic cases and outbreaks of poliomyelitis. Such vaccine-derived polioviruses (VDPV) generally exhibit altered antigenicity. The current paradigm to distinguish VDPV from OPV and wild polioviruses is to characterize primarily those poliovirus isolates that demonstrate deviations from OPV in antigenic and genetic intratypic differentiation (ITD) tests. Here we report on two independent cases of poliomyelitis caused by VDPVs with "Sabin-like" properties in several ITD assays. The results suggest the existence of diverse pathways of OPV evolution and necessitate improvement of poliovirus surveillance, which currently potentially misses this class of VDPV.

  3. The Mock-up of the "Ratto Delle Sabine" by Giambologna: Making and Utilization of a 3D Model

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    Grazia Tucci

    2015-02-01

    Full Text Available Within a project for the knowledge and preservation of the mock-up of Giambologna's Ratto delle Sabine housed in the Galleria dell'Accademia in Florence, the GeCO laboratory has made laser scanner acquisitions to create surface models at different resolutions for structural analysis, on which to check the coverage of the photographic campaign and to create a three-dimensional thematic mapping of data relating to investigations and restoration works. The PDF3D file format has been used to easily manage data on a platform immediately available to all operators.

  4. The Effect of Formulation on Spray Dried Sabin Inactivated Polio Vaccine.

    Science.gov (United States)

    Kanojia, Gaurav; Ten Have, Rimko; Brugmans, Debbie; Soema, Peter C; Frijlink, Henderik W; Amorij, Jean-Pierre; Kersten, Gideon

    2018-05-19

    The objective of this study was to develop a stable spray dried formulation, containing the three serotypes of Sabin inactivated polio vaccine (sIPV), aiming for minimal loss of native conformation (D-antigen) during drying and subsequent storage. The influence of atomization and drying stress during spray drying on trivalent sIPV was investigated. This was followed by excipient screening, in which monovalent sIPV was formulated and spray dried. Excipient combinations and concentrations were tailored to maximize both the antigen recovery of respective sIPV serotypes after spray drying and storage (T= 40°C and t= 7 days). Furthermore, a fractional factorial design was developed around the most promising formulations to elucidate the contribution of each excipient in stabilizing D-antigen during drying. Serotype 1 and 2 could be dried with 98 % and 97 % recovery, respectively. When subsequently stored at 40°C for 7 days, the D-antigenicity of serotype 1 was fully retained. For serotype 2 the D-antigenicity dropped to 71 %. Serotype 3 was more challenging to stabilize and a recovery of 56 % was attained after drying, followed by a further loss of 37 % after storage at 40°C for 7 days. Further studies using a design of experiments approach demonstrated that trehalose/monosodium glutamate and maltodextrin/arginine combinations were crucial for stabilizing serotype 1 and 2, respectively. For sIPV serotype 3, the best formulation contained Medium199, glutathione and maltodextrin. For the trivalent vaccine it is therefore probably necessary to spray dry the different serotypes separately and mix the dry powders afterwards to obtain the trivalent vaccine. Copyright © 2018. Published by Elsevier B.V.

  5. In vivo analgesic activity, toxicity and phytochemical screening of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine.

    Science.gov (United States)

    Alvarenga, Felipe Queiroz; Mota, Bárbara C F; Leite, Marcel N; Fonseca, Jaciara M S; Oliveira, Dario A; Royo, Vanessa de Andrade; e Silva, Márcio L A; Esperandim, Viviane; Borges, Alexandre; Laurentiz, Rosangela S

    2013-10-28

    Psidium cattleianum Sabine is extensively used in Brazilian traditional medicine to treat several diseases including painful disorders. Aim of the study to investigate the toxicity and the possible analgesic activities of the hydroalcoholic extract from the leaves of Psidium cattleianum Sabine (ELPCS), to support its use in folk medicine. To screen the major phytochemical constituents of this extract and evaluate their antioxidant activity. ELPCS was assessed for its antioxidant activity using the DPPH model. Its analgesic activity was examined using mouse models of acetic acid-induced writhing and hot plate paw licking models. The major phytochemical constituents of the extract were screened; their toxicity on LLC-MK2 mammalian cells was evaluated. ELPCS exhibited significant peripheral analgesic activity at doses of 60, 80, 100, 200 and 400mg/kg in mice, but it did not display central analgesic activity and not was toxic to LLC-MK2 cell (LD50>400 µg/mL). The extract exhibited free radical scavenging activity as evidenced by IC50 values (15.9 µg/mL) obtained by the DPPH method. Phytochemical screening detected flavonoids, saponins, cardiac glycosides, anthraquinones, and tannins. The results of the experimental studies proved the analgesic activity of ELPCS and supported the traditional use of this plant. © 2013 Elsevier Ireland Ltd. All rights reserved.

  6. Analysis of the dose-sparing effect of adjuvanted Sabin-inactivated poliovirus vaccine (sIPV).

    Science.gov (United States)

    Li, Zhuofan; Ding, Wenting; Guo, Qi; Liu, Ze; Zhu, Zhe; Song, Shaohui; Li, Weidong; Liao, Guoyang

    2018-03-30

    Sabin-based inactivated poliovirus vaccine(sIPV) is gradually replacing live-attenuated oral polio vaccine(OPV). Sabin-inactivated poliovirus vaccine(sIPV) has played a vital role in reducing economic burden of poliomyelitis and maintaining appropriate antibody levels in the population. However, due to its high cost and limited manufacturing capacity, sIPV cannot reach its full potential for global poliovirus eradication in developing countries. Therefore, to address this situation, we designed this study to evaluate the dose-sparing effects of AS03, CpG oligodeoxynucleotides (CpG-ODN) and polyinosinic:polycytidylic acid (PolyI:C) admixed with sIPV in rats. Our results showed that a combination of 1/4-dose sIPV adjuvanted with AS03 or AS03 with BW006 provides a seroconversion rate similar to that of full-dose sIPV without adjuvant and that, this rate is 5-fold higher than that of 1/4-dose sIPV without adjuvant after the first immunization. The combination of AS03 or AS03 with BW006 as an adjuvant effectively reduced sIPV dose by at least 4-fold and induced both humoral and cellular immune responses. Therefore, our study revealed that the combination of AS03 or AS03 with BW006 is a promising adjuvant for sIPV development.

  7. Hydrologic modeling as a tool for land management and contingency planning in the Calcasieu Sabine Basin. Volume 1

    International Nuclear Information System (INIS)

    Myers, J.; Meselhe, E.; Kheiashy, K.; Miller, R.; Douglas, C.

    2007-01-01

    The Calcasieu-Sabine Basin in southwest Louisiana contains approximately 126,518 hectares of wetlands, consisting of fresh marsh, intermediate marsh, brackish marsh and saline marsh. The hydrodynamics of the basin involves a combination of estuarine processes such as saltwater intrusion, response to water level fluctuations at an open boundary and lake dynamics. The basin is also affected by deep ship channels. As such, a robust, flexible and efficient numerical model is needed to incorporate all of these processes in an operational program. This study developed a hydrodynamic and salinity model for a portion of the basin that includes the lakes and marshes for the purpose of land management and contingency planning. The newly developed finite-difference hydrodynamic and salinity model is a combination of 1 and 2 dimensional computations and is intended for land, wildlife and habitat management. It can be used as a coastal restoration tool to evaluate the effectiveness of future and ongoing coastal restoration projects. The model was calibrated and validated against field measurements. It was shown to produce accurate simulations of the complex flow patterns of the Calcasieu-Sabine Basin along with information on salinity, water level fluctuations, velocities and discharges throughout the main channels and open water bodies within the area. It was concluded that the model provides a very useful planning and adaptive management tool to improve the understanding of the complex hydrology and salinity circulation pattern within the system. 5 refs., 4 tabs., 9 figs

  8. Satellite-derived temperature data for monitoring water status in a floodplain forest of the Upper Sabine River, Texas

    Science.gov (United States)

    Lemon, Mary Grace T.; Allen, Scott T.; Edwards, Brandon L.; King, Sammy L.; Keim, Richard F.

    2016-01-01

    Decreased water availability due to hydrologic modifications, groundwater withdrawal, and climate change threaten bottomland hardwood (BLH) forest communities. We used satellite-derived (MODIS) land-surface temperature (LST) data to investigate spatial heterogeneity of canopy temperature (an indicator of plant-water status) in a floodplain forest of the upper Sabine River for 2008–2014. High LST pixels were generally further from the river and at higher topographic locations, indicating lower water-availability. Increasing rainfall-derived soil moisture corresponded with decreased heterogeneity of LST between pixels but there was weaker association between Sabine River stage and heterogeneity. Stronger dependence of LST convergence on rainfall rather than river flow suggests that some regions are less hydrologically connected to the river, and vegetation may rely on local precipitation and other contributions to the riparian aquifer to replenish soil moisture. Observed LST variations associated with hydrology encourage further investigation of the utility of this approach for monitoring forest stress, especially with considerations of climate change and continued river management.

  9. Dynamic profiles of neutralizing antibody responses elicited in rhesus monkeys immunized with a combined tetravalent DTaP-Sabin IPV candidate vaccine.

    Science.gov (United States)

    Sun, Mingbo; Ma, Yan; Xu, Yinhua; Yang, Huijuan; Shi, Li; Che, Yanchun; Liao, Guoyang; Jiang, Shude; Zhang, Shumin; Li, Qihan

    2014-02-19

    The World Health Organization has recommended that a Sabin inactivated polio vaccine (IPV) should gradually and synchronously replace oral polio vaccines for routine immunizations because its benefits in eliminating vaccine-associated paralytic poliomyelitis have been reported in different phases of clinical trials. It is also considered important to explore new tetravalent diphtheria, tetanus, and acellular pertussis-Sabin IPV (DTaP-sIPV) candidate vaccines for possible use in developing countries. In this study, the immunogenicity of a combined tetravalent DTaP-sIPV candidate vaccine was investigated in primates by evaluating the neutralizing antibody responses it induced. The dynamic profiles of the antibody responses to each of the separate antigenic components and serotypes of Sabin IPV were determined and their corresponding geometric mean titers were similar to those generated by the tetravalent diphtheria, tetanus, and acellular pertussis-conventional IPV (DTaP-cIPV), the tetravalent diphtheria, tetanus, and acellular pertussis (DTaP), and Sabin IPV vaccines in the control groups. This implies that protective immunogenic effects are conferred by this combined tetravalent formulation. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Arsenic Removal from Drinking Water by Iron Removal. U.S. EPA Demonstration Project at Sabin, MN. Six-Month Evaluation Report

    Science.gov (United States)

    This report documents the activities performed during and the results obtained from the first six months of the EPA arsenic removal technology demonstration project at the Sabin, MN. The main objective of the project is to evaluate the effectiveness of the Kinetico FM-248-AS ars...

  11. Arsenic Removal from Drinking Water by Iron Removal U.S. EPA Demonstration Project at Sabin, MN Final Performance Evaluation Report

    Science.gov (United States)

    This report documents the activities performed and the results obtained from January 30, 2006 to April 29, 2007 at the U.S. Environmental Protection Agency (EPA) Arsenic Removal Technology Demonstration site in Sabin, MN. The main objective of the project was to evaluate the eff...

  12. Sabine Dullin. La frontière épaisse: Aux origines des politiques soviétiques (1920-1940

    Directory of Open Access Journals (Sweden)

    Andrea Chandler

    2016-09-01

    Full Text Available Sabine Dullin. La frontière épaisse: Aux origines des politiques soviétiques (1920-1940. En temps & lieux 55. Paris: Éditions de l'École des hautes études en sciences sociales, 2014. 356 pp. Illustrations. Maps. Tables. Bibliography. Index of places. Index of names. Paper.

  13. Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model.

    Science.gov (United States)

    Arita, Minetaro; Ami, Yasushi; Wakita, Takaji; Shimizu, Hiroyuki

    2008-02-01

    Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and is also associated with serious neurological disorders. An attenuated EV71 strain [EV71(S1-3')] has been established in the cynomolgus monkey infection model; this strain contains the attenuation determinants derived from the type 1 poliovirus vaccine strain, Sabin 1 [PV1(Sabin)], in the 5' nontranslated region (NTR), 3D polymerase, and 3' NTR. In this study, we analyzed the effect of the attenuation determinants of PV1(Sabin) on EV71 infection in a NOD/SCID mouse infection model. We isolated a mouse-adapted EV71 strain [EV71(NOD/SCID)] that causes paralysis of the hind limbs in 3- to 4-week-old NOD/SCID mice by adaptation of the virulent EV71(Nagoya) strain in the brains of NOD/SCID mice. A single mutation at nucleotide 2876 that caused an amino acid change in capsid protein VP1 (change of the glycine at position 145 to glutamic acid) was essential for the mouse-adapted phenotype in NOD/SCID mice. Next, we introduced attenuation determinants derived from PV1(Sabin) along with the mouse adaptation mutation into the EV71(Nagoya) genome. In 4-week-old mice, the determinants in the 3D polymerase and 3' NTR, which are the major temperature-sensitive determinants, had a strong effect on attenuation. In contrast, the effect of individual determinants was weak in 3-week-old NOD/SCID mice, and all the determinants were required for substantial attenuation. These results suggest that a cooperative effect of the attenuation determinants of PV1(Sabin) is essential for attenuated neurovirulence of EV71.

  14. CpG oligodeoxynucleotides are a potent adjuvant for an inactivated polio vaccine produced from Sabin strains of poliovirus.

    Science.gov (United States)

    Yang, Chunting; Shi, Huiying; Zhou, Jun; Liang, Yanwen; Xu, Honglin

    2009-11-05

    Poliovirus transmission is controlled globally through world-wide use of a live attenuated oral polio vaccine (OPV). However, the imminence of global poliovirus eradication calls for a switch to the inactivated polio vaccine (IPV). Given the limited manufacturing capacity and high cost of IPV, this switch is unlikely in most developing and undeveloped countries. Adjuvantation is an effective strategy for antigen sparing. In this study, we evaluated the adjuvanticity of CpG oligodeoxynucleotides (CpG-ODN) for an experimental IPV produced from Sabin strains of poliovirus. Our results showed that CpG-ODN, alone or in combination with alum, can significantly enhance both the humoral and cellular immune responses to IPV in mice, and, consequently, the antigen dose could be reduced substantially. Therefore, our study suggests that the global use of IPV could be facilitated by using CpG-ODN or other feasible adjuvants.

  15. Acute flaccid paralysis surveillance in bosnia and herzegovina: Recent isolation of two sabin like type 2 poliovirus.

    Science.gov (United States)

    Fontana, Stefano; Buttinelli, Gabriele; Fiore, Stefano; Mulaomerovic, Mirsada; Aćimović, Jela; Amato, Concetta; Delogu, Roberto; Rezza, Giovanni; Stefanelli, Paola

    2017-09-01

    The WHO Regional Commission for the Certification of Poliomyelitis Eradication has recently indicated Bosnia and Herzegovina (B&H) as a high risk country for transmission, following importation, of wild poliovirus (WPV) or circulating vaccine-derived poliovirus (cVDPV). We analyzed data on Acute Flaccid Paralysis (AFP) surveillance between 2007 to 2016, and the trend of polio immunization coverage in B&H. The majority of AFP cases was recorded in 2016 suggesting an enhancement of the AFP surveillance activities. However, the decline in the immunization coverage, around 74%, and the isolation of two Sabin-like poliovirus type 2 strains, one of them close to a VDPV, require a particular attention in the area. Although B&H has successfully maintained its polio-free status since 2002 several challenges need to be addressed. © 2017 Wiley Periodicals, Inc.

  16. Germination et croissance initiale de Neocarya macrophylla (Sabine Prance, une espèce oléagineuse du Niger

    Directory of Open Access Journals (Sweden)

    Dan Guimbo, I.

    2011-01-01

    Full Text Available Germination and Initial Growth of Neocarya macrophylla (Sabine Prance, a oleaginous Species of Niger. The study conducted in parallel in the real environment, nursery and laboratory to better understand the characteristics of germination and seedling development Neocarya macrophylla, a species of oleaginous Niger. The treatments applied to seed have a waiting time shorter than the untreated seeds. The control has a staggered germination (30 days and shelling of nuts influenced seed germination bundled (16 days. Unprocessed nuts are the best germination rate (89.53%. Soaking nuts during 72 h and 120 h is fatal for germination. The shelf life has significant effects on the germination of walnuts and almonds. The observation shows a germinating seed cryptogeal. The low germination rates nuts without water shows that water is a limiting factor to the spread of this tree species. The seedlings are very sensitive to dampingoff and tolerant enough to transplantation with a survival rate of 79%.

  17. Comparative study of the volatile oil content and antimicrobial activity of Psidium guajava L. and Psidium cattleianum Sabine leaves

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    Fathy M. Soliman

    2016-12-01

    Full Text Available The chemical composition of the hydrodistilled oils of the leaves of Psidium guajava L. (guava leaf and Psidium cattleianum Sabine (strawberry guava was determined by GC/MS analysis to identify their chemotypes. Moreover, in vitro antimicrobial activity of these volatile oils against selected bacteria, yeast, and mycelia fungi was studied. The yield of the volatile oil hydrodistilled from the leaves of P. guajava L. and P. cattleianum Sabine was 1.6 and 2.69 g/kg on fresh weight basis, respectively. Limonene was the major identified hydrocarbon in P. guava leaves’ oil (54.70%, whereas, 1, 8-cineole was the major identified oxygenated monoterpenoid (32.14% in common guava leaves. The foliar oil of P. cattleianum was predominated by the sesquiterpene hydrocarbon; β-caryophyllene representing 28.83% of the total oil make-up. The antibacterial activity of guava leaf oil was more pronounced against Bacillus subtilis, Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa than that of strawberry guava leaves, while P. cattleianum showed a higher activity against ess. The MIC of the volatile oil of the leaves of P. guajava against S. aureus was 6.75 μg/ml, while that of P. cattleianum exhibited MIC value of 13.01 μg/ml against Neisseria gonorrhoeae. Results demonstrated that the volatile oil of both Psidium species showed different chemotypes. Moreover, the volatile oils of guava and strawberry guava leaves might be good candidates as antimicrobial agents.

  18. Detection of negative and positive RNA strand of poliovirus Sabin 1 and echovirus E19 by a stem-loop reverse transcription PCR.

    Science.gov (United States)

    Fikatas, A; Dimitriou, T G; Kyriakopoulou, Z; Moschonas, G D; Amoutzias, G D; Mossialos, D; Gartzonika, C; Levidiotou-Stefanou, S; Markoulatos, P

    2017-09-01

    In this report a strand specific RT-PCR was established for the detection of the replicative negative RNA strand of poliovirus sabin 1 (Sabin1) and Echovirus 19 (E19) strains. The key for the successful conduction of the assay was the use of a specific reverse transcription primer targeting the 5'-UTR of enteroviruses that consisted of a stem-loop structure at the 5'-end and an enteroviral-specific sequence at the 3'-end. The stem loop RT-PCR was found to be an accurate and sensitive method, detecting even 10 -2 CCID 50 of poliovirus sabin 1 (Sabin1) and E19 strains 6 h postinfection (p.i.), while CPE appeared 3 days later. This assay was also validated in SiHa and Caski cell lines that are not used for the detection of enteroviruses. The negative RNA strand was detected 6 h and 12 h p.i. in SiHa and Caski cells, when these cell lines were inoculated with 10 5 and 1 CCID 50 respectively, whereas CPE was observed 5 days p.i for SiHa cells and 8 days p.i for Caski cells and that only at 10 5 CCID 50 . The results show that this approach may be used for replacing the time-consuming cell cultures in order to detect the active replication of enteroviruses. Enteroviruses are positive stranded RNA viruses that may cause severe diseases. The conventional method for detection of active viral replication involves virus isolation in sensitive cell cultures followed by titration and seroneutralization. In this report, we describe the use of a stem-loop secondary structured oligonucleotide in RT-PCR assay for the detection of the replicative negative strand of the positive-stranded RNA of poliovirus sabin 1 and E19 strains. This approach proved to be a useful tool that may be used for replacing the time-consuming cell culture assays in order to detect the active replication of enteroviruses. © 2017 The Society for Applied Microbiology.

  19. Development of oral CTL vaccine using a CTP-integrated Sabin 1 poliovirus-based vector system.

    Science.gov (United States)

    Han, Seung-Soo; Lee, Jinjoo; Jung, Yideul; Kang, Myeong-Ho; Hong, Jung-Hyub; Cha, Min-Suk; Park, Yu-Jin; Lee, Ezra; Yoon, Cheol-Hee; Bae, Yong-Soo

    2015-09-11

    We developed a CTL vaccine vector by modification of the RPS-Vax system, a mucosal vaccine vector derived from a poliovirus Sabin 1 strain, and generated an oral CTL vaccine against HIV-1. A DNA fragment encoding a cytoplasmic transduction peptide (CTP) was integrated into the RPS-Vax system to generate RPS-CTP, a CTL vaccine vector. An HIV-1 p24 cDNA fragment was introduced into the RPS-CTP vector system and a recombinant poliovirus (rec-PV) named vRPS-CTP/p24 was produced. vRPS-CTP/p24 was genetically stable and efficiently induced Th1 immunity and p24-specific CTLs in immunized poliovirus receptor-transgenic (PVR-Tg) mice. In challenge experiments, PVR-Tg mice that were pre-immunized orally with vRPS-CTP/p24 were resistant to challenge with a lethal dose of p24-expressing recombinant vaccinia virus (rMVA-p24). These results suggested that the RPS-CTP vector system had potential for developing oral CTL vaccines against infectious diseases. Copyright © 2015 Elsevier Ltd. All rights reserved.

  20. Evaluation of the use of various rat strains for immunogenic potency tests of Sabin-derived inactivated polio vaccines.

    Science.gov (United States)

    Someya, Yuichi; Ami, Yasushi; Takai-Todaka, Reiko; Fujimoto, Akira; Haga, Kei; Murakami, Kosuke; Fujii, Yoshiki; Shirato, Haruko; Oka, Tomoichiro; Shimoike, Takashi; Katayama, Kazuhiko; Wakita, Takaji

    2018-03-01

    Slc:Wistar rats have been the only strain used in Japan for purpose of evaluating a national reference vaccine for the Sabin-derived inactivated polio vaccine (sIPV) and the immunogenicity of sIPV-containing products. However, following the discovery that the Slc:Wistar strain was genetically related to the Fischer 344 strain, other "real" Wistar strains, such as Crlj:WI, that are available worldwide were tested in terms of their usefulness in evaluating the immunogenicity of the past and current lots of a national reference vaccine. The response of the Crlj:WI rats against the serotype 1 of sIPV was comparable to that of the Slc:Wistar rats, while the Crlj:WI rats exhibited a higher level of response against the serotypes 2 and 3. The immunogenic potency units of a national reference vaccine determined using the Slc:Wistar rats were reproduced on tests using the Crlj:WI rats. These results indicate that a titer of the neutralizing antibody obtained in response to a given dose of sIPV cannot be directly compared between these two rat strains, but that, more importantly, the potency units are almost equivalent for the two rat strains. Copyright © 2018 International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  1. Sporadic isolation of sabin-like polioviruses and high-level detection of non-polio enteroviruses during sewage surveillance in seven Italian cities, after several years of inactivated poliovirus vaccination.

    Science.gov (United States)

    Battistone, A; Buttinelli, G; Fiore, S; Amato, C; Bonomo, P; Patti, A M; Vulcano, A; Barbi, M; Binda, S; Pellegrinelli, L; Tanzi, M L; Affanni, P; Castiglia, P; Germinario, C; Mercurio, P; Cicala, A; Triassi, M; Pennino, F; Fiore, L

    2014-08-01

    Sewage surveillance in seven Italian cities between 2005 and 2008, after the introduction of inactivated poliovirus vaccination (IPV) in 2002, showed rare polioviruses, none that were wild-type or circulating vaccine-derived poliovirus (cVDPV), and many other enteroviruses among 1,392 samples analyzed. Two of five polioviruses (PV) detected were Sabin-like PV2 and three PV3, based on enzyme-linked immunosorbent assay (ELISA) and PCR results. Neurovirulence-related mutations were found in the 5'noncoding region (5'NCR) of all strains and, for a PV2, also in VP1 region 143 (Ile>Thr). Intertypic recombination in the 3D region was detected in a second PV2 (Sabin 2/Sabin 1) and a PV3 (Sabin 3/Sabin 2). The low mutation rate in VP1 for all PVs suggests limited interhuman virus passages, consistent with efficient polio immunization in Italy. Nonetheless, these findings highlight the risk of wild or Sabin poliovirus reintroduction from abroad. Non-polio enteroviruses (NPEVs) were detected, 448 of which were coxsackievirus B (CVB) and 294 of which were echoviruses (Echo). Fifty-six NPEVs failing serological typing were characterized by sequencing the VP1 region (nucleotides [nt] 2628 to 2976). A total of 448 CVB and 294 Echo strains were identified; among those strains, CVB2, CVB5, and Echo 11 predominated. Environmental CVB5 and CVB2 strains from this study showed high sequence identity with GenBank global strains. The high similarity between environmental NPEVs and clinical strains from the same areas of Italy and the same periods indicates that environmental strains reflect the viruses circulating in the population and highlights the potential risk of inefficient wastewater treatments. This study confirmed that sewage surveillance can be more sensitive than acute flaccid paralysis (AFP) surveillance in monitoring silent poliovirus circulation in the population as well as the suitability of molecular approaches to enterovirus typing.

  2. Phase II and III Clinical Studies of Diphtheria-Tetanus-Acellular Pertussis Vaccine Containing Inactivated Polio Vaccine Derived from Sabin Strains (DTaP-sIPV).

    Science.gov (United States)

    Okada, Kenji; Miyazaki, Chiaki; Kino, Yoichiro; Ozaki, Takao; Hirose, Mizuo; Ueda, Kohji

    2013-07-15

    Phase II and III clinical studies were conducted to evaluate immunogenicity and safety of a novel DTaP-IPV vaccine consisting of Sabin inactivated poliovirus vaccine (sIPV) and diphtheria-tetanus-acellular pertussis vaccine (DTaP). A Phase II study was conducted in 104 healthy infants using Formulation H of the DTaP-sIPV vaccine containing high-dose sIPV (3, 100, and 100 D-antigen units for types 1, 2, and 3, respectively), and Formulations M and L, containing half and one-fourth of the sIPV in Formulation H, respectively. Each formulation was administered 3 times for primary immunization and once for booster immunization. A Phase III study was conducted in 342 healthy infants who received either Formulation M + oral polio vaccine (OPV) placebo or DTaP + OPV. The OPV or OPV placebo was orally administered twice between primary and booster immunizations. Formulation M was selected as the optimum dose. In the Phase III study, the seropositive rate was 100% for all Sabin strains after primary immunization, and the neutralizing antibody titer after booster immunization was higher than in the control group (DTaP + OPV). All adverse reactions were clinically acceptable. DTaP-sIPV was shown to be a safe and immunogenic vaccine. JapicCTI-121902 for Phase II study, JapicCTI-101075 for Phase III study (http://www.clinicaltrials.jp/user/cte_main.jsp).

  3. Connaissance indigène des procédés de production du beurre de Pentadesma butyracea Sabine au Bénin

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    Aïssi, MV.

    2015-01-01

    Full Text Available Indigenous Knowledge on Production Processes of Pentadesma butyracea Sabine Butter in Benin. Pentadesma butyracea Sabine is a tree that produces fruits containing oleaginous seeds from which butter, similar to shea butter, is extracted. This butter, so far insufficiently known, is obtained traditionally by a poorly documented process. Based on a technological investigation in the rural area and a factorial correspondences analysis (FCA, this study contributes to a better knowledge of the traditional technology of the P. butyracea butter production in Benin. P. butyracea butter is extracted by twelve main successive unit operations. The transformers involved in the butter production belong to eight different ethnic groups. Two types of thermal pretreatments, namely cooking with water and roasting in a traditional furnace are applied to P. butyracea seeds. The influence of the ethnic group was reported, especially on the type of the thermal pretreatment applied to the seeds as well as the various unit operations of transformation implemented from fruit picking up to obtaining butter. This better knowledge will allow improving the traditional processes of the P. butyracea butter production in rural environment.

  4. La capacidad prospectiva y de visualización del escáner láser 3D aplicado al plan de conservación preventiva del conjunto cerámico, piedra y hierro de Antoni Gaudí y Josep María Jujol en la catedral gótica de Mallorca

    Directory of Open Access Journals (Sweden)

    Juan Antonio Ruiz

    2012-05-01

    Full Text Available In this work it is presented the prospective and visualization efficiency of the 3D laser scanner as a tool applied to the elaboration of a preventive conservation plan of the ceramic done by Antoni Gaudí and Josep Maria Jujol in the gothic cathedral of Mallorca .The usage of this technique has enabled its investigation regarding digital information storage and metrology of the whole surface and plastic elements in it. This ways it is determined the creation of a multidisciplinary and interactive database with documental, technical and prescriptive content in order to compose the preventive conservation plan.

  5. Analyzed immunogenicity of fractional doses of Sabin-inactivated poliovirus vaccine (sIPV) with intradermal delivery in rats.

    Science.gov (United States)

    Ma, Lei; Cai, Wei; Sun, Mingbo; Cun, Yina; Zhou, Jian; Liu, Jing; Hu, Wenzhu; Zhang, Xinwen; Song, Shaohui; Jiang, Shude; Liao, Guoyang

    2016-12-01

    The live-attenuated oral polio vaccine (OPV) will be no longer used when wild poliovirus (WPV) eliminating in worldwide, according to GPEI (the Global Polio Eradication Initiative) Reports. It is planning to replace OPV by Sabin-based inactivated poliovirus vaccine (sIPV) in developing countries, with purpose of reducing of the economic burden and maintaining of the appropriate antibody levels in population. It studied serial fractional doses immunized by intradermal injection (ID) in rats, to reduce consume of antigen and financial burden, maintaining sufficient immunogenicity; Methods: Study groups were divided in 4 groups of dose gradient, which were one-tenth (1/10), one-fifth (1/5), one-third (1/3) and one-full dose (1/1), according to the volume of distribution taken from the same batch of vaccine (sIPV). Wistar rats were injected intradermally with the needle and syringe sing the mantoux technique taken once month for 3 times. It was used as positive control that intramuscular inoculation (IM) was injected with one-full dose (1/1) with same batch of sIPV. PBS was used as negative control. Blood samples were collected via tail vein. After 30 d with 3 round of immunization, it analyzed the changes of neutralization antibody titers in the each group by each immunization program end; Results: The results of seroconversion had positive correlation with different doses in ID groups. The higher concentration of D-antigen (D-Ag) could conduct higher seroconversion. Furthermore, different types of viruses had different seroconversion trend. It showed that the geometric mean titers (GMTs) of each fractional-dose ID groups increased by higher concentration of D-Ag, and it got significant lower than the full-dose IM group. At 90 th days of immunization, the GMTs for each poliovirus subtypes of fractional doses were almost higher than 1:8, implied that it could be meaning positive seroprotection titer for polio vaccine types, according to WHO suggestion; Conclusions

  6. Historical Channel Adjustment and Estimates of Selected Hydraulic Values in the Lower Sabine River and Lower Brazos River Basins, Texas and Louisiana

    Science.gov (United States)

    Heitmuller, Franklin T.; Greene, Lauren E.

    2009-01-01

    The U.S. Geological Survey, in cooperation with the Texas Water Development Board, evaluated historical channel adjustment and estimated selected hydraulic values at U.S. Geological Survey streamflow-gaging stations in the lower Sabine River Basin in Texas and Louisiana and lower Brazos River Basin in Texas to support geomorphic assessments of the Texas Instream Flow Program. Channel attributes including cross-section geometry, slope, and planform change were evaluated to learn how each river's morphology changed over the years in response to natural and anthropogenic disturbances. Historical and contemporary cross-sectional channel geometries at several gaging stations on each river were compared, planform changes were assessed, and hydraulic values were estimated including mean flow velocity, bed shear stress, Froude numbers, and hydraulic depth. The primary sources of historical channel morphology information were U.S. Geological Survey hard-copy discharge-measurement field notes. Additional analyses were done using computations of selected flow hydraulics, comparisons of historical and contemporary aerial photographs, comparisons of historical and contemporary ground photographs, evaluations of how frequently stage-discharge rating curves were updated, reviews of stage-discharge relations for field measurements, and considerations of bridge and reservoir construction activities. Based on historical cross sections at three gaging stations downstream from Toledo Bend Reservoir, the lower Sabine River is relatively stable, but is subject to substantial temporary scour-and-fill processes during floods. Exceptions to this characterization of relative stability include an episode of channel aggradation at the Sabine River near Bon Wier, Texas, during the 1930s, and about 2 to 3 feet of channel incision at the Sabine River near Burkeville, Texas, since the late 1950s. The Brazos River, at gaging stations downstream from Waco, Texas, has adjusted to a combination of

  7. Delineation of marsh types of the Texas coast from Corpus Christi Bay to the Sabine River in 2010

    Science.gov (United States)

    Enwright, Nicholas M.; Hartley, Stephen B.; Brasher, Michael G.; Visser, Jenneke M.; Mitchell, Michael K.; Ballard, Bart M.; Parr, Mark W.; Couvillion, Brady R.; Wilson, Barry C.

    2014-01-01

    Coastal zone managers and researchers often require detailed information regarding emergent marsh vegetation types for modeling habitat capacities and needs of marsh-reliant wildlife (such as waterfowl and alligator). Detailed information on the extent and distribution of marsh vegetation zones throughout the Texas coast has been historically unavailable. In response, the U.S. Geological Survey, in cooperation and collaboration with the U.S. Fish and Wildlife Service via the Gulf Coast Joint Venture, Texas A&M University-Kingsville, the University of Louisiana-Lafayette, and Ducks Unlimited, Inc., has produced a classification of marsh vegetation types along the middle and upper Texas coast from Corpus Christi Bay to the Sabine River. This study incorporates approximately 1,000 ground reference locations collected via helicopter surveys in coastal marsh areas and about 2,000 supplemental locations from fresh marsh, water, and “other” (that is, nonmarsh) areas. About two-thirds of these data were used for training, and about one-third were used for assessing accuracy. Decision-tree analyses using Rulequest See5 were used to classify emergent marsh vegetation types by using these data, multitemporal satellite-based multispectral imagery from 2009 to 2011, a bare-earth digital elevation model (DEM) based on airborne light detection and ranging (lidar), alternative contemporary land cover classifications, and other spatially explicit variables believed to be important for delineating the extent and distribution of marsh vegetation communities. Image objects were generated from segmentation of high-resolution airborne imagery acquired in 2010 and were used to refine the classification. The classification is dated 2010 because the year is both the midpoint of the multitemporal satellite-based imagery (2009–11) classified and the date of the high-resolution airborne imagery that was used to develop image objects. Overall accuracy corrected for bias (accuracy

  8. La chapelle de la résidence universitaire Jean-Zay à Antony (Hauts-de-Seine) par Eugène Beaudouin : matériau traditionnel de l’architecture religieuse et création contemporaine

    OpenAIRE

    Florence Margo-Schwoebel

    2009-01-01

    Après avoir mené à Antony la construction de la résidence universitaire Jean Zay en dix-huit mois (1954-1955), grâce à des procédés de construction industrialisés, Eugène Beaudouin compléta son projet d’une chapelle indépendante, réalisée selon des procédés traditionnels et consacrée en 1961. Dans cette chapelle Sainte-Croix, l’architecte renouait avec une certaine approche historiciste, sans pour autant rompre avec la création contemporaine. Son goût affirmé pour la prédominance du dessin s’...

  9. Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE Study

    Directory of Open Access Journals (Sweden)

    Peter Reichardt

    2012-01-01

    Full Text Available The aim of the study was to assess health-related quality of life (HRQoL among metastatic soft tissue (mSTS or bone sarcoma (mBS patients who had attained a favourable response to chemotherapy. We employed the EORTC QLQ-C30, the 3-item Cancer-Related Symptoms Questionnaire, and the EQ-5D instrument. HRQoL was evaluated overall and by health state in 120 mSTS/mBS patients enrolled in the SABINE study across nine countries in Europe and North America. Utility was estimated from responses to the EQ-5D instrument using UK population-based weights. The mean EQ-5D utility score was 0.69 for the pooled patient sample with little variation across health states. However, patients with progressive disease reported a clinically significant lower utility (0.56. Among disease symptoms, pain and respiratory symptoms are common. This study showed that mSTS/mBS is associated with reduced HRQoL and utility among patients with metastatic disease.

  10. Eficácia da vacina Sabin em crianças subnutridas da Amazônia The efficacy of oral polio vaccine in malnourished Amazonian children

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    Klaus E. Stewien

    1985-02-01

    Full Text Available A eficácia da vacina Sabin foi determinada em 106 crianças normais e subnutridas da Amazônia, após a administração de uma e duas doses de vacina oral (trivalente. Após a aplicação de uma dose de vacina, verificou-se que apenas 9% das crianças com subnutrição pregressa (crônica e 43% das crianças normais formaram anticorpos neutralizantes (protetores contra dois ou três tipos de poliovírus (p = 0,04. Após duas doses de vacina, os níveis de imunidade dos dois grupos de crianças estudadas acusaram, respectivamente, 32% e 75% (p = 0,001. Estes resultados mostram que a resposta imunitária à vacina Sabin foi sensivelmente inferior no grupo das crianças subnutridas, do que no das crianças normais. Em decorrência disto, será necessário administrar um número maior de doses de vacina oral àquelas crianças, a fim de que níveis satisfatórios de imunidade contra a poliomielite sejam atingidos em toda a população infantil.Various hypotheses have been proposed to explain the diminished efficacy of the oral polio vaccine in underdeveloped tropical regions. In this study, the influence of mild to moderate chronic malnutrition on the development of antibodies to the 3 types of polioviruses was investigated in Brazilian Amazonian children. Vaccines were administered to 106 normal and stunted children, between 5 to 14 months of age, who were not suffering from acute malnutrition (wasting, in poor peri-urban slum areas of Manaus (AM and São Luis (MA during the National Poliomyelitis Vaccination Campaigns of 1981 and 1982. Two weeks after vaccination, blood was collected by digital puncture and the prevalence of neutralizing antibodies for the 3 types of polioviruses was determined in serum at a dilution of 1:8. In children who had received one dose of the vaccine, 43% of normal children had antibodies to 2 or 3 types of polioviruses, against only 9% of stunted children (p = .04. In children who had received 2 doses of vaccine, 75

  11. Rezension zu: Sabine Hark, Paula-Irene Villa (Hg.: Anti-Genderismus. Sexualität und Geschlecht als Schauplätze aktueller politischer Auseinandersetzungen. Bielefeld: transcript Verlag 2015.

    Directory of Open Access Journals (Sweden)

    Christian Hammermann

    2017-05-01

    Full Text Available Der von Sabine Hark und Paula-Irene Villa herausgegebene Sammelband analysiert die öffentlichen Angriffe auf Gender Studies und Gender Mainstreaming, die unter dem Begriff Anti-Genderismus auftreten und verhandelt werden. Die einzelnen Beiträge untersuchen Themen und Methoden des anti-genderistischen Diskurses, seine Akteur_Innen und gesellschaftlichen Bedingung. Dabei entwerfen sie ein sehr kohärentes Porträt dieser Politiken, das allerdings von einer weiteren Untersuchung der gesellschaftlichen Bedingungen und intersektionalen Bezüge zu anderen Ressentiments profitieren würde.

  12. Concomitant administration of diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin strains (DTaP-sIPV) with pentavalent rotavirus vaccine in Japanese infants.

    Science.gov (United States)

    Tanaka, Yoshiyuki; Yokokawa, Ruriko; Rong, Han Shi; Kishino, Hiroyuki; Stek, Jon E; Nelson, Margaret; Lawrence, Jody

    2017-06-03

    Rotavirus is the leading cause of severe acute gastroenteritis in infants and young children. Most children are infected with rotavirus, and the health and economic burdens of rotavirus gastroenteritis on healthcare systems and families are considerable. In 2012 pentavalent rotavirus vaccine (RV5) and diphtheria, tetanus, acellular pertussis and inactivated poliovirus vaccine derived from Sabin strains (DTaP-sIPV) were licensed in Japan. We examined the immunogenicity and safety of DTaP-sIPV when administrated concomitantly with RV5 in Japanese infants. A total of 192 infants 6 to 11 weeks of age randomized to Group 1 (N = 96) received DTaP-sIPV and RV5 concomitantly, and Group 2 (N = 96) received DTaP-sIPV and RV5 separately. Antibody titer to diphtheria toxin, pertussis antigens (PT and FHA), tetanus toxin, and poliovirus type 1, 2, and 3 were measured at 4 to 6 weeks following 3-doses of DTaP-sIPV. Seroprotection rates for all components of DTaP-sIPV were 100% in both groups, and the geometric mean titers for DTaP-sIPV in Group 1 were comparable to Group 2. Incidence of systemic AEs (including diarrhea, vomiting, fever, and nasopharyngitis) were lower in Group 1 than in Group 2. All vaccine-related AEs were mild or moderate in intensity. There were no vaccine-related serious AEs, no deaths, and no cases of intussusception during the study. Concomitant administration of DTaP-sIPV and RV5 induced satisfactory immune responses to DTaP-sIPV and acceptable safety profile. The administration of DTaP-sIPV given concomitantly with RV5 is expected to facilitate compliance with the vaccination schedule and improve vaccine coverage in Japanese infants.

  13. Antibody responses of Macaca fascicularis against a new inactivated polio vaccine derived from Sabin strains (sIPV) in DTaP-sIPV vaccine.

    Science.gov (United States)

    Sato, Y; Shiosaki, K; Goto, Y; Sonoda, K; Kino, Y

    2013-05-01

    Antibody responses of Macaca fascicularis against a new tetravalent vaccine composed of diphtheria toxoid, tetanus toxoid, acellular pertussis antigens, and inactivated poliovirus derived from Sabin strains (sIPV) was investigated to predict an optimal dose of sIPV in a new tetravalent vaccine (DTaP-sIPV) prior to conducting a dose-defined clinical study. Monkeys were inoculated with DTaP-sIPVs containing three different antigen units of sIPVs: Vaccine A (types 1:2:3 = 3:100:100 DU), Vaccine B (types 1:2:3 = 1.5:50:50 DU), and Vaccine C (types 1:2:3 = 0.75:25:25 DU). There was no difference in the average titers of neutralizing antibody against the attenuated or virulent polioviruses between Vaccines A and B. The average neutralizing antibody titers of Vaccine C tended to be lower than those of Vaccines A and B. The sIPV antigens did not affect the anti-diphtheria or anti-tetanus antibody titers of DTaP-sIPV. Furthermore, the average neutralizing antibody titers of Vaccine A against the attenuated and virulent polioviruses were comparable between M. fascicularis and humans. These results suggest that M. fascicularis may be a useful animal model for predicting the antibody responses to sIPVs in humans, and that it may be likely to reduce the amount of sIPVs contained in DTaP-sIPVs, even for humans. Copyright © 2013 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

  14. La chapelle de la résidence universitaire Jean-Zay à Antony (Hauts-de-Seine par Eugène Beaudouin : matériau traditionnel de l’architecture religieuse et création contemporaine

    Directory of Open Access Journals (Sweden)

    Florence Margo-Schwoebel

    2009-11-01

    Full Text Available Après avoir mené à Antony la construction de la résidence universitaire Jean Zay en dix-huit mois (1954-1955, grâce à des procédés de construction industrialisés, Eugène Beaudouin compléta son projet d’une chapelle indépendante, réalisée selon des procédés traditionnels et consacrée en 1961. Dans cette chapelle Sainte-Croix, l’architecte renouait avec une certaine approche historiciste, sans pour autant rompre avec la création contemporaine. Son goût affirmé pour la prédominance du dessin s’y conjuguait à un jeu subtil sur la notion de « vérité du matériau », chère à l’architecture de la seconde moitié du XXe siècle. Mais le parti pris architectural semi-souterrain lui permettait surtout de développer un espace liturgique dramatisé, autour de la symbolique du baptême, en rapport direct avec les grands projets contemporains d’architecture religieuse.Using industrialised construction techniques, the architect Eugène Beaudouin was able to complete the building of the Jean Zay university residence, at Antony, in eighteen months, between 1954 and 1955. After completing this hall of residence, the architect then designed an independent chapel, built with traditional techniques and consecrated in 1961. In this Sainte-Croix chapel, Beaudouin renewed a certain historicist approach although he did not turn his back on contemporary creation. His pronounced taste for the predominance of design was associated with a subtle play on the notion of ‘the truth of the material’, one of the key architectural precepts of the second half of the 20th century. But the half-underground architecture also allowed him to create a dramatised liturgical space, around the symbolism of baptism and in relation to other contemporary projects in religious architecture.

  15. FERREIRA, Maria Alice Araújo; SOUZA, Germana Henriques Pereira de; GOROVITZ, Sabine (Org. Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. (Org.. Brasília: Editora da UnB, 2014. 219 p.

    Directory of Open Access Journals (Sweden)

    Marie Hélène C. Torres

    2014-12-01

    Full Text Available Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. Maria Alice Araújo Ferreira, Germana Henriques Pereira de Souza e Sabine Gorovitz (Org., Brasília: Editora da UnB, 2014. 219 p.

  16. Isolamento e identificação intratípica de cêpas de poliovirus associadas com a administração de vacina Sabin Isolation and intratypical identification on poliovirus strains following the administration of Sabin vaccine

    Directory of Open Access Journals (Sweden)

    José Alberto Neves Candeias

    1969-12-01

    Full Text Available Estudou-se a taxa de excreção de enterovírus em dois grupos de crianças de 1 a 4 anos de idade, que receberam várias doses de vacina Sabin. No primeiro grupo a colheita de fezes foi feita 60 dias após a administração da última dose de vacina e no segundo grupo, passados somente 15 dias. No primeiro grupo as porcentagens de isolamento de poliovírus e outros enterovírus foram, respectivamente, de 12,12% e 13,63%. já no segundo, estas porcentagens foram de 37,61% e 9,17%. Em ambos os grupos foram isolados os três tipos sorológicos de poliovírus. As taxas de isolamentos de poliovírus e outros enterovírus não se mostraram estatìsticamente diferentes, em ambos os grupos, quando relacionadas com o número de doses de vacina recebidas - duas ou menos doses e três ou mais doses. A identificação intratípica das cêpas de poliovirus isoladas foi feita pelos "marcadores" RCT40 e ds. Das 8 cêpas isoladas do primeiro grupo, 6 foram identificadas como intermediárias e 2 como cêpas naturais. Estas 2 cêpas foram isoladas das duas únicas crianças que não tinham sido vacinadas contra a poliomielite. Das 41 cêpas isoladas do segundo grupo, 8 foram caracterizadas como intermediárias e 33 como ceêpas tipicamente vacinais.The author studied the incidence of enterovirus excretion in 2 groups of children aged between 1 and 4 years, who had been given varying doses of Sabin polio vaccine. In the first group faeces were collected 60 days and in the second group 15 days after the last dose of vaccine had been given. In the first group 12,12% yielded poliovirus and 13,63% yielded "other enteroviruses"; in the second group the percentages were 37,61% and 9,17%. In both groups all three serological types of poliovirus were isolated. The previous vaccination status of the children in both groups, whether vaccinated with two or less or three or more doses, did not have a statistically significant effect on the subsequent virus isolations. The

  17. Género y participación de las mujeres en la gestión del agua en las subcuencas Río Sabinal y Cañón del Sumidero, Berriozábal, Chiapas

    Directory of Open Access Journals (Sweden)

    Verónica Gutiérrez Villalpando

    2013-01-01

    Full Text Available Este estudio presenta un enfoque de género sobre participación feme - nina en comités comunitarios de gestión del agua en las subcuencas Río Sabinal y Cañón del Sumidero en Berriozábal, Chiapas. Se encon - tró que la división entre lo público-masculino y lo privado-femenino, limita la participación femenina, siendo ésta posible sólo cuando las actividades en los comités de agua son consideradas de bajo prestigio entre los hombres. A pesar de ello, se plantea que la gestión del agua por las mujeres es una posibilidad para lograr una verdadera equidad de género, así como un desarrollo sustentable en las localidades.

  18. Sabine National Wildlife Refuge 1999

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Terracing uses existing bottom sediments to form terraces or ridges at marsh elevation and the intertidal zone is planted with marsh vegetation. This study examined...

  19. FERREIRA, Maria Alice Araújo; SOUZA, Germana Henriques Pereira de; GOROVITZ, Sabine (Org. Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. (Org.. Brasília: Editora da UnB, 2014. 219 p.

    Directory of Open Access Journals (Sweden)

    Marie Hélène C. Torres

    2014-12-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2014v2n34p294 Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. Maria Alice Araújo Ferreira, Germana Henriques Pereira de Souza e Sabine Gorovitz (Org., Brasília: Editora da UnB, 2014. 219 p.

  20. FERREIRA, Maria Alice Araújo; SOUZA, Germana Henriques Pereira de; GOROVITZ, Sabine (Org.) Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. (Org.). Brasília: Editora da UnB, 2014. 219 p.

    OpenAIRE

    Torres, Marie Hélène C.

    2014-01-01

    http://dx.doi.org/10.5007/2175-7968.2014v2n34p294 Ensaios de Teoria e Prática de Tradução. A tradução na sala de aula. Maria Alice Araújo Ferreira, Germana Henriques Pereira de Souza e Sabine Gorovitz (Org.), Brasília: Editora da UnB, 2014. 219 p.

  1. Sossius, Talbot and the Parthian Scene in Antony and Cleopatra ...

    African Journals Online (AJOL)

    Shakespeare in Southern Africa. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 22 (2010) >. Log in or Register to get access to full text downloads.

  2. Theatre Review: Antony and Cleopatra | Young | Shakespeare in ...

    African Journals Online (AJOL)

    Shakespeare in Southern Africa. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 22 (2010) >. Log in or Register to get access to full text downloads.

  3. Simon Hornblower, Antony Spawforth et al., The Oxford Classical Dictionary

    OpenAIRE

    Caracciolo Conicet, Tomás Fernández

    2013-01-01

    Les éditeurs de l’ocd déclarent – dès la troisième édition – que « as an authoritative one-volume guide to all aspects of the ancient world, ocd has no competitor in any language » (Preface to the third edition, p. ix), ainsi que « no other single-volume work of reference remotely approaches ocd in the sheer quality of factual detail contained » (ibid.). Qu’est-ce qu’une recension pourrait ajouter, si les éditeurs eux-mêmes sont aussi emphatiques dans les louanges de leur ouvrage ? La troisiè...

  4. Avaliação sorológica da vacina oral, tipo Sabin, contra a poliomielite em região semi-rural: I. Formação de anticorpos em vacinados

    Directory of Open Access Journals (Sweden)

    H. G. Schatzmayr

    1969-12-01

    Full Text Available Os autores descrevem, os resultados obtidos em um programa de avaliação sorológica da vacina oral, tipo Sabin, contra a poliomielite, em uma comunidade semi-rural, próxima a cidade do Rio de Janeiro. Em condições controladas 114 crianças, com idades entre 3 meses a 3 anos (Tabela 1 foram vacinadas, com vacinas trivalentes (500.000, 200.000, e 300.000 TCD50 por dose, dos tipos 1, 2 e 3 respectivamente, usando-se três doses, com intervalos de 8 semanas entre as doses. Amostras de sangue foram coletadas por punção venosa ou discos de papel de filtro, juntamente com a 1.ª e a 3.ª dose de vacina e 9 semanas após esta última dose de vacina. As taxas de conversão alcançaram (diluição de sôro 1/8 82,7%, 98,5% e 75,4% para os tipos 1, 2 e 3 respectivamente, após três doses de vacina (Tabela 2. A distribuição de idade de indivíduos sem anticorpos após a vacinação (Tabela 3 mostra o grupo etário de 1 a 2 anos como o que apresenta a mais baixa taxa de conversão. Os autores acentuam que as condições de vida da população estudada correspondem àquelas de grandes partes da população brasileira, nas áreas rurais do país; e uma avaliação semelhante da vacina em áreas urbanas, seria desejável. Os autores sugerem ainda o aumento da quantidade de vírus do tipo 1 na vacina como medida provàvelmente eficaz na melhora das taxas de conversão em populações como a estudada. Estudos quantitativos sôbre anticorpos para Enterovírus, presentes na população estudada, estão sendo realizados e serão pròximamente apresentados.

  5. 75 FR 65232 - Security Zones; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX

    Science.gov (United States)

    2010-10-22

    ... Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and does not create an environmental risk to health or risk to safety that may disproportionately affect children... for which the Captain of the Port, Port Arthur deems enhanced security measures necessary. In addition...

  6. 75 FR 29695 - Security Zones; Sabine Bank Channel, Sabine Pass Channel and Sabine-Neches Waterway, TX

    Science.gov (United States)

    2010-05-27

    ... rule under Executive Order 13045, Protection of Children from Environmental Health Risks and Safety Risks. This rule is not an economically significant rule and would not create an environmental risk to... proposes to establish moving security zones for certain vessels for which the Captain of the Port, Port...

  7. 2006-IJBCS-Article-Doamba W Sabine

    African Journals Online (AJOL)

    hp

    traitements (Combustible réduit correspondant à la parcelle dont la quantité de combustible a été réduite de moitié ... l'impact du feu sur la végétation (Tracy et ...... Fuel, Weather and Fire Behaviour. .... A Language and Environment for.

  8. Imunidade relativa à poliomielite em crianças de zero a dez anos, após o "Quarto Dia Nacional de Vacinação Contra a Poliomielite" com a vacinação oral trivalente, tipo Sabin, em área da Região da Grande São Paulo, SP (Brasil, 1982 Relative immunity to poliomyelitis in children up to ten years of age, after the "4th National Antipoliomyelitis Vaccination Day" with trivalent oral Sabin vaccine, in Greater S. Paulo (Brazil, 1982

    Directory of Open Access Journals (Sweden)

    Victório Barbosa

    1984-02-01

    Full Text Available Efetuou-se um levantamento soro-epidemiológico, abrangendo 898 crianças, para a verificação da imunidade aos poliovírus 1, 2 e 3 por meio da determinação dos títulos de anticorpos neutralizantes. De 522 crianças, ou seja, de 58,1% da população estudada, foi possível a obtenção de informações referentes à situação vacinal a partir de anotações existentes nas próprias Cadernetas de Vacinação. Neste último sub-grupo foi estudado o estado imunitário em relação ao número de doses de vacina oral tipo Sabin recebidas. Os resultados mostraram alta proporção de imunes para os três tipos de poliovírus entre as crianças estudadas, porém também revelaram a existência de lacuna imunitária nos menores de um ano, especialmente no primeiro semestre de vida. Não foram observadas diferenças importantes na proporção de imunes segundo o sorotipo considerado. Salientou-se a necessidade de um alerta constante e permanente em relação à ocorrência de possíveis surtos epidêmicos em segmentos mais vulneráveis da população, particularmente entre crianças menores de 1 ano.An epidemiological analysis was carried out on 898 children, in order to study the immune response to polioviruses 1, 2 and 3 by means of the measurement of neutralising antibodies. Information was obtained from 522 (58.1% of the children with regard to their vaccinal position by examination of the observations recorded on the individual vaccination certificates. In this subgroup the immune status in relation to number of Sabin type oral vaccine doses was analysed. The analysis demonstrated a high proportion of protected children for three types of polivirus, but also an immune response failure among the children of less than one year old, mainly during the first semester after birth. There were no relevant differences in relation to the proportion of protected individuals according to the considered serotype. The need for persistent and continuous

  9. Pseudocapillaria (Ichthyocapillaria maricaensis n. sp. (Nematoda, Capillariidae and remarks on the helminthological fauna of Liolaemus lutzae Mertens, 1938 (Lacertilia, Iguanidae

    Directory of Open Access Journals (Sweden)

    H. de Oliveira Rodrigues

    1992-06-01

    Full Text Available Pseudocapillaria (Ichthyicapillaria maricaensis n. sp. is described from the small intestine of the lizard, Liolaemus lutzae Meterns, 1938, collected in the State of Rio de Janeiro Brazil. The author compares the new species with Capillaria crotaliRudolphi, 1819 Travassos, 1915, Capillaria freitaslenti Araujo & Gandra, 1941, Pseudocapillaria (Pseudocapillaria amarali (Freitas & Lent, 1934 Moravec, 1952, Pseudocapillaria (Pseudocapillaria cezarpintoi (Freitas & Lent, 1934Moravec, 1952 and Pseudocapillaria (Ichthyocapillaria murinae (travassos, 1914 Moravec, 1952 previously reported from lizards in Brazil. The nematode Thelandros sceleratus Travassos, 1923 and the trematode paradistomum parvissimum (Travassos, 1918 Travassos, 1919 are for the first time reported from this same host.

  10. Staff members with 25 years' service at CERN in 2012

    CERN Multimedia

    HR Department

    2012-01-01

    The 27 staff members who have spent 25 years within CERN in 2012 were invited by the Director-General to a reception in their honour on 2 November.   BARRIN Laurence  -  PH BILLEN Ronald  -  BE BOUCHÉ Jean-Marc  -  HR BURKHARDT Helmut  -  BE CARLIER Etienne  -  TE CASS Antony  -  IT CHAN KWOK CHEON Anne Belinda  -  IT CHARRUE Pierre  -  BE COLLIER Paul  -  BE CUENCA PEREZ Antonio  -  GS DE JONGHE Jurgen  -  GS DEFERT Philippe  -  IT ELSENER Konrad  -  PH FROIDEVAUX Daniel  -  PH GRIGGS Christopher  -  PH MATHEYS Jean-Pol  -  HR MEIJERS Franciscus  -  PH MERTENS Volker  -  TE METRAL Gabriel  -  BE NECCA Rene  -  EN PACE Alberto&...

  11. Pastoral counselling of persons with homosexual tendencies in a heterosexual marriage / by Louis Antonie Gerber

    OpenAIRE

    Gerber, Louis Antonie

    2007-01-01

    The occurrence of marriages failing as a result of one member of the couple having a homosexual relationship has increased since the rewriting of the law on human rights. This resulted in a heightened need for pastoral care of members of the family that were affected by this tendency. Of cardinal importance to this study and in light of the constant debate about homosexuality in the church, a Scriptural foundation is found in the handling in cases of marriage breaking up as a resu...

  12. [History and reception of the translations of Plato's Dialogues by Antoni Bronikowski].

    Science.gov (United States)

    Mróz, Tomasz

    2014-01-01

    The article presents the history of translations of Plato's dialogues as made by A. Bronikowski (1817-1884), their assessment formulated by the contemporary for the translator recipients and today's opinions on them. Bronikowski began his translation work on the legacy of Plato in the '50s of the 19th century and carried them out systematically, despite the many adversities, until his death. The article presents the most important criticisms of the reviewers of Bronikowski's translations, which focused on the flaws of his style. The critics pointed out numerous shortcomings, archaisms, which hindered and prevented smooth reading of the text by readers unfamiliar with the language of the original. Most of the criticisms came from the Warsaw environment, especially from K. Kozłowski, the son of the first Polish translator of Plato, FA. Kozłowski. Among the defenders of Bronikowski there were K. Libelt and J.I. Kraszewski. They raised the subject of difficulty which the translator had to deal with and the lack of literary taste of the audience. It seems that both parties were partially right. Bronikowski's text was indeed not suitable for smooth reading in many places, however, it could serve as a useful tool for students who acquainted themselves with the Greek originals of the dialogues.

  13. Droplet dispersion angle measurements on a Pease-Antony Venturi scrubber

    OpenAIRE

    Puentes,N. A. G.; Guerra,V. G.; Coury,J. R.; Gonçalves,J. A. S.

    2012-01-01

    A Pease-Anthony Venturi scrubber is a gas cleaning device that uses liquid, injected in the equipment as jets, to remove contaminants from the gas. The liquid jet is atomized into droplets, which are dispersed throughout the equipment due to the turbulence. The performance of the scrubber is affected by the spatial distribution of the droplets. Although CFD models have been used to predict the droplet dispersion, these models are expensive. Alternatively, the concept of "jet spreading angle" ...

  14. Droplet dispersion angle measurements on a Pease-Antony Venturi scrubber

    Directory of Open Access Journals (Sweden)

    N. A. G. Puentes

    2012-03-01

    Full Text Available A Pease-Anthony Venturi scrubber is a gas cleaning device that uses liquid, injected in the equipment as jets, to remove contaminants from the gas. The liquid jet is atomized into droplets, which are dispersed throughout the equipment due to the turbulence. The performance of the scrubber is affected by the spatial distribution of the droplets. Although CFD models have been used to predict the droplet dispersion, these models are expensive. Alternatively, the concept of "jet spreading angle" could be used as a simple and quick way to estimate droplet dispersion. The purpose of this paper is to measure the spreading angle of jets transversally injected into the throat of a Venturi scrubber and correlate it with both gas and jet velocities. The throat gas velocities varied between 59 and 74 m/s and the jet velocity between 3.18 and 19.1 m/s. The angles were measured through image analysis, obtained with high velocity photography. The spreading angle was found to be strongly dependent on jet velocity.

  15. Acoustic neuroma: predominance of Antoni type B cells in tumors of patients with vestibular paresis.

    NARCIS (Netherlands)

    Stipkovits, E.M.; Graamans, K.; Jansen, G.H.; Velthof, M.A.

    2001-01-01

    OBJECTIVE: This study aimed to investigate whether in patients with acoustic neuroma (AN), the presence or absence of vestibular symptoms is related to the histologic characteristics of the tumor. STUDY DESIGN: The study design was a retrospective clinical study. SETTING: The study was conducted at

  16. Concrete in the education of the architect Antoni Gaudí

    OpenAIRE

    Saura Carulla, Magdalena

    2015-01-01

    A collaborative dimension on concrete business accounts for the education of a Gaudí's modernismo modernized. Eusebi Güell (1853–1926) met the young architect in the International Paris Exhibition of 1879. At the same period of time, Güell was transferring technology from the U.S. of America to Barcelona with other industrialists such as J. Francisco de Navarro (1823–1909). Their joint Portland cement industry played a major role in the evolution of concrete construction in Spain and in the w...

  17. see Gupta VK 433 Andreev V see Porcellato AM 963 Antony J see ...

    Indian Academy of Sciences (India)

    Cryogenic, superconducting and rf results of the SRFQ2 of PIAVE. 963. Prakash P N. Superconducting linear accelerator system for. NSC. 849 see Ghosh S. 881. Prakash S see Sharma Hitesh. 497. Prasad J see Chopra S. 753. Prasad Moonooku see Pande S A. 859. Prasad R L. CO2 laser photoacoustic spectra and vibra-.

  18. Verandering van geloofsvoorstelling : analyse van legitimaties door Antony Flew, Cees Dekker en Raymond Bradley

    NARCIS (Netherlands)

    Pronk, Michiel

    2016-01-01

    Revision of beliefs is a common practice. An opinion that once was considered right, is now considered wrong. The interest in this study is in the revision of religious beliefs. Research questions in this dissertation are: (1) How do people justify their revision of religious beliefs? (2) How did

  19. Antony Osler. 2008. "Stoep Zen – A Zen Life in South Africa ...

    African Journals Online (AJOL)

    The pale sun sets. The shadows creep across my shoes. Soon it will be time for meditation, Then a whiskey (104). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's ...

  20. Glutathione is a highly efficient thermostabilizer of poliovirus Sabin strains.

    Science.gov (United States)

    Abdelnabi, Rana; Delang, Leen; Neyts, Johan

    2017-03-07

    Glutathione (GSH) is the most abundant thiol peptide in animal cells and has a critical role in antioxidation. GSH was reported to be essential for stabilization of some enteroviruses, including poliovirus (PV), during viral morphogenesis. Here, we explored the potential use of GSH as a thermostabilizer of oral poliomyelitis vaccine (OPV) formulations. GSH significantly protected the three types of PV from heat-inactivation in a concentration-dependent manner. At a GSH concentration of 20mM, nearly complete protection was observed against heating temperatures up to 53°C for 2min.GSH also markedly protected PV1 from heat-inactivation and this up to 6 h at temperatures of 44°C and 46°C and 3 h at 48°C. The fact that GSH is naturally present at high concentration in the human body makes it an efficient candidate stabilizer for OPV formulations. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Carl L. Estes Lake. Sabine River, Texas. Draft Environmental Statement.

    Science.gov (United States)

    1975-10-01

    Didelphis marsupialis), raccoon (Procyon lotor), mink ( Mustela vison ), nutria, and various rodents. The variety of bird species is fairly large...has another bearing on the welfare of fish in that they contribute significantly to the cycles of nutrients and respiratory gases in the ecosystem. 2.39

  2. Sabine absorption coefficients to random incidence absorption coefficients

    DEFF Research Database (Denmark)

    Jeong, Cheol-Ho

    2014-01-01

    into random incidence absorption coefficients for porous absorbers are investigated. Two optimization-based conversion methods are suggested: the surface impedance estimation for locally reacting absorbers and the flow resistivity estimation for extendedly reacting absorbers. The suggested conversion methods...

  3. North Texas Sediment Budget: Sabine Pass to San Luis Pass

    Science.gov (United States)

    2006-09-01

    concrete units have been placed over sand-filled fabric tube . .......................................33 Figure 28. Sand-filled fabric tubes protecting...system UTM Zone 15, NAD 83 Longshore drift directions King (in preparation) Based on wave hindcast statistics and limited buoy data Rollover Pass...along with descriptions of the jetties and limited geographic coordinate data1 (Figure 18). The original velum or Mylar sheets from which the report

  4. 77 FR 277 - Sabine Pass Liquefaction, LLC and Sabine Pass LNG, L.P; Notice of Availability of the...

    Science.gov (United States)

    2012-01-04

    ... contains gas treatment facilities, six gas turbine-driven refrigerant compressors, waste heat recovery systems, induced draft air coolers, fire and gas detection and safety systems, control systems, and... compressors, potable water, service water, and demineralized water systems); and New and remodeled buildings...

  5. Shoreline Elevation Sabine Basin, Geographic NAD83, OSRADP/LOSCO (2008) [Shoreline_Elevation_Sabine_Basin_OSRADP_2008

    Data.gov (United States)

    Louisiana Geographic Information Center — These data consist of vector line segments tagged with elevation derived from the LOSCO/FEMA LIDAR five meter DEM data set for seven watershed basins in the...

  6. 77 FR 52711 - Sabine River Authority of Texas and Sabine River Authority, State of Louisiana; Notice of...

    Science.gov (United States)

    2012-08-30

    ..., containing two vertical Kaplan turbines with an authorized installed capacity of 81 megawatts (MW); (5) a 220... construct a 1.3-MW minimum flow turbine-generator at the project spillway. The offer of settlement involves...

  7. A potential recovery of a population of the sand lizard Liolaemus lutzae Mertens, 1938 in an area within its range: a lizard endemic and threatened with extinction

    Directory of Open Access Journals (Sweden)

    CFD. Rocha

    Full Text Available The endemic and threatened lizard Liolaemus lutzae has a relatively small geographic range restricted to only 200 km of along the coast of Rio de Janeiro State, Brazil, which are habitats under intensive anthropic disturbance. At the Barra da Tijuca beach, in Rio de Janeiro city an estimate of the population abundance made in 1991, compared to a previous estimate made in 1984, showed a considerable decrease (about 65%. Most of the decrease was attributed to anthropic disturbances that locally affected the beach vegetation, the species habitat. In this study we present estimates made in 2002 and in 2006 at the same area and compare them with the estimates of 1984 and 1991, using the same methodology in order to make comparable the data from different samplings years and to evaluate the present status of the local population. The estimated indexes of L. lutzae abundance in 2002 and in 2006 were higher than that of 1991. There was a significant increase in the mean number of recorded lizards in 2002 compared to 1991, but the mean number of lizards sighted in 2006 remained stable when compared with that of 2002. Our data based on the index of abundance recorded suggested that the number of L. lutzae at Barra da Tijuca beach recorded increased, which can be indicative of a potential recovery of the local population.

  8. Estado sistemático y distribución geográfica de Argenteohyla siemersi (Mertens, 1937 en la República Argentina (Anura: Hylidae

    Directory of Open Access Journals (Sweden)

    Williams, Jorge Daniel

    1994-01-01

    Full Text Available Argenteohyla siemersi pederseni n. subsp. is described from the province of Corrientes, Argentina. The new subspecies is differentiated from Argenteohyla siemersi siemersi by the coloration pattern and the presence of two longitudinal black lines in the dorsum. Comments on the habitat and biogeography are added.

  9. Potential distribution of the endangered endemic lizard Liolaemus lutzae Mertens, 1938 (Liolaemidae: are there other suitable areas for a geographically restricted species?

    Directory of Open Access Journals (Sweden)

    GR. Winck

    Full Text Available In this study we attempted to access further information on the geographical distribution of the endangered lizard Liolaemus lutzae, estimating its potential distribution through the maximum entropy algorithm. For this purpose, we related its points of occurrence with matrices of environmental variables. After examining the correlation between environmental matrices, we selected 10 for model construction. The main variables influencing the current geographic distribution of L. lutzae were the diurnal temperature range and altitude. The species endemism seemed to be a consequence of a reduction of the original distribution area. Alternatively, the resulting model may reflect the geographic distribution of an ancestral lineage, since the model selected areas of occurrence of the two other species of Liolaemus from Brazil (L. arambarensis and L. occipitalis, all living in sand dune habitats and having psamophilic habits. Due to the high loss rate of habitat occupied by the species, the conservation and recovery of the remaining areas affected by human actions is essential.

  10. Insights into chameleons of the genus Trioceros (Squamata: Chamaeleonidae) in Cameroon, with the resurrection of Chamaleon serratus Mertens, 1922

    Czech Academy of Sciences Publication Activity Database

    Barej, M. F.; Ineich, I.; Gvoždík, Václav; Lhermitte-Vallarino, N.; Gonwouo, N.L.; Le Breton, M.; Bott, U.; Schmitz, A.

    2010-01-01

    Roč. 57, č. 2 (2010), s. 211-229 ISSN 2190-7307 R&D Projects: GA MŠk LC06073 Institutional research plan: CEZ:AV0Z50450515 Keywords : Chameleon serratus * Cameroon * insights Subject RIV: EG - Zoology

  11. Uma Tradução Anotada de Antony and Cleopatra: Propósitos e Procedimentos

    Directory of Open Access Journals (Sweden)

    José Roberto O’Shea

    1996-01-01

    Full Text Available A PARTIR DO INÍCIO DESTE SÉCULO, estudiosos de Shakespeare passaram a demonstrar interesse pela recepção da obra do poeta e dramaturgo inglês "no exterior". Como seria de se esperar, o estudo da recepção da obra shakespeariana tem passado pelo estudo de sua tradução. No caso da dramaturgia, a partir da década de 1960, com o desenvolvimento dos estudos literários e dramáticos e, ainda, dos estudos da tradução, as traduções têm sido estudadas sob diversos métodos analíticos, a partir de diversas abordagens — textual, contextual, dramática, cultural, etc. —, servindo, freqüentemente, como suporte para validação desta ou daquela teoria. Contudo, apesar do muito que tem sido dito e escrito a respeito de Shakespeare em tradução, a importância que traduções de sua obra poética e dramática têm exercido na disseminação mundial de sua arte e mesmo no estabelecimento de sua posição central no cânone ocidental não têm recebido a devida ênfase. Na verdade, precisamos nos lembrar deque Shakespeare escreveu em um idioma, que, na Renascença, estava longe de ser hegemônico e que, portanto, precisaria ser traduzido.

  12. De cómo acabar la iglesia de la Colonia Güell obra de Antoni Gaudí

    Directory of Open Access Journals (Sweden)

    José Luis González

    2000-12-01

    Full Text Available La conservación de una obra inacabada de Gaudí esconde un complejo panorama de implicaciones históricas, psicológicas, estructurales y funcionales que se añaden al mito que rodea la obra del maestro catalán. El artículo profundiza en el concepto del templo, presenta unas primeras reflexiones y plantea un proyecto de intervención que renuncia en todo momento a la continuación y la recreación de la obra de Gaudí, sin eludir el difícil problema de la permanencia definitiva de la obra inacabada.

  13. 78 FR 73097 - Ocean Dumping; Sabine-Neches Waterway (SNWW) Ocean Dredged Material Disposal Site Designation

    Science.gov (United States)

    2013-12-05

    ...: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: The EPA today designates four new Ocean... suitable dredged material generated from new work (construction) and future maintenance dredging from the... dredged material generated from new work (construction) and future maintenance dredging along the SNWW...

  14. Sabine Beckmann: Geteilte Arbeit? Münster: Verlag Westfälisches Dampfboot 2008

    Directory of Open Access Journals (Sweden)

    Hildegard Theobald

    2009-07-01

    Full Text Available Im Zentrum des Buches steht die Frage der Relevanz wohlfahrtsstaatlicher Regulierungen für die geschlechtliche Verteilung familiärer Sorgearbeit. Konzeptionell verbindet die Autorin Ansätze aus der geschlechtssensiblen international vergleichenden Wohlfahrtsstaatsforschung mit Ansätzen zu Genderregimen. Empirisch untersucht sie fundiert in einer Quer- und Längsschnittstudie die Entwicklungen in Schweden, Frankreich und Deutschland in den letzten 50 Jahren in den Feldern der Politikentwicklung, der geschlechtlichen Verteilung privater Sorgearbeit und der geschlechterkulturellen Entwicklungen, insbesondere der Rolle von Vätern. Neben dem innovativen Ansatz liefert das Buch einen fundierten empirischen Überblick über die Veränderungsprozesse in den drei Vergleichsländern und liefert damit einen wertvollen Beitrag zur politischen Diskussion und zur wissenschaftlichen Weiterentwicklung.This book centers on the question as to the relevance of social welfare state regulation for the gendered distribution of family care work. The author conceptually binds the results of gender sensitive, international, and comparative research on social welfare states that find a way of approaching gender regimes. In her cross-sectional and longitudinal study she empirically examines the developments in Sweden, France, and Germany in the last 50 years. She focuses specifically on political developments, the gendered distribution of private care work, and gender-cultural developments, especially in terms of the role of fathers. The book takes an innovative approach and provides an empirically founded overview of the processes of change in the three comparative countries. It therefore provides a valuable contribution to the political discussion and to continuing scholarly development.

  15. Regulatory Aspects of Sabin Type 2 Withdrawal From Trivalent Oral Poliovirus Vaccine: Process and Lessons Learned.

    Science.gov (United States)

    Decina, Daniela; Fournier-Caruana, Jacqueline; Takane, Marina; Ostad Ali Dehaghi, Razieh; Sutter, Roland

    2017-07-01

    Withdrawal of type 2 oral poliovirus vaccine (OPV) in OPV-using countries required regulatory approval for use of inactivated poliovirus vaccine and bivalent OPV in routine immunization. Worldwide, a variety of mechanisms were used by member states, with some differences in approach observed between inactivated poliovirus vaccine and bivalent OPV. These included acceptance for use of World Health Organization (WHO) prequalified vaccines, registration and licensure pathways, participation in WHO-convened joint reviews of licensing dossiers, as well as pragmatic application of alternatively available mechanisms, when appropriate. Simple but effective tools were used to monitor progress and to record, authenticate, and share information. Essential to achievement of regulatory targets was ongoing communication with key stakeholders, including switch-country national regulatory authorities, vaccine manufacturers, partner organizations, and relevant units within WHO. Understanding of the regulatory environment gained through the OPV switch can be helpful in supporting further stages of the polio end game and other time-sensitive vaccine introduction programs. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

  16. Paralytic poliomyelitis associated with Sabin monovalent and bivalent oral polio vaccines in Hungary.

    Science.gov (United States)

    Estívariz, Concepción F; Molnár, Zsuzsanna; Venczel, Linda; Kapusinszky, Beatrix; Zingeser, James A; Lipskaya, Galina Y; Kew, Olen M; Berencsi, György; Csohán, Agnes

    2011-08-01

    Historical records of patients with vaccine-associated paralytic poliomyelitis (VAPP) in Hungary during 1961-1981 were reviewed to assess the risk of VAPP after oral polio vaccine (OPV) administration. A confirmed VAPP case was defined as a diagnosis of paralytic poliomyelitis and residual paralysis at 60 days in a patient with an epidemiologic link to the vaccine. Archived poliovirus isolates were retested using polymerase chain reaction and sequencing of the viral protein 1 capsid region. This review confirmed 46 of 47 cases previously reported as VAPP. Three cases originally linked to monovalent OPV (mOPV) 3 and one case linked to mOPV1 presented after administration of bivalent OPV 1 + 3 (bOPV). The adjusted VAPP risk per million doses administered was 0.18 for mOPV1 (2 cases/11.13 million doses), 2.96 for mOPV3 (32 cases/10.81 million doses), and 12.82 for bOPV (5 cases/390,000 doses). Absence of protection from immunization with inactivated poliovirus vaccine or exposure to OPV virus from routine immunization and recent injections could explain the higher relative risk of VAPP in Hungarian children. In polio-endemic areas in which mOPV3 and bOPV are needed to achieve eradication, the higher risk of VAPP would be offset by the high risk of paralysis due to wild poliovirus and higher per-dose efficacy of mOPV3 and bOPV compared with trivalent OPV.

  17. BIOACTIVE COMPOUNDS IN CONVENTIONAL AND NO ADDED SUGARS RED STRAWBERRY GUAVA (Psidium cattleianum Sabine JELLIES

    Directory of Open Access Journals (Sweden)

    GABRIELA NIEMEYER REISSIG

    Full Text Available ABSTRACT This study aimed to prepare jellies of conventional type of red strawberry guava (with added sucrose and no added sugar and evaluate the physical and chemical composition and content of bioactive compounds in them. Four jellies formulations were prepared: conventional with addition of sucrose (F1, aspartame (F2, saccharin and cyclamate (F3, acesulfame and sucralose (F4. Physicochemical analysis of pH were carried out, as well as analysis of titratable acidity, total soluble solids, ashes, proteins, lipids, moisture, carbohydrates, calories, lightness, color tone, total phenols, anthocyanins, carotenoids, ascorbic acid and antioxidant activity, by the capture of DPPH and ABTS radicals. Conventional and no added sugars jellies did not differ for total phenols, total anthocyanins and ascorbic acid. However, processing exerted significant influence (p=0.05 on total carotenoids and antioxidant activity. It is feasible to use red strawberry guava for the preparation of conventional and no added sugar jellies. The products, however, show a significant difference in carotenoids content, with the highest content of these and higher antioxidant activity in processed jellies without sugars addition.

  18. 78 FR 44934 - Sabine Pass Liquefaction, LLC; Application for Long-Term Authorization To Export Liquefied...

    Science.gov (United States)

    2013-07-25

    ...) previously approved on domestic natural gas supply and demand fundamentals. DOE will also consider any other... prohibited by U.S. law or policy. In the portion of SPL's Application subject to this Notice, SPL requests... treatment for trade in natural gas (non-FTA countries) with which trade is not prohibited by U.S. law or...

  19. 78 FR 44937 - Sabine Pass Liquefaction, LLC; Application for Long-Term Authorization To Export Liquefied...

    Science.gov (United States)

    2013-07-25

    ...) previously approved on domestic natural gas supply and demand fundamentals. DOE will also consider any other..., and with which trade in not prohibited by U.S. law or policy. In the portion of SPL's Application...) with which trade is not prohibited by U.S. law or policy. SPL requests that this authorization commence...

  20. Rehabilitation of Problem Soils Through Environmental Friendly Technologies-I: Effect of Sabins and Farmyard Manure

    International Nuclear Information System (INIS)

    Baig, Mirza B.; Ziaeldin, Mohammad S.; Mahler, Robert L.

    2004-01-01

    Environmental problem due to land degradation in the developing countries have been a matter of great cocern for the decades. The rehabilitation of problem land has been through many chemical means and engineering approaches, that have resulted in enhancing the gravity and the magnitude of problems. The present studies were undertaken to examine the role of environmental friendly practices to address the salinity issue. the effect of organic manuring (green manure and farmyard manure) or rice was investigated in a field study on a saline-sodic soil of the Saline Agriculture Research Station, Sadhuke, Pakistan. Sesbania was grown as a green manuring crop for two months and then incorporated into soil. farmyard manure (FYM) was applied at the rate of 0, 5, 10 and 20/ha before the sowing of Sesbania. Rice,Cv. Basmati 385 was used as the indicator/test crop. Results revealed that both paddy and straw yields were significantly improved by the application of sesbina and FYM. Green manure with sesbina improved the paddy and straw yields by 15.4% and 14.5% respectively. Productive tillers were also increased by the application of FYM but difference were not significant between 10 and 20ha/ of FYM application. FYM application also improved the paddy and straw yield significantly. The incrase in paddy yield due to application of 5, 10 and 20/ha of FYM were 6.8%, 24.4% and 37.6% over control, respectively. Nitrogen and phosphprus utilizationn by rice were also significantly improved with the application of green manure. Nitrogen uptake by rice was incresed by 17.8% and that of phosphorus by 21.9% with the green manuring. Nitrogen uptake was significantlty increased by the application of different rates of FYM. Also phosphorus uptake was increased significantly with the application of FYM. (author)

  1. H08737: NOS Hydrographic Survey , Sabine Bank, Louisiana-Texas, 1963-09-30

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  2. H08767: NOS Hydrographic Survey , Sabine Bank, Louisiana-Texas, 1962-09-27

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  3. F00199: NOS Hydrographic Survey , Sabine Bank, Louisiana-Texas, 1964-10-06

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  4. 78 FR 38672 - Ocean Dumping; Sabine-Neches Waterway (SNWW) Ocean Dredged Material Disposal Site Designation

    Science.gov (United States)

    2013-06-27

    ... potential aquatic and non-aquatic (i.e., land-based) alternatives and the consequences of not designating a... uses of the ocean, that they would not be human pathogens, and would not be non-indigenous species. The... Department of Natural Resources (LDNR) and the Texas General Land Office (TGLO), the agencies implementing...

  5. "La meilleure chose qui me soit arrivée" / Toomas Hendrik Ilves ; interv. Sabine Verhest

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2009-01-01

    Eesti riigipea räägib eestlaste ootustest ja võimalustest Euroopa Liidus, eurole üleminekust, majanduskriisiga toimetulemisest, Euroopa Liidu laienemisest, kandidaatidest Euroopa Ülemkogu eesistuja kohale

  6. H08739: NOS Hydrographic Survey , Sabine Bank, Louisiana-Texas, 1963-09-13

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  7. H10572: NOS Hydrographic Survey , Cameron, Louisiana to Sabine, Texas, 1994-11-09

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  8. Sabates per a na Catherina : Esclaves monàstiques al Monestir de Sant Antoni i Santa Clara de Barcelona (1350-1495)

    OpenAIRE

    Turull Pibernat, Emi

    2015-01-01

    En el marc de la ciutat de Barcelona, els drets de la dona a la baixa edat mitjana minvaven i havien fet una involució afavorida per una creixent misogínia. Així mateix, la ciutat havia esdevingut un indret rellevant com a mercat d'esclaus i la propietat d'esclaus i esclaves s'estenia de manera natural per tots els estaments de la societat, sense que l'Església la deslegitimés. Veurem què significava ser esclava i comprovarem la seva presència a les institucions monàstiques femenines de Barce...

  9. Antony Flew Del ateísmo al teísmo por la razón científica

    Directory of Open Access Journals (Sweden)

    Javier Monserrat

    2015-01-01

    Full Text Available Nos hemos referido principalmente en los últimos números de Pensamiento a lo que se ha venido en llamar en la última década el Nuevo Ateísmo, representado por Richard Dawkins, Daniel Dennett, Sam Harris y Christopher Hitchens. Stephen Hawking no pertenece a este grupo, pero sus ideas han sido comentadas con frecuencia en relación a la cuestión de Dios. Por ello, hemos abordado también una discusión de su idea del universo y su referencia a Dios. El Nuevo Ateísmo da por supuesto que la ciencia moderna excluye taxativamente la existencia de Dios. Sin embargo, estos no son los únicos ateos. Tanto desde el campo de la ciencia (vg. Steven Weinberg, Carl Sagan, el mismo Roger Penrose, como igualmente desde el campo de la filosofía en los últimos siglos y en la actualidad, numerosos pensadores han llenado las filas del ateísmo. La filosofía clásica de la modernidad dogmática fue atea en gran parte; de ahí la dificultad, mantenida durante siglos, de que se entablase un diálogo entre el teísmo cristiano antiguo y aquel ateísmo dogmático de la modernidad.

  10. Poesia contemporània i pintura: Salvador Espriu i Miquel Martí i Pol en l'obra d'Antoni Miró

    Directory of Open Access Journals (Sweden)

    Carles Cortés

    2014-02-01

    el grau de concreció dels poemes i dels collages, de manera que també hi hem pogut establir diversos paral·lelismes discursius i expressius, com ara els referits al pas del temps, l’angoixa pel passat i l’esperança pel futur. La principal aportació de Miró al sistema conceptual dels dos poetes és, sens dubte, el tractament de l’erotisme del cos femení a l’hora d’abordar diverses reflexions existencials localitzables en els seus poemaris.

  11. Chemical and mineralogical analyses of Roman amphorae from Augustan period recovered at the production center of Sant Antoni de Calonge (Gerona, Spain)

    International Nuclear Information System (INIS)

    Vila Socias, L.; Prats Pico, N.; Buxeda Garrigos, J.

    2016-01-01

    Amphorae were the most popular transport vessels used to ship wine and other commodities in Antiquity. This paper reports the results of the analyses of 38 samples of several Roman amphorae types recovered at Calonge (Gerona, Spain). Chemical composition of individuals have been obtained by means of XRF. Equivalent firing temperatures have been estimated by XRD and further refiring experiments have been performed. The results suggest the existence of two different clay pastes among individuals analyzed, most of which were fired at the range 900-1000 degree centigrade. Moreover, it is argued that craftsmen did not follow highly standardized paste preparation process during the first activity period of the workshop. The results are discussed in terms of production technology and standardization. (Author)

  12. Chemical and mineralogical analyses of Roman amphorae from Augustan period recovered at the production center of Sant Antoni de Calonge (Gerona, Spain); Analisis quimico y mineralogico de un conjunto de anforas romanas de epoca augustea procedentes del centro productor de Sant Antoni de Calonge (Gerona)

    Energy Technology Data Exchange (ETDEWEB)

    Vila Socias, L.; Prats Pico, N.; Buxeda Garrigos, J.

    2016-05-01

    Amphorae were the most popular transport vessels used to ship wine and other commodities in Antiquity. This paper reports the results of the analyses of 38 samples of several Roman amphorae types recovered at Calonge (Gerona, Spain). Chemical composition of individuals have been obtained by means of XRF. Equivalent firing temperatures have been estimated by XRD and further refiring experiments have been performed. The results suggest the existence of two different clay pastes among individuals analyzed, most of which were fired at the range 900-1000 degree centigrade. Moreover, it is argued that craftsmen did not follow highly standardized paste preparation process during the first activity period of the workshop. The results are discussed in terms of production technology and standardization. (Author)

  13. Caracterização do suco de araçá vermelho (Psidium cattleianum Sabine extraído mecanicamente e tratado enzimaticamente = Characterization of red araçá juice (Psidium cattleianum Sabine mechanically extracted and enzymatically treated

    Directory of Open Access Journals (Sweden)

    Marli da Silva Santos

    2007-12-01

    Full Text Available A partir do fruto de araçá vermelho, elaboraram-se dois tipos de sucos, mediante processamento mecânico, em que se obteve o suco S-1 e após tratamento enzimático de S-1 obteve-se o suco S-2, os quais foram analisados e monitorados durante quatro meses. As amostras de suco foram avaliadas reologicamente e quanto à estabilidadepor análises físico-químicas e microbiológicas. A aceitabilidade dos sucos foi avaliada por meio de análise sensorial, utilizando escala hedônica. O suco S-2 apresentou um rendimento de 73%. O tratamento enzimático elevou o rendimento do suco e reduziu a viscosidade, além de preservar a composição química e aumentar a extração de compostosfenólicos, resultando em um produto final com aspectos sensoriais pronunciados. From the red araçá fruit two types of juice were elaborated: S-1, obtained by mechanical processing and S-2 obtained from theenzymatic treatment of S-1. The juices were analyzed and monitored for four months. The samples were evaluated rheologically and also for stability by, physiochemical and microbiologic analyses. The acceptability of the juices was evaluated by sensorial analysisusing hedonic scale. The juice S-2 presented a high yield of 73%. The enzymatic treatment raised juice yield and reduced viscosity. In addition it preserved the chemical composition and raised the extraction of phenolic compounds, resulting on a final product of remarkable sensorial aspects.

  14. Oblique Aerial Photography of the Arctic Coast of Alaska, Cape Sabine to Milne Point, July 16-19, 2009

    Science.gov (United States)

    Gibbs, Ann E.; Richmond, Bruce M.

    2010-01-01

    The Arctic Coastal Plain of northern Alaska, an area of strategic economic importance to the United States, is home to remote Native American communities and encompasses unique habitats of global significance. Coastal erosion along the Arctic coast is chronic and widespread; recent evidence suggests that erosion rates are among the highest in the world (as high as ~16 m/yr) and may be accelerating. Coastal erosion adversely impacts energy-related infrastructure, natural shoreline habitats, and Native American communities. Climate change is thought to be a key component of recent environmental changes in the Arctic. Reduced sea-ice cover in the Arctic Ocean is one of the probable mechanisms responsible for increasing coastal exposure to wave attack and the resulting increase in erosion. Extended periods of permafrost melting and associated decreases in bluff cohesion and stability are another possible source of the increase in erosion. Several studies of selected areas on the Alaska coast document past shoreline positions and coastal change, but none have examined the entire North coast systematically. Results from these studies indicate high rates of coastal retreat that vary spatially along the coast. To address the need for a comprehensive and regionally consistent evaluation of shoreline change along the North coast of Alaska, the U.S. Geological Survey (USGS), as part of their Coastal and Marine Geology Program's (CMGP) National Assessment of Shoreline Change Study, is evaluating shoreline change from Peard Bay to the United States/Canadian border, using historical maps and photography and a standardized methodology that is consistent with other shoreline-change studies along the Nation's coastlines (see, for example, http://coastal.er.usgs.gov/shoreline-change/, last accessed February 12, 2010). This is the second in a series of publications containing photographs collected during reconnaissance surveys conducted in support of the National Assessment of Shoreline Change Study. An accompanying ESRI ArcGIS shape file (and plaintext copy) indicates the position of the aircraft and time when each photograph was taken. The USGS-CMGP Field Activity ID for the survey is A-5-09-AK, and more information on the survey and how to view the photographs using Google Earth software is available online at http://walrus.wr.usgs.gov/infobank/a/a509ak/html/a-5-09-ak.photos.kmz (last accessed February 12, 2010). The initial report ?Oblique aerial photography of the Arctic coast of Alaska, Nulavik to Demarcation Point, August 7-10, 2006? is available online at http://pubs.usgs.gov/ds/436/, and the associated Google Earth .kmz file is available at http://walrus.wr.usgs.gov/infobank/a/a106ak/html/a-1-06-ak.photos.kmz (last accessed February 12, 2010).

  15. 6 R eprod u ced by Sabin et G atew ay und er licen ce gran ted by th ...

    African Journals Online (AJOL)

    Pseudoanodontia -:-J'his condition cOQld be partial or total and iJ; due to failure ... "The Hong Kong Dental Association and the Asian Pacific Dental Congress will host .... fulfilment of its aims and objectives and will work diligently with regard.

  16. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by th e ...

    African Journals Online (AJOL)

    dental practice, education, research, and management is caJledDental .... Informatics: • 'Computers; offering immediate access. ··1.0 .... the ability tar multiple users to work simultaneously, ... Previous version of the, WindO\\vs operating systems.

  17. F00245: NOS Hydrographic Survey , Calcasieu Pass and Sabine Bank, Louisiana and Heald Bank, Texas, 1983-05-06

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  18. F00243: NOS Hydrographic Survey , Calcasieu Pass and Sabine Bank, Louisiana and Heald Bank, Texas, 1983-05-05

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Oceanic and Atmospheric Administration (NOAA) has the statutory mandate to collect hydrographic data in support of nautical chart compilation for safe...

  19. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by th e ...

    African Journals Online (AJOL)

    The mandible has been shown to be valuable in age estimation esp.:.cially in males where rounding of the mandible is an adult sex linked male feature (Loth SR et al 1998). Simple observation of the mandibles show clear differences in size, the height and rounding of the ramus, sympheseal height and markings caused by.

  20. Stool screening of Syrian refugees and asylum seekers in Germany, 2013/2014: Identification of Sabin like polioviruses.

    Science.gov (United States)

    Böttcher, Sindy; Neubauer, Katrin; Baillot, Armin; Rieder, Gabriele; Adam, Maja; Diedrich, Sabine

    2015-10-01

    Germany is a partner of the Global Polio Eradication Initiative. Assurance of polio free status is based on enterovirus surveillance, which focuses on patients with signs of acute flaccid paralysis or aseptic meningitis/encephalitis, representing the key symptoms of poliovirus infection. In response to the wild poliovirus outbreak in Syria 2013 and high number of refugees coming from Syria to Germany, stool samples from 629 Syrian refugees/asylum seekers aged Syrian refugees and asylum seekers at that time. Copyright © 2015 Elsevier GmbH. All rights reserved.

  1. R eprod u ced by Sabin et G atew ay und er licen ce gran ted by th e ...

    African Journals Online (AJOL)

    Dr. EA Mugonzibwa, School of Dentistry, Muhimbili University CoIlege of Health Sciences,. P.O. Box 65014, Dar ... DMF-T in the permanent dentition was reported to be 0.48-0.67 .... Government primary health care policy, which an oral health ...

  2. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by th e ...

    African Journals Online (AJOL)

    However. you are allowed to market your services. Dentists all over Tanzania are ... In most target audiences we can further find subgroups, some of which are more important sources of patients than others. In this way we can usually fairly ...

  3. Modeling and verification of acoustic wave propagation in indoors using Sabine model in turbine hall of a gas power plant

    Directory of Open Access Journals (Sweden)

    H. Ekhlas

    2014-05-01

    .Conclusion: The presented model is easy and practical and allows managers to model scenarios of noise pollution reduction in indoor environments, before huge expenses of actual control measures. This method is faster comparing to numerical modeling methods. Furthermore, its accuracy is also acceptable.

  4. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by the ...

    African Journals Online (AJOL)

    Thus, it is advisable to contact the local authorities, with the help of a legal ... idea of later expansion, involving a larger unit with possibly several dentists ... improve my social skills so that I am more empathic with my patients. ... Access the media. Identity can ... Create practice brochures, business cards and stationery. Every.

  5. The occurrence of Colpomenia peregrina (Sauv.) Hamel in the Mediterranean (Phaeophyta, Scytosiphonales)

    NARCIS (Netherlands)

    Blackler, H.

    1967-01-01

    Until the beginning of this century Colpomenia sinuosa (Mert.) Roth was the only species of the genus known in European waters; it was first found by Mertens in 1806 off Cadiz. Mertens made drawings of it and sent them with his specimens to Roth who described it as Ulva sinuosa and published the

  6. Stemcell Information: SKIP000875 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available CR ... Jerome Mertens--Fred H. Gage Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for...tudies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal ...University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovati... Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Ji

  7. Diagnostiek en behandeling van 39 patiënten met halskliermetastasen van plaveiselcelcarcinoom van onbekende primaire origine, verwezen naar het Nederlands Kanker Instituut/Antoni van Leeuwenhoek Ziekenhuis, 1979/'98

    NARCIS (Netherlands)

    Klop, W. M.; Balm, A. J.; Keus, R. B.; Hilgers, F. J.; Tan, I. B.

    2000-01-01

    Evaluation of diagnostic procedures and treatment results in patients with lymph node metastases of squamous cell carcinoma in the head and neck region with an unknown primary. Retrospective, descriptive. In 1979-98, 39 patients (30 male, 9 female; mean age 59 years; range: 39-88) were treated for

  8. Een revolutie gaat aan gekijf ten onder : de Stijl en de "Russische kwestie", najaar 1919 : een briefwisseling tussen Theo van Doesburg, Chris Beekman, Robert van 't Hoff, J.J.P. Oud en Antony Kok, met inleiding en annotaties

    NARCIS (Netherlands)

    Tibbe, Lieske

    2006-01-01

    Correspondence (38 letters, annotated) between several artists of the avant-gardist 'De Stijl'-grouping concerning the 'Russian question' (i.e. the controverse on sending a request to Parliament for free postal communication with artists in the Soviet Union). In literature on 'De Stijl', the

  9. Pecat amagat és mitg perdonat.... La polèmica entre mossèn Gudiol i Antoni Bulbena arran de les edicions bibliòfiles de llibres eròtics

    Directory of Open Access Journals (Sweden)

    Albert Domènech

    2014-06-01

    Full Text Available El desembre de 1911 aparegué a la premsa local de Vic un article que va aixecar molta polseguera entre els bibliòfils de tot Catalunya. Un mossèn –historiador de l’art i gran moralistaacusava un conegut editor de llibres de bibliofília –sense dir-ne el nom-, d’editar llibres luxosos de contingut priàpic (pornogràfic. Aquest fet anecdòtic ens serveix per saber qui era l’editor esmentat, què hi havia de cert en l’»acusació» i com va encaixar el vituperat veure’s exposat a la vergonya pública. La correspondència creuada entre els dos protagonistes, exclusivament per mitjà d’un amic comú, ens facilita l’anàlisi de l’argumentari de l’un i de l’altre. Això ens permet copsar com s’entenia, des de la moral més conservadora a la d’un moderat lliurepensament, l’ampli arc que va de la literatura de temàtica amorosa a les obres clarament pornogràfiques. In December 1911 appeared in the local press in Vic (a town near Barcelona an article that raised an uproar in the bibliophile circles all over Catalonia. A priest (an Art historian and great moralist accused a well-known editor of fine books, without naming him, of editing luxury books of pornographic content. This anecdote serves us to find out who this editor was, how much truth there was in the «accusation» and how the censored editor took the fact of being exposed to public shame. The correspondence between the priest and the editor, facilitated by a common friend, helps us analyze the arguments of both parties. We can grasp how the vast frame that embraces love literature to clearly pornographic works was perceived, both from the most conservative moral to a moderate free-thinking perspective.

  10. Sabine Hess, Nikola Langreiter, Elisabeth Timm (Hg.: Intersektionalität revisited. Empirische, theoretische und methodische Erkundungen. Bielefeld: transcript Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Sahra Dornick

    2012-08-01

    Full Text Available Für eine kritische Diskussion der Genealogie und der Weiterentwicklung von Intersektionalität finden sich in diesem Tagungsband neben ethnografischen Studien methodologische und theoretische Reflexionen, in welchen diese sowohl im Hinblick auf ihre analytischen Ermöglichungen und spezifische Leistungsfähigkeit als auch in Bezugnahme auf ihre methodischen Grenzen und kontextuellen Unschärfen erörtert wird. Allerdings gelingt es den Herausgeberinnen über weite Strecken nicht, Orientierung angesichts der komplexen Diversität zu vermitteln, und sie versäumen es so, Intersektionalität im Kontext seiner theoretischen Grenzen fruchtbar zu machen.Geared towards a critical discussion of genealogy and the advancement of intersectionality, these conference proceedings offer both ethnographic studies and methodological and theoretical reflections, which discuss both its analytical enablements and specific potential and its methodological boundaries and contextual fuzziness. To a great extent however, the editors fail to convey orientation considering the complex diversity and they, therefore, miss making intersectionality fruitful within its theoretical boundaries.

  11. Influence of extraction solvents on antioxidant and antimicrobial activities of the pulp and seed of Anisophyllea laurina R. Br. ex Sabine fruits

    Directory of Open Access Journals (Sweden)

    Gbago Onivogui

    2016-01-01

    Conclusions: Our results therefore demonstrated that ethanol and methanol extractions were more efficient in extracting antioxidants and bioactive compound in pulp and seed. These results support that these plant extracts can be used for the treatment of bacterial infections.

  12. Comparison of culture, single and multiplex real-time PCR for detection of Sabin poliovirus shedding in recently vaccinated Indian children.

    Science.gov (United States)

    Giri, Sidhartha; Rajan, Anand K; Kumar, Nirmal; Dhanapal, Pavithra; Venkatesan, Jayalakshmi; Iturriza-Gomara, Miren; Taniuchi, Mami; John, Jacob; Abraham, Asha Mary; Kang, Gagandeep

    2017-08-01

    Although, culture is considered the gold standard for poliovirus detection from stool samples, real-time PCR has emerged as a faster and more sensitive alternative. Detection of poliovirus from the stool of recently vaccinated children by culture, single and multiplex real-time PCR was compared. Of the 80 samples tested, 55 (68.75%) were positive by culture compared to 61 (76.25%) and 60 (75%) samples by the single and one step multiplex real-time PCR assays respectively. Real-time PCR (singleplex and multiplex) is more sensitive than culture for poliovirus detection in stool, although the difference was not statistically significant. © 2017 Wiley Periodicals, Inc.

  13. Potential nutritional and antioxidant activity of various solvent extracts from leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used in folk medicine

    Directory of Open Access Journals (Sweden)

    Gbago Onivogui

    2017-07-01

    Full Text Available ABSTRACT Anisophyllea laurina is a plant that has been used in folk medicine to treat malaria, dysentery, diabetes, toothache and various skin diseases. Leaves extract had protein content of 9.68% and a high calcium content of 25084.317 mg/100 g while stem bark extract was found to contain greater amounts of calcium (8560.96 mg/100 g, potassium (7649.47 mg/100 g, magnesium (1462.49 mg/100 g and iron (973.33 mg/100 g. Palmitic acid, linolenic acid, linoleic acid and oleic acid were the most abundant fatty acids in leaves and stem bark extracts. Furthermore, total phenolic (2382.39 mg GAE /100 g and total flavonoid (385.79 mg QE/100 g contents were abundant in stem bark while leaves extract was rich in total tannin content (3466.63 mg CE/100 g. However, both leaves and stem bark contained great amounts of vitamins and amino acids were a good source of antioxidant activities. For the individual polyphenol, stenophyllanin A (45.87 mg/g, casuarinin (24.55 mg/g and digalloyl-HHDP-glucopyranose isomer (15.63 mg/g were found to be the major compounds from the leaves whereas procyanidin tetramer (14.89 mg/g, (--Epicatechin (12.18 mg/g and procyanidin trimer (11.25 mg/g were the most predominant compounds from the stem bark. Additionally, the results revealed a significant and strong correlation between phenolic compounds and antioxidant activities.

  14. Review: Thomas S. Eberle, Sabine Hoidn & Katarina Sikavica (Eds. (2007. Fokus Organisation. Sozialwissenschaftliche Perspektiven und Analysen [Focus Organization: Social Scientific Perspectives and Analyses

    Directory of Open Access Journals (Sweden)

    Jo Reichertz

    2008-11-01

    Full Text Available This transdisciplinary anthology was published on the occasion of the 65th birthday of Emil WALTER-BUSCH, an organization scientist from St. Gallen, Switzerland. Alongside discussions of current theories about the character of organizations, the collection introduces and evaluates international management research as well as approaches to organizational change. All the articles are embedded in a reflexive approach to the production of social-scientific knowledge. This anthology, as interesting for organization researchers as for sociologists of knowledge and science, is particularly successful in not only taking up and developing the thoughts of Emil WALTER-BUSCH but also in capturing the spirit of his scientific work. URN: urn:nbn:de:0114-fqs0901219

  15. Lavorel Sabine, Les Constitutions arabes et l’islam. Les enjeux du pluralisme juridique, Presses de l’Université du Québec, 2005, 202 p.

    Directory of Open Access Journals (Sweden)

    Bernard Botiveau

    2008-07-01

    Full Text Available Dans les études juridiques sur les sociétés arabes actuelles, le droit constitutionnel reste un terrain à explorer. Quelques ouvrages sont parus récemment, tandis que des articles monographiques, pays par pays, faisaient régulièrement état des transformations normatives intervenues dans ce domaine. La réactivation de la justice constitutionnelle dans certains pays arabes a encouragé le renouveau de ce domaine de recherche dont l’accès limité tient aussi dans une certaine mesure à la difficult...

  16. Reptilia: Gekkonidae

    African Journals Online (AJOL)

    1997-03-13

    Mar 13, 1997 ... Fitzsimons 1935; Mertens 1946; Loveridge 1947; Brain. 1962; Oiess ..... longitudinal invagination, in which the left side of the trachea .... slightly to the right of the body long axis. .... motor control of central pattern generators.

  17. 16 July 2014 - Professor P. Strohschneider

    CERN Multimedia

    Gadmer, Jean-Claude

    2014-01-01

    President German Research Foundation Prof. P. Strohschneider visiting the LHC tunnel at Point 1 with Technology Deputy Department Head, V. Mertens and signing the Guest Book with the Director-General R. Heuer.

  18. In vitro gas production of wheat grain flour coated with different fat ...

    African Journals Online (AJOL)

    Jane

    2011-07-27

    Jul 27, 2011 ... restrict microbial digestion of structural polysaccharides. (Mertens and Loften, 1980; ... potential to reduce the extent of CH4 and CO2 production by manipulating animal ..... Methane Emissions from cattle. J. Anim. Sci. 73(8): ...

  19. Generation of Strategies for Environmental Deception in Two-Player Normal-Form Games

    Science.gov (United States)

    2015-06-18

    found in the literature is pre- sented by Kohlberg and Mertens [23]. A stable equilibrium by their definition is an equi- librium in an extensive-form...the equilibrium in this state provides them with an increased payoff. While interesting, Kohlberg and Mertens’ defi- 13 nition of equilibrium...stability used by Kohlberg and Mertens. Arsham’s work focuses on determining the amount by which a mixed-strategy Nash equilibrium’s payoff values can

  20. Stemcell Information: SKIP000872 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ... Jerome Mertens--Fred H. Gage Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Lang...s, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal Unive...rsity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Ce...ogical Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu

  1. Stemcell Information: SKIP000873 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ing, RT-PCR Yes qRT-PCR ... Yes ... Yes RT-PCR ... Jerome Mertens--Fred H. Gage Jerome Mertens--Fred H. Gage Jiangsu Collabor...iversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation...ry of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jian...gsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborati

  2. Opositsioon jääb endale kindlaks / Ulis Guth

    Index Scriptorium Estoniae

    Guth, Ulis, 1964-

    2003-01-01

    Võru linnavolikogus opositsiooni kuuluvate Keskerakonna ja Rahvaliidu saadikute protestist Andres Visnapuu valimise vastu linnavolikogu esimeheks. Keskerakondlasest volikogu liikme Tõnu Antoni arvamusest

  3. Composição química e respiração de crescimento em frutos de Psidium cattleyanum sabine durante o ciclo de desenvolvimento Chemical composition and growth respiration in Psidium cattleyanum sabine fruits during the development cycle

    Directory of Open Access Journals (Sweden)

    Adriana Silva Galho

    2007-04-01

    Full Text Available O experimento foi conduzido em condições de campo, sendo os frutos colhidos em araçazeiros de seis anos, crescidos no pomar da EMBRAPA- Clima Temperado. O objetivo foi determinar a composição química, a eficiência de conversão da glicose em novos compostos e a estimativa da respiração de crescimento de araçá ao longo da ontogenia do fruto. Os teores de macronutrientes decresceram ao longo do desenvolvimento do fruto. Os conteúdos de amido, carboidratos solúveis totais, açúcares redutores, lipídeos e ácidos orgânicos aumentaram, enquanto os teores de proteína e os componentes da parede celular diminuíram com a idade do fruto de araçá, principalmente na fase de maturação. Os carboidratos foram os maiores componentes orgânicos, fazendo com que o custo da respiração do fruto fosse baixo. O araçá foi eficiente na conversão de glicose em outros compostos orgânicos. O coeficiente de respiração de crescimento decresceu com a idade do fruto. A taxa de respiração de crescimento incrementou até a metade do período de crescimento acelerado do fruto.The experiment was carried out under field conditions, where the fruits were harvest in Brazilian guava trees with six years old, growing on orchard of EMBRAPA- Temperate weather. The aim of the research was to determine the chemical composition, the efficiency of glucose conversion in new compounds and growth respiration estimate of the fruits during its ontogeny. The macronutrients content decreased with fruit development cycle. The contents of starch, total soluble sugars, reduced sugars, lipids and organic acids augmented as the fruits aged, while the protein contents and the components of cell wall decreased during fruit ontogeny, with strong accumulation during ripening. The carbohydrates were the major organic compounds, determining low cost of fruit respiration. The Brazilian guava showed to be an efficient fruit on glucose conversion in other organic compounds. The respiratory coefficient decreased as the fruit aged. The growth respiration rate increased until the middle of accelerate growth phase of the fruit.

  4. Nous horitzons. La impugnació de la Sentència: vies, òrgans i procediments - Nuevos horizontes. La impugnación de la Sentencia: vías, órganos y procedimientos

    Directory of Open Access Journals (Sweden)

    Argelia Queralt

    2010-07-01

    Full Text Available La impugnació de la Sentència: possibilitats d’accés al Tribunal Europeu de Drets Humans (469-472Antoni Bayona RocamoraLa impugnación de la Sentencia: posibilidades de acceso al Tribunal Europeo de Derechos Humanos (475-478Antoni Bayona Rocamora

  5. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. ANTONY BENEDICT. Articles written in Sadhana. Volume 42 Issue 6 June 2017 pp 817-826. Deterministic oscillatory search: a new meta-heuristic optimization algorithm · N ARCHANA R VIDHYAPRIYA ANTONY BENEDICT KARTHIK CHANDRAN · More Details Abstract Fulltext PDF. The paper ...

  6. Die Evagriusübersetzung der Vita Antonii : Rezeption - Überlieferung - Edition : Unter besonderer Berücksichtigung der Vitas Patrum-Tradition

    NARCIS (Netherlands)

    Bertrand, P.H.E.

    2006-01-01

    The Life of Antony, translated by Evagrius of Antioch: Reception, Manuscript Tradition, Edition. With special emphasis on Vitas Patrum Tradition The Life of Antony is the first and one of the most famous saints’ lives that has ever been written. Shortly after the death of the desertfather

  7. Marsh terracing as a wetland restoration tool for creating fishery habitat in Calcasieu Lake/Sabine National Wildlife Refuge 1999-05-04 to 1999-09-20 (NCEI Accession 0156995)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data contains fish and invertebrate counts, weights, and measurements important to identify and describe the relationship between fishery productivity and the...

  8. Effet des prétraitements post-récolte des amandes de Pentadesma butyracea (Sabine sur la technologie d’extraction en milieu réel et la qualité du beurre

    Directory of Open Access Journals (Sweden)

    Aissi M. Vahid

    2011-11-01

    Full Text Available Pentadesma butter is still traditionally extracted starting from pretreated almonds by traditional techniques of heating. The aim of this work was to study the effect of the almonds post-harvest pretreatments on the physicochemical characteristics, the extraction yield and the quality of the Pentadesma butter. In addition, the effect of the various unit operations of the extraction technology on the quality of the extracted butter from pretreated almonds was studied. According to the same traditional process of extraction, two various butters of Pentadesma were extracted starting from almonds differing only by the post-harvest pretreatment applied (roasting or boiling. The color, the aspect and the breaking strength of the almonds were different. The butter extraction yield varied according to the pretreatment applied. The best yields (33.5 ± 4.1% were obtained from boiled almonds, but their transformation was more difficult than that of roasted. The analysis of the samples at different stages of the transformation allowed the appreciation of the effect of the almonds pretreatments on the acidity and the peroxide value variations at each unit operation of the butter extraction. The fatty acid composition and the tocopherol content of the two extracted butters varied with the almonds pretreatments. The roasted almonds provided a richer butter in stearic acid, a and d-tocopherols and less rich in oleic acid than that provided by the boiled almonds. The pretreatments allowed a total loss of the contained linolenic acid, b and dtocopherols in the butters and decreased the oleic acid and a- tocopherol contents. The physico-chemical characteristics of the Pentadesma butter varied according to the almonds pretreatments. Thus, it would be interesting to make a reasoned choice of the most suitable post-harvest pretreatment in order to obtain a butter with a good quality and an acceptable extraction yield.

  9. NAVFAC Ocean Thermal Energy Conversion (OTEC) Project; OTEC System Design Report

    Science.gov (United States)

    2010-11-16

    1-12. 37. Hoepner, Thomas, and Sabine Lattemann. “Chemical impacts from seawater desalination plants- a case study of the northern Red Sea... Jaime Echeverria. "Managing Water for People and Nature." Science 292 (2001): 1071-072. 46. Kalogirou, Soteris A. "Seawater desalination using...Lattemann Sabine . “Protecting the Marine Environment.” Seawater Desalination (2009): 273-299. 55. Lattemann, Sabine , and Thomas Hopner. "Environmental

  10. Beevor receives Estonian State decoration

    Index Scriptorium Estoniae

    2008-01-01

    Eesti suursaadik Suurbritannias Margus Laidre andis 2. juunil 2008 Londonis Suurbritannia ajaloolasele Antony James Beevorile üle talle president Toomas Hendrik Ilvese poolt annetatud Maarjamaa Risti III klassi teenetemärgi

  11. Tagasi tulevikku - keskaja naasmine / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2006-01-01

    Oxfordi St Antony kolledzhi lektori Jan Zielonka raamatu "Europe as Empire: the Nature of the Enlarged European Union" tutvustus, milles Euroopa Liitu käsitletakse uuskeskaegse impeeriumina. Kahe rahvusvahelise süsteemitüübi võrdlustabel

  12. 3 küsimust / interv. Elina Kononenko

    Index Scriptorium Estoniae

    2005-01-01

    Andres Kõivu (Isamaaliit), Ivari Padari (Sotsiaaldemokraatliku Erakond), Ülle Puustusmaa (Res Publica), Tõnu Antoni (Keskerakond), Ivi Eenmaa (Reformierakond), Toivo Teekeli (Kristliku Rahvapartei) ja Arno Silla (Rahvaliit) linnapeakandidaatide ja parteide esindajate vastused kohalike valimiste teemal

  13. Mõrvaprotsessi süüalune üritas uurijaid kohtusse anda / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2003-01-01

    Tartu endise abilinnapea Aleks Lenzneri poja Antoni tapmises kohtu alla antud Valeri Tsakker saatis kaitsepolitseisse avalduse, väites, et keskkriminaalpolitseinikud avaldasid talle psühholoogilist survet

  14. G model revisited: Seasonal changes in the kinetics of sulphate-reducing activity in the salterns of Ribander,Goa India

    Digital Repository Service at National Institute of Oceanography (India)

    Kerkar, S.; LokaBharathi, P.A.

    . Antonie van Leeuwenhoek. J. Microbial Serol 302:225- 238. Schubert C, Ferdelman TG, Strotmann B. 2000. Organic matter compostion and sulfate reducing rates in sediments off Chile. Organic Geochem 31: 351-361. Skyring GW. 1987. Sulfate reduction...

  15. Reptilia: Gekkonidae

    African Journals Online (AJOL)

    independenl dcrivations is uncertain, owing to poor resolu- tion in the phylogeny of gekkonine geckos. Most of the originations of regional integumentary loss have ..... Husbandry 8: 96-102. MERTENS, R. 1960. The world of amphibians and reptiles. McGraw-Hili, New York. MEYER, W., BARTELS, T. & NEURAND, K. 1989.

  16. Infection of cowpea protoplasts with sonchus yellow net virus and festuca leaf streak virus

    NARCIS (Netherlands)

    Beek, van N.A.M.

    1986-01-01

    The advantages of protoplast systems for plant virus research have been frequently reviewed (Zaitlin & Beachy, 1974; Takebe, 1975; Muhlbach, 1982; Sander & Mertens, 1984). Relatively little attention has been given to the limitations of such a system.

    Protoplasts do not

  17. The advertisement call, breeding biology, description ofthe tadpole ...

    African Journals Online (AJOL)

    1998-07-27

    Jul 27, 1998 ... and taxonomic status in the last century, It has been recog- nized either as a distinct species (Mertens ... in this extremely arid area. Data on breeding biology, vocalizations, and tadpole morphology of this toad ... A developmental series was preserved in 10% forma- lin (specimens not individually labeled): ...

  18. Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines

    NARCIS (Netherlands)

    van Maanen, J.M.S.; Welle, I.J.; Hageman, G.J.; Dallinga, J.W.; Mertens, P.L.; Kleinjans, J.C.S.

    1996-01-01

    Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines. van Maanen JM, Welle IJ, Hageman G, Dallinga JW, Mertens PL, Kleinjans JC. Department of Health Risk Analysis and Toxicology, University of Limburg,

  19. Use of the gamma function in equations which describe ruminal ...

    African Journals Online (AJOL)

    McDonald, 1981; Pond, Matis & Ellis, 1982; Mahlooji,. Ellis, Matis & Pond, 1984; Pienaar & Roux, 1984), which consist of a phase of increasing activity at the onset of both the outflow and fermentation processes. Mertens & Loften (1980) and McDonald (1981) accom- modated this deviation from first-order kinetics in their.

  20. Turby - sustainable urban wind power from the roof top

    NARCIS (Netherlands)

    Mertens, S.; Van Bussel, G.; Mols, B.

    2005-01-01

    If current trends are anything to go by, in future we will no longer produce all our electricity in large, central power stations. Small-scale local electricity generation will gain in importance. Sander Mertens, a post-doctoral student at TU Delft, developed the aerodynamic design of a wind turbine

  1. Political Communication Yearbook 1984.

    Science.gov (United States)

    Sanders, Keith R., Ed.; And Others

    Focusing on current scholarship in the evolving field of political communication, this publication is organized in three sections. Part 1, "Current Perspectives on the Spiral of Silence," features essays by Charles T. Salmon and F. Gerald Kline, Klaus Merten, Carroll J. Glynn and Jack M. McLeod, and a response by the theory's original…

  2. Some examples of tactical crime mapping in South Africa

    CSIR Research Space (South Africa)

    Cooper, Antony K

    2002-01-01

    Full Text Available SouthAfrica AntonyCooperandPeterSchmitz icomtek,CSIR,POBox395,Pretoria,0001,SouthAfrica Email:acooper@csir.co.za,pschmitz@csir.co.za 7January2002 1.Background TheCouncilforScientificandIndustrialResearch(CSIR)isoneofeightstatutoryScienceCouncils in...,especiallyPietByleveld,Andrew Davidson,BarkiesBarkhuizen,GerritRobbertse,KevinRossouwandChrisNaude. 6.References AntonyKCooper,PietByleveldandPeterMUSchmitz,“UsingGIStoreconcilecrimesceneswith thoseindicatedbyserialcriminals”,paperpresentedattheFifthInternationalCrime Mapping...

  3. Marketing Management

    DEFF Research Database (Denmark)

    Wilke, Ricky

    2012-01-01

    Book review of: Christian Homburg, Sabine Kuester, Harley Krohmer, Marketing Management – A Contemporary Perspective, McGraw-Hill Higher Education, 2009......Book review of: Christian Homburg, Sabine Kuester, Harley Krohmer, Marketing Management – A Contemporary Perspective, McGraw-Hill Higher Education, 2009...

  4. Correlation of mutations and recombination with growth kinetics of poliovirus vaccine strains.

    Science.gov (United States)

    Pliaka, V; Kyriakopoulou, Z; Tsakogiannis, D; Ruether, I G A; Gartzonika, C; Levidiotou-Stefanou, S; Krikelis, A; Markoulatos, P

    2010-12-01

    Attenuated strains of Sabin poliovirus vaccine replicate in the human gut and, in rare cases, may cause vaccine-associated paralytic poliomyelitis (VAPP). The genetic instability of Sabin strains constitutes one of the main causes of VAPP, a disease that is most frequently associated with type 3 and type 2 Sabin strains, and more rarely with type 1 Sabin strains. In the present study, the growth phenotype of eight oral poliovirus vaccine (OPV) isolates (two non-recombinants and six recombinants), as well as of Sabin vaccine strains, was evaluated using two different assays, the reproductive capacity at different temperatures (Rct) test and the one-step growth curve test in Hep-2 cells at two different temperatures (37°C and 40°C). The growth phenotype of isolates was correlated with genomic modifications in order to identify the determinants and mechanisms of reversion towards neurovirulence. All of the recombinant OPV isolates showed a thermoresistant phenotype in the Rct test. Moreover, both recombinant Sabin-3 isolates showed significantly higher viral yield than Sabin 3 vaccine strain at 37°C and 40°C in the one-step growth curve test. All of the OPV isolates displayed mutations at specific sites of the viral genome, which are associated with the attenuated and temperature-sensitive phenotype of Sabin strains. The results showed that both mutations and recombination events could affect the phenotype traits of Sabin derivatives and may lead to the reversion of vaccinal strains to neurovirulent ones. The use of phenotypic markers along with the genomic analysis may shed additional light on the molecular determinants of the reversed neurovirulent phenotype of Sabin derivatives.

  5. Imunidade relativa à poliomielite em crianças de zero a dez anos, após o "Quarto Dia Nacional de Vacinação Contra a Poliomielite" com a vacinação oral trivalente, tipo Sabin, em área da Região da Grande São Paulo, SP (Brasil), 1982 Relative immunity to poliomyelitis in children up to ten years of age, after the "4th National Antipoliomyelitis Vaccination Day" with trivalent oral Sabin vaccine, in Greater S. Paulo (Brazil), 1982

    OpenAIRE

    Victório Barbosa; Eliseu Alves Waldman; Mitiko Fujita; Cecília Kitamura; Chang Chung Sing Waldman; José Paulo Gonzaga de Lacerda

    1984-01-01

    Efetuou-se um levantamento soro-epidemiológico, abrangendo 898 crianças, para a verificação da imunidade aos poliovírus 1, 2 e 3 por meio da determinação dos títulos de anticorpos neutralizantes. De 522 crianças, ou seja, de 58,1% da população estudada, foi possível a obtenção de informações referentes à situação vacinal a partir de anotações existentes nas próprias Cadernetas de Vacinação. Neste último sub-grupo foi estudado o estado imunitário em relação ao número de doses de vacina oral ti...

  6. Structure theorems for game trees.

    Science.gov (United States)

    Govindan, Srihari; Wilson, Robert

    2002-06-25

    Kohlberg and Mertens [Kohlberg, E. & Mertens, J. (1986) Econometrica 54, 1003-1039] proved that the graph of the Nash equilibrium correspondence is homeomorphic to its domain when the domain is the space of payoffs in normal-form games. A counterexample disproves the analog for the equilibrium outcome correspondence over the space of payoffs in extensive-form games, but we prove an analog when the space of behavior strategies is perturbed so that every path in the game tree has nonzero probability. Without such perturbations, the graph is the closure of the union of a finite collection of its subsets, each diffeomorphic to a corresponding path-connected open subset of the space of payoffs. As an application, we construct an algorithm for computing equilibria of an extensive-form game with a perturbed strategy space, and thus approximate equilibria of the unperturbed game.

  7. MicroRNA-134 regulates poliovirus replication by IRES targeting

    OpenAIRE

    Bakre, Abhijeet A.; Shim, Byoung-Shik; Tripp, Ralph A.

    2017-01-01

    Global poliovirus eradication efforts include high vaccination coverage with live oral polio vaccine (OPV), surveillance for acute flaccid paralysis, and OPV “mop-up” campaigns. An important objective involves host-directed strategies to reduce PV replication to diminish viral shedding in OPV recipients. In this study, we show that microRNA-134-5p (miR-134) can regulate Sabin-1 replication but not Sabin-2 or Sabin-3 via direct interaction with the PV 5′UTR. Hypochromicity data showed miR-134 ...

  8. The VPI program package adapted to microcomputer for in-core fuel-management

    International Nuclear Information System (INIS)

    Sumitra, T.; Bhongsuwan, T.

    1988-01-01

    The neutron shielding analysis and design program was developed for microcomputer, by modifying the SABINE-3 shielding code which was written for mainframe computers. The program is based on removal-diffusion method and was modified from the SABINE-3 code. The program could be used to calculate shielding for nuclear reactors and neutron source. The accuracy of the program was tested by determining the neutron and gamma dose rate of a test case of Cf-252 source. The results were nearly identical with those obtained from original SABINE-3 which was computed on PRIME 9750 super minicomputer. Computing time was about 65 minutes

  9. Evolution of Evaluation and Assessment in Diverse Audiences in the Digital Age

    Science.gov (United States)

    Eriksson, S. C.

    2015-12-01

    Over the past decades, researchers have learned more about how people think and act and about the social and political aspects of teaching and learning. This understanding has brought changes in researchers' and practitioners' interactions with diverse groups and individuals. This paper addresses evaluation, a process that measures the degree to which learning and project goals are met and factors contributing to or hindering outcomes. Parallels are drawn to learning assessment. The concepts of inclusion, participation, and constructivism (Mertens, 1999; Mertens and Hopson, 2006) now drive best evaluation practices for projects with persons with disabilities (AEA, 2011). This is also true in cases of other people who have been marginalized in STEM fields, e.g. women and underrepresented groups. Inclusion of these stakeholders has important implications for the validity of an evaluation, including the accuracy of results (Jacobson et al, 2012; Gill, 1999; Lee, 1999). The American Indian Higher Education Consortium's framework for indigenous groups incorporates their values and goals into evaluation design and implementation. It is feasible to include participant input in designing the questions and methods of obtaining data, ensuring that issues of access, opportunity, and power (Shuffelbeam, 2001) are taken into consideration. Geoscience projects with u-learning and m-learning provide opportunities to test these theoretical models in innovative programs such as: field work for students with physical disability; underrepresented minority, secondary students using mobile devices in contextualized learning in informal settings; and graduate students using digital maps to enhance traditional field work. This study compares program evaluation methodology of tradition learning with that of programs for diverse groups of students using digital technology. Ref: Mertens doi:10.1177/109821409902000102; Mertens and Hopson DOI: 10.1002/ev.177; AEA http

  10. Mixed Methods Research Prevalence Studies: Field-Specific Studies on the State of the Art of Mixed Methods Research

    OpenAIRE

    Molina-Azorín, José F.; Fetters, Michael D.

    2016-01-01

    The Journal of Mixed Methods Research (JMMR) has always welcomed two main kinds of manuscripts: original empirical articles and methodological/theoretical articles (Creswell & Tashakkori, 2007; Fetters & Freshwater, 2015a; Mertens, 2011). Both types of articles must clearly state methodological aims, review mixed methods literature relative to the methodological aim, and advance the field of mixed methods—empirical articles must address integration (Fetters & Freshwater, 2015b). In this edito...

  11. Stemcell Information: SKIP000871 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ens--Fred H. Gage Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation C...lk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative...s, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal Unive... of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal University--The Sa...enter for Language Ability, Jiangsu Normal University--The Salk Institute for Biological Studies, Laboratory

  12. Sala Mercè, the long lost cinema by Gaudí.

    Directory of Open Access Journals (Sweden)

    Antoni González

    2000-12-01

    Full Text Available Sala Mercè, in the Rambla de Barcelona, was a small playhouse which stood out for showing films among other spectacles. It was opened in 1904 by the painter Lluís Graner. The premises has gone down in history because it was designed by the architect Antoni Gaudí, but until now there were no known photographs of the unusual locale. Loggia has the satisfaction of displaying for the first time some unpublished photographs found by Antoni González, architect and scholar of Gaudí’s oeuvre.

  13. Critical Arts - Vol 14, No 2 (2000)

    African Journals Online (AJOL)

    Alice Area. Felicity Wood. A Postcolonial reading of Mural Art in South Africa. Sabine Marschall. Popular History; Cultural Memory. David Coplan. To Whom it May concern; Or, Is anyone Concerned? The Nyae Nyae Bushman Tape Archive.

  14. Medical Research Pays Off for All Americans

    Science.gov (United States)

    ... the "March of Dimes." It helped develop two vaccines. The first, by Dr. Jonas Salk at the University of Pittsburgh, in 1955, and the second, in 1962, by Dr. Albert Sabin, at the Cincinnati Children's Hospital Medical Center – have ...

  15. Video and Course Context Discussion on Massive Open Online Courses

    DEFF Research Database (Denmark)

    Dubosson, Magali; Emad, Sabine; Broillet, Alexandra

    2014-01-01

    Video and Course Content Discussion on Massive Open Online Courses: An Exploratory Research—Magali Dubosson (HEG Fribourg), Sabine Emad (HEG Genève), Alexandra Broillet (University of Geneva and Webster University Geneva), Constance Kampf (Aarhus University, Denmark)...

  16. LHC/ILC/cosmology interplay

    Indian Academy of Sciences (India)

    SABINE KRAML. Theory Division, Department of Physics, CERN, CH-1211 Geneva 23, Switzerland ... microwave background tell us that most of the mass in the Universe is provided ..... Although constrained by electric dipole moments ...

  17. Oceanographic measurements from the Texas Automated Buoy System (TABS)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Texas Automated Buoy System contains daily oceanographic measurements from seven buoys off the Texas coast from Brownsville to Sabine. The Texas General Land...

  18. Nova libro pri interlingvistiko

    Index Scriptorium Estoniae

    2006-01-01

    Rets rmt.: Blanke, Detlev. Interlinguistische Beiträge : zum Wesen und zur Plansprachen / herausgegeben von Sabine Fiedler. Frankfurt/Main, Berlin ; Bern ; Bruxelles ; New York ; Oxford ; Wien : Europäischer Verlag der Wissenschaften Peter Lang

  19. Feeding behaviour of avian dispersers of nustletoe fnut in the ...

    African Journals Online (AJOL)

    the feeding habits of South African birds, particularly in ... fauna by Baker (1970), supplemented by Godschalk (1981). ... ssp. zeyheri and Viscum combreticola, with incidental. R eprod u ced by Sabin et G atew ...... The flora of South Africa, Vol.

  20. Saksa noor draama ründab / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Viis saksa keeles kirjutavat noorema põlve kirjanikku - Sabine Wen Ching Wang, Andreas Sauter, Bernhard Studlar, Roland Schimmelpfennig ja Kristi Sagor - tuleb vaatama oma näidendite ettelugemise maratoni, mis toimub Von Krahli Teatris

  1. Imunidade relativa à poliomielite em crianças de zero a dez anos, após o "Quarto Dia Nacional de Vacinação Contra a Poliomielite" com a vacinação oral trivalente, tipo Sabin, em área da Região da Grande São Paulo, SP (Brasil), 1982

    OpenAIRE

    Barbosa, Victório; Waldman, Eliseu Alves; Fujita, Mitiko; Kitamura, Cecília; Waldman, Chang Chung Sing; Lacerda, José Paulo Gonzaga de

    1984-01-01

    Efetuou-se um levantamento soro-epidemiológico, abrangendo 898 crianças, para a verificação da imunidade aos poliovírus 1, 2 e 3 por meio da determinação dos títulos de anticorpos neutralizantes. De 522 crianças, ou seja, de 58,1% da população estudada, foi possível a obtenção de informações referentes à situação vacinal a partir de anotações existentes nas próprias Cadernetas de Vacinação. Neste último sub-grupo foi estudado o estado imunitário em relação ao número de doses de vacina oral ti...

  2. Situation Desperate: U.S. Army Engineer Disaster Relief Operations, Origins to 1950

    Science.gov (United States)

    2011-01-01

    the Sabine River sub- office, for example, relayed the following sad report to headquarters: “I regret to report the loss of all property in my...doctor with typhoid vaccine ; the cows and horses and dogs of every description wandering up and down the levees; the fur- niture, every kind of...215 Sabine River, 59 Sacramento Engineer District, 237, 238 Sacramento River, 186, 237 St. Francis River, 85, 87 St. Joe River, 217 St. Louis Engineer

  3. Countering Others’ Insurgencies: Understanding U.S. Small-Footprint Interventions in Local Context

    Science.gov (United States)

    2014-01-01

    2003, pp. 57–73; Michael Colaresi and Sabine C. Carey, “To Kill or to Pro- Counterinsurgency in Comparative Perspective 25 Evidence about lesser...Davenport, 2007a; Christian Davenport, “State Repression and Political Order,” Annual Review of Political Science, Vol. 10, 2007b, pp. 1–23; Sabine C...and overzealous enforcement of sharia, the intimidation of locals, and disruption of development measures like vaccinations and girls’ education

  4. Index of Oral Histories Relating to Naval Research, Development, and Acquisition

    Science.gov (United States)

    1992-07-01

    Mentioned: Byrnes, CAPT James Parsons, RADIA William S. Lauritsen, Dr. Charles C. Sabin , Palmer Aubjects: China Lake pilot plant Michelson Laboratory...119 Seiler, Karl 30 Saalfeld, Dr. Frederick 355, 358 Selwyn, Dr. Philip 355, 358 Sabin , Palmer 266 Senter, Frank 31 Sagdahl, John 266 Sette, Dr...research 157 Lehman, John 222 Libby Board 47, 128 Jaimming devices 210 Life cycle support function 69 Jet Propulsion 308 Light airborne ASW vehicle 235 Jet

  5. Proceedings of the Meeting of the Coastal Engineering Research Board (54th) Held in New Orleans, Louisiana on 4-6 June 1991

    Science.gov (United States)

    1992-04-01

    Sanda, CECW-EG SOUTH PACIFIC DIVISION Mr. Jaime R. Merino, CESPD-ED-W BOARD OF ENGINEERS FOR RIVERS Mr. Jeffrey C. Cole, CESPN-PE-W AND HARBORS Mr...areas. 68 Coastal areas experiencing erosion and economic loss include: a. Sabine Pass to Rollover Pass/Highway 87. In the fall of 1989, the State... Sabine Pass. The closure was prompted by the dangerous conditions resulting from erosion along the highway. In some areas, the highway lies at the

  6. Strategic Plan for the U.S. Climate Change Science Program

    Science.gov (United States)

    2003-07-01

    Program objectives. Source: Chris Sabine , NOAA-PMEL. Chapter 15. International Research and CooperationClimate Change Science Program Strategic Plan...Laboratory Mary C. Erickson National Oceanic and Atmospheric Administration Jaime Esper National Aeronautics and Space Administration 181 Robert Etkins...Sweeney, C., Poison, A., Metzl, N., Tilbrook, B., Bates, N.,Wanninkhof, R., Feely, R.A., Sabine , C., Olafsson, J., and Nojiri,Y., 2002: Global sea-air

  7. Post Doctorate Award on Central America and the Caribbean at St ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    This grant will allow St Antony's College at the University of Oxford to establish a 2-year post doctoral position on Central America and the Caribbean under the leadership of Canadian historian, Margaret MacMillan. The position will be awarded to a scholar from the region, in keeping with IDRC's philosophy that developing ...

  8. Intraosseous neurilemmoma of the fibula

    Energy Technology Data Exchange (ETDEWEB)

    Aoki, J. [Department of Radiology, Shinshu University School of Medicine, Asahi, Matsumoto (Japan); Tanikawa, H. [Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto (Japan); Fujioka, F. [Department of Orthopedic Surgery, Shinshu University School of Medicine, Matsumoto (Japan); Ishii, K. [Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto (Japan); Seo, G.S. [Department of Radiology, Shinshu University School of Medicine, Matsumoto (Japan); Karakida, O. [Department of Radiology, Shinshu University School of Medicine, Matsumoto (Japan); Sone, S. [Department of Radiology, Shinshu University School of Medicine, Matsumoto (Japan)

    1997-01-01

    We present a case of intraosseous neurilemmoma of the fibula in a 56-year-old woman. This case showed the typical radiographic appearance except for the presence of spotted calcifications that mimicked a cartilaginous tumor. Enhanced MR images revealed the heterogeneity of the tumor, which consisted of Antoni type A and B tissue. (orig.). With 4 figs.

  9. Picasso, Chagall ja Mir̤ tulevad müüki

    Index Scriptorium Estoniae

    2001-01-01

    Vaal-galerii avatud 15 tippkunstniku 27 töö näitusmüügist "Suured ja unustamatud", kus eksponeeriti Georges Braque'i, Paul Delvaux, Pablo Picasso, Joan Mir̤, Karel Appeli, Jim Dine, Nike de Saint-Phalle, Marc Chagalli, Antoni Tapiesi, Antonio Saura jt. töid

  10. Reference: 177 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 177 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u15722472i Al-Daoude ...lator of the plant disease resistance protein RPM1. 3 1016-28 15722472 2005 Mar The Plant cell Al-Daoude Antonious|Grant Murray|Ko Jong-Hyun|de Torres Zabala Marta

  11. Analysis of Adjunct Faculty at Des Moines Area Community College: Use and Application of Herzberg's Motivation-Hygiene Theory to Predict Job Satisfaction in Teaching Improvement and Professional Development

    Science.gov (United States)

    Boord, Margi

    2010-01-01

    "During the past two decades, two-year and four-year colleges have increased their reliance on part-time faculty" (Antony & Valadez, 2002, p. 41). The hiring of part-time faculty started as a convenient way to meet the demands for instruction while remaining financially responsible during tough budgetary times. Currently…

  12. Een remix van het strafproces? : Een ‘hiphop-theorie’ van het herstelrecht

    NARCIS (Netherlands)

    Pemberton, A.

    2014-01-01

    Hip-hop and restorative justice may seem odd bedfellows, but according to Antony Pemberton they have more in common than many would assume. In the first place hip-hop shares a common history, at least with restorative justice's modern incarnations, spanning four decades, to become a similarly global

  13. Journal of Chemical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The effectiveness of solvation as a dynamical probe in such complex systems has been discussed. pp 123-133. Time-resolved fluorescence analysis of the mobile flavin cofactor in -hydroxybenzoate hydroxylase · Petra A W Van Den Berg Koert Grever Arie Van Hoek Willem J H Van Berkel Antonie J W G Visser.

  14. Roads Scholars: Part-Time Faculty Job Satisfaction in Community Colleges

    Science.gov (United States)

    Kramer, Allison L.; Gloeckner, Gene W.; Jacoby, Daniel

    2014-01-01

    Are part-time faculty members satisfied with their roles in higher education? Data from part-time faculty responses regarding their experiences in higher education vary. Valadez and Antony (2001) analyzed data from 6,811 part-time faculty collected from the National Center for Education Statistics' (NCES) 1992-1993 National Survey of Postsecondary…

  15. Factors Affecting Part-Time Faculty Job Satisfaction in the Colorado Community College System

    Science.gov (United States)

    Cashwell, Allison L.

    2009-01-01

    How do part-time faculty members in community colleges view their roles? Data from part-time faculty responses regarding their experiences in higher education vary. Valadez and Antony (2001) analyzed data from 6,811 part-time faculty collected from the National Center for Education Statistics' (NCES) 1992-1993 National Survey of Postsecondary…

  16. Using US EPA’s Chemical Safety for Sustainability’s Comptox Chemistry Dashboard and Tools for Bioactivity, Chemical and Toxicokinetic Modeling Analyses (Course at 2017 ISES Annual Meeting)

    Science.gov (United States)

    Title: Using US EPA’s Chemical Safety for Sustainability’s Comptox Chemistry Dashboard and Tools for Bioactivity, Chemical and Toxicokinetic Modeling Analyses • Class format: half-day (4 hours) • Course leader(s): Barbara A. Wetmore and Antony J. Williams,...

  17. Knots and Links

    Indian Academy of Sciences (India)

    in a fashion similar to sound waves, whose medium is air. Ether was believed ..... [3] Colin C Adams, The Knot Book, W H Freeman and Company, New. York. ... [5] Kelly S Chichak, Stuart j CantriU, Antony R Pease, Sheng-Hsien. Chiu, Gareth ...

  18. High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging

    NARCIS (Netherlands)

    Bel, A.; Vos, P. H.; Rodrigus, P. T.; Creutzberg, C. L.; Visser, A. G.; Stroom, J. C.; Lebesque, J. V.

    1996-01-01

    PURPOSE: To investigate in three institutions, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis [AvL]), Dr. Daniel den Hoed Cancer Center (DDHC), and Dr, Bernard Verbeeten Institute (BVI), how much the patient setup accuracy for irradiation of prostate cancer can be improved by an

  19. Doris Lessing and the

    African Journals Online (AJOL)

    Prof. Dennis Ocholla

    Antony Chennells explains that “an obvious form of anti-colonial resistance to ... How then is Doris Lessing connected to Indigenous Knowledge Systems or the .... The Old Chief has no power in this situation – colonialism has robbed him of ...

  20. High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging

    NARCIS (Netherlands)

    A. Bel (Arjan); P.H. Vos (Pieter); P. Rodrigus (Patrick); C.L. Creutzberg (Carien); A.G. Visser (Andries); J.Ch. Stroom (Joep); J.V. Lebesque (Joos)

    1996-01-01

    textabstractPurpose: To investigate in three institutions, The Netherlands Cancer Institute (Antoni van Leeuwenhoek Huis [AvL]), Dr. Daniel den Hoed Cancer Center (DDHC), and Dr. Bernard Verbeeten Institute (BVI), how much the patient setup accuracy for irradiation of prostate cancer can be improved

  1. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Numerical studies and a real-world experiment for a watch cambered surface polishing platform have verified performance and applicability of our proposed design. pp 821-834. Progressive combustion in SI-Engines—Experimental investigation on influence of combustion related parameters · R Harish Kumar A J Antony.

  2. V stenah muzeja pulsirujet gorod / Kiwa

    Index Scriptorium Estoniae

    Kiwa, pseud., 1975-

    2008-01-01

    Näitus "Koht, mis paneb liikuma" Kumu Kunstimuuseumis. Kuraator Eha Komissarov. Grafitikunstnike Antoni, Uku ja Remi ruumiinstallatsioonist "Ajaviil". Reet Ausi, Ville Hyvöneni, HULA ja Tartu Kõrgema Kunstikooli tudengite ruumiinstallatsioonist "Üle prahi". Maarit Murka töö "Fotofoobia". Raoul Kurvitza arvutikunsti teosest "Pentatonic Color System II"

  3. Muuseumiseinte vahel tuksleb linn / Kiwa

    Index Scriptorium Estoniae

    Kiwa, pseud., 1975-

    2008-01-01

    Näitus "Koht, mis paneb liikuma" Kumu Kunstimuuseumis. Grafitikunstnike Antoni, Uku ja Remi ruumiinstallatsioonist "Ajaviil". Reet Ausi, Ville Hyvöneni, HULA ja Tartu kõrgema kunstikooli tudengite ruumiinstallatsioonist "Üle prahi". Raoul Kurvitza arvutikunsti teosest "Pentatonic Color System II". Eksponeeritakse ka Maarit Murka ja Kaido Ole töid

  4. Novel Strategies for Production of Medium and High Chain Length Alcohols

    NARCIS (Netherlands)

    Lopez Contreras, A.M.; Kuit, W.; Springer, J.; Claassen, P.A.M.

    2011-01-01

    Fermentation-derived ethanol is currently widely used as transport fuel, both as such or as a blending component in gasoline (Antoni et al. 2007; Mielenz 2001). However, longer chain alcohols have higher energy densities and are less soluble in water than ethanol, which are important advantages for

  5. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. B N Upadhyay. Articles written in Pramana – Journal of Physics. Volume 82 Issue 1 January 2014 pp 143-146 Contributed Papers. Erbium–ytterbium fibre laser emitting more than 13W of power in 1.55 m region · Srikanth Gurram Antony Kuruvilla Rajpal Singh Blacius Ekka ...

  6. Plagiarism and Prosecution: A New Approach at Air University.

    Science.gov (United States)

    1988-04-01

    Isocrates, Demosthenes, Aes- chines, Menander and Plutarch indulged in it at times. Aristotle lifted whole pages from Democritus. . . . And Plato...There are speeches in Antony and Cleopatra which * are pure Plutarch . Malone painstakingly analyzed Parts I, II, and III of Henry VI, and came to the

  7. JULIUS CAESAR. PLUTARCH'S LIVES. AUTOBIOGRAPHY. LITERATURE CURRICULUM IV, TEACHER VERSION.

    Science.gov (United States)

    KITZHABER, ALBERT R.

    THIS 10TH-GRADE ENGLISH CURRICULUM GUIDE WAS PREPARED TO ASSIST TEACHERS IN THE PRESENTATION OF AN ENRICHED READING AND STUDY PROGRAM OF SHAKESPEARE'S "JULIUS CAESAR," GIVING SOME ATTENTION TO PLUTARCH'S BIOGRAPHIES OF CAESAR, BRUTUS, AND MARK ANTONY WHICH BEAR DIRECTLY ON SHAKESPEARE'S PLAY. AN INSTRUCTIONAL UNIT ON…

  8. Comedy in Plutarch’s Parallel Lives

    Directory of Open Access Journals (Sweden)

    Sophia Xenophontos

    2012-11-01

    Full Text Available Plutarch quotes Attic comedy as evidence, but he also uses both invective and stereotypes from comedy in order to illustrate and judge the character of his protagonists, as seen in the Lives of Demetrius, Antony, Pericles, and Fabius Maximus.

  9. JULIUS CAESAR. PLUTARCH'S LIVES. AUTOBIOGRAPHY. LITERATURE CURRICULUM IV, STUDENT VERSION.

    Science.gov (United States)

    KITZHABER, ALBERT R.

    THIS 10TH-GRADE STUDENT GUIDE POSED SOME QUESTIONS AND CLARIFIED OTHERS ON SHAKESPEARE'S "JULIUS CAESAR," AND PRESENTED SHORT SELECTIONS FROM PLUTARCH'S "LIVES" (ON CAESAR, BRUTUS, AND MARK ANTONY) WITH ACCOMPANYING DISCUSSION QUESTIONS. A UNIT OF AUTOBIOGRAPHICAL READINGS OF EARLY LIFE EXPERIENCES WAS ALSO OUTLINED. BY…

  10. Tõlkeloo arvukad dimensioonid / Hannu K. Riikonen

    Index Scriptorium Estoniae

    Riikonen, Hannu K.

    2012-01-01

    Arvustus: Antonie Chalvin, Anne Lange, Daniele Monticelli (Eds.) Between cultures and texts : itineraries in translation history = Entre les cultures et les textes : itinéraires en histoire de la traduction. Frankfurt am Main-Berlin-Bern-Bruxelles-New York-Oxford-Wien 2011

  11. Sadhana | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana. KARTHIK CHANDRAN. Articles written in Sadhana. Volume 42 Issue 6 June 2017 pp 817-826. Deterministic oscillatory search: a new meta-heuristic optimization algorithm · N ARCHANA R VIDHYAPRIYA ANTONY BENEDICT KARTHIK CHANDRAN · More Details Abstract Fulltext PDF.

  12. Tippkunstnike müügiedu Tallinnas / Georg Poslawski

    Index Scriptorium Estoniae

    Poslawski, Georg

    1998-01-01

    Müüginäitustest. 3.-21. märtsini Vaal-galeriis Antoni T̉piesi graafikakollektsioon aastatest 1973-1994. 5. märtsil pakkus Deco galerii Tallinna WTCs Salvador Dali graafikat - üheksat litograafiat sarjast "Lilled". Kunstnikest, nende loomingust. Hindadest.

  13. Intraosseous neurilemmoma of the fibula

    International Nuclear Information System (INIS)

    Aoki, J.; Tanikawa, H.; Fujioka, F.; Ishii, K.; Seo, G.S.; Karakida, O.; Sone, S.

    1997-01-01

    We present a case of intraosseous neurilemmoma of the fibula in a 56-year-old woman. This case showed the typical radiographic appearance except for the presence of spotted calcifications that mimicked a cartilaginous tumor. Enhanced MR images revealed the heterogeneity of the tumor, which consisted of Antoni type A and B tissue. (orig.). With 4 figs

  14. (AJST) DETERMINATION DE LA QUALITÉ DU PAIN DE SUCRE A ...

    African Journals Online (AJOL)

    RÉFÉRENCES. Arguello-Morales, M., Sanchez-Gonzales, M., Canedo, M.,. Quirasco, M., Farres, A., Lopez-Munguia, A., (2005),. Proteolytic modification of Leuconostoc mesenteroides B-512F dextransucrase, Antonie Van. Leewenhoek, 87(2):131-141. Badui, J.D.S., (1995), Quimica de alimentos, 3a edicion,. 62-65, Edition ...

  15. Dvazhdõ dva pjat / Grigori Pomerants

    Index Scriptorium Estoniae

    Pomerants, Grigori, 1918-

    2005-01-01

    Dostojevski loomingu filosoofiline käsitlus, Antoni Surozhski ja Sergei Averintsevi religioossete vaadete erinevusest. Autor usub, et nende erinevate vaadete vahel, mida võiks iseloomustada lühidalt kaks korda kas on viis ja kaks korda kaks on neli, on võimalik dialoog

  16. 5 kandidaati nüüdisaegse arhitektuuri auhinnale / Maris Meiesaar

    Index Scriptorium Estoniae

    Meiessaar, Maris

    2009-01-01

    Euroopa Liidu Mies van der Rohe nim. preemia finalistid: Atelier Marc Barani (Nice'i trammivõrk ja jalakäijate ala), Massimiliano ja Doriana Fuksas (Zenith Music Hall Strasbourgis), Grafton Architects (Luigi Bocconi ülikool Milanos), Snohetta (Norra ooperi- ja balletiteater Oslos), RCR Aranda Pigem Vilalta Arquitectes (Barcelona Sant Antoni linnaosa raamatukogu, vanurite keskus, linnaruum). Loetletud seitse kandidaati Eestist

  17. M K Jayaraj

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. M K Jayaraj. Articles written in Bulletin of Materials Science. Volume 25 Issue 3 June 2002 pp 227-230 Thin Films. Transparent conducting zinc oxide thin film prepared by off-axis rf magnetron sputtering · M K Jayaraj Aldrin Antony Manoj Ramachandran · More Details Abstract ...

  18. Kolm väliseesti statistikut / Tõnu Kollo

    Index Scriptorium Estoniae

    Kollo, Tõnu, 1948-

    2011-01-01

    Ettekanne 22. aprillil 2010 toimunud konverentsilt "Eesti teadlased välismaal". Kokkuvõte majandusstatistiku Antoni Kesküla ja noorema põlvkonna meditsiinistatistikute Endel John Orava ning Carl Martin Tammemägi uurimistööst

  19. On the upwelling off the Southern Tip and along the west coast of India

    Digital Repository Service at National Institute of Oceanography (India)

    Smitha, B.R.; Sanjeevan, V.N.; VimalKumar, K.G.; Revichandran, C.

    downloaded from CDC-NOAA websites; in situ data were obtained from the CMLRE Data Centre; and chlo- rophyll data were retrieved from GSFC NASA. This is NIO contribution 4283. LITERATURE CITED ANTONY, M.K.; NARAYANA SWAMY, G., and SOMAYAJULU, Y.K., 2002...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. R S Sharma. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 391-405. Current status of fertility control methods in India · R S Sharma M Rajalakshmi D Antony Jeyaraj · More Details Abstract Fulltext PDF. Approximately 48.2% of couples of 15 to 49 ...

  1. An Alternative Perspective on Simulations

    Science.gov (United States)

    Cone, Theresa Purcell; Cone, Stephen L.

    2016-01-01

    In this letter to the editor of "Strategies: A Journal for Physical and Sport Educators", the authors write that they recently read the "Strategies" article by Antony Parish, "Using Immersion as a Teaching Method to Develop an Understanding, Appreciation and Empathy for Special Needs Populations," in the May/June 2016…

  2. 'Most Rare Workmen': Optical Practitioners in Early Seventeenth-Century Delft

    NARCIS (Netherlands)

    Zuidervaart, Huib J.; Rijks, Marlise

    2015-01-01

    A special interest in optics among various seventeenth-century painters living in the Dutch city of Delft has intrigued historians, including art historians, for a long time. Equally, the impressive career of the Delft microscopist Antoni van Leeuwenhoek has been studied by many historians of

  3. European science in the Enlightenment and the discovery of the insect parasitoid life cycle in The Netherlands and Great Britain

    NARCIS (Netherlands)

    Lenteren, van J.C.; Godfray, H.C.J.

    2005-01-01

    The authors most frequently credited for the European discovery of the parasitoid life cycle are Antoni van Leeuwenhoek, John Ray and Antonio Vallisnieri around the year 1700. Many other European authors published works on entomology in the 17th century and mentioned insects that we now recognize as

  4. A Comparison of the Polish and Soviet Armaments Decisionmaking Systems.

    Science.gov (United States)

    1981-01-01

    translated and published under the auspices of the U.S. Air Force, Washington, D.C., 1977, p. 51; Antoni Rogucki, " Teoria potencjalu wojenno-ekonomicznego a...proizvodstvennogo oborudovaniia i sistema amortisatsii" (Managing the Renovation of the Production Equip- ment and Amortization System), Planovoe khoziaistvo, 1979

  5. WAJM 28(3)FINAL6cd.pmd

    African Journals Online (AJOL)

    daddy

    Giant Guteal Schwannoma avec l'extension dans le Bassin : un rapport de cas ... complexe géant schwannoma et accentuer la valeur d'enquêtes étendues en .... section of the slide shows the Antoni Type ... and diathermy coagulation.

  6. Disainikaart : Hispaania / Eve Arpo

    Index Scriptorium Estoniae

    Arpo, Eve

    2009-01-01

    Hispaania tuntumad arhitektid, disainerid, kunstnikud. Antoni Gaudí (1852-1926), Pablo Picasso (1881-1973), Félix Candela (1910-1997), Marti Guixe, Santiago Calatrava, Herme Ciscar, Monica Garcia, Roger Arquer, Patricia Urquiola, Jaime Hayón

  7. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis

    DEFF Research Database (Denmark)

    Wahn, Ulrich; Tabar, Ana; Kuna, Piotr

    2009-01-01

    BACKGROUND: The efficacy and safety of the 300-index of reactivity (IR) dose of 5-grass-pollen sublingual immunotherapy (SLIT) tablets (Stallergènes, Antony, France) have been demonstrated for the treatment of hay fever in adults. OBJECTIVE: We sought to assess the efficacy and safety of this tab...

  8. Gaudi Goes Green

    Science.gov (United States)

    Thomas, Suzanne

    2011-01-01

    When the author traveled to the city of Barcelona, Spain to see the still-unfinished La Sagrada Familia in person, she marveled at the magical genius of Antoni Gaudi's masterpiece. Inspired by Gaudi's whimsical tile work and cathedral towers, the author developed an art project that engages students in a creative experience, which combined art…

  9. Addressing the Gap between Case Law and Professional Practice: A Response to Zirkel

    Science.gov (United States)

    Smith, Carl; Katsiyannis, Antonis; Ryan, Joseph

    2014-01-01

    In this article, authors Carl Smith, Antonis Katsiyannis, and Joseph Ryan respond to Zirkel's most recent article, "The Law in the Special Education Literature: A Brief Legal Critique," published in this issue of "Behavioral Disorders." Smith, Katsiyannis, and Ryan begin their response by saying that "The Law in the…

  10. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. J Zacharias. Articles written in Pramana – Journal of Physics. Volume 59 Issue 5 November 2002 pp 849-858. Superconducting linear accelerator system for NSC · P N Prakash T S Datta B P Ajith Kumar J Antony P Barua J Chacko A Choudhury G K Chadhari S Ghosh S Kar ...

  11. Bacterioplankton Community Dynamics and Nutrient Availability in a Shallow Well Mixed Estuary of the Northern Gulf of Mexico.

    Science.gov (United States)

    Hoch, M. P.

    2016-02-01

    Sabine Lake Estuary is a shallow, well mixed, tidal lagoon of the Northern Gulf of Mexico. This study defines the bacterioplankton community composition and factors that may influence its variation in Sabine Lake Estuary. Twenty physicochemical parameters, phytoplankton photopigments, and bacterial 16SrDNA sequences were analyzed seasonally from twelve sites ranging from the inflows of Sabine and Neches Rivers to the Sabine Pass outflow. Photopigments were used to estimate phytoplankton groups via CHEMTAX, and bacterioplankton 16SrDNA sequences of 97% similarity were quantified and taxa identified. Nutrient availability experiments were conducted on bacterioplankton. Notable seasonal differences were seen in six of the ten most common (>3% of total sequences) classes of bacterioplankton. Canonical correspondence analysis (CCA) of common classes was used to explore physiochemical parameters and phytoplankton groups influencing variation in the bacterioplankton. Alphaproteobacteria were most abundant throughout the year. Opitutae, Actinobacteria, Sphingobacteria, and Beta-proteobacteria were strongly influenced by conditions with higher TDN, DOC, turbidity, and Chlorophytes during winter when high river discharges reduced salinity. Planctomycetacia were most prevalent during spring and coincide with predominance of Cryptophytes. In summer and fall the aforementioned classes decline, and there is an increase in Synechococcophycideae. Nitrogen was least available to bacterioplankton during summer and fall. Clearer, warmer and more saline conditions with lower DOC reflect tidal movement of seawater into the estuary when river discharges were low, conditions favorable for Synechococcophycidea. Seasonal fluctuations in physicochemical conditions and certain phytoplankton groups influence the variation in the bacterioplankton community in Sabine Lake Estuary.

  12. Index to FAA Office of Aviation Medicine Reports: 1961 through 1998.

    Science.gov (United States)

    1999-01-01

    marihuana . AD775889 73-13 Tobias, J. V., and Irons, F. M: Reception of distorted speech. AD777564 73-14 Thackray, R. I., Jones, K. N., and...involved in midair collisions. ADAO16277 75-6 Lewis, M. F., Ferraro, D. P., Mertens, H. W., and Steen, J. A: Interaction between marihuana and...71-17. ... human tolerance, 62-6. ... marihuana effects on performance, 75-6. ... oxygen masks, efficiency of, 62-21, 66-7, 66-9, 66-20, 67-3, 67

  13. The Role of Passive Film Growth Kinetics and Properties in Stress Corrosion and Crevice Corrosion Susceptibility

    Science.gov (United States)

    1975-10-01

    Kleinzack-Mathieu Cl. Mertens, J. Meunier, Cl. Vanlengenhaghe, L. de Munck, L. Laureys , L. N. Nellmans, and M . Warzu, Corrosion Science, 3, 239 (1963). 10) H...312O448 DEPARTMENT OF COMMERCE 11. CoMfact/Grat No. WASHINGTON. D.C. 20234 M 1 mRO36-082 12. Spoasoring Organizstion N~me and Complete Address (Street...Ill. Undw Swnay Dr. 111"y Alu-Juhws. AsnluaM ScWaty fr Salome and T0e@* M /WY NATIONAL UMAU OF STANDAWS. Ernest Ambler. Acting Dimwt PART I (To be

  14. Stemcell Information: SKIP000866 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  15. Stemcell Information: SKIP000868 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  16. Stemcell Information: SKIP000869 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  17. Stemcell Information: SKIP000867 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Jerome Mertens--Fred H. Gage Jiangsu Collaborative Innovation Center for Language Ability, Jiangsu Normal U...niversity--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovatio...Biological Studies, Laboratory of Genetics Jiangsu Collaborative Innovation Center for Language Ability, Jia...ngsu Normal University--The Salk Institute for Biological Studies, Laboratory of Genetics Jiangsu Collaborat...nstitute for Biological Studies, Laboratory of Genetics Jun Yao--Fred H. Gage Jun Yao--Fred H. Gage Information Only Jiangsu Collabor

  18. First- and Second-level Bayesian Inference of Flow Resistivity of Sound Absorber and Room’s Influence

    DEFF Research Database (Denmark)

    Choi, Sang-Hyeon; Lee, Ikjin; Jeong, Cheol-Ho

    2016-01-01

    Sabine absorption coefficient is a widely used one deduced from reverberation time measurements via the Sabine equation. First- and second-level Bayesian analysis are used to estimate the flow resistivity of a sound absorber and the influences of the test chambers from Sabine absorption...... coefficients measured in 13 different reverberation chambers. The first-level Bayesian analysis is more general than the second-level Bayesian analysis. Sharper posterior distribution can be acquired by the second-level Bayesian analysis than the one by the first-level Bayesian analysis because more data...... are used to set more reliable prior distribution. The estimated room’s influences by the first- and the second-level Bayesian analyses are similar to the estimated results by the mean absolute error minimization....

  19. Estudio comparativo de una reacción sorologica para el diagnostico de la toxoplasmose

    Directory of Open Access Journals (Sweden)

    Francisco Biagi

    1973-12-01

    Full Text Available Se estudiaron 73 sueros humanos mediante la RSF y la reacción de floculación, encontrándose una buena correlación de los resultados, por lo que se considera que esta última es útil especialmente para fines de detección, considerando su sencillez y bajo costo.73 human sera were submitted to Sabin Feldman and, floculation reactions for the diagnosis of toxoplasmcsis. Floculation test proved to be useful, providing similar results to those obtained with Sabin-Feldman reaction.

  20. Production of high titer attenuated poliovirus strains on the serum-free PER.C6(®) cell culture platform for the generation of safe and affordable next generation IPV.

    Science.gov (United States)

    Sanders, Barbara P; Oakes, Isabel de los Rios; van Hoek, Vladimir; Liu, Ying; Marissen, Wilfred; Minor, Philip D; Wimmer, Eckard; Schuitemaker, Hanneke; Custers, Jerome H H V; Macadam, Andrew; Cello, Jeronimo; Edo-Matas, Diana

    2015-11-27

    As poliovirus eradication draws closer, alternative Inactivated Poliovirus Vaccines (IPV) are needed to overcome the risks associated with continued use of the Oral Poliovirus Vaccine and of neurovirulent strains used during manufacture of conventional (c) IPV. We have previously demonstrated the susceptibility of the PER.C6(®) cell line to cIPV strains; here we investigated the suspension cell culture platform for growth of attenuated poliovirus strains. We examined attenuated Sabin strain productivity on the PER.C6(®) cell platform compared to the conventional Vero cell platform. The suitability of the suspension cell platform for propagation of rationally-attenuated poliovirus strains (stabilized Sabin type 3 S19 derivatives and genetically attenuated and stabilized MonoCre(X) strains), was also assessed. Yields were quantified by infectious titer determination and D-antigen ELISA using either serotype-specific polyclonal rabbit sera for Sabin strains or monoclonal cIPV-strain-specific antibodies for cIPV, S19 and MonoCre(X) strains. PER.C6(®) cells supported the replication of Sabin strains to yields of infectious titers that were in the range of cIPV strains at 32.5°C. Sabin strains achieved 30-fold higher yields (pSabin strain productivity on the PER.C6(®) cell platform was maintained at 10l scale. Yields of infectious titers of S19 and MonoCre(X) strains were 0.5-1 log10 lower than seen for cIPV strains, whereas D-antigen yield and productivities in doses/ml using rationally-attenuated strains were in line with yields reported for cIPV strains. Sabin and rationally-attenuated polioviruses can be grown to high infectious titers and D-antigen yields. Sabin strain infection shows increased productivity on the PER.C6(®) cell platform as compared to the conventional Vero cell platform. Novel cell platforms with the potential for higher yields could contribute to increased affordability of a next generation of IPV vaccines needed for achieving and

  1. Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone

    Science.gov (United States)

    2014-07-01

    1743-422X-8-478 6. Sabin AB, Schlesinger RW. Production of immunity to dengue with virus modified by propagation in mice. Science. 1945;101:640–2...http://dx.doi.org/10.1126/science.101.2634.640 7. Sabin AB. The dengue group of viruses and its family relationships. Bacteriol Rev. 1950;14:225...immunization with attenuated (TC-83) VEE virus vaccine . J Infect Dis. 1977;136:354–9. http://dx.doi.org/10.1093/infdis/136.3.354 21. Lanciotti RS, Roehrig JT

  2. Two-Dimensional Flow Modeling: Proceedings of the National U.S. Army Corps of Engineers-Sponsored Seminar on the Two-Dimensional Flow Modeling (1st), 7-9 July 1981,

    Science.gov (United States)

    1982-03-01

    Niederauer (Enerly, Inc.), Lee Butler (WES), Danny Fread (NOAA). Theodor Strelkoff (Hydraulic Enuineering), Robert MacArthur (HEC), Warren Mellema (4RD), Jaime ...Mississippi, Sabine , and Neches Rivers as shown in Figures 1 and 2. Work is on-going to gradually extend this service to other Gulf Coast rivers in Texas...MEXICO FIG. 2-HURRICANE STORM SURGE FORECASTING OF SABINE AND NECHES RIVERS 16 DAM -Z - PLAN VIEW- SEC. VIEW f-f FIG. 3- DAM-BREAK FLOOD ONTO A VERY WIDE

  3. Increasing Rates of Obesity Among HIV-Infected Persons During the HIV Epidemic

    Science.gov (United States)

    2010-04-01

    Sabin CA, Youle M, Madge S, Tyrer M, et al. (1999) Changes in AIDS-defining illnesses in a London clinic, 1987–1998. J Acquir Immune Defic Syndr 21...from the DAD study. AIDS 17: 1179–93. 31. Friis-Møller N, Sabin CA, Weber R, Reiss P, El-Sadr WM, et al. (2003) Data Collection on Adverse Events of Anti...weight. N Engl J Med 341: 427–34. 37. Duran AC, Almeida LB, Segurado AA, Jaime PC (2008) Diet quality of persons living with HIV/AIDS on highly active

  4. Different radiation impedance models for finite porous materials

    DEFF Research Database (Denmark)

    Nolan, Melanie; Jeong, Cheol-Ho; Brunskog, Jonas

    2015-01-01

    The Sabine absorption coefficients of finite absorbers are measured in a reverberation chamber according to the international standard ISO 354. They vary with the specimen size essentially due to diffraction at the specimen edges, which can be seen as the radiation impedance differing from...... the infinite case. Thus, in order to predict the Sabine absorption coefficients of finite porous samples, one can incorporate models of the radiation impedance. In this study, different radiation impedance models are compared with two experimental examples. Thomasson’s model is compared to Rhazi’s method when...

  5. Das Leben, der Tod und die staubige Wiedergeburt

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2014-01-01

    theory formations. The project SAY(IL)ING by Sabine Kacunko heads exactly into this direction. To short-cut the significance-open surface of the images with the development of the art and media history is the most insightful approach to access Sabine Kacunko‘s work. The impossibility to penetrate...... into this work over the surface of the artist‘s images poses inevitably the question about the meaning and expressiveness of the (re)presented formation and decay processes of the photographic, videographic and digital image. Out of the chaos and the method, with which she artistically perpetrates death and its...

  6. AN INTERESTING CASE OF ANCIENT SCHWANNOMA

    Directory of Open Access Journals (Sweden)

    Binu

    2015-01-01

    Full Text Available INTRODUCTION : Schwannoma is a common benign tumour of nerve sheath. Degenerating type of schwannoma is called ancient schwannoma. Ancient schwannomas of scalp are rare and are often misdiagnosed as sebaceous cyst or dermoid cyst. CASE REPORT : We present a thirty two year old male presented with scalp swel ling of eight years duration. X - ray showed no intracranial extension. He underwent excision of the tumour and histopathology was reported as ancient schwannoma. DISCUSSION : Histopathologically , ancient schwannomas charecterised by cellular Antoni type A ar eas and less cellular Antoni type - B areas. 9 th , 7 th , 11 th , 5 th and 4 th cranial nerves are often affected and may be associated with multiple neuro fibramatosis (Von - Recklinghausen’s disease. Impact : Case is presented for its rarity and possible pre - operative misdiagnosis

  7. Sympathetic chain Schwannoma

    International Nuclear Information System (INIS)

    Al-Mashat, Faisal M.

    2009-01-01

    Schwannomas are rare, benign, slowly growing tumors arising from Schwann cells that line nerve sheaths. Schwannomas arising from the cervical sympathetic chain are extremely rare. Here, we report a case of a 70-year-old man who presented with only an asymptomatic neck mass. Physical examination revealed a left sided Horner syndrome and a neck mass with transmitted pulsation and anterior displacement of the carotid artery. Computed tomography (CT) showed a well-defined non-enhancing mass with vascular displacement. The nerve of origin of this encapsulated tumor was the sympathetic chain. The tumor was excised completely intact. The pathologic diagnosis was Schwannoma (Antoni type A and Antoni type B). The patient has been well and free of tumor recurrence for 14 months with persistence of asymptomatic left sided Horner syndrome. The clinical, radiological and pathological evaluations, therapy and postoperative complications of this tumor are discussed. (author)

  8. Intraosseous neurilemmoma of the mandible: Report of a rare ancient type

    Directory of Open Access Journals (Sweden)

    Gholamreza Jahanshahi

    2011-01-01

    Intraosseous schwannomas especially ancient ones are rare tumors. Here we present a case of intraosseous ancient schwannoma in the lower jaw of an 11-year-old girl which caused a non-tender expansion. Radiographic examination showed a well-circumscribed, unilocular radiolucent lesion with thin sclerotic borders in the mandibular body and the ramus. Histopathologic examination of the incisional biopsy showed areas of typical Antoni A with verocay bodies and Antoni B that was strongly suggestive of a schwannoma. Complete excision of the lesion was done under general anesthesia. The histopathologic examination confirmed the primary diagnosis and also degenerative changes such as hyalinization and calcification. Based on these findings, the diagnosis of ancient schwannoma was made. No recurrence was observed in the follow-up examination after 3 months.

  9. A Maritime Approach to Countering Horn of Africa Piracy

    Science.gov (United States)

    2012-04-26

    rights of all others. Additionally, the rights enjoyed by pirates must be balanced against concerns for the common good, mainly the safety of... worklife /08/27/woman.pirate/index.html (accessed 18 December 2011) . 27 Antony, 42. 28 Ibid., 44. 29 The British Navy engaged two notorious...http://edition.cnn.com/2007/LIVING/ worklife /08/27/woman.pirate/index.html (accessed 18 December 2011) . Kontorovich, Eugene. “A Guantanamo on the

  10. XI Jornades d’Educació Emocional. Educació emocional i família

    OpenAIRE

    Barredo Gutiérrez, Blanca; Bisquerra Alzina, Rafael; Blanco Cuch, Aida; Giner, Antoni; Pérez Escoda, Núria; Tey, Amèlia

    2014-01-01

    Barredo Gutiérrez, Blanca; Bizquerra Alzina, Rafel; García Aguilar, Núria; Giner Tarrida, Antoni; Pérez Escoda, Núria; Tey Teijón, Amelia (Coords.). XI Jornades d’Educació Emocional/XI Jornadas de Educación Emocional. Barcelona, Universitat de Barcelona (Institut de Ciències de l’Educació), 2015. Document electrònic.

  11. La difusión de la teoría evolucionista de Lamarck en la revista La Abeja (1862-1870) de Barcelona

    OpenAIRE

    Camós Cabeceran, Agustí

    1997-01-01

    Between 1862 and 1864 Lamarck's works were diffused in Spain through a magazine called La Abeja which was edited by Antoni Bergnes de las Casas, and published in Barcelona. This may reveal a more important influence of Lamarck's theory on the introduction of evolutionary theories in Spain. La Abeja includes the translation of the Histoire naturelle des végétaux where Lamarck incorporated an early explanation of his theory of evolution; and a series of anonymous articles about the reproduction...

  12. Relatos sobre discapacidad y economías de a pie

    OpenAIRE

    Ortells Roca, Miguel Juan; Ortí Porcar, María José; Gimeno Nebot, Cèsar; Grupo de trabajo sobre Discapacidad

    2013-01-01

    ÍNDICE .PRÓLOGO, Miquel Ortells . EL NEGOCIO DEL MATERIAL ORTOPÉDICO, Cèsar Gimeno . HABLAR ELECTRÓNICAMENTE, Sergio Sanahuja . MI CORAZÓN NO RECHAZA EL TRABAJO, Antoni Romero . LAS ADAPTACIONES INFORMÁTICAS PARECEN . PARA ASTRONAUTAS: ¡ESTÁN POR LA ÓRBITA!, Sergio Sanahuja . ALGUIEN ESTÁ HACIENDO NEGOCIOS CON MI DISCAPACIDAD, Santos Cuadros . A CUESTAS CON EL LUJO DE MI DISCAPACIDAD , María Victoria. BENEFICIOS Y GASTOS EXTRA AL COMPRAR...

  13. The Archival materials of amateur archaeologists active in Lithuania - in the State Archaeological Museum in Warsaw

    OpenAIRE

    Krajewska, Maria

    2009-01-01

    The Documentations Department of the State Archaeological Museum in Warsaw has in its keeping papers of Michał Eustachy Brensztejn, Maria Butrymówna, Wandalin Szukiewicz, Julian Talko-Hryncewicz and Antoni Zaborski. Of these the largest category are letters received by Erazm Majewski (1858-1922) in the period 1897-1910 which are now a part of Majewski's legacy. They document exchange and cooperation of their authors with Majewski in the field of archaeology and ethnography. Erazm Majewski was...

  14. Living Colloidal Metal Particles from Solvated Metal Atoms. Clustering of Metal Atoms in Organic Media 15.

    Science.gov (United States)

    1986-09-23

    attributed to these solutions, especially toward heart disease. And in 1618 Antoni published Panacea Aurea : Auro Potabile 4 which centered on the...probably a slow process (discussed next under the electrophoresis section ). Electrophoresis: Electrophoresis, the movement of charged particles in...electrical properties. Experimental Section Preparation of a Typical Au-Acetone Colloid The metal atom reactor has been described previo sly. 3 9 ’ 5 9 ’ 6 0

  15. Pop-up Library Makerspace: academic libraries provide flexible, supportive space to explore emerging technologies.

    OpenAIRE

    Groves, Antony

    2016-01-01

    The word Makerspace is a general term for a place where people get together to make things, create things and\\ud learn together. Antony Groves presents a look at a recent university library experiment hosting a pop-up makerspace. Working with local edtech leaders MakerClub and colleagues the library organised a two-hour workshop which offered the opportunity for students and staff to explore emerging technologies.

  16. The Free Trade Area of the Americas: Can Regional Economic Integration Lead to Greater Cooperation on Security?

    Science.gov (United States)

    2002-12-01

    Brazilian Air Force has been testing a new surveillance system called Sistema de Vigilancia da Amazonia (SIVAM), designed to...2000 Online Database, 23 April 1998 and “Plan de seguridad para la triple frontera,” Ser en el 2000 Online Database, 01 June...Plan de seguridad para la triple frontera,” Ser en el 2000 Online Database, 01 June 1998. 64 Robert Devlin, Antoni Estevadeordal

  17. Gaudi and reinforced concrete in construction

    OpenAIRE

    Grima Lopez, Rosa; Aguado de Cea, Antonio; Gómez Serrano, José

    2013-01-01

    The first two decades of the 20th century witnessed the introduction and expansion of reinforced concrete as a building material in Spain. Few years passed between the introduction of the first patents in the most industrialized areas of the Iberian Peninsula and the subsequent generalization of the technique through scientific knowledge obtained in universities. This period coincides almost completely with the professional career of Antoni Gaudí, one of the most famous Catalan architects. Th...

  18. Mark Antony’s Homoeroticism in Cicero’s second Philippic

    Directory of Open Access Journals (Sweden)

    Bruna Fernanda Abreu

    2017-06-01

    Full Text Available Considering the concept of homosexuality in the ancient Rome, we attempt to analise how Cicero expose the Mark Antony’s “homosexuality” in his second Philippic. This speech is characterized by political and, mainly, personal accusations from Cicero to Mark Antony, and the Mark Antony’s passivity in his intercourses can be considered a topos of this invective speech.

  19. Gordon Research Conference on Chronobiology

    Science.gov (United States)

    1993-11-01

    AMHERST MA 01002 DR ANTONI DIEZ-NOGUERA OFF UNIVERSITY OF BARCELONA 3434907869 LABORATORY DE FISIOLOGIA ATTENDEE FACULTAT 03 FARMACIA, AV JOAN XXIII SIN...WALTHAM MA 02254 DR BEATRIZ FUENTES-PARDO P 303 UNIV. NACIONAL AUTONOMA DE MEXICO 525-623-2362 DEPARTAMENTO DE FISIOLOGIA , FAC. DE KED. ATTENDEE APDO...Vilaplana, T.Cambras (Laboratori de Fisiologia , Facultat de Farmacia, Universitat de Barcelona): Effects of period length of light/dark cycles in the

  20. ARCHITECTURE DEGREE PROJECT: USE OF 3D TECHNOLOGY, MODELS AND AUGMENTED REALITY EXPERIENCE WITH VISUALLY IMPAIRED USERS

    Directory of Open Access Journals (Sweden)

    Isidro Navarro Delgado

    2012-04-01

    Full Text Available Web 3.0 technologies provide effective tools for interpreting architecture and culture in general. Thus, a project may have an emotional impact on people while also having a more widespread effect in society as a whole. This project defines a methodology for evaluating accessibility of architecture for people with visual disabilities and the application of this to visiting emblematic buildings such as the Basilica of the Holly Family in Barcelona, designed by the architect, Antoni Gaudí.

  1. Näitused

    Index Scriptorium Estoniae

    1998-01-01

    Galerii Vaal - hispaania kunstniku Antoni T̉piesi näitusmüük, Linnagalerii - ruumi- ja moekunstinäitus "Valge", Rahvusraamatukogu - Õie Küti näitus "Uued ja vanad ehted", Arhitektuurimuuseum (Rotermanni soolaladu) - Arnold Matteuse ja Alvar Aalto loomingu näitus, Raevangla - fotonäitus "Eesti Vabariik 80. 50 aastat peidetud pilte Linnamuuseumist", Kullo galerii - erinevad väljapanekud õpilastelt ja harrastuskunstnikelt

  2. The Event Related Brain Potential as an Index of Information Processing, Cognitive Activity, and Skill Acquisition: A Program of Basic Research.

    Science.gov (United States)

    1985-02-28

    Hillsdale, NJ: Lawrence Erlbaum, 1984. Hirst, W., Spelke, E. S., Reaves, C. C., Charack, G., & Neisser, U. Dividing attention without alternation... divided attention in information processing in tracking. Journal of Experimental Psychology: Human Perception and Performance, 1976, 2, 1-13. Wickens, C... attention demanding can be time- shared perfectly. AlIport, Antonis, and Reynolds (1972), for example, asked skilled pianists to shadow verbal

  3. From Editor

    OpenAIRE

    Ugur Demiray

    2013-01-01

    Dear TOJDE Readers, Welcome to the Volume 14 Number: 3 of TOJDE! In this issue, 17 articles of 28 authors from 9 different countries around the world have been published. These published articles are arrived to the TOJDE from, Greece, India, Iran, Malaysia, Pakistan, Thailand, Turkey and USA. The 1st article is arrived from Greece and written by Evangelia MANOUSOU, Tutor-Counselor and Antonis LIONARAKIS. Their article deals with a documented research in order to create a ped...

  4. The Effects of Workload Presented via Visual and Auditory Displays on Soldier Shooting and Secondary Task Performance

    Science.gov (United States)

    2007-08-01

    Cognitive Psychology: New Directions (pp. 112-153). London: Routledge & Kegan Paul, 1980. Allport, D. A.; Antonis, B.; Reynolds, P. On the Division of...live-fire range. The target type presentations will be an enemy targets which will consist of equal sized solid green silhouettes. Friendly targets...will consist of the solid green silhouette with a gray 6-inch disk at the center-of-mass, or a solid brown silhouette. The target exposure times will

  5. 156 Economic Evaluation of Grass Tablets for Immunotherapy (oralair) Compared to Placebo in Adults and Children in Italy

    OpenAIRE

    Cicchetti, Amerigo; Ruggeri, Matteo; Fiocchi, Alessandro; Bonini, Sergio; Puccinelli, Paola; Passalacqua, Giovanni; Frati, Franco

    2012-01-01

    Background Specific immunotherapy is based on the regular administration over time of a maintenance dose of allergen extracts to allergic patients in order to modify the immune response, thus achieving a decrease in symptoms/drug intake and an improvement in quality of life, possibly on the long-term. Grass pollen tablet, Oralair (Stallergenes, Antony Cedex, France), were developed and registered for rhinoconjunctivitis allergy induced by grass pollen. There is sufficient evidence for the cli...

  6. The Biomechanical Role of Scaffolds in Augmented Rotator Cuff Tendon Repairs

    Science.gov (United States)

    2012-01-01

    The biomechanical role of scaffolds in augmented rotator cuff tendon repairs Amit Aurora, D Enga,b, Jesse A. McCarron, MDc, Antonie J. van den Bogert...used for rotator cuff repair augmentation; however, the appropriate scaffold material properties and/or surgical application techniques for achieving...The model predicts that the biomechanical performance of a rotator cuff repair can be modestly increased by augmenting the repair with a scaffold that

  7. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Superconducting linear accelerator system for NSC · P N Prakash T S Datta B P Ajith Kumar J Antony P Barua J Chacko A Choudhury G K Chadhari S Ghosh S Kar S A Krishnan Manoj Kumar Rajesh Kumar A Mandal D S Mathuria R S Meena R Mehta K K Mistri A Pandey M V Suresh Babu B K Sahu A Sarkar S S K Sonti A ...

  8. Rovesciamento e alterazione nei racconti Uranio, Vanadio e in Auschwitz, Città Tranquilla

    Directory of Open Access Journals (Sweden)

    Fausto Maria Greco

    2016-11-01

    Full Text Available Ne Il sistema periodico accade che i processi dell’alterazione e del rovesciamento investano le funzioni stesse della narrazione e della testimonianza. In Uranio il personaggio di Bonino, narratore inattendibile, è un doppio rovesciato di Primo Levi. Egli realizza uno degli incubi dello scrittore torinese, quello di raccontare l’esperienza vissuta nel lager e di non essere creduto, ma l’effetto di rovesciamento riguarda anche altri versanti della scrittura. Come Elie Wiesel nel racconto intitolato Barbara, incluso nella raccolta de L’ebreo errante del 1966, Levi prende le distanze, in Uranio, da una memoria che falsifica, che oltrepassa la barriera della verità per costruire un’immagine eroica dei sopravvissuti. Nell’opera di Levi le figure di doppi rovesciati segnalano rischi incombenti, ipotesi inquietanti; i processi di alterazione, invece, si adattano meglio allo sforzo di conoscenza che riguarda l’universo concentrazionario. In questo rapporto stanno il Bonino di Uranio e il Cerrato di Argento, il dottor Müller di Vanadio (ancora ne Il sistema periodico e l’ingegner Mertens del racconto di Auschwitz, città tranquilla (pubblicato nell’84 e aggiunto ai Racconti e saggi. Dietro i nomi di Müller e di Mertens si celano, però, figure in carne e ossa con le quali lo scrittore è entrato in contatto. Il capovolgimento rivela un’ipotesi provocatoria, una vertigine del pensiero, nel caso di Mertens; l’alterazione apre alla conoscenza etica nella vicenda di Müller.The study focuses on the methods of alteration and overturning that influence functions of narration and testimony in Primo Levi’s Il sistema periodico (1975. In the short story Uranio, the character of Bonino is an unreliable storyteller as well as an overturned double of the writer. Bonino represents one of Levi’s obsessions, i.e., not being believed when telling the experience of prison and extermination camps. The effect of overturning also regards

  9. Proposta de uma abordagem psicoeducacional em grupos para pacientes adultos com Transtorno de Déficit de Atenção/Hiperatividade Propuesta de un abordaje psico-educacional en grupos para pacientes adultos con trastorno de déficit de Atención/ Hiperactividad A psychoeducacional approach in group therapy for adult patients with Attention Deficit/Hyperactivity Disorder

    Directory of Open Access Journals (Sweden)

    Eugenio Horácio Grevet

    2003-12-01

    Full Text Available Os autores do presente artigo propõem, a partir do modelo pedagógico proposto por Antoni Zabala, uma abordagem psicoeducativa grupal para pacientes adultos portadores de Transtorno de Déficit de Atenção/Hiperatividade. Para tanto, adaptam esta estrutura pedagógica para fundamentar a abordagem de grupos psicoeducacionais. O presente trabalho adiciona uma nova técnica para o tratamento do TDAH no adulto a partir da interface entre a pedagogia e a psicoterapia.Los autores del presente artículo proponen, a partir del modelo pedagógico propuesto por Antoni Zabala, un abordaje psico-educativo grupal para pacientes adultos portadores del Tratamiento del Déficit de Atención/Hiperactividad. Para tanto, adaptan esta estructura pedagógica para fundamentar el abordaje de grupos psico-educacionales. El presente trabajo adiciona una nueva técnica para el tratamiento del TDAH en el adulto a partir de la interfase entre la pedagogía y la psicoterapia.TIn this paper the authors suggest a psycho-educative group approach to adult patients with Attention Deficit/Hyperactivity Disorder (ADHD based on a pedagogic model proposed by Antoni Zabala. This paper intends to present this new technique for the treatment of adults with ADHD. The conceptualization is based on the interface between pedagogy and psychotherapy.

  10. Immunotherapy of metastatic melanoma by reversal of immune suppression

    Energy Technology Data Exchange (ETDEWEB)

    Biggs, M.W.; Eiselein, J.E.

    1997-01-01

    Beginning with the observation that the human enteorvirus, Poliovirus Sabin 1, will lyse human melanoma cells in culture, clinical trials involving two patients with advance melanoma were performed. Parenteral injection of the viable Poliovirus into cutaneous melanoma metastases followed in 24 hours by oral administration of cyclophosphamide. The results of these two trials are described.

  11. 20 CFR Appendix A to Subpart F of... - U.S. Seaports

    Science.gov (United States)

    2010-04-01

    ... Port Costa, CA Port Hueneme, CA Port San Luis, CA Redwood City, CA Richmond, CA Sacramento, CA San... Sabine, TX Texas City, TX South Pacific Range Alameda, CA Antioch, CA Benicia, CA Carlsbad, CA Carpinteria, CA Crockett, CA El Segundo, CA Eureka, CA Estero Bay, CA Gaviota, CA Huntington Beach, CA Long...

  12. Investigation of an outbreak of type 3 wild poliovirus in Cote d'Ivoire ...

    African Journals Online (AJOL)

    adedamla

    three doses of polio vaccine compared to non-polio cases, OR: 16.9 [95% CI: 2.3 – 125.0]. More than 27% ... with only the poliovirus vaccine against the circulating poliovirus, people live in precarious socio-economic conditions ...... Sabin and.

  13. The Path of the Blind Watchmaker: A Model of Evolution

    Science.gov (United States)

    2011-04-06

    our countermeasures. Viruses evolve into new strains such that the antibodies produced due to vaccines are ineffective. Bacteria evolve into new...Maddison, Katja- Sabine Schulz, & Wayne P. Maddison. (2007). The Tree of Life Web Project. Zootaxa, 1668, 19-40. [42] Matt Ridley. (2000). The search for

  14. A novel multiplex poliovirus binding inhibition assay applicable for large serosurveillance and vaccine studies, without the use of live poliovirus.

    NARCIS (Netherlands)

    Schepp, Rutger M; Berbers, Guy A M; Ferreira, José A; Reimerink, Johan H; van der Klis, Fiona R

    2017-01-01

    Large-scale serosurveillance or vaccine studies for poliovirus using the "gold standard" WHO neutralisation test (NT) are very laborious and time consuming. With the polio eradication at hand and with the removal of live attenuated Sabin strains from the oral poliovirus vaccine (OPV), starting with

  15. High Dose Atorvastatin Decreases Cellular Markers of Immune Activation Without Affecting HIV-1 RNA Levels: Results of a Double-Blind Randomized Placebo Controlled Clinical Trial

    Science.gov (United States)

    2011-02-15

    allow for seasonal influenza vaccination . Study follow-up ended 4 weeks after completion of both phases. Randomization and Blinding Both placebo and drug...Reiss P, Sabin CA, et al. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007; 356:1723–35. 4. Pike LJ. Rafts defined

  16. New Strains Intended for the Production of Inactivated Polio Vaccine at Low-Containment After Eradication.

    Directory of Open Access Journals (Sweden)

    Sarah Knowlson

    2015-12-01

    Full Text Available Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly virulent poliovirus, and release from a production facility after eradication could be disastrous; WHO have therefore recommended the use of the attenuated Sabin strains for production as a safer option although it is recognised that they can revert to a transmissible paralytic form. We have exploited the understanding of the molecular virology of the Sabin vaccine strains to design viruses that are extremely genetically stable and hyperattenuated. The viruses are based on the type 3 Sabin vaccine strain and have been genetically modified in domain V of the 5' non-coding region by changing base pairs to produce a cassette into which capsid regions of other serotypes have been introduced. The viruses give satisfactory yields of antigenically and immunogenically correct viruses in culture, are without measurable neurovirulence and fail to infect non-human primates under conditions where the Sabin strains will do so.

  17. Would an Influenza Pandemic Qualify as a Major Disaster Under the Stafford Act?

    Science.gov (United States)

    2009-12-15

    Officials Say Swine Flu Vaccine is Coming, CQ HOMELAND SECURITY, July 9, 2009 (quoting DHS Secretary Janet Napolitano as observing that “the [Stafford...not ready for avian flu outbreak, KANSAS CITY STAR, Dec. 13, 2005, at 1; Sabin Russell, Statewide flu plan ready for public input, SAN FRANCISCO

  18. New Strains Intended for the Production of Inactivated Polio Vaccine at Low-Containment After Eradication.

    Science.gov (United States)

    Knowlson, Sarah; Burlison, John; Giles, Elaine; Fox, Helen; Macadam, Andrew J; Minor, Philip D

    2015-12-01

    Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly virulent poliovirus, and release from a production facility after eradication could be disastrous; WHO have therefore recommended the use of the attenuated Sabin strains for production as a safer option although it is recognised that they can revert to a transmissible paralytic form. We have exploited the understanding of the molecular virology of the Sabin vaccine strains to design viruses that are extremely genetically stable and hyperattenuated. The viruses are based on the type 3 Sabin vaccine strain and have been genetically modified in domain V of the 5' non-coding region by changing base pairs to produce a cassette into which capsid regions of other serotypes have been introduced. The viruses give satisfactory yields of antigenically and immunogenically correct viruses in culture, are without measurable neurovirulence and fail to infect non-human primates under conditions where the Sabin strains will do so.

  19. PER.C6(®) cells as a serum-free suspension cell platform for the production of high titer poliovirus: a potential low cost of goods option for world supply of inactivated poliovirus vaccine

    NARCIS (Netherlands)

    Sanders, Barbara P.; Edo-Matas, Diana; Custers, Jerome H. H. V.; Koldijk, Martin H.; Klaren, Vincent; Turk, Marije; Luitjens, Alfred; Bakker, Wilfried A. M.; Uytdehaag, Fons; Goudsmit, Jaap; Lewis, John A.; Schuitemaker, Hanneke

    2013-01-01

    There are two highly efficacious poliovirus vaccines: Sabin's live-attenuated oral polio vaccine (OPV) and Salk's inactivated polio vaccine (IPV). OPV can be made at low costs per dose and is easily administrated. However, the major drawback is the frequent reversion of the OPV vaccine strains to

  20. Using Knowledge about the Opponent in Game-Tree Search.

    Science.gov (United States)

    1992-09-01

    Schaeffer’s stimulating enthusiasm and dynamism spurred me on when I seemed to be stuck in perpetual check. Though I interacted with Jaime Carbonell...and Gene, Pierre, Fang and XiaoGang, Sabine and Consuelo. To them, and all the others I had to omit here, my sincere thanks. Finally, all of this

  1. The Use of Autonomous Vehicles for Spatially Measuring Mean Velocity Profiles in Rivers and Estuaries

    Science.gov (United States)

    2011-09-01

    Advisor: Jaime MacMahan Second Reader: Ed Thornton THIS PAGE INTENTIONALLY LEFT BLANK i REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188...Currents. IEEE J. Ocean. Eng. 26(4), 752–768. Eriksen, C. C., Osse, T. J., Light, R. D., Wen, T., Lehman, T. W., Sabin , P. L., Ballard, J. W., Chiodi

  2. World Epidemiology Review No. 77.

    Science.gov (United States)

    1976-12-09

    3 years of age because they were not vacci- nated at the proper time. The ministry supplies the Sabin oral vaccine without cost to children between...in Balsas Parish of Pinas Canton in the early part of September. The sanitary operation was under the close supervision of Dr Jaime Vivero, chief

  3. Efficient Training Methods for Conditional Random Fields

    Science.gov (United States)

    2008-02-01

    Learning (ICML), 2007. [63] Bruce G. Lindsay. Composite likelihood methods. Contemporary Mathematics, pages 221–239, 1988. 189 [64] Yan Liu, Jaime ...Conference on Machine Learning (ICML), pages 737–744, 2005. [107] Erik F. Tjong Kim Sang and Sabine Buchholz. Introduction to the CoNLL-2000 shared task

  4. U.S. Army War College Guide to Strategy

    Science.gov (United States)

    2001-02-01

    Stanford University Press, 1993. 26. Rudolf Hrbek and Sabine Wegand, Betrifft! Europa der Regionen, Berlin: C.H. Beck, 1994. 27. John Mueller...Barracks: U.S. Army War College, November 1998. Navarro, Jaime . Joint Vision 2010: Naval Warfare Imperatives. Newport: U.S. Naval War College

  5. The Coast Artillery Journal. Volume 66, Number 6, June 1927

    Science.gov (United States)

    1927-06-01

    of the Paris and the Jaime I inflicted little damage on the Riffian works, failed to demoralize the defenders, and, had not Abdel-Krim scattered his...researches of Sabine and Watson. Not tbe least important part of the book is the bibliographical data, which are carefully indexed under many subjects

  6. Competence for Democracy: Participation and Decision-Making in Classroom Interaction

    Science.gov (United States)

    Manzel, Sabine

    2016-01-01

    In this keynote address given at the International Association for Citizenship, Social and Economics Education (IACSEE) Conference in July 2015, Sabine Manzel focused on participation and decision-making as key competences for democracy. She analysed with standardized videography how both of these competences are realized in classroom interaction.

  7. Oyster Shell Dredging in Gulf of Mexico Waters, St. Mary and Terrebonne Parishes, Louisiana. Final Environmental Impact Statement and Appendixes

    Science.gov (United States)

    1994-04-01

    sabinae Sabine shiner x Notropis texanus weed shiner x Notropis volucellus mimic shiner X Ogeocephalus radiatus polka-dot bat fish x Oligoplites saurus ...Elope saurus ladyfish x x Erimyzon oblongus creek chubsucker x Esox americanus vermiculatus grass pickerel x Etheostoma chiorosomum, bluntnose darter

  8. "Ekspeditsioon Wunderlich" = "Expedition Wunderlich" / Carl-Dag Lige, Hannes Praks ; kommenteerinud Triin Ojari

    Index Scriptorium Estoniae

    Lige, Carl-Dag, 1982-

    2016-01-01

    Näitus "Ekspeditsioon Wunderlich" Eesti Arhitektuurimuuseumis. Autorid Katrin Talvik, Merilin Tee, Sabine Suuster, Martin Saar, Karl Taul, Alden Jõgisuu, Tõnu Lensment, Aadam Kaarma, Cael-Dag Lige, Hannes Praks. Näitus on Eesti Kunstiakadeemia ja Eesti Arhitektuurimuuseumi ühisprojekt

  9. Different virucidal activities of hyperbranched quaternary ammonium coatings on poliovirus and influenza virus

    NARCIS (Netherlands)

    Tuladhar, E.; Koning, de M.C.; Fundeanu, I.; Beumer, R.R.; Duizer, E.

    2012-01-01

    Virucidal activity of immobilized quaternary ammonium compounds (IQACs) coated onto glass and plastic surfaces was tested against enveloped influenza A (H1N1) virus and nonenveloped poliovirus Sabin1. The IQACs tested were virucidal against the influenza virus within 2 min, but no virucidal effect

  10. of southern Africa

    African Journals Online (AJOL)

    1995-02-15

    Feb 15, 1995 ... tory, with fossils dating from thc Middle Eocene (Auffenberg. 1974), and an .... A fuller analysis of the situation has not been published, and the. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by th e P u blish er (dated 2009). ...... Hunter-gatherer-fishers of the Fish River Basin: A. R eprodu.

  11. Chopper GEN2 + Glyphosate efficacy for height classes of hardwood sprouts recolonizing six clearcut pine sites

    Science.gov (United States)

    Jimmie Yeiser; Andrew Ezell

    2015-01-01

    The purpose of this study was to assess sprout size as a determinant of subsequent control by a standard, single rate of imazapyr +glyphosate applied during site preparation. All study sites were in the hilly upper coastal plain of Mississippi (Winston or Oktibbeha Counties) or Louisiana (Sabine or Winn Parishes) and supported loblolly pine (Pinus taeda L.) plantations...

  12. Ai~O~;::({{'~~:~1i~~ri~~jf~~',i~a!i~~~~~fJit!E~f~~7

    African Journals Online (AJOL)

    by Sabin et G atew ay u n d er licen ce gran ted by th e P u blish er (d ated ... cattle as dip wash/pour-oli or applied on screens ",,:Production of surplus male tsetse .... larva whereas those mated by sterile males show a confirm the presence or ...

  13. SET-Routes programme

    CERN Multimedia

    Marietta Schupp, EMBL Photolab

    2008-01-01

    Dr Sabine Hentze, specialist in human genetics, giving an Insight Lecture entitled "Human Genetics – Diagnostics, Indications and Ethical Issues" on 23 September 2008 at EMBL Heidelberg. Activities in a achool in Budapest during a visit of Angela Bekesi, Ambassadors for the SET-Routes programme.

  14. Through the Eyes of an Infant : The Early Development of Visual Scanning and Disengagement of Attention

    NARCIS (Netherlands)

    Hunnius, S.

    2005-01-01

    Sabine Hunnius bestudeerde de ontwikkeling van het kijkgedrag van baby's tussen de zes weken en zes maanden. Het kijkgedrag van een jonge baby onderscheidt zich sterk van dat van een volwassene. Zeer jonge baby’s kijken al wel naar dingen die zich binnen hun blikveld bevinden, hierbij komen echter

  15. Experimental Validation of the Reverberation Effect in Room Electromagnetics

    DEFF Research Database (Denmark)

    Steinböck, Gerhard; Pedersen, Troels; Fleury, Bernard Henri

    2015-01-01

    . This tail can be characterized with Sabine's or Eyring's reverberation models, which were initially developed in acoustics. So far, these models were only fitted to data collected from radio measurements, but no thorough validation of their prediction ability in electromagnetics has been performed yet...

  16. Geological remote sensing

    Science.gov (United States)

    Bishop, Charlotte; Rivard, Benoit; de Souza Filho, Carlos; van der Meer, Freek

    2018-02-01

    Geology is defined as the 'study of the planet Earth - the materials of which it is made, the processes that act on these materials, the products formed, and the history of the planet and its life forms since its origin' (Bates and Jackson, 1976). Remote sensing has seen a number of variable definitions such as those by Sabins and Lillesand and Kiefer in their respective textbooks (Sabins, 1996; Lillesand and Kiefer, 2000). Floyd Sabins (Sabins, 1996) defined it as 'the science of acquiring, processing and interpreting images that record the interaction between electromagnetic energy and matter' while Lillesand and Kiefer (Lillesand and Kiefer, 2000) defined it as 'the science and art of obtaining information about an object, area, or phenomenon through the analysis of data acquired by a device that is not in contact with the object, area, or phenomenon under investigation'. Thus Geological Remote Sensing can be considered the study of, not just Earth given the breadth of work undertaken in planetary science, geological features and surfaces and their interaction with the electromagnetic spectrum using technology that is not in direct contact with the features of interest.

  17. The use of a reference absorber for absorption measurements in a reverberation chamber

    DEFF Research Database (Denmark)

    Nolan, Melanie; Vercammen, Martijn; Jeong, Cheol-Ho

    2014-01-01

    The statistical incidence absorption coefficient is measured in a reverberation room according to ISO 354. This absorption coefficient is referred to as Sabine absorption coefficient, which assumes the chambe r to be completely diffuse. It is known that the reproducibility of these results is poo...

  18. Effects of different diffuser types on the diffusivity in reverberation chambers

    DEFF Research Database (Denmark)

    Nolan, Melanie; Vercammen, Martijn; Jeong, Cheol-Ho

    2015-01-01

    Knowledge of sound absorption properties of typical building materials is essential for all tasks related to room acoustic design. The Sabine absorption coefficient is measured in a reverberation chamber according to the international standard ISO 354. It is known that inter-laboratory reproducib...

  19. 77 FR 25711 - Cheniere Marketing, LLC; Application for Blanket Authorization To Export Previously Imported...

    Science.gov (United States)

    2012-05-01

    ... Sabine Pass LNG, L.P., in Cameron Parish, Louisiana, to any country with the capacity to import LNG via... imported from foreign sources to any country with the capacity to import LNG via ocean-going carrier and... the domestic natural gas market contingent on U.S. and global market price signals. CMI states that no...

  20. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Sunanda Banerjee Rohini M Godbole Sreerup Raychaudhuri Ben Allanach Sunanda Banerjee Satyaki Bhattacharyya Debajyoti Choudhury Siba Prasad Das Anindya Datta Rohini M Godbole Monoranjan Guchait Sabine Kraml Gobinda Majumdar David Miller Margarete Mühlleitner Nobuchika Okada Maxim Perelstein ...

  1. Monoranjan Guchait

    Indian Academy of Sciences (India)

    Sunanda Banerjee Rohini M Godbole Sreerup Raychaudhuri Ben Allanach Sunanda Banerjee Satyaki Bhattacharyya Debajyoti Choudhury Siba Prasad Das Anindya Datta Rohini M Godbole Monoranjan Guchait Sabine Kraml Gobinda Majumdar David Miller Margarete Mühlleitner Nobuchika Okada Maxim Perelstein ...

  2. The proposed transfer of the echiuran Ochetostoma capense to the ...

    African Journals Online (AJOL)

    1988-08-22

    Aug 22, 1988 ... 430-431; Day, 1974: 50; Mathew, 1976: 151-158. R eprod u ced by Sabin et G atew ay u n ... through different shades of cream-yellow, to light orange. ... Colour of trunk variable, ranging from dark grey-brown to purple-brown.

  3. BLINDAGE: A neutron and gamma-ray transport code for shieldings with the removal-diffusion technique coupled with the point-kernel technique

    International Nuclear Information System (INIS)

    Fanaro, L.C.C.B.

    1984-01-01

    It was developed the BLINDAGE computer code for the radiation transport (neutrons and gammas) calculation. The code uses the removal - diffusion method for neutron transport and point-kernel technique with buil-up factors for gamma-rays. The results obtained through BLINDAGE code are compared with those obtained with the ANISN and SABINE computer codes. (Author) [pt

  4. Zoogeography of the southern African echinoderm fauna

    African Journals Online (AJOL)

    1988-04-17

    Apr 17, 1988 ... Pertinent features of the oceanography of southern Africa are reviewed and an analysis of the echinoderm fauna in relation to the genera] ..... five extant echinoderm classes (all species). Crinoids. Asteroids Ophiuroids .... Australia and New Zealand, which are included with. R eprod u ced by Sabin et G.

  5. Siinushelidest kosmilise muusikani / Gerhard Lock

    Index Scriptorium Estoniae

    Lock, Gerhard, 1978-

    2007-01-01

    Saksa heliloojast Karlheinz Stockhausenist. Festivalil "Klaver 2006" kõlas 24. oktoobril 2006. a. Eesti Muusika- ja Teatriakadeemia kammersaalis Eestis esmakordselt Karlheinz Stockhauseni suurteos "Mantra" kahele klaverile ja elektroonikale. Esitajateks Kadri-Ann Sumera ja Sabine Simon, helirežisöör Hendrik Manook

  6. A Postcolonial reading of Mural Art in South Africa | Marschall ...

    African Journals Online (AJOL)

    A Postcolonial reading of Mural Art in South Africa. Sabine Marschall. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals ...

  7. Effects of Mulch and Cultivar on Strawberry Productivity under ...

    African Journals Online (AJOL)

    planted at the beginning of long rains in March 2002. Data were recorded from the fourth month after planting .... each plant, putting all leaves per treatment in a. R eprod u ced by Sabin et G atew ..... Indian Society of Soil Science 41: 17-25.

  8. Suur müüdikonverents Tartus / Evelin Banhard

    Index Scriptorium Estoniae

    Banhard, Evelin

    2008-01-01

    Tartus toimunud rahvusvahelisest konverentsist "Suurte kultuuriliste ja kirjanduslike müütide saatus tänapäeval". Pikemalt Liisa Saariluoma, Jüri Talveti, Angelika Stefanova, Tanel Lepsoo, Caroline De Wagteri, Sonia Bravo Utrera, Ana Martinoska, Marin Laagi, Rutt Hinrikuse, Jeanne Elisabeth Gleseneri, Sabine Coelsch-Foisneri, Harvey L. Hixi ja Hannu K. Riikoneni ettekannetest

  9. Listening in Circles: Spoken Drama and the Architects of Sound, 1750-1830

    NARCIS (Netherlands)

    Tkaczyk, V.

    2014-01-01

    The establishment of the discipline of architectural acoustics is generally attributed to the physicist Wallace Clement Sabine, who developed the formula for reverberation time around 1900, and with it the possibility of making calculated prognoses about the acoustic potential of a particular

  10. variation of reverberation time with quantity of absorbers in an ...

    African Journals Online (AJOL)

    DJFLEX

    broadcasting and recording studios, reverberation time can be simply controlled to achieve desired results. KEY WORDS: ..... Positions and Actual sizes and Numbers of. Absorbers Used. Measured. Reverberation. Times (s). Calculated with. Sabine Formula. Calculated with. Arau-Puchades. Formula. 500. (Hz). 1000. (Hz).

  11. Patterns of distribution and protection status of the endemic ...

    African Journals Online (AJOL)

    1995-06-02

    Jun 2, 1995 ... South Africa contains the majority of southern Africa's endemic mammals and hence is an important ... example of an archaic fauna that has undergone local radia- ... Indeed, only six of South Africa's endemic. R eprodu ced by Sabin et G atew ..... of the endemic flora of this region is renowned (Cowling,.

  12. Managing conflict over biological control: the case of strawberry guava in Hawaii

    Science.gov (United States)

    Tracy Johnson

    2016-01-01

    Biological control researchers commonly avoid targets with potential for high conflict, but for certain highly damaging invaders with no viable management alternatives, it may be necessary to consider biological control even when it is likely to generate conflict. Discussed here is a case study, strawberry guava (Psidium cattleianum Sabine...

  13. 76 FR 48777 - Endangered and Threatened Wildlife and Plants; 12-Month Finding on a Petition To List the Nueces...

    Science.gov (United States)

    2011-08-09

    ... occurs within the range of the species, we could find no information on the extent or intensity of..., disturbance and erosion from trampled banks, and increased solar exposure due to reduced shade from streamside... stream flow measurements in the Frio, Sabinal, and Nueces Rivers for the last decade. Results of Edward's...

  14. mica – music information center austria

    OpenAIRE

    2010-01-01

    1994 wurde das österreichische Musikinformationszentrum (mica) im Auftrag des österreichischen Bundesministers für Unterricht und Kunst (Rudolf Scholten) von den Bundeskuratoren für Musik (L. Knessl, Christian Scheib) gegründet (Geschäftsführer 1994–99 Matthias Finkentey, 1999–09 Peter Rantasa, ab 2009 Sabine Reiter).

  15. Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region.

    Science.gov (United States)

    Zhang, Yong; Zhu, Shuangli; Yan, Dongmei; Liu, Guiyan; Bai, Ruyin; Wang, Dongyan; Chen, Li; Zhu, Hui; An, Hongqiu; Kew, Olen; Xu, Wenbo

    2010-12-21

    Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008. Complete genomic sequences revealed their vaccine-related genomic features and showed that their first crossover sites were randomly distributed in the 3' end of the VP1 coding region. The length of donor Sabin 2 sequences ranged from 55 to 136 nucleotides, which is the longest donor sequence reported in the literature for this type of poliovirus recombination. The recombination resulted in the introduction of Sabin 2 neutralizing antigenic site 3a (NAg3a) into a Sabin 3 genomic background in the VP1 coding region, which may have been altered by some of the type 3-specific antigenic properties, but had not acquired any type 2-specific characterizations. NAg3a of the Sabin 3 strain seems atypical; other wild-type poliovirus isolates that have circulated in recent years have sequences of NAg3a more like the Sabin 2 strain. 10 natural type 3/type 2 intertypic VP1 capsid-recombinant polioviruses, in which the first crossover sites were found to be in the VP1 coding region, were isolated and characterized. In spite of the complete replacement of NAg3a by type 2-specific amino acids, the serotypes of the recombinants were not altered, and they were totally neutralized by polyclonal type 3 antisera but not at all by type 2 antisera. It is possible that recent type 3 wild poliovirus isolates may be a recombinant having NAg3a sequences derived from another strain during between 1967 and 1980, and the type 3/type 2 recombination events in the 3' end of the VP1 coding region may result in a higher fitness.

  16. Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region.

    Directory of Open Access Journals (Sweden)

    Yong Zhang

    Full Text Available BACKGROUND: Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008. PRINCIPAL FINDINGS: Complete genomic sequences revealed their vaccine-related genomic features and showed that their first crossover sites were randomly distributed in the 3' end of the VP1 coding region. The length of donor Sabin 2 sequences ranged from 55 to 136 nucleotides, which is the longest donor sequence reported in the literature for this type of poliovirus recombination. The recombination resulted in the introduction of Sabin 2 neutralizing antigenic site 3a (NAg3a into a Sabin 3 genomic background in the VP1 coding region, which may have been altered by some of the type 3-specific antigenic properties, but had not acquired any type 2-specific characterizations. NAg3a of the Sabin 3 strain seems atypical; other wild-type poliovirus isolates that have circulated in recent years have sequences of NAg3a more like the Sabin 2 strain. CONCLUSIONS: 10 natural type 3/type 2 intertypic VP1 capsid-recombinant polioviruses, in which the first crossover sites were found to be in the VP1 coding region, were isolated and characterized. In spite of the complete replacement of NAg3a by type 2-specific amino acids, the serotypes of the recombinants were not altered, and they were totally neutralized by polyclonal type 3 antisera but not at all by type 2 antisera. It is possible that recent type 3 wild poliovirus isolates may be a recombinant having NAg3a sequences derived from another strain during between 1967 and 1980, and the type 3/type 2 recombination events in the 3' end of the VP1 coding region may result in a higher fitness.

  17. Environmental Surveillance of Polioviruses in Rio de Janeiro, Brazil, in Support to the Activities of Global Polio Eradication Initiative.

    Science.gov (United States)

    de Oliveira Pereira, Joseane Simone; da Silva, Lidiane Rodrigues; de Meireles Nunes, Amanda; de Souza Oliveira, Silas; da Costa, Eliane Veiga; da Silva, Edson Elias

    2016-03-01

    Wild polioviruses still remain endemic in three countries (Afghanistan, Pakistan, and Nigeria) and re-emergency of wild polio has been reported in previously polio-free countries. Environmental surveillance has been used as a supplementary tool in monitoring the circulation of wild poliovirus (PVs) and/or vaccine-derived PVs even in the absence of acute flaccid paralysis cases. This study aimed to monitor the presence of polioviruses in wastewater samples collected at one wastewater treatment plant located in the municipality of Rio de Janeiro, Brazil. From December 2011 to June 2012 and from September to December 2012, 31 samples were collected and processed. RD and L20B cell cultures were able to isolate PVs and non-polio enteroviruses in 27/31 samples. Polioviruses were isolated in eight samples (type 1 Sabin = 1, type 2 Sabin = 5, and type 3 Sabin = 2). Vaccine-derived polioviruses were not detected nor evidence of recombination with other PVs or non-polio enterovirus serotypes were observed among the isolates. The Sabin-related serotypes 2 and 3 presented nucleotide substitutions in positions associated with the neurovirulent phenotype at the 5'-UTR. Changes in important Amino acid residues at VP1 were also observed in the serotypes 2 and 3. Environmental surveillance has been used successfully in monitoring the circulation of PVs and non-polio enteroviruses and it is of crucial importance in the final stages of the WHO global polio eradication initiative. Our results show the continuous circulation of Sabin-like PVs and non-polio enteroviruses in the analyzed area during the study period.

  18. Foundations of commutative rings and their modules

    CERN Document Server

    Wang, Fanggui

    2016-01-01

    This book provides an introduction to the basics and recent developments of commutative algebra. A glance at the contents of the first five chapters shows that the topics covered are ones that usually are included in any commutative algebra text. However, the contents of this book differ significantly from most commutative algebra texts: namely, its treatment of the Dedekind–Mertens formula, the (small) finitistic dimension of a ring, Gorenstein rings, valuation overrings and the valuative dimension, and Nagata rings. Going further, Chapter 6 presents w-modules over commutative rings as they can be most commonly used by torsion theory and multiplicative ideal theory. Chapter 7 deals with multiplicative ideal theory over integral domains. Chapter 8 collects various results of the pullbacks, especially Milnor squares and D+M constructions, which are probably the most important example-generating machines. In Chapter 9, coherent rings with finite weak global dimensions are probed, and the local ring of weak gl...

  19. Introduction to game theory

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The basic ideas of game theory were originated from the problems of maximum and minimum given by J.Yon Neumann in 1928. Later, wars accelerated the study of game theory, there are many developments that contributed to the advancement of game theory, many problems of optimum appeared in economic development process. Scientists applied mathematic methods to studying game theory to make the theory more profound and perfect. The axiomatic structure of game theory was nearly complete in 1944. The path of the development of game theory started from finite to infinite, from two players to many players, from expressing gains with quantity to showing the ending of game theory with abstract result, and from certainty problems to random problems. Thus development of game theory is closely related to the economic development. In recent years, the research on the non-differentiability of Shapley value posed by Belgian Mertens is one of the advanced studies in game theory.

  20. Self-Regulation and the Effects of an Educational Intervention in Secondary Education

    Directory of Open Access Journals (Sweden)

    Rosa María Osés Bargas

    2014-04-01

    Full Text Available The purpose of this paper was to foster the first grade students’ self-regulatory learning skills in a public elemental secondary school through an educational intervention program that allows them to acquire effective study skills to improve academic performance. The whole population of first grade (226 classified into six classrooms labeled from A to F was participated. The Flores and Cerino (2000 Self-regulation Questionnaire was used. It was an applied research with a time series design with static groups (Mertens, 2005. The outcomes show that the educational intervention program had an impact only on support and meta-cognitive factors in classroom A, and on the cognitive factor in classrooms A and D. In conclusion, it is important to point out the professors’ meaningful role in teaching these processes as well as the use of other methods to assess the development of the sel-regulation processes.

  1. Data from a targeted proteomics approach to discover biomarkers in saliva for the clinical diagnosis of periodontitis

    Directory of Open Access Journals (Sweden)

    V. Orti

    2018-06-01

    Full Text Available This study focused on the search for new biomarkers based on liquid chromatography-multiple reaction monitoring (LC-MRM proteomics profiling of whole saliva from patients with periodontitis compared to healthy subjects. The LC-MRM profiling approach is a new and innovative method that has already been validated for the absolute and multiplexed quantification of biomarkers in several diseases. The dataset for this study was produced using LC-MRM to monitor protein levels in a multiplex assay, it provides clinical information on salivary biomarkers of periodontitis. The data presented here is an extension of our recently published research article (Mertens et al., 2017 [1]. Keywords: Clinical chemistry, Mass spectrometry, Proteomics, Saliva biochemistry, Oral disease, Periodontitis

  2. Decrease in artificial tanning by French teenagers: 2011-2016.

    Science.gov (United States)

    Say, Matthieu; Beauchet, Alain; Vouldoukis, Ioannis; Beauchet, Pascale; Boudet, Monique; Tella, Emilie; Mahé, Emmanuel

    2018-03-13

    The major risk factor for skin cancers is exposure to solar and artificial ultraviolet radiation, in particular during childhood and adolescence. In France, a law was restricted for tanning-bed access to adults (≥18 years) since 1997. To evaluate teenagers' artificial tanning behaviour in 2016 and to compare results with those obtained in a similar survey performed in 2011. The SOLADO 2011 and 2016 surveys were conducted in a general school in Antony and a technical school in Fontenay-aux-Roses (Paris suburb). In 2016, 630 teenagers (mean age: 14.2 ± 1.9 y: Males/Females: 301/329) completed the questionnaire, 1.3% of teenagers reported using tanning beds, 1.1% tanning pills and 8.9% tanning creams. Between 2011 and 2016, the use of tanning beds decreased from 1.4% to 0.7% in Antony (P = .26) and from 9.5% to 4.8% in Fontenay-aux-Roses (P = .01), and the use of tanning creams from 39.8% to 17.6% in Fontenay-aux-Rose (P = .0007). The incidence of sunburn decreased from 60.5% to 54.0% in Antony (P = .02) and from 55.4% to 42.4% in Fontenay-aux-Roses (P = .05). As compared to 2011, teenagers used artificial tanning methods less frequently in 2016. In particular, they used tanning beds less frequently, suggesting that the new stricter legislation has been effective. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Hardronic Festival 2017

    CERN Multimedia

    Caraban Gonzalez, Noemi

    2017-01-01

    More info: http://hardronic.web.cern.ch/Hardronic/2017/ 15:00 Skype Mom 15:30 Anna & Antoni Jazz Dipole 16:15 Let It Beam 17:00 The Nearlies 17:45 Fuzzy Dunlop 18:30 Cover Ops 19:15 Miss Proper and the Moving Targets 20:00 Blue Men Sing the Whites 21:00 Les Horribles Cernettes 22:00 NFB 22:45 Diracula PLUS starting from 0:00, MaNaGe (DJs)

  4. The essential role of mentors in medical institutions

    Directory of Open Access Journals (Sweden)

    Mohamed A

    2016-12-01

    Full Text Available Arez Mohamed, Elena Antoni University College London Medical School, University College London, London, UKWe read with great interest the papers written by Al Qahtani¹ and Banu et al.² The former explored the motivation of medical students to engage in mentoring in a place where this was a scarce phenomenon and the other analyzed how mentoring could be successfully implemented and enhance acquisition of knowledge among mentees.  View original paper by Al QahtaniView original paper by Banu et al 

  5. La difusión de la teoría evolucionista de Lamarck en la revista La Abeja (1862-1870) de Barcelona

    OpenAIRE

    Camós Cabeceran, Agustí

    1997-01-01

    Between 1862 and 1864 Lamarck's works were diffused in Spain through a magazine called La Abeja which was edited by Antoni Bergnes de las Casas, and published in Barcelona. This may reveal a more important influence of Lamarck's theory on the introduction of evolutionary theories in Spain. La Abeja includes the translation of the Histoire naturelle des végétaux where Lamarck incorporated an early explanation of his theory of evolution; ...

  6. A psychoeducacional approach in group therapy for adult patients with Attention Deficit/Hyperactivity Disorder

    OpenAIRE

    Grevet, Eugenio Horácio; Belmonte-de-Abreu, Paulo Silva; Shansis, Flavio Milman

    2003-01-01

    Os autores do presente artigo propõem, a partir do modelo pedagógico proposto por Antoni Zabala, uma abordagem psicoeducativa grupal para pacientes adultos portadores de Transtorno de Déficit de Atenção/Hiperatividade. Para tanto, adaptam esta estrutura pedagógica para fundamentar a abordagem de grupos psicoeducacionais. O presente trabalho adiciona uma nova técnica para o tratamento do TDAH no adulto a partir da interface entre a pedagogia e a psicoterapia.Los autores del presente artículo p...

  7. Proposta de uma abordagem psicoeducacional em grupos para pacientes adultos com Transtorno de Déficit de Atenção/Hiperatividade

    OpenAIRE

    Grevet, Eugenio Horácio; Abreu, Paulo Belmonte de; Shansis, Flávio

    2003-01-01

    Os autores do presente artigo propõem, a partir do modelo pedagógico proposto por Antoni Zabala, uma abordagem psicoeducativa grupal para pacientes adultos portadores de Transtorno de Déficit de Atenção/Hiperatividade. Para tanto, adaptam esta estrutura pedagógica para fundamentar a abordagem de grupos psicoeducacionais. O presente trabalho adiciona uma nova técnica para o tratamento do TDAH no adulto a partir da interface entre a pedagogia e a psicoterapia. TIn this paper the authors sugg...

  8. Estudio espectroscópico de la radiación electromagnética ultravioleta, visible e infrarroja cercana sobre la obra pictórica.

    OpenAIRE

    D'ANTONI, PABLO LUIS

    2013-01-01

    La Tesis "Estudio Espectroscópico de la Radiación Electromagnética, Ultravioleta Visible e Infrarroja cercana sobre la Obra Pictórica" de Pablo D'Antoni desarrolla un método no invasivo para caracterizar, medir y predecir daños a los pigmentos y aglutinantes en obras pictóricas, probablemente por la radiación electromagnética (REM). Usando 3 formas de Espectroscopia: 1) Irradiancia, 2) FORS(Espectroscopía de Reflectancia (y Absorbancia) con Fibra Optica, se analizan los efectos producidos por...

  9. Marite Kallasma - diktorist eetrinägude direktoriks / Tuuli Koch

    Index Scriptorium Estoniae

    Koch, Tuuli

    2008-01-01

    Legendaarne telediktor Marite Kallasma pälvis president Toomas Hendrik Ilveselt Valgetähe V klassi teenetemärgi. Praegu on Marite Kallasma eetrinõustaja ja diktorite õpetaja. Vt. samas: teenetemärgi pälvinud kaitseliitlane Janek Tšeljadinov, USA ajaloolane ja ajakirjanik Anne Applebaum, briti ajaloolane Antony Beevor, Portugali president Anibal Cavaco Silva, briti ajaloolane Norman Davies, Narva sümfooniaorkestri looja Anatoli Štšura, Kallaste vanausuliste koguduse esimees Pavel Varunin, Eesti Entsüklopeediakirjastuse kunstiline toimetaja Maie-Hele Segerkrantz

  10. Neurilemomas de cavidad oral y cuello Neurilemmomas of the oral cavity and the neck

    Directory of Open Access Journals (Sweden)

    J.A. García de Marcos

    2004-12-01

    Full Text Available Los neurilemomas son tumores neurogénicos benignos, con origen en la vaina neural. De los neurilemomas extracraneales, aproximadamente un 25 a un 45% ocurren en cabeza y cuello. La edad de afectación predominante es entre la tercera y la cuarta décadas de vida. El neurilemoma es un tumor claramente circunscrito y, generalmente, de pequeño tamaño. Clínicamente aparece como una masa de crecimiento lento y gradual. El examen microscópico es necesario para el diagnóstico. El tratamiento de elección es la escisión quirúrgica completa tumoral y después de ésta es muy rara su recurrencia. El propósito de este artículo es presentar un estudio retrospectivo, de nueve casos, de neurilemomas de cavidad oral y cuello, tratados en nuestro servicio de Cirugía Oral y Maxilofacial, entre 1997 y 2001. Hemos valorado una serie de parámetros epidemiológicos (edad, sexo, localización, tamaño, clínica, estudios previos a la cirugía, tiempo trascurrido entre aparición de síntomas y primera consulta, nervio de origen, patrón histológico predominante (Antoni A, Antoni B, y evolución postquirúrgica. Se ha realizado una revisión de la literatura.Neurilemomas are benign neurogenic tumours, that derive from the neural sheath. Approximately 25 to 45 per cent of the extracraneal neurilemomas occur in the head and neck region. Neurilemomas usually occur between the third and the fourth decades of life. Neurilemoma is a sharply circumscribed, and usually small tumor. Clinically it manifests as a slow and gradually growing mass; microscopic examination is neccesary for diagnosis. Complete tumoral excision remains the treatment of choice and after this, they rarely recur. The aim of this article is to report a retrospective study, of nine cases, of oral cavity and neck neurilemomas, treated in our service of Oral and Maxillofacial Surgery, between 1997 and 2001. A series of epidemiological parameters (age, sex, location, size, symptoms, preoperative

  11. ¿Quién fue Lluís Montané i Mollfulleda?

    OpenAIRE

    Balius i Juli, Ramon

    2006-01-01

    Lluís Montané i Mollfulleda, nacido en Sant Celoni en 1905, era un artista integral, enmarcado en las corrientes novecentistas y mediterranistas que se sustentan en la tradición clásica del mundo griego. Estudió en la Escuela de Bellas Artes de Barcelona (Llotja) entre 1921 y 1927, aunque antes, muy joven, trabajó durante tres años en el taller del escultor Eusebi Arnau (1864-1933). En la Llotja su segundo maestro, después del profesor de primer curso, Parera, fue Antoni Alsina i Amils (1864-...

  12. Differential manifolds

    CERN Document Server

    Kosinski, Antoni A

    2007-01-01

    The concepts of differential topology form the center of many mathematical disciplines such as differential geometry and Lie group theory. Differential Manifolds presents to advanced undergraduates and graduate students the systematic study of the topological structure of smooth manifolds. Author Antoni A. Kosinski, Professor Emeritus of Mathematics at Rutgers University, offers an accessible approach to both the h-cobordism theorem and the classification of differential structures on spheres.""How useful it is,"" noted the Bulletin of the American Mathematical Society, ""to have a single, sho

  13. El Plan Bonet, 1961-64. La condición del paisaje en la ordenación del desarrollo turístico de La Manga del Mar Menor

    OpenAIRE

    Parra-Martinez, Jose; Moreno Ortolano, Juan; Martínez-Medina, Andrés

    2014-01-01

    En el contexto rural de Murcia, la recepción de la modernidad fue un fenómeno episódico y tardío. Hacia 1960 se produjo, sin embargo, un breve e ilusionante periodo cuando algunos maestros de la arquitectura española llegaron para trabajar en el desarrollo turístico de un litoral virgen y lleno de oportunidades. Entre ellos, Antoni Bonet recibió el encargo de urbanizar La Manga, una estrecha franja de tierra de 24km que separa el Mediterráneo del Mar Menor. El Plan retomaba los planteamientos...

  14. On the flow, thermal field and winds along the western continental shelf of India

    Digital Repository Service at National Institute of Oceanography (India)

    Antony, M.K.; Shenoi, S.S.C.

    drift will be in phase with the density field or in geostrophic balance. The instrusion of the Bay of 438 M.K. ANTONY and S. S. C. SHENOI Bengal water (less dense than the Arabian Sea water) into the Arabian Sea along the shelf/slope region (SARMA et... flows during May and November are in geostrophic balance or not. For this purpose we used the thermal wind equation Or_-g Op (1) Oz f Ox and substituted the observed values for the average shear (Ov/Oz) and cross-shore density gradient (Op...

  15. THE ARCHITECTURAL PATRONAGE AND POLITICAL PROWESS OF HEROD THE GREAT

    OpenAIRE

    Vivian A. Laughlin

    2016-01-01

    After supporting Marc Antony in the Battle of Actium (31 B.C.), King Herod, fearful of losing his power, went to Rome, apologized to Augustus and assured him that he was his biggest supporter. Augustus, giving Herod an opportunity to redeem himself, allowed him to return to Judea as King of the Jews. In an effort for Herod to express his continued commitment to Rome, he reconfigured his building styles by making cities that  would depict Rome in the Levant. Herod created architecture that imp...

  16. Romanticism of Khudekov Park. To semantics of Sochi "Arboretum"

    Directory of Open Access Journals (Sweden)

    Soltani Galina

    2015-12-01

    Full Text Available Park, as the autobiography of his Creator, reflects the events of the life of S. N. Khudekov, moral and aesthetic values, impressions, affections, transmitted through literary and mythological images. The semantics of small architectural forms multivalued and includes themes of Love, Faith, Hope, Patience, Justice, Families, Ballet, Literature, Military glory, in the Morning, creating a unified ensemble. The symbolism inherent in the Romantic style, is transmitted sculptures made by the famous French firm of Antonie Durеnne. The Khudekov’s Park is great not only the organic combination of different styles of landscape, but also its ideological content, expertly crafted fine connoisseur of art Sergey Nikolaevich Khudekov.

  17. Näitused / Mari Sobolev

    Index Scriptorium Estoniae

    Sobolev, Mari, 1968-

    1998-01-01

    Rotermanni soolaladu. "Elektrokardiogramm" (tegevuskunsti üritus); Vaal-galerii. Antoni T̉pies "Litograafiaid aastatest 1973-1995"; Mari Kadanik, Eero Barndõk, Rain Ader "Pildid" (maalid); Paldiski Põhikool. "Niemenlautta ja Hugo Simbergi fotod" (soome kunstniku fotode koopiad, pildistatud enne 1915. a.; Kullo lastegalerii. Neli uut näitust.(lastekunst); Arhitektuurimuuseum. Arnold Matteus - Tartu linna arhitekt (juubelinäitus), Alvar Aalto "Kolm objekti Eestis"; Linnagalerii Tallinnas. "Valge" (ruumi- ja moekunsti näitus); Sammas-galerii. Jüri Jegorow "Insect" (arvutigraafika); Endla Teatri palmisaal. "Muzik in der Kunst" (Tallinna kunstitudengite näitus); Eesti Rahvusraamatukogu. Õie Kütt "Uued ja vanad ehted"

  18. Areeni aastaalbumid 2005. Personaalsed edetabelid / Tõnu Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tõnu, 1966-2018

    2005-01-01

    Heliplaatidest: Ariel Pink's Haunted Graffiti "Worn Copy", Chalice "Süsteemsüsteem", Animal Collective "Feels", Röövel Ööbik "Supersymmetry", Arcade Fire "Funeral", Kanye West "Late Registration", White Stripes "Get Behind Me Satan", The Fall "Fall Heads Roll", Antony and the Johnsons "I Am a Bird Now", Sufjan Stevens "Illinoise", Bloc Party "Silent Alarm", LCD Soundsystem "LCD Soundsystem", Devendra Banhart "Cripple Crow", Architecture In Helsinki "In Case We Die", Kate Bush "Aerial", M.I.A. "Arular", Ans.Andur "Tuled peale", Gorillaz "Demon Days", Franz Ferdinand "You Could Have It So Much Better", Songs of Green Pheasant "Songs of Green Pheasant"

  19. The Arab Spring: An Essay on Revolution and Constitutionalism

    DEFF Research Database (Denmark)

    Abat Ninet, Antoni; Tushnet, Mark

    Approaching the concept of Islamic constitutionalism from a comparative perspective, this thought-provoking study by Antoni Abat i Ninet and Mark Tushnet uses traditional Western political theory as a lens to develop a framework for analyzing the events known as the ‘Arab Spring’. Writing...... with clarity and insight, the authors place Western and Arabic traditions into a constructive dialogue. They focus on whether we can develop a ‘theory of revolutions’ that helps us understand events occurring at divergent times at geographically separate locations....

  20. Community transmission of type 2 poliovirus after cessation of trivalent oral polio vaccine in Bangladesh: an open-label cluster-randomised trial and modelling study.

    Science.gov (United States)

    Taniuchi, Mami; Famulare, Michael; Zaman, Khalequ; Uddin, Md Jashim; Upfill-Brown, Alexander M; Ahmed, Tahmina; Saha, Parimalendu; Haque, Rashidul; Bandyopadhyay, Ananda S; Modlin, John F; Platts-Mills, James A; Houpt, Eric R; Yunus, Mohammed; Petri, William A

    2017-10-01

    Trivalent oral polio vaccine (tOPV) was replaced worldwide from April, 2016, by bivalent types 1 and 3 oral polio vaccine (bOPV) and one dose of inactivated polio vaccine (IPV) where available. The risk of transmission of type 2 poliovirus or Sabin 2 virus on re-introduction or resurgence of type 2 poliovirus after this switch is not understood completely. We aimed to assess the risk of Sabin 2 transmission after a polio vaccination campaign with a monovalent type 2 oral polio vaccine (mOPV2). We did an open-label cluster-randomised trial in villages in the Matlab region of Bangladesh. We randomly allocated villages (clusters) to either: tOPV at age 6 weeks, 10 weeks, and 14 weeks; or bOPV at age 6 weeks, 10 weeks, and 14 weeks and either one dose of IPV at age 14 weeks or two doses of IPV at age 14 weeks and 18 weeks. After completion of enrolment, we implemented an mOPV2 vaccination campaign that targeted 40% of children younger than 5 years, regardless of enrolment status. The primary outcome was Sabin 2 incidence in the 10 weeks after the campaign in per-protocol infants who did not receive mOPV2, as assessed by faecal shedding of Sabin 2 by reverse transcriptase quantitative PCR (RT-qPCR). The effect of previous immunity on incidence was also investigated with a dynamical model of poliovirus transmission to observe prevalence and incidence of Sabin 2 virus. This trial is registered at ClinicalTrials.gov, number NCT02477046. Between April 30, 2015, and Jan 14, 2016, individuals from 67 villages were enrolled to the study. 22 villages (300 infants) were randomly assigned tOPV, 23 villages (310 infants) were allocated bOPV and one dose of IPV, and 22 villages (329 infants) were assigned bOPV and two doses of IPV. Faecal shedding of Sabin 2 in infants who did not receive the mOPV2 challenge did not differ between children immunised with bOPV and one or two doses of IPV and those who received tOPV (15 of 252 [6%] vs six of 122 [4%]; odds ratio [OR] 1·29, 95% CI 0

  1. Detection of Toxolasma gondii in captive wild felids.

    Science.gov (United States)

    Buddhirongawatr, Ruangrat; Tungsudjai, Siriporn; Chaichoune, Kridsada; Sangloung, Charoonluk; Tantawiwattananon, Nitipan; Phonaknguen, Rassameepen; Sukthana, Yaowalark

    2006-01-01

    Toxoplasma gondii can infect all species of warm-blooded animals, including humans, and causes serious diseases in immunocompromized hosts. Live tachyzoites derived from serial passage in HeLa culture were used in the Sabin-Feldman dye test for detection of Toxoplasma gondii antibody in serum samples of 21 captive wild felids including one fishing cat (Prion nailurus viverrina), one leopard (Panthera pardus), two flat-headed cats (Prion nailurus planiceps), 6 tigers (Panthera tigris), two leopard cats (Felis bengalensis), two clouded leopards (Felis nebulosa), 3 pumas (Puma concolor), and 4 jungle cats (Felis chaus). Antibodies to Toxoplasma gondii were founded in 9 of 21 felids (42.8%). This study revealed that cell culture-derived tachyzoites can be used successfully as a source of live organisms in a gold standard Sabin-Feldman dye test, which is simpler, cheaper and less ethically sensitive than in vivo inoculation.

  2. Parim proosalugeja köitis küpsusega / Marika Rajamäe

    Index Scriptorium Estoniae

    Rajamäe, Marika, 1952-

    2008-01-01

    Toimus viies üle-eestiline proosalugemine "Hansenist Tammsaareni". Mõtteid võistulugemise kohta avaldavad konkursi algataja Enda Trubok, Järva maavalitsuse haridus- ja kultuuriosakonna peainspektor Anne Viljat, Eesti emakeeleõpetajate seltsi esimees Piret Järvela, žürii esimees Iivi Lepik, konkursil võistelnud Merilin Kulpsoo. Peavõidu sai Sabine Liias, V-VII klasside arvestuses läks I koht Sabine Liiasele, II koht Kristian Käreskile, III koht Kristiina Orasele. VIII-IX arvestuses läks I koht Katriin Altementile, II koht Indrek Jõele, III koht Linda Randojale. X-XII klasside arvestuses võitis Kaire Olesk, II koha saii Sten-Robert Pullerits ning III koha Katrin Ojalill

  3. Transmission coefficients of radiation dose equivalents in soil

    International Nuclear Information System (INIS)

    Simovic, R.; Marinkovic, N.

    1993-01-01

    In this paper an exponential formula wa proposed for calculating transmission of neutron and secondary gamma radiation through soil slabs. Parameters α and A of the transmission formula are given as rational functions dependent on the percent of water in the soil. Results are compared to those obtained by SABINE-3 code and a satisfactory agreement is shown for soil slab thicknesses for 50 - 500 cm (author) [sr

  4. New Approaches to Attenuated Hepatitis a Vaccine Development: Cloning and Sequencing of Cell-Culture Adapted Viral cDNA.

    Science.gov (United States)

    1987-10-13

    after multiple passages in vivo and in vitro. J. Gen. Virol. 67, 1741- 1744. Sabin , A.B. (1985). Oral poliovirus vaccine : history of its development...IN (N NEW APPROACHES TO ATTENUATED HEPATITIS A VACCINE DEVELOPMENT: Q) CLONING AND SEQUENCING OF CELL-CULTURE ADAPTED VIRAL cDNA I ANNUAL REPORT...6ll02Bsl0 A 055 11. TITLE (Include Security Classification) New Approaches to Attenuated Hepatitis A Vaccine Development: Cloning and Sequencing of Cell

  5. Superkangelased, kommertshiired ja sõjakad idaeurooplased / Joonas Sildre

    Index Scriptorium Estoniae

    Sildre, Joonas

    2003-01-01

    Rahvusvaheline koomiksifestival Berliinis 27.-31. VIII. Tuntumaid esinejaid - Roger Sabin. Näitused: "Ümber maailma 80 pildiga - rahvusvaheline koomiksikunst", "Kinderkids in Wonderland", "Miki ja Donaldi maailm läbi aegade", Art Spiegelmani "Kisses from New York", Helge Reumanni väljapanek. Eesti koomiks (Veiko Tammjärve, Joonas Sildre tööd) on esindatud Sloveenia koomiksikirjastuse Strip Core väljaannetes

  6. Serosurveillance of Viral Pathogens Circulating in West Africa

    Science.gov (United States)

    2016-05-20

    to be detected in the pan-280 assay utilized here and likely represent significant portions. Also, it is possible that YFV 281 vaccination may have...impacted the prevalence of flaviviruses recorded here; however, 282 distribution of the vaccine is notably irregular and a measure of its impact is...arthropods in Nigeria. Am J Trop Med Hyg. 1970 380 Sep;19(5):846–50. 381 13. Sabin AB, Schlesinger RW. Production of immunity to dengue with virus

  7. Medical Surveillance Monthly Report (MSMR). Volume 17, Number 06, June 2010

    Science.gov (United States)

    2010-06-01

    of vaccine safety and effi cacy trials, and advocacy for U.S. licensure of JE vaccines .9 During World War II, LTC Albert Sabin conducted pioneering...the improved safety profi le of second-generation vaccines , and the geographic spread of JE virus over the past 50 years warrant continued...control of JE, including characterization of the ecology of JEV, development of fi rst and second generation vaccines and diagnostic assays, conduct

  8. Pathogenesis of Dengue Vaccine Viruses in Mosquitoes.

    Science.gov (United States)

    1980-01-01

    1973). Sabin (1948) showed that attenuated dpngiie, passed through mosquitoes, did not revert to pathogenicity frnr man. -7- Thus even if the vaccine ...AD-A138 518 PATHOGENESIS OF DENGUE VACCINE YIRUSES IN MOSQUITOES 1/ (U) YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE B J BEATY ET AL. 9i JAN 80 DRND7...34 ’ UNCLASSIFIED 0{) AD 0Pathogenesis of dengue vaccine viruses in mosquitoes -First Annual Report Barry I. Beaty, Ph.D. Thomas H. G

  9. Mosquitoes: A Viable 21st-Century Soft Power Tool

    Science.gov (United States)

    2015-01-01

    treatment for dengue, and there is no vaccine . The U.S. military has had a long-term relationship with the ailment. During the Spanish-American War, the...scientist first isolated the virus during the war, and a United States Army physician, Albert Sabin , made the discov- ery that there were distinct...testing possible vaccines in its medical research facilities in the United States and Thailand. This long- term study by military personnel from 1900

  10. Antiviral activity of 3(2H- and 6-chloro-3(2H-isoflavenes against highly diverged, neurovirulent vaccine-derived, type2 poliovirus sewage isolates.

    Directory of Open Access Journals (Sweden)

    Lester M Shulman

    Full Text Available BACKGROUND: Substituted flavanoids interfere with uncoating of Enteroviruses including Sabin-2 polio vaccine strains. However flavanoid resistant and dependent, type-2 polio vaccine strains (minimally-diverged, emerged during in vitro infections. Between 1998-2009, highly-diverged (8 to >15% type-2, aVDPV(2s, from two unrelated persistent infections were periodically isolated from Israeli sewage. AIM: To determine whether highly evolved aVDPV(2s derived from persistent infections retained sensitivity to isoflavenes. METHODS: Sabin-2 and ten aVDPV(2 isolates from two independent Israeli sources were titered on HEp2C cells in the presence and absence of 3(2H- Isoflavene and 6-chloro-3(2H-Isoflavene. Neurovirulence of nine aVDPV(2s was measured in PVR-Tg-21 transgenic mice. Differences were related to unique amino acid substitutions within capsid proteins. PRINCIPAL FINDINGS: The presence of either flavanoid inhibited viral titers of Sabin-2 and nine of ten aVDPV(2s by one to two log(10. The tenth aVDPV(2, which had unique amino acid substitution distant from the isoflavene-binding pocket but clustered at the three- and five-fold axies of symmetry between capsomeres, was unaffected by both flavanoids. Genotypic neurovirulence attenuation sites in the 5'UTR and VP1 reverted in all aVDPV(2s and all reacquired a full neurovirulent phenotype except one with amino acid substitutions flanking the VP1 site. CONCLUSION: Both isoflavenes worked equally well against Sabin 2 and most of the highly-diverged, Israeli, aVDPV(2s isolates. Thus, functionality of the hydrophobic pocket may be unaffected by selective pressures exerted during persistent poliovirus infections. Amino acid substitutions at sites remote from the drug-binding pocket and adjacent to a neurovirulence attenuation site may influence flavanoid antiviral activity, and neurovirulence, respectively.

  11. Human Immune Response to Dengue Infections

    Science.gov (United States)

    1991-06-30

    had been immunized with yellow fever vaccine and later became infected with dengue 3 virus, responded best to dengue 3 antigen but also responded to...effective dengue virus subunit vaccines . We found evidence of marked T cell activation in patients with DHF. T cell activation in patients with DF was similar...Treatment and Control of Dengue Hemorrhagic Fever. World Health Organization, Geneva, Switzerland 7. Sabin AB (1952) Research on dengue during World

  12. Terrorist Group Profiles

    Science.gov (United States)

    1988-11-01

    Germany. Leadership Rudolph Raabe, Sonia Suder, Christian Gauger, Rudolf Schindler, Sabine Eckle. Other Names Revolutionaere Zellen, Rote Zora...through Jaime Guillot Lara, a Colombian drug smuggler, although no further operations of this type are known to have occurred. Since 1984, there have been...Attempted to assassinate Minister of Government Jaime Castro as he drove to work. July 1986 - Stole 1.6 million pesos from a bank in Bogota, wounding

  13. Kumu katusele maalitakse ühiskonnakriitiline sõnum / Oliver Õunmaa

    Index Scriptorium Estoniae

    Õunmaa, Oliver

    2011-01-01

    Euroopa meediakunsti näitus "Gateways. Kunst ja võrgustunud kultuur" Kumu Kunstimuuseumis 13.05.-25.09.2011. Kuraator Sabine Himmelsbach. Kunstnikud Achim Mohné ja Uta Kopp maalivad Kumu katusele sõnumi "Click here". Linnas olevatest töödest, eesti kunstniku Timo Tootsi installatsioonist "Memopol II" jt. töödest. Tutvustab näituse kuraator-assistent Ragne Nukk

  14. Current status of poliovirus infections.

    OpenAIRE

    Melnick, J L

    1996-01-01

    Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the numbe...

  15. Global Well-Posedness of the NLS System for Infinitely Many Fermions

    Science.gov (United States)

    Chen, Thomas; Hong, Younghun; Pavlović, Nataša

    2017-04-01

    In this paper, we study the mean field quantum fluctuation dynamics for a system of infinitely many fermions with delta pair interactions in the vicinity of an equilibrium solution (the Fermi sea) at zero temperature, in dimensions d = 2, 3, and prove global well-posedness of the corresponding Cauchy problem. Our work extends some of the recent important results obtained by Lewin and Sabin in [33,34], who addressed this problem for more regular pair interactions.

  16. A review of the studies on pteropods from the northern Indian Ocean A review of the studies on pteropods of the northern Indian Ocean region with a report on the pteropods of Irrawaddy continental shelf off Myanmar (Burma)

    Digital Repository Service at National Institute of Oceanography (India)

    Panchang, R.; Nigam, R.; Riedel, F.; Janssen, A.W.; Hla, U Ko Yi

    budget. Recent evidence, however, has suggested that the majority of the open ocean carbonate exported from the surface layer is remineralized in the upper 500�1000 m, well above the calcite lysocline 13 . Sabine et al. 14 , suggest that significant... was later dated to 13,000 y. BP. Bhattacharjee et al. 65 observed a similar event around Car Nicobar Islands and attributed both these features to reduced dissolution due to increased alkalinity, marking the beginning of deglaciation. In core sections...

  17. The Magnetic Observatory Buildings at the Royal Observatory, Cape

    Science.gov (United States)

    Glass, I. S.

    2015-10-01

    During the 1830s there arose a strong international movement, promoted by Carl Friedrich Gauss and Alexander von Humboldt, to characterise the earth's magnetic field. By 1839 the Royal Society in London, driven by Edward Sabine, had organised a "Magnetic Crusade" - the establishment of a series of magnetic and meteorological observatories around the British Empire, including New Zealand, Australia, St Helena and the Cape. This article outlines the history of the latter installation, its buildings and what became of them.

  18. セービンワクチンウイルスの凍結乾燥に関する研究 第1報. 凍結乾燥に関する基礎的条件の検討

    OpenAIRE

    塩見, 洋; 浦沢, 价子; 浦沢, 正三

    1997-01-01

    The development of a heat-stable poliovaccine preparation is urgently needed for the eradication of polio in tropical countries. In the present study, in order to obtain heat-stable lyophilized poliovaccine (type 1, 2 and 3 Sabin strains), conditions affecting the lyophilization of the vaccine viruses were studied. With regard to lyophilizing medium (medium used for suspending virus before lyophilization), the effect of a single chemical component, and double and tripple chemical components o...

  19. Production of Antigens and Antibodies for Diagnosis of Arbovirus Diseases.

    Science.gov (United States)

    1994-05-20

    for Germiston, Qalyub, Sicilian, vesicular stomatitis Indiana, and Ganjam viruses. The antigens were inactivated with beta-propiolactone. Rabbits were...vesicular stomatitis Indiana, and Ganjam viruses. The antigens were inactivated with beta-propiolactone. Rabbits were immunized successfully intravenously...370 sm4 6 229 Sicilian Sabin sm37,Vero2 1 23 VS-Indiana Ind. Lab sm7 1 45 Ganjam IG 619 sm5 1 67 Additionally, 22 viruses were passaged in baby mice

  20. Tänavast. Sotsiaalselt / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2010-01-01

    22.-23. septembril 2010 toimunud Eesti Kunstiakadeemia 7. urbanistika ja linnamaastiku päevade 2. osast, rahvusvahelisest konverentsist "Sotsiaalne tänav". Peaesinejad: Lars Gemzøe (Taani), Dago Antov, Sabine Knierbein (Austria), Zane Bērziņa (Läti/Saksamaa). Lisaprogrammis näidati arhitektuuriüliõpilaste poolt rahvusvahelise workshop'i CinemArchitecture raames tehtud linnateemalisi lühifilme

  1. punktum. Juni 2004

    OpenAIRE

    Aeschlimann, Heidi; Aeberli-Niquille, Christian Louis; Allemann, Rolf; Arnet, Esther; Burri Sharani, Barbara; Grünwald, Hugo Stephan; Gugger, Peter; Hürlimann, Fred W.; Meyer, Peter Michael; Meyer, Sara; Raeder, Sabine; Ruh, Hans; Schenker, Sybille; Wüthrich, Doris

    2004-01-01

    Meyer, Sara: Neue Lebensräume Arnet, Esther: Lebensraum Öffentlichkeit, Dürfen Politikerinnen Visionen haben? Burri Sharani, Barbara: Lebensraum Kosova, Die Frau des Bruders der Frau des ... Ruh, Hans (Prof.): Lebensraum Zeit, Höher weiter schneller länger? Meyer, Paul Michael: Lebensraum Schule, Warum ist hier möglich, was dort unmöglich scheint? Raeder Sabine (Dr.): Lebensraum Arbeit, Flexible Identitäten in flexibilisierten Arbeitsverhältnissen Gugger, Peter: Lebensraum...

  2. Proceedings of Conference on Language Documentation and Linguistic Theory 3

    OpenAIRE

    Austin, PK

    2011-01-01

    A collection dealing with language documentation and linguistic theory from a conference held at SOAS on 19- 20 November 2011. Papers by Peter Austin, Oliver Bond, Lutz Marten & David Nathan, Balthasar Bickel, Anju Saxena, Anvita Abbi, Cathryn Bartram, Henrik Bergqvist, Martine Bruil, Eliane Camargo & Sabine Reiter, Kearsy Cormier, Jordan Fenlon, Ramas Rentelis, & Adam Schembri, Simeon Floyd & Martine Bruil, Diana Forker, Michael Franjieh & Kilu von Prince, Brent Henderson & Charl...

  3. JPRS Report, East Europe.

    Science.gov (United States)

    1988-05-12

    member of a socialist state. [Question] One last question. Law in inextricably linked to morality. How would you characterize this interrela...4) (Ibid., pp 423-424) From the perspective of the direct link between the science of history and social-political practice, the party documents...a good pedo - logist, a finished expert on soil. Nica Sabin: It is well known that throughout the country there are soils that vary greatly in

  4. Patterns of species richness in sandy beaches of South America

    African Journals Online (AJOL)

    beaches with rdkctive and dissip:1tive characteristics (sensu. R eprodu ced by Sabin et G atew ay u n der licen ce gran ted by th e P u blish er (dated 2009). ... beach intertidal communities WaS reviewed, (b) location of len sam.!y beaches studied in south-central Chile, imd (c) location of two sandy beaches studied on the ...

  5. The Gymnosperm Cytochrome P450 CYP750B1 Catalyzes Stereospecific Monoterpene Hydroxylation of (+)-Sabinene in Thujone Biosynthesis in Western Redcedar1[OPEN

    Science.gov (United States)

    Blaukopf, Markus; Yuen, Macaire M.S.; Withers, Stephen G.; Mattsson, Jim; Russell, John H.; Bohlmann, Jörg

    2015-01-01

    Western redcedar (WRC; Thuja plicata) produces high amounts of oxygenated thujone monoterpenoids associated with resistance against herbivore feeding, particularly ungulate browsing. Thujones and other monoterpenoids accumulate in glandular structures in the foliage of WRC. Thujones are produced from (+)-sabinene by sabinol and sabinone. Using metabolite analysis, enzyme assays with WRC tissue extracts, cloning, and functional characterization of cytochrome P450 monooxygenases, we established that trans-sabin-3-ol but not cis-sabin-3-ol is the intermediate in thujone biosynthesis in WRC. Based on transcriptome analysis, full-length complementary DNA cloning, and characterization of expressed P450 proteins, we identified CYP750B1 and CYP76AA25 as the enzymes that catalyze the hydroxylation of (+)-sabinene to trans-sabin-3-ol. Gene-specific transcript analysis in contrasting WRC genotypes producing high and low amounts of monoterpenoids, including a glandless low-terpenoid clone, as well as assays for substrate specificity supported a biological role of CYP750B1 in α- and β-thujone biosynthesis. This P450 belongs to the apparently gymnosperm-specific CYP750 family and is, to our knowledge, the first member of this family to be functionally characterized. In contrast, CYP76AA25 has a broader substrate spectrum, also converting the sesquiterpene farnesene and the herbicide isoproturon, and its transcript profiles are not well correlated with thujone accumulation. PMID:25829465

  6. Rare adverse events associated with oral poliovirus vaccine in Brazil

    Directory of Open Access Journals (Sweden)

    Friedrich F.

    1997-01-01

    Full Text Available Oral poliovirus vaccine (OPV developed by A. Sabin has been effectively used to control poliomyelitis in Brazil, and the last case with the isolation of a wild poliovirus strain occurred in March 1989. Although the vaccine controlled the circulation of wild strains and poliomyelitis cases associated with these strains were not detected during the last eight years, rare cases classified as vaccine-associated paralytic poliomyelitis (VAPP have been detected. Molecular characterization studies of poliovirus strains isolated from VAPP cases and from healthy contacts have confirmed that the isolates are derived from the Sabin vaccine strains and also detected genomic modifications known or suspected to increase neurovirulence such as mutations and recombination. The molecular characterization of polioviruses isolated during the last eight years from paralysis cases classified as Guillain-Barré (GBS syndrome and transverse myelitits (TM, and from facial paralysis (FP cases also confirmed the vaccine origin of the strains and demonstrated mutations known to increase neurovirulence. Analysis of the epidemiologic data of these GBS, TM and FP cases demonstrated that in most of them the last OPV dose was given months or years before the onset of the disease and the isolation of the polioviruses. The temporal association between the isolation of these strains and the GBS, TM and FP suggested that the Sabin vaccine-derived poliovirus strains could also rarely trigger the diseases.

  7. Rare natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus isolated from a case of acute flaccid paralysis in Brazil, 2015.

    Science.gov (United States)

    Cassemiro, Klécia M S M; Burlandy, Fernanda M; da Silva, Edson E

    2016-07-01

    A natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus was isolated from an acute flaccid paralytic case in Brazil. Genome sequencing revealed the uncommon location of the crossover site in the VP1 coding region (nucleotides 3251-3258 of Sabin 3 genome). The Sabin 2 donor sequence replaced the last 118 nt of VP1, resulting in the substitution of the complete antigenic site IIIa by PV2-specific amino acids. The low overall number of nucleotide substitutions in P1 region indicated that the predicted replication time of the isolate was about 8-9 weeks. Two of the principal determinants of attenuation in Sabin 3 genomes were mutated (U472C and C2493U), but the temperature-sensitive phenotype of the isolate was preserved. Our results support the theory that there exists a PV3/PV2 recombination hotspot site in the tail region of the VP1 capsid protein and that the recombination may occur soon after oral poliovirus vaccine administration.

  8. Molecular Properties of Poliovirus Isolates: Nucleotide Sequence Analysis, Typing by PCR and Real-Time RT-PCR.

    Science.gov (United States)

    Burns, Cara C; Kilpatrick, David R; Iber, Jane C; Chen, Qi; Kew, Olen M

    2016-01-01

    Virologic surveillance is essential to the success of the World Health Organization initiative to eradicate poliomyelitis. Molecular methods have been used to detect polioviruses in tissue culture isolates derived from stool samples obtained through surveillance for acute flaccid paralysis. This chapter describes the use of realtime PCR assays to identify and serotype polioviruses. In particular, a degenerate, inosine-containing, panpoliovirus (panPV) PCR primer set is used to distinguish polioviruses from NPEVs. The high degree of nucleotide sequence diversity among polioviruses presents a challenge to the systematic design of nucleic acid-based reagents. To accommodate the wide variability and rapid evolution of poliovirus genomes, degenerate codon positions on the template were matched to mixed-base or deoxyinosine residues on both the primers and the TaqMan™ probes. Additional assays distinguish between Sabin vaccine strains and non-Sabin strains. This chapter also describes the use of generic poliovirus specific primers, along with degenerate and inosine-containing primers, for routine VP1 sequencing of poliovirus isolates. These primers, along with nondegenerate serotype-specific Sabin primers, can also be used to sequence individual polioviruses in mixtures.

  9. [Handbuch des personalen Gelegenheitsschrifttums in europäischen Bibliotheken und Archiven] / Jürgen Beyer

    Index Scriptorium Estoniae

    Beyer, Jürgen, 1965-

    2007-01-01

    Arvustus: Handbuch des personalen Gelegenheitsschrifttums in europäischen Bibliotheken und Archiven. Bd. 7., Reval - Tallinn. Estnische Akademische Bibliothek - Eesti Akadeemiline Raamatukogu ; Estnisches Historisches Museum - Eesti Ajaloomuuseum ; Estnische Nationalbibliothek - Eesti Rahvusraamatukogu ; Revaler Stadtarchiv - Tallinna Linnaarhiiv / mit einer bibliotheksgeschichtlichen Einleitung und einer kommentierten Bibliographie von Martin Klöker ; herausgegeben von Sabine Beckmann... [et al.]. - Hildesheim [etc.], 2003 ; Handbuch des personalen Gelegenheitsschrifttums in europäischen Bibliotheken und Archiven. Bd. 8., Dorpat - Tartu. Universitätsbibliothek - Ülikooli Raamatukogu ; Estnisches Literaturmuseum - Eesti Kirjandusmuuseum ; Estnisches Historisches Archiv - Eesti Ajalooarhiiv / mit einer bibliotheksgeschichtlichen Einleitung und einer kommentierten Bibliographie von Martin Klöker ; herausgegeben von Klaus Garber, Sabine Beckmann... [et al.]. - Hildesheim [etc.], 2003 ; Handbuch des personalen Gelegenheitsschrifttums in europäischen Bibliotheken und Archiven. Bd. 12-15, Riga: Akademische Bibliothek Lettlands. Historisches Staatsarchiv Lettlands. Spezialbibliothek des Archivwesens. Nationalbibliothek Lettlands. Baltische Zentrale Bibliothek. T. 1-4 / mit einer bibliotheksgeschichtlichen Einleitung und einer kommentierten Bibliographie von Martin Klöker ; herausgegeben von Sabine Beckmann und Martin Klöker unter Mitarbeit von Stefan Anders. - Hildesheim [etc.], 2004

  10. Tod der Płocker Bischöfe im Soldauer Konzentrationslager

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    Waldemar Graczyk

    2013-09-01

    Full Text Available In September 1939 in Działdowo the Nazis established a transit camp for the war prisoners of the Polish September Campaign of 1939 in the former barracks of the 32 infantry regiment on Grunwaldzka Street. At the turn of 1939 and 1940 the police and the SS authorities in Königsberg transformed the Działdowo camp into the transit camp „Durchgangslager“. Priests imprisoned in the Działdowo camp from autumn 1939 to autumn 1941 constituted a special group of political prisoners. The archbishop Antoni Julian Nowowiejski and the bishop Leon Wetmański, Płock bishop suffragan, were brought to the Działdowo camp in 1941. The Płock bishops quickly became spiritual guides and the support for the prisoners in difficult moments of camp life. In order to prevent their contacts with the prisoners, the bishops were put in a separate cell number 12. They were subjected to different kinds of moral and physical torture, including the attempt to profane the cross. Difficult living conditions in the camp soon led to the death of the Płock priests: the archbishop Antoni Julian Nowowiejski died on 28 May 1941 and the bishop Leon Wetmański died on 10 October 1941. Apart from them, 47 priests and 1 seminarian lost their lives in the Działdowo camp in 1939–1945.

  11. Imaging characteristics of intraparenchymal schwannoma and the related pathology

    International Nuclear Information System (INIS)

    Liu Shuyong; Geng Daoying; He Huijin

    2007-01-01

    Objective: To Analyze the imaging characteristics of intraparenchymal schwannoma and the related pathology, in order to improve the accuracy of diagnosis and be in favor of the clinics and the prognosis. Methods: Four cases were confirmed to be intraparenchymal schwannoma by pathological and immunohistochemistry examination. One case was examined with precontrast and enhanced CT scanning, one with unenhanced MRI scanning, two with unenhanced and enhanced CT and MRI scanning. Their images were retrospectively analyzed. Results: Of the four cases, three patients were less than 30 years old, with tumors located supratentorially. Cysts were found in all cases, with nodules on the wall in 3 cases. The nodules were enhanced markedly in two cases and moderately in one case. In addition, calcification was detected in one case and prominent peritumoral edema existed in 1 case. The picture of the pathology demonstrated Antoni type A and Antoni type B. Immunostaining showed intense immunoreactivity for S-100 protein and Vim and negative immunoreactivity for GFAP and EMA. Conclusions: Intraparenchymal schwannoma mostly occurred in juvenile, which located supratentorially in most cases. The presence of a cyst and peritumoral edema together with the tumor appears to be characteristic of intraparenchymal schwannoma. Calcification or the enhanced nodule is the helpful sign for the diagnosis. Combining the imaging findings with the pathology and immunohistochemistry results can gain the accurate diagnosis. (authors)

  12. Allied, MGC link on cyanate esters

    International Nuclear Information System (INIS)

    Wood, A.

    1993-01-01

    In the latest of a line of joint ventures in its plastics business, Allied Signal has reached agreement with Mitsubishi Gas Chemical (MGC) to jointly develop thermoset cyanate ester resins and blends. The deal will involve further development of Allied Signal's Primaset phenol-formaldehyde cyanate ester resins, a new entrant in the thermoset arena. Although the Primaset resins were discovered in the 1960s, this would be the first time they are available commercially. The deal will marry Primaset technology with MGC's Skylex bisphenol A cyanate ester resins, says Fred DiAntonis, director/advanced materials at Allied Signal. The two firms are looking at marketing blends of the two materials. The potential market for these resins, used commercially by the electronics industry in printed circuit boards and by the aerospace industry in composites, is significant, says Robert P. Viarengo, Allied Signal president/performance materials. By aligning ourselves with MGC, the world leader in cyanate ester resin, we anticipate moving forward aggressively. The main competitor is Ciba, which acquired bisphenol A cyanate ester resins with its purchase of Rhone-Poulenc's high temperature resins business. DiAntonis estimates the market for cyanate ester resins could be worth $150 million by the end of the decade, although development costs have been in the tens of millions of dollars range

  13. Estudios previos para la restauración de la azotea de la Casa Milá de Barcelona (Cataluña, España

    Directory of Open Access Journals (Sweden)

    Lacuesta Contreras, Raquel

    1993-12-01

    Full Text Available The Casa Milá of Barcelona, work of the architect Antoni Gaudí, built between 1906 and 1911, was purchased in by the Caixa de Catalunya which then started a process of restoration of the building. One of the stages of this intervention will consist of restoring the roof with all the architectural sculptural elements it contains (the staircase boxes, chimneys, ventilation towers and perimetral paths. A number of previous studies have been done to this end. They deal with the historical constructive, documentary and artistic aspects of all these elements as well as with an action proposal to be taken into account in the restoration project.

    La Casa Milá de Barcelona, obra del arquitecto Antoni Gaudí construida entre 1906 y 1911, fue adquirida en 1986 por la Caixa de Catalunya que a partir de entonces inició un proceso de restauración del edificio. Una de las fases de la intervención consistirá en restaurar la azotea con todos los elementos arquitectónicos-escultóricos que contiene (cajas de escalera, chimeneas, torres de ventilación y pasos de ronda. A tal fin, se han realizado unos estudios previos que contemplan los aspectos histórico-constructivos, documental y artístico de todos estos elementos, y también una propuesta de actuación a tener en cuenta en el proyecto de restauración.

  14. Intraosseous neurilemmoma of the mandible: report of a rare ancient type.

    Science.gov (United States)

    Jahanshahi, Gholamreza; Haghighat, Abbas; Azmoodeh, Faezeh

    2011-01-01

    The neurilemmoma is a benign neoplasm of Schwann cell origin. One of the histopathologic subtypes of this tumor is ancient schwannoma which is characterized by degenerative alterations including cystic change, calcification, hemorrhage, and hyalinization.Intraosseous schwannomas especially ancient ones are rare tumors. Here we present a case of intraosseous ancient schwannoma in the lower jaw of an 11-year-old girl which caused a non-tender expansion. Radiographic examination showed a well-circumscribed, unilocular radiolucent lesion with thin sclerotic borders in the mandibular body and the ramus. Histopathologic examination of the incisional biopsy showed areas of typical Antoni A with verocay bodies and Antoni B that was strongly suggestive of a schwannoma. Complete excision of the lesion was done under general anesthesia. The histopathologic examination confirmed the primary diagnosis and also degenerative changes such as hyalinization and calcification. Based on these findings, the diagnosis of ancient schwannoma was made. No recurrence was observed in the follow-up examination after 3 months.

  15. The imaging manifestation of intracranial schwannomas not arising from cranial nerves

    International Nuclear Information System (INIS)

    Luo Boning; Sun Gengxi; Liang Kangfu

    2003-01-01

    Objective: To report 4 cases of operation-confirmed intracranial schwannomas not arising from cranial nerves, and to discuss the histogenesis and CT and MRI manifestation combining with the literature. Methods: CT and MRI findings of these 4 intracranial schwannomas were analyzed retrospectively and their pathologic characteristics were reviewed. Results: The tumors demonstrated low-iso mixed density with necrotic and cystic areas. Large degeneration even became the prominent characteristics on CT scan. Low-signal to iso-signal intensity on T 1 -weighted images and heterogeneous high-signal intensity on T 2 -weighted images were revealed. The solid portion and the wall of the tumors were moderately enhanced on enhanced CT and MRI scans. Hematoxylin and eosin-stained sections showed two corresponding histological patterns: Antoni Type A and Antoni Type B pattern. The tumor cells exhibited a strong positive staining pattern for s-100 protein. Conclusion: The imaging manifestations of these tumors were similar to that of cranial nerve schwannomas except that the former had higher cystic degeneration rate. We should take that diagnosis into consideration when the mass is not located on cranial nerve but its image feature resembles schwannomas

  16. El discurs eclesiàstic davant el món visionari femení en els segles XVI i XVII

    Directory of Open Access Journals (Sweden)

    Rosa Mª Alabrús

    2016-12-01

    Full Text Available A l’article es descriu l’evolució del discurs eclesiàstic davant la religiositat femenina des de les primeres manifestacions d’il·luminisme. S’incideix en la significació de l’obra de Teresa de Jesús a la construcció del món visionari femení i s’analitzen especialment les actituds sobre el mateix de l’arxidiaca Juan de Horozco, del franciscà Gerónimo Planes i el carmelita descalç Antoni de Sant Maties Carbó. Es demostra l’esforç per conjugar la legitimitat de les visions de Teresa de Jesús amb els progressius recels eclesiàstics sobre l’imaginari femení. The article describes the evolution of ecclesiastical discourse about female religiosity from the first manifestations of Illuminism. It stands the significance of the work of Teresa of Jesus in the construction of the female visionary world. Attitudes on the question of Archdeacon Juan de Horozco, the Franciscan Gerónimo Planes and the Discalced Carmelite Maties de Sant Antoni Carbó are exposed. It demonstrated the effort by combining the legitimacy of the visions of Teresa with progressive ecclesiastical misgivings about the female imagination.

  17. Ecomorphometric structure of Restinga da Marambaia lizard community, Rio de Janeiro, southeastern Brazil Estrutura ecomorfométrica da comunidade de lagartos da Restinga da Marambaia, Rio de Janeiro, sudeste do Brasil

    Directory of Open Access Journals (Sweden)

    André L. G. de Carvalho

    2007-01-01

    Full Text Available In restinga areas of Marambaia, Rio de Janeiro, we recorded nine species of lizards, grouped in four families. The morphometric analysis suggested an invasion-structured pattern, with two distinct groups of species in the community: the "ground-runners", composed of animals with robust bodies and long limbs, represented by Tropidurus torquatus (Wied, 1820, Ameiva ameiva (Linnaeus, 1758, Liolaemus lutzae Mertens, 1938, Cnemidophorus littoralis Rocha, Araujo, Vrcibradic & Costa, 2000 and Tupinambis merianae (Duméril & Bibron, 1839; and the "hiders", composed of small-bodied animals with short limbs, represented by Hemidactylus mabouia (Moreau de Jonnès, 1818, Gymnodactylus darwinii (Gray, 1845, Mabuya agilis (Raddi, 1823 and M. macrorhyncha Hoge, 1947. The morphological relationships within the restinga lizard community reflect the influence of the habitat physical structure: bromeliad availability and other refugia, used by the "hiders", and the distribution of open areas, used by the "ground-runners". Our results also indicate that the restingas hold "ecomorphological spaces" (vacant niches available for occupation by additional lizard species.Em áreas de restinga da Marambaia, Rio de Janeiro, foram registradas nove espécies de lagartos, pertencentes a quatro famílias. A análise morfométrica sugeriu um padrão de estruturação por invasão, com dois grupos distintos de espécies compondo a comunidade: os "corredores de chão", formado pelos animais de corpo mais robusto e membros mais longos, representados por Tropidurus torquatus (Wied, 1820, Ameiva ameiva (Linnaeus, 1758, Liolaemus lutzae Mertens, 1938,Cnemidophorus littoralis Rocha, Araujo, Vrcibradic & Costa, 2000 e Tupinambis merianae (Duméril & Bibron, 1839; e os "escondedores", reunindo lagartos de menor tamanho e membros mais curtos, representados por Hemidactylus mabouia (Moreau de Jonnès, 1818, Gymnodactylus darwinii (Gray, 1845, Mabuya agilis (Raddi, 1823 e M. macrorhyncha

  18. Comparison of poliovirus recombinants: accumulation of point mutations provides further advantages.

    Science.gov (United States)

    Savolainen-Kopra, Carita; Samoilovich, Elena; Kahelin, Heidi; Hiekka, Anna-Kaisa; Hovi, Tapani; Roivainen, Merja

    2009-08-01

    The roles of recombination and accumulation of point mutations in the origin of new poliovirus (PV) characteristics have been hypothesized, but it is not known which are essential to evolution. We studied phenotypic differences between recombinant PV strains isolated from successive stool specimens of an oral PV vaccine recipient. The studied strains included three PV2/PV1 recombinants with increasing numbers of mutations in the VP1 gene, two of the three with an amino acid change I-->T in the DE-loop of VP1, their putative PV1 parent and strains Sabin 1 and 2. Growth of these viruses was examined in three cell lines: colorectal adenocarcinoma, neuroblastoma and HeLa. The main observation was a higher growth rate between 4 and 6 h post-infection of the two recombinants with the I-->T substitution. All recombinants grew at a higher rate than parental strains in the exponential phase of the replication cycle. In a temperature sensitivity test, the I-->T-substituted recombinants replicated equally well at an elevated temperature. Complete genome sequencing of the three recombinants revealed 12 (3), 19 (3) and 27 (3) nucleotide (amino acid) differences from Sabin. Mutations were located in regions defining attenuation, temperature sensitivity, antigenicity and the cis-acting replicating element. The recombination site was in the 5' end of 3D. In a competition assay, the most mutated recombinant beat parental Sabin in all three cell lines, strongly suggesting that this virus has an advantage. Two independent intertypic recombinants, PV3/PV1 and PV3/PV2, also showed similar growth advantages, but they also contained several point mutations. Thus, our data defend the hypothesis that accumulation of certain advantageous mutations plays a key role in gaining increased fitness.

  19. Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine.

    Science.gov (United States)

    Seid, Christopher A; Curti, Elena; Jones, R Mark; Hudspeth, Elissa; Rezende, Wanderson; Pollet, Jeroen; Center, Lori; Versteeg, Leroy; Pritchard, Sonya; Musiychuk, Konstantin; Yusibov, Vidadi; Hotez, Peter J; Bottazzi, Maria Elena

    2015-01-01

    Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human hookworm vaccine composed of the Necator americanus Glutathione S-Transferase-1 (Na-GST-1) and the Necator americanus Aspartic Protease-1 (Na-APR-1 (M74)) is currently under development by the Sabin Vaccine Institute Product Development Partnership (Sabin PDP). Both monovalent vaccines are currently in Phase 1 trials. Both Na-GST-1 and Na-APR-1 antigens are expressed as recombinant proteins. While Na-GST-1 was found to express with high yields in Pichia pastoris, the level of expression of Na-APR-1 in this host was too low to be suitable for a manufacturing process. When the tobacco plant Nicotiana benthamiana was evaluated as an expression system, acceptable levels of solubility, yield, and stability were attained. Observed expression levels of Na-APR-1 (M74) using this system are ∼300 mg/kg. Here we describe the achievements and obstacles encountered during process development as well as characterization and stability of the purified Na-APR-1 (M74) protein and formulated vaccine. The expression, purification and analysis of purified Na-APR-1 (M74) protein obtained from representative 5 kg reproducibility runs performed to qualify the Na-APR-1 (M74) production process is also presented. This process has been successfully transferred to a pilot plant and a 50 kg scale manufacturing campaign under current Good Manufacturing Practice (cGMP) has been performed. The 50 kg run has provided a sufficient amount of protein to support the ongoing hookworm vaccine development program of the Sabin PDP.

  20. Characteristics of an environmentally monitored prolonged type 2 vaccine derived poliovirus shedding episode that stopped without intervention.

    Directory of Open Access Journals (Sweden)

    Tapani Hovi

    Full Text Available Vaccine derived poliovirus (VDPV type 2 strains strongly divergent from the corresponding vaccine strain, Sabin 2, were repeatedly isolated from sewage in Slovakia over a period of 22 months in 2003-2005. Cell cultures of stool specimens from known immune deficient patients and from an identified putative source population of 500 people failed to identify the potential excretor(s of the virus. The occurrence of VDPV in sewage stopped without any intervention. No paralytic cases were reported in Slovakia during the episode. According to a GenBank search and similarity plotting-analysis, the closest known relative of the first isolate PV2/03/SVK/E783 through all main sections of the genome was the type 2 poliovirus Sabin strain, with nucleotide identities in 5'UTR, P1, P2, P3, and 3'UTR parts of the genome of 88.6, 85.9, 87.3, 88.5, and 94.0 percent, respectively. Phenotypic properties of selected Slovakian aVDPV strains resembled those of VDPV strains isolated from immune deficient individuals with prolonged PV infection (iVDPV, including antigenic changes and moderate neurovirulence in the transgenic mouse model. One hundred and two unique VP1 coding sequences were determined from VDPV strains isolated from 34 sewage specimens. Nucleotide differences from Sabin 2 in the VP1 coding region ranged from 12.5 to 15.6 percent, and reached a maximum of 9.6 percent between the VDPV strains under study. Most of the nucleotide substitutions were synonymous but as many as 93 amino acid positions out of 301 in VP1 showed substitutions. We conclude that (1 individuals with prolonged poliovirus infection are not as rare as suggested by the studies on immune deficient patients known to the health care systems and (2 genetic divergence of VDPV strains may remain extensive during years long replication in humans.

  1. Global Polio Eradication - Way Ahead.

    Science.gov (United States)

    Bahl, Sunil; Bhatnagar, Pankaj; Sutter, Roland W; Roesel, Sigrun; Zaffran, Michel

    2018-02-01

    In 1988, the World Health Assembly resolved to eradicate poliomyelitis by the year 2000. Although substantial progress was achieved by 2000, global polio eradication proved elusive. In India, the goal was accomplished in 2011, and the entire South-East Asia Region was certified as polio-free in 2014. The year 2016 marks the lowest wild poliovirus type 1 case count ever, the lowest number of polio-endemic countries (Afghanistan, Nigeria and Pakistan), the maintenance of wild poliovirus type 2 eradication, and the continued absence of wild poliovirus type 3 detection since 2012. The year also marks the Global Polio Eradication Initiative (GPEI) moving into the post-cessation of Sabin type 2, after the effort of globally synchronized withdrawal of Sabin type 2 poliovirus in April 2016. Sustained efforts will be needed to ensure polio eradication is accomplished, to overcome the access and security issues, and continue to improve the quality and reach of field operations. After that, surveillance (the "eyes and ears") will move further to the center stage. Sensitive surveillance will monitor the withdrawal of all Sabin polioviruses, and with facility containment, constitute the cornerstones for eventual global certification of wild poliovirus eradication. An emergency response capacity is essential to institute timely control measures should polio still re-emerge. Simultaneously, the public health community needs to determine whether and how to apply the polio-funded infrastructure to other priorities (after the GPEI funding has stopped). Eradication is the primary goal, but securing eradication will require continued efforts, dedicated resources, and a firm commitment by the global public health community.

  2. Characteristics of an Environmentally Monitored Prolonged Type 2 Vaccine Derived Poliovirus Shedding Episode that Stopped without Intervention

    Science.gov (United States)

    Hovi, Tapani; Paananen, Anja; Blomqvist, Soile; Savolainen-Kopra, Carita; Al-Hello, Haider; Smura, Teemu; Shimizu, Hiroyuki; Nadova, Katarina; Sobotova, Zdenka; Gavrilin, Eugene; Roivainen, Merja

    2013-01-01

    Vaccine derived poliovirus (VDPV) type 2 strains strongly divergent from the corresponding vaccine strain, Sabin 2, were repeatedly isolated from sewage in Slovakia over a period of 22 months in 2003–2005. Cell cultures of stool specimens from known immune deficient patients and from an identified putative source population of 500 people failed to identify the potential excretor(s) of the virus. The occurrence of VDPV in sewage stopped without any intervention. No paralytic cases were reported in Slovakia during the episode. According to a GenBank search and similarity plotting-analysis, the closest known relative of the first isolate PV2/03/SVK/E783 through all main sections of the genome was the type 2 poliovirus Sabin strain, with nucleotide identities in 5′UTR, P1, P2, P3, and 3′UTR parts of the genome of 88.6, 85.9, 87.3, 88.5, and 94.0 percent, respectively. Phenotypic properties of selected Slovakian aVDPV strains resembled those of VDPV strains isolated from immune deficient individuals with prolonged PV infection (iVDPV), including antigenic changes and moderate neurovirulence in the transgenic mouse model. One hundred and two unique VP1 coding sequences were determined from VDPV strains isolated from 34 sewage specimens. Nucleotide differences from Sabin 2 in the VP1 coding region ranged from 12.5 to 15.6 percent, and reached a maximum of 9.6 percent between the VDPV strains under study. Most of the nucleotide substitutions were synonymous but as many as 93 amino acid positions out of 301 in VP1 showed substitutions. We conclude that (1) individuals with prolonged poliovirus infection are not as rare as suggested by the studies on immune deficient patients known to the health care systems and (2) genetic divergence of VDPV strains may remain extensive during years long replication in humans. PMID:23935826

  3. [Genetic Characteristics of Type 2 Vaccine-derived Poliovirus in Shanxi Province (China) in 2014].

    Science.gov (United States)

    Yan, Dongrei; Li, Xiaolei; Zhang, Yong; Yang, Jianfang; Zhu, Shuangli; Wang, Dongyan; Zhang, Chuangye; Zhu, Hui; Xu, Wenbo

    2015-03-01

    The World Health Organization redefined the type 2 vaccine-derived poliovirus (VDPV) in 2010. To study the genetic characteristics and evolution of type 2 VDPV under this new definition, we conducted genome sequencing and analyses of type 2 VDPVs isolated from one patient with acute flaccid paralysis in Shanxi province (China) in 2014. Nucleotide sequencing revealed that the full-length of type 2 VDPV is 7439 bases encoding 2207 amino acids with no insertion or deletion of nucleotides compared with Sabin2. One nucleotide substitution identified as a key determinant of the attenuated phenotype of the Sabin 2 strain (A-G reversion at nucleotide nt 481 in the 5-end of the untranslated region) had reverted in the Shanxi type 2 VDPV. The other known key determinant of the attenuated phenotype of the Sabin 2 strain (U-->C reversion at nt2909 in the VP1 coding region that caused a Ile143Thr substitution in VP1) had not reverted in the Shanxi VDPV. The Shanxi type 2 VDPV was S2/S1 recombinant, the crossover site of which mapped to the 3-end of the 3D region (between nt 6247 and nt 6281). A phylogentic tree based on the VP1 coding region showed that evolution of the Shanxi type 2 VDPV was independent of other type 2 VDPVs detected worldwide. We estimated that the strain circulated for approximately = 11 months in the population according to the known evolution rate. The present study confirmed that the Chinese Polio Laboratory Network could discover the VDPV promptly and that it played an important part in maintenance of a polio-free China.

  4. Real-time reverse transcription-polymerase chain reaction assays for identification of wild poliovirus 1 & 3.

    Science.gov (United States)

    Sharma, Deepa K; Nalavade, Uma P; Deshpande, Jagadish M

    2015-10-01

    The poliovirus serotype identification and intratypic differentiation by real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay is suitable for serotype mixtures but not for intratypic mixtures of wild and vaccine poliovirus strains. This study was undertaken to develop wild poliovirus 1 and 3 (WPV1 and WPV3) specific rRT-PCR assays for use. Specific primers and probes for rRT-PCR were designed based on VP1 sequences of WPV1 and WPV3 isolated in India since 2000. The specificity of the rRT-PCR assays was evaluated using WPV1 and WPV3 of different genetic lineages, non-polio enteroviruses (NPEVs) and mixtures of wild/wild and wild/Sabin vaccine strains. The sensitivity of the assays was determined by testing serial 10-fold dilutions of wild poliovirus 1 and 3 stock suspensions of known titre. No cross-reactivity with Sabin strains, intertypic wild poliovirus isolates or 27 types of NPEVs across all the four Enterovirus species was found for both the wild poliovirus 1 and 3 rRT-PCR assays. All WPV1 and WPV3 strains isolated since 2000 were successfully amplified. The rRT-PCR assays detected 10 4.40 CCID 50 /ml of WPV1 and 10 4.00 CCID 50 /ml of WPV3, respectively either as single isolate or mixture with Sabin vaccine strains or intertypic wild poliovirus. rRT-PCR assays for WPV1 and WPV3 have been validated to detect all the genetic variations of the WPV1 and WPV3 isolated in India for the last decade. When used in combination with the current rRT-PCR assay testing was complete for confirmation of the presence of wild poliovirus in intratypic mixtures.

  5. Yoga club

    CERN Multimedia

    Yoga club

    2016-01-01

    Il reste des places dans certains cours de yoga. Sabine Sourny Massonnet propose trois cours de yoga dynamique : Lundi – 12 h 15 à 13 h 30 Mardi – 17 h 15 à 18 h 15 Jeudi – 17 h 15 à 18 h 15 Les cours ont lieu sur la mezzanine du bâtiment 504. L’attention est portée sur un enchainement de postures, la synchronisation du mouvement au souffle, la relaxation et la méditation. Contact: icideja@yahoo.fr http://home.cern/cern-people/clubs/yoga-club

  6. Yoga club

    CERN Multimedia

    Yoga club

    2016-01-01

    https://club-yoga.web.cern.ch/ Club de yoga : les cours continuent en été Daniel Anner - Monday 17.00 – 18.00 Dynamic power yoga, English and French Contact: grooveyoga@gmail.com Sabine Sourny Massonnet (français) - lundi 8, 15, 22, 29 août, 12h15 - 13h30 L’attention est portée sur un enchainement de postures dynamiques, la synchronisation du mouvement au souffle, la relaxation & la méditation. Contact: icideja@yahoo.fr

  7. Comparative Infectivity Determinations of Dengue Virus Vaccine Candidates in Rhesus Monkeys, Mosquitoes, and Cell Cultures

    Science.gov (United States)

    1993-01-28

    34 are required for the evaluation of these vaccine candidates. RE: DAMDI7-89-C-9175 Page 16 REFERENCES 1. Sabin AB, Sclesinger RW, 1945. Production of...AD-A261 892 CONTRACT NO: DAMD17-89-C-9 175 \\II\\IllI\\I\\I1\\\\~il\\ TITLE: COMPARATIVE INFECTIVITY DETERMINATIONS OF DENGUE VIRUS VACCINE CANDIDATES IN... Vaccine Candidates in Rhesus Monkeys, 63002A Mosquitoes, and Cell Cultures 3M263002D870 AC 6. AUTHOR(S) DA335475 Edmundo Kraiselburd 7. PERFORMING

  8. A Model International Partnership for Community-based Research on Vaccine-preventable Diseases: the Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU)

    Science.gov (United States)

    2013-01-01

    4500 Table 3 Acknowledgment of contributions. Participant Role Albert Sabin Led effort to make JEV Vaccine during WWII Richard Mason Member of...R A v R R K D S a b c d e f g h i j a A R R A A K V S J H D I C T P p ( C t 0 h Vaccine 31 (2013) 4487– 4500 Contents lists available at...ScienceDirect Vaccine jou rn al hom ep age: www.elsev ier .com/ locat e/vacc ine eview model international partnership for community-based research on

  9. FDA Regulation of Follow-On Biologics

    Science.gov (United States)

    2009-02-24

    opening a pathway for the approval of follow-on biologics. A biologic is a preparation, such as a drug or a vaccine , that is made from living...2006 Drug Trend Report, April 2006, p. 38. C Biologic vs. Follow-on Biologic A biologic is a preparation, such as a drug or a vaccine , that is...doc9496/s1695.pdf. 19 Thijs J. Giezen, Aukje K. Mantel-Teeuwisse, and Sabine M. J. M. Straus, et al., “Safety-related regulatory actions for biologicals

  10. Ausencia de circulación de poliovirus en departamentos colombianos con coberturas vacunales inferiores a 80% Absence of poliovirus circulation in Colombian departments with vaccination coverage below 80%

    Directory of Open Access Journals (Sweden)

    María Mercedes González

    2012-08-01

    Full Text Available El presente estudio se propuso explorar la posible circulación silente de poliovirus salvajes y derivados de la vacuna (VDPV, por sus siglas en inglés, en departamentos de Colombia con cobertura de vacunación para polio (OPV, por sus siglas en inglés menor de 80%. Se colectaron 52 muestras de aguas residuales que se concentraron mediante precipitación con polietilenglicol y cloruro de sodio. La detección viral se realizó mediante aislamiento y la identificación por neutralización del efecto citopático, así como mediante reacción en cadena de la polimerasa convencional y en tiempo real, posterior a la transcripción reversa (TR-RCP y rTR-RCP. Los poliovirus aislados se caracterizaron por secuenciación del gen VP1. En dos de las 52 muestras hubo presencia de poliovirus Sabin 2 con más de 99% de similitud de secuencia con la cepa OPV Sabin 2. Se detectó circulación de enterovirus no polio en 17,3% de las muestras. Los serotipos identificados correspondieron a coxsackievirus B1, echovirus 30 y echovirus 11. No se detectaron evidencias de circulación de VDPV ni poliovirus salvaje en los departamentos de Colombia con coberturas de OPV inferiores a 80%.This study aims to explore a possible silent circulation of wild and vaccine-derived polioviruses in departments of Colombia with polio vaccination coverage of below 80%. The study collected 52 samples of wastewater concentrated as a result of precipitation with polyethylene glycol and sodium chloride. The viral detection was carried out through isolation and the identification through neutralization of the cytopathic effect, as well as through a conventional polymerase chain reaction following reverse transcription. The isolated polioviruses were characterized by the VP1 gene sequence. In two of the 52 samples, there was a presence of the Sabin type 2 poliovirus with more than 99% sequence similarity with the Sabin type 2 strain polio. Circulation of the nonpolio enterovirus was

  11. Buen Gobierno: Chronicles of Violence Committed Against Amerindians in the Andes

    OpenAIRE

    Arij Ouweneel

    2017-01-01

    Book Review Essay Unlocking the Doors to the Worlds of Guaman Poma and His Nueva corónica, edited by Rolena Adorno and Ivan Boserup. Copenhagen: The Royal Library and Museum Tusculanum Press, 2015. The Chankas and the Priest: A Tale of Murder and Exile in Highland Peru, by Sabine Hyland. University Park, PA: The Pennsylvania State University Press, 2016. Art from a Fractured Past: Memory and Truth-telling in Post-shining Path Peru, edited by Cynthia E. Milton; with an Afterword by Steve J. St...

  12. How to Dispel the Fog over the Past? Post-War Children, Their Fathers-Soldiers and Consequences of the Second World War

    OpenAIRE

    Ekaterina S. Lyubomirova

    2016-01-01

    The article is devoted to the new aspects in the study of the history of post-war Germany, revealed in the book written by Sabine Bode «Post-war children - born in the 1950s, and their fathers-soldiers». It discusses the contribution made by Bode in the study of mental and psycho-emotional consequences of the Second World War and the «exclusion of the past», which is reflected in the fate of the post-war children and continues to have an impact on the socio-political life of the Federal Repub...

  13. WordPress web design for dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2013-01-01

    Updated, full-color guide to creating dynamic websites with WordPress 3.6 In this updated new edition, bestselling For Dummies author and WordPress expert Lisa Sabin-Wilson makes it easy for anyone with a basic knowledge of the WordPress software to create a custom site using complementary technologies such as CSS, HTML, PHP, and MySQL. You'll not only get up to speed on essential tools and technologies and further advance your own design skills, this book also gives you pages of great case studies, so you can see just how other companies and individuals are creating compelling, customized, a

  14. Constantin Levaditi (1874-1953): a pioneer in Immunology and Virology.

    Science.gov (United States)

    Kalantzis, George; Skiadas, Panagiotis; Lascaratos, John

    2006-08-01

    The eminent doctor Constantin Levaditi represents one of the most important researchers in the field of medicine in the 20th century. Although he was engaged in many areas of the rapidly growing field of immunology, his name is associated mainly with research in poliomyelitis. His laboratory research contributed decisively to the clarification of the epidemiology of this dreadful disease that claimed thousands of victims. Moreover, his experimental work constituted the basis for the development of the vaccine against poliomyelitis, initially in 1955 by Jonas Salk (1914-95) using inactivated virus, and then in 1960 by Albert Sabin (1906-93) who used live attenuated virus.

  15. Submesoscale cyclones in the Agulhas Current

    CSIR Research Space (South Africa)

    Krug, Marjolaine

    2017-01-01

    Full Text Available of about 0.6m s�1. Surface currents were considerably stronger, averaging 0.4m s�1 and reaching maximum values of 1.8m s�1. The strongest surface currents were toward the southwest and observed in deep waters, where the gliders approached the AC (Figures 1c..., J. Phys. Oceanogr., 45(9), 2294–2314. Eriksen, C. C., T. J. Osse, R. D. Light, T. Wen, T. W. Lehman, P. L. Sabin, J. W. Ballard, and A. M. Chiodi (2001), Seaglider: A long-range auton- omous underwater vehicle for oceanographic research, IEEE J...

  16. Integration of high resolution geophysical methods. Detection of shallow depth bodies of archaeological interest

    Energy Technology Data Exchange (ETDEWEB)

    Cammarano, F.; Piro, S.; Rosso, F.; Versino, L. [Centro Nazionale delle Ricerche, Rome (Italy). Istituto per le Tecnologie Applicate ai Beni Culturali; Mauriello, P. [Neaples, Univ. `Federico II` (Italy). Dip. di Scienze Fisiche

    1998-08-01

    A combined survey using ground penetrating radar, self-potential, geo electrical and magnetic methods has been carried out to detect near-surface tombs in the archaeological test site of the Sabine Necropolis at Colle del Forno, Rome, Italy. A 2D data acquisition mode has been adopted to obtain a 3D image of the investigated volumes. The multi-methodological approach has not only demonstrated the reliability of each method in delineating the spatial behaviour of the governing parameter, but mainly helped to obtain a detailed physical image closely conforming to the target geometry through the whole set of parameters involved

  17. Integration of high resolution geophysical methods. Detection of shallow depth bodies of archaeological interest

    Directory of Open Access Journals (Sweden)

    F. Rosso

    1998-06-01

    Full Text Available A combined survey using ground penetrating radar, self-potential, geoelectrical and magnetic methods has been carried out to detect near-surface tombs in the archaeological test site of the Sabine Necropolis at Colle del Forno, Rome, Italy. A 2D data acquisition mode has been adopted to obtain a 3D image of the investigated volumes. The multi-methodological approach has not only demonstrated the reliability of each method in delineating the spatial behaviour of the governing parameter, but mainly helped to obtain a detailed physical image closely conforming to the target geometry through the whole set of parameters involved.

  18. WordPress all-in-one for dummies

    CERN Document Server

    Sabin-Wilson, Lisa

    2013-01-01

    Top WordPress guide, now fully updated for the latest WordPress release! This updated new edition comprises one of the largest collections of practical intermediate to advanced information on WordPress. Fully updated for the latest WordPress release, this in-depth book covers it all, from setting up your software to publishing your site, using SEO and social media, developing and using plug-ins, running multiple sites with WordPress, and more. Veteran author Lisa Sabin-Wilson is a top authority on WordPress, and she and her co-authors pack this book with essential and easy-to-follo

  19. Polio and Measles Down the Drain: Environmental Enterovirus Surveillance in the Netherlands, 2005 to 2015.

    Science.gov (United States)

    Benschop, Kimberley S M; van der Avoort, Harrie G; Jusic, Edin; Vennema, Harry; van Binnendijk, Rob; Duizer, Erwin

    2017-07-01

    Polioviruses (PVs) are members of the genus Enterovirus In the Netherlands, the exclusion of PV circulation is based on clinical enterovirus (EV) surveillance (CEVS) of EV-positive cases and routine environmental EV surveillance (EEVS) conducted on sewage samples collected in the region of the Netherlands where vaccination coverage is low due to religious reasons. We compared the EEVS data to those of the CEVS to gain insight into the relevance of EEVS for poliovirus and nonpolio enterovirus surveillance. Following the polio outbreak in Syria, EEVS was performed at the primary refugee center in Ter Apel in the Netherlands, and data were compared to those of CEVS and EEVS. Furthermore, we assessed the feasibility of poliovirus detection by EEVS using measles virus detection in sewage during a measles outbreak as a proxy. Two Sabin-like PVs were found in routine EEVS, 11 Sabin-like PVs were detected in the CEVS, and one Sabin-like PV was found in the Ter Apel sewage. We observed significant differences between the three programs regarding which EVs were found. In 6 sewage samples collected during the measles outbreak in 2013, measles virus RNA was detected in regions where measles cases were identified. In conclusion, we detected PVs, nonpolio EVs, and measles virus in sewage and showed that environmental surveillance is useful for poliovirus detection in the Netherlands, where live oral poliovirus vaccine is not used and communities with lower vaccination coverage exist. EEVS led to the detection of EV types not seen in the CEVS, showing that EEVS is complementary to CEVS. IMPORTANCE We show that environmental enterovirus surveillance complements clinical enterovirus surveillance for poliovirus detection, or exclusion, and for nonpolio enterovirus surveillance. Even in the presence of adequate surveillance, only a very limited number of Sabin-like poliovirus strains were detected in a 10-year period, and no signs of transmission of oral polio vaccine (OPV) strains

  20. Lecture Notes On Acoustics

    International Nuclear Information System (INIS)

    Kim, Yang Han

    2005-09-01

    This book mentions string vibration and wave, one-dimension wave and wave equation, characteristic impedance, governing equation of string, and wave energy from string, wave equation of wave and basic physical quantity like one-dimension wave equation, sound unit, sound intensity and energy, sound movement in a surface of discontinuity with transmission loss of sound by partition, and Snell's law, radiation, scatter and diffraction and sound in closed space with Sabine's theory, sound characteristic of closed space and duct acoustics.

  1. Memory in Comics: Testimonial, Autobiographical and Historical Space in MAUS

    Directory of Open Access Journals (Sweden)

    Ana Merino

    2010-10-01

    Full Text Available IntroductionIn Adult Comics: An Introduction Roger Sabin explained how between 1986 and 1987 the term ‘graphic novel’ became recognized mostly as a result of the success of Frank Miller’s Batman: The Dark Knight Returns, Alan Moore and Dave Gibbons’ Watchmen, and Art Spiegelman’s MAUS. This type of comic signified a revolutionary evolution towards an elaborate adult perspective. From the lesser and ephemeral space of the children’s comic, there was a shift towards the graphic novels for adult...

  2. Towards an integrated observing system for ocean carbon and biogeochemistry at a time of change

    CSIR Research Space (South Africa)

    Gruber, N

    2009-09-01

    Full Text Available . The longest time-series for inorganic carbon started in the early 1980s (Keeling, 1993, Gruber et al., 2001; Bates, 1997) near Bermuda and in 1988 was joined by a second time-series near Hawaii (Sabine et al., 1995; Dore et al., 2003; Keeling et al., 2004... century primarily as a result of the burning of fossil fuels (Sarmiento and Gruber, 2002). In response, atmospheric CO2 has GRUBER ET AL: AN INTEGRATED BIOGEOCHEMICAL OBSERVING SYSTEM 2 increased by more than 100 ppm (30%), with today’s concentration...

  3. La réactivité des matériaux argileux sous gradient thermique

    OpenAIRE

    Kohler , Eric

    2005-01-01

    Directrice de thèse : Catherine Beaucaire CEA Saclay Président du jury: Daniel Tessier INRA Versailles Rapporteurs : Martine Buatier Université de Franche-Comté, Besançon Sabine Petit Université de Poitiers Examinateurs : Justo Cabrera IRSN Fontenay aux Roses Michel Jullien CEA Cadarache Sid Labdi Université d'Evry Val d'Essonne Joël Raynal CEA Cadarache; The argillaceous materials properties could be favourable to the radioelements confinement in high activity and thermogenic nuclear waste d...

  4. Work Hours as a Moderator of the Relationship between Developmental Human Resource Management Practices and the Psychological Contract: A Multilevel Investigation

    OpenAIRE

    Håkensen, Katrine

    2014-01-01

    Purpose & background – The purpose of this study was to examine if part-time and full-time employees differ in terms of psychological contract content according to level of developmental HRM practices. The study adds to an ongoing research project Organizational antecedents of psychological contracts and work-related outcomes , run by Sabine Raeder, University of Oslo in cooperation with José María Peiró, University of Valencia, Spain. Design & methodology – A survey of 463 employees from 35...

  5. WordPress all-in-one for dummies

    CERN Document Server

    Sabin-Wilson, Lisa; Palmer, Kevin

    2011-01-01

    A convenient how-to guide for maximizing your WordPress experience. WordPress is a state-of-the-art blog publishing platform with nearly ten million active installations. Eight minibooks provide you with expanded coverage of the most important topics to the WordPress community, such as WordPress basics, theme designs, plug-in development, social media integration, SEO, customization, and running multiple sites. Veteran author Lisa Sabin-Wilson leads an authoritative team of authors who offer their unique knowledge and skillset while sharing invaluable advice for maximizing your site's potentia

  6. A forgotten chapter of Mexican technology and science: Luis Gutiérrez Villegas and poliomyelitis in Mexico.

    Science.gov (United States)

    Velázquez-Arellano, Antonio

    Two different types of vaccines were developed against poliomyelitis: The Salk vaccine using inactivated virus and the Sabin one, that was used later, after investigations assured its safety. The first one was made in Mexico with its own resources since 1957 thanks to the efforts of young researchers and technicians coordinated by Luis Gutiérrez-Villegas, M.D., who was a Clinical Pathologist, University Professor and President of the Mexican National Academy of Mexico. Copyright: © 2017 SecretarÍa de Salud.

  7. Land Area Change and Fractional Water Maps in the Chenier Plain, Louisiana, following Hurricane Rita (2005)

    Science.gov (United States)

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Brock, John C.

    2010-01-01

    In this study, we estimated the changes in land and water coverage of a 1,961-square-kilometer (km2) area in Louisiana's Chenier Plain. The study area is roughly centered on the Sabine National Wildlife Refuge, which was impacted by Hurricane Rita on September 24, 2005. The objective of this study is twofold: (1) to provide pre- and post-Hurricane Rita moderate-resolution (30-meter (m)) fractional water maps based upon multiple source images, and (2) to quantify land and water coverage changes due to Hurricane Rita.

  8. Social contract theory and just decision making: lessons from genetic testing for the BRCA mutations.

    Science.gov (United States)

    Williams-Jones, Bryn; Burgess, Michael M

    2004-06-01

    Decisions about funding health services are crucial to controlling costs in health care insurance plans, yet they encounter serious challenges from intellectual property protection--e.g., patents--of health care services. Using Myriad Genetics' commercial genetic susceptibility test for hereditary breast cancer (BRCA testing) in the context of the Canadian health insurance system as a case study, this paper applies concepts from social contract theory to help develop more just and rational approaches to health care decision making. Specifically, Daniel's and Sabin's "accountability for reasonableness" is compared to broader notions of public consultation, demonstrating that expert assessments in specific decisions must be transparent and accountable and supplemented by public consultation.

  9. Friedrichs systems in a Hilbert space framework: Solvability and multiplicity

    Science.gov (United States)

    Antonić, N.; Erceg, M.; Michelangeli, A.

    2017-12-01

    The Friedrichs (1958) theory of positive symmetric systems of first order partial differential equations encompasses many standard equations of mathematical physics, irrespective of their type. This theory was recast in an abstract Hilbert space setting by Ern, Guermond and Caplain (2007), and by Antonić and Burazin (2010). In this work we make a further step, presenting a purely operator-theoretic description of abstract Friedrichs systems, and proving that any pair of abstract Friedrichs operators admits bijective extensions with a signed boundary map. Moreover, we provide sufficient and necessary conditions for existence of infinitely many such pairs of spaces, and by the universal operator extension theory (Grubb, 1968) we get a complete identification of all such pairs, which we illustrate on two concrete one-dimensional examples.

  10. Scrub typhus: risks, diagnostic issues, and management challenges

    Directory of Open Access Journals (Sweden)

    Prakash JAJ

    2017-08-01

    Full Text Available John Antony Jude Prakash Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India Abstract: Scrub typhus is an acute febrile illness in the “tsutsugamushi triangle”, transmitted by chiggers that can be treated effectively if detected early. Laboratory testing, including molecular and serological assays, is needed for confirming the diagnosis, especially in the absence of the pathognomonic eschar. In this review, factors that play a role in disease occurrence and clinical clues for diagnosis, in addition to risk factors contributing to disease severity, including mortality, are discussed in detail. Moreover, issues related to diagnostic assays, treatment, and mixed infections are also enumerated and described. Keywords: Orientia tsutsugamushi, disease severity, mortality predictors, diagnosis, coinfections, treatment

  11. Systematic monitoring of atmosphere radioactivity on the main French nuclear sites in 1961; Surveillance systematique de la radioactivite de l'atmosphere sur les principaux sites nucleaires francais en 1961

    Energy Technology Data Exchange (ETDEWEB)

    Doury, A.

    1963-07-01

    After having indicated the different stations, departments and bodies involved in the monitoring of radioactivity for radiation protection purposes (notably CEA, EDF, National Navy for their establishments in Saclay, Le Bouchet, Grenoble, Marcoule, Cadarache, Cherbourg, Chinon, Antony) and briefly described how this network operates, this report presents the measurement program which comprises measurements of global instantaneous radioactivity at the vicinity of the ground, measurements of long life radioactivity, the identification and dosing of long life radio-elements, and additional measurements. It presents sampling and measurement methods for these different measurements performed on different forms of radioactive elements (airborne dusts, gas, gamma and cosmic ambient radiation, precipitations). Results are discussed and presented under tabular and graphical forms.

  12. No evidence for extensions to the standard cosmological model

    CSIR Research Space (South Africa)

    Heavens, A

    2017-09-01

    Full Text Available , the Bayesian evidence depends on the priors chosen. Here we have used uniform box priors (in addition, cosmoMCexcludes some physically impossible subregions) based on the 2015 Planck analysis (Antony Lewis), and these are listed in Table I. For parameter... density today ωc ≡ Ωch2 [0.001, 0.99] … Cold dark matter density today 100θMC [0.5, 10] … 100× approximation to r�=DA (CosmoMC) τ [0.01, 0.8] … Thomson scattering optical depth due to reionization lnð1010AsÞ [2, 4] … Log power of the primordial curvature...

  13. La difusión de la teoría evolucionista de Lamarck en la revista La Abeja

    OpenAIRE

    Camós Cabeceran, Agustí

    1997-01-01

    La obra de Lamarck fue difundida, entre los años 1862 y 1865, por la revista La Abeja dirigida por Antoni Bergnes de las Casas y publicada en Barcelona. En dicha revista aparece explicada la teoría evolucionista de Lamarck tanto en la traducción de su obra. Histoire naturelle des végétaux, como en una serie de artículos anónimos sobre la reproducción de los seres vivos. Estos datos pueden revelar que, en la introducción del evolucionismo en España, la teoría evolucionista de Lamarck tuvo mayo...

  14. Intoduction to the Issue (2011/2

    Directory of Open Access Journals (Sweden)

    Wojciech HANUSZKIEWICZ

    2011-12-01

    Full Text Available Seven articles — out of the nine presented here to the Reader — undertake our leading theme: Tracing Liminal and Boundary Experience in Philosophical and Religious Discourse. Three articles from that group (written by Małgorzata Bogaczyk-Vormayr, Piotr Augustyniak and Anna Szyrwińskaexplore various aspects of the boundary experience in a historical perspective. The next four pick up the same theme in a contemporary perspective: the articles of Joachim Piecuch, Tadeusz Gadacz and Antoni Szwed discuss the philosophy of Józef Tischner, the article by Urszula Idziak presents the debate between Jacques Derrida and Paul Ricoeur concerning the boundary experience of death. The remaining two articles published here are not connected with the leading theme — Magdalena Nowak presents a history of the concept of Einfühlung and Jacquette Dale tries to improve the diagram method used in logical argument analysis.

  15. Process management tools in higher education e-learning

    DEFF Research Database (Denmark)

    Levinsen, Karin

    2005-01-01

    Online education is a growing trend world wide - eg. in-service training in large, especially trans- and multinational organizations (Turban et al. 2006); online and blended mode educations at universities (J. Drummond Bone 2004, OECD-report 2004); and educational programmes in developing countries...... (Daniel et al. 2005, D'Antoni 2005). Concurrently sharing of knowledge and online community building in general are acknowledged as important drivers in informal learning processes, while online learning in formalized educations tend towards an increasing adoption of collaborative learning...... as the pedagogic frame (Laurillard 2002, Salmon 2003). However, as one major driver in the general adoption of online education is economy, yet another trend is to raise the volume of learners passing through any education pr. time unit....

  16. New thermodynamic measurements in the U-fe system

    Energy Technology Data Exchange (ETDEWEB)

    Labroche, D.; Dugne, O. [CEA Vallee du Rhone, Dept. de Technologie de l' Enrichissement, 26 - Pierrelatte (France); Rogez, J. [CTM, 13 - Marseille (France)

    2001-07-01

    The U-Fe phase diagram data from thermal measurements by Gordon, Grogan, Chapman and Michaud and from mass spectroscopic measurements by Gardie are generally in agreement. Two line compounds UFe{sub 2} and U{sub 6}Fe exist. The enthalpy of formation of UFe{sub 2} at 298 K is reported to be -32.4 kJ/mol by Akhachinskij, -61.8 kJ/mol by Kanno and -42.03 kJ/mol by Antony. This disagreement between the different authors requires some new measurements in order to improve the knowledge of this system. Moreover no data exists on the enthalpy of formation of U{sub 6}Fe and on the heat capacity of these two materials. The objective of this study is to measure these missing data in view of performing an assessment of the phase diagram. (author)

  17. 16th French-German-Polish Conference on Optimization

    CERN Document Server

    Korytowski, Adam; Maurer, Helmut; Szymkat, Maciej

    2016-01-01

    This book contains extended, in-depth presentations of the plenary talks from the 16th French-German-Polish Conference on Optimization, held in Kraków, Poland in 2013. Each chapter in this book exhibits a comprehensive look at new theoretical and/or application-oriented results in mathematical modeling, optimization, and optimal control. Students and researchers involved in image processing, partial differential inclusions, shape optimization, or optimal control theory and its applications to medical and rehabilitation technology, will find this book valuable. The first chapter by Martin Burger provides an overview of recent developments related to Bregman distances, which is an important tool in inverse problems and image processing. The chapter by Piotr Kalita studies the operator version of a first order in time partial differential inclusion and its time discretization. In the chapter by Günter Leugering, Jan Sokołowski and Antoni Żochowski, nonsmooth shape optimization problems for variational inequa...

  18. Une épuration ordinaire. Les procès des collaborateurs en Grèce (1944 - 1949 comme composante de la reconstruction judiciaire en Europe

    Directory of Open Access Journals (Sweden)

    Dimitris Kousouris

    2010-05-01

    Full Text Available Date de soutenance : le 3 avril 2009 à l’École des Hautes Études en Sciences Sociales, Paris.Jury de soutenanceFrançois Hartog (directeur de thèseKostas Kostis (Ecole des Hautes Etudes en Sciences SocialesJon Elster (Columbia University/Collège de FranceAntonis Liakos (Université d’AthènesEnzo Traverso (Université de Picardie.RésuméCette thèse porte sur l’histoire de l’épuration judiciaire des collaborateurs des forces d’occupation en Grèce après la libération du pays en 1944. Cette épur...

  19. [The proof of paternity. An andrological-forensic challenge in historical perspective].

    Science.gov (United States)

    Albrecht, K; Schultheiss, D

    2004-10-01

    For centuries, difficulties have occurred in determining unresolved paternities. In addition to the modern standard methods, such as the examination of DNA or serological proof, expert opinion on fertility once played an important role. The andrological difference between incapability to fertilise and the inability to participate in sexual intercourse was also distinguished historically. Of special significance was the discovery of spermatozoa by the medical student Johan Ham in 1677 and their further investigation by Antoni van Leeuwenhoek.Recently, modern DNA methods have also been applied for historical investigations. Illustrious examples are the DNA analysis in the case of Kaspar Hauser of Ansbach and the dispute about Thomas Jefferson, President of the U.S., fathering a child by one of his slaves. In this discourse, a medicinal-forensic review of the development of expert opinion, illustrated with historical case studies, is given.

  20. Jesuit strategy in Japan and India in the 16th Century as a precursor to modern Western “Soft Power”

    Directory of Open Access Journals (Sweden)

    Olga Vilenovna Volosyuk

    2017-12-01

    Full Text Available The principles of “soft power”, within the context of the historical development of international relations both on the worldwide and regional levels, had been applied in the East and in the West long before the aforementioned theories appeared. It was the Jesuits in the 16th Century who developed strategies of influence and were pioneers in the introduction of “soft” methods of leverage in international communication practice. In today’s world, which is witnessing an increase in the role of the religious factor in international relations, it is important to understand how to identify these achievements, and correct the mistakes of these early strategies, based on the practices of Francis Xavier in Japan and of Antoni de Montserrat in the Mughal Empire. An attentive and thorough study of the Jesuits’ experience is of great importance in understanding contemporary processes of international interaction from a “soft power” point of view.