Aloe vera on Lanzarote

OpenAIRE

Walker, Colin

2016-01-01

Aloe vera is the basis of a multibillion dollar cosmetics and toiletries industry worldwide. It is grown commercially in many parts of the world and here its cultivation is described on an aloe farm in the north of Lanzarote, the Canary Islands. The products from such monoculture are sold throughout the island in Aloe vera shops run principally by the company aloe Lanzarote.

Utilization of aloe vera extract as electrolyte for an accumulator

Science.gov (United States)

Azmi, F.; Sispriatna, D.; Ikhsan, K.; Masrura, M.; Azzahra, S. S.; Mahidin; Supardan, M. D.

2018-03-01

Aloe vera contains acid, which has the potential to generate electric current. The objective of this research is to study the potency of aloe vera extract as electrolyte for an accumulator. Experimental results showed that aloe vera extract has no a stable value of voltage and currency. The voltage and currency of aloe vera extract were reduced more than 50% for 60 minutes. Then, aloe vera extract was mixed with accu zuur to produce electrolyte solution. The mixture composition of aloe vera extract to accu zuur of 50:50 (v/v) generated stable voltage and currency. The experimental results showed the potential use of aloe vera extract to reduce the chemicals used in a conventional electrolyte solution.

Daya Hambat Ekstrak Aloe Vera terhadap pertumbuhan Staphylococcus Aureus

OpenAIRE

Rahmat, drg.Sp,Pros

2011-01-01

Dari hasil penelitian , maka dapat disimpulkan bahwa ekstrak Aloe Vera dapat menghambat pertumbuhan bakteri Stafhylococcus aureus, dan kadar hambat minimal ekstrak Aloe Vera adalah pada konsentrasi 25%. Tujuan Penelitan Ini adalah untuk mengetahui efektifitas ekstrak Aloe vera dalam menghambat pertumbuhan bakteri Stafhylococcus aureus dan daya hambat menimal, (DHM) terhadap pertumbuhan bakteri tersebut. Metode yang digunakan adalah pertumbuhan ekstrak Aloe vera, penegnceran ekstrak , pemur...

Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics

Directory of Open Access Journals (Sweden)

Edyta Lelonek

2018-02-01

Full Text Available Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus. The study group comprised 102 patients with molecularly confirmed polycythemia vera. Demographic data, data on disease history, polycythemia vera status and treatment modalities were collected. Moreover, various clinical features of aquagenic pruritus (including intensity, localization, quality, descriptors and the most common factors responsible for its aggravation or alleviation were examined. Aquagenic pruritus was observed in 41.2% of individuals, mean duration 6.6 ± 8.6 years, and its onset was noticed in the majority of patients (52.4% before the diagnosis of polycythemia vera. The mean intensity of aquagenic pruritus was 4.8 ± 1.9 points (visual analogue scale. One-third of patients with aquagenic pruritus avoided any contact with water. Antipruritic treatment was received only by 3 patients. Aquagenic pruritus seems to be an important, but frequently neglected, symptom in patients with polycythemia vera.

The experience of an United Nations Military Observer in Western Sahara / A experiência de observador militar da ONU no Saara Ocidental

Directory of Open Access Journals (Sweden)

Sylvio de Souza Ferreira

2017-03-01

Full Text Available The Western Sahara issue is the most recent, lasting and unresolved case of decolonization in African continent, in the midst of the 21st Century. It is a non- governed territory, located in the northwest portion of Saharan Africa and it has been under UN custody since 1991, when MINURSO had been established. In this regard, this article has as main motivation to communicate the experience of an UN Military Observer, emphasizing peculiar and practical aspects, as well as perceptions in the performance of this appointment. It is an internal vision of the reality of the Peace Operation, the individual and the professional of the UN. In order to do so, this article uses a qualitative approach deploying methodologies such as participant observation and the descriptive case study. It comprises an introduction, which aims to enlighten the reader to the question, a characterization of the area, a historical review of the case, a section of exposure of the methodology and the experience of one of the authors as a UN Military Observer in the Western Sahara itself. Finally, considerations are made at the conclusion. A questão do Saara Ocidental constitui o caso de descolonização mais recente, duradouro e não-resolvido do continente africano, em pleno século XXI. Trata-se de um território não-governado, localizado na porção noroeste da África Saariana e encontra-se sob custódia da ONU desde 1991, quando da implantação da MINURSO. Nesse contexto, o presente artigo tem como principal motivação comunicar a experiência no exercício da função de observador militar da ONU, sublinhando aspectos peculiares e práticos, bem como percepções no desempenho dessa função. É uma visão interna da realidade de uma Operação de Paz, do indivíduo e do profissional da Organização. Para tanto, o artigo utiliza abordagem qualitativa na metodologia empregada e aspectos da observação participante e do estudo de caso descritivo. É composto por uma

MC21/CTF and VERA multiphysics solutions to VERA core physics benchmark progression problems 6 and 7

Directory of Open Access Journals (Sweden)

Daniel J. Kelly, III

2017-09-01

Full Text Available The continuous energy Monte Carlo neutron transport code, MC21, was coupled to the CTF subchannel thermal-hydraulics code using a combination of Consortium for Advanced Simulation of Light Water Reactors (CASL tools and in-house Python scripts. An MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 6 demonstrated good agreement with MC21/COBRA-IE and VERA solutions. The MC21/CTF solution for VERA Core Physics Benchmark Progression Problem 7, Watts Bar Unit 1 at beginning of cycle hot full power equilibrium xenon conditions, is the first published coupled Monte Carlo neutronics/subchannel T-H solution for this problem. MC21/CTF predicted a critical boron concentration of 854.5 ppm, yielding a critical eigenvalue of 0.99994 ± 6.8E-6 (95% confidence interval. Excellent agreement with a VERA solution of Problem 7 was also demonstrated for integral and local power and temperature parameters.

POTENSI ANTI-HIPERKOLESTEROLEMIA EKASTRAK CASSIA VERA [Anti-hypercholesterolemic Potency of Cassia Vera (Cinnamomum burmanni Nees ex Blume Bark Extract

Directory of Open Access Journals (Sweden)

Fauzan Azima1

2004-08-01

Full Text Available There has been limited report on the phytochemical content of cassia vera bark extract, and its potency as anti-hypercholesterolemic in rabbit is not known yet. The objectives of this research was to determine the phytochemical content and potency of anti-hypercholesterolemic of cassia vera bark extract using rabbit as the animal model.The research was devided into three stages, namely: (1 preparing cassia vera extraction with ethanol 96%; (2 analyzing phytochemical contents of cassia vera bark extract; (3 in vivo experiment, where twenty New Zealand White rabbits aged 5 months were used. Experimental rabbits were divided into 5 groups. The rabbits were fed with atherogenic cholesterol (0.1% as positive control, RB11 standard feed as negative control, or cassia vera extracts (100 mg/kg/day or 200 mg/kg/day or fenofibrat (15 mg/day together with the atherogenic feed for 12 weeks. Levels of serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol were determined at 0, 4, 8, and 12 week. At the end of the experiment formation of fatty liver were observed. The results showed that the ethanol extract of cassia vera bark contains total phenol (62.25%, flavonoids, triterpenoid, saponin and alkaloid. On the other hand, cassia vera bark extract was able to decrease total serum cholesterol from 443.3 mg/dl to 139.1 mg/dl, LDL cholesterol from 286.5 mg/dl to 95.8 mg/dl and triglyceride from 122.2 mg/dl to 61.2 mg/dl. Meanwhile, it increased HDL serum cholesterol from 29.1 mg/dl to 50.0 mg/dl in rabbit. It was also shown that the extract was able to decrease the everage fat globule on liver significantly from 27.47 globule to 3.59 globule per field view. Cassia vera bark extract with phytochemical content was found to be potential as anti-hypercholesterolemic and also in preventing fatty liver formatonr in rabbit

Chorea disclosing a polycythemia vera

OpenAIRE

Liu, Guidong; Chang, Jie; Liu, Zhijun; Qiang, Qiang; Gu, Chunhui; Zhang, Yingying; Wei, Wenshi

2014-01-01

Guidong Liu, Jie Chang, Zhijun Liu, Qiang Qiang, Chunhui Gu, Yingying Zhang, Wenshi Wei Department of Neurology, Huadong Hospital, Fudan University, Shanghai, People's Republic of China Abstract: Chorea is a rare complication of polycythemia. We report the case of a 70 year-old woman whose polycythemia vera (PV), with Janus Kinase-2 (JAK2) mutation, presented as chorea. Chorea resolved quickly after hydroxyurea therapy. Keywords: chorea, polycythemia vera, elderly, JAK2

Aloe vera for treating acute and chronic wounds.

Science.gov (United States)

Dat, Anthony D; Poon, Flora; Pham, Kim B T; Doust, Jenny

2012-02-15

Aloe vera is a cactus-like perennial succulent belonging to the Liliaceae Family that is commonly grown in tropical climates. Animal studies have suggested that Aloe vera may help accelerate the wound healing process. To determine the effects of Aloe vera-derived products (for example dressings and topical gels) on the healing of acute wounds (for example lacerations, surgical incisions and burns) and chronic wounds (for example infected wounds, arterial and venous ulcers). We searched the Cochrane Wounds Group Specialised Register (9 September 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 3), Ovid MEDLINE (2005 to August Week 5 2011), Ovid MEDLINE (In-Process & Other Non-Indexed Citations 8 September 2011), Ovid EMBASE (2007 to 2010 Week 35), Ovid AMED (1985 to September 2011) and EBSCO CINAHL (1982 to 9 September 2011). We did not apply date or language restrictions. We included all randomised controlled trials that evaluated the effectiveness of Aloe vera, aloe-derived products and a combination of Aloe vera and other dressings as a treatment for acute or chronic wounds. There was no restriction in terms of source, date of publication or language. An objective measure of wound healing (either proportion of completely healed wounds or time to complete healing) was the primary endpoint. Two review authors independently carried out trial selection, data extraction and risk of bias assessment, checked by a third review author. Seven trials were eligible for inclusion, comprising a total of 347 participants. Five trials in people with acute wounds evaluated the effects of Aloe vera on burns, haemorrhoidectomy patients and skin biopsies. Aloe vera mucilage did not increase burn healing compared with silver sulfadiazine (risk ratio (RR) 1.41, 95% confidence interval (CI) 0.70 to 2.85). A reduction in healing time with Aloe vera was noted after haemorrhoidectomy (RR 16.33 days, 95% CI 3.46 to 77.15) and there was

Two Clinical Phenotypes in Polycythemia Vera

Science.gov (United States)

Spivak, Jerry L.; Considine, Michael; Williams, Donna M.; Talbot, Conover C.; Rogers, Ophelia; Moliterno, Alison R.; Jie, Chunfa; Ochs, Michael F.

2014-01-01

BACKGROUND Polycythemia vera is the ultimate phenotypic consequence of the V617F mutation in Janus kinase 2 (encoded by JAK2), but the extent to which this mutation influences the behavior of the involved CD34+ hematopoietic stem cells is unknown. METHODS We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correcting for potential confounding by sex, since the phenotypic features of the disease differ between men and women. RESULTS Men with polycythemia vera had twice as many up-regulated or down-regulated genes as women with polycythemia vera, in a comparison of gene expression in the patients and in healthy persons of the same sex, but there were 102 genes with differential regulation that was concordant in men and women. When these genes were used for class discovery by means of unsupervised hierarchical clustering, the 19 patients could be divided into two groups that did not differ significantly with respect to age, neutrophil JAK2 V617F allele burden, white-cell count, platelet count, or clonal dominance. However, they did differ significantly with respect to disease duration; hemoglobin level; frequency of thromboembolic events, palpable splenomegaly, and splenectomy; chemotherapy exposure; leukemic transformation; and survival. The unsupervised clustering was confirmed by a supervised approach with the use of a top-scoring-pair classifier that segregated the 19 patients into the same two phenotypic groups with 100% accuracy. CONCLUSIONS Removing sex as a potential confounder, we identified an accurate molecular method for classifying patients with polycythemia vera according to disease behavior, independently of their JAK2 V617F allele burden, and identified previously unrecognized molecular pathways in polycythemia vera outside the canonical JAK2 pathway that may be amenable to targeted therapy. PMID:25162887

Increased bone marrow blood flow in polycythemia vera

International Nuclear Information System (INIS)

Lathinen, R.; Lathinen, T.; Hyoedynmaa, S.

1983-01-01

Bone marrow blood flow was measured in polycythemia vera, in compensatory and in relative polycythemia with a 133 Xe washout method. In the treated polycythemia vera bone marrow blood flow was significantly increased compared with the age-matched controls. The fraction of blood flow entering the bone and flowing through the hematopoietic marrow was markedly increased in both the untreated and the treated polycythemia vera. Although the number of observations in compensatory and relative polycythemia was small, the results suggest that bone marrow blood flow is not markedly increased in these diseases. The results also suggest that in older patients the simple 133 Xe method may support the diagnosis of polycythemia vera. (orig.)

Increased bone marrow blood flow in polycythemia vera

Energy Technology Data Exchange (ETDEWEB)

Lathinen, R.; Lathinen, T.; Hyoedynmaa, S.

1983-01-01

Bone marrow blood flow was measured in polycythemia vera, in compensatory and in relative polycythemia with a /sup 133/Xe washout method. In the treated polycythemia vera bone marrow blood flow was significantly increased compared with the age-matched controls. The fraction of blood flow entering the bone and flowing through the hematopoietic marrow was markedly increased in both the untreated and the treated polycythemia vera. Although the number of observations in compensatory and relative polycythemia was small, the results suggest that bone marrow blood flow is not markedly increased in these diseases. The results also suggest that in older patients the simple /sup 133/Xe method may support the diagnosis of polycythemia vera.

Aloe vera extract activity on human corneal cells.

Science.gov (United States)

Woźniak, Anna; Paduch, Roman

2012-02-01

Ocular diseases are currently an important problem in modern societies. Patients suffer from various ophthalmologic ailments namely, conjunctivitis, dry eye, dacryocystitis or degenerative diseases. Therefore, there is a need to introduce new treatment methods, including medicinal plants usage. Aloe vera [Aloe barbadensis Miller (Liliaceae)] possesses wound-healing properties and shows immunomodulatory, anti-inflammatory or antioxidant activities. NR uptake, MTT, DPPH• reduction, Griess reaction, ELISA and rhodamine-phalloidin staining were used to test toxicity, antiproliferative activity, reactive oxygen species (ROS) reduction, nitric oxide (NO) and cytokine level, and distribution of F-actin in cells, respectively. The present study analyzes the effect of Aloe vera extracts obtained with different solvents on in vitro culture of human 10.014 pRSV-T corneal cells. We found no toxicity of ethanol, ethyl acetate and heptane extracts of Aloe vera on human corneal cells. No ROS reducing activity by heptane extract and trace action by ethanol (only at high concentration 125 µg/ml) extract of Aloe vera was observed. Only ethyl acetate extract expressed distinct free radical scavenging effect. Plant extracts decreased NO production by human corneal cells as compared to untreated controls. The cytokine (IL-1β, IL-6, TNF-α and IL-10) production decreased after the addition of Aloe vera extracts to the culture media. Aloe vera contains multiple pharmacologically active substances which are capable of modulating cellular phenotypes and functions. Aloe vera ethanol and ethyl acetate extracts may be used in eye drops to treat inflammations and other ailments of external parts of the eye such as the cornea.

The Virtual Environment for Reactor Applications (VERA): Design and architecture

International Nuclear Information System (INIS)

Turner, John A.; Clarno, Kevin; Sieger, Matt; Bartlett, Roscoe; Collins, Benjamin; Pawlowski, Roger; Schmidt, Rodney; Summers, Randall

2016-01-01

VERA, the Virtual Environment for Reactor Applications, is the system of physics capabilities being developed and deployed by the Consortium for Advanced Simulation of Light Water Reactors (CASL). CASL was established for the modeling and simulation of commercial nuclear reactors. VERA consists of integrating and interfacing software together with a suite of physics components adapted and/or refactored to simulate relevant physical phenomena in a coupled manner. VERA also includes the software development environment and computational infrastructure needed for these components to be effectively used. We describe the architecture of VERA from both software and numerical perspectives, along with the goals and constraints that drove major design decisions, and their implications. We explain why VERA is an environment rather than a framework or toolkit, why these distinctions are relevant (particularly for coupled physics applications), and provide an overview of results that demonstrate the use of VERA tools for a variety of challenging applications within the nuclear industry.

The Virtual Environment for Reactor Applications (VERA): Design and architecture

Energy Technology Data Exchange (ETDEWEB)

Turner, John A., E-mail: turnerja@ornl.gov [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Clarno, Kevin; Sieger, Matt; Bartlett, Roscoe; Collins, Benjamin [Oak Ridge National Laboratory, Oak Ridge, TN 37831 (United States); Pawlowski, Roger; Schmidt, Rodney; Summers, Randall [Sandia National Laboratories, Albuquerque, NM 87185 (United States)

2016-12-01

VERA, the Virtual Environment for Reactor Applications, is the system of physics capabilities being developed and deployed by the Consortium for Advanced Simulation of Light Water Reactors (CASL). CASL was established for the modeling and simulation of commercial nuclear reactors. VERA consists of integrating and interfacing software together with a suite of physics components adapted and/or refactored to simulate relevant physical phenomena in a coupled manner. VERA also includes the software development environment and computational infrastructure needed for these components to be effectively used. We describe the architecture of VERA from both software and numerical perspectives, along with the goals and constraints that drove major design decisions, and their implications. We explain why VERA is an environment rather than a framework or toolkit, why these distinctions are relevant (particularly for coupled physics applications), and provide an overview of results that demonstrate the use of VERA tools for a variety of challenging applications within the nuclear industry.

The new injection beamline at VERA

International Nuclear Information System (INIS)

Priller, Alfred; Melber, Karl; Forstner, Oliver; Golser, Robin; Kutschera, Walter; Steier, Peter; Wallner, Anton

2010-01-01

VERA has been operated for 12 years with one 40-cathode SNICS ion source. Since the number of isotopes investigated at VERA increased steadily, we decided to install a second ion source. Due to space restrictions, a new injection line had to be built and merged into the existing one. The major task was to build an electrostatic analyzer assembly to accommodate injection from two ion sources.

Initial Verification and Validation Assessment for VERA

Energy Technology Data Exchange (ETDEWEB)

Dinh, Nam [North Carolina State Univ., Raleigh, NC (United States); Athe, Paridhi [North Carolina State Univ., Raleigh, NC (United States); Jones, Christopher [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hetzler, Adam [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sieger, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-04-01

The Virtual Environment for Reactor Applications (VERA) code suite is assessed in terms of capability and credibility against the Consortium for Advanced Simulation of Light Water Reactors (CASL) Verification and Validation Plan (presented herein) in the context of three selected challenge problems: CRUD-Induced Power Shift (CIPS), Departure from Nucleate Boiling (DNB), and Pellet-Clad Interaction (PCI). Capability refers to evidence of required functionality for capturing phenomena of interest while capability refers to the evidence that provides confidence in the calculated results. For this assessment, each challenge problem defines a set of phenomenological requirements against which the VERA software is assessed. This approach, in turn, enables the focused assessment of only those capabilities relevant to the challenge problem. The evaluation of VERA against the challenge problem requirements represents a capability assessment. The mechanism for assessment is the Sandia-developed Predictive Capability Maturity Model (PCMM) that, for this assessment, evaluates VERA on 8 major criteria: (1) Representation and Geometric Fidelity, (2) Physics and Material Model Fidelity, (3) Software Quality Assurance and Engineering, (4) Code Verification, (5) Solution Verification, (6) Separate Effects Model Validation, (7) Integral Effects Model Validation, and (8) Uncertainty Quantification. For each attribute, a maturity score from zero to three is assigned in the context of each challenge problem. The evaluation of these eight elements constitutes the credibility assessment for VERA.

Cytotoxicity study of plant Aloe vera (Linn

Directory of Open Access Journals (Sweden)

Atul N Chandu

2012-01-01

Full Text Available Background: The objective of this study has been to evaluate the in-vitro antitumor activity of Aloe vera extract of in cultured B16F10 melanoma cell line by measuring cell viability using "Trypan blue exclusion assay" method. Aim: To find out such kind of anticancer drug which is a cheap, safe, less toxic, and more potent drug compared to chemotherapy drug. Materials and Methods: In-vitro antitumor activity cell culture1, drug treatment (standard and test extract and Trypan blue exclusion assay growth and viability test 1 were used. Treatment of Aloe vera extract against B16F10 melanoma cell line, in all concentration range, showed decrease in percent cell viability, as compared to that of negative when examined by "Trypan blue exclusion assay". Results: In overall variation of test samples, Aloe vera extract showed its best activity in the concentration of 300 μg/ml, which was approximately equal to the activity of standard drug doxorubicin. Evaluation of in-vitro antitumor activity revealed that Aloe vera extract exhibits good cytotoxic activity. The best cytotoxic activity by Aloe vera was shown at 200 μg/ml concentration. Conclusion: The study of cytoprotection against normal cells by micronucleus assay has shown that the herbal extracts have less toxic effects to the normal blood lymphocytes, as compared to that of standard anticancer drug.

Design, formulation and evaluation of Aloe vera chewing gum

Science.gov (United States)

Aslani, Abolfazl; Ghannadi, Alireza; Raddanipour, Razieh

2015-01-01

Background: Aloe vera has antioxidant, antiinflammatory, healing, antiseptic, anticancer and antidiabetic effects. The aim of the present study was to design and evaluate the formulation of Aloe vera chewing gum with an appropriate taste and quality with the indications for healing oral wounds, such as lichen planus, mouth sores caused by cancer chemotherapy and mouth abscesses as well as reducing mouth dryness caused by chemotherapy. Materials and Methods: In Aloe vera powder, the carbohydrate content was determined according to mannose and phenolic compounds in terms of gallic acid. Aloe vera powder, sugar, liquid glucose, glycerin, sweeteners and different flavors were added to the soft gum bases. In Aloe vera chewing gum formulation, 10% of dried Aloe vera extract entered the gum base. Then the chewing gum was cut into pieces of suitable sizes. Weight uniformity, content uniformity, the organoleptic properties evaluation, releasing the active ingredient in the phosphate buffer (pH, 6.8) and taste evaluation were examined by Latin square method. Results: One gram of Aloe vera powder contained 5.16 ± 0.25 mg/g of phenolic compounds and 104.63 ± 4.72 mg/g of carbohydrates. After making 16 Aloe vera chewing gum formulations, the F16 formulation was selected as the best formulation according to its physicochemical and organoleptic properties. In fact F16 formulation has suitable hardness, lack of adhesion to the tooth and appropriate size and taste; and after 30 min, it released more than 90% of its drug content. Conclusion: After assessments made, the F16 formulation with maltitol, aspartame and sugar sweeteners was selected as the best formulation. Among various flavors used, peppermint flavor which had the most acceptance between consumers was selected. PMID:26605214

Fungi associated with base rot disease of aloe vera (Aloe ...

African Journals Online (AJOL)

STORAGESEVER

2008-12-17

Dec 17, 2008 ... full base rot disease after 6 days of inoculation. Key words: Fungi, base rot, Aloe vera. INTRODUCTION. Aloe barbadensis Miller, popularly called Aloe vera is a phanerogame angiosperm which belongs to the family. Liliaceae. The plant is a perennial drought resistant succulent plant (Figure 1). Aloe vera is ...

Juan H. Vera and Grazyna Wilczek-Vera: Classical Thermodynamics of Fluid Systems: Principles and Applications. CRC Press, Taylor & Francis Group

DEFF Research Database (Denmark)

Kontogeorgis, Georgios

2017-01-01

The book Classical Thermodynamics of Fluid Systems: Principles and Applications written by professor Juan H. Vera and Dr. Grazyna Wilczek-Vera is undoubtably a book written in a most personal style by the two distinguished authors.The book contains four sections and a fifth one with appendices...

Hypoglycemic effect of instant aloe vera on the diabetic rats

Directory of Open Access Journals (Sweden)

Riyanto

2017-09-01

Full Text Available Instant aloe vera contains phenolic compounds which has antioxidative activity. However, this product is hygroscopic and damaged easily during storage. The critical condition of the instant occurs at the moisture content of 12.52 ± 0.24% (wb. Increasing the moisture content could accelerate oxidation of the phenolic compounds, thus decrease the antioxidative activity. Previous research showed that the antioxidative activity of instant aloe vera could lower the blood glucose. The purpose of this study was to evaluate the hypoglycemic activity of instant aloe vera during storage until the critical condition. The hypoglycemic effect was determined with the in vivo method using diabetic Wistar rats as experimental animals. The diabetic rats were fed with a standard feed combined with instant aloe vera which has been stored at various storage time i.e. 0, 2, 4, 6, 8 weeks and used normal rats fed without instant aloe vera as a control. The blood glucose was analyzed every week until 4 weeks. The research showed that the diabetic rats fed with standard feed without instant aloe vera had high blood glucose (219.40 mg/dL after 4 weeks treatment. Otherwise, the blood glucose of diabetic rats fed with instant aloe vera decreased from 214.00 mg/dL to 97.57 mg/dL after 4 weeks.

Polycythemia vera among participants of a nuclear weapons test

International Nuclear Information System (INIS)

Sobell, J.L.; Codd, M.B.; Silverstein, M.N.; Kurland, L.T.

1987-01-01

Three letters-to-the-editors discuss the finding of a statistically significant excess of polycythemia vera cases among participants in the Smoky detonation. Had population-based incidence rates from Rochester been used to derive an expected incidence, and had only bona fide polycythemia vera cases been considered, as is the rule in most epidemiologic studies, the observed frequency of polycythemia vera among participants in the Smoky test would have been found to be well within chance expectations

Antifungal activity of aloe vera gel against plant pathogenic fungi

International Nuclear Information System (INIS)

Sitara, U.; Hassan, N.; Naseem, J.

2011-01-01

Aloe vera gel extracted from the Aloe vera leaves was evaluated for their antifungal activity at the rate of 0.15%, 0.25% and 0.35% concentration against five plants pathogenic fungi viz., Aspergillus niger, Aspergillus flavus, Alternaria alternata, Drechslera hawaiensis and Penicillum digitatum 0.35% concentration Aloe vera gel completely inhibited the growth of Drechslera hawaiensis and Alternaria alternata. (author)

Formulation and Characterization of Aceclofenac -Aloe vera Transemulgel.

Science.gov (United States)

Raju, Y Prasanna; Haritha, K; Satyanarayana, Rao P; Vandana, K R; Bindu, D Thushara; Vinesha, V; Chowdary, V Harini

2015-01-01

The present research was aimed to formulate aceclofenac transemulgel using Aloe vera as gel base. The prepared formulations were subjected to physical characterization, in-vitro and in-vivo assessment. Aceclofenac, a hydrophobic potential non steroidal anti inflammatory drug, causes ulceration upon chronic oral administration, could be formulated into transemulgel to enhance therapeutic efficacy and to lower the unwanted side effects. The transemulgel was prepared from aqueous Aloe vera gel and aceclofenac emulsion. The prepared transemulgel was evaluated for its pH, viscosity, drug content, skin irritation, in-vitro diffusion and accelerated stability studies. The prepared aceclofenac-Aloe vera tranemulgel and commercial aceclofenac gel were subjected to pharmacodynamic studies in albino rats of Wistar strain employing carrageenan induced left hind paw edema method to assess the anti-inflammatory effect. The transemulgel showed a pH of 6.78 and viscosity of 18 cps. In-vitro diffusion data revealed better permeation characteristics. Topical application of formulation found no skin irritation. Stability study has proved the integrity of the formulation. The prepared aceclofenac Aloe vera transemulgel showed better in-vitro drug release when compared with the commercial aceclofenac gel formulation. Anti-inflammatory activity in treated rats showed the significant paw volume reduction at pAloe vera as gel base.

Ecological observations on the Indian Spiny-tailed Lizard Saara hardwickii (Gray, 1827 (Reptilia: Squamata: Agamidae in Tal Chhapar Wildlife Sanctuary, Rajasthan, India

Directory of Open Access Journals (Sweden)

S.K. Das

2013-01-01

Full Text Available Observations on the Indian Spiny-tailed Lizard Saara hardwickii (Gray, 1827 were undertaken in Tal Chhapar Wildlife Sanctuary, Rajasthan, India during the monsoons (July following quadrat sampling that was time-constrained. The study revealed that the area is one of the preferable habitats for the species. A population analysis showed that the relative abundance of the subadults was higher, followed by juveniles and adults during the study period. The beginning of activity of the lizards was found to vary over the study period depending on prevailing weather conditions. The activity pattern was bimodal, except across rain events. The study revealed two important ecological findings about these lizards; complete sealing of burrow during rains which differed from partial sealing on normal days and complete diurnal cycle of body colour changes during the monsoon. Feeding was the predominant activity of this lizard followed by basking, resting and chasing each other. The adult lizards were found to be strictly herbivorous, in spite of an abundance of insects available in the area during the period. Subadults and juveniles were found to eat both plant parts, as well as insects. Microhabitat use such as inside grass clumps was found to be higher followed by barren ground, under shade and on stones.

Efficient protocol for rapid Aloe vera micropropagation.

Science.gov (United States)

Molsaghi, Mozhgan; Moieni, Ahmad; Kahrizi, Danial

2014-06-01

Aloe vera Linn. (Liliaceae) is a medicinal plant and has a number of curative properties. Vegetative propagation has not enough potential for supplying market demand. However, via in vitro propagation makes possible the mass production of Aloe plants. The current study was conducted to investigate growth regulators' effects on proliferation of A. vera. In this study, for comparison of plant growth regulators' effects on proliferation, the shoot tips and auxiliary buds of A. vera were cultured in the Murashige and Skoog (MS) medium. Rooted plantlets were transferred to garden soil, compost, and sand in the proportion of 1:1:1, respectively, after hardening. The maximum number of shoots was obtained on the medium supplemented with 1 mg/L IAA+4 mg/L BAP and 0.2 mg/L IAA+0.8 BAP mg/L. Rooting was also achieved in the same media composition proliferation of shoot. The acclimatized plants showed 100% of survival. The regenerated plants looked healthy, and they were morphologically similar to that of stock plants. These results suggest that in vitro culture may be used as a technique for rapid propagation of A. vera.

Qualitative improvement of low meat beef burger using Aloe vera.

Science.gov (United States)

Soltanizadeh, Nafiseh; Ghiasi-Esfahani, Hossein

2015-01-01

Low meat beef burgers have found their niche in the food markets in developing countries because of their lower price. However, these burgers still lack an acceptable quality. This study investigates the effects of different concentrations of Aloe vera on the quality of this food product. For this purpose, beef burgers were produced with 0%, 1%, 3%, and 5% Aloe vera and the changes in their cooking parameters, lipid oxidation, texture, and appeal to consumers over 7days of refrigerated storage were evaluated. Results indicate that Aloe vera contributed to some extent to decreased cooking loss and diameter reduction in the burgers. Increased concentrations of Aloe vera led to improvements in the water absorption and texture of the burgers as well as their lipid stability. However, a concentration level of 3% led to the most acceptability of the product to the panelists. Finally, it was found that Aloe vera acts as a hydrocolloid and improves the quality of burgers. Copyright © 2014 Elsevier Ltd. All rights reserved.

Quality change of apple slices coated with Aloe vera gel during storage.

Science.gov (United States)

Song, Hye-Yeon; Jo, Wan-Shin; Song, Nak-Bum; Min, Sea C; Song, Kyung Bin

2013-06-01

Fresh-cut apples are easily susceptible to browning and microbial spoilage. In this study, an edible coating prepared from Aloe vera gel containing antibrowning solution was applied to preserve the quality of fresh-cut apples during storage. Fresh-cut apples were treated with both an Aloe vera gel and an Aloe vera gel containing 0.5% cysteine and then stored at 4 °C for 16 d. The color, firmness, weight loss, soluble solid content, titratable acidity, microbial analysis, and sensory evaluation were analyzed during storage. Fresh-cut apples coated with the Aloe vera gel showed delayed browning and reduced weight loss and softening compared to the control. The Aloe vera gel coating was also effective in reducing the populations of the total aerobic bacteria and yeast and molds. In particular, Aloe vera gel containing 0.5% cysteine was most effective in delaying browning and the reduction of microbial populations among the treatments. These results suggest that an Aloe vera gel coating can be used for maintaining the quality of fresh-cut apples. © 2013 Institute of Food Technologists®

All we know about polycythemia vera: literature review and own experience

Directory of Open Access Journals (Sweden)

K. M. Abdulkadyrov

2015-01-01

Full Text Available The literature review and own long-term polycythemia vera diagnosis and treatment experience are presented in this article. The results of newest advances in pathogenesis description, modern diagnostic techniques and treatment modalities in polycythemia vera are included. The JAK-STAT signal pathway activation now recognized as main pathogenesis mechanism of polycythemia vera. In this case this activation caused almost exlusively by JAK2 gene mutations. Authors demonstrate their own data about epidemiology, clinical signs and diagnostic and treatment results of 252 polycythemia vera patients. The most frequent clinical symptoms at diagnosis were: plethora, headache and dizziness, fatigue, pruritus. Diagnostic criteria and thrombotic complications prognostic scale are presented. The thrombosis frequency in this polycythemia vera patients group was 11.1 %. It was included 3.6 % of myocardial infarctions and 5.2 % of strokes. The thrombotic complications rates statistically differed in various prognostic groups. For example, from 2.6 % in low-risk group to 20.6 % in high-risk thrombosis group. The used personalized polycythemia vera management algorithm is listed. The treatment methods features, target drugs (Janus kinases inhibitors trials results are discussed.

The effect of aloe vera on ischemia--Reperfusion injury of sciatic nerve in rats.

Science.gov (United States)

Guven, Mustafa; Gölge, Umut Hatay; Aslan, Esra; Sehitoglu, Muserref Hilal; Aras, Adem Bozkurt; Akman, Tarik; Cosar, Murat

2016-04-01

Aloe vera is compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of aloe vera treatment in rats with experimental sciatic nerve ischemia/reperfusion injury. Twenty-eight male Wistar Albino rats were divided equally into 4 groups. Groups; Control group (no surgical procedure or medication), sciatic nerve ischemia/reperfusion group, sciatic nerve ischemia/reperfusion+aloe vera group and sciatic nerve ischemia/reperfusion+methylprednisolone group. Ischemia was performed by clamping the infrarenal abdominal aorta. 24 hours after ischemia, all animals were sacrificed. Sciatic nerve tissues were also examined histopathologically and biochemically. Ischemic fiber degeneration significantly decreased in the pre-treated with aloe vera and treated with methylprednisolone groups, especially in the pre-treated with aloe vera group, compared to the sciatic nerve ischemia/reperfusion group (paloe vera group was not statistically different compared to the MP group (p>0.05). Aloe vera is effective neuroprotective against sciatic nerve ischemia/reperfusion injury via antioxidant and anti-inflammatory properties. Also aloe vera was found to be as effective as MP. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Watts Bar Unit 2 Startup Results with VERA

Energy Technology Data Exchange (ETDEWEB)

Godfrey, Andrew T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Collins, Benjamin S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Gentry, Cole A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ritchie, John A. [Tennessee Valley Authority (TVA), Knoxville, TN (United States)

2017-03-01

CASL members TVA, Westinghouse, and Oak Ridge National Laboratory have successfully completed a detailed simulation of the initial startup of Watts Bar Nuclear Unit 2 (WBN2) using the advanced reactor simulation tools known as VERA. WBN2 is the first commercial power reactor to join the nation’s electrical grid in over two decades, and the modern core design and availability of data make it an excellent benchmark for CASL. Calculations were performed three months prior to the startup, and in the first blind application of VERA to a new reactor, predicted criticality and physics parameters very close to those later measured by TVA. Subsequent calculations with the latest version of VERA and using exact measurement conditions improved the results even further.

The Effects of Crude Aqueous and Alcohol Extracts of Aloe Vera on ...

African Journals Online (AJOL)

The gastrointestinal tract of neonates is sensitive to dietary manipulations. When nursing mothers use Aloe vera, their babies are at risk of indirect exposure to Aloe vera via breast feeding or directly as health supplements. The effects of orally administered extracts of Aloe vera in unweaned rats were investigated. Six day ...

Aloe vera for prevention and treatment of infusion phlebitis.

Science.gov (United States)

Zheng, Guo Hua; Yang, Liu; Chen, Hai Ying; Chu, Jian Feng; Mei, Lijuan

2014-06-04

Up to 80% of hospitalised patients receive intravenous therapy at some point during their admission. About 20% to 70% of patients receiving intravenous therapy develop phlebitis. Infusion phlebitis has become one of the most common complications in patients with intravenous therapy. However, the effects of routine treatments such as external application of 75% alcohol or 50% to 75% magnesium sulphate (MgSO4) are unsatisfactory. Therefore, there is an urgent need to develop new methods to prevent and alleviate infusion phlebitis. To systematically assess the effects of external application of Aloe vera for the prevention and treatment of infusion phlebitis associated with the presence of an intravenous access device. The Cochrane Peripheral Vascular Diseases Group Trials Search Co-ordinator (TSC) searched the Specialised Register (last searched February 2014) and CENTRAL (2014, Issue 1). In addition the TSC searched MEDLINE to week 5 January 2014, EMBASE to Week 6 2014 and AMED to February 2014. The authors searched the following Chinese databases until 28 February 2014: Chinese BioMedical Database; Traditional Chinese Medical Database System; China National Knowledge Infrastructure; Chinese VIP information; Chinese Medical Current Contents; Chinese Academic Conference Papers Database and Chinese Dissertation Database; and China Medical Academic Conference. Bibliographies of retrieved and relevant publications were searched. There were no restrictions on the basis of date or language of publication. Randomised controlled trials (RCTs) and quasi-randomised controlled trials (qRCTs) were included if they involved participants receiving topical Aloe vera or Aloe vera-derived products at the site of punctured skin, with or without routine treatment at the same site. Two review authors independently extracted the data on the study characteristics, description of methodology and outcomes of the eligible trials, and assessed study quality. Data were analysed using RevMan 5

In vitro activity of Aloe vera inner gel against Helicobacter pylori strains.

Science.gov (United States)

Cellini, L; Di Bartolomeo, S; Di Campli, E; Genovese, S; Locatelli, M; Di Giulio, M

2014-07-01

Aloe barbadensis Miller (Aloe vera) is a herbal remedy widely used for a variety of illnesses; A. vera leaf extracts have been promoted for detoxification, cure constipation, help flush out toxins and wastes from the body, promote digestion and are used in the treatment of peptic ulcer for cytoprotective action. The aim of this study was to evaluate the antibacterial activity of A. vera inner gel against both susceptible and resistant Helicobacter pylori strains isolated in Abruzzo region, Italy. The inner gel of leaves of a 5-year-old plant of A. vera was extracted, homogenized and tested from 800 to 1.56 mg ml(-1) against 14 clinical strains and one reference strain of H. pylori using the broth microdilution methodology. Furthermore, the sample of A. vera was investigated for the chemical fingerprint of anthraquinones. The inhibitory concentrations of A. vera inner gel were similar to the bactericidal ones, with values ranging from 6.25 to 800 mg ml(-1) . Fifty per cent of the detected strains, independently of their susceptibility profile, were inhibited in their growth at 100 mg ml(-1) . Aloe vera inner gel expresses antibacterial properties against H. pylori and, therefore, in combination with antibiotics, could represent a novel strategy for the treatment of the infection of H. pylori, especially in cases of multiresistance. The study demonstrates that the Aloe vera inner gel expresses antibacterial properties against both susceptible and resistant Helicobacter pylori strains. These findings may impact on the antimicrobial resistance phenomenon of H. pylori, proposing the A. vera inner gel as a novel effective natural agent for combination with antibiotics for the treatment of H. pylori gastric infection. © 2014 The Society for Applied Microbiology.

Effectivity of Aloe vera bioactives as feed additive for broilers reared on deep litter

Directory of Open Access Journals (Sweden)

A.P Sinurat

2004-10-01

Full Text Available There are plenty of Indonesian plants contain usefull bioactive components. One of them is Aloe vera. Previous experiment showed that Aloe vera bioactives reduced aerob bacteria in the intestinal and improved feed efficiency in broilers reared in cages. The results however, gave some variations, may be due to variation in rearing the chickens. Two experiments were carried out to study the effectivity of Aloe vera bioactives as feed additives for broilers reared on deep litter. In the first study, six experimental diets in mash form were formulated, i.e.: Control (K; K + antibiotic; K + 0.50 g/kg dry Aloe vera (LBK; K + 1.00 g/kg LBK; K + anthraquinone; K + Aloe vera in semi-liquid form. The amount of semi liquid Aloe vera and the anthraquinone were equally to 1.00 g LBK/kg. Results showed that antibiotic improved body weight gain 6.10% and feed efficiency 5.50% better than the control, although statistically not significant (P>0.05. Aloe vera bioactives in low doses (0.50 g/kg also improved weight gain (6.30% and feed efficiency (5.20% similar to the antibiotic. However, Aloe vera in high doses and anthraquinone (equal to 1.00 g/kg diet did not improve performance of broilers. There were no significant changes on carcass yield, abdominal fat levels, weight of liver, gizard and gastro intestinal tract due to any feed additives tested. The second experiment were carried out to study the effectivity of feed additives when included in crumble diets. Six experimental diets, i.e.: Control (K, K + antibiotic, K + Semi-liquid Aloe vera (equal to 1.00g dry Aloe vera/kg, K + 0.50 g dry Aloe vera/kg, K + 1.00 g dry Aloe vera/kg, K + 0.50 g dry Aloe vera + 0.50 g Curcuma xanthorrhiza meal/kg. All diets were fed in crumble form. Results showed that chickens fed with feed additives (antibiotic or Aloe vera bioactives have a significantly (P<0.05 higher body weight gain and feed efficiency than those fed with control diet. The best weight gain was achieved by

Objective high Resolution Analysis over Complex Terrain with VERA

Science.gov (United States)

Mayer, D.; Steinacker, R.; Steiner, A.

2012-04-01

VERA (Vienna Enhanced Resolution Analysis) is a model independent, high resolution objective analysis of meteorological fields over complex terrain. This system consists of a special developed quality control procedure and a combination of an interpolation and a downscaling technique. Whereas the so called VERA-QC is presented at this conference in the contribution titled "VERA-QC, an approved Data Quality Control based on Self-Consistency" by Andrea Steiner, this presentation will focus on the method and the characteristics of the VERA interpolation scheme which enables one to compute grid point values of a meteorological field based on irregularly distributed observations and topography related aprior knowledge. Over a complex topography meteorological fields are not smooth in general. The roughness which is induced by the topography can be explained physically. The knowledge about this behavior is used to define the so called Fingerprints (e.g. a thermal Fingerprint reproducing heating or cooling over mountainous terrain or a dynamical Fingerprint reproducing positive pressure perturbation on the windward side of a ridge) under idealized conditions. If the VERA algorithm recognizes patterns of one or more Fingerprints at a few observation points, the corresponding patterns are used to downscale the meteorological information in a greater surrounding. This technique allows to achieve an analysis with a resolution much higher than the one of the observational network. The interpolation of irregularly distributed stations to a regular grid (in space and time) is based on a variational principle applied to first and second order spatial and temporal derivatives. Mathematically, this can be formulated as a cost function that is equivalent to the penalty function of a thin plate smoothing spline. After the analysis field has been divided into the Fingerprint components and the unexplained part respectively, the requirement of a smooth distribution is applied to the

Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis.

Science.gov (United States)

Alam, Sarwar; Ali, Iqbal; Giri, K Y; Gokkulakrishnan, S; Natu, Subodh S; Faisal, Mohammad; Agarwal, Anshita; Sharma, Himanshu

2013-12-01

Definitive therapy is not defined for the management of oral submucous fibrosis (OSMF). This study evaluated the efficacy of aloe vera gel as an adjuvant treatment of OSMF. A double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted on 60 subjects with OSMF divided into medicinal treatment (submucosal injection of hyaluronidase and dexamethasone, n = 30) and surgical treatment (n = 30) categories. Each category was randomly divided into groups A (with aloe vera, n = 15 per category) and B (without aloe vera, n = 15 per category). Follow-up assessment for various symptoms was performed, and results were analyzed using paired and unpaired Student t tests. The group receiving aloe vera had a significant improvement in most symptoms of OSMF (P aloe vera group, in both the medicinal and surgical categories. Aloe vera gel was effective as an adjuvant in treatment of OSMF. Copyright © 2013 Elsevier Inc. All rights reserved.

Rapid micro-propagation of Aloe vera L. via shoot multiplication

African Journals Online (AJOL)

STORAGESEVER

2008-06-17

. Cloning protocol of Aloe vera as a study-case for tailor- made biotechnology to small farmers. J. Technol. Manag. Innov. 1: 76-79. Debiasi C, Silva CG, Pescador R (2007). Micropropagation of Aloe vera. L., Rev. Bras. PIant.

Síndrome de Sweet associada à policitemia vera

OpenAIRE

Moreira,Ângela Puccini; Souza,Flávia Feijó de; Gaspar,Neide Kalil; Quattrino,Ada Lobato; Vilar,Enoi Aparecida Guedes

2009-01-01

A síndrome de Sweet pode estar associada a malignidades hematológicas, principalmente, à leucemia mieloide aguda, porém existem poucos relatos demonstrando a associação com a policitemia vera. Relata-se o caso de doente do sexo masculino, de 65 anos, portador de policitemia vera,que evoluiu com aparecimento de síndrome de Sweet na sua forma paraneoplásica.

Protective effects of Aloe vera-based diets in Eimeria maxima-infected broiler chickens.

Science.gov (United States)

Yim, Dongjean; Kang, Sang S; Kim, Dong W; Kim, Sang H; Lillehoj, Hyun S; Min, Wongi

2011-01-01

Aloes have been widely used for a broad range of pharmacological activities, including parasitic problems. Avian coccidiosis is the most costly and wide-spread parasitic disease in the poultry industry, and has been mainly controlled by the use of chemotherapeutic agents. Due to the emergence of drug-resistant strains, alternative control strategies are needed. In this study, the protective effects of Aloe vera-based diets were assessed in broiler chickens following oral infection with Eimeria maxima. Chickens were fed a regular diet supplemented with ground Aloe vera throughout the duration of the experiment beginning 2 days prior to infection with 1 × 10(4) sporulated oocysts of E. maxima. No significant differences were found in body weight gain or loss between the Aloe vera-supplemented and unsupplemented groups with or without E. maxima infections. Fecal oocyst shedding decreased significantly (p vera as compared to the unsupplemented group. Furthermore, the Aloe vera-supplemented group showed significantly fewer intestinal lesions (p vera could be used an alternative treatment for controlling avian coccidiosis. Copyright © 2010 Elsevier Inc. All rights reserved.

Variation in Phytochemical Composition Reveals Distinct Divergence of Aloe vera (L.) Burm.f. From Other Aloe Species: Rationale Behind Selective Preference of Aloe vera in Nutritional and Therapeutic Use

Science.gov (United States)

Dey, Priyankar; Dutta, Somit; Chowdhury, Anurag; Das, Abhaya Prasad; Chaudhuri, Tapas Kumar

2017-01-01

In the present study, we have phytochemically characterized 5 different abundant Aloe species, including Aloe vera (L.) Burm.f., using silylation followed by Gas Chromatography-Mass Spectrometry technique and compared the data using multivariate statistical analysis. The results demonstrated clear distinction of the overall phytochemical profile of A vera, highlighted by its divergent spatial arrangement in the component plot. Lowest correlation of the phytochemical profiles were found between A vera and A aristata Haw. (−0.626), whereas highest correlation resided between A aristata and A aspera Haw. (0.899). Among the individual phytochemicals, palmitic acid was identified in highest abundance cumulatively, and carboxylic acids were the most predominant phytochemical species in all the Aloe species. Compared to A vera, linear correlation analysis revealed highest and lowest correlation with A aspera (R 2 = 0.9162) and A aristata (R 2 = 0.6745), respectively. Therefore, A vera demonstrated distinct spatial allocation, reflecting its greater phytochemical variability. PMID:29228808

Fast Dissolving Tablets of Aloe Vera Gel | Madan | Tropical Journal ...

African Journals Online (AJOL)

Purpose: The objective of this work was to prepare and evaluate fast dissolving tablets of the nutraceutical, freeze dried Aloe vera gel. Methods: Fast dissolving tablets of the nutraceutical, freeze-dried Aloe vera gel, were prepared by dry granulation method. The tablets were evaluated for crushing strength, disintegration ...

Symbiotics and Aloe vera and Symphytum officinale extracts in broiler feed

Directory of Open Access Journals (Sweden)

Paula Rodrigues Oliveira

2016-09-01

Full Text Available This study aimed to test the effects of dietary Aloe vera and Symphytum officinale extracts added separately or in combination with symbiotics on the performance, nutrient utilization, serum biochemical parameters, biometrics, and intestinal histomorfometry of broilers. The experiment had a randomized block design with five treatments and six replicates of ten broilers each. Treatments were as follows: negative control and positive control (diet without and with antibiotic, respectively; 0.2% Aloe vera (AV; 0.2% Symphytum officinale (S; 0.2% functional supplement, composed of symbiotics fermented in Aloe vera and comfrey plant extracts (S+PE. At seven days of age, FI of birds fed the Aloe vera extracts diets were lower than that observed for birds consuming the diet with Symphytum officinale extract and S+PE. Broiler performance remained unaffected by treatments at others ages evaluated. At 10 to 14 days of age the lowest ADCDM ADCCP was shown in group feed NC. The highest ADCCP was observed in PC control group and in diets supplemented with Aloe vera and S+PE. Serum levels of cholesterol, triglycerides, and phosphorus were affected by addition of extracts at seven, 21, and 35 days of age. The longest duodenal villi were observed in broilers fed S+PE diets at seven days of age. Aloe vera and Symphytum officinale extracts and symbiotics can be used in broiler diets as an alternative to growth-promoting antibiotics.

Stimulation of osteoblast activity by induction of Aloe vera and xenograft combination

Directory of Open Access Journals (Sweden)

Utari Kresnoadi

2011-12-01

Full Text Available Background: Tooth extraction is generally followed by alveolar ridge resorption that later can cause flat ridge. Aloe vera have biogenic stimulator and hormone activities for wound healing. Purpose: This study was aimed to know osteoblast activities in alveolar bone after induction of Aloe vera and XCB combination. Methods: Fifty four of Cavia cabaya were divided into three main groups. Group I was control group. Group II was filled with xenograft concelous bovine (XCB and group III was filled with the combination of Aloe vera gel and XCB. Then, each group was divided into three sub groups according to timing, they are 14, 30, and 60 days after tooth extraction and application. Histology and morphology examination were performed on the harvested specimens. Results: There were significant differences between the control group and the other groups filled with the combination of Aloe vera and XCB. Conclusion: In conclusion, the application of Aloe vera gel and xenograft combination decrease the number of osteoclast and increase the number of osteoblast in post tooth extraction alveolar bone structure indicating the new growth of alveolar bone.Latar belakang: Pencabutan gigi pada umumnya selalu diikuti resopsi tulang alveolar, sehingga bila terjadi dalam waktu yang lama ridge akan menjadi flat. Aloe vera adalah bahan stimulasi biogenik dan mempunyai aktivitas hormon untuk proses penyembuhan luka. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui aktivitas osteoblas pada tulang alveol dengan pemberian kombinasi Aloe vera gel dan xenograft concelous bovine (XCB. Metode: Lima puluh empat ekor Cavia cabaya, dibagi menjadi 3 kelompok besar, kelompok pertama adalah kelompok kontrol yaitu hanya dilakukan pencabutan saja tanpa perlakuan, kelompok ke-2 yaitu kelompok yang setelah dicabut diberi XCB saja dan kelompok ke-3 yaitu kelompok yang setelah pencabutan diberi kombinasi Aloe vera gel dengan XCB pada luka bekas pencabutan gigi. Kemudian masing

Hypoglycemic and Hypolipidemic Effects of Aloe vera Extract Preparations: A Review.

Science.gov (United States)

Pothuraju, Ramesh; Sharma, Raj Kumar; Onteru, Suneel Kumar; Singh, Satvinder; Hussain, Shaik Abdul

2016-02-01

Obesity is considered to be an epidemic disease, and it is associated with several metabolic disorders. Pharmacological treatments currently available are not effective for prolonged treatment duration. So, people are looking toward new therapeutic approach such as herbal ingredients. Since ancient periods, different herbs have been used for remedy purposes such as anti-obesity, antidiabetes, and antiinflammatory. Among the several herbal ingredients, Aloe vera (Aloe barbadensis Miller) is widely used to curb the metabolic complications. Till date, reports are not available for the side effects of A. vera. Several researchers are used to different solvents such as aqueous solution, alcohol, ethanol, and chloroform for the A. vera extract preparations and studied their hypoglycemic and hypolipidemic effects in animal and human studies. Furthermore, little information was recorded with the active compounds extracted from the A. vera and their anti-obesity and antidiabetic effects in clinical studies. In this review, we made an attempt to compile all the available literature by using different search engines (PubMed, Scopus, and Google Scholar) on the A. vera extract preparations and the possible mechanism of action involved in carbohydrate and lipid metabolism. Copyright © 2015 John Wiley & Sons, Ltd.

Protective role of Aloe vera against X-ray induced testicular dysfunction.

Science.gov (United States)

Bala, S; Chugh, N A; Bansal, S C; Garg, M L; Koul, A

2017-09-01

The present investigation was carried out to evaluate the possible radioprotective potential of an Aloe vera extract against whole-body X-ray irradiation-induced testicular alterations in mice. Male balb/c mice were divided into four groups: control, A. vera, X-ray and A. vera pre-treated + X-ray irradiated. Histopathological examination revealed significant structural alterations in testes after X-ray exposure, which was also associated with the presence of apoptotic cells as assessed by TUNEL assay. X-ray irradiation resulted in elevation in the levels of reactive oxygen species, lipid peroxidation, a reduction in glutathione concentration and enhanced activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase and glutathione-S-transferase. Sperm count/motility and testosterone levels were significantly decreased in the irradiated group. Irradiated animals pre-treated with A. vera extract revealed an improvement in antioxidant status, inhibition of lipid peroxides, apoptotic cell formation and enhanced testicular parameters when compared to the X-ray-exposed group. These findings suggest that A. vera extract could ameliorate X-ray-induced damage due to its free radical scavenging properties and its potential to boost cellular antioxidant defence machinery. © 2016 Blackwell Verlag GmbH.

Síndrome de Sweet associada à policitemia vera

OpenAIRE

Moreira, Ângela Puccini; Souza, Flávia Feijó de; Gaspar, Neide Kalil; Quattrino, Ada Lobato; Vilar, Enoi Aparecida Guedes

2009-01-01

A síndrome de Sweet pode estar associada a malignidades hematológicas, principalmente, à leucemia mieloide aguda, porém existem poucos relatos demonstrando a associação com a policitemia vera. Relata-se o caso de doente do sexo masculino, de 65 anos, portador de policitemia vera,que evoluiu com aparecimento de síndrome de Sweet na sua forma paraneoplásica. Sweet’s syndrome may be associated with hematological malignancies, particularly with acute myelogenous leukemia, but there are few rep...

Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study

Science.gov (United States)

Rezazadeh, Fahimeh; Moshaverinia, Maryam; Motamedifar, Mohammad; Alyaseri, Montazer

2016-01-01

Statement of the Problem Herpes simplex virus (HSV) infection is one of the most common and debilitating oral diseases; yet, there is no standard topical treatment to control it. The extract of Aloe vera leaves has been previously reported to have anti-inflammatory, antibacterial, and also antiviral effects. There is no data on anti-Herpes simplex virus type 1 (HSV-1) activity of Aloe vera gel. Purpose This study aimed to evaluate the anti-HSV-1 activity of Aloe vera gel in Vero cell line. Materials and Method In this study, gel extraction and cytotoxicity of various increasing concentrations of Aloe vera gel (0.2, 0.5, 1, 2, and 5%) was evaluated in Dulbecco’s Modified Eagle Medium (DMEM) containing 2% fetal bovine serum (FBS). Having been washed with phosphate buffered saline, 50 plaque-forming units (PFU) of HSV-1 was added to each well. After 1 hour of incubation at 37°C, cell monolayers in 24 well plates were exposed to different increasing concentrations of Aloe vera gel. The anti-HSV-1 activity of Aloe vera gel in different concentrations was assessed by plaque reduction assays. Data were analyzed by using One-way ANOVA. Results The cytotoxicity assay showed that Aloe vera in prearranged concentrations was cell-compatible. The inhibitory effect of various concentrations of Aloe vera was observed one hour after the Vero cell was infected with HSV-1. However, there was no significant difference between two serial concentrations (p> 0.05). One-way ANOVA also revealed no significant difference between the groups. The findings indicated a dose-dependent antiviral effect of Aloe vera. Conclusion The findings showed significant inhibitory effect of 0.2-5% Aloe vera gel on HSV-1 growth in Vero cell line. Therefore, this gel could be a useful topical treatment for oral HSV-1 infections without any significant toxicity. PMID:26966709

Scintigraphy of the bone marrow with 111In-citrin in polycythemia vera

International Nuclear Information System (INIS)

Prikhod'ko, A.G.; Sheptun, A.N.; Vikman, Ya.Eh.; Sorokin, I.N.; Rozdil'skij, S.I.; Zabobonina, L.V.

1986-01-01

Scintigraphy of the bone marrow with 111 In-citrin was performed in 32 patients with polycythemia vera and 8 controls. The method ensured an objective assessment of bone marrow function in patients with polycythemia vera. A characteristic RP scintigraphic picture corresponded to different clinical stages of the disease. A degree of a decrease in the blood radioactivity within 24 h after i.v. administration of 111 In-citrin reflected the summary erythropoietic activity of the bone marrow and could serve as a differential diagnostic criterion in determining a stage of polycythemia vera

Dietary Aloe vera supplementation on growth performance, some haemato-biochemical parameters and disease resistance against Streptococcus iniae in tilapia (GIFT).

Science.gov (United States)

Gabriel, Ndakalimwe Naftal; Qiang, Jun; He, Jie; Ma, Xin Yu; Kpundeh, Mathew D; Xu, Pao

2015-06-01

This study investigated effects of dietary Aloe vera on growth performance, some haemato-biochemical parameters and disease resistance against Streptococcus iniae in tilapia (GIFT). Five groups were designed including a basal diet (control) and 100% A. vera powder incorporated in fish feed at 0.5% 1%, 2%, and 4%/kg feed, which were administered for 8 weeks. Fish fed 0.5%, 1%, and 2% A. vera supplemented diet significantly improved (p vera diet at 1% and 2%/kg feed. Feed efficiency ratio, feed conversion ratio, and hepatosomatic index were significantly enhanced in 4% A. vera supplemented fish over unsupplemented ones (p vera supplemented fish showed a significant increase (p vera supplemented fish showed a decrease (p vera diet at 2% and 4% A. vera/kg feed than those fed unsupplemented diet. Unchallenged fish fed 0.5%, 1%, and 2% A. vera showed significantly higher values (p vera supplemented diet. There was a significant increase (p vera unsupplemented fish and those supplemented with A. vera diet at 1%/kg feed increased significantly (p vera supplemented diet maintained higher values at all experimental stages among groups. There was a significant correlation (p Aloe had no significant effect (p > 0.05) on the survival of the fish when compared to the control; no mortality was recorded in challenge trial. Overall, our results indicated that dietary aloe supplementation could improve growth, feed utilization, and haemato-biochemical parameters of cultured tilapia. Copyright © 2015 Elsevier Ltd. All rights reserved.

Long-term monitoring of Sgr A* at 7 mm with VERA and KaVA

Science.gov (United States)

Akiyama, K.; Kino, M.; Sohn, B.; Lee, S.; Trippe, S.; Honma, M.

2014-05-01

We present the results of radio monitoring observations of Sgr A* at 7 mm (i.e. 43 GHz) with the VLBI Exploration of Radio Astrometry (VERA), which is a VLBI array in Japan. VERA provides angular resolution on millisecond scales, resolving structures within 100 Schwarzschild radii of Sgr A* , similar to the Very Large Baseline Array (VLBA). We performed multi-epoch observations of Sgr A* in 2005 - 2008, and started monitoring it again with VERA from 2013 January to trace the current G2 encounter event. Our preliminary results in 2013 show that Sgr A* on mas scales has been in an ordinary state as of August 2013, although some fraction of the G2 cloud already passed the pericenter of Sgr A* in April 2013. We will continue monitoring Sgr A* with VERA and the newly developed KaVA (KVN and VERA Array).

Assessment of the Safety of Aqueous Extract of Aloe vera on ...

African Journals Online (AJOL)

Aloe vera is used both traditionally and packaged commercially in many regions of the world for several medicinal and or cosmetic purposes. It is claimed to have rejuvenating, moisturizing, healing or soothing properties on the skin and gastrointestinal tract. This study focused on assessment of the safety of A. vera on blood ...

The effect of aqueous Aloe vera gel extract on serum mineral ...

African Journals Online (AJOL)

This study was conducted to determine the effect of Aloe vera gel extract on the serum mineral compositions of Red Sokoto bucks. Blood samples were collected from 30 bucks before the commencement of administration of Aloe vera gel extract for serum minerals and these served as control group. The bucks were now ...

Evaluation of free radical scavenging and radioprotective efficacy of Aloe vera extract

International Nuclear Information System (INIS)

Chakrawarti, Aruna; Purohit, R.K.; Agarwal, Manisha; Ranga, Anita; Saran, Leena

2012-01-01

Radiation induced damage and lethality to the normal tissues can be partially reduced by the use of radio-protectors that lower down the damaging effects of radiation. In the present study radio-protective effect of Aloe vera extract which is rich in vitamins. It is basically cellular regenerator and therefore acts, with very positive results in many conditions. It is reported to have antioxidant, anti carcinogenic, antimicrobial and immunity stimulants properties. For the present experiment, healthy Swiss albino mice (6-8 weeks old) were selected and maintained under standard conditions of temperature and light. Aloe vera juice was fed orally at the dose rate of 0.01 m1/animal/day. The animals were divided into seven groups according to the treatment given to them i.e. given cadmium chloride solution as drinking water (group-II) or exposed to 5.0 Gy gamma radiations (group-III) or combined treatment of radiation and cadmium chloride (group-IV). The alterations in the biochemical parameters of all these group were compared with that of sham irradiated animals (group-I). The animals of experimental groups were given Aloe vera seven days prior to radiation or cadmium chloride treatment (group-V, VI and VII) respectively. All biochemical parameters of the control groups were compared with the respective experimental groups. An increase in the value of total proteins, glycogen, acid and alkaline phosphatase activity and RNA was observed up to day-14 in the non drug treated group and day-7 in the Aloe vera groups. Thereafter value declined up to day-28 without reaching to the normal. Whereas the value of cholesterol and DNA showed a decreasing trend up to day-14 in non drug treated groups and day-7 in Aloe vera treated groups. Thus it showed that cadmium and radiation produced toxic effect on kidney and Aloe vera minimize these effects. Protection offered by Aloe vera may be due to the scavenging or oxidizing free radicals. Thus it can be concluded that Aloe vera may

Aloe vera-based formula as emollient on horses' hooves

Directory of Open Access Journals (Sweden)

Samuel Pereira Simonato

2013-06-01

Full Text Available The present study aimed at developing an Aloe vera-based formula for topical use on horse hoof and evaluating whether the treatment affects hooves growth and balance. Six healthy male horses between the ages of 3 and 17 years (12±5.25 were used, all semi-confined animals for breeding purposes. Before beginning A. vera treatment, animals underwent two trimming procedures with a 45 days-interval. After the second trimming, one of the forelimbs and one of the hindlimbs of 4 horses was weekly treated by topical application of the glycolic extract of A. vera at 20%. The contralateral limb, randomly chosen, received the extract at 50%. The hooves of the other animals were treated with propylene glycol. Treatment was done for 225 days and, during this time, animals underwent periodic trimming. Variables related to growth and balance of the hooves were measured before and after trimming. Data were analyzed using chi-square test and regression analysis at 5% significance. Growth rate of the hooves was not related to treatment. On the other hand, the 50% extract was related to the majority of the hooves in balance (p<0.05. Results suggest that a weekly topical treatment with A. vera glycolic extract does not improve the growth rate of the hooves; however, when applied at a high concentration, it improves their balance.

Automated Control of the Organic and Inorganic Composition of Aloe vera Extracts Using (1)H NMR Spectroscopy.

Science.gov (United States)

Monakhova, Yulia B; Randel, Gabriele; Diehl, Bernd W K

2016-09-01

Recent classification of Aloe vera whole-leaf extract by the International Agency for Research and Cancer as a possible carcinogen to humans as well as the continuous adulteration of A. vera's authentic material have generated renewed interest in controlling A. vera. The existing NMR spectroscopic method for the analysis of A. vera, which is based on a routine developed at Spectral Service, was extended. Apart from aloverose, glucose, malic acid, lactic acid, citric acid, whole-leaf material (WLM), acetic acid, fumaric acid, sodium benzoate, and potassium sorbate, the quantification of Mg(2+), Ca(2+), and fructose is possible with the addition of a Cs-EDTA solution to sample. The proposed methodology was automated, which includes phasing, baseline-correction, deconvolution (based on the Lorentzian function), integration, quantification, and reporting. The NMR method was applied to 41 A. vera preparations in the form of liquid A. vera juice and solid A. vera powder. The advantages of the new NMR methodology over the previous method were discussed. Correlation between the new and standard NMR methodologies was significant for aloverose, glucose, malic acid, lactic acid, citric acid, and WLM (P vera.

A Comparison between Antibacterial Activity of Propolis and Aloe vera on Enterococcus faecalis (an In Vitro Study).

Science.gov (United States)

Ehsani, Maryam; Amin Marashi, Mahmood; Zabihi, Ebrahim; Issazadeh, Maryam; Khafri, Soraya

2013-01-01

Removing the bacteria, including Enterococcus faecalis, from the root canal is one of the important aims in endodontic treatment.We aimed to compare the antibacterial activity of Chlorhexidine with two natural drugs. The antibacterial activities of three different propolis extracts (alcohol concentrations: 0, 15, 40%) and Aloe vera gel on E. faecalis were compared using three methods: disk diffusion, microdilution and direct contact test. In addition to the above bacterium, the Aloe vera gel effect on Staphylococcus aureus and Streptococcus mutans was evaluated. Disk diffusion test revealed that propolis ethanolic extracts (the alcohol concentration of 15 and 40%) and Aloe vera gel have antibacterial activities but aqueous extract of propolis did not show any effect in this test. The MICs for propolis ethanolic extracts, Aloe vera gel and aqueous extract of propolis (0% alcohol) were 313 µg/ml, 750 µg/ml, 2250 µg/ml, and ≥ 500 µg/ml respectively, much higher than the Chlorhexidine one. In direct contact test, contrary to Aloe vera, all three propolis extracts showed antibacterial effects on E. faecalis. The Aloe vera gel also showed significant antibacterial effect on S.aureus and S.mutans. The hydroalcoholic extracts of propolis and Aloe vera gel had antibacterial effects on E. faecalis, however, propolis is more potent than Aloe vera. The antibacterial effect of Aloe vera on S. aureus and S. mutans is low (MIC ≥ 2250 µg/ml). Appropriate concentrations of alcoholic extracts of propolis and some fractions of Aloe vera gel might be good choices for disinfecting the root canal in endodontic treatments.

Vera Brittain: feminism and pacifism in post-war Britain

OpenAIRE

Sánchez Sánchez, Cristina

2016-01-01

Trabajo de fin de Grado. Grado en Estudios Ingleses. Curso académico 2015-2016 [EN]This paper deals with Vera Brittain's Testament of Youth as an example of war narrative to establish the importance of the female voice in the complete treatment of a story, as well as the importance of a feminist and pacifist ideology in a modern world. Vera Brittain thus becomes a relevant figure in these fields, considering several aspects of her life: her autobiography, her experience as ...

Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice.

Science.gov (United States)

Rathor, Naveen; Arora, Tarun; Manocha, Sachin; Patil, Amol N; Mediratta, Pramod K; Sharma, Krishna K

2014-03-01

The effect of Aloe vera in epilepsy has not yet been explored. This study was done to explore the effect of aqueous extract of Aloe vera leaf powder on three acute and one chronic model of epilepsy. In acute study, aqueous extract of Aloe vera leaf (extract) powder was administered in doses 100, 200 and 400 mg/kg p.o. Dose of 400 mg/kg of Aloe vera leaf extract was chosen for chronic administration. Oxidative stress parameters viz. malondialdehyde (MDA) and reduced glutathione (GSH) were also estimated in brain of kindled animals. In acute study, Aloe vera leaf (extract) powder in a dose-dependent manner significantly decreased duration of tonic hind limb extension in maximal electroshock seizure model, increased seizure threshold current in increasing current electroshock seizure model, and increased latency to onset and decreased duration of clonic convulsion in pentylenetetrazole (PTZ) model as compared with control group. In chronic study, Aloe vera leaf (extract) powder prevented progression of kindling in PTZ-kindled mice. Aloe vera leaf (extract) powder 400 mg/kg p.o. also reduced brain levels of MDA and increased GSH levels as compared to the PTZ-kindled non-treated group. The results of study showed that Aloe vera leaf (extract) powder possessed significant anticonvulsant and anti-oxidant activity. © 2013 Royal Pharmaceutical Society.

Parque eólico offshore playas de Vera

OpenAIRE

Morales Sánchez, Daniel

2016-01-01

Propiamente la redacción de este proyecto tiene como objeto los siguientes puntos: • La descripción de las obras e instalaciones necesarias para llevar a cabo la construcción del Parque Eólico Offshore Vera. • Servir de soporte técnico para la obtención de la Autorización Administrativa y la Aprobación del Proyecto de construcción y la puesta en marcha del Parque Eólico Offshore Vera. • Dicho proyecto será extremadamente respetuoso con el entorno, cumpliendo en todo momento con la D...

SINTESIS MEMBRAN NATA ALOE VERA-ETILENDIAMIN DAN KARAKTERISASINYA

Directory of Open Access Journals (Sweden)

EB Susatyo

2014-06-01

Full Text Available Serat yang terkandung di dalam nata Aloe vera adalah selulosa sehingga dapat digunakan dalam sintesis membran. Telah dilakukan penelitian tentang sintesis membran nata Aloe vera-etilendiamin (nata-en menggunakan sistem vakum cair. Proses preparasi membran berlangsung melalui tiga tahap, yaitu preparasi nata Aloe vera, aktivasi menggunakan asam sulfat, dan modifikasi dengan menggunakan etilendiamin. Tujuan penelitian adalah untuk mempelajari teknik dalam sintesis membran nata-en kemudian melakukan karakterisasi untuk mengetahui karakter strukturnya. Hasil penelitian menunjukkan perilaku yang berbeda dalam hal sifat mekanik dan strukturnya. Membran nata murni memiliki sifat mekanik yang kuat, nata teraktivasi cenderung rapuh, sedangkan nata-en bersifat liat. Spektra infra merah dari ketiga tipe membran (nata murni, nata teraktivasi, dan nata-en secara umum tidak mengalami perubahan yang signifikan, hanya terjadi pergeseran panjang gelombang dari masing-masing membran. Berdasarkan spektra infra merah dapat diketahui bahwa masing-masing membran mempunyai gugus hidroksil, tetapi serapannya semakin melebar untuk setiap membran. Gugus alkil dan karboksil juga masih tampak, namun pada membran nata teraktivasi serapannya berkurang, sedangkan pada membran nata-en muncul puncak baru yang menunjukkan adanya gugus amin. Hal ini membuktikan bahwa telah terjadi ikatan antara nata dengan etilendiamin. Fibers contained in nata Aloe vera is cellulose that can be used in the synthesis of membrane. The research has done on the synthesis of nata Aloe vera-ethylenediamine (nata-en membrane by using liquid vacuum system. Membrane preparation process consisted of three stages, they are nata Aloe vera preparation, activation using sulfuric acid, and membrane modification by using ethylenediamine. The purpose of research is to study the technique of nata-en membrane synthesis then to perform the characterization to determine the character of their structure.The results

Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review.

Science.gov (United States)

Dhingra, K

2014-04-01

To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting clinical, microbiological, immunological, and patient-centered data for the efficacy of aloe vera herbal dentifrices for controlling plaque and gingival inflammation in patients with gingivitis. From 79 titles and abstracts, eight full-text articles were screened and finally two randomized controlled trials were selected. These randomized controlled trials reported that aloe vera dentifrices were similar in efficacy to control dentifrices in effectively reducing plaque and gingival inflammation in gingivitis patients based on the assessment of clinical, microbiological, and patient-centered treatment outcomes. However, many important details (composition and characteristics of aloe vera and control dentifrices along with appropriate randomization, blinding, and outcomes assessed) were lacking in these trials, and therefore, the quality of reporting and methods was generally flawed with high risk of bias. Even though there are some promising results, the clinical effectiveness of aloe vera herbal dentifrices is not sufficiently defined at present and warrants further investigations based on reporting guidelines of herbal CONSORT statement. © 2013 John Wiley & Sons A/S.

Review of Bison Usage in VERA

Energy Technology Data Exchange (ETDEWEB)

Gardner, Russell [Idaho National Lab. (INL), Idaho Falls, ID (United States); Pawlowski, Roger P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Clarno, Kevin T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-11-01

Bison is being used in VERA in a variety of ways; this milestone will document an independent review of the current usage of Bison and provide guidance that will improve the accuracy, performance, and consistency in the ways that Bison is used. This task will entail running a suite of small, single and multi-cycle problems with VERA-CS, followed by Bison, and Tiamat (inline) and evaluating the usage. It will also entail performing several detailed ramp to full power solutions to compare the one-way coupled solver with the fully-coupled Tiamat. This will include at least one iteration with the PHI team to incorporate some of the feedback and improve the usage. This work will also be completed in conjunction with an FMC task to evaluate the ability of Bison to model load-follow in a PWR

Analysis of Aloe vera cytotoxicity and genotoxicity associated with endodontic medication and laser photobiomodulation.

Science.gov (United States)

Carvalho, Nayane Chagas; Guedes, Simone Alves Garcez; Albuquerque-Júnior, Ricardo Luiz Cavalcanti; de Albuquerque, Diana Santana; de Souza Araújo, Adriano Antunes; Paranhos, Luiz Renato; Camargo, Samira Esteves Afonso; Ribeiro, Maria Amália Gonzaga

2018-01-01

This study aims to evaluate, in vitro, the effect of Aloe vera associated with endodontic medication, with or without laser photobiomodulation (FTL) irradiation in FP6 human pulp fibroblasts. The materials were divided into eight groups: CTR - control; CL - FTL alone; AA - Aloe vera with distilled water; AL - Aloe vera with distilled water and FTL; HA - calcium hydroxide P.A. with distilled water; HL - calcium hydroxide P.A. with distilled water and FTL; HAA - calcium hydroxide P.A. with Aloe vera and distilled water; HAL - calcium hydroxide P.A. with Aloe vera, distilled water, and FTL. The cytotoxicity was evaluated by MTT assay at 24, 48, and 72h and the genotoxicity by micronucleus test assay. This study was performed in triplicate. Data obtained in both tests were statistically analyzed by ANOVA and Tukey's tests (p≤0.05). Group AA presented high genotoxicity and low cytotoxicity. After 24, 48, and 72h, the group HAA significantly reduced the cell viability. Interaction with FTL showed slightly increase cell viability after 24 and 48h in groups CL and HL (pAloe vera allowed higher cell viability in human pulp fibroblasts in the presence of calcium hydroxide or with FTL separately, but genotoxicity increased in these associations. Copyright © 2017 Elsevier B.V. All rights reserved.

The effect of aloe vera bioactive level as feed additive on the egg performances of laying hens

Directory of Open Access Journals (Sweden)

I.A.K Bintang

2005-06-01

Full Text Available A study on the use of aloe vera bioactives as feed additive in layer ration was conducted. One hundred and twenty pullets strain Isa Brown were allocated into 5 treatments with 6 replicates and 4 birds/replicate. The treatments were: control,control+antibiotic (50 ppm zinc bacitracin, and control+ aloe vera at three levels (0.25; 0.50 and 1.00 g/kg. The treatments were conducted in a completely randomized design. Parameter measured were first initial body weight, age at 1st lay, feed intake, egg weight, hen day (%HD and feed conversion ratio. The results showed that antibiotic and aloe vera used as additive for 9 months production did not significantly (P<0.05 affect all parameter measured, except feed intake of hens fed diet containing 0.5 g/kg aloe vera was significantly (P<0.05 higher than control. The addition of aloe vera at 1.0 g/kg significantly (P<0.05 reduced the feed intake as compared with the control, aloe vera 0.25 and 0.50 g/kg. The used of aloe vera (1.00 g/kg produced egg weight significantly (P<0.05 higher than the control, and feed conversion ratio was significantly (P<0.05 better than the control and aloe vera (0.25 g/kg. It is concluded that the best treatment was the diet with aloe vera level at 1.00 g/kg. This treatment improved feed efficiency 8.40%.

Holistic Healing Through Herbs: Effectiveness of Aloe Vera on Post Extraction Socket Healing.

Science.gov (United States)

Nimma, Vijaya Lakshmi; Talla, Harsha Vardhan; Bairi, Jaya Krishna; Gopaldas, Madhulatha; Bathula, Haritha; Vangdoth, Sandeep

2017-03-01

Advances in the field of alternative medicine has encouraged the use of various natural products for multiple uses in the field of dentistry for treatment of various oral diseases. A natural herbal product is Aloe vera, which has number of benefits with no reported side effects and gaining considerable importance in clinical research. The aim of this cross-sectional randomized interventional study was to evaluate the effectiveness of Aloe vera in the healing of post extraction sockets. A sample size of 40 patients undergoing atraumatic extraction was divided into two groups. Group A-patients were prescribed only analgesics and followed for seven consecutive days and socket healing assessment was done. Group B-Patients were given Aloe vera soaked gel foams, followed up to the third and seventh day by two observers and the socket healing was assessed using the standardized index by Landry, Turnbull and Howley. In addition to healing the common complaint associated with extraction wound, the pain was assessed using numerical rating scale. Data obtained was statistically analysed using Mann-whitney U test, Wilcoxon Signed ranks test and Spearman's rank correlation method. Control group on the third and the seventh day showed healing of 60% and 70% respectively and the Aloe vera group showed a better result having a healing potential of 70% on the third day and 90% on the seventh day which was statistically significant with a (p-valueAloe vera group showed a significant decrease in pain after two hours on the day of extraction followed by second, third and seventh day which was statistically significant (p-valueAloe vera has been proved to have a unique property that is implicated in better healing than other group without any side effects. Aloe vera is economical, effective, powerful nutritional supplement and antioxidant that protects and promotes wound healing.

Holistic Healing Through Herbs: Effectiveness of Aloe Vera on Post Extraction Socket Healing

Science.gov (United States)

Talla, Harsha Vardhan; Bairi, Jaya Krishna; Gopaldas, Madhulatha; Bathula, Haritha; Vangdoth, Sandeep

2017-01-01

Introduction Advances in the field of alternative medicine has encouraged the use of various natural products for multiple uses in the field of dentistry for treatment of various oral diseases. A natural herbal product is Aloe vera, which has number of benefits with no reported side effects and gaining considerable importance in clinical research. Aim The aim of this cross-sectional randomized interventional study was to evaluate the effectiveness of Aloe vera in the healing of post extraction sockets. Materials and Methods A sample size of 40 patients undergoing atraumatic extraction was divided into two groups. Group A-patients were prescribed only analgesics and followed for seven consecutive days and socket healing assessment was done. Group B-Patients were given Aloe vera soaked gel foams, followed up to the third and seventh day by two observers and the socket healing was assessed using the standardized index by Landry, Turnbull and Howley. In addition to healing the common complaint associated with extraction wound, the pain was assessed using numerical rating scale. Data obtained was statistically analysed using Mann-whitney U test, Wilcoxon Signed ranks test and Spearman’s rank correlation method. Results Control group on the third and the seventh day showed healing of 60% and 70% respectively and the Aloe vera group showed a better result having a healing potential of 70% on the third day and 90% on the seventh day which was statistically significant with a (p-valueAloe vera group showed a significant decrease in pain after two hours on the day of extraction followed by second, third and seventh day which was statistically significant (p-valueAloe vera has been proved to have a unique property that is implicated in better healing than other group without any side effects. Aloe vera is economical, effective, powerful nutritional supplement and antioxidant that protects and promotes wound healing. PMID:28511517

[GPC Fingerprint Chromatograms of Aloe vera Leaf Gel Polysaccharides].

Science.gov (United States)

Wang, Qiao-e; Xie, Dan; Qian, Jie; Dong, Yin-mao

2015-10-01

To establish the gel permeation chromatography (GPC) fingerprint chromatograms of polysaccharides in Aloe vera leaf gel from the same habitat (Beijing) and different habitats for evaluating the quality of Aloe vera leaf gel products commercially available and testing common adulterated substances. The samples were prepared by water-extraction and alcohol-precipitation method. GPC separation was performed on a Shodex SUGAR KS-805 (300 mm x 8.0 mm, 7 μm) column and a Shodex SUGAR KS-803 (300 mm x 8.0 mm, 6 μm) column at the temperature of 60 degrees C by eluting with 0.1 mol/L NaNO3 (containing 0.2 per thousand NaN) at a flow rate of 0.8 mL/min, the chromatographic effluent was detected by refractive index detector (RID) at the temperature of 50 degrees C. The common pattern of GPC fingerprint chromatograms was established and four common peaks were demarcated. The similarities of samples from the same habitat (Beijing) and different habitats were over 0.9. Taking the GPC fingerprint chromatograms for the qualified model, three commercially available aloe products were evaluated to be made of Aloe vera by the different manufacturing processes and four common adulterated substances of aloe polysaccharides were identified effectively. The method is simple and accurate with a good reproducibility, and it can be used for the identification and quality evaluation of Aloe vera leaf gel products.

Influence of Aloe vera on water absorption and enzymatic in vitro degradation of alginate hydrogel films.

Science.gov (United States)

Pereira, Rúben F; Carvalho, Anabela; Gil, M H; Mendes, Ausenda; Bártolo, Paulo J

2013-10-15

This study investigates the influence of Aloe vera on water absorption and the in vitro degradation rate of Aloe vera-Ca-alginate hydrogel films, for wound healing and drug delivery applications. The influence of A. vera content (5%, 15% and 25%, v/v) on water absorption was evaluated by the incubation of the films into a 0.1 M HCl solution (pH 1.0), acetate buffer (pH 5.5) and simulated body fluid solution (pH 7.4) during 24h. Results show that the water absorption is significantly higher for films containing high A. vera contents (15% and 25%), while no significant differences are observed between the alginate neat film and the film with 5% of A. vera. The in vitro enzymatic degradation tests indicate that an increase in the A. vera content significantly enhances the degradation rate of the films. Control films, incubated in a simulated body fluid solution without enzymes, are resistant to the hydrolytic degradation, exhibiting reduced weight loss and maintaining its structural integrity. Results also show that the water absorption and the in vitro degradation rate of the films can be tailored by changing the A. vera content. Copyright © 2013 Elsevier Ltd. All rights reserved.

Multiple myeloma on polycythemia vera following radioactive phosphorus therapy

International Nuclear Information System (INIS)

West, W.O.

1976-01-01

A 74-year-old white man with established polycythemia vera was treated with radioactive phosphorus after phlebotomies alone failed to control his disease. About 2 3 / 4 years later he died of multiple myeloma. The mutagenic effect of radioactive phosphorus may have caused or possibly accelerated preexisting myeloma. Basic nonmalignant disease deserves careful consideration before radiation or radiomimetic agents are used. One might consider a probably less mutagenic drug such as hydroxyurea in patients with polycythemia vera when phlebotomy alone does not give good control of red cell mass and thrombocytosis

Aloe vera gel and cesarean wound healing; a randomized controlled clinical trial.

Science.gov (United States)

Molazem, Zahra; Mohseni, Fatemeh; Younesi, Masoumeh; Keshavarzi, Sareh

2014-08-31

Failure in complete healing of the wound is one of the probable complications of cesarean. The present study aimed to determine the effectiveness of dressing with aloe vera gel in healing of cesarean wound. This prospective randomized double-blind clinical trial was conducted on 90 women who had undergone cesarean operation in Amir-al-Momenin hospital (Gerash, Iran). The participants were randomly divided into two groups each containing 45 patients. In one group, the wound was dressed with aloe vera gel, while simple dressing was used in the control group. Wound healing was assessed 24 hours and 8 days after the cesarean operation using REEDA scale. The data were analyzed through Chi-square and t-test. The participants' mean age was 27.56±4.20 in the aloe vera group and 26.62±4.88 in the control group, but the difference was not statistically significant. However, a significant difference was found between the two groups concerning body mass index, heart rate, and systolic blood pressure (Paloe vera group and 35 ones in the control group had obtained a zero score 24 hours after the operation. These measures were respectively obtained as 42 and 41eight days after the operation. According to the findings of this study, the women are recommended to be informed regarding the positive effects of dressing with aloe vera gel.

SYNTHESIS AND CHARACTERIZATION OF BIODEGRDABLE PLASTIC FROM CASAVA STARCH AND ALOE VERA EXTRACT WITH GLYCEROL PLASTICIZER

Directory of Open Access Journals (Sweden)

Mery Apriyani

2016-05-01

Full Text Available Synthesis and characterizations of Biodegradable Plastic made of Cassava Waste Starch, glycerol, acetic acid and Aloe vera extract has done. The aims of this research are to study the influence of addition of aloe vera extract in plastics mechanics properties, water vapor transmission rate and biodegradation. There are five main steps in this research, extraction of aloe vera, cassava starch preparation from cassava waste, preparations, characterization and biodegradability study of biodegradable plastic. The addition variations of aloe vera extract that used in this research are 0.01; 0.03; 0.05; 0.07 and 0.14 grams. Results showed that the addition of aloe Vera tends to increased biodegrable plastic thickness to 0.01 mm and elongation to 32.07%. However, biodegradable plastic tensile strength tends to decreased to 23.95 Mpa. Optimum tensile strength is 3.90 Mpa and elongation is 34.43%. Optimum water vapor transmission rate is 2.40 g/m2hours. Biodegradation study of biodegradable plastic showed that addition of aloe vera extract doesn’t significantly influence in plastic degradations.

The effects of Aloe vera [gel] on clotting time, prothrombin time and ...

African Journals Online (AJOL)

Background: Published reports on the effects of Aloe vera gel on blood coagulation in experimental animals are relatively scanty. Aim: To determine the effect of Aloe vera gel on clotting time, prothrombin time and plasma fibrinogen concentration in albino Wistar rats. Methods: A total of 28 adult albino Wistar rats divided ...

Diffusion of hydroxyl ions from calcium hydroxide and Aloe vera pastes.

Science.gov (United States)

Batista, Victor Eduardo de Souza; Olian, Douglas Dáquila; Mori, Graziela Garrido

2014-01-01

This study evaluated the diffusion through the dentinal tubules of hydroxyl ions from different calcium hydroxide (CH) pastes containing Aloe vera. Sixty single-rooted bovine teeth were used. The tooth crowns were removed, the root canals were instrumented and the specimens were assigned to 4 groups (n=15) according to the intracanal medication: Group CH/S - CH powder and saline paste; Group CH/P - CH powder and propylene glycol paste; Group CH/A - calcium hydroxide powder and Aloe vera gel paste; Group CH/A/P - CH powder, Aloe vera powder and propylene glycol paste. After placement of the root canal dressings, the teeth were sealed coronally and apically with a two-step epoxy adhesive. The teeth were placed in identified flasks containing deionized water and stored in an oven with 100% humidity at 37 °C. After 3 h, 24 h, 72 h, 7 days, 15 days and 30 days, the deionized water in the flasks was collected and its pH was measured by a pH meter. The obtained data were subjected to statistical analysis at a significance level of 5%. The results demonstrated that all pastes provided diffusion of hydroxyl ions through the dentinal tubules. The combination of Aloe vera and CH (group CH/A) provided a constant release of calcium ions. Group CH/A/P showed the highest pH at 24 and 72 h. In conclusion, the experimental pastes containing Aloe vera were able to enable the diffusion of hydroxyl ions through the dentinal tubules.

Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome.

Science.gov (United States)

Bush, J; van den Boom, R; Franklin, S

2018-01-01

Anecdotally, aloe vera is used to treat gastric ulceration, although no studies have yet investigated its efficacy in horses. To test the hypothesis that aloe vera would be noninferior to omeprazole in the treatment of equine gastric ulcer syndrome. Randomised, blinded clinical trial. Forty horses with grade ≥2 lesions of the squamous and/or glandular mucosa were randomly assigned to one of two groups. Horses received either aloe vera inner leaf gel (17.6 mg/kg bwt) b.i.d. or omeprazole (4 mg/kg bwt) s.i.d. for approximately 28 days, after which a repeat gastroscopic examination was performed to determine disease resolution. Horses with persistent lesions were offered a further 28 days of treatment with omeprazole (4 mg/kg bwt s.i.d.) and were re-examined on completion of treatment. Efficacy analyses were based on 39 horses that completed the trial. Equine squamous gastric disease (ESGD) was observed in 38 horses; improvement and healing rates in these horses were 56% and 17%, respectively, in the aloe vera group, and 85% and 75%, respectively, in the omeprazole group. Healing was less likely to occur in horses with prolonged gastric emptying. Equine glandular gastric disease (EGGD) was less common than ESGD (n = 14) and numbers were too small to perform meaningful statistical analyses. The hypothesis that aloe vera would be noninferior to omeprazole was not supported. No placebo control group was included. Limited numbers preclude any comment on the efficacy of aloe vera in the treatment of EGGD. Treatment with aloe vera was inferior to treatment with omeprazole. © 2017 EVJ Ltd.

Acemannan and Fructans from Aloe vera (Aloe barbadensis Miller) Plants as Novel Prebiotics.

Science.gov (United States)

Quezada, Maria Paz; Salinas, Carlos; Gotteland, Martin; Cardemil, Liliana

2017-11-22

The nutraceutical properties of Aloe vera have been attributed to a glucomannan known as acemannan. Recently information has been published about the presence of fructans in Aloe vera but there are no publications about acemannan and fructans as prebiotic compounds. This study investigated in vitro the prebiotic properties of these polysaccharides. Our results demonstrated that fructans from Aloe vera induced bacterial growth better than inulin (commercial FOS). Acemannan stimulated bacterial growth less than fructans, and as much as commercial FOS. Using qPCR to study the bacterial population of human feces fermented in a bioreactor simulating colon conditions, we found that fructans induce an increase in the population of Bifidobacterium spp. Fructans produced greater amounts of short chain fatty acids (SCFA), while the branched-chain fatty acids (BCFA) did not increase with these polysaccharides. Acemannan increased significantly acetate concentrations. Therefore, both Aloe vera polysaccharides have prebiotic potentials.

The effect of Aloe vera gel on viability of dental pulp stem cells.

Science.gov (United States)

Sholehvar, Fatemeh; Mehrabani, Davood; Yaghmaei, Parichehr; Vahdati, Akbar

2016-10-01

Dental pulp stem cells (DPSCs) can play a prominent role in tissue regeneration. Aloe vera L. (Liliaceae) contains the polysaccharide of acemannan that was shown to be a trigger factor for cell proliferation, differentiation, mineralization, and dentin formation. This study sought to determine the viability of DPSCs in Aloe vera in comparison with Hank's balanced salt solution (HBSS). Twelve rabbits underwent anesthesia, and their incisor teeth were extracted; the pulp tissue was removed, chopped, treated with collagenase and plated in culture flasks. DPSCs from passage 3 were cultured in 24-well plates, and after 3 days, the culture media changed to 10, 25, 50, and 100% concentrations of Aloe vera at intervals of 45 and 90 min and 3 and 6 h. Distilled water was used as negative and HBSS as positive control for comparison. The cell morphology, viability, population doubling time (PDT), and growth kinetics were evaluated. RT-PCR was carried out for characterization and karyotyping for chromosomal stability. Aloe vera showed a significant higher viability than HBSS (74.74%). The 50% Aloe vera showed higher viability (97.73%) than other concentrations. PDT in 50% concentration was 35.1 h and for HBSS was 49.5 h. DPSCs were spindle shaped and were positive for CD73 and negative for CD34 and CD45. Karyotyping was normal. Aloe vera as an inexpensive and available herb can improve survival of avulsed or broken teeth in emergency cases as a transfer media. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Meristem Culture of Aloe vera L

International Nuclear Information System (INIS)

Kay Thi Mya; Thida Myint; Myo Han; Khin Maung Sein

2005-10-01

Shoot tips of Aloe vera L were excised and inoculated in basal and modified MS (Murashige and Skoog, 1962) medium. Growth regulators and growth factors were supplemented to the basal medium. Development of explants, initiation of callus and multiplication of shoots in culture were recorded.

Oligosaccharides isolated from Agave vera cruz

NARCIS (Netherlands)

Vliegenthart, J.F.G.; Dorland, L.; Kamerling, J.P.; Satyanarayana, M.N.

1977-01-01

The structures of naturally occurring and enzymically synthesized oligosaccharides, consisting of fructose and glucose residues and having d.p. 3–8, in the stem of Agave vera cruz have been investigated by using methylation analysis, mass spectrometry, and p.m.r. spectroscopy. The naturally

Bacterial leaf rot of Aloe vera L., caused byErwinia chrysanthemi biovar 3

NARCIS (Netherlands)

Laat, de P.C.A.; Verhoeven, J.T.W.; Danse, J.D.

1994-01-01

A severe attack of the bacteriumErwinia chrysantemi biovar 3 on the succulentAloe vera on the Carribean island of Aruba is described. Biochemical and pathological characteristics of strains are presented, including results of successful inoculation experiments onAloe vera. This is the first report

Penggunaan Gel Lidah Buaya (Aloe Vera) sebagai Koagulan Alami dalam Penjernihan Air Sumur di Desa Sausu Tambu Kecamatan Sausu

OpenAIRE

Mujariah, Mujariah; Abram, Paulus Hengky; Jura, Minarni Rama

2016-01-01

Research on the use of aloe vera gel (aloe vera) as a natural coagulant in water purification village wells Sausu Tambu has been done. This study aims to determine whether aloe vera gel can be used as a natural coagulant and determine the optimum ratio of aloe vera gel in water (V/V) which is used in the purification of water wells in the village Sausu Tambu. Research was conducted on the water sample preparation, natural production of aloe vera gel, water treatment and analysis of water qual...

Ethanolic extract of Aloe vera ameliorates sciatic nerve ligation induced neuropathic pain

Directory of Open Access Journals (Sweden)

Swetha Kanyadhara

2014-01-01

Conclusion: The results of the present study validate the use of EEAV to treat neuropathic pain. This effect may be attributed to the decreased migration of neutrophils and due to the anti-oxidant properties of A. vera. Further studies to confirm the mechanism of action will help develop suitable A. vera formulations for neuropathic pain therapy .

Administration of dried Aloe vera gel powder reduced body fat mass in diet-induced obesity (DIO) rats.

Science.gov (United States)

Misawa, Eriko; Tanaka, Miyuki; Nabeshima, Kazumi; Nomaguchi, Kouji; Yamada, Muneo; Toida, Tomohiro; Iwatsuki, Keiji

2012-01-01

The aim of the present study was to investigate the anti-obesity effects of Aloe vera gel administration in male Sprague-Dawley (SD) rats with diet-induced obesity (DIO). SD rats at 7 wk of age were fed either a standard diet (10 kcal% fat) (StdD) or high-fat (60 kcal% fat) diet (HFD) during the experimental period. Four weeks after of HFD-feeding, DIO rats (11 wk of age) were orally administered with two doses of Aloe vera gel powder (20 and 200 mg/kg/d) for 90 d. Body weights (g) and body fat (%) of HFD fed rats were significantly higher than those of StdD-fed rats. Although a modest decrease of body weight (g) was observed with the administration of dried Aloe vera gel powder, both subcutaneous and visceral fat weight (g) and body fat (%) were reduced significantly in Aloe vera gel-treated rats. Serum lipid parameters elevated by HFD were also improved by the Aloe vera gel treatment. The oxygen consumption (VO(2)), an index of energy expenditure, was decreased in HFD-fed rats compared with that in StdD-fed rats. Administration of Aloe vera gel reversed the change in VO(2) in the HFD-fed rats. These results suggest that intake of Aloe vera gel reduced body fat accumulation, in part, by stimulation of energy expenditure. Aloe vera gel might be beneficial for the prevention and improvement of diet-induced obesity.

Aloe vera in active and passive regions of electronic devices towards a sustainable development

Science.gov (United States)

Lim, Zhe Xi; Sreenivasan, Sasidharan; Wong, Yew Hoong; Cheong, Kuan Yew

2017-07-01

The increasing awareness towards sustainable development of electronics has driven the search for natural bio-organic materials in place of conventional electronic materials. The concept of using natural bio-organic materials in electronics provides not only an effective solution to address global electronic waste crisis, but also a compelling template for sustainable electronics manufacturing. This paper attempts to provide an overview of using Aloe vera gel as a natural bio-organic material for various electronic applications. Important concepts such as responses of living Aloe vera plant towards electrical stimuli and demonstrations of Aloe vera films as passive and active regions of electronic devices are highlighted in chronological order. The biodegradability and biocompatibility of Aloe vera can bring the world a step closer towards the ultimate goal of sustainable development of electronic devices from "all-natural" materials.

Modulatory Role of Aloe vera on Gamma Irradiation Induced Histological Changes in Different Tissues of Rats

International Nuclear Information System (INIS)

Rezk, R.G.

2005-01-01

Aloe Vera is known for its wide medicinal properties. This study was performed to evaluate the role of Aloe vera (Aloe barbadensis Miller) in the amelioration of the histological disorders that occurr in different tissues of albino rats exposed to 7 Gy whole body gamma irradiation, delivered as a single dose. Aloe vera (leaf juice filtrate) was supplemented daily to rats (0.25 ml/kg b wt/day) by gavage, 5 days before irradiation and 10 days after irradiation. Experimental investigations performed 7 and 10 days after exposure to radiation showed that Aloe vera treatment has significantly improved the radiation-induced inflammation, haemorrhage, widening and dilated blood vessela, necrosis, atrophy sloughing in liver, spleen and small intestine (jejenum) tissues of irradiated rats. It is concluded that the synergistic relationship between the elements found in the leaf of Aloe vera could be a useful adjunct for maintaining the integrity of histological architecture

Effects of the application of Aloe vera (L. and microcurrent on the healing of wounds surgically induced in Wistar rats Efeitos da aplicação de Aloe vera (L. e microcorrente no reparo de lesões cirúrgicas induzidas em ratos Wistar

Directory of Open Access Journals (Sweden)

Cristina Cruz Franchini

2009-04-01

Full Text Available PURPOSE: To investigate the effects of topical application of an Aloe vera gel combined or not with microcurrent application on the healing of skin wounds surgically induced in Wistar rats. METHODS: The animals were randomly divided into the following groups: control group, animals topically treated with Aloe vera, animals treated with a microcurrent, and animals receiving topical application of Aloe vera combined with microcurrent application. RESULTS: The results indicated differences in wound healing between the various treatments when compared to the control group. Tissue hyperplasia was lower in the control group compared to the other treated groups. Accelerated wound healing was observed in the group treated with Aloe vera compared to control. Animals submitted to microcurrent application only and the group treated with microcurrent plus Aloe vera presented an earlier onset of the proliferative phase compared to the control group and animals treated with Aloe vera gel alone. Morphometric data confirmed the structural findings. CONCLUSION: Simultaneous application of Aloe vera gel and microcurrent is an excellent choice for the treatment of open wounds thus indicating a synergistic action of these two applications.OBJETIVO: Investigar os efeitos da aplicação tópica do gel de Aloe vera, combinada ou não com a aplicação de microcorrente no reparo de lesões cutâneas induzidas cirurgicamente em ratos Wistar. MÉTODOS: Os animais foram distribuídos aleatoriamente em: grupo controle, tratado topicamente com gel in natura de Aloe vera, tratado com microcorrente e tratado com aplicação tópica de Aloe vera associada à microcorrente. RESULTADOS: Os resultados do presente trabalho indicaram que o reparo tecidual ocorreu de forma diferenciada nos vários tratamentos empregados quando comparados ao grupo controle. A hiperplasia tecidual no grupo controle foi menor que a observada nos demais grupos tratados. No grupo tratado com aplica

Aloe vera attenuated gastric injury on indomethacin-induced gastropathy in rats.

Science.gov (United States)

Werawatganon, Duangporn; Rakananurak, Narisorn; Sallapant, Sasipim; Prueksapanich, Piyapan; Somanawat, Kanjana; Klaikeaw, Naruemon; Rerknimitr, Rungsun

2014-12-28

To evaluate the protective effects of Aloe vera on gastric injury in rats with indomethacin (IMN)-induced gastropathy. Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control, n = 6) was given distilled water (DW) orally. Group 2 (IMN, n = 6) was given oral IMN (150 mg/kg) dissolved in 5% sodium bicarbonate (NaHCO3 (-)) at time 0 and 4 h. Group 3 (Aloe vera-treated, n = 6) was given oral Aloe vera (150 mg/kg) dissolved in DW and IMN at time 0 and 4 h. Eight hours later, the stomach was removed to determine gastric malondialdehyde (MDA), the number of interleukin (IL)-18 positive stained cells (%) by immunohistochemistry, and for histopathological examination. Then, the serum was collected to determine tumor necrosis factor (TNF)-α and cytokine-induced neutrophil chemoattractant (CINC)-1 by sandwich enzyme linked immunosorbent assay method. In the IMN group, serum TNF-α, CINC-1 and gastric MDA were significantly increased when compared to the control group (27.78 ± 1.52 pg/mL vs 85.07 ± 49.11 pg/mL, P = 0.009; 104.55 ± 45.80 pg/mL vs 1054.70 ± 20.38 pg/mL, and 1.74 ± 0.21 nmol/mg vs 9.36 ± 1.07 nmol/mg protein, P = 0.000, respectively). The mean level of TNF-α, CINC-1 and gastric MDA in the Aloe vera-treated group were improved as compared with the IMN group (85.07 ± 49.11 pg/mL vs 35.19 ± 1.61 pg/mL, P = 0.021; 1054.70 ± 20.38 pg/mL vs 813.56 ± 239.04 pg/mL, P = 0.025; and 9.36 ± 1.07 nmol/mg vs 2.67 ± 0.64 nmol/mg protein, P = 0.000, respectively). The number of IL-18 positive stained cells (%) in the gastric epithelial cells of the IMN group was significantly higher than the control group (5.01% ± 3.73% vs 30.67% ± 2.03%, P = 0.000, respectively). In contrast, Aloe vera treatment decreased the number of IL-18 positive stained cells (%) significantly when compared with the IMN group (30.67% ± 2.03% vs 13.21% ± 1.10%, P = 0.000, respectively). Most rats in the IMN group developed moderate to severe gastric inflammation

The Anti-Nociceptive Effect of Aloe. Vera Aqueous Extract in Fructose-Fed Male Rats

Directory of Open Access Journals (Sweden)

Mohammad Reza Shahraki

2010-05-01

Full Text Available A B S T R A C T Introduction: Aloe Vera extract is used as an anti-inflammatory and anti-bradikinin agent in laboratory animals. The aim of this survey was to evaluate the ant-nociceptive effect of A. Vera aqueous extract in fructose-fed male rats. Methods: Forty-five Wistar-Albino male rats were equally and randomly divided into five groups including sham operated and four test groups. Sham operated group consumed tap water and the test groups consumed fructoseenriched water. Test groups 2, 3 and 4 additionally received, 0, 100, 150 and 200 mg/kg of A. Vera extract, respectively, whereas the other test group received distilled water daily. Tail flick reaction time, serum glucose and oral glucose tolerance test (OGTT were measured. The results were analyzed by SPSS software using ANOVA and Tukey tests. Results were expressed as mean ± SD. Statistical differences were considered significant at p<0.05. Results: The results showed that tail flick reaction time significantly increased in test group 3 which received 200 mg/kg A. Vera extract comparing with that of sham operated group. However, OGTT and serum glucose value were significantly increased in all fructose-fed male rats comparing with those of sham operated group. Discussion: These results indicated that A. Vera aqueous extract can affect tail flick reaction time in fructose-fed male rats. Further studies are required to show the exact mechanism of anti-nociceptive effect of A. Vera extract.

Strong enhancement of antioxidant activity of Aloe vera extracts by gamma irradiation

Energy Technology Data Exchange (ETDEWEB)

Lee, Eun Mi; Bai, Hyoung Woo; Lee, Seung Sik; Hong, Sung Hyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Cho, Jae Young; Chung, Byung Yeoup [Chonbuk National University, Jeonju (Korea, Republic of)

2011-10-15

The World Health Organization (WHO) has estimated that approximately 80% of individuals rely on traditional medicines. Among over 400 Aloe species, Aloe vera was the most accepted species for various medical, cosmetic and neutraceutical purposes. Aloe vera (syn.: Aloe barbadensis Miller) was a perennial succulent plant belonging to the Aloeaceae family (subfamily of the Asphodelaceae). It has been reported that Aloe vera extracts were useful in the treatment of wound and burn healing, minor skin infections, sebaceous cyst, diabetes, and elevated blood lipids in humans. Recent studies have shown that treatment with either Aloe vera crude gel or its extracts, such as acemannan, {beta}-sitosterol, and others, resulted in faster healing of wounds by stimulating fibroblast proliferation, collagen deposition, angiogenesis, and production of growth factors. Ionizing radiation technology has been developed to improve our daily life such as cancer therapy and sterilizing tool due to its unique feature that could be penetrated biomaterials leading to alter their own physical properties. More recently, many studies have attempted to apply the radiation technology to enhance their biological activities. At present, however, very little was known about whether naturally-occurring phenolic compounds of ethanolic aloe gel extracts that were altered their biological activities by ionizing radiation to serve as antioxidant in the body to reduce ROS produced by the stresses. The purpose of the current study was to investigate the influence of gamma irradiation on antioxidant activity of Aloe vera extracts, and open insight new possibilities that gamma ray could be a powerful tool for improving its own biological activities

Modulation of radiation injuries in rats receiving multiple doses of Aloe Vera

International Nuclear Information System (INIS)

Azab, Kh.SH.

2007-01-01

This study has been performed to examine the efficacy of Aloe vera juice (Aloe barbadensis Miller) against radiation injuries of 7 Gy whole body gamma irradiation (single dose). Inductions of lipid peroxidation (thiobarbituric acid reactive substances, (TBARS)) of biomembranes lipids as well as the subsequent changes in the activities of subcellular organelle marker enzymes were discussed. Activities of glutamate dehydrogenase (GDH), acid phosphatase and glucose-6-phosphatase (marker enzymes of mitochondria, lysosome and microsomes, respectively) were estimated. The activities of these enzymes were also measured in cytosol. Subcellular fractionation's were performed in liver, heart and spleen tissues. Aloe vera was supplemented daily to rats (0.25 ml/kg body wt/day) by gavage, 5 days before irradiation and treatment was extended for 10 days post irradiation. Experimental investigations were performed on the 3 rd and 10 th day after exposure to radiation. The results obtained indicated that, Aloe vera administration has significantly minimized the radiation-induced increase in the amount of TBARS in different cell fractions as compared with control rats. Significant amelioration in the activities of organelles marker enzymes GDH, acid phosphatase and glucose-6-phosphatase was observed from 3 rd up to 10 th days for the 3 tissues. The results also detected improvement in cytosolic enzyme activities due to Aloe vera intake. It could be suggested that the diverse active constituents of Aloe vera play a significant role in decreasing the peroxidation of subcellular membrane lipids induced by radiation exposure, prevent diffusion of organelle enzymes to cytosol and consequently salvage the integrity of living cell

Strong enhancement of antioxidant activity of Aloe vera extracts by gamma irradiation

International Nuclear Information System (INIS)

Lee, Eun Mi; Bai, Hyoung Woo; Lee, Seung Sik; Hong, Sung Hyun; Cho, Jae Young; Chung, Byung Yeoup

2011-01-01

The World Health Organization (WHO) has estimated that approximately 80% of individuals rely on traditional medicines. Among over 400 Aloe species, Aloe vera was the most accepted species for various medical, cosmetic and neutraceutical purposes. Aloe vera (syn.: Aloe barbadensis Miller) was a perennial succulent plant belonging to the Aloeaceae family (subfamily of the Asphodelaceae). It has been reported that Aloe vera extracts were useful in the treatment of wound and burn healing, minor skin infections, sebaceous cyst, diabetes, and elevated blood lipids in humans. Recent studies have shown that treatment with either Aloe vera crude gel or its extracts, such as acemannan, β-sitosterol, and others, resulted in faster healing of wounds by stimulating fibroblast proliferation, collagen deposition, angiogenesis, and production of growth factors. Ionizing radiation technology has been developed to improve our daily life such as cancer therapy and sterilizing tool due to its unique feature that could be penetrated biomaterials leading to alter their own physical properties. More recently, many studies have attempted to apply the radiation technology to enhance their biological activities. At present, however, very little was known about whether naturally-occurring phenolic compounds of ethanolic aloe gel extracts that were altered their biological activities by ionizing radiation to serve as antioxidant in the body to reduce ROS produced by the stresses. The purpose of the current study was to investigate the influence of gamma irradiation on antioxidant activity of Aloe vera extracts, and open insight new possibilities that gamma ray could be a powerful tool for improving its own biological activities

In vitro activity of Aloe vera inner gel against microorganisms grown in planktonic and sessile phases.

Science.gov (United States)

Cataldi, V; Di Bartolomeo, S; Di Campli, E; Nostro, A; Cellini, L; Di Giulio, M

2015-12-01

The failure of traditional antimicrobial treatments is becoming a worldwide problem. The use of Aloe vera is of particular interest for its role as curative agent and its efficacy in complementary therapies for a variety of illnesses. This study evaluated the antimicrobial activity of A. vera inner gel against a panel of microorganisms, Gram-positive and -negative bacteria, and Candida albicans. In addition to A. vera inner gel being used in the treatment of peptic ulcers, in dermatological treatments, and wound healing, it was also tested on the sessile phase of clinical Helicobacter pylori strains (including multi-drug-resistant strains) and on planktonic and sessile phase of Staphylococcus aureus/Pseudomonas aeruginosa clinical isolates from venous leg ulcers.A. vera inner gel expresses its prevalent activity against Gram-negative bacteria and C. albicans in respect to Gram-positive bacteria. The results of the A. vera antibiofilm activity showed a decrease of the produced biomass in a concentration-dependent-way, in each analyzed microorganism. The data obtained show that A. vera inner gel has both an antimicrobial and antibiofilm activity suggesting its potential use for the treatment of microbial infections, in particular for H. pylori gastric infection, especially in case of multi-drug-resistance, as well as for an effective wound dressing. © The Author(s) 2015.

In-vitro assessment and pharmacodynamics of nimesulide incorporated Aloe vera transemulgel.

Science.gov (United States)

Vandana, K R; Yalavarthi, Prasanna R; Sundaresan, C R; Sriramaneni, Raghava N; Vadlamudi, Harini C

2014-06-01

The aim of the investigation was to prepare nimesulide emulsion for incorporation in Aloe vera gel base to formulate 'nimesulide - Aloe vera transemulgel' (NAE) and to carryout in-vitro assessment and in-vivo anti-inflammatory studies of the product. Although the use of nimesulide is banned for oral administration, due to its potential for inducing hepatotoxicity and thrombocytopenia, the use of nimesulide for topical delivery is prominent in the treatment of many inflammatory conditions including rheumatoid arthritis. The drug loading capacity of transdermal gels is low for hydrophobic drugs such as nimesulide. Nimesulide can be effectively incorporated into emulgels (a combination of emulsion and gel). Aloe vera has a mild anti-inflammatory effect and in the present study Aloe vera gel was formulated and used as a gel base to prepare NAE. The emulgels thus prepared were evaluated for viscosity, pH, in-vitro permeation, stability and skin irritation test. In-vivo anti-inflammatory studies were performed using carrageenan induced hind paw edema method in Wistar rats. The results were compared with that of commercial nimesulide gel (CNG). From the in-vitro studies, effective permeation of nimesulide from NAE (53.04 %) was observed compared to CNG (44.72 %) at 30 min indicating better drug release from NAE. Topical application of the emulgel found no skin irritation. Stability studies proved the integrity of the formulation. The percentage of inhibition of edema was highest for the prepared NAE (67.4 % inhibition after 240 min) compared to CNG (59.6 %). From our results, it was concluded that the Aloe vera gel acts as an effective gel base to prepare nimesulide emulgel with high drug loading capacity (86.4 % drug content) compared to CNG (70.5 % drug content) with significant anti-inflammatory effect.

Building HVAC control knowledge data schema – Towards a unified representation of control system knowledge

Energy Technology Data Exchange (ETDEWEB)

Chen, Yan; Treado, Stephen J.; Messner, John I.

2016-12-01

Building control systems for Heating, Ventilation, and Air Conditioning (HVAC) play a key role in realizing the functionality and operation of building systems and components. Building Control Knowledge (BCK) is the logic and algorithms embedded throughout building control system. There are different methods to represent the BCK. These methods differ in the selection of BCK representing elements and the format of those elements. There is a lack of standard data schema, for storing, retrieving, and reusing structured BCK. In this study, a modular data schema is created for BCK representation. The data schema contains eleven representing elements, i.e., control module name, operation mode, system schematic, control flow diagram, data point, alarm, parameter, control sequence, function, and programming code. Each element is defined with specific attributes. This data schema is evaluated through a case study demonstration. The demonstration shows a new way to represent the BCK with standard formats.

Effect of salicylic acid and aloe vera gel on postharvest quality of table grapes ( Vitis Vinifera

Directory of Open Access Journals (Sweden)

H. Peyro

2017-06-01

Full Text Available To investigate the effects of salicylic acid dipping and Aloe vera gel coating on shelf life and post harvest quality of table grapes (Vitis vinifera of the cultivar Shahroudi, a factorial experiment was conducted on the basis of randomized complete blocks design with three factors and three replicates in agricultural faculty of Islamic Azad University in 2014. The treatments were dipping in Salicylic acid (three levels of 0, 1 and 2 mmmol-1 for 15 minutes and coating with Aloe vera gel (four levels of 0, 10%, 15% and 20% w/v and measurement of traits in 1st day, 30th day and 60th day after treatment of berries. The results showed that the interaction effect of salicylic acid and Aloe vera gel application was significant on all of traits except for pH value in a way that the best and the minimum weight loss (0.09g was obtained by application of 2 mmol-1 Salicylic acid and 20% Aloe vera gel in 1st day after treatment. The greatest amount of total soluble solids (428.43 g.100g-1 fruit juice was found in 2 mmol-1 Salicylic acid and 15% Aloe vera gel in 60th day. The highest Catalase enzyme activity (0.0013 Ua.mg-1Pro was attained in 2 mmol-1 Salicylic acid and 15% Aloe vera gel in 30th day. These results demonstrated that treatment of grape berries by salicylic acid and Aloe vera gel had positive effect on shelf life of table grapes and their postharvest quality

Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice.

Science.gov (United States)

Saini, M; Goyal, Pradeep Kumar; Chaudhary, Geeta

2010-01-01

Human populations are increasingly exposed to various carcinogens such as chemicals, radiation, and viruses in the environment. Chemopreventive drugs of plant origin are a promising strategy for cancer control because they are generally nontoxic or less toxic than synthetic che-mopreventive agents, and can be effective at different stages of carcinogenesis. The present investigation was undertaken to explore the antitumor activity of topical treatment with aloe vera (Aloe vera) gel, oral treatment with aloe vera extract, and topical and oral treatment with both gel and extract in stage-2 skin carcinogenesis in Swiss albino mice induced by 7,12-dim ethylbenz(a)anthracene (DMBA) and promoted croton (Croton tiglium) oil. The animals were randomly divided into 4 groups and treated as follows: Group I, DMBA + croton oil only (controls); Group II, DMBA + croton oil + topical aloe vera gel; Group III, DMBA + croton oil + oral aloe vera extract; Group I V, DMBA + croton oil + topical aloe vera gel + oral aloe vera extract. Results showed that body weight was significantly increased from 78.6% in the control group (Group I) to 92.5%, 87.5%, and 90.0% in Groups II, III, and I V, respectively. A 100% incidence of tumor development was noted in Group I, which was decreased to 50%, 60%, and 40% in Groups II, III, and I V, respectively. Also in Groups II, III, and IV, the cumulative number of papillomas was reduced significantly from 36 to 12, 15, and 11; tumor yield from 3.6 to 1.2, 1.5, and 1.1; and tumor burden from 3.6 to 2.4, 2.50, and 2.75, respectively, after treatment with aloe vera. Conversely, the average latent period increased significantly from 4.9 (Group I) to 5.23, 5.0, and 6.01 weeks in Groups II, III, and I V, respectively. We conclude that aloe vera protects mice against DMBA/croton oil-induced skin papillomagenesis, likely due to the chemopreventive activity of high concentrations of antioxidants such as vitamins A, C, and E; glutathione peroxidase; several

Effects of Aloe vera on dressing percentage and haemato-biochemidal parameters of broiler chickens

Directory of Open Access Journals (Sweden)

Jagmohan Singh

2013-09-01

Full Text Available Aim: To evaluate the effects of Aloe vera on dressing percentage and hemato-biochemical parameters of broiler chickens.Materials and Methods: A total of 90 chicks were used in this study. They were randomly allocated into 3 treatment groups.Fresh Aloe vera leaf juice (ALJ was prepared and administered to the test group T3 at the rate of 20 g/Lin drinking water daily.This study was carried out for 42 days. Dressing percentage and hemato-biochemical parameters were recorded at the end ofexperiment.Results: Group that was given Aloe vera (T3 showed numerically higher dressing percentage as compared to control group(T1 and drug control group (T2. It also showed significantly (P0.05 differences were observed in other parameters among all the treatment groups.Conclusion: Aloe vera has potential to be a growth promoter in broiler chicks and its growth promoting effects are comparableto that of antibiotic growth promoter (AGP.

Encapsulation of Aloe Vera and Its Effect During Yogur Incubation

Directory of Open Access Journals (Sweden)

Ricardo Adolfo Parra Huertas

2014-11-01

Full Text Available The yogurt is milk derivative highly consumed around the world,as well as aloe vera. Both have reports tocontribute to human health. The purpose of this research is to determine the effect of the addition of capsules with aloe vera during the incubation of yogurt. Aloeverawas encapsulated in alginate at two different concentrations, 1% and 2%,addingthe capsules from the moment of incubation and comparing the effect of the addition of capsules withthe non-addition of them. For these samples were determined: pH, acidity, syneresis, lactic acid bacteria count, sensory evaluation and proximate analysis. The results indicated that for the three treatments pH values and acid behaved similarly to each characteristic of the yogurt during incubation. The lactic acid bacteria count indicated that treatment with capsules containing 2% sodium alginate had higher counts. Sensorially, three treatments had a favorable acceptability; proximate analysis had favorable values . In conclusion,the tests showed the viability of encapsulated aloe vera in the manufacture of yogurt during incubation time without being affected by the concentration of sodium alginate.

Growth Period Effects on the Protective Properties of Aloe vera Against t-BHP-Induced Oxidative Stress in Chang Cells.

Science.gov (United States)

Hwang, Jin-Woo; Kim, Eun-Kyung; Kim, Yon-Suk; Lee, Jae Woong; Lee, Jeong-Jun; Pyo, Han-Jong; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam

2015-12-28

Aloe vera has been used in traditional medicine for the therapy of a variety of disorders, such as wounds and burns. However, few studies have examined the antioxidant capacities of A. vera plants during different growth periods. In order to investigate the effects of growth on antioxidant activity, A. vera was prepared from 2-, 4-, 6-, 8-, and 12-month-old aloe. The extracts from 6-month-old A. vera showed the highest contents of flavonoids (9.750 mg catechin equivalent/g extract) and polyphenols (23.375 mg gallic acid equivalent/g extract) and the highest ferric reducing antioxidant power (0.047 mM ferrous sulfate equivalent/mg extract). The extract from 6-month-old A. vera exhibited the highest free radical scavenging potential, and the lowest IC50 values were found for 2,2-diphenyl-1-picrylhydrazyl (0.26 mg/ml) and alkyl radicals (0.50 mg/ml). In addition, the extract from 6-month-old A. vera showed the greatest effects on cell viability in normal liver cells. Based on these findings, the extract from 6-month-old A. vera was examined further in order to determine its protective potential against tert-butyl hydroperoxide (t-BHP)-induced oxidative stress. The extract from 6-monthold A. vera at a concentration of 0.25 mg/ml showed the highest protective activity against t-BHP-induced reactive oxygen species production. These findings suggested that harvesting regimens were critical in the regulation of effects of the bioactive potential of A. vera on antioxidant activity.

Release Behavior and Antibacterial Activity of Chitosan/Alginate Blends with Aloe vera and Silver Nanoparticles.

Science.gov (United States)

Gómez Chabala, Luisa Fernanda; Cuartas, Claudia Elena Echeverri; López, Martha Elena Londoño

2017-10-24

Aloe vera is a perennial plant employed for medical, pharmaceutical and cosmetic purposes that is rich in amino acids, enzymes, vitamins and polysaccharides, which are responsible for its therapeutic properties. Incorporating these properties into a biopolymer film obtained from alginate and chitosan allowed the development of a novel wound dressing with antibacterial capacity and healing effects to integrate the antibacterial capacity of silver nanoparticles with the healing and emollient properties of Aloe vera gel. Three alginate-chitosan matrices were obtained through blending methods using different proportions of alginate, chitosan, the Aloe vera (AV) gel and silver nanoparticles (AgNps), which were incorporated into the polymeric system through immersion methods. Physical, chemical and antibacterial characteristics were evaluated in each matrix. Interaction between alginate and chitosan was identified using the Fourier transform infrared spectroscopy technique (FTIR), porosity was studied using scanning electron microscopy (SEM), swelling degree was calculated by difference in weight, Aloe vera gel release capacity was estimated by applying a drug model (Peppas) and finally antibacterial capacity was evaluated against S. Aureus and P. aeruginosa . Results show that alginate-chitosan (A (1:3 Chit 1/Alg 1); B (1:3 Chit 1.5/Alg 1) and C (3:1 Chit 1/Alg 1/B12)) matrices with Aloe vera (AV) gel and silver nanoparticles (AgNps) described here displayed antibacterial properties and absorption and Aloe vera release capacity making it a potential wound dressing for minor injuries.

The combined effects of Aloe vera gel and silver nanoparticles on wound healing in rats

Directory of Open Access Journals (Sweden)

Y. Yousefpoor

2016-01-01

Full Text Available Objective(s: This study was aimed at investigating the synergy effects of Aloe vera gel and silver nanoparticles on the healing rate of the cutting wounds. Materials and Methods: In order to determine the concentration of silver nanoparticles in Aloe vera gel, the MBC methods were applied on the most common bacteria infecting wounds, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa. The cutting wounds with Full-thickness skin were dorsally created on rats; then the rats were divided into 4 groups. The treatments groups included: mixture of Aloe vera gel and silver nanoparticles, Aloe vera gel alone and silver nanoparticles alone in addition to control groups. The treatment was carried out for 2 weeks and the size of the wound closures were measured by an image software analysis. Results:There was no significant difference (p

Systemic mastocytosis in a patient with polycythemia vera treated with radioactive phosphorus

International Nuclear Information System (INIS)

Eagan, J.W. Jr.; Baughman, K.L.; Miller, S.; Conley, C.L.; Eggleston, J.C.

1977-01-01

Systemic mastocytosis occurred as a fatal event in a patient with long-standing polycythemia vera. The patient had been treated over the course of 21 yr with radioactive phosphorus. Possible relationships between mastocytosis and polycythemia vera, and also between mastocytosis and treatment with ionizing radiation, are discussed. Histopathologic and electron microscopic findings are illustrated. Difficulties in establishing the diagnosis of mast cell disease in this setting are also described

Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera

Directory of Open Access Journals (Sweden)

Shuhei Ito

2017-01-01

Full Text Available Extramedullary hematopoiesis (EMH occasionally occurs in patients exhibiting hematological disorders with decreased hematopoietic efficacy. EMH is rarely observed in the spinal epidural space and patients are usually asymptomatic. In particular, in the patients with polycythemia vera, spinal cord compression due to EMH is extremely rare. We report a case of polycythemia vera, in which operative therapy proved to be an effective treatment for myelopathy caused by spinal EMH.

Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera.

Science.gov (United States)

Ito, Shuhei; Fujita, Nobuyuki; Hosogane, Naobumi; Nagoshi, Narihito; Yagi, Mitsuru; Iwanami, Akio; Watanabe, Kota; Tsuji, Takashi; Nakamura, Masaya; Matsumoto, Morio; Ishii, Ken

2017-01-01

Extramedullary hematopoiesis (EMH) occasionally occurs in patients exhibiting hematological disorders with decreased hematopoietic efficacy. EMH is rarely observed in the spinal epidural space and patients are usually asymptomatic. In particular, in the patients with polycythemia vera, spinal cord compression due to EMH is extremely rare. We report a case of polycythemia vera, in which operative therapy proved to be an effective treatment for myelopathy caused by spinal EMH.

Myelopathy due to Spinal Extramedullary Hematopoiesis in a Patient with Polycythemia Vera

OpenAIRE

Ito, Shuhei; Fujita, Nobuyuki; Hosogane, Naobumi; Nagoshi, Narihito; Yagi, Mitsuru; Iwanami, Akio; Watanabe, Kota; Tsuji, Takashi; Nakamura, Masaya; Matsumoto, Morio; Ishii, Ken

2017-01-01

Extramedullary hematopoiesis (EMH) occasionally occurs in patients exhibiting hematological disorders with decreased hematopoietic efficacy. EMH is rarely observed in the spinal epidural space and patients are usually asymptomatic. In particular, in the patients with polycythemia vera, spinal cord compression due to EMH is extremely rare. We report a case of polycythemia vera, in which operative therapy proved to be an effective treatment for myelopathy caused by spinal EMH.

Aloe vera bathing improved physical and humoral protection in breeding stock after induced spawning in matrinxã (Brycon amazonicus).

Science.gov (United States)

Zanuzzo, Fábio S; Zaiden, Sérgio F; Senhorini, José A; Marzocchi-Machado, Cleni M; Urbinati, Elisabeth C

2015-07-01

In this study, we show that induced spawning causes stress, an intense loss of epithelia and immunosuppression, decreasing physical and humoral protection in fish, effects that were prevented or improved in fish bathed with Aloe vera. A. vera has several medicinal properties, including wound healing and immunostimulatory effects, which we observed in this study. Fish bathed with A. vera had a higher number of epidermal goblet cells and, in general, an improved wound healing rate compared with the control after induced spawning. These effects might be related to (1) the stimulation of leukocyte activity, represented here by the increased leukocyte respiratory activity triggered by A. vera (leukocytes are recognized as playing an important role in wound repair); (2) the antimicrobial properties of A. vera, which decrease wound infection and accelerate the healing process; and (3) several mechanisms that explain the healing effect of A. vera (increased collagen synthesis, rate of epithelialization, and anti-inflammatory and moisturizing effects). Our results also suggest that caution is necessary during the induced spawning process, especially during stripping, and A. vera bathing is recommended after intensive aquaculture operations. Copyright © 2015 Elsevier Ltd. All rights reserved.

UJI AKTIVITAS KOMBINASI EKSTRAK AIR LIDAH BUAYA ( Aloe vera L.) DAN AKAR MANIS (Glycyrrhiza glabra L.) SEBAGAI PENYUBUR RAMBUT

OpenAIRE

Sulistiorini Indriaty; Teti Indrawati; Shelly Taurhesia

2016-01-01

Aloe vera (Aloe vera L.) contains amino acids, vitamins, folic acid, and liquorice (Glycyrrhiza glabra L) containing glisirizin, and flavonoids, which have properties as fertilizer hair. This study aims to obtain a combination of extracts with activity most optimal fertilizer hair, made 3 combination with a combination of 1 (the water extract of liquorice concentration of 2.5% and 7.5% aloe vera), a combination of 2 (the water extract of liquorice concentrations of 2, 5% and 2.5% aloe vera), ...

Aloe vera gel improves behavioral deficits and oxidative status in streptozotocin-induced diabetic rats.

Science.gov (United States)

Tabatabaei, Seyed Reza Fatemi; Ghaderi, Shahab; Bahrami-Tapehebur, Mohammad; Farbood, Yaghoob; Rashno, Masome

2017-12-01

Oxidative stress has a major role in progression of diabetes-related behavioral deficits. It has been suggested that Aloe vera has anti-diabetic, antioxidative, and neuroprotective effects. The present study was designed to determine the effects of Aloe vera gel on behavioral functions, oxidative status, and neuronal viability in the hippocampus of streptozotocin (STZ)-induced diabetic rats. Fifty five adult male Wistar rats were randomly divided into five groups, including: control (normal saline 8ml/kg/day; P.O.), diabetic (normal saline 8ml/kg/day; P.O.), Aloe vera gel (100mg/kg/day; P.O.), diabetic+Aloe vera gel (100mg/kg/day; P.O.) and diabetic+NPH insulin (10 IU/kg/day; S.C.). All treatments were started immediately following confirmation of diabetes in diabetic groups and were continued for eight weeks. Behavioral functions were evaluated by employing standard behavioral paradigms. Additionally, oxidative status and neuronal viability were assessed in the hippocampus. The results of behavioral tests showed that diabetes enhanced anxiety/depression-like behaviors, reduced exploratory and locomotor activities, decreased memory performance, and increased stress related behaviors. These changes in diabetic rats were accompanied by increasing oxidative stress and neuronal loss in the hippocampus. Interestingly, eight weeks of treatment with Aloe vera gel not only alleviated all the mentioned deficits related to diabetes, but in some aspects, it was even more effective than insulin. In conclusion, the results suggest that both interrelated hypoglycemic and antioxidative properties of Aloe vera gel are possible mechanisms that improve behavioral deficits and protect hippocampal neurons in diabetic animals. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Preliminary antiplaque efficacy of aloe vera mouthwash on 4 day plaque re-growth model: randomized control trial.

Science.gov (United States)

Gupta, Rajendra Kumar; Gupta, Devanand; Bhaskar, Dara John; Yadav, Ankit; Obaid, Khursheed; Mishra, Sumit

2014-04-01

Due to increasing resistance to antibiotics and rising incidence of oral diseases, there is a need for alternative treatment modalities to combat oral diseases. The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it with the bench mark control chlorhexidine and placebo (saline water). A total of 300 systemically healthy subjects were randomly allocated into 3 groups: Aloe vera mouthwash group (n=100), control group (=100)-chlorhexidene group and saline water-Placebo (n=100). To begin with, Gingival index (GI) and plaque index (PI) were recorded. Then, baseline plaque scores were brought to zero by professionally cleaning the teeth with scaling and polishing. After randomization of the participants into three groups they were refrained from regular mechanical oral hygiene measures. Subjects were asked to swish with respective mouthwash (Aloe vera mouthwash, 0.2%chlorhexidine gluconate mouthwash, or normal saline) as per therapeutic dose for 4 days. The results showed that Aloe vera mouthrinse is equally effective in reducing plaque as Chlorhexidine compared to placebo over a period of 4 days. There was a significant reduction on plaque in Aloe vera and chlorhexidine groups and no statistically significant difference was observed among them (p>0.05). Aloe vera mouthwash showed no side effects. The results of the present study indicated that Aloe vera may prove an effective mouthwash due to its ability in reducing dental plaque.

Precipitation of hydroxyapatite on electrospun polycaprolactone/aloe vera/silk fibroin nanofibrous scaffolds for bone tissue engineering.

Science.gov (United States)

Shanmugavel, Suganya; Reddy, Venugopal Jayarama; Ramakrishna, Seeram; Lakshmi, B S; Dev, Vr Giri

2014-07-01

Advances in electrospun nanofibres with bioactive materials have enhanced the scope of fabricating biomimetic scaffolds for tissue engineering. The present research focuses on fabrication of polycaprolactone/aloe vera/silk fibroin nanofibrous scaffolds by electrospinning followed by hydroxyapatite deposition by calcium-phosphate dipping method for bone tissue engineering. Morphology, composition, hydrophilicity and mechanical properties of polycaprolactone/aloe vera/silk fibroin-hydroxyapatite nanofibrous scaffolds along with controls polycaprolactone and polycaprolactone/aloe vera/silk fibroin nanofibrous scaffolds were examined by field emission scanning electron microscopy, Fourier transform infrared spectroscopy, contact angle and tensile tests, respectively. Adipose-derived stem cells cultured on polycaprolactone/aloe vera/silk fibroin-hydroxyapatite nanofibrous scaffolds displayed highest cell proliferation, increased osteogenic markers expression (alkaline phosphatase and osteocalcin), osteogenic differentiation and increased mineralization in comparison with polycaprolactone control. The obtained results indicate that polycaprolactone/aloe vera/silk fibroin-hydroxyapatite nanofibrous scaffolds have appropriate physico-chemical and biological properties to be used as biomimetic scaffolds for bone tissue regeneration. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

File-Based One-Way BISON Coupling Through VERA: User's Manual

Energy Technology Data Exchange (ETDEWEB)

Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-02-28

Activities to incorporate fuel performance capabilities into the Virtual Environment for Reactor Applications (VERA) are receiving increasing attention [1–6]. The multiphysics emphasis is expanding as the neutronics (MPACT) and thermal-hydraulics (CTF) packages are becoming more mature. Capturing the finer details of fuel phenomena (swelling, densification, relocation, gap closure, etc.) is the natural next step in the VERA development process since these phenomena are currently not directly taken into account. While several codes could be used to accomplish this, the BISON fuel performance code [8,9] being developed by the Idaho National Laboratory (INL) is the focus of ongoing work in the Consortium for Advanced Simulation of Light Water Reactors (CASL). Built on INL’s MOOSE framework [10], BISON uses the finite element method for geometric representation and a Jacobian-free Newton-Krylov (JFNK) scheme to solve systems of partial differential equations for various fuel characteristic relationships. There are several modes of operation in BISON, but, this work uses a 2D azimuthally symmetric (R-Z) smeared-pellet model. This manual is intended to cover (1) the procedure pertaining to the standalone BISON one-way coupling from VERA and (2) the procedure to generate BISON fuel temperature tables that VERA can use.

Facile fabrication of aloe vera containing PCL nanofibers for barrier membrane application.

Science.gov (United States)

Carter, Princeton; Rahman, Shekh M; Bhattarai, Narayan

2016-01-01

Guided tissue regeneration (GTR) is a widely used method in dental surgical procedures that utilizes a barrier membrane to exclude migration of epithelium and ensure repopulation of periodontal ligament cells at the sites having insufficient gingiva. Commercial GTR membranes are typically composed of synthetic polymers that have had mild clinical success mostly because of their lack of proper bioactivity and appropriate degradation profile. In this study, a natural polymer, aloe vera was blended with polycaprolactone (PCL) to create nanofibrous GTR membranes by electrospinning. Aloe vera has proven anti-inflammatory properties and enhances the regeneration of periodontium tissues. PCL, a synthetic polymer, is well known to produce miscible polyblends nanofibers with natural polymers. Nanofibrous membranes with varying composition of PCL to aloe vera were fabricated, and several physicochemical and biological properties, such as fiber morphology, wettability, chemical structure, mechanical strength, and cellular compatibility of the membranes were analyzed. PCL/aloe vera membranes with ratios from 100/00 to 70/30 showed good uniformity in fiber morphology and suitable mechanical properties, and retained the integrity of their fibrous structure in aqueous solutions. Experimental results, using cell viability assay and cell attachment observation, showed that the nanofibrous membranes support 3T3 cell viability and could be a potential candidate for GTR therapy.

Aloe vera enhances the innate immune response of pacu (Piaractus mesopotamicus) after transport stress and combined heat killed Aeromonas hydrophila infection.

Science.gov (United States)

Zanuzzo, Fábio S; Sabioni, Rafael E; Montoya, Luz Natalia F; Favero, Gisele; Urbinati, Elisabeth C

2017-06-01

In this study, pacu (Piaractus mesopotamicus) were fed with diets containing Aloe vera for 10 days prior to transport stress and infection with heat killed Aeromonas hydrophila. A. vera is popular around the world due to its medicinal properties, including immunostimulatory effects which was observed in this study. The results show that transport causes immunosuppression, an effect that was prevented by A. vera. Specifically, A. vera prevented reductions of both leukocyte respiratory burst and hemolytic activity of complement system caused by transport. Further, fish fed with A. vera also showed significantly higher leukocyte respiratory burst, serum lysozyme concentrations and activity of complement system 24 h after bacterial infection. Additionally, we observed that A. vera may modulate the innate response through activation of complement system during bacterial immune stimulation. In summary, A. vera extract enhanced innate immune parameters and consequently the ability of fish to cope with pathogens following transport stress. These findings show that A. vera has promise for use in aquaculture and add further evidence that medicinal herbs added to fish feed assist to prevent disease outbreaks. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating gutta percha cones.

Science.gov (United States)

Athiban, Prakash P; Borthakur, Bikash Jyoti; Ganesan, S; Swathika, B

2012-07-01

The aim of this study was to evaluate the antimicrobial efficacy of Aloe vera and to determine its effectiveness in decontaminating gutta percha cones. A concentrated extract of Aloe vera was used to check for the antimicrobial efficacy using the agar well diffusion method. Presence of zones' of diffusion was identified against three common GP contaminants namely, E.coli, E.faecalis and Staph. aureus. New GP Cones, freshly taken out of the packet were then decontaminated for 1minute using Aloe vera gel and then placed in thioglycolate broth to check for the presence of turbidity. The zones of inhibition on the agar plate were measured as 24mm,21mm and 24mm respectively. The broth remained clear even after 48 hours of incubation. We conclude that Aloe vera is indeed effective as a GP decontaminant and it holds a promising future as a medium for storage of GP cones.

The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta-analysis.

Science.gov (United States)

Ali, S; Wahbi, W

2017-10-01

The main objective of oral lichen planus management is to control symptomatic outbreaks via eliminating lesions and alleviating symptoms. Corticosteroids, calcineurin inhibitors, and most of the available modalities are associated with adverse effects, which may limit their use. The aim of this review was to assess the effect of aloe vera on pain alleviation and/or clinical improvement in patients with symptomatic oral lichen planus. MEDLINE-PubMed; CENTRAL, and LILACS were searched in May 2016 to identify all clinical trials evaluating aloe vera vs placebo or corticosteroids for treatment of oral lichen planus. The included studies were five clinical trials and two case reports. From the included studies, there is weak evidence that aloe vera is more efficient than placebo and has comparable effect to triamcinolone acetonide. The meta-analyses show heterogeneity and reveals that aloe vera is inferior to the control in general. Although corticosteroids are still the gold standard, aloe vera shows promising results especially with no adverse effects compared with various adverse effects of corticosteroids. We recommend conducting new randomized clinical trials with larger sample size, sufficiently long follow-up period as well as standardized aloe vera formulations and outcome measures. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Aloe vera attenuated liver injury in mice with acetaminophen-induced hepatitis.

Science.gov (United States)

Werawatganon, Duangporn; Linlawan, Sittikorn; Thanapirom, Kessarin; Somanawat, Kanjana; Klaikeaw, Naruemon; Rerknimitr, Rungsun; Siriviriyakul, Prasong

2014-07-08

An overdose of the acetaminophen causes liver injury. This study aims to examine the anti-oxidative, anti-inflammatory effects of Aloe vera in mice with acetaminophen induced hepatitis. Male mice were randomly divided into three groups (n = 8 each). Control group were given orally distilled water (DW). APAP group were given orally N-acetyl-P-aminophenol (APAP) 400 mg/kg suspended in DW. Aloe vera-treated group were given orally APAP and Aloe vera (150 mg/kg) suspended in DW. Twenty-four hours later, the liver was removed to determine hepatic malondialdehyde (MDA), hepatic glutathione (GSH), the number of interleukin (IL)-12 and IL-18 positive stained cells (%) by immunohistochemistry method, and histopathological examination. Then, the serum was collected to determine transaminase (ALT). In APAP group, ALT, hepatic MDA and the number of IL-12 and IL-18 positive stained cells were significantly increased when compared to control group (1210.50 ± 533.86 vs 85.28 ± 28.27 U/L, 3.60 ± 1.50 vs 1.38 ± 0.15 nmol/mg protein, 12.18 ± 1.10 vs 1.84 ± 1.29%, and 13.26 ± 0.90 vs 2.54 ± 1.29%, P = 0.000, respectively), whereas hepatic GSH was significantly decreased when compared to control group (5.98 ± 0.30 vs 11.65 ± 0.43 nmol/mg protein, P = 0.000). The mean level of ALT, hepatic MDA, the number of IL-12 and IL-18 positive stained cells, and hepatic GSH in Aloe vera-treated group were improved as compared with APAP group (606.38 ± 495.45 vs 1210.50 ± 533.86 U/L, P = 0.024; 1.49 ± 0.64 vs 3.60 ± 1.50 nmol/mg protein, P = 0.001; 5.56 ± 1.25 vs 12.18 ± 1.10%, P = 0.000; 6.23 ± 0.94 vs 13.26 ± 0.90%, P = 0.000; and 10.02 ± 0.20 vs 5.98 ± 0.30 nmol/mg protein, P = 0.000, respectively). Moreover, in the APAP group, the liver showed extensive hemorrhagic hepatic necrosis at all zones while in Aloe vera-treated group, the liver architecture was improved histopathology. APAP overdose can cause liver injury. Our result indicate that Aloe vera attenuate APAP

Protective effect of gel form of gastric gavage applicated aloe vera on ischemia reperfusion injury in renal and lung tissue.

Science.gov (United States)

Sahin, Hasan; Yener, Ali Umit; Karaboga, Ihsan; Sehitoglu, Muserref Hilal; Dogu, Tugba; Altinisik, Hatice Betul; Altinisik, Ugur; Simsek, Tuncer

2017-12-30

The aloe vera plant has become increasingly popular in recent years. This study aimed to research the effect of aloe vera to prevent renal and lung tissue damage in an experimental ischemia-reperfusion (I/R) injury model. The study included 21 male Wistar Albino rats, which were categorized into control group, n = 7 (no procedures), Sham group n = 7 (I/R); and aloe vera therapy group, n = 7 (aloe vera and I/R). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) were evaluated from lung and kidney tissues for biochemical investigations. As histopathological, hematoxylin and eosin and anti-iNOS were also examined. In biochemical investigations, SOD, CAT, and GPx levels of the Sham group were found to be lower compared with the other groups (P < 0.05). The aloe vera therapy group was not statistically different from control groups but significantly different compared with the Sham group. In the same way, the MDA levels of kidney and lung tissues were statistically significant in the aloe vera therapy group, compared to the Sham group. In the Sham group, the peribronchial and perialveolar edema were observed in lung parenchyma. Also, excess interstitial hemorrhage, leukocyte infiltration, and alveolar wall thickening were identified in ischemic groups. The histopathological changes were much lighter than in the aloe vera therapy group. In renal tissues, excess epithelial cell deterioration, tubular desqumination, and glomerular atrophy were observed in the Sham group. The histopathological changes were markedly reduced in the aloe vera therapy  group. In the kidney and lung tissue, the level of iNOS activity in the Sham group was significantly higher than in the control and aloe vera therapy group. This study indicated that aloe vera is protective against oxidative damage formed by I/R in distant organs like the lungs and kidneys.

Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling: An Experimental Study.

Science.gov (United States)

Oryan, Ahmad; Mohammadalipour, Adel; Moshiri, Ali; Tabandeh, Mohammad Reza

2016-01-01

Treatment of large wounds is technically demanding and several attempts have been taken to improve wound healing. Aloe vera has been shown to have some beneficial roles on wound healing but its mechanism on various stages of the healing process is not clear. This study was designed to investigate the effect of topical application of A. vera on cutaneous wound healing in rats. A rectangular 2 × 2-cm cutaneous wound was created in the dorsum back of rats. The animals were randomly divided into 3 groups of control (n = 20), low-dose (n = 20), and high-dose (n = 20) A. vera. The control and treated animals were treated daily with topical application of saline, low-dose (25 mg/mL), and high-dose (50 mg/mL) A. vera gel, up to 10 days, respectively. The wound surface, wound contraction, and epithelialization were monitored. In each group, the animals were euthanized at 10 (n = 5), 20 (n = 5), and 30 (n = 10) days post injury (DPI). At 10, 20, and 30 DPI, the skin samples were used for histopathological and biochemical investigations; and at 30 DPI, the skin samples were also subjected for biomechanical studies. Aloe vera modulated the inflammation, increased wound contraction and epithelialization, decreased scar tissue size, and increased alignment and organization of the regenerated scar tissue. A dose-dependent increase in the tissue level of dry matter, collagen, and glycosaminoglycans' content was seen in the treated lesions, compared to the controls. The treated lesions also demonstrated greater maximum load, ultimate strength, and modulus of elasticity compared to the control ones (P vera improved the biochemical, morphological, and biomechanical characteristics of the healing cutaneous wounds in rats. This treatment option may be valuable in clinical practice.

The effect of Aloe vera bioactive and anthraquinone on the performance of laying hens

Directory of Open Access Journals (Sweden)

Tiurma Pasaribu

2005-10-01

Full Text Available An experiment was conducted to study the use of Aloe vera bioactives as feed additives on the performances of laying hens. The Aloe vera bioactives was prepared as the dry gel (DG and semi liquid gel (SLG. The Aloe vera was suplemented into the diets with concentration of equal to 0.5 and 1.0 g DG/kg diets. Diets contained commercial anthraquinone, a bioactive compound of Aloe vera with doses equal to 0.5 g DG and 1.0 dg/kg were also prepared. Diets were compared to control diets containing with and without antibiotic. Two hundred of fifty six laying hens strain Isa Brown aged 19 weeks were used for the experiment. Each treatment had 8 replicates with 4 hens in each replicate. The treatments were carried out for 30 weeks and parameters measured were egg production (% hen day/HD, egg weight, feed conversion ratio (FCR, feed consumption, egg quality, and mortality. Results showed that feed consumption was not significantly different (P>0.05, however DG 1.0 g/kg and anthraquinone 0.5 g/kg tended to decrease the feed consumption. Egg production was not significantly affected by antibiotic, DG, SLG, or anthraquinone (0.5 g/kg, but anthraquinone 1.0 g/kg had more egg production than control. Higher concentration of DG, SLG, and anthraquinone 1.0 g/kg gave better FCR than those of lower dosage (0.5 g/kg. Haugh unit was not affected by the treatment while yolk weight, egg shell and shell weight was significantly decreased by anthraquinone 0.5 g/kg (P<0.05. Mortality from all treatments was only 1.6%. It was concluded that treated by anthraquinone was better than that by Aloe vera, however, they were not significantly different. For the healthy reason, the use of Aloe vera is more saver than the use of anthraquinone.

Pharmacological attribute of Aloe vera: Revalidation through experimental and clinical studies

Science.gov (United States)

Gupta, Vinay K.; Malhotra, Seema

2012-01-01

Aloe vera has long been used as a traditional medicine for inducing wound healing. It is a natural product that now a days is used in cosmetic industry. Benefits associated with Aloe vera have been attributed to the polysaccharides contained in the gel of the leaves though there are various indications for its use. Biological activities include promotion of wound healing, antifungal activity, anti-inflammatory, anticancer and immunomodulatory. Gingival fibroblasts play an important role in oral wound healing. Double blind-controlled trials are needed to determine its real efficacy in oral health. PMID:23559789

Pemanfaatan Ekstrak Andrographis Paniculata Nees Dan Aloe Vera L Sebagai Anti Inflamas

OpenAIRE

Evacuasiany W., Endang; Soebiantoro, Freddy

2002-01-01

Telah dilakukan pengujian terhadap tanaman Andrographis paniculata Nees dan Aloe Vera L dengan metoda artritis eksperimental pada tikus putih galur Wistar. Hasil percobaan menunjukkan adanya efek inhibisi radang yang diinduksi oleh karagenin lambda. Ekstrak etanol Andrographis paniculata Nees bermakna (p=0.05) pada dosis 0.9 g/kg BB dan Aloe vera L memberikan efek inhibisi radang pada dosis 1.5 g/kg BB (p=0.05). Pengujian dilakukan pada dosis yang bervariasi. Ternyata efek yang ditimbulkan te...

In Vitro and In Vivo Antileishmanial Activities of Pistacia vera Essential Oil.

Science.gov (United States)

Mahmoudvand, Hossein; Saedi Dezaki, Ebrahim; Ezatpour, Behrouz; Sharifi, Iraj; Kheirandish, Farnaz; Rashidipour, Marzieh

2016-03-01

This study aims to evaluate the in vitro and in vivo antileishmanial activities of Pistacia vera essential oil and compare their efficacy with a reference drug, meglumine antimoniate (Glucantime®). This essential oil (0-100 µg/mL) was evaluated in vitro against the intracellular amastigote forms of Leishmania tropica (MHOM/IR/2002/Mash2) and then tested on cutaneous leishmaniasis of male BALB/c mice by Leishmania major (MRHO/IR/75/ER). In the in vitro assay, it could be observed that P. vera essential oil significantly (p essential oil had potent suppression effects on cutaneous leishmaniasis in BALB/c mice (87.5% recovery), while 10 and 20 mg/mL of the essential oil represented the suppression effects as weak to intermediate. The mean diameter of the lesions decreased about 0.11 and 0.27 cm after the treatment of the subgroups with the essential oil concentrations of 10 and 20 mg/mL, respectively. In contrast, in the subgroup treated with the essential oil concentration of 30 mg/mL, the mean diameter of the lesions decreased about 0.56 cm. In the control subgroups, the mean diameter of the lesions increased to 1.01 cm. The main components of P. vera essential oil were limonene (26.21%), α-pinene (18.07%), and α-thujene (9.31%). It was also found that P. vera essential oil had no significant cytotoxic effect on J774 cells. The present study found that P. vera essential oil showed considerable in vitro and in vivo effectiveness against L. tropica and L. major compared to the reference drug. These findings also provided the scientific evidence that natural plants could be used in traditional medicine for the prevention and treatment of cutaneous leishmaniasis. Georg Thieme Verlag KG Stuttgart · New York.

Ribosomal DNA sequence analysis of different geographically distributed Aloe Vera plants: Comparison with clonally regenerated plants

International Nuclear Information System (INIS)

Yagi, A.; Sato, Y.; Miwa, Y.; Kabbash, A.; Moustafa, S.; Shimomura, K.; El-Bassuony, A.

2006-01-01

A comparison of the sequences in an internally transcribed spacer (ITS) 1 region of rDNA between clonally regenerated A.vera and same species in Japan, USA and Egypt revealed the presence of two types of nucleotide sequences, 252 and 254 bps. Based on the findings in the ITS 1 region, A.vera having 252 and 254 bps clearly showed a stable sequence similarity, suggesting high conversation of the base peak sequence in the ITS 1 region. However, frequent base substitutions in the 252 bps samples leaves that came from callus tissue and micropropagated plants were observed around the regions of nucleotide positions 66, 99 and 199-201. The minor deviation in clonally regenerated A.vera may be due to the stage of regeneration and cell specification in cases of the callus tissue. In the present study, the base peak sequence of the Its 1 region of rDNA was adopted as a molecular marker for differentiating A.vera plants from geographically distributed and clonally regenerated A.vera plants and it was suggested that the base peak substitutions in the ITS 1 region may arise from the different nutritional and environmental factors in cultivation and plant growth stages. (author)

Antiplatelet drugs for polycythaemia vera and essential thrombocythaemia

NARCIS (Netherlands)

Squizzato, A.; Romualdi, E.; Middeldorp, S.

2008-01-01

BACKGROUND: Polycythaemia vera and essential thrombocythaemia are chronic Philadelphia-negative myeloproliferative disorders, which increase the risk of arterial and venous thrombosis as well as bleeding. In addition to the different therapeutic strategies available, aspirin is often used to prevent

Development of Aloe vera based edible coating for tomato

Science.gov (United States)

Athmaselvi, K. A.; Sumitha, P.; Revathy, B.

2013-12-01

The effect of formulated Aloe vera based edible coating on mass loss, colour, firmness, pH, acidity, total soluble solid, ascorbic acid and lycopene on the coated tomato was investigated. The tomato in control showed a rapid deterioration with an estimated shelf life period of 19 days, based on the mass loss, colour changes, accelerated softening and ripening. On the contrary, the coating on tomatoes delayed the ripening and extended the shelf life up to 39 days. The physiological loss in weight was 7.6 and 15.1%, firmness was 36 and 46.2 N on 20th day for control and coated tomatoes, respectively. From the results, it was concluded that the use of Aloe vera based edible coating leads to increased tomato shelf-life.

Aspectos neurológicos da policitemia vera

Directory of Open Access Journals (Sweden)

Roberto Melaragno Filho

1955-12-01

Full Text Available Neste trabalho são apresentados os 8 casos de policitemia vera internados no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo desde sua fundação, em 1944, até junho de 1955, sôbre um total de 147.749 pacientes. Em todos os casos havia sintomas ou sinais imputáveis a acometimento do sistema nervoso. Em 5 pacientes os sintomas eram apenas subjetivos, consistindo em cefaléia, tonturas e astenia; em apenas um dêsses 5 casos há referências anamnésticas a hemiparesia transitória esquerda. Em 3 dêsses 5 casos foi registrada congestão venosa retiniana; em um o fundo de ôlho foi normal; no último êste exame não foi feito. Nos 3 pacientes restantes, ao lado de idênticos sintomas subjetivos, havia sinais neurológicos focais. No primeiro (caso 6, havia sinais de oclusão da artéria cerebral média esquerda; no segundo (caso 7, havia paraplegia motora e sensitiva por lesão medular; o último (caso 8, apresentava os elementos constitutivos da síndrome de Wallemberg, por oclusão da artéria cerebelar póstero-inferior esquerda. Na bibliografia consultada, os autores não encontraram referência a casos semelhantes aos de suas duas últimas observações. Referindo as hipóteses patogênicas que procuram relacionar a policitemia vera à lesões diencefálicas ou à presença de hemangioblastomas intracranianos, os autores admitem que a ocorrência de distúrbios neurológicos na vigência da policitemia vera deve ser atribuída a diversos fatôres, destacando-se o aumento da viscosidade sangüínea, com aumento de resistência cérebro-vascular e diminuição do fluxo e velocidade do sangue no encéfalo, e a arteriosclerose, cujo desenvolvimento parece ser favorecido pela condição policitêmica. Os autores aventam a hipótese de que a paraplegia sensitivo-motora registrada em um de seus casos (caso 7 seja devida a um angioma intra-raquidiano, análogo aos tumores vasculares intracranianos que, com certa

ALOE VERA BARBADENSIS MILLER AS AN ALTERNATIVE TREATMENT FOR CHILDREN WITH FEVER

Directory of Open Access Journals (Sweden)

Siti Choirul Dwi Astuti

2017-10-01

Full Text Available Background: Applying a cooling treatment from outside the body is one way to lower fever in children. Midwives commonly perform a warm water compress in their care, but it is considered less effective. Thus, compress with aloe vera barbadensus miller is proposed in this study as an alternative treatment. Objective: To examine the effect of Aloe vera barbadensis miller compress in reducing body temperature in children with fever. Methods: This was a quasi-experimental study with pretest and posttest with control group design. Forty children were recruited, with twenty of them assigned in each group. Purposive sampling was performed to select the sample. A digital rectal thermometer was used to measure the temperature. Independent t- test and paired test were used for data analysis. Results: Findings showed that the aloe vera compress group showed a higher decrease of body temperature compared to the warm water compress group. The difference of body temperature after 20 minutes in the experiment group was 1.435 while in the control group was only 1.085. There were statistically significant differences in body temperature between the experiment and control group (p=0.013. Conclusion: Aloe vera barbadensis miller compress is an effective alternative therapy in reducing body temperature in children with fever. It is recommended for midwives to apply this intervention to reduce body temperature significantly.

POLYCYTHEMIA VERA AN EXAMPLE OF A CLINICAL CASE

Directory of Open Access Journals (Sweden)

E. E. Tomina

2015-06-01

Full Text Available The article concerns a clinical case management of patients with polycythemia vera. The data are given from the laboratory and instrumental diagnostic methods, clinical diagnosis, selection of the optimized treatment and modification of the habit of life.

Uncertainty quantification and sensitivity analysis with CASL Core Simulator VERA-CS

International Nuclear Information System (INIS)

Brown, C.S.; Zhang, Hongbin

2016-01-01

VERA-CS (Virtual Environment for Reactor Applications, Core Simulator) is a coupled neutron transport and thermal-hydraulics code under development by the Consortium for Advanced Simulation of Light Water Reactors (CASL). An approach to uncertainty quantification and sensitivity analysis with VERA-CS was developed and a new toolkit was created to perform uncertainty quantification and sensitivity analysis. A 2 × 2 fuel assembly model was developed and simulated by VERA-CS, and uncertainty quantification and sensitivity analysis were performed with fourteen uncertain input parameters. The minimum departure from nucleate boiling ratio (MDNBR), maximum fuel center-line temperature, and maximum outer clad surface temperature were chosen as the selected figures of merit. Pearson, Spearman, and partial correlation coefficients were considered for all of the figures of merit in sensitivity analysis and coolant inlet temperature was consistently the most influential parameter. Parameters used as inputs to the critical heat flux calculation with the W-3 correlation were shown to be the most influential on the MDNBR, maximum fuel center-line temperature, and maximum outer clad surface temperature.

Development Prospect of Aloe Vera Plant in Peatlands in West Kalimantan

Directory of Open Access Journals (Sweden)

Tommy Purba

2016-04-01

Full Text Available Peat soil is one of the decent growing medium for aloe vera plant. Seeing the potential of peat land in West Kalimantan is quite extensive, this plant is cultivated commercially and becomes one of the leading commodity in peatlands in West Kalimantan, especially in Pontianak City with an area of more than 25,000 ha. With complete and varied nutrient content, this plant progress opportunities, especially for diversification is enormous ranging from food products and beverages such as juices, cocktails, aloe vera gel in syrup, jams, jellies, tarts, sweets, tea, chips and as well as agro-tourism in West Kalimantan. Existing obstacles now are market share and unstable price, trouble controlling plant diseases and peat area is flooded during the rainy season. Prospects for the future development of these plants can be carried out through the cooperation of government and relevant stakeholders,stable markets and prices, the acceleration of product promotion through fairs and business gathering activities, as well as the dissemination and application of cultivation technology and post-harvest of aloe vera.

Efficacy of Aloe Vera Cream in the Treatment of Paederus Dermatitis in Mice

Directory of Open Access Journals (Sweden)

Ramin Khaghani

2017-06-01

Full Text Available Background: Dermatitis caused by Paederus beetle involves many people around the world, especially Iran. The symptoms include redness, itching and severe irritation. This study evaluated the effectiveness of the Aloe vera cream on the treatment of dermatitis caused by Paederus beetles.Methods: Forty male 6–8 weeks BALB/C mice were randomly divided into four groups of 10 mice. After removing the mice’s back hair, the backs of mice were marked by a circle with a diameter of 3 mm. The Paederus beetles were collected from Babol in Mazandaran Province, northern Iran and transferred to the animal lab of Aja University of Medical Sciences, Tehran, Iran. The end of abdominal segment Paederus was cut with scissors and hemolymph content was pushed by forceps on the circle. Only hemolymph of one Paederus applied to the back of each mouse. Groups 1, 2, 3 and 4 were treated with the base (vehicle, dexamethasone 0.1%, Aloe vera 0.5% and Aloe vera 2% creams respectively. After 2 days, dermatitis appeared. Then the mentioned creams were applied on the mice once a day. The wound area was measured every day. Dermatitis surface area under curve (AUC of each mouse was cal­culated for 17 days after induction of dermatitis. Statistical analysis of ANOVA was used.Results: Application of Aloe vera 0.5% and 2% significantly reduced the healing duration and dermatitis area in comparison with the vehicle and dexamethasone cream (P< 0.05. But dexamethasone had no significant effect on the healing of dermatitis as compared to vehicle.Conclusion: Aloe vera may clinically effective in the treatment of Paederus dermatitis.

From leeches to personalized medicine: evolving concepts in the management of polycythemia vera

Science.gov (United States)

Vannucchi, Alessandro M.

2017-01-01

Polycythemia vera is a clonal disorder of hematopoietic stem/progenitor cells. It manifests as an expansion of red cell mass. It is the most common chronic myeloproliferative neoplasm. In virtually all cases, it is characterized by a V617F point mutation in JAK2 exon 14 or less common mutations in exon 12. The landmark discovery of the autonomously activated JAK/STAT signaling pathway paved the way for the clinical development of the first target drug, the JAK1 and JAK2 inhibitor ruxolitinib. This is now approved for patients with resistance or intolerance to hydroxyurea. Phlebotomies and hydroxyurea are still the cornerstone of treatment, and aim to prevent the first appearance or recurrence of cardiovascular events that, together with progression to post-polycythemia vera myelofibrosis and leukemia, represent the main causes of death. Interferon-α is an alternative drug and has been shown to induce molecular remissions. It is currently undergoing phase III trials that might eventually lead to its approval for clinical use. The last few years have witnessed important advances towards an accurate early diagnosis of polycythemia vera, greater understanding of its pathogenesis, and improved patient management. This review will focus on the most recent achievements and will aim to unify the different concepts involved in a personalized approach to the patient with polycythemia vera. In spite of many recent advances in the understanding of its pathogenesis and improved disease management, polycythemia vera remains a life-threatening myeloproliferative neoplasm for which there is no cure. This review will present a critical overview of evolving concepts in diagnosis and treatment of this disease. PMID:27884974

Effect Of Aloe Vera Juice On Hyperglycemia And ATHEROGENICITY In Diabetic Rats

International Nuclear Information System (INIS)

ABDEL-AZIZ, A.F.; EZZ-ELARAB, A.; EL-SHERBINY, E.M.; MORSI, R.M.

2009-01-01

Diabetes mellitus is the most prevalent chronic disease and cause death in many countries. The present study aims to study the efficacy of Aloe vera whole leaf juice filtrate to ameliorate the glucose level and lipid profile status in four groups of female diabetic rats. Serum glucose, total cholesterol, HDL-cholesterol, anti-atherogenic index (AAI), TBARs and insulin levels were determined in all groups. There was very highly significant increase in serum glucose, cholesterol, and TBARs levels in diabetic group as compared to the control. Oral administration of Aloe vera juice filtrate resulted in a very highly significant decrease in serum glucose, cholesterol and TBARs levels when compared to that of diabetic group. Serum HDL-cholesterol, insulin level and anti-atherogenic index were very highly significantly decreased in diabetic rats as compared to the control, whereas these parameters were highly significantly increased after the oral administration of Aloe vera juice filtrate as compared to diabetic group

RBF neural network prediction on weak electrical signals in Aloe vera var. chinensis

Science.gov (United States)

Wang, Lanzhou; Zhao, Jiayin; Wang, Miao

2008-10-01

A Gaussian radial base function (RBF) neural network forecast on signals in the Aloe vera var. chinensis by the wavelet soft-threshold denoised as the time series and using the delayed input window chosen at 50, is set up to forecast backward. There was the maximum amplitude at 310.45μV, minimum -75.15μV, average value -2.69μV and Aloe vera var. chinensis respectively. The electrical signal in Aloe vera var. chinensis is a sort of weak, unstable and low frequency signals. A result showed that it is feasible to forecast plant electrical signals for the timing by the RBF. The forecast data can be used as the preferences for the intelligent autocontrol system based on the adaptive characteristic of plants to achieve the energy saving on the agricultural production in the plastic lookum or greenhouse.

Prolonged bone marrow T1-relaxation in patients with polycythemia vera

DEFF Research Database (Denmark)

Jensen, K E; Grube, T; Thomsen, C

1988-01-01

In vitro as well as in vivo studies have shown prolonged T1 relaxation times in patients with acute leukemia. The mechanism behind this finding is not known. In order to evaluate if this was specific for leukemia we examined eight patients with polycythemia vera, representing a condition with a r......In vitro as well as in vivo studies have shown prolonged T1 relaxation times in patients with acute leukemia. The mechanism behind this finding is not known. In order to evaluate if this was specific for leukemia we examined eight patients with polycythemia vera, representing a condition...

Mechanism of Aloe Vera extract protection against UVA: shelter of lysosomal membrane avoids photodamage.

Science.gov (United States)

Rodrigues, Daniela; Viotto, Ana Cláudia; Checchia, Robert; Gomide, Andreza; Severino, Divinomar; Itri, Rosangela; Baptista, Maurício S; Martins, Waleska Kerllen

2016-03-01

The premature aging (photoaging) of skin characterized by wrinkles, a leathery texture and mottled pigmentation is a well-documented consequence of exposure to sunlight. UVA is an important risk factor for human cancer also associated with induction of inflammation, immunosuppression, photoaging and melanogenesis. Although herbal compounds are commonly used as photoprotectants against the harmful effects of UVA, the mechanisms involved in the photodamage are not precisely known. In this study, we investigated the effects of Aloe Vera (Aloe barbadensis mil) on the protection against UVA-modulated cell killing of HaCaT keratinocytes. Aloe Vera exhibited the remarkable ability of reducing both in vitro and in vivo photodamage, even though it does not have anti-radical properties. Interestingly, the protection conferred by Aloe Vera was associated with the maintenance of membrane integrity in both mimetic membranes and intracellular organelles. The increased lysosomal stability led to a decrease in lipofuscinogenesis and cell death. This study explains why Aloe Vera extracts offer protection against photodamage at a cellular level in both the UV and visible spectra, leading to its beneficial use as a supplement in protective dermatological formulations.

Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study.

Science.gov (United States)

Anuradha, Ardra; Patil, Bharati; Asha, Venkataswamy Reddy

2017-01-01

Oral submucous fibrosis is a chronic disease, treatment of which has largely been symptomatic. Aloe vera has immunomodulatory, anti-inflammatory, wound healing, antioxidant, and antineoplastic activities. All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis. Seventy-four patients of oral submucous fibrosis were randomly divided into 2 groups. Group A patients were treated with systemic (juice) and topical aloe vera (gel) for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with antioxidant supplements for 3 months. Patients were assessed for reduction in burning sensation and increase in mouth opening, cheek flexibility, and tongue protrusion at an interval of 1, 2, and 3 months. Both the groups showed statistically significant improvements in all the study parameters at the end of study period (P aloe vera was comparable to that of intralesional injections of hydrocortisone and hyaluronidase with antioxidant supplementation. The study concludes that aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis. Long-term follow-up studies with larger sample size are recommended. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.

Science.gov (United States)

Crielaard, Bart J; Rivella, Stefano

2014-06-01

β-Thalassemia and Polycythemia vera are genetic disorders which affect the synthesis of red blood cells, also referred to as erythropoiesis. Although essentially different in clinical presentation - patients with β-thalassemia have an impairment in β-globin synthesis leading to defective erythrocytes and anemia, while patients with Polycythemia vera present with high hemoglobin levels because of excessive red blood cell synthesis - both pathologies may characterized by lasting high erythropoietic activity, i.e. chronic stress erythropoiesis. In both diseases, therapeutic strategies targeting chronic stress erythropoiesis may improve the address phenotype and prevent secondary pathology, such as iron overload. The current review will address the basic concepts of these strategies to reduce chronic stress erythropoiesis, which may have significant clinical implications in the near future. Copyright © 2014 Elsevier Ltd. All rights reserved.

Optimal therapy for polycythemia vera and essential thrombocythemia

DEFF Research Database (Denmark)

Silver, Richard T; Hasselbalch, Hans K

2016-01-01

Objectives: To determine the value of recombinant interferon-alfa (rIFNα) in the treatment of polycythemia vera (PV) and essential thrombocythemia (ET) based on its biological activities and phase 2 clinical studies, pending completion of phase 3 trials; to determine importance of the Internet...

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Science.gov (United States)

Budai, Marietta M; Varga, Aliz; Milesz, Sándor; Tőzsér, József; Benkő, Szilvia

2013-12-01

Aloe vera has been used in traditional herbal medicine as an immunomodulatory agent inducing anti-inflammatory effects. However, its role on the IL-1β inflammatory cytokine production has not been studied. IL-1β production is strictly regulated both at transcriptional and posttranslational levels through the activity of Nlrp3 inflammasome. In this study we aimed to determine the effect of Aloe vera on the molecular mechanisms of Nlrp3 inflammasome-mediated IL-1β production in LPS-activated human THP-1 cells and monocyte-derived macrophages. Our results show that Aloe vera significantly reduced IL-8, TNFα, IL-6 and IL-1β cytokine production in a dose dependent manner. The inhibitory effect was substantially more pronounced in the primary cells. We found that Aloe vera inhibited the expression of pro-IL-1β, Nlrp3, caspase-1 as well as that of the P2X7 receptor in the LPS-induced primary macrophages. Furthermore, LPS-induced activation of signaling pathways like NF-κB, p38, JNK and ERK were inhibited by Aloe vera in these cells. Altogether, we show for the first time that Aloe vera-mediated strong reduction of IL-1β appears to be the consequence of the reduced expression of both pro-IL-1β as well as Nlrp3 inflammasome components via suppressing specific signal transduction pathways. Furthermore, we show that the expression of the ATP sensor P2X7 receptor is also downregulated by Aloe vera that could also contribute to the attenuated IL-1β cytokine secretion. These results may provide a new therapeutic approach to regulate inflammasome-mediated responses. Copyright © 2013 Elsevier Ltd. All rights reserved.

The increasing of fibroblast growth factor 2, osteocalcin, and osteoblast due to the induction of the combination of Aloe vera and 2% xenograft concelous bovine

Directory of Open Access Journals (Sweden)

Utari Kresnoadi

2012-12-01

Full Text Available Background: To make a successfull denture prominent ridge is needed, preservation on tooth extraction socket is needed in order to prevent alveol bone resorption caused by revocation trauma. An innovative modification of the material empirically suspected to be able reduce inflammation caused by the revocation trauma is a combination of Aloe vera and xenograft concelous bovine (XCB and Aloe vera is a biogenic stimulator and accelerating the growth of alveolar ridge bone after tooth extraction. Purpose: The research was aimed to determine of the increasing alveol bone formation by inducing the combination of Aloe vera and 2% xenograft concelous bovine. Methods: To address the problems, the combination of Aloe vera and xenograft concelous bovine was induced into the tooth extraction sockets of Cavia cabayas which devided on 8 groups. Groups control, filled with XCB, Aloe vera and Aloe vera and XCB combination, at 7 days and 30 days after extraction. Afterwards, immunohistochemical examination was conducted to examine the expressions of FGF-2 and osteocalcin, as the product of the growth of osteoblasts. Results: There were significantly increases expression of FGF-2 and osteocalcyn on group which filled with XCB, Aloe vera and combined Aloe vera and XCB. Conclusion: It may be concluded that the induction of the combination of Aloe vera and xenograft concelous bovine into the tooth sockets can enhance the growth expressions of FGF-2 and osteocalcin as the product of osteoblasts, thus, the growth of alveolar bone was increased.Latar belakang: Untuk keberhasilan pembuatan gigitiruan diperlukan ridge yang prominent, maka diperlukan suatu preservasi soket pencabutan gigi untuk mencegah terjadinya resopsi tulang alveolar akibat trauma pencabutan. Suatu inovasi modifikasi bahan yang diduga secara empiris dapat mengurangi keradangan karena trauma pencabutan adalah berupa kombinasi Aloe vera dan xenograft concelous bovine (XCB. Aloe vera yang merupakan

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia

Directory of Open Access Journals (Sweden)

Leonardo Caires dos Santos

2011-12-01

Full Text Available BACKGROUND: The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVE: The aim of this study was to detect the following mutations: JAK2 V617F, JAK2 exon 12 and MPL W515K/L, besides chromosomal abnormalities. Furthermore, molecular and cytogenetic alterations were correlated with the leukocyte and platelet counts, hemoglobin levels and age in all patients and with the degree of fibrosis in primary myelofibrosis cases. METHODS: Twenty cases of polycythemia vera, 17 of essential thrombocythemia and 21 of primary myelofibrosis were selected in the Hematology Department of the Universidade Federal de São Paulo (UNIFESP between February 2008 and December 2009. The JAK2 V617F, JAK2 exon 12 mutations, MPL W515K and MPL W515L mutations were investigated by real-time PCR and direct sequencing. G-band karyotyping and fluorescence in situ hybridization were used to detect chromosomal abnormalities. RESULTS: Chromosomal abnormalities were observed only in polycythemia vera (11.8% and primary myelofibrosis cases (17.6%, without correlation to clinical data. Chromosomal abnormalities were not detected by fluorescence in situ hybridization. The JAK2 V617F mutation was observed in polycythemia vera (90%, primary myelofibrosis (42.8% and essential thrombocythemia (47%. Patients with JAK2 V617F-negative polycythemia vera had lower platelet and leukocyte counts compared to V617F-positive polycythemia vera (p-value = 0.0001 and p-value = 0.023, respectively. JAK2 V617F-positive and MPL W515L-positive primary myelofibrosis cases had a higher degree of fibrosis than V617F-negative cases (p-value = 0.022. JAK2 exon 12 mutations were not detected in polycythemia vera patients. The MPL W515L mutation was observed in one case of primary myelofibrosis and in one of essential thrombocythemia. The MPL W515K mutation was not found in patients with essential thrombocythemia

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia.

Science.gov (United States)

Dos Santos, Leonardo Caires; Ribeiro, Juliana Corrêa da Costa; Silva, Neusa Pereira; Cerutti, Janete; da Silva, Maria Regina Regis; Chauffaille, Maria de Lourdes Lopes Ferrari

2011-01-01

The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. THE AIM OF THIS STUDY WAS TO DETECT THE FOLLOWING MUTATIONS: JAK2 V617F, JAK2 exon 12 and MPL W515K/L, besides chromosomal abnormalities. Furthermore, molecular and cytogenetic alterations were correlated with the leukocyte and platelet counts, hemoglobin levels and age in all patients and with the degree of fibrosis in primary myelofibrosis cases. Twenty cases of polycythemia vera, 17 of essential thrombocythemia and 21 of primary myelofibrosis were selected in the Hematology Department of the Universidade Federal de São Paulo (UNIFESP) between February 2008 and December 2009. The JAK2 V617F, JAK2 exon 12 mutations, MPL W515K and MPL W515L mutations were investigated by real-time PCR and direct sequencing. G-band karyotyping and fluorescence in situ hybridization were used to detect chromosomal abnormalities. Chromosomal abnormalities were observed only in polycythemia vera (11.8%) and primary myelofibrosis cases (17.6%), without correlation to clinical data. Chromosomal abnormalities were not detected by fluorescence in situ hybridization. The JAK2 V617F mutation was observed in polycythemia vera (90%), primary myelofibrosis (42.8%) and essential thrombocythemia (47%). Patients with JAK2 V617F-negative polycythemia vera had lower platelet and leukocyte counts compared to V617F-positive polycythemia vera (p-value = 0.0001 and p-value = 0.023, respectively). JAK2 V617F-positive and MPL W515L-positive primary myelofibrosis cases had a higher degree of fibrosis than V617F-negative cases (p-value = 0.022). JAK2 exon 12 mutations were not detected in polycythemia vera patients. The MPL W515L mutation was observed in one case of primary myelofibrosis and in one of essential thrombocythemia. The MPL W515K mutation was not found in patients with essential thrombocythemia or primary myelofibrosis. The MPL W515L

The effects of crude aqueous and alcohol extracts of Aloe vera on growth and abdominal viscera of suckling rats.

Science.gov (United States)

Beya, Wabeya; Davidson, Bruce; Erlwanger, Kennedy H

2012-01-01

The gastrointestinal tract of neonates is sensitive to dietary manipulations. When nursing mothers use Aloe vera, their babies are at risk of indirect exposure to Aloe vera via breast feeding or directly as health supplements. The effects of orally administered extracts of Aloe vera in unweaned rats were investigated. Six day old Sprague-Dawley rats were gavaged with aqueous or alcohol extracts of Aloe vera (low dose 50mg. kg⁻¹ or high dose 500mg. kg⁻¹) daily for eight days. All data were expressed as mean ± SD and analyzed by one way ANOVA. Pups receiving high doses of either extract had a significantly higher body mass gain than the group receiving lower dose (p Aloe vera extracts resulted in growth promotion, enhanced hepatic storage of metabolic substrates, increased ALP possibly in relation to bone growth and caused hypertrophy of the caecum of neonatal rats. These effects need to be explored further to enhance animal production and health.

[Hungarian Philadelphia negative chronic myeloproliferative neoplasia registry. Evaluation of the Polycythemia vera patients].

Science.gov (United States)

Dombi, Péter; Illés, Árpád; Demeter, Judit; Homor, Lajos; Simon, Zsófia; Kellner, Ádám; Karádi, Éva; Valasinyószki, Erika; Udvardy, Miklós; Egyed, Miklós

2017-06-01

Intruduction and aim: The Hungarian National Registry for Philadelphia chromosome negative myeloproliferative neoplasms has been developed. The aim of the recent study is to assess the clinical characteristics of Hungarian patients with polycythemia vera. Data of 351 JAK2 V617F and exon 12 mutation positive polycythemia vera patients were collected online from 15 haematology centres reporting epidemiologic, clinical characteristics, diagnostic tools, therapeutic interventions, thromboembolic complications, disease transformations. Vascular events prior to and after diagnosis were evaluated upon the Landolfi risk assessment scale. 116 thromboembolic events were reported in 106 PV patients prior to diagnosis and 152 occasions in 102 patients during follow-up. The frequency of major arterial events were significantly reduced (ppolycythemia vera. The Landolfi risk stratification was proven to be useful. Based on evaluated data, accuracy of diagnostic criteria and compliance to risk-adapted therapeutic guidelines are needed. Orv Hetil. 2017; 158(23): 901-909.

Gamma irradiation response of RBC in presence of Aloe vera leaf extract

International Nuclear Information System (INIS)

Rane, Charusheela C.; Patil, Shilpa M.; Kulkarni, Satish G.

2004-01-01

Full text: The components from fleshy leaves of Aloe vera have wide range of utility in treating human aliments owing to their medicinal property including antioxidant characteristic. During gamma irradiation, attack by free radicals is the prominent cause of damage to cell membrane. This action is modified to varied extent by several components from plants. A radio modulation effect of different dilutions of Aloe vera leave extract against gamma radiation has been evaluated by measuring percent haemolysis. The result obtained will be discussed to narrate influencing role of various factors in modulation

Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer

Science.gov (United States)

Shirali, Saeed; Barari, Alireza; Hosseini, Seyed Ahmad; Khodadi, Elaheh

2017-01-01

The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate. Aloe Vera extract at a dose of 300 mg/kg BW was administrated to rats by intraperitoneal injection. At the end of the study period, rats were anesthetized and blood samples were taken. Significant differences were concluded at pAloe Vera extract caused significant decrease in the COX-2 level in the cancer group. Also, in the training (swimming exercise) and Aloe Vera + training cancer groups, we observed significant decrease in the VEGF level as compared to controls. Our results suggest that Aloe Vera and training inhibit the COX pathway and cause decrease production of prostaglandin E2. Hence administration of Aloe Vera in combination with endurance training might synergistically improve the host milieu in mice bearing breast cancers. Creative Commons Attribution License

Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications.

Science.gov (United States)

Balaji, Arunpandian; Jaganathan, Saravana Kumar; Supriyanto, Eko; Muhamad, Ida Idayu; Khudzari, Ahmad Zahran Md

2015-01-01

Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

Dynamical Downscaling of Typhoon Vera (1959) and related Storm Surge based on JRA-55 Reanalysis

Science.gov (United States)

Ninomiya, J.; Takemi, T.; Mori, N.; Shibutani, Y.; Kim, S.

2015-12-01

Typhoon Vera in 1959 is historical extreme typhoon that caused severest typhoon damage mainly due to the storm surge up to 389 cm in Japan. Vera developed 895 hPa on offshore and landed with 929.2 hPa. There are many studies of the dynamical downscaling of Vera but it is difficult to simulate accurately because of the lack of the accuracy of global reanalysis data. This study carried out dynamical downscaling experiment of Vera using WRF downscaling forced by JRA-55 that are latest atmospheric model and reanalysis data. In this study, the reproducibility of five global reanalysis data for Typhoon Vera were compered. Comparison shows that reanalysis data doesn't have strong typhoon information except for JRA-55, so that downscaling with conventional reanalysis data goes wrong. The dynamical downscaling method for storm surge is studied very much (e.g. choice of physical model, nudging, 4D-VAR, bogus and so on). In this study, domain size and resolution of the coarse domain were considered. The coarse domain size influences the typhoon route and central pressure, and larger domain restrains the typhoon strength. The results of simulations with different domain size show that the threshold of developing restrain is whether the coarse domain fully includes the area of wind speed more than 15 m/s around the typhoon. The results of simulations with different resolution show that the resolution doesn't affect the typhoon route, and higher resolution gives stronger typhoon simulation.

A review on ethnopharmacological potential of Aloe vera L.

Directory of Open Access Journals (Sweden)

Md. Shamim Hossain

2013-04-01

Full Text Available In recent years, Aloe vera Linn. (Ghritokumari locally has become a subject of interest because of its beneficial effects on human health. The present ethnopharmacological review was conducted to evaluate the therapeutic properties of A. vera by scientific evidences. It belongs to the family Liliaceae, is a perennial herb with 30-60cm long juicy leaves which is found all over Bangladesh. To date, more than 75 active ingredients including aloesin, aloeemodin, acemannan, aloeride, methylchromones, flavonoids, saponin, amino acids, vitamins, and minerals have been identified from inner gel of leaves. It has antiinflammatory, antioxidant, antimicrobial, anticancer, antidiabetic, immuneboosting, and hypoglycemic properties. Daily supplementation with this is effective against stroke, heart attacks, leukemia, anemia, hypertension, AIDS, radiation burns, digestive disorders etc. This study also covers its taxonomy, distribution, morphology, and monograph. [J Intercult Ethnopharmacol 2013; 2(2.000: 113-120

Effect of Aloe vera on some indicators of cell damage after a period of aerobic exercise in male athletes

Directory of Open Access Journals (Sweden)

Barati Amir-Hosein

2015-07-01

Full Text Available Introduction: Aloe vera is a medicinal plant with antioxidant activity. The purpose of this study was to determine the effect of Aloe vera on some indicators of cell damage after a period of aerobic exercise in male athletes of 15-18 years old. Methods: In this clinical trial study, 20 male students with average weight of 64.85 ± 51 and height of 172.05 ± 6.4 were randomly assigned to 2 groups of Aloe vera supplement (n = 10 and placebo (n = 10. Then aerobic training was conducted for 4 weeks. The supplemented group took 3 capsules, each capsule contains 2 g of dried Aloe vera and placebo group took 3 capsules/day containing dextran after every meal. To determine the index of cell injury markers creatine kinase (CK, lactate dehydrogenase (LDH and reactive protein C (CRP were determined and blood samples were collected 24 hours before and after each test. The data were analyzed using ANOVA and independent t test. Significance level was considered as P ≤ .05. Results: The use of Aloe vera during aerobic exercise significantly reduced LDH (P = .006 in the supplement group (15% reduction compared to placebo group and CRP with 11% reduction in the supplement group compared to placebo (P = .008. There was no significant reduction in CK. Conclusion: The findings of this study showed that Aloe vera reduces cell damage and inflammation indicators. This result may reflect the role of Aloe vera as anti-inflammatory and antioxidant agent.

Could We Really Use Aloe vera Food Supplements to Treat Diabetes? Quality Control Issues

Directory of Open Access Journals (Sweden)

Solomon Habtemariam

2017-01-01

Full Text Available Diabetes UK has recently listed a number of herbs and spices that have been clinically shown to improve blood glucose control in type-2 diabetes patients and the diabetes high-risk group. With Aloe vera being top in this list, its health benefit along with health and beauty/food retailers supplying it was illustrated in detail. Previous article from this laboratory scrutinised the merit of using A. vera as an alternative therapy to prescription antidiabetic drugs and the risk of using food supplements in the market which do not qualify as drug preparations. In continuation of this discussion, the present study assesses three Aloe Pura brands and one Holland and Barret brand of A. vera juice supplements in the UK market through chromatographic and spectroscopic analysis. While the polysaccharide active ingredient, acemannan, appears to be within the recommended limit, it was found that Aloe Pura (one of the best-selling brands for A. vera supplement products have benzoate additive that does not appear in the supplement levels. Moreover, two of the Aloe Pura brand juices contain methanol, suggesting that the International Aloe Science Council (IASC certification does not guarantee the medicinal quality of these products. The therapeutic fitness of such supplements is discussed.

Could We Really Use Aloe vera Food Supplements to Treat Diabetes? Quality Control Issues

Science.gov (United States)

2017-01-01

Diabetes UK has recently listed a number of herbs and spices that have been clinically shown to improve blood glucose control in type-2 diabetes patients and the diabetes high-risk group. With Aloe vera being top in this list, its health benefit along with health and beauty/food retailers supplying it was illustrated in detail. Previous article from this laboratory scrutinised the merit of using A. vera as an alternative therapy to prescription antidiabetic drugs and the risk of using food supplements in the market which do not qualify as drug preparations. In continuation of this discussion, the present study assesses three Aloe Pura brands and one Holland and Barret brand of A. vera juice supplements in the UK market through chromatographic and spectroscopic analysis. While the polysaccharide active ingredient, acemannan, appears to be within the recommended limit, it was found that Aloe Pura (one of the best-selling brands for A. vera supplement) products have benzoate additive that does not appear in the supplement levels. Moreover, two of the Aloe Pura brand juices contain methanol, suggesting that the International Aloe Science Council (IASC) certification does not guarantee the medicinal quality of these products. The therapeutic fitness of such supplements is discussed. PMID:29511381

Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats.

Science.gov (United States)

Shahraki, Mohammad Reza; Mirshekari, Hamideh; Sabri, Azame

2014-09-01

Aloe vera is a medicinal herb used as an anti-inflammatory and sedative agent. The current study aimed to evaluate the effect of Aloe vera aqueous extract on morphine withdrawal symptoms in morphine-dependent female rats. The current research was performed on 40 female Wista-Albino rats which were made dependent on morphine using Houshyar protocol and were randomly divided into five groups (A, B, C, D, and E). Group A did not receive any agent in the period of handling but other groups (B, C, D and E) received 5, 10, 20 and 40 mg/kg of Aloe vera aqueous extract by gavage, three times daily for a week, respectively. Withdrawal symptoms, stool form, agitation, disparity, floppy eyelids, and body mass variations were checked for 10 days. The obtained data were analyzed using SPSS v.11 software, and Friedman, Kruskal-Wallis, and Mann-Whitney statistical tests. Statistical difference was considered significant (P E were significantly higher than those of others groups; however, these symptoms in group C were significantly lower than those of the other groups. The results of the present study revealed that the Aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats .

Anti-hyperglycemic effect of Aloe vera peel extract on blood sugar level of alloxan-induced Wistar rats

Science.gov (United States)

Peniati, E.; Setiadi, E.; Susanti, R.; Iswari, R. S.

2018-03-01

Aloe vera peel contains flavonoids, alkaloids, tannins, saponins, and sterols as its secondary metabolites. This research explores the effect of Aloe vera peel extract on blood glucose levels of alloxan-induced Wistar rats in a laboratory experimental scale. Blood glucose examination was performed by using GOD-PAP method. Twenty five 2 months old-white rat (Rattus norvegicus) male wistar strain weigh 150-200 grams body weight, and in healthy condition, was randomly divided into five groups. Those five groups were negative control group (K-), positive control group (K+), treatment group 1 (P1), treatment group 2 (P 2), and treatment group 3 (P 3). Each group was fed by standard diet and ad-libitum drinking. Treatments were given for 28 days. On the day 29, blood glucose level of all groups were analyzed. The results showed that the highest blood glucose levels in control group rat were positive (191.2 mg/dl). Aloe vera extract was able to decrease blood sugar level up to 104,6mg/dl in P3 group treatment rats (served Aloe vera extract 350 mg/kg BW/day). It comes to the conclusion that giving Aloe vera peel extract for 28 days decreases blood sugar level of hyperglycemic rat.

Transforming growth factor-β (TGF-β) activation in cutaneous wounds after topical application of aloe vera gel.

Science.gov (United States)

Takzaree, Nasrin; Hadjiakhondi, Abbas; Hassanzadeh, Gholamreza; Rouini, Mohammad Reza; Manayi, Azadeh; Zolbin, Masoumeh Majidi

2016-12-01

Aloe vera is a medicinal plant used to treat various skin diseases. The effects of using aloe vera gel on the healing process were investigated by microscopic methods, cell counting, and TGF-β gene expression in the wound bed. Sixty Wistar rats weighing 200-250 g were placed under anesthesia in sterile conditions. A square 1.5 cm × 1.5 cm wound was made on the back of the neck. The rats were divided into control and 2 experimental groups. Additionally, the control and experimental groups were separated into 3 subgroups corresponding to 4, 7, and 14 days of study. In the first experimental group, aloe vera was used twice on the wound. The second experimental group received aloe vera overtreatment once on the wound. The positive control group received daily application of 1% phenytoein cream following surgical wound creation. The control group did not receive any treatment. This tissue was examined using histological staining (H&E) and Masson's Trichrome. Wound surface and wound healing were evaluated separately. TGF-β gene expression was analyzed by RT-PCR. Results showed that fibroblasts in both experimental groups were significantly increased, thereby acceleration wound healing. Application of aloe vera gel will increase TGF-β gene expression, ultimately accelerating the wound healing process.

Comparative Efficacy of Aloe vera and Benzydamine Mouthwashes on Radiation-induced Oral Mucositis: A Triple-blind, Randomised, Controlled Clinical Trial.

Science.gov (United States)

Sahebjamee, Mahnaz; Mansourian, Arash; Hajimirzamohammad, Mohammad; Mohammad, Haji Mirza Mohammad; Zadeh, Mohsen Taghi; Bekhradi, Reza; Kazemian, Ali; Manifar, Soheila; Ashnagar, Sajjad; Doroudgar, Kiavash

2015-01-01

To compare the efficacy of an Aloe vera mouthwash with a benzydamine mouthwash in the alleviation of radiation- induced mucositis in head and neck cancer patients using a triple-blind, randomised controlled trial. Twenty-six eligible head and neck cancer patients who were to receive conventional radiation therapy at the radiation oncology department were randomised to receive an Aloe vera mouthwash or a benzydamine mouthwash. Mucositis severity was assessed during the course of radiation therapy using the WHO grading system. At baseline, there was no difference in the distribution of mucositis severity between the two groups. The mean interval between radiation therapy and onset of mucositis was similar for both groups (Aloe vera 15.69±7.77 days, benzydamine 15.85±12.96 days). The mean interval between the start of radiation therapy and the maximum severity of mucositis were was also similar in both the Aloe vera and benzydamine groups (Aloe vera 23.38±10.75 days, benzydamine 23.54±15.45 days). Mean changes of mucositis severity over time in both groups were statistically similar and the effect of both treatments did not change signficantly with time (p=0.09). Aloe vera mouthwash was as beneficial as benzydamine mouthwash in alleviating the severity of radiation-induced mucositis and showed no side effects. The Aloe vera mouthwash could be an alternative agent in the treatment of radiation-induced mucositis in patients with head and neck cancers.

Effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis.

Science.gov (United States)

Suksomboon, N; Poolsup, N; Punthanitisarn, S

2016-04-01

Aloe vera (Aloe vera (L.) Burm.f., Xanthorrhoeaceae family) has long been used in folk or traditional medicine for diabetes. Several studies have been conducted on the effect of Aloe vera on glycaemic control, but the results appear inconsistent. We undertook a systematic review and meta-analysis to assess the effect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes. A comprehensive literature search was conducted through MEDLINE, CENTRAL, CINAHL, Scopus, http://clinicaltrials.gov, Web of Science, Proquest, LILACS, HerbMed, NAPRALERT and CNKI to the end of January 2016 without language restriction. Historical search of relevant articles and personal contact with experts in the area were also undertaken. Studies were included if they were (1) randomized controlled trials of Aloe vera aimed at assessing glycaemic control in prediabetes or type 2 diabetes and (2) reporting fasting plasma glucose (FPG) or haemoglobin A1c (HbA1c ). Treatment effect was estimated with mean difference in the final value of FPG and HbA1c between the treatment and the control groups. Eight trials involving 470 patients (235 each for prediabetes and type 2 diabetes) were included. In prediabetes, Aloe vera significantly improved FPG (mean difference -0·22 mmol/L, 95% CI -0·32 mmol/L to -0·12 mmol/L, P Aloe vera may improve glycaemic control in type 2 diabetes, with a marginal improvement in FPG (mean differences -1·17 mmol/L, 95% CI -2·35 mmol/L to 0·00 mmol/L, P = 0·05) and a significant improvement in HbA1c (mean difference -11 mmol/mol, 95% CI -19 mmol/mol to -2 mmol/mol, P = 0·01). The current evidence suggests some potential benefit of Aloe vera in improving glycaemic control in prediabetes and type 2 diabetes. However, given the limitations of the available evidence and the high heterogeneity in study results, high-quality, well-powered randomized controlled trials using standardized preparations are needed to quantify any beneficial effects of Aloe vera on

β-Thalassemia and Polycythemia vera : Targeting chronic stress erythropoiesis

NARCIS (Netherlands)

Crielaard, Bart J; Rivella, Stefano

β-Thalassemia and Polycythemia vera are genetic disorders which affect the synthesis of red blood cells, also referred to as erythropoiesis. Although essentially different in clinical presentation - patients with β-thalassemia have an impairment in β-globin synthesis leading to defective

Effect of Gamma Irradiation and Aloe vera on Antioxidant Status and Thyroid Functions in Female Rats

International Nuclear Information System (INIS)

El-Sherbiny, E. M.

2008-01-01

The aim of this research is to evaluate the antioxidant status and thyroid functions of female albino rats (Rattus norvegicus) when exposed to 3.0 Gy of gamma ray (dose rats = 0.696 Gy/min.) as s single dose and the role of 0.25 ml Aloe vera whole leaf juice filtrate/kg body weight against the damage caused by gamma irradiation. Total number of 50 female albino rats were equally divided into 5 groups; normal control group, irradiated group, Aloe vera administered group, irradiated rats followed by Aloe vera administration for 1 week and the 5th group is the irradiated rats followed by Aloe vera administration for 2 weeks starting from 24 h post-irradiation. Total antioxidant capacity, thiobarbituric acid reactive substances (TBARs), triiodothyronine (T3) and thyroxine (T4) were measured in serum of all groups. The results of this study revealed that 3.0 Gy of gamma irradiation resulted in a highly significant reduction in serum total antioxidant capacity (39.89%), highly significant increase in TBARs (29.19%) and a significant increase in serum T3 and T4 levels (8.21 and 25.51%, respectively) compared to control group. There was a non-significant change in serum total anti-oxidant capacity and TBARs, and a highly significant decrease in serum T3 and T4 levels (31.00 and 36.57%) in rats administered Aloe vera alone. Concerning rats administered Aloe vera whole leaf juice filtrate post-irradiation, serum total anti-oxidant capacity and TBARs were restored to the normal levels after 2 weeks. Serum levels of T3 and T4 (represent thyroid functions) were restored to the normal levels after 1 week and found to be inhibited (20.41 and 22.62%, respectively) after 2 weeks of administration. (author)

Kriegs- und Generationszeugen: Adrienne Thomas und Vera Brittain // Generation and War Witnesses: Adrienne Thomas and Vera Brittain

OpenAIRE

Zitzlsperger, Ulrike

2016-01-01

Im Vordergrund stehen in diesem Beitrag Autorinnen, die sich in den dreißiger Jahren kritisch mit dem Ersten Weltkrieg und seinen Folgen auseinandersetzten. Am Beispiel von Adrienne Thomas ("Die Katrin wird Soldat") und Vera Brittain ("Testament of Youth") soll untersucht werden, wie die erklärte Zugehörigkeit von Frauen zur 'Lost Generation' mit der aktiven Kriegsteilnahme als Krankenschwester und einem differenzierten Patriotismusverständnis verbunden wurde. Auffallend sind dabei nicht nur ...

Effectiveness of Aloe Vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns.

Science.gov (United States)

Shahzad, Muhammad Naveed; Ahmed, Naheed

2013-02-01

To assess the efficacy of Aloe Vera gel compared with 1% silver sulfadiazine cream as a burn dressing for the treatment of superficial and partial thickness burns. This Interventional Comparative study was carried out at the Burn unit and Plastic surgery department, Nishtar Hospital Multan, Pakistan from July 2008 to December 2010. A total of 50 patients with superficial and partial thickness burns were divided into two equal groups randomly by consecutive sampling method, one group was dressed with Aloe Vera gel while the other was treated with 1% silversulphadiazine cream, and the results regarding duration of wound epithelialization, pain relief and cost of treatment were compared. In patients treated with Aloe Vera gel, healing of burn wounds were remarkably early than those patients treated with 1% silver sulfadiazine. All the patients of Aloe Vera group were relieved of pain earlier than those patients who were treated with SSD. Thermal burns patients dressed with Aloe Vera gel showed advantage compared to those dressed with SSD regarding early wound epithelialization, earlier pain relief and cost-effectiveness.

An in vivo and in vitro investigation of the effect of Aloe vera gel ethanolic extract using animal model with diabetic foot ulcer

Directory of Open Access Journals (Sweden)

Mohan Daburkar

2014-01-01

Full Text Available Aim: To examine the preventive effect of Aloe vera gel ethanolic extract using diabetic foot ulcer (DFUs protocol in Wistar rats. Materials and Methods: Male Wistar rats were divided into untreated control (Group I, untreated DFUs (Group II, DFUs treated with A. vera gel ethanolic extract (Group III, DFUs treated with topical A. vera gel (Group IV, DFUs treated with A. vera gel ethanolic extract and topical A. vera gel (Group V. The rats in the treatment groups were daily administered the A. vera gel and ethanolic extract for 9 days. Fasting blood glucose levels and percentage of wound ulcer contraction were measured on day 3, 6, and 9. Statistical Analysis used: The results are expressed as a mean ± Standard Error Mean (SEM. Data were analyzed using one-way analysis of variance (ANOVA after Newman-Keuls test. P < 0.05 were considered statistically significant in all cases. Results: Oral administration of A. vera gel ethanolic extract at a dose of 300 mg/kg body weight per day to diabetic rats for a period of 9 days resulted in a significant reduction in fasting blood glucose and a significant improvement in plasma insulin. Topical application of A. vera gel at a dose 30 mg/kg body weight per day to streptozotocin (STZ-induced diabetic rats for a period of 9 days resulted in no change in blood glucose and plasma insulin. Oral administration as well as topical application of A. vera gel ethanolic extract and gel significantly reduced the blood glucose, improved the plasma insulin, and significantly increased DNA and glycosaminoglycans (GAGs to improve the wound ulcer healing as well as the breaking strength on day 9. Conclusions: Present findings provide a scientific rationale for the use of A. vera gel ethanolic extract, and showed that the gel attenuated the diabetic foot wound in rats.

Karyological studies in ten different populations of desert lily aloe vera from pakistan

International Nuclear Information System (INIS)

Jahan, B.; Vahidy, A.A.

2014-01-01

To enhance theoretical basis of Aloe feeding and provide cytological basement, the karyotype and morphology of mitotic chromosomes, ten different populations of Aloe vera collected from various geographical locations of Karachi, Pakistan were studied by aceto-orcein staining technique. The results showed that chromosome number of Aloe vera is 2n=14. The karyotype is bimodal and consists of 14 chromosomes (8 large and 6 small) predominantly with submedian, median and subterminal centromere. Average chromosome lengths among populations ranged from 7.95-2.36 micro m. (author)

Process Optimization of Pontianak Aloe vera Powder (Aloe chinensis Beakker as Raw Material for Hand body lotion

Directory of Open Access Journals (Sweden)

Nana Supriyatna

2010-12-01

Full Text Available Process optimization of Pontianak aloe vera powder (Aloe chinensis Beaker  as raw material for hand body lotion have been conducted on laboratory scale with the aim of obtaining the optimum conditions of processing technologies through the addition of maltodextrin and Carboxy Methyl Cellulase. The optimum results achieved at the ratio of maltodextrin to the CMC by 90%: 10%. Characteristics of aloe vera powder produced showing yellowish white color, water content of 8:56%, 5:50 pH, total solid Aloe 25.5%, weight flour ratio and fresh aloe vera leaves 1.5: 100, aloin content of 164.40 ppm, 257.08 ppm malic acid content, 10.32 ppm vitamin E and 1.4 x 105 colonies/g total bacteria. Making hand body lotion of aloe vera powder optimization results show the characteristic white color with a fragrant aroma, acidity (pH 7:07, 10.34 ppm of malic acid, 1.1 x 104 colony/g total bacteria, and quite stable while storage.

The JAK2 V617F allele burden in essential thrombocythemia, polycythemia vera and primary myelofibrosis

DEFF Research Database (Denmark)

Larsen, Thomas Stauffer; Pallisgaard, Niels; Møller, Michael Boe

2007-01-01

BACKGROUND AND OBJECTIVES: The JAK2 V617F tyrosine kinase mutation is present in the great majority of patients with polycythemia vera (PV), and approximately half of the patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The three distinct disease entities may be consi......BACKGROUND AND OBJECTIVES: The JAK2 V617F tyrosine kinase mutation is present in the great majority of patients with polycythemia vera (PV), and approximately half of the patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). The three distinct disease entities may...... = 0.03), CD34 counts (P = 0.03), lactate dehydrogenase and Polycythemia Rubra Vera gene 1 levels (P = 0.03 and P

JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

Science.gov (United States)

Scott, Linda M.; Tong, Wei; Levine, Ross L.; Scott, Mike A.; Beer, Philip A.; Stratton, Michael R.; Futreal, P. Andrew; Erber, Wendy N.; McMullin, Mary Frances; Harrison, Claire N.; Warren, Alan J.; Gilliland, D. Gary; Lodish, Harvey F.; Green, Anthony R.

2010-01-01

BACKGROUND The V617F mutation, which causes the substitution of phenylalanine for valine at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. However, the molecular basis of these myeloproliferative disorders in patients without the V617F mutation is unclear. METHODS We searched for new mutations in members of the JAK and signal transducer and activator of transcription (STAT) gene families in patients with V617F-negative polycythemia vera or idiopathic erythrocytosis. The mutations were characterized biochemically and in a murine model of bone marrow transplantation. RESULTS We identified four somatic gain-of-function mutations affecting JAK2 exon 12 in 10 V617F-negative patients. Those with a JAK2 exon 12 mutation presented with an isolated erythrocytosis and distinctive bone marrow morphology, and several also had reduced serum erythropoietin levels. Erythroid colonies could be grown from their blood samples in the absence of exogenous erythropoietin. All such erythroid colonies were heterozygous for the mutation, whereas colonies homozygous for the mutation occur in most patients with V617F-positive polycythemia vera. BaF3 cells expressing the murine erythropoietin receptor and also carrying exon 12 mutations could proliferate without added interleukin-3. They also exhibited increased phosphorylation of JAK2 and extracellular regulated kinase 1 and 2, as compared with cells transduced by wild-type JAK2 or V617F JAK2. Three of the exon 12 mutations included a substitution of leucine for lysine at position 539 of JAK2. This mutation resulted in a myeloproliferative phenotype, including erythrocytosis, in a murine model of retroviral bone marrow transplantation. CONCLUSIONS JAK2 exon 12 mutations define a distinctive myeloproliferative syndrome that affects patients who currently receive a diagnosis of polycythemia vera or idiopathic erythrocytosis

Lenguas en contacto en Vera de Bidasoa

Directory of Open Access Journals (Sweden)

García Mouton, Pilar

1996-06-01

Full Text Available By the use of maps from the Linguistic and Ethnographic Atlas of Aragón, Navarra, and Rioja (ALEANR, as well as Julio Caro Baroja's writings, the article discusses the coexistence of Basque and Castilian in Vera de Bidasoa, which is reflected in the presence of loanwords and translation loanwords from one language to the other. In addition, the article deals with the degree of stability of semantic fields: which ones tend to be more receptive, and which ones more averse, to borrowings from the second language.A través de los mapas del ALEANR (Atlas Lingüístico y Etnográfico de Aragón, Navarra y RiojaVera de Bidasoa. Esta situación se refleja en la presencia de préstamos y calcos entre las dos lenguas. También se estudia qué campos léxicos son más propensos a conservar el léxico patrimonial y cuáles más receptivos a la segunda lengua.

Menurunkan Derajat Flebitis Akibat Terapi Intravena pada Anak dengan Kompres Aloe Vera: Studi Pilot

OpenAIRE

Hasanah, Oswati; Novayelinda, Riri; Maifera, Maifera; Isdelni, Isdelni

2017-01-01

Reducing the Grade of Phlebitis due to Intravenous Therapy in Children with Aloe Vera Compress. Intravenous therapy is a type of treatment that is widely provided to hospitalized children. Intravenous application in a long time causes complications in children, such as phlebitis. One of the interventions in handling phlebitis is compressing Aloe vera which is useful because it has electrolyte in low concentration so as not to cause extravasation. This study aims to identify the effect of Aloe...

Lack of Prophylactic Effects of Aloe Vera Gel on Radiation Induced Dermatitis in Breast Cancer Patients

Science.gov (United States)

Ahmadloo, Niloofar; Kadkhodaei, Behnam; Omidvari, Shapour; Mosalaei, Ahmad; Ansari, Mansour; Nasrollahi, Hamid; Hamedi, Sayed Hasan; Mohammadianpanah, Mohammad

2017-04-01

Purpose: Radiotherapy induced dermatitis is a common and sometimes serious side effect. We conducted a randomized study to understand whether the adjunctive use of aloe vera gel might reduce the prevalence and/or severity of radiotherapy induced dermatitis. Methods: One hundred patients with newly diagnosed breast cancer were randomized to receive aloe vera gel or nothing during adjuvant radiotherapy consisting of conventional external beam radiation using 6 MV mega voltage linear accelerator photons. The radiation portals were composed of breast fields in all patients and supraclavicular and posterior axillary fields in node positive cases. The total dose was 50 Gy with a daily fraction of 2 Gy, five fractions per week. Results: Dermatitis was first found among patients of both groups after week 2. In the aloe vera and control groups, 2/8 patients and 5/12 patients had dermatitis grade 1 after weeks 2 (P value = 0.240) and 3 (P value = 0.317). After the 4th week, the numbers were 18 and, 23 fordermatitis grade 1 and only 1 for grade 3 dermatitis (P value = 0.328). After the 5th week, 31, 12 and 2 patients in the aloe vera group and 36, 6 and 5 of the controls had grades 1, 2 and 3 dermatitis, respectively (P value = 0.488). Conclusion: Aloe vera exerted no positive effect on prevalence orseverity of radiation dermatitis in this study. Creative Commons Attribution License

Effectiveness of Aloe Vera and Antioxidant along with Physiotherapy in the Management of Oral Submucous Fibrosis.

Science.gov (United States)

Singh, Nisha; Hebbale, Manjula; Mhapuskar, Amit; Ul Nisa, Shams; Thopte, Shameeka; Singh, Saumya

2016-01-01

Oral submucous fibrosis (OSMF) is a well-established precancerous condition affecting the oral mucosa. It is a disease that causes significant morbidity (in terms of loss of mouth function as tissues become rigid and mouth opening becomes difficult) and mortality (when transformation into squamous cell carcinoma occurs). The aim of the study is to compare the efficacy of Aloe vera with antioxidant when given along with physiotherapy in the management of OSMF. Forty patients presenting with clinical signs and symptoms of OSMF were included for the study after informed consent. Group A included 20 patients who received Aloe vera gel (forever living gel) along with physiotherapy. Group B included 20 patients who received antioxidant capsules twice daily for 3 months along with physiotherapy exercises four times in a day. The following parameters, that is, burning sensation, mouth opening, tongue protrusion and cheek flexibility were recorded at each visit. Majority of the participant enrolled were in the age range of 30 to 35 years. Improvement in all the parameters was seen with the individuals receiving Aloe vera gel in comparison to antioxidants. So, Aloe vera being a soothing, simple and safe mode of treatment along with proper habit restriction can be considered to be an effectual protocol in the management of OSMF. The analgesic effects of Aloe vera with the physiotherapy exercises provide better results in reducing burning sensation and improving mouth opening, tongue protrusion and cheek flexibility in comparison to antioxidants.

Aloe vera: A review of toxicity and adverse clinical effects.

Science.gov (United States)

Guo, Xiaoqing; Mei, Nan

2016-04-02

The Aloe plant is employed as a dietary supplement in a variety of foods and as an ingredient in cosmetic products. The widespread human exposure and its potential toxic and carcinogenic activities raise safety concerns. Chemical analysis reveals that the Aloe plant contains various polysaccharides and phenolic chemicals, notably anthraquinones. Ingestion of Aloe preparations is associated with diarrhea, hypokalemia, pseudomelanosis coli, kidney failure, as well as phototoxicity and hypersensitive reactions. Recently, Aloe vera whole leaf extract showed clear evidence of carcinogenic activity in rats, and was classified by the International Agency for Research on Cancer as a possible human carcinogen (Group 2B). This review presents updated information on the toxicological effects, including the cytotoxicity, genotoxicity, carcinogenicity, and adverse clinical effects of Aloe vera whole leaf extract, gel, and latex.

Comparative antimicrobial activities of aloe vera gel and leaf ...

African Journals Online (AJOL)

The comparative antimicrobial activities of the gel and leaf of Aloe vera were tested against Staphylococcus aureus, Pseudomonas aeruginosa, Trichophyton mentagraphytes, T. schoeleinii, Microsporium canis and Candida albicans. Ethanol was used for the extraction of the leaf after obtaining the gel from it. Antimicrobial ...

Van gen naar ziekte; JAK2 en polycythaemia vera

NARCIS (Netherlands)

Koene, H. R.; Biemond, B. J.; van der Schoot, C. E.

2007-01-01

The identification of a point mutation in the JAK2 gene in most patients with polycythaemia vera (PV) has led to increased insight into the pathogenesis of the disease. The mutation causes cytokine-independent growth and proliferation of haematopoietic precursor cells, leading to erythrocytosis. The

Observations on transition of polycythaemia vera into acute or chronic granulocytic leukaemia during treatment with radioactive phosphorus 32P

International Nuclear Information System (INIS)

Krasnik, W.

1975-01-01

In a group of 172 cases of polycythaemia vera treated with radioactive phosphorus 32 P acute granulocytic leukaemia developed in 3 cases and chronic granulocytic leukaemia in 6 cases. Development of acute granulocytic leukaemia during treatment with radioactive phosphorus for polycythaemia vera may be considered with some probability as a result of leukaemia-inducing action of ionizing radiation. Transition of polycythaemia vera into chronic granulocytic leukaemia seems to a natural outcome of this complex myeloproliferative syndrome in patients with survival prolonged by treatment with 32 P. (author)

TBT recommends : Vera Bila. The No Smoking Orchestra. Robert Plant

Index Scriptorium Estoniae

2005-01-01

Mustlasansambli Kale ja Vera Bila kontserdist 8. apr Tallinnas. Bosnia filmirežissööri Emir Kusturica ja tema ansambli No Smoking Orchestra kontserdist 12. apr. Riias. Inglise rocklaulja Robert Planti kontserdist 10. apr. Vilniuses

Aloe vera extract as a promising treatment for the quality maintenance of minimally-processed table grapes

Directory of Open Access Journals (Sweden)

Giuseppina Rosaria Antonella Alberio

2015-06-01

Full Text Available The effect of an edible film obtained from a commercial Aloe vera extract, on the quality maintenance of minimally processed grapes belonging to three different cultivars (Sugar One, Victoria and Black Magic was evaluated by enzymatic (PPO, PME, β-GAL, physicochemical (pH, acidity, °Brix, and sensorial methods. All the analyzed parameters were measured in extracts obtained from minimally processed grapes packaged in ordinary atmosphere and stored at 4 °C for 15 days. Samples dipped into Aloe vera showed significant differences (p≤0.05 compared to untreated ones. The determination of such parameters and the evaluation of consumer acceptability were helpful to determine the effectiveness of the post-harvest treatment with Aloe vera for a storage period of 15 days.

Enhanced biocompatibility of ZnS:Mn quantum dots encapsulated with Aloe vera extract for therapeutic applications

International Nuclear Information System (INIS)

Anilkumar, M; Sneha Saj, A; Bindu, K R; Anila, E I

2016-01-01

Toxicity of nanoparticles remains to be a major issue in their application to the biomedical field. Aloe vera (AV) is one of the most widely exploited medicinal plants that have a multitude of amazing properties in the field of medicine. Methanol extract of Aloe vera can be used as a novel stabilising agent for quantum dots to reduce toxicity. We report the synthesis, structural characterization, antibacterial activity and cytotoxicity studies of ZnS:Mn quantum dots synthesized by the colloidal precipitation method, using methanol extract of Aloe vera (AVME) as the capping agent. The ZnS:Mn quantum dots capped with AVME exhibit superior performances in biocompatibility and antibacterial activity compared with ZnS:Mn quantum dots without encapsulation. (paper)

Clinical Effectiveness of Aloe Vera in the Management of Oral Mucosal Diseases- A Systematic Review

Science.gov (United States)

Nair, Gopakumar Ramachandran; Naidu, Giridhar Seetharam; Jain, Supreet; Makkad, Ramanpal Singh; Jha, Abhishek

2016-01-01

Introduction Aloe vera is well known for its medicinal properties which lead to its application in treating various diseases. Its use in treating oral lesions has not been much documented in literature. Aim Although, systematic reviews on aloe vera and its extracts have been done earlier, but in relation to oral diseases this is the first systematic review. The aim of the present systematic review was to compile evidence based studies on the effectiveness of Aloe vera in treatment of various oral diseases. Materials and Methods Computerized literature searches were performed to identify all published articles in the subject. The following databases were used: PUBMED [MEDLINE], SCOPUS, COCHRANE DATABASE, EMBASE and SCIENCE DIRECT using specific keywords. The search was limited to articles published in English or with an English Abstract. All articles (or abstracts if available as abstracts) were read in full. Data were extracted in a predefined fashion. Assessment was done using Jadad score. Results Fifteen studies satisfied the inclusion criteria. Population of sample study ranged from 20 patients to 110 patients with clinically diagnosed oral mucosal lesions. Out of 15 studies, five were on patients with oral lichen planus, two on patients with oral submucous fibrosis, other studies were carried on patients with burning mouth syndrome, radiation induced mucositis, candida associated denture stomatitis, xerostomic patients and four were on minor recurrent apthous stomatitis. Most studies showed statistically significant result demonstrating the effectiveness of Aloe vera in treatment of oral diseases. Conclusion Although there are promising results but in future, more controlled clinical trials are required to prove the effectiveness of Aloe vera for management of oral diseases. PMID:27656587

The Protective Effect of Aloe Vera on Histological Structure of Endocrine Portion of Pancreas Gland in the Diabetic Rat

Directory of Open Access Journals (Sweden)

N Erfani-Majd

2016-01-01

Full Text Available Introduction: Since aloe vera plant has many medical benefits, the present study aimed to investigate the protective effects of Aloe vera gel on the pancreatic islets and beta cells. Methods: This experimental study consisted of 50 mature male rats aged 2-3 months and weighed 200-250 g, who were randomly divided into five groups (n=10. Group I (control did not receive any treatments, and group II were diabetized via Streptozotocin (IP in 65 mg/kg, whose blood sample was taken after one week. Rats with blood glucose more than 250 mg/dL were considered as diabetic. Group III diabetic rats received the Aloe vera gel daily with dosage of 400 mg/kg, and group IV diabetic rats received insulin in 10 units/rat. Group V involved healthy rats which received only Aloe vera gel. After the last Aloe vera gel administration, blood glucose and body weight of all groups were measured on 15th and 30th days. Animals were euthanized with ether. Then tissues samples were collected from pancreas gland and fixed in 10% neutral buffered formalin solution. The 5-6 µ sections were made by paraffin embedding method and stained using haematoxylin-eosin (H&E and Aldehyde fuchsin stains. Ultimately, the histomorphometrical parameters were evaluated. Results: The mean number and size of pancreatic islets and beta cells of Langerhans islets decreased significantly in the diabetic group compared to the control group. The number of beta cells and diameter of langerhans islets increased significantly in the rats treated by Aloe vera gel in comparison to diabetic group at the end of 15th and 30th days. Conclusion: Applying Aloe vera gel seems to improve the renewal and restoration of langerhans islets and beta cells of pancreas gland in the diabetic rat.

Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Science.gov (United States)

Radha, Maharjan H.; Laxmipriya, Nampoothiri P.

2014-01-01

Aloe vera (蘆薈 lú huì) is well known for its considerable medicinal properties. This plant is one of the richest natural sources of health for human beings coming. The chemistry of the plant has revealed the presence of more than 200 different biologically active substances. Many biological properties associated with Aloe species are contributed by inner gel of the leaves. Most research has been centralized on the biological activities of the various species of Aloe, which include antibacterial and antimicrobial activities of the nonvolatile constituents of the leaf gel. Aloe species are widely distributed in the African and the eastern European continents, and are spread almost throughout the world. The genus Aloe has more than 400 species but few, such as A. vera, Aloe ferox, and Aloe arborescens, are globally used for trade. A. vera has various medicinal properties such as antitumor, antiarthritic, antirheumatoid, anticancer, and antidiabetic properties. In addition, A. vera has also been promoted for constipation, gastrointestinal disorders, and for immune system deficiencies. However, not much convincing information is available on properties of the gel. The present review focuses on the detailed composition of Aloe gel, its various phytocomponents having various biological properties that help to improve health and prevent disease conditions. PMID:26151005

Evolutionary history and leaf succulence as explanations for medicinal use in aloes and the global popularity of Aloe vera

DEFF Research Database (Denmark)

Grace, Olwen Megan; Buerki, Sven; Symonds, Matthew RE

2015-01-01

Background: Aloe vera supports a substantial global trade yet its wild origins, and explanations for its popularity over 500 related Aloe species in one of the world’s largest succulent groups, have remained uncertain. We developed an explicit phylogenetic framework to explore links between...... the rich traditions of medicinal use and leaf succulence in aloes. Results: The phylogenetic hypothesis clarifies the origins of Aloe vera to the Arabian Peninsula at the northernmost limits of the range for aloes. The genus Aloe originated in southern Africa ~16 million years ago and underwent two major...... succulence among aloes has yielded new explanations for the extraordinary market dominance of Aloe vera. The industry preference for Aloe vera appears to be due to its proximity to important historic trade routes, and early introduction to trade and cultivation. Well-developed succulent leaf mesophyll tissue...

Aloe vera is non-toxic to cells: A microculture tetrazolium technique colorimetric assay study

Directory of Open Access Journals (Sweden)

Devi Gopakumar

2014-01-01

Full Text Available Introduction: Aloe vera (Av, a succulent of Liliaceae family is now a widely used medicinal plant. Its′ application covers a wide spectrum of human diseases, including oral mucosa, gastric mucosa and skin. Aloe vera preparations in the form of gel, mouth washes and cream are applied topically for many oral diseases. The applications include oral lichen planus, candidiasis, oral submucous fibrosis, geographic tongue, etc. Aims and Objectives: To evaluate the cytotoxicity of Av on human fibroblasts. Materials and Methods: Aloe vera preparation (70% was applied on the fibroblast cell lineage and the cell viability was evaluated by microculture tetrazolium technique (MTT colorimetric assay. Results: The cell viability at different concentrations was measured. The cells have maintained their viability at different concentrations used in the study. Conclusion: Our study shows the cell viability at different sample concentrations of Av. This could open up wide clinical applications of Av for reactive, inflammatory and potentially malignant oral and other mucocutaneous diseases.

Memristors in the electrical network of Aloe vera L.

Science.gov (United States)

Volkov, Alexander G; Reedus, Jada; Mitchell, Colee M; Tucket, Clayton; Forde-Tuckett, Victoria; Volkova, Maya I; Markin, Vladislav S; Chua, Leon

2014-01-01

A memristor is a resistor with memory, which is a non-linear passive two-terminal electrical element relating magnetic flux linkage and electrical charge. Here we found that memristors exist in vivo. The electrostimulation of the Aloe vera by bipolar sinusoidal or triangle periodic waves induce electrical responses with fingerprints of memristors. Uncouplers carbonylcyanide-3-chlorophenylhydrazone and carbonylcyanide-4-trifluoromethoxy-phenyl hydrazone decrease the amplitude of electrical responses at low and high frequencies of bipolar periodic sinusoidal or triangle electrostimulating waves. Memristive behavior of an electrical network in the Aloe vera is linked to the properties of voltage gated ion channels: the K+ channel blocker TEACl reduces the electric response to a conventional resistor. Our results demonstrate that a voltage gated K+ channel in the excitable tissue of plants has properties of a memristor. The discovery of memristors in plants creates a new direction in the modeling and understanding of electrical phenomena in plants. PMID:25763487

Propriedades farmacológicas da Aloe vera (L. Burm. f.

Directory of Open Access Journals (Sweden)

V.S. Freitas

2014-06-01

Full Text Available A Aloe vera (L. Burm.f. tem sido utilizada há milhares de anos na medicina tradicional para o tratamento de diversos males. O intuito desse trabalho foi o levantamento bibliográfico de artigos que evidenciassem a atividade farmacológica da Aloe vera. A revisão contemplou livros e periódicos nacionais e internacionais indexados nas bases de dados MEDLINE, LILACS e SciElo, nos idiomas português, inglês e espanhol, utilizando as palavras-chave citadas. Após o levantamento bibliográfico, constatou-se que várias atividades biológicas são atribuídas a Aloe vera. Evidências sugerem eficácia no tratamento da psoríase, herpes genital, queimaduras e hiperglicemia. Além disto, também foram demonstradas atividades antineoplásica, antimicrobiana, anti-inflamatória e imunomodulatória por estudos in vitro e in vivo, entretanto, na cicatrização de feridas, os resultados foram conflitantes. No tratamento de dermatite por radiação e em queimaduras solares sua eficácia não foi comprovada e foram relatados casos de hepatite aguda devido ao consumo de preparações orais. Tendo em vista as várias atividades comprovadas e poucos relatos acerca de sua contra indicação, conclui-se que o uso desta espécie corrobora o vasto uso popular.

Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

Directory of Open Access Journals (Sweden)

Hairong Wang

2017-10-01

Full Text Available Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE incorporated with nano-hydroxyapaptite nanorods (mPE-nHA was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR, scanning electron microscope (SEM, atomic force microscopy (AFM and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

Radionuclide investigation of the bone marrow with 99mTc-coren in patients with polycythemia vera

International Nuclear Information System (INIS)

Vasil'ev, L.Ya.; Prikhod'ko, A.G.; Rozdil'skij, S.I.; Astap'eva, O.N.; Grusha, A.V.

1990-01-01

The results of radionuclide investigation of the bone marrow in 44 patients (of them 32 with polycythemia vera) were presented. The informative value of bone marrow scintigraphy and whole-body radiometry using 99m Tc-coren was shown in the patients with polycythemia vera at advanced stages. The results obtained made it possible to specify a clinical stage and prognosis of disease, and to optimize therapy

Prevention of radiation and cadmium induced haematological alternations in the Swiss albino mice by Aloe Vera

International Nuclear Information System (INIS)

Agarwal, Manisha; Songara, Venkteshwar; Singariya, Seema; Meena, Dinesh; Chakrawarti, Aruna; Purohit, R.K.

2013-01-01

The development of effective radio protectors and radio recovery drugs is of great importance in view of their potential application during both planned (i.e., radiotherapy) and unplanned radiation exposure (i.e., in the nuclear industry and natural background radiation). The combined effect of radiation and cadmium further increases the causation of damages to organs and tissues. Aloe vera has enjoyed a reputation as a healer for millennia, based primarily on anecdotal evidence. For the last 40 years concerted efforts by the scientific research community has brought Aloe vera out of the realm of folk medicine, providing it solid medical and scientific foundation. Haematopoietic organs are among the most radiosensitive cells in the living organisms. Therefore, present study was carried out to study the modulatory influence of Aloe vera against radiation and cadmium induced hematological changes in the Swiss albino mice. For the study, six to eight weeks old male Swiss albino mice were procured and kept in polypropylene cages.The animals were exposed 3.5 Gy and 7.0 Gy of gamma radiation with or without cadmium chloride treatment. The Aloe vera was administered seven days prior to irradiation or cadmium chloride treatment. Five animals from each group were autopsied by cervical dislocation at each post treatment interval of 1, 2, 4, 7, 14 and 28 days. Blood was collected in heparinized tubes to estimate various haematological parameters viz. RBC, WBC, PCV, Haemoglobin and MCV. Radiation exposure resulted in a significant decline in RBC, WBC, PCV, Haemoglobin and MCV up to day-14 in peripheral blood, thereafter it increased up to day-28 without reaching to normal. After combined treatment of radiation and cadmium chloride the more severe changes were noticed showing synergistic or additive effect. An early and fast recovery was seen in Aloe vera pretreatment groups. Thus, it may be concluded from above observation that Aloe vera has the potential of combating the

Revisión de la aloe vera (Barbadensis Miller en la dermatología actual Revision Of Aloe Vera (Barbadensis Miller In Actual Dermatology

Directory of Open Access Journals (Sweden)

GM Ferraro

2009-12-01

Full Text Available El Aloe vera es una planta de uso popular en el tratamiento de algunas enfermedades de la piel y de aplicación frecuente en la cosmetología. Forma parte de diversas cremas o geles, siendo usado como antiinflamatorio y reconstituyente del tejido epitelial. Aunque se conocen varios mecanismos de acción e indicaciones clínicas, se debe realizar una revisión de las mismas para su uso, avalados por ensayos controlados para determinar su eficacia real.The Aloe vera is a popular plant used in the treatment of certain skin diseases that has a frequent application in cosmetology. It forms a part of diverse creams or gels, being used as anti-inflammatory and restorative of epithelial tissue. Although there are several mechanisms of action and clinical indications, a review of its use should be done supported by controlled trials to determine its effectiveness.

Study on genetic diversity of some Iranian Pistachio (Pistacia vera L ...

African Journals Online (AJOL)

hope&shola

2010-11-08

Nov 8, 2010 ... Keywords: Pistacia vera, genetic diversity, clustering, population parameters. .... used to detect DNA polymorphism and genetic diversity in ..... Project on Underutilized ... 2nd. nat. symp. of cellular and molecular biology.

Protective efficacy of Aloe vera against radiation and cadmium induced haematological changes in the Swiss Albino mice

International Nuclear Information System (INIS)

Agarwal, Manisha; Purohit, R.K.; Chakrawarti, Aruna; Basu, Arindam; Bhartiya, K.M.

2011-01-01

The aim of the present study was to evaluate the protective effect of Aloe vera against radiation and cadmium induced haematological changes in the Swiss albino mice; 6-8 weeks old animals from each of the experimental groups were sacrificed by cervical dislocation at each post treatment intervals of 1,2,4,7,14 and 28 day. After sacrificing the animals, the blood was collected by cardiac puncture in heparinized tubes for various haematological studies. The values of RBC, WBC, Haemoglobin and PCV were found to decrease up to day-14 in non drug treated groups (II,III and IV), thereafter they increased on day-28. Whereas the values decreased upto day-7 in Aloe vera treated groups (V,VI,VlI) thereafter increased tip to day-28. On the other hand, the value of MCV increased upto day- 14 in non-drug treated groups (II, III, IV) and tip to day-7 in drug treated groups (V, VI, VII), thereafter it decreased tip to day-28. After combined treatment of radiation and cadmium chloride synergistic effects were observed. The Aloe vera treated animals exhibited less severe damage as compared to non-drug treated animals at all the corresponding intervals. An early and fast recovery was noticed in Aloe vera pretreated animals. Thus, it appears that Aloe vera is potent enough to check cadmium and radiation induced haematological changes in the Swiss albino mice. (author)

Protective role of aloe vera against radiation and cadmium induced biochemical changes in the jejunum of Swiss albino mice

International Nuclear Information System (INIS)

Purohit, R.K.; Bhartiya, K.M.; Agarwal, Manisha; Swami, Rajesh; Chakrawarti, Aruna; Meena, Dharmpal

2007-01-01

Full text: The extensive use of atomic energy now a days in various branches of natural economy, science and technology, radio diagnosis, radiotherapy, industries, agriculture, nuclear research etc. has made radiation injury an urgent problem attracting the attention not only of specialists in a variety of clinical disciplines but also of a vast army of theoretical scientists. Metals like cadmium have always been intrinsic components of earth crust with the continuing trends towards and increasing human activities involving man may become exposed to concentration of toxic metals presenting a potential threat for survival. The severity of the damage can be modulated by treating the animals with antioxidants. In view of the potential for practical application, a variety of compounds are being tested for their radio protective activities. Among these, Aloe vera hold a great promise. Aloe vera juice was obtained from Millennium Agro Company, Goregaon (W) Mumbai. It is a herbal drug and known to contain well over 100 separate ingredients or constituents between those found in the leaf and mucilaginous gel inside the leaf. In light of the above, the present study was aimed to evaluate the protective effect of Aloe vera against radiation and cadmium induced biochemical changes in the jejunum Swiss albino mice. For this purpose, healthy adult male Swiss albino mice were divided into seven groups. Group I included sham-irradiated normal mice. Group II was administered CdCl 2 at the dose of 20ppm, while Group III was exposed to 5.0 Gy of gamma radiation. Animals of Group IV were treated with both CdCl 2 and 5.0 Gy of gamma rays. The animals of Group V and VI were treated with CdCl 2 + Aloe vera and 5.0Gy + Aloe vera respectively, whereas Group VII was treated with CdCl 2 +5.0Gy+ Aloe vera. In the groups V, VI and VII the Aloe vera was given seven days prior to the treatment of CdCl 2 or gamma rays. Three animals from all the experimental groups were sacrificed by cervical

Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.

Science.gov (United States)

Sahebnasagh, Adeleh; Ghasemi, Arash; Akbari, Jafar; Alipour, Abbas; Lashkardoost, Hossein; Ala, Shahram; Salehifar, Ebrahim

2017-11-01

Acute radiation proctitis (ARP) is a common side-effect that affects up to 50% of patients receiving radiotherapy. The aim of this study was to evaluate the role of a topical preparation of Aloe vera in the treatment of ARP induced by radiotherapy of pelvic area. In this double-blind placebo-controlled trial, 20 consecutive patients with ARP after external-beam radiation therapy (46-72 Gy) of pelvic malignancies were randomized to receive either Aloe vera 3% or placebo ointment, 1 g twice daily for 4 weeks. These patients presented with at least two of the following symptoms: rectal bleeding, abdominal/rectal pain, diarrhea, or fecal urgency. These symptoms were rated by the patients in terms of their severity (grade 0-4) for each of the symptoms mentioned earlier at baseline and then weekly for 4 weeks. A symptom index was calculated by the addition of the scores (16 most symptomatic). Radiation Therapy Oncology Group (RTOG) acute toxicity criteria and psychosocial status of the patients were also recorded weekly. The lifestyle impact of the symptoms was assessed by questionnaire grading from 0 (no effect on daily activity) to 4 (afraid to leave home). There was a significant (p Aloe vera) for diarrhea (median score: 0.67 vs. 0.11), fecal urgency (median score: 0.89 vs. 0.11), clinical presentation total (median score: 4.33 vs. 1.22), RTOG total (median score: 2.89 vs. 0.89), and lifestyle (median score: 1.1 vs. 0.33). Hemorrhage and abdominal/rectal pain did not improve significantly. The odds ratios for advantage of Aloe vera over placebo for "clinical presentation total" and "RTOG total" were 3.97 (1.3-11.9) and 5.9 (1.6-21.6), respectively. A substantial number of patients with radiation proctitis seem to benefit from therapy with Aloe vera 3% ointment.

New microfungi records on pistachio ( Pistacia vera L.) from ...

African Journals Online (AJOL)

Pistacia L. belongs to the family of Anacardiaceae. It contains nine species and five subspecies. P. vera L. (cultivated pistachio) is the economically most important species in the genus. It has edible seeds and considerable commercial importance. Iran, the United States, Turkey and Syria are the main pistachio producers in ...

Combination of Aloe vera and xenograft induction on decreasing of NF-kb of tooth extraction socket preservation in Cavia cobaya

Directory of Open Access Journals (Sweden)

Utari Kresnoadi

2014-03-01

Full Text Available Background: Tooth extraction can naturally cause inflammation triggering osteoclast proliferation and alveolar bone resorption. Preservation of the tooth extraction sockets is needed for patients in order to reduce alveolar bone resorption risks. Aloe vera is known to have anthraquinones components, namely Aloin, Aloe emedin, and barbaloin, considered as anti-inflammation. Therefore, to overcome the inflammation, the role of NF-kb is very significant to decrease nuclear factor kappa b (NF-kb. As a result, inflammation risks will be decreased. Purpose: The study was aimed to determine the induction effect of combination of Aloe vera and XCB into tooth extraction sockets to reduce inflammation by reducing NF-kb expression, osteoclasts and osteoblasts. Methods: Forty-eight Cavia cobaya were divided into eight groups, each group consisted of six animals. The mandibular incisors of those Cavia cobaya were extracted and induced with either PEG, XCB, Aloe vera, or the combination of Aloe vera + XCB. Those animals were sacrificed on day 7 and day 30 after the extraction. Then immunohistochemical and histopathology examinations were conducted to observe NF-kb expression, osteoblasts and osteoclasts. Results: It was known that in group induced with the combination of Aloe vera and xenograft concelous bovine, the growth of osteoblasts was high, while NF-kb expression and osteoclasts reduced. Conclusion: It can be concluded that the induction of the combination of Aloe vera and XCB into the tooth extraction sockets can reduce NF-kb expression and osteoclast, as a result, alveolar bone resorption risks decrease, and osteoblast increase.Latar belakang: Trauma mekanis akibat pencabutan gigi asli menyebabkan keradangan. Keradangan memicu proliferasi osteoklas sehingga menyebabkan resorpsi tulang alveolararis. Pada pembuatan gigi tiruan, resorpsi tulang alveolar yang terjadi, sangat tidak diinginkan, sebab resorpsi tulang alveolar mengurangi keberhasilan

Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis

DEFF Research Database (Denmark)

Hasselbalch, Hans K

2012-01-01

The morbidity and mortality of patients with the chronic Philadelphia-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia, polycythemia vera, and primary myelofibrosis are mainly caused by cardiovascular diseases, thrombohemorrhagic complications, and bone marrow failure because...

Radical quenching by rosmarinic acid from Lavandula vera MM cell culture.

Science.gov (United States)

Kovacheva, Elena; Georgiev, Milen; Pashova, Svetlana; Angelova, Maria; Ilieva, Mladenka

2006-01-01

This study was conducted to evaluate the radical scavenging capacities of extracts and preparations from a Lavandula vera MM plant cell culture with different rosmarinic acid content and to compare them with pure rosmarinic and caffeic acids as well. The methods, which were used are superoxide anion and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals scavenging assays. Results showed that extracts and preparations from Lavandula vera MM possess strong radical scavengers, as the best both radical scavengers appeared to be the fractions with enriched rosmarinic acid content, obtained after ethylacetate fractioning (47.7% inhibition of superoxide radicals and 14.2 microM 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid equivalents, respectively). These data reveal the possibilities for application of these preparations as antioxidants.

Extent of Use of Aloe vera Locally Extracted Products for Management of Ailments in Communities of Kitagata Sub-county in Sheema District, Western Uganda

Science.gov (United States)

Adams, Kamukama; Eliot, Twineomujuni; Gerald, Agaba

2015-01-01

Aloe vera is widely used locally in communities in Uganda as a medicinal plant. It is said to contain various nutrient substances and vitamins that have curative properties. It is said to heal a variety of diseases in various communities. However the extent of use of this potential medicinal plant in Uganda and the various ailments for which it is used and the treatment outcomes are not clearly established and documented. In this cross-sectional study, carried out in August 2012 in Kitagata sub-county in Sheema district in western Uganda, data was collected from 131 randomly selected adult respondents using an interviewer administered semi-structured questionnaire. Key informants interviews and focused group discussions were also carried out with purposively selected participants. Data were collected on social demographic characteristics, practices and beliefs about Aloe vera. The data were analyzed using Excel version 2007 and Epi_Info software. To get the proportion of the community that use Aloe vera, the number of respondents that use aloe vera was expressed as a percentage of the total number of respondents. It was found out that all the respondents (100%) know aloe vera plant, 96.1% think that it can cure and 84.7% have ever used it. 90.9% of the respondents believe that Aloe vera is effective in curing ailments. 82.9% of these strongly believe in Aloe vera’s effectiveness. The diseases reported included malaria (31%), wounds (23%), abdominal pains (16%) and skin diseases (9%) among others. It was significantly noted that all the participants who had ever used Aloe vera still believe in it. 92.0% respondents reported that they can recommend aloe vera to a friend or relative. Only one participant strongly disagrees that Aloe vera has any curative properties and has never used it. PMID:26855960

Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review.

Science.gov (United States)

Lee, Jeonghun; Lee, Mi Sun; Nam, Kwan Woo

2014-07-01

Aloe is one of the leading products used in phytomedicine. Several cases of aloe-induced toxic hepatitis have been reported in recent years. However, its toxicology has not yet been systematically described in the literature. A 21-year-old female patient was admitted to our hospital with acute hepatitis after taking an aloe vera preparation for four weeks. Her history, clinical manifestation, laboratory findings, and histological findings all led to the diagnosis of aloe vera-induced toxic hepatitis. We report herein on a case of acute toxic hepatitis induced by aloe vera.

Characterization of green synthesized nano-formulation (ZnO-A. vera) and their antibacterial activity against pathogens.

Science.gov (United States)

Qian, Yiguang; Yao, Jun; Russel, Mohammad; Chen, Ke; Wang, Xiaoyu

2015-03-01

The application of nanotechnology in medicine has recently been a breakthrough in therapeutic drugs formulation. This paper presents the structural and optical characterization of a new green nano-formulation (ZnO-Aloe vera) with considerable antibacterial activity against pathogenic bacteria. Its particle structure, size and morphology were characterized by XRD, TEM and SEM. And optical absorption spectra and photoluminescence were measured synchronously. Their antibacterial activity against Escherichia coli and Staphylococcus aureus was also investigated using thermokinetic profiling and agar well diffusion method. The nano-formulation is spherical shape and hexagonal with a particle size ranging from 25 to 65 nm as well as an increased crystallite size of 49 nm. For antibacterial activity, the maximum inhibition zones of ZnO and ZnO+A. vera are 18.33 and 26.45 mm for E. coli, 22.11 and 28.12 mm for S. aureus (pvera nano-formulation has a significant (p E. coli at 15 and 25mg/L. ZnO+A. vera nano-formulation is much more toxic against S. aureus than E. coli, with an IC50 of 13.12 mg/L and 21.31 mg/L, respectively. The overall results reveal that the ZnO-A. vera nano-formulation has good surface energy, crystallinity, transmission, and enriched antibacterial activities. Their antibacterial properties are possibly relevant to particle size, microstructural ionization, the crystal formation and the Gram property of pathogens. This ZnO-A. vera nano-formulation could be utilized effectively as a spectral and significant antibacterial agent for pathogens in future medical and environmental concerns. Copyright © 2015 Elsevier B.V. All rights reserved.

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats.

Science.gov (United States)

Coelho, Fernanda Hack; Salvadori, Gabriela; Rados, Pantelis Varvaki; Magnusson, Alessandra; Danilevicz, Chris Krebs; Meurer, Luise; Martins, Manoela Domingues

2015-07-01

The effect of topical application of Aloe Vera (Aloe barbadensis Miller) extract was assessed on the healing of rat oral wounds in an in vivo model using 72 male Wistar rats divided into three groups (n = 24): control, placebo and Aloe Vera (0.5% extract hydroalcoholic). Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool. The Aloe Vera and placebo group received two daily applications. The animals were sacrificed after 1, 5, 10 and 14 days. Clinical analysis (ulcer area and percentage of repair) and histopathological analysis (degree of re-epithelialization and inflammation) were performed. The comparison of the differences between scores based on group and experimental period, both in quantitative and semi-quantitative analyses, was performed using the Kruskal-Wallis test. The significance level was 5%. On day 1, all groups showed predominantly acute inflammatory infiltrate. On day 5, there was partial epithelialization and chronic inflammatory infiltrate. On the days 10 and 14 total repair of ulcers was observed. There was no significant difference between groups in the repair of mouth ulcers. It is concluded that treatment using Aloe Vera as an herbal formulation did not accelerate oral wound healing in rats. Copyright © 2015 John Wiley & Sons, Ltd.

Comparative study of antimicrobial activities of Aloe vera extracts ...

African Journals Online (AJOL)

Plants are of relevance to dermatology for both their beneficial and adverse effects on skin and skin disorders. One of the medicinal plants, Aloe vera (Aloe barbadensis Miller), is reputed to have medicinal properties. For centuries, it has been used for an array of ailments such as mild fever, wounds and burns, ...

Enhanced biocompatibility of ZnS:Mn quantum dots encapsulated with Aloe vera extract for therapeutic applications

Science.gov (United States)

Anilkumar, M.; Bindu, K. R.; Sneha Saj, A.; Anila, E. I.

2016-08-01

Toxicity of nanoparticles remains to be a major issue in their application to the biomedical field. Aloe vera (AV) is one of the most widely exploited medicinal plants that have a multitude of amazing properties in the field of medicine. Methanol extract of Aloe vera can be used as a novel stabilising agent for quantum dots to reduce toxicity. We report the synthesis, structural characterization, antibacterial activity and cytotoxicity studies of ZnS:Mn quantum dots synthesized by the colloidal precipitation method, using methanol extract of Aloe vera (AVME) as the capping agent. The ZnS:Mn quantum dots capped with AVME exhibit superior performances in biocompatibility and antibacterial activity compared with ZnS:Mn quantum dots without encapsulation. Project supported by the Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India.

The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera

Science.gov (United States)

Pieri, Lisa; Bogani, Costanza; Guglielmelli, Paola; Zingariello, Maria; Rana, Rosa Alba; Bartalucci, Niccolò; Bosi, Alberto; Vannucchi, Alessandro M.

2009-01-01

Background The JAK2V617F mutation has been associated with constitutive and enhanced activation of neutrophils, while no information is available concerning other leukocyte subtypes. Design and Methods We evaluated correlations between JAK2V617F mutation and the count of circulating basophils, the number of activated CD63+ basophils, their response in vitro to agonists as well as the effects of a JAK2 inhibitor. Results We found that basophil count was increased in patients with JAK2V617F -positive myeloproliferative neoplasms, particularly in those with polycythemia vera, and was correlated with the V617F burden. The burden of V617F allele was similar in neutrophils and basophils from patients with polycythemia vera, while total JAK2 mRNA content was remarkably greater in the basophils; however, the content of JAK2 protein in basophils was not increased. The number of CD63+ basophils was higher in patients with polycythemia vera than in healthy subjects or patients with essential thrombocythemia or primary myelofibrosis and was correlated with the V617F burden. Ultrastructurally, basophils from patients with polycythemia vera contained an increased number of granules, most of which were empty suggesting cell degranulation in vivo. Ex vivo experiments revealed that basophils from patients with polycythemia vera were hypersensitive to the priming effect of interleukin-3 and to f-MLP-induced activation; pre-treatment with a JAK2 inhibitor reduced polycythemia vera basophil activation. Finally, we found that the number of circulating CD63+ basophils was significantly greater in patients suffering from aquagenic pruritus, who also showed a higher V617F allele burden. Conclusions These data indicate that the number of constitutively activated and hypersensitive circulating basophils is increased in polycythemia vera, underscoring a role of JAK2V617F in these cells’ abnormal function and, putatively, in the pathogenesis of pruritus. PMID:19608683

Mitigation by Aloe Vera of cadmium chloride and radiation induced biochemical changes in the brain of Swiss albino mice

International Nuclear Information System (INIS)

Chakrawarti, Aruna; Kanwar, Om; Nayak, Kamal Kumar; Ranga, Deepti; Jangir, Ashok; Ram, Purkha

2013-01-01

Whole body exposure to ionizing radiation provokes oxidative damage, organ dysfunction and metabolic disturbance. Herbal drugs offer an alternative to the synthetic radioprotective compounds which are either non-toxic or less toxic. Aloe vera rich in polyphenolic compound is known to possess antioxidant properties. In the context, the present study, effect of Aloe vera against radiation and cadmium induced changes in the brain of Swiss albino mice. For the purpose, six to eight weeks old male Swiss albino mice were selected and divided into seven groups:- Group I (Sham-irradiated), Group II (treated with cadmium chloride 20 ppm), Group III (Irradiated with 7.0 Gy gamma rays), Group IV (Both irradiated and treated with cadmium chloride solution), Group V (Cadmium and Aloe vera treated), Group VI (radiation and Aloe vera treated), Group VII (radiation, and cadmium chloride and Aloe vera treated). The animals were sacrificed by cervical dislocation at each post-treatment intervals of 1, 2, 4, 7, 14 and 28 days. The brain (cerebral cortex) was taken out and quantitatively analyzed for different biochemical parameters such as total proteins, glycogen, cholesterol, acid phosphatase activity, alkaline phosphatase activity, DNA and RNA. The value of cholesterol, glycogen, RNA, acid phosphatase activity, and alkaline phosphatase activity increased up to day-14 in non drug-treated groups and day-7 in Aloe vera treated groups and thereafter decreased up to day-28. The value of total proteins and DNA decreased up to day-14 in non drug-treated groups and day-7 in the drug treated groups then increased in all groups. In only cadmium chloride (Without and with drug) treated animals (Groups II and V) the value of cholesterol decreased during early intervals (days-14 and 7 respectively) and increased thereafter. Severe changes were observed after combined exposure to radiation and cadmium chloride showing synergistic effect. Aloe vera reduced the severity of damage and made the

Preparation and characterization of novel wound dressing based on silver nanoparticle-impregnated bacterial cellulose and bacterial cellulose-aloe vera

International Nuclear Information System (INIS)

Ventigan, Sarla V.; Santiago, Karen S.; Balitaan, Jolleen Natalie I.

2015-01-01

Ideal wound dressings stimulate wound healing, control unpleasant odors, and provide antimicrobial action in wounds. However, most traditional wound dressings such as gauze and biological dressings exhibit exudate leaking which increases the risk of infection and delayed wound healing of tissues. This study aims to develop and characterize a bio-composite of bacterial cellulose and aloe vera having the ideal features of a wound dressing from Acetobacter xylinum-activated culture medium supplemented with various aloe vera concentrations from )-50% (v/v) and the film which exhibits the most uniform results is used for the incorporation of silver nanoparticle as an antibacterial agent. The biopolymer composites of bacterial cellulose and aloe vera were developed by adding 0-50% aloe vera (v/v) in the A. xylinum-activated coconut water medium during biosynthesis in static cultivation for 10 days. The films obtained after drying the membranes were named as bacterial cellulose-aloe vera (BC-A) films. The moisture content of films reached 99% which indicates that the films may be suitable for providing a moist environment to facilitate wound healing fast. With the addition of aloe vera up to 30% (v/v) during BC synthesis, it resulted in a significant improvement in the water absorption capacity of the films showing a WAC ration of 36.46 (r.s.d.= 12.17%, n=3) compared to the unmodified film having a ratio of 9.03 (r.s.d.= 13.95%, n=3). However, the addition of aloe vera at a concentration greater than 30% (v/v) resulted in a decrease in pellicle formation which can be observed from the very weak properties of the films. The BC-A (30%) displayed significantly improved in comparison to the unmodified BC film. Also, it is capable of absorbing high amount of water than its weight and can act as a potential wound dressing which reduces irritation and inflammation. (author)

Lack of Prophylactic Effects of Aloe Vera Gel on Radiation Induced Dermatitis in Breast Cancer Patients

OpenAIRE

Ahmadloo, Niloofar; Kadkhodaei, Behnam; Omidvari, Shapour; Mosalaei, Ahmad; Ansari, Mansour; Nasrollahi, Hamid; Hamedi, Sayed Hasan; Mohammadianpanah, Mohammad

2017-01-01

Purpose: Radiotherapy induced dermatitis is a common and sometimes serious side effect. We conducted a randomized study to understand whether the adjunctive use of aloe vera gel might reduce the prevalence and/or severity of radiotherapy induced dermatitis. Methods: One hundred patients with newly diagnosed breast cancer were randomized to receive aloe vera gel or nothing during adjuvant radiotherapy consisting of conventional external beam radiation using 6 MV mega voltage linear accelerator...

Fungi associated with base rot disease of aloe vera ( Aloe ...

African Journals Online (AJOL)

Fungi associated with base rot disease of Aloe vera (syn. Aloe barbadensis) were investigated in Niger Delta Area of Nigeria. Fungi and their percentage frequency were Aspergillus verocosa 28.03%, Fusarium oxysporium 24.24%, Plectosphaerella cucumerina 16.67%, Mammeria ehinobotryoides 15.91% and Torula ...

Understanding Potential Changes to the Veterans Equitable Resource Allocation (VERA) System

National Research Council Canada - National Science Library

Wasserman, Jeffrey

2004-01-01

... disabilities, low incomes, and special health care needs. In contrast to earlier VHA allocation systems, which were based largely on historical costs, VERA bases its allocation of finds primarily on the number of veterans served (work- load...

Aloe vera: Potential candidate in health management via modulation of biological activities

Science.gov (United States)

Rahmani, Arshad H.; Aldebasi, Yousef H.; Srikar, Sauda; Khan, Amjad A.; Aly, Salah M.

2015-01-01

Treatment based on natural products is rapidly increasing worldwide due to the affordability and fewer side effects of such treatment. Various plants and the products derived from them are commonly used in primary health treatment, and they play a pivotal role in the treatment of diseases via modulation of biochemical and molecular pathways. Aloe vera, a succulent species, produces gel and latex, plays a therapeutic role in health management through antioxidant, antitumor, and anti-inflammatory activities, and also offers a suitable alternative approach for the treatment of various types of diseases. In this review, we summarize the possible mechanism of action and the therapeutic implications of Aloe vera in health maintenance based on its modulation of various biological activities. PMID:26392709

Fumaric acid, an antibacterial component of Aloe vera L. | He ...

African Journals Online (AJOL)

The acetoacetate fraction partitioned from Aloe vera L. showed an effective antibacterial activity against four clinically frequent pathogenic bacteria. Through a series of chromatographic methods and activity assays, one compound was obtained and it has potent antibacterial activity. Based on the data of mass spectrometry, ...

Polycythemia vera presenting with bilateral papilledema: A rare case report

Directory of Open Access Journals (Sweden)

Parija S

2008-01-01

Full Text Available A 45-year-old male patient presented with gradual onset of headache, vomiting and blurring of vision of 28 days duration. Ophthalmological examination revealed normal anterior segment and pupillary reflex. No abnormality was detected in the vitreous. Optic disc showed features of advanced papilledema with normal macula and retinal periphery in both eyes. Visual acuity was 20/200 in the right eye and counting fingers close range in the left eye. Non-contrast computed tomography of brain was normal and magnetic resonance imaging showed sagittal sinus thrombosis without any evidence of venous infarction or intracranial mass. Routine hematological investigations revealed increased hemoglobin level, packed cell volume and leucocytosis. Further investigation revealed increased Vitamin B12 and decreased serum erythropoietin. A diagnosis of polycythemia vera was made from the above findings. This case is being presented for the rarity of association of polycythemia vera with bilateral advanced papilledema due to sagittal sinus thrombosis.

Cuatro altares de La Vera, Cáceres

Directory of Open Access Journals (Sweden)

Gómez-Pantoja, Joaquín L.

2013-12-01

Full Text Available This paper describes four Roman altars recently found in La Vera, which is the name given to the country lying between Tiétar river and Sierra de Gredos, in the Spanish province of Cáceres. Of the nine inscriptions, three epigraphs are dedications to local deities: Band(- Vortiacius, a new divine couple, Ulisus and Ulisona; and Quangeius, this one being placed in fano, which is the second occurrence of that word in Spanish epigraphy. The last piece is a tombstone so dilapidated that it is difficult to tell apart even the normal features of an ancient epitaph.Se describen cuatro altares inscritos recientemente descubiertos en La Vera, comarca cacereña situada en la orilla septentrional del río Tiétar. De las nuevas inscripciones, tres son altares dedicados a lo que se han llamado “dioses indígenas”: Band(- Vortiacius, lo que parece una nueva paredría (Ulisus y Ulisona y Quangeius; nótese que este se colocó in fano, la segunda mención epigráfica del término aparecida hasta ahora en la Península. La última pieza es un epitafio, pero tan estropeado por la erosión, que apenas se reconocen los elementos característicos de esta clase de epígrafes.

Assessment of Chronic Administration of Aloe Vera Gel On ...

African Journals Online (AJOL)

The study was designed to investigate the effects of chronic administration of Aloe vera gel extract on markers of hepatic damage, lipid profiles and erythrocyte osmotic fragility using the Wistar rats. Forty male Wistar rats divided into four groups of ten rats per group were used in the study. Group I which served as the control ...

THE EFFECT OF ALOE VERA ON GASTRIC ACID SECRETION ...

African Journals Online (AJOL)

The effect of varying doses of ethanol extract of Aloe vera (Liliaceae) on acute gastric mucosal lesions induced by 0.6M HCl and acid output was studied in the pylorus ligated and lumen perfuse rats respectively. Acid secretion was determined by titration of the collected gastric juice to pH 7.0. Intraperitoneal injection of Aloe ...

Insecticidal and insect productivity reduction capacities of aloe vera ...

African Journals Online (AJOL)

Two important medicinal plants, Aloe vera and Bryophyllum pinnatum were admixed with maize grains (Popcorn) at dosages of 1g, 2g and 5g treatments per 50g of maize. Results showed that both lower and higher dosages had toxic effects on Tribolium castaneum but the best results were obtained in the grains treated ...

In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel.

Science.gov (United States)

Kang, Min-Cheol; Kim, Seo Young; Kim, Yoon Taek; Kim, Eun-A; Lee, Seung-Hong; Ko, Seok-Chun; Wijesinghe, W A J P; Samarakoon, Kalpa W; Kim, Young-Sun; Cho, Jin Hun; Jang, Hyeang-Su; Jeon, You-Jin

2014-01-01

The in vitro and in vivo antioxidant potentials of a polysaccharide isolated from aloe vera gel were investigated. Enzymatic extracts were prepared from aloe vera gel by using ten digestive enzymes including five carbohydrases and five proteases. Among them, the highest yield was obtained with the Viscozyme extract and the same extract showed the best radical scavenging activity. An active polysaccharide was purified from the Viscozyme extract using ethanol-added separation and anion exchange chromatography. Purified aloe vera polysaccharide (APS) strongly scavenged radicals including DPPH, hydroxyl and alkyl radicals. In addition, APS showed a protective effect against AAPH-induced oxidative stress and cell death in Vero cells as well as in the in vivo zebrafish model. In this study, it is proved that both the in vitro and in vivo antioxidant potentials of APS could be further utilized in relevant industrial applications. Copyright © 2013 Elsevier Ltd. All rights reserved.

European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP): a randomized trial.

Science.gov (United States)

Landolfi, R; Marchioli, R

1997-01-01

Thrombotic complications characterize the clinical course of polycythemia vera (PV) and represent the main cause of morbidity and mortality. However, uncertainty still exists as to the benefit/risk ratio of aspirin prophylaxis in this setting. In vivo platelet biosynthesis of thromboxane A2 is enhanced and can be suppressed by low-dose aspirin in PV, thus providing a rationale for assessing the efficacy and safety of a low-dose aspirin regimen in these patients. The Gruppo Italiano Studio Policitemia Vera has recently performed a pilot study on 112 patients randomized to receive aspirin, 40 mg daily, or placebo and followed for 16 +/- 6 months (mean +/- SD). This study showed that low-dose aspirin is well tolerated in PV patients, and that a large-scale efficacy trial is feasible in this setting. In this article we report the protocol of the European Collaboration on Low-dose Aspirin in Polycythemia Vera (ECLAP) study, which is a randomized trial designed to assess the risk/benefit ratio of low-dose aspirin in PV. To estimate the size and the follow-up duration required for the ECLAP trial, a retrospective analysis of the clinical epidemiology of a large PV population has recently been completed by the Gruppo Italiano Studio Policitemia Vera. On this basis, approximately 3500 patients will be enrolled in the ECLAP study with a follow-up of 3 to 4 years. The uncertainty principle will be used as the main eligibility criterion: Polycythemic patients of any age, having no clear indication for or contraindication to aspirin treatment, will be randomized in a double-blind fashion to receive oral aspirin (100 mg daily) or placebo. According to current therapeutic recommendations, the basic treatment of randomized patients should be aimed at maintaining the hematocrit value 50. Randomization will be stratified by participating center. The study is funded by the European Union BIOMED 2 program.

Sensitivity analysis of VERA-CS and FRAPCON coupling in a multiphysics environment

International Nuclear Information System (INIS)

Blakely, Cole; Zhang, Hongbin; Ban, Heng

2018-01-01

Highlights: •VERA-CS and FRAPCON coupling. •Uncertainty quantification and sensitivity analysis for coupled VERA-CS and FRAPCON simulations in a multiphysics environment LOTUS. -- Abstract: A demonstration and description of the LOCA Toolkit for US light water reactors (LOTUS) is presented. Through LOTUS, the core simulator VERA-CS developed by CASL is coupled with the fuel performance code FRAPCON. The coupling is performed with consistent uncertainty propagation with all model inconsistencies being well-documented. Monte Carlo sampling is performed on a single 17 × 17 fuel assembly with a three cycle depletion case. Both uncertainty quantification (UQ) and sensitivity analysis (SA) are used at multiple states within the simulation to elucidate the behavior of minimum departure from nucleate boiling ratio (MDNBR), maximum fuel centerline temperature (MFCT), and gap conductance at peak power (GCPP). The SA metrics used are the Pearson correlation coefficient, Sobol sensitivity indices, and the density-based, delta moment independent measures. Results for MDNBR show consistency among all SA measures, as well for all states throughout the fuel lifecycle. MFCT results contain consistent rankings between SA measures, but show differences throughout the lifecycle. GCPP exhibits predominantly linear relations at low and high burnup, but highly nonlinear relations at intermediate burnup due to abrupt shifts between models. Such behavior is largely undetectable to traditional regression or variance-based methods and demonstrates the utility of density-based methods.

Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction.

Science.gov (United States)

El-Shemy, H A; Aboul-Soud, M A M; Nassr-Allah, A A; Aboul-Enein, K M; Kabash, A; Yagi, A

2010-01-01

The aim of this study was to evaluate the potential anticancer properties and modulatory effect of selected Aloe vera (A. vera) active principles on antioxidant enzyme activities. Thus, three anthraquinones (Namely: aloesin, aloe-emodin and barbaloin) were extracted from A. vera leaves by supercritical fluid extraction and subsequently purified by high performance liquid chromatography. Additionally, the N-terminal octapeptide derived from verectin, a biologically active 14 kDa glycoprotein present in A. vera, was also tested. In vivo, active principles exhibited significant prolongation of the life span of tumor-transplanted animals in the following order: barbaloin> octapeptide> aloesin > aloe-emodin. A. vera active principles exhibited significant inhibition on Ehrlich ascite carcinoma cell (EACC) number, when compared to positive control group, in the following order: barbaloin> aloe-emodin > octapeptide > aloesin. Moreover, in trypan blue cell viability assay, active principles showed a significant concentration-dependent cytotoxicity against acute myeloid leukemia (AML) and acute lymphocytes leukemia (ALL) cancerous cells. Furthermore, in MTT cell viability test, aloe-emodin was found to be active against two human colon cancer cell lines (i.e. DLD-1 and HT2), with IC(50) values of 8.94 and 10.78 microM, respectively. Treatments of human AML leukemic cells with active principles (100 microg ml(-1)) resulted in varying intensities of internucleosomal DNA fragmentation, hallmark of cells undergoing apoptosis, in the following order: aloe-emodin> aloesin> barbaloin> octapeptide. Intererstingly, treatment of EACC tumors with active principles resulted in a significant elevation activity of key antioxidant enzymes (SOD, GST, tGPx, and LDH). Our data suggest that the tested A. vera compounds may exert their chemo-preventive effect through modulating antioxidant and detoxification enzyme activity levels, as they are one of the indicators of tumorigenesis. These

Síndrome de Sweet associada à policitemia vera Sweet’s syndrome associated withpolycythemiavera

Directory of Open Access Journals (Sweden)

Ângela Puccini Moreira

2009-12-01

Full Text Available A síndrome de Sweet pode estar associada a malignidades hematológicas, principalmente, à leucemia mieloide aguda, porém existem poucos relatos demonstrando a associação com a policitemia vera. Relata-se o caso de doente do sexo masculino, de 65 anos, portador de policitemia vera,que evoluiu com aparecimento de síndrome de Sweet na sua forma paraneoplásica.Sweet’s syndrome may be associated with hematological malignancies, particularly with acute myelogenous leukemia, but there are few reports of its association with polycythemiavera. We describethe case of a 65-year-old male patient, diagnosed with polycythemiavera, which developedinto paraneoplastic Sweet's syndrome.

Economic Sustainability of Organic Aloe Vera Farming in Greece under Risk and Uncertainty

Directory of Open Access Journals (Sweden)

Angelos Liontakis

2016-04-01

Full Text Available During the last decade, an encouraging environment for the restructuring and modernization of the agricultural sector has formed in Greece. The diversification into higher-value crops can be a promising option for small and average-sized farms, particularly during the current economic crisis. One of the most promising alternative crops that have been recently established in Greece is the organic Aloe vera crop. The main advantage of this crop is that it can utilize poor farmlands and, therefore, can facilitate rural development in marginal areas. This study explores the economic sustainability of the Aloe vera crop, considering the embedded risk and uncertainty. The results indicate that organic aloe farming is a promising alternative to “traditional” crops in Greece, particularly for family farms in rural areas. In contrast, this activity is not advisable to the most entrepreneurial type of farmers, unless their crop size allows economies of scales. Finally, the Stochastic Efficiency with Respect to a Function (SERF analysis associates farmers’ risk attitude with their willingness to be involved in organic Aloe vera farming. SERF analysis highlights the crucial role of farmers’ risk aversion and concludes that, above a certain level of risk aversion, farmers have no incentive to adopt this economic activity.

Review of Clinical Pharmacology of Aloe vera L. in the Treatment of Psoriasis.

Science.gov (United States)

Miroddi, Marco; Navarra, Michele; Calapai, Fabrizio; Mancari, Ferdinando; Giofrè, Salvatore Vincenzo; Gangemi, Sebastiano; Calapai, Gioacchino

2015-05-01

Aloe vera L., is a plant used worldwide as folk remedy for the treatment of various ailments, including skin disorders. Its gel is present in cosmetics, medicinal products and food supplements. Psoriasis, an immune-mediated chronic inflammatory disease, involving mainly the skin, affects about the 2-3% of general population. Conventional pharmacological treatments for psoriasis can have limited effectiveness and can cause adverse reactions. For this reason often psoriatic patients look for alternative treatments based on natural products containing Aloe vera. We conducted a systematic review of clinical trials assessing effectiveness and safety of aloe for the treatment of psoriasis. Clinical studies published in English were considered; a total of four clinical trials met inclusion criteria. Studies were also evaluated by using the Jadad scale and Consort Statement in Reporting Clinical trials of Herbal Medicine Intervention. Quality and methodological accuracy of considered studies varied considerably, and some crucial information to reproduce clinical results was missing. We conclude that administration of aloe as cutaneous treatment is generally well tolerated, as no serious side effects were reported. Results on the effectiveness of Aloe vera are contradictory; our analysis reveals the presence of methodological gaps preventing to reach final conclusions. Copyright © 2015 John Wiley & Sons, Ltd.

Effect of Gelatin-Based Edible Coatings Incorporated with Aloe vera and Black and Green Tea Extracts on the Shelf Life of Fresh-Cut Oranges

Directory of Open Access Journals (Sweden)

Mohsen Radi

2017-01-01

Full Text Available The aim of this study was to evaluate the effect of gelatin coating incorporated with Aloe vera gel (50,100% and green and black tea extracts (5,10% on physicochemical, microbial, and sensorial properties of fresh-cut oranges at 4°C for 17 days. Significant differences in terms of quality parameters were observed between the control and coated fresh-cut oranges. The highest variation of quality parameters was observed in control, while the least variations were observed in coated slices with 100% Aloe vera and 10% green tea extract. The weight loss was increased with time, but the coating treatment especially with 100% Aloe vera had significant effect on the prevention of weight loss. Also, Aloe vera coated samples obtained the highest score in sensory evaluation. Coating with gelatin incorporated with Aloe vera and green tea extracts successfully retarded the microbial growth and therefore extended the shelf life of fresh-cut oranges during cold storage.

African-American Soul Force: Dance, Music and Vera Mae Green.

Science.gov (United States)

Bolles, A. Lynn

1986-01-01

The Black anthropologist, Vera Mae Green, is featured in this analysis of the concept of soul as applied to African-Americans. Music and dance are used to express soul in cultural context. But soul is also a force, an energy which encompasses the Black experience and makes Black culture persevere. (VM)

Structural Modifications of Fructans in Aloe barbadensis Miller (Aloe Vera) Grown under Water Stress.

Science.gov (United States)

Salinas, Carlos; Handford, Michael; Pauly, Markus; Dupree, Paul; Cardemil, Liliana

2016-01-01

Aloe barbadensis Miller (Aloe vera) has a Crassulaceae acid metabolism which grants the plant great tolerance to water restrictions. Carbohydrates such as acemannans and fructans are among the molecules responsible for tolerating water deficit in other plant species. Nevertheless, fructans, which are prebiotic compounds, have not been described nor studied in Aloe vera, whose leaf gel is known to possess beneficial pharmaceutical, nutritional and cosmetic properties. As Aloe vera is frequently cultivated in semi-arid conditions, like those found in northern Chile, we investigated the effect of water deficit on fructan composition and structure. For this, plants were subjected to different irrigation regimes of 100%, 75%, 50% and 25% field capacity (FC). There was a significant increase in the total sugars, soluble sugars and oligo and polyfructans in plants subjected to water deficit, compared to the control condition (100% FC) in both leaf tips and bases. The amounts of fructans were also greater in the bases compared to the leaf tips in all water treatments. Fructans also increase in degree of polymerization with increasing water deficit. Glycosidic linkage analyses by GC-MS, led to the conclusion that there are structural differences between the fructans present in the leaves of control plants with respect to plants irrigated with 50% and 25% FC. Therefore, in non-stressed plants, the inulin, neo-inulin and neo-levan type of fructans predominate, while in the most stressful conditions for the plant, Aloe vera also synthesizes fructans with a more branched structure, the neofructans. To our knowledge, the synthesis and the protective role of neo-fructans under extreme water deficit has not been previously reported.

The potential benefits of using aloe vera in stoma patient skin care.

Science.gov (United States)

Rippon, Mark; Perrin, Angie; Darwood, Richard; Ousey, Karen

2017-03-09

Individuals living with an ostomy may suffer from a variety of peri-stomal skin complications related to the use of their stoma appliance or accessories. These conditions can be serious enough to significantly impact on a patient's quality of life and may result in severe clinical complications (such as infection). This article is a review of the literature with the objective of investigating and presenting evidence for the well-documented use of aloe vera in the prevention of skin conditions similar to those seen in peri-stomal skin complications. An exploration for the potential use of aloe vera directly or indirectly (as an adjunct to medical devices such as wafers) in stoma patients is presented with the view that this use may be beneficial in the prevention of such peri-stomal skin complications.

Antifungal Effect of Malaysian Aloe vera Leaf Extract on Selected Fungal Species of Pathogenic Otomycosis Species in In Vitro Culture Medium.

Science.gov (United States)

Saniasiaya, Jeyasakthy; Salim, Rosdan; Mohamad, Irfan; Harun, Azian

2017-01-01

Aloe barbadensis miller or Aloe vera has been used for therapeutic purposes since ancient times with antifungal activity known to be amongst its medicinal properties. We conducted a pilot study to determine the antifungal properties of Malaysian Aloe vera leaf extract on otomycosis species including Aspergillus niger and Candida albicans. This laboratory-controlled prospective study was conducted at the Universiti Sains Malaysia. Extracts of Malaysian Aloe vera leaf was prepared in ethanol and solutions via the Soxhlet extraction method. Sabouraud dextrose agar cultured with the two fungal isolates were inoculated with the five different concentrations of each extract (50 g/mL, 25 g/mL, 12.5 g/mL, 6.25 g/mL, and 3.125 g/mL) using the well-diffusion method. Zone of inhibition was measured followed by minimum inhibitory concentration (MIC). For A. niger, a zone of inhibition for alcohol and aqueous extract was seen for all concentrations except 3.125 g/mL. There was no zone of inhibition for both alcohol and aqueous extracts of Aloe vera leaf for C. albicans . The MIC values of aqueous and alcohol extracts were 5.1 g/mL and 4.4 g/mL for A. niger and since no zone of inhibition was obtained for C. albicans the MIC was not determined. The antifungal effect of alcohol extracts of Malaysian Aloe vera leaf is better than the aqueous extract for A. niger ( p Malaysian Aloe vera has a significant antifungal effect towards A. niger.

New microfungi records on pistachio (Pistacia vera L.) from ...

African Journals Online (AJOL)

Jane

2011-10-24

Oct 24, 2011 ... material either by scraping, or obtaining with a razor at thin sections. Two types of ... 37°02'08''N 37°18'21''E, 890m, 30.06.2010, DY 10. Pleomassariaceae .... vera) nut production and storage in turkey with particular reference to aflatoxin ... Kirk PM, Cannon PF, Minter DW, Stalpers JA (2008). Dictionary of ...

Antibacterial effect of triantibiotic mixture, chlorhexidine gel, and two natural materials Propolis and Aloe vera against Enterococcus faecalis: An ex vivo study.

Science.gov (United States)

Bazvand, Leila; Aminozarbian, Mohammad Ghasem; Farhad, Alireza; Noormohammadi, Hamid; Hasheminia, Seyed Mohsen; Mobasherizadeh, Sina

2014-07-01

The aim of this ex vivo study was to compare the antimicrobial effect of triantibiotic paste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin. Ninety fresh extracted single-rooted teeth were used in a dentin block model. Seventy-five teeth were infected with E. faecalis and divided into four experimental groups (n = 15). Experimental groups were treated with triantibiotic mixture with distilled water, 0.2% chlorhexidine gel, 70% ethanol + Propolis and Aloe vera. Fifteen teeth treated with distilled water as the positive control and 15 samples, free of bacterial contamination, were considered as the negative control. Gates-Glidden drill #4 was used for removal of surface dentin and Gates-Glidden drill #5 was used to collect samples of deep dentin. The samples were prepared and colony-forming units were counted. Data were analyzed by one-way ANOVA and post hoc Tukey tests. Statistical significance was defined at P 0.05). Aloe vera had antibacterial effects on E. faecalis, but in comparison with other medicaments, it was less effective (P vera were relatively effective against E. faecalis. All the intracanal medicements had similar effects on E. faecalis in deep dentin except for Aloe vera.

The Effects of Aloe vera Cream on the Expression of CD4+ and CD8+ Lymphocytes in Skin Wound Healing.

Science.gov (United States)

Prakoso, Yos Adi; Kurniasih

2018-01-01

The aim of this study is to explore the effect of topical application of Aloe vera on skin wound healing. Thirty-six male Sprague-Dawley rats weighing 150-200 grams were divided into four groups. All groups were anesthetized, shaved, and exposed to round full-thickness punch biopsy on the back: group I (control); group II (treated with 1% Aloe vera cream); group III (treated with 2% Aloe vera cream); and group IV (treated with madecassol®). The treatments were given once a day. Macroscopic and microscopic examination were observed at 5, 10, and 15 days after skin biopsy. Skin specimens were prepared for histopathological study using H&E stain and IHC stain against CD4 + and CD8 + lymphocytes. All the data were analyzed using SPSS16. The result showed that topical application of 1% and 2% Aloe vera cream significantly reduced the percentage of the wound, leucocytes infiltration, angiogenesis, and expression of CD8 + lymphocytes and increased the epidermal thickness and the expression of CD4 + lymphocytes ( p ≤ 0,05). There was no significant difference in the number of fibroblasts in all groups. Topical application of 1% and 2% Aloe vera cream has wound healing potential via their ability to increase the ratio of CD4 + /CD8 + lymphocytes in the wound area.

Immunohistochemical studies on the effect of Aloe vera on the ...

African Journals Online (AJOL)

Address for Correspondence. Immunohistochemical studies on the effect of Aloe vera on the pancreatic β-cells in neonatal streptozotocin-induced type-II diabetic rats. Sema Bolkent 1, Nuriye Akev 2*, Ayşe Can 2, Sehnaz Bolkent 3, Refiye Yanardag 4 &. Alper Okyar 5. 1. Department of Medical Biology, Cerrahpasa Faculty ...

Composite wound dressings of pectin and gelatin with aloe vera and curcumin as bioactive agents.

Science.gov (United States)

Tummalapalli, Mythili; Berthet, Morgane; Verrier, Bernard; Deopura, B L; Alam, M S; Gupta, Bhuvanesh

2016-01-01

Aloe vera and curcumin loaded oxidized pectin-gelatin (OP-Gel) matrices were used as antimicrobial finishes on nonwoven cotton fabrics to produce composite wound care devices. The drug release characteristics of the biocomposite dressings indicated that curcumin is released through a biphasic mechanism - erosion of the polymeric matrix, followed by diffusion, while aloe vera is released upon leaching of the polymeric matrix. A 50/50 composition of aloe vera/curcumin was used to fabricate OP-Gel-Aloe Curcumin dressings. However, contrary to our expectations, OP-Gel-Aloe Curcumin dressings exhibited lesser antimicrobial activity compared to OP-Gel-Aloe and OP-Gel-Curcumin dressings. The cytocompatibility of the fabricated dressings was evaluated using NIH3T3 mouse fibroblast cells. OP-Gel-Aloe treated fibroblasts had the highest viability, with the matrices providing a substrate for good cell attachment and proliferation. On the other hand, OP-Gel-Curcumin and OP-Gel-Aloe Curcumin seemed to have induced apoptosis in NIH3T3 cells. In vivo wound healing analysis was carried out using an excisional splint wound model on C57BL/6J mice. OP-Gel-Aloe treated wounds exhibited very rapid healing with 80% of the wound healing in just 8 days. Furthermore, aloe vera exerted a strong anti-inflammatory effect and prominent scar prevention. Histological examination revealed that an ordered collagen formation and neovascularization could be observed along with migration of nuclei. Therefore, OP-Gel-Aloe biocomposite dressings are proposed as viable materials for effective wound management. Copyright © 2015 Elsevier B.V. All rights reserved.

Interferon and the treatment of polycythemia vera, essential thrombocythemia and myelofibrosis

DEFF Research Database (Denmark)

Silver, Richard T; Kiladjian, Jean-Jacques; Hasselbalch, Hans K

2013-01-01

. In polycythemia vera, this has resulted in a significant clinical, hematologic, morphologic and molecular response manifested by reduction in the JAK2(V617F) allele burden, sustained even after discontinuation of recombinant IFN. In essential thrombocythemia, platelet count reduction is prompt and durable without...

Demonstration of Load-Follow Simulation with VERA-CS and Standalone BISON

Energy Technology Data Exchange (ETDEWEB)

Stimpson, Shane G. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2017-01-24

In this report, load-follow simulations using VERA-CS with one-way coupling to standalone BISON has been demonstrated including both a single rod with a full cycle of load-follow operations and a quarter-core model with a single month of load-follow.

Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity

International Nuclear Information System (INIS)

Williams, Maureen S.; Burk, Mary; Loprinzi, Charles L.; Hill, Mary; Schomberg, Paula J.; Nearhood, Kim; O'Fallon, Judith R.; Laurie, John A.; Shanahan, Thomas G.; Moore, Randy L.; Urias, Rodolfo E.; Kuske, Robert R.; Engel, Roland E.; Eggleston, William D.

1996-01-01

Purpose: Considerable pilot data and clinical experience suggested that an aloe vera gel might help to prevent radiation therapy-induced dermatitis. Methods and Materials: Two Phase III randomized trials were conducted. The first one was double blinded, utilized a placebo gel, and involved 194 women receiving breast or chest wall irradiation. The second trial randomized 108 such patients to aloe vera gel vs. no treatment. Skin dermatitis was scored weekly during both trials both by patients and by health care providers. Results: Skin dermatitis scores were virtually identical on both treatment arms during both of the trials. The only toxicity from the gel was rare contact dermatitis. Conclusions: This dose and schedule of an aloe vera gel does not protect against radiation therapy-induced dermatitis

Preparation and characterization of chitosan/Aloe Vera composite nanofibers generated by electrostatic spinning

Energy Technology Data Exchange (ETDEWEB)

Ibrahim, Illani; Sekak, Khairunnadim Ahmad; Hasbullah, Norazurean [Center of Physics and Material Studies, Faculty of Applied Sciences, Universiti Teknologi Mara (UiTM) 40450 Shah Alam, Selangor (Malaysia)

2015-08-28

Researches on the fabrication of nanostructured based membrane have attracted great attention amongst scientists due to their wide potential applications on medical application. In this work, Chitosan and Aloe Vera sol-gel solution were electrospun using 20 kV DC supply at room temperature. Morphological structure and functional group of nanofibers were characterized using field emission scanning electron microscopy (FESEM) and Fourier-transform infrared spectroscopy (FT-IR) respectively. The optimum parameter obtained at 90% concentration of acetic acid, 0.3 ml/h of solution flow rate and 10 cm distance of nozzle to collector. The fiber diameters were analyzed using the ImageJ software. Average diameters of the Chitosan/Aloe Vera composite nanofibers is 183nm in ranges of 140–260nm.

Preparation and characterization of chitosan/Aloe Vera composite nanofibers generated by electrostatic spinning

International Nuclear Information System (INIS)

Ibrahim, Illani; Sekak, Khairunnadim Ahmad; Hasbullah, Norazurean

2015-01-01

Researches on the fabrication of nanostructured based membrane have attracted great attention amongst scientists due to their wide potential applications on medical application. In this work, Chitosan and Aloe Vera sol-gel solution were electrospun using 20 kV DC supply at room temperature. Morphological structure and functional group of nanofibers were characterized using field emission scanning electron microscopy (FESEM) and Fourier-transform infrared spectroscopy (FT-IR) respectively. The optimum parameter obtained at 90% concentration of acetic acid, 0.3 ml/h of solution flow rate and 10 cm distance of nozzle to collector. The fiber diameters were analyzed using the ImageJ software. Average diameters of the Chitosan/Aloe Vera composite nanofibers is 183nm in ranges of 140–260nm

Preparation and characterization of chitosan/Aloe Vera composite nanofibers generated by electrostatic spinning

Science.gov (United States)

Ibrahim, Illani; Sekak, Khairunnadim Ahmad; Hasbullah, Norazurean

2015-08-01

Researches on the fabrication of nanostructured based membrane have attracted great attention amongst scientists due to their wide potential applications on medical application. In this work, Chitosan and Aloe Vera sol-gel solution were electrospun using 20 kV DC supply at room temperature. Morphological structure and functional group of nanofibers were characterized using field emission scanning electron microscopy (FESEM) and Fourier-transform infrared spectroscopy (FT-IR) respectively. The optimum parameter obtained at 90% concentration of acetic acid, 0.3 ml/h of solution flow rate and 10 cm distance of nozzle to collector. The fiber diameters were analyzed using the ImageJ software. Average diameters of the Chitosan/Aloe Vera composite nanofibers is 183nm in ranges of 140-260nm.

Remembering the short stories of Yvonne Vera: A postcolonial and ...

African Journals Online (AJOL)

This article attempts to redress this scholarly imbalance by offering a close textual analysis of Why Don't You Carve Other Animals? through a critical lens of postcolonial and feminist theory. In these stories Vera articulates the internal thoughts of her characters in order to explore the way that oppressed people negotiate the ...

Strategy of the Synecdoche: The Semiotics of Yvonne Vera in ...

African Journals Online (AJOL)

This paper delineates the complex use of the synecdoche in Yvonne Vera's Butterfly Burning. We will also demonstrate the process by which this solid figure of speech is manipulated to reflect the human anatomy. To do this, we recall that Language is a tool with which writers express their visions. Synecdoche itself is an ...

Distance to VY Canis Majoris with VERA

OpenAIRE

Choi, Yoon Kyung; Hirota, Tomoya; Honma, Mareki; Kobayashi, Hideyuki; Bushimata, Takeshi; Imai, Hiroshi; Iwadate, Kenzaburo; Jike, Takaaki; Kameno, Seiji; Kameya, Osamu; Kamohara, Ryuichi; Kan-ya, Yukitoshi; Kawaguchi, Noriyuki; Kijima, Masachika; Kim, Mi Kyoung

2008-01-01

We report astrometric observations of H2O masers around the red supergiant VY Canis Majoris (VY CMa) carried out with VLBI Exploration of Radio Astrometry (VERA). Based on astrometric monitoring for 13 months, we successfully measured a trigonometric parallax of 0.88 +/- 0.08 mas, corresponding to a distance of 1.14 +0.11/-0.09 kpc. This is the most accurate distance to VY CMa and the first one based on an annual parallax measurement. The luminosity of VY CMa has been overestimated due to a p...

Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin

Energy Technology Data Exchange (ETDEWEB)

Anjum, Sadiya [Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016 (India); Gupta, Amlan; Sharma, Deepika [Department of Pathology, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102 (India); Gautam, Deepti [Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016 (India); Bhan, Surya; Sharma, Anupama [Department of Biochemistry, North Eastern Hill University, Shillong 793022, Meghalaya (India); Kapil, Arti [Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029 (India); Gupta, Bhuvanesh, E-mail: bgupta@textile.iitd.ernet.in [Bioengineering Laboratory, Department of Textile Technology, Indian Institute of Technology, New Delhi 110016 (India)

2016-07-01

This study is aimed at the development of a composite material for wound dressing containing nanosilver nanohydrogels (nSnH) along with Aloe vera and curcumin that promote antimicrobial nature, wound healing and infection control. Nanosliver nanohydrogels were synthesized by nanoemulsion polymerization of methacrylic acid (MAA) followed by subsequent crosslinking and silver reduction under irradiation. Both the polymerization and irradiation time had significant influence on the nanoparticle shape, size and its formation. Polyvinyl alcohol/polyethylene oxide/carboxymethyl cellulose matrix was used as gel system to blend with nSnH, A. vera, curcumin and coat it on the hydrolysed PET fabric to develop antimicrobial dressings. The cumulative release of silver from the dressing was found to be ~ 42% of the total loading after 48 h. The antimicrobial activity of the dressings was studied against both Staphylococcus aureus and Escherichia coli. In vivo wound healing studies were carried out over a period of 16 d on full-thickness skin wounds created on Swiss albino mice. Fast healing was observed in Gel/nSnH/Aloe treated wounds with minimum scarring, as compared to other groups. The histological studies showed A. vera based dressings to be the most optimum one. These results suggest that nSnH along with A. vera based dressing material could be promising candidates for wound dressings. - Highlights: • PMAA based nanosilver nanogels offer excellent antimicrobial property. • nSnH may be coated on a fabric surface to develop wound care dressings. • Dressings show good wound recovery on animal models. • Aloe vera shows better healing behaviour as compared to the curcumin based systems.

Identification of Reference Genes for Quantitative Gene Expression Studies in a Non-Model Tree Pistachio (Pistacia vera L..

Directory of Open Access Journals (Sweden)

Maryam Moazzam Jazi

Full Text Available The tree species, Pistacia vera (P. vera is an important commercial product that is salt-tolerant and long-lived, with a possible lifespan of over one thousand years. Gene expression analysis is an efficient method to explore the possible regulatory mechanisms underlying these characteristics. Therefore, having the most suitable set of reference genes is required for transcript level normalization under different conditions in P. vera. In the present study, we selected eight widely used reference genes, ACT, EF1α, α-TUB, β-TUB, GAPDH, CYP2, UBQ10, and 18S rRNA. Using qRT-PCR their expression was assessed in 54 different samples of three cultivars of P. vera. The samples were collected from different organs under various abiotic treatments (cold, drought, and salt across three time points. Several statistical programs (geNorm, NormFinder, and BestKeeper were applied to estimate the expression stability of candidate reference genes. Results obtained from the statistical analysis were then exposed to Rank aggregation package to generate a consensus gene rank. Based on our results, EF1α was found to be the superior reference gene in all samples under all abiotic treatments. In addition to EF1α, ACT and β-TUB were the second best reference genes for gene expression analysis in leaf and root. We recommended β-TUB as the second most stable gene for samples under the cold and drought treatments, while ACT holds the same position in samples analyzed under salt treatment. This report will benefit future research on the expression profiling of P. vera and other members of the Anacardiaceae family.

Identification of Reference Genes for Quantitative Gene Expression Studies in a Non-Model Tree Pistachio (Pistacia vera L.).

Science.gov (United States)

Moazzam Jazi, Maryam; Ghadirzadeh Khorzoghi, Effat; Botanga, Christopher; Seyedi, Seyed Mahdi

2016-01-01

The tree species, Pistacia vera (P. vera) is an important commercial product that is salt-tolerant and long-lived, with a possible lifespan of over one thousand years. Gene expression analysis is an efficient method to explore the possible regulatory mechanisms underlying these characteristics. Therefore, having the most suitable set of reference genes is required for transcript level normalization under different conditions in P. vera. In the present study, we selected eight widely used reference genes, ACT, EF1α, α-TUB, β-TUB, GAPDH, CYP2, UBQ10, and 18S rRNA. Using qRT-PCR their expression was assessed in 54 different samples of three cultivars of P. vera. The samples were collected from different organs under various abiotic treatments (cold, drought, and salt) across three time points. Several statistical programs (geNorm, NormFinder, and BestKeeper) were applied to estimate the expression stability of candidate reference genes. Results obtained from the statistical analysis were then exposed to Rank aggregation package to generate a consensus gene rank. Based on our results, EF1α was found to be the superior reference gene in all samples under all abiotic treatments. In addition to EF1α, ACT and β-TUB were the second best reference genes for gene expression analysis in leaf and root. We recommended β-TUB as the second most stable gene for samples under the cold and drought treatments, while ACT holds the same position in samples analyzed under salt treatment. This report will benefit future research on the expression profiling of P. vera and other members of the Anacardiaceae family.

Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin

International Nuclear Information System (INIS)

Anjum, Sadiya; Gupta, Amlan; Sharma, Deepika; Gautam, Deepti; Bhan, Surya; Sharma, Anupama; Kapil, Arti; Gupta, Bhuvanesh

2016-01-01

This study is aimed at the development of a composite material for wound dressing containing nanosilver nanohydrogels (nSnH) along with Aloe vera and curcumin that promote antimicrobial nature, wound healing and infection control. Nanosliver nanohydrogels were synthesized by nanoemulsion polymerization of methacrylic acid (MAA) followed by subsequent crosslinking and silver reduction under irradiation. Both the polymerization and irradiation time had significant influence on the nanoparticle shape, size and its formation. Polyvinyl alcohol/polyethylene oxide/carboxymethyl cellulose matrix was used as gel system to blend with nSnH, A. vera, curcumin and coat it on the hydrolysed PET fabric to develop antimicrobial dressings. The cumulative release of silver from the dressing was found to be ~ 42% of the total loading after 48 h. The antimicrobial activity of the dressings was studied against both Staphylococcus aureus and Escherichia coli. In vivo wound healing studies were carried out over a period of 16 d on full-thickness skin wounds created on Swiss albino mice. Fast healing was observed in Gel/nSnH/Aloe treated wounds with minimum scarring, as compared to other groups. The histological studies showed A. vera based dressings to be the most optimum one. These results suggest that nSnH along with A. vera based dressing material could be promising candidates for wound dressings. - Highlights: • PMAA based nanosilver nanogels offer excellent antimicrobial property. • nSnH may be coated on a fabric surface to develop wound care dressings. • Dressings show good wound recovery on animal models. • Aloe vera shows better healing behaviour as compared to the curcumin based systems.

Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera

Directory of Open Access Journals (Sweden)

Rue KS

2012-10-01

Full Text Available Kelly S Rue, Louis K Hirsch, Alfredo A SadunDepartment of Neuro-Ophthalmology, Doheny Eye Institute and Keck School of Medicine, University of Southern California, Los Angeles, CA, USAAbstract: We describe the course and likely pathophysiology of impending anterior ischemic optic neuropathy (AION and retinal vein occlusion in a 56-year-old man with polycythemia vera managed with interferon alpha for 2 years. Our patient presented with decreased vision, scintillating scotomata, and floaters. Fundus examination findings and results of a fluorescein angiogram led to the diagnosis of impending AION and retinal vein occlusion. Considering that both polycythemia vera and interferon have possible influences on vascular occlusion and optic disc edema, we stopped interferon treatment and immediately attempted to treat the polycythemia vera empirically with pentoxifylline and any interferon-associated inflammation with prednisone. Our patient experienced complete resolution of fundus abnormalities and return of normal vision within 3 weeks, which may be attributed to our successful treatment of both etiologies. Thus, further study is warranted to elucidate the treatment of both polycythemia vera and interferon-induced impending AION.Keywords: optic disc edema, interferon alpha, vascular occlusion, Roth spot, autoantibody, pentoxifylline

Formulation and evaluation of sustained release matrix tablets of pioglitazone hydrochloride using processed Aloe vera mucilage as release modifier

Directory of Open Access Journals (Sweden)

Manoj Choudhary

2015-01-01

Full Text Available Background: Natural gums and mucilage which hydrates and swells on contact with aqueous media are used as additives in the formulation of hydrophilic drug delivery system. Aim: The purpose of this study was to develop a new monolithic matrix system for complete delivery of Pioglitazone hydrochloride (HCl, in a zero-order manner over an extended time period using processed Aloe vera gel mucilage (PAG as a release modifier. Materials and Methods: The matrices were prepared by dry blending of selected ratios of polymer and ingredients using direct compression technique. Physicochemical properties of dried powdered mucilage of A. vera were studied. Various formulations of pioglitazone HCl and A. vera mucilage were prepared using different drug: Polymer ratios viz., 1:1, 1:2, 1:3, 1:4, 1:5 for PAG by direct compression technique. Results: The formulated matrix tablets were found to have better uniformity of weight and drug content with low statistical deviation. The swelling behavior and in vitro release rate characteristics were also studied. Conclusion: The study proved that the dried A. vera mucilage can be used as a matrix forming material for controlled release of Pioglitazone HCl matrix tablets.

Mice lacking the UbCKmit isoform of creatine kinase reveal slower spatial learning acquisition, diminished exploration and habituation, and reduced acoustic startle reflex responses.

NARCIS (Netherlands)

Streijger, F.; Jost, C.R.; Oerlemans, F.T.J.J.; Ellenbroek, B.A.; Cools, A.R.; Wieringa, B.; Zee, C.E.E.M. van der

2004-01-01

Brain-type creatine kinases B-CK (cytosolic) and UbCKmit (mitochondrial) are considered important for the maintenance and distribution of cellular energy in the central nervous system. Previously, we have demonstrated an abnormal behavioral phenotype in mice lacking the B-CK creatine kinase isoform,

Facile one step synthesis of novel TiO2 nanocoral by sol-gel method using Aloe vera plant extract

Science.gov (United States)

Venkatesh, K. S.; Krishnamoorthi, S. R.; Palani, N. S.; Thirumal, V.; Jose, Sujin P.; Wang, Fu-Ming; Ilangovan, R.

2015-05-01

Titanium oxide (TiO2) nanoparticles (NPs) were synthesized by sol gel method using Aloe vera plant extract as a biological capping agent and a cauliflower-nanocoral morphology was observed in this technique. The assynthesized TiO2 nanopowder was calcined at a range of temperatures (300-600 °C) for 1 h. The influence of A. vera plant extract on the thermal, structural and morphological properties of TiO2 nanopowder was evaluated. Thermogravimetric analysis/differential thermal analysis was employed to study the thermal properties of the assynthesized TiO2 nanopowder. The crystallinity, phase transformation and the crystallite size of the calcined samples were studied by X-ray diffraction technique. XRD result confirmed the presence of TiO2 with anatase phase. FT Raman spectra showed the Raman active modes pertaining to the TiO2 anatase phase and Raman band shift was also observed with respect to particle size variation. The different functional group vibrations of as dried pure A. vera plant extract were compared with the mixture of TiO2 and A. vera plant extract by FT-IR analysis. The scanning electron microscopy images apparently showed the formation of spherical shaped NPs and also it demonstrated the effect of A. vera plant extract on the reduction of particles size. The surface area of the TiO2 NPs was measured through Brunauer-Emmett-Teller analysis. Transmission electron microscopy images ascertained that the spherical shaped TiO2 NPs were formed with cauliflower-nanocoral morphology decorated with nanopolyps with the size range between 15 and 30 nm.

Preliminary Antiplaque Efficacy of Aloe Vera Mouthwash on 4 Day ...

African Journals Online (AJOL)

Background: Due to increasing resistance to antibiotics and rising incidence of oral diseases, there is a need for alternative treatment modalities to combat oral diseases. The aim of the present study was to access the effect of Aloe vera mouthwash on the dental plaque in the experimental period of 4 days and to compare it ...

Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f.

Science.gov (United States)

Kumar, Sandeep; Yadav, Amita; Yadav, Manila; Yadav, Jaya Parkash

2017-01-25

The aim of the present study was to analyse the effect of climate change on phytochemicals, total phenolic content (TPC) and antioxidant potential of methanolic extracts of Aloe vera collected from different climatic zones of the India. Crude methanolic extracts of A. vera from the different states of India were screened for presence of various phytochemicals, total phenolic content and in vitro antioxidant activity. Total phenolic content was tested by Folin-Ciocalteau reagent based assay whilst DPPH free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay, reducing power assay and β carotene-linoleic assay were used to assess the antioxidant potential of A. vera methanolic leaf extracts. Alkaloids, phenols, flavonoids, saponins, and terpenes were the main phytochemicals presents in all accessions. A significant positive correlation was found between TPC and antioxidant activity of different accessions. Extracts of highland and semi-arid zones possessed maximum antioxidant potential. Accessions from tropical zones showed the least antioxidant activity in all assays. It could be concluded that different agro-climatic conditions have effects on the phytochemicals, total phenolic content (TPC) and antioxidant potential of the A. vera plant. The results reveal that A. vera can be a potential source of novel natural antioxidant compounds.

Effectiveness of Aloe vera leaf extract against low level exposure to gamma radiation induced injury in intestinal mucosa of Swiss mice

International Nuclear Information System (INIS)

Gehlot, Prashasnika; Saini, M.R.

2004-01-01

Full Text: Human beings can not deny the presence of all sorts of incoming radiations, which are detrimental to life. The small intestine represents one of the major dose limiting normal tissues in radiotherapy because of its high radio sensitivity. The purpose of this study was to determine the effects of Aloe vera, a potential radioprotector. Radioprotective efficacy of aloe vera leaf extract in intestinal mucosa in mice (1 g/kg body weight/day) was studied from 6h to day 20 after gamma irradiation (0.5 Gy(. Villus height, goblet cells/villus section, total cells are good parameters for the assessment of radiation damage. The mice selected from inbreed colony were divided into two groups. The first group was given Aloe vera extract orally for 15 consecutive days and served as experimental group. On 15th day, after 30 min of above treatment animals of both the groups were exposed to 0.5 Gy gamma irradiation and autopsied on 6, 12, 24 h and 5, 10, 20 days. Aloe vera pretreatment resulted in a significant increase (p<0.001) in villus height, total cells whereas globlet cells showed a significant decrease (p<0.001) from respective irradiated controls at each autospy day. The results suggest that Aloe vera pretreatment provides protection against radiation-induced alterations in intestinal mucosa of Swiss mice

Cloning Protocol of Aloe vera as a Study-Case for “Tailor-Made” Biotechnology to Small Farmers

Directory of Open Access Journals (Sweden)

LH. Campestrini

2006-12-01

Full Text Available Aloe vera has been used worldwide both for pharmaceutical, food, and cosmetic industries due to the plethora of biological activities of some of its metabolites. A study case is reported focusing on the development of a cloning protocol of A. vera to provide propagation material with superior quality to the private sector in southern Brazil, i.e., A. vera juice industry. Such biotechnological approach afforded ca. 4,300 plantlets from 20 explants, over a 6-month period, overcoming the drawback of the lack of propagation material. Typically, the results have led to the increase of the cultured area and juice production of that species coming true the goal of the partnership between the public and private sectors herein involved. The transference of the resulting technology was successfully performed to the company and a patent covering the biotechnological process has been recently requested to official organisms on behalf of the partners.

Radioprotective effects of Aloe vera leaf extract on skin of Swiss mice after gamma irradiation

International Nuclear Information System (INIS)

Gehlot, Prashasnika; Saini, M.R.

2004-01-01

Full text: Biological effects of radiation are detrimental to life. Skin being a cell-renewal system is one of the best organ for studying radiation induced effects and their modulation by antioxidants. An attempt has been made to evaluate radioprotective efficacy of Aloe vera leaf extract on skin in Swiss mice (1g/kg body wt/day). The mice selected from inbreed colony were divided into two groups. The first group was given Aloe vera extract orally for 15th consecutive days and served as experimental group while the other group received DDW (vol. equal to Aloe extract) to serve as control group. On the 15th day, after 30 min of above treatment animals of both the groups were exposed to 2 Gy gamma irradiation and autopsied on 6h 1, 3, 7, 14 and 21 days. DNA as well as total protein decreases in control group as compared to the normal value. Surprisingly, in experimental group, DNA and protein increases in comparison to the control group. Thus, Aloe vera were found to have positive influence against radiation induced alterations on skin of Swiss albino mice

Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats.

Science.gov (United States)

Eamlamnam, Kallaya; Patumraj, Suthiluk; Visedopas, Naruemon; Thong-Ngam, Duangporn

2006-04-07

To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing. Male Spraque-Dawley rats (n=48) were divided into four groups. Group1 served as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera. The rats from each group were divided into 2 subgroups for study of leukocyte adherence, TNF-alpha and IL-10 levels and gastric ulcer healing on days 1 and 8 after induction of gastric ulcer by 20% acetic acid. On day 1 after induction of gastric ulcer, the leukocyte adherence in postcapillary venule was significantly (P<0.05) increased in the ulcer groups when compared to the control group. The level of TNF-alpha was elevated and the level of IL-10 was reduced. In the ulcer groups treated with sucralfate and Aloe vera, leukocyte adherence was reduced in postcapillary venule. The level of IL-10 was elevated, but the level of TNF-alpha had no significant difference. On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-alpha were still increased and the level of IL-10 was reduced in the ulcer group without treatment. The ulcer treated with sucralfate and Aloe vera had lower leukocyte adherence in postcapillary venule and TNF-alpha level. The level of IL-10 was still elevated compared to the ulcer group without treatment. Furthermore, histopathological examination of stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated. The ulcer sizes were also reduced compared to the ulcer group without treatment. Administration of 20% acetic acid can induce gastric inflammation, increase leukocyte adherence in postcapillary venule and TNF-alpha level and reduce

Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats

Institute of Scientific and Technical Information of China (English)

Kallaya Eamlamnam; Suthiluk Patumraj; Naruemon Visedopas; Duangporn Thong-Ngam

2006-01-01

AIM: To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing.METHODS: Male Spraque-Dawley rats (n=48) were divided into four groups. Group1 served as control group,group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera. The rats from each group were divided into 2 subgroups for study of leukocyte adherence, TNF-α and IL-10 levels and gastric ulcer healing on days 1 and 8 after induction of gastric ulcer by 20% acetic acid. RESULTS: On day 1 after induction of gastric ulcer, the leukocyte adherence in postcapillary venule was significantly (P＜ 0.05) increased in the ulcer groups when compared to the control group. The level of TNF-αwas elevated and the level of IL-10 was reduced. In the ulcer groups treated with sucralfate and Aloe vera,leukocyte adherence was reduced in postcapillary venule.The level of IL-10 was elevated, but the level of TNF-αhad no significant difference. On day 8, the leukocyte adherence in postcapillary venule and the level of TNF-αwere still increased and the level of IL-10 was reduced in the ulcer group without treatment. The ulcer treated with sucralfate and Aloe vera had lower leukocyte adherence in postcapillary venule and TNF-α level. The level of IL-10 was still elevated compared to the ulcer group without treatment. Furthermore, histopathological examination of stomach on days 1 and 8 after induction of gastric ulcer showed that gastric tissue was damaged with inflammation. In the ulcer groups treated with sucralfate and Aloe vera on days 1 and 8, gastric inflammation was reduced, epithelial cell proliferation was enhanced and gastric glands became elongated. The ulcer sizes were also reduced compared to the ulcer group without treatment.CONCLUSION: Administration of 20% acetic acid can induce gastric inflammation, increase leukocyte adherence in postcapillary venule and TNF-α level

Utilization of plant bioactives as feed additives for poultry: The effect of Aloe vera gel and its extract on performance of broilers

Directory of Open Access Journals (Sweden)

A.P Sinurat

2003-10-01

Full Text Available Feed additives are commonly added in poultry feed as a growth promotant or to improve feed efficiency. The most common feed additive used is antibiotic at sub-therapheutic doses, although there is a controversy on its impact on human health. Previous results showed that Aloe vera gel could improve feed efficiency in broilers and an in vitro study showed that the extract have an antibacterial effect. Therefore, a further experiment was designed to study the response of broilers to Aloe vera gel or its extract as feed additives. Aloe vera was prepared in dry gel or chloroform-extract and included in the diet at levels of 0.25; 0.50 and 1.00 g/kg (equal to dry gel. Standard diets with or without antibiotic were also formulated as control and a commercial diet was included for comparison. The diets were fed to broilers from day old to 5 weeks. Each treatment has 9 replicates and 6chicks/replicate. Parameters observed were: feed consumption, weight gain and feed convertion ratios. Carcass yield, abdominal fat levels, relative weight of liver, gizzard, tractus digestivus and length of tractus digestivus were also measured at the end of feeding trial. The results showed that Aloe gel and its extract did not influence body weight gain and feed consumption of broilers significantly (P>0.05, but improved feed convertion slightly (3.50%. The response in this trial was similar as thosecommercial diet and diet added with antibiotic. There was no significant (P>0.05 effect of Aloe vera bioactives on carcass yield, abdominal fat level and relative weight of liver. However, Aloe vera gel and its extract tend to increase gizzard weight, gastro intestinal weight and length. The Aloe vera gel and its extract also reduced the total count of aerobic bacteria in the digesta of tractus digestivus. It is concluded that the Aloe vera gel improve feed efficiency in broilers by increasing the size of tractus digestivus and reducing the total count of aerobic bacteria in

Efectividad del gel de aloe vera en pacientes con piodermitis subagudas

Directory of Open Access Journals (Sweden)

Arely Díaz Cifuentes

2015-06-01

Full Text Available Introducción: las piodermitis constituyen enfermedades cutáneas de origen bacteriano, catalogadas como enfermedades emergentes ya que se considera tienen carácter epidémico. Estas infecciones en la piel representan un motivo significativo de asistencia a las consultas dermatológicas. Su tratamiento es diverso, con antibióticos y crema de uso tópico, pero también puede ser utilizada el aloe vera en las lesiones, fundamentalmente por el poder emoliente suavizante que ejerce. Objetivo: determinar la efectividad del gel de aloe vera (Sábila en las piodermitis sub agudas, en pacientes que acudieron a la consulta de dermatología del consultorio “El Golfito” en el municipio de Cabimas, Venezuela, en el periodo comprendido entre 1 de enero hasta el 31 de diciembre de 2013. Métodos: se realizó un estudio experimental, exploratorio, correlacional, para determinar la efectividad del gel de aloe vera en las piodermitis sub agudas, en los pacientes, lugar y periodo de tiempo declarados. El universo de estudio estuvo constituido por 150 pacientes que asistieron a la referida consulta, diagnosticados clínicamente con esta entidad; la muestra quedó conformada por 50 pacientes, de ambos sexos y menores de 70 años. Se indicó tratamiento con antibiótico oral, amoxicillina en dosis de 50mg/kg al día dividida en tres dosis (cada 8 horas en niños hasta 15 años, a partir de esta edad la dosis fue de 500 mg cada 8 horas por 7 días y el uso tópico del gel del aloe en las lesiones tres veces al día hasta lograr la curación. Resultados: el grupo de edad más afectado estuvo en los menores de diecinueve años (42%; en las condiciones socioeconómicas de las familias e higiénico sanitaria de las viviendas predominaron las evaluadas de regular (74% - 70%. Las lesiones elementales más frecuentes al inicio fueron las exulceraciones (86%, mientras que a los 7 y 15 días predominan las máculas (82% - 96%. Se logra la curación en el 82% de los

Aloe vera Leaf Anti Inflamation’s Activity Speeds Up the Healing Proccess of Oral Mucosa Ulceration

Directory of Open Access Journals (Sweden)

Agoeng Tjahajani

2013-05-01

Full Text Available Previous work showed that 25% of inner layer Aloe vera leaf extract was effective as anti-inflammatory on the oral mucous of Wistar rats. Objective: The aim of this study was to examine the lowest concentration of whole leaf Aloe vera extract that could accelerate healing process of ulceration on rats. Methods: Sixty inbreeding Spraque Dawley rats was exposed to solution of Hydrogen Peroxide 10% during three days to induced inflammation on the labial mucous inferior of rats. During the next three days, on the same area of control group were topically applied solution of Natrium Chloride 0.9%; while in the treatment group were topically applied 6.25%; 12.5%; 25% of whole leaf of Aloe vera extract for 3x5 minutes with 90 minutes intervals. On the fourth day, five rats in each group were sacrificed; and the same treatment was done on others groups. On the sixth day, five rats of each group were sacrificed; and the same treatment was done on the rest group up to seven days. On the eighth days, the rest groups were sacrificed. Microscopic slides were done. Results: Microscopic slides were analyzed under light microscope and scored. Statistical analysis with Mann-Whitney test showed significant differences between control and treatment group (p<0.05. Conclusion: Application of 6.25% whole leaf Aloe vera extract was the lowest and the most effective concentration in accelerating the healing process of oral mucous ulceration on rats.DOI: 10.14693/jdi.v18i1.56

In vitro activity of Allium sativum and Aloe vera extract against ...

African Journals Online (AJOL)

The rapid increase of antibiotic resistance needs to be taken as a threat to both animals and human being. In this study the arbitrary concentration of 25%, 50% and 75% of individual and combined Allium sativum and Aloe vera were tested against Salmonella Gallinarum. The antimicrobials were extracted using aqueous ...

Role of Natural Immunomodulator (Aloe Vera in Cellular and Humoral Immune Responses

Directory of Open Access Journals (Sweden)

Ening Wiedosari

2007-12-01

Full Text Available Aloe vera belongs to a group of Liliaceae family plant and cultivated worldwide. It possesses acemannan (acetylated mannan, which has a significant pharmacological property. The acemannan has an immunomodulatory activity when administered to animals. The major immunomodulating effect includes the activation of immune effector cells, such as lymphocytes and macrophages, resulting in the production of cytokines, interleukin (IL-1, IL-6, IL-12 and tumor necrosis factor alpha (TNFα. In particular, this extract can modulate the differentiation capacity of CD4+T cells to mature into Th1 subsets and enhance the innate cytokine response. As a consequence, this extract will have a profound effect in controlling disease, caused by intracellular infectious agents (bacteria and viruses. However, further studies are needed to determine the immunomodulating effects of Aloe vera in multi-component extracts equivalent to what are being used commonly in traditional medicine.

Use and risks of phosphorus-32 in the treatment of polycythaemia vera

Energy Technology Data Exchange (ETDEWEB)

Parmentier, Claude [UPRES EA No. 27-10 and Nuclear Medicine Department, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805, Villejuif (France)

2003-10-01

The risk of development of cancer, and more specifically acute leukaemia, after use of phosphorus-32 in patients with polycythaemia vera has been recognised for approximately 40 years. As a consequence of this risk, the indications for, and contraindications to, {sup 32}P are unclear in the physician's mind. This paper aims to clarify the problem. The relation between polycythaemia vera and leukaemia is explored and the question of whether chemotherapy represents an alternative to {sup 32}P is discussed. From the results obtained to date, two clear conclusions can be drawn: First, whatever the age of the patient, phlebotomy must be used to avoid the menace of vascular complications before the institution of basic treatment, but it cannot be used as the sole form of treatment. Second, {sup 32}P treatment retains an important role at least when chemotherapy fails and in elderly patients (>70 years). (orig.)

Polycythemia vera presenting with left hemichoreiform movements

International Nuclear Information System (INIS)

Mori, Tamiharu; Shimomura, Chikako; Ishibashi, Hiroshi; Tsujihata, Mitsuhiro; Nagataki, Shigenobu.

1985-01-01

A 65-year-old man developed abruptly choreiform movements involving the left face, arm and leg one day prior to admission. Physical examination revealed red face and palms, hyperemic conjunctivae and atrial fibrillations. Blood pressure was 168/90. Spleen was not palpable. Hemichoreiform movements of the left face and limbs were observed. There was no other neurological abnormalities. Laboratory studies showed RBC 880x10 4 , Hb 22.4g/dl, Hct 63%, WBC 8,100, platelets 22.9x10 4 , ESR 0mm/hr, RBC oxygen saturation 97%, serum iron 67 μg/dl, LDH 593 units, uric acid 14mg/dl, and erythropoietine (HI method) 19mIU/ml (normal 28-88). Bone marrow showed myeloid nucleated cell count 38.6x10 4 . ECG showed atrial fibrillations. Chest X-ray and scintigrams of liver and spleen were normal. CSF was normal. Brain CT scan on admission disclosed a low density area in right caudate nucleus. The choreiform movements were rapidly mitigated by venesection and by oral administration of haloperidol(3mg daily). There weeks after discontinuing haloperidol, the hemichorea returned. The routine hematology showed RBC 870x10 4 , Hb 19.8g/dl, Hct 62%, WBC 10,200, and plateret 37.4x10 4 . Another venesection reduced the chorea. Pipobroman was administered to control the polycythemia vera. He has been free of choreic movements thereafter. Choreiform movement is rarely observed in polycythemia vera. The pathogenesis is still unknown. The venous congestion, however, may play a role in this case because the choreic movements disappeared by venesection. (author)

Clinical and radiographic evaluation of zinc oxide with aloe vera as an obturating material in pulpectomy: An in vivo study

Directory of Open Access Journals (Sweden)

Abhishek Khairwa

2014-01-01

Full Text Available Background: Pulp therapy for pulpally involved primary teeth continues to be a challenge to clinicians. One of the major areas of continued research is in the area of finding obturating materials to suit the specific properties of these teeth. Zinc oxide eugenol is used frequently in pulpectomy for the obturation of the primary teeth. Aims: To evaluate clinically and radiographically a mixture of zinc oxide eugenol and aloe vera as an obturating material. Materials and Methods: A total of 50 children, aged between 4 and 9 years, who were screened for unilateral or bilateral carious deciduous molars were studied. Out of these, 15 children were randomly selected for endodontic treatment. Obturation was done with a mixture of zinc oxide powder and aloe vera gel. Clinical and radiographic evaluation was done after 7 days, 1 month, 3 months, 6 months, and 9 months. The data were statistically analyzed. Results and Conclusion: Endodontic treatment using a mixture of zinc oxide powder and aloe vera gel in primary teeth has shown good clinical and radiographic success. A detailed observational study with longer follow-up will highlight the benefits of aloe vera in primary teeth as an obturating medium.

The Effects of Aloe Vera on TNF-a Levels, the Percentage of Nk Cells and Th 17 Cells in Rat That Received Izoniazid and Rifampycin.

Science.gov (United States)

Mawarti, Herin; Rajin, Mukhamad; Asumta, Zulfikar

2017-10-01

The present study was undertaken to investigate the hepatoprotective effect of Aloe vera against side effect of antituberculosis drug. Twenty-five rats will be divided into five groups, namely the control group (without any treatment), the group of rats treated with anti-tuberculosis drugs, and a group of rats were treated antituberculosis drugs and got Aloe vera extract at a dose of 40; 80; and 120 mg/kg body weight. Antituberculosis drugs are isoniazid and rifampicin a dose of 50 mg/kg body weight. Antituberculosis treated group showed significantly increase levels of TNF-a, the percentage of NK cells and the number of Th17 cells compared with the control group ( p 0.05). Aloe vera at first and the third dose lower the number of NK cells compared to the antituberculosis group, although it has not yet reached a significant difference ( p > 0.05). The first dose of Aloe vera was significantly decreased the percentage of Th17 cells compared to the antituberculosis drug group ( p 0.05). It was concluded that administration of Aloe vera can suppress the production of TNF-a and the percentage of Th17 cells as a result of antituberculosis drug administration. Thus, Aloe vera can be a useful alternative to natural materials in the successful treatment of tuberculosis through the inhibition of side effect.

Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin.

Science.gov (United States)

Anjum, Sadiya; Gupta, Amlan; Sharma, Deepika; Gautam, Deepti; Bhan, Surya; Sharma, Anupama; Kapil, Arti; Gupta, Bhuvanesh

2016-07-01

This study is aimed at the development of a composite material for wound dressing containing nanosilver nanohydrogels (nSnH) along with Aloe vera and curcumin that promote antimicrobial nature, wound healing and infection control. Nanosliver nanohydrogels were synthesized by nanoemulsion polymerization of methacrylic acid (MAA) followed by subsequent crosslinking and silver reduction under irradiation. Both the polymerization and irradiation time had significant influence on the nanoparticle shape, size and its formation. Polyvinyl alcohol/polyethylene oxide/carboxymethyl cellulose matrix was used as gel system to blend with nSnH, A. vera, curcumin and coat it on the hydrolysed PET fabric to develop antimicrobial dressings. The cumulative release of silver from the dressing was found to be ~42% of the total loading after 48h. The antimicrobial activity of the dressings was studied against both Staphylococcus aureus and Escherichia coli. In vivo wound healing studies were carried out over a period of 16d on full-thickness skin wounds created on Swiss albino mice. Fast healing was observed in Gel/nSnH/Aloe treated wounds with minimum scarring, as compared to other groups. The histological studies showed A. vera based dressings to be the most optimum one. These results suggest that nSnH along with A. vera based dressing material could be promising candidates for wound dressings. Copyright © 2016 Elsevier B.V. All rights reserved.

Skin permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox.

Science.gov (United States)

Fox, Lizelle T; Gerber, Minja; du Preez, Jan L; du Plessis, Jeanetta; Hamman, Josias H

2015-01-01

The aim of this study was to investigate the in-vitro permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox using ketoprofen as a marker compound. The permeation studies were conducted across excised female abdominal skin in Franz diffusion cells, and the delivery of ketoprofen into the stratum corneum-epidermis and epidermis-dermis layers of the skin was investigated using a tape-stripping technique. A. vera gel showed the highest permeation-enhancing effect on ketoprofen (enhancement ratio or ER = 2.551) when compared with the control group, followed by A. marlothii gel (ER = 1.590) and A. ferox whole-leaf material (ER = 1.520). Non-linear curve fitting calculations indicated that the drug permeation-enhancing effect of A. vera gel can be attributed to an increased partitioning of the drug into the skin, while A. ferox whole leaf modified the diffusion characteristics of the skin for ketoprofen. The tape stripping results indicated that A. marlothii whole leaf delivered the highest concentration of the ketoprofen into the different skin layers. Of the selected aloe species investigated, A. vera gel material showed the highest potential as transdermal drug penetration enhancer across human skin. © 2014 Royal Pharmaceutical Society.

Maser observation in VY CMa with VERA

Science.gov (United States)

Choi, Yoon Kyung

We present the results of multi-epoch VERA (VLBI Exploration of Radio Astrometry) observations of H2O masers at 22 GHz and ^28SiO masers at 43 GHz in the supergiant VY Canis Majoris (hereafter, VY CMa). We estimate the inner motion of H2O masers over 6 months and that of SiO masers over 1 month. Using the inner motion, we calculated the statistical parallax of VY CMa. The size of the emitting region for ^28SiO masers is R_SiO ~1.81-2.89 R_* and it is consistent with the previous study.

Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features.

Science.gov (United States)

Jambal, Purevsuren; Badtke, Melanie M; Harrell, J Chuck; Borges, Virginia F; Post, Miriam D; Sollender, Grace E; Spillman, Monique A; Horwitz, Kathryn B; Jacobsen, Britta M

2013-01-01

Mucinous breast cancer (MBC) is mainly a disease of postmenopausal women. Pure MBC is rare and augurs a good prognosis. In contrast, MBC mixed with other histological subtypes of invasive disease loses the more favorable prognosis. Because of the relative rarity of pure MBC, little is known about its cell and tumor biology and relationship to invasive disease of other subtypes. We have now developed a human breast cancer cell line called BCK4, in which we can control the behavior of MBC. BCK4 cells were derived from a patient whose poorly differentiated primary tumor was treated with chemotherapy, radiation and tamoxifen. Malignant cells from a recurrent pleural effusion were xenografted in mammary glands of a nude mouse. Cells from the solid tumor xenograft were propagated in culture to generate the BCK4 cell line. Multiple marker and chromosome analyses demonstrate that BCK4 cells are human, near diploid and luminal, expressing functional estrogen, androgen, and progesterone receptors. When xenografted back into immunocompromised cycling mice, BCK4 cells grow into small pure MBC. However, if mice are supplemented with continuous estradiol, tumors switch to invasive lobular carcinoma (ILC) with mucinous features (mixed MBC), and growth is markedly accelerated. Tamoxifen prevents the expansion of this more invasive component. The unexpected ability of estrogens to convert pure MBC into mixed MBC with ILC may explain the rarity of the pure disease in premenopausal women. These studies show that MBC can be derived from lobular precursors and that BCK4 cells are new, unique models to study the phenotypic plasticity, hormonal regulation, optimal therapeutic interventions, and metastatic patterns of MBC.

Impedance studies of a green blend polymer electrolyte based on PVA and Aloe-vera

Science.gov (United States)

Selvalakshmi, S.; Mathavan, T.; Vijaya, N.; Selvasekarapandian, Premalatha, M.; Monisha, S.

2016-05-01

The development of polymer electrolyte materials for energy generating and energy storage devices is a challenge today. A new type of blended green electrolyte based on Poly-vinyl alcohol (PVA) and Aloe-vera has been prepared by solution casting technique. The blending of polymers may lead to the increase in stability due to one polymer portraying itself as a mechanical stiffener and the other as a gelled matrix supported by the other. The prepared blend electrolytes were subjected to Ac impedance studies. It has been found out that the polymer film in which 1 gm of PVA was dissolved in 40 ml of Aloe-vera extract exhibits highest conductivity and its value is 3.08 × 10-4 S cm-1.

Assessment of the safety of aqueous extract of Aloe vera on ...

African Journals Online (AJOL)

Aghomotsegin

2015-07-29

Jul 29, 2015 ... Aloe vera is used both traditionally and packaged commercially in many regions of the world for several medicinal and or cosmetic purposes. It is claimed to have rejuvenating, moisturizing, healing or soothing properties on the skin and gastrointestinal tract. This study focused on assessment of the safety of ...

Expression of biologically active human interferon alpha 2 in aloe vera

Science.gov (United States)

We have developed a system for transgenic expression of proteins in Aloe Vera. Using this approach we have generated plants expressing the human gene interferon alpha 2, IFNa2. IFNa2 is a small secreted cytokine that plays a vital role in regulating the body’s immune response to viral infections a...

Efficacy of Aloe Vera Supplementation on Prediabetes and Early Non-Treated Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Science.gov (United States)

Zhang, Yiyi; Liu, Wen; Liu, Dan; Zhao, Tieyun; Tian, Haoming

2016-06-23

The aim of this study was to evaluate evidence for the efficacy of aloe vera on managing prediabetes and early non-treated diabetes mellitus. We performed a systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials until 28 January 2016. A total of five randomized controlled trials (RCTs) involving 415 participants were included. Compared with the controls, aloe vera supplementation significantly reduced the concentrations of fasting blood glucose (FBG) (p = 0.02; weighed mean difference [WMD]: -30.05 mg/dL; 95% confidence interval [CI]: -54.87 to -5.23 mg/dL), glycosylated hemoglobin A1c (HbA1c) (p Aloe vera was superior to placebo in increasing serum high density lipoprotein-cholesterol (HDL-C) levels (p = 0.04). Only one adverse event was reported. The evidence from RCTs showed that aloe vera might effectively reduce the levels of FBG, HbA1c, triglyceride, TC and LDL-C, and increase the levels of HDL-C on prediabetes and early non-treated diabetic patients. Limited evidence exists about the safety of aloe vera. Given the small number and poor quality of RCTs included in the meta-analysis, these results are inconclusive. A large-scale, well-designed RCT is needed to further address this issue.

Antibacterial effect of triantibiotic mixture, chlorhexidine gel, and two natural materials Propolis and Aloe vera against Enterococcus faecalis: An ex vivo study

Directory of Open Access Journals (Sweden)

Leila Bazvand

2014-01-01

Full Text Available Background: The aim of this ex vivo study was to compare the antimicrobial effect of triantibiotic paste, 0.2% chlorhexidine gel, Propolis and Aloe vera on Enterococcus faecalis in deep dentin. Materials and Methods: Ninety fresh extracted single-rooted teeth were used in a dentin block model. Seventy-five teeth were infected with E. faecalis and divided into four experimental groups (n = 15. Experimental groups were treated with triantibiotic mixture with distilled water, 0.2% chlorhexidine gel, 70% ethanol + Propolis and Aloe vera. Fifteen teeth treated with distilled water as the positive control and 15 samples, free of bacterial contamination, were considered as the negative control. Gates-Glidden drill #4 was used for removal of surface dentin and Gates-Glidden drill #5 was used to collect samples of deep dentin. The samples were prepared and colony-forming units were counted. Data were analyzed by one-way ANOVA and post hoc Tukey tests. Statistical significance was defined at P 0.05. Aloe vera had antibacterial effects on E. faecalis, but in comparison with other medicaments, it was less effective (P < 0.05. Conclusion: This experimental study showed that triantibiotic mixture, 0.2% chlorhexidine gel, Propolis and Aleo vera were relatively effective against E. faecalis. All the intracanal medicements had similar effects on E. faecalis in deep dentin except for Aloe vera.

Effects of Aloe Vera and Chitosan Nanoparticle Thin-Film Membranes on Wound Healing in Full Thickness Infected Wounds with Methicillin Resistant Staphylococcus Aureus.

Science.gov (United States)

Ranjbar, Reza; Yousefi, Alireza

2018-01-01

To assess effect of Aleo vera with chitosan nanoparticle biofilm on wound healing in full thickness infected wounds with antibiotic resistant gram positive bacteria. Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9% saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle thin-film membranes. Group IV: Animals with infected wounds were treated topically with Aloe vera and Group V: Animals with infected wounds were treated topically with Aloe vera and dressed with chitosan nanoparticle thin-film membranes. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery. Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference ( p vera with chitosan nanoparticle thin-film membranes had a reproducible wound healing potential and hereby justified its use in practice.

Dye-sensitized solar cells using Aloe Vera and Cladode of Cactus extracts as natural sensitizers

Science.gov (United States)

Ganta, D.; Jara, J.; Villanueva, R.

2017-07-01

The purpose of this study is to develop dye-sensitized solar cells (DSSCs) from natural plant-based dyes, extracted from the Cladode (nopal) of the Thornless Prickly Pear Cactus (Opuntia ficus-indica), the gel of Aloe Vera (Aloe barbadensis miller), and the combination of Cladode and Aloe Vera extracts on side-by-side configuration. Optical properties were analyzed using UV-Vis Absorption and Fourier Transform Infrared Spectroscopy. Open circuit voltages (Voc) varied from 0.440 to 0.676 V, fill factors (FF) were greater than 40%, short-circuit photocurrent densities (Jsc) ranged from 0.112 to 0.290 mA/cm2 and highest conversion efficiency of 0.740% was reported for the Cladode DSSC.

Modulatory influence of Aloe vera against radiation and cadmium induced hepatic lesions in Swiss albino mice

International Nuclear Information System (INIS)

Harsha, Radha; Purohit, R.K.

2012-01-01

The major objectives in radiobiology has been the development of agents that can mitigate the damage produced by ionizing radiation to normal tissues and thus reduces the side effects caused by radiation and improvement of cancer radiotherapy. The various agents have drawn attention of researchers as they provide wider acceptability and least side effects. The current study was aimed to investigate the protective effect of Aloe vera against radiation and cadmium induced changes in the liver of Swiss albino mice. For the study healthy male Swiss albino mice (6 to 8 weeks old) were selected from an inbred colony and kept in polypropylene cages. They were provided with standard mice feed and tap water ad libitum. The animals were exposed to 3.0 and 6.0 Gy of gamma radiation with or without cadmium chloride treatment. The animals of experimental groups were administered Aloe vera juice seven days prior to irradiation or cadmium chloride treatment. The animals of each group were autopsied at each post treatment interval of 1, 2, 4, 7, 14 and 28 days of treatment. The various biochemical parameters estimated were total proteins, glycogen, cholesterol, acid and alkaline phosphatase activities, DNA and RNA. After routine procedure, histopathological changes were also observed. The changes in various biochemical parameters were observed in the form of increase of decrease in values. The histopathological changes observed on day-1 after exposure to 3.0 Gy were distortion of hepatic architecture, intracellular oedema, narrower sinusoids, cytoplasmic degranulation, vacuolation and pycnotic nuclei. The changes were more marked on day-4 and continued up to day-14. But on day-28 the sign of recovery was observed. After exposure to a higher dose (6.0 Gy) similar changes were noticed but they were more pronounced and there was late manifestation of recovery. In the combined treatment of radiation and cadmium chloride synergistic effects were observed. The liver of Aloe vera treated

Preventive action of Aloe vera against radiation and cadmium induced haematological changes in Swiss albino mice

International Nuclear Information System (INIS)

Agarwal, Manisha; Purohit, R.K.; Chakrawarti, Aruna; Bhartiya, K.M.

2012-01-01

Haematopoietic organs are markedly sensitive to ionizing radiation due to its proliferate activity. The changes found in the circulating blood are primarily due to damage in the radio sensitive haematopoeitic organs. A very small dose of radiation to a blood forming organ causes an arrest of haematopoiesis with changes in peripheral blood count. Certain trace elements are essential for normal growth and development of organisms but their concentration beyond threshold may produce damage to blood forming organs and tissues thus affecting the peripheral blood. Aloe vera has been claimed to contain several important therapeutic properties including anti cancer effects. Various studies showed the prevention of radiation induced suppression of immunity by Aloe vera components. Having these unique properties, Aloe vera could be used in clinical field as a protector against radiation and heavy metal toxicity in human beings. For the study, six to eight weeks old Swiss albino mice were procured and kept in polypropylene cages. The animals were fed with standard mice feed and water was provided to them ad libitum. Cadmium chloride was administered orally to the animals in drinking water at the dose rate of 20 ppm. The animals were exposed to sub lethal doses of 2.0 Gy and 4.0 Gy of gamma radiation from cobalt 60 source. The Aloe vera was given seven days prior to irradiation and continued up to last autopsy day in experimental animals. Five animals from each group were autopsied by cervical dislocation at each post treatment interval of 1,2,4,7,14 and 28 days. The differential leucocytes count was estimated by preparing smear of the blood. The value of lymphocyte decreased up to day-14 in non drug treated groups thereafter it increased up to day-28 whereas the count decreased up to day-7 in drug treated groups and showed an increasing trend at day-14 which continues up to day-28. The value of monocyte and granulocyte percentage increased up to day-7 in drug treated groups

Atributos biológicos y terapéuticos de la Sábila (Aloe vera | Biological and therapeutic attributes of Aloe (Aloe vera

Directory of Open Access Journals (Sweden)

José Imery Buzia

2017-11-01

Full Text Available Aloe, Aloe vera (L. Burm. f. (= A. barbadensis Miller is a monocotyledon, perennial, and succulent plant of the family Asphodelaceae, recognized worldwide for its medicinal properties and ornamental value. For the beauty of their vegetative structures, drought tolerance, popular beliefs and mysticism, Aloe has an important place in the house porches, gardens, terraces, and balconies of many Latin American households. Its healing potential has been supported by multiple laboratories, natural medicine and traditional hospitals that evaluate alternatives for healing of gastrointestinal, epidermal, cardiovascular, respiratory, metabolic, cancer, among other, which are reported to improve the rational management of extracts as a specific treatment to relieve some diseases or as an adjunct to the effects of formal medicine. This work presents a compendium of botanical studies by our research laboratory on local populations of A. vera and provide an update review on its taxonomy, phylogeny, components, and therapeutic uses. Specific anatomical details and morphological traits, evaluated under ambient conditions of tropical very dry forest of northeastern Venezuela, were described and scientific arguments about its origin, evolution and nomenclature were analyzed. This is a contribution to the comprehensive knowledge of this species, whose cultivation and agro-industrial use represents a possibility to improve the quality of life of coastal communities, diversification of local economies and the export of non-traditional products.

Las hermandades y cofradías de la Vera Cruz en el País Vasco

Directory of Open Access Journals (Sweden)

García Fernández, Ernesto

2009-12-01

Full Text Available In this paper we analyse the period in which the first foundations of the Brotherhoods and Fraternities of the True Cross took place in the Basque Country and assess the importance that the cult of the Cross had in this region. In addition, we examine carefully and systematically the evident relations between the fraternity of the True Cross in Bilbao and the fraternity of the True Cross in Vitoria, for whose foundation in 1538 there is documented evidence. This study shows that the statutes of the fraternity of the True Cross in the town of Vitoria were taken into account by those who decided to set up the same fraternity in the town of Bilbao in the middle of the sixteenth century.En este artículo se analiza y valora el período en que se produjeron en el País Vasco las primeras fundaciones de las Hermandades y Cofradías de la Vera Cruz, así como la importancia que tuvo el culto a la Cruz en este territorio. Al mismo tiempo se examinan, de manera más precisa y sistemática, las relaciones manifiestas de la cofradía de la Vera Cruz de Bilbao con la cofradía de la Vera Cruz de Vitoria, cuya fundación está documentada en 1538. De este estudio se deriva que los estatutos de la cofradía de la Vera Cruz de la ciudad de Vitoria fueron tenidos en cuenta por quienes en la villa de Bilbao decidieron instituir dicha cofradía a mediados del siglo XVI.

Comparative evaluation of effectiveness between Aloe vera and two commercially available mouth rinses on plaque and gingival status: A randomized control trial

Directory of Open Access Journals (Sweden)

Sujal Parkar

2011-01-01

Full Text Available Aim: Aloe vera has been suggested for a wide variety of ailments, but its use in dentistry is limited. The purpose of the study was to evaluate the effect of A. vera on the reduction of plaque and gingivitis. This effect was evaluated by randomized, parallel and double-blind clinical trial. Materials and Methods: Total 30 subjects were randomly allocated into three groups; 10 in each for (i chlorhexidine, (ii tea tree leaves and (iii A. vera. Plaque index and gingival index were assessed at days 0 and 21. Subjects were asked to rinse their mouth with the mouth rinse, twice a day, during a 21-day period. Paired t-test was used test the mean difference at 0 day and 21 days. One way analysis of variance was used to check the mean difference among three mouth rinses. Results: All three mouth rinses shows a significant reduction from 0 day to 21 days (P 0.05. Conclusion: A. vera mouth rinse was as effective as two commercially popular mouth rinses in controlling plaque and gingivitis.

Genetic and ecological outcomes of Inga vera subsp. affinis (Leguminosae) tree plantations in a fragmented tropical landscape.

Science.gov (United States)

Cruz Neto, Oswaldo; Aguiar, Antonio V; Twyford, Alex D; Neaves, Linda E; Pennington, R Toby; Lopes, Ariadna V

2014-01-01

Planting of native trees for habitat restoration is a widespread practice, but the consequences for the retention and transmission of genetic diversity in planted and natural populations are unclear. Using Inga vera subsp. affinis as a model species, we genotyped five natural and five planted populations in the Atlantic forest of northeastern Brazil at polymorphic microsatellite loci. We studied the breeding system and population structure to test how much genetic diversity is retained in planted relative to natural populations. We then genotyped seedlings from these populations to test whether genetic diversity in planted populations is restored by outcrossing to natural populations of I. vera. The breeding system of natural I. vera populations was confirmed to be highly outcrossing (t = 0.92; FIS = -0.061, P = 0.04), with populations showing weak population substructure (FST = 0.028). Genetic diversity in planted populations was 50% less than that of natural populations (planted: AR = 14.9, HO = 0.865 and natural: AR = 30.8, HO = 0.655). However, seedlings from planted populations showed a 30% higher allelic richness relative to their parents (seedlings AR = 10.5, parents AR = 7.6). Understanding the processes and interactions that shape this system are necessary to provide ecologically sensible goals and successfully restore hyper-fragmented habitats. Future restoration plans for I. vera must consider the genetic diversity of planted populations and the potential for gene flow between natural populations in the landscape, in order to preserve ecological interactions (i.e. pollination), and promote opportunities for outcrossing.

Reduction of Fasting Blood Glucose and Hemoglobin A1c Using Oral Aloe Vera: A Meta-Analysis.

Science.gov (United States)

Dick, William R; Fletcher, Emily A; Shah, Sachin A

2016-06-01

Diabetes mellitus is a global epidemic and one of the leading causes of morbidity and mortality. Additional medications that are novel, affordable, and efficacious are needed to treat this rampant disease. This meta-analysis was performed to ascertain the effectiveness of oral aloe vera consumption on the reduction of fasting blood glucose (FBG) and hemoglobin A1c (HbA1c). PubMed, CINAHL, Natural Medicines Comprehensive Database, and Natural Standard databases were searched. Studies of aloe vera's effect on FBG, HbA1c, homeostasis model assessment-estimated insulin resistance (HOMA-IR), fasting serum insulin, fructosamine, and oral glucose tolerance test (OGTT) in prediabetic and diabetic populations were examined. After data extraction, the parameters of FBG and HbA1c had appropriate data for meta-analyses. Extracted data were verified and then analyzed by StatsDirect Statistical Software. Reductions of FBG and HbA1c were reported as the weighted mean differences from baseline, calculated by a random-effects model with 95% confidence intervals. Subgroup analyses to determine clinical and statistical heterogeneity were also performed. Publication bias was assessed by using the Egger bias statistic. Nine studies were included in the FBG parameter (n = 283); 5 of these studies included HbA1c data (n = 89). Aloe vera decreased FBG by 46.6 mg/dL (p aloe vera for significantly reducing FBG (46.6 mg/dL) and HbA1c (1.05%). Further clinical studies that are more robust and better controlled are warranted to further explore these findings.

Effect of Edible Coatings from Aloe vera gel on Citrus sinensis ...

African Journals Online (AJOL)

Extension of the shelf life of orange fruits continues to be a challenge in Nigeria. The search for safe, healthy and environmental friendly treatments has led to increased interest in research into edible and biodegradable films and coatings. In this work, the use of Aloe vera gel as a coating to extend the shelf-life of orange ...

Not a scintilla of light: Darkness and despondency in Yvonne Vera's ...

African Journals Online (AJOL)

The paper makes an attempt at exploring the concept of the absurd as it applies to Yvonne Vera's Butterfly Burning. The inordinate quest for survival and human dignity is graphically etched on the sordid canvas of angst, grime and abject poverty. The author deftly links this quest with the quest of identity which is manifested ...

Eesti kirjandus Moskvas : ajutine vaikus : [intervjuu] / Vera Ruber, Aleksandr Tomberg ; üles kirjut. Triin Parts

Index Scriptorium Estoniae

Ruber, Vera, 1925-2011

1997-01-01

Emil Tode (T. Õnnepalu) 'Piiririik' ilmub Vera Ruberi tõlkes ajakirja 'Druzhba Narodov' detsembrinumbris. Aleksandr Tombergil on valmis romaani 'Hind' tõlge, kuid seni puuduvad avaldamisvõimalused

DNA Methylation as an Epigenetic Factor in the Development and Progression of Polycythemia Vera

National Research Council Canada - National Science Library

Issa, Jean-Pierre

2007-01-01

Polycythemia vera (PV) is the most common myeloproliferative disorder with a yearly incidence of 28 per 1 million people and a slightly higher prevalence in males PV is characterized by clonal expansion of erythroid...

Haemoglobinopathia Ypsilanti – A rare, but important differential diagnosis to polycythaemia vera

DEFF Research Database (Denmark)

Nygaard, Marietta; Petersen, Jesper; Bjerrum, Ole W

2013-01-01

We present a case of a mother and daughter who were initially diagnosed with polycythaemia vera and treated with venesectio. As JAK2 V6217F/exon 12 mutation analyses became available, these were performed and turned out negative. Haemoglobin electrophoresis was performed and the patients were fou...

Anti-staphylococcal properties of Eichhornia crassipes, Pistacia vera, and Ziziphus amole leaf extracts: Isolates from cattle and rabbits.

Science.gov (United States)

Gutiérrez-Morales, Andrea; Velázquez-Ordoñez, Valente; Khusro, Ameer; Salem, Abdelfattah Z M; Estrada-Zúñiga, María Elena; Salem, Mohamed Z M; Valladares-Carranza, Benjamin; Burrola-Aguilar, Cristina

2017-12-01

The desideratum aim of the present context was to assess the biopotency of methanolic extracts of Eichhornia crassipes (E. crassipes), Pistacia vera (P. vera), and Ziziphus amole (Z. amole) leaves against various staphylococcal strains, and to quantify the phenolics as well as saponin content in them. The antibacterial activity of various concentrations (62.5-1000 μg/mL) of plant extracts was tested against control clinical strains (Staphylococcus aureus ATCC 25923, S. aureus ATCC 29213, and S. aureus ATCC 43300), methicillin-resistant S. aureus (MRSA1 and MRSA2), oxacillin sensitive S. aureus (SOSA1 and SOSA2), and coagulase-negative Staphylococcus epidermidis (CoNS1, CoNS2, and CoNS3) using disc diffusion assay. Leaf extracts of the three plants exhibited pronounced growth inhibitory characteristics against staphylococci in a dose dependent manner. E. crassipes extract depicted the highest relative percentage inhibition values against control clinical strains (68.6 ± 0.5%), while P. vera (68.6 ± 0.3%) and Z. amole (74.79 ± 0.3%) extracts showed pronounced relative inhibition values against staphylococcal strains isolated from cattle. Total phenols and saponin content of leaf extracts were investigated by standard in vitro methods. The methanolic extracts of these plants were found to comprise substantial content of phenolics and saponin at varying levels. The highest value of phenolics was estimated in P. vera extract (60.0 ± 1.3 mg gallic acid/g extract), followed by Z. amole (33.6 ± 1.4 mg gallic acid/g extract), and E. crassipes (23.0 ± 1.3 mg gallic acid/g extract). Saponin content for P. vera, Z. amole, and E. crassipes extracts were estimated as 41.0 ± 1.3, 35.8 ± 1.3, and 25.0 ± 1.2 mg diosgenin/g extract, respectively. The outcome of this study suggested the exploitation of methanolic extract of P. vera, Z. amole, and E. crassipes leaves for their possible application in ethnomedicine, particularly as drugs preparation

A comparison of the leaf gel extracts of Aloe ferox and Aloe vera in the topical treatment of atopic dermatitis in Balb/c mice.

Science.gov (United States)

Finberg, M J; Muntingh, G L; van Rensburg, C E J

2015-12-01

Aloe vera gel is widely used in the treatment of an array of disturbances, especially skin disorders. The wound-healing effects have been attributed to its moisturizing and anti-inflammatory effects as well as its beneficial effect on the maturation of collagen. The aim of the present study is to compare the effects of topically applied extracts of Aloe ferox with that of Aloe vera on the symptoms as well as IgE levels of a mouse model of atopic dermatitis (AD). Mice were sensitized and challenged with 2,4-dinitrochlorobenzene and treated afterwards for 10 consecutive days with the gels of either A. ferox or A. vera applied topically to the affected areas. A placebo gel was used for the control mice. Blood was collected at the beginning and end of the treatment period to measure serum IgE levels. Although the gels of both the Aloe species inhibited the cutaneous inflammatory response as well as serum IgE levels in the rats, the extracts of A. ferox were superior to that of A. vera in reducing IgE levels. The gels of A. ferox and A. vera, applied topically, may be a safe and useful alternative to antihistamines and topical corticosteroids, for the treatment of patients suffering from recurring chronic AD.

Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP).

Science.gov (United States)

1997-05-01

In this pilot study, aimed at exploring the feasibility of a large-scale trial of low-dose aspirin in polycythaemia vera (PV), 112 PV patients (42 females, 70 males. aged 17-80 years) were selected for not having a clear indication for, or contraindication to, aspirin treatment and randomized to receive oral aspirin (40 mg/d) or placebo. Follow-up duration was 16 +/- 6 months. Measurements of thromboxane A2 production during whole blood clotting demonstrated complete inhibition of platelet cyclooxygenase activity in patients receiving aspirin. Aspirin administration was not associated with any bleeding complication. Within the limitations of the small sample size, this study indicates that a biochemically effective regimen of antiplatelet therapy is well tolerated in patients with polycythaemia vera and that a large-scale placebo-controlled trial is feasible.

A randomized, double‑blind clinical study to assess the antiplaque and antigingivitis efficacy of Aloe vera mouth rinse

Directory of Open Access Journals (Sweden)

Bathini Chandrahas

2012-01-01

Full Text Available Aims: To evaluate the efficacy of Aloe Vera mouth rinse on experimental plaque accumulation and gingivitis. Materials and Methods: In this randomized, controlled, and double-blind study, a total of 148 systemically healthy subjects were screened in the age group of 18-25 years. Finally, 120 subjects were requested to abstain from oral hygiene (tooth brushing for 14 days and used a specially fabricated plaque guard. Following cessation of tooth brushing in the specified area, the subjects were randomly divided into Group A (test group who received 100% Aloe vera, Group B (negative control group who received placebo (distilled water, and Group C (positive control group who received 0.2% chlorhexidine. The rinse regimen began on the 15 th day and continued for 7 days. Plaque accumulation was assessed by Plaque Index (PI and gingivitis was assessed by Modified Gingival Index (MGI and Bleeding Index (BI at baseline (0, 7 th , 14 th , and 22 nd days. Results: There was statistically significant decrease in PI, MGI, and BI scores after the rinse regimen began in both Group A (test group and Group C (chlorhexidine compared with Group B. Mouth wash containing Aloe vera showed significant reduction of plaque and gingivitis but when compared with chlorhexidine the effect was less significant. Conclusion: Aloe vera mouthwash can be an effective antiplaque agent and with appropriate refinements in taste and shelf life can be an affordable herbal substitute for chlorhexidine.

The Impact of Aloe vera and Calendula on Perineal Healing after Episiotomy in Primiparous Women: A Randomized Clinical Trial

Directory of Open Access Journals (Sweden)

Farideh Eghdampour

2013-11-01

Full Text Available Introduction: Episiotomy is used for enlarging the perineum. Aloe vera and Calendula have been used for treating different diseases from ancient times, limited researches have been done regarding the healing of these plants. Since the effect of their ointment on episiotomy healing has not been studied, this study is being done for determining the impact of Aloe vera and Calendula on episiotomy healing in primiparous women. Methods: This clinical trial involves 111 qualified primiparous women admitted in Lolagar hospital. They were randomly categorized into three groups of control (n=1 and experimental (n=2 groups. The women in experimental group used Aloe vera and Calendula Ointment every 8 hours and the control group used hospital routine on episiotomy for 5 days. The data were collected by demographic questionnaire and redness, edema, ecchymosis, discharge and approximation scale (REEDA which investigated the episiotomy healing before and five days after intervention in two groups. ANOVA, Tukey test, Kruskal-wallis, Chi-square were used for data analysis. Results: The three groups do not have statistically significant different regarding demographic and other intervening variables. Comparing the mean of REEDA in five days after delivery showed statistically significant difference between control and experimental groups.Conclusion: According to the results, using Aloe vera and Calendula ointment considerably increases the speed of episiotomy wound healing so it can be used for quickening the episiotomy healing.

Bone mineral density and microarchitecture in patients with essential thrombocythemia and polycythemia vera

DEFF Research Database (Denmark)

Farmer, S.; Shanbhogue, V. V.; Hansen, S.

2017-01-01

In this cross-sectional study of 45 patients with myeloproliferative neoplasms, we found no evidence of secondary osteoporosis. INTRODUCTION: Patients with essential thrombocythemia (ET) and polycythaemia vera (PV) are at increased risk of fractures but the underlying mechanisms have not been set...

Three mitogen-activated protein kinases required for cell wall integrity contribute greatly to biocontrol potential of a fungal entomopathogen.

Directory of Open Access Journals (Sweden)

Ying Chen

Full Text Available Bck1, Mkk1 and Slt2 are three mitogen-activated protein (MAP kinases constituting cell wall integrity (CWI pathway that may control multi-stress responses via crosstalk with high-osmolarity glycerol (HOG pathway in budding yeast. In this study, Bck1, Mkk1 and Slt2 orthologues in Beauveria bassiana were confirmed as the three-module cascade essential for CWI because cell wall impairment occurred in the hyphae and conidia of Δbck1, Δmkk1 and Δslt2 examined in multiple experiments. Strikingly, all the deletion mutants became more sensitive to hyperosmotic NaCl and sorbitol with the Western blot of Hog1 phosphorylation being weakened in Δbck1 and absent in Δmkk1 and Δslt2. Apart from crossing responses to cell wall perturbation and high osmolarity, three deletion mutants exhibited faster growth and conidiation on nutrition-rich medium, much less virulence to Galleria mellonella larvae, and higher sensitivity to nutritional, fungicidal, thermal and UV-B irradiative stresses, accompanied with less accumulation of intracellular mannitol and trehalose. Moreover, Δmkk1 and Δslt2 were equally more sensitive to all the stresses of different types except wet-heat stress than wild type and more or less different from Δbck1 in sensitivity to most of the stresses despite their null responses to two oxidants. All the changes in three deletion mutants were restored by each targeted gene complementation. Taken together, the CWI-required Bck1, Mkk1 and Slt2 are all positive, but differential, regulators of multi-stress tolerance and virulence perhaps due to interplay with the HOG pathway essential for osmoregulation, thereby contributing greatly to the biocontrol potential of the fungal entomopathogen.

Toxicology and carcinogenesis studies of a nondecolorized [corrected] whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study).

Science.gov (United States)

Boudreau, M D; Beland, F A; Nichols, J A; Pogribna, M

2013-08-01

Extracts from the leaves of the Aloe vera plant (Aloe barbadensis Miller) have long been used as herbal remedies and are also now promoted as a dietary supplement, in liquid tonics, powders or tablets, as a laxative and to prevent a variety of illnesses. We studied the effects of Aloe vera extract on rats and mice to identify potential toxic or cancer-related hazards. We gave solutions of nondecolorized extracts of Aloe vera leaves in the drinking water to groups of rats and mice for 2 years. Groups of 48 rats received solutions containing 0.5%, 1% or 1.5% of Aloe vera extract in the drinking water, and groups of mice received solutions containing 1%, 2%, or 3% of Aloe vera extract. Similar groups of animals were given plain drinking water and served as the control groups. At the end of the study tissues from more than 40 sites were examined for every animal. In all groups of rats and mice receiving the Aloe vera extract, the rates of hyperplasia in the large intestine were markedly increased compared to the control animals. There were also increases in hyperplasia in the small intestine in rats receiving the Aloe vera extract, increases in hyperplasia of the stomach in male and female rats and female mice receiving the Aloe vera extract, and increases in hyperplasia of the mesenteric lymph nodes in male and female rats and male mice receiving the Aloe vera extract. In addition, cancers of the large intestine occurred in male and female rats given the Aloe vera extract, though none had been seen in the control groups of rats for this and other studies at this laboratory. We conclude that nondecolorized Aloe vera caused cancers of the large intestine in male and female rats and also caused hyperplasia of the large intestine, small intestine, stomach, and lymph nodes in male and female rats. Aloe vera extract also caused hyperplasia of the large intestine in male and female mice and hyperplasia of the mesenteric lymph node in male mice and hyperplasia of the stomach

On hyper BCC-algebras

OpenAIRE

Borzooei, R. A.; Dudek, W. A.; Koohestani, N.

2006-01-01

We study hyper BCC-algebras which are a common generalization of BCC-algebras and hyper BCK-algebras. In particular, we investigate different types of hyper BCC-ideals and describe the relationship among them. Next, we calculate all nonisomorphic 22 hyper BCC-algebras of order 3 of which only three are not hyper BCK-algebras.

A retrospective analysis of the impact of treatments and blood counts on survival and the risk of vascular events during the course of polycythaemia vera

DEFF Research Database (Denmark)

Enblom-Larsson, Anneli; Girodon, Francois; Bak, Marie

2017-01-01

Vascular and non-vascular complications are common in patients with polycythaemia vera. This retrospective study of 217 patients with polycythaemia vera aimed to determine whether blood counts with respect to different treatments influenced the complication rate and survival. We found that 78 (36...

Perbedaan Efek Pemberian Topikal Gel Lidah Buaya (Aloe vera L. Dengan Solusio Povidone Iodine Terhadap Penyembuhan Luka Sayat Pada Kulit Mencit (Mus musculus

Directory of Open Access Journals (Sweden)

Nur Atik

2009-06-01

Full Text Available Normal wound healing is a complex and dynamic process. Wound healing process can accelerate, with chemical treatment or natural. The chemical treatment often used in healing process is povidone iodine. For natural treatment, topical application of Aloe vera gel may accelerate the full-thickness wound healing process. The purpose of this research was to evaluate the differences between topical application of povidone iodine and Aloe vera gel for skin wound healing in mice. This study used 18 mice that were divided into three groups. First group was the wounded (control group, the second group was wounded – Aloe vera group, the third group was wounded - povidone iodine group. Full-thickness skin wound were created on the dorsal area of mice in each group. The control group were not given anything, while the second group were given Aloe vera gel twice a day, and the third group were given povidone iodine solution twice a day. At the fifth day, all mice were sacrificed for histologic evaluation and VEGF A expression. Data was obtained by microscopic observation of the wounded skin, based on quantitative parameter: epithelial thickness, total fibroblast, total blood vessels, and VEGF A expression. Then the data was statistically analyzed by using independent samples T test, ANOVA, and Chi square. The result demonstrated that the sum of epithelial thickness, fibroblast, blood vessels, and VEGF A expression in the Aloe vera group is higher than in povidone iodine group. Statistic evaluation showed that there were significant differences between the two groups (p < 0.05, with 95% confidence interval. Based on this result, it can be concluded that the topical administration of Aloe vera gel twice a day is better than povidone iodine with parameter epithelial thickness, total fibroblass, total blood vessels and VEGF A expression.

An evaluation of the impact of aloe vera and licorice extracts on the course of experimental pigeon paramyxovirus type 1 infection in pigeons.

Science.gov (United States)

Dziewulska, D; Stenzel, T; Smialek, M; Tykalowski, B; Koncicki, A

2018-02-01

The progressive decrease in the efficiency of synthetic drugs has prompted research into phytogenic feed additives with potentially immunomodulatory and anti-infective properties. Complex diseases with a mixed etiology, including viral, pose a growing problem in domestic pigeons. The aim of this study was to determine the effectiveness of various doses of aloe vera and licorice extracts on the course of experimental PPMV-1 infection in pigeons. The experiment was performed on pigeons divided into 5 groups, including one control group and 4 experimental groups, which were orally administered aloe vera or licorice extracts at 300 or 500 mg/kg BW for 7 d after experimental inoculation with PPMV-1. On d 4, 7, and 14 after inoculation, cloacal swabs and samples of organs were collected from 4 birds in each group. The samples were analyzed to determine the copy number of PPMV-1 RNA by TaqMan qPCR. The results indicate that licorice and aloe vera extracts inhibited PPMV-1 replication by decreasing viral RNA copy numbers in the examined organs. The most inhibitory effect was observed in pigeons receiving aloe vera extract at 300 mg/kg BW, for which PPMV-1 RNA copy numbers were approximately 7-fold lower (brain), 9-fold lower (kidneys), and 14-fold lower (liver) than in the control group. The results of this study point to the potentially antiviral effects of aloe vera and licorice extracts in pigeons infected with PPMV-1. To the best of our knowledge, this is the first study to investigate the antiviral properties of aloe vera and licorice extracts in domestic pigeons. © The Author 2017. Published by Oxford University Press on behalf of Poultry Science Association.

BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report.

Science.gov (United States)

Cornea, Mihaela I Precup; Levrat, Emmanuel; Pugin, Paul; Betticher, Daniel C

2015-04-08

The World Health Organization classification of chronic myeloproliferative disease encompasses eight entities of bone marrow neoplasms, among them Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia and polycythemia vera. Polycythemia vera requires, in the majority of cases (95%), the negativity of Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 rearrangement and the presence of the Janus kinase 2 mutation. We report a case of erythrocytosis as the primary manifestation of a chronic myeloid leukemia, with the presence of the Philadelphia chromosome and the Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 fusion gene, and in the absence of any Janus kinase 2 mutation. A 68-year-old Caucasian woman, with a history of cigarette consumption and obstructive sleep apnoea syndrome (undergoing continuous positive airway pressure treatment) had presented to our institution with fatigue and a hemoglobin level of 18.6g/L, with slight leukocytosis at 16G/L, and no other anomalies on her complete blood cell count. Examination of her arterial blood gases found only a slight hypoxemia; erythropoietin and ferritin levels were very low and could not explain a secondary erythrocytosis. Further analyses revealed the absence of any Janus kinase 2 mutation, thus excluding polycythemia vera. Taken together with a high vitamin B12 level, we conducted a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 gene analysis and bone marrow cytogenetic analysis, both of which returned positive, leading to the diagnosis of chronic myeloid leukemia. To date, this case is the first description of a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia, presenting with erythrocytosis as the initial manifestation, and mimicking a Janus kinase 2 V617F-negative polycythemia vera. Her impressive response to imatinib

Potential effect of fortified pan bread with Aloe vera juice on alloxan ...

African Journals Online (AJOL)

Background: This study was designed to investigate (1) the potential use of Aloe vera juice (AVJ) for fortification of pan bread with evaluates the sensory characteristics and the nutritive value. (2) The possible beneficial role of 5% and 10% AVJ-fortified bread against diabetic rats. Materials and Methods: Bread fortified with ...

The influence of Aloe vera and xenograft XCB toward of bone morpho protein 2 BMP2 expression and amount of osteoblast of alveolar bone induced into tooth extraction sockets Cavia cobaya

Directory of Open Access Journals (Sweden)

Utari Kresnoadi

2014-12-01

Full Text Available Tooth extraction can cause inflammation leading to alveolar ridge resorption. In addition, prominent ridge has crucial role for making denture su-ccessfully. Thus, socket preservation is needed to prevent greater alveolar ridge resorption. An innovative material, a combination of Aloe vera and xe-nograft (XCB, is then considered as a biogenic stimulator that can reduce inflammation, as a result, the growth of alveolar bone is expected to be impro-ved. This research is aimed to prove whether the mixture of Aloe vera and xenograft can stimulate BMP2 and increase osteoblasts. Forty-eight Cavia co-baya animals were divided into eight groups each of which consisted of six animals. The mandibular incisors of those Cavia cobaya animals were then extracted and filled with PEG as Group Control, XCB as Group XCB, Aloe vera as Group Aloe vera, and a combination of Aloe vera +XCB as Group Aloe vera +XCB. Next, the first four groups were sacrificed seven days after extraction, and the second four groups were sacrificed 30 days after extrac-tion. And then, immunohistochemical and histopathology examinations were conducted to examine BMP2 expression and osteoblasts. Based on the re-sult known that the mixture of Aloe vera and xenograft can increase BMP2 expression and amount of osteoblasts. It can be concluded that the mixture of Aloe vera and xenograft can increase BMP2 expression and amount of osteoblast cel . It can be used as an alternative material to increase the growth of alveolar bone after extraction.

On hyper BCC-algebras

Directory of Open Access Journals (Sweden)

R. A. Borzooei

2006-01-01

Full Text Available We study hyper BCC-algebras which are a common generalization of BCC-algebras and hyper BCK-algebras. In particular, we investigate different types of hyper BCC-ideals and describe the relationship among them. Next, we calculate all nonisomorphic 22 hyper BCC-algebras of order 3 of which only three are not hyper BCK-algebras.

Effect of Aloe vera (Aloe barbadensis Miller) on survivability, extent of proteolysis and ACE inhibition of potential probiotic cultures in fermented milk.

Science.gov (United States)

Basannavar, Santosh; Pothuraju, Ramesh; Sharma, Raj Kumar

2014-10-01

In the present investigation, the effect of Aloe vera gel powder on angiotensin-converting enzyme (ACE) inhibitory activity, extent of proteolysis during fermentation and survival of Lactobacillus casei NCDC19 during storage of fermented milk was studied. Among the different cultures screened for ACE inhibitory activity, Lactobacillus casei NCDC 19 exhibited the highest ACE inhibition (approx. 40%) as well as extent of proteolysis (0.37, Abs₃₄₀). In the presence of Aloe vera (0.5% and 1% w/v) an increase in extent of proteolysis (0.460 ± 0.047 and 0.480 ± 0.027) and percent ACE inhibitory activity (44.32 ± 2.83 and 47.52 ± 1.83) was observed in comparison to control. Aloe vera powder addition also led to an increase in viable counts (>11 log cfu mL⁻¹) of L. casei NCDC 19 in fermented milk during storage for 7 days and the counts were maintained in sufficiently higher numbers. The study suggests Aloe vera to be a good functional ingredient which can be further explored for different health attributes. © 2014 Society of Chemical Industry.

Evaluation of Isolated Fractions of Aloe vera Gel Materials on Indinavir Pharmacokinetics: In vitro and in vivo Studies.

Science.gov (United States)

Wallis, Lonette; Malan, Maides; Gouws, Chrisna; Steyn, Dewald; Ellis, Suria; Abay, Efrem; Wiesner, Lubbe; Otto, Daniel P; Hamman, Josias

2016-01-01

Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed medicines. A. vera gel has shown the ability to modulate drug absorption in vitro. The aim of this study was to fractionate the precipitated polysaccharide component of A. vera gel based on molecular weight and to compare their interactions with indinavir pharmacokinetics. Crude polysaccharides were precipitated from a solution of A. vera gel and was fractionated by means of centrifugal filtration through membranes with different molecular weight cut-off values (i.e. 300 KDa, 100 KDa and 30 KDa). Marker molecules were quantified in the aloe leaf materials by means of nuclear magnetic resonance spectroscopy and the average molecular weight was determined by means of gel filtration chromatography linked to multi-angle-laser-light scattering and refractive index detection. The effect of the aloe leaf materials on the transepithelial electrical resistance (TEER) of Caco-2 cell monolayers as well as indinavir metabolism in LS180 cells was measured. The bioavailability of indinavir in the presence and absence of the aloe leaf materials was determined in Sprague-Dawley rats. All the aloe leaf materials investigated in this study reduced the TEER of Caco-2 cell monolayers, inhibited indinavir metabolism in LS 180 cells to different extents and changed the bioavailability parameters of indinavir in rats compared to that of indinavir alone. These indinavir pharmacokinetic modulation effects were not dependent on the presence of aloverose and also not on the average molecular weight of the isolated fractions.

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India.

Science.gov (United States)

Kumar, Sandeep; Yadav, Manila; Yadav, Amita; Rohilla, Pooja; Yadav, Jaya Parkash

2017-07-17

In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of crude aqueous extracts was done to estimate the effects of these constituents on antiplasmodial potential of the plant. HPTLC system equipped with a sample applicator Linomat V with CAMAG sample syringe, twin rough plate development chamber (20 x 10 cm), TLC Scanner 3 and integration software WINCATS 1.4.8 was used for analysis of aloin and aloe-emodin amount. The antiplasmodial activity of plant extracts was assessed against a chloroquine (CQ) sensitive strain of P. falciparum (MRC-2). Minimum Inhibitory Concentration (MIC) of aqueous extracts of selected samples was determined according to the World Health Organization (WHO) recommended method that was based on assessing the inhibition of schizont maturation in a 96-well microtitre plate. EC (effective concentration) values of different samples were observed to predict antiplasmodial potential of the plant in terms of their climatic zones. A maximum quantity of aloin and aloe-emodin i.e. 0.45 and 0.27 mg/g respectively was observed from the 12 samples of Aloe vera. The inhibited parasite growth with EC 50 values ranging from 0.289 to 1056 μg/ml. The antiplasmodial EC 50 value of positive control Chloroquine was observed 0.034 μg/ml and EC 50 values showed by aloin and aloe-emodin was 67 μg/ml and 22 μg/ml respectively. A positive correlation was reported between aloin and aloe-emodin. Antiplasmodial activity was increased with increase in the concentration of aloin and aloe-emodin. The quantity of aloin and aloe-emodin was decreased with rise in temperature hence it was negatively correlated with temperature. The extracts of Aloe vera collected from colder climatic regions showed good antiplasmodial activity and also showed the presence of higher amount of aloin and

Efecto biofungicida del gel de Aloe vera sobre Mycosphaerella fijiensis, agente causal de la Sigatoka negra en Musa (AAA

Directory of Open Access Journals (Sweden)

Edwin Jaramillo Aguilar

2017-01-01

Full Text Available El objetivo de este trabajo fue evaluar a nivel in vitro la actividad antifúngica del gel de Aloe vera sobre el crecimiento micelial de Mycosphaerella fijiensis. Se utilizó la técnica de envenenamiento en el medio de cultivo PDA para determinar la actividad antifúngica del gel. El diseño utilizado fue completamente al azar, con siete tratamientos y tres repeticiones. En los tratamientos se utilizó un fungicida químico comercial (propiconazol, a 250 ppm y 500 ppm; un biofungicida comercial (Trichoderma sp. a 500 ppm y 1000 ppm; ambos productos se usaron como testigo químico y biológico, respectivamente; el gel de Aloe vera a 500 ppm y 1000 ppm; y un testigo absoluto. Se determinó diferencias significativas entre los tratamientos (ANOVA, El test de Tukey demostró que todos los tratamientos registraron diferencia significativa (p ≤ 0,05 con respecto al testigo absoluto. El propiconazol presentó el mayor porcentaje de inhibición del micelio (73,10%; el test de Tukey y el porcentaje de inhibición del micelio presentaron valores similares en el control del crecimiento del hongo a los 30 días de inoculación, en los tratamientos gel de Aloe vera y el T6 de Trichoderma sp. Los resultados sugieren que el Aloe vera podría ser un adecuado biofungicida para el control de Mycosphaerella fijiensis, agente causal de la Sigatoka negra.

Bilateral adrenal hemorrhage in polycythemia vera

Directory of Open Access Journals (Sweden)

Shruti Bhandari

2016-09-01

Full Text Available Bilateral adrenal hemorrhage (BAH is a rare complication typically seen in critically ill patients, which can lead to acute adrenal insufficiency and death unless it is recognized promptly and treated appropriately. We describe the case of a 64-year-old man with polycythemia vera found to be unresponsive with fever, hypotension, tachycardia, and hypoglycemia. Electrocardiogram showed ST-elevation with elevated troponin, hemoglobin, prothrombin time, and partial thromboplastin time. He required aggressive ventilator and vasopressor support. Despite primary coronary intervention, he remained hypotensive. Random cortisol level was low. He received stress dose hydrocortisone with immediate hemodynamic stability. BAH was highly suspected and was confirmed by non-contrast abdominal computed tomography. Prompt recognition and timely initiated treatment remain crucial to impact the mortality associated with acute adrenal insufficiency.

Subacute Budd-Chiari syndrome associated with polycythemia vera and factor V Leiden mutation

NARCIS (Netherlands)

Simsek, S; Verheesen, RV; Haagsma, EB; Lourens, J

We describe a 48-year-old caucasian woman with a subacute Budd-Chiari syndrome attributed to the presence of polycythaemia vera, heterozygosity for the factor V Leiden mutation and the use of an oral contraceptive pill. Two diagnostic pitfalls were encountered. First, on CT scanning of the abdomen

Antiviral activity of Aloe vera against herpes simplex virus type 2: An ...

African Journals Online (AJOL)

SERVER

2007-08-06

Aug 6, 2007 ... In this study we tested the antiviral activity of a crude hot glycerine extract of Aloe vera gel which was grown in Bushehr (Southwest of Iran) against HSV-2 replication in Vero cell line. The extract showed antiviral activity against HSV-2 not only before attachment and entry of virus to the Vero cells but also.

Cavity disinfection in minimally invasive dentistry - comparative evaluation of Aloe vera and propolis: A randomized clinical trial

Directory of Open Access Journals (Sweden)

A R Prabhakar

2015-01-01

Full Text Available Context: The survival of atraumatic restorative treatment (ART restorations would probably increase if near total elimination of cariogenic microorganisms could be done in the process of cavity cleaning before going ahead with the restoration. Thus, use of naturally occurring disinfecting agents for achieving this goal could herald a new beginning in the field of contemporary minimum intervention dentistry. Aims: To evaluate the efficacy of hand instruments in excavating dental caries and comparatively evaluate the roles of Aloe vera and propolis as potential cavity disinfecting agents after minimally invasive hand excavation of dental caries. Settings and Designs: Experimental, in vivo intergroup split mouth, randomized clinical trial. Subjects and Methods: The study included Group I (Control, Group II (A. vera and Group III (propolis. Ten patients with three teeth each have occlusal/occlusoproximal lesions suitable for ART were selected. Dentinal samples were collected three times from each tooth viz., preexcavation, postexcavation and postdisinfection of the cavities. These dentinal samples were subjected to microbiological analyses for total viable count. Statistical Analysis Used: Repeated measures of analysis of variance (ANOVA with Bonferroni post-hoc test and one-way ANOVA with Tukey post-hoc test. Results: In all the three groups, significant amount of bacteria were left behind after hand excavation. Group II and Group III, in which cavities were treated with A. vera and propolis extracts respectively, showed a significant reduction in the bacterial counts when compared to control the group. Conclusions: Hand excavation alone does not completely eliminate bacteria, which may predispose treated teeth to secondary caries. Both propolis and A. vera extracts can be used as potential natural disinfecting agents, thereby embracing the concept of phytotherapy in minimum intervention dentistry.

Optimisation of nitrogen and potassium for Aloe vera (L.) Burm.f. in a ...

African Journals Online (AJOL)

Aloe vera (L.) Burm.f. is highly appreciated due to its short growth period and high economic value among all Aloe species, and is used in pharmaceuticals, folk medicine, healthcare, cosmetic products and food products. Hydroponic systems have the potential to improve the cropping management and to achieve higher ...

Processing and stabilization of Aloe Vera leaf gel by adding chemical and natural preservatives

Directory of Open Access Journals (Sweden)

N. Nazemi

2017-11-01

Full Text Available Background and objectives: Aloe vera has been used as a medicinal herb for thousands of years. Aloe vera leaves can be separated into latex and gel which have biological effects. Aloe gel is a potent source of polysaccharides. When the gel is exposed to air, it quickly decomposes and decays and loses most of its biological activity. There are various processing techniques for sterilizing and stabilizing the gel. The aim of this study was to improve stabilization of the gel by adding some chemical and natural preservatives. Methods: The gel was obtained from Aloe vera leaves and after some processing chemical and natural preservatives were added. Chemicals included citric acid, ascorbic acid, vitamin E and potassium sorbate while natural preservatives were two essential oils derived from Cinnamomum zeylanicum and Eugenia caryophyllata. All these operations were performed under sterile conditions and they were evaluated at different temperatures and times. Appearance and taste changes of gel were studied organoleptic. Microbiological tests and some physical assays such as pH, refractometry and viscosity properties as well as determination of total sugars were measured. NMR and FT-IR analyses were performed for determining the quality of samples. Results: After data analyzing, the results showed that the samples formulated with chemical additives together with essential oils were more suitable and stable compared to the control samples after 90 days and the effective ingredient acemannan, remained stable. Conclusion: The stable gel can be considered for therapeutic properties and be used for edible and medicinal purposes.

A dementia communication training intervention based on the VERA framework for pre-registration nurses: Part I developing and testing an implementation strategy.

Science.gov (United States)

Naughton, Corina; Beard, Chloe; Tzouvara, Vasiliki; Pegram, Anne; Verity, Rebecca; Eley, Rhiannon; Hingley, David

2018-04-01

People living with dementia experience progressive difficulty in expressing physical and emotional needs. Health care staff including student nurses require training to develop compensatory communication strategies. However, there is no standardised foundation level dementia communication training within pre-registration curricula. This article describes the theoretical underpinnings and development of a foundation level dementia communication skills training based on the VERA (Validation, Emotion, Reassurance, Activity) framework. The training strategies drew on behavioural change theory using the COM-B model and Gagné's 9 Events of Instruction. The VERA framework was operationalised using a multicomponent teaching strategy. The intervention was refined based on quality improvement Plan-Do-Study-Act cycles with feedback from people living with dementia, facilitators and student nurses. Data collection used semi-structured questionnaires (n = 51) and four focus group (n = 19) interviews with students. Data analysis involved descriptive statistics and thematic analysis. The intervention was a 2.5-hour face-to-face training session delivered at the start of students' older adult unit placement with follow-up reflection sessions during placement. Training was delivered to 51 students, all students described the training as useful and would recommend it to their peers. Elements of the training that were highly valued were: opportunities to express concerns in caring for people with dementia, applying the VERA framework using role play and outlining realistic expectations of VERA. Students recognised the need for on-going training especially for more complex patients. Combining behaviour change and education theory with stakeholder feedback strengthened the development of VERA as a foundation level dementia communication training for pre-registration nurses. Copyright © 2018 Elsevier Ltd. All rights reserved.

Polymeric Films Loaded with Vitamin E and Aloe vera for Topical Application in the Treatment of Burn Wounds

Directory of Open Access Journals (Sweden)

Gabriela Garrastazu Pereira

2014-01-01

Full Text Available Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera and vitamin E have been demonstrated to be beneficial in formulations for wound healing. The aim of this work is to develop and evaluate polymeric films containing Aloe vera and vitamin E to treat wounds caused by burns. Polymeric films containing different quantities of sodium alginate and polyvinyl alcohol (PVA were characterized for their mechanical properties and drug release. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on damaged skin, such as in burn wounds. Around 30% of vitamin E acetate was released from the polymeric films within 12 hours. The in vivo experiments with tape stripping indicated an effective accumulation in the stratum corneum when compared to a commercial cream containing the same quantity of vitamin E acetate. Vitamin E acetate was found in higher quantities in the deep layers of the stratum corneum when the film formulation was applied. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of burns.

Mechanical, Thermal, and Morphological Properties of Nanocomposites Based on Polyvinyl Alcohol and Cellulose Nanofiber from Aloe vera Rind

Directory of Open Access Journals (Sweden)

Adel Ramezani Kakroodi

2014-01-01

Full Text Available This work was devoted to reinforcement of polyvinyl alcohol (PVA using cellulose nanofibers from Aloe vera rind. Nanofibers were isolated from Aloe vera rind in the form of an aqueous suspension using chemimechanical technique. Mechanical characterizations showed that incorporation of even small amounts of nanofibers (as low as 2% by weight had significant effects on both the modulus and strength of PVA. Tensile modulus and strength of PVA increased, 32 and 63%, respectively, after adding 2% of cellulose nanofiber from Aloe vera rind. Samples with higher concentrations of nanofibers also showed improved mechanical properties due to a high level of interfacial adhesion and also dispersion of fibers. The results showed that inclusion of nanofibers decreased deformability of PVA significantly. Dynamic mechanical analysis revealed that, at elevated temperatures, improvement of mechanical properties due to the presence of nanofibers was even more noticeable. Addition of nanofibers resulted in increased thermal stability of PVA in thermogravimetric analysis due to the reduction in mobility of matrix molecules. Morphological observations showed no signs of agglomeration of fibers even in composites with high cellulose nanofiber contents. Inclusion of nanofibers was shown to increase the density of composites.

Polymeric films loaded with vitamin E and aloe vera for topical application in the treatment of burn wounds.

Science.gov (United States)

Pereira, Gabriela Garrastazu; Guterres, Sílvia Stanisçuaki; Balducci, Anna Giulia; Colombo, Paolo; Sonvico, Fabio

2014-01-01

Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera and vitamin E have been demonstrated to be beneficial in formulations for wound healing. The aim of this work is to develop and evaluate polymeric films containing Aloe vera and vitamin E to treat wounds caused by burns. Polymeric films containing different quantities of sodium alginate and polyvinyl alcohol (PVA) were characterized for their mechanical properties and drug release. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on damaged skin, such as in burn wounds. Around 30% of vitamin E acetate was released from the polymeric films within 12 hours. The in vivo experiments with tape stripping indicated an effective accumulation in the stratum corneum when compared to a commercial cream containing the same quantity of vitamin E acetate. Vitamin E acetate was found in higher quantities in the deep layers of the stratum corneum when the film formulation was applied. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of burns.

Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb

Science.gov (United States)

Winters, Wallace D.; Scott, Michael; David, Andrew; Gillis, Glenn; Stoufflet, Thaya; Nair, Anand; Kousoulas, Konstantine

2013-01-01

Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies—examined grossly and microscopically—that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks. PMID:23554812

Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb

Directory of Open Access Journals (Sweden)

Inder Sehgal

2013-01-01

Full Text Available Aloe vera, a common ingredient in cosmetics, is increasingly being consumed as a beverage supplement. Although consumer interest in aloe likely stems from its association with several health benefits, a concern has also been raised by a National Toxicology Program Report that a nondecolorized whole leaf aloe vera extract taken internally by rats was associated with intestinal mucosal hyperplasia and ultimately malignancy. We tested a decolorized whole leaf (DCWL aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. We found this DCWL aloe vera juice to be nongenotoxic in histidine reversion and DNA repair assays. Following acute administration, mice exhibited no adverse signs at 3- or 14-day evaluation periods. When fed to male and female F344 rats over 13 weeks, DCWL aloe led to no toxicity as assessed by behavior, stools, weight gain, feed consumption, organ weights, and hematologic or clinical chemistry profiles. These rats had intestinal mucosal morphologies—examined grossly and microscopically—that were similar to controls. Our studies show that oral administration of this DCWL aloe juice has a different toxicology profile than that of the untreated aloe juice at exposures up to 13 weeks.

Risk factors and prevention of vascular complications in polycythemia vera.

Science.gov (United States)

Barbui, T; Finazzi, G

1997-01-01

Risk factors for vascular complications in polycythemia vera (PV) include laboratory and clinical findings. Among laboratory values, the hematocrit has been clearly associated with thrombosis, particularly in the cerebral circulation. Platelet count is a possible but not yet clearly established predictor of vascular complications. Platelet function tests are of little help in prognostic evaluation because most attempts to correlate these abnormalities with clinical events have been disappointing. Clinical predictors of thrombosis include increasing age and a previous history of vascular events. Identifying risk factors for thrombosis is important to initiate therapy. Phlebotomy is associated with an increased incidence of thrombosis in the first 3 to 5 years, whereas chemotherapy may induce a higher risk of secondary malignancies after 7 to 10 years of follow-up. New cytoreductive drugs virtually devoid of mutagenic risk include interferon-alpha and anagrelide, but their role in reducing thrombotic complications remains to be demonstrated. Antithrombotic drugs, such as aspirin, are frequently used in PV, despite doubts regarding safety and efficacy. Two recent studies from the Gruppo Italiano Studio Policitemia Vera (GISP) assessed the rate of major thrombosis as well as the tolerability of low-dose aspirin in PV patients. These investigations created a favorable scenario for launching a European collaborative clinical trial (ECLAP study) aimed at testing the efficacy of low-dose aspirin in preventing thrombosis and prolonging survival in patients with PV.

Aloe vera Induced Biomimetic Assemblage of Nucleobase into Nanosized Particles

Science.gov (United States)

Chauhan, Arun; Zubair, Swaleha; Sherwani, Asif; Owais, Mohammad

2012-01-01

Aim Biomimetic nano-assembly formation offers a convenient and bio friendly approach to fabricate complex structures from simple components with sub-nanometer precision. Recently, biomimetic (employing microorganism/plants) synthesis of metal and inorganic materials nano-particles has emerged as a simple and viable strategy. In the present study, we have extended biological synthesis of nano-particles to organic molecules, namely the anticancer agent 5-fluorouracil (5-FU), using Aloe vera leaf extract. Methodology The 5-FU nano- particles synthesized by using Aloe vera leaf extract were characterized by UV, FT-IR and fluorescence spectroscopic techniques. The size and shape of the synthesized nanoparticles were determined by TEM, while crystalline nature of 5-FU particles was established by X-ray diffraction study. The cytotoxic effects of 5-FU nanoparticles were assessed against HT-29 and Caco-2 (human adenocarcinoma colorectal) cell lines. Results Transmission electron microscopy and atomic force microscopic techniques confirmed nano-size of the synthesized particles. Importantly, the nano-assembled 5-FU retained its anticancer action against various cancerous cell lines. Conclusion In the present study, we have explored the potential of biomimetic synthesis of nanoparticles employing organic molecules with the hope that such developments will be helpful to introduce novel nano-particle formulations that will not only be more effective but would also be devoid of nano-particle associated putative toxicity constraints. PMID:22403622

Evaluation of wound healing treated with latex derived from rubber trees and Aloe Vera extract in rats.

Science.gov (United States)

Brandão, Marcelo Luiz; Reis, Paulo Roberto Melo; Araújo, Lilhian Alves de; Araújo, Ana Carolina Vicente; Santos, Maisa Helena de Abreu Silva; Miguel, Marina Pacheco

2016-09-01

To compare the use of latex derivative and Aloe vera extract to wound healing. Twenty one rats were randomly divided into three groups and each one had a wound made by incision. The treatment consisted in: derivative of latex (GL), Aloe vera extract (GA) and saline solution (GC). The wound area was measured on the 7th, 14th and 21st days and macroscopic and microscopic evaluation were done. The comparison between the measurements of the wounds presented statistical difference in GC and GA from the 7th day of evaluation and GL from the 14th day. The extent of the wound was significantly smaller by the 7th day in GL. Histologically, in GL, the neovascularization was significant on the 7th, 14th and 21st days. On the 21st day the scar was large and little mature. In GA and GC, the findings were similar on the 7th, 14th and 21st days with a slight better organization of skin and collagen on the 21st in GA. Statistical analysis did not allow for the definition of the best topical agent. The latex had the highest angiogenesis, but a possible foreign body granuloma. Aloe vera has revealed a healing process adequated temporally in histology.

Risk of thrombosis according to need of phlebotomies in patients with polycythemia vera treated with hydroxyurea.

Science.gov (United States)

Alvarez-Larrán, Alberto; Pérez-Encinas, Manuel; Ferrer-Marín, Francisca; Hernández-Boluda, Juan Carlos; Ramírez, María José; Martínez-López, Joaquín; Magro, Elena; Cruz, Yasmina; Mata, María Isabel; Aragües, Pilar; Fox, María Laura; Cuevas, Beatriz; Montesdeoca, Sara; Hernández-Rivas, José Angel; García-Gutiérrez, Valentín; Gómez-Casares, María Teresa; Steegmann, Juan Luis; Durán, María Antonia; Gómez, Montse; Kerguelen, Ana; Bárez, Abelardo; García, Mari Carmen; Boqué, Concepción; Raya, José María; Martínez, Clara; Albors, Manuel; García, Francesc; Burgaleta, Carmen; Besses, Carlos

2017-01-01

Hematocrit control below 45% is associated with a lower rate of thrombosis in polycythemia vera. In patients receiving hydroxyurea, this target can be achieved with hydroxyurea alone or with the combination of hydroxyurea plus phlebotomies. However, the clinical implications of phlebotomy requirement under hydroxyurea therapy are unknown. The aim of this study was to evaluate the need for additional phlebotomies during the first five years of hydroxyurea therapy in 533 patients with polycythemia vera. Patients requiring 3 or more phlebotomies per year (n=85, 16%) showed a worse hematocrit control than those requiring 2 or less phlebotomies per year (n=448, 84%). There were no significant differences between the two study groups regarding leukocyte and platelet counts. Patients requiring 3 or more phlebotomies per year received significantly higher doses of hydroxyurea than the remaining patients. A significant higher rate of thrombosis was found in patients treated with hydroxyurea plus 3 or more phlebotomies per year compared to hydroxyurea with 0-2 phlebotomies per year (20.5% vs. 5.3% at 3 years; Phydroxyurea was significantly higher in the group requiring 3 or more phlebotomies per year (18.7% vs. 7.1%; P=0.001) mainly due to extrahematologic toxicity. In conclusion, phlebotomy requirement under hydroxyurea therapy identifies a subset of patients with increased proliferation of polycythemia vera and higher risk of thrombosis. Copyright© Ferrata Storti Foundation.

Genome survey of pistachio (Pistacia vera L.) by next generation sequencing: Development of novel SSR markers and genetic diversity in Pistacia species

OpenAIRE

Ziya Motalebipour, Elmira; Kafkas, Salih; Khodaeiaminjan, Mortaza; ?oban, Nergiz; G?zel, Hatice

2016-01-01

Background Pistachio (Pistacia vera L.) is one of the most important nut crops in the world. There are about 11 wild species in the genus Pistacia, and they have importance as rootstock seed sources for cultivated P. vera and forest trees. Published information on the pistachio genome is limited. Therefore, a genome survey is necessary to obtain knowledge on the genome structure of pistachio by next generation sequencing. Simple sequence repeat (SSR) markers are useful tools for germplasm cha...

The effectiveness of Aloe vera barbadensis bioactives on laying hens on commercial farmers

Directory of Open Access Journals (Sweden)

Tiurma Pasaribu

2006-06-01

Full Text Available A field trial was conducted to study the effectiveness of dry gel Aloe vera (DG as a feed additive for laying hens in commercial farms. The trial was consisted of two treatments, one was control, commonly used farmer ration containing antibiotic of zinc bacitracin at 0.5 g/kg and the second feed containing DG equal to 1.0 g/kg. Every treatment had two replicates with 504 Loghman laying hens. The hen day production (% HD, egg weight, feed consumption, feed conversion ratio (FCR, egg quality comprising yolk colour, albumin and yolk weights, egg shell eight and thikness, and mortality were observed for 24 weeks. The results showed that feed consumption, % HD, egg weight, FCR, yolk colour, albumin weight, yolk weight, egg shell weight, and egg shell thickness were not significantly different (P>0.05 between the control and DG treatment, except for the Haugh unit (HU. Thus, it can be concluded that Aloe vera bioactives has the same effectiveness as antibiotic as a feed additive at the level of commercial farms.

A feasibility study of dementia communication training based on the VERA framework for pre-registration nurses: Part II impact on student experience.

Science.gov (United States)

Naughton, Corina; Beard, Chloe; Tzouvara, Vasiliki; Pegram, Anne; Verity, Rebecca; Eley, Rhiannon; Hingley, David

2018-04-01

People living with dementia have complex communication needs, especially during acute hospital admissions. The VERA framework (validation, emotion, reassurance, activity) was designed to promote person centred communication between student nurses and people living with dementia, but there is limited evaluation of its impact. To measure the impact of dementia communication training (based on VERA) plus older adult unit (OAU) placement on students' ability to recognise opportunities for person centred (PC) communication compared to OAU placement alone. A control pre-post-study design was used. Dementia communication training plus follow-up during OAU placement was delivered to 51 students (5 OAU, two hospitals) while 66 students (7 OAUs, five hospitals) acted as controls. The primary outcome was students' ability to recognise PC communication assessed using case vignettes. Data were collected using electronic survey and focus group interviews. Data analysis used independent non-parametric Mann-Whitney U test and thematic analysis. In total 52 students (response rate 40%) completed surveys at the end of placements (38 intervention, 14 control group students). In the intervention group, participants were significantly more likely to identify PC responses with a mean score of 10.5 (SD 3.0) compared with 7.5 (SD 3.0) in the control group (p = 0.006). In focus group interviews (n = 19 students), the main themes were connecting with patients, VERA in practice, communication challenges, and learning environment. VERA was described as a flexible approach that added to participants' communication toolkit. The learning environment, complexity of patients and organisational resources were important contextual factors. The VERA framework has potential as a foundation level dementia communication training intervention, but it requires more rigorous testing. Nursing can lead the way in developing and embedding evidence-based, interdisciplinary dementia communication

Comparison of the antibacterial effect of sodium hypochlorite and aloe vera solutions as root canal irrigants in human extracted teeth contaminated with enterococcus faecalis.

Science.gov (United States)

Sahebi, S; Khosravifar, N; Sedighshamsi, M; Motamedifar, M

2014-03-01

The main purpose of a root canal treatment is to eliminate the bacteria and their products from the pulp space. Sodium hypochlorite has excellent antibacterial properties, but also some negative features. The aim of the present study is to compare the antimicrobial effect of Aloe Vera solution with sodium hypochlorite on E.faecalis in the root canals of human extracted teeth. Sixty human extracted single rooted teeth were selected for this in vitro study. The teeth recruited in this study had no cracks, internal resorption, external resorption and calcification. Enterococcus faecalis was injected in the root canals of all teeth. The teeth were then divided into three groups randomly. Each group consisted of 20 teeth that were all rinsed with one of the following solutions: sodium hypochlorite 2.5%, Aloe vera and normal saline. Subsequent to rinsing, root canals of all teeth were sampled. The samples were cultured and growth of the bacteria was assessed after 48 hours. The number of colonies of the bacteria was then counted. The difference between the inhibitory effect of Aloe vera and normal saline on E.faecalis was not significant according to independent t-test (p= 0.966). The inhibitory effect of sodium hypochlorite on E.faecalis was much greater than that of Aloe vera and normal saline (pvera solution is not recommended as a root canal irrigator, but future studies are suggested to investigate the antibacterial effect of Aloe vera with longer duration of exposure and as an intra canal medicament.

Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation.

Directory of Open Access Journals (Sweden)

Yun Sun Lee

Full Text Available Aloe vera (Asphodeloideae is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative secondary metabolites of Aloe vera are the anthraquinones including aloe emodin and chrysophanol, which are tricyclic aromatic quinones synthesized via a plant-specific type III polyketide biosynthesis pathway. However, it is not yet clear which cellular responses can induce the pathway, leading to production of tricyclic aromatic quinones. In this study, we examined the effect of endogenous elicitors on the type III polyketide biosynthesis pathway and identified the metabolic changes induced in elicitor-treated Aloe vera adventitious roots. Salicylic acid, methyl jasmonate, and ethephon were used to treat Aloe vera adventitious roots cultured on MS liquid media with 0.3 mg/L IBA for 35 days. Aloe emodin and chrysophanol were remarkably increased by the SA treatment, more than 10-11 and 5-13 fold as compared with untreated control, respectively. Ultra-performance liquid chromatography-electrospray ionization mass spectrometry analysis identified a total of 37 SA-induced compounds, including aloe emodin and chrysophanol, and 3 of the compounds were tentatively identified as tricyclic aromatic quinones. Transcript accumulation analysis of polyketide synthase genes and gas chromatography mass spectrometry showed that these secondary metabolic changes resulted from increased expression of octaketide synthase genes and decreases in malonyl-CoA, which is the precursor for the tricyclic aromatic quinone biosynthesis pathway. In addition, anti-inflammatory activity was enhanced in extracts of SA-treated adventitious roots. Our results suggest that SA has an important role in activation of the plant specific-type III polyketide biosynthetic pathway, and therefore that the efficacy of Aloe vera as medicinal agent can be improved through SA treatment.

Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation.

Science.gov (United States)

Lee, Yun Sun; Ju, Hyun Kyoung; Kim, Yeon Jeong; Lim, Tae-Gyu; Uddin, Md Romij; Kim, Yeon Bok; Baek, Jin Hong; Kwon, Sung Won; Lee, Ki Won; Seo, Hak Soo; Park, Sang Un; Yang, Tae-Jin

2013-01-01

Aloe vera (Asphodeloideae) is a medicinal plant in which useful secondary metabolites are plentiful. Among the representative secondary metabolites of Aloe vera are the anthraquinones including aloe emodin and chrysophanol, which are tricyclic aromatic quinones synthesized via a plant-specific type III polyketide biosynthesis pathway. However, it is not yet clear which cellular responses can induce the pathway, leading to production of tricyclic aromatic quinones. In this study, we examined the effect of endogenous elicitors on the type III polyketide biosynthesis pathway and identified the metabolic changes induced in elicitor-treated Aloe vera adventitious roots. Salicylic acid, methyl jasmonate, and ethephon were used to treat Aloe vera adventitious roots cultured on MS liquid media with 0.3 mg/L IBA for 35 days. Aloe emodin and chrysophanol were remarkably increased by the SA treatment, more than 10-11 and 5-13 fold as compared with untreated control, respectively. Ultra-performance liquid chromatography-electrospray ionization mass spectrometry analysis identified a total of 37 SA-induced compounds, including aloe emodin and chrysophanol, and 3 of the compounds were tentatively identified as tricyclic aromatic quinones. Transcript accumulation analysis of polyketide synthase genes and gas chromatography mass spectrometry showed that these secondary metabolic changes resulted from increased expression of octaketide synthase genes and decreases in malonyl-CoA, which is the precursor for the tricyclic aromatic quinone biosynthesis pathway. In addition, anti-inflammatory activity was enhanced in extracts of SA-treated adventitious roots. Our results suggest that SA has an important role in activation of the plant specific-type III polyketide biosynthetic pathway, and therefore that the efficacy of Aloe vera as medicinal agent can be improved through SA treatment.

Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice.

Science.gov (United States)

Lee, Dajeong; Kim, Hyuk Soon; Shin, Eunju; Do, Seon-Gil; Lee, Chong-Kil; Kim, Young Mi; Lee, Min Bum; Min, Keun Young; Koo, Jimo; Kim, Su Jeong; Nam, Seung Taek; Kim, Hyun Woo; Park, Young Hwan; Choi, Wahn Soo

2018-05-01

An allergic reaction occurs when the immune system overreacts to harmless substance called allergen that gains access to the body. Food allergy is a hypersensitive immune reaction to food proteins and the number of patients with food allergy has recently increased. Aloe Vera is used for wellness and medicinal purposes. In particular, Aloe vera has been reported to enhance immunity. However, the effect of Aloe vera on food allergy is not yet known. In this study, we investigated the effects of processed Aloe vera gel (PAG) containing low molecular weight Aloe polysaccharide (AP) on ovalbumin (OVA)-induced food allergy in mice. Allergic symptoms, rectal temperature, and diarrhea were measured in OVA-induced food allergy mice. Other allergic parameters were also analyzed by RT-PCR, ELISA, flow cytometry, and other biochemical methods. As the results, PAG suppressed the decrease of body temperature, diarrhea, and allergic symptoms in OVA-induced food allergy mice. PAG also reduced serum concentrations of type 2 helper T cell (Th2) cytokines (Interleukin-(IL)-4, IL-5, and IL-13) as well as histamine, mast cell protease-1 (MCP-1), and immunoglobulin (Ig)E. PAG blocked the degranulation of mast cells and infiltration of eosinophils in intestine. Furthermore, PAG suppressed the population of Th2 cells in spleen and mesenteric lymph nodes. PAG also increased the production of IL-10 and population of type 1 regulatory T (Tr1) cells in mice with food allergy. Taken together, our findings suggest that PAG suppressed Th2 immune responses through, at least partially, stimulating the secretion of IL-10 in food allergy mice. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women

OpenAIRE

Tanaka, Miyuki; Misawa,Eriko; Yamauchi,Koji; Abe,Fumiaki; Ishizaki,Chiaki

2015-01-01

Miyuki Tanaka,1 Eriko Misawa,1 Koji Yamauchi,1 Fumiaki Abe,1 Chiaki Ishizaki2 1Functional Food Research Department, Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, 2Ebisu Skin Research Center, Inforward, Inc., Tokyo, Japan Background: Aloe is known for its topical use for treating wounds and burns. Many previous studies reported the healing effects of Aloe vera. However, there are few clinical studies on the effect of orally administered A. vera gel on ...

Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial

Science.gov (United States)

Yeturu, Sravan Kumar; Acharya, Shashidhar; Urala, Arun Sreenivas; Pentapati, Kalyana Chakravarthy

2015-01-01

Objective To evaluate the effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis in orthodontic treatment. Materials and methods A randomized single-center, single-blind, parallel group, controlled trial was conducted among 90 subjects undergoing fixed orthodontic treatment. The subjects were randomly divided into one of the three study groups (Aloe vera, chlorhexidine, chlorine dioxide). Plaque and gingivitis were assessed using modified Silness and Loe Plaque Index and Gingival Index at baseline and at follow-up after 15 days. Paired t-test and ANOVA with post hoc Dunnett test were used. A p-value of <0.05 was considered statistically significant. Results A total of 85 participants completed the study; among them, 40 were male and 45 were female. There was significant reduction in mean plaque and gingival scores in all the 3 groups at follow-up when compared to baseline. A significantly higher reduction (plaque and gingival scores) was found in chlorhexidine when compared with the Aloe vera group. However, no significant difference was seen between chlorhexidine and chlorine dioxide with respect to mean reduction in plaque and gingival scores. Conclusion Chlorine dioxide can be a suitable and economical alternative for chlorhexidine. Further long-term studies are recommended for evaluating their effectiveness. PMID:26937371

Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel

Energy Technology Data Exchange (ETDEWEB)

Grindlay, D.; Reynolds, T.

1986-06-01

The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components. 154 references.

Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes.

Science.gov (United States)

Rajasekaran, Subbiah; Ravi, Kasiappan; Sivagnanam, Karuran; Subramanian, Sorimuthu

2006-03-01

The effect of diabetes mellitus on lipid metabolism is well established. The association of hyperglycaemia with an alteration of lipid parameters presents a major risk for cardiovascular complications in diabetes. Many secondary plant metabolites have been reported to possess lipid-lowering properties. The present study was designed to examine the potential anti-hyperlipidaemic efficacy of the ethanolic extract from Aloe vera leaf gel in streptozotocin (STZ)-induced diabetic rats. 2. Oral administration of Aloe vera gel extract at a dose of 300 mg/kg bodyweight per day to STZ-induced diabetic rats for a period of 21 days resulted in a significant reduction in fasting blood glucose, hepatic transaminases (aspartate aminotransferase and alanine aminotransferase), plasma and tissue (liver and kidney) cholesterol, triglycerides, free fatty acids and phospholipids and a significant improvement in plasma insulin. 3. In addition, the decreased plasma levels of high-density lipoprotein-cholesterol and increased plasma levels of low-density lipoprotein-and very low-density lipoprotein-cholesterol in diabetic rats were restored to near normal levels following treatment with the extract. 4. The fatty acid composition of the liver and kidney was analysed by gas chromatography. The altered fatty acid composition in the liver and kidney of diabetic rats was restored following treatment with the extract. 5. Thus, the results of the present study provide a scientific rationale for the use of Aloe vera as an antidiabetic agent.

Mosquitocidal and water purification properties of Cynodon dactylon, Aloe vera, Hemidesmus indicus and Coleus amboinicus leaf extracts against the mosquito vectors.

Science.gov (United States)

Arjunan, Nareshkumar; Murugan, Kadarkarai; Madhiyazhagan, Pari; Kovendan, Kalimuthu; Prasannakumar, Kanagarajan; Thangamani, Sundaram; Barnard, Donald R

2012-04-01

Ethanolic extracts of Cynodon dactylon, Aloe vera, Hemidesmus indicus and Coleus amboinicus were tested for their toxicity effect on the third-instar larvae of Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti. The leaves of C. dactylon, A. vera, H. indicus and C. amboinicus were collected from natural habitats (forests) in Western Ghats, Tamil Nadu, India. A total of 250 g of fresh, mature leaves were rinsed with distilled water and dried in shade. The dried leaves were put in Soxhlet apparatus and extract prepared using 100% ethanol for 72 h at 30-40°C. Dried residues were obtained from 100 g of extract evaporated to dryness in rotary vacuum evaporator. Larvicidal properties of ethanolic leaf extracts showed that the extracts are effective as mosquito control agents. The larval mortality was observed after 24 h exposure. No mortality was observed in the control. The median lethal concentration (LC(50)) values observed for the larvicidal activities are 0.44%, 0.51%, 0.59% and 0.68% for extracts of C. dactylon, A. vera, H. indicus and C. amboinicus, respectively. The observed mortality were statistically significant at P < 0.05 level. C. dactylon showed the highest mortality rate against the three species of mosquito larvae in laboratory and field. The selected plants were shown to exhibit water purification properties. Water quality parameters such as turbidity, pH and water clarity were analyzed in the water samples (pre-treatment and post-treatment of plant extracts) taken from the different breeding sites of mosquitoes. Water colour, turbidity and pH were reduced significantly after treatment with C. dactylon (13 HU, 31.5 mg/l and 6.9), H. indicus (13.8 HU, 33 mg/l and 7.1), A. vera (16 HU, 33.8 mg/l and 7.4) and C. amboinicus (21 HU, 35 mg/l and 7.5) extracts. The study proved that the extracts of C. dactylon, A. vera, H. indicus and C. amboinicus have both mosquitocidal and water sedimentation properties.

Elimination of browning exudate and in vitro development of shoots in Pistacia vera L. cv. mateur and Pistacia atlantica Desf. Culture

Directory of Open Access Journals (Sweden)

M. I. Trujillo

2014-01-01

Full Text Available We report diminution and/or elimination of browning exudate followed by in vitro establishment of in Pistacia vera cv. mateur and Pistacia atlantica explants. Soaking P. vera cv. mateur explants prior to culture in L-cysteine HCl for 15 min (100 µM inhibits blackening of the modified Murashige and Skoog medium - MS + 400 mg/l NH4NO3 - and of the explants; while shoot formation was increased. The browning in P. vera cv. mateur and P. atlantica explants dissolved when modified MS and Quoirin and Lepoivre - QL.4 - media were supplemented with activated charcoal (from 1 to 3 g l-1 and with 4 and 8 days of darkness. These treatments were enough to eliminate browning from the explants and to improve the shoots elongation, but symptoms of chlorosis were detected. On the other hand, AgNO3 (from 15 to 40 µ1V1 showed a very strong antibrowning effect on the medium and explants of P. atlantica. Thus shoot organogenesis was best achieved and the developing sturdy shoots had large and green leaves.

Hydroxyurea for Treatment of Nephrotic Syndrome Associated With Polycythemia Vera.

Science.gov (United States)

Hundemer, Gregory L; Rosales, Ivy A; Chen, Yi-Bin; Colvin, Robert B; Tolkoff-Rubin, Nina E

2016-09-01

Myeloproliferative disorders are a rare cause of focal segmental glomerulosclerosis (FSGS), although the mechanism is unclear. Hydroxyurea is commonly used in these disorders for its cytoreductive properties; however, the effect of this treatment on proteinuria or kidney function remains unclear in cases of myeloproliferative disorder-associated FSGS. We describe the clinical course of a patient with polycythemia vera and nephrotic-range proteinuria, demonstrated to have FSGS on biopsy. The patient had a distant history of granulomatosis with polyangiitis (Wegener's), for which he routinely had his kidney function and proteinuria measured, allowing for early detection of nephrotic syndrome soon after being diagnosed with polycythemia vera. Treatment with hydroxyurea resulted in rapid improvement in proteinuria that correlated with a decrease in hematocrit. This response was replicated 2 additional times when the patient was taken off and then restarted on hydroxyurea therapy. He now maintains a steady dose of hydroxyurea with favorable kidney measures (proteinuria with <1g/d of protein excretion and serum creatinine of 1.27mg/dL [corresponding to estimated glomerular filtration rate of 56mL/min/1.73 m(2)]). This case suggests that early screening and treatment for myeloproliferative disorder-associated FSGS may lead to improved long-standing kidney function. Copyright © 2016 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

In Vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications.

Science.gov (United States)

Fox, Lizelle T; du Plessis, Jeanetta; Gerber, Minja; van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H

2014-04-01

To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. Aqueous solutions of the polisaccharidic fractions of the selected aloe leaf gel materials were applied to the volar forearm skin of female subjects. The hydration effect of the aloe gel materials were measured with a Corneometer(®) CM 825, Visioscan(®) VC 98 and Cutometer(®) dual MPA 580 after single and multiple applications. The Mexameter(®) MX 18 was used to determine the anti-erythema effects of the aloe material solutions on irritated skin areas. The A. vera and A. marlothii gel materials hydrated the skin after a single application, whereas the A. ferox gel material showed dehydration effects compared to the placebo. After multiple applications all the aloe materials exhibited dehydration effects on the skin. Mexameter(®) readings showed that A. vera and A. ferox have anti-erythema activity similar to that of the positive control group (i.e. hydrocortisone gel) after 6 days of treatment. The polysaccharide component of the gel materials from selected aloe species has a dehydrating effect on the skin after multiple applications. Both A. vera and A. ferox gel materials showed potential to reduce erythema on the skin similar to that of hydrocortisone gel.

Aloe vera Derived Activated High-Surface-Area Carbon for Flexible and High-Energy Supercapacitors.

Science.gov (United States)

Karnan, M; Subramani, K; Sudhan, N; Ilayaraja, N; Sathish, M

2016-12-28

Materials which possess high specific capacitance in device configuration with low cost are essential for viable application in supercapacitors. Herein, a flexible high-energy supercapacitor device was fabricated using porous activated high-surface-area carbon derived from aloe leaf (Aloe vera) as a precursor. The A. vera derived activated carbon showed mesoporous nature with high specific surface area of ∼1890 m 2 /g. A high specific capacitance of 410 and 306 F/g was achieved in three-electrode and symmetric two-electrode system configurations in aqueous electrolyte, respectively. The fabricated all-solid-state device showed a high specific capacitance of 244 F/g with an energy density of 8.6 Wh/kg. In an ionic liquid electrolyte, the fabricated device showed a high specific capacitance of 126 F/g and a wide potential window up to 3 V, which results in a high energy density of 40 Wh/kg. Furthermore, it was observed that the activation temperature has significant role in the electrochemical performance, as the activated sample at 700 °C showed best activity than the samples activated at 600 and 800 °C. The electron microscopic images (FE-SEM and HR-TEM) confirmed the formation of pores by the chemical activation. A fabricated supercapacitor device in ionic liquid with 3 V could power up a red LED for 30 min upon charging for 20s. Also, it is shown that the operation voltage and capacitance of flexible all-solid-state symmetric supercapacitors fabricated using aloe-derived activated carbon could be easily tuned by series and parallel combinations. The performance of fabricated supercapacitor devices using A. vera derived activated carbon in all-solid-state and ionic liquid indicates their viable applications in flexible devices and energy storage.

Evolutionary history and leaf succulence as explanations for medicinal use in aloes and the global popularity of Aloe vera.

Science.gov (United States)

Grace, Olwen M; Buerki, Sven; Symonds, Matthew R E; Forest, Félix; van Wyk, Abraham E; Smith, Gideon F; Klopper, Ronell R; Bjorå, Charlotte S; Neale, Sophie; Demissew, Sebsebe; Simmonds, Monique S J; Rønsted, Nina

2015-02-26

Aloe vera supports a substantial global trade yet its wild origins, and explanations for its popularity over 500 related Aloe species in one of the world's largest succulent groups, have remained uncertain. We developed an explicit phylogenetic framework to explore links between the rich traditions of medicinal use and leaf succulence in aloes. The phylogenetic hypothesis clarifies the origins of Aloe vera to the Arabian Peninsula at the northernmost limits of the range for aloes. The genus Aloe originated in southern Africa ~16 million years ago and underwent two major radiations driven by different speciation processes, giving rise to the extraordinary diversity known today. Large, succulent leaves typical of medicinal aloes arose during the most recent diversification ~10 million years ago and are strongly correlated to the phylogeny and to the likelihood of a species being used for medicine. A significant, albeit weak, phylogenetic signal is evident in the medicinal uses of aloes, suggesting that the properties for which they are valued do not occur randomly across the branches of the phylogenetic tree. Phylogenetic investigation of plant use and leaf succulence among aloes has yielded new explanations for the extraordinary market dominance of Aloe vera. The industry preference for Aloe vera appears to be due to its proximity to important historic trade routes, and early introduction to trade and cultivation. Well-developed succulent leaf mesophyll tissue, an adaptive feature that likely contributed to the ecological success of the genus Aloe, is the main predictor for medicinal use among Aloe species, whereas evolutionary loss of succulence tends to be associated with losses of medicinal use. Phylogenetic analyses of plant use offer potential to understand patterns in the value of global plant diversity.

Use of dexpanthenol and aloe vera to influence the irradiation response of the oral mucous membrane (mouse); Beeinflussung der Strahlenreaktion der Mundschleimhaut (Maus) durch Dexpanthenol {+-} Aloe vera

Energy Technology Data Exchange (ETDEWEB)

Schlichting, S. [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Dresden Univ. (Germany); Spekl, K.; Doerr, W. [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Dresden Univ. (Germany)]|[Experimentelles Zentrum, Medizinische Fakultaet Carl Gustav Carus, Dresden Univ. (Germany)

2004-07-01

In summarising the outcome of the present study it can be said spraying the agent on the oral mucous membrane once a day had an effect on the incidence of mucous membrane ulceration in the case of both placebo and dexpanthenol treatment. However, there was no significant difference between placebo and dexpanthenol treatment, the only finding being a slight prolongation of latency time through aloe vera. These experimental findings give good reason to critically reconsider the clinical use of dexpanthenol as a supportive treatment for the prevention of radiogenic mucositis enoralis following irradiation of tumours in the head and neck region. However thorough oral lavage is an effective means of moderating the irradiation response of the oral mucous membrane. [German] Zusammenfassend ist festzustellen, dass in den vorliegenden Versuchen mit einmal taeglichem Aufspruehen des Praeparates auf die Mundschleimhaut sowohl die Placebo - wie auch die Dexpanthenol-Behandlung die Inzidenz von Schleimhautulzerationen modifiziert hat; zwischen Placebo- und Dexpanthenol-Behandlung ergab sich jedoch kein signifikanter Unterschied. Lediglich eine geringe Verlaengerung der Latenzzeit durch Aloe vera war zu beobachten. Auf der Basis dieser experimentellen Ergebnisse muss der klinische Einsatz von Dexpanthenol im Rahmen der Supportivtherapie zur Prophylaxe der radiogenen Mucositis enoralis bei der Bestrahlung von Kopf-Hals-Tumoren kritisch ueberdacht werden. Regelmaessige, intensive Mundspuelungen sind jedoch ein probates Mittel zur Verminderung der Strahlenreaktion der Mundschleimhaut. (orig.)

The Effect of Aloe vera Extract on Adherence of Candida albicans and Other Properties of Heat Cure Denture Soft Lining Material

Directory of Open Access Journals (Sweden)

Aseel Riyadh Abdulwahhab

2018-03-01

Full Text Available Objective: One of the serious drawbacks of denture soft lining materials is colonization by Candida albicans that might eventually leads to denture stomatitis. This can be treated either systemically or locally. With the recent increase interest in medicinal plants, this study aimed to evaluate the effect of Aloe vera powder incorporated with heat cure acrylic soft-liner powder on the adherence of Candida albicans, shear bond strength and tear strength. Methods: According to the results of pilot study, two percentages (3% and 10% of aloe vera powder was used. Candida adherence test, shear bond strength and tear strength tests were performed, also the long-term effect was evaluated after 2 and 4 weeks incubation in artificial saliva. All data was analyzed using SPSS software (version 24. Descriptive and inferential statistics, ANOVA test with post-hoc analysis was applied. Results: The results indicated that both concentrations of aloe vera showed a statistically highly significant decrease in Candida albicans cell count in comparison to control group, also a significant increase in shear bond strength and non-significant difference in tear strength of soft liner for the experimental groups. After 2 and 4 weeks incubation in artificial saliva, all experimental groups showed a statistically significant decrease in Candida albicans cell count and a statistically significant increase in shear bond strength and tear strength test. Conclusion: Incorporation of aloe vera powder with heat cure acrylic soft-liner powder helps to add an anti-candidal property to the soft liner, also this addition results in improvement in shear bond strength and tear strength.

Polycythemia vera: the natural history of 1213 patients followed for 20 years. Gruppo Italiano Studio Policitemia.

Science.gov (United States)

1995-11-01

To reassess the natural history of polycythemia vera and to obtain reliable estimates of both incidence of thrombosis and survival for use in defining the sample size for therapeutic clinical trials. Retrospective cohort study of patients with polycythemia who had been followed for 20 years. 11 Italian hematology institutions. 1213 patients with polycythemia vera, which was diagnosed according to criteria established by the Polycythemia Vera Study Group and commonly used in clinical practice. All-cause mortality, venous and arterial thrombosis, and hematologic and nonhematologic neoplastic disease. Myocardial infarction and stroke were classified as major thrombotic events, and venous and peripheral arterial thrombosis were considered minor thrombotic events. The number of patients who died and the number of those who had major thrombotic events (combined end point) were used as a comprehensive measure of the benefit-risk ratio associated with the use of myelosuppressive agents. 634 fatal and nonfatal arterial and venous thromboses were recorded in 485 patients (41%); 36% of these episodes occurred during follow-up in 230 patients (19%), and 64% occurred either at presentation or before diagnosis. Thrombotic events occurred more frequently in the 2 years preceding diagnosis, suggesting a causal relation between the latent myeloproliferative disorder and the vascular event. The incidence of thrombosis during follow-up was 3.4%/y; older patients or those with a history of thrombosis had a higher risk for thrombosis. Overall mortality was 2.9/100 patients per year; thrombotic events and hematologic or nonhematologic cancers had similar effects on mortality. Patients receiving chemotherapy died three to four times more frequently than those not receiving chemotherapy. The increased risk for cancer in patients receiving myelosuppressive agents was seen approximately 6 years after diagnosis. In addition, the combined end point, computed as the sum of the hardest

Investigation on structural properties of M-type strontium hexaferrite synthesized in presence of neem and aloe-vera plant leaves extract

Science.gov (United States)

Solanki, Neha; Jotania, Rajshree B.

2017-05-01

M-type strontium hexaferrite powder samples were synthesized using a green synthesis route with and without presence of Aloe vera and Neem leaves extract. The dry brownish precursors of strontium hexaferrite were recovered from a mixed solution of metal salts and leaves extract, heated at 100 °C. The obtained precursors were pre-heated at 500 °C for 4 hrs. followed by final heating at 950 °C for 4 hrs. in a muffle furnace to obtain SrFe12O19 hexaferrite powder. The obtained SrFe12O19 hexaferrite powder samples characterized at room temperature in order to check phase purity and structural properties. XRD analysis confirms that samples prepared without and with Aloe vera leaves extract (heated at 950 °C for 4 hrs.) show formation of α-Fe2O3 and M-phase; while the sample prepared in presence of Neem leaves extract (heated at 950 °C for 4 hrs.) show formation of mono phase of strontium hexaferrite. Lattice parameter (a) and cell volume (V) are found to increase in the samples prepared in presence of Aloe vera and Neem leaves extract.

Vera Poska-Grünthal - Eesti riigimehe tütar ja naisõiguslane / Kairi Ilison

Index Scriptorium Estoniae

Ilison, Kairi

2010-01-01

Riigivanema ja poliitiku Jaan Poska tütrest Vera Poska-Grünthalist (1898-1986), kes oli tuntud ajakirjanik ja naisõiguslane. Põgenes Teise maailmasõja ajal Rootsi ja asutas seal 1952. aastal ajakirja "Triinu", mis lõpetas ilmumise Torontos 1995. aastal, olles Eesti naiste ühendaja vabas maailmas

Astrometry of red supergiant VY Canis Majoris with VERA

Science.gov (United States)

Choi, Y. K.; Hirota, T.; Honma, M.; Kobayashi, H.

2008-07-01

We present observational results on the red supergiant VY Canis Majoris with VERA. We have observed 22 GHz H2O masers and 43 GHz SiO masers (v=1 and 2 J=1-0) around VY CMa for 13 months. We succesfully detected a parallax of 0.87 ± 0.08 mas, corresponding to the distance of 1.15 +0.10-0.09 kpc using H2O masers. As the result of phase-referencing analyses, we have measured absolute positions for both H2O masers and SiO masers. The H2O maser features show rapid expansion off the central star.

Burning feet in polycythemia vera – peripheral sensorimotor axonal neuropathy with erythromelalgia

Directory of Open Access Journals (Sweden)

Wollina U

2015-02-01

Full Text Available Uwe Wollina Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Germany Abstract: Polycythemia vera is a rare myeloproliferative disease. Cutaneous symptoms are uncommon. We report about a 72-year-old female patient with JAK2V617F-positive polycythemia who developed peripheral sensorimotor axonal neuropathy and erythromelalgia. Possible causes and treatment are discussed. Keywords: bone marrow diseases, myeloproliferative diseases, JAK2 mutations, burning sensations, peripheral neuropathy

Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat.

Science.gov (United States)

Tabandeh, Mohammad Reza; Oryan, Ahmad; Mohammadalipour, Adel

2014-04-01

Polysaccharides are the main macromolecules of Aloe vera gel but no data about their effect on extracellular matrix (ECM) elements are available. Here, mannose rich Aloe vera polysaccharides (AVP) with molecular weight between 50 and 250 kDa were isolated and characterized. Open cutaneous wounds on the back of 45 rats (control and treated) were daily treated with 25mg (n=15) and 50 mg (n=15) AVP for 30 days. The levels of MMP-3 and TIMP-2 gene expression were analyzed using real time PCR. The levels of n-acetyl glucosamine (NAGA), n-acetyl galactosamine (NAGLA) and collagen contents were also measured using standard biochemical methods. Faster wound closure was observed at day 15 post wounding in AVP treated animals in comparison with untreated group. At day 10 post wounding, AVP inhibited MMP-3 gene expression, while afterwards MMP-3 gene expression was upregulated. AVP enhanced TIMP-2 gene expression, collagen, NAGLA and NAGA synthesis in relation to untreated wounds. Our results suggest that AVP has positive effects on the regulation of ECM factor synthesis, which open up new perspectives for the wound repair activity of Aloe vera polysaccharide at molecular level. Copyright © 2014 Elsevier B.V. All rights reserved.

Prophylactic role of Aloe vera against radiation and cadmium induced histological alterations in the kidney of Swiss albino mice

International Nuclear Information System (INIS)

Chakravarti, A.; Prajapat, T.R.; Ojha, S.; Kanwar, Om; Nayak, K.; Ram, Purkha; Bhartiya, K.M.; Gupta, M.L.; Jangir, A.

2012-01-01

Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure of radiation. Thus, development of novel and effective approaches using non toxic radioprotectors is of considerable interest for not only in the protection of normal tissue during radio therapy of tumors but also for defence (nuclear wars), nuclear industries, radiation accidents, space flights etc. Adult male Swiss albino mice were exposed to 5.0 Gy gamma radiations in the presence or absence of the Aloe vera. For this purpose 6 to 8 week old male mice were divided into seven groups; group I (sham-irradiated), group II (cadmium chloride), group III (irradiated with 5Gy. Gamma rays), group IV (radiation and cadmium chloride), group V (cadmium chloride and Aloe vera), group VI (radiation and Aloe vera), group VII (radiation, cadmium chloride and Aloe vera). Animals from all the above groups were autopsied at 1, 2, 4, 7, 14 and 28 days post treatment intervals. For histopathological studies kidney was taken out and it's pieces were fixed in Bouins fixative for 24 hours. The tissue was washed in clean water to remove excess of the fixative, dehydrated in graded series of alcohol, cleared in xylene and embedded in paraffin wax. Sections were cut at 5 μm and stained in Harris haematoxyline and alcoholic eosine. In the present experiment histopathological changes were found in the kidney of Swiss albino mice. Severe changes seen in the renal architecture after exposure of 5 Gy of gamma rays were: blurred renal architecture, intracellular oedema, damaged tubules, cytoplasmic degranulation, vacuolation and pycnotic nuclei in the cortical and medullary part. The changes were more marked on day 7, but on day 14 the signs of recovery were observed and on day 28 comparatively better renal architecture was observed. In cadmium chloride treated animals the changes observed were: cytoplasmic degranulation, vacuolation, crenated and pycnotic nuclei. The

CD177: A member of the Ly-6 gene superfamily involved with neutrophil proliferation and polycythemia vera

Directory of Open Access Journals (Sweden)

Bettinotti Maria

2004-03-01

Full Text Available Abstract Genes in the Leukocyte Antigen 6 (Ly-6 superfamily encode glycosyl-phosphatidylinositol (GPI anchored glycoproteins (gp with conserved domains of 70 to 100 amino acids and 8 to 10 cysteine residues. Murine Ly-6 genes encode important lymphocyte and hematopoietic stem cell antigens. Recently, a new member of the human Ly-6 gene superfamily has been described, CD177. CD177 is polymorphic and has at least two alleles, PRV-1 and NB1. CD177 was first described as PRV-1, a gene that is overexpressed in neutrophils from approximately 95% of patients with polycythemia vera and from about half of patients with essential thrombocythemia. CD177 encodes NB1 gp, a 58–64 kD GPI gp that is expressed by neutrophils and neutrophil precursors. NB1 gp carries Human Neutrophil Antigen (HNA-2a. Investigators working to identify the gene encoding NB1 gp called the CD177 allele they described NB1. NB1 gp is unusual in that neutrophils from some healthy people lack the NB1 gp completely and in most people NB1 gp is expressed by a subpopulation of neutrophils. The function of NB1 gp and the role of CD177 in the pathogenesis and clinical course of polycythemia vera and essential thrombocythemia are not yet known. However, measuring neutrophil CD177 mRNA levels has become an important marker for diagnosing the myeloproliferative disorders polycythemia vera and essential thrombocythemia.

Polycythemia vera presenting with left hemichoreiform movements. A case report

Energy Technology Data Exchange (ETDEWEB)

Mori, Tamiharu; Shimomura, Chikako; Ishibashi, Hiroshi; Tsujihata, Mitsuhiro; Nagataki, Shigenobu

1985-01-01

A 65-year-old man developed abruptly choreiform movements involving the left face, arm and leg one day prior to admission. Physical examination revealed red face and palms, hyperemic conjunctivae and atrial fibrillations. Blood pressure was 168/90. Spleen was not palpable. Hemichoreiform movements of the left face and limbs were observed. There was no other neurological abnormalities. Laboratory studies showed RBC 880 x 10U, Hb 22.4g/dl, Hct 63%, WBC 8,100, platelets 22.9 x 10U, ESR 0mm/hr, RBC oxygen saturation 97%, serum iron 67 g/dl, LDH 593 units, uric acid 14mg/dl, and erythropoietine (HI method) 19mIU/ml (normal 28-88). Bone marrow showed myeloid nucleated cell count 38.6 x 10U. ECG showed atrial fibrillations. Chest X-ray and scintigrams of liver and spleen were normal. CSF was normal. Brain CT scan on admission disclosed a low density area in right caudate nucleus. The choreiform movements were rapidly mitigated by venesection and by oral administration of haloperidol(3mg daily). There weeks after discontinuing haloperidol, the hemichorea returned. The routine hematology showed RBC 870 x 10U, Hb 19.8g/dl, Hct 62%, WBC 10,200, and plateret 37.4 x 10U. Another venesection reduced the chorea. Pipobroman was administered to control the polycythemia vera. He has been free of choreic movements thereafter. Choreiform movement is rarely observed in polycythemia vera. The pathogenesis is still unknown. The venous congestion, however, may play a role in this case because the choreic movements disappeared by venesection. (author).

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na{sup 99m}TcO{sub 4}) in rats

Energy Technology Data Exchange (ETDEWEB)

Holanda, Cecilia Maria de Carvalho Xavier [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Dept. of Microbiology and Parasitology. Experimental Radiobiology and Antiparasitic Assays Lab.], e-mail: cechol@ufrnet.br; Costa, Monique Batista da; Silva, Natalia Chilinque Zambao da; Silva Junior, Mauricio Ferreira da; Barbosa, Vanessa Santos de Arruda; Silva, Roseane Pereira da [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil); Medeiros, Aldo da Cunha [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil). Nucleus of Experimental Surgery

2009-07-01

Purpose: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na{sup 99m}TcO{sub 4} and laboratorial parameters in Wistar rats. Methods: twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na{sup 99m}TcO{sub 4} by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (% ATI/g) was determined. Biochemical dosages were performed. Results: there was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p<0.05). Conclusion: The aqueous extract of Aloe vera facilitated the uptake of Na{sup 99m}TcO{sub 4} in organs of rats and it was responsible to a high increase of levels of AST and ALT. (author)

In Vivo skin hydration and anti-erythema effects of Aloe vera, Aloe ferox and Aloe marlothii gel materials after single and multiple applications

Science.gov (United States)

Fox, Lizelle T.; du Plessis, Jeanetta; Gerber, Minja; van Zyl, Sterna; Boneschans, Banie; Hamman, Josias H.

2014-01-01

Objective: To investigate the skin hydrating and anti-erythema activity of gel materials from Aloe marlothii A. Berger and A. ferox Mill. in comparison to that of Aloe barbadensis Miller (Aloe vera) in healthy human volunteers. Materials and Methods: Aqueous solutions of the polisaccharidic fractions of the selected aloe leaf gel materials were applied to the volar forearm skin of female subjects. The hydration effect of the aloe gel materials were measured with a Corneometer® CM 825, Visioscan® VC 98 and Cutometer® dual MPA 580 after single and multiple applications. The Mexameter® MX 18 was used to determine the anti-erythema effects of the aloe material solutions on irritated skin areas. Results: The A. vera and A. marlothii gel materials hydrated the skin after a single application, whereas the A. ferox gel material showed dehydration effects compared to the placebo. After multiple applications all the aloe materials exhibited dehydration effects on the skin. Mexameter® readings showed that A. vera and A. ferox have anti-erythema activity similar to that of the positive control group (i.e. hydrocortisone gel) after 6 days of treatment. Conclusion: The polysaccharide component of the gel materials from selected aloe species has a dehydrating effect on the skin after multiple applications. Both A. vera and A. ferox gel materials showed potential to reduce erythema on the skin similar to that of hydrocortisone gel. PMID:24991119

Dietary aloe vera gel powder and extract inhibit azoxymethane- induced colorectal aberrant crypt foci in mice fed a high- fat diet.

Science.gov (United States)

Chihara, Takeshi; Shimpo, Kan; Kaneko, Takaaki; Beppu, Hidehiko; Higashiguchi, Takashi; Sonoda, Shigeru; Tanaka, Miyuki; Yamada, Muneo; Abe, Fumiaki

2015-01-01

Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

Rosmarinic acid and antioxidant enzyme activities in Lavandula vera MM cell suspension culture: a comparative study.

Science.gov (United States)

Georgiev, Milen; Abrashev, Radoslav; Krumova, Ekaterina; Demirevska, Klimentina; Ilieva, Mladenka; Angelova, Maria

2009-11-01

The growth and intracellular protein content of lavender (Lavandula vera MM) cell suspension culture was followed along with some antioxidant defense system members-non-enzymatic (rosmarinic acid) and enzymatic [superoxide dismutase (EC 1.15.1.1) and catalase (EC 1.11.1.6)]. It was found that the media content and the cultivation mode strongly influenced the production of plant defense compounds as well as the ratio between non-enzymatic and enzymatic ones. The bioreactor culture contains about two times more rosmarinic acid, superoxide dismutase, and catalase compared to the shake-flask cultivation. These findings are discussed with respect to the relative stress levels and plant antioxidant orchestra system. It was concluded that investigated defense system components (enzymatic and non-enzymatic) were closely associated in a complex balance. The three isoenzyme forms of SOD (Cu/ZnSOD, FeSOD, and MnSOD) in the cells of Lavandula vera were revealed by polyacrylamide gel electrophoresis analysis, and the FeSOD isoform exhibited highest activity.

Dietary Aloe vera components' effects on cholesterol lowering and estrogenic responses in juvenile goldfish, Carassius auratus.

Science.gov (United States)

Palermo, Francesco A; Cocci, Paolo; Angeletti, Mauro; Felici, Alberto; Polzonetti-Magni, Alberta Maria; Mosconi, Gilberto

2013-08-01

Aloes are now considered a very interesting source of bioactive compounds among which phytosterols should play a major role. The present study is an attempt to investigate the hypocholesterolemic activity of Aloe vera associated with its impact on the reproductive status of juvenile goldfish. Therefore, the short- and long-term effects of feeding supplementary diet containing aloe components (20 mg aloe/g diet; 2%) on plasma lipids, plasma vitellogenin, and hepatic estrogen receptor α/β1 mRNA levels in goldfish were examined. Results of GC-MS for phytosterols show high abundance of β-sitosterol in freeze-dried powder of Aloe vera whole leaves. Moreover, a 2% aloe powder dietary supplement was not found estrogenic in juvenile goldfish after either 7- or 30-day treatment, but was consistent in plasma hypocholesterolemic effects following long-term exposure. The present data further support that plasma cholesterol modulation induced by phytosterols may not be related to estrogen-like activity.

Mosquitocidal and antibacterial activity of green-synthesized silver nanoparticles from Aloe vera extracts: towards an effective tool against the malaria vector Anopheles stephensi?

Science.gov (United States)

Dinesh, Devakumar; Murugan, Kadarkarai; Madhiyazhagan, Pari; Panneerselvam, Chellasamy; Kumar, Palanisamy Mahesh; Nicoletti, Marcello; Jiang, Wei; Benelli, Giovanni; Chandramohan, Balamurugan; Suresh, Udaiyan

2015-04-01

Mosquitoes represent an important threat for lives of millions of people worldwide, acting as vectors for devastating pathogens, such as malaria, yellow fever, dengue, and West Nile. In addition, pathogens and parasites polluting water also constitute a severe plague for populations of developing countries. Here, we investigated the mosquitocidal and antibacterial properties of Aloe vera leaf extract and silver nanoparticles synthesized using A. vera extract. Mosquitocidal properties were assessed in laboratory against larvae (I-IV instar) and pupae of the malaria vector Anopheles stephensi. Green-synthesized silver nanoparticles were tested against An. stephensi also in field conditions. Antibacterial properties of nanoparticles were evaluated against Bacillus subtilis, Klebsiella pneumoniae, and Salmonella typhi using the agar disk diffusion and minimum inhibitory concentration protocol. The synthesized silver nanoparticles were characterized by UV-vis spectrum, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In laboratory conditions, the A. vera extract was toxic against An. stephensi larvae and pupae, even at low dosages. LC50 were 48.79 ppm (I instar), 59.09 ppm (II instar), 70.88 ppm (III instar), 83.58 ppm (IV instar), and 152.55 ppm (pupae). Green-synthesized silver nanoparticles were highly toxic against An. stephensi. LC50 were 3.825 ppm (I instar), 4.119 ppm (II instar), 4.982 ppm (III instar), 5.711 ppm (IV instar), and 6.113 ppm (pupae). In field conditions, the application of A. vera-synthesized silver nanoparticles (10 × LC50) leads to An. stephensi larval reduction of 74.5, 86.6, and 97.7%, after 24, 48, and 72 h, respectively. Nanoparticles also showed antibacterial properties, and the maximum concentration tested (150 mg/L) evoked an inhibition zone wider than 80 mm in all tested bacterium species. This study adds knowledge about the use of green synthesis of nanoparticles in

Sustained major molecular response on interferon alpha-2b in two patients with polycythemia vera

DEFF Research Database (Denmark)

Larsen, T.S.; Pallisgaard, N.; Andersen, M.T.

2008-01-01

with a JAK2 V617F allele burden below 1.0% in two patients with polycythemia vera treated with interferon alpha-2b (IFN-2b). Discontinuation of IFN-2b in one of the patients was followed by a sustained long-lasting (12 months of follow-up) major molecular response Udgivelsesdato: 2008/10...

EL ALOE VERA (ALOE BARBADENSIS MILLER) COMO COMPONENTE DE ALIMENTOS FUNCIONALES

OpenAIRE

Vega G, Antonio; Ampuero C, Nevenka; Díaz N, Luis; Lemus M, Roberto

2005-01-01

Debido a la preocupación e interés actual de la población por las condiciones de salud y calidad de vida, es que ha aumentado la demanda de productos naturales, lo cual hace que las industrias farmacéuticas y de los alimentos centren sus esfuerzos en investigaciones relacionadas con su utilización. Una de las materias primas de gran demanda, tanto en el mercado externo como en el nacional, es el Aloe vera, vegetal del cual se pueden obtener productos con fines cosmetológicos, farmacéuticos y ...

Physicochemical Properties of MTA and Portland Cement after Addition of Aloe Vera.

Science.gov (United States)

Henrique Borges, Alvaro; Aguirre Guedes, Orlando; Evaristo Ricci Volpato, Luiz; Siebert Filho, Gilberto; Meireles Borba, Alexandre; Zina, Omar; Piva, Evandro; Estrela, Carlos

2017-01-01

The aim of this in vitro study was to determine the liquid-powder ratio, setting time, solubility, dimensional change, pH, and radiopacity of white structural and non-structural Portland cement, ProRoot MTA and MTA Bio, associated with a 2% glycolic solution containing Aloe Vera, as vehicle. Five samples of each material were used for each test, according to the American National Standards Institute/American Dental Association (ANSI/ADA) specification No. 57. Statistical analyses were performed using ANOVA and Tukey's test at 5% significance. When sample distribution was not normal, non-parametric analysis of variance and the Kruskal-Wallis test were used ( α =0.05). No statistical differences were found in liquid-powder ratios among the tested materials. ProRoot MTA showed the longest setting time. Dimensional change values were acceptable in all groups. Also, no significant differences were found in pH values and pH was alkaline in all samples throughout the experiment. Mean radiopacity results obtained for white Portland cements did not meet ANSI/ADA requirements, and were significantly lower than those obtained for MTA-based cements. Finally, Portland cements showed significantly higher mean solubility values compared to the other samples. The physicochemical properties of the tested materials in association with Aloe Vera were compatible with ANSI/ADA requirements, except for the white Portland cements, which failed to meet the radiopacity specification.

Bioassay-guided evaluation of anti-inflammatory and antinociceptive activities of pistachio, Pistacia vera L.

Science.gov (United States)

Orhan, I; Küpeli, E; Aslan, M; Kartal, M; Yesilada, E

2006-04-21

The ethanolic and aqueous extracts prepared from different parts of Pistacia vera L. (Anacardiaceae) as well as its oleoresin were evaluated for their in vivo anti-inflammatory and antinociceptive activities. Among the extracts screened, only the oleoresin was shown to possess a marked anti-inflammatory activity against carrageenan-induced hind paw edema model in mice without inducing any gastric damage at both 250 and 500 mg/kg doses whereas the rest of the extracts were totally inactive. While the oleoresin was found to display significant antinociceptive activity at 500 mg/kg dose, the ethanolic and aqueous extracts belonging to fruit, leaf, branch and peduncle of Pistacia vera did not exhibit any noticeable antinociception in p-benzoquinone-induced abdominal contractions in mice. Fractionation of the oleoresin indicated the n-hexane fraction to be active, which further led to recognition of some monoterpenes, mainly alpha-pinene (77.5%) by capillary gas chromatography-mass spectrometry (GC-MS) as well as the oleoresin itself. alpha-Pinene was also assessed for its antinociceptive and anti-inflammatory activities in the same manner and exerted a moderate anti-inflammatory effect at 500 mg/kg dose.

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice.

Science.gov (United States)

El-Batal, Ahmed Ibrahim; Ahmed, Salwa Farid

2018-02-05

Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.

Hernán Vera Lamperein y su participación en el movimiento de renovacion gradual de la educación secundária en Chile - Hernan Vera Lamperein and his participation in the movement of gradual renewal of secondary education in Chile

Directory of Open Access Journals (Sweden)

Jaime Caiceo Escudero, Chile

2014-01-01

Full Text Available Este trabalho tem como objetivos fundamentais destacar os principais traços biográficos de Hernán Vera Lamperein, Prêmio em Educação 2001, e descrever sua participação em uma das principais reformas educacionais que tomaram impulso no Chile entre 1945 e 1953, como parte do Movimento de Renovação Gradual da Educação Secundária. A metodologia utilizada é própria das pesquisas históricas: recorreu-se à fontes primárias e secundárias, foram feitas entrevistas com o personagem, bem como com pessoas que o conheceram, foram analisadas suas publicações e revisada a documentação dos lugares onde desempenhou seu trabalho profissional.Palavras-chave: reforma educacional, pedagogia de Dewey, prêmios nacionais em educação.HERNAN VERA LAMPEREIN AND HIS PARTICIPATION IN THE MOVEMENT OF GRADUAL RENEWAL OF SECONDARY EDUCATION IN CHILEAbstractThis work has as main objectives: to indicate the key biographical characteristics of Hernan Vera Lamperein, National Education Award 2001, and to describe their participation in one of the most important education reforms that took place between 1945 and1953 inChile as part of the Movement of gradual renewal of secondary education in Chile. The methodology used is typical of historical studies; It has been based on primary and secondary sources; interviews were given by the protagonist himself and by people who meet him, at the same time, bibliographical revision was made in order to analyze his works and professional life.Key-words: educational reform, Dewey´s pedagogy, national awards in education.HERNÁN VERA LAMPEREIN Y SU PARTICIPACIÓN EN EL MOVIMIENTO DE RENOVACION GRADUAL DE LA EDUCACIÓN SECUNDARIA EN CHILE ResumenEste trabajo tiene como objetivos fundamentales: señalar los principales rasgos biográficos de Hernán Vera Lamperein, Premio Nacional de Educación 2001, y describir su participación en una de las principales reformas educacionales que se impulsaron entre 1945 y 1953 en

Effect of Heat Shock Treatment and Aloe Vera Coating to Chilling Injury Symptom in Tomato (Lycopersicon asculantum Mill.

Directory of Open Access Journals (Sweden)

Sutrisno

2012-04-01

Full Text Available This research was undertaken to determine the effect of length in heat shock and edible coating as pre-storage treatment to Chilling Injury (CI symptom reflected by ion leakage induced and quality properties in tomato (Lycopersicon asculantum Mill.. Heat Shock Treatment (HST was conducted at three different levels of length, which were, 20; 40 and 60 min. Edible coating was conducted using aloe vera gel. The result showed that HST and Aloe Vera Coating (AVC were more effective to reduce CI symptom at lower chilling storage. Prolong exposure to heated water may delay climacteric peak. The length of heat shock, AVC treatment and low temperature storage significantly affected the tomato quality parameter but not significantly different for each treatment except weight loss. HST for 20 min at ambient temperature was significantly different to other treatment.

Mosquitocidal and water purification properties of Cynodon dactylon, Aloe vera, Hemidesmus indicus and Coleus amboinicus leaf extracts.

Science.gov (United States)

Ethanolic extracts of Cynodon dactylon, Aloe vera, Hemidesmus indicus and Coleus amboinicus were tested for toxicity to 3rd instar Anopheles stephensi, Culex quinquefasciatus, and Aedes aegypti. Median lethal concentrations (LC50) were, respectively, 0.44%, 0.51%, 0.59% and 0.68%. Cynodon dactylon...

Clear Evidence of Carcinogenic Activity by a Whole-Leaf Extract of Aloe barbadensis Miller (Aloe vera) in F344/N Rats

Science.gov (United States)

Boudreau, Mary D.

2013-01-01

Aloe barbadensis Miller (Aloe vera) is an herbal remedy promoted to treat a variety of illnesses; however, only limited data are available on the safety of this dietary supplement. Drinking water exposure of F344/N rats and B6C3F1 mice to an Aloe vera whole-leaf extract (1, 2, and 3%) for 13 weeks resulted in goblet cell hyperplasia of the large intestine in both species. Based upon this observation, 2-year drinking water studies were conducted to assess the carcinogenic potential of an Aloe vera whole-leaf extract when administered to F344/N rats (48 per sex per group) at 0.5, 1, and 1.5%, and B6C3F1 mice (48 per sex per group) at 1, 2, and 3%. Compared with controls, survival was decreased in the 1.5% dose group of female rats. Treatment-related neoplasms and nonneoplastic lesions in both species were confined primarily to the large intestine. Incidences of adenomas and/or carcinomas of the ileo-cecal and cecal-colic junction, cecum, and ascending and transverse colon were significantly higher than controls in male and female rats in the 1 and 1.5% dose groups. There were no neoplasms of the large intestine in mice or in the 0 or 0.5% dose groups of rats. Increased incidences of mucosa hyperplasia of the large intestine were observed in F344/N rats, and increased incidences of goblet cell hyperplasia of the large intestine occurred in B6C3F1 mice. These results indicate that Aloe vera whole-leaf extract is an intestinal irritant in F344/N rats and B6C3F1 mice and a carcinogen of the large intestine in F344/N rats. PMID:22968693

Tyrosinase inhibitory components from Aloe vera and their antiviral activity.

Science.gov (United States)

Kim, Jang Hoon; Yoon, Ju-Yeon; Yang, Seo Young; Choi, Seung-Kook; Kwon, Sun Jung; Cho, In Sook; Jeong, Min Hee; Ho Kim, Young; Choi, Gug Seoun

2017-12-01

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC 50 value of 9.8 ± 0.9 µM. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

THE EFFECTS OF IL-1 AND IL-4 ON THE EPO-INDEPENDENT ERYTHROID PROGENITOR IN POLYCYTHEMIA-VERA

NARCIS (Netherlands)

DEWOLF, JTM; HENDRIKS, DW; ESSELINK, MT; HALIE, MR; VELLENGA, E

1994-01-01

Human recombinant interleukin-1 (IL-1) was studied for its effects on the erythroid progenitors from normal subjects and from patients with polycythaemia vera (PV). No supportive effect of IL-1 was noticed on the normal, erythropoietin (Epo) dependent, erythroid burst-forming unit (BFU-E) using

Myelosuppression in polycythemia vera: chemotherapy or radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Najean, Y.; Dresch, C.

1982-01-01

The high 10 year life expectancy and the minimization of risk to all types of vascular accidents and evolution towards myelofibrosis argue strongly in favour of myelosuppression by /sup 32/P as the therapy of choice for polycythemia vera. The long term risk of leukemia which is the main argument against this form of treatment can be assessed for the alternative (chemotherapy with Busulphan or Melphelan, combination of hydroxyurea with phlebotomies) only if there is a sufficient follow-up time (at least 10 years) and if the patients followed were treated with only one therapeutic modality during the whole period. For this reason only cooperative protocols designed for long periods of application and follow-up can resolve the questions posed. Further, it is essential in such studies that the therapeutic results are assessed not only in terms of the survival of the patients but also in terms of the quality of their lives following the various forms of treatment.

Whatever Happened to Vera?

Directory of Open Access Journals (Sweden)

Jo Henderson

2013-12-01

Full Text Available The road to technological progress is littered with unsuccessful prototypes and their inventors, and in British television there is perhaps no better example than John Logie Baird, universally recognised as the inventor of the technology, but not the successful business model. Another casualty is the Vision Electronic Recording Apparatus (VERA, less well known than Baird’s invention but a technology developed by the BBC Design Unit that has the potential to change the production and working practices of British television, in ways yet to be imagined or apparent. This article, based on secondary sources (Briggs: 1995, Burns:1977,Hall: 1996, Hartney: 1996 Marshall: 1979 Nash: 1970, and Wyver:1981, 1989, seeks to illuminate and narrativise some of the threads in the hidden, or certainly largely unexplored, history of video technology in British television between 1955 and 1975. The start date recognises the ending the BBC’s television monopoly and the shift to a duopolistic industry that the BBC has to adjust to. The end date reflects a point where non-broadcast video technology has become more affordable and of such high quality that it threatens to achieve the standard previously set as the minimum by the broadcasting unions. The affordability of the technology leads to new forms of content and new contexts of practice developing amongst artists, activists and auteurs, some of whom explicitly choose to question the constructs of television.

Risk of thrombosis according to need of phlebotomies in patients with polycythemia vera treated with hydroxyurea

Science.gov (United States)

Alvarez-Larrán, Alberto; Pérez-Encinas, Manuel; Ferrer-Marín, Francisca; Hernández-Boluda, Juan Carlos; Ramírez, María José; Martínez-López, Joaquín; Magro, Elena; Cruz, Yasmina; Mata, María Isabel; Aragües, Pilar; Fox, María Laura; Cuevas, Beatriz; Montesdeoca, Sara; Hernández-Rivas, José Angel; García-Gutiérrez, Valentín; Gómez-Casares, María Teresa; Steegmann, Juan Luis; Durán, María Antonia; Gómez, Montse; Kerguelen, Ana; Bárez, Abelardo; García, Mari Carmen; Boqué, Concepción; Raya, José María; Martínez, Clara; Albors, Manuel; García, Francesc; Burgaleta, Carmen; Besses, Carlos

2017-01-01

Hematocrit control below 45% is associated with a lower rate of thrombosis in polycythemia vera. In patients receiving hydroxyurea, this target can be achieved with hydroxyurea alone or with the combination of hydroxyurea plus phlebotomies. However, the clinical implications of phlebotomy requirement under hydroxyurea therapy are unknown. The aim of this study was to evaluate the need for additional phlebotomies during the first five years of hydroxyurea therapy in 533 patients with polycythemia vera. Patients requiring 3 or more phlebotomies per year (n=85, 16%) showed a worse hematocrit control than those requiring 2 or less phlebotomies per year (n=448, 84%). There were no significant differences between the two study groups regarding leukocyte and platelet counts. Patients requiring 3 or more phlebotomies per year received significantly higher doses of hydroxyurea than the remaining patients. A significant higher rate of thrombosis was found in patients treated with hydroxyurea plus 3 or more phlebotomies per year compared to hydroxyurea with 0–2 phlebotomies per year (20.5% vs. 5.3% at 3 years; P<0.0001). In multivariate analysis, independent risk factors for thrombosis were phlebotomy dependency (HR: 3.3, 95%CI: 1.5–6.9; P=0.002) and thrombosis at diagnosis (HR: 4.7, 95%CI: 2.3–9.8; P<0.0001). The proportion of patients fulfilling the European LeukemiaNet criteria of resistance/intolerance to hydroxyurea was significantly higher in the group requiring 3 or more phlebotomies per year (18.7% vs. 7.1%; P=0.001) mainly due to extrahematologic toxicity. In conclusion, phlebotomy requirement under hydroxyurea therapy identifies a subset of patients with increased proliferation of polycythemia vera and higher risk of thrombosis. PMID:27686377

Prevention of hepato-renal toxicity of radiation and cadmium by Aloe vera

International Nuclear Information System (INIS)

Chakrawarti, Aruna; Bhati, Sharvan Lal; Ojha, Shikha; Purkharam; Issran, Rakesh; Agarwal, Manisha; Purohit, R.K.

2014-01-01

Prevention, control and treatment of cancer remain challenge to the medical world. Development of effective and versatile drugs for cancer treatment is an integral part of the ongoing cancer research. The anti stress, hepato-protective, antioxidant and immune modulating properties of Aloe vera make it an ideal drug for developing anti-tumor drugs. Ionizing radiation has always been a part of the human environment. Along with natural radioactive sources present in the earth crust and cosmic radiation, special medical procedures (radiation therapy) also contribute to our continuous exposure to ionizing radiation. Radiation damage, is to a large extent, caused by the overproduction of reactive oxygen species (ROS), including superoxide anion (O 2 - ), hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ), that overwhelm the levels of antioxidants, resulting in oxidative stress and cellular damage. Efficient defense and repair mechanisms exist in living cells to protect against oxidant species. Humans are subjected to exposure of cadmium pollution through contaminated air, water, food, manufactured goods and occupational hazards. Cadmium stimulates free radical production, resulting in oxidative deterioration of lipids, proteins DNA and initiating various pathological conditions in human and animals once observed, Cadmium is rapidly cleared from the blood and concentrates in various tissues mainly in the liver and kidney causing many metabolic and histological changes. So it was of particular interest to investigate whether Aloe vera administration to mice would decrease the toxicity associated with oxidative stress and thereby reducing the damage induced by cadmium and gamma radiation exposure. For this purpose, six to eight weeks old mice were selected and divided into seven groups on the basis of radiation, cadmium, combined treatment and drug treated. All biochemical parameters of the control groups were compared with respective experimental groups. Value of total

Diagnosis and Management of Polycythemia Vera in a Ferret (Mustela putorius furo).

Science.gov (United States)

Le, Kim; Beaufrère, Hugues; Bassel, Laura L; Wills, Sarah; Laniesse, Delphine; Blois, Shauna L; Smith, Dale A

2016-12-01

A 5-y-old female ferret (Mustela putorius furo) was evaluated for diarrhea, anorexia, and lethargy for 1 wk. Only mild dehydration was detected on physical examination. CBC analysis revealed marked erythrocytosis with an unremarkable plasma biochemistry panel; follow-up CBC analyses revealed a consistent primary erythrocytosis. Whole-body radiographs and abdominal ultrasonography were unremarkable except for a small nephrolith in the right kidney and a small cyst in the left kidney. The plasma erythropoietin level was 17.0 mIU/mL and considered normal. In light of the diagnostic work-up and consistent erythrocytosis, a diagnosis of polycythemia vera (primary erythrocytosis) was made. The initial presentation of diarrhea resolved after treatment with oral metronidazole (20 mg/kg PO BID for 7 d). Treatment for the polycythemia consisted of a phlebotomy initially followed by chemotherapy with hydroxyurea (10 mg/kg PO BID). During the subsequent 12 mo, the hydroxyurea dose adjusted according to follow-up CBC results, and finding an optimal dosage regimen proved to be challenging. One year after the initial diagnosis, the ferret presented to an emergency clinic for acute and severe hemorrhagic diarrhea and died shortly thereafter. The postmortem diagnosis was acute venous infarction of the small and large intestine. To our knowledge, this report is the first to describe the diagnosis and long-term management of polycythemia vera in a ferret and the use of hydroxyurea for this purpose.

Physiopathology, etiologic factors, diagnosis, and course of polycythemia vera as related to therapy according to William Dameshek, 1940-1950

NARCIS (Netherlands)

J.J. Michiels (Jan)

2013-01-01

textabstractAccording to Dameshek, true polycythemia (polycythemia vera: PV) is a chronic myeloproliferative disorder of the total bone marrow without any evidence of invasiveness, in which erythrocytosis, leukocytosis, and thrombocytosis are all simultaneously present. A possible hereditary or

Validity of rapid estimation of erythrocyte volume in the diagnosis of polycytemia vera

Energy Technology Data Exchange (ETDEWEB)

Nielsen, S.; Roedbro, P.

1989-01-01

In the diagnosis of polycytemia vera, estimation of erythrocyte volume (EV) from plasma volume (PV) and venous hematocrit (Hct/sub v/) is usually thought unadvisable, because the ratio of whole body hematocrit to venous hematocrit (f ratio) is higher in patients with splenomegaly than in normal subjects, and varies considerably between individuals. We determined the mean f ratio in 232 consecutive patients suspected of polycytemia vera (anti f=0.967; SD 0.048) and used it with each patient's PV and Hct/sub v/ to calculate an estimated normalised EV/sub n/. With measured EV as a reference value, EV/sub n/ was investigated as a diagnostic test. By means of two cut off levels the EV/sub n/ values could be divided into EV/sub n/ elevated, EV/sub n/ not elevated (both with high predictive values), and an EV/sub n/ borderline group. The size of the borderline EV/sub n/ group ranged from 5% to 46% depending on position of the cut off levels, i.e. with the efficiency demanded from the diagnostic test. EV can safely and rapidly be estimated from PV and Hct/sub v/, if anti f is determined from the relevant population, and if the results in an easily definable borderline range of EV/sub n/ values are supplemented by direct EV determination.

Biocompatibility evaluation of Minalux and VeraBond2 in-vitro

Directory of Open Access Journals (Sweden)

Kandi Bidgoli M.

2005-05-01

Full Text Available Statement of Problem: One of newly presented base metal alloys (Minalux is produced according to VeraBond2 alloy (Ni- Cr base composition. Several studies showed that, cytotoxicity of base metal alloys can be occurred due to corrosion and element release. Purpose: This study evaluated the biocompatibility of these two base metal alloys in three steps: as cast, after polishing and after porcelain firing cycles. Release of Ni and Cr ions were measured to determine if there is any difference between these two alloys. Materials and Methods: Samples of two base metal alloys were subjected to Neutral Red Assay, MTT Assay and Trypan Blue for biocompatibility tests. Fibroblast Balb/c 3T3 cells were used for cell culture. Samples were contacted directly with cells in 37ºc and 5% Co2 concentration for 72 hours. Teflon samples were used as negative control. ANOVA test was used to compare different groups of two alloys. In addition, the release of Ni and Cr ions in to saline solution was measured by means of atomic absorption spectrometry. Results: MTT and Trypan Blue didn’t show any significant difference between Minalux, VeraBond2 and Teflon. Neutral Red Assay showed no significant difference between these two base metal alloys but as cast group was higher in cytotoxicity in comparisons with polished and firing groups in both two alloys. Release of Cr ion was non detectable (Cr < 1 PPB but Ni ion was measured and Ni release was significantly different in as cast groups (P=0.007 of two alloys. Conclusion: There is no significant difference between cytotoxicity of two base metal alloys and polishing and firing can decrease cytotoxicity of both alloys.

RES scintigraphy in polycythemia vera and secondary or relative polycythemia

Energy Technology Data Exchange (ETDEWEB)

Rudberg, U. (Depts. of Diagnostic Radiology and Internal Medicine, St. Goeran' s Hospital, Stockholm (Sweden)); Skaarberg, K.O. (Depts. of Diagnostic Radiology and Internal Medicine, St. Goeran' s Hospital, Stockholm (Sweden))

1993-03-01

Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in 11 of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCV, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size. (orig.).

RES scintigraphy in polycythemia vera and secondary or relative polycythemia

International Nuclear Information System (INIS)

Rudberg, U.; Skaarberg, K.O.

1993-01-01

Scintigraphy of the reticuloendothelial system (RES) was performed in 19 patients with polycythemia vera (PCV) and in 18 with secondary or relative polycythemia (PS). Bone marrow extension was found in all patients with PCV and in 11 of 18 patients with PS. The patients with PCV had a higher degree of extension than those with PS. Increased pelvic bone marrow activity was found in 16 of 19 PCV patients, but in none with PS. Splenomegaly was found in 9 patients with PCV, and in none with PS. It is concluded that RES scintigraphy in the majority of patients may differentiate between PCV and PS using the parameters pelvic bone marrow activity, bone marrow extension and splenic size. (orig.)

Karakterisasi Erwinia Chrysanthemi Penyebab Penyakit Busuk Bakteri Pada Daun Lidah Buaya (Aloe Vera)

OpenAIRE

SUPRIADI,; IBRAHIM, NILDAR; TARYONO,

2002-01-01

Characteristics o/Envinia chysanthemi causing bacterial soft rot ofAloe (Aloe VeraJThe bacterial sot rot of aloe, caused by Erwinia chrysanthemi, was first identified in Caibbean Island in 1992. In early 2001, similar symptoms were found on the aloe plants grown in Semplak, Bogor, West Java. Based on its symptom and progressively spread, especially on the leaf and basal stem, it appeared that the disease was serious and therefore threatened the current development of die plants. This study wa...

"I Was My War; My War Was I": Vera Brittain, Autobiography and University Fiction during the Great War

Science.gov (United States)

McClellan, Ann K.

2016-01-01

Applying the critical lenses of feminism, autographical theory and literary analysis, this essay performs a triple reading of Vera Brittain's multi-genre writings about gender, war,and university education. Focusing specifically on "The Dark Tide" (1923), "Testament of Youth" (1933) and "The Women of Oxford" (1960),…

Enriched adhesion of talc/ZnO nanocomposites on cotton fabric assisted by aloe-vera for bio-medical application

Energy Technology Data Exchange (ETDEWEB)

Selvakumar, D.; Yogamalar, N. R.; Jayavel, R., E-mail: rjvel@annauniv.edu [Centre for Nanoscience and Technology, Anna University, Chennai – 600025 (India); Thenammai, A. N.; Hemamalini, R. [Department of Physics, Queen Mary’s College, Chennai – 600004 (India)

2015-06-24

Synthesis and characterization of talc/ZnO nanocomposites with the assistance of aloe-vera are investigated by structural and morphological studies. The crystal structure and the phase analysis of ZnO and talc are characterized and confirmed by X-ray diffraction (XRD) analysis. The average crystallite size estimation from the Scherrer formula and the particle size analysis clearly predicts that the size of the ZnO declines when aloe-vera is used as a capping molecule in comparison to the commercially available ZnO. The reduced crystallite size of ZnO renders a stable cohesion with the talc composition and the presence of distinct functional group pyridines/ammonia in the synthesized nanocomposites enriches the good adhesion between the as-synthesized material and cotton fabric. The adhesion and homogeneous distribution of talc/ZnO nanocomposites on the cotton fabric are inferred from the scanning electron microscopy (SEM) results. The basic studies and characterizations would pave way for futuristic bio-medical application.

Enriched adhesion of talc/ZnO nanocomposites on cotton fabric assisted by aloe-vera for bio-medical application

International Nuclear Information System (INIS)

Selvakumar, D.; Yogamalar, N. R.; Jayavel, R.; Thenammai, A. N.; Hemamalini, R.

2015-01-01

Synthesis and characterization of talc/ZnO nanocomposites with the assistance of aloe-vera are investigated by structural and morphological studies. The crystal structure and the phase analysis of ZnO and talc are characterized and confirmed by X-ray diffraction (XRD) analysis. The average crystallite size estimation from the Scherrer formula and the particle size analysis clearly predicts that the size of the ZnO declines when aloe-vera is used as a capping molecule in comparison to the commercially available ZnO. The reduced crystallite size of ZnO renders a stable cohesion with the talc composition and the presence of distinct functional group pyridines/ammonia in the synthesized nanocomposites enriches the good adhesion between the as-synthesized material and cotton fabric. The adhesion and homogeneous distribution of talc/ZnO nanocomposites on the cotton fabric are inferred from the scanning electron microscopy (SEM) results. The basic studies and characterizations would pave way for futuristic bio-medical application

Enriched adhesion of talc/ZnO nanocomposites on cotton fabric assisted by aloe-vera for bio-medical application

Science.gov (United States)

Selvakumar, D.; Thenammai, A. N.; Yogamalar, N. R.; Hemamalini, R.; Jayavel, R.

2015-06-01

Synthesis and characterization of talc/ZnO nanocomposites with the assistance of aloe-vera are investigated by structural and morphological studies. The crystal structure and the phase analysis of ZnO and talc are characterized and confirmed by X-ray diffraction (XRD) analysis. The average crystallite size estimation from the Scherrer formula and the particle size analysis clearly predicts that the size of the ZnO declines when aloe-vera is used as a capping molecule in comparison to the commercially available ZnO. The reduced crystallite size of ZnO renders a stable cohesion with the talc composition and the presence of distinct functional group pyridines/ammonia in the synthesized nanocomposites enriches the good adhesion between the as-synthesized material and cotton fabric. The adhesion and homogeneous distribution of talc/ZnO nanocomposites on the cotton fabric are inferred from the scanning electron microscopy (SEM) results. The basic studies and characterizations would pave way for futuristic bio-medical application.

VERIFIKASI PAKET PROGRAM MVP-II DAN SRAC2006 PADA KASUS TERAS REAKTOR VERA BENCHMARK.

Directory of Open Access Journals (Sweden)

Jati Susilo

2015-03-01

Full Text Available Dalam penelitian ini dilakukan verifikasi perhitungan benchmark VERA pada kasus Zero Power Physical Test (ZPPT teras reaktor Watts Bar 1. Reaktor tersebut merupakan jenis PWR kelas 1000 MWe yang didesain oleh Westinghouse, tersusun dari 193 perangkat bahan bakar 17×17 dengan 3 jenis pengkayaan UO2 yaitu 2,1wt%, 2,619wt% dan 3,1wt%. Perhitungan nilai k-eff dan distribusi faktor daya dilakukan pada siklus operasi pertama teras dengan kondisi beginning of cycle (BOC dan hot zero power (HZP. Posisi batang kendali dibedakan menjadi uncontrolled (semua batang kendali berada di luar teras, dan controlled (batang kendali Bank D didalam teras. Paket program komputer yang digunakan dalam perhitungan adalah MVP-II dan SRAC2006 modul CITATION dengan data pustaka tampang lintang ENDF/B-VII.0. Hasil perhitungan menunjukkan bahwa perbedaan nilai k-eff teras pada kondisi controlled dan uncontrolled antara referensi dengan MVP-II (-0,07% dan -0,014% dan SRAC2006 (0,92% dan 0,99% sangat kecil atau masih dibawah 1%. Perbedaan faktor daya maksimum teras pada kondisi controlled dan uncontrolled dengan referensi dengan MVP-II adalah 0,38% dan 1,53%, sedangkan dengan SRAC2006 adalah 1,13% dan -2,45%. Dapat dikatakan bahwa kedua paket program komputer menunjukkan hasil perhitungan yang sesuai dengan nilai referensi. Dalam hal penentuan kekritisan teras, maka hasil perhitungan MVP-II lebih konservatif dibandingkan dengan SRAC2006. Kata kunci : MVP-II, SRAC2006, PWR, VERA   In this research, verification calculation for VERA core physics benchmark on the Zero Power Physical Test (ZPPT of the nuclear reactor Watts Bar 1. The reactor is a 1000 MWe class of PWR designed by Westinghouse, arranged from 193 unit of 17×17 fuel assembly consisting 3 type enrichment of UO2 that are 2.1wt%, 2.619wt% and 3.1wt%. Core power factor distribution and k-eff calculation has been done for the first cycle operation of the core at beginning of cycle (BOC and hot zero power (HZP. In this

Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats

International Nuclear Information System (INIS)

Holanda, Cecilia Maria de Carvalho Xavier; Medeiros, Aldo da Cunha

2009-01-01

Purpose: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na 99m TcO 4 and laboratorial parameters in Wistar rats. Methods: twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na 99m TcO 4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (% ATI/g) was determined. Biochemical dosages were performed. Results: there was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (p 99m TcO 4 in organs of rats and it was responsible to a high increase of levels of AST and ALT. (author)

Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat

DEFF Research Database (Denmark)

Andersen, Christen Lykkegaard; Bjørn, Mads Emil; McMullin, Mary Frances

2014-01-01

YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy...

Inventário arbóreo em dois bairros paulistanos, Jardim da Saúde e Vila Vera, localizados na subprefeitura de Ipiranga Arboreal inventory of two São Paulo city neighboorhoods (Jardim da Saude and Vila Vera located in Ipiranga district zone

Directory of Open Access Journals (Sweden)

Adriana Ines Napias Rossetti

2010-10-01

Full Text Available Foi realizado levantamento quantiqualitativo de vegetais de porte arbóreo em dois bairros paulistanos, Vila Vera e Jardim da Saúde, situados na região Sudeste de São Paulo, não distando muito entre si, porém com características de ocupação de uso do solo bastante distintas. No Jardim da Saúde, encontraram-se 1.033 exemplares de 72 espécies botânicas, cuja altura média de todas as árvores foi de 8,07 m. A Caesalpinea peltophoroides Benth. foi a espécie mais frequente, com 20,68%, seguida da Largestroemia indica L., com 7,48%. Predominavam árvores com mais de 8,50 m de altura, sendo o pior indicador de sanidade vegetal a infestação de cupins, com 8,33% do total. Apenas 23,33% tinham situações de permeabilidade do passeio suficiente, e 5,71% delas se encontravam com conduções de podas para desobstrução das redes aéreas; o rebaixamento das árvores aconteceu em 7,74% dos exemplares. Na Vila Vera havia 178 árvores pertencentes a 42 espécies botânicas, sendo a média da altura total de 6,31 m. A espécie mais abundante foi a Caesalpinea peltophoroides Benth., com 24,71%; a segunda seria a Ligustrum lucidum W.T. Aiton, com 17,24% do total. Em 42,70% das árvores, a altura foi inferior a 4,50 m, e a sanidade vegetal estava comprometida em 12,37% dos exemplares pela infestação de cupins. Somente 7,87% dos exemplares estavam em situações de permeabilidade suficiente, as conduções de poda para desobstrução de redes eram de 3,38% e as podas de rebaixamento, de 13,48%. Havia uma média de 16,85 m de afastamento entre árvores no Jardim da Saúde, enquanto na Vila Vera esse indicativo era de 38,68 m.An arboreal qualitative and quantitative study was conducted in two closely located neighborhoods (Vila Vera and Jardim da Saúde in the southeast region of São Paulo. In spite of geographical vicinity, both neighborhoods have very different land occupation characteristics. In Jardim da Saúde we found 1033 tree specimens

Erythrocytosis caused by giant chromophobe renal cell carcinoma: a case report indicating a 9-year misdiagnosis of polycythemia vera.

Science.gov (United States)

Guo, Renbo; Liang, Yiran; Yan, Lei; Xu, Zhonghua; Ren, Juchao

2017-09-06

Erythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma. We report a case of a young man suffering from a giant (22-cm) mass on his left kidney. Because of a history of polycythemia vera, the patient had been treated for the condition for 9 years. Radical nephrectomy was successfully performed, and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell carcinoma. Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. Further examination and analysis were performed, and we finally attributed his erythrocytosis to chromophobe renal cell carcinoma. Chromophobe renal cell carcinoma could cause erythrocytosis, but the clear-cut mechanism needs further research. Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.

Efeitos colaterais cutâneos após uso prolongado de hidroxiuréia na Policitemia Vera Cutaneous effects after prolongaded use of hydroxyurea in Polycythemia Vera

Directory of Open Access Journals (Sweden)

Emmanuel Rodrigues de França

2011-08-01

Full Text Available A hidroxiureia é um derivado hidroxilado da ureia utilizado em diversas desordens hematológicas. Inúmeras alterações cutâneas, porém raras, são relatadas após seu uso prolongado. A patogênese das mesmas não está bem esclarecida, porém, sugere-se que a droga tenha uma ação tóxica direta sobre a pele. Descrevemos um homem de 75 anos, branco, com diagnóstico de Policitemia Vera que, ao longo de 11 anos de tratamento com hidroxiureia, evoluiu com várias lesões cutâneas: hiperpigmentação da pele, lesões atróficas em antebraços, melanoníquia longitudinal das 20 unhas, úlcera em antebraço direito, xerose cutânea, ictiose em pernas e carcinoma espinocelular no pavilhão auricular direito. Até o momento, os relatos na literatura descrevem pouca diversidade de lesões nos pacientes acometidosHydroxyurea is an hydroxylated urea derivative used in many myeloproliferative disorders. Many, but unusual cutaneous disorders are related after its prolonged use. Their pathogenesis is not clear, but it is suggested that there is direct toxicity of the drug on the skin. We described a white, 75-year old man with diagnosis of Polycythemia Vera that in 11 years of treatment developed many cutaneous lesions: skin hyperpigmentation, atrophic lesions on forearms, longitudinal melanonychia of 20 nails, right forearm ulcer, cutaneous xerosis, ichthyosis and auricular spinocellular carcinoma. At this moment, the literature reports describe little diversity of lesions in affected patients

Astrometry of the Red Supergiant Star VY Canis Majoris with VERA

Science.gov (United States)

Choi, Y. K.; Hirota, T.; Honma, M.; Kobayashi, H.

2009-08-01

We present observational results on the red supergiant VY Canis Majoris with VERA. We have observed 22 GHz H_2O masers and 43 GHz SiO masers (v=1 and 2 J=1-0) around VY CMa for 13 months. We successfully detected a parallax of 0.87 ± 0.08 mas, corresponding to 1.15 +0.10 -0.09 kpc of distance using H_2O masers. As results of phase--referencing analyses, we have measured absolute positions for both the H_2O masers and SiO masers. The proper motions of the H_2O masers show the tendency of expansion.

In Vivo and in Vitro Micrografting of Pistachio, Pistacia vera L. cv. "Siirt"

OpenAIRE

ONAY, Ahmet; PİRİNÇ, Vedat; ADIYAMAN, Filiz; IŞIKALAN, Çiğdem; TİLKAT, Engin; BAŞARAN, Davut

2014-01-01

In this study, the success of in vivo and in vitro micrografts of pistachio (Pistacia vera L. cv. "Siirt") materials are presented. The only variable tested was age (1, 5, 10, and 30-year-old trees). Ten- to 12-day-old axenic seedlings germinated in vitro or seedlings (3 to 5 months-old) grown in pots in vivo were used as rootstocks. Shoot tips collected from the four age classes of mature trees of pistachio were the source of scions. Firm contact between the scion and roots...

Distance to VY Canis Majoris with VERA

Science.gov (United States)

Choi, Yoon Kyung; Hirota, Tomoya; Honma, Mareki; Kobayashi, Hideyuki; Bushimata, Takeshi; Imai, Hiroshi; Iwadate, Kenzaburo; Jike, Takaaki; Kameno, Seiji; Kameya, Osamu; Kamohara, Ryuichi; Kan-Ya, Yukitoshi; Kawaguchi, Noriyuki; Kijima, Masachika; Kim, Mi Kyoung; Kuji, Seisuke; Kurayama, Tomoharu; Manabe, Seiji; Maruyama, Kenta; Matsui, Makoto; Matsumoto, Naoko; Miyaji, Takeshi; Nagayama, Takumi; Nakagawa, Akiharu; Nakamura, Kayoko; Oh, Chung Sik; Omodaka, Toshihiro; Oyama, Tomoaki; Sakai, Satoshi; Sasao, Tetsuo; Sato, Katsuhisa; Sato, Mayumi; Shibata, Katsunori M.; Tamura, Yoshiaki; Tsushima, Miyuki; Yamashita, Kazuyoshi

2008-10-01

We report on astrometric observations of H2O masers around the red supergiant VY Canis Majoris carried out with VLBI Exploration of Radio Astrometry (VERA). Based on astrometric monitoring for 13 months, we successfully measured a trigonometric parallax of 0.88±0.08 mas, corresponding to a distance of 1.14+0.11-0.09kpc. This is the most accurate determined distance to VY CMa and the first one based on an annual parallax measurement. The luminosity of VY CMa has been overestimated due to a previously accepted distance. With our result, we re-estimated the luminosity of VY CMa to be (3±0.5) × 105Lodot using the bolometric flux integrated over optical and IR wavelengths. This improved luminosity value makes the location of VY CMa on the Hertzsprung-Russell (HR) diagram much closer to the theoretically allowable zone (i.e. the left side of the Hayashi track) than previous ones, though the uncertainty in the effective temperature of the stellar surface still does not permit us to make a final conclusion.

Ischaemic colitis and lung infiltrates caused by extramedullary haematopoiesis in a patient with an acute erythroid leukaemia following polycythaemia vera

NARCIS (Netherlands)

Brada, SJL; de Wolf, JTM; Poppema, S; Vellenga, E

A patient with 'spent' polycythaemia vera showed extensive extramedullary haematopoiesis (EMH) in non-haematopoietic tissue clinically resulting in an ischaemic colitis and respiratory symptoms due to lung infiltrates. On laboratory investigation, the EMH also included immature erythroblasts due to

Humoral responses of broiler chickens challenged with NDV following supplemental treatment with extracts of Aloe vera, Alma millsoni, Ganoderma lucidum and Archachatina marginata.

Science.gov (United States)

Ojiezeh, Tony I; Eghafona, Nosahkare'Odeh

2015-01-01

The significance of nutritional supplements for immunity has been documented. Locally sourced extracts used in alternative medicine were studied to determine their potential effects on antibody production and humoral responses in viral challenged birds. Three hundred and eighty birds were distributed into 19 groups of 20 birds each. Following acclimatization for 16 days, they were fed with standard broilers feed and water ad libitum. Group A was supplemented with Aloe vera (AV) extract, group B was given Alma millsoni (AM) extract, group C was given Archachatina marginata (AMS) extract and group D was given Ganoderma lucidum (GL) extract, and group E was the control group. Extract concentrations of 50 mg, 100 mg and 150 mg were given to three subsets of each treatment group for 30 days. Birds were then challenged with intramuscular administration of 0.2 ml of 50% Embryo Lethal Dose of saline suspension of the challenge strain of Newcastle Disease Virus (NDV) on the 30(th) day, and were examined for clinical signs and symptoms. Serum from venous blood was used for antibody and immunological assay. Aloe vera at 50 µg and A. millsoni extracts supplementations yielded a significant antibody titre (p vera enhanced the ability to mount humoral responses against viral infection in broiler chickens.

Comparative evaluation of antimicrobial effect of herbal root canal irrigants (Morinda citrifolia, Azadirachta indica, Aloe vera) with sodium hypochlorite: An in vitro study.

Science.gov (United States)

Babaji, Prashant; Jagtap, Kiran; Lau, Himani; Bansal, Nandita; Thajuraj, S; Sondhi, Priti

2016-01-01

Successful root canal treatment involves the complete elimination of microorganism from the root canal and the three-dimensional obturation of the canal space. Enterococcus faecalis is the most commonly found bacteria in failed root canal. Chemical irrigation of canals along with biomechanical preparation helps in the elimination of microorganisms. The present study was aimed to evaluate the antimicrobial effect of herbal root canal irrigants (Morinda citrifolia, Azadirachta indica extract, Aloe vera) with sodium hypochlorite (NaOCl). The bacterial E. faecalis (ATCC) culture was grown overnight in brain heart infusion (BHI) broth and inoculated in Mueller-Hinton agar plates. Antibacterial inhibition was assessed using agar well diffusion method. All five study irrigants were added to respective wells in agar plates and incubated at 37°C for 24 h. Bacterial inhibition zone around each well was recorded. Results were tabulated and statistically analyzed using Statistical Package for the Social Sciences software for Windows, version 19.0. (IBM Corp., Armonk, NY. Highest inhibitory zone against E. faecalis was seen in NaOCl fallowed by M. citrifolia and A. indica extract, and the least by A. vera extract. Tested herbal medicine (A. indica extract, M. citrifolia, A. vera) showed inhibitory zone against E. faecalis. Hence, these irrigants can be used as root canal irrigating solutions.

Aloe vera and Vitis vinifera improve wound healing in an in vivo rat burn wound model.

Science.gov (United States)

Lin, Li-Xin; Wang, Peng; Wang, Yu-Ting; Huang, Yong; Jiang, Lei; Wang, Xue-Ming

2016-02-01

Aloe vera and Vitis vinifera have been traditionally used as wound healing agents. The present study aimed to investigate the effects of aloe emodin and resveratrol in the burn wound healing procedure. Burn wounds are common in developed and developing countries, however, in developing countries, the incidence of severe complications is higher and financial resources are limited. The results of the present study demonstrated that neither aloe emodin or resveratrol were cytotoxic to THP-1 macrophages at concentrations of 1, 100 and 500 ng/ml. A significant increase in wound-healing activity was observed in mice treated with the aloe emodin and resveratrol, compared with those which received control treatments. The levels of IL-1β in the exudates of the burn wound area of the treated mice increased in a time-dependent manner over 7 days following burn wound injury. At 10 days post-injury, steady and progressive wound healing was observed in the control animals. The present study confirmed that increased wound healing occurs following treatment with aloe emodin,, compared with resveratrol, providing support for the use of Aloe vera plants to improve burn wound healing.

A Multidisciplinary Investigation of a Polycythemia Vera Cancer Cluster of Unknown Origin

Science.gov (United States)

Seaman, Vincent; Dearwent, Steve M; Gable, Debra; Lewis, Brian; Metcalf, Susan; Orloff, Ken; Tierney, Bruce; Zhu, Jane; Logue, James; Marchetto, David; Ostroff, Stephen; Hoffman, Ronald; Xu, Mingjiang; Carey, David; Erlich, Porat; Gerhard, Glenn; Roda, Paul; Iannuzzo, Joseph; Lewis, Robert; Mellow, John; Mulvihill, Linda; Myles, Zachary; Wu, Manxia; Frank, Arthur; Gross-Davis, Carol Ann; Klotz, Judith; Lynch, Adam; Weissfeld, Joel; Weinberg, Rona; Cole, Henry

2010-01-01

Cancer cluster investigations rarely receive significant public health resource allocations due to numerous inherent challenges and the limited success of past efforts. In 2008, a cluster of polycythemia vera, a rare blood cancer with unknown etiology, was identified in northeast Pennsylvania. A multidisciplinary group of federal and state agencies, academic institutions, and local healthcare providers subsequently developed a multifaceted research portfolio designed to better understand the cause of the cluster. This research agenda represents a unique and important opportunity to demonstrate that cancer cluster investigations can produce desirable public health and scientific outcomes when necessary resources are available. PMID:20617023

Policitemia vera: a propósito de um caso clínico

OpenAIRE

Joana Macedo; Emília Costa; José Barbot; Cláudia Neto

2015-01-01

A policitemia vera (PV) é um transtorno mieloproliferativo das células hematopoiéticas, caracterizada por uma produção anormal e acentuada de eritrócitos, leucócitos e plaquetas. Outras características da doença incluem esplenomegalia, complicações trombo-hemorrágicas, distúrbios vasomotores, prurido e um pequeno risco de progressão da doença para leucemia mielóide aguda ou mielofibrose. A trombose é o sintoma de apresentação em 20% dos pacientes com PV. É uma doença rara, com uma incidência ...

Haemostatic disturbances in Polycythemia vera and the influence of a radiophosphorus therapy

International Nuclear Information System (INIS)

Rasche, H.

1974-01-01

In approximately 50% of the cases of patients with polycythaemia vera (PV) who were not treated or who were treated inadequately, haemostatic disturbances are the direct cause of death. The pathomechanisms of this disturbance are shown briefly. A radiophosphorus treatment is applied preferably in older patients since a leucaemogenic effect cannot be excluded definitely. In this treatment 32 P is administered as individual dosage (5-10 mCi). In approximately 75% of the patients remission is achieved. The remission can last over several years. In 20-30% of the cases anaemia, leucocytopenia and thrombocytopenia appear as side effects. (MG) [de

Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose.

Science.gov (United States)

López Angulo, Daniel Enrique; do Amaral Sobral, Paulo José

2016-11-01

Biologically active scaffolds used in tissue engineering and regenerative medicine have been generating promising results in skin replacement. The present study aims to test the hypothesis that the incorporation of Aloe vera and snail mucus into scaffolds based on gelatin and chitosan could improve their structure, composition and biodegradability, with a potential effect on bioactivity. Homogeneous pore diameter as well as pore walls in the composite scaffold could be seen in the SEM image. The pores in the scaffolds were interconnected and their sizes ranged from 93 to 296μm. The addition of Aloe vera and snail mucus enlarged the mean pore size with increased porosity and caused changes in the pore architecture. The FTIR analysis has shown good affinity and interaction between the matrix and the Aloe, which may decrease water-binding sites, so this fact hindered the water absorption capacity of the material. The mechanical properties could explain the highest swelling capacity of the snail scaffold, because the high percentage of elongation could facilitate the entry of liquid in it, generating a matrix with plenty of fluid retention. The real innovation in the present work could be the use of these substances (Aloe and snail mucus) for tissue engineering. Copyright © 2016 Elsevier B.V. All rights reserved.

Phosphorus-32 in polycythemia vera with and without maintenance treatment. Intermediate follow-up results

International Nuclear Information System (INIS)

Najean, Y.; Rain, J.D.

1995-01-01

Three-hundred and seventy-two patients with polycythemia vera, aged 65 years or more or with a high risk of vascular complications, were openly treated between 1979 and 1994 with 32 P or a combination of 32 P plus a small maintenance dose (7,5 mg/kg/day) of hydroxy urea. Although only a small number of patients was followed long enough to allow definite conclusions, some results are already significant in this intermediary study performed in November 1994. Maintenance treatment with hydroxy urea led to a significant prolongation of the intervals between 32 P administrations and to a decreased annual mean dose of radiophosphorus. Median survival does not differ between to the two treatment groups, 10,7 years compared to 10,0 years. The rate of vascular complications did not differ between groups. At 10 years follow-up, the risk of developing (epithelial) cancer was increased in the group of patients who received maintenance treatment, 30% compared to 10%. Similarly, development of myelodysplasia, acute leukemia or lymphoma was more common in patients receiving hydroxy urea, 25% compared to 12%. Myeloid transformation of the spleen occurred with the same frequency. Our intermediate follow-up results show that addition of hydroxy urea to 32 P treatment does not change survival or vascular complications in polycythemia vera patients, but probably increases the risk of developing cancer or leukemia. (authors). 2 refs., 4 figs

Psicoanalisi ed educazione: il lavoro di Vera Schmidt e di Sabina Spielrein nell’asilo sperimentale di Mosca (1921-1925

Directory of Open Access Journals (Sweden)

Merete Amann Gainotti

2012-12-01

Full Text Available Negli anni 1921-1923 a Mosca, sulla scia delle profonde trasformazioni politiche e sociali innescate dalla Rivoluzione di ottobre si colloca un esperimento educativo originale, promosso da Vera Schmidt, una pedagogista formata alle idee psicoanalitiche, che si proponeva di cercare nuove vie educative per la prima infanzia sulla base delle recenti conquiste e conoscenze fornite dalla teoria psicoanalitica di S. Freud. Obiettivo di questo contributo è di fornire un breve excursus storico relativo alla diffusione della psicoanalisi in Unione sovietica e alla fondazione dell'asilo sperimentale di Mosca, di ricordare le figure delle due studiose Vera Schmidt e Sabina Spielrein che hanno animato l'iniziativa, il cui lavoro scientifico è rimasto in ombra rispetto a quello dei loro più famosi colleghi S. Freud e di C.G. Jung; infine si intende rendere conto dei principi educativi che esse cercarono di mettere in pratica nell'asilo sperimentale di Mosca.

Aspirin in polycythemia vera and essential thrombocythemia: current facts and perspectives.

Science.gov (United States)

Landolfi, R; Patrono, C

1996-09-01

The role of aspirin in the antithrombotic strategy of patients with polycythemia vera (PV) and essential thrombocythemia (ET) is highly controversial. Long considered unsafe on the basis of a single clinical trial testing very high doses in PV patients, aspirin is being increasingly used at lower dosage. The rationale for the use of aspirin in patients with PV and ET is provided by the efficacy of this agent in the treatment of microcirculatory disturbances of thrombocythemic states associated with myeloproliferative disorders and by recent evidence that asymptomatic PV and ET patients have persistently increased thromboxane (TX) A2-biosynthesis. This increase, which most likely reflects enhanced platelet activation in vivo, is independent of the platelet mass and blood viscosity and largely supressed by a short term low-dose aspirin regimen (50 mg/day for 7 days). Since enhanced TXA2 biosynthesis may play a role in transducing the increased thrombotic risk associated with PV and ET, long-term low-dose aspirin administration has been proposed as a possible antithombotic strategy in these subjects. The safety of this treatment in PV patients has been recently reassessed by the Gruppo Italiano per lo Studio della Policitemia Vera (GISP) which has followed for over one year 112 patients randomized to receive 40 mg/day aspirin or placebo. In the same study, serum TXB2 measurements provided evidence that the low-dose aspirin regimen tested was fully effective in inhibiting platelet cyclooxygenase activity. On this basis, a large scale trial aimed at assessing the antithrombotic efficacy of this approach is currently being organized. In patients with ET both the minimal aspirin dose required for complete inhibition of platelet cyclooxygenase and the safety of long-term aspirin administration need to be established prior to extensive clinical evaluation of this strategy.

Genome survey of pistachio (Pistacia vera L.) by next generation sequencing: Development of novel SSR markers and genetic diversity in Pistacia species.

Science.gov (United States)

Ziya Motalebipour, Elmira; Kafkas, Salih; Khodaeiaminjan, Mortaza; Çoban, Nergiz; Gözel, Hatice

2016-12-07

Pistachio (Pistacia vera L.) is one of the most important nut crops in the world. There are about 11 wild species in the genus Pistacia, and they have importance as rootstock seed sources for cultivated P. vera and forest trees. Published information on the pistachio genome is limited. Therefore, a genome survey is necessary to obtain knowledge on the genome structure of pistachio by next generation sequencing. Simple sequence repeat (SSR) markers are useful tools for germplasm characterization, genetic diversity analysis, and genetic linkage mapping, and may help to elucidate genetic relationships among pistachio cultivars and species. To explore the genome structure of pistachio, a genome survey was performed using the Illumina platform at approximately 40× coverage depth in the P. vera cv. Siirt. The K-mer analysis indicated that pistachio has a genome that is about 600 Mb in size and is highly heterozygous. The assembly of 26.77 Gb Illumina data produced 27,069 scaffolds at N50 = 3.4 kb with a total of 513.5 Mb. A total of 59,280 SSR motifs were detected with a frequency of 8.67 kb. A total of 206 SSRs were used to characterize 24 P. vera cultivars and 20 wild Pistacia genotypes (four genotypes from each five wild Pistacia species) belonging to P. atlantica, P. integerrima, P. chinenesis, P. terebinthus, and P. lentiscus genotypes. Overall 135 SSR loci amplified in all 44 cultivars and genotypes, 41 were polymorphic in six Pistacia species. The novel SSR loci developed from cultivated pistachio were highly transferable to wild Pistacia species. The results from a genome survey of pistachio suggest that the genome size of pistachio is about 600 Mb with a high heterozygosity rate. This information will help to design whole genome sequencing strategies for pistachio. The newly developed novel polymorphic SSRs in this study may help germplasm characterization, genetic diversity, and genetic linkage mapping studies in the genus Pistacia.

Coexistence of gain-of-function JAK2 germ line mutations with JAK2(V617F) in polycythemia vera

Czech Academy of Sciences Publication Activity Database

Láníková, Lucie; Babošová, Oľga; Swierczek, S.; Wang, L.; Wheeler, D.A.; Divoky, V.; Kořínek, Vladimír; Prchal, J.T.

2016-01-01

Roč. 128, č. 18 (2016), s. 2266-2270 ISSN 0006-4971 R&D Projects: GA ČR GJ15-18046Y; GA MŠk LO1419 Institutional support: RVO:68378050 Keywords : JAK2 mutations * polycythemia vera Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 13.164, year: 2016

Small Bowel Obstruction Caused by Aloe vera Bezoars: A Case Report.

Science.gov (United States)

Hong, In Taik; Cha, Jae Myung; Ki, Hye Jin; Kwak, Min Seob; Yoon, Jin Young; Shin, Hyun Phil; Jeoun, Jung Won; Choi, Sung Il

2017-05-25

Small bowel obstruction is a clinical condition commonly caused by postoperative adhesion, volvulus, intussusceptions, and hernia. Small bowel obstruction due to bezoars is clinically uncommon, accounting for approximately 2-4% of all obstructions. Computed tomography (CT) is a useful method in diagnosing the cause of small bowel obstruction. However, small bowel obstruction caused by bezoars may not be detected by an abdominal CT examination. Herein, we report a rare case of small bowel obstruction by Aloe vera bezoars, which were undetected by an abdominal CT. Phytobezoars should be included in the differential diagnosis of small bowel obstruction in patients with predisposing factors, such as excessive consumption of high-fiber food and diabetes.

Aloe vera extract reduces 8-oxo-2'-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats

Directory of Open Access Journals (Sweden)

Wulan Christijanti

2017-04-01

Full Text Available Background Diabetes mellitus is a chronic disease caused by lack of insulin production in the pancreas or by insulin resistance, the disease being characterized by elevated blood glucose levels. Hyperglycemia in diabetes could lead to oxidative stress due to the rise in 8-oxo-2'-deoxyguanosine (8-oxo-dG levels and the decrease in levels of total antioxidant status (TAS. The purpose of this study was to assess the effect Aloe vera extract on 8-oxo-dG level and total antioxidant status in diabetic rat testis.   Methods This was an experimental laboratory study with 20 rat samples which were divided into 4 groups (1 control group and 3 treatment groups. Diabetes was induced in the rats by streptozotocin (STZ at 65 mg/kgBW. The diabetic rats were then treated for 28 days with Aloe vera extract at 0 mg (P0, 200 mg rind (P1, 200 mg pulp (P2, respectively. The level of 8 -oxo-dG was measured by ELISA and total antioxidant status with 2,2' -azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS. Data were analyzed with ANOVA and Least Significant Difference Advanced Test at P<0.05.   Results 8-Oxo-dG levels were significantly different between the control group and both P0 and P2, but not between the control group and P1. Among the treatment groups the 8-oxo-dG levels were significantly different. Mean total antioxidant status was significantly different between control and treatment groups, and also between treatment groups (p<0.05.   Conclusions Aloe vera extract reduced free radicals (level of 8-oxo-dG and increased the total antioxidant status in diabetic rat testis.

Polycythemia vera: diagnosis, different therapy modalities and clinical value of the treatment with radiophosphorus today; Polycythaemia vera: Diagnostik, Differenzialtherapie und Stellenwert der {sup 32}P-Behandlung heute

Energy Technology Data Exchange (ETDEWEB)

Bredow, J.; Pinkert, J.; Franke, W.G. [Klinik und Poliklinik fuer Nuklearmedizin TU Dresden (Germany); Schuler, U. [Medizinische Klinik und Poliklinik I, Universitaetsklinikum ' ' Carl Gustav Carus' ' an der TU Dresden (Germany)

2001-07-01

The definition, diagnostic criteria and clinical findings as well as the treatment with radioactive phosphorus is described more in detail. Today, the treatment with {sup 32}P is estimated to be an easy and safe method, especially for elderly patients (65 years or above), providing a cost-effective alternative to anti-proliferative drugs like hydroxyurea. (orig.) [German] Es wird auf das Krankheitsbild per se, die Diagnostikkriterien und klinischen Befunde eingegangen und die Radiophosphortherapie bei Patienten mit PCV beschrieben. Aus heutiger Sicht steht mit der Radiophosphortherapie der Polycythaemia vera ein einfaches und sicheres Verfahren zur Verfuegung, welches insbesondere bei aelteren (ueber 65-jaehrigen) Patienten eine praktikable und kostenguenstige Alternative zur medikamentoesen antiproliferativen Therapie mit Hydroxyharnstoff darstellt. (orig.)

Selection of variants with high levels of biotin from cultured green Lavandula vera cells irradiated with gamma rays

International Nuclear Information System (INIS)

Watanabe, K.; Yamada, Y.

1982-01-01

Cultured green Lavandula vera cells were irradiated with various dosages of gamma rays which increased the variation in the amount of free biotin produced by the cell clones. Variant sublines containing much more free biotin than the original line were obtained by repeated selection. The effectiveness of gamma rays for the induction of the variant sublines is described

Examination of an aloe vera galacturonate polysaccharide capable of in situ gelation for the controlled release of protein therapeutics

Science.gov (United States)

McConaughy, Shawn David

A therapeutic delivery platform has been investigated with the ultimate goal of designing a sustained protein release matrix utilizing an in-situ gelling, acidic polysaccharide derived from the Aloe vera plant. The Aloe vera polysaccharide (AvP) has been examined in order to determine how chemical composition, structure, molecular weight and solution behavior affect gelation and protein/peptide delivery. Correlations are drawn between structural characteristics and solution behavior in order to determine the impact of polymer conformation and solvation on gel formation under conditions designed to simulate nasal applications. Steady state and dynamic rheology, classic and dynamic light scattering, zeta potential, pulse field gradient nuclear magnetic resonance and fluorescence spectroscopy have been employed to gain insight into the effects of galacturonic acid content, degree of methylation, entanglement and ionic strength on both solution behavior and the hydrogel state which ultimately governs protein/peptide release. This dissertation is divided into two sections. In the first section, a series of Aloe vera polysaccharides (AvP), from the pectin family have been structurally characterized indicating high galacturonic acid (GalA) content, low degree of methylester substitution (DM), low numbers of rhamnose residues and high molecular weight with respect to pectins extracted from traditional sources. The behavior of AvP was examined utilizing dilute solution, low-shear rheological techniques for specific molecular weight samples at selected conditions of ionic strength. From these dilute aqueous solution studies, the Mark-Houwink-Sakurada (MHS) constants (K and alpha), persistence length (Lp) and inherent chain stiffness (B parameter) were determined, indicating an expanded random coil in aqueous salt solutions. The critical concentration for transition from dilute to concentrated solution, C e, was determined by measuring both the zero shear viscosity and

Efectividad de la crema de Aloe vera en pacientes con psoriasis vulgar de la Parroquia San Fernando

Directory of Open Access Journals (Sweden)

Yoisel Belen Ruiz

2014-10-01

Full Text Available Se realizó un estudio de intervención terapéutica en 20 pacientes con psoriasis vulgar, pertenecientes a la Parroquia San Fernando, en Montes, Estado Sucre (Venezuela, de mayo a diciembre del 2013, quienes fueron seleccionados aleatoriamente y asignados en 2 grupos de idéntica cantidad de integrantes: el de control, que utilizó medicación convencional con triamcinolona, y el de estudio, que recibió tratamiento tópico con crema de Aloe vera (sábila de base inerte; a fin de determinar la efectividad de esta última. Para establecer la comparación entre ambos grupos, se emplearon técnicas no paramétricas debido al número reducido de pacientes, y siempre se consideró un nivel de significación de 0,05. Se obtuvo que la modalidad terapéutica con crema de sábila fuera tan efectiva como la aplicación de la triamcinolona, pero a diferencia de esta última, no presentó reacciones adversas. Así, pudo concluirse que la terapia con Aloe vera es efectiva para tratar pacientes con psoriasis vulgar

Supercritical Carbon Dioxide extraction of Aloe Emodin and Barbaloin from Aloe Vera L. leaves and their in-vitro cytotoxic activity

International Nuclear Information System (INIS)

Kabbash, A.; El-Soud, K.A.; Zalat, E.; Shoeib, N.; Yagi, A.

2008-01-01

Aloe emodin and barbaloin, isolated as the active principles of the medicinal plant Aloe vera L., were extracted by supercritical fluid extraction (SFE) and analyzed by high performance liquid chromatography (HPLC). With optimized operating conditions for SFE, aloe emodin and barbaloin were quantitatively extracted from A. Vera leaves within 20 minutes at a flow rate of 0.3 ml/min, temperature and pressure at 40C and 3200 Psi respectively with the addition of 1 ml of methanol as a modifier. Separation of aloe emodin and barbaloin, in a pure form, from the SFE extract was achieved using a semi-preparative column. The cytotoxic activity of both aloe emodin and barbaloin were evaluated using the in-vitro MTT colorimetric assay. Aloe emodin showed a cytotoxic activity on two human colon cancer cells lines (DLD-1 and HD-29) with IC 8.94 and 10.78 M respectively, while barbaloin had no effect. (author)

Development of Pistachio (Pistacia vera L.) spread.

Science.gov (United States)

Shakerardekani, Ahmad; Karim, Roselina; Ghazali, Hasanah Mohd; Chin, Nyuk Ling

2013-03-01

Pistachio nut (Pistacia vera L.) is one of the most delicious and nutritious nuts in the world. Pistachio spreads were developed using pistachio paste as the main component, icing sugar, soy protein isolate (SPI), and red palm oil (RPO), at different ratios. The highest mean scores of all the sensory attributes were depicted by spreads that were made without addition of SPI. It was found that the work of shear was 0 to 11.0 kg s for an acceptable spread. Sensory spreadability, overall texture, spreadability, and overall acceptability were negatively correlated (R > 0.83) with the work of shear of spreads. The findings indicated that the presence of RPO had a direct effect on the viscoelastic behavior of the pistachio spreads. The a values, which are related to the green color of the pistachio product ranged from 1.7 to 3.9 for spread without addition of RPO, and 4.0 to 5.3 in the presence of RPO. The development of pistachio spread would potentially increase the food uses of pistachio and introduce consumers with a healthier snack food. © 2013 Institute of Food Technologists®

Violencia Escolar y Rendimiento Académico (VERA: aplicación de realidad aumentada

Directory of Open Access Journals (Sweden)

Mª del Carmen Pérez-Fuentes

2011-08-01

Full Text Available En la actualidad, dos son los problemas que de forma más notable comprometen el clima escolar en los Centros de Educación Secundaria: la violencia entre alumnos y el bajo rendimiento académico. Ambos aspectos, son tratados en múltiples trabajos de investigación, de donde se extraen datos que apoyan la existencia de una relación, cuanto menos compleja, entre la violencia escolar y el rendimiento académico. De la necesidad de crear nuevas herramientas para evaluar la convivencia escolar y su relación con el rendimiento académico; surge el desarrollo del recurso que presentamos: VERA-Nivel I. Se trata de un videojuego de realidad aumentada, que nos permite recabar información detallada sobre las formas de interacción que tienen los alumnos y con quién, y también, acerca de las habilidades cognitivas que poseen. Además, una de las ventajas que ofrece el uso de realidad aumentada es la posibilidad de analizar las interacciones de los alumnos con sus propios compañeros, en el contexto real del aula. De forma paralela, la aplicación nos permite recompensar conductas no violentas. La aplicación VERA-Nivel I no solo se limita al ámbito educativo, sino que puede y debe ser generalizada a otros contextos en los que proceda el mismo objeto de evaluación.

Rectification of radiation-induced damage in swiss albino mice by aloe vera leaf extracts (AVE)

International Nuclear Information System (INIS)

Gehlot, P.; Goyal, P. K.

2007-01-01

From the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. Radiation protection concepts and philosophy have been evolving over the past several decades. Materials and Methods: The radioprotective of effect of Aloe vera leaf extract (1000 mg/kg b.wt. orally for 15 consecutive days) has been studied against 6 Gy of gamma radiation in the intestine of Swiss albino mice at various post irradiation intervals viz. 12 hours, 24 hours. and 3, 5, 10, 20 and 30 days. Results: Crypt survival, villus length, apoptic cells, mitotic figures and goblet cells in jejunum were studied after irradiation. Irradiation produced a significant decrease in crypt survival, mitotic figures and villus length; whereas goblet and apoptic cells showed a significant increase from sham irradiated animals. The major changes were observed on day 3 after irradiation. AVE pre-treated irradiated animals resulted in a significant increase in the number of crypt cells, mitotic figures and villus length; whereas the counts of apoptic and goblet cells showed a significant decrease from respective control group at all the autopsy intervals. Irradiated animals resulted in the elevation in lipid peroxidation and a reduction in glutathione activity. On contrary, AVE treatment before irradiation caused a significant depletion in lipid peroxidation and elevation in glutathione activity. Conclusion: The present study suggests the possible radioprotective ability of Aloe vera leaf extract

Tolerance of Mycorrhiza infected pistachio (Pistacia vera L.) seedling to drought stress under glasshouse conditions.

Science.gov (United States)

Abbaspour, H; Saeidi-Sar, S; Afshari, H; Abdel-Wahhab, M A

2012-05-01

The influence of Glomus etunicatum colonization on plant growth and drought tolerance of 3-month-old Pistacia vera seedlings in potted culture was studied in two different water treatments. The arbuscular mycorrhiza (AM) inoculation and plant growth (including plant shoot and root weight, leaf area, and total chlorophyll) were higher for well-watered than for water-stressed plants. The growth of AM-treated seedlings was higher than non-AM-treatment regardless of water status. P, K, Zn and Cu contents in AM-treated shoots were greater than those in non-AM shoots under well-watered conditions and drought stress. N and Ca content were higher under drought stress, while AM symbiosis did not affect the Mg content. The contents of soluble sugars, proteins, flavonoid and proline were higher in mycorrhizal than non-mycorrhizal-treated plants under the whole water regime. AM colonization increased the activities of peroxidase enzyme in treatments, but did not affect the catalase activity in shoots and roots under well-watered conditions and drought stress. We conclude that AM colonization improved the drought tolerance of P. vera seedlings by increasing the accumulation of osmotic adjustment compounds, nutritional and antioxidant enzyme activity. It appears that AM formation enhanced the drought tolerance of pistachio plants, which increased host biomass and plant growth. Copyright © 2012 Elsevier GmbH. All rights reserved.

Anti-Melanogenic Activity and Cytotoxicity of Pistacia vera Hull on Human Melanoma SKMEL-3 Cells.

Science.gov (United States)

Sarkhail, Parisa; Salimi, Mona; Sarkheil, Pantea; Mostafapour Kandelous, Hirsa

2017-07-01

Pistacia vera seed is a common food and medicinal seed in Iran. It's hull (outer skin) as a significant byproduct of pistachio, is traditionally used as tonic, sedative and antidiarrheal and has been shown to be a rich source of antioxidants. The aim of the present study is to evaluate the anti-melanogenic activity of the pistachio hulls in order to discover a new alternative herbal agent to treat skin hyperpigmentation disorders. In this work, antioxidant and anti-tyrosinase activity of MeOH extract from Pistacia vera hull (MPH) were evaluated in vitro, respectively, by DPPH radical scavenging and mushroom tyrosinase activity assays. Then the effect of MPH on the melanin content, cellular tyrosinase activity and cytotoxicity (MTT assay) on human melanoma SKMEL-3 cell were determined followed by 72 h incubation. The results indicated that MPH had valuable DPPH radical scavenging effect and weak anti-tyrosinase activity when compared to the well-known antioxidant (BHT) and tyrosinase inhibitor (kojic acid), respectively. MPH, at a high dose (0.5 mg/mL), showed significant cytotoxic activity (~63%) and strong anti-melanogenic effect (~57%) on SKMEL-3 cells. The effect of MPH in the reduction of melanin content may be related to its cytotoxicity. The results obtained suggest that MPH can be used as an effective agent in the treatment of some skin hyperpigmentation disorders such as melanoma.

Efficacy of passive ultrasonic irrigation with natural irrigants (Morinda citrifolia juice, Aloe Vera and Propolis) in comparison with 1% sodium hypochlorite for removal of E. faecalis biofilm: an in vitro study.

Science.gov (United States)

Bhardwaj, Anuj; Velmurugan, Natanasabapathy; Ballal, Suma

2013-01-01

Present study evaluated the efficacy of natural derivative irrigants, Morinda citrifolia juice (MCJ), Aloe Vera and Propolis in comparison to 1% sodium hypochlorite with passive ultrasonic irrigation for removal of the intraradicular E. faecalis biofilms in extracted single rooted human permanent teeth. Biofilms of E. faecalis were grown on the prepared root canal walls of 60 standardized root halves which were longitudinally sectioned. These root halves were re-approximated and the samples were divided into five groups of twelve each. The groups were, Group A (1% NaOCl), Group B (MCJ), Group C (Aloe vera), Group D (Propolis) and Group E (Saline). These groups were treated with passive ultrasonic irrigation (PUI) along with the respective irrigants. The root halves were processed for scanning electron microscopy. Three images (X2.5), coronal, middle and apical, were taken for the twelve root halves in each of the five groups. The images were randomized and biofilm coverage assessed independently by three calibrated examiners, using a four-point scoring system. 1% NaOCl with passive ultrasonic irrigation (PUI) was effective in completely removing E. faecalis biofilm and was superior to the natural irrigants like MCJ, Aloe vera and Propolis tested in this study. 1% NaOCl used along with passive ultrasonic irrigation was effective in completely removing E. faecalis biofilm when compared to natural irrigants (MCJ, Aloe Vera and Propolis).

Kui Arno isaga ... / Kati Saara Vamann

Index Scriptorium Estoniae

Vatmann, Kati Saara, 1967-

2016-01-01

Portreelood ühise eesnimega tegusatest meestest, pankrotihaldur Arno Mägist, meelelahutajatest ja muusikutest Arno Kukest ning Arno Suislepast, spordimehest Arnold Tokkost ja pedagoogist, Sillamäe gümnaasiumi direktorist Arno Kaseniidust

Avaliação da atividade mutagênica e antimutagênica da Aloe vera em teste de Allium cepa e teste de micronúcleo em linfócitos humanos binucleados

Directory of Open Access Journals (Sweden)

Régis T. Sturbelle

Full Text Available Algumas das substâncias presentes nos vegetais podem ter efeitos mutagênicos, enquanto outras podem atenuar ou anular estes efeitos. Estima-se que mais de 200 substâncias ativas façam parte do gel de Aloe vera, sendo que os polissacarídeos chegam a 30%, e muitos dos benefícios terapêuticos, nutricionais e cosméticos são a eles atribuídos. O objetivo deste trabalho foi determinar o efeito mutagênico e antimutagênico da solução de Aloe vera, em teste de Allium cepa e teste de micronúcleos em linfócitos humanos binucleados. Para as soluções, as folhas de Aloe vera foram trituradas, filtradas e esterilizadas. O teste de Allium cepa foi constituído de oito tratamentos e o de linfócitos, de cinco (com quatro repetições. Observou-se que na dose usual, a solução de Aloe vera não foi mutagência para o sistema de teste vegetal e nem para o humano. Já na dose dez vezes mais concentrada provocou um efeito citotóxico e mutagênico em Allium cepa. Em células vegetais a solução foi antimutagênica apenas quando colocada depois do paracetamol, enquanto que nas células humanas, essa ação se manifestou quando a solução foi utilizada ao mesmo tempo com o paracetamol.

RECOMBINANT HUMAN MAST-CELL GROWTH-FACTOR SUPPORTS ERYTHROID COLONY FORMATION IN POLYCYTHEMIA-VERA IN THE PRESENCE AND ABSENCE OF ERYTHROPOIETIN AND SERUM

NARCIS (Netherlands)

MULLER, EW; DEWOLF, JTM; HENDRIKS, DW; ESSELINK, MT; HALIE, MR; VELLENGA, E

The effect of mast cell growth factor (MGF) was studied on erythropoietin (Epo)-dependent and Epo-independent (''spontaneous'') erythroid colony formation in patients with polycythemia vera (PV). MGF stimulated both Epo-dependent and Epo-independent erythroid colony formation from PV peripheral

A Clinical Study on Polycythemia Vera

Energy Technology Data Exchange (ETDEWEB)

Lee, Gwon Jun; Hong, Kee Suk; Cho, Kyung Sam; Kim, Byoung Kook; Kim, Noe Kyeong; Koh, Chang Soon; Lee, Mun Ho [Seoul National University College of Medicine, Seoul (Korea, Republic of)

1977-03-15

Eight patients with polycythemia vera were diagnosed from 1965 through 1977 among the patients of Seoul National University Hospital. In our series there were 4 men and 4 women with average age of 54 years at the time of diagnosis. Symptoms of facial plethora, headache, pruritus and dizziness were the most frequent manifestations of disease in order of frequency. At initial examination 8 of 8 patients had facial plethora, 6 of 8 patients splenomegaly and 4 if 8 patients hepatomegaly. The laboratory data revealed mean Red cell volume of 55+10 ml/kg which was elevated in all cases. Leukocytosis was observed in 5 of 8 patients and thrombocytosis 2 of 8 patients. Leukocyte alkaline phosphatase was increased in all cases. Bone marrow aspiration disclosed typical panmyelosis in 5 of 8 patients. In one patient there was diffuse myelofibrosis on bone marrow biopsy. The combined diseases included 2 patient with hypertension and 1 patient with thrombosis of aorta and left renal artery. The patients were treated with phlebotoany alone in 2 patients, chemotherapy with busulfan in 1 patient and {sup 32}P in 5 patients with favorable results. During the mean 29.9 months follow up period, there were development of iron deficiency in 3 patients, hyperuricemia in 2 patients and thrombosis in 1 patient. The occurrence of acute leukemia of myelofibrosis was not observed in the course of disease.

A Clinical Study on Polycythemia Vera

International Nuclear Information System (INIS)

Lee, Gwon Jun; Hong, Kee Suk; Cho, Kyung Sam; Kim, Byoung Kook; Kim, Noe Kyeong; Koh, Chang Soon; Lee, Mun Ho

1977-01-01

Eight patients with polycythemia vera were diagnosed from 1965 through 1977 among the patients of Seoul National University Hospital. In our series there were 4 men and 4 women with average age of 54 years at the time of diagnosis. Symptoms of facial plethora, headache, pruritus and dizziness were the most frequent manifestations of disease in order of frequency. At initial examination 8 of 8 patients had facial plethora, 6 of 8 patients splenomegaly and 4 if 8 patients hepatomegaly. The laboratory data revealed mean Red cell volume of 55+10 ml/kg which was elevated in all cases. Leukocytosis was observed in 5 of 8 patients and thrombocytosis 2 of 8 patients. Leukocyte alkaline phosphatase was increased in all cases. Bone marrow aspiration disclosed typical panmyelosis in 5 of 8 patients. In one patient there was diffuse myelofibrosis on bone marrow biopsy. The combined diseases included 2 patient with hypertension and 1 patient with thrombosis of aorta and left renal artery. The patients were treated with phlebotoany alone in 2 patients, chemotherapy with busulfan in 1 patient and 32 P in 5 patients with favorable results. During the mean 29.9 months follow up period, there were development of iron deficiency in 3 patients, hyperuricemia in 2 patients and thrombosis in 1 patient. The occurrence of acute leukemia of myelofibrosis was not observed in the course of disease.

A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients

International Nuclear Information System (INIS)

Merchant, Thomas E; Bosley, Christina; Smith, Julie; Baratti, Pam; Pritchard, David; Davis, Tina; Li, Chenghong; Xiong, Xiaoping

2007-01-01

Radiation dermatitis is a common side effect of radiation therapy (RT). In severe cases, RT must be interrupted until the skin heals, which can compromise treatment. The purpose of the study was to compare an anionic polar phospholipid (APP)-based cream and an aloe vera-based gel to determine their effectiveness in preventing and treating radiation dermatitis. Forty-five pediatric patients (median age, 11 years) with various diagnoses who received at least 23.4 Gy participated. APP cream and aloe vera gel were symmetrically applied within the irradiated field after each treatment. Three measures were collected before, during and after completion of treatment: subject's skin comfort, dermatologic assessment, and common toxicity criteria (CTC). Significant differences in specific variables favoring APP cream use were noted in some patients including skin comfort variables, dry (p = 0.002), soft (p = 0.057), feels good (p = 0.002), rough (p = 0.065), smooth (p = 0.012) and dermatologic variables, dryness (p = 0.013), erythema (p = 0.002) and peely (p = 0.008). Grouped CTC scores were supportive of APP cream (p = 0.004). In comparing the first and last assessments, two dermatologic variables, dryness (p = 0.035) and peely (p = 0.016), favored APP cream. APP cream is more effective than aloe vera-based gel for prevention and treatment of radiation dermatitis

El secreto de Vera Drake (2004) y Las Normas de la Casa de la Sidra (1999): el aborto en el cine y su utilización en la docencia

OpenAIRE

Icart Isern, M. Teresa (Maria Teresa); Rozas García, M. Rosa; Icart Isern, M. Carmen

2007-01-01

El Secreto de Vera Drake (2004) de Mike Leigh y de Las Normas de la Casa de la Sidra (1999) de Lasse Hallström presentan la interrupción voluntaria del embarazo y las circunstancias que la rodean en un total de diez abortos y un parto. El Secreto de Vera Drake nos muestra a una mujer de clase media-baja que"ayuda a chicas jóvenes" a poner fin a embarazos no deseados sin aceptar dinero a cambio. Su secreto se desvelará cuando una de las jóvenes a la que practicó un aborto sufre complicaciones ...

Preliminary Studies on Antimicrobial Activity of Extracts from Aloe Vera Leaf, Citrus Hystrix Leaf, Zingiber Officinale and Sabah Snake Grass Against Bacillus Subtilis

Directory of Open Access Journals (Sweden)

Uda M.N.A.

2018-01-01

Full Text Available Herbal plants have several potential antimicrobial activities either as antifungal or antibacterial to fight against the disease and pathogen that attack the plants. The extractions of the Aloe vera leaf, Citrus hystrix leaf, Zingiber officinale rhizome and Sabah snake grass were selected in this study to fight against Bacillus subtilis. B. subtilis is a Gram-positive bacterium, rodshaped and catalase-positive that lives on decayed organic material. It is known as Gram-positive bacteria because of its thick peptidoglycan and would appear purple when subjected to Gram test. This species is commonly found in the upper layers of the soil, in meat or vegetables, in pastry, cooked meat, in bread or poultry products. The extracts of Sabah Snake Grass found to be most effective than A.vera leaf, Z. officinale, and C. hystrix against the B. subtilis.

AMS-measurements of stable platinum isotopes in presolar nanodiamonds with the help of a negative-ion-injector for VERA

International Nuclear Information System (INIS)

Melber, K.

2011-01-01

The Vienna Environmental Research Accelerator (VERA) is a universal facility for Accelerator Mass Spectrometry (AMS). VERA is based on a 3-MV tandemaccelerator and enables one to investigate isotope ratios down to 10 -16 over the whole mass range of the elements. The main application is the measurement of long-lived radioisotopes of cosmogenic or anthropogenic origin (e.g. 10 Be, 14 C, 26 Al, 36 Cl, 41 Ca, 129 I, 236 U, 244 Pu). In principle it is also possible to detect stable isotopes of trace elements (Trace Element AMS: TEAMS). TEAMS is of particular interest with regard to so-called presolar grains in meteorites. Presolar grains contain trace elements whose isotope compositions differ substantially from those of our solar system. This points to a presolar origin of these grains. Among presolar grains, nanodiamonds are still poorly understood. They are composed of only a few thousand carbon atoms and contain platinum as one of the trace elements. There are still questions on their origin. E.g. were they 'doped' with the trace elements in the environment of a supernova? Which nucleosynthetic processes have taken place? Here the isotope signatures could deliver additional information. The aim of the present work was to establish conditions at VERA for the measurement of stable platinum isotopes in presolar nanodiamonds. The difficulty of such a measurement lies in the fact that trace analyses of stable Pt isotopes are only possible if the platinum background of the ion source is low. Hence, a new negative ion injector with a new sputtersource in which platinum was never used as a test material was build up at VERA. It was then possible to carry out Pt-isotope measurements in nanodiamonds for the first time. The sample material originates from the Allende-meteorite and was purified for nanodiamonds by the cosmochemistry group of the Max Planck Institute of Chemistry in Mainz. As a main result of the measurements it was possible to detect an access of the heaviest

AMS of 36Cl with the VERA 3 MV tandem accelerator

International Nuclear Information System (INIS)

Martschini, Martin; Andersson, Pontus; Forstner, Oliver; Golser, Robin; Hanstorp, Dag; Lindahl, Anton O.; Kutschera, Walter; Pavetich, Stefan; Priller, Alfred; Rohlén, Johan; Steier, Peter; Suter, Martin; Wallner, Anton

2013-01-01

Recent progress with compact ionization chambers has opened new possibilities for isobar suppression in accelerator mass spectrometry (AMS). Separation of 36 Cl (t 1/2 = 0.30 Ma) at natural isotopic levels from its stable isobar 36 S became feasible at particle energies of 24 MeV, which are also accessible for medium-sized tandem accelerators with 3 MV terminal voltage like VERA (Vienna Environmental Research Accelerator). Investigations with an ionization chamber revealed how physics favors isobar separation even at energies below the maximum of the Bragg curve. The strong energy focusing effect at high energy losses reduces energy straggling significantly and isobar separation steadily increases up to almost full energy loss. With an optimized detection setup, sulfur suppression factors of 2 × 10 4 have been achieved. Refraining from the additional use of degrader foils has the benefit of high transmission to the detector (∼16%), but requires a low sulfur output from the ion source. Therefore several backing materials have been screened for sulfur content. The dependence of the sulfur output on the AgCl sample size has been investigated as well. Precision and accuracy have been thoroughly assessed over the last two years. Since drifts in the spectra are efficiently corrected by monitoring the position of the 36 S peak, the reproducibility for high ratio samples ( 36 Cl/Cl > 10 −12 ) is better than 2%. Our blank value of 36 Cl/Cl ≈ (5 ± 5) × 10 −16 is competitive to other labs. 36 Cl has become a routine AMS-isotope at VERA. Recently we also explored novel techniques for additional sulfur suppression already in the ion source. While results with a small gas reaction cell in front of the sputter target were discouraging, a decrease in the sulfur/chlorine ratio by one order of magnitude was achieved by directing 300 mW continuous wave laser beam at 445 nm towards the cathode in the ion source.

Shape- and Size-Controlled Synthesis of Silver Nanoparticles Using Aloe vera Plant Extract and Their Antimicrobial Activity

Science.gov (United States)

Logaranjan, Kaliyaperumal; Raiza, Anasdass Jaculin; Gopinath, Subash C. B.; Chen, Yeng; Pandian, Kannaiyan

2016-11-01

Biogenic synthesis of silver nanoparticles (AgNP) was performed at room temperature using Aloe vera plant extract in the presence of ammoniacal silver nitrate as a metal salt precursor. The formation of AgNP was monitored by UV-visible spectroscopy at different time intervals. The shape and size of the synthesized particle were visualized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. These results were confirmed by X-ray powder diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses and further supported by surface-enhanced Raman spectroscopy/Raman scattering (SERS) study. UV-visible spectrum has shown a sharp peak at 420 nm and further evidenced by FTIR peak profile (at 1587.6, 1386.4, and 1076 cm-1 with corresponding compounds). The main band position with SERS was noticed at 1594 cm-1 (C-C stretching vibration). When samples were heated under microwave radiation, AgNP with octahedron shapes with 5-50 nm were found and this method can be one of the easier ways to synthesis anisotropic AgNP, in which the plant extract plays a vital role to regulate the size and shape of the nanoparticles. Enhanced antibacterial effects (two- to fourfold) were observed in the case of Aloe vera plant protected AgNP than the routinely synthesized antibiotic drugs.

Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats.

Science.gov (United States)

Ehsani, Vahid; Amirteimoury, Morteza; Taghipour, Zahra; Shamsizadeh, Ali; Bazmandegan, Gholamreza; Rahnama, Amir; Khajehasani, Fatemeh; Fatemi, Iman

2017-11-01

Pistacia vera is a plant of the family Anacardiaceae found in Central and West Asia. P. vera nut (Pistachio) possess multiple pharmacological effects such as antimicrobial, anti-hyperlipidemia, antioxidant and anti-inflammatory. This study is designed to evaluate the protective effect of the hydroalcoholic extract of pistachio on gentamicin-induced nephrotoxicity in rats. Nephrotoxicity was induced in rats by intraperitoneal injection of gentamicin (100 mg/kg/day for 7 days). Hydroalcoholic extract of pistachio (10, 50 and 100 mg/kg/p.o) was administered for 7 days. The nephroprotective activity was evaluated by determining creatinine clearance, serum creatinine, urine volume, urine glucose and blood urea nitrogen (BUN) levels. The kidneys were processed for histopathological examinations and all specimens were examined for morphologic parameters involving tubular degeneration, tubular necrosis and tubule interstitial nephritis. Results showed a significant increase in the levels of serum creatinine, urine volume, urine glucose and BUN and decrease of creatinine clearance by gentamicin (GA) administration. Co-administration with pistachio extract showed reduction in the levels of serum creatinine, urine volume, urine glucose and BUN and increase of creatinine clearance in all doses but the most significant alteration was observed in doses of 100 mg/kg. Also, the nephroprotective effect of the GA was confirmed by the histological examination of the kidneys. The study revealed the nephroprotective effect of the hydroalcoholic extract of pistachio. These findings suggest that pistachio treatment may attenuate renal dysfunction and structural damage through the reduction of oxidative stress and inflammation in the kidney.

Influence of Polysaccharides from Aloe vera (Aloe barbadensis Miller, Liliaceae on Mechanically Induced Cough in Cats

Directory of Open Access Journals (Sweden)

Martina Šutovská

2010-01-01

Full Text Available Different plants have been reported to be a source of polysaccharides that possess a great variety of biological activities, including cough suppression. The experiments were aimed on the influence of two polysaccharides isolated from the gel (A, HF1-Z and one from the epidermis (SL-1 of Aloe vera leaves, characterized by chemical composition and structural properties, on the cough reflex. The method of mechanically induced cough was used in conscious cats. A nylon fibre directed individually into the mucous area of the laryngopharyngeal and tracheobronchial airways via endotracheal cannula elicited the cough reflex. Statistical evaluation registered cough reflex indicators (number of cough efforts - NE, cough frequency - NE min–1 intensity of cough attacks during expiration and inspiration - IA+ and IA-, intensity of maximal inspiratory and expiratory cough efforts - IME- and IME+ showed that gel polysaccharide HF1-Z possessed higher cough-suppressing activity than dropropizine, a nonnarcotic peripheral cough suppressant. Their antitussive activity was accompanied mainly with a decrease of NE, IA+ and IA- from both laryngopharyngeal and tracheobronchial mucous areas of the airways. Results of the presented study also showed minimal influence of polysaccharide HF1-Z on expectoration predictor, IME- and IME+. New pharmacodynamic property of polysaccharides isolated from Aloe vera was shown during experiments, which could be a base of their possible therapeutic use in this indication in future.

Mälupuutuja puudutus / Reet Varblane

Index Scriptorium Estoniae

Varblane, Reet, 1952-

1998-01-01

Ando Keskküla kuraatornäitus "Puutujad" Tallinna Kunstihoones, näituse lähtekohtadest. Moskvalaste AESi rühmituse (Tatjana Arzamazova, Lev Jevzotovitch, Jevgeni Svjatski), hiina kunstniku Zhang¡Dali, Teemu Mäki, vene kunstniku Juri Alberti, Izabella Gustowska, Saara Ekströmi, Mart Viljuse töödest, poola kunstniku Maciej Toporowiczi videost "Kinnisidee".

Vozes da Poesia Contemporânea: A Dicção de Vera Lúcia de Oliveira e a Poesia do Interdito

Directory of Open Access Journals (Sweden)

Eduardo Dall’Alba

2013-06-01

Full Text Available This text proposes a reading on the thematic of Vera Lúcia de Oliveira poems that deal with death, pain, laceration and loss condensed into precise verses where no word remains. Hidden pain and dumb screams go through her work and raise her poetry to a tragic dimension

INTERTEXTUALITY IN THE DEATH OF A PILOT: THE KUBERNETES ARISTOS IN LUCIAN’S VERAE HISTORIAE.

Directory of Open Access Journals (Sweden)

Nicholas D. Newman

2015-12-01

Full Text Available In Lucian’s Verae Historiae, Lucian ensures the success of his voyage by providing the very best supplies and equipment for his men. As part of his preparation he hires on the best pilot that money could buy, this pilot is only heard from at one other point in the narrative, at his death in the belly of the sea monster. This paper examines the intertextual context of the pilot’s death and how Lucian uses it to further the juxtaposition of himself with that greatest of liars, Odysseus.

EVALUATION OF FREEZE DRIED ALOE VERA AND NOPAL CACTUS FOR POSSIBLE HEALTH TREATMENTS BY COMPARISON OF ANTIOXIDANT PROPERTIES AND FREE RADICAL INHIBITION.

Science.gov (United States)

Rodriguez, Kenneth R; Jones, Anthony E; Belmont, Barbara

2014-01-01

The goal of this project was to characterize the antioxidant powers of lyophilized Aloe Vera ( Aloe barbadensis ) and Nopal Cactus (Opuntia ficus-indica) by quantifying the phenolics content and radical scavenging abilities of preparations derived from these plants. Extracts of these lyophylized succulents were assayed for phenolic compounds by the Folin Ciocalteau method and compared for free radical scavenging capability by the DPPH method. We found that even though the Aloe lyophilizate extract contained more phenolic content, the Nopal lyophilizate exhibited better free radical scavenging ability. Aloe Vera extract contained 0.278 g/L of phenolic content and exhibited 11.1% free radical inhibition, with a free radical scavenging rate constant of 0.177±0.015 min -1 . Nopal Cactus extract contained 0.174 g/L of phenolic content and exhibited 13.2% free radical inhibition, with a free radical scavenging rate constant of 0.155±0.009 min -1 . These results showed Nopal to have greater antioxidant potency than Aloe.

Determination of the Presence of crpgenes in Staphylococcus aureus, Staphylococcus epidermidis, Lactobacillus delbrueckii and Corynebacterium veraSuş

OpenAIRE

BELDÜZ, Ali Osman; DEMİRBAĞ, Zihni; DÜLGER, Sabriye

2014-01-01

Polymerase chain reaction (PCR) was employed to detect the presence of cyclic AMP receptor protein (CPR) in a number of diverse organisms. In PCR, two primers specific to the crp gene of Escherichia coli were used. Staphylococcus aureus, Staphylococcus epidermidis, Lactobacillus delbrueckii and Corynebacterium veraSuş all showed the same size of PCR frağments (708 bp) and same restriction frağment length polymorphizm (RFLP).

Late Miocene extension partitioning in the eastern Betics: from W- to E-directed extension between the Sorbas and Vera basins (SE Spain).

Science.gov (United States)

Giaconia, Flavio; Booth-Rea, Guillermo; Martínez-Martínez, Jose Miguel; Azañon, Jose Miguel

2014-05-01

Late Miocene westward-directed extension in the Betics produced elongated core-complexes like Sierra Nevada and the Sierra de Filabres, tilted-block domains and associated basins. This extension represents the superficial manifestation of the rupture of the Tethyan slab and associated edge delamination along a lithospheric transform fault beneath the northern branch of the Gibraltar Arc orogenic system. However, crustal thinning at the eastern Betics occurs progressively towards the east suggesting an eastward-directed extension, probably related to the late Miocene opening of the Algero-Balearic basin. In order to define the kinematics and timing of such a heterogeneous extension at the eastern Betics we have carefully mapped a key area at the transition between the Sorbas and Vera basins. Field data indicate that extension in the area started at the southern margin of the Vera basin during the Serravallian (13.8 Ma) and continued until the Tortonian (approximately 8 Ma). This extension was characterized by a set of NE- to E-directed normal faults to the east, in the Vera basin, and a set of SW-directed normal faults to the west, towards the Sorbas basin. This opposite-directed extension is segmented by E-W to WNW-ESE strike-slip faults like the North Cabrera dextral transfer fault that accommodates NE- to E-directed extension to the north and SW-directed extension to the south. This structure resulted in westward tilted blocks that lead to Serravallian-Tortonian depocenters deepening towards the east at the Vera basin along the northern side of Sierra Cabrera. Meanwhile, at the western termination of Sierra Cabrera, westward-directed extension migrated SW-ward forming the Sorbas basin during the Tortonian (approximately 9-7.24 Ma). This extension was characterized by a listric fan of SW-directed normal faults highly segmented by E-W to NE-SW transfer. This extensional system produced tiled-blocks defining a Tortonian depocenter at the eastern margin of the Sorbas

Processed Aloe vera Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity

Directory of Open Access Journals (Sweden)

Sun-A Im

2014-10-01

Full Text Available The effects of processed Aloe vera gel (PAG on cyclophosphamide (CP-induced immunotoxicity were examined in mice. Intraperitoneal injection of CP significantly reduced the total number of lymphocytes and erythrocytes in the blood. Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in a dose-dependent manner. The reversal of CP-induced hematotoxicity by PAG was mediated by the functional preservation of Peyer’s patch cells. Peyer’s patch cells isolated from CP-treated mice, which were administered PAG, produced higher levels of T helper 1 cytokines and colony-stimulating factors (CSF in response to concanavalin A stimulation as compared with those isolated from CP-treated control mice. PAG-derived polysaccharides directly activated Peyer’s patch cells isolated from normal mice to produce cytokines including interleukin (IL-6, IL-12, interferon-γ, granulocyte-CSF, and granulocyte-macrophage-CSF. The cytokines produced by polysaccharide-stimulated Peyer’s patch cells had potent proliferation-inducing activity on mouse bone marrow cells. In addition, oral administration of PAG restored IgA secretion in the intestine after CP treatment. These results indicated that PAG could be an effective immunomodulator and that it could prevent CP-induced immunotoxic side effects.

Effects of nanoencapsulated aloe vera, dill and nettle root extract as feed antibiotic substitutes in broiler chickens

OpenAIRE

A. Meimandipour; A. Nouri Emamzadeh; A. Soleimani

2017-01-01

Aloe vera, nettle and dill are herbs that have been used in the poultry diet as feed additives to utilise their benefits in improving performance, immune response and health of broiler chickens. However, reactive and volatile properties of bioactive compounds in herbal extracts cause limitations on direct usage of them in the diet. The use of chitosan (CS) nanoparticles for the entrapment of active components has gained interest in the last few years due to its mucous adhesi...

El sustrato neolítico en la cuenca de Vera (Almería

Directory of Open Access Journals (Sweden)

Fernández-Miranda, Manuel

1993-12-01

Full Text Available The economic and social evolution in the southeastern region of the Iberian Peninsula during the Chalcolithic and the Bronze Age has been a focus for analysis by researchers ever since Siret conducted his studies of the area towards the end of the nineteenth century. In his work, he proposed diffusionist hypotheses linked to the appearance of metallurgy in the area, but in his conclusions, he failed, among other considerations, to include the existence of a Neolithic cultural substratum. The identification in the village of Cuartillas, together with other findings in the Valley of Vera (Almería, of a Neolithic community related to that of other areas in eastern Andalucía, brings new light to bear on the hypotheses considered to date.

Los análisis sobre la evolución económica y social en el sudeste de la Península Ibérica durante el Calco lítico y la Edad del Bronce han llamado la atención de los investigadores desde los trabajos llevados a cabo por Siret en la región a partir de los últimos años del siglo XIX. Su explicación presentaba algunos problemas, entre otros la indefinición de un sustrato cultural neolítico, lo que condujo a proponer hipótesis de carácter difusionista vinculadas a la aparición de la metalurgia en la zona. La identificación en la aldea de Cuartillas y otros yacimientos de la Cuenca de Vera (Almería de una población neolítica emparentable con la de otras áreas de Andalucía oriental, permite replantear desde nuevas perspectivas los supuestos hasta ahora considerados.

Monitoring of pistachio (Pistacia Vera) ripening by high field nuclear magnetic resonance spectroscopy.

Science.gov (United States)

Sciubba, Fabio; Avanzato, Damiano; Vaccaro, Angela; Capuani, Giorgio; Spagnoli, Mariangela; Di Cocco, Maria Enrica; Tzareva, Irina Nikolova; Delfini, Maurizio

2017-04-01

The metabolic profiling of pistachio (Pistacia vera) aqueous extracts from two different cultivars, namely 'Bianca' and 'Gloria', was monitored over the months from May to September employing high field NMR spectroscopy. A large number of water-soluble metabolites were assigned by means of 1D and 2D NMR experiments. The change in the metabolic profiles monitored over time allowed the pistachio development to be investigated. Specific temporal trends of amino acids, sugars, organic acids and other metabolites were observed and analysed by multivariate Partial Least Squares (PLS) analysis. Statistical analysis showed that while in the period from May to September there were few differences between the two cultivars, the ripening rate was different.

Molecular Profiling of Peripheral Blood Cells from Patients with Polycythemia Vera and Related Neoplasms: Identification of Deregulated Genes of Significance for Inflammation and Immune Surveillance

DEFF Research Database (Denmark)

Skov, Vibe; Larsen, Thomas Stauffer; Thomassen, Mads

2012-01-01

Essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are haematopoietic stem cell neoplasms that may be associated with autoimmune or chronic inflammatory disorders. Earlier gene expression profiling studies have demonstrated aberrant expression of genes involved...

Darwin, Hume, Morgan, and the verae causae of psychology.

Science.gov (United States)

Clatterbuck, Hayley

2016-12-01

Charles Darwin and C. Lloyd Morgan forward two influential principles of cognitive ethological inference that yield conflicting results about the extent of continuity in the cognitive traits of humans and other animals. While these principles have been interpreted as reflecting commitments to different senses of parsimony, in fact, both principles result from the same vera causa inferential strategy, according to which "We ought to admit no more causes of natural things, than such as are both true and sufficient to explain their appearances". Instead, the conflict stems from Darwin's and Morgan's views about the true causes of human psychology. Darwin holds a thoroughly Humean philosophy of the human mind, from which he infers significant continuity between human and animal minds. In contrast, Morgan argues that Humean cognitive mechanisms cannot account for a class of uniquely human behaviors, and therefore, he concludes that there is a significant discontinuity between human and animal cognition. This historical debate is informative for current controversies in comparative psychology. Copyright © 2016 Elsevier Ltd. All rights reserved.

As Representações Fílmicas de Vera Silvia Magalhães: Gênero, Testemunho e Resistência

Directory of Open Access Journals (Sweden)

Cesar Alessandro Sagrillo Figueiredo

2018-02-01

Full Text Available The period of armed struggle in Brazil lasted from 1968 to 1975, with the purpose of combating the military dictatorship and aiming for a return to democracy in the country. After the end of the armed period, later, there was a profusion of memorialistic books of the literature genre of the testimony, as a political balance of the characters who wielded weapons. Also, as a reflection of this literary production there was a great film production that portrayed this moment in Brazilian history. This article has as main objective to examine the film representation of the guerrilla leader Vera Silvia Magalhães in the two films that she was portrayed, respectively in the films What is that companion (1997 and Memoria that tell me (2013. Vera Silvia became a paradigmatic figure being considered in the period of the armed struggle the muse of the left and galvanizing its image until the present time. Therefore, this article works beyond literature and cinema, too, with the framing of memory and history through the biographical study of this character. For methodological purposes, it will be a qualitative work, since it aims at the historical reconstitution of a period through a biographical study, and especially the content analysis of the cinematographic production of the films made.

Assessment of Feeding Acceptance and Injury of Kerman Pistachios, Pistacia vera, by Brown Marmorated Stink Bug (Hemiptera: Pentatomidae)

OpenAIRE

Lara, Jesús R; Kamiyama, Matthew T; Hernandez, Gabriel; Nay, Justin; Hoddle, Mark S

2017-01-01

Abstract In the United States, California (CA) is the primary commercial producer of pistachio nuts, Pistacia vera L. (Anacardiaceae). The brown marmorated stink bug (BMSB), Halyomorpha halys (Stål) (Hemiptera: Pentatomidae), an invasive and polyphagous insect pest from Asia, has established in urban areas in several pistachio-growing counties in CA. Breeding BMSB populations have not been detected in commercial pistachio acreage. However, the detection of BMSB in Kern and Fresno counties, ma...

SiO MASERS AROUND WX PSC MAPPED WITH THE KVN AND VERA ARRAY (KaVA)

Energy Technology Data Exchange (ETDEWEB)

Yun, Youngjoo; Cho, Se-Hyung; Kim, Jaeheon; Choi, Yoon Kyung; Kim, Dong-Jin; Yoon, Dong-Hwan; Byun, Do-Young; Chung, Hyunsoo; Chung, Moon-Hee; Han, Myoung-Hee [Korea Astronomy and Space Science Institute, 776 Daedeok-daero, Yuseong, Daejeon 305-348 (Korea, Republic of); Imai, Hiroshi; Oyadomari, Miyako [Graduate School of Science and Engineering, Kagoshima University, 1-21-35 Korimoto, Kagoshima 890-0065 (Japan); Asaki, Yoshiharu [National Astronomical Observatory of Japan (NAOJ) Chile Observatory/Joint ALMA Observatory (JAO), Alonso de Cordova 3107, Vitacura 763 0355, Santiago (Chile); Chibueze, James O. [Department of Physics and Astronomy, Faculty of Physical Sciences, University of Nigeria, Carver Building, 1 University Road, Nsukka (Nigeria); Dodson, Richard; Rioja, María J. [International Centre for Radio Astronomy Research, M468, The University of Western Australia, 35 Stirling Hwy, Crawley, Western Australia 6009 (Australia); Kusuno, Kozue [Department of Space and Astronautical Science, School of Physical Sciences, The Graduate University for Advanced Studies (SOKENDAI), 3-1-1 Yoshinodai, Chuou-Ku, Sagamihara, Kanagawa 252-5210 (Japan); Matsumoto, Naoko; Hagiwara, Yoshiaki [Mizusawa VLBI Observatory, National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Min, Cheulhong, E-mail: yjyun@kasi.re.kr, E-mail: cho@kasi.re.kr [Department of Astronomical Sciences, The Graduate University for Advanced Studies (SOKENDAI), 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); and others

2016-05-01

We present the first images of the v = 1 and v = 2 J = 1 → 0 SiO maser lines taken with KaVA, i.e., the combined array of the Korean Very Long Baseline Interferometry (VLBI) Network and the VLBI Exploration of Radio Astrometry (VERA), toward the OH/IR star WX Psc. The combination of long and short antenna baselines enabled us to detect a large number of maser spots, which exhibit a typical ring-like structure in both the v = 1 and v = 2 J = 1 → 0 SiO masers as those that have been found in previous VLBI observational results of WX Psc. The relative alignment of the v = 1 and v = 2 SiO maser spots are precisely derived from astrometric analysis, due to the absolute coordinates of the reference maser spot that were well determined in an independent astrometric observation with VERA. The superposition of the v = 1 and v = 2 maser spot maps shows a good spatial correlation between the v = 1 and v = 2 SiO maser features. Nevertheless, it is also shown that the v = 2 SiO maser spot is distributed in an inner region compared to the v = 1 SiO maser by about 0.5 mas on average. These results provide good support for the recent theoretical studies of the SiO maser pumping, in which both the collisional and the radiative pumping predict the strong spatial correlation and the small spatial discrepancy between the v = 1 and v = 2 SiO maser.

"El secreto de Vera Drake" y nuestro secreto: aborto e hipocresía social

OpenAIRE

García Manrique, Ricardo

2006-01-01

La historia de Vera Drake nos recuerda no sólo los tiempos pasados sino también los nuestros, porque, como entonces, las mujeres todavía no controlan su cuerpo; pueden abortar, pero tienen que mentir sobre el por qué; pueden abortar, pero eso no forma parte de su derecho a la salud y a la sanidad básicas. Detrás de ello lo que asoma es una cierta construcción ideológica del aborto que aún mantiene parte de la fuerza que tuvo antaño, y que, por eso, la bioética debe seguir revisando y cuest...

Policitemia Vera. Experiencias en el diagnóstico y tratamiento en el Instituto de Hematología e Inmunología: Experiences in diagnosis and treatment in the Institute of Hematology and Immunology Polycythemia vera

Directory of Open Access Journals (Sweden)

Norma Fernández-Delgado

2011-03-01

Full Text Available La policitemia Vera se encuentra entre las neoplasias mieloides según la clasificación más reciente de la Organización Mundial de la Salud (OMS. Sus criterios diagnósticos han tenido variaciones en los últimos años y en este trabajo se realiza un análisis de estos criterios, así como de la respuesta a los tratamientos empleados en 349 pacientes atendidos en el Instituto de Hematología e Inmunología en los últimos 40 años. Se sugiere, dada su factibilidad y eficacia, continuar utilizando por el momento la clasificación OMS del 2001, y de acuerdo con la experiencia acumulada, se propone el tratamiento con medicamentos de primera y segunda líneas según la edad y las características clínicas de cada enfermo.The Polycythemia vera is located among the myeloid neoplasms according to the more recent classification of the HWO. Its diagnostic criteria have underwent variations in past years and in present paper authors made an analysis of such criteria, as well as of the response to treatments applied in 349 patients seen in the Institute of Hematology and Immunology during the past 40 years. Due to feasibility and effectiveness, for the moment, is has been suggested to carry on with the use of the classification of WHO of 2001, and according to the experience gained, it is proposed the treatment with first and second line drugs by age and the clinical features of each patient.

Sustained major molecular response on interferon alpha-2b in two patients with polycythemia vera

DEFF Research Database (Denmark)

Larsen, Thomas Stauffer; Bjerrum, O W; Pallisgaard, N

2008-01-01

Quantitative assessment of the JAK2 V617F allele burden during disease evolution and ongoing myelosuppressive treatment is likely to be implemented in the future clinical setting. Interferon alpha has demonstrated efficacy in treatment of both chronic myeloid leukemia and the Philadelphia chromos...... with a JAK2 V617F allele burden below 1.0% in two patients with polycythemia vera treated with interferon alpha-2b (IFN-2b). Discontinuation of IFN-2b in one of the patients was followed by a sustained long-lasting (12 months of follow-up) major molecular response....

Pilot plant experience on high-level waste solidification and design of the engineering prototype VERA

Energy Technology Data Exchange (ETDEWEB)

Guber, W; Diefenbacher, W; Hild, W; Krause, H; Schneider, E; Schubert, G

1972-11-01

In the present paper the solidification process for highly active waste solutions as developed in the Karlsruhe Nuclear Research Center is presented. Its principal steps are: denitration, calcination in a spray calciner operated with superheated steam, melting of the calcine with appropriate additives to borosilicate glass in an induction-heated melting furnace. The operational experiences gained so far in the inactive 1:1 pilot plant are reported. Furthermore, a description is given of the projected multi-purpose experimental facility VERA 2 which is provided for processing the highly active waste solutions from the first German reprocessing plant WAK.

Anormalidades Cromosómicas en la Microsporogénesis de Aloe Vera (L.) Burm. F. (Aloaceae)

OpenAIRE

IMERY BUIZA, José; CEQUEA RUÍZ, Hernán

2002-01-01

El objetivo del presente trabajo es verificar la existencia de anormalidades cromosómicas asociadas a la baja fertilidad del polen en Aloe vera. El estudio se realizó a partir del aplastamiento de anteras inmaduras fijadas en etanol-acético y coloreadas con orceína. La viabilidad del polen se determinó en microcultivos de agar y sacarosa. Las anormalidades más frecuentes en meiosis I fueron: quiasmas persistentes entre homólogos grandes y desplazamiento precoz de cromosomas pequeños, uno o má...

Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study.

Science.gov (United States)

Bhardwaj, Anuj; Ballal, Suma; Velmurugan, Natanasabapathy

2012-07-01

A comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain, and aloe vera (all in gel formulations), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis-an in vitro study. The antimicrobial efficacy was assessed in vitro using dentin shavings collected at 2 depths of 200 and 400 μm. The total colony forming units at the end of 1, 3, and 5 days were assessed. The overall percentage inhibition of bacterial growth (200 and 400 μm depth) was 100% with chlorhexidine gel. This was followed by M. citrifolia gel (86.02%), which showed better antimicrobial efficacy as compared with aloe vera gel (78.9%), papain gel (67.3%), and calcium hydroxide (64.3%). There was no statistical difference between data at 200 and 400 μm depth. Chlorhexidine gel showed the maximum antimicrobial activity against E. faecalis, whereas calcium hydroxide showed the least. Among the natural intracanal medicaments, M. citrifolia gel consistently exhibited good inhibition up to the 5(th) day followed by aloe vera gel and papain gel.

Responses of broilers to Aloe vera bioactives as feed additive: The effect of different forms and levels of bioactives on performances of broilers

Directory of Open Access Journals (Sweden)

A.P Sinurat

2002-06-01

Full Text Available Feed additives are commonly used in poultry feed as growth promotors or to improve feed efficiency. Previous results showed that Aloe vera bioactives could improve feed efficiency in broilers. Therefore, a further study was designed in order to obtain optimum doses and application methods of bioactives for broiler chickens. Aloe vera was prepared in different forms (fresh gel, dry gel, fresh whole leaf or dry whole leaf. The aloe was supplemented into the feed with concentrations of 0.25; 0.5 and 1 g/kg (equal to dry gel. Standard diets with or without antibiotics were also included as control. The diets were fed to broilers from day old to 5 weeks and the performances were observed. Results showed that the aloe-bioactives did not significantly (P>0.05 affect final body weight of broilers as compared with the control. Supplementation of 0.25 g/kg fresh gel, 0.25 and 1.0 g/kg dry gel significantly improved feed convertion by 4.7; 4.8 and 8.2%, respectively as compared with the control. This improvement was a result of reduction in feed intake or dry matter intake without reducing the weight gain. However, supplementation of whole aloe leafs could not improve feed convertion in boilers. It is concluded that the bioactives of Aloe vera could be used as feed supplement to improve feed efficiency in broilers with no deleterious effect on weight gain, carcass yield, abdominal fat levels and internal organs. The effective concentrations of aloe gell as a feed supplement based on dry matter convertion were from 0.25 g/kg fresh gel, 0.25 and 1.0 g/kg dry gel.

PIXE measurements of Renaissance silverpoint drawings at VERA

Energy Technology Data Exchange (ETDEWEB)

Milota, Petra [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Reiche, Ina; Duval, Alain [Centre de recherche et de restauration des musees de France (C2RMF), CNRS UMR 171, Palais du Louvre, F-75001 Paris (France); Forstner, Oliver [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Guicharnaud, Helene [Centre de recherche et de restauration des musees de France (C2RMF), CNRS UMR 171, Palais du Louvre, F-75001 Paris (France); Kutschera, Walter [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Merchel, Silke [Centre Europeen de Recherche et d' Enseignement des Geosciences de l' Environnement (CEREGE), CNRS UMR 6635, F-13545 Aix en Provence (France); Priller, Alfred [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Schreiner, Manfred [Institute of Science and Technology in Art, Academy of Fine Arts Vienna, A-1010 Vienna (Austria); Steier, Peter [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Thobois, Elisabeth [Albertina, Albertinaplatz 1, A-1010 Vienna (Austria); Wallner, Anton; Wuenschek, Barbara [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria); Golser, Robin [Faculty of Physics, Isotope Research, University of Vienna, A-1090 Vienna (Austria)], E-mail: robin.golser@univie.ac.at

2008-05-15

Silverpoint drawings from the Renaissance are among the most precious and rarest treasures of graphical art. Our research group is particularly interested in the analysis of silverpoint drawings by Albrecht Duerer (1471-1528). A very sensitive and non-destructive analytical method, either spatially resolved synchrotron-radiation induced X-ray fluorescence (SY-XRF) or proton-induced X-ray emission (PIXE), is needed to determine the chemical composition of the very faint silver marks on such drawings. Duerer drawings from the collection of the Albertina, Vienna, were analyzed to amend existing data on Duerer drawings. For this purpose an external-beam PIXE setup was installed at the Vienna Environmental Research Accelerator (VERA). It allows to analyze a spot of {approx}0.15 mm on the object in air with 3 MeV protons, and to detect the emitted X-rays that are characteristic for the chemical composition with very good sensitivity and without harming the precious objects. After successful measurements on artificial test samples, four original silverpoint drawings were investigated: two portraits from Albrecht Duerer's very early period (self-portrait and portrait of his father) and two drawings from Duerer's sketch book of his travel to the Netherlands 1520/21.

VERA Pin and Fuel Assembly Depletion Benchmark Calculations by McCARD and DeCART

Energy Technology Data Exchange (ETDEWEB)

Park, Ho Jin; Cho, Jin Young [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

Monte Carlo (MC) codes have been developed and used to simulate a neutron transport since MC method was devised in the Manhattan project. Solving the neutron transport problem with the MC method is simple and straightforward to understand. Because there are few essential approximations for the 6- dimension phase of a neutron such as the location, energy, and direction in MC calculations, highly accurate solutions can be obtained through such calculations. In this work, the VERA pin and fuel assembly (FA) depletion benchmark calculations are performed to examine the depletion capability of the newly generated DeCART multi-group cross section library. To obtain the reference solutions, MC depletion calculations are conducted using McCARD. Moreover, to scrutinize the effect by stochastic uncertainty propagation, uncertainty propagation analyses are performed using a sensitivity and uncertainty (S/U) analysis method and stochastic sampling (S.S) method. It is still expensive and challenging to perform a depletion analysis by a MC code. Nevertheless, many studies and works for a MC depletion analysis have been conducted to utilize the benefits of the MC method. In this study, McCARD MC and DeCART MOC transport calculations are performed for the VERA pin and FA depletion benchmarks. The DeCART depletion calculations are conducted to examine the depletion capability of the newly generated multi-group cross section library. The DeCART depletion calculations give excellent agreement with the McCARD reference one. From the McCARD results, it is observed that the MC depletion results depend on how to split the burnup interval. First, only to quantify the effect of the stochastic uncertainty propagation at 40 DTS, the uncertainty propagation analyses are performed using the S/U and S.S. method.

Evaluation of inter-specific hybrid of P. atlantica and P. vera L. cv. ‘Badami Riz-e-Zarand’ as pistachio rootstock to salinity stress according to some growth indices and eco-physiological and biochemical parameters

OpenAIRE

Karimi, Hamid; MALEKI-KUHBANANI; Roosta, H.

2014-01-01

In order to evaluate the inter-specific hybrid of P. atlantica Desf. and P. vera L. cv. ‘Badami- Riz-e- Zarand’ to salinity stress, a factorial experiment was conducted based on completely randomized design with 0, 60 and 120 mM of salinity levels of sodium chloride, calcium chloride and magnesium chloride (3:2:1) with four replications on ‘Qazvini’, ‘Badami-Riz-e-Zarand’ and inter-specific of P. atlantica Ч P. vera cv. ‘Badami-Rize-Zarand’ rootstocks of pistachio. The results showed that sa...

Aloe vera: an in vitro study of effects on corneal wound closure and collagenase activity.

Science.gov (United States)

Curto, Elizabeth M; Labelle, Amber; Chandler, Heather L

2014-11-01

To evaluate the in vitro effects of an aloe vera solution on (i) the viability and wound healing response of corneal cells and (ii) the ability to alter collagenase and gelatinase activities. Primary cultures of corneal epithelial cells and fibroblasts were prepared from grossly normal enucleated canine globes and treated with an aloe solution (doses ranging from 0.0-2 mg/mL). Cellular viability was evaluated using a colorimetric assay. A corneal wound healing model was used to quantify cellular ingrowth across a defect made on the confluent surface. Anticollagenase and antigelatinase activities were evaluated by incubating a bacterial collagenase/gelatinase with aloe solution (doses ranging from 0.0-500 μg/mL) and comparing outcome measures to a general metalloproteinase inhibitor, 1, 10-phenanthroline, and canine serum (doses ranging from 0.0-100%). None of the concentrations of aloe solution tested significantly affected the viability of corneal epithelial cells or fibroblasts. Concentrations ≤175 μg/mL slightly accelerated corneal epithelial cell wound closure; this change was not significant. Concentrations ≥175 μg/mL significantly (P ≤ 0.001) slowed the rate of corneal fibroblast wound closure, while aloe concentrations Aloe solution did not alter the ability for collagenase to degrade gelatin or collagen Type I but increased the ability for collagenase to degrade Type IV collagen. Although additional experiments are required, lower concentrations of aloe solution may be beneficial in healing of superficial corneal wounds to help decrease fibrosis and speed epithelialization. An increase in collagenase activity with aloe vera warrants further testing before considering in vivo studies. © 2014 American College of Veterinary Ophthalmologists.

Histopathology as biomarkers: in treated mouse brain with radiation, cadmium and therapeutic agents (Aloe Vera)

International Nuclear Information System (INIS)

Chakrawarti, Aruna; Kanwar, Om; Nayak, Kamal Kumar; Ranga, Deepti

2014-01-01

There are two different types of radiation energetic particles and electromagnetic waves. These two types can penetrate into living tissue or cell and result in transduction of radiation energy to biological materials. The absorbed energy of ionising radiation can break chemical bonds and cause ionization of different molecules including water and different biological essential macromolecules of as DNA, membrane lipids and protein. Many types of DNA lesions are produce in cell by ionizing radiation and chemicals during cancer therapy. Cadmium is known to deplete glutathione and protein bounds sulfhydrl groups which results in enhance production of reactive oxygen species (ROS). The reactions of these ROS with cellular biomolecules have been shown to lead to lipid per-oxidation. Aloe vera is dietary antioxidant that plays an important role in controlling oxidative stress. For this purpose, six to eight weeks old male Swiss albino mice (Mus musculus) were randomly divided into seven groups. On the basis of radiation, cadmium, combined treatment and Aloe treated groups the animals were sacrificed at each post treatment intervals of 1, 2, 4, 7, 14 and 28 days. The brain were taken out and weighed to the analytical balance and fixed for 24 hours in alcoholic Bouin's fixative. A pinch of lithium carbonate was added to remove excess picric acid in the fixative. Histological studies were carried out using the standard techniques of haematoxyline and eosin staining. After combined treatment of radiation and cadmium chloride synergistic changes were observed. These changes were less severe in the Aloe vera treated brain which may be due to the protection provided by drug

Quantitative analysis of the erythrocyte membrane proteins in polycythemia vera patients treated with hydroxycarbamide

Directory of Open Access Journals (Sweden)

Darshana Kottahachchi

2015-06-01

Full Text Available More than 90% of polycythemia vera (PV patients have a mutation in the protein JAK2, which is closely associated with the erythrocyte membrane. With the comparison of 1-D gels of erythrocyte membranes obtained from PV patients treated with hydroxycarbamide and those of untreated controls we observed significant differences in the region of 40–55 kDa. On the basis of the LC–MS/MS analysis of this region we report up-regulation of four protein disulfide isomerases, which was subsequently confirmed by targeted mass spectrometric analysis. In further studies it will be prudent to compare this in patients both treated and not treated with hydroxycarbamide.

Analysis of genetic diversity of Tunisian pistachio (Pistacia vera L.) using sequence-related amplified polymorphism (SRAP) markers.

Science.gov (United States)

Guenni, K; Aouadi, M; Chatti, K; Salhi-Hannachi, A

2016-10-17

Sequence-related amplified polymorphism (SRAP) markers preferentially amplify open reading frames and were used to study the genetic diversity of Tunisian pistachio. In the present study, 43 Pistacia vera accessions were screened using seven SRAP primer pairs. A total of 78 markers was revealed (95.12%) with an average polymorphic information content of 0.850. The results suggest that there is strong genetic differentiation, which characterizes the local resources (G ST = 0.307). High gene flow (N m = 1.127) among groups was explained by the exchange of plant material among regions. Analysis of molecular variance revealed significant differences within groups and showed that 73.88% of the total genetic diversity occurred within groups, whereas the remaining 26.12% occurred among groups. Bayesian clustering and principal component analysis identified three pools, El Guettar, Pollenizers, and the rest of the pistachios belonging to the Gabès, Kasserine, and Sfax localities. Bayesian analysis revealed that El Guettar and male genotypes were assigned with more than 80% probability. The BayeScan method proposed that locus 59 (F13-R9) could be used in the development of sex-linked SCAR markers from SRAP since it is a commonly detected locus in comparisons involving the Pollenizers group. This is the first application of SRAP markers for the assessment of genetic diversity in Tunisian germplasm of P. vera. Such information will be useful to define conservation strategies and improvement programs for this species.

Biochemical Study on the Effect of Aloe vera (Latex and Leaves) as a Dietary Supplement to Rats Exposed to Gamma Radiation and/or Aluminum

International Nuclear Information System (INIS)

Eltahawy, N. A.; Saada, H.N.; Sayed, R.M.; Abdallah, N.M.; Abdel Hamid, F. F.

2016-01-01

Aluminum (Al) and/or gamma (γ) - radiation (IR), are neuro toxicant, have been implicated in the pathogenesis of neuro degenerative disorders. The present study was undertaken to evaluate the possible protective role of Aloe Vera Latex and Leaves (AV) as natural antioxidant on exposure of Al and/or IR-induced brain oxidative damage and toxicity. A total of forty-eight healthy adult male rats were divided into eight groups: Group (control), Group II (AV alone 200 mg/kg body weight orally daily for 4 weeks), Group III (irradiated 8Gy; 2Gy/ week for 4 weeks), Group IV(Both irradiated and AV treated), Group V(Al-sulphate alone, 0.2 mg/ kg body weight orally daily for 4 weeks), Group VI (Both AV and Al- sulphate treated), Group VII (Both irradiated and Al-sulphate treated) and Group VIII (irradiated and both AV and Al-sulphate treated). The results of the present study clearly indicated that Al-sulphate and/or γ-radiation have significantly altered the normal levels of aluminum, Lipid peroxides, monoamines neurotransmitters; serotonin and its metabolite and glutathione levels of rat brain. The activity of brain antioxidant enzymes were found to be highly decreased associated with significant increase in monoamine oxidase activity in both the aluminum and irradiated treated groups. Severe changes were observed after combined exposure to radiation and Al-sulphate showing synergistic effect. Treatment with A. vera revealed an improvement in the neurological damage induced by Al-sulphate and/or radiation as indicated by improvement in most of the biochemical markers. In conclusion A. vera appears to have protective role against the synergistic action of aluminium and/or radiation induced brain toxicity

Effect of Eight Weeks High Intensity Interval Training and Medium Intensity Interval Training and Aloe vera Intake on Serum Vaspin and Insulin Resistance in Diabetic Male Rats

Directory of Open Access Journals (Sweden)

Darya Asgari Hazaveh

2018-02-01

Full Text Available Abstract Background: The use of herbal supplements and exercise training for the treatment of diabetic has increased.The purpose of this study was to investigate the effect of eight weeks high intensity interval training and moderate intensity interval training and Aloe vera intake on serum vaspin and insulin resistance in diabetic male rats. Materials and Methods: During this experimental study, 32 diabetic rats with STZ Wistar were randomly divided into four groups including the control, high intensity interval training +supplement, moderate intensity interval training + supplement and supplement. Training program was planned for 8 weeks and 3 sessions per week. Each session consisted of 6 to 12 periods of 2-minute activity with the intensity of 90% and 60% with one minute rest (speed: 10m/min. In the supplement groups, 300milligrams Aloe vera solution per kilogram of body weight Gavage was given 5 sessions per week for 8 weeks. The data were analyzed using one-way analysis of variance (ANOVA. Results: The results showed that high and moderate intensity interval training with supplement has no significant effect on the of serum vaspin (p=0.112. High intensity interval training with supplement had significant effects on insulin in diabetic male rats (0.000. Conclusion: .Based on the findings of this study, it seems that supplementation of Aloe vera with high intensity interval training can have better effects on serum insulin in diabetic rats.

Treatment of polycythaemia vera by radiophosphorus or busulphan: a randomized trial

International Nuclear Information System (INIS)

Haanen, C.; Mathe, G.; Hayat, M.

1981-01-01

Between 1967 and 1978 a Phase III cooperative study was performed in polycythaemia vera (PCV) patients who had not been treated previously with any specific therapy other than phlebotomy. 293 patients were included and allocated at random for either radiophosphorus therapy (146) or busulphan treatment (147). Additional phlebotomies were indicated in both groups, to keep the haematocrit at 42-47%. 285 patients were evaluable after the study was completed, of whom 50% have an 8-year follow-up. Both groups were comparable with respect to age, clinical symptoms and haematological parameters immediately before randomization. The duration of the first remission and the overall survival were significantly better in the busulphan group. This difference remains significant after correction for differences between the two groups with respect to sex-ratio and phlebotomy before the start of therapy. Busulphan induced a longer first remission (P < 0.001) and a longer overall survival (P < 0.02). (author)

Presence of calreticulin mutations in JAK2-negative polycythemia vera.

Science.gov (United States)

Broséus, Julien; Park, Ji-Hye; Carillo, Serge; Hermouet, Sylvie; Girodon, François

2014-12-18

Calreticulin (CALR) mutations have been reported in Janus kinase 2 (JAK2)- and myeloproliferative leukemia (MPL)-negative essential thrombocythemia and primary myelofibrosis. In contrast, no CALR mutations have ever been reported in the context of polycythemia vera (PV). Here, we describe 2 JAK2(V617F)-JAK2(exon12)-negative PV patients who presented with a CALR mutation in peripheral granulocytes at the time of diagnosis. In both cases, the CALR mutation was a 52-bp deletion. Single burst-forming units-erythroid (BFU-E) from 1 patient were grown in vitro and genotyped: the same CALR del 52-bp mutation was noted in 31 of the 37 colonies examined; 30 of 31 BFU-E were heterozygous for CALR del 52 bp, and 1 of 31 BFU-E was homozygous for CALR del 52 bp. In summary, although unknown mutations leading to PV cannot be ruled out, our results suggest that CALR mutations can be associated with JAK2-negative PV. © 2014 by The American Society of Hematology.

Uso de cobertura com colágeno e aloe vera no tratamento de ferida isquêmica: estudo de caso El uso de colágeno y aloe vera en el tratamiento de la herida isquémica: estudio de caso Use of collagen and aloe vera in ischemic wound treatment: study case

Directory of Open Access Journals (Sweden)

Simone Helena dos Santos Oliveira

2010-06-01

Full Text Available O presente estudo relata o caso clínico de um paciente diabético e hipertenso, portador de ferida isquêmica, tratado com cobertura não convencional, à base de Aloe vera e colágeno. Faz parte de um projeto de pesquisa experimental, coordenado por professores e enfermeiros que atuam em projetos para o desenvolvimento de novas tecnologias para o tratamento de feridas. O caso em tela foi selecionado dentre os dos demais pacientes acompanhados. A coleta de dados foi efetuada através da anamnese e exame físico do paciente, utilizando-se um instrumento com dados relativos às condições do paciente e da lesão, bem como através do registro fotográfico da lesão. Os curativos foram realizados diariamente e, ao final de aproximadamente dez semanas, observou-se a total cicatrização da lesão. Não foram observados desconfortos ou complicações decorrentes do uso do produto, concluindo-se que o mesmo apresentou boa tolerabilidade e eficácia terapêutica para este caso em particular.Este estudio reporta el caso clínico de un paciente hipertenso, diabético, con una herida isquémica tratada con apósitos no convencionales de Aloe vera y colágeno, y forma parte de un proyecto de investigación experimental coordinado por profesores y enfermeros que trabajan en proyectos de desarrollo de nuevas tecnologías para el tratamiento de heridas. El caso de referencia fue elegido entre muchos pacientes en seguimiento. Los datos fueron obtenidos por la anamnesis y el examen físico del paciente, utilizándose un instrumento con datos relativos a las condiciones del paciente y de la lesión, así como un registro fotográfico de la lesión. Las curaciones se realizaron diariamente, al cabo de aproximadamente diez semanas se obtuvo la curación total. No se observó incomodidad o cualquier otra complicación derivada de la utilización del producto, por lo que se concluye en que el tratamiento demostró una buena tolerabilidad y eficacia terap

Pistachio (Pistacia vera seed oil composition: geographic situation and variety effects

Directory of Open Access Journals (Sweden)

Chahed, T.

2008-03-01

Full Text Available This study was aimed at characterizing four Tunisian pistachio cultivations (Pistacia vera from the Mateur (North, Nabeul (North-East, Kairouan (Middle and Sfax (Middle- East regions and two varieties, Mateur and Ohadi, considering fatty acid composition and main lipid class contents (polar lipids, diacylglycerols, triacylglycerols and free fatty acids in ripe seeds. Lipid classes were separated using thin layer chromatography, and fatty acid methyl esters (FAMEs were analyzed by gas chromatography. Oleic acid (C18:1 Δ9 was the major fatty acid for all samples; those of the Mateur region (the northern region differed significantly with the lowest content in C18:1 (54.2 % of total fatty acids and the highest in C18:2 (24.1 %. The total amount of fatty acids (TFA in the seeds of Ohadi variety was significantly lower than that of the Mateur variety from the Sfax region. Triacylglycerols were most abundant in pistachio seeds from Nabeul (98.5% of total glycerolipids.Este estudio tiene como objetivo caracterizar cuatro cultivos de pistacho (Pistacia vera de Túnez, de las regiones de Mateur (Norte, Nabeul (Nordeste, Kairouan (Centro y Sfax (Centro-Este y dos variedades, Mateur and Ohadi, considerando la composición en ácidos grasos y de lípidos mayoritarios (lípidos polares, diglicéridos, triglicéridos y ácidos grasos libres de semillas maduras. Los lípidos se separaron mediante cromatografía en capa fina, y los ésteres metílicos de los ácidos grasos (FAMEs se analizaron por cromatografía de gases. El ácido oleico (C18:1 Δ9 fue el mayoritario en todas las muestras; las de la región de Mateur (Norte fueron significativamente distintas, presentando el contenido más bajo de C18:1 (54.2 % del total de ácidos grasos y más alto de C18:2 (24.1 %. La cantidad total de ácidos grasos (TFA en las semillas de la variedad Ohadi fue significativamente más bajo que el de la variedad Mateur de la región de Sfax. Los triglicéridos fueron

Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts.

Science.gov (United States)

Mirian, M; Behrooeian, M; Ghanadian, M; Dana, N; Sadeghi-Aliabadi, H

2015-01-01

Angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. Using angiogenesis inhibitors, therefore, is one of the ways for cancer treatment and prevention of metastasis. Medicinal plants have been shown to play a major role in the treatment of a variety of cancers. In this direction, cytotoxic and angiogenic effects of oleo gum resin extracts of Rhus coriaria, Pistacia vera and Pistacia khinjuk from Anacardiaceae family were studied. For IC50 values, cytotoxic effects of the plant extracts were evaluated at different concentrations (1, 10, 20, 40, 80,100 μg/ml) against human umbilical vein endothelial normal cell (HUVEC) and Y79 cell lines using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. In vitro tube formation on matrigel base was used to evaluate angiogenic effects in the presence of increasing concentrations (50, 100, 250 μg/ml) of the extracts. Vascular endothelium growth factor was used as angiogenesis stimulator. Gas chromatography results showed that α-pinene and β-pinene were the major essential oils constituents of all plant extracts. According to the MTT assay results, the R. coriaria resin extract was more cytotoxic than those of P. vera and P. khinjuk extracts (IC50, 9.1 ± 1.6 vs 9.8 ± 2.1 and 12.0 ± 1.9, respectively; P<0.05). Cytotoxic effects of all extracts against Y79 cell line was significantly higher than those of HUVEC used as a normal cell line (P<0.05). Tube formation assay also showed that extract of R. coriaria resin inhibited angiogenesis more significantly than other tested extracts (P<0.05). It could be concluded that R. coriaria resin extract possess cytotoxic effect and antiangiogenesis against cancer cells and as an anticancer natural product has a good potential for future studies.

Green clay and aloe vera peel-off facial masks: response surface methodology applied to the formulation design.

Science.gov (United States)

O'Reilly Beringhs, André; Rosa, Julia Macedo; Stulzer, Hellen Karine; Budal, Rosane Maria; Sonaglio, Diva

2013-03-01

This article describes the optimization of a peel-off facial mask formulation. An investigation was carried out on the parameters of the formulation that most affect the desirable characteristics of peel-off facial masks. Cereal alcohol had a significant effect on the drying time at concentrations of 1-12% (w/w). The applicability of the evaluated formulations was influenced by both carbomer (0-2.4%; w/w) and polyvinyl alcohol (PVA; 2.5-17.5%; w/w) content due to their ability to alter the formulation viscosity. Inverse concentrations of carbomer and PVA led to formulations with optimum viscosity for facial application. Film-forming performance was influenced only by the PVA concentration, achieving maximum levels at concentrations of around 11% (w/w). The optimized formulation, determined mathematically, contained 13% (w/w) PVA and 10% (w/w) cereal alcohol with no addition of carbomer. This formulation provided high levels of applicability and film-forming performance, the lowest drying time possible and excellent homogeneity of the green clay particles and aloe vera before and after drying. The preliminary stability study indicated that the optimized formulation is stable under normal storage conditions. The microbiological stability evaluation indicated that the preservative was efficient in terms of avoiding microbial growth. RSM was shown to be a useful statistical tool for the determination of the behavior of different compounds and their concentrations for the responses studied, allowing the investigation of the optimum conditions for the production of green clay and aloe vera peel-off facial masks.

A genome-wide transcriptome map of pistachio (Pistacia vera L.) provides novel insights into salinity-related genes and marker discovery.

Science.gov (United States)

Moazzzam Jazi, Maryam; Seyedi, Seyed Mahdi; Ebrahimie, Esmaeil; Ebrahimi, Mansour; De Moro, Gianluca; Botanga, Christopher

2017-08-17

Pistachio (Pistacia vera L.) is one of the most important commercial nut crops worldwide. It is a salt-tolerant and long-lived tree, with the largest cultivation area in Iran. Climate change and subsequent increased soil salt content have adversely affected the pistachio yield in recent years. However, the lack of genomic/global transcriptomic sequences on P. vera impedes comprehensive researches at the molecular level. Hence, whole transcriptome sequencing is required to gain insight into functional genes and pathways in response to salt stress. RNA sequencing of a pooled sample representing 24 different tissues of two pistachio cultivars with contrasting salinity tolerance under control and salt treatment by Illumina Hiseq 2000 platform resulted in 368,953,262 clean 100 bp paired-ends reads (90 Gb). Following creating several assemblies and assessing their quality from multiple perspectives, we found that using the annotation-based metrics together with the length-based parameters allows an improved assessment of the transcriptome assembly quality, compared to the solely use of the length-based parameters. The generated assembly by Trinity was adopted for functional annotation and subsequent analyses. In total, 29,119 contigs annotated against all of five public databases, including NR, UniProt, TAIR10, KOG and InterProScan. Among 279 KEGG pathways supported by our assembly, we further examined the pathways involved in the plant hormone biosynthesis and signaling as well as those to be contributed to secondary metabolite biosynthesis due to their importance under salinity stress. In total, 11,337 SSRs were also identified, which the most abundant being dinucleotide repeats. Besides, 13,097 transcripts as candidate stress-responsive genes were identified. Expression of some of these genes experimentally validated through quantitative real-time PCR (qRT-PCR) that further confirmed the accuracy of the assembly. From this analysis, the contrasting expression pattern

Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients

Science.gov (United States)

Yagi, Akira; Hegazy, Sahar; Kabbash, Amal; Wahab, Engy Abd-El

2009-01-01

Aloe vera L. high molecular weight fractions (AHM) containing less than 10 ppm of barbaloin and polysaccharide (MW: 1000 kDa) with glycoprotein, verectin (MW: 29 kDa), were prepared by patented hyper-dry system in combination of freeze–dry technique with microwave and far infrared radiation. AHM produced significant decrease in blood glucose level sustained for 6 weeks of the start of the study. Significant decrease in triglycerides was only observed 4 weeks after treatment and continued thereafter. No deterious effects on kidney and liver functions were apparent. Treatment of diabetic patients with AHM may relief vascular complications probably via activation of immunosystem. PMID:23964163

Polycythemia vera treated with /sup 32/P and myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient

Energy Technology Data Exchange (ETDEWEB)

Stavem, P; Sandnes, K [Rikshospitalet, Oslo (Norway); Hagen, C.B. van der [Oslo Univ. (Norway); Vogt, E [Statens Institutt for Folkehelse, Oslo, Norway

1975-01-01

Chronic granulocytic leukemia developed in a 59-year-old woman who had previously received a total of 21 mCl /sup 32/P for polycythemia vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenetic studies revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe autoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer. (INIS)

Interaction of phosphorus and pistachio green hull on some growth characteristics and nutrients in pistachio (Pistacia vera L.) seedlings

OpenAIRE

M. Fekri; L. Gheranjik

2015-01-01

To investigate the effects of phosphorus (P) and pistachio waste (raw and dry) on growth and chemical composition of pistachio (Pistacia vera L. cv. Badami Zarand) seedlings, a factorial experiment in a completely randomized design with four replications was conducted. Treatments were three levels of P (0, 50 and 100 mg P/kg soil) and three levels of pistachio green hull (0, 3 and 6% w/w). The results showed that at the first level of P application, the 3% pistachio waste treatment increased ...

VERA observations of the Galactic star-forming regions ON1 and ON2N

Science.gov (United States)

Nagayama, Takumi

2013-02-01

We carried out astrometric observations with VERA of H2O masers in ON1 and ON2N. The measured distances to ON1 and ON2N are 2.47 +/- 0.11 and 3.83 +/- 0.13 kpc, respectively. We found that ON1 and ON2N are located near the tangent point and the Solar circle, respectively. We derive an angular velocity of the Galactic rotation at the Sun's position (i.e. the ratio of the Galactic constants) of 28 +/- 2 km s-1 kpc-1 using the measured distances and three-dimensional velocity components of the two sources. This value is consistent with recent estimates obtained using Very Long Baseline Interferometry but different from the IAU-recommended value of 25.9 km s-1 kpc-1.

Removal of reactive dyes from aqueous solutions by a non-conventional and low cost agricultural waste: adsorption on ash of Aloe Vera plant

Directory of Open Access Journals (Sweden)

Mohammad Malakootian

2014-08-01

Full Text Available Dyes are an important class of pollutants and disposal of them in precious water resources must be avoided. Among various methods adsorption occupies a prominent place in dye removal. The aim of this study is to evaluate adsorption of dye Reactive Red 198 and Blue 19 (RR-198 & RB-19 (on to Aloe Vera plant ash from aqueous solutions. In this research Aloe Vera ash was prepared at laboratory conditions and then after shredding, screened by ASTM standard sieve with 60 -200 mesh sizes and the effects of pH (3-12, adsorbent dose (0.1-1 g/L, contact time (10-60 min, initial dye concentration (10-160 mg/L and temperature were investigated in the experiment. In different samples Dye concentration was measured by spectrophotometer at 592 nm and 520 nm wavelength for RR198 and RB19 respectively. Also the Langmuir and Freundlich adsorption isotherms were determined in order to describe the relations between the colored solutions and the adsorbent. The results of this study showed that acidic conditions were more conducive to enhance the hydrolysis rate than basic ones as the decomposition was optimum at pH 3. The adsorption rate of RR-198 and RB-19 dyes was increased by increasing of initial dye concentration, increasing of adsorbent dose in 0.1 to 0.4 mg/L. Dye solution was decolorized in a relatively short time (20 min. The efficiencies for RR-198 and RB- 19 reactive dyes were 82.68% and 90.42% respectively. The maximum adsorption capacity (qmax has been found to be 80.152 mg/g for RR-198 reactive dye and 88.452 mg/g for Blue 19 reactive dye. Adsorption isotherms were examined by Freundlich and Langmuir isotherm that finally showed the Freundlich multilayer isotherm has better accordance with dates. The results indicate that Aloe Vera ash plant as a natural and inexpensive adsorbent is a suitable adsorbent for the adsorption of textile dyes.

Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds.

Science.gov (United States)

Panahi, Y; Izadi, M; Sayyadi, N; Rezaee, R; Jonaidi-Jafari, N; Beiraghdar, F; Zamani, A; Sahebkar, A

2015-10-01

Aloe vera is a medicinal plant that has been traditionally used to accelerate wound healing. Olive oil is also a natural product that may contribute to wound healing owing to its antimicrobial and anti-inflammatory effects. The present study aimed to evaluate the effect of an Aloe vera-olive oil (AVO) combination cream on the healing process of chronic wounds. In this randomised, double-blind, comparator-controlled, parallel-group trial, patients with chronic wounds were treated with either AVO cream or phenytoin cream as the standard treatment for a period of 30 days. Wound healing was evaluated using Bates-Jensen assessment tool and the severity of pain was assessed using a visual analogue scale (VAS). After initial assessment, 60 patients with chronic wounds (41 with pressure ulcer, 13 with diabetic wounds and 6 with venous ulcers), were recruited and randomised into 2 groups of 30. After 30 days of treatment, significant improvements in the wound size, depth, and edges; necrotic tissue type and amount; exudate type and amount; colour of wound surroundings; and peripheral tissue oedema score were observed in the AVO cream group (p<0.001). The total score of wound healing showed significant improvement with both AVO (p<0.001) and phenytoin (p<0.01) creams, although AVO was more efficacious (p<0.001). Likewise, although both treatments reduced the initial VAS score, the efficacy of AVO was significantly greater (p<0.001). AVO cream significantly accelerates biological healing of chronic wounds and helps to reduce pain severity with a higher efficacy compared with phenytoin cream.

Encountering epidemic effects of leaf spot disease (Alternaria brassicae) on Aloe vera by fungal biocontrol agents in agrifields-An ecofriendly approach.

Science.gov (United States)

Ghosh, Swapan Kumar; Banerjee, Subhankar; Pal, Sujoy; Chakraborty, Niloy

2018-01-01

Aloe vera (L.) Burm.f. is a highly important and extensively cultivated medicinal plant and that is also extensively used in the cosmetic industry. It has been frequently reported to suffer from Alternaria leaf spot disease in various parts of the world. Various fungicides used to combat this disease, have deleterious effects on the environment and on pharmacologically important constituents of Aloe vera. To avoid the harmful effects of fungicides an ecofriendly approach has been adopted here. A weekly survey was conducted during 2013-2015 in and around North 24 Parganas (West Bengal) to obtain the percentage of disease index (PDI). For biological control of the disease, screening of the antagonistic efficacy of biocontrol agents was carried out through the in vitro dual-culture-plate method and scanning electron microscopy (SEM) was used to study the mechanism. The in vitro effects of fungicides on the radial growth of the pathogen were evaluated through the poison food method and were compared with potent antagonistic fungi. Field application of potent antagonistic fungi was conducted through the dip-and-spray method. The results showed that, the PDI peaked during the hot and humid conditions of May to September (76.57%-98.57%) but decreased during the winter, December-January (35.71-46.66%). Trichoderma asperellum exerted the greatest inhibition of the radial growth of A. brassicae acting through non volatile (70.39%) and volatile metabolites (72.17%). A SEM study confirmed the hyperparasitic nature of T. asperellum through hyphal coiling-T. asperellum was similar to 2% blitox-50 (73.92%) and better than 2% bavistin (59.77%) (in vitro). In agricultural field trials (2013-15), Trichoderma application restricted the disease to the smallest area (PDI 24.00-29.33%) in comparison to untreated plots (73.33%). In conclusion, saplings treated with the dip method (108 spores / mL) and sprayed 4 times with a spore suspension of biocontrol agents such as T. asperellum, T

Effects of water stress and light intensity on chlorophyll fluorescence parameters and pigments of Aloe vera L.

Science.gov (United States)

Hazrati, Saeid; Tahmasebi-Sarvestani, Zeinolabedin; Modarres-Sanavy, Seyed Ali Mohammad; Mokhtassi-Bidgoli, Ali; Nicola, Silvana

2016-09-01

Aloe vera L. is one of the most important medicinal plants in the world. In order to determine the effects of light intensity and water deficit stress on chlorophyll (Chl) fluorescence and pigments of A. vera, a split-plot in time experiment was laid out in a randomized complete block design with four replications in a research greenhouse. The factorial combination of three light intensities (50, 75 and 100% of sunlight) and four irrigation regimes (irrigation after depleting 20, 40, 60 and 80% of soil water content) were considered as main factors. Sampling time was considered as sub factor. The first, second and third samplings were performed 90, 180 and 270 days after imposing the treatments, respectively. The results demonstrated that the highest light intensity and the severe water stress decreased maximum fluorescence (Fm), variable fluorescence (Fv)/Fm, quantum yield of PSII photochemistry (ФPSII), Chl and photochemical quenching (qP) but increased non-photochemical quenching (NPQ), minimum fluorescence (F0) and Anthocyanin (Anth). Additionally, the highest Fm, Fv/Fm, ФPSII and qP and the lowest NPQ and F0 were observed when 50% of sunlight was blocked and irrigation was done after 40% soil water depletion. Irradiance of full sunlight and water deficit stress let to the photoinhibition of photosynthesis, as indicated by a reduced quantum yield of PSII, ФPSII, and qP, as well as higher NPQ. Thus, chlorophyll florescence measurements provide valuable physiological data. Close to half of total solar radiation and irrigation after depleting 40% of soil water content were selected as the most efficient treatments. Copyright © 2016 Elsevier Masson SAS. All rights reserved.