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Sample records for sa onset relative

  1. Effects of Age, Gender, Bolus Volume, Bolus Viscosity, and Gustation on Swallowing Apnea Onset Relative to Lingual Bolus Propulsion Onset in Normal Adults

    Science.gov (United States)

    Hiss, Susan G.; Strauss, Monica; Treole, Kathleen; Stuart, Andrew; Boutilier, Susan

    2004-01-01

    The purpose of this study was to ascertain the normal relation of swallowing apnea (SA) onset relative to lingual bolus propulsion along with factors that may alter this relation. Forty adults, composed of 10 men and 10 women in each of 2 age groups (i.e., 20-30 and 63-79 years) participated. SA onset was assessed during 5- and 20-ml bolus volumes…

  2. Social relations as determinant of onset of disability in aging

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holstein, Bjørn E; Due, Pernille

    2013-01-01

    The purpose of the study was to analyze whether social relations are related to onset of disability among old people at 1.5 year follow-up and whether these relations vary by age and gender. The study is based on baseline and 1.5 year follow-up data on 1396 older non-disabled adults. Social...... relations were measured by questions about diversity in social relations, social participation, satisfaction with social relations and instrumental social support. Onset of disability was described as developing need of help in at least one of six mobility activities. The results showed that a large...... diversity in social relations and high social participation were important factors for maintaining functional ability among the 75-year-old men and women, while social support was a risk factor for functional decline among the 80-year-old men. The present study suggests that being "embedded" in a strong...

  3. Social relations as determinant of onset of disability in aging

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Lund, Rikke; Holstein, Bjørn E

    2003-01-01

    The purpose of the study was to analyze whether social relations are related to onset of disability among old people at 1.5 year follow-up and whether these relations vary by age and gender. The study is based on baseline and 1.5 year follow-up data on 1396 older non-disabled adults. Social...... relations were measured by questions about diversity in social relations, social participation, satisfaction with social relations and instrumental social support. Onset of disability was described as developing need of help in at least one of six mobility activities. The results showed that a large...... diversity in social relations and high social participation were important factors for maintaining functional ability among the 75-year-old men and women, while social support was a risk factor for functional decline among the 80-year-old men. The present study suggests that being "embedded" in a strong...

  4. Social relations as determinant of onset of disability in aging

    DEFF Research Database (Denmark)

    Avlund, Kirsten; Holstein, Bjørn E; Due, Pernille

    2013-01-01

    The purpose of the study was to analyze whether social relations are related to onset of disability among old people at 1.5 year follow-up and whether these relations vary by age and gender. The study is based on baseline and 1.5 year follow-up data on 1396 older non-disabled adults. Social...... relations were measured by questions about diversity in social relations, social participation, satisfaction with social relations and instrumental social support. Onset of disability was described as developing need of help in at least one of six mobility activities. The results showed that a large...... network of social relations provides protection against disability by reducing risk of developing disability....

  5. Dynamic Onset of Feynman Relation in the Phonon Regime

    Science.gov (United States)

    Li, Y.; Zhu, C. J.; Hagley, E. W.; Deng, L.

    2016-05-01

    The Feynman relation, a much celebrated condensed matter physics gemstone for more than 70 years, predicts that the density excitation spectrum and structure factor of a condensed Bosonic system in the phonon regime drops linear and continuously to zero. Until now, this widely accepted monotonic excitation energy drop as the function of reduced quasi-momentum has never been challenged in a spin-preserving process. We show rigorously that in a light-matter wave-mixing process in a Bosonic quantum gas, an optical-dipole potential arising from the internally-generated field can profoundly alter the Feynman relation and result in a new dynamic relation that exhibits an astonishing non-Feynman-like onset and cut-off in the excitation spectrum of the ground state energy of spin-preserving processes. This is the first time that a nonlinear optical process is shown to actively and significantly alter the density excitation response of a quantum gas. Indeed, this dynamic relation with a non-Feynman onset and cut-off has no correspondence in either nonlinear optics of a normal gas or a phonon-based condensed matter Bogoliubov theory.

  6. Dynamic Onset of Feynman Relation in the Phonon Regime.

    Science.gov (United States)

    Li, Y; Zhu, C J; Hagley, E W; Deng, L

    2016-05-09

    The Feynman relation, a much celebrated condensed matter physics gemstone for more than 70 years, predicts that the density excitation spectrum and structure factor of a condensed Bosonic system in the phonon regime drops linear and continuously to zero. Until now, this widely accepted monotonic excitation energy drop as the function of reduced quasi-momentum has never been challenged in a spin-preserving process. We show rigorously that in a light-matter wave-mixing process in a Bosonic quantum gas, an optical-dipole potential arising from the internally-generated field can profoundly alter the Feynman relation and result in a new dynamic relation that exhibits an astonishing non-Feynman-like onset and cut-off in the excitation spectrum of the ground state energy of spin-preserving processes. This is the first time that a nonlinear optical process is shown to actively and significantly alter the density excitation response of a quantum gas. Indeed, this dynamic relation with a non-Feynman onset and cut-off has no correspondence in either nonlinear optics of a normal gas or a phonon-based condensed matter Bogoliubov theory.

  7. Timing of onset of CKD-related metabolic complications.

    Science.gov (United States)

    Moranne, Olivier; Froissart, Marc; Rossert, Jerome; Gauci, Cedric; Boffa, Jean-Jacques; Haymann, Jean Philippe; M'rad, Mona Ben; Jacquot, Christian; Houillier, Pascal; Stengel, Benedicte; Fouqueray, Bruno

    2009-01-01

    Chronic kidney disease (CKD) guidelines recommend evaluating patients with GFR acidosis from 2 to 39%, and hyperkalemia from 2 to 42%. Factors most strongly associated with metabolic complications, independent of mGFR, were younger age for acidosis and hyperphosphatemia, presence of diabetes for acidosis, diabetic kidney disease for anemia, and both male gender and the use of inhibitors of the renin-angiotensin system for hyperkalemia. mGFR thresholds for detecting complications with 90% sensitivity were 50, 44, 40, 39, and 37 ml/min per 1.73 m(2) for hyperparathyroidism, anemia, acidosis, hyperkalemia, and hyperphosphatemia, respectively. Analysis using estimated GFR produced similar results. In summary, this study describes the onset of CKD-related complications at different levels of GFR; anemia and hyperparathyroidism occur earlier than acidosis, hyperkalemia, and hyperphosphatemia.

  8. Relational Aggression in Children with Preschool Onset (PO) Psychiatric Disorders

    Science.gov (United States)

    Belden, Andy C.; Gaffrey, Michael S.; Luby, Joan L.

    2012-01-01

    Objective The role of preschool onset (PO) psychiatric disorders as correlates and/or risk factors for relational aggression during kindergarten or 1st grade was tested in a sample of N = 146 preschool-age children (3 to 5.11). Method Axis-I diagnoses and symptom scores were derived using the Preschool Age Psychiatric Assessment. Children’s roles in relational aggression as aggressor, victim, aggressive-victim, or non-aggressor/non-victim were determined at preschool and again 24 months later at elementary school entry. Results Preschoolers diagnosed with PO-psychiatric disorders were 3 times as likely as the healthy preschoolers to be classified aggressors, victims, or aggressive-victims. Children diagnosed with PO-disruptive, depressive, and/or anxiety disorders were at least 6 times as likely as children without PO-psychiatric disorders to become aggressive-victims during elementary school after covarying for other key risk factors. Conclusions Findings suggested that PO-psychiatric disorders differentiated preschool and school-age children’s roles in relational aggression based on teacher-report. Recommendations for future research and preventative intervention aimed at minimizing the development of relational aggression in early childhood by identifying and targeting PO-psychiatric disorders are made. PMID:22917202

  9. Parental and Child Characteristics Related to Early-Onset Disordered Eating

    DEFF Research Database (Denmark)

    Larsen, Pernille Stemann; Strandberg-Larsen, Katrine; Micali, Nadia

    2015-01-01

    characteristics related to early-onset disordered eating. Systematic searches were conducted in PubMED/MEDLINE, EMBASE, and PsycInfo using the following search terms: eating disorder, disordered eating, problem eating, anorexia nervosa, bulimia nervosa, binge eating, child, preadolescent, and early onset. Studies...

  10. A vantage from space can detect earlier drought onset: an approach using relative humidity.

    Science.gov (United States)

    Farahmand, Alireza; AghaKouchak, Amir; Teixeira, Joao

    2015-02-25

    Each year, droughts cause significant economic and agricultural losses across the world. The early warning and onset detection of drought is of particular importance for effective agriculture and water resource management. Previous studies show that the Standard Precipitation Index (SPI), a measure of precipitation deficit, detects drought onset earlier than other indicators. Here we show that satellite-based near surface air relative humidity data can further improve drought onset detection and early warning. This paper introduces the Standardized Relative Humidity Index (SRHI) based on the NASA Atmospheric Infrared Sounder (AIRS) observations. The results indicate that the SRHI typically detects the drought onset earlier than the SPI. While the AIRS mission was not originally designed for drought monitoring, we show that its relative humidity data offers a new and unique avenue for drought monitoring and early warning. We conclude that the early warning aspects of SRHI may have merit for integration into current drought monitoring systems.

  11. Onset of impaired sleep as a predictor of change in health-related behaviours

    DEFF Research Database (Denmark)

    Clark, Alice Jessie; Salo, Paula; Lange, Theis

    2015-01-01

    used data from 37 508 adults from the longitudinal Finnish Public Sector Study. In analysis of 59 152 person-observations on duration and quality of sleep and health-related behaviours (alcohol consumption, smoking, physical activity and weight control), data were treated as a series of non......BACKGROUND: Changes in health-related behaviour may be a key mechanism linking impaired sleep to poor health, but evidence on this is limited. In this study, we analysed observational data to determine whether onset of impaired sleep is followed by changes in health-related behaviours. METHODS: We......-randomized pseudo-trials with strict predefined criteria for data inclusion and temporality. RESULTS: Smokers who experienced onset of short sleep were less likely to quit smoking than those with persistent normal sleep [odds ratio (OR) = 0.78, 95% confidence interval (CI): 0.64-0.97]. Onset of short sleep also...

  12. The impact of vocal hyperfunction on relative fundamental frequency during voicing offset and onset.

    Science.gov (United States)

    Stepp, Cara E; Hillman, Robert E; Heaton, James T

    2010-10-01

    This study tested the hypothesis that individuals with vocal hyperfunction would show decreases in relative fundamental frequency (RFF) surrounding a voiceless consonant. This retrospective study of 2 clinical databases used speech samples from 15 control participants and women with hyperfunction-related voice disorders: 82 prior to treatment (muscle tension dysphonia, n=22; vocal fold nodules, n=30; vocal fold polyps, N=30) and 18 before and after surgical removal of vocal fold nodules or polyps. Acoustic samples were analyzed with respect to the RFF at the offset and onset of voicing surrounding a voiceless consonant. Individuals with vocal hyperfunction in a large clinical sample showed significant lowering of offset and onset RFF compared with controls. Voicing offset and onset RFFs were not significantly changed by the removal of vocal fold lesions in the surgical group. Altered offset and onset RFF in patients with hyperfunction-related voice disorders can be interpreted as a by-product of heightened levels of laryngeal muscle tension. Measurement of RFF during voice offset and onset has potential for use as a simple, noninvasive measure of vocal hyperfunction.

  13. Evidence for apolipoprotein E {epsilon}4 association in early-onset Alzheimer`s patients with late-onset relatives

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Tur, J.; Delacourte, A.; Chartier-Harlin, M.C. [INSERM, Rouen (France)] [and others

    1995-12-18

    Recently several reports have extended the apolipoprotein E (APOE) {epsilon}4 association found in late-onset Alzheimer`s disease (LOAD) patients to early-onset (EO) AD patients. We have studied this question in a large population of 119 EOAD patients (onset {<=}60 years) in which family history was carefully assessed and in 109 controls. We show that the APOE {epsilon}A allele frequency is increased only in the subset of patients who belong to families where LOAD secondary cases are present. Our sampling scheme permits us to demonstrate that, for an individual, bearing at least one {epsilon}4 allele increases both the risk of AD before age 60 and the probability of belonging to a family with late-onset affected subjects. Our results suggest that a subset of EOAD cases shares a common determinism with LOAD cases. 19 refs., 3 tabs.

  14. Predicting Indian Summer Monsoon onset through variations of surface air temperature and relative humidity

    Science.gov (United States)

    Stolbova, Veronika; Surovyatkina, Elena; Kurths, Jurgen

    2015-04-01

    Indian Summer Monsoon (ISM) rainfall has an enormous effect on Indian agriculture, economy, and, as a consequence, life and prosperity of more than one billion people. Variability of the monsoonal rainfall and its onset have a huge influence on food production, agricultural planning and GDP of the country, which on 22% is determined by agriculture. Consequently, successful forecasting of the ISM onset is a big challenge and large efforts are being put into it. Here, we propose a novel approach for predictability of the ISM onset, based on critical transition theory. The ISM onset is defined as an abrupt transition from sporadious rainfall to spatially organized and temporally sustained rainfall. Taking this into account, we consider the ISM onset as is a critical transition from pre-monsoon to monsoon, which take place in time and also in space. It allows us to suggest that before the onset of ISM on the Indian subcontinent should be areas of critical behavior where indicators of the critical transitions can be detected through an analysis of observational data. First, we identify areas with such critical behavior. Second, we use detected areas as reference points for observation locations for the ISM onset prediction. Third, we derive a precursor for the ISM onset based on the analysis of surface air temperature and relative humidity variations in these reference points. Finally, we demonstrate the performance of this precursor on two observational data sets. The proposed approach allows to determine ISM onset in advance in 67% of all considered years. Our proposed approach is less effective during the anomalous years, which are associated with weak/strong monsoons, e.g. El-Nino, La-Nina or positive Indian Ocean Dipole events. The ISM onset is predicted for 23 out of 27 normal monsoon years (85%) during the past 6 decades. In the anomalous years, we show that time series analysis in both areas during the pre-monsoon period reveals indicators whether the

  15. Unmet needs and health-related quality of life in young-onset dementia

    NARCIS (Netherlands)

    Bakker, C.; Vugt, M.E. de; Vliet, D. van; Verhey, F.; Pijnenburg, Y.A.; Vernooij-Dassen, M.J.; Koopmans, R.T.

    2014-01-01

    OBJECTIVES: Young-onset dementia (YOD) causes specific challenges and issues that are likely to affect health-related quality of life (HRQOL). This study explored patient and caregiver HRQOL and its association with unmet needs in YOD. METHODS: A cross-sectional design was used to study 215 communit

  16. A note on Arabian Sea warm pool and its possible relation with monsoon onset over Kerala

    Digital Repository Service at National Institute of Oceanography (India)

    Chacko, K.V.; HareeshKumar, P.V.; RameshKumar, M.R.; Mathew, B.; Bannur, V.M.

    The possible relation of the Arabian Sea Warm Pool (ASWP) with monsoon onset over Kerala is studied by utilizing the TRMM Microwave Imager data during the period 2007-2011 (5 years). The ASWP is a part of the Indian Ocean warm pool and forms...

  17. Cumalative Distribution Functions for the Relative Humidity Thresholds for the Onset of Carbon Steel Corrosion

    Energy Technology Data Exchange (ETDEWEB)

    K.G. Mon

    1998-05-13

    The purpose of this calculation is to process the cumulative distribution functions (CDFs) characterizing the relative humidity (RH) thresholds for the onset of carbon steel corrosion provided by expert elicitation and minimize the set of values to 200 points for use in WAPDEG.

  18. Cytokines in relation to autoantibodies before onset of symptoms for systemic lupus erythematosus.

    Science.gov (United States)

    Eriksson, C; Rantapää-Dahlqvist, S

    2014-06-01

    A number of cytokines and chemokines were analysed and related to autoantibodies in blood samples pre-dating the onset of symptoms of systemic lupus erythematosus. Thirty-five patients with systemic lupus erythematosus (American College of Rheumatology criteria) were identified as having donated blood samples, prior to symptom onset, to the Biobank of northern Sweden. Altogether, 140 age- and sex-matched controls were also identified. The concentrations of interferon-α, interleukin-4, interleukin-9, interleukin-10, interferon inducible protein-10 and monocyte chemotactic protein-1 were analysed using multiplex technology and related to autoantibodies (ANA, ENA, anti-dsDNA and anti-histone antibodies) analysed from the same blood sample. The interferon-γ inducible protein-10 levels were higher in the pre-symptomatic individuals than in controls (p systemic lupus erythematosus. An increased concentration of interferon-γ inducible protein-10 pre-dated the onset of systemic lupus erythematosus and was related to autoantibodies before the onset of disease. The levels of interferon-γ inducible protein-10 and interferon-α were correlated. These findings support the proposal that the interferon system is important early in the pathogenesis of systemic lupus erythematosus and autoantibody formation. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  19. Pancuronium, gallamine, and d-tubocurarine compared: is speed of onset inversely related to drug potency?

    Science.gov (United States)

    Kopman, A F

    1989-06-01

    The relative potency and speed of onset of action of pancuronium, gallamine, and d-tubocurarine was studied in 55 adult female patients receiving nitrous oxide/oxygen-narcotic anesthesia. The integrated electromyogram of the adductor pollicis muscle was monitored using a cumulative dose-response technique; train-of-four stimuli were administered at 0.05 Hz. The measured ED95 values for pancuronium and gallamine were 0.069 and 2.38 mg/kg, respectively. In three separate groups, pancuronium 0.07 mg/kg, gallamine 2.4 mg/kg, or d-tubocurarine 0.45 mg/kg were given as a single bolus and the speed of onset and time to maximum effect determined. Peak twitch depression was essentially identical in all groups (92.7 +/- 1.4 [SE] vs. 93.3 +/- 1.1 vs. 93.7 +/- 1.1%, respectively). The rate of onset of neuromuscular blockade in these three groups was, however, quite different. After administration of pancuronium (n = 10) the times to 5%, 20%, 50%, and 80% twitch depression were 68 +/- 5, 97 +/- 6, 141 +/- 8, and 222 +/- 18 s. The comparable times following gallamine (n = 10) were 29 +/- 2, 42 +/- 3, 66 +/- 5, and 136 +/- 14 s; d-tubocurarine (n = 10) was intermediate in speed with onset times of 40 +/- 4, 63 +/- 6, 99 +/- 11, and 178 +/- 25 s. It appears that the onset times of different nondepolarizing blocking agents (even when given in equipotent doses) may vary by clinically appreciable amounts. The results of this study support the hypothesis that nondepolarizing neuromuscular blocking agents of low potency may have a more rapid onset of action than that seen with agents of high potency.

  20. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease.

    Science.gov (United States)

    Silverman, E K; Weiss, S T; Drazen, J M; Chapman, H A; Carey, V; Campbell, E J; Denish, P; Silverman, R A; Celedon, J C; Reilly, J J; Ginns, L C; Speizer, F E

    2000-12-01

    Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than women, which has been attributed to the historically higher rates of cigarette smoking in males. However, the increased rates of cigarette smoking in females within the last several decades have been associated with steadily increasing rates of COPD in women. As part of a study of the genetics of severe, early-onset COPD, we assembled a group of 84 probands with severe, early-onset COPD (without severe alpha(1)-antitrypsin deficiency) and 348 of their first-degree relatives. We found a markedly elevated prevalence (71.4%) of females among the early-onset COPD probands. Among the entire group of first-degree relatives of early-onset COPD probands, univariate analysis demonstrated similar spirometric values and bronchodilator responsiveness in males and females; however, among current or ex-smokers, female first-degree relatives had significantly lower FEV(1)/ FVC (81.4 +/- 17.2% in females versus 87.0 +/- 12.9% in males, p = 0.009) and significantly greater bronchodilator responsiveness (expressed as percentage of baseline FEV(1)) (7.7 +/- 9.4% pred in females versus 4.1 +/- 6.4% pred in males, p = 0.002). Female smoking first-degree relatives were significantly more likely to demonstrate profound reductions in FEV(1) (< 40% pred) than male smoking first-degree relatives (p = 0. 03). Multivariate analysis, performed with generalized estimating equations, demonstrated that current or ex-smoking female first-degree relatives had significantly greater risk of FEV(1) < 80% pred (OR 1.91, 95% CI 1.03- 3.54), FEV(1) < 40% pred (OR 3.56, 95% CI 1.08-11.71), and bronchodilator response greater than 10% of baseline FEV(1) (OR 4.74, 95% CI 1.91-11.75). These results suggest that women may be more susceptible to the development of severe COPD.

  1. Decadal Variation of the Number of El Nino Onsets and El Nino-Related Months and Estimating the Likelihood of El Nino Onset in a Warming World

    Science.gov (United States)

    Wilson, Robert M.

    2009-01-01

    Examination of the decadal variation of the number of El Nino onsets and El Nino-related months for the interval 1950-2008 clearly shows that the variation is better explained as one expressing normal fluctuation and not one related to global warming. Comparison of the recurrence periods for El Nino onsets against event durations for moderate/strong El Nino events results in a statistically important relationship that allows for the possible prediction of the onset for the next anticipated El Nino event. Because the last known El Nino was a moderate event of short duration (6 months), having onset in August 2006, unless it is a statistical outlier, one expects the next onset of El Nino probably in the latter half of 2009, with peak following in November 2009-January 2010. If true, then initial early extended forecasts of frequencies of tropical cyclones for the 2009 North Atlantic basin hurricane season probably should be revised slightly downward from near average-to-above average numbers to near average-to-below average numbers of tropical cyclones in 2009, especially as compared to averages since 1995, the beginning of the current high-activity interval for tropical cyclone activity.

  2. Cortical thickness development of human primary visual cortex related to the age of blindness onset.

    Science.gov (United States)

    Li, Qiaojun; Song, Ming; Xu, Jiayuan; Qin, Wen; Yu, Chunshui; Jiang, Tianzi

    2016-07-28

    Blindness primarily induces structural alteration in the primary visual cortex (V1). Some studies have found that the early blind subjects had a thicker V1 compared to sighted controls, whereas late blind subjects showed no significant differences in the V1. This implies that the age of blindness onset may exert significant effects on the development of cortical thickness of the V1. However, no previous research used a trajectory of the age of blindness onset-related changes to investigate these effects. Here we explored this issue by mapping the cortical thickness trajectory of the V1 against the age of blindness onset using data from 99 blind individuals whose age of blindness onset ranged from birth to 34 years. We found that the cortical thickness of the V1 could be fitted well with a quadratic curve in both the left (F = 11.59, P = 3 × 10(-5)) and right hemispheres (F = 6.54, P = 2 × 10(-3)). Specifically, the cortical thickness of the V1 thinned rapidly during childhood and adolescence and did not change significantly thereafter. This trend was not observed in the primary auditory cortex (A1), primary motor cortex (M1), or primary somatosensory cortex (S1). These results provide evidence that an onset of blindness before adulthood significantly affects the cortical thickness of the V1 and suggest a critical period for cortical development of the human V1.

  3. Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions.

    Science.gov (United States)

    Müller, Werner E G; Schröder, Heinz C; Tolba, Emad; Diehl-Seifert, Bärbel; Wang, Xiaohong

    2016-01-01

    Inorganic polyphosphate (polyP) is a physiological energy-rich polymer with multiple phosphoric anhydride bonds. In cells such as bone-forming osteoblasts, glycolysis is the main pathway generating metabolic energy in the form of ATP. In the present study, we show that, under hypoxic culture conditions, the growth/viability of osteoblast-like SaOS-2 cells is not impaired. The addition of polyP to those cells, administered as amorphous calcium polyP nanoparticles (aCa-polyP-NP; approximate size 100 nm), significantly increased the proliferation of the cells. In the presence of polyP, the cells produce significant levels of lactate, the end product of anaerobic glycolysis. Under those conditions, an eight-fold increase in the steady-state level of the membrane-associated carbonic anhydrase IX is found, as well as a six-fold induction of the hypoxia-inducible factor 1. Consequently, biomineral formation onto the SaOS-2 cells decreases under low oxygen tension. If the polyP nanoparticles are added to the cells, the degree of mineralization is enhanced. These changes had been measured also in human mesenchymal stem cells. The assumption that the bicarbonate, generated by the carbonic anhydrase in the presence of polyP under low oxygen, is deposited as a constituent of the bioseeds formed during initial hydroxyapatite formation is corroborated by the identification of carbon besides of calcium, oxygen and phosphorus in the initial biomineral deposit onto the cells using the sensitive technology of high-resolution energy dispersive spectrometry mapping. Based on these data, we conclude that polyP is required for the supply of metabolic energy during bone mineral formation under physiological, hypoxic conditions, acting as a 'metabolic fuel' for the cells to grow.

  4. Phenotype-Genotype Analysis of Chinese Patients with Early-Onset LMNA-Related Muscular Dystrophy.

    Directory of Open Access Journals (Sweden)

    Dandan Tan

    Full Text Available This study aimed to analyze the correlation between the phenotype and genotype of Chinese patients with early-onset lamin A (LMNA-related muscular dystrophy (MD. The clinical and myopathological data of 21 Chinese pediatric patients with early-onset LMNA-related MD were collected and analyzed. LMNA gene mutation analysis was performed by direct sequencing of genomic DNA. Sublocalization of wild-type and mutant proteins were observed by immunofluorescence using cultured fibroblasts and human embryonic kidney 293 (HEK 293 cell. Seven patients were diagnosed with Emery-Dreifuss muscular dystrophy (EDMD and 14 were diagnosed with LMNA-associated congenital muscular dystrophy (L-CMD. Four biopsy specimens from the L-CMD cases exhibited inflammatory changes. Abnormal nuclear morphology was observed with both transmission electron microscopy and lamin A/C staining. We identified 10 novel and nine known LMNA gene mutations in the 21 patients. Some mutations (c.91G>A, c.94_96delAAG, c.116A>G, c.745C>T, c.746G>A, and c.1580G>C were well correlated with EDMD or L-CMD. LMNA-related MD has a common symptom triad of muscle weakness, joint contractures, and cardiac involvement, but the severity of symptoms and disease progression differ greatly. Inflammatory change in biopsied muscle is a characteristic of early-stage L-CMD. Phenotype-genotype analysis determines that some mutations are well correlated with LMNA-related MD.

  5. Water SA

    African Journals Online (AJOL)

    Journal Home > Vol 43, No 2 (2017) ... WaterSA publishes refereed, original work in all branches of water science, technology and engineering. ... Water SA is the WRC's accredited scientific journal which contains original research articles ... via linearized calibration method in the upstream of Huaihe River Basin, China ...

  6. [Psychosocial and socioeconomic factors related to insomnia and menopause: Pró-Saúde Study].

    Science.gov (United States)

    Robaina, Jaqueline Rodrigues; Lopes, Claudia S; Rotenberg, Lúcia; Faerstein, Eduardo

    2015-03-01

    This study evaluated the association between insomnia and menopausal status and the influence of socioeconomic and psychosocial variables on this association in a cross-sectional analysis of 2,190 university employees (the Pró-Saúde Study). A self-administered questionnaire was used, covering menopausal status, complaints of insomnia, common mental disorders, stressful life events, social support, and socioeconomic variables. Odds ratios were calculated using logistic regression with a polytomous outcome. After adjusting for potential socio-demographic confounders, women who had entered menopause more than 60 months previously were more likely to report complaints with sleep (OR 1.53-1.86) as compared to women in menopause for less than 60 months. After adjusting for psychosocial variables, in the first group the ORs decreased to 1.53 (95%CI: 0.92-2.52) for difficulty initiating sleep, 1.81 (95%CI: 1.09-2.98) for difficulty maintaining sleep, and 1.71 (95%CI: 1.08-2.73) for general complaints of insomnia. Psychosocial factors can mediate the manifestation of insomnia among menopausal women.

  7. Relações sociais e autopercepção da saúde: projeto envelhecimento e saúde Social relations and self- rated health: the ageing and health project

    Directory of Open Access Journals (Sweden)

    Ana Paula Nogueira Nunes

    2012-06-01

    Full Text Available OBJETIVO: Investigar a associação entre as relações sociais e a autopercepção da saúde em idosos. MÉTODOS: Estudo transversal de amostra representativa de idosos cobertos pelo Programa de Saúde da Família e residentes em uma área de alta vulnerabilidade para a saúde em Belo Horizonte, MG. As informações foram obtidas por meio de entrevista estruturada. Idosos que relataram autopercepção ruim ou muito ruim da saúde foram comparados aos demais e os fatores associados foram determinados por meio de regressão logística múltipla. RESULTADOS: 363 dos 371 idosos elegíveis participaram do estudo. A autopercepção ruim da saúde foi relatada por 17,1% dos idosos e foi positivamente associada com o número de doenças crônicas e o grau de dificuldade para realizar as atividades de vida diária, apresentando um gradiente dose resposta. Idosos com auto-avaliação negativa dos relacionamentos pessoais e que não podiam contar com alguém caso ficassem acamados tiveram mais chance de autoperceber sua saúde como ruim. Trabalhar foi associado negativamente com a autopercepção ruim da saúde. CONCLUSÃO: Os resultados encontrados corroboram a estrutura multidimensional da autopercepção da saúde englobando fatores sociodemográficos, aspectos relacionados à saúde e às relações sociais e reforçam o papel dessas últimas sobre a saúde.OBJECTIVE: To investigate the association between social relationships and self-perceived health in the elderly. METHODS: cross-sectional study of a representative sample of elderly individuals covered by the Family Health Program and residents in an area of high health vulnerability in Belo Horizonte, MG. Information was obtained through structured interviews. Factors associated with poor or very poor self-perceived health were identified by multiple logistic regression analysis. RESULTS: 363 out of 371 eligible elderly participated; 17.1% of elderly self-perceived their health as poor. There was

  8. Eqüidade em saúde nos relatórios das conferências nacionais de saúde pós-Constituição Federal brasileira de 1988

    Directory of Open Access Journals (Sweden)

    Marcelo Cardoso Pinheiro

    2005-04-01

    Full Text Available A partir de um posicionamento sobre o conceito de eqüidade e sua aplicação no campo da saúde pública, com base em revisão de literatura, o objetivo deste artigo é discutir o significado atribuído ao uso do termo eqüidade ou variações deste termo nos relatórios das 9ª, 10ª e 11ª Conferências Nacionais de Saúde. Utilizou-se a metodologia qualitativa e a técnica análise de conteúdo para analisar a abordagem da questão da eqüidade nos dois produtos que as Conferências se propõem a formular: a apresentação de um quadro da saúde no país e diretrizes para as políticas públicas de saúde. Verificou-se que houve pouco avanço em relação ao entendimento do tema eqüidade em saúde, com predomínio de um discurso com sentido vago ou excessivamente amplo. As proposições apresentadas foram caracterizadas também como gerais e inespecíficas, uma vez que na maior parte das vezes, não foram definidos grupos sociais a que as propostas se dirigiam ou o problema a ser enfrentado.

  9. Eqüidade em saúde nos relatórios das conferências nacionais de saúde pós-Constitui��ão Federal brasileira de 1988

    Directory of Open Access Journals (Sweden)

    Pinheiro Marcelo Cardoso

    2005-01-01

    Full Text Available A partir de um posicionamento sobre o conceito de eqüidade e sua aplicação no campo da saúde pública, com base em revisão de literatura, o objetivo deste artigo é discutir o significado atribuído ao uso do termo eqüidade ou variações deste termo nos relatórios das 9feminine, 10feminine e 11feminine Conferências Nacionais de Saúde. Utilizou-se a metodologia qualitativa e a técnica análise de conteúdo para analisar a abordagem da questão da eqüidade nos dois produtos que as Conferências se propõem a formular: a apresentação de um quadro da saúde no país e diretrizes para as políticas públicas de saúde. Verificou-se que houve pouco avanço em relação ao entendimento do tema eqüidade em saúde, com predomínio de um discurso com sentido vago ou excessivamente amplo. As proposições apresentadas foram caracterizadas também como gerais e inespecíficas, uma vez que na maior parte das vezes, não foram definidos grupos sociais a que as propostas se dirigiam ou o problema a ser enfrentado.

  10. Demographic features and premorbid personality disorder traits in relation to age of onset and sex in paranoid schizophrenia.

    Science.gov (United States)

    Skokou, Maria; Gourzis, Philippos

    2014-03-30

    Personality disorders in the premorbid period of schizophrenia and particularly in relation to age of onset and sex, seem to be a rather under-researched area. In the present study, 88 patients with paranoid schizophrenia were examined, regarding demographic characteristics and premorbid personality disorder traits, in order to investigate for differences in the premorbid period of the disease, in relation to age of onset and sex. Age cutoff points were set at paranoid schizophrenia.

  11. Immune-related late-onset hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantation

    Institute of Scientific and Technical Information of China (English)

    HUANG Xiao-jun; LIU Dai-hong; XU Lan-ping; ZHANG Hong-yu; LIU Kai-yan

    2008-01-01

    Background The pathophysiology of late-onset hemorrhagic cystitis (LOHC) is currently not well understood.The aim of this study was to analyze the ailoimmune aetiology in the pathogenesis of LOHC post allogeneic hematopoietic stem cell transplantation (HSCT).Methods A retrospective study was performed on the medical records of 11 patients with immune-related LOHC post allogeneic HSCT. The clinical characteristics, therapy, and outcomes of these patients were analyzed.Results The median time of onset was 42 days after HSCT (range 16-150 days) and the median duration of HC was 43 days (range 29-47 days).All patients presented with prolonged HC for more than 35 days. Nine patients with evidence of cytomegalovirus (CMV) reactivation did not respond to anti-viral therapy even with CMV clearance in the urine post-therapy.Eleven patients with refractory HC received a low dose of corticosteroids and all patients went into complete remission.Conclusion Our data suggest that alloimmune injury is involved in the pathogenesis of HC in at least some patients and that specific therapy might improve the clinical outcome of hemorrhagic cystitis.

  12. Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

    OpenAIRE

    Modestino, Edward J.; Amenechi, Chioma; Reinhofer, AnnaMarie; O'Toole, Patrick

    2016-01-01

    Abstract Background Parkinson's disease (PD) usually emerges with a unilateral side‐of‐onset (left‐onset: LOPD; right‐onset: ROPD; Marinus & van Hilten, 2015) due to an asymmetrical degeneration of striatal dopaminergic neurons (Donnemiller et al., Brain, 135, 2012, 3348). This has led to a body of research exploring the cognitive, neuropsychological, and clinical differences between LOPD and ROPD (e.g., Verreyt et al., Neuropsychology Review, 21, 2011, 405). Methods Thirty ROPD and 14 LOPD c...

  13. Individual traffic-related air pollution and new onset adult asthma:A GIS-based pilot study

    DEFF Research Database (Denmark)

    Lysbeck Hansen, Carl; Jensen, Steen Solvang; Baelum, Jesper

    The background for the project is that traffic-related air pollution may provoke the onset of asthma. The objective of this pilot study is to investigate the relation between asthma and wheeze debut and individually estimated exposure to traffic-related air pollutants with a validated exposure...... demonstrated. A tendency towards higher levels of nitrogen oxides exposure during the year prior to debut was seen in wheeze cases. Substantial problems in determining time of onset were encountered. This pilot study successfully demonstrated the feasibility of using AirGIS to study correlations between...... individual traffic-related air pollution exposure and new onset asthma and wheeze. It is recommended that the analytic methods developed in this pilot study are used in a larger prospective cohort to investigate individual traffic-related air pollutants as a risk factor for the development of new asthma...

  14. Determination of summer monsoon onset and its related large-scale circulation characteristics over Pakistan

    Science.gov (United States)

    Latif, M.; Syed, F. S.

    2016-08-01

    The onset of summer monsoon over the Core Monsoon Region of Pakistan (CMRP) has been investigated in this study using observational daily rainfall and Precipitable Water (PW) data sets. An objective criterion is proposed to define monsoon onset dates by employing Precipitation Index and Normalized Precipitable Water Index techniques. The climatological mean summer monsoon onset dates over CMRP based on daily rainfall data sets are observed to be 1 July and 30 June in the station and gridded data sets, respectively. Whereas the daily PW-based climatological mean onset date is 30 June. The year-wise onset dates determined through station and gridded rainfall data sets are very similar but these dates differ in case of PW-based onsets. The evolution of large-scale circulation anomalies and thermodynamic structure leading monsoon onset over Pakistan shows that a strong positive temperature and geopotential height anomalies appear over the northwestern part of the core region in the upper atmosphere. This warm geopotential height anomaly gets strengthen as the monsoon onset approaches. The temperature anomalies are barotropic whereas the geopotential height anomalies are baroclinic with the presence of low level anticyclone over the Tibetan Plateau. A moisture convergence zone along the foothill of Himalayas and low level moisture convergence zone over the north Arabian Sea set the stage for the moisture carrying monsoon winds to blow inland towards CMRP. The moisture is mainly supplied from the Arabian Sea, as the low pressure system approaches CMRP from the Bay of Bengal.

  15. Responses to Tobacco Smoking-Related Health Messages in Young People With Recent-Onset Schizophrenia.

    Science.gov (United States)

    Coletti, Daniel J; Brunette, Mary; John, Majnu; Kane, John M; Malhotra, Anil K; Robinson, Delbert G

    2015-11-01

    Virtually no research has examined the responses of youth with recent-onset psychosis (ROP) to smoking-related health warnings. We examined predictors of response and tested hypotheses that participants with ROP would (a) assess warnings as less effective than a healthy comparison (HC) group, and (b) assess video warnings as more effective than pictures. ROP participants (n = 69) had smoking knowledge. We assessed response at baseline and at 4-week follow-up. ROP participants were more likely than HC to smoke tobacco (49.3% vs 10.1%) and had lower levels of health literacy and smoking-related knowledge. Cannabis was used by 46.4% of ROP participants. Effectiveness ratings were high for both picture and video warnings with no differences between media. ROP participants compared to HC and nonsmokers compared to smokers were more likely to perceive warnings as effective. Effectiveness was associated with negative affect and greater emotional arousal. We assessed 33 smokers at follow-up; 5 (15%) identified as nonsmokers, 15 (45%) made a quit attempt, and 16 (49%) reported that the warnings influenced their smoking. Results indicate that young people with psychotic disorders respond favorably to health warnings. Effective messages depict health consequences clearly, elicit negative emotions, and may impact smoking behavior. Future research is needed to understand the effects of mode of presentation and message comprehension on smoking behavior.

  16. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis.

    Science.gov (United States)

    Silverman, E K; Chapman, H A; Drazen, J M; Weiss, S T; Rosner, B; Campbell, E J; O'DONNELL, W J; Reilly, J J; Ginns, L; Mentzer, S; Wain, J; Speizer, F E

    1998-06-01

    Severe alpha-1-antitrypsin deficiency is the only proven genetic risk factor for chronic obstructive pulmonary disease (COPD). We have assembled a cohort of 44 probands with severe, early-onset COPD, who do not have severe alpha-1-antitrypsin deficiency. A surprisingly high prevalence of females (79.6%) was found. Assessment of the risk to relatives of these early-onset COPD probands for airflow obstruction and chronic bronchitis was performed to determine whether significant familial aggregation for COPD, independent of alpha-1-antitrypsin deficiency, could be demonstrated. First- degree relatives of early-onset COPD probands had significantly lower FEV1 and FEV1/FVC values than control subjects (p < 0.01), despite similar pack-years of smoking. Reduced spirometric values in first-degree relatives of early-onset COPD probands were found only in current or ex-cigarette smokers. The mean FEV1 in current or ex-smoking first-degree relatives was 76.1 +/- 20.9% predicted compared to 89.2 +/- 14.4% predicted in current or ex-smoking control subjects (p < 0.01); in lifelong nonsmokers, the mean FEV1 was 93.4% predicted for both control subjects and first-degree relatives of early-onset COPD probands. Generalized estimating equations, adjusting for age and pack-years of smoking, demonstrated increased odds of reduced FEV1 and chronic bronchitis in current or ex-smoking first-degree relatives of early-onset COPD probands. Using a new method to estimate relative risk from relative odds, we estimate that the relative risks for FEV1 below 60%, FEV1 below 80%, and chronic bronchitis are each approximately three in current or ex-smoking first-degree relatives of early-onset COPD probands. The increased risk to relatives of early-onset COPD probands for reduced FEV1 and chronic bronchitis, limited to current or ex-smokers, suggests genetic risk factor(s) for COPD that are expressed in response to cigarette smoking.

  17. Practices related to late-onset sepsis in very low-birth weight preterm infants

    Directory of Open Access Journals (Sweden)

    Maria Regina Bentlin

    2015-04-01

    Full Text Available OBJECTIVE: To understand the practices related to late-onset sepsis (LOS in the centers of the Brazilian Neonatal Research Network, and to propose strategies to reduce the incidence of LOS. METHODS: This was a cross-sectional descriptive multicenter study approved by the Ethics Committee. Three questionnaires regarding hand hygiene, vascular catheters, and diagnosis/treatment of LOS were sent to the coordinator of each center. The center with the lowest incidence of LOS was compared with the others. RESULTS: All 16 centers answered the questionnaires. Regarding hand hygiene, 87% use chlorhexidine or 70% alcohol; alcohol gel is used in 100%; 80% use bedside dispensers (50% had one dispenser for every two beds; practical training occurs in 100% and theoretical training in 70% of the centers, and 37% train once a year. Catheters: 94% have a protocol, and 75% have a line insertion team. Diagnosis/treatment: complete blood count and blood culture are used in 100%, PCR in 87%, hematological scores in 75%; oxacillin and aminoglycosides is the empirical therapy in 50% of centers. Characteristics of the center with lowest incidence of LOS: stricter hand hygiene; catheter insertion and maintenance groups; use of blood culture, PCR, and hematological score for diagnosis; empirical therapy with oxacillin and aminoglycoside. CONCLUSION: The knowledge of the practices of each center allowed for the identification of aspects to be improved as a strategy to reduce LOS, including: alcohol gel use, hand hygiene training, implementation of catheter teams, and wise use of antibiotic therapy.

  18. O sofrimento psíquico de agentes comunitários de saúde e suas relações com o trabalho The psychological distress of community health agents and its relations to working conditions

    Directory of Open Access Journals (Sweden)

    Alcindo José Rosa

    2012-03-01

    Full Text Available O estudo tem a finalidade de analisar aspectos que, quando presentes nas condições e relações de trabalho de Agentes Comunitários de Saúde (ACS, podem relacionar-se ao desencadeamento de sofrimento psíquico nestes profissionais e, consequentemente, impedir que tenham uma postura profissional ativa e mediadora, tanto para a garantia do direito à saúde quanto para a operacionalização dos serviços de saúde. Para o delineamento conceitual e caracterização do fenômeno estudado, recorreu-se ao corpus de conhecimentos produzidos por Dejours, que ofereceu, nas últimas décadas, importantes contribuições para a compreensão da Psicodinâmica do Trabalho e suas consequências. A pesquisa foi realizada durante uma intervenção em unidade de saúde da Estratégia Saúde da Família do município de Rondonópolis (MT; para a coleta de dados foram realizados os seguintes procedimentos: grupos de conversa e entrevistas abertas com agentes comunitários de saúde, observação do trabalho que realizavam e entrevistas abertas com a população usuária das unidades. A apreciação dos resultados partiu do registro cursivo e análise dos discursos captados durante as atividades e foi feita por meio de categorias, que foram analisadas. Considerou-se que há situações que caracterizam a sobrecarga de trabalho do ACS em vários âmbitos. Duas consequências foram apontadas, uma relacionada com a perda das especificidades da profissão, o que parece levar ao desvirtuamento das atribuições profissionais, e a outra associada à insalubridade das condições e relações de trabalho. Ambas parecem estar relacionadas com a produção de sofrimento psíquico nos agentes comunitários de saúde, o que pode ser minimizado com maior empoderamento destes profissionais.This work intends to analyse some aspects that, when they are present in community health agents' working conditions and relationships, can be linked to the onset of psychological

  19. 75 FR 6397 - AMC USA, Inc. v. International First Service S.A. a/k/a IFS S.A, its Agents, Affiliated, Related...

    Science.gov (United States)

    2010-02-09

    ... Complainant in order to gain an unfair business advantage and/or in order to provide ocean transportation for... of the Shipping Act, Complainant has had ``injury involving customer relations, its reputation in the...

  20. Individual traffic-related air pollution and new onset adult asthma:A GIS-based pilot study

    DEFF Research Database (Denmark)

    Lysbeck Hansen, Carl; Jensen, Steen Solvang; Baelum, Jesper

    individual traffic-related air pollution exposure and new onset asthma and wheeze. It is recommended that the analytic methods developed in this pilot study are used in a larger prospective cohort to investigate individual traffic-related air pollutants as a risk factor for the development of new asthma......The background for the project is that traffic-related air pollution may provoke the onset of asthma. The objective of this pilot study is to investigate the relation between asthma and wheeze debut and individually estimated exposure to traffic-related air pollutants with a validated exposure...... successfully identified for all study participants (N=33). Using AirGIS traffic-related air pollutant levels from both urban background and street level were estimated for the 10 year study period on an hourly basis. Individual levels of air pollutants in the years preceding debut of asthma or wheeze were...

  1. Association between age at onset of multiple sclerosis and vitamin D level-related factors

    DEFF Research Database (Denmark)

    Laursen, Julie Hejgaard; Søndergaard, Helle Bach; Sørensen, Per Soelberg

    2016-01-01

    OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset. METHODS: This cros....... No association was found between age at onset and any of the other SNPs or vitamin D-associated environmental factors. CONCLUSION: We demonstrate an independent effect by HLA-DRB1*1501, adolescent summer sun habits, and body mass index at the age of 20 on age at onset of MS.......OBJECTIVE: To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset. METHODS: This cross......, and the study was approved by the local ethics committee. RESULTS: Younger age at onset was significantly associated with low exposure to summer sun in adolescence, higher body mass index at 20 years of age, and the HLA-DRB1*1501 risk allele in both univariate analyses and in a multivariable regression analysis...

  2. Time of onset in haemodialysis access-induced distal ischaemia (HAIDI) is related to the access type.

    NARCIS (Netherlands)

    Scheltinga, M.R.M.; Hoek, F. van; Bruijninckx, C.M.

    2009-01-01

    BACKGROUND: A small portion of haemodialysis patients develop hand ischaemia (HAIDI, haemodialysis access-induced distal ischaemia) in the presence of an arteriovenous access (AVA). It is unknown if the time of onset of ischaemia is related to the type of AVA. This review aims to investigate if a re

  3. Whole Genome Comparison of Thermus sp. NMX2.A1 Reveals Principle Carbon Metabolism Differences with Closest Relation Thermus scotoductus SA-01

    Directory of Open Access Journals (Sweden)

    Walter J. Müller

    2016-09-01

    Full Text Available Genome sequencing of the yellow-pigmented, thermophilic bacterium Thermus sp. NMX2.A1 resulted in a 2.29 Mb draft genome that encodes for 2312 proteins. The genetic relationship between various strains from the genus Thermus was assessed based on phylogenomic analyses using a concatenated set of conserved proteins. The resulting phylogenetic tree illustrated that Thermus sp. NMX2 A.1 clusters together with Thermus scotoductus SA-01, despite being isolated from vastly different geographical locations. The close evolutionary relationship and metabolic parallels between the two strains has previously been recognized; however, neither strain’s genome data were available at that point in time. Genomic comparison of the Thermus sp. NMX2.A1 and T. scotoductus SA-01, as well as other closely related Thermus strains, revealed a high degree of synteny at both the genomic and proteomic level, with processes such as denitrification and natural cell competence appearing to be conserved. However, despite this high level of similarity, analysis revealed a complete, putative Calvin–Benson–Bassham (CBB cycle in NMX2.A1 that is absent in SA-01. Analysis of horizontally transferred gene islands provide evidence that NMX2 selected these genes due to pressure from its HCO3- rich environment, which is in stark contrast to that of the deep subsurface isolated SA-01.

  4. Practices related to late-onset sepsis in very low-birth weight preterm infants.

    Science.gov (United States)

    Bentlin, Maria Regina; Rugolo, Ligia M S S; Ferrari, Ligia S L

    2015-01-01

    To understand the practices related to late-onset sepsis (LOS) in the centers of the Brazilian Neonatal Research Network, and to propose strategies to reduce the incidence of LOS. This was a cross-sectional descriptive multicenter study approved by the Ethics Committee. Three questionnaires regarding hand hygiene, vascular catheters, and diagnosis/treatment of LOS were sent to the coordinator of each center. The center with the lowest incidence of LOS was compared with the others. All 16 centers answered the questionnaires. Regarding hand hygiene, 87% use chlorhexidine or 70% alcohol; alcohol gel is used in 100%; 80% use bedside dispensers (50% had one dispenser for every two beds); practical training occurs in 100% and theoretical training in 70% of the centers, and 37% train once a year. Catheters: 94% have a protocol, and 75% have a line insertion team. Diagnosis/treatment: complete blood count and blood culture are used in 100%, PCR in 87%, hematological scores in 75%; oxacillin and aminoglycosides is the empirical therapy in 50% of centers. Characteristics of the center with lowest incidence of LOS: stricter hand hygiene; catheter insertion and maintenance groups; use of blood culture, PCR, and hematological score for diagnosis; empirical therapy with oxacillin and aminoglycoside. The knowledge of the practices of each center allowed for the identification of aspects to be improved as a strategy to reduce LOS, including: alcohol gel use, hand hygiene training, implementation of catheter teams, and wise use of antibiotic therapy. Copyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  5. Community-onset healthcare-related urinary tract infections: comparison with community and hospital-acquired urinary tract infections.

    Science.gov (United States)

    Aguilar-Duran, Silvia; Horcajada, Juan P; Sorlí, Luisa; Montero, Milagro; Salvadó, Margarita; Grau, Santiago; Gómez, Julià; Knobel, Hernando

    2012-05-01

    To analyze the characteristics of infection, adequacy of empirical treatment and outcome of patients with community-onset healthcare-associated (HCA) urinary tract infections (UTI) and compare them with hospital (HA) and community-acquired (CA) UTI. Prospective observational cohort study performed at a university 600-bed hospital between July 2009 and February 2010. Patients with UTI requiring hospital admission were included. Epidemiological, clinical and outcome data were recorded. 251 patients were included. Patients with community-onset HCA UTI were older, had more co-morbidities and had received previous antimicrobial treatment more frequently than CA UTI (p = 0.02, p = 0.01 and p infections were more frequent in HCA than in CA UTI (p = 0.03 and p community-onset HCA and CA. Factors related to mortality were P. aeruginosa infection (OR 6.51; 95%CI: 1.01-41.73), diabetes mellitus (OR 22.66; 95%CI: 3.61-142.21), solid neoplasia (OR 22.48; 95%CI: 3.38-149.49) and age (OR 1.15; 95%CI 1.03-1.28). Epidemiological, clinical and microbiological features suggest that community-onset HCA UTI is different from CA and similar to HA UTI. However, in our series inadequate empirical antimicrobial therapy and mortality were not significantly higher in community-onset HCA than in CA UTI. Copyright © 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

  6. Early onset of cannabis use: Does personality modify the relation with changes in perceived parental involvement?

    NARCIS (Netherlands)

    Creemers, Hanneke E.; Buil, J. Marieke; van Lier, Pot A. C.; Keijsers, Loes; Meeus, W.H.J.; Koot, Hans M.; Huizink, Anja C.

    2015-01-01

    Background The present study examined (1) the association between changes in perceived parental control and support from age 13 to 15 and early onset of cannabis use (before age 16), and (2) whether personality modifies the association between a decline in perceived parental control and support and

  7. Time to onset of bisphosphonate-related osteonecrosis of the jaws

    DEFF Research Database (Denmark)

    Fung, Ppl; Bedogni, G; Bedogni, A

    2017-01-01

    OBJECTIVES: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to esti...

  8. Objective civil liability for work-related health damages Responsabilidade civil objetiva pelos danos à saúde do trabalhador

    Directory of Open Access Journals (Sweden)

    Juliane Caravieri Martins Gambá

    2007-11-01

    Full Text Available The environment, including that of work , is considered a basic right guaranteed by Magna Carta (article 7º, XXII, section 225, caption and article 200, VIII . The social value of work represents the pillars of Economic Order (article 170, CF and Social Order (article 193, CF, which offers full health and physical integrity protection to workers in their working environment. Thus, the question of work-related damages suffered by employees due to industrial accidents and occupational hazards must be analyzed within the work environment protection legal context , adopting the objective civil liability theory, by means of a teleologic logical-systematic interpretation of constitutional and infra-constitutional rules. This interpretation evidences the compatibility of the economic activity and the free initiative according to the Democratic State of Right, in order to build a more just and united society , thus reducing social inequalities.O meio ambiente, incluído o do trabalho, é considerado um direito fundamental, estando expressamente previsto no artigo 7º, inciso XXII, no artigo 225, caput e artigo 200, inciso VIII, todos da Carta Magna. Ademais, os valores sociais do trabalho representam pilares da Ordem Econômica (artigo 170 da CF e da Ordem Social (artigo 193 da CF, impondo plena proteção à saúde e à integridade física do trabalhador no meio ambiente onde exerce suas atividades. Desse modo, a questão da reparação dos danos sofridos pelos empregados em função dos acidentes de trabalho e das doenças ocupacionais deve ser analisada dentro do contexto jurídico da proteção ao meio ambiente do trabalho, adotando-se a teoria da responsabilidade civil objetiva, mediante uma interpretação lógico-sistemática e teleológica das normas constitucionais e infraconstitucionais. Essa interpretação evidencia a compatibilização da atividade econômica e da livre iniciativa com os fundamentos do Estado Democrático de Direito, no

  9. Onset of mobility limitations in old age: the combined effect of socioeconomic position and social relations

    DEFF Research Database (Denmark)

    Nilsson, Charlotte Juul; Avlund, Kirsten; Lund, Rikke

    2011-01-01

    Purpose: to examine the combined effect of cohabitation status and social participation, respectively, and socioeconomic position on onset of mobility limitations in a prospective study among older Danes. Design and methods: logistic regression analyses with combined exposure variables were perfo......: the study suggests that future interventions to increase social participation might alleviate the negative effects on mobility experienced by older people in low socioeconomic position, perhaps especially among older males....

  10. Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases

    Directory of Open Access Journals (Sweden)

    Joan E.E. Totté

    2017-05-01

    Full Text Available Staphylococcus aureus plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent S. aureus-related dermatoses were successfully treated with Staphefekt SA.100. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically targets both methicillin-sensitive and methicillin-resistant S. aureus. As a consequence of its specific mechanism of action, bacterial resistance is unlikely to develop. In our 3 cases, resistance induction was not observed. Our results indicate that targeted treatment with Staphefekt might be an attractive alternative for (long-term classical antibiotic therapy, and confirmatory randomized controlled trials are warranted to evaluate its clinical efficacy and safety.

  11. Políticas de saúde materna no Brasil: os nexos com indicadores de saúde materno-infantil Maternal health policies in Brazil: relations to maternal and child health indicators

    Directory of Open Access Journals (Sweden)

    Edson Theodoro dos Santos Neto

    2008-06-01

    Full Text Available Desde o início do processo de medicalização diversos esforços ocorreram para a perpetuação da força de trabalho. Uma das medidas para o exercício do controle estatal foi a institucionalização do parto. Com isso, o entendimento sobre os processos fisiológicos e patológicos referentes à gestante, ao parto e ao recém-nascido avançou nos campos científico e tecnológico, permitindo a intervenção médica para melhoria das condições de saúde materno-infantil. O presente estudo se propõe a identificar as principais legislações que fundamentaram a formulação e a execução de políticas públicas para a saúde materno-infantil no Brasil, a partir da década de 1980, além de estabelecer as relações dessas políticas com indicadores de mortalidade materna e neonatal, no período de 1996 a 2005. Uma pesquisa documental foi realizada para identificar as principais legislações aprovadas e políticas implementadas pelo Ministério da Saúde relacionadas à saúde materno-infantil; enquanto os dados referentes aos indicadores de saúde foram coletados nas bases de dados do SINASC e SIM e disponibilizados on-line. Concluiu-se que as políticas públicas geradas no seio da sociedade pelos movimentos sociais na década de 1980, apesar de seus limites, culminaram na consolidação de diversas leis e programas de saúde voltados à atenção materno-infantil e estas tiveram papel importante na organização dos sistemas e serviços de saúde, de modo a refletir na melhoria dos indicadores de mortalidade neonatal nos anos 1990 e 2000. Entretanto, a persistência dos elevados índices de mortalidade materna leva ao questionamento inevitável de que as políticas de gênero não têm conseguido êxito tão significativo.Since the beginning of the medicalization process, there has been a huge effort towards the maintenance of the working force. One of the measures taken to control the work forces was the institutionalization of delivery

  12. Academic Skills in Children with Early-Onset Type 1 Diabetes: The Effects of Diabetes-Related Risk Factors

    Science.gov (United States)

    Hannonen, Riitta; Komulainen, Jorma; Riikonen, Raili; Ahonen, Timo; Eklund, Kenneth; Tolvanen, Asko; Keskinen, Paivi; Nuuja, Anja

    2012-01-01

    Aim: The study aimed to assess the effects of diabetes-related risk factors, especially severe hypoglycaemia, on the academic skills of children with early-onset type 1 diabetes mellitus (T1DM). Method: The study comprised 63 children with T1DM (31 females, 32 males; mean age 9y 11mo, SD 4mo) and 92 comparison children without diabetes (40…

  13. Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

    Directory of Open Access Journals (Sweden)

    Tianle Chen

    2012-01-01

    work, we use the expectation-maximization (EM algorithm to handle the missing huntingtin gene information in first-degree family members in COHORT, assuming that a family member has the same CAG length as the proband if the family member carries a huntingtin gene mutation. We perform simulation studies to examine performance of the proposed method and apply the methods to analyze COHORT proband and family combined data. Our analyses reveal that the estimated cumulative risk of HD symptom onset obtained from the combined data is slightly lower than the risk estimated from the proband data alone.

  14. Is childhood-onset type I diabetes a wealth-related disease?

    DEFF Research Database (Denmark)

    Patterson, C.C.; Dahlquist, G.; Soltész, G.

    2001-01-01

    AIMS/HYPOTHESIS: To describe the epidemiology of childhood-onset Type I (insulin-dependent) diabetes mellitus in Europe, the EURODIAB collaborative group established prospective, geographically-defined registers of children diagnosed under 15 years of age. A total of 16,362 cases were registered ...... could reflect differences in environmental risk factors such as nutrition or lifestyle that are important in determining a country's incidence rate.......AIMS/HYPOTHESIS: To describe the epidemiology of childhood-onset Type I (insulin-dependent) diabetes mellitus in Europe, the EURODIAB collaborative group established prospective, geographically-defined registers of children diagnosed under 15 years of age. A total of 16,362 cases were registered......-reported associations with milk consumption (r = 0.58), coffee consumption (r = 0.51) and latitude (r = 0.40) were also observed. CONCLUSION/INTERPRETATION: The wide variation in childhood Type I diabetes incidence rates within Europe could be partially explained by indicators of national prosperity. These indicators...

  15. Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset

    Directory of Open Access Journals (Sweden)

    Yu-Dong Xu

    2012-01-01

    Full Text Available Although the beneficial effects of acupuncture in asthma treatment have been well documented, little is known regarding the biological basis of this treatment. Changes in the lung proteome of acupuncture-treated rats with asthma onset were comparatively analyzed using a two-dimensional gel electrophoresis (2DE and mass-spectrometry- (MS- based proteomic approach. Acupuncture on specific acupuncture points appeared to improve respiratory function and reduce the total number of leukocytes and eosinophils in bronchoalveolar lavage fluid in OVA-induced asthma onset. Image analysis of 2DE gels revealed 32 differentially expressed acupuncture-specific protein spots in asthma onset; 30 of which were successfully identified as 28 unique proteins using LC-MS/MS. Bioinformatic analyses indicated that these altered proteins are most likely involved in inflammation-related biological functions, and the functional associations of these proteins result in an inflammation signaling pathway. Acupuncture regulates the pathway at different levels by regulating several key nodal proteins, including downregulating of proinflammatory proteins (e.g., S100A8, RAGE, and S100A11 and upregulating of anti-inflammatory proteins (e.g., CC10, ANXA5, and sRAGE. These deregulated inflammation-related proteins may mediate, at least in part, the antiasthmatic effect of acupuncture. Further functional investigation of these acupuncture-specific effector proteins could identify new drug candidates for the prophylaxis and treatment of asthma.

  16. Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset

    Science.gov (United States)

    Xu, Yu-Dong; Cui, Jian-Mei; Wang, Yu; Yin, Lei-Miao; Gao, Chang-Ke; Liu, Xiao-Yan; Wei, Ying; Liu, Yan-Yan; Jiang, Yong-Liang; Shan, Chun-Xiao; Yang, Yong-Qing

    2012-01-01

    Although the beneficial effects of acupuncture in asthma treatment have been well documented, little is known regarding the biological basis of this treatment. Changes in the lung proteome of acupuncture-treated rats with asthma onset were comparatively analyzed using a two-dimensional gel electrophoresis (2DE) and mass-spectrometry- (MS-) based proteomic approach. Acupuncture on specific acupuncture points appeared to improve respiratory function and reduce the total number of leukocytes and eosinophils in bronchoalveolar lavage fluid in OVA-induced asthma onset. Image analysis of 2DE gels revealed 32 differentially expressed acupuncture-specific protein spots in asthma onset; 30 of which were successfully identified as 28 unique proteins using LC-MS/MS. Bioinformatic analyses indicated that these altered proteins are most likely involved in inflammation-related biological functions, and the functional associations of these proteins result in an inflammation signaling pathway. Acupuncture regulates the pathway at different levels by regulating several key nodal proteins, including downregulating of proinflammatory proteins (e.g., S100A8, RAGE, and S100A11) and upregulating of anti-inflammatory proteins (e.g., CC10, ANXA5, and sRAGE). These deregulated inflammation-related proteins may mediate, at least in part, the antiasthmatic effect of acupuncture. Further functional investigation of these acupuncture-specific effector proteins could identify new drug candidates for the prophylaxis and treatment of asthma. PMID:23304218

  17. Alcohol use in motion pictures and its relation with early-onset teen drinking.

    Science.gov (United States)

    Sargent, James D; Wills, Thomas A; Stoolmiller, Mike; Gibson, Jennifer; Gibbons, Frederick X

    2006-01-01

    Little is known about the impact of viewing depictions of alcohol in entertainment media on adolescent drinking behavior. Our aims were to assess drinking in a sample of popular contemporary movies and to examine the association of movie alcohol exposure with early-onset drinking in an adolescent sample. We conducted a school-based cross-sectional survey (N=4655) with longitudinal follow-up of never-drinkers (N=2406) involving adolescents ages 10-14 years and recruited from 15 New Hampshire and Vermont schools. Screen depictions of alcohol use were timed for each of 601 popular contemporary movies. Each adolescent was asked if he/she had seen a unique list of 50 movie titles, randomly selected from the larger pool. Movie alcohol use was summed for movies the adolescent had seen, adjusted to reflect exposure to the larger pool and modeled as a continuous variable. Ninety-two percent of the movies in the sample depicted drinking; median screen time for movie alcohol use was 2.5 minutes (interquartile range [IQR]: 0.9-5.0 minutes). Median exposure to movie alcohol use from the 601 movies was 8.6 hours (IQR: 4.6-13.5 hours). Overall 23.1% of the cross-sectional sample had tried alcohol, and 14.8% of initial nondrinkers had tried alcohol at the follow-up assessment. We found statistical evidence to support a curvilinear association between higher exposure to movie alcohol use and increased risk of prevalent and incident alcohol use, with a statistically significant linear and quadratic effect, and suggesting a higher dose-effect relationship at lower movie alcohol exposure levels compared to higher levels. The linear and the quadratic associations remained strong and significant in cross-sectional and prospective models after controlling for sociodemographics (grade in school, school, gender, parent education), personality characteristics of the adolescent (sensation seeking, rebelliousness, self-esteem), school performance, parenting style, and smoking experimentation

  18. Changes in infants' affect related to the onset of independent locomotion.

    Science.gov (United States)

    Whitney, Pamela G; Green, James A

    2011-06-01

    Previous research suggests that after gaining several weeks of independent locomotor experience, infants may show both more negative and more positive affect toward parents. However, this prior work has been based largely on parent report, and no studies have used longitudinal or naturalistic methods to chart changes in infants' affective expressions as they gain locomotor ability. Fifteen infants were observed at home before, during, and after learning to crawl in two naturalistic contexts, free play and dyadic play. Expressions of negative affect during free play decreased after the onset of crawling, but there was no change in expressions of positive affect. At the same time, however, mothers reported an increase in both negative and positive reactivity. These results are discussed in terms of the contexts typically assessed during observations and the different sensitivities of mothers to infants' expressions of affect. Several lines of evidence point to a potential role for independent locomotion in the reorganization of affective expressions.

  19. Depression-related work disability: socioeconomic inequalities in onset, duration and recurrence.

    Directory of Open Access Journals (Sweden)

    Jenni Ervasti

    Full Text Available OBJECTIVE: Depression is a major cause of disability in working populations and the reduction of socioeconomic inequalities in disability is an important public health challenge. We examined work disability due to depression with four indicators of socioeconomic status. METHODS: A prospective cohort study of 125 355 Finnish public sector employees was linked to national register data on work disability (>9 days due to depressive disorders (International Classification of Diseases, codes F32-F34 from January 2005 to December 2011. Primary outcomes were the onset of work disability due to depressive disorders and, among those with such disability, return to work after and recurrent episodes of work disability due to depression. RESULTS: We found a consistent inverse socioeconomic gradient in work disability due to depression. Lower occupational position, lower educational level, smaller residence size, and rented (vs. owner-occupied residence were all associated with an increased risk of work disability. Return to work was slower for employees with basic education (cumulative odds ratio = 1.21, 95% CI: 1.05-1.39 compared to those with higher education. Recurrent work disability episodes due to depression were less common among upper-grade non-manual workers (the highest occupational group than among lower-grade non-manual (hazard ratio = 1.16, 95% CI: 1.07-1.25 and manual (hazard ratio = 1.14, 95% CI: 1.02-1.26 workers. CONCLUSIONS: These data from Finnish public sector employees show persistent socioeconomic inequalities in work disability due to depression from 2005 to 2011 in terms of onset, recovery and recurrence.

  20. Depression-related work disability: socioeconomic inequalities in onset, duration and recurrence.

    Science.gov (United States)

    Ervasti, Jenni; Vahtera, Jussi; Pentti, Jaana; Oksanen, Tuula; Ahola, Kirsi; Kivimäki, Mika; Virtanen, Marianna

    2013-01-01

    Depression is a major cause of disability in working populations and the reduction of socioeconomic inequalities in disability is an important public health challenge. We examined work disability due to depression with four indicators of socioeconomic status. A prospective cohort study of 125 355 Finnish public sector employees was linked to national register data on work disability (>9 days) due to depressive disorders (International Classification of Diseases, codes F32-F34) from January 2005 to December 2011. Primary outcomes were the onset of work disability due to depressive disorders and, among those with such disability, return to work after and recurrent episodes of work disability due to depression. We found a consistent inverse socioeconomic gradient in work disability due to depression. Lower occupational position, lower educational level, smaller residence size, and rented (vs. owner-occupied) residence were all associated with an increased risk of work disability. Return to work was slower for employees with basic education (cumulative odds ratio = 1.21, 95% CI: 1.05-1.39) compared to those with higher education. Recurrent work disability episodes due to depression were less common among upper-grade non-manual workers (the highest occupational group) than among lower-grade non-manual (hazard ratio = 1.16, 95% CI: 1.07-1.25) and manual (hazard ratio = 1.14, 95% CI: 1.02-1.26) workers. These data from Finnish public sector employees show persistent socioeconomic inequalities in work disability due to depression from 2005 to 2011 in terms of onset, recovery and recurrence.

  1. Environmental smoking and smoking onset in adolescence: the role of dopamine-related genes. Findings from two longitudinal studies.

    Science.gov (United States)

    Hiemstra, Marieke; Kleinjan, Marloes; van Schayck, Onno C P; Engels, Rutger C M E; Otten, Roy

    2014-01-01

    Although environmental smoking (i.e., paternal and maternal smoking, sibling smoking, and peer smoking) is one of the most important factors for explaining adolescent smoking behavior, not all adolescents are similarly affected. The extent to which individuals are vulnerable to smoking in their environment might depend on genetic factors. The aim of this study was to examine the interplay between environmental smoking and genes encoding components of the dopaminergic system (i.e., dopamine receptor D2, D4, and dopamine transporter DAT1) in adolescent smoking onset. Data from two longitudinal studies were used. Study 1 consisted of 991 non-smoking early adolescents (mean age = 12.52, SD = .57) whereas study 2 consisted of 365 non-smoking middle to late adolescents (mean age = 14.16, SD = 1.07) who were followed for 16 and 48 months, respectively. Logistic regression analyses were conducted using Mplus. In study 1, we found positive associations between parents' and friends' smoking at the first measurement and smoking status 16 months later. In study 2 we found a positive association between friends' smoking and smoking onset 48 months later. Neither study demonstrated any interaction effects of the DRD2, DRD4, or DAT1 genotypes. In conclusion, the effects of environmental smoking on smoking onset are similar for adolescent carriers and non-carriers of these specific genes related to the dopaminergic system.

  2. Environmental smoking and smoking onset in adolescence: the role of dopamine-related genes. Findings from two longitudinal studies.

    Directory of Open Access Journals (Sweden)

    Marieke Hiemstra

    Full Text Available Although environmental smoking (i.e., paternal and maternal smoking, sibling smoking, and peer smoking is one of the most important factors for explaining adolescent smoking behavior, not all adolescents are similarly affected. The extent to which individuals are vulnerable to smoking in their environment might depend on genetic factors. The aim of this study was to examine the interplay between environmental smoking and genes encoding components of the dopaminergic system (i.e., dopamine receptor D2, D4, and dopamine transporter DAT1 in adolescent smoking onset. Data from two longitudinal studies were used. Study 1 consisted of 991 non-smoking early adolescents (mean age = 12.52, SD = .57 whereas study 2 consisted of 365 non-smoking middle to late adolescents (mean age = 14.16, SD = 1.07 who were followed for 16 and 48 months, respectively. Logistic regression analyses were conducted using Mplus. In study 1, we found positive associations between parents' and friends' smoking at the first measurement and smoking status 16 months later. In study 2 we found a positive association between friends' smoking and smoking onset 48 months later. Neither study demonstrated any interaction effects of the DRD2, DRD4, or DAT1 genotypes. In conclusion, the effects of environmental smoking on smoking onset are similar for adolescent carriers and non-carriers of these specific genes related to the dopaminergic system.

  3. The incidence of new onset diabetes after transplantation and related factors: Single center experience.

    Science.gov (United States)

    Sinangil, Ayse; Celik, Vedat; Barlas, Soykan; Koc, Yener; Basturk, Taner; Sakaci, Tamer; Akin, Emin Baris; Ecder, Tevfik

    New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication and is considered a risk factor for patients undergoing renal transplant. The aim of this study was to evaluate the incidence and developing duration of new-onset diabetes after transplant (NODAT) and influencing factors. All patients' data was investigated retrospectively. Diabetics, follow-up period<6 months, age<18years were excluded. Demographic, clinical and laboratory data was recorded. Patients were divided into two groups: with/without NODAT. NODAT group was divided into four subgroups according to the time of developing NODAT, which were 0-3, 3-6, 6-12 and 12 months later. Two groups were compared, to investigate the incidence of NODAT and risk factors associated with the occurrence of NODAT. We retrospectively analyzed the records of 570 patients, of which 420 patients were included. Seventy (16.6%) patients had NODAT (36 female, mean age 51.7±8.2 years, mean follow-up 41.6±21.5 months), 52.8% of patients developed NODAT within the first three months of being diagnosed. 350 patients (116 female, mean age 43.2±12.5 years, mean follow-up 41.6±21.5 months) were without NODAT. The incidence of impaired fasting glucose (IFG) during the first week after transplant was found to be higher in the patients with NODAT (p<0.001). There was positive correlation between NODAT and older age, obesity, family history of diabetes, presence of IFG, fasting plasma glucose, total and LDL-cholesterol, triglycerides, parathormone. Old age, obesity, presence of IFG, pretransplant hypertriglyceridemia and hyperparathyroidism were predictors of development of NODAT. Incidence of NODAT, especially the first six months, was high. All patients should be screened for IFG within the first week. Patients with dyslipidemia, elderly and obese patients should be closely monitored for the risk of development of NODAT. Copyright © 2017 Sociedad Española de Nefrología. Published by Elsevier España, S

  4. Do online assessed self-report and behavioral measures of impulsivity-related constructs predict onset of substance use in adolescents?

    NARCIS (Netherlands)

    Janssen, Tim; Larsen, Helle; Peeters, Margot; Boendermaker, Wouter; Vollebergh, Wilma; Wiers, Reinout

    2015-01-01

    Abstract Introduction To prospectively predict the onset of use of alcohol, cigarettes and marijuana among Dutch adolescents, using behavioral and self-report measures of impulsivity-related facets. Specifically, we investigated whether behavioral measures of impulsivity predicted the onset of subst

  5. Loss of independent limb control in childhood hemiparesis is related to time of brain injury onset.

    Science.gov (United States)

    Sukal-Moulton, Theresa; Murray, Theresa M; Dewald, Julius P A

    2013-03-01

    This study investigated the presence of inter-limb activity at the elbow joint in individuals with childhood-onset hemiparesis, including spontaneous mirror movements during unilateral tasks and the ability to suppress them during bilateral tasks. Eighteen individuals with hemiparesis were divided into three categories of injury timing: before birth (PRE-natal), around the time of birth (PERI-natal), and after 6 months of age (POST-natal). Individuals with hemiparesis, as well as 12 typically developing peers, participated in unilateral and bilateral elbow flexion and extension tasks completed at maximal and submaximal effort while muscle activity was monitored and motor output was quantified by two multiple degrees-of-freedom load cells. Significantly, higher levels of paretic elbow flexion were found only in the PRE- and PERI-natal groups during the flexion of the non-paretic limb, which was modulated by effort level in both unilateral and bilateral tasks. The bilateral activation of elbow flexors in the PRE-/PERI-natal groups indicates potential use of a common cortical command source to drive both upper extremities, while the POST-natal/typically developing groups' flexors appear to receive input from different supraspinal structures.

  6. Anosognosia and Its Relation to Psychiatric Symptoms in Early-Onset Alzheimer Disease.

    Science.gov (United States)

    Yoon, Bora; Shim, Yong S; Hong, Yun Jeong; Choi, Seong Hye; Park, Hee Kyung; Park, Sun Ah; Jeong, Jee Hyang; Yoon, Soo Jin; Yang, Dong-Won

    2017-05-01

    We investigated differences in the prevalence of anosognosia and neuropsychiatric symptoms (NPSs) characteristics according to disease severity in patients with early-onset Alzheimer disease (EOAD). We recruited 616 patients with EOAD. We subdivided participants into 2 groups based on the presence or absence of anosognosia and then again by Clinical Dementia Rating (CDR) scale. We compared the differences in the Neuropsychiatric Inventory (NPI) scores according to anosognosia and disease severity. The percentage of patients with anosognosia in each CDR group steadily increased as the CDR rating increased (CDR 0.5 8.6% vs CDR 1 13.6% vs CDR 2 26.2%). The NPI total score was significantly higher in patients with anosognosia in the CDR 0.5 and 1 groups; by contrast, it had no association in the CDR 2 group. Frontal lobe functions were associated with anosognosia only in the CDR 0.5 and 1 groups. After stratification by CDR, in the CDR 0.5 group, the prevalence of agitation ( P = .040) and appetite ( P = .013) was significantly higher in patients with anosognosia. In the CDR 1 group, patients with anosognosia had a significantly higher prevalence of delusions ( P = .032), hallucinations ( P = .048), and sleep disturbances ( P = .047). In the CDR 2 group, we found no statistical difference in the frequency of symptoms between patients with and without anosognosia. These results confirm that the prevalence of anosognosia as well as the individual NPS and cognitive functions associated with it differ according to EOAD severity.

  7. Study of relation between the onset age of type 1 diabetes and celiac disease in children andadole scents

    Directory of Open Access Journals (Sweden)

    robabe Ghergherehchi

    2010-02-01

    Full Text Available Celiac disease (CD is a chronic enteropathy caused by hypersensitivity to gluten. Most studies have showed more prevalence of CD in the patients with diabetes mellitus type 1. Both diseases are autoimmune and their incidence is related to inheritance and environmental factors. The aim of this research is the study of relation between CD prevalence and diabetic age onset. Materials and Methods: In this descriptive cross-sectional study, 135 children with diabetes mellitus type 1 referring to Tabriz children hospital endocrine department and clinic between 2006-2008 were selected. After filling individual identity of the patients and the measurement of weight and height, the serumic level of anti-tissue Trans glutaminase IgA antibody (A-tTG-A-IgA, anti endomisial IgA antibody (AEA-IgA and anti-gliadin IgG antibody (AGA-IgG were measured. In the case that A-tTG-A either AEA alone or with AGA was high, small intestinal biopsy was preformed. The data was analysed using SPSS ver 16 software. Results: 28 of 135 patients with diabetes mellitus type 1, were serologically positive for celiac. Confirmed celiac prevalence based on biopsy was 6. 8%. From diabetic age onset and celiac incidence point of view there was not any significant relation (P=0. 996. Conclusion: Celiac disease in type1 diabetic patients dose not have correlation with the onset age of type 1 diabetes and diabetic patients should be followed up from celiac point of view during treatment and prevention.

  8. Insulin-Like Growth Factor 1 and Related Compounds in the Treatment of Childhood-Onset Neurodevelopmental Disorders

    Science.gov (United States)

    Vahdatpour, Cyrus; Dyer, Adam H.; Tropea, Daniela

    2016-01-01

    Insulin-Like Growth Factor 1 (IGF-1) is a neurotrophic polypeptide with crucial roles to play in Central Nervous System (CNS) growth, development and maturation. Following interrogation of the neurobiology underlying several neurodevelopmental disorders and Autism Spectrum Disorders (ASD), both recombinant IGF-1 (mecasermin) and related derivatives, such as (1-3)IGF-1, have emerged as potential therapeutic approaches. Clinical pilot studies and early reports have supported the safety/preliminary efficacy of IGF-1 and related compounds in the treatment of Rett Syndrome, with evidence mounting for its use in Phelan McDermid Syndrome and Fragile X Syndrome. In ASD, clinical trials are ongoing. Here, we review the role of IGF-1 in the molecular etiologies of these conditions in addition to the accumulating evidence from early clinical studies highlighting the possibility of IGF-1 and related compounds as potential treatments for these childhood-onset neurodevelopmental disorders. PMID:27746717

  9. Insulin-Like Growth Factor 1 and Related Compounds in the Treatment of Childhood-Onset Neurodevelopmental Disorders

    Directory of Open Access Journals (Sweden)

    Cyrus Vahdatpour

    2016-09-01

    Full Text Available Insulin-Like Growth Factor 1 (IGF-1 is a neurotrophic polypeptide with crucial roles to play in Central Nervous System (CNS growth, development and maturation. Following interrogation of the neurobiology underlying several neurodevelopmental disorders and Autism Spectrum Disorders (ASD, both recombinant IGF-1 (mecasermin and related derivatives, such as (1-3 IGF-1, have emerged as potential therapeutic approaches. Clinical pilot studies and early reports have supported the safety/preliminary efficacy of IGF-1 and related compounds in the treatment of Rett Syndrome, with evidence mounting for its use in Phelan McDermid Syndrome and Fragile X Syndrome. In broader ASD, clinical trials are ongoing. Here, we review the role of IGF-1 in the molecular etiologies of these conditions in addition to the accumulating evidence from early clinical studies highlighting the possibility of IGF-1 and related compounds as potential treatments for these childhood-onset neurodevelopmental disorders.

  10. Direct diabetes-related costs in young patients with early-onset, long-lasting type 1 diabetes.

    Directory of Open Access Journals (Sweden)

    Christina Bächle

    Full Text Available OBJECTIVE: To estimate diabetes-related direct health care costs in pediatric patients with early-onset type 1 diabetes of long duration in Germany. RESEARCH DESIGN AND METHODS: Data of a population-based cohort of 1,473 subjects with type 1 diabetes onset at 0-4 years of age within the years 1993-1999 were included (mean age 13.9 (SD 2.2 years, mean diabetes duration 10.9 (SD 1.9 years, as of 31.12.2007. Diabetes-related health care services utilized in 2007 were derived from a nationwide prospective documentation system (DPV. Health care utilization was valued in monetary terms based on inpatient and outpatient medical fees and retail prices (perspective of statutory health insurance. Multiple regression models were applied to assess associations between direct diabetes-related health care costs per patient-year and demographic and clinical predictors. RESULTS: Mean direct diabetes-related health care costs per patient-year were €3,745 (inter-quartile range: 1,943-4,881. Costs for glucose self-monitoring were the main cost category (28.5%, followed by costs for continuous subcutaneous insulin infusion (25.0%, diabetes-related hospitalizations (22.1% and insulin (18.4%. Female gender, pubertal age and poor glycemic control were associated with higher and migration background with lower total costs. CONCLUSIONS: Main cost categories in patients with on average 11 years of diabetes duration were costs for glucose self-monitoring, insulin pump therapy, hospitalization and insulin. Optimization of glycemic control in particular in pubertal age through intensified care with improved diabetes education and tailored insulin regimen, can contribute to the reduction of direct diabetes-related costs in this patient group.

  11. Use of ceramides and related products for childhood-onset eczema.

    Science.gov (United States)

    Hon, Kam L; Leung, Alexander K C

    2013-01-01

    Atopic eczema or dermatitis (AD) is a chronically relapsing dermatosis associated with pruritus, sleep disturbance and impaired quality of life. AD affects 10 to 20% of school-aged children. The prevalence has increased two to three folds over the past three decades in industrialized countries and there is evidence to suggest that this prevalence is increasing. AD is frustrating to both patients and caregivers and can impose considerable financial impact on the families. The pruritus and sleep disturbance can be intractable and the disease has important physical and psychological implications. Filaggrin (filament-aggregating protein) has an important function in epidermal differentiation and barrier function. Null mutations within the filaggrin gene cause ichthyosis vulgaris and are major risk factors for developing AD. The affected skin of atopic individuals is deficient in natural moisturizing factors (derived from deiminated filaggrin peptides filaggrin) or ceramides (a family of lipid molecules, composed of sphingosine and a fatty acid, found in high concentrations within the cell membrane of cells in the stratum corneum). Avoidance of triggering factors, optimal skin care and topical corticosteroids are the mainstay of therapy for AD. There are two important dermatologic facets to its management, namely, preventive and therapeutic measures. Preventive measures refer to the frequent and proper application of skin moisturizers. When these preventive measures fail to control the disease exacerbation, therapeutic measures such as topical/systemic corticosteroids, antibiotics and immunomodulating agents may be required to control the skin inflammation. Proper moisturizer therapy can reduce the frequency of flares and the demand of topical corticosteroids or topical calcineurin inhibitors. Regular topical application of a moisturizer is the key in the management of patients with AD. Moisturizer therapy of childhood-onset AD is significantly complicated by the

  12. The Impact of Vocal Hyperfunction on Relative Fundamental Frequency during Voicing Offset and Onset

    Science.gov (United States)

    Stepp, Cara E.; Hillman, Robert E.; Heaton, James T.

    2010-01-01

    Purpose: This study tested the hypothesis that individuals with vocal hyperfunction would show decreases in relative fundamental frequency (RFF) surrounding a voiceless consonant. Method: This retrospective study of 2 clinical databases used speech samples from 15 control participants and women with hyperfunction-related voice disorders: 82 prior…

  13. Individual traffic-related air pollution and new onset adult asthma: A GIS-based pilot study

    Energy Technology Data Exchange (ETDEWEB)

    Sherson, D.; Lysbeck Hansen, C. (Hospital of Vejle, Dept. of Occupational and Environmental Medicine, (Denmark)); Solvang Jensen, S.; Hertel, O. (Univ. of Aarhus, National Environmental Research Institute (Denmark)); Baelum, J. (Odense Univ. Hospital, Dep. of Occupational and Environmental Medicine (Denmark)); Skadhauge, L. (Haderslev Hospital, Dep. of Occupational and Environmental Medicine (Denmark)); Siersted, H.C. (Odense Univ. Hospital, Dep. of Respiratory Medicine (Denmark)); Omland, OE. (Aalborg Hospital, Dep. of Occupational Medicine (Denmark)); Thomsen, G. (South-West Jutland Hospital Esbjerg, Dep. of Occupational and Environmental Medicine (Denmark)); Sigsgaard, T. (Univ. of Aarhus, Institute of Occupational and Environmental Medicine (Denmark))

    2008-03-15

    The objective of this pilot study is to investigate the relation between asthma and wheeze debut and individually estimated exposure to traffic-related air pollutants with a validated exposure system (AirGIS). A non-smoking cohort with recently acquired asthma or wheeze as well as matched controls was identified from a large cross-sectional study. All residential and working addresses with corresponding time periods for a 10 year period were successfully identified for all study participants (N=33) and exposure estimated for both urban background and street level. Individual levels of air pollutants in the years preceding debut of asthma or wheeze were analyzed using survival analysis. No significant correlations between exposure levels and onset of disease or symptom were demonstrated. A tendency towards higher levels of nitrogen oxides exposure during the year prior to debut was seen in wheeze cases. Substantial problems in determining time of onset were encountered. It is recommended that the analytic methods developed in this pilot study are used in a larger prospective cohort to investigate individual trafficrelated air pollutants as a risk factor for the development of new asthma and wheeze. (au)

  14. Short lasting activity-related headaches with sudden onset in children: a case-based reasoning on classification and diagnosis

    Science.gov (United States)

    2013-01-01

    Background Short lasting headaches related to activity or cough are rare, particularly in childhood, and can be difficult to diagnose, especially in young children who are not able to describe their symptoms. In the literature there are few data on this topic in adults and the paediatric cases reported are even more rare. Findings We present the clinical history of a 7-year-old child and a 3-year-old child both diagnosed as having activity-related headaches, characterized by sudden onset of short lasting (few seconds) attacks, that were triggered by cough or exercise. There were no accompanying symptoms and the neurological examination was normal in both cases. Brain magnetic resonance imaging showed, in the first case, a cerebellar pilocytic astrocytoma and, in the second case, a Chiari 1 malformation. Both cases received an early diagnosis, were surgically treated and had a good prognosis at follow-up. Conclusions When headache has a recent onset, it presents suddenly, and it is triggered by strain, even with normal neurological examination, neuroimaging is mandatory in order to exclude secondary headaches, especially in children. PMID:23565626

  15. Relative fundamental frequency during vocal onset and offset in older speakers with and without Parkinson's disease.

    Science.gov (United States)

    Stepp, Cara E

    2013-03-01

    The relative fundamental frequency (RFF) surrounding production of a voiceless consonant has previously been shown to be lower in speakers with hypokinetic dysarthria and Parkinson's disease (PD) relative to age/sex matched controls. Here RFF was calculated in 32 speakers with PD without overt hypokinetic dysarthria and 32 age and sex matched controls to better understand the relationships between RFF and PD progression, medication status, and sex. Results showed that RFF was statistically significantly lower in individuals with PD compared with healthy age-matched controls and was statistically significantly lower in individuals diagnosed at least 5 yrs prior to experimentation relative to individuals recorded less than 5 yrs past diagnosis. Contrary to previous trends, no effect of medication was found. However, a statistically significant effect of sex on offset RFF was shown, with lower values in males relative to females. Future work examining the physiological bases of RFF is warranted.

  16. On the relative importance of magnetospheric and ionospheric processes during substorm onset and expansion: A case study

    Science.gov (United States)

    Lopez, Ramon E.

    1992-01-01

    The question of whether substorm onset is triggered in the magnetotail or the ionosphere is presented. The possible influence of the ionosphere in the subsequent development of a substorm is discussed. Theoretical considerations involved are reviewed and a case study to address this question is examined. The evidence indicates that magnetotail processes initiate the sequence of events called a substorm, while the ionosphere appears to play a critical role in the subsequent evolution of the substorm expansion phase. However, the necessary observations, in particular high time resolution coordinated observations in the ionosphere and magnetotail are relatively rare. Continued examination of existing ground and space based data sets, in particular underutilized observations such as the Scatha data, may provide a more solid foundation for clarifying this issue and determining the relative importance of magnetospheric and ionospheric processes during substorms.

  17. The Relationship between Perception of Vocal Effort and Relative Fundamental Frequency during Voicing Offset and Onset

    Science.gov (United States)

    Stepp, Cara E.; Sawin, Devon E.; Eadie, Tanya L.

    2012-01-01

    Purpose: In this study, the authors aimed to determine the relationship between relative fundamental frequency (RFF) and listener perception of vocal effort in individuals with varying degrees of vocal hyperfunction. Method: Thirty women diagnosed with voice disorders commonly associated with vocal hyperfunction and 10 healthy women provided…

  18. Cryptogenic localization-related epilepsy with childhood onset: The problem of definition and prognosis.

    NARCIS (Netherlands)

    Reijs, R.P.; Mil, S.G. van; Hall, M.H. van; Arends, J.B.; Weber, J.W.; Renier, W.O.; Aldenkamp, A.P.

    2006-01-01

    BACKGROUND: Up to one-third of children with epilepsy are diagnosed with cryptogenic localization-related epilepsy (CLRE). CLRE is a large nonspecific category within the ILAE classification. For this population no unequivocal prognosis exists. METHODS: Twenty-five articles describing aspects of CLR

  19. Assessing Age-Related Etiologic Heterogeneity in the Onset of Islet Autoimmunity

    Directory of Open Access Journals (Sweden)

    Brittni N. Frederiksen

    2015-01-01

    Full Text Available Type 1 diabetes (T1D, a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that differentially influence the disease process at certain ages by assessing age-related heterogeneity. The Diabetes Autoimmunity Study in the Young (DAISY has followed 2,547 children at increased genetic risk for T1D from birth since 1993 in Denver, Colorado, 188 of whom developed IA. Using the DAISY population, we evaluated putative determinants of IA, including non-Hispanic white (NHW ethnicity, maternal age at birth, and erythrocyte membrane n-3 fatty acid (FA levels, for age-related heterogeneity. A supremum test, weighted Schoenfeld residuals, and restricted cubic splines were used to assess nonproportional hazards, that is, an age-related association of the exposure with IA risk. NHW ethnicity, maternal age, and erythrocyte membrane n-3 FA levels demonstrated a significant age-related association with IA risk. Assessing heterogeneity in disease etiology enables researchers to identify associations that may lead to better understanding of complex chronic diseases.

  20. Cryptogenic localization-related epilepsy with childhood onset: The problem of definition and prognosis.

    NARCIS (Netherlands)

    Reijs, R.P.; Mil, S.G. van; Hall, M.H. van; Arends, J.B.; Weber, J.W.; Renier, W.O.; Aldenkamp, A.P.

    2006-01-01

    BACKGROUND: Up to one-third of children with epilepsy are diagnosed with cryptogenic localization-related epilepsy (CLRE). CLRE is a large nonspecific category within the ILAE classification. For this population no unequivocal prognosis exists. METHODS: Twenty-five articles describing aspects of CLR

  1. Child Maltreatment and Onset of Emergency Department Presentations for Suicide-Related Behaviors

    Science.gov (United States)

    Rhodes, Anne E.; Boyle, Michael H.; Bethell, Jennifer; Wekerle, Christine; Goodman, Deborah; Tonmyr, Lil; Leslie, Bruce; Lam, Kelvin; Manion, Ian

    2012-01-01

    Objectives: To determine whether the rates of a first presentation to the emergency department (ED) for suicide-related behavior (SRB) are higher among children/youth permanently removed from their parental home because of substantiated maltreatment than their peers. To describe the health care settings accessed by these children/youth before a…

  2. A THEORETICAL STUDY ON THE MULTIPLE EQUILIBRIA OF TROPICAL ATMOSPHERE AND THEIR RELATION TO THE ONSET OF THE SUMMER MONSOON

    Institute of Scientific and Technical Information of China (English)

    ZHAO Nan; DING Yi-hui; Masaaki Takahashi; SHEN Xin-yong

    2006-01-01

    Multiple equilibria and their stability in tropical atmosphere are investigated through β -plane barotropic models with consideration of heating and dissipation. We have derived the solutions of the model equations corresponding to the multiple equilibria or the steady flows first, and then establish the criteria for the stability of steady flow by use of the Liapunov direct Method. When these criteria are applied to the solutions of equilibria obtained, stable flows, which are closely related to the different patterns of quasi-stationary circulation in the tropical region, are found. The configurations of these stable flows and the shift between two of them as season changes provide quite reasonable explanations to many fundamental problems of tropical circulation features such as the catastrophe mechanism of the onset and the break-active cycle of the Asian summer monsoon. It follows that the onset or the abrupt transition of the Asian summer monsoon could be attributed to the multiple equilibrium property of the tropical circulation resulted from the advective nonlinearity, which provide another explanation among others.

  3. Influence of Tailored Applied Magnetic Fields on High-Power MPD Thruster Current Transport and Onset-Related Phenomena

    Science.gov (United States)

    Moeller, Robert C.; Polk, James E.

    2013-01-01

    magnetic field configurations enabled significant reductions in onset-related behaviors relative to self-field operation. These improvements should lead to reduced anode erosion, i.e., improved thruster lifetime, and increased thruster efficiency with the applied fields. The applied fields used in this study differ from both the topologies and relative field strengths typically used in the vast majority of conventional, so-called "applied-field MPD thrusters" (AF-MPDTs). These results suggest a distinctive and more effective approach to influencing the near-anode phenomena and mitigating the deleterious effects of onset with appropriately designed applied magnetic fields.

  4. Influence of Tailored Applied Magnetic Fields on High-Power MPD Thruster Current Transport and Onset-Related Phenomena

    Science.gov (United States)

    Moeller, Robert C.; Polk, James E.

    2013-01-01

    magnetic field configurations enabled significant reductions in onset-related behaviors relative to self-field operation. These improvements should lead to reduced anode erosion, i.e., improved thruster lifetime, and increased thruster efficiency with the applied fields. The applied fields used in this study differ from both the topologies and relative field strengths typically used in the vast majority of conventional, so-called "applied-field MPD thrusters" (AF-MPDTs). These results suggest a distinctive and more effective approach to influencing the near-anode phenomena and mitigating the deleterious effects of onset with appropriately designed applied magnetic fields.

  5. Aging related erectile dysfunction—potential mechanism to halt or delay its onset

    Science.gov (United States)

    Gonzalez-Cadavid, Nestor F.; Rajfer, Jacob

    2017-01-01

    Erectile dysfunction (ED) will visit every man at some time in his life. The age at when that knock on the door is heard is totally dependent on one’s genetics as well as other extrinsic factors. Unlike guests who come for a visit and then leave, once ED shows up it tends to hang around forever. To add insult to injury, the longer ED hangs around, the worse it will get. It is estimated that by the time a man is in his 40’s, he has about a 40% chance of having some form of ED and this prevalence increases about 10% per decade thereafter. This suggests that the aging related process that leads to ED begins early in life. It turns out that the most common cause of ED, regardless of the patient’s age, is due to a problem with the vascular system of the penis. However, this specific aging related vascular problem is not caused by arterial disease but due to a dysfunction and/or loss of the corporal smooth muscle cells (SMC), the main constituent of the corporal sinusoids. As one gets older, these SMC continue to degrade and disappear. When approximately 15% of these cells have been impacted, it results in an inability of the corporal tissue to retain and/or prevent the blood from “leaking” out of the corporal sinusoids into the systemic veins. However, the corporal SMC themselves begin to combat this aging process by expressing the inducible nitric oxide synthase (iNOS) enzyme to make nitric oxide (NO) in an attempt to quench the high intracellular oxidative stress responsible for the SMC apoptosis. When this iNOS pathway is then pharmacologically upregulated, reversal of these aging related changes in the corpora with correction of the venous leakage is observed. Since we believe that aging related ED is pathologically the same disorder as essential hypertension, the development of a therapeutic regimen that can halt, delay or possibly reverse the cellular processes that lead to aging related ED should also be applicable to those patients diagnosed with

  6. The onset of pain related behaviours following partial beak amputation in the chicken.

    Science.gov (United States)

    Gentle, M J; Hunter, L N; Waddington, D

    1991-07-08

    The number of pecks delivered by birds to an attractive visual stimulus was measured before and again 6, 26 and 32 h after partial beak amputation. There was a significant reduction in the number of pecks by birds 26 h after amputation but not at 6 h after. This reduction was considered to be a quantitative measure of pain related guarding behaviour. The results indicated the presence of a pain-free period immediately following amputation which may last in some birds for as long as 26 h.

  7. Health-related services use and the onset of functional disability: 10 year follow-up study.

    Science.gov (United States)

    Chen, Chun-Min; Su, Yung-Yu; Lan, Tzuo-Yun; Mullan, Judy; Shi, Hon-Yi; Chiu, Herng-Chia

    2014-01-01

    This study aimed to examine the effect of health-related service use on the development of functional disability in an older adult Taiwanese cohort. The sample population consisted of 871 participants without Instrumental Activities of Daily Living (IADL) disabilities, 1061 participants without Activities of Daily Living (ADL) disabilities and 817 participants without IADL and ADL disabilities at baseline. The onset of IADL and ADL disabilities were estimated as the follow-up survey year that these functional disabilities were first noted, or the follow-up survey year that the participant was noted as having died. A Cox proportional hazards model, with time-dependent covariates, was used to analyze the association between the time of onset of the functional disabilities and the health-related service use, after controlling for age, gender, education, marital status and time varying chronic disease status. This study found that an increase in the number of services used by the participants resulted in fewer IADL and ADL disabilities. Furthermore, participants who attended recreational programs, regular health examinations, and who received the information assistance and meal preparation were significantly less likely to develop disabilities. Participants who used one or more services were 55-77% less likely to be IADL disabled, and were 54-81% less likely to be ADL disabled, and were also 59-89% less likely to develop IADL and ADL disabilities as compared to those who used none. In the present study therefore, as the number of health services used increased the likelihood of developing a functional disability decreased.

  8. A polymorphism in the human agouti-related protein is associated with late-onset obesity.

    Science.gov (United States)

    Argyropoulos, George; Rankinen, Tuomo; Neufeld, Doni R; Rice, Treva; Province, Michael A; Leon, Arthur S; Skinner, James S; Wilmore, Jack H; Rao, D C; Bouchard, Claude

    2002-09-01

    The mouse agouti-related protein (AGRP) is a powerful appetite effector that results in hyperphagia and the development of obesity when administered intracerebroventricularly or when overexpressed in transgenic mice. Animal studies have also shown that exogenous administration of AGRP predisposes toward hedonic intake of high fat and high sucrose diets. The human ortholog (hAGRP) maps on chromosome 16q22 and has similar physiological properties, as tested in animal models. A polymorphism was identified in the third exon of hAGRP, c.199G-->A, that resulted in a nonconservative amino acid substitution, Ala(67)Thr. Computational analysis of the protein showed significant differences in the coils of the two polymorphic isoforms of the protein. Human studies showed no genotype effects in individuals with a mean age of 25 yr. However, the G/G genotype was significantly associated with fatness and abdominal adiposity in the parental population with a mean age of 53 yr. The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion.

  9. Lingon sa Iskolarsyip sa Dulaan (1948-2007 Looking Back on Theater Scholarship (1948-2007

    Directory of Open Access Journals (Sweden)

    Apolonio B. Chua

    2012-12-01

    Full Text Available From 1948 to 2007, the academic community produced about a hundred titles of theses and dissertations on drama and theater, or made use of data from drama and theater for larger spheres of studies. The current article looked into identifying trends and points of emphasis, as the researches and studies progressed through roughly half a century of research production in the academic setting. Inductive in approach and tentative and exploratory in its analysis, the study identified four trends and points of emphasis in research production. In the fifties and sixties, the emphasis was more on studying the play text or drama; studies veered towards a literary reading and orientation. Eventually, this trend gave way to studying the larger phenomenon of mounting, and the mise en scéne and the spectator became additional units of concern for research. Studies began to have sections on props, costumes, and staging techniques. In the eighties, a larger concern for looking at theater as social production followed. Participant observation, field work and ethnography gave equal emphasis on the social context of theater. Marxism and other perspectives from the social sciences framed theater studies then; correlations between theater and society became useful. Towards the last decade of the century, theater studies aimed at a more conceptual approach, emphasizing core concepts like panata and other related or equivalent terms, elevating and defining the study of theater as a study of culture itself. Gamit ang mahigit sa sandaang tesis at disertasyon hinggil sa dula at dulaan o sinasangkot ang mga ito na lumabas sa akademya mula 1948 hanggang 2007, kapwa sa Unibersidad ng Pilipinas at sa iba pa, nilayon ng “Lingon sa Iskolarsyip sa Dulaan (1948-2007” na pulsuhan ang pangkalahatang daloy, tutok, tunguhin o kalakaran sa pagdadala ng mga pag-aaral. Panimula at exploratory sa inductive nitong lapat, nakatukoy ang pag-aaral ng apat na sapit o tutok sa daloy ng

  10. ARE DECAYING MAGNETIC FIELDS ABOVE ACTIVE REGIONS RELATED TO CORONAL MASS EJECTION ONSET?

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, J. [Department of Astronomy, University of California, Berkeley, CA 94720-7450 (United States); Welsch, B. T.; Li, Y. [Space Sciences Laboratory, University of California, Berkeley, CA 94720-7450 (United States)

    2012-10-10

    Coronal mass ejections (CMEs) are powered by magnetic energy stored in non-potential (current-carrying) coronal magnetic fields, with the pre-CME field in balance between outward magnetic pressure of the proto-ejecta and inward magnetic tension from overlying fields that confine the proto-ejecta. In studies of global potential (current-free) models of coronal magnetic fields-Potential Field Source Surface (PFSS) models-it has been reported that model field strengths above flare sites tend to be weaker when CMEs occur than when eruptions fail to occur. This suggests that potential field models might be useful to quantify magnetic confinement. One straightforward implication of this idea is that a decrease in model field strength overlying a possible eruption site should correspond to diminished confinement, implying an eruption is more likely. We have searched for such an effect by post facto investigation of the time evolution of model field strengths above a sample of 10 eruption sites. To check if the strengths of overlying fields were relevant only in relatively slow CMEs, we included both slow and fast CMEs in our sample. In most events we study, we find no statistically significant evolution in either (1) the rate of magnetic field decay with height, (2) the strength of overlying magnetic fields near 50 Mm, or (3) the ratio of fluxes at low and high altitudes (below 1.1 R{sub Sun }, and between 1.1 and 1.5 R{sub Sun }, respectively). We did observe a tendency for overlying field strengths and overlying flux to increase slightly, and their rates of decay with height to become slightly more gradual, consistent with increased confinement. The fact that CMEs occur regardless of whether the parameters we use to quantify confinement are increasing or decreasing suggests that either (1) the parameters that we derive from PFSS models do not accurately characterize the actual large-scale field in CME source regions, (2) systematic evolution in the large-scale magnetic

  11. Fatores determinantes da carga de trabalho em uma unidade básica de saúde Decisive factors relating to workload in a primary healthcare unit

    Directory of Open Access Journals (Sweden)

    Nilson Rogério da Silva

    2011-08-01

    Full Text Available As doenças decorrentes do exercício pro-fissional, sejam de ordem física ou emocional, têm apresentado aumento crescente na sociedade atual, nos diferentes segmentos laborativos, com projeção significativa junto aos profissionais da saúde como médicos, dentistas, enfermeiros, auxiliares de enfermagem e auxiliares administrativos envolvidos com a prestação de serviços nas unidades de saúde. Este estudo teve por objetivo conhecer a carga de trabalho e seus fatores determinantes, buscando identificar possíveis relações entre as condições de trabalho e o possível impacto para a saúde dos trabalhadores. Participaram da amostra 31 indivíduos: 12 médicos, 3 dentistas, 1 enfermeira, 9 auxiliares de enfermagem, 3 auxiliares odontológicos e 3 auxiliares administrativos de uma Unidade Básica de Saúde (UBS no interior de São Paulo. Para a coleta dos dados foi elaborado um roteiro de entrevista estruturado e realizadas reuniões com os grupos específicos para uma descrição detalhada das atividades realizadas em cada setor e o levantamento de problemas e de características desejáveis. Os resultados indicam a presença de carga física, carga cognitiva e carga psíquica; processo de comunicação inadequado; equipamentos obsoletos; número excessivo de usuários e estrutura frágil para lidar com absenteísmo.Work-related diseases o either physical or emotional origin have been on the increase in contemporary society in the different work sectors. They have had a profound impact on health professionals, such as physicians, dentists, nurses, nursing assistants and administrative assistants in the primary healthcare units. This study aimed to establish the decisive factors relating to workload, seeking to identify possible relations between the working conditions and their potential impact on worker health. Thirty-one individuals comprised the sample, namely 12 physicians, 3 dentists, 1 nurse, 9 nursing assistants, 3 dental

  12. A Holocene Sediment Record From Lake Elsinore, Southern California: Evidence for Relative Lake Level Change and the Onset of ENSO.

    Science.gov (United States)

    Kirby, M. E.; Lund, S. P.; Poulsen, C. J.

    2003-12-01

    precipitation became more vigorous during the mid-Holocene (i.e., an increase in winter precipitation via an increase in the passage of winter cyclones). Because precipitation amount in coastal southwestern North America is so closely linked to ENSO variability, we further suggest that our observations support the hypothesis that modern ENSO variability and conditions developed during the mid-Holocene. This statement is in concert with recent findings from South America and the western Pacific that suggest a mid-Holocene onset of modern ENSO conditions. Our results are also supported by the recently published isotope data from Santa Barbara Basin (Friddell et al., 2003), which indicate an increase in more frequent "warm" ENSO events during the mid-Holocene. Our findings add to the growing number of terrestrial archives that document ENSO related Holocene variability and its timing of onset.

  13. Heritability, parental transmission and environment correlation of pediatric-onset type 2 diabetes mellitus and metabolic syndrome-related traits.

    Science.gov (United States)

    Miranda-Lora, América L; Vilchis-Gil, Jenny; Molina-Díaz, Mario; Flores-Huerta, Samuel; Klünder-Klünder, Miguel

    2017-04-01

    To estimate the heritability, parental transmission and environmental contributions to the phenotypic variation in type 2 diabetes mellitus and metabolic syndrome-related traits in families of Mexican children and adolescents. We performed a cross-sectional study of 184 tri-generational pedigrees with a total of 1160 individuals (99 families with a type 2 diabetes mellitus proband before age 19). The family history of type 2 diabetes mellitus in three generations was obtained by interview. Demographic, anthropometric, biochemical and lifestyle information was corroborated in parents and offspring. We obtained correlations for metabolic traits between relative pairs, and variance component methods were used to determine the heritability and environmental components. The heritability of early-onset of type 2 diabetes mellitus was 0.50 (p0.50) for blood pressure, HbA1c and HDL-cholesterol after multivariate adjustment (pdiabetes mellitus and insulin resistance, were significantly correlated only through the mother and others, such as hypertriglyceridemia, were significantly correlated only through the father. This study demonstrates that type 2 diabetes mellitus and metabolic syndrome-related traits are highly heritable among Mexican children and adolescents. Furthermore, several cardiometabolic factors have strong heritability and/or high environmental contributions that highlight the complex architecture of these alterations. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Poorer functionality is related to better quality of life response following the use of biological drugs: 6-month outcomes in a prospective cohort from the Public Health System (Sistema Único de Saúde), Minas Gerais, Brazil.

    Science.gov (United States)

    de Oliveira Junior, Haliton Alves; dos Santos, Jéssica Barreto; Acurcio, Francisco Assis; Almeida, Alessandra Maciel; Kakehasi, Adriana Maria; Alvares, Juliana; de Carvalho, Luis Fernando Duarte; Cherchiglia, Mariangela Leal

    2015-06-01

    We aim to analyze factors associated with the quality of life (QOL) response of individuals with rheumatic diseases treated by the Public Health System (Sistema Único de Saúde) with biological disease-modifying antirheumatic drugs (bDMARDs). Data from 428 patients using bDMARDs were collected using a standardized form at baseline and 6 months after the onset of treatment. The average reduction of the scores on EuroQol-five dimension was 0.11 ± 0.18 6 months after the onset of treatment with bDMARDs, denoting significant improvement of the participants' QOL. All the investigated types of disease exhibited significant improvement at the 6-month assessment, without any difference among them (p = 0.965). The participants with baseline poorest functionality and best QOL exhibited the best QOL outcomes after 6 months of treatment. Our study showed that the use of biological drugs induced considerable improvement in the participants' QOL.

  15. HIV Risk Behavior of Runaway Youth in San Francisco: Age of Onset and Relation to Sexual Orientation.

    Science.gov (United States)

    Moon, Martha W.; McFarland, William; Kellogg, Timothy; Baxter, Michael; Katz, Mitchell H.; MacKellar, Duncan; Valleroy, Linda A.

    2000-01-01

    Examined HIV risk behaviors among runaway youth by age at onset and sexual orientation. Adolescents age 12-21 years seeking health care at two clinics completed interviews and blood testing. Gay/lesbian/bisexual youth reported higher levels and earlier onset of sexual and drug-using behavior than heterosexual youth and were at exceptionally high…

  16. Work-related psychosocial factors and onset of metabolic syndrome among workers: a systematic review and meta-analysis protocol.

    Science.gov (United States)

    Sakuraya, Asuka; Watanabe, Kazuhiro; Kawakami, Norito; Imamura, Kotaro; Ando, Emiko; Asai, Yumi; Eguchi, Hisashi; Kobayashi, Yuka; Nishida, Norimitsu; Arima, Hideaki; Shimazu, Akihito; Tsutsumi, Akizumi

    2017-06-22

    Metabolic syndrome is an important public health target because of its high prevalence worldwide. Work-related psychosocial factors have been identified as determinants of metabolic syndrome components. However, there have been no systematic reviews or meta-analyses conducted to evaluate the relationship between work-related psychosocial factors and metabolic syndrome as an aggregated cluster. The aim of this study is to examine this association from published prospective studies. The systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, PsycINFO, PsycARTICLES and Japan Medical Abstracts Society). Studies that (1) examined the association between work-related psychosocial factors and the onset of metabolic syndrome, (2) had a longitudinal or prospective cohort design, (3) were conducted among workers, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) were published as original articles written in English or Japanese, and (6) having been published until the end of 2016 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators. Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in the workplace, and determining approaches for prevention of metabolic syndrome in the future. PROSPERO CRD42016039096 (http://www.crd.york.ac.uk/PROSPERO_REBRANDING/display_record.asp?ID=CRD42016039096). © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  17. Impact of endocrine disrupting chemicals on onset and development of female reproductive disorders and hormone-related cancer.

    Science.gov (United States)

    Scsukova, Sona; Rollerova, Eva; Bujnakova Mlynarcikova, Alzbeta

    2016-12-01

    A growing body of evidence suggests that exposure to chemical substances designated as endocrine disrupting chemicals (EDCs) due to their ability to disturb endocrine (hormonal) activity in humans and animals, may contribute to problems with fertility, pregnancy, and other aspects of reproduction. The presence of EDCs has already been associated with reproductive malfunction in wildlife species, but it remains difficult to prove causal relationships between the presence of EDCs and specific reproductive problems in vivo, especially in females. On the other hand, the increasing number of experiments with laboratory animals and in vitro research indicate the ability of different EDCs to influence the normal function of female reproductive system, and even their association with cancer development or progression. Research shows that EDCs may pose the greatest risk during prenatal and early postnatal development when organ and neural systems are forming. In this review article, we aim to point out a possible contribution of EDCs to the onset and development of female reproductive disorders and endocrine-related cancers with regard to the period of exposure to EDCs and affected endpoints (organs or processes).

  18. L'homme dans les soins: sa relation avec les patients féminins : travail de Bachelor

    OpenAIRE

    Walker, Zena; Delétraz, Damien; Badoux, Claudine

    2014-01-01

    Le genre est un aspect omniprésent dans toute relation interpersonnelle, mais les enjeux y relatifs sont d’autant plus importants dans l’univers des soins et à fortiori dans la profession infirmière. En effet, du fait de l’intimité que les soins peuvent présenter, le sexe autant du soignant que du patient peut donner lieu à des aspects relationnels positifs et négatifs. Cette recherche a pour but de mettre en évidence ces différents aspects en traitant plusieurs thématiques comme la communica...

  19. Do online assessed self-report and behavioral measures of impulsivity-related constructs predict onset of substance use in adolescents?

    Directory of Open Access Journals (Sweden)

    Tim Janssen

    2015-06-01

    Conclusions: Based on the present results, the added value of online behavioral assessment of impulsivity-related factors in the prediction of onset of substance use was not confirmed. We suggest that factors specific to each behavioral task underlie their lack of prediction and suggest that future research addresses limitations of current behavioral tasks to increase their validity in online testing.

  20. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients

    DEFF Research Database (Denmark)

    Metzger, Silke; Walter, Carolin; Riess, Olaf;

    2013-01-01

    , we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second...

  1. Late-Onset Drug-Induced Cholestasis in a Living-Related Liver Transplant Donor With Progressive Familial Intrahepatic Cholestasis.

    Science.gov (United States)

    Harmancı, Özgür; Ensaroğlu, Fatih; Özçay, Figen; Öcal, Serkan; Korkmaz, Murat; Özdemir, B Handan; Selçuk, Haldun; Moray, Gökhan; Haberal, Mehmet

    2015-11-01

    We present a rare case of progressive familial intrahepatic cholestasis within a family. A 34-yearold female became a living-related liver transplant donor for her son, who had the disease. Nine years after the transplant, the mother developed severe intrahepatic cholestasis, for which she was evaluated after using an oral contraceptive drug. She presented with jaundice, pruritus, and increased bilirubin levels, together with elevated gamma glutamyl transferase and alkaline phosphatase levels. A liver biopsy revealed findings consistent with intrahepatic cholestasis. However, despite follow-up management and cessation of the insulting drug, her total bilirubin count continuously increased to 20 mg/dL and was accompanied by intractable pruritus. A total of 9 plasmapheresis sessions were performed, and she was started on a regimen of ursodeoxycholic acid (13 mg/kg/d) and cholestyramine (4 g, 3 times daily). The clinical and laboratory picture dramatically improved following cessation of the oral contraceptive, plasmapheresis sessions, and drug treatment. The patient's cholestasis normalized within 3 months, and she recovered uneventfully. A genetic analysis of the whole family revealed that both parents were heterozygous for the mutation c.124G>A in ABCB11, and the son was homozygous for this mutation. These findings supported varying degrees of bile salt export pump deficiency in the family members. Defective bile salt excretory system function can result in a wide spectrum of clinical presentations, ranging from progressive familial intrahepatic cholestasis requiring liver transplant to late-onset drug-induced cholestasis. Our findings suggest that, in a heterozygous carrier of a progressive familial intrahepatic cholestasis mutation, drug-induced cholestasis is responsive to treatment, after which the clinical picture can normalize within 3 months.

  2. A relação médico-paciente no contexto da saúde como produto The doctor-patient relation in the context of health seen as a product

    Directory of Open Access Journals (Sweden)

    Gabriel Bergmann Borges Vieira

    2010-11-01

    Full Text Available O presente artigo propõe uma revisão teórica da relação médico-paciente no contexto da saúde como produto sociocultural da pós-modernidade. Foi realizada busca na Internet nos bancos de dados PubMed, Lilacs e Biblioteca Cochrane com as palavras-chave: relação médico-paciente, saúde, produto e pós-modernidade. Livros textos de Medicina e também obras referenciais de Filosofia, Sociologia e Marketing foram consultadas. A relação médico-paciente foi analisada a partir da conceituação de saúde e produto. Assim, ao considerar-se a saúde como produto da sociedade de consumo, discutiu-se as modificações ocorridas no atendimento médico; nas relações entre o profissional da saúde (médico e o paciente (cliente.This article presents a theoretical review of the doctor-patient relation in the context of health as a socio-cultural product of postmodernity. We searched the data bases Pub Med, Lilacs and the Cochrane Library in the Internet, using the key words doctor-patient relation, health, product and post-modernity. We also searched medical textbooks as well as reference works in the fields of philosophy, sociology and marketing. The doctor-patient relation was analyzed based on the concepts health and product. Thus, by considering health a product of the consumer society, one discussed the changes that occurred in medical care and in the relation between the health professional (doctor and the patient (client.

  3. A qualitative analysis of factors related to eating disorder onset in female collegiate athletes and non-athletes.

    Science.gov (United States)

    Arthur-Cameselle, Jessyca; Sossin, Kayla; Quatromoni, Paula

    2016-11-29

    Female athletes are at risk for clinical eating disorders, yet their onset experiences have rarely been studied with qualitative methods. This study, which included interviews with 12 collegiate female athletes and 17 non-athletes, identified factors that contributed to eating disorder onset for both subgroups. Inductive content analysis revealed that low self-worth, peer issues, and comorbid psychological disorders were common in both groups. However, athletes reported sport-specific factors including performance pressure, team weigh-ins, and injuries, whereas family dysfunction, bullying, and puberty were more commonly reported triggers for non-athletes. Findings support prevention and treatment programs customized for unique vulnerabilities for each subgroup.

  4. Um estudo comparativo de dois serviços de saúde mental: relações entre participação popular e representações sociais relacionadas ao direito à saúde A comparative study of two mental health services: relationships between popular participation and social representations related to the right to health

    Directory of Open Access Journals (Sweden)

    Cláudio Luis da Cunha Gastal

    2007-08-01

    Full Text Available Este artigo origina-se de uma pesquisa qualitativa que analisou representações sociais relacionadas ao direito à saúde de usuários de dois serviços de saúde mental: um constituído e funcionando com participação de usuários e familiares e outro sem essa participação, visando conhecê-las não apenas vinculadas à consciência do direito à saúde, mas também a fatores associados, como: participação popular, o processo de adoecimento; o atendimento público de saúde, percepção da capacidade de intervenção social, e concepções sobre o Estado. As representações sociais encontradas associadas ao direito à saúde implicam expectativas de que o sistema de saúde e o Estado cumpram funções de acolhimento e amparo. Os usuários do serviço sem participação popular tendem a ser mais conformados e pessimistas. O grupo com participação popular vê o serviço que construiu como possuidor das características negadas pelo sistema oficial e percebe como possível a ação reivindicativa, podendo ser um foco alternativo na formação de novas representações sociais.The present paper originated from a qualitative study that analyzed social representations related to the right to health, expressed by users of two types of mental health services, one with participation by users and families and the other without such participation. The aim was to analyze such representations not only in relation to the awareness of the right to health, but also concerning associated factors, such as: popular participation; illness; public health care; perception of social intervention capacity; and concepts concerning the state. Social representations of the right to health involve expectations that the health system and the state meet their roles of ensuring care and support. Users of the mental health service without user/family participation tended to be more resigned and pessimistic. The group with participation views the service it has built

  5. Validation of the bipolar disorder etiology scale based on psychological behaviorism theory and factors related to the onset of bipolar disorder.

    Directory of Open Access Journals (Sweden)

    Jae Woo Park

    Full Text Available OBJECTIVES: The aim of this study was to identify psychosocial factors related to the onset of bipolar I disorder (BD. To do so, the Bipolar Disorder Etiology Scale (BDES, based on psychological behaviorism, was developed and validated. Using the BDES, common factors related to both major depressive disorder (MDD and BD and specific factors related only to BD were investigated. METHOD: The BDES, which measures 17 factors based on psychological behaviorism hypotheses, was developed and validated. This scale was administered to 113 non-clinical control subjects, 30 subjects with MDD, and 32 people with BD. ANOVA and post hoc analyses were conducted. Subscales on which MDD and BD groups scored higher than controls were classified as common factors, while those on which the BD group scored higher than MDD and control groups were classified as specific factors. RESULTS: The BDES has acceptable reliability and validity. Twelve common factors influence both MDD and BD and one specific factor influences only BD. Common factors include the following: learning grandiose self-labeling, learning dangerous behavior, reinforcing impulsive behavior, exposure to irritability, punishment of negative emotional expression, lack of support, sleep problems, antidepressant problems, positive arousal to threat, lack of social skills, and pursuit of short-term pleasure. The specific factor is manic emotional response. CONCLUSIONS: Manic emotional response was identified as a specific factor related to the onset of BD, while parents' grandiose labeling is a candidate for a specific factor. Many factors are related to the onset of both MDD and BD.

  6. Validation of the bipolar disorder etiology scale based on psychological behaviorism theory and factors related to the onset of bipolar disorder.

    Science.gov (United States)

    Park, Jae Woo; Park, Kee Hwan

    2014-01-01

    The aim of this study was to identify psychosocial factors related to the onset of bipolar I disorder (BD). To do so, the Bipolar Disorder Etiology Scale (BDES), based on psychological behaviorism, was developed and validated. Using the BDES, common factors related to both major depressive disorder (MDD) and BD and specific factors related only to BD were investigated. The BDES, which measures 17 factors based on psychological behaviorism hypotheses, was developed and validated. This scale was administered to 113 non-clinical control subjects, 30 subjects with MDD, and 32 people with BD. ANOVA and post hoc analyses were conducted. Subscales on which MDD and BD groups scored higher than controls were classified as common factors, while those on which the BD group scored higher than MDD and control groups were classified as specific factors. The BDES has acceptable reliability and validity. Twelve common factors influence both MDD and BD and one specific factor influences only BD. Common factors include the following: learning grandiose self-labeling, learning dangerous behavior, reinforcing impulsive behavior, exposure to irritability, punishment of negative emotional expression, lack of support, sleep problems, antidepressant problems, positive arousal to threat, lack of social skills, and pursuit of short-term pleasure. The specific factor is manic emotional response. Manic emotional response was identified as a specific factor related to the onset of BD, while parents' grandiose labeling is a candidate for a specific factor. Many factors are related to the onset of both MDD and BD.

  7. Relation between EDSS and monosymptomatic or polysymptomatic onset in clinical manifestations of multiple sclerosis in Babol, northern Iran.

    Science.gov (United States)

    Hojjati, Seyed Mohammad Masood; Hojjati, Seyyed Ali; Baes, Mobina; Bijani, Ali

    2014-01-01

    Polysymptomatic or monosymptomatic patients of multiple sclerosis (MS) at the onset of the disease may influence the natural course of the disease. The purpose of this study was to determine the prognostic effect of the expanded disability status scale (EDSS) of patients with MS with polysymptomatic or monosymptomatic onset of the disease. From 2001 to 2011, 263 patients with definitive diagnosis of MS were investigated in Shahid Beheshti Teaching Hospital in Babol, Iran. These patients were assessed regarding mono-or poly symptoms at the beginning of their disease. MRI of brain and spinal cord was done for all cases. These cases were evaluated every three months interval. EDSS of each patient at the beginning of their disease and then yearly were evaluated and registered. One hundred sixty-one subjects (61.2%) were monosymptomatic and 102 (38.8%) were polysymptomatic at the onset of their disease. The mean age of patients with monosymptomatic onset was 26.81+84 while in polysymptomatic was 26.35+7.7 years (P=0.656). Sex, place of residence and marriage statusbetween these two groups were equal. The mean EDSS in monosymptomatic and polysymptomatic patients were 1.37±0.64 and 2.16±0.714, respectively (P=0.0001). After the initiation of treatment, reduction of EDSS was seen in both groups but after the reduction in the first year, an increase of EDSS was seen in both groups. But there was no significant difference in the increase of EDSS in both groups. The results showed that the mean EDSS in monosymptomatic was lower than the polysymptomatic patients before treatment, but after treatment, this value does not differ in the increase of EDSS.

  8. Health SA Gesondheid

    African Journals Online (AJOL)

    Health SA Gesondheid - Journal of Interdisciplinary Health Sciences is an open access, .... Chokwe M. Setati, Zerish Z. Nkosi, 130-137 ... Movement as a critical concept in model generation to attain wholeness · EMAIL FREE FULL TEXT ...

  9. Variability of the date of monsoon onset over Kerala (India) of the period 1870-2014 and its relation to sea surface temperature

    Science.gov (United States)

    Preenu, P. N.; Joseph, P. V.; Dineshkumar, P. K.

    2017-07-01

    Monsoon onset over Kerala (India) which occurs every year is a major climatic phenomenon that involves large scale changes in wind, rainfall and sea surface temperature (SST). Over the last 150 years, the date of monsoon onset over Kerala (DMOK) has varied widely, the earliest being 11 May, 1918 and the most delayed being 18 June, 1972. DMOK has a long term (1870-2014) mean of 01 June and standard deviation of 7-8 days. We have studied the inter-annual and decadal time scale variability of DMOK and their relation with SST. We found that SST anomalies of large spatial scale similar to those in El Nino/La Nina are associated with the inter-annual variability in DMOK. Indian Ocean between latitudes 5°S and 20°N has two episodes of active convection associated with monsoon onset over Kerala (MOK), one around DMOK and the other about six weeks earlier (called pre-monsoon rain peak or bogus monsoon onset) and in between a two week period of suppressed convection occurs over north Indian Ocean. A prominent decadal time scale variability was found in DMOK having large and statistically significant linear correlation with the SST gradient across the equator over Indian and Pacific oceans, the large correlation persisting for several months prior to the MOK. However, no linear trend was seen in DMOK during the long period from 1870 to 2014.

  10. Variability of the date of monsoon onset over Kerala (India) of the period 1870–2014 and its relation to sea surface temperature

    Indian Academy of Sciences (India)

    P N Preenu; P V Joseph; P K Dineshkumar

    2017-07-01

    Monsoon onset over Kerala (India) which occurs every year is a major climatic phenomenon that involves large scale changes in wind, rainfall and sea surface temperature (SST). Over the last 150 years, the date of monsoon onset over Kerala (DMOK) has varied widely, the earliest being 11 May, 1918 and the most delayed being 18 June, 1972. DMOK has a long term (1870–2014) mean of 01 June and standard deviation of 7–8 days. We have studied the inter-annual and decadal time scale variability of DMOK and their relation with SST. We found that SST anomalies of large spatial scale similar to those in El Nino/La Nina are associated with the inter-annual variability in DMOK. Indian Ocean between latitudes 5∘S and 20∘N has two episodes of active convection associated with monsoon onset over Kerala (MOK), one around DMOK and the other about six weeks earlier (called pre-monsoon rain peak or bogus monsoon onset) and in between a two week period of suppressed convection occurs over north Indian Ocean. A prominent decadal time scale variability was found in DMOK having large and statistically significant linear correlation with the SST gradient across the equator over Indian and Pacific oceans, the large correlation persisting for several months prior to the MOK. However, no linear trend was seen in DMOK during the long period from 1870 to 2014.

  11. SalSA status

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Amy [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)], E-mail: amyc@hep.ucl.ac.uk

    2009-06-01

    I review the status of SalSA, a proposed antenna array in a large volume salt formation for detecting ultra-high energy neutrinos. We report on measurements taken in 2007 of attenuation lengths in the 125-900 MHz frequency range at the Cote Blanche salt mine near New Iberia, Louisiana, which is the most precise in situ measurement of attenuation lengths in salt to date. We comment on the impact of these measurements on the feasibility of SalSA.

  12. Humanização das práticas do profissional de saúde: contribuições para reflexão Thinking about health related professions humanizated practice

    Directory of Open Access Journals (Sweden)

    Bárbara Niegia Garcia de Goulart

    2010-01-01

    Full Text Available Este artigo se propõe a contribuir com subsídios para a reflexão da atuação clínica contemporânea sob a ótica da humanização da atenção à saúde a partir de revisão da literatura indexada e publicada no Brasil nas bases de dados da biblioteca virtual em saúde (BVS e Scielo entre 1987 e 2007, bem como autores citados nestes estudos e publicados no mesmo período, quando considerado essencial para consubstanciar as discussões apresentadas. Também são discutidas questões ligadas à humanização da saúde a partir da concepção da humanização como política de saúde e como prática profissional, assim como possibilidades de ampliação da discussão da necessidade de incorporar tais premissas nas diversas etapas da formação dos alunos de graduação no que concerne ao tema. Além disso, são apresentadas proposições para contribuir à formação do profissional ligado ao setor saúde desde a graduação, bem como subsídios para a reflexão sobre as propostas curriculares e oportunidades oferecidas pelos professores universitários, os quais podem influir fortemente na formação profissional e, posteriormente, com o funcionamento e com as práticas vigentes nos serviços de saúde.This article intends to contribute with some reflections about contemporary clinical approach concerning humanized health assistance based on the review of literature indexed and published in Brazil at BVS and Scielo between 1987 and 2007, including some authors referred in these studies and published in the same period, when considered essential to consubstantiate the discussions presented. Matters are also discussed regarding humanized health care based on public policies and health related professional practices, as well as the possibilities for extending discussions related to the need of inclusion of theses principles in various stages of the health professional background, from undergraduate studies. In addition, some propositions are

  13. The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients.

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    Silke Metzger

    Full Text Available The cause of Huntington disease (HD is a polyglutamine repeat expansion of more than 36 units in the huntingtin protein, which is inversely correlated with the age at onset of the disease. However, additional genetic factors are believed to modify the course and the age at onset of HD. Recently, we identified the V471A polymorphism in the autophagy-related gene ATG7, a key component of the autophagy pathway that plays an important role in HD pathogenesis, to be associated with the age at onset in a large group of European Huntington disease patients. To confirm this association in a second independent patient cohort, we analysed the ATG7 V471A polymorphism in additional 1,464 European HD patients of the "REGISTRY" cohort from the European Huntington Disease Network (EHDN. In the entire REGISTRY cohort we could not confirm a modifying effect of the ATG7 V471A polymorphism. However, analysing a modifying effect of ATG7 in these REGISTRY patients and in patients of our previous HD cohort according to their ethnic origin, we identified a significant effect of the ATG7 V471A polymorphism on the HD age at onset only in the Italian population (327 patients. In these Italian patients, the polymorphism is associated with a 6-years earlier disease onset and thus seems to have an aggravating effect. We could specify the role of ATG7 as a genetic modifier for HD particularly in the Italian population. This result affirms the modifying influence of the autophagic pathway on the course of HD, but also suggests population-specific modifying mechanisms in HD pathogenesis.

  14. Psycho-organic symptoms as early manifestation of adult onset POMT1-related limb girdle muscular dystrophy.

    Science.gov (United States)

    Haberlova, J; Mitrović, Z; Zarković, K; Lovrić, D; Barić, V; Berlengi, L; Bilić, K; Fumić, K; Kranz, K; Huebner, A; von der Hagen, M; Barresi, R; Bushby, K; Straub, V; Barić, I; Lochmüller, H

    2014-11-01

    We report two siblings of Croatian consanguineous healthy parents with a novel homozygous missense mutation in the POMT1 gene, presenting with intellectual disability and psychotic, in particular hallucinatory symptoms and abnormal brain MRIs, preceding classical symptoms of limb-girdle muscular dystrophy by several years. Weakness became apparent in early adulthood and both siblings remained ambulant into the 3rd and 4th decade of life. The muscle biopsy showed reduced α-dystroglycan compatible with the POMT1 defect. This case report extends the phenotypic spectrum of POMT1 associated muscular dystrophies to the adult onset limb girdle muscular dystrophies with psycho-organic deficits.

  15. Onset dominance in lateralization.

    Science.gov (United States)

    Freyman, R L; Zurek, P M; Balakrishnan, U; Chiang, Y C

    1997-03-01

    Saberi and Perrott [Acustica 81, 272-275 (1995)] found that the in-head lateralization of a relatively long-duration pulse train could be controlled by the interaural delay of the single pulse pair that occurs at onset. The present study examined this further, using an acoustic pointer measure of lateralization, with stimulus manipulations designed to determine conditions under which lateralization was consistent with the interaural onset delay. The present stimuli were wideband pulse trains, noise-burst trains, and inharmonic complexes, 250 ms in duration, chosen for the ease with which interaural delays and correlations of select temporal segments of the stimulus could be manipulated. The stimulus factors studied were the periodicity of the ongoing part of the signal as well as the multiplicity and ambiguity of interaural delays. The results, in general, showed that the interaural onset delay controlled lateralization when the steady state binaural cues were relatively weak, either because the spectral components were only sparsely distributed across frequency or because the interaural time delays were ambiguous. Onset dominance can be disrupted by sudden stimulus changes within the train, and several examples of such changes are described. Individual subjects showed strong left-right asymmetries in onset effectiveness. The results have implications for understanding how onset and ongoing interaural delay cues contribute to the location estimates formed by the binaural auditory system.

  16. Serum Levels of Toxic AGEs (TAGE May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases

    Directory of Open Access Journals (Sweden)

    Masayoshi Takeuchi

    2016-06-01

    Full Text Available Advanced glycation end-products (AGEs generated with aging or in the presence of diabetes mellitus, particularly AGEs derived from the glucose/fructose metabolism intermediate glyceraldehyde (Glycer-AGEs; termed toxic AGEs (TAGE, were recently shown to be closely involved in the onset/progression of diabetic vascular complications via the receptor for AGEs (RAGE. TAGE also contribute to various diseases, such as cardiovascular disease; nonalcoholic steatohepatitis; cancer; Alzheimer’s disease, and; infertility. This suggests the necessity of minimizing the influence of the TAGE-RAGE axis in order to prevent the onset/progression of lifestyle-related diseases (LSRD and establish therapeutic strategies. Changes in serum TAGE levels are closely associated with LSRD related to overeating, a lack of exercise, or excessive ingestion of sugars/dietary AGEs. We also showed that serum TAGE levels, but not those of hemoglobin A1c, glucose-derived AGEs, or Nε-(carboxymethyllysine, have potential as a biomarker for predicting the progression of atherosclerosis and future cardiovascular events. We herein introduce the usefulness of serum TAGE levels as a biomarker for the prevention/early diagnosis of LSRD and the evaluation of the efficacy of treatments; we discuss whether dietary AGE/sugar intake restrictions reduce the generation/accumulation of TAGE, thereby preventing the onset/progression of LSRD.

  17. An age-related reduction of brain TBPH/TDP-43 levels precedes the onset of locomotion defects in a Drosophila ALS model.

    Science.gov (United States)

    Cragnaz, L; Klima, R; De Conti, L; Romano, G; Feiguin, F; Buratti, E; Baralle, M; Baralle, F E

    2015-12-17

    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. The average age of onset of both sporadic and familial cases is 50-60 years of age. The presence of cytoplasmic inclusions of the RNA-binding protein TAR DNA-binding protein-43 (TDP-43) in the affected neurons is seen in 95% of the ALS cases, which results in TDP-43 nuclear clearance and loss of function. The Drosophila melanogaster ortholog of TDP-43 (TBPH) shares many characteristics with the human protein. Using a TDP-43 aggregation inducer previously developed in human cells, we created a transgenic fly that shows an adult locomotive defect. Phenotype onset correlates with a physiologically age-related drop of TDP-43/TBPH mRNA and protein levels, seen both in mice and flies. Artificial reduction of mRNA levels, in vivo, anticipates the locomotion defect to the larval stage. Our study links, for the first time, aggregation and the age-related, evolutionary conserved reduction of TDP-43/TBPH levels with the onset of an ALS-like locomotion defect in a Drosophila model. A similar process might trigger the human disease. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Is postpartum depression a homogenous disorder: time of onset, severity, symptoms and hopelessness in relation to the course of depression.

    Science.gov (United States)

    Kettunen, Pirjo; Koistinen, Eeva; Hintikka, Jukka

    2014-12-10

    Postpartum depression (PPD) is a common illness, but due to the underlying processes and the diversity of symptoms, some variability is exhibited. The risk of postpartum depression is great if the mother has previously suffered from depression, but there is some evidence that a certain subgroup of women only experience depression during the postpartum period. The study group consisted of 104 mothers with postpartum major depression and a control group of 104 postpartum mothers without depression. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) was used for data collection. The severity of depression and other mental symptoms were assessed using several validated rating scales. A history of past depression (82%), including depression during pregnancy (42%) and during the postpartum period (53%), was very common in those with current PPD. Eighteen per cent of mothers with current PPD had previously not had any depressive episodes and four per cent had experienced depression only during the postpartum period. Therefore, pure PPD was rare. The onset of PPD was usually (84%) within six weeks of childbirth. Obsessive-compulsive symptoms, phobic anxiety, paranoid ideation, depressed mood, diminished pleasure/interest, decreased energy, and psychomotor agitation/retardation were common with all kinds of depression histories. Pure PPD was the most similar to the first depressive episode. Nevertheless, the severity of depression, the level of hopelessness, somatisation, interpersonal sensitivity, anxiety, hostility, psychoticism, sleep disturbance, and suicidal ideation were lower, appetite changed less, and concentration was better than in other recurrent depressions. According to this study, PPD is not a homogenous disorder. The time of onset, severity, symptoms, level of hopelessness, and the course of depression vary. Recurrent depression is common. All mothers must be screened during the sixth week postpartum at the latest. Screening alone is not

  19. Is the onset of the 6th century 'dark age' in Maya history related to explosive volcanism?

    Science.gov (United States)

    Nooren, Kees; Hoek, Wim Z.; Van der Plicht, Hans; Sigl, Michael; Galop, Didier; Torrescano-Valle, Nuria; Islebe, Gerald; Huizinga, Annika; Winkels, Tim; Middelkoop, Hans; Van Bergen, Manfred

    2016-04-01

    Maya societies in Southern Mexico, Guatemala and Belize experienced a 'dark age' during the second half of the 6th century. This period, also known as the 'Maya Hiatus', is characterized by cultural downturn, political instability and abandonment of many sites in the Central Maya Lowlands. Many theories have been postulated to explain the occurrence of this 'dark age' in Maya history. A possible key role of a large volcanic eruption in the onset of this 'dark age' will be discussed. Volcanic deposits recovered from the sedimentary archive of lake Tuspán and the Usumacinta-Grijalva delta were studied in detail and the combination of multiple dating techniques allowed the reconstruction of the timing of a large 6th century eruption. Volcanic glass shards were fingerprinted to indicate the source volcano and high resolution pollen records were constructed to indicate the environmental impact of the eruption. Results are compared with available archaeological data and causality with the disruption of Maya civilization will be evaluated.

  20. Can the higher risk of disability onset among older people who live alone be alleviated by strong social relations? A longitudinal study of non-disabled men and women

    DEFF Research Database (Denmark)

    Lund, Rikke; Nilsson, Charlotte Juul; Avlund, Kirsten

    2010-01-01

    with onset of disability for both genders. Among men who lived alone low social participation was a significant predictor of disability onset [odds ratio, OR = 2.30 (1.00-5.29)]; for cohabiting men social participation was not associated with disability onset, [adjusted OR = 0.91 (0.49-1.71)]. Similar...... results were present concerning satisfaction with the social relations among men. There was no significant interaction for women. CONCLUSIONS: the study suggests that men who live alone can possibly alleviate their risk of disability onset by being socially active and by having access to satisfactory......PURPOSE: to investigate if the increased risk of disability onset among older people who live alone could possibly be moderated by either high social participation or by being satisfied with the social relations. DESIGN AND METHODS: logistic regression models were tested using two waves in a study...

  1. Impact of birth weight on adult-onset diabetes mellitus in relation to current body mass index: The Japan Nurses' Health Study.

    Science.gov (United States)

    Katanoda, Kota; Noda, Mitsuhiko; Goto, Atsushi; Mizunuma, Hideki; Lee, Jung Su; Hayashi, Kunihiko

    2017-09-01

    Although birth weight is considered as a fetal determinant of the development of adult-onset diabetes mellitus (DM), its public health importance relative to adult body mass index (BMI) remains unclear. We aimed to examine the association between adult-onset DM and birth weight in relation to adult BMI. We conducted a self-administered questionnaire as a baseline survey of the Japanese Nurses' Health Study cohort between 2001 and 2007. Exclusion criteria were applied to the volunteer sample of 49,927 female nurses (age <30 years or unknown, current pregnancy, development of DM before the age of 30 years, unknown core variables), and data from 26,949 female nurses aged 30 years or older were used. The association between history of DM diagnosis and birth weight was analyzed using logistic regression. A linear inverse association was observed between birth weight and DM, after adjustment for age, BMI, and parental history of DM. The odds ratio for developing DM per 100 g increase in birth weight was 0.93 (95% confidence interval [CI], 0.90-0.96). The association was unchanged when birth weight was converted to percentile for gestational age. In the BMI-stratified analysis, the odds ratio for DM in the <2500 g birth weight group reached 4.75 (95% CI, 1.22-18.44, compared to the reference 3000-3499 g group) among women with normal low BMI (18.5-20.9). Birth weight and its percentile for gestational age were associated with adult-onset DM. Attention should be paid to the risk of DM among women born with low weight, even when their current BMI is normal. Copyright © 2017 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  2. Relationship between health-related quality of life, disease activity and disease damage in a prospective international multicenter cohort of childhood onset systemic lupus erythematosus patients

    DEFF Research Database (Denmark)

    Moorthy, L N; Baldino, M E; Kurra, V;

    2017-01-01

    Previously, we described associations between health-related quality of life (HRQOL) and disease-related factors among childhood onset systemic lupus erythematosus (cSLE) patients. Here we determined the relationship between HRQOL, disease activity and damage in a large prospective international...... cohort of cSLE. We compared HRQOL, disease activity and disease damage across different continents and examined the relationship between children's and parents' assessments of HRQOL. Patients with cSLE and their parents completed HRQOL measures at enrollment and ≥4 follow-up visits. Physicians assessed...... disease activity and damage. The multinational cohort ( n = 467) had relatively low disease activity and damage. Patient and parent HRQOL scores were significantly correlated. Asian and European patients had the highest HRQOL, while South and North American patients had lower HRQOL scores. Renal, CNS...

  3. A relação entre o espaço e a saúde bucal coletiva: por uma epidemiologia georreferenciada The relation between space and collective oral health: for a georeferenced epidemiology

    Directory of Open Access Journals (Sweden)

    Rafael da Silveira Moreira

    2007-03-01

    Full Text Available A importância do meio-ambiente sobre a saúde das pessoas é uma preocupação antiga do ser humano. Dos textos hipocráticos aos dias de hoje, o conceito de espaço permitiu e permite diferentes representações e formas de apreensão. Superando a concepção natural do espaço apenas como um ambiente inerte e passivo, a visão de um espaço geográfico socialmente construído, tanto como um receptor dos processos sociais quanto como o próprio ativador destes processos, torna-se cada vez mais relevante na compreensão dos fenômenos envolvidos no processo saúde-doença. Neste sentido, a epidemiologia se apresenta como um referencial privilegiado na articulação entre os elementos lugar-tempo-pessoas. Este ensaio reflexivo busca explorar as relações estabelecidas entre o espaço (social e geográfico e a Saúde Bucal Coletiva, destacando o papel do território na reprodução das iniqüidades em saúde e a necessidade do desenvolvimento de pesquisas que abordem o espaço como elemento constitutivo do processo saúde-doença bucal. Aproximando-se do que poderia ser chamado de uma epidemiologia georreferenciada, a expressão espacial dos eventos de saúde-doença bucal e dos atores envolvidos neste processo fortalece a importância do território (e suas várias significações para a Saúde Bucal Coletiva.The influence of the environment on health is an ancient human concern. From the Hippocratic texts to today, the concept of space permitted and still permits different representations and forms of perception. Overcoming the natural conception of space as only an inert and passive environment, the idea of a socially constructed geographic space, both as a receiver of social processes as much as being its own activator in these processes, becomes ever more relevant in the comprehension of phenomena involved in the health-disease process. In this sense, epidemiology is presented as a privileged reference point in the articulation of place

  4. Empowerment como forma de prevenção de problemas de saúde em trabalhadores de abatedouros Empowerment as a way to prevent work-related health conditions in slaughterhouse workers

    Directory of Open Access Journals (Sweden)

    Paula Tavolaro

    2007-04-01

    Full Text Available O objetivo do artigo foi ressaltar a necessidade de esforços educativos que visem ao empowerment de funcionários de abatedouros, baseado nos principais problemas de saúde por eles enfrentados. A rotina em abatedouros consiste em tarefas estressantes e cansativas. As conseqüências incluem problemas músculo-esqueléticos, transmissão de zoonoses, problemas de pele e acidentes com materiais pérfuro-cortantes e animais. Esses trabalhadores geralmente não são especializados, não têm controle sobre suas tarefas, e podem não estar conscientes dos determinantes que afetam sua saúde. Os veterinários são geralmente responsáveis pela rotina de trabalho nesses locais e conhecem os riscos à saúde que a execução dessas tarefas representam. Portanto, esses profissionais poderiam participar mais ativamente na educação para o empowerment dos trabalhadores e não se concentrarem apenas em questões referentes à segurança alimentar.The objective of the review was to emphasize the need for educational efforts aiming at the empowerment of slaughterhouse workers based on their major work-related conditions. Slaughterhouse work involves stressful and tiring tasks. These workers suffer from serious occupational injuries and health problems including musculoskeletal disorders, zoonoses, skin conditions and injuries related to animals and sharp instruments. Slaughterhouse workers are generally low-skill staff, have no control over their job tasks and may not be aware of the determinants affecting their health. While working for the Brazilian Ministry of Agriculture, veterinarians are greatly responsible for the work routine in slaughterhouses and are aware of health risks involved in these workers' job. Besides focusing their activities on food safety, veterinarians they should take an active role in educating slaughterhouse workers for their empowerment.

  5. Considerations on methodology used in the World Health Organization 2000 Report Considerações Metodológicas sobre o Relatório 2000 da Organização Mundial de Saúde

    Directory of Open Access Journals (Sweden)

    Alicia Domingues Ugá

    2001-06-01

    Full Text Available The article analyzes the World Health Organization Report for 2000, with emphasis placed on the methodology used to analyze the indicators utilized to compare and classify the performance of the health systems of the 191 member countries. The Report's contribution was the compromise of monitoring the performance of the health systems of member countries, but because of the inconsistent way it was elaborated, and the utilization of questionable scientific evaluation methodologies, the Report fails to give a clear picture. A criterion-based methodology revision is imposed. The main problems in evidence are the choice of individual indicators of disparity in health that discount the population profile, the inadequate control of the impact of social disparities over the performance of the systems, the evaluation of the responsibility of systems that are only partially articulated to the right of the citizens, the lack of data for a great number of countries, consequently having inconsistent estimations, and the lack of transparency in the methodological procedures in the calculation of some indicators. The article suggests a wide methodological revision of the Report.O artigo discute o Relatório da Organização Mundial de Saúde para 2000, com ênfase na análise metodológica dos indicadores utilizados para comparar e classificar o desempenho dos sistemas de saúde dos 191 países membros. O Relatório contribui ao colocar na agenda o compromisso de monitorar o desempenho dos sistemas de saúde dos países membros porém, a forma inconsistente de sua elaboração e a utilização de metodologias de avaliação questionáveis cientificamente, impõem uma criteriosa revisão metodológica. Os principais problemas destacados são a escolha de indicadores individuais de desigualdade em saúde que desconsideram o perfil populacional; o controle inadequado do impacto das desigualdades sociais sobre o desempenho dos sistemas; a avaliação da

  6. O papel necessário da Agência Nacional de Saúde Suplementar na regulação das relações entre operadoras de planos de saúde e prestadores de serviços The necessary role of the National Supplementary Health Agency in the regulation of relations between managed care companies and service providers

    Directory of Open Access Journals (Sweden)

    Silvia Gerschman

    2012-06-01

    Full Text Available Este artigo trata do papel regulatório que caberia à Agência Nacional de Saúde Suplementar (ANS desempenhar, a partir do resultado de um conjunto de pesquisas e estudos sobre as práticas de microrregulação exercidas pelas operadoras de planos de saúde sobre os prestadores hospitalares privados. O trabalho se baseia em diversos estudos e, especialmente, nos resultados da pesquisa de Ugá et al. (2007, cujos resultados permitiram a problematização de questões relativas à necessidade de regular alguns elementos da relação entre operadoras e prestadores hospitalares, fundamentais para a garantia do acesso e da qualificação da atenção recebida por clientes de operadoras de planos privados de saúde; e também relativas à importância que os prestadores hospitalares privados possuem para o SUS. Busca-se, assim, a partir dos estudos sobre o tema, refletir tanto sobre o papel regulador a ser desempenhado pela ANS nas relações contratuais entre operadoras e prestadores, quanto sobre o papel que ao SUS caberia exercer.This paper discusses the regulatory role that would fit the National Supplementary Health Agency (ANS, from the results of researches and studies on the practices of micro-regulation performed by private managed care companies on hospital providers they contract. It is based on several studies, especially on the research by Ugá el al (2007, whose results allowed the questioning of issues related to the necessary regulation of some elements of the relationship between health managed care companies and hospital providers, key to ensuring access and qualification of health care received by customers of those companies, as well as the importance that hospital providers have for the public health system, SUS. The paper aims, therefore, from the studies on the subject, to reflect on the regulatory role to be played by ANS in the contractual relations between managed care companies and providers and on the role that would fit

  7. LATE ONSET ATRIOVENTRICULAR NODAL TACHYCARDIA

    NARCIS (Netherlands)

    PENTINGA, ML; MEEDER, JG; CRIJNS, HJGM; DEMUINCK, ED; WIESFELD, ACP; LIE, KI

    AV nodal tachycardia may present at any age, but onset in late adulthood is considered uncommon. To evaluate whether onset of AV nodal tachycardias at older age is related to organic heart disease (possibly setting the stage for re-entry due to degenerative structural changes) 32 consecutive

  8. LATE ONSET ATRIOVENTRICULAR NODAL TACHYCARDIA

    NARCIS (Netherlands)

    PENTINGA, ML; MEEDER, JG; CRIJNS, HJGM; DEMUINCK, ED; WIESFELD, ACP; LIE, KI

    1993-01-01

    AV nodal tachycardia may present at any age, but onset in late adulthood is considered uncommon. To evaluate whether onset of AV nodal tachycardias at older age is related to organic heart disease (possibly setting the stage for re-entry due to degenerative structural changes) 32 consecutive patient

  9. Setting oral health goals that include oral health-related quality of life measures: a study carried out among adolescents in Thailand Incorporação da qualidade de vida relacionada à saúde bucal em metas de saúde bucal: estudo conduzido em adolescentes tailandeses

    Directory of Open Access Journals (Sweden)

    Sudaduang Krisdapong

    2012-10-01

    Full Text Available The aim of this study was to assess the association between oral diseases and condition-specific oral health-related quality of life (CS-OHRQoL as a basis for proposing OHRQoL-based goals for the population of 15-year-olds in Thailand. Oral examinations and OHRQoL interviews were conducted with 871 15-year-olds as part of the Sixth Thailand National Oral Health Survey. The severity of oral impacts was categorized using "intensity". Associations between oral diseases and CS-OHRQoL were analyzed using chi-square and logistic regression. Thirty-nine percent of 15-year-olds experienced moderate/higher levels oral impacts on quality of life. Compared to those individuals with no tooth decay, adolescents with one or four or more decaying teeth were three and seven times more likely to experience moderate/higher impacts, respectively. Adolescents with extensive gingivitis in 3 or more mouth sextants were twice as likely to experience moderate/higher CS-impacts. Based on these findings, it is proposed that goals should focus on untreated decaying teeth and extensive gingivitis. Oral health goals for 15-year-olds should include specific OHRQoL measures.O objetivo deste estudo foi avaliar a associação entre doença bucal e a condição específica de qualidade de vida associada à saúde bucal (CS-OHRQoL, como base para propor OHRQoL metas para adolescentes tailandeses. Exame clínico bucal e entrevista foram realizados em 871 adolescentes na faixa etária de 15 anos, como parte da 6ª Pesquisa Nacional Tailandesa de Saúde Bucal. A severidade do impacto bucal foi categorizada usando-se a "intensidade". A associação entre doença bucal e CS-OHRQoL foi investigada usando-se o teste qui-quadrado e regressão lógica. Trinta e nove por cento da amostra reportaram impactos bucais de grau moderado/elevado. A probabilidade de reportar um impacto bucal de grau moderado/elevado dos adolescentes com um dente cariado e aqueles com 4 ou mais foi 3 e 7 vezes

  10. Riscos ocupacionais na legislação trabalhista brasileira: destaque para aqueles relativos à saúde e à voz do professor Occupational risks in the Brazilian labor legislation: highlight on those related to teacher's health and voice

    Directory of Open Access Journals (Sweden)

    Emilse Aparecida Merlin Servilha

    2010-12-01

    Full Text Available OBJETIVO: Analisar a legislação a respeito de riscos ocupacionais, com destaque para aqueles relacionados à saúde e à voz do professor. MÉTODOS: Trata-se de pesquisa bibliográfica, de caráter qualitativo, que considerou as políticas públicas sobre Saúde e Segurança no Trabalho. As Normas Regulamentadoras foram lidas e seus conteúdos analisados e organizados por categorias, com recorte para aqueles referentes ao ambiente escolar. RESULTADOS: As 33 normas focalizam os fatores de risco, níveis de tolerância e controle para saúde e segurança no trabalho. Os agentes ambientais nocivos são múltiplos e suas especificidades, como concentração e frequência, determinam o nível de tolerância à exposição. Na escola, os riscos ambientais como ruído, poeira, temperatura e iluminação inadequadas, dentre outros, estão presentes, porém em grau leve. O tratamento acústico, de iluminação e de ventilação é indicado para controle desses riscos. Os documentos mostram situações de agravos à saúde dos trabalhadores em graus de risco muito maiores do que aqueles da docência. Não há explicitação de fatores inerentes à organização do trabalho e os cuidados com a voz limitam-se à profissão de teleoperador, o que pode servir de referência para o professor. CONCLUSÃO: A legislação trabalhista é ampla ao abarcar a diversidade de condições de trabalho e garantir a saúde dos trabalhadores. A docência apresenta riscos ocupacionais à saúde mais leves do que outras profissões; contudo, os fatores organizacionais do trabalho, assim como os distúrbios de voz, muito frequentes na docência, carecem de maior atenção da legislação no Brasil.PURPOSE: To analyze the legislation regarding occupational risks, highlighting those related to teacher's health and voice. METHODS: A bibliographic search of qualitative nature regarding the public policies about Health and Security at Work was carried out. The Regulatory

  11. Aspectos cinemáticos e neuromusculares relacionados com o desempenho da saída do bloco na natação Kinematical and neuromuscular aspects related to performance during the swimming start

    Directory of Open Access Journals (Sweden)

    Daniele Detanico

    2011-12-01

    Full Text Available O objetivo deste estudo foi relacionar o desempenho (distância e tempo de voo na saída de bloco com variáveis cinemáticas e neuromusculares. Participaram 10 nadadores do sexo masculino (26,4 ± 6,6 anos, 76,4 ± 6,6 kg, 1,81 ± 0,07 m de estatura. Utilizou-se uma câmera filmadora (30 Hz para a aquisição das variáveis cinemáticas, sendo analisadas: distância de voo, tempo de voo, altura máxima do quadril, ângulos de saída de bloco e entrada na água. Para a obtenção da potência muscular foi utilizado o "Squat Jump" realizado sobre uma plataforma de força. Foram obtidas as seguintes variáveis: altura do salto, potência e pico de velocidade. Utilizou-se estatística descritiva e correlação de Pearson para relacionar as variáveis neuromusculares e cinemáticas com o desempenho na saída de bloco, utilizando nível de significância de 5%. Encontrou-se correlação significativa do ângulo de saída com a distância (r = -0,59 e com o tempo de voo (r = 0,88, além da altura máxima com o tempo de voo (r = 0,59. Não foi observada correlação significativa da distância e do tempo de voo com as variáveis neuromusculares (p > 0,05. Com base nos resultados pode-se concluir que o desempenho na saída de bloco da natação foi relacionado com o ângulo de saída de bloco e com a altura máxima do quadril na fase aérea. A potência muscular não interferiu no desempenho nos nadadores investigados.The aim of this study was to investigate the association between the performance of the start off the swimming block with kinematical and neuromuscular parameters (flight distance and flight time. Ten male swimmers (26.4 ± 6.6 years, 76.4 ± 6.6 kg, 1.81 ± 0.07 m participated in the study. A video camera (30 Hz was used to obtain the kinematic variables: flight distance, flight time, maximum height, start angle and entry angle. Muscle power was assessed via the performance of a Squat Jump on a force plate. Jump height, power and peak of

  12. Viruses as the causative agent related to 'dampness' and the missing link between allergen exposure and onset of allergic disease

    DEFF Research Database (Denmark)

    Hersoug, Lars-Georg

    2005-01-01

    . The infectious effectiveness of respiratory viruses depends strongly on the environment where the viruses are spread. For respiratory viruses, survival and infectivity are dependent on temperature and relative humidity. A direct link between virus-induced inflammation and the asthmatogenic process has been...... proposed. Therefore, a more effective spreading of viral infections in damp indoor climates is likely to represent the main cause for the increased prevalence of asthma in these environments. Moreover, the incidence of viral infections is higher in patients with asthma compared with that in control...

  13. Sasang Medical Perspectives on Viral Immunity: A Discussion of Intrinsic, Constitutionally Related Factors in Disease Onset and Resistance

    Directory of Open Access Journals (Sweden)

    Gary Wagman

    2017-02-01

    Full Text Available There remain more questions than answers regarding the manifestation of certain diseases, such as Ebola, in some otherwise healthy individuals but not in others. Sasang medicine offers a possible clue to solving this mystery by introducing a constitutionally based, intrinsic approach to determining disease susceptibility. The Sasang constitution is identified by a detailed examination of inherent physiological and psychological traits that are likely, but not yet, to be associated with specific genetic patterns. Hence, it is anticipated that after further examination, the Sasang model will contribute to the advancement of medical research and treatment by establishing genetically traceable psychological and physiological traits that contribute to, or offer protection against, various diseases. To progress along this journey, additional research involving Sasang-based organ-associated emotions and inherent emotional/physiological inclinations is warranted. This study presents an argument in favor of additionally examining constitutionally specific disease components related to viral epidemiology.

  14. Analysis on related risk factors of onset of asthma in children%儿童哮喘发病的相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    何少为; 薛幸

    2012-01-01

    目的:探讨儿童哮喘发病的相关危险因素,为预防儿童哮喘提供理论依据.方法:选择2008年12月~ 2011年12月120例哮喘患儿为病例组,同时选择无呼吸道疾病的儿童240例为对照组,采用单因素和多因素非条件Logistic回归分析法,分析儿童哮喘发病的危险因素.结果:过敏史、特应性、家族有哮喘史、家族有过敏史、近期有严重的呼吸道感染和父母一方吸烟是儿童哮喘发病的相关危险因素.结论:对于有哮喘危险因素的患儿,应预防呼吸道感染,减少过敏原的接触,防止被动吸烟.%Objective; To explore the related risk factors of onset of asthma in children, and provide a theoretical basis for preventing childhood asthma. Methods: One hundred and twenty children with asthma were selected as case group from December 2008 to December 2011 , and 240 children without respiratory diseases during the same period were selected as control group; non - conditional univariate and multivariate logistic regression analysis were adopted to analyze the risk factors of onset of asthma in children. Results: The related risk factors of onset of asthma in children included allergic history, idiocrasy, family histories of asthma and allergy, severe respiratory infection in the recent period, and smoking of one of the parent. Conclusion; For the children with risk factors of asthma, respiratory infection should be prevented, exposure to allergens should be reduced, and passive smoking should be avoided.

  15. Sasang Medical Perspectives on Viral Immunity: A Discussion of Intrinsic, Constitutionally Related Factors in Disease Onset and Resistance.

    Science.gov (United States)

    Wagman, Gary

    2017-01-01

    There remain more questions than answers regarding the manifestation of certain diseases, such as Ebola, in some otherwise healthy individuals but not in others. Sasang medicine offers a possible clue to solving this mystery by introducing a constitutionally based, intrinsic approach to determining disease susceptibility. The Sasang constitution is identified by a detailed examination of inherent physiological and psychological traits that are likely, but not yet, to be associated with specific genetic patterns. Hence, it is anticipated that after further examination, the Sasang model will contribute to the advancement of medical research and treatment by establishing genetically traceable psychological and physiological traits that contribute to, or offer protection against, various diseases. To progress along this journey, additional research involving Sasang-based organ-associated emotions and inherent emotional/physiological inclinations is warranted. This study presents an argument in favor of additionally examining constitutionally specific disease components related to viral epidemiology. Copyright © 2016 Medical Association of Pharmacopuncture Institute. Published by Elsevier B.V. All rights reserved.

  16. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.

    Science.gov (United States)

    Schulz, Tim J; Graja, Antonia; Huang, Tian Lian; Xue, Ruidan; An, Ding; Poehle-Kronawitter, Sophie; Lynes, Matthew D; Tolkachov, Alexander; O'Sullivan, Lindsay E; Hirshman, Michael F; Schupp, Michael; Goodyear, Laurie J; Mishina, Yuji; Tseng, Yu-Hua

    2016-08-01

    Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate the role of BMP signalling in adipose tissue health and systemic glucose homeostasis. We employed the Cre/loxP system to generate mouse models with conditional ablation of BMP receptor 1A in differentiating and mature adipocytes, as well as tissue-resident myeloid cells. Metabolic variables were assessed by glucose and insulin tolerance testing, insulin-stimulated glucose uptake and gene expression analysis. Conditional deletion of Bmpr1a using the aP2 (also known as Fabp4)-Cre strain resulted in a complex phenotype. Knockout mice were clearly resistant to age-related impairment of insulin sensitivity during normal and high-fat-diet feeding and showed significantly improved insulin-stimulated glucose uptake in brown adipose tissue and skeletal muscle. Moreover, knockouts displayed significant reduction of variables of adipose tissue inflammation. Deletion of Bmpr1a in myeloid cells had no impact on insulin sensitivity, while ablation of Bmpr1a in mature adipocytes partially recapitulated the initial phenotype from aP2-Cre driven deletion. Co-cultivation of macrophages with pre-adipocytes lacking Bmpr1a markedly reduced expression of proinflammatory genes. Our findings show that altered BMP signalling in adipose tissue affects the tissue's metabolic properties and systemic insulin resistance by altering the pattern of immune cell infiltration. The phenotype is due to ablation of Bmpr1a specifically in pre-adipocytes and maturing adipocytes rather than an immune cell-autonomous effect. Mechanistically, we provide evidence for a BMP-mediated direct crosstalk between pre-adipocytes and macrophages.

  17. Relationship between health-related quality of life, disease activity and disease damage in a prospective international multicenter cohort of childhood onset systemic lupus erythematosus patients.

    Science.gov (United States)

    Moorthy, L N; Baldino, M E; Kurra, V; Puwar, D; Llanos, A; Peterson, M G E; Hassett, A L; Lehman, T J A

    2017-03-01

    Previously, we described associations between health-related quality of life (HRQOL) and disease-related factors among childhood onset systemic lupus erythematosus (cSLE) patients. Here we determined the relationship between HRQOL, disease activity and damage in a large prospective international cohort of cSLE. We compared HRQOL, disease activity and disease damage across different continents and examined the relationship between children's and parents' assessments of HRQOL. Patients with cSLE and their parents completed HRQOL measures at enrollment and ≥4 follow-up visits. Physicians assessed disease activity and damage. The multinational cohort ( n = 467) had relatively low disease activity and damage. Patient and parent HRQOL scores were significantly correlated. Asian and European patients had the highest HRQOL, while South and North American patients had lower HRQOL scores. Renal, CNS, skin and musculoskeletal systems exhibited the highest levels of damage. North and South American and Asian patients were more likely to have disease damage and activity scores above median values, compared with Europeans. Asians were more likely to use cyclophosphamide/rituximab. Female gender, high disease activity and damage, non-White ethnicity, and use of cyclophosphamide and/rituximab were related to lower HRQOL. HRQOL domain scores continue to emphasize that SLE has widespread impact on all aspects of children's and parents' lives.

  18. Enamel defect of primary dentition in SGA children in relation to onset time of intrauterine growth disturbance

    Directory of Open Access Journals (Sweden)

    Willyanti Soewondo Sjarif

    2013-06-01

    Full Text Available Background: Prenatal disturbances disturb the development of organs resulting in small for gestational age (SGA babies and also causes enamel defects in primary teeth. There are disturbances occur in the beginning of pregnancy causing symmetrical SGA, and asymmetrical type of SGA, where the disturbances occur late in pregnancy. Purpose: This research was to determined differences in severity of enamel defect of primary dentition in small for gestational age children based on the time of intrauterine growth restriction. Methods: This was a clinical epidemiological cohort study. The Ponderal index was used to determine SGA type. The subjects were 129 SGA children aged 9-42 months, 82 with asymmetrical SGA and 47 with symmetrical SGA. Two hundred normal birth weight children were the control group. Intra-oral examinations to determine enamel defect used the FDI modification of the Developmental Defect of Enamel score at 3 months intervals. Statistical t-tests were used to test the difference in severity of enamel defect, and chisquare to find out the difference of Relative Risk Ratio (RRR. Results: The results showed that the enamel defect scores of symmetrical SGA were significantly higher than those with asymmetrical SGA. RRR for severe defect was also significantly higher in symmetrical type for anterior and canines. Conclusion: The study suggested that the severity of enamel defect for infants with symmetrical SGA was higher than those with asymmetrical SGA, indicating that the severity of the defect occurs in the beginning of pregnancy is more severe than in the late pregnancy.Latar belakang: Adanya gangguan prenatal mengganggu perkembangan organ, mengakibatkan terjadinya bayi lahir dengan kecil masa kehamilan (KMK dan defek email pada gigi sulung. Terdapat 2 tipe KMK yaitu tipe simetri; gangguan terjadi pada awal kehamilan; dimana lingkar kepala, berat dan panjang lahir lebih rendah dari normal. Tipe asimetri dimana gangguan terjadi saat

  19. Replication of interleukin 23 receptor and autophagy- related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

    Institute of Scientific and Technical Information of China (English)

    Anna Latiano; Gian Luigi de Angelis; Giuseppe Corritore; Fabrizio Bossa; Vito Annese; Orazio Palmieri; Maria Rosa Valvano; Renata D'Incà; Salvatore Cucchiara; Gabriele Riegler; Anna Maria Staiano; Sandro Ardizzone; Salvatore Accomando

    2008-01-01

    AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes.METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age < 19 years),843 with ulcerative colitis (UC, 179 diagnosed <19 years), 749 healthy controls, and 546 healthy parents (273 trios) were included in the study. The rs2241880 [autophagy-related 16-like i (ATG16L1)],rs11209026 and rs7517847 [interleukin 23 receptor (IL23R)], rs2066844, rs2066845, rs2066847 (CARD15),rs1050152 (OCTN1), and rs2631367 (OCTN2) gene variants were genotyped.RESULTS: The frequency of G allele of ATG16L1 SNP (Ala197Thr) was increased in patients with CD compared with controls (59% vs 54% respectively)(OR = 1.25, CI = 1.08-1.45, P = 0.003), but not in UC (55%). The frequency of A and G (minor) alleles of Arg381GIn, rs11209026 and rs7517847 variants of IL23R were reduced significantly in CD (4%, OR =0.62, CI = 0.45-0.87, P = 0.005; 28%, OR = 0.64, CI= 0.55-0.75, P < 0.01), compared with controls (6%and 38%, respectively). The A allele (but not G) wasalso reduced significantly in UC (4%, OR = 0.69, CI =0.5-0.94, P = 0.019). No association was demonstrated with sub-phenotypes and interaction with CARD15,and OCTN1/2 genes, although both gene variants were associated with pediatric-onset disease.CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population.

  20. Non-polar lipids accumulate during storage of transfusion products and do not contribute to the onset of transfusion-related acute lung injury.

    Science.gov (United States)

    Peters, A L; Vervaart, M A T; van Bruggen, R; de Korte, D; Nieuwland, R; Kulik, W; Vlaar, A P J

    2017-01-01

    The accumulation of non-polar lipids arachidonic acid, 5-hydroxyeicosatetraenoic acid (HETE), 12-HETE and 15-HETE during storage of transfusion products may play a role in the onset of transfusion-related acute lung injury (TRALI), a syndrome of respiratory distress after transfusion. We investigated non-polar lipid accumulation in red blood cells (RBCs) stored for 42 days, plasma stored for 7 days at either 4 or 20°C and platelet (PLT) transfusion products stored for 7 days. Furthermore, we investigated whether transfusion of RBCs with increased levels of non-polar lipids induces TRALI in a 'two-hit' human volunteer model. All products were produced following Dutch Blood Bank protocols and are according to European standards. Non-polar lipids were measured with high-performance liquid chromotography followed by mass spectrometry. All non-polar lipids increased in RBCs after 21 days of storage compared to baseline. The non-polar lipid concentration in plasma increased significantly, and the increase was even more pronounced in products stored at 20°C. In platelets, baseline levels of 5-HETE and 15-HETE were higher than in RBCs or plasma. However, the non-polar lipids did not change significantly during storage of PLT products. Infusion of RBCs with increased levels of non-polar lipids did not induce TRALI in LPS-primed human volunteers. We conclude that non-polar lipids accumulate in RBC and plasma transfusion products and that accumulation is temperature dependent. Accumulation of non-polar lipids does not appear to explain the onset of TRALI (Dutch Trial Register - NTR4455). © 2016 International Society of Blood Transfusion.

  1. Late-onset running biphasically improves redox balance, energy- and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus.

    Directory of Open Access Journals (Sweden)

    Stefano Falone

    Full Text Available Despite the active research in this field, molecular mechanisms underlying exercise-induced beneficial effects on brain physiology and functions are still matter of debate, especially with regard to biological processes activated by regular exercise affecting the onset and progression of hippocampal aging in individuals unfamiliar with habitual physical activity. Since such responses seem to be mediated by changes in antioxidative, antiglycative and metabolic status, a possible exercise-induced coordinated response involving redox, methylglyoxal- and sirtuin-related molecular networks may be hypothesized. In this study, hippocampi of CD1 mice undergoing the transition from mature to middle age were analyzed for redox-related profile, oxidative and methylglyoxal-dependent damage patterns, energy metabolism, sirtuin1 and glyoxalase1 expression after a 2- or 4-mo treadmill running program. Our findings suggested that the 4-mo regular running lowered the chance of dicarbonyl and oxidative stress, activated mitochondrial catabolism and preserved sirtuin1-related neuroprotection. Surprisingly, the same cellular pathways were negatively affected by the first 2 months of exercise, thus showing an interesting biphasic response. In conclusion, the duration of exercise caused a profound shift in the response to regular running within the rodent hippocampus in a time-dependent fashion. This research revealed important details of the interaction between exercise and mammal hippocampus during the transition from mature to middle age, and this might help to develop non-pharmacological approaches aimed at retarding brain senescence, even in individuals unfamiliar with habitual exercise.

  2. Early-onset age-related changes in dendritic cell subsets can impair antigen-specific T helper 1 (Th1) CD4 T cell priming.

    Science.gov (United States)

    Farazi, Michelle; Cohn, Zachary; Nguyen, Justine; Weinberg, Andrew D; Ruby, Carl E

    2014-08-01

    Decline in CD4 T cell immune responses is associated with aging. Although a number of immunological defects have been identified in elderly mice (>18 months old), a key early-onset immune defect at middle age could be a driver or contributor to defective CD4 T cell responses. Our studies demonstrate that age-related alterations in DC subsets within the priming environment of middle-aged mice (12 months old) correlate with and can directly contribute to decreases in antigen-specific CD4 T cell Th1 differentiation, which measured by T-bet and IFN-γ expression, was decreased significantly in T cells following VSV infection or s.c. immunization with a protein antigen in the context of immune stimulation via OX40. The deficient Th1 phenotype, observed following protein antigen challenge, was found to be the result of an age-related decrease in an inflammatory DC subset (CD11b+ Gr-1/Ly6C+) in the dLN that corresponded with T cell dysfunction. In the virus model, we observed significant changes in two DC subsets: mDCs and pDCs. Thus, different, early age-related changes in the DC profile in the priming environment can significantly contribute to impaired Th1 differentiation, depending on the type of immunological challenge. © 2014 Society for Leukocyte Biology.

  3. SEASONAL AND INTER-ANNUAL VARIABILITY OF THE SOUTH CHINA SEA WARM POOL AND ITS RELATION TO THE SOUTH CHINA SEA MONSOON ONSET

    Institute of Scientific and Technical Information of China (English)

    赵永平; 陈永利

    2001-01-01

    The South China Sea warm pool interacts vigorously with the summer monsoon which is active in the region. However, there has not been a definition concerning the former warm pool which is as specific as that for the latter. The seasonal and inter-annual variability of the South China Sea warm pool and its relations to the South China Sea monsoon onset were analyzed using Levitus and NCEP/NCAR OISST data. The results show that, the seasonal variability of the South China Sea warm pool is obvious, which is weak in winter, develops rapidly in spring, becomes strong and extensive in summer and early autumn, and quickly decays from mid-autumn. The South China Sea warm pool is 55 m in thickness in the strongest period and its axis is oriented from southwest to northeast with the main section locating along the western offshore steep slope of northern Kalimantan-Palawan Island. For the warm pools in the South China Sea, west Pacific and Indian Ocean, the oscillation, which is within the same large scale air-sea coupling system, is periodic around 5 years. There are additional oscillations of about 2.5 years and simultaneous inter-annual variations for the latter two warm pools. The intensity of the South China Sea warm pool varies by a lag of about 5 months as compared to the west Pacific one. The result also indicates that the inter-annual variation of the intensity index is closely related with the onset time of the South China Sea monsoon. When the former is persistently warmer (colder) in preceding winter and spring, the monsoon in the South China Sea usually sets in on a later (earlier) date in early summer. The relation is associated with the activity of the high pressure over the sea in early summer. An oceanic background is given for the prediction of the South China Sea summer monsoon, though the mechanism through which the warm pool and eventually the monsoon are affected remains unclear.

  4. Rhizobacterial volatiles and photosynthesis-related signals coordinate MYB72 expression in Arabidopsis roots during onset of induced systemic resistance and iron-deficiency responses.

    Science.gov (United States)

    Zamioudis, Christos; Korteland, Jolanda; Van Pelt, Johan A; van Hamersveld, Muriël; Dombrowski, Nina; Bai, Yang; Hanson, Johannes; Van Verk, Marcel C; Ling, Hong-Qing; Schulze-Lefert, Paul; Pieterse, Corné M J

    2015-10-01

    In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling. Here, we show that volatile organic compounds (VOCs) from ISR-inducing Pseudomonas bacteria are important elicitors of MYB72. In response to VOC treatment, MYB72 is co-expressed with the iron uptake-related genes FERRIC REDUCTION OXIDASE 2 (FRO2) and IRON-REGULATED TRANSPORTER 1 (IRT1) in a manner that is dependent on FER-LIKE IRON DEFICIENCY TRANSCRIPTION FACTOR (FIT), indicating that MYB72 is an intrinsic part of the plant's iron-acquisition response that is typically activated upon iron starvation. However, VOC-induced MYB72 expression is activated independently of iron availability in the root vicinity. Moreover, rhizobacterial VOC-mediated induction of MYB72 requires photosynthesis-related signals, while iron deficiency in the rhizosphere activates MYB72 in the absence of shoot-derived signals. Together, these results show that the ISR- and iron acquisition-related transcription factor MYB72 in Arabidopsis roots is activated by rhizobacterial volatiles and photosynthesis-related signals, and enhances the iron-acquisition capacity of roots independently of the iron availability in the rhizosphere. This work highlights the role of MYB72 in plant processes by which root microbiota simultaneously stimulate systemic immunity and activate the iron-uptake machinery in their host plants.

  5. Articular saúde mental e relações de gênero: dar voz aos sujeitos silenciados Articulate mental health and social gender relations: giving voice to silenced subjects

    Directory of Open Access Journals (Sweden)

    Anna Maria Corbi Caldas dos Santos

    2009-08-01

    Full Text Available Analisa-se a experiência do sofrimento psíquico a partir de relatos de homens e mulheres usuários de serviço público de saúde do município de Araraquara (SP. Considera-se a construção social do sofrimento psíquico e, portanto, a conformação dos valores e normas de determinada sociedade e época histórica. Utilizaram-se entrevistas semi-estruturadas com usuários do Centro de Atenção Psicossocial (CAPS, homens e mulheres, analisadas sob a ótica das relações sociais de gênero e do contexto das mudanças no sistema psiquiátrico brasileiro a partir da luta antimanicomial. Conclui-se que o desafio a ser enfrentado pela sociedade brasileira contemporânea na construção de políticas públicas para saúde mental deve levar em conta questões postas pela perspectiva das relações sociais de gênero. Portanto, significa, ao incorporar o tema gênero no âmbito da saúde mental, questionar uma concepção reducionista e biologizante da saúde mental das mulheres. Verificou-se que o adoecimento psíquico feminino mantém estreita correlação com a violência contra as mulheres e a repressão sexual ainda vigente na sociedade. No que tange à vivência do adoecimento psíquico masculino, requer enfrentar a questão do estigma. Estes, ao adoecerem, são excluídos do espaço público e enfrentam maiores dificuldades de reinserção social e de reconstrução da identidade anterior.The experience of the psychological suffering based on testimonies of male and female users of a public health service in the municipality of Araraquara (SP. It is considered the social construction of the psychological suffering and, therefore, the arrangement of values and norms of a certain society and historical period. Semi-structured interviews were applied in male and female users of the Center of Psychosocial Attention (CAPS. These interviews were analyzed through the perspective of social gender relations and under the context of changes at the

  6. Lewis Porter, John Coltrane. Sa vie, sa musique

    OpenAIRE

    Parent, Emmanuel

    2008-01-01

    Les éditions Outre Mesure viennent de mettre à la disposition du lectorat français, avec la qualité de mise en page et en musique qu’on leur connaît, un nouveau livre de référence en musicologie du jazz. Salué à sa sortie par la critique en langue anglaise en 1998, John Coltrane. Sa vie, sa musique constitue en effet un ouvrage fort complet pour qui veut s’immerger dans le langage du heavyweight champion. L’auteur, enseignant à Rutgers (l’université du New Jersey abritant depuis les années 19...

  7. Etude de la relation entre le scolyte des rameaux du cafeier, Xyleborus compactus Eichh. (X. morstatti Hag.), et sa plante-hote

    NARCIS (Netherlands)

    Brader, L.

    1964-01-01

    The mutual relation between the coffee-twig beetle, an ambrosia beetle, and the coffee plant was analysed as an example of the relation between insect and host plant. By boring passages in the twigs of the coffee plant, the beetle killed the twigs. Control was hindered by the feeding of the beetle

  8. Prospective assessment of health-related quality of life in men with late-onset hypogonadism who received testosterone replacement therapy.

    Science.gov (United States)

    Sumii, K; Miyake, H; Enatsu, N; Matsushita, K; Fujisawa, M

    2016-03-01

    The objective of this study was to characterise the status of health-related quality of life (HRQOL) in Japanese men with late-onset hypogonadism (LOH) treated with testosterone replacement therapy (TRT). HRQOL in 69 consecutive Japanese men with LOH undergoing TRT for at least 6 months was prospectively evaluated before and 6 months after the initiation of TRT using the Medical Outcomes Study 8-Item Short-Form Health Survey (SF-8). All eight-scale scores except for bodily pain (BP) in the 69 patients at 6 months after the introduction of TRT significantly improved compared with those before TRT; however, all scale scores except for BP in the 69 patients were significantly inferior to those in age-matched Japanese controls irrespective of the timing of SF-8. Multivariate analyses of several parameters revealed that both age and Aging Male Symptom (AMS) score had an independent impact on mental health (MH), despite the lack of an independent association between any score and the remaining factors examined. TRT appeared to significantly improve the status of HRQOL in men with LOH; however, even after the introduction of TRT, HRQOL associated with MH remained significantly impaired in elderly men and/or those with a high AMS score.

  9. Late onset of dietary restriction reverses age-related decline of malate-aspartate shuttle enzymes in the liver and kidney of mice.

    Science.gov (United States)

    Goyary, Danswrang; Sharma, Ramesh

    2008-02-01

    Dietary restriction (DR) influences several physiological processes, retards the incidences and severity of various age-related diseases and extends lifespan of various animal species. The effect of DR on the activities of malate-aspartate shuttle enzymes, viz. cytosolic and mitochondrial aspartate aminotransferase (c- and m-AsAT) and malate dehydrogenase (c- and m-MDH) was investigated in the liver and kidney of adult (5-months) and old (21-months) male mice. The results show that the activity (U/mg protein) of both c- and m-MDH and AsAT is decreased significantly in the liver and kidney of old mice compared to adult ones. However, DR in old mice reverses significantly the enzyme activities to a level closer to adult animals. Polyacrylamide gel electrophoresis (PAGE) and specific staining of c-AsAT, one of the selected isoenzymes of the shuttle, showed a similar pattern of activity expression as observed by activity measurements in both the tissues studied. Slot blot analysis of c-AsAT confirmed the lower protein content of this isoenzyme in old mice compared to adult ones and a higher level in old-dietary restricted mice. Thus, our results suggest that the late onset of DR in older mice reverses decline in malate-aspartate shuttle enzymes and that it may allow a better metabolic regulation in older animals.

  10. Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Nian, Y; Ding, M; Hu, S; He, H; Cheng, S; Yi, L; Li, Y; Wang, Y

    2017-05-01

    Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score. © 2016 Blackwell Verlag GmbH.

  11. Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions

    Directory of Open Access Journals (Sweden)

    Mannelli P

    2011-05-01

    Full Text Available Li-Tzy Wu1, George E Woody2, Chongming Yang3, Paolo Mannelli1, Dan G Blazer11Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA; 2Department of Psychiatry, University of Pennsylvania School of Medicine, University of Pennsylvania and Treatment Research Institute, Philadelphia, PA, USA; 3Social Science Research Institute, Duke University, Durham, NC, USAObjectives: To examine patterns of onset and abuse/dependence episodes of prescription opioid (PO and heroin use disorders in a national sample of adults, and to explore differences by gender and substance abuse treatment status.Methods: Analyses of data from the 2001–2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093.Results: Of all respondents, 5% (n = 1815 reported a history of nonmedical PO use (NMPOU and 0.3% (n = 150 a history of heroin use. Abuse was more prevalent than dependence among NMPOUs (PO abuse, 29%; dependence, 7% and heroin users (heroin abuse, 63%; dependence, 28%. Heroin users reported a short mean interval from first use to onset of abuse (1.5 years or dependence (2.0 years, and a lengthy mean duration for the longest episode of abuse (66 months or dependence (59 months; the corresponding mean estimates for PO abuse and dependence among NMPOUs were 2.6 and 2.9 years, respectively, and 31 and 49 months, respectively. The mean number of years from first use to remission from the most recent episode was 6.9 years for PO abuse and 8.1 years for dependence; the mean number of years from first heroin use to remission from the most recent episode was 8.5 years for heroin abuse and 9.7 years for dependence. Most individuals with PO or heroin use disorders were remitted from the most recent episode. Treated individuals, whether their problem was heroin or POs, tended to have a longer mean duration of an episode than untreated individuals.Conclusion: Periodic remissions

  12. Performance Evaluation Considering Iterations per Phase and SA Temperature in WMN-SA System

    Directory of Open Access Journals (Sweden)

    Shinji Sakamoto

    2014-01-01

    Full Text Available One of the key advantages of Wireless Mesh Networks (WMNs is their importance for providing cost-efficient broadband connectivity. There are issues for achieving the network connectivity and user coverage, which are related with the node placement problem. In this work, we consider Simulated Annealing Algorithm (SA temperature and Iteration per phase for the router node placement problem in WMNs. We want to find the optimal distribution of router nodes in order to provide the best network connectivity and provide the best coverage in a set of Normal distributed clients. From simulation results, we found how to optimize both the size of Giant Component and number of covered mesh clients. When the number of iterations per phase is big, the performance is better in WMN-SA System. From for SA temperature, when SA temperature is 0 and 1, the performance is almost same. When SA temperature is 2 and 3 or more, the performance decrease because there are many kick ups.

  13. Sequence determinants for DNA packaging specificity in the S. aureus pathogenicity island SaPI1.

    Science.gov (United States)

    Bento, Joana C; Lane, Kristin D; Read, Erik K; Cerca, Nuno; Christie, Gail E

    2014-01-01

    The SaPIs and their relatives are a family of genomic islands that exploit helper phages for high frequency horizontal transfer. One of the mechanisms used by SaPIs to accomplish this molecular piracy is the redirection of the helper phage DNA packaging machinery. SaPIs encode a small terminase subunit that can be substituted for that of the phage. In this study we have determined the initial packaging cleavage sites for helper phage 80α, which uses the phage-encoded small terminase subunit, and for SaPI1, which uses the SaPI-encoded small terminase subunit. We have identified a 19nt SaPI1 sequence that is necessary and sufficient to allow high frequency 80α transduction of a plasmid by a terminase carrying the SaPI1-encoded small subunit. We also show that the hybrid enzyme with the SaPI1 small terminase subunit is capable of generalized transduction.

  14. World Trade Center Health Program; Addition of New-Onset Chronic Obstructive Pulmonary Disease and WTC-Related Acute Traumatic Injury to the List of WTC-Related Health Conditions. Final rule.

    Science.gov (United States)

    2016-07-05

    The World Trade Center (WTC) Health Program conducted a review of published, peer-reviewed epidemiologic studies regarding potential evidence of chronic obstructive pulmonary disease (COPD) and acute traumatic injury among individuals who were responders to or survivors of the September 11, 2001, terrorist attacks. The Administrator of the WTC Health Program (Administrator) found that these studies provide substantial evidence to support a causal association between each of these health conditions and 9/11 exposures. As a result, the Administrator is publishing a final rule to add both new-onset COPD and WTC-related acute traumatic injury to the List of WTC-Related Health Conditions eligible for treatment coverage in the WTC Health Program.

  15. Barriers and facilitators related to the uptake of four strategies to prevent neonatal early-onset group B haemolytic streptococcus disease: a qualitative study.

    Science.gov (United States)

    Kolkman, Diny G E; Fleuren, Margot A H; Wouters, Maurice G A J; de Groot, Christianne J M; Rijnders, Marlies E B

    2017-05-09

    Actions to prevent early onset disease in neonates are based on different strategies including administering antibiotic prophylaxis during labour in case of 1) maternal GBS colonisation (screening strategy), 2) identified risk factors (risk-based strategy) or 3) a combination of these two conditions (maternal GBS colonisation and identified risk factors: combination strategy and the Dutch guideline). Low adherence to guidelines preventing EOGBS has been reported. Each strategy has drawbacks and clinical outcomes are affected by care providers' and women's adherence. The actual impact of any preventive strategy is the product of efficacy of the strategy and the level of implementation. In order to reduce neonatal death due to EOGBS by developing the optimal guideline, we analysed barriers and facilitators of current used strategies. Focus group and personal interviews with care providers and women were performed. Impeding and enhancing factors in adherence to the preventive strategies were discussed and scored using the Measurement Instrument for Determinants of Innovations (MIDI) and analysed by two independent researchers. Overall, care providers identified 3.6 times more factors that would impede (n = 116) rather than facilitate (n = 32) adherence to the preventive strategies. 28% facilitative factors were reported in relation to the combination strategy and 86% impeding factors in relation to the Dutch guideline. The most preferred strategy was the combination strategy by 74% of the care providers and by 86% of the women. We obtained a detailed understanding of factors that influence adherence to preventive strategies. This insight can be used to develop implementation activities to improve the uptake of new strategies. The trial is registered in the Dutch Trial Register NTR3965 .

  16. Work-related mental disorders and their inclusion in health policies in the Brazilian Unified Health System (Sistema Único de Saúde).

    Science.gov (United States)

    Cocchiola-Silva, Rafaela A

    2016-03-01

    This study discusses the inclusion of mental disorders as work-related diseases in occupational health policies in Brazil. Mental disorders first appeared as a group of occupational diseases in 1999. Establishing mental disorders as occupational diseases was a result of the confluence of several factors: a broader notion of health, a positive shift in public perception regarding preconceived judgements relating to mental disorders and the improvement in the process that defines social security benefit entitlements due to the implementation of a new methodology in 2007.

  17. Circadian Variation Of Stroke Onset

    Directory of Open Access Journals (Sweden)

    Kamath vasantha

    2003-01-01

    Full Text Available Diurnal variations in various physiological and biochemical functions and certain pathological events like myocardial infarction and stroke have been documented. We studied prospectively one hundred and seven patients of acute onset stroke confirmed by computed tomography for the exact time of onset, risk factors and type of stroke. Patients who were unclear of time of onset and with a diagnosis of cerebral venous thrombosis or sub-arachnoid hemorrhage were excluded. Infarction was detected in 71 patients and hemorrhage in 33 patients. Men out numbered women (1:6:1. Hypertension was more frequent in hemorrhage in the morning time (5 AM-12 noon and more infarction between 12-6 pm. However there was no relation between the time of onset of stroke and various risk-factors of stroke.

  18. Relative size of the eye and orbit: an evolutionary and craniofacial constraint model for examining the etiology and disparate incidence of juvenile-onset myopia in humans.

    Science.gov (United States)

    Masters, Michael P

    2012-05-01

    The principal aim of this research is to provide a new model for investigating myopia in humans, and contribute to an understanding of the degree to which modern variation and evolutionary change in orbital and overall craniofacial morphology may help explain the common eye form association with this condition. Recent research into long and short-term evolution of the human orbit reveals a number of changes in this feature, and particularly since the Upper Paleolithic. These include a reduction in orbital depth, a decrease in anterior projection of the upper and lower orbital margins, and most notably, a reduction in orbital volume since the Holocene in East Asia. Reduced orbital volume in this geographic region could exacerbate an existing trend in recent hominin evolution toward larger eyes in smaller orbits, and may help explain the unusually high frequency of myopia in East Asian populations. The objective of the current study is to test a null hypothesis of no relationship between a ratio of orbit to eye volume and spherical equivalent refractive error (SER) in a sample of Chinese adults, and examine how relative size of the eye within the orbit relates to SER between the sexes and across the sample population. Analysis of the orbit, eye, and SER reveals a strong relationship between relative size of the eye within the orbit and the severity of myopic refractive error. An orbit/eye ratio of 3 for females and 3.5 for males (or an eye that occupies approximately 34% and 29% of the orbit, respectively), designates a clear threshold at which myopia develops, and becomes progressively worse as the eye continues to occupy a greater proportion of the orbital cavity. These results indicate that relative size of the eye within the orbit is an important factor in the development of myopia, and suggests that individuals with large eyes in small orbits lack space for adequate development of ocular tissues, leading to compression and distortion of the lithesome globe

  19. 7,8-Dihydroxyflavone, a Tropomyosin-Kinase Related Receptor B Agonist, Produces Fast-Onset Antidepressant-Like Effects in Rats Exposed to Chronic Mild Stress

    Science.gov (United States)

    Chang, Hsin-An; Wang, Ying-Hsiu; Tung, Che-Se; Yeh, Chin-Bin

    2016-01-01

    Objective Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), play important roles in treating depression. In this experiment, we examined whether 7,8-dihydroxyflavone, a novel potent TrkB agonist, could reverse the behavioral and biochemical abnormalities induced by the chronic mild stress (CMS) paradigm in rats. Methods SD rats were exposed to a battery of stressors for 56 days. 7,8-dihydroxyflavone (5 and 20 mg/kg) were administered intraperitoneally during the last 28 days of the CMS paradigm. Rats were tested in sucrose consumption test (SCT), forced-swimming test (FST) and elevated T-maze (ETM). Serum corticosterone levels and hippocampal BDNF levels of the rats were measured. Results Four-week CMS on the rats induced their depression-like behavior in SCT. The CMS-reduced sucrose consumption was reversed starting from 7 days after the 7,8-dihydroxyflavone (20 mg/kg) treatment and remained across the subsequent treatment regime. 7,8-dihydroxyflavone, when given at 5 mg/kg for 3 weeks, reduced the immobility time in the FST in the CMS-subjected rats. Additionally, the 4-week treatment with 7,8-dihydroxyflavone (20 mg/kg) attenuated the CMS-induced increase in anxiety-like behavior in the ETM. For the CMS-subjected rats, 7,8-dihydroxyflavone treatment dose-dependently reduced their serum corticosterone levels but increased their hippocampal BDNF levels only at 5 mg/kg. Conclusion 7,8-dihydroxyflavone was beneficial for both depression and anxiety-like behaviors, and may exert fast-onset antidepressant effects. This provides a new insight into the pharmacological management of depression.

  20. Meta Analisis sa Pagsusuri ng Maiikling Kwento sa mga Tesis at Disertasyon

    Directory of Open Access Journals (Sweden)

    Regina I. Cuizon

    2014-10-01

    Full Text Available Anumang mga pagbabago na makikita sa mundo ay bunga ng pananaliksik. Ang meta-analisis ay isa sa mga bunga ng pananaliksik na ginagamit sa kasalukuyan bilang teknik upang malaman iba pang mga nagsulputang informasyon. Ito’y pag-aaral sa mga pag-aaral. Isang kritikal at sistematikong pagsusuri sa istruktura ng mga pag-aaral. Maging gabay sa mga gradwadong paaralan sa pagpili ng paksang pagaaralan. Pangunahing layunin na matiyak ang mga pamamaraan sa pagsusuri ng maiikling kwento ng mga tesis at disertasyong nagawa mula sa mga piling SUCs. Desinyong kwalitatibo - kontent analisis sa pagsusuri ng: kaanyuan ayon sa suliranin, metodolohiya, paglalahad at interpretasyon ng mga datos, natuklasan, konklusyon, at rekomendasyon; kahinatnan ayon sa pagkatulad, pagkakaiba at kabuluhan; Emerging tema. Napag-alaman na ang karaniwang pinag-aralan ay 30% kahalagahang pangkatauhan, 20% larawangdiwa ng mga kababaihan at 10% gramatikang aspeto. Sa metodolohiyang ginamit, 80% desinyong kwalitatibo at 20% kwantitatibo-kwalitatibo. Sa paglikom ng datos 60% diretsahang pagsusuri, 30% talatanungan at 10% tseklis. Sa pag-analisa 90% kontent analisis at 10% gramatikal analisis. Batay sa natuklasan, ang pagsusuri ng maiikling kwento sa mga tesis at disertasyon mula sa iba’t ibang paaralan gamit ang meta analisis ay isang epektibo, mabisa, objektibong paraan at kagamitan na magagamit sa makatarungang paghatol; pamumuna sa kabuluhan at kagandahan; paghaham- bing sa mga kritikal na isyu; at pormulasyon ng panibagong pamantayan at batas.

  1. Narrativas: utilização na pesquisa qualitativa em saúde Narrativas: utilización en la investigación cualitativa en salud Narratives: use in qualitative health-related research

    Directory of Open Access Journals (Sweden)

    Rosana Teresa Onocko Campos

    2008-12-01

    Full Text Available A presente revisão bibliográfica realiza um percurso por várias correntes do pensamento que se ocuparam do estudo das narrativas. Foram analisados estudos clássicos de estrutura narrativa oriundos da literatura, da história, da teoria da comunicação e da psicanálise a fim de explorar se suas categorias e conceitos seriam metodologicamente aplicáveis na pesquisa qualitativa em saúde. Nas conclusões, destaca-se a potencialidade de se utilizar narrativas para o estudo de situações nas quais interessem as mediações entre experiência e linguagem, estrutura e eventos, sujeitos e coletivos, memória e ação política - questões que tradicionalmente interessam à área de "Políticas, Planejamento e Gestão" da saúde coletiva brasileira.La revisión bibliográfica realiza un recorrido por varias corrientes del pensamiento que se ocuparon de estudiar las narrativas. Se analizaron estudios clásicos de estructura narrativa oriundos de la literatura, de la historia, de la teoría de la comunicación y del psicoanálisis para explorar si sus categorías y conceptos serian metodológicamente aplicables en la investigación cualitativa de la salud. En las conclusiones, se destaca la potencialidad de utilizarse narrativas para el estudio de situaciones en las cuales interesen las mediaciones entre experiencia y lenguaje, estructura y eventos, sujetos y colectivo, memoria y acción política- cuestiones que tradicionalmente interesan en el área de "Políticas, Planificación y Gestión" de la salud colectiva brasilera.The present bibliographic review followed a path through several chains of thought concerned with studying narratives. Some classical studies on narrative structure with origins within literature, history, communications theory and psychoanalysis were analyzed with the aim of exploring whether their categories and concepts would be methodologically applicable to qualitative health-related research. In the conclusions, the

  2. Representações de trabalhadores portuários de Santos-SP sobre a relação trabalho-saúde Representations of dock workers from Santos-SP concerning the relation between work and health

    Directory of Open Access Journals (Sweden)

    Rosana Machin

    2009-12-01

    Full Text Available O trabalho analisa as representações de trabalhadores portuários avulsos do Porto de Santos-SP acerca das condições de trabalho, da relação trabalho-saúde e das estratégias adotadas para o cuidado em saúde a partir da perspectiva de gênero e das masculinidades. A pesquisa de natureza qualitativa desenvolveu-se na área de abrangência do Porto de Santos-SP. Foram entrevistados representantes de diferentes categorias de trabalhadores portuários, totalizando 13 entrevistas. O Porto é descrito pelos trabalhadores portuários como local perigoso, com grande ocorrência de acidentes. Eles atribuem esse risco à organização do trabalho e às condições muito heterogêneas sob as quais ele é realizado cotidianamente. As transformações no contexto imediato do trabalho portuário, produzidas nas últimas décadas, trazem implicações acerca dos padrões de adoecimento e sofrimento dessa população específica, ao mesmo tempo em que exigem paulatina (reprodução de valores e significados sobre ser homem e ser trabalhador portuário.This study analyses the representations of individual dock workers at the Port of Santos (state of São Paulo concerning working conditions, the relation between work and health, and also the adopted health care strategies from the perspective of gender and masculinities. Qualitative research was developed and a total of 13 interviews were conducted with representatives from different categories of dock workers. The Port is described by the workers as a dangerous place, where accidents occur very frequently. They attribute this risk to the organization of labor and to the very heterogeneous conditions in which it is conducted on a daily basis. The transformations that happened in the past decades in the immediate context of work on the docks have implications regarding the patterns of illness and suffering of this specific population; at the same time, they demand the gradual (reproduction of values and

  3. Relações entre a saúde mental da gestante e o apego materno-fetal Relations between pregnant women's mental health and maternal-fetal attachment

    Directory of Open Access Journals (Sweden)

    Patrícia Alvarenga

    2012-12-01

    Full Text Available O estudo investigou as relações entre variáveis sociodemográficas, saúde mental da gestante e o apego materno-fetal no terceiro trimestre de gestação. Participaram do estudo 261 gestantes selecionadas através de amostragem por acessibilidade em quatro maternidades públicas. As gestantes responderam individualmente uma ficha de dados sociodemográficos, a Escala de Apego Materno-Fetal e o SRQ-20. A análise de regressão revelou que o número de filhos (4% e a saúde mental materna (4,2% explicaram parte da variância no apego materno-fetal. A escolaridade da mãe e do pai não esteve associada a essa variável. O modelo de regressão múltipla considerando os quatro fatores analisados, explicou 8,2% da variância nos escores de apego materno-fetal. Discutem-se as implicações dessas variáveis na formação do vínculo da mãe com o bebê durante a gestação.This study investigated the relations among sociodemographic variables, pregnant women mental health, and maternal-fetal attachment in the third trimester of pregnancy. Participants were 261 pregnant women recruited from public maternity wards using a convenience sampling technique. Each pregnant woman completed a sociodemographic data form, the Maternal-Fetal Attachment Scale, and the SRQ-20. Regression analysis revealed that the number of children (4% and mothers' mental health (4.2% accounted for part of the variance in maternal-fetal attachment scores. Father's and mother's schooling was not associated with this variable. Taking the four analyzed factors into account, a multiple regression model accounted for 8.2% of the variance in the maternal-fetal attachment scores. The implications of these variables for mother-infant bonding during pregnancy are discussed.

  4. Aptidão física relacionada à saúde de escolares de escola pública de tempo integral = Health-related physical fitness of integral time public school students

    Directory of Open Access Journals (Sweden)

    Edson Itaru Kaminagakura

    2010-07-01

    Full Text Available O objetivo do presente estudo é avaliar os níveis de aptidão física relacionada à saúde de crianças de escola pública de tempo integral do município de Ponta Grossa, Estado do Paraná. A amostra constituiu de 104 crianças de 8 a 10 anos de idade, com 47 do sexo masculino e 57 do sexo feminino. A avaliação constituiu da bateria de testes motores PROESP-BR, com ênfase em qualidades físicas relacionadas à saúde como: flexibilidade no teste de sentar e alcançar, aptidão cardiorrespiratória no teste de corrida ou caminhada de nove minutos e resistência muscular localizada através de teste de abdominais. Acomposição corporal foi mensurada utilizando-se o índice de massa corporal (IMC. A amostra apresentou diferenças entre os sexos nos seguintes testes: flexibilidade, na faixa etária de oito anos; abdominal, nos grupos de oito e nove anos; e no teste de 9 minutos, nogrupo de 10 anos. O grupo feminino apresentou maiores características de sobrepeso, quando comparado ao masculino. Não foram verificadas diferenças estatisticamente significativas entre as idades. Os resultados observados não apresentaram níveis satisfatórios de aptidão física relacionada à saúde, revelando um risco aumentado a doenças crônicas não transmissíveis aos escolares.The objective of the present study is to evaluate health-related physical fitness level in children of integral time public school of Ponta Grossa city, in the state of Paraná. The sample constituted of 104 children of 8 to 10 years old, 47 male and 57 female. The evaluation constituted of the PROESP-BR motor test battery, with emphasis in healthrelated physical qualities like: sit-and-reach flexibility test, 9 minutes run or walk cardiorespiratory test and muscular resistance identified through abdominal test. Bodycomposition was assessed utilizing body mass index (BMI. Sample presented differences between sexes in the following tests: flexibility test, in eight age group

  5. Text Comprehension in Chinese Children: Relative Contribution of Verbal Working Memory, Pseudoword Reading, Rapid Automated Naming, and Onset-Rime Phonological Segmentation

    Science.gov (United States)

    Leong, Che Kan; Tse, Shek Kam; Loh, Ka Yee; Hau, Kit Tai

    2008-01-01

    The present study examined the role of verbal working memory (memory span, tongue twister), 2-character Chinese pseudoword reading, rapid automatized naming (letters, numbers), and phonological segmentation (deletion of rimes and onsets) in inferential text comprehension in Chinese in 518 Chinese children in Hong Kong in Grades 3 to 5. It was…

  6. The sooner the better?: An investigation into the role of age of onset and its relation with transfer and exposure in bilingual Frisian-Dutch children

    NARCIS (Netherlands)

    E. Blom; E. Bosma

    2016-01-01

    In this study, age of onset (AoO) was investigated in five- and six-year-old bilingual Frisian-Dutch children. AoO to Dutch ranged between zero and four and had a positive effect on Dutch receptive vocabulary size, but hardly influenced the children's accurate use of Dutch inflection. The influence

  7. The sooner the better? An investigation into the role of age of onset and its relation with transfer and exposure in bilingual Frisian-Dutch children

    NARCIS (Netherlands)

    Blom, W.B.T.; Bosma, E.

    2016-01-01

    In this study, age of onset (AoO) was investigated in five- and six-yearold bilingual Frisian–Dutch children. AoO to Dutch ranged between zero and four and had a positive effect on Dutch receptive vocabulary size, but hardly influenced the children’s accurate use of Dutch inflection. The influence o

  8. Rhizobacterial volatiles and photosynthesis-related signals coordinate MYB72 in Arabidopsis roots during onset of induced systemic resistance and iron deficiency responses

    NARCIS (Netherlands)

    Zamioudis, C.; Korteland, J.; Van Pelt, J.A.; Van Hamersveld, M.; Dombrowski, N.; Bai, Y.; Hanson, J.; Van Verk, M.C.; Ling, H.-Q.; Schulze-Lefert, P.; Pieterse, C.M.J.

    2015-01-01

    In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synth

  9. Planejamento em Saúde

    Directory of Open Access Journals (Sweden)

    Antonio José Costa CARDOSO

    2014-03-01

    Full Text Available Esse texto pretendeu subsidiar aula sobre Planejamento e Avaliação em Saúde para os Analistas Técnicos de Políticas Sociais lotados no Ministério da Saúde (MS, na perspectiva de promover uma maior compreensão dos antecedentes históricos do planejamento em saúde no Brasil e na América Latina, do referencial teórico metodológico do planejamento estratégico e participativo, e refletir sobre os avanços e desafios que se apresentam no atual contexto de construção do Sistema Único de Saúde (SUS. Neste sentido, foi estruturado na perspectiva de responder a três questões orientadoras: 1 Como tem se dado esse processo de coordenação do Planejamento Estratégico Nacional no âmbito do SUS, em cooperação técnica com os Estados, Municípios e Distrito Federal? 2 Quais são as tecnologias de gestão e planejamento em saúde adotadas pelo MS para conduzir esses processos de forma integrada? 3 Como se dá o gerenciamento das ações no MS? Como os planos, projetos e programas são monitorados pelas equipes responsáveis?

  10. An investigation on SA 213-Tube to SA 387-Tube plate using friction welding process

    Energy Technology Data Exchange (ETDEWEB)

    Rajan, S. Pandia; Kumaraswamidhas, L. A. [Indian Institute of Technology, Jharkhand (India); Kumaran, S. Senthil [RVS School of Engineering and Technology, Tamil Nadu (India); Muthukumaran, S. [National Institute of Technology, Tamil Nadu (India)

    2016-01-15

    Friction welding of tube to tube plate using an external tool (FWTPET) is a relatively newer solid state welding process used for joining tube to tube plate of either similar or dissimilar materials with enhanced mechanical and metallurgical properties. In the present study, FWTPET has been used to weld SA 213 (Grade T12) tube with SA 387 (Grade 22) tube plate. The welded samples are found to have satisfactory joint strength and the Energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) study showed that inter metallic compound is absent in the weld zone. The different weld joints have been identified and the phase composition is found using EDX and XRD. Microstructures have been analyzed using optical and Scanning electron microscopy (SEM). The mechanical properties such as hardness, compressive shear strength and peel test for different weld conditions are studied and the hardness survey revealed that there is increase in hardness at the weld interface due to grain refinement. The corrosion behavior for different weld conditions have been analyzed and the weld zone is found to have better corrosion resistance due to the influence of the grain refinement after FWTPET welding process. Hence, the present investigation is carried out to study the behavior of friction welded dissimilar joints of SA 213 tube and SA 387 tube plate joints and the results are presented. The present study confirms that a high quality tube to tube plate joint can be achieved using FWTPET process at 1120 rpm.

  11. A Robust Separation Assurance (SA) Architecture Using Integrated Airborne and Ground SA Concepts Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Intelligent Automation, Inc. proposes a robust SA architecture that uses integrated airborne and ground-based SA concepts such that SA functions are switched between...

  12. A non-invasive, rapid method to genotype late-onset Alzheimer’s disease-related apolipoprotein E gene polymorphisms

    Institute of Scientific and Technical Information of China (English)

    Li Yi; Ting Wu; Wenyuan Luo; Wen Zhou; Jun Wu

    2014-01-01

    The apolipoprotein E geneε4 allele is considered a negative factor for neural regeneration in late-onset Alzheimer’s disease cases. The aim of this study was to establish a non-invasive, rapid method to genotype apolipoprotein E gene polymorphisms. Genomic DNA from mouth swab specimens was extracted using magnetic nanoparticles, and genotyping was performed by real-time PCR using TaqMan-BHQ probes. Genotyping accuracy was validated by DNA se-quencing. Our results demonstrate 100%correlation to DNA sequencing, indicating reliability of our protocol. Thus, the method we have developed for apolipoprotein E genotyping is accurate and reliable, and also suitable for genotyping large samples, which may help determine the role of the apolipoprotein Eε4 allele in neural regeneration in late-onset Alzheimer’s disease cases.

  13. Cerditos Company S.A.

    OpenAIRE

    2010-01-01

    Esta idea de negocio consiste en la adecuación de una granja, en la cual se desarrollará el proceso de levante y comercialización de carne de cerdo en pie o en canal. Cerditos Company S.A. es una empresa que busca la calidad y el buen servicio, brindando al consumidor garantías de la carne que está consumiendo. En Colombia el mercado ha sido poco explotado comparado con otros países como Chile o Europa, donde el consumo es muy significativo, Cerditos Company S.A. busca aumentar el cons...

  14. Symptom onset in autosomal dominant Alzheimer disease

    Science.gov (United States)

    Acosta-Baena, Natalia; Aisen, Paul S.; Bird, Thomas; Danek, Adrian; Fox, Nick C.; Goate, Alison; Frommelt, Peter; Ghetti, Bernardino; Langbaum, Jessica B.S.; Lopera, Francisco; Martins, Ralph; Masters, Colin L.; Mayeux, Richard P.; McDade, Eric; Moreno, Sonia; Reiman, Eric M.; Ringman, John M.; Salloway, Steve; Schofield, Peter R.; Sperling, Reisa; Tariot, Pierre N.; Xiong, Chengjie; Morris, John C.; Bateman, Randall J.

    2014-01-01

    Objective: To identify factors influencing age at symptom onset and disease course in autosomal dominant Alzheimer disease (ADAD), and develop evidence-based criteria for predicting symptom onset in ADAD. Methods: We have collected individual-level data on ages at symptom onset and death from 387 ADAD pedigrees, compiled from 137 peer-reviewed publications, the Dominantly Inherited Alzheimer Network (DIAN) database, and 2 large kindreds of Colombian (PSEN1 E280A) and Volga German (PSEN2 N141I) ancestry. Our combined dataset includes 3,275 individuals, of whom 1,307 were affected by ADAD with known age at symptom onset. We assessed the relative contributions of several factors in influencing age at onset, including parental age at onset, age at onset by mutation type and family, and APOE genotype and sex. We additionally performed survival analysis using data on symptom onset collected from 183 ADAD mutation carriers followed longitudinally in the DIAN Study. Results: We report summary statistics on age at onset and disease course for 174 ADAD mutations, and discover strong and highly significant (p 0.38) correlations between individual age at symptom onset and predicted values based on parental age at onset and mean ages at onset by mutation type and family, which persist after controlling for APOE genotype and sex. Conclusions: Significant proportions of the observed variance in age at symptom onset in ADAD can be explained by family history and mutation type, providing empirical support for use of these data to estimate onset in clinical research. PMID:24928124

  15. The Sooner the Better? An Investigation into the Role of Age of Onset and Its Relation with Transfer and Exposure in Bilingual Frisian-Dutch Children

    Science.gov (United States)

    Blom, Elma; Bosma, Evelyn

    2016-01-01

    In this study, age of onset (AoO) was investigated in five- and six-year-old bilingual Frisian-Dutch children. AoO to Dutch ranged between zero and four and had a positive effect on Dutch receptive vocabulary size, but hardly influenced the children's accurate use of Dutch inflection. The influence of AoO on vocabulary was more prominent than the…

  16. Rhizobacterial volatiles and photosynthesis-related signals coordinate MYB72 expression in Arabidopsis roots during onset of induced systemic resistance and iron-deficiency responses

    OpenAIRE

    Zamioudis, Christos; Korteland, Jolanda; van Pelt, Johan A.; van Hamersveld, Muriël; Dombrowski, Nina; Bai, Yang; Hanson, Johannes; van Verk, Marcel C.; Ling, Hong-Qing; Schulze-Lefert, Paul; Pieterse, Corné M. J.

    2015-01-01

    In Arabidopsis roots, the transcription factor MYB72 plays a dual role in the onset of rhizobacteria-induced systemic resistance (ISR) and plant survival under conditions of limited iron availability. Previously, it was shown that MYB72 coordinates the expression of a gene module that promotes synthesis and excretion of iron-mobilizing phenolic compounds in the rhizosphere, a process that is involved in both iron acquisition and ISR signaling. Here, we show that volatile organic compounds (VO...

  17. Reduction in IgG galactose in juvenile and adult onset rheumatoid arthritis measured by a lectin binding method and its relation to rheumatoid factor.

    OpenAIRE

    1991-01-01

    Glycosylation changes in patients with juvenile chronic and adult onset rheumatoid arthritis have been studied using a novel binding method. Both these major types of arthritis showed decreased galactosylation of serum IgG, which confirms earlier studies using a different, more complex chemical method. No significant correlation between serum IgG, IgM, and IgA rheumatoid factors and age corrected G(o) (percentage of oligosaccharide chains lacking galactose) was found. The possibility that the...

  18. A produção do conhecimento da saúde pública sobre a relação homem-saúde: uma revisão bibliográfica Public health research output related to males and health: a bibliographical review

    Directory of Open Access Journals (Sweden)

    Romeu Gomes

    2006-05-01

    Full Text Available O estudo tem como objetivo analisar a produção bibliográfica sobre a relação homem-saúde, no campo da saúde pública. A partir dessa análise, pretende-se problematizar as idéias mais recorrentes nas considerações sobre as especificidades do ser homem no processo saúde-doença. O método consistiu-se numa revisão bibliográfica de artigos de saúde pública, realizada a partir de uma abordagem de pesquisa qualitativa. Sexualidade masculina, masculinidade e reprodução e masculinidade e poder foram os temas encontrados na análise. Concluiu-se que ainda são necessárias investigações sobre as masculinidades relacionadas a gênero, nacionalidade, classe, idade, etnia e orientação sexual.This study focuses on the research output in the relationship between males and health in the public health field. The objective is to critically analyze the most recurrent ideas on the specificities of maleness in the health-disease process. The method consisted of a literature review in public health, based on a qualitative research approach. Male sexuality, masculinity, and reproduction and masculinity and power were the themes found in the analysis. The study concludes that further research on masculinity is needed with a focus on gender, nationality, class, age, ethnicity, and sexual orientation.

  19. Qualidade de vida relacionada à saúde de filhos de profissionais da área de saúde Calidad de vida relacionada a la salud de los hijos de profesionales del área de salud Health-related quality of life of the children of health professionals

    Directory of Open Access Journals (Sweden)

    Silvia Maria Moussi Gamallo

    2012-12-01

    Full Text Available Neste estudo mensuramos a qualidade de vida relacionada à saúde (QVRS e a fadiga de filhos de profissionais da área da saúde, com idades entre 2 e 11 anos, e avaliamos os hábitos diários e o sono dessas crianças e dos respectivos pais. Foram incluídas no estudo crianças de uma escola pública. Dados demográficos e dados de hábitos diários foram colhidos. A QVRS, o sono e a fadiga foram mensurados por questionários. Participaram 249 pais - 63,5% referiram sono adequado e 47,4% acordavam cansados. A média da idade das crianças foi 5,6 anos - 62,2% assistiam televisão no quarto, 50% usavam computador (> 4 horas/dia e 27,8% faziam atividades físicas extracurriculares. O escore do sono foi de 45,8 ± 12,2. Os escores de QVRS foram mais elevados no aspecto físico e mais baixos no emocional. Detectamos que o sono de pior qualidade dos filhos e dos pais pode estar relacionado à pior QVRS dos filhos. Concluímos que os hábitos inadequados dos pais, bem como das crianças, estão relacionados a uma diminuição da QVRS dos filhos, especialmente no aspecto emocional.Se mensuró la calidad de vida relacionada a la salud (QVRS, fatiga y se evaluaron hábitos diarios y de sueño de hijos de profesionales del área de salud, con entre 2 y 11 años de edad, y sus padres. Recolectados datos demográficos y de hábitos diarios. La QVRS, sueño y fatiga se midieron mediante cuestionarios. Participaron 249 padres, 63,5% refirió sueño adecuado, 47,4% despertaba cansado. Media etaria de niños de 5,6 años; 62,2% veían televisión en su cuarto, 50% utilizaba computador (>4 horas diarias, 27,8% realizaba actividad física extracurricular. Su puntaje de sueño fue 45,8 ± 12,2. Puntajes de QVRS más elevados en aspecto físico y menores en aspecto emocional. El sueño de peor calidad de padres e hijos puede relacionarse con peor QVRS de los hijos. Concluimos en que los hábitos inadecuados de padres e hijos se relacionan con una disminución de

  20. Late onset clozapine induced agranulocytosis

    Directory of Open Access Journals (Sweden)

    Rajmohan Velayudhan

    2014-01-01

    Full Text Available Agranulocytosis is defined as an absolute neutrophil count less than 100/mm 3 in association with infectious disease. The risk of agranulocytosis is 0.38% of all clozapine treated cases and there is a relatively lesser incidence in Indian population. The risk of clozapine-induced agranulocytosis and neutropenia is highest in the first 6 months and higher in the initial 18 months after the onset of treatment. There have been very few reports of neutropenia and agranulocytosis after this period. There have so far been no reports of late onset clozapine induced agranulocytosis has been reported from India. A case of late onset clozapine induced agranulocytosis with possible mechanism of the same is reported.

  1. A novel onset detection technique for brain-computer interfaces using sound-production related cognitive tasks in simulated-online system

    Science.gov (United States)

    Song, YoungJae; Sepulveda, Francisco

    2017-02-01

    Objective. Self-paced EEG-based BCIs (SP-BCIs) have traditionally been avoided due to two sources of uncertainty: (1) precisely when an intentional command is sent by the brain, i.e., the command onset detection problem, and (2) how different the intentional command is when compared to non-specific (or idle) states. Performance evaluation is also a problem and there are no suitable standard metrics available. In this paper we attempted to tackle these issues. Approach. Self-paced covert sound-production cognitive tasks (i.e., high pitch and siren-like sounds) were used to distinguish between intentional commands (IC) and idle states. The IC states were chosen for their ease of execution and negligible overlap with common cognitive states. Band power and a digital wavelet transform were used for feature extraction, and the Davies-Bouldin index was used for feature selection. Classification was performed using linear discriminant analysis. Main results. Performance was evaluated under offline and simulated-online conditions. For the latter, a performance score called true-false-positive (TFP) rate, ranging from 0 (poor) to 100 (perfect), was created to take into account both classification performance and onset timing errors. Averaging the results from the best performing IC task for all seven participants, an 77.7% true-positive (TP) rate was achieved in offline testing. For simulated-online analysis the best IC average TFP score was 76.67% (87.61% TP rate, 4.05% false-positive rate). Significance. Results were promising when compared to previous IC onset detection studies using motor imagery, in which best TP rates were reported as 72.0% and 79.7%, and which, crucially, did not take timing errors into account. Moreover, based on our literature review, there is no previous covert sound-production onset detection system for spBCIs. Results showed that the proposed onset detection technique and TFP performance metric have good potential for use in SP-BCIs.

  2. Relações entre a saúde mental da gestante e o apego materno-fetal Relations between pregnant women's mental health and maternal-fetal attachment

    OpenAIRE

    Patrícia Alvarenga; Maria Virgínia Machado Dazzani; Cristiane Ajnamei dos Santos Alfaya; Eulina da Rocha Lordelo; César Augusto Piccinini

    2012-01-01

    O estudo investigou as relações entre variáveis sociodemográficas, saúde mental da gestante e o apego materno-fetal no terceiro trimestre de gestação. Participaram do estudo 261 gestantes selecionadas através de amostragem por acessibilidade em quatro maternidades públicas. As gestantes responderam individualmente uma ficha de dados sociodemográficos, a Escala de Apego Materno-Fetal e o SRQ-20. A análise de regressão revelou que o número de filhos (4%) e a saúde mental materna (4,2%) explicar...

  3. Relatives Education And Coping Toolkit - REACT. Study protocol of a randomised controlled trial to assess the feasibility and effectiveness of a supported self management package for relatives of people with recent onset psychosis

    Directory of Open Access Journals (Sweden)

    Dunn Graham

    2011-06-01

    Full Text Available Abstract Background Mental health problems commonly begin in adolescence when the majority of people are living with family. This can be a frightening time for relatives who often have little knowledge of what is happening or how to manage it. The UK National Health Service has a commitment to support relatives in order to reduce their distress, but research studies have shown that this can lead to a better outcome for service users as well. Unfortunately, many relatives do not get the kind of support they need. We aim to evaluate the feasibility, acceptability and effectiveness of providing and supporting a Relatives' Education and Coping Toolkit (REACT for relatives of people with recent onset psychosis. Methods The study is a randomised control trial. Trial Registration for Current Controlled Trials ISRCTN69299093. Relatives of people receiving treatment from the Early Intervention Service for psychosis are randomly allocated to receive either Treatment As Usual (TAU or TAU plus the REACT intervention. The main aims of the study are to: (i determine the acceptability of a supported self-management intervention; (ii determine preference for type of support; (iii assess the feasibility of the design; (iv identify the barriers and solutions to offering support for self-management approaches within the NHS; (v estimate the likely effect size of the impact of the intervention on outcome for relatives; (vi gain detailed feedback about the barriers and solutions to using a self-management approach; (vii describe the way in which the intervention is used. Outcomes will be assessed from baseline and at 6 month follow-up. Discussion The intervention is compared to current treatment in a sample of participants highly representative of relatives in routine early intervention services across the UK. The intervention is protocolised, offered within routine practice by existing staff and extensive process data is being collected. Randomisation is

  4. Relatives Education And Coping Toolkit - REACT. Study protocol of a randomised controlled trial to assess the feasibility and effectiveness of a supported self management package for relatives of people with recent onset psychosis

    Science.gov (United States)

    2011-01-01

    Background Mental health problems commonly begin in adolescence when the majority of people are living with family. This can be a frightening time for relatives who often have little knowledge of what is happening or how to manage it. The UK National Health Service has a commitment to support relatives in order to reduce their distress, but research studies have shown that this can lead to a better outcome for service users as well. Unfortunately, many relatives do not get the kind of support they need. We aim to evaluate the feasibility, acceptability and effectiveness of providing and supporting a Relatives' Education and Coping Toolkit (REACT) for relatives of people with recent onset psychosis. Methods The study is a randomised control trial. Trial Registration for Current Controlled Trials ISRCTN69299093. Relatives of people receiving treatment from the Early Intervention Service for psychosis are randomly allocated to receive either Treatment As Usual (TAU) or TAU plus the REACT intervention. The main aims of the study are to: (i) determine the acceptability of a supported self-management intervention; (ii) determine preference for type of support; (iii) assess the feasibility of the design; (iv) identify the barriers and solutions to offering support for self-management approaches within the NHS; (v) estimate the likely effect size of the impact of the intervention on outcome for relatives; (vi) gain detailed feedback about the barriers and solutions to using a self-management approach; (vii) describe the way in which the intervention is used. Outcomes will be assessed from baseline and at 6 month follow-up. Discussion The intervention is compared to current treatment in a sample of participants highly representative of relatives in routine early intervention services across the UK. The intervention is protocolised, offered within routine practice by existing staff and extensive process data is being collected. Randomisation is independent; all assessments

  5. Relatives Education And Coping Toolkit--REACT. Study protocol of a randomised controlled trial to assess the feasibility and effectiveness of a supported self management package for relatives of people with recent onset psychosis.

    Science.gov (United States)

    Lobban, Fiona; Glentworth, David; Wainwright, Laura; Pinfold, Vanessa; Chapman, Lesley; Larkin, Warren; Dunn, Graham; Postlethwaite, Adam; Haddock, Gillian

    2011-06-16

    Mental health problems commonly begin in adolescence when the majority of people are living with family. This can be a frightening time for relatives who often have little knowledge of what is happening or how to manage it. The UK National Health Service has a commitment to support relatives in order to reduce their distress, but research studies have shown that this can lead to a better outcome for service users as well. Unfortunately, many relatives do not get the kind of support they need. We aim to evaluate the feasibility, acceptability and effectiveness of providing and supporting a Relatives' Education and Coping Toolkit (REACT) for relatives of people with recent onset psychosis. The study is a randomised control trial. Trial Registration for Current Controlled Trials ISRCTN69299093. Relatives of people receiving treatment from the Early Intervention Service for psychosis are randomly allocated to receive either Treatment As Usual (TAU) or TAU plus the REACT intervention. The main aims of the study are to: (i) determine the acceptability of a supported self-management intervention; (ii) determine preference for type of support; (iii) assess the feasibility of the design; (iv) identify the barriers and solutions to offering support for self-management approaches within the NHS; (v) estimate the likely effect size of the impact of the intervention on outcome for relatives; (vi) gain detailed feedback about the barriers and solutions to using a self-management approach; (vii) describe the way in which the intervention is used. Outcomes will be assessed from baseline and at 6 month follow-up. The intervention is compared to current treatment in a sample of participants highly representative of relatives in routine early intervention services across the UK. The intervention is protocolised, offered within routine practice by existing staff and extensive process data is being collected. Randomisation is independent; all assessments are made by blind raters. The

  6. Baixos níveis de aptidão física relacionada à saúde em universitários Low levels of health-related physical fitness among university students

    Directory of Open Access Journals (Sweden)

    Maruí Weber Corseuil

    2010-03-01

    Full Text Available Este estudo teve por objetivo identificar a prevalência de baixos níveis de aptidão física relacionada à saúde em universitários, quanto aos componentes músculo-esqueléticos (motores. Participaram da amostra 234 estudantes (112 moças e 122 rapazes, entre 17 e 29 anos, matriculados em diversos cursos da Universidade Federal de Santa Catarina. Foi utilizada uma bateria de testes proposta pela Sociedade Canadense de Fisiologia do Exercício. Os testes propostos foram: força de preensão manual; extensão dos braços; flexão do tronco; impulsão vertical; resistência abdominal e força dorsal. Os resultados apontam uma prevalência de aptidão física abaixo dos indicadores recomendados à saúde de 16,6% (13,4% feminino e 19,6% masculino. Especificamente, observaram-se os seguintes índices de prevalência de universitários que não atingiram os critérios recomendados: 69,2% para a potência de membros inferiores, 62% para extensão de braços, 38,4% para a preensão manual, 13,2% para flexão de tronco, 11,1% para força dorsal e 10,7% para força abdominal. Em se tratando de indivíduos jovens, observou-se que boa parte dos universitários encontra-se com baixos níveis de aptidão física, sugerindo a importância da implantação de programas para o desenvolvimento e/ou manutenção da aptidão física destes estudantes, fornecendo subsídios para que estes adotem um estilo de vida mais ativo e saudável por toda a sua vidaThe aim of this study was to identify the prevalence of low health-related physical fitness levels among university students in terms of muscle-skeletal components (motor performance. A total of 234 students (112 girls and 122 boys aged 17 to 29 years, enrolled in different courses of the Federal University of Santa Catarina, Brazil, participated in the study. The test battery proposed by the Canadian Society for Exercise Physiology was used: handgrip strength, push-ups, sit and reach, vertical jump, partial

  7. Early Onset Werner Syndrome

    Directory of Open Access Journals (Sweden)

    Berna İmge Aydoğan

    2015-09-01

    Full Text Available Werner syndrome (WS is a rare autosomal recessive adult-onset progeroid disorder characterized by the early onset of aged-appearance and age-related metabolic disorders. Symptoms of premature aging usually first develop in the second-third decades of life. We report a 27-year-old female who was admitted to our clinic at the age of eighteen with hyperglycemia. She was diagnosed with diabetes and type 4 dyslipidemia at the age of seven. In her family history, her parents were first cousins and she had three healthy brothers. On her first physical examination; she had bird-like face appearance, global hair loss, beaked nose, short stature and she was overweight. She had global hair loss with gray and thin hair. Hoarseness of voice and hyperkeratosis of skin were observed. She had bilateral cataracts and moderate sensorineural hearing loss. On psychiatric examination, borderline mental retardation was detected. She had severe insulin resistance and hypertriglyceridemia despite levothyroxine, gemfibrozil, omega-3 and intensive insulin treatment. Routine lipid apheresis was performed to lower the triglyceride levels reaching 5256 mg/dL. She also had focal segmental glomerulosclerosis, hepatosteatosis, osteoporosis and epilepsy. Disease was accompanied by several congenital deformities, such as Rathke’s cleft cyst, angiomyolipoma and femoral neck hypoplasia. WS is a rare genetic disorder characterized by multiple endocrine manifestations as well as soft tissue changes. We present a case of early disturbances that were diagnosed before typical clinical signs and symptoms. We propose that WS should be kept in mind when type 2 diabetes and hyperlipidemia are diagnosed early in childhood. Turk Jem 2015; 19: 99-104

  8. ANALISIS DAYA SAING KEDELAI INDONESIA

    Directory of Open Access Journals (Sweden)

    Sarwono Sarwono

    2014-09-01

    Full Text Available RCA (Revealed Comparative Advantage index of soybean in Indonesia from 1983 up to 2013 is less than one, mostly. It means that the competitiveness of soybean in Indonesia is low. The purpose of this study is to analyze the factors influence the soybean competitiveness. OLS (Ordinary Least Square was used as the analysis method. Hypotheses test based on that analysis model is not bias, so that, classic divergence test is needed. It is for getting the Best Linier Unbiased Estimator (BLUE appraisal. T statistic and F statistic were also applied. The result of this research shows that production and export have positive and significant influence. In addition, exchange rate and government policy do not influence the Indonesia soybean competitiveness.Indeks RCA (Revealed Comparative Advantage kedelai Indonesia dari tahun 1983-2013 kecenderungan bernilai kurang dari satu yang berarti daya saing kedelai Indonesia rendah.Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi daya saing kedelai Indonesia.Metode analisis yang digunakan adalah Ordinary Least Square (OLS.Pengujian hipotesis berdasarkan model analisis tersebut tidak bias maka perlu dilakukan uji penyimpangan klasik yang tujuannya agar diperoleh penaksiran yang bersifat Best Linier Unbiased Estimator (BLUE.Pengujian statistik menggunakan uji t statistikdan uji f statistik.Hasil penelitian ini menunjukkan bahwa produksi dan ekspor berpengaruh secara positif dan signifikan terhadap daya saing kedelai Indonesia. Nilai tukar rupiah dan kebijakan pemerintah tidak berpengaruh terhadap daya saing kedelai Indonesia.

  9. Saúde e desenvolvimento

    Directory of Open Access Journals (Sweden)

    Ana Luiza D'Ávila Viana

    Full Text Available Considerando que os modernos sistemas de saúde são o resultado da complexa interação de processos econômicos, políticos e sociais, o objetivo do trabalho é discutir a relação entre saúde e desenvolvimento no Brasil, mostrando que o esgotamento do modelo liberal de política econômica abre nova perspectiva para a retomada do desenvolvimento, entendido como combinação entre crescimento da economia, mudanças na estrutura produtiva e melhora das condições de vida da população. O complexo produtivo da saúde joga papel decisivo nesse processo, pois constitui um campo em que inovação tecnológica e acumulação de capital geram oportunidades de investimento, trabalho e renda, além de produzir avanços importantes para melhorar o estado de saúde das pessoas. A recente adoção de políticas públicas voltadas para articular, de forma positiva, aspectos da política econômica e da política social revela que a questão do desenvolvimento nacional ganhou nova centralidade na agenda governamental, o que abre a perspectiva de maior integração entre a lógica econômica e a lógica sanitária. Entretanto, é preciso reconhecer que o Brasil ainda não logrou alcançar uma associação virtuosa entre saúde e desenvolvimento.

  10. Superior oblique tendon (Brown’s syndrome as the presenting finding in childhood onset HLA-B27-related enthesitis and juvenile idiopathic oligoarticular arthritis

    Directory of Open Access Journals (Sweden)

    C. Pham

    2014-11-01

    Full Text Available We report two patients who presented with Brown’s syndrome. The first is a 7-year-old boy who at the time of his diagnosis was also found to have enthesitis and HLA-B27 positivity. The second patient was diagnosed with bilateral Brown’s syndrome at 13 months of age. At age 7 she developed a persistent oligoarticular arthritis and unilateral anterior iritis consistent with the oligoarticular Juvenile Idiopatic Arthritis (JIA phenotype. These cases highlight ophthalmologic findings and diagnostic considerations with respect to Brown’s syndrome and associated childhood onset rheumatologic disease.

  11. Reduction in IgG galactose in juvenile and adult onset rheumatoid arthritis measured by a lectin binding method and its relation to rheumatoid factor.

    Science.gov (United States)

    Sumar, N; Isenberg, D A; Bodman, K B; Soltys, A; Young, A; Leak, A M; Round, J; Hay, F C; Roitt, I M

    1991-09-01

    Glycosylation changes in patients with juvenile chronic and adult onset rheumatoid arthritis have been studied using a novel binding method. Both these major types of arthritis showed decreased galactosylation of serum IgG, which confirms earlier studies using a different, more complex chemical method. No significant correlation between serum IgG, IgM, and IgA rheumatoid factors and age corrected G(o) (percentage of oligosaccharide chains lacking galactose) was found. The possibility that the less glycosylated IgG is preferentially confined to circulating IgM/IgG immune complexes cannot be excluded, however.

  12. Lacunas e falhas relacionadas à importação de produtos para a saúde em contêiner | Breaches and errors related to imports of health products in containers

    Directory of Open Access Journals (Sweden)

    Mariene Castilho D’Ávila

    2016-08-01

    Full Text Available Metade das mercadorias relacionadas à saúde, importadas via Porto do Rio de Janeiro, é armazenada em contêineres, 70% deles não possui sistema de refrigeração, por isto, não é possível assegurar a manutenção das recomendações do fabricante conforme exigem as regulamentações sanitárias estabelecidas. Estes contêineres geralmente são fabricados em aço, suas especificações são voltadas para possibilitar segurança e eficiência no transporte de mercadorias diversas e estão inseridos em um complexo contexto multimodal. O presente estudo objetivou obter conhecimento sobre este segmento de importação, na produção científica, legislação internacional, orientações técnicas e práticas operacionais atuais. As análises realizadas entre 2014 e 2015 revelaram que os contêineres são sensíveis ao ambiente em que estão depositados, 30% das medições apresentaram discrepâncias em relação às recomendações de temperatura para a armazenagem. Foram registradas temperaturas acima de 60°C. A exposição das mercadorias a estas condições foi estimada em no mínimo 38 dias. Não foram localizados estudos científicos sobre o acondicionamento de mercadorias para a saúde em contêineres. As produções técnica e legal são incipientes. Esses resultados reforçam a preocupação com a eficácia das mercadorias importadas e a necessidade de se promover o debate sobre a armazenagem em contêineres onde se estabeleçam requisitos mínimos de qualidade obrigatórios. ===================================================== Half of the health products imported through the Port of Rio de Janeiro are stored in containers. As 70% of these containers do not have refrigeration system, manufacturer’s recommendations –as required by health regulations- cannot be guaranteed. Containers are usually made of steel, aim to enable safe and efficient transportation of various goods, and are embedded in a complex multi-modal system. This

  13. Cutaneous warming promotes sleep onset.

    Science.gov (United States)

    Raymann, Roy J E M; Swaab, Dick F; Van Someren, Eus J W

    2005-06-01

    Sleep occurs in close relation to changes in body temperature. Both the monophasic sleep period in humans and the polyphasic sleep periods in rodents tend to be initiated when core body temperature is declining. This decline is mainly due to an increase in skin blood flow and consequently skin warming and heat loss. We have proposed that these intrinsically occurring changes in core and skin temperatures could modulate neuronal activity in sleep-regulating brain areas (Van Someren EJW, Chronobiol Int 17: 313-54, 2000). We here provide results compatible with this hypothesis. We obtained 144 sleep-onset latencies while directly manipulating core and skin temperatures within the comfortable range in eight healthy subjects under controlled conditions. The induction of a proximal skin temperature difference of only 0.78 +/- 0.03 degrees C (mean +/- SE) around a mean of 35.13 +/- 0.11 degrees C changed sleep-onset latency by 26%, i.e., by 3.09 minutes [95% confidence interval (CI), 1.91 to 4.28] around a mean of 11.85 min (CI, 9.74 to 14.41), with faster sleep onsets when the proximal skin was warmed. The reduction in sleep-onset latency occurred despite a small but significant decrease in subjective comfort during proximal skin warming. The induction of changes in core temperature (delta = 0.20 +/- 0.02 degrees C) and distal skin temperature (delta = 0.74 +/- 0.05 degrees C) were ineffective. Previous studies have demonstrated correlations between skin temperature and sleep-onset latency. Also, sleep disruption by ambient temperatures that activate thermoregulatory defense mechanisms has been shown. The present study is the first to experimentally demonstrate a causal contribution to sleep-onset latency of skin temperature manipulations within the normal nocturnal fluctuation range. Circadian and sleep-appetitive behavior-induced variations in skin temperature might act as an input signal to sleep-regulating systems.

  14. Event-related potentials to tones show differences between children with multiple risk factors for dyslexia and control children before the onset of formal reading instruction.

    Science.gov (United States)

    Hämäläinen, Jarmo A; Lohvansuu, Kaisa; Ervast, Leena; Leppänen, Paavo H T

    2015-02-01

    Multiple risk factors can affect the development of specific reading problems or dyslexia. In addition to the most prevalent and studied risk factor, phonological processing, auditory discrimination problems have also been found in children and adults with reading difficulties. The present study examined 37 children between the ages of 5 and 6, 11 of which had multiple risk factors for developing reading problems. The children participated in a passive oddball EEG experiment with sinusoidal sounds with changes in sound frequency, duration, or intensity. The responses to the standard stimuli showed a negative voltage shift in children at risk for reading problems compared to control children at 107-215 ms in frontocentral areas corresponding to P1 offset and N250 onset. Source analyses showed that the difference originated from the left and right auditory cortices. Additionally, the children at risk for reading problems had a larger late discriminative negativity (LDN) response in amplitude for sound frequency change than the control children. The amplitudes at the P1-N250 time window showed correlations to letter knowledge and phonological identification whereas the amplitudes at the LDN time window correlated with verbal short-term memory and rapid naming. These results support the view that problems in basic auditory processing abilities precede the onset of reading instruction and can act as one of the risk factors for dyslexia.

  15. A construção do significado de controle social com conselheiros de saúde no Estado do Piauí, Brasil Construction of meanings relating to social control with health counselors in Piauí state, Brazil

    Directory of Open Access Journals (Sweden)

    José Ivo dos Santos Pedrosa

    1997-10-01

    Full Text Available Descrição de uma experiência de intervenção pedagógica junto aos conselheiros de saúde de duas Diretorias Regionais de Saúde do Estado do Piauí. Valendo-se do projeto de Incentivo ao Controle Social e à Participação Popular na Construção do SUS, do Ministério da Saúde, o artigo analisa as formas e conteúdos da questão do controle social em saúde, numa situação em que o controle político e econômico da sociedade é exercido por pequenos grupos donos do poder e da riqueza, que configuram o padrão oligárquico de dominação. Neste sentido, a experiência demonstrou a importância da construção coletiva do significado de controle social com bases nas relações cotidianas entre a comunidade e os serviços de saúde e o papel estratégico do profissional ao desenvolver estas ações.This article describes a health education experiment with health counselors in two health administration districts in the State of Piaui, Brazil. Focusing on the Ministry of Health's Project for Social Control and People's Participation in Health, the article analyzes forms and contents pertaining to the issue of social control in the health field, under a situation where society is controlled by small groups detaining both power and wealth. The experiment showed the importance of constructing meanings concerning social control in day-to-day relationships between the community and health services and the strategic role of health professionals in developing health education activities.

  16. Varyasyong Leksikal sa mga Dayalektong Mandaya

    Directory of Open Access Journals (Sweden)

    Dr. Raymund M. Pasion

    2014-12-01

    Full Text Available Layuning panlahat sa pag-aaral na ito na tuklasin ang varyasyong leksikalsa Wikang Mandaya na matatagpuan sa Probinsyang Davao Oriental. Bilang lunsaran sa paglilikom ng mga datos, ginamit ang mga terminong kultural na pangkabuhayan tulad ng pagsasaka, pangangaso, pangingisda at paghahayupan nanababatay sa Indigenous Knowledge System and Practices (IKSP.Sinikap sagutin sa pagaaral ang suliraning ano-anong varyasyong liksikal ang makikita sa mga terminong kultural na pangkabuhayan ng Mandaya na makikita sa munisipalidad ng Caraga, Manay, Bagangaat Cateel? Disenyong kwalitatibo ginamit.Metodong indehinusat deskriptibo naman ang ginamit mula sa paglilikom hanggang sa pag-aanalisa ng mga datos. Samantalang, ang mga impormante ay pinilisa pamamagitan ng kombinasyong purposive at snow-ball sampling. Natuklasan, na ang wikang Mandaya ay nakitaan ng varyasyong lekisikal ayon sa magkakaiba ang anyo, may pagkakatulad ang anyo, at magkakatulad ang anyo subalit magkakaiba ang bigkas. Gayunpaman, pinaniniwalaang dahil sa paktor na heograpikal, sikolohikal at sosyolohikal na nagaganap sa kanilang kultura ay hindi rin maipagkailang nagyari ang varyasyong leksikal na aspekto nito.

  17. Autopercepção corporal de variáveis da aptidão física relacionada à saúde Bodily self-perception of health-related physical fitness variables

    Directory of Open Access Journals (Sweden)

    Denise Sardinha Mendes Soares de Araújo

    2002-04-01

    Full Text Available FUNDAMENTAÇÃO: A aptidão física apresenta duas dimensões, uma relacionada à saúde e outra ao desempenho. Não é sabido se adultos não-atletas possuem autopercepção corporal (ApC apropriada sobre a sua aptidão física relacionada à saúde. OBJETIVOS: a testar a ApC de indivíduos não-atletas em algumas variáveis morfofuncionais constituintes da aptidão física, b verificar se a margem de acerto ou de erro nessa ApC depende dos resultados obtidos; e c verificar se aqueles com maior ApC são mais aptos fisicamente. MÉTODOS: Foram obtidos dados em 63 adultos (51 homens, com idade entre 22 e 85 anos, tendo sido medida e testada a ApC das seguintes variáveis: VO2 máximo, flexibilidade, força de preensão manual, potência muscular máxima absoluta e relativa, localização predominante de gordura corporal e peso de referência, habilidade de sentar e levantar do solo e relação peso/altura, além da altura e do peso corporal. A influência da magnitude das variáveis sobre o escore de ApC (soma dos acertos nas 12 variáveis testadas foi testada pela comparação entre os resultados do primeiro e do quinto quintis da distribuição e por correlações. RESULTADOS: Os indivíduos tendem a errar mais do que a acertar, em média, a ApC: 60 vs. 40%. A ApC é mais incorreta para a variável flexibilidade 84% de erro - e mais precisa para a habilidade de levantar do solo 66% de acerto. O escore de ApC foi maior nos indivíduos mais flexíveis (p = 0,01 e nos que possuíam maior força de preensão manual (p = 0,04 e tendia a ser maior nos que alcançavam percentual mais elevado do VO2 máximo previsto (p = 0,08. O sedentarismo era quase três vezes mais prevalente nos indivíduos com pior ApC. Os 20% com maiores escores de ApC tendiam a melhores resultados nas variáveis da aptidão física (p entre 0,03 e 0,11. CONCLUSÕES: O nível global de ApC de variáveis da aptidão física é baixo, dependendo dos níveis de flexibilidade e de

  18. Ciência, técnica e cultura: relações entre risco e práticas de saúde Science, technique, and culture: relations between risk and health practices

    Directory of Open Access Journals (Sweden)

    Dina Czeresnia

    2004-04-01

    Full Text Available Este artigo tem como objetivo discutir conseqüências culturais dos discursos e práticas voltados à capacitação dos sujeitos para a escolha racional e informada de riscos, calculados com base no conhecimento científico. O conceito de risco epidemiológico é um dos elementos centrais deste processo, especialmente no contexto das práticas de saúde. Inicialmente é apresentada uma breve caracterização do conceito de risco epidemiológico, ressaltando que, como modelo abstrato, reduz a complexidade dos fenômenos que estuda. A apreensão da realidade mediante essa abstração gera valores e significados. A reflexão de Canguilhem sobre as relações entre ciência, técnica e vida é retomada com a perspectiva de aprofundar a compreensão das conseqüências culturais produzidas, que contribuem para a transformação das concepções clássicas de individualidade, autonomia e sociabilidade. Temas vitais cruciais, como individualidade, alteridade, relação com a morte, estão presentes (ocultos nas questões que envolvem a nuclearidade do risco no mundo atual.This article discusses the cultural consequences of discourses and practices aimed at training subjects for a rational, informed choice in relation to risks, calculated on the basis of scientific knowledge. The epidemiological risk concept is a central element in this process, especially in the context of health practices. The article begins by briefly characterizing the epidemiological risk concept, emphasizing that as an abstract model, it reduces the complexity of the phenomena it studies. Grasping reality through this abstraction generates values and meanings. Canguilhem's reflection on the relations between science, technique, and life is further discussed from the perspective of deepening an understanding of the cultural consequences of this process, contributing to the transformation of classical concepts of individuality, autonomy, and sociability. Such vital themes as

  19. MimoSA: a system for minimotif annotation

    Directory of Open Access Journals (Sweden)

    Kundeti Vamsi

    2010-06-01

    Full Text Available Abstract Background Minimotifs are short peptide sequences within one protein, which are recognized by other proteins or molecules. While there are now several minimotif databases, they are incomplete. There are reports of many minimotifs in the primary literature, which have yet to be annotated, while entirely novel minimotifs continue to be published on a weekly basis. Our recently proposed function and sequence syntax for minimotifs enables us to build a general tool that will facilitate structured annotation and management of minimotif data from the biomedical literature. Results We have built the MimoSA application for minimotif annotation. The application supports management of the Minimotif Miner database, literature tracking, and annotation of new minimotifs. MimoSA enables the visualization, organization, selection and editing functions of minimotifs and their attributes in the MnM database. For the literature components, Mimosa provides paper status tracking and scoring of papers for annotation through a freely available machine learning approach, which is based on word correlation. The paper scoring algorithm is also available as a separate program, TextMine. Form-driven annotation of minimotif attributes enables entry of new minimotifs into the MnM database. Several supporting features increase the efficiency of annotation. The layered architecture of MimoSA allows for extensibility by separating the functions of paper scoring, minimotif visualization, and database management. MimoSA is readily adaptable to other annotation efforts that manually curate literature into a MySQL database. Conclusions MimoSA is an extensible application that facilitates minimotif annotation and integrates with the Minimotif Miner database. We have built MimoSA as an application that integrates dynamic abstract scoring with a high performance relational model of minimotif syntax. MimoSA's TextMine, an efficient paper-scoring algorithm, can be used to

  20. Caracterização das infecções relacionadas à assistência à saúde em uma Unidade de Terapia Intensiva | Description of Infections Related to Health Care (IRAS of patients in an Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Francisco Gilberto Fernandes Pereira

    2016-02-01

    Full Text Available Objetivo: Analisar as Infecções Relacionadas à Assistência à Saúde (IRAS de pacientes em Unidade de Terapia Intensiva. Método: Estudo epidemiológico, retrospectivo, realizado em Hospital Universitário de Fortaleza, no período entre 2008 a 2011. Os dados foram coletados por formulário, organizados em tabelas e analisados por meio da estatística descritiva. Resultados: Houve média equilibrada em relação ao sexo e média de idade de 58,3 anos. O tempo de internação e diagnóstico da infecção foi de 21,2 e 11,7 dias, respectivamente. O cateter venoso central foi realizado em 89,3% dos pacientes. A topografia mais incidente foi a respiratória em 48,1%, e a Pseudomonas aeruginosa foi o principal patógeno encontrado em 18,3%. Os antimicrobianos mais utilizados foram os glicopeptídeos, representados pela Vancomicina e Teicoplanina. O desfecho clínico mais frequente foi o óbito em 65,4%. Conclusão: As IRAS no ambiente da terapia intensiva acometem um grande percentual de pacientes, sendo necessário a implementação de estratégias que visem reduzir as estatísticas e promover um ambiente hospitalar seguro. ================================================ Objective: to analyze Infections Related to Health Care (IRAS of patients in an Intensive Care Unit. Method: epidemiological retrospective study conducted at the University Hospital of Fortaleza, between 2008 and 2011. Data were collected, organized in tables, and analyzed using descriptive statistics. Results: equal number of female and male patients; average age of 58.3 years; average length of hospitalization and of diagnosis of infection of 21.2 and 11.7 days, respectively; central venous catheter performed in 89.3% of patients; most frequent topography: respiratory in 48.1% of patients; main identified pathogen: pseudomonas aeruginosa in 18.3% of patients; most used antimicrobials: glycopeptides, represented by vancomycin and teicoplanin; and, most frequent clinical

  1. 起病年龄对帕金森病运动并发症的影响%Relation between onset age and the motor complications involved in Parkinson' s disease

    Institute of Scientific and Technical Information of China (English)

    马敬红; 邹海强; 胡国华; 王枫; 孙菲; 陈彪

    2009-01-01

    目的 探讨起病年龄对帕金森病(PD)患者运动并发症的影响.方法 选取确诊为原发性PD且对左旋多巴制剂有效的195例患者进行随访,详细记录其发病年龄、运动并发症出现的时间等临床资料,并对所得资料进行统计学分析.结果 195例患者中57例早发和138例晚发患者平均起病后(3.88±3.33)年和(2.36±2.21)年开始服用左旋多巴制剂,两者相比较差异有统计学意义(t=3.142,P=0.002).早发和晚发患者由开始使用左旋多巴制剂到出现运动并发症的时间分别为(3.81±2.06)年和(4.24±2.00)年,两者相比较差异无统计学意义(t=-0.888,P=0.378).早发和晚发患者在开始用药时选择非左旋多巴制剂的比例分别为28.07%(16/57)和27.54%(38/138),两者相比较差异无统计学意义(χ2=0.006,P=0.940).早发和晚发患者在出现运动并发症时每天服用左旋多巴制剂的平均药量(mg)是601.8±296.7和655.6±192.5.两者相比较差异无统计学意义(t=-0.912,P=0.365).40岁以下发病的患者用药5年后运动并发症的发生率为7/10,71岁以上的患者为1/10.结论 早发患者推迟左旋多巴制剂的使用并不一定能延缓运动并发症的出现.早发患者易于出现运动并发症可能与其用药剂量和始用药物关系不大.发病年龄越早越易出现运动并发症,而70岁以后发病的患者出现运动并发症的危险性显著降低.%Objective To observe the relation between onset age and the motor complications involved Parkinaon' s disease (PD).Methods The detailed clinical information of 195 patients with idiopathic PD and good response to L-dopa were recorded and followed up.The data were calculated with SPSS statistic software.Results Although the time interval between the onset of the disease and the use of L-dopa was significantly longer in the 57 early-onset patients as compared to the 138 later-onset ones ((3.88±3.33) years vs (2.36±2.21) years, t = 3.142, P = 0.002), the time

  2. The visualization of DHSI based on the relationship model of CL and SA

    Science.gov (United States)

    Wang, Haibo; Guo, Huijuan; Xue, Chengqi

    2013-03-01

    The source and cause of cognitive load (CL) and situation awareness (SA) in digital human-system interface (DHSI) is explained. Based on the analysis of cognitive procedure and the relation of CL and SA, The relationship model of CL and SA in DHSI is put forward. Using the association target and the relationship model of CL and SA, the method and strategy of information visualization of DHSI is presented which is based on the cognitive psychology. Selecting the Boeing 757 autopilot as the case, the comparison of design is shown.

  3. Software reference for SaTool - a Tool for Structural Analysis of Automated Systems

    DEFF Research Database (Denmark)

    Lorentzen, Torsten; Blanke, Mogens

    2004-01-01

    This software reference details the functions of SaTool – a tool for structural analysis of technical systems. SaTool is intended used as part of an industrial systems design cycle. Structural analysis is a graph-based technique where principal relations between variables express the system...... of the graph. SaTool makes analysis of the structure graph to provide knowledge about fundamental properties of the system in normal and faulty conditions. Salient features of SaTool include rapid analysis of possibility to diagnose faults and ability to make autonomous recovery should faults occur....

  4. Redução de danos do uso indevido de drogas no contexto da escola promotora de saúde The drugs misuse related harm reduction in the health promoting schools

    Directory of Open Access Journals (Sweden)

    Fernanda Gonçalves Moreira

    2006-09-01

    Full Text Available Este trabalho tem por objetivo revisar os modelos de prevenção do uso indevido de drogas em ambiente escolar, relacionando-os aos conceitos de "promoção de saúde" e "escola promotora de saúde", e propor um modelo de intervenção. Os modelos de intervenção são múltiplos, os resultados provenientes das avaliações de impacto são modestos. As abordagens preventivas mais promissoras ampliam o campo de intervenções para o ambiente físico e social, enfocando a saúde como um todo, aproximando-se do conceito de promoção de saúde. A aplicação deste no âmbito escolar resultou no conceito de escola promotora de saúde. Esta pode ser definida como a escola com políticas, procedimentos, atividades e estrutura que resultem na proteção e promoção à saúde e ao bem-estar de todos os membros da comunidade escolar. A proposta da "redução de danos", pensada como estratégia de prevenção, converge para a da escola promotora de saúde, e neste sentido propomos ações de promoção de saúde pautadas por: objetivos amplos e escalonados; ruptura com o maniqueísmo; ações inclusivas; parcerias intersetoriais; incentivo à autonomia dos alunos; abordagem do indivíduo em toda a sua complexidade. Esta proposta amplia a abrangência da intervenção para todos os alunos, independentemente se estes já experimentaram, já fizeram ou fazem algum uso de substâncias psicoativas.The goal of this paper is to review the school-based drugs misuse prevention programs, and to establish a connection with the "health promotion" and "health promoting school" concepts, in an attempt to create a new proposal. There are several models of preventive intervention, but the results of its evaluations show little improvement. The most hopeful programs imply in giving up the restrict focus of prevention (of a specific disease to adopt the health promotion concept. The application of the health promotion concept in the school environment resulted in the

  5. Adult onset tic disorders

    OpenAIRE

    Chouinard, S; Ford, B.

    2000-01-01

    BACKGROUND—Tic disorders presenting during adulthood have infrequently been described in the medical literature. Most reports depict adult onset secondary tic disorders caused by trauma, encephalitis, and other acquired conditions. Only rare reports describe idiopathic adult onset tic disorders, and most of these cases represent recurrent childhood tic disorders.
OBJECTIVE—To describe a large series of patients with tic disorders presenting during adulthood, to compare cl...

  6. Saúde, minorias e desigualdade: algumas teias de inter-relações, com ênfase nos povos indígenas no Brasil Health, minorities and inequality: some webs of inter-relations, emphasizing indigenous peoples in Brazil

    Directory of Open Access Journals (Sweden)

    Carlos Everaldo Alvares Coimbra Jr.

    2000-01-01

    Full Text Available No Brasil, não há uma produção sistemática acerca do peso da dimensão étnico-racial na expressão diferenciada dos agravos à saúde. No cotidiano, minorias vivenciam situações de exclusão, marginalidade e discriminação que as colocam em posição de maior vulnerabilidade frente a agravos à saúde. Neste texto é enfocada, em particular, a situação dos povos indígenas. Coeficientes de morbi-mortalidade mais altos do que os registrados em nível nacional, fome e desnutrição, riscos ocupacionais e violência social são apenas alguns dos múltiplos reflexos sobre a saúde decorrentes da persistência de desigualdades. É importante que sejam realizados esforços no sentido de reverter uma preocupante invisibilidade demográfica e epidemiológica resultante da ausência de informações confiáveis para as populações indígenas nas bases de dados oficiais. Isso possibilitará compreender melhor a gênese, determinantes e formas de reprodução das desigualdades em saúde no Brasil. Tais conhecimentos são fundamentais para o embasamento tanto de atuações políticas, inclusive por parte de lideranças indígenas, como de intervenções com vistas à promoção da eqüidade em saúde.In Brazil, few studies have analyzed the impacts of the ethnic-racial dimension upon the expression of health issues. In their daily lives, minorities experience situations of exclusion, marginality and discrimination that make them particularly vulnerable to health problems. In this paper we primarily focus on indigenous peoples. Rates of morbidity and mortality above national levels, hunger, undernutrition, occupational hazards and social violence are some of the multiple health-disease outcomes that derive from the persistence of inequalities. It is important that conditions are created in order to revert the current situation of demographic and epidemiological "invisibility" faced by indigenous peoples in Brazil, which in part stem from the

  7. To treat or not to treat with testosterone replacement therapy: a contemporary review of management of late-onset hypogonadism and critical issues related to prostate cancer.

    Science.gov (United States)

    Kava, Bruce R

    2014-07-01

    Over the last 10 years there has been a dramatic increase in the number of patients identified and treated with testosterone replacement therapy (TRT) for late-onset hypogonadism (LOH). By virtue of age, race, and family history, many of these patients are concurrently at risk for harboring indolent prostate cancer. Other men are at increased risk for prostate cancer as a result of an elevated serum PSA level or having had a prior prostate biopsy showing prostatic intraepithelial neoplasia (PIN) or atypical small acinar proliferation (ASAP). The clinician is often challenged with the decision whether to initiate TRT in these patients. This review presents a contemporary overview of the rationale for TRT, as well as the relationship between testosterone (endogenous and exogenous) and premalignant and malignant lesions of the prostate. We will discuss preliminary data from several recent series demonstrating that TRT may be safely administered in select patients with certain premalignant and bona fide malignant tumors of the prostate. In the absence of a large randomized clinical trial with long-term outcome data evaluating TRT, we hope that this overview will provide clinicians with an evidence-based approach to managing these anxiety-provoking - and often frustrating - clinical scenarios.

  8. Traffic-related air pollution and the onset of myocardial infarction: disclosing benzene as a trigger? A small-area case-crossover study.

    Directory of Open Access Journals (Sweden)

    Denis Bard

    Full Text Available Exposure to traffic is an established risk factor for the triggering of myocardial infarction (MI. Particulate matter, mainly emitted by diesel vehicles, appears to be the most important stressor. However, the possible influence of benzene from gasoline-fueled cars has not been explored so far.We conducted a case-crossover study from 2,134 MI cases recorded by the local Coronary Heart Disease Registry (2000-2007 in the Strasbourg Metropolitan Area (France. Available individual data were age, gender, previous history of ischemic heart disease and address of residence at the time of the event. Nitrogen dioxide, particles of median aerodynamic diameter <10 µm (PM10, ozone, carbon monoxide and benzene air concentrations were modeled on an hourly basis at the census block level over the study period using the deterministic ADMS-Urban air dispersion model. Model input data were emissions inventories, background pollution measurements, and meteorological data. We have found a positive, statistically significant association between concentrations of benzene and the onset of MI: per cent increase in risk for a 1 µg/m3 increase in benzene concentration in the previous 0, 0-1 and 1 day was 10.4 (95% confidence interval 3-18.2, 10.7 (2.7-19.2 and 7.2 (0.3-14.5, respectively. The associations between the other pollutants and outcome were much lower and in accordance with the literature.We have observed that benzene in ambient air is strongly associated with the triggering of MI. This novel finding needs confirmation. If so, this would mean that not only diesel vehicles, the main particulate matter emitters, but also gasoline-fueled cars--main benzene emitters-, should be taken into account for public health action.

  9. Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer's disease.

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    Qiongshi Lu

    2017-07-01

    Full Text Available Continuing efforts from large international consortia have made genome-wide epigenomic and transcriptomic annotation data publicly available for a variety of cell and tissue types. However, synthesis of these datasets into effective summary metrics to characterize the functional non-coding genome remains a challenge. Here, we present GenoSkyline-Plus, an extension of our previous work through integration of an expanded set of epigenomic and transcriptomic annotations to produce high-resolution, single tissue annotations. After validating our annotations with a catalog of tissue-specific non-coding elements previously identified in the literature, we apply our method using data from 127 different cell and tissue types to present an atlas of heritability enrichment across 45 different GWAS traits. We show that broader organ system categories (e.g. immune system increase statistical power in identifying biologically relevant tissue types for complex diseases while annotations of individual cell types (e.g. monocytes or B-cells provide deeper insights into disease etiology. Additionally, we use our GenoSkyline-Plus annotations in an in-depth case study of late-onset Alzheimer's disease (LOAD. Our analyses suggest a strong connection between LOAD heritability and genetic variants contained in regions of the genome functional in monocytes. Furthermore, we show that LOAD shares a similar localization of SNPs to monocyte-functional regions with Parkinson's disease. Overall, we demonstrate that integrated genome annotations at the single tissue level provide a valuable tool for understanding the etiology of complex human diseases. Our GenoSkyline-Plus annotations are freely available at http://genocanyon.med.yale.edu/GenoSkyline.

  10. Dioecious plants are more precocious than cosexual plants: A comparative study of relative sizes at the onset of sexual reproduction in woody species.

    Science.gov (United States)

    Ohya, Itsuki; Nanami, Satoshi; Itoh, Akira

    2017-08-01

    The reproductive capacities of dioecious plant species may be limited by severe pollen limitation and narrow seed shadows for the two reasons. First, they are unable to self-pollinate, and seed production occurs only with pollinator movement from males to females. Second, only 50% of the individuals in populations contribute to seed production. Despite these handicaps, dioecious plants maintain their populations in plant communities with cooccurring cosexual plants, and no substantial difference in population growth rates has been found between dioecious and cosexual plants. Hence, dioecious plants are thought to mitigate these disadvantages by adopting ecological traits, such as insect pollination, animal-dispersed fleshy fruits, and precocious flowering. We studied the relationship between flowering and plant size in 30 woody species with different sex expressions, leaf habits, fruit types, and maximum plant sizes. The study site was located in an evergreen broad-leaved forest on the island of Honshu, Japan. A phylogenetic linear regression model showed that dioecious species tended to mature at smaller sizes than did cosexual taxa. At the population level, given equal plant densities and reproductive efforts, the precocity of dioecious plants could serve as one of the factors that mitigate the limitations of pollen and seed-shadow handicaps by increasing the density of reproductive individuals in the population. At the individual level, smaller size of onset of flowering may play a role in enhancing reproductive success over a lifetime by increasing reproductive opportunities. We discussed the possible effect of the relationship between precocity and some ecological traits of dioecious plants, such as small flowers pollinated by unspecialized insects, fleshy fruit dispersed by animals, and their preferential occurrence in the tropics and in island habitats. The universality of precocity among dioecious plants should be investigated in diverse plant communities

  11. Menarche, oral contraceptives, pregnancy and progression of disability in relapsing onset and progressive onset multiple sclerosis

    NARCIS (Netherlands)

    D'hooghe, M. B.; Haentjens, P.; Nagels, G.; D'Hooghe, T.; De Keyser, J.

    2012-01-01

    Female gender and hormones have been associated with disease activity in multiple sclerosis (MS). We investigated age at menarche, use of oral contraceptives and pregnancy in relation to progression of disability in relapsing onset and progressive onset MS. We conducted a cross-sectional survey amon

  12. [Sudden onset diplopia].

    Science.gov (United States)

    Besch, D; Schuettauf, F

    2013-09-01

    Sudden onset diplopia may occur secondary to something as simple as uncorrected refractive error or as complicated as brainstem disorders in conjunction with other symptoms. Therefore, all complaints of diplopia must be a cause for concern. Ophthalmologists have to determine if diplopia is the first sign of a systemic or neurological disorder, which needs to be referred to a specialist or can be managed by the practitioner. In this paper the importance of the case history, primary diagnostic options, the indications for supplementary testing with computed tomography (CT) or magnetic resonance imaging (MRI) as well as treatment options when a patient complains of sudden onset diplopia are discussed.

  13. Onset of magnetospheric substorms.

    Science.gov (United States)

    Tsurutani, B.; Bogott, F.

    1972-01-01

    An examination of the onset of magnetospheric substorms is made by using ATS 5 energetic particles, conjugate balloon X rays and electric fields, all-sky camera photographs, and auroral-zone magnetograms. It is shown that plasma injection to ATS distances, conjugate 1- to 10-keV auroral particle precipitation, energetic electron precipitation, and enhancements of westward magnetospheric electric-field component all occur with the star of slowly developing negative magnetic bays. No trapped or precipitating energetic-particle features are seen at ATS 5 when later sharp negative magnetic-bay onsets occur at Churchill or Great Whale River.

  14. Androgen replacement therapy improves psychological distress and health-related quality of life in late onset hypogonadism patients in Chinese population

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-wei; LIU Zhen-hua; HU Xiao-wei; YUAN Ye-qing; BAI Wen-jun; WANG Xiao-feng; SHEN Huan; ZHAO Yong-ping

    2012-01-01

    Background Late onset hypogonadism negatively impacts on men's psychological well-being.This study was conducted to examine the interrelationship among symptoms of testosterone deficiency,psychological well-being,and quality of life.Methods Eligible subjects were randomized into active treatment and control groups,and were asked to complete the following questionnaires at baseline and month 6:aging male's symptoms (AMS) rating scale,hospital anxiety and depression scale (HADS),perceived stress scale (PSS) and the short form health survey-12 (SF-12).In this study,men were treated and monitored for 6 months with oral testosterone undecanoate (TU) capsules or vitamin E/C capsules in a single-blinded fashion.All in the active treatment group were administered a total of 120-160 mg TU orally on a daily basis.Total and free T levels between baseline and month 6 were compared.Results One hundred and sixty eligible subjects were recruited and followed up.In the active treatment group,total serum testosterone concentrations before and after intervention were (7.98±0.73) nmol/L and (13.7±1.18) nmol/L.The mean HADS anxiety subscale scores for the subjects at baseline and at month 6 were 3.47±0.4 and 1.72±0.2,respectively (t=1.526,P<0.05).Additionally,the mean HADS depression subscale scores were 4.91±0.6 and 2.39±0.3,respectively (t=3.466,P<0.05).The mean scores on PSS for the subjects at baseline and at month 6 were 12.88±2.1 and 9.83±1.7,respectively (t=4.009,P<0.05).Significantly improved SF-12 could be observed (t=1.433 and 1.118,respectively; both P<0.05).No significant changes were observed in the control group at month 6.Conclusion Androgen replacement not only improves androgen deficiency associated symptoms,but also enhances comprehensive improvement in psychological issues.(No.ChiCTR-TRC-11001811)

  15. Prevalência da abstinência ao tabaco de pacientes tratados em unidades de saúde e fatores relacionados The prevalence of abstinence from tobacco in patients treated in health units and related factors

    Directory of Open Access Journals (Sweden)

    Alexandre Coutinho Sattler

    2013-01-01

    Full Text Available O objetivo é conhecer a prevalência e identificar as variáveis relacionadas com a abstinência do tabaco em pacientes tratados nos Grupos de Apoio Terapêutico ao Tabagista (GATT em unidades de saúde do município de Vitória (ES, no ano de 2009. Estudo transversal com 160 participantes do GATT que participaram de 75% das sessões. Realizada entrevista por telefone, 9 a 20 meses após o tratamento, e usado dados secundários do roteiro de entrevista inicial. Na análise estatística, foram utilizados os testes qui-quadrado e Fisher. A significância estatística foi 5%. Eram abstinentes 28,7%, recaíram 51,9% e 19,4% não pararam de fumar. Houve diferença estatística entre os grupos nas variáveis estado civil (0,039, tentativas anteriores para parar de fumar (0,029, quantidade de cigarros fumados por dia (0,019, uso de fármacos (0,001 e transtorno do humor referidos (0,040. O grupo de abstinente teve mais casados, tentou mais vezes parar de fumar, fumou menos cigarro/dia, apresentou menos ansiedade/alteração do humor. A abstinência foi semelhante a outros estudos e o maior percentual de sujeitos recaiu.The scope of this study is to discover the prevalence and identify the variables related to tobacco abstinence in patients treated for quitting smoking through group therapy or support groups in primary health care units of the municipality of Vitória, State of Espirito Santo, in the year of 2009. A cross-sectional study was performed with 160 participants of the support groups who participated in 75% of the sessions. Telephone interviews were conducted 9 to 20 months after treatment and secondary data from the text of the initial interview were used. Chi-square and Fischer tests were used in statistical analysis and the statistical significance was 5%. It was found that 28.7% were abstainers, 51.9% had relapsed and 19.4% never stopped smoking. There was a statistical difference between the groups in the variables of marital status (0

  16. Aptidão física relacionada à saúde em escolares de Jequié, BA, Brasil Health-related physical fitness in students from Jequié, BA, Brazil

    Directory of Open Access Journals (Sweden)

    Valfredo Dórea

    2008-12-01

    Full Text Available O objetivo deste estudo foi analisar a aptidão física relacionada à saúde (AFRS em escolares de Jequié, BA, Brasil. Para tanto, a AFRS de 182 meninos e 160 meninas (sete a 12 anos, escolares da rede pública de ensino, foi avaliada mediante a aplicação dos testes motores corrida/caminhada de nove minutos (indicador de resistência cardiorrespiratória, abdominal modificado em um minuto (indicador de força e resistência abdominal, sentar-e-alcançar (indicador de flexibilidade. O somatório das espessuras das dobras cutâneas tricipital e subescapular foi utilizado como indicador de gordura corporal. Os resultados encontrados indicaram maior prevalência de meninos e meninas abaixo (19% e 49%, respectivamente do que acima (3% e 1%, respectivamente dos critérios estabelecidos pela AAHPERD (1988 para indicadores de gordura corporal. Por outro lado, somente 51% dos meninos e 58% das meninas no sentar-e-alcançar; 11% e 7%, respectivamente, no abdominal modificado em um minuto, e 15% e 14%, respectivamente, na corrida/caminhada de nove minutos alcançaram os critérios estabelecidos. Portanto, os resultados sugerem que programas efetivos de intervenção parecem necessários para a promoção de mudanças no estado nutricional e na atividade física habitual de escolares de Jequié.The aim of this study was to analyze the health-related physical fitness (HRPF in students from Jequié, BA, Brazil. Therefore, the HRPF of 182 boys and 160 girls aged 7-12 years, students from public schools, was assessed by the application of 9-minute-run/walk (indicator of cardiorespiratory capacity, modified in one minute abdominal (indicator of abdominal strength and endurance, sit-and-reach (indicator of flexibility motor tests. The sum of the triciptal and subscapular skinfolds thickness was used as indicator of body fat. The results found indicated higher prevalence of boys and girls below (19% and 49%, respectively than above (3% and 1%, respectively the

  17. Auditory change detection in schizophrenia: sources of activity, related neuropsychological function and symptoms in patients with a first episode in adolescence, and patients 14 years after an adolescent illness-onset

    Directory of Open Access Journals (Sweden)

    Sachsse Jan

    2006-02-01

    Full Text Available Abstract Background The event-related brain response mismatch negativity (MMN registers changes in auditory stimulation with temporal lobe sources reflecting short-term echoic memory and frontal sources a deviance-induced switch in processing. Impairment, controversially present at the onset of schizophrenia, develops rapidly and can remain independent of clinical improvement. We examined the characteristics of the scalp-recorded MMN and related these to tests of short-term memory and set-shifting. We assessed whether the equivalent dipole sources are affected already at illness-onset in adolescence and how these features differ after a 14-year course following an adolescent onset. The strength, latency, orientation and location of frontal and temporal lobe sources of MMN activity early and late in the course of adolescent-onset schizophrenia are analysed and illustrated. Methods MMN, a measure of auditory change-detection, was elicited by short deviant tones in a 3-tone oddball-presentation and recorded from 32 scalp electrodes. Four dipole sources were placed following hypothesis-led calculations using brain electrical source analysis on brain atlas and MR-images. A short neuropsychological test battery was administered. We compared 28 adolescent patients with a first episode of schizophrenia and 18 patients 14 years after diagnosis in adolescence with two age-matched control groups from the community (n = 22 and 18, respectively. Results MMN peaked earlier in the younger than the older subjects. The amplitude was reduced in patients, especially the younger group, and was here associated with negative symptoms and slow set-shifting. In first-episode patients the temporal lobe sources were more ventral than in controls, while the left cingular and right inferior-mid frontal sources were more caudal. In the older patients the left temporal locus remained ventral (developmental stasis, the right temporal locus extended more antero

  18. A gerência nos serviços públicos de saúde: um relato de experiência Manager in health public services: relate for an experience

    Directory of Open Access Journals (Sweden)

    Lislaine Aparecida de Fraccolli

    2000-06-01

    Full Text Available Este estudo tem como objetivo discutir as tecnologias em uso na gestão dos serviços públicos de saúde. Os dados empíricos sobre os quais essa análise se esboça partem da vivência profissional de um dos autores como assessor técnico junto à Secretaria Estadual de Saúde de São Paulo. A prática de gerência vivenciada é confrontada com as propostas de tecnologia gerencial trazidas por MERHY; ONOCKO (1997 e articulada às estratégias de construção de sujeitos plenos a partir do trabalho. As conclusões indicam a necessidade de se repensar as tecnologias gerenciais em uso e apontam novos instrumentos gerenciais.This study has as objective to discuss technologies in use in administration of public health's services. The empiric data which this analysis it sketches are based in a professional experience of one of the authors as technical adviser close to Government Bureau of Health of São Paulo. The practice of management experienced is confronted with proposals of managerial technology brought by MERHY; ONOCKO (1997 and articulated to strategies of construction of full subjects starting from the work. The conclusions indicate the need to rethink the managerial technologies in use and they aim new managerial instruments.

  19. SA1 binds directly to DNA through its unique AT-hook to promote sister chromatid cohesion at telomeres.

    Science.gov (United States)

    Bisht, Kamlesh K; Daniloski, Zharko; Smith, Susan

    2013-08-01

    Sister chromatid cohesion relies on cohesin, a complex comprising a tri-partite ring and a peripheral subunit Scc3, which is found as two related isoforms SA1 and SA2 in vertebrates. There is a division of labor between the vertebrate cohesin complexes; SA1-cohesin is required at telomeres and SA2-cohesin at centromeres. Depletion of SA1 has dramatic consequences for telomere function and genome integrity, but the mechanism by which SA1-cohesin mediates cohesion at telomeres is not well understood. Here we dissect the individual contribution of SA1 and the ring subunits to telomere cohesion and show that telomeres rely heavily on SA1 and to a lesser extent on the ring for cohesion. Using chromatin immunoprecipitation we show that SA1 is highly enriched at telomeres, is decreased at mitosis when cohesion is resolved, and is increased when cohesion persists. Overexpression of SA1 alone was sufficient to induce cohesion at telomeres, independent of the cohesin ring and dependent on its unique (not found in SA2) N-terminal domain, which we show binds to telomeric DNA through an AT-hook motif. We suggest that a specialized cohesion mechanism may be required to accommodate the high level of DNA replication-associated repair at telomeres.

  20. "Você aprende. A gente ensina?": interrogando relações entre educação e saúde desde a perspectiva da vulnerabilidade "You learn, we teach"?: questioning relations between education and health from the perspective of vulnerability

    Directory of Open Access Journals (Sweden)

    Dagmar E. Estermann Meyer

    2006-06-01

    Full Text Available Neste artigo, a exploração dos sentidos associados à frase-síntese de uma campanha promovida no Dia Mundial Sem Tabaco instiga a discussão das principais ênfases constitutivas do campo da educação em saúde, no Brasil. Retoma-se o conceito de vulnerabilidade para situar/explorar suas interseções com o educativo para, então, apontar a produtividade teórico-prática e política da articulação entre educação em saúde e estudos de vulnerabilidade. Conclui-se que a necessária renovação das práticas de saúde em geral e, particularmente, das práticas de educação em saúde, pode beneficiar-se grandemente do referencial da vulnerabilidade, na medida em que ele delineia um novo horizonte para situar e articular riscos, "causalidades" e "determinações", trazendo a saúde ­ assim como a possibilidade de adoecer ­ para o campo da vida real, para o mundo dos sujeitos em relação, no qual esses processos ganham sentidos singulares.This article explores the meanings associated with the motto used in a World No-Tobacco Day campaign to stimulate a discussion of the principal underlying messages in the field of health education in Brazil. The study focuses on the concept of vulnerability to contextualize and explore its interfaces with education in order to highlight the theoretical, practical, and political productivity of the link between health education and studies on vulnerability. In conclusion, the necessary renewal of health practices in general and health education practices in particular can benefit tremendously from the vulnerability reference, to the extent that it demarcates a new horizon for situating and linking risks, "causalities", and "determinations", drawing health ­ as well as the possibility of illness ­ into the field of real life, into the world of inter-subjective relations, where these processes gain unique meanings.

  1. [Differences between species involved and fluoroquinolone resistance patterns of strains isolated from bacteriuria according to nosocomial, health-related or community-acquired onset].

    Science.gov (United States)

    Tassain, Jérome; N'Guyen, Yohan; Batalla, Anne-Sophie; Duval, Véronique; Guillard, Thomas; De Champs, Christophe; Strady, Christophe

    2012-12-01

    To describe and to compare species and antibiotics resistance patterns of bacteria involved among bacteriuria from hospital and city laboratories and among health-related and community-acquired bacteriuria. Epidemiologic transversal study conducted among Bacteriology laboratories of University Hospital (UH) and the whole city of Reims, during the week 21 to 26 June 2010. A standardized investigation form was completed after telephonical interview with the prescriber. One hundred and eighty-nine strains have been isolated among 179 urocultures. One hundred and seven strains were isolated in city laboratories and 82 in UH laboratory. Strains were community-acquired, health-related and nosocomial in 136, 22 and 31 cases, respectively. More Gram positive bacteria and ofloxacin resistant strains were isolated among UH strains (P=0.001 and P=0.015, respectively) and among health-related strains (P=0.01 and P=0.003, respectively). When analysis was restricted only to Enterobacteriaceae or to Escherichia coli, the ofloxacin resistance rate was no more elevated among health-related or UH strains. Ofloxacin resistant Enterobacteriaceae were more frequently resistant to all other classes of antibiotics except nitrofurans. Strains isolated in health-related bacteriuria are more frequently ofloxacin resistant principally because of the greater proportion of Gram positive bacteria and because of a non-significant higher ofloxacin resistance rate among Enterobacteriaceae. Numerous studies only focus on Enterobacteriaceae, and the data from our study need to be confirmed on larger samples, in order to validate the predictive value of health-related bacteriuria for ofloxacin resistance. Copyright © 2012. Published by Elsevier Masson SAS.

  2. Health-related quality of life determinants in outpatients with heart failure Determinantes de la calidad de vida relacionada a la salud en pacientes atendidos en ambulatorios con insuficiencia cardíaca Determinantes da qualidade de vida relacionada à saúde em pacientes ambulatoriais com insuficiência cardíaca

    Directory of Open Access Journals (Sweden)

    Viviane Martinelli Pelegrino

    2011-06-01

    Full Text Available This descriptive and exploratory study analyzed variables associated with health-related quality of life among 130 outpatients. Health-related quality of life was measured through the Minnesota Living with Heart Failure Questionnaire. Significant associations were found between patients’ health-related quality of life and their age (r=-0.177; p=0.044, vitality (r=-0.625; p=Trata-se de estudo descritivo e exploratório que analisou as variáveis associadas à qualidade de vida relacionada à saúde (QVRS, de 130 pacientes com insuficiência cardíaca, em seguimento ambulatorial. A QVRS foi avaliada pelo Minnesota Living with Heart Failure e realizada análise de regressão linear. A média da QVRS foi de 34,9 (dp=24,8; intervalo de 0 a 99. Foram encontradas associações significantes entre a medida da QVRS e idade (r=-0,177; p=0,044, vitalidade (r=-0,625; p=<0,001 e saúde mental (r=-0,672; p=<0,001, domínios do SF-36. A regressão linear mostrou que a gravidade dos sintomas da insuficiência cardíaca, e dois domínios do SF-36, vitalidade e saúde mental, explicaram 54% da variação da medida da QVRS. Controlar os sintomas e manter bem-estar mental é essencial para a manutenção da QVRS e são essenciais para o cuidado eficaz da insuficiência cardíaca.

  3. Effect of soothing-liver and nourishing-heart acupuncture on early selective serotonin reuptake inhibitor treatment onset for depressive disorder and related indicators of neuroimmunology: a randomized controlled clinical trial.

    Science.gov (United States)

    Liu, Yi; Feng, Hui; Mo, Yali; Gao, Jingfang; Mao, Hongjing; Song, Mingfen; Wang, Shengdong; Yin, Yan; Liu, Wenjuan

    2015-10-01

    To observe the effect of soothing-liver and nourishing-heart acupuncture on selective serotonin reuptake inhibitor (SSRIs) treatment effect onset in patients with depressive disorder and related indicators of neuroimmunology. Overall, 126 patients with depressive disorder were randomly divided into a medicine and acupuncture-medicine group using a random number table. Patients were treated for 6 consecutive weeks. The two groups were evaluated by the Montgomery-Asberg Depression Rating Scale (MADRS) and Side Effects Rating Scale (SERS) to assess the effect of the soothing-liver and nourishing-heart acupuncture method on early onset of SSRI treatment effect. Changes in serum 5-hydroxytryptamine (5-HT) and inflammatory cytokines before and after treatment were recorded and compared between the medicine group and the acupuncture-medicine group. The acupuncture-medicine group had significantly lower MADRS scores at weeks 1, 2, 4, and 6 after treatment compared with the medicine group (P treatment compared with the medicine group (P treatment, serum 5-HT in the acupuncture-medicine group was significantly higher compared with the medicine group (P 0.05). Anti-inflammatory cytokines IL-4 and IL-10 were significantly higher in the acupuncture-medicine group compared with the medicine group (P depressive disorder and can significantly reduce the adverse reactions of SSRIs. Moreover, acupuncture can enhance serum 5-HT and regulate the balance of pro-inflammatory cytokines and anti-inflammatory cytokines.

  4. Conceptual and methodological aspects of relations between discrimination and health in epidemiological studies Aspectos conceituais e metodológicos das relações entre discriminação e saúde em estudos epidemiológicos

    Directory of Open Access Journals (Sweden)

    João Luiz Bastos

    2012-01-01

    Full Text Available This article addresses conceptual and methodological aspects of the relations between discrimination and health from an epidemiological perspective. Definitions of discrimination and related constructs are reviewed, and the main theories underlying their association with health are presented. Scales developed to assess discrimination are discussed, in conjunction with a new instrument, devised to operationalize the concept in Brazilian epidemiological surveys. As a relatively unpredictable and uncontrollable source of psychosocial stress, discrimination has been consistently associated with adverse health outcomes and behaviors, particularly mental disorders, smoking, and alcohol use. However, progress in the area depends partly on dealing with aspects related to the assessment of the phenomenon, such as the definition of a construct map and simultaneous measurement of different types of discrimination. Research involving these aspects will enhance our understanding of discrimination and its health consequences, thus increasing our ability to reduce its social occurrence.Abordam-se aspectos conceituais e metodológicos das relações entre discriminação e saúde, sob uma perspectiva epidemiológica. São revisadas definições de discriminação, construtos correlatos e apresentadas as teorias subjacentes à interpretação de suas associações com saúde. Discutem-se os instrumentos desenvolvidos para aferição da discriminação e uma proposta para sua operacionalização em inquéritos epidemiológicos brasileiros. Enquanto fonte de estresse psicossocial relativamente imprevisível e de difícil controle, a discriminação tem sido consistentemente associada com piores condições/comportamentos em saúde, sobretudo transtornos mentais, tabagismo e uso de álcool. Entretanto, avanços na área dependem, em parte, do enfrentamento de questões vinculadas à aferição do fenômeno, como a definição de um mapa do construto e a necessidade

  5. Late-Onset Asthma

    DEFF Research Database (Denmark)

    Ulrik, Charlotte Suppli

    2017-01-01

    Late-onset asthma is common, associated with poor outcome, underdiagnosed and undertreated, possibly due to the modifying effect of ageing on disease expression. Although the diagnostic work-up in elderly individuals suspected of having asthma follows the same steps as in younger individuals (case......, to objectively confirm asthma. If necessary, a trial of oral or inhaled corticosteroid might be necessary. Asthma can be diagnosed when increased airflow variability is identified in a symptomatic patient, and if the patient does not have a history of exposure, primarily smoking, known to cause chronic...... obstructive pulmonary disease, the diagnosis is asthma even if the patient does not have fully reversible airflow obstruction. Pharmacological therapy in patients with late-onset asthma follows international guidelines, including treatment with the lowest effective dose of inhaled corticosteroid to minimize...

  6. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits.

    Science.gov (United States)

    Joseph, J A; Shukitt-Hale, B; Denisova, N A; Prior, R L; Cao, G; Martin, A; Taglialatela, G; Bickford, P C

    1998-10-01

    Recent research has indicated that increased vulnerability to oxidative stress may be the major factor involved in CNS functional declines in aging and age-related neurodegenerative diseases, and that antioxidants, e.g., vitamin E, may ameliorate or prevent these declines. Present studies examined whether long-term feeding of Fischer 344 rats, beginning when the rats were 6 months of age and continuing for 8 months, with diets supplemented with a fruit or vegetable extract identified as being high in antioxidant activity, could prevent the age-related induction of receptor-mediated signal transduction deficits that might have a behavioral component. Thus, the following parameters were examined: (1) oxotremorine-enhanced striatal dopamine release (OX-K+-ERDA), (2) cerebellar beta receptor augmentation of GABA responding, (3) striatal synaptosomal 45Ca2+ clearance, (4) carbachol-stimulated GTPase activity, and (5) Morris water maze performance. The rats were given control diets or those supplemented with strawberry extracts (SE), 9.5 gm/kg dried aqueous extract (DAE), spinach (SPN 6.4 gm/kg DAE), or vitamin E (500 IU/kg). Results indicated that SPN-fed rats demonstrated the greatest retardation of age-effects on all parameters except GTPase activity, on which SE had the greatest effect, whereas SE and vitamin E showed significant but equal protection against these age-induced deficits on the other parameters. For example, OX-K+-ERDA enhancement was four times greater in the SPN group than in controls. Thus, phytochemicals present in antioxidant-rich foods such as spinach may be beneficial in retarding functional age-related CNS and cognitive behavioral deficits and, perhaps, may have some benefit in neurodegenerative disease.

  7. Relações entre padrão do sono, saúde percebida e variáveis socioeconômicas em uma amostra de idosos residentes na comunidade: Estudo PENSA Relations between sleep patterns, perceived health and socioeconomic variables in a sample of community resident elders: PENSA Study

    Directory of Open Access Journals (Sweden)

    Beatriz Helena Domingos Oliveira

    2010-05-01

    Full Text Available O padrão de sono se destaca por estar entre as mais frequentes queixas dos idosos. Mudanças na velhice podem ser observadas em diversos níveis da arquitetura e qualidade do sono. Assim, o objetivo do presente estudo foi observar a relação entre alterações do sono associadas à idade, sintomas de insônia, sintomas de apnéia e sintomas de parassonia com variáveis socioeconômicas e saúde autopercebida. O padrão de sono foi avaliado pelo Mini-Sleep Questionary. Os resultados apontaram que as mulheres e o grupo com menor escolaridade apresentaram maior frequência de sintomas de insônia, os idosos-idosos e o grupo com melhor percepção da saúde apresentaram menor frequência de sintomas apnéicos, e melhor percepção da saúde geral associou-se a melhor padrão de sono. Conclui-se que o padrão do sono é influenciado por características socioeconômicas como idade, gênero, escolaridade e saúde geral percebida.Changes in sleep pattern constitute a common complaint among elders. Age-related changes can be observed in different levels of the architecture and quality of sleep. The objective of the present study was to observe the relation between age-related sleep changes, insomnia symptoms, apnea symptoms, parasomnia symptoms with socio-economic variables and perceived health status. Sleep pattern was evaluated using the Mini-Sleep Questionnaire. Results indicated that women and individuals with lower education reported higher frequency of insomnia symptoms, the elder-elder group. On the other hand, individuals with higher perceived health status presented lower frequency of apnea symptoms, and higher perceived health status was associated to better sleep pattern overall. It can be concluded that sleep pattern is associated to socio-economic variables such as age, gender, education and perceived health.

  8. A enfermagem de saúde pública no Distrito Federal: a influência do relatório Goldmark (1923 A 1927 La enfermería de salud publica en el Distrito Federal: la influencia del relato goldmark (1923 hasta 1927 The public health nursing in the Distrito Federal: the influence of the goldmark report (1923 to 1927

    Directory of Open Access Journals (Sweden)

    Mary Ann Menezes Freire

    2008-03-01

    Full Text Available Estudo histórico-social, embasado na análise documental. Investiga as influências do Relatório Goldmark na organização da enfermagem de saúde pública, após o processo da Reforma Carlos Chagas, de 1923 a 1927. Objetivos: identificar as circunstâncias em que se deram as primeiras propostas para organizar a enfermagem de saúde pública durante a Reforma Carlos Chagas; analisar as implicações do Relatório Goldmark para a organização do saber e do fazer na enfermagem de saúde pública, na Capital da República, na década de 1920. Podemos citar como uma das implicações do Relatório Goldmark na organização da enfermagem de saúde pública no Distrito Federal a alteração do Standard Curriculum, adotado pela Escola de Enfermagem do Departamento Nacional de Saúde Pública, diante de uma de suas questões centrais, que procurou produzir um equilíbrio no ensino teórico-prático, o que provocou reflexos no saber e no fazer das enfermeiras de saúde pública.Estudio histórico-social basado en el análisis documental. Investiga las influencias del Relato Goldmark en la enfermería de salud publica después del proceso de la Reforma Carlos Chagas, 1923 - 1927. Objetivos: Identificar las condiciones en que ocurrieron las primeras propuestas para organizar la enfermería de salud publica en la Reforma Carlos Chagas; Analizar las implicaciones del Relato Goldmark para la organización de lo saber y de lo hacer en la enfermería de salud publica en la Capital de la Republica en la década de 1920. Podemos citar cómo una de las implicaciones del Relato Goldmark en la organización de la enfermería de salud publica en el Distrito Federal la alteración del "Standart Curriculum", adoptado por la Escuela de Enfermería del Departamento Nacional de Salud Publica, frente una de sus cuestiones centrales que intent�� producir un equilibrio en la enseñanza teórica y practica, lo que causó reflejo en lo saber y el que hacer de las

  9. Saúde e meio ambiente nas cidades: os desafios da saúde ambiental

    Directory of Open Access Journals (Sweden)

    Nelson Gouveia

    1999-02-01

    Full Text Available Dentro de alguns poucos anos, nosso planeta contará com mais habitantes em áreas urbanas do que em áreas rurais. A urbanização desenfreada, sem mecanismos regulatórios e de controle, típica dos países periféricos, trouxe consigo enormes repercussões na saúde da população. Problemas como a insuficiência dos serviços básicos de saneamento, coleta e destinação adequada do lixo e condições precárias de moradia, tradicionalmente relacionados com a pobreza e o subdesenvolvimento, somam-se agora à poluição química e física do ar, da água e da terra, problemas ambientais antes considerados "modernos". Novamente, é sobre as populações mais carentes que recai a maior parte dos efeitos negativos da urbanização, gerando uma situação de extrema desigualdade e iniqüidade ambiental e em saúde. Para reverter esse quadro é preciso que haja uma reincorporação das questões do meio ambiente nas políticas de saúde, e a integração dos objetivos da saúde ambiental numa ampla estratégia de desenvolvimento sustentável. Uma abordagem mais integrada, com mecanismos intersetoriais que possibilitem um diálogo amplo entre as partes, trará enormes benefícios na conquista de melhores condições de vida nas cidades. A saúde ambiental hoje tem o desafio de promover uma melhor qualidade de vida e saúde nas cidades e a oportunidade de enfrentar o absurdo quadro de exclusão social, sob a perspectiva da eqüidade.In a matter of few years there will be more urban than rural dwellers worldwide. The rapid urbanisation lacking adequate control and regulatory mechanisms typical of developing countries, brought along huge effects to the health of the population Environmental problems traditionally related to poverty and underdevelopment such as insufficient provision of sanitation services, waste collection and disposal, and precarious housing conditions, are now added to environmental problems considered of "modern life" such as the

  10. Order of age at onset for substance use, substance use disorder, conduct disorder and psychiatric illness

    DEFF Research Database (Denmark)

    Guldager, Steen; Linneberg, Inger Holm; Hesse, Morten

    2012-01-01

    and social phobia. Of patients reporting an age at onset for SUD and conduct disorder, 84% reported that age at onset was earliest for conduct disorder. Of patients reporting an age at onset for both any non-substance related axis I disorder and any substance related disorder, age at onset was earliest...

  11. Doenças do trabalho e benefícios previdenciários relacionados à saúde, Bahia, 2000 Enfermedades del trabajo y beneficios de la previsión relacionados a la salud, Bahia (Brasil, 2000 Work-related diseases and health-related compensation claims, Northeastern Brazil, 2000

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    Norma Suely Souto Souza

    2008-08-01

    Full Text Available OBJETIVO: Estimar a contribuição das doenças relacionadas ao trabalho nos afastamentos por problemas de saúde em geral e ocupacionais. MÉTODOS: Foram analisados dados sociodemográficos, ocupacionais e de saúde referentes a 29.658 registros dos benefícios por incapacidade temporária concedidos por agravos à saúde pelo Instituto Nacional do Seguro Social, no Estado da Bahia, em 2000. Foram considerados casos todos os diagnósticos clínicos constantes da CID-10, com exceção das causas externas e fatores que influenciam o contato com os serviços de saúde. A vinculação do diagnóstico com a ocupação baseou-se no código CID-10 e se a espécie do benefício era "acidentária". RESULTADOS: Dentre os benefícios, 3,1% foram concedidos para doenças do trabalho: 70% eram doenças do sistema osteomuscular e do tecido conjuntivo e 14,5% do sistema nervoso. No geral, benefícios concedidos numa freqüência maior que o dobro da esperada foram: para tenossinovites na indústria da transformação (Razão de Proporção-RP=2,70, síndrome do túnel do carpo na intermediação financeira (RP=2,43 e transtornos do disco lombar no ramo de transporte, correio e telecomunicações (RP=2,17. Entretanto, não foi estabelecido nexo causal para estas doenças, nesses ramos de atividade, em percentual significativo de benefícios. CONCLUSÕES: Os resultados sugerem a existência de possíveis fatores de risco ocupacionais para enfermidades nesses ramos de atividade, como também o sub-registro da vinculação das patologias com o trabalho, camuflando a responsabilidade das empresas e a perspectiva de prevenção pela reorganização do trabalho.OBJETIVO: Estimar la contribución de las enfermedades relacionadas al trabajo en las licencias por problemas de salud en general y ocupacionales. MÉTODOS: Fueron analizados datos sociodemográficos, ocupacionales y de salud referentes a 29.658 registros de los beneficios por incapacidad temporal concedidos

  12. 43例重复异位妊娠发病相关因素分析%Analysis of the Relative Factors of the Onset of Repeated Ectopic Pregnancy

    Institute of Scientific and Technical Information of China (English)

    莫培培

    2011-01-01

    Objective To determine the relative factors of the onset of repeated ectopic pregnancy ( REP ).Methods In this paper,the clinical data of 43 cases with REP, the relationship between the treatment methods of the initial treatment of ectopic pregnancy ( EP )and the location of repeat ectopic pregnancy,the treatment of REP were analysed retrospectively.Results The incidence rate of REP was 13.56% ( 43/317 ).Every cases had chronic pelvic inflammatory disease history, and 37 cases had infertility history.38 cases had miscarriage history.Most REP happened in the last three years from the first time of ectopic pregnancy happened.The initial treatment and pelvic inflammation have influence on EP.Conclusion The risk factors of onset of REP involves several aspects as follows :repeated miscarriages, pelvic inflammation and infertility,etc.The initial treatment of ectopic pregnancy closely related to REP.%目的分析重复异位妊娠(REP)的发病相关因素.方法回顾性分析43例REP患者的临床资料,首次异位妊娠(EP)的治疗方法与REP发生部位的关系及REP的治疗情况.结果 REP的发生率为13.56%,所有患者都有盆腔炎史,37例有不孕症病史;既往有流产或宫腔操作史38例.多发生在距上次EP发生3年内,与首次EP的治疗方式有关,盆腔炎对REP有影响.结论 REP的发病相关因素是多方面的,反复流产、盆腔炎和不孕症是常见因素,与首次EP的治疗方式密切相关.

  13. Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice.

    Science.gov (United States)

    Tjaden, Lidwien A; Grootenhuis, Martha A; Noordzij, Marlies; Groothoff, Jaap W

    2016-10-01

    Health-related quality of life (HRQoL) is increasingly recognized as a key outcome in both clinical and research settings in the pediatric population with end-stage renal disease (ESRD). This review aims to: (1) summarize the current knowledge on HRQoL and socioprofessional outcomes and (2) provide strategies for incorporation of HRQoL assessment into clinical practice. Studies report that pediatric patients with ESRD have significantly lower HRQoL scores compared with children with other chronic diseases. Patients treated by dialysis are at particularly high risk for impaired HRQoL. Furthermore, patients more often have impaired neurocognitive functioning and lower academic achievement. Important determinants of impaired HRQoL include medical factors (i.e., receiving dialysis, disabling comorbidities, cosmetic side effects, stunted growth), sociodemographic factors (i.e., female gender, non-Western background) and psychosocial factors (i.e., noneffective coping strategies). Contrary to the situation in childhood, adult survivors of pediatric ESRD report a normal mental HRQoL. Despite this subjective feeling of well-being, these patients have on average experienced significantly more difficulties in completing their education, developing intimate relationships, and securing employment. Several medical and psychosocial strategies may potentially improve HRQoL in children with ESRD. Regular assessment of HRQoL and neurocognitive functioning in order to identify areas in which therapies and interventions may be required should be part of standard clinical care.

  14. Relationship Between Early-onset Preeclampsia and Pregnancy Outcome and the Analysis of the Related Factors%早发型子痫前期与妊娠结局的关系及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    蔡建华; 王桂英; 李晓静; 李学军

    2014-01-01

    目的 探讨早发型(妊娠<34周)子痫前期与患者妊娠结局的关系以及明确发生早发型子痫前期的相关因素。方法 回顾性分析2008年1月至2013年1月在本院妇产科进行分娩的纳入符合研究标准的孕产妇25360例的临床资料,对发生早发型子痫前期的孕妇的相关因素进行分析,并对妊娠结局的影响进行分析。结果 早发型子痫前期的孕妇有96例,占0.37%,其中12例在妊娠34周后分娩。孕妇年龄≥35岁( P =0.006;95% CI ,1.309~5.135)、初产( P ≤0.001;95% CI ,2.525~5.052)、糖尿病( P ≤0.001;95% CI ,2.029~8.669)、慢性高血压( P ≤0.001;95% CI ,9.112~37.303)、先天性异常( P ≤0.001;95%C I ,2.632~11.222)是早发型子痫前期的高危因素。早发型子痫前期患者在围产期发生不良结果较非早发型子痫前期患者严重,其中与新生儿病死相关因素包括:胎死、小于胎龄儿、围产期新生儿死亡。结论 依据早发型子痫前期的相关因素以及可能的妊娠结局,可以尽早区别孕产妇情况和预防干预妊娠结局。%Objective] To explore the relationship between early‐onset (< 34 weeks of gestation) pre‐eclampsia and pregnancy outcome in order to identify the associated factors of early‐onset preeclampsia .[Methods]Clinical data of 25360 pregnant and lying‐in women who were enrolled in the study of gynecological and obstetrical department in our hospital from Jan .2008 to Jan .2013 were analyzed retrospectively .The cor‐related factors of early‐onset preeclampsia were analyzed .The influence on pregnancy outcome was analyzed .[Results] There were 96 pregnant women with early‐onset preeclampsia(0 .37% ) .Among them ,12 women delivered after 34 weeks of gestation .The maternal age(≥35 years old ,P=0 .006 ,95% CI ,1 .309~5 .135) , primiparity( P ≤0 .001 ,95% CI ,2 .525

  15. Simultaneous Estimation of Geophysical Parameters with Microwave Radiometer Data based on Accelerated Simulated Annealing: SA

    Directory of Open Access Journals (Sweden)

    Kohei Arai

    2012-07-01

    Full Text Available Method for geophysical parameter estimations with microwave radiometer data based on Simulated Annealing: SA is proposed. Geophysical parameters which are estimated with microwave radiometer data are closely related each other. Therefore simultaneous estimation makes constraints in accordance with the relations. On the other hand, SA requires huge computer resources for convergence. In order to accelerate convergence process, oscillated decreasing function is proposed for cool down function. Experimental results show that remarkable improvements are observed for geophysical parameter estimations.

  16. Conhecimentos, atitudes e práticas dos médicos pediatras em relação à saúde bucal Knowledge, attitudes and practice of pediatricians in relation to oral health

    Directory of Open Access Journals (Sweden)

    Maria do Carmo Matias FREIRE

    2000-03-01

    Full Text Available A equipe de saúde tem um importante papel na educação em saúde bucal da população. O objetivo do presente estudo foi investigar o nível de conhecimento, atitudes e práticas dos médicos pediatras em relação à cárie. Um total de 96 médicos pediatras que atuam no serviço público de Goiânia - GO responderam ao questionário. Destes, 94,8% e 96,9% relataram que possuem informação sobre a etiologia e prevenção da cárie, respectivamente; e 88,5% examinam os dentes durante suas consultas e orientam os pais das crianças. A higiene oral e o uso de flúor foram os métodos de prevenção mais citados, enquanto o papel do açúcar na etiologia da cárie foi reconhecido por poucos médicos. A maioria concordaram que os pediatras, juntamente com os cirurgiões-dentistas, devem atuar na educação em saúde bucal dos pacientes, mas apenas 24,0% da amostra consideraram seu próprio nível de informação satisfatório. Concluiu-se que há necessidade de um maior esclarecimento aos médicos pediatras sobre o papel da dieta na cárie dental, para que informações mais corretas sejam repassadas aos pais.Primary health workers have an important role in oral health promotion. The aim of this study was to investigate knowledge, attitudes and practice of pediatricians regarding dental caries. A total of 96 pediatricians working in the public health service of Goiânia - GO, Brazil, answered the questionnaire. From these, 94.8% and 96.9% reported that they were aware of dental caries etiology and prevention, respectively; and 89.6% examined children’s teeth in their consultations and gave advice to the parents. Oral hygiene and fluoride were the most commonly mentioned methods of prevention; only a few pediatricians were aware of the role of sugars in the etiology of dental caries. The majority agreed that pediatricians as well as dentists should play a role in oral health education of patients, but only 24.0% said that their own level of

  17. Spondyloarthritis with onset after age 45.

    Science.gov (United States)

    Olivieri, Ignazio; D'Angelo, Salvatore; Padula, Angela; Leccese, Pietro; Palazzi, Carlo

    2013-12-01

    The ASAS (Assessment in SpondyloArtrhritis international Society) classification criteria for axial and peripheral spondyloarthritis permit to classify patients with age at disease onset less than 45 years. Nevertheless, these two forms of spondyloarthritis may begin after the age of 45. With the longer duration of the life expectancy, patients with this late-onset form of spondyloarthritis may be more frequently recognized in the near future. A small percentage (ranging from 3.5 to 6 %) of patients with axial SpA, as defined by the modified New York criteria, have onset of their disease after 45 years of age. Relatively more frequent is the late onset form of peripheral spondyloarthritis with the characteristics of undifferentiated spondyloarthritis. Its clinical spectrum is as broad as it is in children and very young adults. Psoriatic arthritis frequently begins over the age of 45 and occasionally after the age of 60. Some old studies had suggested than elderly-onset psoriatic arthritis is more severe than younger-onset disease, but a recent study found no such difference, and further studies are needed.

  18. Late onset globoid cell leukodystrophy.

    Science.gov (United States)

    Grewal, R P; Petronas, N; Barton, N W

    1991-11-01

    A 29 year old male with onset of globoid cell leukodystrophy at age 14 is described. This is the first case of enzymatically confirmed globoid cell leukodystrophy with onset of symptoms after the age of ten. This patient is unique because of the late onset and slow progression and extends the clinical spectrum of globoid cell leukodystrophy.

  19. Adult-onset tic disorders

    NARCIS (Netherlands)

    Eapen, [No Value; Lees, AJ; Lakke, JPWF; Trimble, MR; Robertson, MM

    2002-01-01

    We report on 8 patients with adult-onset motor tics and vocalisations. Three had compulsive tendencies in childhood and 3 had a family history of tics or obsessive-compulsive behaviour. In comparison with DSM-classified, younger-onset Gilles de la Tourette syndrome, adult-onset tic disorders are mor

  20. Late-onset hypogonadism

    Directory of Open Access Journals (Sweden)

    Piotr Dudek

    2017-06-01

    Full Text Available In Poland, the number of men over the age of 50 years exceeds 6 million. It is estimated that about 2-6% of this population develops symptoms of late-onset hypogonadism (LOH. In men, testosterone deficiency increases slightly with age. LOH is a clinically and biochemically defined disease of older men with serum testosterone level below the reference parameters of younger healthy men and with symptoms of testosterone deficiency, manifested by pronounced disturbances of quality of life and harmful effects on multiple organ systems. Testosterone replacement therapy may give several benefits regarding body composition, metabolic control, and psychological and sexual parameters.

  1. Participação política e cotidiano da gestão em saúde: um ensaio sobre a potencialidade formativa das relações institucionais Political participation and routine of health care management: an essay on the formative potentiality in institutional relations

    Directory of Open Access Journals (Sweden)

    Francini Lube Guizardi

    2012-06-01

    Full Text Available Este ensaio pretende contribuir para o debate sobre a participação política na experiência do SUS no Brasil. Nele é problematizado o espaço que tem sido reservado para seu exercício efetivo, procurando refletir sobre a atuação dos diferentes sujeitos envolvidos com a produção de políticas de saúde. Parte-se da hipótese de que as instituições de saúde permanecem assentadas na objetivação da dimensão política inerente à vida humana, o que traz limites significativos para a concretização de um sistema de saúde fundado em valores democráticos e universais. O ensaio trabalha teoricamente as relações entre política, cotidiano e linguagem, a partir de conceitos de Hannah Arendt, Antonio Negri e do círculo de Bakhtin. Em seguida, é discutido o problema da cultura política que perpassa as instituições de saúde, considerando que o recurso a capacitações ou estratégias de representação de interesses não tem sido eficaz em solucioná-lo. Nesta perspectiva, são abordadas as potencialidades formativas das relações institucionais, utilizando como referência a Política de Educação Permanente. Como conclusão, o ensaio procura evidenciar que a articulação de novas configurações para a participação política nas instituições de saúde requer a discussão sobre o que seja e o que se deseja da ação de participar, sem o que dificilmente os espaços institucionalizados de participação deixarão de reproduzir as relações de força que os sujeitos historicamente vivenciam no cotidiano do sistema de saúde.This essay aims to contribute to the debate on political participation in the experience of the Brazilian Unified Health System. It discusses the space reserved for its effective exercise, trying to reflect on the actions of different actors involved in the production of health policies. The analysis supports the hypothesis that health institutions remain attached in the objectification of the political

  2. Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice

    Science.gov (United States)

    2012-01-01

    Background Frequent consumption of a diet high in fat and sucrose contributes to lifestyle-related diseases. However, limited information is available regarding the short-term effects of such a diet on the onset of obesity-associated metabolic abnormalities. Methods Male C57BL/6 J mice were divided into two groups and fed a standard chow diet (control group) or a high fat–high sucrose diet containing 21% fat and 34% sucrose (HF–HS diet group) for 2 or 4 weeks. Results The HF–HS diet significantly induced body weight gain beginning at week 1 and similarly increased mesenteric white adipose tissue weight and plasma insulin levels at weeks 2 and 4. Plasma resistin levels were notably elevated after feeding with the HF–HS diet for 4 weeks. Measurement of hepatic triglycerides and Oil Red O staining clearly indicated increased hepatic lipid accumulation in response to the HF–HS diet as early as 2 weeks. Quantitative PCR analysis of liver and white adipose tissue indicated that, starting at week 2, the HF–HS diet upregulated mRNA expression from genes involved in lipid metabolism and inflammation and downregulated genes involved in insulin signalling. Although plasma cholesterol levels were also rapidly increased by the HF–HS diet, no differences were found between the control and HF–HS diet–fed animals in the expression of key genes involved in cholesterol biosynthesis. Conclusions Our study demonstrates that the rapid onset of hepatosteatosis, adipose tissue hypertrophy and hyperinsulinemia by ingestion of a diet high in fat and sucrose may possibly be due to the rapid response of lipogenic, insulin signalling and inflammatory genes. PMID:22762794

  3. Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice

    Directory of Open Access Journals (Sweden)

    Yang Zhi-Hong

    2012-07-01

    Full Text Available Abstract Background Frequent consumption of a diet high in fat and sucrose contributes to lifestyle-related diseases. However, limited information is available regarding the short-term effects of such a diet on the onset of obesity-associated metabolic abnormalities. Methods Male C57BL/6 J mice were divided into two groups and fed a standard chow diet (control group or a high fat–high sucrose diet containing 21% fat and 34% sucrose (HF–HS diet group for 2 or 4 weeks. Results The HF–HS diet significantly induced body weight gain beginning at week 1 and similarly increased mesenteric white adipose tissue weight and plasma insulin levels at weeks 2 and 4. Plasma resistin levels were notably elevated after feeding with the HF–HS diet for 4 weeks. Measurement of hepatic triglycerides and Oil Red O staining clearly indicated increased hepatic lipid accumulation in response to the HF–HS diet as early as 2 weeks. Quantitative PCR analysis of liver and white adipose tissue indicated that, starting at week 2, the HF–HS diet upregulated mRNA expression from genes involved in lipid metabolism and inflammation and downregulated genes involved in insulin signalling. Although plasma cholesterol levels were also rapidly increased by the HF–HS diet, no differences were found between the control and HF–HS diet–fed animals in the expression of key genes involved in cholesterol biosynthesis. Conclusions Our study demonstrates that the rapid onset of hepatosteatosis, adipose tissue hypertrophy and hyperinsulinemia by ingestion of a diet high in fat and sucrose may possibly be due to the rapid response of lipogenic, insulin signalling and inflammatory genes.

  4. HSV-1/HSV-2 Infection-Related Cancers in Bantu Populations Driving HIV-1 Prevalence in Africa: Tracking the Origin of AIDS at the Onset of the 20th Century

    Directory of Open Access Journals (Sweden)

    Jacqueline Le Goaster

    2016-11-01

    Full Text Available Introduction: At the onset of the 20th century, ancient clinical observations of cancer epidemics in Bantu populations of Sub-Saharan Africa were discovered. They were reported from 1914 to 1960, but remained unexplained. In 1983, in San Francisco, Calif., USA, cancer epidemics were related to infections by the human immunodeficiency virus type 1 (HIV-1 known as AIDS disease. Yet since 1996, it is known that HIV-1 strains are not the only ones involved. In Sub-Saharan Africa, recurrent orobuccal herpes simplex virus type 1 (HSV-1 and genital recurrent herpes simplex virus type 2 (HSV-2 appeared many times prior to infection by HIV-1. Case Reports: Data on these ancient medical observations regarding African cancer epidemics can today be referred to as the relationship between the unfortunate immune deficiency of herpes in Bantu populations and HIV-1 viral strains. For centuries, the Bantu populations dispersed in forests were living in close proximity to chimpanzees infected by simian immunodeficiency virus (SIV and were exposed to SIV contamination which became HIV-1 in human beings. Presently, these unexplained Bantu cancer epidemics can be linked to the viral partnership of HSV-1/HSV-2 to HIV-1 strains. Conclusion: The key issue is now to prevent HSV-1/HSV-2 diseases related to HIV-1. An anti-herpes treatment administered early during childhood to Bantu populations will offer a mean of preventing herpes diseases related to HIV-1 infection and hence avoid cancer epidemics.

  5. Prefeitos eleitos, descentralização na saúde e os compromissos com o SUS

    Directory of Open Access Journals (Sweden)

    Lenaura de Vasconcelos Costa Lobato

    Full Text Available O artigo analisa a municipalização na saúde por meio das proposições para a política de saúde de prefeitos eleitos no ano de 2012. Realizou-se análise documental das plataformas de governo dos então candidatos e de documentos oficiais da política e da gestão municipais de saúde - Relatórios das Conferências Municipais de Saúde e Planos Municipais de Saúde - de 24 municípios brasileiros nas cinco regiões do País. Os resultados indicam que os programas das candidaturas, em geral, incorporam a defesa do direito à saúde, embora principalmente através da ampliação da oferta de serviços médicos.

  6. The preliminary study of autophagy induction of SA and MeSA by confocal

    Science.gov (United States)

    Yun, Lijuan; Chen, Wenli

    2010-02-01

    Autophagy appears to be a highly conserved process from unicellular to multicellular eukaryotes which contributes to the equilibrium of intracelluar environment. While it would be harmful to the cells when it is excessive by inducing programmed cell death (PCD). It is a protein degradation process in which cells recycle cytoplasmic contents when subjected to environmental stress conditions or during certain stages of development. Previous studies have demonstrated autophagy can be induced during abiotic or biotic stresses. salicylic acid (SA) and methyl salicytic (MeSA) are endogenous signal molecules. We found SA and MeSA can induce autophagy in Arabidopsis thaliana respectively. While autophagy was not induced by SA or MeSA in tobacco suspension cells under the same concentration and period. The differences in stuctures or physiological states may contribute to the results.

  7. Efeito Paidéia e o campo da saúde: reflexões sobre a relação entre o sujeito e o mundo da vida The Paideia effect and the health field: thoughts on the relation between subject and life-world

    Directory of Open Access Journals (Sweden)

    Gastão Wagner de Souza Campos

    2006-03-01

    Full Text Available Este ensaio reflete sobre o modo como o método Paidéia lida com a relação entre a constituição de sujeitos e o mundo da vida. Apresenta alguns núcleos temáticos utilizados para analisar essa relação em situações concretas. Discute critérios para avaliar a noção de desenvolvimento político ou institucional. Comenta implicações da adoção desta metodologia no campo da saúde, especificamente para a prática da clínica ou da saúde pública.This essay reflects on how the Paideia method handles the relation between the development of subjects and the life-world, presenting a few concepts used in its analysis in actual situations. The essay also discusses criteria for evaluating political or institutional development and comments on the implications of the adoption of this method on the health field - especially on clinical practice and public health.

  8. Algumas idéias sobre a relação educação e comunicação no âmbito da Saúde A few ideas on the relation education and communication in the field of Health

    Directory of Open Access Journals (Sweden)

    Ausonia Favorido Donato

    2003-12-01

    Full Text Available O presente artigo discute alguns conceitos acerca da articulação entre Educação e Comunicação no âmbito da Saúde através da discussão de duas experiências educacionais com jovens e adultos. Tem início pela circunscrição do constructo "ambito da Saúde" não apenas como um locus a partir do qual seja possível localizar fenômenos relacionados à Saúde, mas também como uma instância social e historicamente construída por indivíduos que estabelecem entre si relações de troca e de poder. A partir do elemento social comum, articulam-se os aspectos relacionados à Educação e à Comunicação. Quanto à Comunicação, tencionou-se abordá-la não em sua dimensão midiática latu senso mas, sim, a partir de sua condição de produção de sentido social no interior da subjetividade, utilizando para isso alguns conceitos do linguísta russo Mikhail Bakhtin. No tocante à Educação, destacou-se a articulação entre as várias dimensões do processo ensino-aprendizagem, esquematizadas em seus campos de saber. Enfim, pudemos verificar que, ao contrário de uma abordagem eminentemente comunicacional dos problemas de Saúde, a contribuição da relação entre Comunicação e Educação, localizada no âmbito da Saúde, faz questionar uma tendência corrente que privilegia as mídias em detrimento da promoção do sujeito.This article discusses some concepts about the link between Education and Communication in the field of Health through the discussion of two educational experiences with youngsters and adults. It begins with the circunscription of the constructed "field of health" not only as a locus from which it is possible to locate phenomena related to Health but also as a social instance and historically made by individuals who establish among themselves exchange and power relationships. Starting with the common social element, the aspects related to Education and Communication get jointed. As for Communication, we meant to

  9. SA3654 Component characterization. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Meir, G.W.

    1996-06-01

    AlliedSignal Inc., Federal Manufacturing & Technologies (FM&T), was provided with production capability assurance program (PCAP) funding to develop, characterize, and qualify purchased product components for use on the PRESS-A program. The SA3654, N-Channel, Power MOSFET was identified as a component needing such activity to support PRESS-A. This report presents the characterization activities and results for the SA3654.

  10. SaVi: satellite constellation visualization

    CERN Document Server

    Wood, Lloyd

    2012-01-01

    SaVi, a program for visualizing satellite orbits, movement, and coverage, is maintained at the University of Surrey. This tool has been used for research in academic papers, and by industry companies designing and intending to deploy satellite constellations. It has also proven useful for demonstrating aspects of satellite constellations and their geometry, coverage and movement for educational and teaching purposes. SaVi is introduced and described briefly here.

  11. Åsa portreed / Åsa Johannesson ; intervjueerinud Kaisa Eiche

    Index Scriptorium Estoniae

    Johannesson, Åsa

    2009-01-01

    Rootsi fotograafist Åsa Johannessonist, kelle portreefotode seeriat "Portraits of Her" eksponeeriti Riias toimunud kunstiüritusel "MOMENT". Tema õpingutest ja elust Londonis. Naiselikkusest ja mehelikkusest

  12. Åsa portreed / Åsa Johannesson ; intervjueerinud Kaisa Eiche

    Index Scriptorium Estoniae

    Johannesson, Åsa

    2009-01-01

    Rootsi fotograafist Åsa Johannessonist, kelle portreefotode seeriat "Portraits of Her" eksponeeriti Riias toimunud kunstiüritusel "MOMENT". Tema õpingutest ja elust Londonis. Naiselikkusest ja mehelikkusest

  13. Is the time between onset of pain and restoration of patency of infarct-related artery shortened in patients with myocardial infarction? The effects of the Kielce Region System for Optimal Management of Acute Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Marcin Sadowski

    2014-09-01

    Full Text Available Introduction : The importance of delay in the restoration of infarct-related artery patency in patients with myocardial infarction was discussed, and actions were undertaken in the Kielce Region aimed at shortening this time within the System for Optimal Management of Acute Myocardial Infarction. Aim of the research: To evaluate the effectiveness of shortening time delays during transport of patients and diagnostics of myocardial infarction in the Kielce Region. Material and methods: Time delays were analysed in 5,934 patients with ST-segment elevation myocardial infarction (STEMI, hospitalised in cardiology wards with interventional cardiology on 24-hour duty, during the period 2008–2012. Time delays were analysed between the onset of myocardial infarction pain and undertaking treatment – T1 and T2 time – within which a patient with myocardial infarction, after admission to hospital, has intervention performed on infarct-related coronary artery. Results : During the period 2008–2012, the median T1 time was successfully shortened from 355 to 203 min, and the T2 time from 101 to 48 min. Conclusions: The effectiveness of the system was confirmed, and the necessity for further improvement of the system indicated.

  14. Avaliações de Programas Públicos Realizadas pelo TCU na Área de Saúde = Determinants of the Conformity Level of Evidences Related to the Disclosure CPC 27 in Companies of the New BM&FBOVESPA Market

    Directory of Open Access Journals (Sweden)

    Célio da Costa Barros

    2015-04-01

    Full Text Available A Saúde é um direito fundamental do ser humano, garantido constitucionalmente pelo Estado, mediante a implementação de políticas públicas para o setor, visando a promover o bem-estar físico, mental e social da coletividade. A pesquisa buscou analisar as avaliações de programas realizadas pelo Tribunal de Contas da União (TCU, única Entidade de Fiscalização Superior (EFS no Brasil, no período de 2000-2012, revelando os critérios no manuseio dos dados, bem como os padrões utilizados pelo órgão de controle externo. A pesquisa é exploratória, com abordagem qualitativa-quantitativa e estudo de caso. Os resultados revelam a realização de dezessete avaliações que contaram com 121 auditores, 65,29% do gênero masculino, e o emprego de dezessete tipos de técnicas de diagnóstico, predominando a entrevista e a pesquisa postal/eletrônica. Conclui-se que as avaliações de programas realizadas pelo TCU converteram-se em subsídios para o aperfeiçoamento dos rumos da gestão pública na área da saúde, uma vez que delas resultaram 305 recomendações. O TCU demonstrou a capacidade de concretizar até quatro avaliações anuais nessa área, e os monitoramentos, realizados em número de dez, foram considerados tímidos e impontuais, cobrando da Administração Pública Federal Brasileira recomendações realizadas até 2007. This article aims at identifying the factors that explain the level of disclosure concerning the CPC 27 - Fixed Assets, for companies listed on the New Market segment of Corporate Governance of BM&FBovespa. The probable determinants are considered the size variations, the total assets, debt and return on assets. The study is characterized as descriptive, carried out through documentary analysis and quantitative approach. The population is made of 109 companies in 2011, covering a sample of 106 companies. For data collection a checklist which consists of 17 items based in IAS 27 were designed. The analysis

  15. Early-Onset Dementia

    DEFF Research Database (Denmark)

    Konijnenberg, Elles; Fereshtehnejad, Seyed-Mohammad; Kate, Mara Ten;

    2017-01-01

    BACKGROUND: Early-onset dementia (EOD) is a rare condition, with an often atypical clinical presentation, and it may therefore be challenging to diagnose. Specialized memory clinics vary in the type of patients seen, diagnostic procedures applied, and the pharmacological treatment given. The aim...... of this study was to investigate quality-of-care indicators in subjects with EOD from 3 tertiary memory clinics in 3 European countries. METHODS: We included 1325 newly diagnosed EOD patients, ages 65 years or younger, between January 1, 2007 and December 31, 2013, from the Danish Dementia Registry...... (Rigshospitalet, Copenhagen), the Swedish Dementia Registry ("SveDem", Karolinska University Hospital, Stockholm), and the Amsterdam Dementia Cohort (VU University Medical Center). RESULTS: The frequency of EOD among all dementia patients was significantly lower in Copenhagen (410, 20%) and Stockholm (284, 21...

  16. Condutas de saúde entre universitários: diferenças entre gêneros Health-related behavior in a sample of Brazilian college students: gender differences

    Directory of Open Access Journals (Sweden)

    Viviane Colares

    2009-03-01

    Full Text Available Este estudo investigou diferenças entre os gêneros nas condutas de saúde de universitários em final de curso. A amostra foi composta de 382 estudantes de universidades públicas do Estado de Pernambuco, Brasil, com idade entre 20 e 29 anos. Os dados foram coletados mediante a aplicação do questionário National College Health Risk Behavior Survey, validado previamente para o português. Foram utilizadas técnicas de estatística descritiva e inferencial. Para análise de associação foram utilizados teste qui-quadrado ou exato de Fisher. Os resultados foram considerados significantes para p This study investigated whether undergraduate students' health-risk behaviors differed according to gender. The sample consisted of 382 subjects, aged 20-29 years, from public universities in Pernambuco State, Brazil. Data were collected using the National College Health Risk Behavior Survey, previously validated in Portuguese. Descriptive and inferential statistical techniques were used. Associations were analyzed with the chi-square test or Fisher's exact test. Statistical significance was set at p < 0.05. In general, females engaged in the following risk behaviors less frequently than males: alcohol consumption (p = 0.005, smoking (p = 0.002, experimenting with marijuana (p = 0.002, consumption of inhalants (p < 0.001, steroid use (p = 0.003, carrying weapons (p = 0.001, and involvement in physical fights (p = 0.014. Meanwhile, female students displayed more concern about losing or maintaining weight, although they exercised less frequently than males. The findings thus showed statistically different health behaviors between genders. In conclusion, different approaches need to be used for the two genders.

  17. Planejamento, gestão e ações à saúde do homem na estratégia de saúde da família

    Directory of Open Access Journals (Sweden)

    Leonardo Peixoto Pereira

    2014-12-01

    Full Text Available Objetivo: Analisar a situação do planejamento, da gestão e das ações de saúde diante da perspectiva de implantação da Política de Atenção à Saúde do Homem na Estratégia de Saúde da Família no município de Jequié. Métodos: Tratou-se de um estudo qualitativo. Entrevistaram-se gestores municipais dos serviços de saúde, profissionais de saúde da Estratégia de Saúde da Família e homens com 25 a 59 anos residentes nas áreas adscritas das unidades de saúde estudadas; realizou-se análise documental do Plano de Saúde e Relatórios de Gestão na Secretaria Municipal de Saúde e análise de conteúdo, modalidade temática. Resultados: Não há atividades assistenciais; de prevenção e promoção à saúde masculina desenvolvidas e os processos de implantação da atenção à saúde do homem encontram-se incipientes. Conclusão: É preciso ampliar o diálogo e reorganizar as estratégias de planejamento e gestão para compreender as reais necessidades masculina e articular com os atores envolvidos a implantação das ações de atenção à saúde do homem.

  18. O debate sobre educação em saúde no âmbito do Conselho Municipal de Saúde de Vitória, ES, Brasil

    Directory of Open Access Journals (Sweden)

    Welington Serra Lazarini

    2014-12-01

    Full Text Available Analisou-se a relação entre educação em saúde e a política de participação e controle social em saúde da Secretaria Municipal de Saúde de Vitória-ES, Brasil, entre 2005 e 2012. Realizou-se análise documental nos planos municipais de saúde, relatórios de gestão e em 139 atas do Conselho Municipal de Saúde. Evidenciou-se que a gestão orientou sua política pela participação, mas restringiu-se ao Conselho Municipal de Saúde. A educação em saúde foi tratada pontualmente durante as reuniões. Quando debatida, foi como modelo tradicional, configurando-se em estratégia para vigilância. A Educação Popular em Saúde foi mencionada no segundo governo, mas sem a redefinição das práticas. Sinaliza-se a necessidade de reconhecer as diferentes formas de participação social em Vitória e ampliar o debate acerca do modelo dialógico da educação em saúde.

  19. Brain structure abnormalities in early-onset and adolescent-onset conduct disorder.

    Science.gov (United States)

    Fairchild, Graeme; Passamonti, Luca; Hurford, Georgina; Hagan, Cindy C; von dem Hagen, Elisabeth A H; van Goozen, Stephanie H M; Goodyer, Ian M; Calder, Andrew J

    2011-06-01

    The developmental taxonomic theory proposes that neurodevelopmental factors play a critical role in the etiology of early-onset conduct disorder, whereas adolescent-onset conduct disorder arises as a result of social mimicry of deviant peers. Recent studies have challenged this theory by demonstrating that adolescents with both early- and adolescent-onset forms of conduct disorder show impaired emotional learning and abnormal neural activation during facial expression processing. The present study extends this work by investigating brain structure in both subtypes of conduct disorder. Voxel-based morphometry was used to compare gray matter volumes in four regions of interest (amygdala, insula, anterior cingulate, and orbitofrontal cortex) in male adolescents with early-onset (N=36) or adolescent-onset (N=27) conduct disorder and in healthy comparison subjects (N=27). Whole-brain structural analyses were also performed. The combined conduct disorder group displayed gray matter volume reductions in the bilateral amygdala, extending into the insula, relative to healthy comparison subjects. Separate comparisons between healthy subjects and each conduct disorder subgroup revealed lower amygdala volume in both subgroups and reduced right insula volume in the adolescent-onset subgroup. Regression analyses within the conduct disorder subjects alone demonstrated a negative correlation between conduct disorder symptoms and right insula volume. The results demonstrate that gray matter volume reductions in brain regions involved in processing socioemotional stimuli are associated with conduct disorder, regardless of age of onset. Brain structural abnormalities may contribute to the emergence of adolescent-onset as well as early-onset conduct disorder.

  20. Late onset reversible cortical blindness following electrocution.

    Science.gov (United States)

    Chauhan, Bhumir; Philip, Vivek J; Shankar, Udaya C

    2015-12-01

    An elderly gentleman presented with acute onset of bilateral visual blurring and generalized headache after 1 week post electrocution injury. Clinically, the symptoms were attributed to cortical lesion. Magnetic resonance imaging (MRI) of brain revealed bilaterally symmetrical diffusion restriction in parietal and occipital areas. Treatment with intravenous steroids resulted in remarkable improvement in symptoms. Neurological injury secondary to electrocution is a well described entity having a variety of clinical presentation. We put forward our experience with this unique case presenting as post electrocution delayed onset of visual symptoms. Discussion and review of literature related to this clinical entity will also be presented.

  1. Respiratory Infections Precede Adult-Onset Asthma

    OpenAIRE

    2011-01-01

    BACKGROUND: Respiratory infections in early life are associated with an increased risk of developing asthma but there is little evidence on the role of infections for onset of asthma in adults. The objective of this study was to assess the relation of the occurrence of respiratory infections in the past 12 months to adult-onset asthma in a population-based incident case-control study of adults 21-63 years of age. METHODS/PRINCIPAL FINDINGS: We recruited all new clinically diagnosed cases of a...

  2. Related factors of stroke onset in patients with sleep apnea syndrome%睡眠呼吸暂停综合征合并卒中的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    李友梅

    2016-01-01

    Objective:To investigate the expressions of serum inflammatory markers and markers for endothelial function in patients with sleep apnea syndrome (SAS) complicated with stroke, and explore the risk factors related to stroke onset in SAS patients. Methods:This study included 35 patients with simple SAS and 38 SAS patients complicated with stroke. The expression levels of serum endothelial nitric oxide synthase, malondialdehyde (MDA) and tumor necrosis factorα (TNFα) were detected and compared between the simple SAS patients and the SAS patients complicated with stroke. The related factors of stroke onset in patients with SAS were examined. Results:The expression levels of serum endothelial nitric oxide synthase, MDA and TNFαin SAS patients complicated with stroke were significantly higher than those in simple SAS patients (allP = 0.000). Univariate analysis showed that gender (P = 0.012), age (P = 0.009), the course of SAS (P = 0.000) and the history of hypertension (P = 0.000) were associated with stroke onset in SAS patients. Multivariate analysis showed that the course of SAS [hazard ratio: 9.12 (95% confidence interval: 2.15-13.88);P = 0.000] and the history of hypertension [hazard ratio: 5.05 (95% confidence interval: 2.74-10.52);P = 0.000] were the independent factors for stroke onset in SAS patients. Conclusion:The expression levels of serum inflammatory markers and markers for endothelial function in SAS patients complicated with stroke are increased, indicating the further dysfunction of endothelial cells. The course of SAS more than one year and the history of hypertension are independent risk factors involved in the onset of stroke in SAS patients.%目的:分析睡眠呼吸暂停综合征(sleep apnea syndrome,SAS)合并卒中患者的血清炎性标志物和血管内皮功能指标的表达水平,并探讨与SAS发生卒中相关的危险因素。方法:研究对象包括35例单纯SAS患者以及38例SAS合并卒

  3. M. G.-F. Leclerc, Préfet de la Haute-Savoie lors de sa visite dans le tunnel du LHC au Point 2 avec D. Delikaris, Département Technologie; dans la caverne de l'expérience ALICE avec B. Erazmus, Collaboration ALICE et lors de la signature du livre d'or avec F. Bordry, Chef du Département Technologie. P. Fassnacht, Conseiller au Bureau des Relations internationales présent.

    CERN Multimedia

    Jean-Claude Gadmer

    2013-01-01

    M. G.-F. Leclerc, Préfet de la Haute-Savoie lors de sa visite dans le tunnel du LHC au Point 2 avec D. Delikaris, Département Technologie; dans la caverne de l'expérience ALICE avec B. Erazmus, Collaboration ALICE et lors de la signature du livre d'or avec F. Bordry, Chef du Département Technologie. P. Fassnacht, Conseiller au Bureau des Relations internationales présent.

  4. Competências científico- tecnológicas e cooperação universidade-empresa na saúde Competencias científico-tecnológicas y cooperación Universidad-Empresa en la salud Health-related scientific and technological capabilities and university-industry research collaboration

    Directory of Open Access Journals (Sweden)

    Jorge Britto

    2012-12-01

    Full Text Available OBJETIVO: Analisar a evolução recente das competências científicas na área de saúde, o efeito das linhas de fomento na redução dos desequilíbrios científicos regionais e a interação universidade-empresas entre os grupos de pesquisa em saúde no Brasil. MÉTODOS: As informações utilizadas foram provenientes das bases de dados do Conselho Nacional de Desenvolvimento Científico e Tecnológico, referentes aos anos de 2000 a 2010. Foram calculados indicadores relativos à mobilização de recursos, à estruturação de grupos de pesquisa e à realização de esforços para transferência de conhecimentos entre a esfera científica e o setor empresarial. RESULTADOS: Com base no mapa da distribuição regional das competências técnico-científicas na área de saúde, foram identificados possíveis padrões de especialização científica e os padrões de interação entre a comunidade científica e o setor empresarial. Houve relativa desconcentração espacial dos grupos de pesquisa em saúde e seis áreas de conhecimento eram responsáveis por mais de 6% dos grupos de pesquisa em saúde, pela ordem: Medicina, Saúde Coletiva, Odontologia, Medicina Veterinária, Ecologia e Educação Física. Os incentivos representados pelas linhas de fomento no período 2000-2009 contribuíram para reduzir os desequilíbrios científicos regionais, induzindo o aprofundamento de competências pré-existentes ou, alternativamente, estimulando a descentralização espacial dessas competências. CONCLUSÕES: Ainda persiste uma concentração espacial elevada das competências técnico-científicas em saúde e os incentivos de política têm contribuído apenas parcialmente para reduzir esses desequilíbrios.OBJETIVO: Analizar la evolución reciente de las competencias científicas en el área de la salud, el efecto de las líneas de fomento en la reducción de los desequilibrios científicos regionales y la interacción universidad-empresas entre los

  5. Persisting problems related to race and ethnicity in public health and epidemiology research Problemas persistentes relacionados con la raza y etnia en la investigación en salud pública y epidemiología Problemas persistentes relacionados à raça e etnia na pesquisa em saúde pública e epidemiologia

    Directory of Open Access Journals (Sweden)

    Jean-Claude Moubarac

    2013-02-01

    Full Text Available A recent and comprehensive review of the use of race and ethnicity in research that address health disparities in epidemiology and public health is provided. First it is described the theoretical basis upon which race and ethnicity differ drawing from previous work in anthropology, social science and public health. Second, it is presented a review of 280 articles published in high impacts factor journals in regards to public health and epidemiology from 2009-2011. An analytical grid enabled the examination of conceptual, theoretical and methodological questions related to the use of both concepts. The majority of articles reviewed were grounded in a theoretical framework and provided interpretations from various models. However, key problems identified include a a failure from researchers to differentiate between the concepts of race and ethnicity; b an inappropriate use of racial categories to ascribe ethnicity; c a lack of transparency in the methods used to assess both concepts; and d failure to address limits associated with the construction of racial or ethnic taxonomies and their use. In conclusion, future studies examining health disparities should clearly establish the distinction between race and ethnicity, develop theoretically driven research and address specific questions about the relationships between race, ethnicity and health. One argue that one way to think about ethnicity, race and health is to dichotomize research into two sets of questions about the relationship between human diversity and health.Se realizó revisión reciente y amplia de la utilización de raza y etnia en investigaciones dedicadas a las disparidades de salud en epidemiología y salud pública. Se describió la base teórica sobre cual raza y etnia difieren en los métodos de trabajos en ciencia, antropología social y de salud pública. La revisión fue hecha con base en la selección de artículos publicados en revistas de alto factor de impacto en lo que

  6. A influência da estruturação da mensagem em comportamentos relacionados à saúde: um teste experimental The influence of framing on health-related behaviors: an experimental test

    Directory of Open Access Journals (Sweden)

    Verônica Feder Mayer

    2010-09-01

    Full Text Available Este estudo realizou um teste experimental envolvendo o efeito framing. Segundo a Teoria dos Prospectos, o efeito framing é a possibilidade de influenciar a decisão de um indivíduo sem distorcer a informação ou suprimi-la por meio de mudanças sutis na estruturação do problema. Foi testada a hipótese de que um folheto enfatizando as consequências negativas de não se prevenir contra o estresse seria mais persuasivo do que um folheto que enfatizasse as consequências positivas de se prevenir. Estudos anteriores, que examinaram o efeito framing na estruturação de mensagens persuasivas, produziram resultados variados. Esta pesquisa explorou as explicações teóricas para os resultados obtidos em campanhas relacionadas à saúde. Estudantes brasileiros de programas de pós-graduação foram expostos a um folheto estruturado negativamente, a um folheto estruturado positivamente ou a um folheto simplesmente informativo sobre o estresse. Atitudes em relação às recomendações para prevenir-se contra estresse e as intenções de segui-las foram medidas. Os resultados obtidos indicam maior persuasão do framing negativo.This study performed an experimental test involving the framing effect. According to the Prospect Theory, the framing effect is the possibility of influencing an individual's decision without distorting the information or suppressing it, but by means of subtle changes in the way the problem is presented. We tested the hypothesis that a brochure emphasizing the negative consequences of not protecting oneself against stress would be more persuasive than a brochure emphasizing the positive consequences of this attitude. Prior studies, which examined the framing effect in structuring persuasive messages, have produced varied results. This study explored the theoretical explanations for results obtained in health campaigns. Brazilian postgraduate students were exposed to a negatively structured brochure, a positively structured

  7. Sociologia, medicina e a construção da sociologia da saúde Sociología, medicina y la construcción de la sociología de la salud Sociology, medicine and the construction of health-related sociology

    Directory of Open Access Journals (Sweden)

    Nelson Filice de Barros

    2009-02-01

    Full Text Available Partindo de artigo publicado em 1971 sobre a aproximação entre sociologia e medicina, no Brasil e Reino Unido, foi realizada atualização histórica, com o fim de refletir sobre novas conformações do ensino e pesquisa das ciências sociais e humanas no campo da saúde em ambos os países. A metodologia foi qualitativa, sendo a pesquisa desenvolvida com dados secundários e as reflexões elaboradas a partir da imersão dos autores na realidade brasileira e britânica. Concluiu-se que houve ampliação da interface entre a sociologia e a saúde, embora existam dificuldades antigas e persistentes em relação à estrutura e foco do sistema de saúde, poder na escola médica e cultura estudantil.Partiendo del artículo publicado en 1971 sobre la aproximación entre sociología y medicina, en Brasil y Reino Unido, fue realizada actualización histórica, con el fin de reflexionar sobre nuevas conformaciones de enseñanza y pesquisa de las ciencias sociales y humanas en el campo de la salud en ambos países. La metodología fue cualitativa, siendo la pesquisa desarrollada con datos secundarios y las reflexiones elaboradas a partir de la inmersión de los autores en la realidad brasilera y británica. Se concluyó que hubo ampliación de la interfase entre la sociología y la salud, a pesar d que existan dificultades antiguas y persistentes con relación a la estructura y foco del sistema de salud, poder en la escuela médica y cultura estudiantil.Starting from a paper about closing the gap between sociology and medicine in Brazil and the United Kingdom that was published in 1971, a historical update was made with the aim of reflecting on the new shapes of health-related teaching and research within the social and human sciences, in these two countries. The methodology was qualitative and the study was developed using secondary data. The reflections were developed through the authors' immersion in Brazilian and British realities. It was concluded

  8. A Generalized Eigensolver based on Smoothed Aggregation (GES-SA) for Initializing Smoothed Aggregation Multigrid (SA)

    Energy Technology Data Exchange (ETDEWEB)

    Brezina, M; Manteuffel, T; McCormick, S; Ruge, J; Sanders, G; Vassilevski, P S

    2007-05-31

    Consider the linear system Ax = b, where A is a large, sparse, real, symmetric, and positive definite matrix and b is a known vector. Solving this system for unknown vector x using a smoothed aggregation multigrid (SA) algorithm requires a characterization of the algebraically smooth error, meaning error that is poorly attenuated by the algorithm's relaxation process. For relaxation processes that are typically used in practice, algebraically smooth error corresponds to the near-nullspace of A. Therefore, having a good approximation to a minimal eigenvector is useful to characterize the algebraically smooth error when forming a linear SA solver. This paper discusses the details of a generalized eigensolver based on smoothed aggregation (GES-SA) that is designed to produce an approximation to a minimal eigenvector of A. GES-SA might be very useful as a standalone eigensolver for applications that desire an approximate minimal eigenvector, but the primary aim here is for GES-SA to produce an initial algebraically smooth component that may be used to either create a black-box SA solver or initiate the adaptive SA ({alpha}SA) process.

  9. 43 Cases Analysis on Women whose Kidney Disease Onset Related to Pregnancy%43例起病与妊娠相关的肾脏病患者的临床分析

    Institute of Scientific and Technical Information of China (English)

    刘玉梅; 鲍宏达; 黄亚娟; 汪年松

    2014-01-01

    目的:了解起病与妊娠相关的肾脏病女性患者的发病率、病因及一般情况。方法:收集2004年8月~2013年1月肾脏科,于妊娠期间及产后6个月内诊断为肾脏病的女性患者,并记录其临床资料。结果:起病与妊娠相关的肾脏病女性的发病率为1.49%(43/2891),53.4%为CKD1~2期患者,6名女性进入终末期肾脏病(0.208%)。67.4%在妊娠期间诊断为肾脏病,大部分因蛋白尿发现(46.5%)。最多的临床诊断为慢性肾小球肾炎(27.9%),最多的病理诊断为IgA肾病(50%)。平均血红蛋白浓度为(105±30)g/L,血钙磷代谢异常比例为20.9%。妊娠至诊断肾脏病的平均时间为(128±288)周(中位数25周),她们的剖宫产比例及死产比例均高于健康妊娠女性(53.8%比16.7%,60%比0%,P<0.05)。43名中的8名女性接受肾脏替代治疗。结论:起病与妊娠相关的肾脏病女性患者的发病率高于文献报道,这些女性的临床及病理诊断与我国慢性肾脏病的流行病学一致,他们贫血及钙磷代谢的控制情况不理想。%Objective:To learn the incidence,causes and general condition of women whose kidney disease onset related to pregnancy. Methods:Women of Han ethnics whose kidney disease onset related to pregnancy were collected from August 2004 to Jan-uary 2013 in nephrology department Inclusive criteria was women diagnosed with kidney disease during pregnancy or within six -month after delivery. Clinical data were recorded. Results:The incidence of women whose kidney disease onset related to pregnancy is 1. 49%(43/2 891). 53. 4% women in chronic kidney disease stage 1 ~2. Six women proceeded to end stage renal disease (0. 208%). Most were discovered during pregnancy(67. 4%),for discovering proteinuria(46. 5%). The most clinical diagnosis was chronic glomerularnephritis(27. 9%). The most pathological diagnosis was IgA nephropathy(50

  10. Evaluación de conocimientos, actitudes, susceptibilidad y autoeficacia frente al VIH/sida en profesionales de la salud Avaliação dos conhecimentos, atitudes, susceptibilidades e auto-eficácia perante o HIV/AIDS nos profissionais da saúde Evaluation of the health professionals' knowledge, attitudes, susceptibilities and self-effectiveness related to HIV/AIDS

    Directory of Open Access Journals (Sweden)

    Ana Fernanda Uribe

    2011-12-01

    Full Text Available Los profesionales de la salud (médicos, psicólogos, trabajadores sociales, enfermeros cumplen un rol de gran importancia en el desarrollo de los programas de salud sexual y reproductiva dirigidos a los adolescentes. Estos profesionales asumen constantemente problemáticas asociadas a la temática, y son quienes buscan reforzar las destrezas de los adolescentes y jóvenes para prevenir conductas de riesgo que atenten contra su salud. Objetivos: evaluar los conocimientos, actitudes, susceptibilidad y autoeficacia frente al VIH/sida en los profesionales, teniendo en cuenta que son los principales agentes de cambio a los que acude la comunidad. Metodología: la muestra se conformó por 34 profesionales de la salud, 70,6% mujeres y 17,6% hombres, con edades entre 19 y 69 años (M = 33,71; DT = 11,53, pertenecientes a una entidad de salud pública de Cali (Colombia. Se les aplicó la "Adaptación colombiana de la escala VIH/sida-65", "Escala multicomponente de fobia al sida" y "Escala de autoeficacia generalizada (SEA-27". Resultados: la mayoría de los profesionales de la salud tienen conocimientos adecuados sobre la infección por VIH, una actitud positiva frente a las personas diagnosticadas con el virus y una mayor autoeficacia frente al VIH/sida. Discusión y conclusiones: aunque los profesionales poseen conocimientos correctos, actitudes positivas y autoeficacia frente a la infección por VIH/sida, es necesario fortalecer estrategias que refuercen algunos conceptos y comportamientos favorables frente al VIH/sida ya que son necesarios para las intervenciones dirigidas a la población que accede a los servicios que prestan los profesionales de salud, con el fin de propiciar actitudes y capacidades en el autocuidado de la comunidad.Os profissionais da saúde (médicos, psicólogos, assistentes sociais, enfermeiros desempenham um papel muito importante no desenvolvimento dos programas de saúde sexual e reprodutiva voltados para a adolesc

  11. Saúde, este obscuro objeto de desejo

    Directory of Open Access Journals (Sweden)

    Fernando Lefèvre

    1997-07-01

    Full Text Available Exploram-se no presente ensaio as relações entre saúde e desejo, envolvendo um dado querer denominado "saúde" e as formas que este querer adquire no contexto do viver contemporâneo. Aponta-se ao final para uma situação radical no que toca à saúde, vítima de um processo irreversível de expansão, que acaba por inviabilizar qualquer tentativa de defini-la, levando a uma perda total de sentido, no contexto de um universo humano tentendo à completa robotização.The present essay explores the relations between health and desire involving a given yearning named "health" and the forms that such feeling acquires in the contemporaneous context of living. It ultimately points to a radical situation in terms of health, victim of a irreversible process of expansion that eventually makes any attempt of definition not viable, leading to a total loss of meaning within a human universe tending to complete robotization.

  12. A proteomic study of rice cultivar TNG67 and its high aroma mutant SA0420.

    Science.gov (United States)

    Lin, Da-Gin; Chou, Szu-Yi; Wang, Arthur Z; Wang, Yi-Wen; Kuo, Shu-Ming; Lai, Chien-Chen; Chen, Liang-Jwu; Wang, Chang-Sheng

    2014-01-01

    Fragrance is a very important economic trait for rice cultivars. To identify the aroma genes in rice, we performed a proteomics analysis of aroma-related proteins between Tainung 67 (TNG67) and its high aroma mutant SA0420. Seventeen of the differentially identified proteins were close related with the aroma phenotype of SA0420. Among them, 9 were found in leaves and 8 were found in grains. One protein (L3) was identified as the chloroplastic glyceraldehyde-3-phosphate dehydrogenase B (OsGAPDHB) which was less abundant in SA0420 than TNG67. Sequence analysis demonstrated that this protein in SA0420 carries a P425S mutation in the C-terminal extension domain, which might hinder the formation of holoenzyme, thereby changing the profile of aroma compounds. The protein profile of OsGAPDHB showed only a weak correlation to its transcription profile. This result indicated that the reduction of OsGAPDHB in SA0420 is regulated by post-translational processes and can only be analyzed by proteomics approach. Transgenic lines suppressing OsGAPDHB through RNAi harbored more fragrance than TNG67 but less than SA0420. With betaine-aldehyde dehydrogenase as the only fragrance gene identified in rice to date, OsGAPDHB may serve as the second protein known to contribute to the aroma phenotype.

  13. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models.

    Science.gov (United States)

    Ono, Yoko; Tanaka, Hirotaka; Takata, Masafumi; Nagahara, Yuki; Noda, Yasuhiro; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Hozumi, Isao; Hara, Hideaki

    2014-01-24

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Recently, it has been reported that a mutation in the sigma-1 receptor causes juvenile ALS. Therefore, the function of the sigma-1 receptor may be important in the pathology of ALS. In the present study, we investigated the effect of SA4503, a sigma-1 receptor agonist, against in in vitro and in vivo ALS models. We first investigated whether SA4503, a sigma-1 receptor agonist, prevented superoxide dismutase 1 (SOD1(G93A))- and serum free-induced cell death of mice motor neuron cells (NSC34) in in vitro model of an ALS. At concentrations of 1-10μM, SA4503 reduced SOD1(G93A)-induced cell death in a concentration-dependent manner, and BD1047, a sigma-1 receptor antagonist, inhibited the protective effect of SA4503. Next, we investigated whether SA4503 affected the phosphorylation levels of Akt (Ser 473) and extracellular signal-regulated kinase (ERK) 1/2 and the expression of the sigma-1 receptor. SA4503 promoted the phosphorylation of Akt (Ser 473) and ERK1/2 in a time-dependent manner, but SA4503 did not affect the expression of the sigma-1 receptor. These results suggest that the protective effect of SA4503 might be involved in promoting the phosphorylation of Akt and ERK1/2. We then investigated whether SA4503 suppressed the progression of ALS in an SOD1(G93A) ALS mouse model. SA4503 did not affect the onset time of ALS. However, it significantly extended the survival time in the SOD1(G93A) mice compared with a vehicle-treated group. These findings indicate that SA4503 is effective in suppressing motor neuron degeneration and symptom progression in ALS.

  14. Atlas mundial da saúde

    OpenAIRE

    Barrozo, Ligia Vizeu

    2009-01-01

    O Atlas é de autoria de Zoé Vaillant, mestre de conferências da Universidade Paris-Ouest-Nanterre-La Défense e membro do laboratório Espaço, Saúde e Territórios e de Gérard Salem, professor de geografia da saúde da Universidade Paris-Ouest-Nanterre-La Défense e coordenador do laboratório Espaço, Saúde e Territórios. Cécile Marin, responsável pela cartografia do Atlas, é geógrafa-cartógrafa, formada pela Universidade d’Orléans. O Atlas mondial de la santé faz parte da série Collection Atlas/M...

  15. Aspectos relacionados à administração e conservação de vacinas em centros de saúde no Nordeste do Brasil Aspects related to vaccine management and preservation in healthcare centers in the Northeastern Brazil

    Directory of Open Access Journals (Sweden)

    Geisy Lanne Muniz Luna

    2011-02-01

    Full Text Available O estudo caracteriza a experiência e atualização do conhecimento sobre imunização da equipe de enfermagem responsável pelas salas de vacinas, descreve as condições de trabalho nesse setor a partir da visão dessa equipe e identifica os procedimentos e atividades diárias realizados por esses profissionais. Trata-se de estudo transversal, realizado em 2007, nas salas de vacinas de 11 Centros de Saúde da Família (CSF em Fortaleza (CE, com a participação de 22 profissionais da equipe de enfermagem. Utilizou check-list e questionário autoaplicável como instrumentos de coleta. Entre as participantes, 44,4% das enfermeiras e 30,8% dos técnicos/auxiliares têm mais de cinco anos de experiência; 55,6% das enfermeiras não possuíam treinamento em vacinas; 88,9% das enfermeiras e 76,9% dos outros profissionais se mantêm atualizados consultando livros, manuais e Internet. Detectaram-se lacunas quanto a estrutura física, verificação e registro do mapa de temperatura e orientações sobre os efeitos pósvacinais na maioria das salas estudadas. O estudo sinaliza que gerenciar o trabalho com imunobiológicos requer conhecimento e treinamento específico para que se possa ofertar serviço de qualidade e que não comprometa a erradicação e o controle de doenças imunopreveníveis.This study characterizes the expertise and updated knowledge on immunization of nursing team responsible for vaccine rooms; it describes the work conditions in that sector from the team's view, and identifies the procedures and daily activities performed by such professionals. This cross-sectional study conducted in 2007 in vaccine rooms of 11 Family Healthcare Centers (CSF in Fortaleza (CE, Brazil, involved 22 nursing team professionals and used a checklist and self-applicable questionnaire as the survey instrument. Among the participants, 44.4% were nurses and 30.8% technicians/assistants have an experience of more than five years; 55.6% of the nurses had

  16. Meta-analysis of factors related to health services that predict treatment default by tuberculosis patients Metanálise de fatores relacionados aos serviços de saúde que predizem o abandono de tratamento por pacientes com tuberculose

    Directory of Open Access Journals (Sweden)

    Pedro Emmanuel Alvarenga Americano do Brasil

    2008-01-01

    Full Text Available The identification of factors that predict tuberculosis (TB treatment default can help control this problem. The current study used a systematic review to investigate associations between TB treatment default and previously studied factors related to health services. Abstracts were searched in the MEDLINE and LILACS databases and in the bibliography of the full texts under evaluation. Studies were included if TB treatment default was evaluated by comparing two or more groups and data could be extracted. A total of 41 studies were included for combining data. It was possible to combine five exposures: "difficult access to health services"; "need for hospitalization"; "training or support for adherence"; "delay in initiating treatment"; "long wait before medical attendance". "Difficult access to health services", "training or support for adherence", and "need for hospitalization" were associated with TB treatment default. All exposures demonstrated heterogeneity, which was only explained in one. Publication bias was only detected for one exposure.Acredita-se que a identificação dos fatores que são preditores do abandono de tratamento de tuberculose contribuiria para o seu controle. Este trabalho combinou, por meio de uma revisão sistemática, medidas de associação entre abandono do tratamento de tuberculose e de fatores relacionados com os serviços de saúde já estudados. Resumos foram procurados nas bases LILACS e MEDLINE e na bibliografia dos textos completos em avaliação. Foram incluídos estudos nos quais foi avaliado o abandono do tratamento através de comparações de dois ou mais grupos e nos quais foi possível a extração de dados. Ao final, 41 investigações foram incluídas para combinação de dados. Foi possível combinar cinco exposições: "difícil acesso aos serviços de saúde"; "necessidade de hospitalização"; "treinamento ou suporte para adesão"; "demora para o início do tratamento" e "espera longa antes da

  17. Response of high-energy particle precipitation to substorm onset

    Science.gov (United States)

    Kellerman, A. C.; Makarevich, R. A.

    2008-12-01

    The process of extra-terrestrial radiowave absorption by ionospheric electrons is known as cosmic noise absorption (CNA) and is routinely detected by ground-based relative opacity meters or riometers, which are sensitive to high-energy particle precipitation (>10 keV). In this study, we investigate the response of high- energy particle precipitation to substorm onset by employing a 7×7-beam imaging riometer system in Northern Scandinavia, IRIS, and the substorm onset database from the IMAGE satellite. The CNA response is investigated with respect to substorm location relative to IRIS. Instantaneous responses are mostly observed when IRIS is located on the same magnetic parallel as the substorm onset region. We investigate dispersionless injections (DIs) associated with substorm onsets as detected by the imaging riometer. It is shown that an auroral absorption signature is present predominantly for DIs located westward of IRIS, which is consistent with high-energy particles propagating eastward from substorm injection location. Superposed epoch analysis of CNA relative to substorm onset timing shows a strong dependence on the azimuthal sector in which the onset is located relative to IRIS. Rapid responses are observed in 90-135 deg geographic azimuths indicating fast westward and poleward propagation from onset location. Responses to onsets located between -90 to -180 deg show a monotonic decrease in rise time. The results are examined in the context of the geosynchronous LANL and GOES satellite data in order to investigate the two propagation mechanisms: expansion of injection region and particle drift.

  18. Respiratory infections precede adult-onset asthma.

    Directory of Open Access Journals (Sweden)

    Aino Rantala

    Full Text Available BACKGROUND: Respiratory infections in early life are associated with an increased risk of developing asthma but there is little evidence on the role of infections for onset of asthma in adults. The objective of this study was to assess the relation of the occurrence of respiratory infections in the past 12 months to adult-onset asthma in a population-based incident case-control study of adults 21-63 years of age. METHODS/PRINCIPAL FINDINGS: We recruited all new clinically diagnosed cases of asthma (n = 521 during a 2.5-year study period and randomly selected controls (n = 932 in a geographically defined area in South Finland. Information on respiratory infections was collected by a self-administered questionnaire. The diagnosis of asthma was based on symptoms and reversible airflow obstruction in lung function measurements. The risk of asthma onset was strongly increased in subjects who had experienced in the preceding 12 months lower respiratory tract infections (including acute bronchitis and pneumonia with an adjusted odds ratio (OR 7.18 (95% confidence interval [CI] 5.16-9.99, or upper respiratory tract infections (including common cold, sinusitis, tonsillitis, and otitis media with an adjusted OR 2.26 (95% CI 1.72-2.97. Individuals with personal atopy and/or parental atopy were more susceptible to the effects of respiratory infections on asthma onset than non-atopic persons. CONCLUSIONS/SIGNIFICANCE: This study provides new evidence that recently experienced respiratory infections are a strong determinant for adult-onset asthma. Reducing such infections might prevent onset of asthma in adulthood, especially in individuals with atopy or hereditary propensity to it.

  19. Anti-rPru p 3 IgE levels are inversely related to the age at onset of peach-induced severe symptoms reported by peach-allergic adults.

    Science.gov (United States)

    Pastorello, Elide Anna; Farioli, Laura; Stafylaraki, Chrysi; Mascheri, Ambra; Scibilia, Joseph; Pravettoni, Valerio; Primavesi, Laura; Piantanida, Marta; Nichelatti, Michele; Asero, Riccardo

    2013-01-01

    Sensitisation to peach lipid transfer protein (LTP; Pru p 3) is significantly associated with severe allergic symptoms in adults, but little is known about the age at onset of peach allergy. We investigated a possible correlation between specific IgE levels to Pru p 3 and the age at onset of peach allergy. One hundred and forty-eight patients allergic to peach were divided into 6 classes according to the age at onset. Sera were analyzed for IgE antibodies to peach, rPru p 3, rPru p 1, rPru p 4, rBet v 1, rBet v 2, total IgE titre, and tryptase; all collected data were statistically analysed. A significant inverse correlation was found between the age at onset of peach allergy and anti-rPru p 3 IgE levels at diagnosis (p age at onset was directly correlated with both anti-rPru p 1 IgE levels (p = 0.0001; Spearman's ρ = 0.3197) and anti-rBet v 1 IgE levels (p = 0.0006; Spearman's ρ = 0.2914) at diagnosis. No correlations were detected between the reported age at onset and anti-peach, anti-rPru p 4, anti-rBet v 2 IgE and total IgE values and serum tryptase levels. At diagnosis, when peach allergy starts at a younger age, it is likely associated with Pru p 3 sensitisation, and the younger the onset, the higher the IgE titres. When peach allergy starts at an older age, it is more likely the result of cross-reactivity to Bet v1.

  20. Assistência em saúde mental sustentada no modelo psicossocial: narrativas de familiares e pessoas com transtorno mental Atención en salud mental basada en el modelo psicosocial: testimonios de familiares y personas con transtorno mental Mental health care based on the psychosocial model: reports of relatives and persons with mental disorders

    Directory of Open Access Journals (Sweden)

    Letícia de Oliveira Borba

    2012-12-01

    Full Text Available Esta pesquisa foi realizada com o método da história oral temática e desenvolvida no ano de 2009, em Curitiba, com oito colaboradores pertencentes a três famílias que tinham um integrante com transtorno mental. O objetivo do estudo foi descrever a percepção de familiares e de portadores de transtorno mental sobre a assistência em saúde mental sustentada no modelo psicossocial. Os dados foram obtidos por meio de entrevista semiestruturada, analisados e apresentados de maneira descritiva. Os colaboradores consideraram os serviços extra-hospitalares, como o Centro de Atenção Psicossocial e os ambulatórios de saúde mental, estratégias inovadoras, e mencionaram o atendimento por equipe multiprofissional, a mediação de conflitos familiares e o princípio de territorialidade. Destacaram o acompanhamento do portador de transtorno mental pela Unidade Básica de Saúde e ressaltaram a importância das associações na rede de saúde mental. Atribuíram à inclusão da família no tratamento a melhora na relação familiar e a aceitação da doença.Investigación según metodología de historia oral temática, desarrollada durante 2009 en Curitiba, con ocho colaboradores pertenecientes a tres familias con un miembro padeciendo transtorno mental. Se objetivó describir la percepción de familiares y portadores de transtorno mental sobre la atención de salud mental basada en el modelo psicosocial. Datos recabados mediante entrevista semiestructurada, analizados y presentados de modo descriptivo. Los colaboradores consideraron estrategias innovadoras a los servicios extrahospitalarios como el Centro de Atención Psicosocial y ambulatorios de salud mental, mencionaron la atención por parte de equipo multidisciplinario, la mediación de conflictos familiares y el principio de territorialidad. Destacaron el seguimiento del portador de transtorno mental por la Unidad Básica de Salud y resaltaron la importancia de las asociaciones en la red de

  1. Permanent education in health. An instrument to enhance interpersonal relations in nursing work La educación permanente en salud. Instrumento potenciador de las relaciones interpersonales del trabajo en enfermería Educação permanente em saúde. Instrumento potencializador das relações interpessoais no trabalho da enfermagem

    Directory of Open Access Journals (Sweden)

    Juliane Portella Ribeiro

    2012-08-01

    Full Text Available This is a reflexive study about the need to adopt Permanent Education in Health, as an instrument capable of transforming interpersonal relations in nursing work, as it values and respect collective construction with a view to the qualification of care. Privileging specialization programs only, with a focus on work techniques, on educative processes, as a training strategy for health services, ends up reinforcing the fragmentation of care, teams and the work process. In conclusion, Permanent Education in Health serves not only as teaching and learning practice to update and transform practices, but also influences team relations, transforming joint action processes and, at the same time, implying each subject-worker involved in health practices.Se trata de un estudio reflexivo sobre la necesidad de adoptar la Educación Permanente en Salud, como un instrumento capaz de transformar las relaciones interpersonales en el trabajo de la enfermería, ya que valora y respeta la construcción colectiva para la calificación de la atención. Privilegiar sólo la especialización con direccionalidad en la técnica del trabajo en los procesos educativos, como estrategia de capacitación para los servicios de salud, acaba por reforzar la fragmentación del cuidado, de los equipos y del proceso de trabajo. Se concluye que la Educación Permanente en Salud, además de servir como práctica de enseñanza y aprendizaje para la actualización y transformación de las prácticas, actúa en las relaciones del equipo, transformando los procesos de acción conjunta y, al mismo tiempo, implicando cada sujeto-trabajador involucrado en las prácticas de salud.Se trata de um estudo reflexivo sobre a necessidade de adotar a Educação Permanente em Saúde, como um instrumento capaz de transformar as relações interpessoais no trabalho da enfermaria, já que, valoriza e respeita a construção coletiva, para a qualificação do atendimento. Privilegiar só a especializa

  2. Biologically inspired robust onset detection

    Science.gov (United States)

    Smith, Leslie S.

    2003-04-01

    Onsets are rapid increases in signal strength. The common onset time in different frequency bands provides an important cue for dynamically grouping sound energy, and hence for sound streaming. Onsets are important for segmenting sounds [Smith, J. New Music Res. 23, 11-23 (1994)] and for determining where to measure IIDs and ITDs for the sound direction finding [Smith, J. Acoust. Soc. Am. 111, 2467 (2002)]. Effective onset detection requires low latency and the capacity to cope with wide variation in the dynamic range. Many neurons in the auditory brainstem are sensitive to onsets. The system filters sound into cochlea-like bands (using a Gammatone filterbank), then spike codes positive-going zero-crossings. A wide dynamic range is achieved by using multiple spike trains per filter band, each with different sensitivity. The spike trains from each band innervate a leaky integrate-and-fire neuron. The excitatory synapses from the spike trains are fast and depressing: the shunting inhibitory synapses are facilitating and slower. The combined effect is that the neuron produces a single spike for each onset over a wide dynamic range with very low latency. The use of both inhibitory and excitatory synapses improves onset detection over purely excitatory synapses, leading to a better sound direction finding than previously reported.

  3. A relação interpessoal entre profissionais de saúde e adolescente gestante: distanciamentos e aproximações de uma prática integral e humanizada Interpersonal relations between health professional and pregnant adolescents: distances and approaches of integral and humanized care

    Directory of Open Access Journals (Sweden)

    Marta Maria Antonieta de Souza Santos

    2012-03-01

    Full Text Available Este estudo apresenta uma análise sobre as relações entre profissionais de saúde e adolescentes gestantes nos espaços do programa de pré-natal de uma maternidade pública do município do Rio de Janeiro. Trata-se de investigação de cunho qualitativo apoiada na vertente interpretativa, tendo como referencial teórico a integralidade e a humanização do cuidado em suas dimensões relacionais. Com base em duas temáticas previamente definidas - interação entre os sujeitos e dimensão educativa das práticas em saúde - foram observados 22 atendimentos individuais e em grupo, com a participação de 31 adolescentes gestantes, 5 profissionais de saúde e 2 estagiárias de nutrição. A interpretação dos dados, orientada pela análise de conteúdo fez emergir cinco categorias. Os resultados apontam a interferência negativa da predominância da dimensão biomédica na percepção dos profissionais de saúde sobre os aspectos psicossocioculturais da gestação na adolescência. Foi observado o não aproveitamento da consulta como espaço privilegiado de construção de significados coletivos e individuais sobre a gestação e a maternidade na adolescência, mas há no contexto estudado profissionais sensibilizados para uma ampliação da visão sobre as necessidades da adolescente gestante.This study presents an analysis of relations between health professionals and pregnant adolescents in the installations of the prenatal care program of a public hospital in Rio de Janeiro. It involves qualitative research based on an interpretive approach, with comprehensiveness and humanization of care in relationship dimensions as a theoretical benchmark. Based on two predefined themes - the interaction between subjects and educational dimension of health practices - 22 individual and group care sessions were observed, with the participation of 31 pregnant adolescents, 5 professionals and 2 nutrition interns. The interpretation of the data using

  4. Urinary incontinence in the puerperium and its impact on the health-related quality of life La incontinencia urinaria en periodo de posparto y su impacto en la calidad de vida relacionada a salud A incontinência urinária no puerpério e o impacto na qualidade de vida relacionada à saúde

    Directory of Open Access Journals (Sweden)

    Lígia da Silva Leroy

    2012-04-01

    Full Text Available This case-control study evaluated whether UI in the puerperium compromises the health-related quality of life (HRQoL and if so, in which aspects. The study included 344 women (77 case group and 267 control group up to 90 days postpartum, who were attended the Obstetrics Outpatient Clinic of a public teaching hospital, for the postpartum follow up consultation. A socio-demographic and clinical data questionnaire formulated and validated for the study, the International Consultation on Incontinence Questionnaire - Short-Form (ICIQ-SF, the King's Health Questionnaire (KHQ and the Medical Outcomes Study 36 - Item Short Form Health Survey (SF-36, were applied. The mean score of the ICIQ-SF was 13.9 (SD: 3.7. The case group presented high mean scores in the domains Impact of the Incontinence, Emotions, Daily Activity Limitations and Physical Limitations, of the KHQ. The groups differed significantly in the domains Physical Aspects, Pain, General Health Status, Vitality, Social Aspects and Mental Health of the SF-36. It is concluded that UI significantly affects the physical and mental health of puerperae.Estudio caso-controle ha evaluado se la incontinencia urinaria posparto afecta la calidad de vida relacionada a salud y en que aspectos. Serán incluidas 344 mujeres (77 casos y 267 controles hasta 90 días posparto que asistieron a la Clínica de Obstetricia de un hospital de público y de enseñanza. Fue aplicado cuestionario formulado y validado, el "International Consultation on Incontinence Questionnaire - Short -Form" (ICIQ-SF, "King´s Health Questionnaire" (KHQ y "Medical Outcomes Study 36 - Item Short Form Health Survey" (SF-36. La media del ICIQ-SF fue 13,9 (DP: 3,7. Casos tenían altos puntajes en los dominios del Impacto de la Incontinencia, Emociones, Limitaciones de las Actividades Diarias y Limitaciones Físicas del KHQ. Los grupos presentaron diferencias significativamente en los dominios Aspectos Físicos, Dolor, Estado General de la

  5. Studies of the aggregation of RNase Sa

    DEFF Research Database (Denmark)

    Khasa, Harshit; Kramer, Ryan; Maddux, Nathan

    2014-01-01

    Thirty-eight mutants of RNase Sa (ribonuclease from Streptomyces aureofaciens) were examined for their structure, thermal sensitivity, and tendency to aggregate. Although a biphasic correlation was seen between the effect of temperature on structure and the free energy of transfer changes in many...

  6. Relações de saúde e trabalho em assentamento rural do MST na região de fronteira Brasil-Paraguai Health and work relations in a rural settlement of the MST in the Brazil-Paraguay border region

    Directory of Open Access Journals (Sweden)

    Eduardo Espíndola Fontoura Júnior

    2011-11-01

    Full Text Available Com o presente artigo, busca-se relatar e analisar as relações entre saúde e trabalho de pequenos produtores rurais do Movimento dos Trabalhadores Rurais Sem Terra (MST. Quanto à metodologia, adotou-se o aporte da investigação participativa e as bases da educação popular. O estudo realizado tornou possível uma compreensão de saúde e de trabalho mediante as narrativas dos trabalhadores e histórias relativas às lutas coletivas contra a exclusão e a violência no campo. Constataram-se importantes aspectos próprios a esse grupo populacional, como o sentido de conquista da propriedade da terra, os conflitos advindos da 'militância' e as diferenças de gênero e geração. Com base nos relatos, analisaram-se também os acidentes e os riscos relacionados à atividade de trabalho no assentamento rural, principalmente a exposição ao agrotóxico. Confirmaram-se, ainda, a solidariedade e a cooperação como valores importantes e como base de novas relações, um modo distinto de organização social coletiva do trabalho.In this article, we aim to report on and analyze the relationship between health and work of small farmers of the Landless Workers Movement (MST. So far as the methodology is concerned, we used participatory research and the basics of popular education. The study allowed for an understanding of health and work based on the workers' narratives, stories relating to collective struggles against exclusion and violence in the countryside. Important aspects related to this population group as were discovered, such as, for example, the sense of conquest of land ownership, the conflicts arising from 'activism,' and the differences of gender and generations. From the reports that were provided, we also examined the accidents and risks related to work in the rural settlement, particularly exposure to pesticides. It was also found that solidarity and cooperation are important values, basic elements for new relations and a distinctive

  7. Commercial statistical bulletin of the Brazilian electric utility Centrais Eletricas de Santa Catarina S.A; Boletim estatistico comercial da CELESC: Centrais Eletricas de Santa Catarina S.A

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    Statistical data concerning the Brazilian Centrais Eletricas de Santa Catarina S.A. utility relative to April 1996 are presented. They include, among other things, electricity consumption, number and class of consumers and electricity rates 6 figs., 50 tabs.

  8. Study on the related factors of occurrence of vulvar dystrophy in women at peak onset age%高峰发病年龄女性外阴营养不良发生的相关因素研究

    Institute of Scientific and Technical Information of China (English)

    吴晓丽; 申艳

    2011-01-01

    Objective: To study the related factors of occurrence of vulvar dystrophy in women at peak onset age. Methods: 87 patients aged 40 ~ 60 years old who were diagnosed as vulvar dystrophy by pathological examination and biopsy were selected as case group, 98 patients without vulvar dystrophy were selected as control group, the relationship between the occurrence of vulvar dystrophy and the factors including working and living circumstances, dietary habits, health habits, diseases, the history of menstruation and childbearing history was analyzed. Results: The risk factors of vulvar dystrophy included allergic constitution, favoring salty, hot and thermal foods, sedentariness, washing underwears by washing powder and vaginitis (OR > 1) , the protective factors of vulvar dystrophy included extravert personality, favoring vegetarian diet and pork liver (OR < 1) . Conclusion: Allergic constitution, incorrect dietary habits and recurrent vaginitis are related to female vulvar dystrophy closely.%目的:研究高峰发病年龄女性外阴营养不良发生的相关危险因素.方法:以40~60岁之间经病理活检确诊的外阴营养不良患者87例作为病例组,以非外阴营养不良患者98例为对照组,分析外阴营养不良的发生与工作生活环境、饮食习惯、卫生习惯、疾病情况、妇女月经史及生育史等因素之间关系.结果:过敏体质、饮食习惯中偏咸辣烫、生活习惯中喜久坐、洗衣粉洗涤内裤及白带色黄等可能是外阴营养不良发生的危险因素(OR>1),而个性开朗、饮食偏素和喜食猪肝等可能是外阴营养不良的保护性因素(OR<1).结论:过敏体质、不合理饮食习惯、卫生生活习惯及反复阴道炎等与女性外阴营养不良的发生关系较大.

  9. Adult onset pityriasis rubra pilaris

    Directory of Open Access Journals (Sweden)

    Sehgal Virendra

    2008-01-01

    Full Text Available Pityriasis rubra pilaris (PRP has always been an intriguing topic ever since its inception. It is a group of chronic disorders characterized by reddish orange plaques with pityriasiform scaling showing follicular keratoses, palmoplantar keratoderma, and sometimes, erythroderma. It occurs all over the world but with racial variations. Its incidence might vary and the age at onset, behavior, clinical appearance, and prognosis are considered to be very important for its classification. It may manifest either as Type I classical adult onset PRP, Type II atypical adult (onset PRP, or Type VI PRP (HIV-associated PRP pityriasis rubra pilaris in contrast to classical juvenile (Type III and circumscribed juvenile (Type IV encountered among children. Its diagnosis is largely clinical with microscopic pathology being a useful supplement, but it continues to be a therapeutic dilemma. We review the epidemiology of adult onset PRP here and take stock of the prevalent treatment options.

  10. Excesso de peso e qualidade de vida relacionada à saúde em adolescentes de Florianópolis, SC Exceso de peso y calidad de vida relacionada con la salud en adolescentes de Florianópolis, Sur de Brasil Overweight and health-related quality of life in adolescents of Florianópolis, Southern Brazil

    Directory of Open Access Journals (Sweden)

    Nádia Kunkel

    2009-04-01

    Full Text Available OBJETIVO: Avaliar a qualidade de vida relacionada à saúde de adolescentes e sua associação com o excesso de peso. MÉTODOS: Estudo transversal com 467 adolescentes de 15 a 18 anos de idade de uma escola pública de Florianópolis, SC, e de seus respectivos pais, realizado em 2007. Sobrepeso e obesidade foram definidos pelo índice de massa corporal. A combinação de sobrepeso e obesidade foi considerada como excesso de peso. A qualidade de vida relacionada à saúde foi avaliada por meio do questionário sobre qualidade de vida pediátrica PedsQL 4.0, versões adolescente e pais. Análises dos dados incluíram estatística descritiva e regressão logística com estimação de razões de chances brutas e ajustadas. RESULTADOS: A taxa de resposta entre adolescentes foi de 99,4% e entre os pais 53,4%. As prevalências de sobrepeso e obesidade foram de 12,2% e 3,6%, respectivamente. O grupo com excesso de peso obteve menores escores de qualidade de vida que o grupo sem excesso de peso, exceto para o domínio emocional nos adolescentes e na saúde psicossocial para os pais. Após o ajuste, a chance de um adolescente com excesso de peso ter baixa qualidade de vida foi 3,54 vezes (IC 95% 1,94;6,47 maior que um adolescente sem excesso de peso. Adolescentes do sexo feminino apresentaram escores mais baixos de qualidade de vida. CONCLUSÕES: A qualidade de vida relacionada à saúde foi significativamente mais baixa em adolescentes com excesso de peso. Medidas dirigidas ao controle de peso na população adolescente e instrumentos de avaliação de qualidade de vida constituem-se importantes aliados para um melhor e mais completo entendimento deste importante problema de saúde pública.OBJETIVO: Evaluar la calidad de vida relacionada con la salud de adolescentes y su asociación con exceso de peso. MÉTODOS: Estudio transversal con 467 adolescentes de 15 a 18 años de edad de una escuela pública de Florianópolis, Sur de Brasil, y de sus

  11. Multiple application delayed onset contact urticaria

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Maibach, H I

    1984-01-01

    An unusual type of contact urticaria to formalin is described, based on 4 patients and experiments in 14 volunteers. The contact urticaria appeared on healthy skin only following repeated open applications or after a single application on slightly diseased skin. The possible relation...... of this phenomenon for patients claiming textile intolerance is discussed. Further tests are required to reveal the mechanism of this delayed onset contact urticaria to formalin....

  12. Relatório de estágio [no Laboratório de análises clínicas Dr. Joaquim Chaves e na Genomed - Diagnósticos de Medicina Molecular SA

    OpenAIRE

    Santos, Joana Nery

    2015-01-01

    Relatório de estágio de mestrado, Análises Clínicas, Universidade de Lisboa, Faculdade de Farmácia, 2015 O presente relatório de estágio é decomposto em duas partes e pretende discutir as atividades realizadas durante o estágio curricular do Mestrado em Análises Clínicas da Faculdade de Farmácia da Universidade de Lisboa. A primeira parte aborda resumidamente questões relacionadas com a atividade de estágio, nas áreas de Química e Hematologia Clínicas, realizado no Laboratório de Análises ...

  13. Oncologia de Cabeça e Pescoço: enquadramento epidemiológico e clínico na avaliação da Qualidade de Vida Relacionada com a Saúde Head and Neck Cancer: Health Related Quality of Life Assessment considering clinical and epidemiological perspectives

    Directory of Open Access Journals (Sweden)

    Augusta Silveira

    2012-03-01

    Full Text Available A importância das doenças oncológicas como causa de morbilidade e mortalidade está em crescimento, sendo reconhecido o seu impacto social e peso global pelos custos económicos e sociais envolvidos na sua prevenção, tratamento e reabilitação. As patologias oncológicas de cabeça e pescoço representam um dos seis tumores malignos mais prevalentes em todo o mundo, com um valor estimado de 900.000 novos casos diagnosticados anualmente em escala mundial. Estes doentes oncológicos apresentam deterioração de funções básicas que, quando percepcionadas, têm impacto negativo na sua Qualidade de Vida. Um registo oncológico adequado permite uma análise mais rigorosa dos resultados obtidos na avaliação da Qualidade de Vida Relacionada com a Saúde. Este estudo incluiu 380 doentes oncológicos de cabeça e pescoço e demonstra que as mulheres apresentam resultados de Qualidade de Vida globalmente inferiores. Salienta-se ainda a importância do diagnóstico precoce em oncologia, que se relaciona frequentemente com melhores scores e conclui-se que a localização do tumor tem impacto sobre a autopercepção de Qualidade de Vida. Os valores de Qualidade de Vida Relacionada com a Saúde devem ser interpretados à luz das variáveis sociodemográficas e clínicas, para melhor se avaliar a Patologia Oncológica de Cabeça e Pescoço numa perspectiva epidemiológica no sentido de melhor compreender o processo saúde - doença.The importance of oncology diseases as a cause of morbidity and mortality is increasing worldwide, and their social impact is being recognized due to economic and social costs involved in prevention, treatment and rehabilitation. Head and neck cancer is one of the six most prevalent neoplasms worldwide, with an estimated 900,000 new cases diagnosed annually. Regardless of tumor site, deterioration of basic functions affecting head and neck areas are perceived and affect patients' lives. Appropriate cancer registration may

  14. Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures

    NARCIS (Netherlands)

    Koch, Marcus W.; Polman, Susanne K. L.

    2009-01-01

    Background Partial onset seizures are often treated with the standard antiepileptic drug carbamazepine. Oxcarbazepine is a newer antiepileptic drug related to carbamazepine that is claimed to be better tolerated. Objectives To compare efficacy and tolerability of carbamazepine and oxcarbazepine mono

  15. Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures

    NARCIS (Netherlands)

    Koch, Marcus W.; Polman, Susanne K. L.

    2009-01-01

    Background Partial onset seizures are often treated with the standard antiepileptic drug carbamazepine. Oxcarbazepine is a newer antiepileptic drug related to carbamazepine that is claimed to be better tolerated. Objectives To compare efficacy and tolerability of carbamazepine and oxcarbazepine mono

  16. Late-Onset Rash Associated with Lamotrigine: Case Report

    Directory of Open Access Journals (Sweden)

    Raquel Ribeiro

    2014-10-01

    Full Text Available The use of lamotrigine in Bipolar Disorder has been approved by the F.D.A since 2003. Rash is the more frequent adverse effect related to the treatment with Lamotrigine and in several cases is the cause for discontinuation of medical treatment. The less frequent related cases of rash are the late onset ones. About a women’s case with a late onset of rash, we revised the clinical use of Lamotrigine in Bipolar Disorder published bibliography which is followed by a special focus in the rash itself and finally we present some particular issues about late onset rash.

  17. SAPS onset timing during substorms and the westward traveling surge

    Science.gov (United States)

    Mishin, Evgeny, V.

    2016-07-01

    We present multispacecraft observations in the magnetosphere and conjugate ionosphere of the onset time of subauroral polarization streams (SAPS) and tens of keV ring current injections on the duskside in three individual substorms. This is probably the first unequivocal determination of the substorm SAPS onset timing. The time lag between the SAPS and substorm onsets is much shorter than the gradient-curvature drift time of ˜10 keV ions in the plasmasphere. It seemingly depends on the propagation time of substorm-injected plasma from the dipolarization onset region to the plasmasphere, as well as on the SAPS position. These observations suggest that fast onset SAPS and ring current injections are causally related to the two-loop system of the westward traveling surge.

  18. Trabalho em turnos: estado geral de saúde relacionado ao sono em trabalhadores de enfermagem Trabajo por turnos: estado general de salud relacionado al sueño de trabajadores de enfermería Shift work: overall health state related to sleep in nursing workers

    Directory of Open Access Journals (Sweden)

    Sandra Soares Mendes

    2012-12-01

    Full Text Available O objetivo deste estudo foi identificar os sintomas referentes ao estado geral de saúde associado ao trabalho em turnos de enfermagem e relacioná-los com a qualidade do sono. O estudo foi realizado no Hospital da Irmandade da Santa Casa de Poços de Caldas, Minas Gerais. Participaram 136 profissionais de enfermagem, com média de idade de 33,1 anos, divididos nas seguintes categorias: enfermeiro (8,1%; técnico de enfermagem (80,9%; auxiliar de enfermagem dos turnos diurno e noturno (11%. Os sintomas de saúde foram identificados a partir do Inventário de Estado Geral de Saúde, e a qualidade do sono foi avaliada pelo Diário do Sono. Os dados foram estatisticamente significativos pelo Teste Qui-Quadrado (p=0,021 para a presença do sintoma de flatulência ou distensão abdominal no turno noturno. Constatou-se com a análise de regressão linear múltipla que os sujeitos do turno diurno que apresentaram os sintomas de má digestão (às vezes ou sempre e irritabilidade (sempre tiveram pior qualidade de sono noturno.Se objetivó identificar síntomas referentes al estado general de salud asociado al trabajo por turnos de enfermería y relacionarlos con la calidad del sueño. Realizado en Hospital de la Hermandad de Santa Casa de Poços de Caldas, estado de Minas Gerais. Participaron (n=136 profesionales de enfermería, con media etaria de 33,1 años, divididos en las categorías: enfermero 8,1%, técnico de enfermería 80,9%, auxiliar de enfermería 11,0% de turnos diurno y nocturno. Los síntomas de salud se identificaron mediante Inventario General de Salud y la calidad de sueño se evaluó por Diario del Sueño. Datos estadísticamente significativos según test Chi-Cuadrado (p=0,021 para presencia del síntoma de flatulencia o distensión abdominal en turno nocturno. Mediante análisis de regresión lineal múltiple, los sujetos del turno diurno que presentaban síntomas de mala digestión (eventualmente o siempre e irritabilidad (siempre

  19. Does Salicylic Acid (SA) Improve Tolerance to Salt Stress in Plants? A Study of SA Effects On Tomato Plant Growth, Water Dynamics, Photosynthesis, and Biochemical Parameters.

    Science.gov (United States)

    Mimouni, Hajer; Wasti, Salma; Manaa, Arafet; Gharbi, Emna; Chalh, Abdellah; Vandoorne, Bertrand; Lutts, Stanley; Ben Ahmed, Hela

    2016-03-01

    Environmental stresses such as salinity directly impact crop growth, and by extension, world food supply and societal prosperity. It is estimated that over 800 million hectares of land throughout the world are salt-affected. In arid and semi-arid regions, salt concentration can be close to that in the seawater. Hence, there are intensive efforts to improve plant tolerance to salinity and other environmental stressors. Salicylic acid (SA) is an important signal molecule for modulating plant responses to stress. In the present study, we examined, on multiple plant growth related endpoints, whether SA applied through the rooting medium could mitigate the adverse effects of salinity on tomato (Solanum lycopersicum) cv. Marmande. The latter is a hitherto understudied tomato plant from the above perspective; it is a classic variety that produces the large ribbed tomatoes in the Mediterranean and consumed worldwide. We found salt stress negatively affected the growth of cv. Marmande tomato plants. However, the SA-treated plants had greater shoot and root dry mass, leaf area compared to untreated plants when exposed to salt stress. Application of SA restores photosynthetic rates and photosynthetic pigment levels under salt (NaCl) exposure. Leaf water, osmotic potential, stomatal conductance transpiration rate, and biochemical parameters were also ameliorated in SA-treated plants under saline stress conditions. Overall, these data illustrate that SA increases cv. Marmande tomato growth by improving photosynthesis, regulation and balance of osmotic potential, induction of compatible osmolyte metabolism, and alleviating membrane damage. We suggest salicylic acid might be considered as a potential growth regulator to improve tomato plant salinity stress resistance, in the current era of global climate change.

  20. Health-related quality of life and working conditions among nursing providers Calidad de vida asociada a la salud y condiciones de trabajo entre profesionales de enfermería Qualidade de vida associada a saúde e condições de trabalho entre profissionais de enfermagem

    Directory of Open Access Journals (Sweden)

    Amanda Aparecida Silva

    2010-08-01

    Full Text Available OBJECTIVE: To evaluate working conditions associated with health-related quality of life (HRQL among nursing providers. METHODS: Cross-sectional study conducted in a university hospital in the city of São Paulo, Southeastern Brazil, during 2004-2005. The study sample comprised 696 registered nurses, nurse technicians and nurse assistants, predominantly females (87.8%, who worked day and/or night shifts. Data on sociodemographic information, working and living conditions, lifestyles, and health symptoms were collected using self-administered questionnaires. The following questionnaires were also used: Job Stress Scale, Effort-Reward Imbalance (ERI and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36. Ordinal logistic regression analysis using proportional odds model was performed to evaluate each dimension of the SF-36. RESULTS: Around 22% of the sample was found to be have high strain and 8% showed an effort-reward imbalance at work. The dimensions with the lowest mean scores in the SF-36 were vitality, bodily pain and mental health. High-strain job, effort-reward imbalance (ERI>1.01, and being a registered nurse were independently associated with low scores on the role emotional dimension. Those dimensions associated to mental health were the ones most affected by psychosocial factors at work. CONCLUSIONS: Effort-reward imbalance was more associated with health than high-strain (high demand and low control. The study results suggest that the joint analysis of psychosocial factors at work such as effort-reward imbalance and demand-control can provide more insight to the discussion of professional roles, working conditions and HRQL of nursing providers.OBJETIVO: Evaluar condiciones de trabajo asociadas a la calidad de vida relacionada con la salud entre profesionales de enfermería. MÉTODOS: Estudio transversal realizado en un hospital universitario de Sao Paulo, Sureste de Brasil, en 2004-2005. La población estudiada fue de 696

  1. 什么是SA8000

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    20世纪末期,欧洲、美国和澳大利亚都先后出现了一些关于“企业社会责任”的多边组织,并逐步形成了一些评价体系和认证制度。SA8000(SOCIAL ACCOUT ABILTY8000的英文简称)是其中最有名的标准之

  2. DAYA SAING KAKAO INDONESIA DI PASAR INTERNASIONAL

    Directory of Open Access Journals (Sweden)

    Anggita Tresliyana

    2015-07-01

    Full Text Available Cocoa is one of the major Indonesian agricultural export products. Cocoa international market has great potential regarding world’s consumption growth, therefore Indonesia is expected to take advantage on existing opportunities. The aims of this study were to analyze the competitiveness of Indonesian cocoa beans and processed cocoa trade in the international market as well as the level of competition between cocoa exporting countries. By using Revealed Comparative Advantage (RCA and Spearman Rank Correlation, it showed that Indonesia had a comparative advantage as an cocoa exporter on the international market, the highest for cocoa beans and the lowest for cocoa paste; Indonesia also had a significant correlation to exporting countries in cocoa beans’ market (Ghana and cocoa paste’s market (Netherlands and Malaysia, the correlation suggests that there were high correlation between Indonesia and the exporting country in competing for market share.Keywords: cocoa, comparative advantage, international trade, competitiveness, market share, RCA ABSTRAKKakao merupakan salah satu komoditas pertanian unggulan ekspor Indonesia.  Pasar kakao memiliki potensi yang besar dilihat dari peningkatan konsumsi dunia, sehingga Indonesia diharapkan dapat memanfaatkan peluang yang ada.  Tujuan penelitian ini adalah menganalisis daya saing perdagangan biji kakao dan kakao olahan Indonesia di pasar internasional serta hubungan daya saing antar negara eksportir kakao. Dengan menggunakan Reavealed Comparative Advantage (RCA, dan Korelasi Rank Spearman, hasil analisis menunjukkan bahwa Indonesia memiliki keunggulan komparatif sebagai eksportir biji kakao dan kakao olahan di pasar internasional, tertinggi untuk biji kakao dan terendah untuk kakao pasta;  Indonesia juga memiliki korelasi yang signifikan di beberapa negara untuk pasar biji kakao (Ghana dan kakao pasta (Belanda dan Malaysia, korelasi tersebut menunjukkan bahwa terdapat hubungan daya saing yang cukup

  3. Atmospheric environment for ASTP (SA-210) launch

    Science.gov (United States)

    Johnson, D. L.

    1976-01-01

    A summary is presented of selected atmospheric conditions observed near ASTP/SA-210 launch time on July 15, 1975, at Kennedy Space Center, Florida. Values of ambient pressure, temperature, moisture, ground winds, visual observations (cloud), density, index of refraction, and wind/wind shear aloft are included. A final meteorological data tape for the ASTP launch, consisting of wind and thermodynamic parameters versus altitude, has been constructed.

  4. IkusaSA. Integrated Assessment for Sustainability

    CSIR Research Space (South Africa)

    Scholes, RJ

    2012-10-01

    Full Text Available , have intended and unintended consequences across a range of important issues. The IkusaSA model system comprises: ? A South African national IAM nested within one or more ?state-of-the-art? global IAMs that predict trade, climate change and human.... The desired outcome is a well-functioning interface between sectors and between technical assessments and policy action. WHAT IS AN INTEGRATED ASSESSMENT MODEL (IAM)? An IAM is a numerical simulation of the dynamic interaction between socio...

  5. Solar wind control of the local time of substorm onset

    Science.gov (United States)

    Grocott, Adrian; Case, Nathan; Laundal, Karl; Laurens, Hannah; Milan, Steve

    2017-04-01

    We use solar wind and interplanetary magnetic field data, along with satellite global auroral imagery, to investigate what controls the magnetic local time (MLT) of substorm onset. We find that substorm onsets occur over a wide range of MLTs (18 - 4 hrs), with a typical MLT (mode) of 23 hrs. In agreement with previous studies, IMF BY , acts to move the onset to an earlier/later local time in the northern hemisphere and a later/earlier local time in the southern hemisphere, depending on the sign of BY , consistent with a twist of the conjugate magnetic field line. This effect explains a small fraction of the observed MLT variation (˜ 1 hr), but cannot account for the tendency of onset to be often displaced to earlier ( 23 hrs) MLTs in both hemispheres. We also inspect the relationship between solar wind V Y and onset MLT, which also has a small, but measurable effect on the local time of substorm onset. This effect acts in the same sense in the northern and southern hemispheres, moving onset to earlier times for positive V Y and later times for negative V Y . We find that a function relating both BY and V Y to onset MLT produces a better fit than a function based on either parameter alone.

  6. Climate indices, rainfall onset and retreat, and malaria in Nigeri

    Directory of Open Access Journals (Sweden)

    A.J. Thomso

    2010-12-01

    Full Text Available Background & objectives: Rainfall in western sub-Saharan Africa is related to seasonal shifts ofthe Inter-tropical Convergence Zone, which moves northward early in the year, retreating in thesecond half of the year. The objective of the present study was to determine significant relationshipsbetween onset and retreat timing and climate indices. The relationship between timing and malariacase reporting was then evaluated.Methods: Relationships between published rainfall onset and retreat dates for Nigeria from 1971–2000 were evaluated in relation to pairs of climate indices using response surface analysis. Graphicalrepresentation of the response surface in relation to the underlying data was used to identify instancesof overfitting. Association of onset and retreat timing with published case reporting records wasevaluated using graphical and correlation analysis.Results: Onset timing and rate of advance were related to ENSO (El Niño-Southern Oscillation,in combination with the Northern Annular Mode (NAM, while retreat timing was related to NAO(North Atlantic Oscillation, in combination with the East Pacific (EP or West Pacific (WPindex, depending on location. Later onset was associated with faster northward progression ofonset. Retreat date at Kano, the most northerly of the study locations, increased over the period1990–2000, with higher case reporting for Nigeria as a whole being associated with the last threeyears of that period.Interpretation & conclusion: Rainfall retreat occurs much faster than onset, with onset and retreattiming and rate of onset advance being related to combinations of climate indices rather than to asingle index. Threshold for determining a “rainy” day would influence results. The increase innational case reporting with delayed retreat at Kano may be related to the extension of the shorttransmission period in the north.

  7. Phase analysis method for burst onset prediction

    Science.gov (United States)

    Stellino, Flavio; Mazzoni, Alberto; Storace, Marco

    2017-02-01

    The response of bursting neurons to fluctuating inputs is usually hard to predict, due to their strong nonlinearity. For the same reason, decoding the injected stimulus from the activity of a bursting neuron is generally difficult. In this paper we propose a method describing (for neuron models) a mechanism of phase coding relating the burst onsets with the phase profile of the input current. This relation suggests that burst onset may provide a way for postsynaptic neurons to track the input phase. Moreover, we define a method of phase decoding to solve the inverse problem and estimate the likelihood of burst onset given the input state. Both methods are presented here in a unified framework, describing a complete coding-decoding procedure. This procedure is tested by using different neuron models, stimulated with different inputs (stochastic, sinusoidal, up, and down states). The results obtained show the efficacy and broad range of application of the proposed methods. Possible applications range from the study of sensory information processing, in which phase-of-firing codes are known to play a crucial role, to clinical applications such as deep brain stimulation, helping to design stimuli in order to trigger or prevent neural bursting.

  8. Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey.

    Science.gov (United States)

    Silove, Derrick; Alonso, Jordi; Bromet, Evelyn; Gruber, Mike; Sampson, Nancy; Scott, Kate; Andrade, Laura; Benjet, Corina; Caldas de Almeida, Jose Miguel; De Girolamo, Giovanni; de Jonge, Peter; Demyttenaere, Koen; Fiestas, Fabian; Florescu, Silvia; Gureje, Oye; He, Yanling; Karam, Elie; Lepine, Jean-Pierre; Murphy, Sam; Villa-Posada, Jose; Zarkov, Zahari; Kessler, Ronald C

    2015-07-01

    The age-at-onset criterion for separation anxiety disorder was removed in DSM-5, making it timely to examine the epidemiology of separation anxiety disorder as a disorder with onsets spanning the life course, using cross-country data. The sample included 38,993 adults in 18 countries in the World Health Organization (WHO) World Mental Health Surveys. The WHO Composite International Diagnostic Interview was used to assess a range of DSM-IV disorders that included an expanded definition of separation anxiety disorder allowing onsets in adulthood. Analyses focused on prevalence, age at onset, comorbidity, predictors of onset and persistence, and separation anxiety-related role impairment. Lifetime separation anxiety disorder prevalence averaged 4.8% across countries (interquartile range [25th-75th percentiles]=1.4%-6.4%), with 43.1% of lifetime onsets occurring after age 18. Significant time-lagged associations were found between earlier separation anxiety disorder and subsequent onset of internalizing and externalizing DSM-IV disorders and conversely between these disorders and subsequent onset of separation anxiety disorder. Other consistently significant predictors of lifetime separation anxiety disorder included female gender, retrospectively reported childhood adversities, and lifetime traumatic events. These predictors were largely comparable for separation anxiety disorder onsets in childhood, adolescence, and adulthood and across country income groups. Twelve-month separation anxiety disorder prevalence was considerably lower than lifetime prevalence (1.0% of the total sample; interquartile range=0.2%-1.2%). Severe separation anxiety-related 12-month role impairment was significantly more common in the presence (42.4%) than absence (18.3%) of 12-month comorbidity. Separation anxiety disorder is a common and highly comorbid disorder that can have onset across the lifespan. Childhood adversity and lifetime trauma are important antecedents, and adverse effects on

  9. Controle social na saúde: discutindo os resultados de uma pesquisa com enfermeiras Control social en salud: discutiendo los resultados de una investigación con enfermeras Health-related social control study: discussion of the findings with registered nurses

    Directory of Open Access Journals (Sweden)

    Cássia Irene Spinelli Arantes

    2009-01-01

    Full Text Available Objetivou-se, neste trabalho, relatar a experiência de um processo de discussão dos resultados de uma pesquisa sobre controle social na atenção básica à saúde. Descreve-se o processo de planejamento, desenvolvimento e avaliação de dois encontros educativos participativos realizados com 12 enfermeiras. Apresentam-se as expectativas e a avaliação das participantes; suas reflexões sobre os resultados da pesquisa; e a re-elaboração das ações de fortalecimento do controle social na saúde. Foram apontadas novas possibilidades de atuação na área e os diferentes responsáveis pela sua execução. Foram relatadas ações de responsabilidade do profissional de enfermagem, evidenciando a existência de um papel no âmbito do controle social a ser desempenhado pelo enfermeiro na atenção básica à saúde.En este estudio se tuvo como objetivo, relatar la experiencia de un proceso de discusión de los resultados de una investigación sobre control social en la atención básica de salud. Se describe el proceso de planificación, desarrollo y evaluación de dos encuentros educativos participativos realizados con 12 enfermeras. Se presentan las expectativas y la evaluación de las participantes; sus reflexiones sobre los resultados de la investigación; y la reelaboración de las acciones de fortalecimiento del control social en la salud. Fueron señaladas nuevas posibilidades de actuación en el área y los diferentes responsables por su ejecución. Así mismo se relataron acciones de responsabilidad del profesional de enfermería, evidenciando la existencia de un papel en el ámbito del control social a ser desempeñado por el enfermero en la atención básica de salud.The objective of this study was to discuss the findings of a study on social control in primary care services with registered nurses. The planning, development, and evaluation of two educational meetings with 12 registered nurses are described. Participants' expectations

  10. Adult-onset food allergy.

    Science.gov (United States)

    Kivity, Shmuel

    2012-01-01

    The prevalence of food allergy is increasing in both the pediatric and adult populations. While symptom onset occurs mostly during childhood, there are a considerable number of patients whose symptoms first begin to appear after the age of 18 years. The majority of patients with adult-onset food allergy suffer from the pollen-plant allergy syndromes. Many of them manifest their allergy after exercise and consuming food to which they are allergic. Eosinophilic esophagitis, an eosinophilic inflammation of the esophagus affecting individuals of all ages, recently emerged as another allergic manifestation, with both immediate and late response to the ingested food. This review provides a condensed update of the current data in the literature on adult-onset allergy.

  11. Is an onset vortex important for monsoon onset over Kerala?

    Digital Repository Service at National Institute of Oceanography (India)

    RameshKumar, M.R.; Sankar, S.; Reason, C.

    Inter-annual variability in the formation of the mini warm pool [sea-surface temperature (SST) more than 30 degrees C] over the south eastern Arabian Sea (SEAS) and its role in the formation of the monsoon onset vortex (MOV) has been examined using...

  12. Slow saccades in bulbar-onset motor neurone disease.

    Science.gov (United States)

    Donaghy, Colette; Pinnock, Ralph; Abrahams, Sharon; Cardwell, Chris; Hardiman, Orla; Patterson, Victor; McGivern, R Canice; Gibson, J Mark

    2010-07-01

    Historical studies of eye movements in motor neurone disease (MND) have been conflicting although current findings suggest that eye movement abnormalities relate to frontal lobe impairment. Numerous case reports, however, describe slow saccades and supranuclear gaze palsies in patients with MND often associated with bulbar-onset disease. We performed a study of saccades and smooth pursuit in a large group of patients with MND to examine for any differences between bulbar-onset and spinal-onset patients. Forty-four patients (14 bulbar-onset and 30 spinal-onset patients) and 45 controls were recruited. Reflexive saccades, antisaccades and smooth pursuit were examined using infra-red oculography and all subjects then underwent neuropsychological evaluation. Reflexive saccades were found to be slower in bulbar-onset compared to spinal-onset patients and controls (p = 0.03, p = 0.05). Antisaccade latency (p = 0.01) and antisaccade type 1 errors (p = 0.03, p = 0.04) were increased in patients compared to controls. 'Proportion of time spent in smooth pursuit' and smooth pursuit 'velocity gain' were reduced in patients compared to controls (p = 0.000, p = 0.001). Antisaccade errors and velocity gain correlated with neuropsychological measures sensitive to lesions of the frontal lobes. This is the first study to highlight the presence of slow saccades in bulbar-onset MND. These findings suggest that slow saccades may be due to increased brainstem pathology in bulbar-onset disease that involves burst cell neurons. Furthermore these observations highlight the potential for overlap between bulbar-onset MND and progressive supranuclear palsy (PSP) as both can have a bulbar palsy and slowed saccades.

  13. Late-onset alopecia areata: descriptive analysis of 30 cases*

    Science.gov (United States)

    Lazzarini, Rosana; Oliari, Camila Bilac; Erthal, Ana Luisa Nasser

    2016-01-01

    Alopecia areata is an autoimmune disease characterized by non-scaring hair loss. The onset in over 50-year-old patients is rare and has barely been studied. Cases of this disease have been retrospectively analyzed – according to clinical forms, extension, and associated diseases – to assess alopecia areata characteristics in a group of patients whose disease onset was after the age of 50. 30 patients were studied; a few of them presented with autoimmune-related diseases or family history. The disease onset after the age of 50 seems to have different characteristics from those found in young people. PMID:28099618

  14. A composite study of onset of the Australian summer monsoon

    Science.gov (United States)

    Hendon, Harry H.; Liebmann, Brant

    1990-01-01

    The circulation changes that accompany an onset (defined as the first occurrence of wet 850-mb westerly winds at Darwin, Australia) of the Australian summer monsoon are documented by a composite study for the years 1957-1987. Composites of atmospheric fields at stations in and about the Australian tropics are constructed relative to the onset data at Darwin. It is shown that the composite onset is dominated by a slow eastward migration of a deep-baroclinic convective circulation displaced south of the equator. This propagating anomaly exhibited many features of the so-called 40-50 day oscillation, including an upper level anticyclone that accompanies the convective anomaly.

  15. Time between the onset and diagnosis of dengue fever and related influencing factors in China%中国登革热患者发病至确诊间隔时间及其影响因素分析

    Institute of Scientific and Technical Information of China (English)

    王成岗; 刘起勇; 姜宝法

    2012-01-01

    目的 分析中国登革热患者发病至确诊间隔时间(间隔时间)及其影响因素.方法 对传染病监测信息系统中的数据进行描述性分析,采用非参数检验和logistic回归分析间隔时间的影响因素.结果 发病至确诊间隔时间呈正偏态分布,中位数为6d,四分位数间距为4d,有57.8%的患者间隔时间>5d.影响因素分析显示输入病例、年长者、非流行季节及福建、云南和浙江省的病例间隔时间较长.输入病例间隔时间中位数为6d,比本地病例多1d;非流行月份比流行月份、隔时间中位数多1d;福建、云南省间隔时间中位数为7d,比广东省多1d;20岁以下患者间隔时间中位数为5d,较20岁以上人群少1天.结论 大部分登革热患者在病毒血症期不能被确诊,需要增强监测系统的敏感性,尤其是在登革热的流行地区和非流行季节.%Objective To study the time between the onset and diagnosis of Dengue fever and its influencing factors in China.Methods Data were obtained from the Infectious Disease Surveillance System (IDSS).Descriptive analysis was performed for the time interval while nonparametric tests and logistic regression analysis were used to study the related influencing factors.Results Time interval appeared positively skewed with distribution at median of 6 days,quartile range as 4 days,while 57.8% of them were longer than five days.Data showed that patients with longer intervals among the imported cases,being elderly,cases in non-endemic season and provinces as Fujian,Yunnan and Zhejiang appeared to have had greater influences on the disease.Median of those imported cases was six days,one day longer than locally generated cases,while median of the nonepidemic month was one day more than that of the epidemic month.In Fujian and Yunnan provinces,the medians were 7 days,one day more than that from Guangdong province.The median among young people was 5 days,one day less than that of the patients

  16. [Acute-Onset Chronic Inflammatory Demyelinating Polyradiculoneuropathy].

    Science.gov (United States)

    Kanbayashi, Takamichi; Sonoo, Masahiro

    2015-11-01

    Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by an insidious onset showing progression over two months. However, up to 16% of CIDP patients may show acute presentation similar to Guillain-Barré syndrome (GBS). Such cases are termed acute-onset CIDP (A-CIDP). Distinguishing A-CIDP from GBS, especially the acute inflammatory demyelinating polyneuropathy (AIDP) subtype, is critical because therapeutic strategies and outcomes may differ between the two syndromes. Regarding clinical features, A-CIDP is less likely to have autonomic nervous system involvement, facial weakness, a preceding infectious illness, or the need for mechanical ventilation, in comparison with AIDP. Electrophysiological features are usually quite similar between the two, although follow-up studies may elucidate key differences. Around 8%-16% of GBS patients may show clinical deterioration shortly after improvement or stabilization following initial immunological therapy. Such a situation is termed treatment-related fluctuation (TRF; GBS-TRF). The distinction between GBS-TRF and A-CIDP is an important clinical issue because maintenance treatment is often required in CIDP. The diagnosis of A-CIDP should be considered when the condition of a patient with GBS deteriorates after nine weeks from onset, or when deterioration occurs three times or more.

  17. Fetal onset of general movements

    NARCIS (Netherlands)

    Luechinger, Annemarie B.; Hadders-Algra, Mijna; Van Kan, Colette M.; de Vries, JIP

    2008-01-01

    Perinatal qualitative assessment of general movements (GMs) is a tool to evaluate the integrity of the young nervous system. The aim of this investigation was to study the emergence of GMs. Fetal onset of GMs was studied sonographically in 18 fetuses during the first trimester of uncomplicated in vi

  18. Late onset startle induced tics

    NARCIS (Netherlands)

    Tijssen, MAJ; Brown, P; Morris, HR; Lees, A

    1999-01-01

    Three cases of late onset Gilles de la Tourette's syndrome are presented. The motor ties were mainly induced by an unexpected startling stimulus, but the startle reflex was not exaggerated. The ties developed after physical trauma or a period of undue emotional stress. Reflex ties may occur in

  19. Late onset startle induced tics

    NARCIS (Netherlands)

    Tijssen, MAJ; Brown, P; Morris, HR; Lees, A

    1999-01-01

    Three cases of late onset Gilles de la Tourette's syndrome are presented. The motor ties were mainly induced by an unexpected startling stimulus, but the startle reflex was not exaggerated. The ties developed after physical trauma or a period of undue emotional stress. Reflex ties may occur in Gille

  20. 76 FR 35346 - Airworthiness Directives; Eurocopter France Model SA-365C, SA-365C1, SA-365C2, SA-365N, SA-365N1...

    Science.gov (United States)

    2011-06-17

    ... high amplitude vibrations in flight, compelling the pilot to make a precautionary landing. The actions... two of these cases, the deterioration caused high amplitude vibrations in flight, compelling the pilot...-amplitude vibrations could make it difficult to control the helicopter. Related Service...

  1. Software reference for SaTool - a Tool for Structural Analysis of Automated Systems

    DEFF Research Database (Denmark)

    Lorentzen, Torsten; Blanke, Mogens

    2004-01-01

    This software reference details the functions of SaTool – a tool for structural analysis of technical systems. SaTool is intended used as part of an industrial systems design cycle. Structural analysis is a graph-based technique where principal relations between variables express the system......’s properties. Measured and controlled quantities in the system are related to variables through functional relations, which need only be stated as names, their explicit composition need not be described to the tool. The user enters a list of these relations that together describe the entirerity of the system....... The list of such variables and functional relations constitute the system’s structure graph. Normal operation means all functional relations are intact. Should faults occur, one or more functional relations cease to be valid. In a structure graph, this is seen as the disappearance of one or more nodes...

  2. DAYA SAING TEH INDONESIA DI PASAR INTERNASIONAL

    Directory of Open Access Journals (Sweden)

    Fadhilah Ramadhani

    2013-11-01

    Full Text Available Abstrak ___________________________________________________________________ Teh merupakan komoditas sub sektor perkebunan yang pernah mengalami kejayaan selama dua puluh tahun terakhir. Namun dari tahun ke tahun peringkat teh Indonesia di pasar internasional terus mengalami penurunan. Penurunan tersebut dari peringkat ke dua dunia menjadi peringkat ke enam dunia. Hal ini diduga karena lemahnya daya saing produk teh Indonesia di pasar internasional. Adapun tujuan penelitian ini untuk mengkaji perkembangan daya saing teh Indonesia di pasar internasional serta faktor yang mempengaruhi posisi daya saing tesebut. Metode analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif untuk hasil uji Import Dependency Ratio (IDR, Self Sufficiency Ratio (SSR, dan  Revealed Comparative Advantage (RCA. Selanjutnya hasil nilai Revealed Comparative Advantage (RCA akan diregresi dengan metode Ordinary Least Square (OLS.  Berdasarkan hasil uji Import Dependency Ratio (IDR mendapatkan nilai 0 persen hingga 16 persen yang menunjukkan Indonesia tidak mempunyai ketergantungan terhadap produk impor teh. Sedangkan nilai Self Sufficiency Ratio (SSR menunjukkan nilai 280,015 persen, artinya produksi teh Indonesia cukup untuk memenuhi kebutuhan dalam negeri dan ekspor. Dengan nilai daya saing yang cukup kuat, dilihat dari nilai Revealed Comparative Advantage (RCA sebesar 6,790. Hasil uji regresi Ordinary Least Square (OLS terdahap Revealed Comparative Advantage (RCA, menunjukkan kurs rill dan harga riil berpengaruh secara signifikan terhadap posisi daya saing teh indonesia di pasar internasional pada α = 5%. Produksi teh Indonesia tidak berpengaruh terhadap posisi daya saing dengan α = 5%. Abstract ______________________________________________________________ Tea is plantation commodity has been experienced triumph over the last twenty years. But every years ratings Indonesia tea in international markets continues to decline. The decline Indonesia

  3. Draft Genome Sequence of the Phosphate-Solubilizing Bacterium Pseudomonas argentinensis Strain SA190 Isolated from the Desert Plant Indigofera argentea

    KAUST Repository

    Lafi, Feras Fawzi

    2016-12-23

    Pseudomonas argentinensis strain SA190 is a plant endophytic-inhabiting bacterium that was isolated from root nodules of the desert plant Indigofera argentea collected from the Jizan region of Saudi Arabia. Here, we report the genome sequence of SA190, highlighting several functional genes related to plant growth-promoting activity, environment adaption, and antifungal activity.

  4. Manufacturing of JT-60SA Cryostat Base

    Energy Technology Data Exchange (ETDEWEB)

    Medrano, Mercedes, E-mail: mercedes.medrano@ciemat.es [Association EURATOM – CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Alonso, Javier; Botija, José; Fernández, Pilar; Ramos, Francisco; Rincon, Esther; Soleto, Alfonso [Association EURATOM – CIEMAT, Avda. Complutense 40, 28040 Madrid (Spain); Davis, Sam; Di Pietro, Enrico [Fusion for Energy, JT-60SA European Home Team, 85748 Garching bei Munchen (Germany); Masaki, Kei; Sakasai, Akira [JAEA, Japan Atomic Energy Agency, Naka Fusion Institute, Ibaraki 311-0193 (Japan)

    2013-10-15

    Highlights: ► JT-60SA Cryostat Base has been fabricated in seven structures fastened by bolts. ► The pieces are fully welded structures further machined to get required tolerances. ► The pre-assembly of the Cryostat Base will be done at the factory to check final tolerances as well as to anticipate problems which could be encountered during final assembly. -- Abstract: JT-60SA is a superconducting tokamak to be assembled and operated at the JAEA laboratories in Naka (Japan) [1]. The tokamak has been designed to prepare, support and complement the ITER experimental programme and will be manufactured and operated under the funding of the Broader Approach Agreement (between the government of Japan and the European Commission) and of the Japan Fusion National Programme. Within the European contribution to JT-60SA, Spain has to provide the cryostat. Due to functional purposes, the cryostat has been divided in two large assemblies: the Cryostat Base (CB) and the Cryostat Vessel Body the latter subdivided into Cryostat Vessel Body Cylindrical Section (CVBCS) and the Top Lid. Spain is committed to provide the design and subsequent manufacturing of the CB and CVBCS (excluding the Top Lid) through the National Laboratory of Fusion at Ciemat. The design of both components has been concluded and the CB is currently being manufactured by a Spanish company, IDESA. This paper aims to present the status of the manufacturing and pre-assembly at the factory of the CB that has to be delivered in November 2012.

  5. AGREEMENT BETWEEN CERN AND UBS SA

    CERN Multimedia

    2002-01-01

    We wish to inform you that the agreement between CERN and UBS SA has been renewed for a period of five years with effect from 1st July 2002. This represents the culmination of work carried out since 1999 by a group consisting of representatives of the Finance Division, the SPL Division, the Staff Association and the Users Office. After analysis of the results of a market survey, it emerged that OVERALL the UBS offered the best conditions and guarantees for the CERN personnel. Owing to developments in the banking market, new conditions have had to be negotiated, which will be presented to you by the UBS (see article).

  6. The dawn and dusk electrojet response to substorm onset

    Directory of Open Access Journals (Sweden)

    E. Borälv

    Full Text Available We have investigated the time delay between substorm onset and related reactions in the dawn and dusk ionospheric electrojets, clearly separated from the nightside located substorm current wedge by several hours in MLT. We looked for substorm onsets occurring over Greenland, where the onset was identified by a LANL satellite and DMI magnetometers located on Greenland. With this setup the MARIA magnetometer network was located at dusk, monitoring the eastward electrojet, and the IMAGE chain at dawn, for the westward jet. In the first few minutes following substorm onset, sudden enhancements of the electrojets were identified by looking for rapid changes in magnetograms. These results show that the speed of information transfer between the region of onset and the dawn and dusk ionosphere is very high. A number of events where the reaction seemed to preceed the onset were explained by either unfavorable instrument locations, preventing proper onset timing, or by the inner magnetosphere's reaction to the Earthward fast flows from the near-Earth neutral line model. Case studies with ionospheric coherent (SuperDARN and incoherent (EISCAT radars have been performed to see whether a convection-induced electric field or enhanced conductivity is the main agent for the reactions in the electrojets. The results indicate an imposed electric field enhancement.

    Key words: Ionosphere (auroral ionosphere; electric fields and currents - Magnetospheric physics (storms and substorms

  7. Perfil de saúde dos trabalhadores de um Centro de Saúde-Escola

    Directory of Open Access Journals (Sweden)

    Nascimento Lucila Castanheira

    2002-01-01

    Full Text Available O estudo buscou descrever o perfil de saúde dos trabalhadores (184 de um Centro de Saúde-Escola de Ribeirão Preto, sob a perspectiva da Promoção de Saúde, modelo epidemiológico de Blum e fatores de risco para doenças crônico-degenerativas. Foi realizado estudo descritivo utilizando-se entrevista estruturada. Concluiu-se que os trabalhadores eram predominantemente do sexo feminino, faixa etária de 35 a 39 anos e escolaridade "superior completo". Dentre os achados, constatou-se que 61,9% tinham sobrepeso e obesidade; a hipertensão foi detectada em 33,1%; 41 (22,3% apresentaram pressão arterial acima do nível da normalidade e a obesidade mostrou-se presente em mais da metade dos indivíduos com pressão arterial alterada. Os dados possibilitaram explorar riscos autocriados para as doenças crônico-degenerativas; identificar fatores relacionados à promoção de saúde e prevenção de doenças e refletir sobre o autocuidado e auto-responsabilidade, visando à qualidade de vida que desfrutarão, em decorrência da transição demográfica e epidemiológica que vivenciamos.

  8. Homens e saúde na pauta da Saúde Coletiva Men and health as targets of the Public Health

    Directory of Open Access Journals (Sweden)

    Lília Blima Schraiber

    2005-03-01

    Full Text Available Apresenta-se a temática "homens e saúde" como questão contemporânea da Saúde Coletiva e produto da interface entre as ciências humanas e a saúde: o caráter social do adoecimento; a perspectiva de gênero como forma particular da relação saúde-sociedade; e a promoção da saúde como conceituação positiva Elabora-se a temática em torno de três eixos de aproximação, sob a perspectiva dos exercícios das masculinidades: saúde sexual e reprodutiva; violência e gênero e morbi-mortalidade em homens. São apontadas as contribuições que estes eixos produzem como esforço empírico para realizar a categoria gênero, ao tempo em que revelam novas problemáticas para a área de saúde: a paternidade, o exercício interativo da sexualidade, a violência interpessoal no âmbito da vida privada, a hiper-masculinidade na violência entre homens, o cuidado de si e o cuidar em saúde para os homens. Estas contribuições permitirão não apenas inserir as masculinidades como questão de saúde, mas renovar as formas de tratamento de homens e mulheres no campo da saúde.It shows the thematic "men and health" as a contemporary matter of the Public Health and interface product among human sciences and health: the social view of illness; the gender perspective as a particular form of the relation health-society and the health promotion while positive means of health. It elaborates the thematic around three approach axises, conformed in the relation between men and health from the perspective of exercises of the masculinity: sexual and reproductive health; violence and gender, and morbid-mortality in men. The contributions that these axises produce are mentioned as empiric effort to accomplish the category gender, the time in which they reveal health new problems to the health's area: the paternity, the interactive exercise of the sexuality, the interpersonal violence in life closet scope, the hipper-masculinity in the violence among men, the

  9. O impacto do baixo peso ao nascer relacionado à depressão gestacional para o financiamento federal da saúde pública: uma análise do Município de Pelotas, Rio Grande do Sul, Brasil The impact of low birth weight related to gestational depression on Federal funding of public health: a study in Pelotas, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Leticia Oliveira de Menezes

    2012-10-01

    Full Text Available O baixo peso ao nascer está relacionado com morbimortalidade e sequelas no desenvolvimento infantil, impactando nos custos dos sistemas de saúde, por isso é importante avaliar fatores que o influenciam, estimando seu impacto no Sistema Único de Saúde (SUS. Este é um estudo prospectivo aninhado a uma coorte de gestantes que realizaram pré-natal e parto exclusivamente pelo SUS nos hospitais com UTI da cidade de Pelotas, Rio Grande do Sul, Brasil. Entre os resultados, concluiu-se que mães com episódios de depressão gestacional apresentam quase quatro vezes mais chances de ter um filho com baixo peso ao nascer (RP = 3,94; IC: 1,49-10,36. Valendo-se do cálculo da fração atribuível na população, estima-se que, na população geral, 36,17% dos bebês com baixo peso ao nascer são filhos de mães que tiveram episódio depressivo, estimando-se um custo que pode chegar a mais de R$ 76 milhões no Brasil. Sugere-se que se ampliem as ações preventivas e curativas para as gestantes na área da saúde mental, possibilitando melhor desfecho de saúde dos recém-nascidos, e que se utilizem adequadamente os recursos do SUS.Low birth weight is related to morbidity and mortality and sequelae during infant development, thereby impacting health system costs. It is thus important to evaluate factors that influence low birth weight and to estimate their impact on the Brazilian Unified National Health System (SUS. This was a nested prospective study in a cohort of pregnant women who received prenatal care and gave birth in the National Health System in hospitals with ICUs in the city of Pelotas, Rio Grande do Sul State, Brazil. Gestational depression was associated with a fourfold risk of low birth weight (PR = 3.94; CI: 1.49-10.36. Based on the population-attributable fraction, in the overall population an estimated 36.17% of low birth weight infants are born to mothers with an episode of depression during pregnancy, with an estimated cost of more

  10. Diferenças na adesão ao tratamento da tuberculose em relação ao sexo no distrito de saúde da Freguesia do Ó/Brasilândia - São Paulo Differences in the adherence to tuberculosis treatment in relation to sex in the health district of Freguesia do Ó/ Brasilândia - São Paulo

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    Raquel Queiroz

    2010-09-01

    Full Text Available Os motivos para as diferenças epidemiológicas e para a adesão ao tratamento da tuberculose em relação a homens e mulheres são desconhecidos. Este trabalho tem como objetivo verificar diferenças na adesão ao tratamento da tuberculose em relação ao sexo; identificar aspectos facilitadores e dificultadores para a adesão ao tratamento da tuberculose em relação ao sexo; analisar as crenças consideradas importantes para a adesão ao tratamento da tuberculose. Foi utilizado o referencial teórico do Modelo de Crenças em Saúde de Rosenstock e a técnica da Análise de Conteúdos de Bardin. Foram realizadas 28 entrevistas semiestruturadas com homens e mulheres em tratamento supervisionado de tuberculose do Distrito de Saúde da Freguesia do Ó/Brasilândia. Os resultados mostraram que o perfil daqueles que falharam na terapêutica da tuberculose em relação ao sexo foi: mulher - solteira e separada, com atividade remunerada não comprovada, nível de escolaridade entre fundamental I completo e ensino médio completo; homem - casado, com atividade remunerada comprovada, nível de escolaridade entre ensino fundamental II completo e ensino médio completo. Os aspectos facilitadores encontrados para a boa adesão residem no bom atendimento dos profissionais de saúde e na percepção, por parte do paciente, da sua melhora de saúde. As crenças para a boa adesão ao tratamento no sexo masculino e feminino foram: bom atendimento do serviço de saúde e bom tratamento (em relação aos medicamentos.The reasons for epidemiological differences and for adherence to tuberculosis treatment in men and women are unknown. This study aims to determine differences in adherence to tuberculosis treatment in relation to sex; to identify facilitating and hindering aspects for adherence to tuberculosis treatment in relation to sex; to analyze the beliefs that are considered important for adherence to tuberculosis treatment. We used the theoretical framework

  11. North America and South America (NA-SA) neuropathy project.

    Science.gov (United States)

    Pasnoor, Mamatha; Nascimento, Osvaldo J M; Trivedi, Jaya; Wolfe, Gil I; Nations, Sharon; Herbelin, Laura; de Freitas, M G; Quintanilha, Giseli; Khan, Saud; Dimachkie, Mazen; Barohn, Richard

    2013-08-01

    Peripheral neuropathy is a common neurological disorder. There may be important differences and similarities in the diagnosis of peripheral neuropathy between North America (NA) and South America (SA). Neuromuscular databases were searched for neuropathy diagnosis at two North American sites, University of Kansas Medical Center and University of Texas Southwestern Medical Center, and one South American site, Federal Fluminense University in Brazil. All patients were included into one of the six major categories: immune-mediated, diabetic, hereditary, infectious/inflammatory, systemic/metabolic/toxic (not diabetic) and cryptogenic. A comparison of the number of patients in each category was made between North America and South America databases. Total number of cases in North America was 1090 and in South America was 1034 [immune-mediated: NA 215 (19.7%), SA 191 (18%); diabetic: NA 148 (13.5%), SA 236 (23%); hereditary: NA 292 (26.7%), SA 103 (10%); infectious/inflammatory: NA 53 (4.8%), SA 141 (14%); systemic/metabolic/toxic: NA 71 (6.5%), SA 124 (12%); cryptogenic: NA 311 (28.5%), SA 239 (23%)]. Some specific neuropathy comparisons were hereditary neuropathies [Charcot-Marie-Tooth (CMT) cases] in NA 246/292 (84.2%) and SA 60/103 (58%); familial amyloid neuropathy in SA 31/103 (30%) and none in NA. Among infectious neuropathies, cases of human T-lymphotropic virus type 1 (HTLV-1) neuropathy in SA were 36/141(25%), Chagas disease in SA were 13/141(9%) and none for either in NA; cases of neuropathy due to leprosy in NA were 26/53 (49%) and in SA were 39/141(28%). South American tertiary care centers are more likely to see patients with infectious, diabetic and hereditary disorders such as familial amyloid neuropathies. North American tertiary centers are more likely to see patients with CMT. Immune neuropathies and cryptogenic neuropathies were seen equally in North America and South America.

  12. Adultos e idosos em hemodiálise: avaliação da qualidade de vida relacionada à saúde Adultos y ancianos com hemodiálisis: evaluación de la calidad de vida relacionada a la salud Adults and elderly on hemodialysis evaluation of health related quality of life

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    Luciana Kusumoto

    2008-01-01

    Full Text Available OBJETIVOS: Caracterizar os adultos e idosos em hemodiálise residentes em Ribeirão Preto-SP. Avaliar e descrever as diferenças na Qualidade de Vida Relacionada à Saúde (QVRS desses pacientes. MÉTODOS: Estudo seccional e populacional com 194 pacientes em hemodiálise em quatro serviços de diálise do município. Os instrumentos utilizados foram: para caracterização da população, Mini Exame do Estado Mental e Kidney Disease and Quality of Life-Short Form (KDQOL-SF TM. RESULTADOS: Dos pacientes, 132 eram adultos e 62 idosos. Foram encontradas diferenças entre os escores médios dos dois grupos, com significância estatística nas dimensões do KDQOL-SF TM: Funcionamento físico, Função física, emocional, Sobrecarga da doença renal e Estímulo da equipe de diálise. CONCLUSÃO: A insuficiência renal crônica terminal e a hemodiálise se relacionaram com a QVRS dos adultos e idosos. Os resultados podem subsidiar a atuação dos profissionais da saúde para atender as necessidades iminentes, prevenir complicações, enfim almejar uma melhor QVRS.OBJETIVOS: Caracterizar a los adultos y ancianos con hemodiálisis residentes en Ribeirão Preto-SP. Evaluar y describir las diferencias en la Calidad de Vida Relacionada a la Salud (CVRS de esos pacientes. MÉTODOS: Estudio seccional y poblacional realizado con 194 pacientes con hemodiálisis en cuatro servicios de diálisis del municipio. Los instrumentos utilizados fueron: para caracterización de la población, Mini Examen del Estado Mental y Kidney Disease and Quality of Life-Short Form (KDQOL-SF TM. RESULTADOS: Del total de pacientes, 132 eran adultos y 62 ancianos. Se encontraron diferencias entre los escores medios de los dos grupos, con significancia estadística en las dimensiones del KDQOL-SF TM: Funcionamiento físico, Función física, emocional, Sobrecarga de la enfermedad renal y Estímulo del equipo de diálisis. CONCLUSIÓN: La insuficiencia renal crónica terminal y la hemodi

  13. Percepção dos profissionais de saúde sobre a comunicação com os familiares de pacientes em UTIs Percepción de los profesionales de salud con respecto a la comunicación con los familiares de pacientes en UTIs Perception of helthcare professionals about communication with relatives of ICU patients

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    Kátia Massuda Alves Batista dos Santos

    2006-02-01

    Full Text Available A pesquisa objetivou verificar como os profissionais de saúde percebem a comunicação com os familiares de pacientes internados em UTI. A coleta de dados foi realizada em um hospital privado e envolveu 37 profissionais de saúde, sendo obtida por meio de entrevistas semi-estruturadas, gravadas em fita cassete. A análise de conteúdo demonstrou duas grandes categorias: aspectos que dificultam a comunicação com os familiares e aspectos que facilitam a comunicação com os familiares. Os aspectos que dificultam a interação sobressaíram-se em relação aos que facilitam: informações nem sempre compreendidas pelos familiares, a gravidade do paciente, a dinâmica da unidade, o grau de desconhecimento pelo profissional da evolução clínica do paciente, dificuldades no jeito de ser do profissional e o espaço físico inadequado.Este estudio tuvo como objectivo verificar como los profisionales de la salud perciben la comunicacción con los familiares de pacientes internados en la UTI. La recolecta de datos fue realizada en un hospital particular y envolvió 37 profesionales de salud. La recolecta fue hecha a través de entrevistas semi-estructuradas. El análisis del contenido demostró dos grandes categorías: aspectos que dificultan la comunicación con los familiares y aspectos que facilitan la comunicación con los familiares. Los aspectos que dificultan la interacción se sobresalen en relación a los que facilitan; informaciones no siempre comprendidas por los familiares, la gravedad del paciente, la dinámica de la unidad, el grado de desconocimiento por el profisional de la evolución clínica del paciente, dificultades en la manera de ser del profisional y el espacio físico inadecuado.This study aimed at verifying how health professionals proceed the communication with the patient's relatives at the ICU. Data collection was carried out in a private hospital with 37 health professionals and was obtained by means of semi

  14. Saúde Coletiva: um desafio para a enfermagem

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    Matumoto Silvia

    2001-01-01

    Full Text Available O texto parte da saúde pública para discutir o que é saúde coletiva, seu objeto e campo de atuação, dando ênfase à concepção de homem, à discussão a respeito do âmbito individual e coletivo e ao conceito de saúde-doença, passando pelo debate da construção interdisciplinar da saúde coletiva. Em seguida, busca situar a enfermagem nesse campo, destacando aquilo que parece ser um grande desafio, compreender a enfermagem como prática de relações.

  15. Saúde mental e economia solidária: análise das relações de trabalho em uma cooperativa de confecção de Porto Alegre Mental health and solidarity economy: analysis of labor relations in a manufacture co-operative in Porto Alegre

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    Kátia Salete Barfknecht

    2006-08-01

    Full Text Available Este artigo aborda as vinculações entre o prazer, sofrimento e a organização do trabalho no cotidiano dos trabalhadores de uma cooperativa inserida no movimento da Economia Solidária. Como proposta do estudo, articulamos uma interpretação macro social do contexto socioeconômico, com uma análise micro social baseada na perspectiva da Psicodinâmica do Trabalho. Analisamos, em conjunto com os trabalhadores, as atividades de corte, costura e serigrafia desenvolvidas no empreendimento solidário. Os resultados apontaram para a identificação dos trabalhadores com o cooperativismo, bem como com a possibilidade das relações solidárias e do gerenciamento, transformando o sofrimento em prazer, favorecendo a saúde mental através da rediscussão constante da organização do trabalho e da criação de novos modos de viver o trabalho.This article focuses on the links of pleasure, distress, and work organization in the everyday life of workers of a cooperative associated with the social economy movement. Our research proposal seeks to articulate a macro-social interpretation of the socioeconomic context with a micro-social analysis based on the Work Psychodynamic theory. We have analyzed, with the workers, cutting, sewing, and silk-screen activities developed in the solidarity enterprise. The results have pointed out workers' identification with co-operativism, as well as with the possibility of the solidarity relations and management converting distress into pleasure, promoting the mental health through the continuous re-discussion of work organization and the creation of new ways of experiencing work.

  16. Analysis of related factors of endometrial polyps after the onset of menopause%绝经后妇女子宫内膜息肉发病相关因素分析

    Institute of Scientific and Technical Information of China (English)

    曾婷; 李晓斌; 曾晓娟

    2016-01-01

    history of hormone therapy were the related factors of EP (P<0.05). The number of pregnancies and the number of production were the protective factor of EP (P<0.05). Logistic multivariate analysis showed that obesity, cervical polyps, chronic endometritis, adenomyosis, postmenopausal hormone therapy were the independent risk factors of EP (OR=2.602, 2.733, 1.871, 2.467, 3.689, P<0.05). Conclusion Obesity, cervical polyps, chronic endometritis, adenomyosis and postmenopausal hormone therapy were independent risk factors of EP af-ter the onset of menopause, and high blood pressure also presents a higher risk of occurrence of EP. The number of preg-nancies and the number of production may be the protective factors of EP.

  17. The activated SA and JA signaling pathways have an influence on flg22-triggered oxidative burst and callose deposition.

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    So Young Yi

    Full Text Available The first line of defense in plants against pathogens is induced by the recognition of microbe-associated molecular patterns (MAMP. Perception of bacterial flagellin (flg22 by the pattern recognition receptor flagellin-sensing 2 (FLS2 is the best characterized MAMP response, although the underlying molecular mechanisms are not fully understood. Here we studied the relationship between salicylic acid (SA or jasmonic acid (JA signaling and FLS2-mediated signaling by monitoring flg22-triggered responses in known SA or JA related mutants of Arabidopsis thaliana (L. Heynh. The sid2 mutant, impaired in SA biosynthesis, had less basal FLS2 mRNA accumulation than the wild type, which correlated with suppression of early flg22 responses such as ROS production and induction of marker genes, WRKY29 and FRK1. The JA-signaling mutants, jar1 and coi1, exhibited an enhanced flg22-triggered oxidative burst and more callose accumulation than the wild type, and pretreatment with SA or coronatine (COR, a structural mimic of JA-isoleucine, altered these flg22-induced responses. Nonexpressor of pathogenesis-related genes 1 (NPR1 acted downstream of SID2 and required SA-dependent priming for the enhanced flg22-triggered oxidative burst and callose deposition. Activation of JA signaling by COR pretreatment suppressed the flg22-triggered oxidative burst and callose accumulation in a coronatine insensitive 1 (COI1 dependent manner. COR had a negative effect on flg22 responses but only the flg22-triggered oxidative burst depended on SA-JA/COR signaling antagonism. Thus the activated SA and JA signaling pathways have an influence on flg22-triggered oxidative burst and callose deposition. These results may explain how SA and JA signaling are cross talked for regulation of flg22-triggered responses.

  18. Age at onset mixture analysis and systematic comparison in schizophrenia spectrum disorders: Is the onset heterogeneity dependent on heterogeneous diagnosis?

    Science.gov (United States)

    Nowrouzi, Behdin; Kamhi, Roy; Hu, Jayi; Kennedy, James L; Matmari, Michelle; De Luca, Vincenzo

    2015-05-01

    A major obstacle to the identification of the neurobiological correlates of schizophrenia is the substantial diagnostic heterogeneity of this disorder. Dividing schizophrenia into "early" and "late" subtypes may reduce heterogeneity and facilitate identification of biomarkers related to this disease. Our objective was to assess the presence of different sub-groups in schizophrenia by age at onset analysis. The participants in this study were 612 unrelated patients with schizophrenia. Admixture analysis was applied in order to identify a model of separate normal distributions of age at onset characterized by different means, variances and population proportions to evaluate the effect of winter birth and ethnicity on early onset schizophrenia. The best-fitting model suggested three subgroups with means and standard deviations of 17.11 ± 2.09, 21.96 ± 3.43 and 30.02 ± 7.1 years, comprising 34.6%, 42.6% and 22.8% of the sample respectively. We considered as predictors of early onset schizophrenia: male gender, winter birth, white ethnicity and positive family history for psychiatric disorders. Earlier onset was significantly associated with male gender. We also compared our age at onset distribution with those published in other studies and we found significant differences with several studies suggesting heterogeneity in age at onset that is likely influenced by diagnostic heterogeneity in applying the DSM-IV criteria. Overall, our study showed that a typical early onset schizophrenia patient is more likely to be a white male with cannabis abuse and positive family history of psychiatric disorders. The heterogeneity in reporting age at onset across different studies suggests the application of more stringent criteria in diagnosing schizophrenia. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. The onset of nonmotor symptoms in Parkinson's disease (the ONSET PD study).

    Science.gov (United States)

    Pont-Sunyer, Claustre; Hotter, Anna; Gaig, Carles; Seppi, Klaus; Compta, Yaroslau; Katzenschlager, Regina; Mas, Natalia; Hofeneder, Dominik; Brücke, Thomas; Bayés, Angels; Wenzel, Karoline; Infante, Jon; Zach, Heidemarie; Pirker, Walter; Posada, Ignacio J; Álvarez, Ramiro; Ispierto, Lourdes; De Fàbregues, Oriol; Callén, Antoni; Palasí, Antoni; Aguilar, Miquel; Martí, Maria José; Valldeoriola, Francesc; Salamero, Manel; Poewe, Werner; Tolosa, Eduardo

    2015-02-01

    Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe the presence and perceived onset of NMS in PD as well as their possible association with motor phenotype. Presence and onset of NMS were assessed by a custom-made questionnaire in 109 newly diagnosed untreated PD patients and 107 controls from 11 Spanish and Austrian centers. Seventeen of thirty-one NMS were more common in patients than controls (P symptoms. Anhedonia, apathy, memory complaints, and inattention occurred more frequently during the 2-year premotor period. Those reported more frequently in the 2- to 10-year premotor period were smell loss, mood disturbances, taste loss, excessive sweating, fatigue, and pain. Constipation, dream-enacting behavior, excessive daytime sleepiness, and postprandial fullness were frequently perceived more than 10 years before motor symptoms. No correlation between NMS burden and motor severity, age, or gender was observed. NMS associated in four clusters: rapid eye movement sleep behavior disorder symptoms-constipation, cognition-related, mood-related, and sensory clusters. No cluster was associated with a specific motor phenotype or severity. NMS are common in early unmedicated PD and frequently reported to occur in the premotor period. They are generally mild, but a patient subgroup showed high NMS burden mainly resulting from cognition-related symptoms. Certain NMS when present at the time of assessment or in the premotor stage, either alone or in combination, allowed discriminating PD from controls.

  20. Early- versus Late-Onset Fetal Growth Restriction Differentially Affects the Development of the Fetal Sheep Brain.

    Science.gov (United States)

    Alves de Alencar Rocha, Anna Karynna; Allison, Beth J; Yawno, Tamara; Polglase, Graeme R; Sutherland, Amy E; Malhotra, Atul; Jenkin, Graham; Castillo-Melendez, Margie; Miller, Suzanne L

    2017-01-01

    Fetal growth restriction (FGR) is a common complication of pregnancy, principally caused by suboptimal placental function, and is associated with high rates of perinatal mortality and morbidity. Clinical studies suggest that the time of onset of placental insufficiency is an important contributor towards the neurodevelopmental impairments that are evident in children who had FGR. It is however currently unknown how early-onset and late-onset FGR differentially affect brain development. The aim of this study was to examine neuropathology in early-onset and late-onset FGR fetal sheep and to determine whether they differentially alter brain development. We induced placental insufficiency and FGR via single umbilical artery ligation at either 88 days (early-onset) or 105 days (late-onset) of fetal sheep gestation (term is approx. 147 days), reflecting a period of rapid white matter brain development. Fetal blood samples were collected for the first 10 days after surgery, and all fetuses were sacrificed at 125 days' gestation for brain collection and subsequent histopathology. Our results show that early-onset FGR fetuses became progressively hypoxic over the first 10 days after onset of placental insufficiency, whereas late-onset FGR fetuses were significantly hypoxic compared to controls from day 1 after onset of placental insufficiency (SaO2 46.7 ± 7.4 vs. 65.7 ± 3.9%, respectively, p = 0.03). Compared to control brains, early-onset FGR brains showed widespread white matter injury, with a reduction in both CNPase-positive and MBP-positive density of staining in the periventricular white matter (PVWM), subcortical white matter, intragyral white matter (IGWM), subventricular zone (SVZ), and external capsule (p development that principally mediates altered brain development associated with FGR. © 2017 S. Karger AG, Basel.

  1. Trabalho e qualidade de vida relacionada à saúde de pacientes em diálise peritoneal Trabajo y Calidad de Vida Relacionada a la Salud de pacientes en Diálisis Peritoneal Work and health-related quality of life of patients on peritoneal dialysis

    Directory of Open Access Journals (Sweden)

    Marília Pilotto de Oliveira

    2012-01-01

    Full Text Available OBJETIVO: Descrever e comparar a Qualidade de Vida Relacionada à Saúde (QVRS de pacientes em Diálise Peritoneal (DP que tinham ou não trabalho remunerado. MÉTODOS: Estudo seccional e populacional com 82 pacientes dos dois serviços de DP de Ribeirão Preto, (SP. A coleta de dados foi realizada por entrevistas entre dezembro/2009 e março/2010. Os questionário para caracterização dos pacientes, o Miniexame do Estado Mental e o Kidney Disease and Quality of Life-Short Form foram usados. Foram feitas as análises estatística exploratória uni e bivariada e a confirmatória bivariada entre variáveis independentes e as dimensões de QVRS. RESULTADOS: os pacientes com trabalho remunerado apresentavam maiores escores médios refletindo melhor QVRS para a maioria das dimensões do instrumento utilizado. CONCLUSÃO: o trabalho é uma faceta importante da vida desses pacientes e merece a atenção dos profissionais da saúde na busca de estratégias que favoreçam e incentivem sua manutenção e reinserção no mercado de trabalho.OBJETIVO: Describir y comparar la Calidad de Vida Relacionada a la Salud (QVRS de pacientes en Diálisis Peritoneal (DP que tenían o no trabajo remunerado. MÉTODOS: Estudio seccional y poblacional realizado con 82 pacientes de los dos servicios de DP de Ribeirão Preto, (SP. La recolección de datos se realizó por medio de entrevistas entre deciembre/2009 y marzo/2010. Fueron usados los cuestionarios para la caracterización de los pacientes, el Mini examen del Estado Mental y el Kidney Disease and Quality of Life-Short Form. Se realizaron los análisis estadísticos exploratorio uni y bivariado y la confirmatoria bivariada entre variables independientes y las dimensiones de QVRS. RESULTADOS: los pacientes con trabajo remunerado presentaban mayores escores medios reflejando mejor QVRS para la mayoría de las dimensiones del instrumento utilizado. CONCLUSIÓN: el trabajo es una faceta importante de la vida de esos

  2. Uma revisão sistemática sobre a produção científica com ênfase na relação entre saúde e meio ambiente A systematic review about the scientific production with focus on the relation between health and environment

    Directory of Open Access Journals (Sweden)

    Silviamar Camponogara

    2008-04-01

    Full Text Available A discussão de questões ligadas à interface entre meio ambiente e saúde têm tomado importante dimensão na atualidade. Neste sentido, este artigo busca apresentar um levantamento da produção científica nacional e internacional sobre o assunto, visando identificar as temáticas mais freqüentes da referida produção. Os dados foram coletados durante os meses de março e abril de 2005, junto a dois portais de busca de publicações científicas disponíveis na web, sendo que 603 foram utilizadas como material de análise, por meio de categorização. Os dados evidenciaram que há um número significativo de países com produção científica na área, com supremacia de produção norte-americana e russa, cuja temática de maior relevância está relacionada com avaliação de riscos. O Brasil aparece como terceiro maior produtor, sendo que a maioria de sua produção está direcionada para o estudo de vetores transmissores de doenças infecto-contagiosas. Nos demais países, há diversificação de linhas de investigação. De uma forma geral, percebe-se que a produção de conhecimento na área ainda ocorre de forma muito isolada e fragmentada, sem valorizar a diversidade de fatores envolvidos nas questões ambientais, bem como sem dar espaço para a interdisciplinaridade e intersetorialidade tão importantes na análise da interface saúde meio ambiente.The discussion on points linked to the interface between the environment and health has turned into a very important subject of interest nowadays. Thus, this article aims to show a survey of the national and international scientific production about this subject, in an attempt to identify the most frequent themes of this production. The data were collected during the months of March and April of 2005, from two homepages where scientific publications are available on the web, from which, 603 publications were used as analysis material, by means of categorization. The data showed that

  3. Health related quality of life of women with cervical cancer Calidad de vida relacionada a la salud de mujeres con cáncer de cuello uterino Qualidade de vida relacionada à saúde de mulheres com câncer de colo uterino

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    Wanessa Cassemiro Fernandes

    2010-06-01

    Full Text Available This cross-sectional study aimed to evaluate the health related quality of life (HRQoL of women with cervical cancer and to identify predictors of quality of life. Between November 2008 and February 2009, 149 women were interviewed. The instrument Functional Assessment of Cancer Therapy-Cervix Cancer (FACT-Cx was used to assess HRQoL and, in general, the scores obtained indicated positive evaluation. The items that showed negative evaluation were: “I am interested in sex”, “I feel sexually attractive”, “I am afraid to have sex” and “My vagina feels too narrow or short”. In multiple linear regression analysis, using the backward method, of the 18 independent variables, eight were predictive of HRQoL. Self-perceived health status was the most influential factor. Special attention should be given to the sexual dysfunctions of these women after radiotherapy.Este estudio, de corte transversal, tuvo como objetivos evaluar la calidad de vida relacionada a la salud (CVRS de mujeres con cáncer de cuello uterino e identificar los factores de predicción de calidad de vida. Fueron entrevistadas 149 mujeres, en el período de noviembre de 2008 a febrero de 2009. El instrumento Functional Asesment of Cancer Therapy-Cervix Cancer (FACT-Cx fue utilizado para evaluar la CVRS y, de forma general, los puntajes obtenidos indicaron evaluación positiva. Presentaron evaluación negativa los ítems: “tengo interés en sexo”, “me siento sexualmente atrayente”, “tengo miedo de tener relaciones sexuales” y “siento la vagina estrecha o demasiada corta”. En el análisis de regresión linear múltiple, por el método backward, de las 18 variables independientes, ocho fueron factores de predicción de CVRS. La autopercepción del estado de salud fue el factor de mayor influencia. Atención especial debe ser dada a las disfunciones sexuales de esas mujeres después de la radioterapia.Este estudo, de corte transversal, teve como objetivos

  4. Comportamento e características de usuários de lentes de contato entre estudantes universitários da área de saúde The behavior and characteristics of contact lens wearers among university students in health related areas

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    Cleusa Coral Ghanem

    2000-04-01

    Full Text Available Objetivo: Estudar o comportamento e características de usuários de lentes de contato ligados à área de saúde. Método: Realizou-se um levantamento entre universitários da área de saúde da Pontifícia Universidade Católica do Paraná, em Curitiba, no período de 23 a 27 de novembro de 1998. Para a coleta de dados foi utilizado um questionário auto-aplicável, previamente testado. Resultados e Discussão: Dentre 1.173 estudantes, 207 (17,2% usavam lentes de contato, sendo 78,3% do sexo feminino e 21,7% do sexo masculino. Eram usuários de lentes rígidas 12,1% e 87,9% utilizavam hidrofílicas, demonstrando um aumento progressivo das últimas quando se compara a estudos nacionais anteriores. Dos usuários de lentes de contato hidrofílicas, 57,6% utilizavam descartáveis e desses 88,5% não as utilizavam de acordo com os padrões de uso e descartabilidade estabelecidos. Do número total de usuários, 37,7% relataram algum problema ocular durante o uso. Embora 97,1% tenham feito a adaptação com o oftalmologista, 14,2% dos usuários de descartáveis não obtiveram novas lentes em clínicas oftalmológicas. Por outro lado, 81,1% procuraram o oftalmologista, semestral ou anualmente, para a revisão da adaptação. Recomendação: Para reduzir o número de complicações e a desistência do uso de lentes de contato, o usuário deve ser educado sobre a forma correta de utilizá-las, ser orientado sobre os sinais e sintomas de alerta para problemas oculares e receber as informações também por escrito.Purpose: To study the behavior and characteristics of contact lens wearers involved in health areas. Methods: To conduct a survey among students of health related courses at the Pontifícia Universidade Católica do Paraná, in Curitiba, during the period from 23rd to 27th November 1998. A previously tested, self-applicable questionnaire was used to collect data. Results and Discussion: Among 1,173 students, 207 (17.2% used contact lenses, of

  5. Relação entre desempenho funcional de crianças com paralisia cerebral e qualidade de vida relacionada à saúde de seus cuidadores Relationship between functional performance of children with cerebral palsy and health-related quality of life of their caregivers

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    Ana Paula Rocha

    2008-09-01

    Full Text Available Cuidadores de crianças com paralisia cerebral (PC, ao lidar com as incapacidades da criança, são suscetíveis a detrimento de sua saúde física e bem-estar psicológico, o que pode ter impacto em sua qualidade de vida relacionada à saúde (QV. O objetivo deste estudo foi verificar se há correlação entre o desempenho funcional de crianças com PC e a QV de seus cuidadores, verificando também eventual correlação entre o nível de função motora e o desempenho funcional em crianças com PC. A QV de 17 cuidadores de crianças com PC foi avaliada pelo questionário Short-Form Health Survey (SF-36; a função motora e o desempenho funcional das respectivas crianças foram avaliados pelo Gross Motor Function Classification System (GMFCS e pelo Inventário de Avaliação Pediátrica de Disfunção (PEDI. Os dados foram tratados estatisticamente. Nenhuma correlação significativa foi encontrada entre a classificação no GMFCS ou o escore no PEDI e os escores dos cuidadores no SF-36. Foi encontrada forte correlação negativa entre os escores das crianças no PEDI e os níveis do GMFCS. A qualidade de vida de cuidadores de crianças com PC não foi pois influenciada pelo grau de limitação funcional de suas crianças. No entanto, o GMFCS mostrou-se um bom preditor de funcionalidade em crianças com paralisia cerebral.When dealing with the child's disabilities, caregivers of children with cerebral palsy (CP are likely to experience physical or psychological suffering, which may impact their health-related quality of life (QoL. This study searched for a correlation between CP children's functional performance and their caregivers' QoL, also looking for a correlation between gross motor functional level and functional performance in children with CP. The QoL of 17 caregivers of children with CP was assessed by the Short-Form Health Survey (SF-36; children's functional performance was evaluated by means of the Gross Motor Function

  6. Avaliação das práticas e conhecimentos de profissionais da atenção primária à saúde sobre vigilância do desenvolvimento infantil Evaluation of practices and knowledge among primary health care professionals in relation to child development surveillance

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    Amira Consuêlo de Melo Figueiras

    2003-12-01

    Full Text Available O objetivo desta pesquisa foi avaliar os conhecimentos e práticas relacionados à vigilância do desenvolvimento da criança de 160 profissionais que atuam na atenção primária à saúde, no Município de Belém, Pará. Foram selecionados 40 médicos e 40 enfermeiros de Unidades Municipais de Saúde (UMS, e 40 médicos e 40 enfermeiros do Programa da Família Saudável (PFS. Na avaliação dos conhecimentos por meio da aplicação de teste objetivo, o percentual de acerto foi de 63,7% para médicos das UMSs, 57,3% para médicos do PFS, 62,1% para os enfermeiros do PFS e 54,3% para enfermeiros das UMSs. Na avaliação das práticas, apenas 21,8% das mães informaram que foram indagadas sobre o desenvolvimento dos seus filhos, 27,6% que o profissional perguntou ou observou o desenvolvimento da sua criança e 14,4% que receberam orientação sobre como estimulá-las. Concluímos que médicos e enfermeiros da atenção primária no Município de Belém apresentam deficiências nos conhecimentos sobre desenvolvimento infantil e que a vigilância do desenvolvimento não é realizada de forma satisfatória, sendo necessárias sensibilização e capacitação dos profissionais para esta prática.In the present study, the practices and knowledge of 40 physicians and 40 nurses from municipal health care units (UMS and 40 physicians and 40 nurses from the Family Health Program (FHP in Belém, Pará State, Brazil, all of whom working in primary health care, were evaluated in relation to child development surveillance. Measures of knowledge of child development showed an average of 63.7% correct answers for UMS physicians, 57.3% for FHP physicians, 62.1% for FHP nurses, and 54.3% for UMS nurses. Only 21.8% of mothers attending appointments mentioned that the health care professional had asked about their children’s development, 27.6% of mothers reported that the health care professional had asked about or observed the child’s development, and 14

  7. Conceptual framework for research and clinical practice concerning cardiovascular health-related behaviors Modelo conceptual para la investigación y la práctica clínica en los cambios de comportamiento en salud cardiovascular Estrutura conceitual para pesquisa e prática clínica na mudança de comportamentos em saúde cardiovascular

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    Maria Cecília Bueno Jayme Gallani

    2013-02-01

    Full Text Available OBJECTIVE: To present a conceptual framework based on the PRECEDE model conceived to guide research and the clinical practice of nurses in the clinical follow-up of patients with cardiovascular diseases. METHOD: The conceptual bases as well as the study designs used in the framework are discussed. The contextualization of the proposed structure is presented in the clinical follow-up of hypertensive patients. Examples of the intervention planning steps according to the intervention mapping protocol are provided. RESULTS: This conceptual framework coherently and rationally guided the diagnostic steps related to excessive salt intake among hypertensive individuals, as well as the development and assessment of specific interventions designed to change this eating behavior. CONCLUSION: The use of this conceptual framework enables a greater understanding of health-related behaviors implied in the development and progression of cardiovascular risk factors and is useful in proposing nursing interventions with a greater chance of success. This model is a feasible strategy to improve the cardiovascular health of patients cared for by the Brazilian Unified Health System.OBJETIVO: presentar el marco conceptual basado en el modelo PRECEDE, concebido para orientar la investigación y la práctica clínica de las enfermeras para el seguimiento clínico de pacientes cardíacos. MÉTODO: La base conceptual, así como los diseños metodológicos de los estudios implicados en el marco conceptual son discutidos. Además, la contextualización del modelo se ilustra en el seguimiento clínico de los pacientes hipertensos. Ejemplos de las etapas de planificación de la intervención de acuerdo con el protocolo intervention mapping son proporcionados. RESULTADOS: Se observó que la utilización del marco conceptual permitió guiar coherentemente y racionalmente los pasos de diagnóstico relacionados con el consumo excesivo de sal entre hipertensos, así como el

  8. Onset of molar incisor hypomineralization (MIH).

    Science.gov (United States)

    Fagrell, Tobias G; Salmon, Phil; Melin, Lisa; Norén, Jörgen G

    2013-01-01

    The etiological factors and timing of the onset of molar incisor hypomineralization (MIH) are still not clear. The aim of this study was to examine ground radial and sagittal sections from teeth diagnosed with MIH using light microscopy, polarized light microscopy and X-ray micro-computed tomography (XMCT) and to estimate the onset and timing of the MIH and to relate the hypomineralized enamel to the incremental lines. Thirteen extracted permanent first molars diagnosed MIH, were analyzed with light microscopy and XMCT. The hypomineralized areas were mainly located in the mesio-buccal cusps, starting at the enamel-dentin-junction and continuing towards the enamel surface. In a relative gray scale analysis the values decreased from the EDJ towards the enamel surface. The findings indicate that the ameloblasts in the hypomineralized enamel are capable of forming an enamel of normal thickness, but with a substantial reduction of their capacity for maturation of enamel. Chronologically, it is estimated that the timing of the disturbance is at a period during the first 6-7 months of age.

  9. Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension.

    Science.gov (United States)

    Veerbeek, Jan H W; Hermes, Wietske; Breimer, Anath Y; van Rijn, Bas B; Koenen, Steven V; Mol, Ben W; Franx, Arie; de Groot, Christianne J M; Koster, Maria P H

    2015-03-01

    Observational studies have shown an increased lifetime risk of cardiovascular disease (CVD) in women who experienced a hypertensive disorder in pregnancy. This risk is related to the severity of the pregnancy-related hypertensive disease and gestational age at onset. However, it has not been investigated whether these differences in CVD risk factors are already present at postpartum cardiovascular screening. We evaluated postpartum differences in CVD risk factors in 3 subgroups of patients with a history of hypertensive pregnancy. We compared the prevalence of common CVD risk factors postpartum among 448 women with previous early-onset preeclampsia, 76 women with previous late-onset preeclampsia, and 224 women with previous pregnancy-induced hypertension. Women with previous early-onset preeclampsia were compared with women with late-onset preeclampsia and pregnancy-induced hypertension and had significantly higher fasting blood glucose (5.29 versus 4.80 and 4.83 mmol/L), insulin (9.12 versus 6.31 and 6.7 uIU/L), triglycerides (1.32 versus 1.02 and 0.97 mmol/L), and total cholesterol (5.14 versus 4.73 and 4.73 mmol/L). Almost half of the early-onset preeclampsia women had developed hypertension, as opposed to 39% and 25% of women in the pregnancy-induced hypertension and late-onset preeclampsia groups, respectively. Our data show differences in the prevalence of common modifiable CVD risk factors postpartum and suggest that prevention strategies should be stratified according to severity and gestational age of onset for the hypertensive disorders of pregnancy.

  10. Biodiversidade, biotecnologia e saúde

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    Garcia Eloi S.

    1995-01-01

    Full Text Available Este artigo apresenta a importância da biodiversidade, da biotecnologia a da saúde e discute vários aspectos dos problemas biológicos, ambientais e o dilema ético, relacionados com a expansão e a exploração dos recursos naturais em razão das quais espécies de plantas e animais têm sido extintas. Por outro lado, o conhecimento da biodiversidade tem possibilitado a identificação e a utilização de novos recursos naturais para a melhoria da vida do homem neste planeta. É importante que nossos pesquisadores se envolvam na luta pela preservação do ecossistema tropical. Os programas de exploração da biodiversidade devem estar baseados em sólidos conhecimentos científicos e favorecer ecológica e economicamente a sociedade.

  11. Biodiversidade, biotecnologia e saúde

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    Eloi S. Garcia

    1995-09-01

    Full Text Available Este artigo apresenta a importância da biodiversidade, da biotecnologia a da saúde e discute vários aspectos dos problemas biológicos, ambientais e o dilema ético, relacionados com a expansão e a exploração dos recursos naturais em razão das quais espécies de plantas e animais têm sido extintas. Por outro lado, o conhecimento da biodiversidade tem possibilitado a identificação e a utilização de novos recursos naturais para a melhoria da vida do homem neste planeta. É importante que nossos pesquisadores se envolvam na luta pela preservação do ecossistema tropical. Os programas de exploração da biodiversidade devem estar baseados em sólidos conhecimentos científicos e favorecer ecológica e economicamente a sociedade.

  12. Novas Tecnologias e Saúde

    OpenAIRE

    2013-01-01

    Introdução Comecemos por algo simples: lidar e combater doenças sempre pressupõe alguma forma de domínio técnico, mesmo quando as práticas para obtenção da saúde estão culturalmente associadas a meios mágicos. Um aspecto importante da magia, seu sentido ritualístico estrito, a observância de fórmulas rigorosas, constitui uma forma de racionalização da experiência empírica, que resulta em conhecimento sobre propriedades alucinógenas ou curativas de certos vegetais, por exemplo. A esse resp...

  13. Mortality Risks in New-Onset Childhood Epilepsy

    NARCIS (Netherlands)

    Berg, Anne T.; Nickels, Katherine; Wirrell, Elaine C.; Geerts, Ada T.; Callenbach, Petra M. C.; Arts, Willem F.; Rios, Christina; Camfield, Peter R.; Camfield, Carol S.

    OBJECTIVES: Estimate the causes and risk of death, specifically seizure related, in children followed from onset of epilepsy and to contrast the risk of seizure-related death with other common causes of death in the population. METHODS: Mortality experiences from 4 pediatric cohorts of newly

  14. Mortality Risks in New-Onset Childhood Epilepsy

    NARCIS (Netherlands)

    Berg, Anne T.; Nickels, Katherine; Wirrell, Elaine C.; Geerts, Ada T.; Callenbach, Petra M. C.; Arts, Willem F.; Rios, Christina; Camfield, Peter R.; Camfield, Carol S.

    2013-01-01

    OBJECTIVES: Estimate the causes and risk of death, specifically seizure related, in children followed from onset of epilepsy and to contrast the risk of seizure-related death with other common causes of death in the population. METHODS: Mortality experiences from 4 pediatric cohorts of newly diagnos

  15. Genetics Home Reference: early-onset glaucoma

    Science.gov (United States)

    ... Home Health Conditions early-onset glaucoma early-onset glaucoma Enable Javascript to view the expand/collapse boxes. Download PDF Open All Close All Description Glaucoma is a group of eye disorders in which ...

  16. Saúde oral: um desafio para a equipe de saúde

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    Vera Lúcia de Oliveira Gomes

    2001-03-01

    Full Text Available Esta pesquisa teve como objetivo desvelar o conhecimento dos formandos dos cursos de Enfermagem e Medicina de uma Universidade do Rio Grande do Sul acerca da promoção da Saúde Oral. Participaram do estudo 58 acadêmicos, sendo 26 do Curso de Enfermagem e 32 do Curso de Medicina, estes responderam a um questionário com três perguntas semi-estruturadas. Através da triangulação constatamos que esse conhecimento entre os formandos dos referidos cursos é deficitário. Sabemos que é grande a dificuldade de acesso da população infantil carente aos gabinetes dentários, por esse motivo, acreditamos ser indispensável que os profissionais de Enfermagem e Medicina tenham conhecimentos referentes à promoção de saúde oral em crianças.

  17. Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin

    NARCIS (Netherlands)

    Vossenaar, E.R.; Despres, N.; Lapointe, E.; Heijden, A.G. van der; Lora, M.; Senshu, T.; Venrooij, W.J.W. van; Menard, H.A.

    2004-01-01

    Antibodies directed to the Sa antigen are highly specific for rheumatoid arthritis ( RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it has been stated that the Sa antigen is

  18. Late onset hereditary episodic ataxia.

    Science.gov (United States)

    Damak, M; Riant, F; Boukobza, M; Tournier-Lasserve, E; Bousser, M-G; Vahedi, K

    2009-05-01

    Episodic ataxias (EA) are hereditary paroxysmal neurological diseases with considerable clinical and genetic heterogeneity. So far seven loci have been reported and four different genes have been identified. Analysis of additional sporadic or familial cases is needed to better delineate the clinical and genetic spectrum of EA. A two generation French family with late onset episodic ataxia was examined. All consenting family members had a brain MRI with volumetric analysis of the cerebellum. Haplotype analysis was performed for the EA2 locus (19p13), the EA5 locus (2q22), the EA6 locus (5p13) and the EA7 locus (19q13). Mutation screening was performed for all exons of CACNA1A (EA2), EAAT1 (EA6) and the coding sequence of KCNA1 (EA1). Four family members had episodic ataxia with onset between 48 and 56 years of age but with heterogeneity in the severity and duration of symptoms. The two most severely affected had daily attacks of EA with a slowly progressive and disabling permanent cerebellar ataxia and a poor response to acetazolamide. Brain MRI showed in three affected members a decrease in the ratio of cerebellar volume:total intracranial volume, indicating cerebellar atrophy. No deleterious mutation was found in CACNA1A, SCA6, EAAT1 or KCNA1. In addition, the EA5 locus was excluded. A new phenotype of episodic ataxia has been described, characterised clinically by a late onset and progressive permanent cerebellar signs, and genetically by exclusion of the genes so far identified in EA.

  19. Fatores relacionados ao diagnóstico de enfermagem autocontrole ineficaz da saúde entre diabéticos Factores relacionados al diagnóstico de enfermería autocontrol ineficaz de la salud entre diabéticos Factors related to nursing diagnosis, ineffective self-health management, among diabetics

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    Roberto Wagner Júnior Freire de Freitas

    2011-01-01

    Full Text Available OBJETIVO: Investigar os fatores relacionados ao diagnóstico de enfermagem autocontrole ineficaz da saúde em usuários, de serviço de atenção básica à saúde, com Diabetes mellitus tipo 2, tratados com antidiabéticos orais (AO, segundo o sexo. MÉTODOS: Estudo de análise secundária de um banco de dados de pesquisa realizada, entre janeiro e julho de 2009, nos domicílios de 377 usuários de 12 centros de saúde da família de Fortaleza-CE. Para determinar a presença do diagnóstico de enfermagem foi realizada uma analogia entre as questões do teste Medida de Adesão ao Tratamento e quatro das cinco características definidoras do diagnóstico pesquisado. RESULTADOS: Os homens tinham um sentimento de impotência maior (30,4% que as mulheres (18,4% acerca da tomada dos AO (p=0,034. As mulheres conseguiram perceber melhor os benefícios da tomada correta dos AO no controle do Diabetes (p=0,002. CONCLUSÃO: Fatores de caráter socioeconômico importantes no controle da doença como a demanda excessiva e deficit de apoio social foram predominantes e significativos entre os homens.OBJETIVO: Investigar los factores relacionados al diagnóstico de enfermería autocontrol ineficaz de la salud en usuarios, del servicio de atención básica a la salud, con Diabetes mellitus tipo 2, tratados con antidiabéticos orales (AO, según el sexo. MÉTODOS: Estudio de análisis secundario de un banco de datos de investigación realizada, entre enero y julio del 2009, en los domicilios de 377 usuarios de 12 centros de salud de la familia de Fortaleza-CE. Para determinar la presencia del diagnóstico de enfermería fue realizada una analogía entre las preguntas del test Medida de Adhesión al Tratamiento y cuatro de las cinco características definidoras del diagnóstico investigado. RESULTADOS: los hombres tenían un sentimiento de impotencia mayor (30,4% que el de las mujeres (18,4% respecto a la toma de los AO (p=0,034. Las mujeres consiguieron percibir

  20. Efeito de um mês de destreinamento sobre a aptidão física relacionada à saúde em programa de mudança de estilo de vida Effects of one month detraining over health-related physical fitness in a lifestyle change program

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    Edilaine Michelin

    2008-06-01

    the present study was to evaluate the effect of detraining on physical fitness related to health. Forty-four healthy subjects, both male and female, aged 57.6±8.9 years performed the ‘Mexa-se Pró-Saúde’ protocol with nutritional orientation and supervised physical exercises for nine months. The program consisted of aerobic, localized muscular endurance and flexibility exercises, with duration 80 minutes/session, five days/week. Only subjects who participated in the program for more than three days/week have been selected. The detraining period was one month. Weight (kg and height (m were measured and the body mass index (BMI calculated. Additionally, motors tests to evaluate the flexibility (FLEX, strength of lower limbs (SLL and upper limbs (SUL, and maximal oxygen uptake (VO2máx were conducted in the beginning of the study (MI, after nine months of practicing (MT and after detraining period (MD. ANOVA (p<0.05 and Tukey test to show the difference between groups when it evidence were used for statistical treatment. The results showed that the gains of 22% and 7% on SLL and VO2máx respectively, obtained with the training, have not changed during the detraining period; however, the flexibility gain of 8% returned back to baseline after the detraining period. BMI and SUL did not change during the study. Although the lower limbs strength gains and maximal oxygen uptake obtained have been kept, one month of detraining was enough for losing the flexibility acquired.

  1. Projetos PET-Saúde e Educando para a Saúde: construindo saberes e práticas

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    Pâmela Leites de Souza

    Full Text Available Buscando alcançar ações intersetoriais efetivas e inovadoras, o projeto Educando para a Saúde, vem envolvendo as escolas, academia e serviços de saúde locais no desafio de construir uma sólida relação entre saúde-escola. O presente relato de experiência socializa a trajetória do projeto Educando para a Saúde, uma parceria entre a Equipe de Saúde da Família (ESF de um bairro de Pelotas - RS, a comunidade docente de duas escolas do território e acadêmicos do Programa de Educação pelo Trabalho para a Saúde - PET-Saúde. O objetivo é refletir o papel da ESF e dos acadêmicos do Projeto PET-Saúde na integração saúde-educação. Os temas discutidos são relacionados à educação em sexualidade, direitos sexuais e reprodutivos com ênfase nas DSTs e métodos contraceptivos, prevenção, promoção e recuperação da saúde. A participação do acadêmico nas atividades de integração saúde-educação veio a acrescentar ideias, valores e conceitos, possibilitando a (reconstrução das relações interpessoais, promovendo a reciclagem do processo de trabalho. Pelos laços multiprofissionais e interdisciplinares, essa parceria consiste em aprendizado mútuo, cujos frutos refletem diretamente na melhoria da assistência prestada à comunidade.

  2. [Late-onset dysthymic states].

    Science.gov (United States)

    Siranchiev, M A

    2002-01-01

    Sixty patients with dysthymic states which had emerged in later age of 60-80 years were examined. Two clinical types of dysthymic states were described: anergic (20 patients) and hypothymic (40 patients). Different comorbid mental disorders--obsessive-phobic (14 cases), somatoform (10), personality deviations (20) and psycho-organic (7)--were found to be characteristic of late-onset dysthymic states. According to developmental features, late dysthymia was primary (first manifested in the elderly) and secondary (develops after several depressive episodes). In diagnostic terms, the former is considered as "dysthymia" (F34.1 ICD-10) and the latter--as "recurrent depressive disorder" (F33).

  3. Gasto privado com saúde por classes de renda

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    KILSZTAJN SAMUEL

    2002-01-01

    Full Text Available OBJETIVO: O artigo analisa a participação do gasto privado com saúde das famílias no PIB e no total da renda familiar per capita e a distribuição do gasto privado com saúde das famílias por classes de renda. MÉTODOS: A pesquisa utilizou os microdados da Pesquisa Nacional por Amostra de Domicílios de 1998, com a divisão da população em quatro classes de renda familiar per capita e a distribuição dos gastos em planos de saúde, consultas médicas, consultas com outros profissionais de saúde, exames, medicamentos, artigos ortopédicos e aparelhos médicos, óculos e lentes, odontologia, hospitais, enfermagem domiciliar e outros gastos com saúde. RESULTADOS: Apenas 7,2% da população com renda familiar per capita até 1 salário mínimo em 1998 tinha direito a algum plano de saúde, e o gasto privado com saúde das famílias desta classe, que representava 52,5% da população, era em média de R$ 5,36 por pessoa. Para as pessoas com renda familiar per capita acima de 9 salários mínimos, os planos de saúde atingiam 83,2% da população e o gasto privado com saúde das famílias R$ 133,04. CONCLUSÕES: A implantação do Sistema Único de Saúde foi acompanhada pelo crescimento expressivo dos planos de saúde nos anos 90. Mesmo se todo o gasto público com saúde fosse destinado à população sem planos de saúde, ainda assim o gasto destas pessoas em 1998 só alcançaria R$ 352,62, ou seja, 43% do gasto com saúde das pessoas com planos, R$ 819,08.

  4. Cardiovascular Disease Risk Factors After Early-Onset Preeclampsia, Late-Onset Preeclampsia, and Pregnancy-Induced Hypertension

    NARCIS (Netherlands)

    Veerbeek, Jan H. W.; Hermes, Wietske; Breimer, Anath Y.; van Rijn, Bas B.; Koenen, Steven V.; Mol, Ben W.; Franx, Arie; de Groot, Christianne J. M.; Koster, Maria P. H.; Koster, M.P.H. (Wendy)

    2015-01-01

    Observational studies have shown an increased lifetime risk of cardiovascular disease (CVD) in women who experienced a hypertensive disorder in pregnancy. This risk is related to the severity of the pregnancy-related hypertensive disease and gestational age at onset. However, it has not been investi

  5. Saúde mental e trabalho: os problemas que persistem

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    Leny Sato

    Full Text Available Este artigo toma por objeto a Saúde Mental e Trabalho como uma subárea do campo da Saúde do Trabalhador. Parte da constatação de que os problemas de saúde mental e trabalho, já identificados em meados da década de 1980, persistem. Após retomar a taxonomia de tais problemas, busca evidenciar algumas de suas expressões atuais a partir da assistência e da vigilância em saúde do trabalhador, bem como pela perspectiva de alguns sindicatos mais atentos à questão. Para tal, toma como ponto de partida o Centro de Referência em Saúde do Trabalhador (CRST de Campinas. Por fim, pontua algumas características do trabalho no contexto atual para compreender as motivações dessa persistência.

  6. Myopia onset and role of peripheral refraction

    Directory of Open Access Journals (Sweden)

    Rotolo M

    2017-06-01

    Full Text Available Maurilia Rotolo,1,2 Giancarlo Montani,2 Raul Martin1,3 1Optometry Research Group, IOBA Eye Institute, School of Optometry, Universidad de Valladolid, Valladolid, Spain; 2Optics and Optometry, Corso di Ottica e Optometria, Universita del Salento, Lecce, Italy; 3Faculty of Health and Human Sciences, School of Health Professions, Plymouth University, Peninsula Allied Health Centre, Plymouth, UK Background: To determine the peripheral refraction characteristics related to 18-month changes in refraction in Caucasian (Mediterranean children.Methods: Non-cycloplegic peripheral refraction at 10° intervals over the central ±30° of horizontal visual field over 18 months (baseline, 12 months, and 18 months of follow-up was conducted in 50 healthy children who were 8 years old. Axial length (AL was also recorded. Relative peripheral refraction (RPR was calculated and eyes were divided into three study groups: non-myopic eyes, myopic eyes, and eyes that develop myopia.Results: Myopic eyes showed hyperopic RPR and emetropic and hyperopic eyes showed myopic RPR. Univariate analysis of variance did not find any statistically significant effect of peripheral refraction (F36=0.13; P=1.00 and RPR (F36=0.79; P=0.80 on myopia onset (eyes that developed myopia along the study. All the studied groups showed an increase of AL, without statistically significant differences between the studied groups (F6=0.09; P=0.99.Conclusion: Hyperopic relative peripheral shift change in eyes that develop myopia has been found with differences in RPR between myopic (hyperopic RPR and hyperopic or emmetropic eyes (with myopic RPR. The results suggest that RPR cannot predict development or progression of myopia in Caucasian (Mediterranean children and the efficacy in slowing myopia progression obtained with treatments that manipulate the peripheral refraction is not just driven with RPR. Keywords: myopia, refractive errors, myopia onset, peripheral refraction, relative peripheral

  7. Em busca de uma Teologia Pública da Saúde

    Directory of Open Access Journals (Sweden)

    Alex Villas Boas

    2016-03-01

    Full Text Available A proposta de uma teologia pública da saúde visa o diálogo entre antropologia teológica e antropologias médicas e da saúde de modo a ampliar a percepção da saúde, não somente como fato, mas como valor. Mesmo um Estado Laico, suas tradições religiosas possuem hermenêuticas de saúde, ao interpretar a doença e a morte com razões religiosas distintas, ora conflitantes, ora cooperativas com as ciências da saúde. Ampliar essas hermenêuticas religiosas compondo a sabedoria de vida presente nas expressões religiosas e o conhecimento científico da área de saúde visa uma cooperação para interesses de bem comum da sociedade civil, como é a questão da saúde. Para essa reflexão, a escola de Cós combina a sabedoria mítica asclepíade e a ciência jônia. Os mitos de saúde nomeados no juramento hipocrático pertencem à tradição da teologia poética grega e indica uma espécie de credo no qual a medicina hipocrática professa, no qual o médico além de profissional também possui fé na vida e exerce o ofício de sacerdote da esperança. Interessa ainda o modo como o a teologia da saúde grega foi recebida pela teologia cristã, e como ambas desconstruíram suas teodiceias. Nessa recepção há um caminho para pensar uma teologia pública da saúde. 

  8. Early- versus Late-Onset Systemic Sclerosis

    Science.gov (United States)

    Alba, Marco A.; Velasco, César; Simeón, Carmen Pilar; Fonollosa, Vicent; Trapiella, Luis; Egurbide, María Victoria; Sáez, Luis; Castillo, María Jesús; Callejas, José Luis; Camps, María Teresa; Tolosa, Carles; Ríos, Juan José; Freire, Mayka; Vargas, José Antonio; Espinosa, Gerard

    2014-01-01

    Abstract Peak age at onset of systemic sclerosis (SSc) is between 20 and 50 years, although SSc is also described in both young and elderly patients. We conducted the present study to determine if age at disease onset modulates the clinical characteristics and outcome of SSc patients. The Spanish Scleroderma Study Group recruited 1037 patients with a mean follow-up of 5.2 ± 6.8 years. Based on the mean ± 1 standard deviation (SD) of age at disease onset (45 ± 15 yr) of the whole series, patients were classified into 3 groups: age ≤30 years (early onset), age between 31 and 59 years (standard onset), and age ≥60 years (late onset). We compared initial and cumulative manifestations, immunologic features, and death rates. The early-onset group included 195 patients; standard-onset group, 651; and late-onset, 191 patients. The early-onset group had a higher prevalence of esophageal involvement (72% in early-onset compared with 67% in standard-onset and 56% in late-onset; p = 0.004), and myositis (11%, 7.2%, and 2.9%, respectively; p = 0.009), but a lower prevalence of centromere antibodies (33%, 46%, and 47%, respectively; p = 0.007). In contrast, late-onset SSc was characterized by a lower prevalence of digital ulcers (54%, 41%, and 34%, respectively; p < 0.001) but higher rates of heart conduction system abnormalities (9%, 13%, and 21%, respectively; p = 0.004). Pulmonary hypertension was found in 25% of elderly patients and in 12% of the youngest patients (p = 0.010). After correction for the population effects of age and sex, standardized mortality ratio was shown to be higher in younger patients. The results of the present study confirm that age at disease onset is associated with differences in clinical presentation and outcome in SSc patients. PMID:24646463

  9. SpringSaLaD: A Spatial, Particle-Based Biochemical Simulation Platform with Excluded Volume.

    Science.gov (United States)

    Michalski, Paul J; Loew, Leslie M

    2016-02-02

    We introduce Springs, Sites, and Langevin Dynamics (SpringSaLaD), a comprehensive software platform for spatial, stochastic, particle-based modeling of biochemical systems. SpringSaLaD models biomolecules in a coarse-grained manner as a group of linked spherical sites with excluded volume. This mesoscopic approach bridges the gap between highly detailed molecular dynamics simulations and the various methods used to study network kinetics and diffusion at the cellular level. SpringSaLaD is a standalone tool that supports model building, simulation, visualization, and data analysis, all through a user-friendly graphical user interface that should make it more accessible than tools built into more comprehensive molecular dynamics infrastructures. Importantly, for bimolecular reactions we derive an exact expression relating the macroscopic on-rate to the various microscopic parameters with the inclusion of excluded volume; this makes SpringSaLaD more accurate than other tools, which rely on approximate relationships between these parameters.

  10. A cross-sectional study of oral health-related quality of life of Piracicaba’s elderly population = Qualidade de vida pela saúde bucal em uma população de idosos do município de Piracicaba: um estudo transversal

    Directory of Open Access Journals (Sweden)

    Alcarde, Anabel Cristina Bortoletto

    2010-01-01

    Full Text Available Objetivo: Este trabalho objetivou medir a auto-percepção nas condições de saúde bucal de 137 idosos do município de Piracicaba, São Paulo, Brasil; considerando a influência de variáveis sociodemográficas, situação de institucionalização, e acesso aos serviços de saúde bucal sobre a pontuação final do índice GOHAI. Metodologia: A amostra deste estudo foi composta por idosos institucionalizados e não institucionalizados, com idade variando de 60 a 92 anos de idade, socialmente independente ou parcialmente dependente, sem alterações cognitivas significantes, com diferentes níveis educacionais e renda mensal. Exame oral e dois questionários foram utilizados para coletar informações necessárias sobre os sujeitos da pesquisa: um primeiro composto pelos 12 itens do índice GOHAI, e um segundo para análise das variáveis sociodemográficas. Os dados foram tratados pelo teste do Qui-Quadrado e Regressão Logística, considerando P<0,05. Resultados: A média final do índice GOHAI foi de 27,49 denotando um baixo nível de auto-percepção, e uma associação estatisticamente significante para as variáveis estilo de vida e institucionalização. Foi considerado fator de risco para baixa auto-percepção da saúde bucal a demanda urgente por assistência odontológica e a necessidade sentida pelo paciente para assistência odontológica, resultando em um baixo índice GOHAI, com diferença estatisticamente significante (P<0,0001, provando que uma baixa auto-percepção da saúde bucal tem correlação direta com uma pior condição clínica de saúde bucal, podendo ser utilizado para planejamento em saúde pública. Conclusão: A pontuação final do índice GOHAI neste estudo é considerada baixa. Auto-motivação e auto-percepção para necessidade de assistência odontológica foram considerados indicadores de risco para uma baixa pontuação do índice GOHAI

  11. Time to diagnosis in young-onset dementia as compared with late-onset dementia

    NARCIS (Netherlands)

    Vliet, D. van; Vugt, M.E. de; Bakker, C.; Pijnenburg, Y.A.; Vernooij-Dassen, M.J.F.J.; Koopmans, R.T.C.M.; Verhey, F.R.J.

    2013-01-01

    BACKGROUND: The extent to which specific factors influence diagnostic delays in dementia is unclear. Therefore, the aim of the present study was to compare duration from symptom onset to diagnosis for young-onset dementia (YOD) and late-onset dementia (LOD) and to assess the effect of age at onset,

  12. Adult-onset mitochondrial myopathy.

    Science.gov (United States)

    Fernandez-Sola, J.; Casademont, J.; Grau, J. M.; Graus, F.; Cardellach, F.; Pedrol, E.; Urbano-Marquez, A.

    1992-01-01

    Mitochondrial diseases are polymorphic entities which may affect many organs and systems. Skeletal muscle involvement is frequent in the context of systemic mitochondrial disease, but adult-onset pure mitochondrial myopathy appears to be rare. We report 3 patients with progressive skeletal mitochondrial myopathy starting in adult age. In all cases, the proximal myopathy was the only clinical feature. Mitochondrial pathology was confirmed by evidence of ragged-red fibres in muscle histochemistry, an abnormal mitochondrial morphology in electron microscopy and by exclusion of other underlying diseases. No deletions of mitochondrial DNA were found. We emphasize the need to look for a mitochondrial disorder in some non-specific myopathies starting in adult life. Images Figure 1 Figure 2 PMID:1589382

  13. Safety of Tirofiban in acute Ischemic Stroke: the SaTIS trial.

    Science.gov (United States)

    Siebler, Mario; Hennerici, Michael G; Schneider, Dietmar; von Reutern, Gerhard M; Seitz, Rüdiger J; Röther, Joachim; Witte, Otto W; Hamann, Gerhard; Junghans, Ulrich; Villringer, Arno; Fiebach, Jochen B

    2011-09-01

    Tirofiban is a highly selective, fast-acting nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist with a short half-life time. Glycoprotein IIb/IIIa antagonists are effective for the treatment of acute coronary syndromes proven in large clinical trials. Safety and efficacy in patients with ischemic stroke are uncertain. This was addressed in the Safety of Tirofiban in acute Ischemic Stroke (SaTIS) trial. Two hundred sixty patients with acute ischemic stroke were randomized in a placebo-controlled, prospective, open-label treatment, blinded outcome reading multicenter trial. Subjects with a National Institutes of Health Stroke Scale between 4 and 18 received intravenously either tirofiban or placebo within 3 to 22 hours after symptom onset for 48 hours. The primary end point was the rate of cerebral bleeding as measured in follow-up CT scans 2 to 7 days after inclusion. The secondary end point was clinical efficacy within 1 week (National Institutes of Health Stroke Scale, modified Rankin Scale) and after 5 months (Barthel Index, modified Rankin Scale). The rate of cerebral hemorrhagic transformation (I/II) and parenchymal hemorrhage (I/II) did not differ between both groups (tirofiban 36 of 120; placebo 33 of 124: OR, 1.18; 95% CI, 0.66 to 2.06). Mortality after 5 months was significantly lower in patients treated with tirofiban (3 of 130 [2.3%] versus 11 of 126 [8.7%]; OR, 4.05; 95% CI, 1.1 to 14.9). No difference in neurological/functional outcome was found after 1 week and after 5 months. We conclude that tirofiban might be safe in acute moderate ischemic stroke even when administered within a large time window after symptom onset and might save lives in the late outcome. Clinical Trial Registration- URL: www.strokecenter.org/trials/. Trial name: SaTIS. Enrollment began before July 1, 2005.

  14. On SA, CA, and GA numbers

    CERN Document Server

    Caveney, Geoffrey; Sondow, Jonathan

    2011-01-01

    Gronwall's function $G$ is defined for $n>1$ by $G(n)=\\frac{\\sigma(n)}{n \\log\\log n}$ where $\\sigma(n)$ is the sum of the divisors of $n$. We call an integer $N>1$ a \\emph{GA1 number} if $N$ is composite and $G(N) \\ge G(N/p)$ for all prime factors $p$ of $N$. We say that $N$ is a \\emph{GA2 number} if $G(N) \\ge G(aN)$ for all multiples $aN$ of $N$. In arXiv 1110.5078, we used Robin's and Gronwall's theorems on $G$ to prove that the Riemann Hypothesis (RH) is true if and only if 4 is the only number that is both GA1 and GA2. Here, we study GA1 numbers and GA2 numbers separately. We compare them with superabundant (SA) and colossally abundant (CA) numbers (first studied by Ramanujan). We give algorithms for computing GA1 numbers; the smallest one with more than two prime factors is 183783600, while the smallest odd one is 1058462574572984015114271643676625. We find nineteen GA2 numbers $\\le 5040$, and prove that a GA2 number $N>5040$ exists if and only if RH is false, in which case $N$ is even and $>10^{8576}$.

  15. Triagem em saúde mental infantil

    Directory of Open Access Journals (Sweden)

    Fabiana Vieira Gauy

    Full Text Available Este estudo foi conduzido para comparar os resultados de um procedimento grupal aberto e um procedimento individual estruturado para avaliação do comportamento da criança conforme o relato materno. Participaram deste estudo 29 mães que buscavam atendimento para seus filhos em uma unidade de saúde mental infanto-juvenil. As primeiras 15 mães que procuraram o serviço foram entrevistadas individualmente conforme um roteiro estruturado desenvolvido a partir do CBCL e depois foram entrevistadas em grupo, em formato aberto. As outras 14 mães participaram da entrevista grupal aberta e em seguida participaram da entrevista individual estruturada. Os resultados das entrevistas foram comparados tomando como referência as 67 categorias comportamentais identificadas a partir do roteiro individual e quatro variáveis contextuais relatadas nos dois procedimentos. Os resultados mostram que um número substancialmente maior de comportamentos-problema foi identificado através de entrevista individual estruturada do que através de entrevista grupal aberta realizada com os mesmos informantes. É possível que o uso de um roteiro estruturado em entrevistas grupais possa oferecer mais informações com otimização do tempo de avaliação.

  16. The onset of human parturition.

    Science.gov (United States)

    Kamel, Remah Moustafa

    2010-06-01

    Despite impressive progress in the science and technology of reproduction, the mechanism by which labour is initiated in humans remains obscure. As the labour in humans is a distinct event differs from what happens in animals, this study aims to gather the current theories that could explain when and why the onset of human parturition occurs. In a comprehensive review study done at the School of Medicine and Dentistry, University of Bristol, United Kingdom, MetaLib, the university web-based electronic library, was cross-searched for the factors behind the onset of labour in humans through different medical databases such as; Allied and Complementary Medicine Database (AMED), BIOSIS Previews on Web of Knowledge, PubMed, Cochrane Library, Medline and Web of Science, in-addition to the relevant printed medical journals and periodicals. The study revealed that among the potential factors involved in the process of human parturition are the changes in hormonal levels of estrogen and progesterone, increased production of prostaglandins and oxytocin, and the high levels of corticotrophin releasing hormone and cortisol are some among the potential factors involved in the process of human parturition. Inflammatory reactions with the release of cytokines are among the most accepted theories for term and preterm labours. It is most likely that the interaction between all these factors and others, yet to be discovered, play in harmony to initiate the process of labour in women. The result show that birth is a result of complex, partially defined, events that are tightly regulated by a variety of mechanisms and mediators of endocrine, nervous and immune systems. Unfortunately, none of them is completely elucidated.

  17. Development of a linear motion antenna for the JT-60SA ECRF system

    Energy Technology Data Exchange (ETDEWEB)

    Moriyama, Shinichi, E-mail: moriyama.shinichi@jaea.go.jp [Fusion Research and Development Directorate, Japan Atomic Energy Agency, Mukoyama 801-1, Naka, Ibaraki 311-0193 (Japan); Kobayashi, Takayuki; Isayama, Akihiko; Hoshino, Katsumichi; Suzuki, Sadaaki; Hiranai, Shinichi; Yokokura, Kenji; Sawahata, Masayuki; Terakado, Masayuki; Hinata, Jun; Wada, Kenji; Sato, Yoshikatsu [Fusion Research and Development Directorate, Japan Atomic Energy Agency, Mukoyama 801-1, Naka, Ibaraki 311-0193 (Japan)

    2013-10-15

    Highlights: ► Development of an antenna featuring linear motion (LM) concept for long pulse electron cyclotron range of frequency (ECRF) heating and current drive in JT-60SA is in progress. ► A mock-up using a metallic sliding bearing with solid lubricant was fabricated. ► A vacuum pumping test with mass analyzer showed evidence of some hydrocarbons during shaft motion. ► Injection beam profile in toroidal beam scan was checked by low power measurement with mock-up. ► Current drive characteristics with the LM antenna for typical experimental scenarios of JT-60SA have been investigated by calculation. -- Abstract: Development of an antenna that features the linear motion (LM) concept for long-pulse electron-cyclotron range of frequency heating and current drive for the JT-60SA is in progress. Combining a linearly movable first mirror and a fixed curved second mirror allows the injection-beam angle to be controlled. Cooling water is fed through the drive shaft for the first mirror and through the fixed support for the second mirror. The shaft support structure uses a metallic sliding bearing with a solid lubricant. The sliding bearing supports combined linear and rotational motion, whereas a conventional ball bearing supports either linear or rotational motion. Therefore, the sliding bearing offers the advantage of reducing the support-structure volume, which is important in the design of the relatively narrow port duct of the JT-60SA. Recently, the sliding bearing has been installed into the mockup. Results of a vacuum test with a mass analyzer indicate the presence of hydrocarbons during shaft motion. The injection-beam profile obtained from a toroidal beam scan is checked against low-power measurements taken on the mockup. Finally, for typical JT-60SA experimental scenarios, heating- and current-drive characteristics of the LM antenna are investigated theoretically.

  18. Narrativas na formação comum de profissionais de saúde

    Directory of Open Access Journals (Sweden)

    Angela Aparecida Capozzolo

    Full Text Available Este texto relata a experiência de formação comum que ocorre desde 2007 no campus Baixada Santista da Universidade Federal de São Paulo, no terceiro semestre de graduação, do eixo curricular trabalho em saúde. A experiência articula estudantes e docentes de diferentes áreas profissionais: educação física, fisioterapia, nutrição, psicologia e terapia ocupacional. São apresentadas as diretrizes e estratégias de organização do módulo 'Prática clínica integrada: análise de demandas e necessidades de saúde', que adota a produção de narrativas de histórias de vida e de questões de saúde de pessoas selecionadas por docentes em conjunto com as equipes da rede de serviços do município de Santos, São Paulo. As narrativas foram produzidas em encontros quinzenais dos estudantes com as pessoas acompanhadas em suas residências e de supervisões com os docentes. Realizouse análise de conteúdo de 120 relatórios de conclusão do módulo elaborados pelos estudantes nos anos de 2007 e 2008 visando identificar efeitos dessa proposta de formação. A elaboração de narrativas favoreceu aos estudantes ampliar a capacidade de escuta e a percepção da complexidade do processo saúdedoençacuidado, bem como de outros aspectos do que se tem denominado de 'clínica comum' às diversas profissões em saúde.

  19. Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction.

    Science.gov (United States)

    Amil-Ruiz, Francisco; Garrido-Gala, José; Gadea, José; Blanco-Portales, Rosario; Muñoz-Mérida, Antonio; Trelles, Oswaldo; de Los Santos, Berta; Arroyo, Francisco T; Aguado-Puig, Ana; Romero, Fernando; Mercado, José-Ángel; Pliego-Alfaro, Fernando; Muñoz-Blanco, Juan; Caballero, José L

    2016-01-01

    Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.

  20. Partial activation of SA- and JA-defensive pathways in strawberry upon Colletotrichum acutatum interaction

    Directory of Open Access Journals (Sweden)

    FRANCISCO AMIL-RUIZ

    2016-07-01

    Full Text Available Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5 and FaPR10 were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.

  1. Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction

    Science.gov (United States)

    Amil-Ruiz, Francisco; Garrido-Gala, José; Gadea, José; Blanco-Portales, Rosario; Muñoz-Mérida, Antonio; Trelles, Oswaldo; de los Santos, Berta; Arroyo, Francisco T.; Aguado-Puig, Ana; Romero, Fernando; Mercado, José-Ángel; Pliego-Alfaro, Fernando; Muñoz-Blanco, Juan; Caballero, José L.

    2016-01-01

    Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen. PMID:27471515

  2. Antihypertensive medication postpones the onset of glaucoma

    DEFF Research Database (Denmark)

    Horwitz, Anna; Klemp, Marc; Jeppesen, Jørgen

    2017-01-01

    The aim was to investigate the impact of antihypertensive medication on the onset of glaucoma. Data from the complete Danish population between 40 and 95 years of age were used in the period from 1996 to 2012, covering >2.6 million individuals. The National Danish Registry of Medicinal Products...... Statistics was used to identify all claimed prescriptions for glaucoma medication and antihypertensive drugs. We first investigated basic correlations in the data and found that patients treated with antihypertensive medication, at any time during the study period, had a significantly higher overall relative...... a regression discontinuity study design. This analysis provides our main finding, namely that prescription of antihypertensive medication leads to a significant reduction in the risk of developing glaucoma. Therefore, although hypertension—as indicated by the use of antihypertensive medication—is positively...

  3. Recursos Organizacionais em Frigoríficos e sua Relação com a Implantação de Estratégias Voltadas à Sustentabilidade Ambiental: o caso do Grupo Marfrig Alimentos S.A.Organization Resources in Cold Storage Facilities and their Relations with the Implementation of Environmental Sustainability Strategies: the Marfrig Alimentos S.A. Group caseRecursos Organizativos en Frigoríficos y su Relación con la Implantación de Estrategias Dirigidas a la Sostenibilidad Medioambiental: el caso del Grupo Marfrig Alimentos S.A.

    Directory of Open Access Journals (Sweden)

    SEHNEM, Simone

    2012-06-01

    includes the poultry and pork division of the Marfrig Alimentos S.A. Group and is responsible for managing brands Seara, Mabella, DaGranja, Pena Branca, and has 30 plants located in various states of Brazil. As to the approach, this research work is focused on the qualitative aspect and uses the technique of semi-structured interviews and secondary collection of data from the company website. As for the procedures, it is classified as a case study. It was found that there is a predominance of intangible resources that are mobilized to enable the environmental strategy. Other features considered essential in this context of analysis and which were mentioned by respondents consist of culture, reputation, intellectual capital, knowledge, innovation, quality, reputation, brand, and finances. We conclude that the resources with value and rarity are capable of replication, but throughout a longer period of time and are linked to the culture and organizational routines specific to the company. Therefore, the contribution of this research is – from a monitoring exercise in an organization of the cold storage industry – a better understanding of the relations between the use of its resources and the implementation of environmental strategies in companies.RESUMENEl objetivo de este trabajo es especificar, de acuerdo con la clasificación utilizada por Barney (1991 y Hall (1992, los recursos tangibles e intangibles utilizados por una organización para establecer su estrategia ambiental. El estudio se llevó a cabo en la empresa Seara Marfrig, que incluye la división de las aves de corral y carne de cerdo de Marfrig Alimentos SA y que se encarga de gestionar las marcas Seara Mabella, DaGranja, Pena Branca, que posee 30 plantas ubicadas en varios estados de Brasil. En cuanto a la forma de abordar el problema, este trabajo de investigación se centra en la calidad y utiliza la técnica de entrevistas semiestructuradas y recolección de datos secundarios en la página web de la

  4. Composição química de nozes e sementes comestíveis e sua relação com a nutrição e saúde Chemical composition of nuts and edible seeds and their relation to nutrition and health

    Directory of Open Access Journals (Sweden)

    Jullyana Borges Freitas

    2010-04-01

    Full Text Available Esta revisão sistemática compara a composição química em nutrientes e outros compostos bioativos entre diferentes nozes e sementes comestíveis, relacionando-a com a nutrição e saúde. Foi realizada pesquisa bibliográfica nas bases Biological Abstracts, CAB Abstracts, Food Science and Technology Abstracts, Medline e Lilacs segundo os critérios de seleção: artigos de pesquisa original publicados nos últimos cinco anos em periódicos nacionais ou internacionais das áreas de Ciência de Alimentos, Medicina I e Medicina II, indexados no Institute for Scientific Information. Os artigos foram analisados conforme critérios de qualidade pré-estabelecidos. Nozes verdadeiras (amêndoas, avelãs, castanhas, castanhas-de-caju, castanhas-do-pará, macadâmias, nozes e pistaches e sementes comestíveis (amendoim e amêndoa de baru são boas fontes de lipídeos e proteínas. As frações lipídicas são compostas especialmente pelos ácidos graxos oléico (C18:1 e linoléico (C18:2, com destaque para a relação ω-6:ω-3 da macadâmia, noz, castanha e amêndoa de baru, perfil favorável à redução do risco de doenças cardiovasculares. As proteínas apresentam perfil de aminoácidos que atende grande parte das necessidades de escolares, contendo teores mais elevados de sulfurados que as leguminosas como feijões. Essas nozes e sementes comestíveis também são boas fontes de fitoesteróis, especialmente de β-sitoesterol; de minerais, sobretudo cálcio, ferro, zinco, selênio e potássio; de tocoferóis, com ênfase para o α-tocoferol, e de fibras alimentares insolúveis. Esses alimentos contêm alta densidade de nutrientes e de substâncias bioativas que potencializam seus efeitos benéficos à saúde e, portanto, o estudo e o consumo deles devem ser estimulados.This systematic review compares the chemical composition among different types of nuts and edible seeds with regard to nutrients and other bioactive compounds and relates this

  5. Desafios para a ação interdisciplinar na atenção básica: implicações relativas à composição das equipes de saúde da família Challenges to an interdisciplinary action in basic care: implications related to composition of family health teams

    Directory of Open Access Journals (Sweden)

    Gecioni Loch-Neckel

    2009-10-01

    Full Text Available O Programa Saúde da Família (PSF surge como uma nova estratégia de atenção à saúde e de reorientação do modelo de assistência. Partindo desses pressupostos, o presente artigo tem como objetivo refletir sobre a relação entre integralidade na atenção básica e a composição das equipes de saúde da família, na perspectiva dos integrantes da equipe mínima do PSF, caracterizando as possibilidades de atuação e contribuições de outros profissionais de saúde no PSF. Participaram da pesquisa profissionais com curso superior, membros de equipes de PSF de um município no sul do Brasil. A qualidade da experiência profissional ou pessoal acerca da atuação desses profissionais contribuiu para o conhecimento sobre suas possibilidades de intervenção. A investigação permitiu também analisar como a estratégia de saúde da família tem atingido os integrantes que constituem as equipes mínimas no contexto local. Além disso, evidenciou de que maneira a integralidade e a interdisciplinaridade têm sido entendidas pelos que compõem tais equipes, e as relações entre a composição das equipes e as (impossibilidades de concretizá-la.The Family Health Program emerges as a new strategy of health care as well as a reorientation of the assistance model. Based on these presuppositions, this article reflects on the relationship between integrality in basic care and the composition of family health teams, in the view of the Family Health Program minimum team members, characterizing the possible fields of action and the contributions of other health professionals in the Family Health Program. Undergraduates and members of a Family Health Program team from a certain city in the south of Brazil participated in this research. The quality of personal or professional expertise of these professionals contributed to a better understanding of their intervention possibilities. The investigation also allowed the analysis of how the family health

  6. A saúde mental em cuidados de saúde primários

    OpenAIRE

    Santos, Ana Isabel Monteiro dos

    2009-01-01

    As perturbações psiquiátricas no contexto da Clínica Geral / Medicina Geral e Familiar constituem um tema que tem vindo a ser estudado desde a década de 1960, sendo uma matéria complexa e com múltiplas implicações. Os estudos epidemiológicos mais recentes demonstram que as perturbações psiquiátricas e os problemas de saúde mental se tornaram a principal causa de incapacidade e uma das principais causas de morbilidade nas sociedades modernas. E, para além dos indivíduos que apresentam uma ...

  7. Educação em saúde como principal alternativa para promover a saúde do idoso

    Directory of Open Access Journals (Sweden)

    Danielli Gavião Mallmann

    2015-06-01

    Full Text Available Trata-se de uma revisão integrativa que objetivou identificar as evidências científicas sobre as ações educativas em saúde voltadas à promoção da saúde do idoso. A busca dos artigos foi realizada nas bases de dados Medline, Lilacs, BDENF, CINAHL e biblioteca virtual SciELO, por meio do cruzamento dos descritores Educação em Saúde, Idoso, Envelhecimento, Saúde do Idoso, Promoção da Saúde e Qualidade de vida, incluindo-se artigos publicados no período de 2003 a 2013, nos idiomas inglês, espanhol e português, realizados com idosos. Foram selecionados oito artigos, dos quais percebeu-se a qualidade de vida e a promoção do envelhecimento saudável como fatores resultantes das estratégias de educação em saúde. As ações de educação em saúde para idosos necessitam de metodologias que atentem para a complexidade do processo de envelhecimento e relacionem os fatores que cercam o indivíduo, como as crenças, os valores, as normas e os modos de vida.

  8. Timing attention : Cuing target onset interval attenuates the attentional blink

    NARCIS (Netherlands)

    Martens, S; Johnson, A

    2005-01-01

    Three experiments tested whether the attentional blink (AB; a deficit in reporting the second of two targets when it occurs 200-500 msec after the first) can be attenuated by providing information about the target onset asynchrony (TOA) of the second target relative to the first. Blocking the TOA di

  9. Effects of delayed-onset muscle soreness on masticatory function

    NARCIS (Netherlands)

    Yoshida, E.; Lobbezoo, F.; Fueki, K.; Naeije, M.

    2012-01-01

    The aim was to clarify the effects of experimentally provoked delayed-onset muscle soreness (DOMS) in the jaw-closing muscles on subjective and objective measures of masticatory function. Twenty-one dentate female subjects, without pain-related signs and symptoms of temporomandibular disorders, part

  10. An Odontoma Found in the Wake of Maxillary Sinusitis Onset

    OpenAIRE

    2013-01-01

    Sinusitis of dental origin is a relatively frequent entity, and odontomas are considered to be the most common odontogenic tumors of the oral cavity. Eruption and infection of odontomas are extremely rare. Here, we report an interesting case where odontoma was found in the wake of the maxillary sinusitis onset.

  11. The role of temperament in the relationship between early onset of tobacco and cannabis use: The TRAILS study

    NARCIS (Netherlands)

    Creemers, H.E.; Korhonen, T.; Kaprio, J; Vollebergh, W.A.M.; Ormel, J.; Verhulst, F.C.; Huizink, A.C.

    2009-01-01

    Background: While temperamental characteristics have been related to the onset of cannabis use, it is not clear at what point(s) along the trajectory from early onset of tobacco use (EOT) to early onset of cannabis use (EOC) these characteristics exert their impact. This study examined if (1) temper

  12. The role of temperament in the relationship between early onset of tobacco and cannabis use : The TRAILS study

    NARCIS (Netherlands)

    Creemers, Hanneke E.; Korhonen, Tellervo; Kaprio, Jaakko; Vollebergh, Wilma A. M.; Ormel, Johan; Verhulst, Frank C.; Huizink, Anja C.

    2009-01-01

    Background: While temperamental characteristics have been related to the onset of cannabis use, it is not clear at what point(s) along the trajectory from early onset of tobacco use (EOT) to early onset of cannabis use (EOC) these characteristics exert their impact. This study examined if (1) temper

  13. Evolução do financiamento da atenção à saúde bucal no SUS: uma análise do processo de reorganização assistencial frente aos incentivos federais Dental care financing evolution in the SUS: analysis of the process of health care reorganization in relation to federal incentives

    Directory of Open Access Journals (Sweden)

    George Edward Machado Kornis

    2011-01-01

    Full Text Available O trabalho descreve e analisa, na perspectiva do financiamento federal, o desenvolvimento da Política Nacional de Saúde Bucal (PNSB. O artigo considera o avanço no sentido da ampliação do acesso representado pela inserção das Equipes de Saúde Bucal (ESBs na Estratégia Saúde da Família (ESF e a criação dos Centros de Especialidades Odontológicas (CEOs e dos Laboratórios Regionais de Prótese Dentária (LRPDs. Não obstante a importância da ampliação desse acesso, o objetivo deste trabalho é refletir sobre a seguinte questão: de que forma e em que medida a Portaria nº 302/2009, que desvincula as EBSs da ESF, será capaz de garantir a manutenção do acesso já conquistado com continuidade do aporte de recursos financeiros? Para tal fim, foi realizada análise bibliográfica e documental abrangendo os períodos de vigência das Normas Operacionais do SUS até a edição do Pacto pela Saúde 2006. Nas considerações finais, os autores destacam que o maior aporte de recursos financeiros voltado para a atenção à saúde bucal está em sintonia com as políticas adotadas pelo Ministério da Saúde (MS na década de 1990: a reorganização da Atenção Básica através da ESF e a política de incentivos, como forma de repasse de recursos federais. Ainda é destacado o risco de retrocesso representado pela edição da referida Portaria, no sentido de comprometer tanto o processo de reorganização da atenção básica em SB quanto seu financiamento, uma vez que a política de incentivos do MS é voltada para esta Estratégia.This paper describes and analyzes, in the perspective of federal financing, the development of the so called Política Nacional de Saúde Bucal (PNSB [Dental Care National Politics]. It considers the progress of improvement of access provided by the inclusion of Dental Care Teams (DCT in the Family Health Strategy (FHS, and the creation of Odontological Specialties Centers (OEC and Regional Laboratories of

  14. Oral Anticoagulation: the impact of the therapy in health-related quality of life at six-month follow-up Anticoagulación oral: impacto de la terapia en la calidad de vida relacionada a la salud a lo largo de seis meses Anticoagulação oral: impacto da terapia na qualidade de vida relacionada à saúde ao longo de seis meses

    Directory of Open Access Journals (Sweden)

    Ariana Rodrigues da Silva Carvalho

    2013-02-01

    Full Text Available OBJECTIVE: to study the changes in health-related quality of life from beginning of anticoagulation therapy to six-month follow-up, and to study associations of sociodemographic and clinical characteristics with measures of quality of life and general health status at six-month follow-up, in individuals using oral anticoagulation due to various medical indications for the therapy. METHOD: prospective study performed at a city in the state of Paraná, Brazil, composed of 78 patients. Measures included the Duke Anticoagulation Satisfaction Scale and the Medical Outcomes Survey Short Form SF-36. RESULTS: mean age was 57 years (S.D.= 16 and 54% were women. Compared to the beginning of therapy, there was a statistically significant improvement in health-related quality of life at six-month follow-up. Linear regression analyses explained 32% and 30%, respectively, of the variance of the Duke Anticoagulation Satisfaction Scale and of the general health status. There was improvement in all components of the SF-36, except Mental Health. CONCLUSION: The use of oral anticoagulation therapy was associated with improvement in health-related quality of life in the first six months of therapy. This study is longitudinal and therefore, has fewer limitations than cross-sectional studies published to date in the Nursing literature in Brazil.OBJETIVO: Estudiar los cambios en la calidad de vida relacionada con la salud desde el inicio de la anticoagulación oral y al final de seis meses de tratamiento, y estudiar las asociaciones de las características sociodemográficas y clínicas con las medidas de calidad de vida y salud general seis meses después de iniciar la terapia, en pacientes con diversas indicaciones clínicas de anticoagulación oral. MÉTODO: Se realizó un estudio prospectivo en una ciudad de Paraná, Brasil, evaluando 78 pacientes. Las herramientas aplicadas fueron la Duke Anticoagulation Satisfaction Scale y el Medical Outcomes Survey Short Form

  15. Psychosocial influences in onset and progression of late life disability.

    Science.gov (United States)

    Mendes de Leon, Carlos F; Rajan, Kumar B

    2014-03-01

    Disability in older age has been related to several psychosocial characteristics, including social networks, social engagement, and depression. However, the exact role of these characteristics in the disablement process remains uncertain. Data come from a population-based study of black and white adults aged ≥65 years (N = 5,306), with up to 9 yearly data on the primary outcome measure, activities of daily living (ADL) disability. We use a two-part regression model to simultaneously test the association between each psychosocial characteristic and both onset and progression of ADL disability, while controlling for demographic variables, education, and mode of interview in the first model and health status variables in the second model. Social networks were negatively associated with onset of ADL disability but not associated with progression. The association became non-significant after adjustment for health status. Social engagement was negatively associated with both onset and progression of disability, even after adjustment for health status. Depression was significantly associated with onset of disability after adjustment for health status but not with progression of disability. The results suggest a differential role for psychosocial characteristics in the disablement process, with generally stronger associations for transitions to onset of ADL disability than progression of ADL disability.

  16. Premature birth and age at onset of puberty.

    Science.gov (United States)

    Hui, Lai Ling; Leung, Gabriel M; Lam, Tai Hing; Schooling, C Mary

    2012-05-01

    Premature birth is associated with poor metabolic health in both sexes, potentially via earlier pubertal timing. We examined the associations of gestational age and premature birth (Premature girls reached puberty about 4 months later than girls with ≥ 41 weeks' gestation (time ratio = 1.04 [95% confidence interval = 1.01-1.06]), adjusted for mother' age of menarche, mother's place of birth, and smoking during pregnancy. Gestational age was not associated with onset of puberty in boys (test for interaction by sex, P Premature birth was not related to earlier onset of puberty; instead, premature girls had later onset of puberty. Thus, the association between premature birth and subsequent cardiovascular risk is probably not mediated through the timing of pubertal onset. It is unclear whether onset, duration, or tempo of puberty is more relevant to the detrimental consequences of early puberty. Further studies investigating intrauterine, infant, and childhood influences on the duration and tempo of puberty may help unravel the early origins of cardiovascular diseases.

  17. Registry of Youth Onset Diabetes in India (YDR)

    Science.gov (United States)

    Praveen, Pradeep A.; Madhu, Sri Venkata; Mohan, Viswanathan; Das, Siddhartha; Kakati, Sanjeeb; Shah, Nalini; Chaddha, Manoj; Bhadada, Sanjay Kumar; Das, Ashok Kumar; Shukla, Deepak Kumar; Kaur, Tanvir; Tandon, Nikhil

    2016-01-01

    Background: With the aim of addressing the relative scarcity of information on youth-onset diabetes in India, the Indian Council of Medical Research (ICMR) decided to establish the Registry of People with Diabetes with Young Age at Onset (YDR) in 2006. The major objectives of YDR are to generate information on disease pattern or types of youth-onset diabetes including their geographical variations within India and to estimate the burden of diabetes complications. Methods: YDR is an observational multicenter clinic based registry enlisting physician diagnosed diabetes in individuals below 25 years of age. Diabetes was classified using symptom based clinical criteria. YDR data collection is coordinated through regional collaborating centers and their interacting reporting centers across India. A baseline and an annual follow-up proformas are used to obtain information on sociodemographic details, clinical profile, and anthropometric and laboratory measurements of the patients. Results: In phase 1, the registry has enrolled 5546 patients, in which type 1 diabetes mellitus (T1DM) was the most prevalent (63.9%), followed by youth-onset type 2 diabetes mellitus (T2DM) (25.3%). Conclusion: This registry provides a unique opportunity to study the natural history of youth-onset diabetes in India. PMID:27179010

  18. A interdisciplinaridade vivenciada no PET-Saúde = The interdisciplinarity experienced in the PET- Saúde program

    Directory of Open Access Journals (Sweden)

    Assega, Mariana Lieka

    2010-01-01

    Full Text Available Introdução: A incorporação da equipe de saúde bucal na Estratégia de Saúde da Família (ESF, em 2000, possibilitou a adoção de uma postura mais ativa de atenção primária nesta área, visto que a saúde bucal consiste em parte integrante e inseparável da saúde do indivíduo. A interação dos profissionais da saúde torna-se possível por meio de iniciativas como o PET-Saúde, o qual fomenta a formação profissional articulada com os profissionais da ESF, bem como, o processo de integração ensino-serviço-comunidade na perspectiva da interdisciplinaridade. Objetivo: Relatar a vivência de estudantes ao realizar uma pesquisa interdisciplinar. Descrição da experiência: Esse relato foi vivenciado no projeto PET-Saúde da Faculdade de Medicina de Marília, no sub projeto Saúde do Homem, visando construir e validar um instrumento de coleta de dados por meio da Técnica Delphi, para auxiliar a equipe de saúde detectar precocemente agravos odontológicos, visto que no Brasil, o perfil de saúde bucal, na faixa etária de 35 a 44 anos, está comprometido. Os participantes, deste estudo, são discentes de enfermagem e medicina, preceptora cirurgiã-dentista e tutora docente enfermeira. Para as atividades educacionais utilizou-se a metodologia ativa de ensino-aprendizagem. Conclusão: Os movimentos reflexivos, os espaços de diálogos propiciaram o desenvolvimento da investigação científica. Além disso, a aproximação do processo de validação pela Técnica Delphi, também permitiu ampliação do conhecimento multidisciplinar sobre saúde bucal. Esta vivência possibilitou qualificar a formação acadêmico-profissional na linha da interdisciplinaridade, sendo importante sua multiplicação para o fortalecimento da interação entre os profissionais e a articulação das ações de saúde

  19. Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia.

    Science.gov (United States)

    van der Heijden, Kristiaan B; Smits, Marcel G; van Someren, Eus J W; Boudewijn Gunning, W

    2005-06-01

    Research has shown efficacy of melatonin treatment to advance sleep-wake rhythms in insomnia. In healthy adults, direction and magnitude of the phase shift depends on the timing of administration relative to the phase position of the circadian system. Therefore, in the present study we investigated whether in children with chronic sleep onset insomnia (SOI) efficacy of melatonin treatment in the early evening could be predicted from dim light melatonin onset (DLMO), a phase marker of the circadian system. We combined data of two previously published double blind, randomized, placebo-controlled trials in 110 participants, aged 6-12 years. Sleep was actigraphically estimated, and saliva collected, at baseline and in the third week of a 4-week treatment period with 5 mg melatonin or placebo at 18:00 or 19:00 hours. Primary outcome measures were pre- to post-treatment changes in dim light melatonin onset (DeltaDLMO), sleep onset (DeltaSO), sleep latency (DeltaSL), and total sleep duration (DeltaTSD). Melatonin advanced DLMO with +1:12 h (P melatonin-treated group, but not in the placebo-treated group, pretreatment DLMO was significantly related to DeltaDLMO [F(1, 29) = 7.28, P = 0.012] and DeltaSO [F(1, 25) = 7.72, P = 0.010]. The time interval between treatment administration and pretreatment DLMO (INT) was only significantly related to DeltaSO [F(1,26) = 5.40, P = 0.028]. The results suggest that in children with SOI, the efficacy of early evening melatonin to advance sleep onset and endogenous melatonin onset increases the later the pretreatment DLMO is.

  20. Cumulative Production Per Township - SaMiRa

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset contains a selected township grid within the Sagebrush Mineral Resource Assessment project (SaMiRa) study area attributed with cumulative oil and gas...

  1. Desenvolvimento econômico, desigualdade e saúde

    Directory of Open Access Journals (Sweden)

    Pedro Reginaldo Prata

    1994-09-01

    Full Text Available O autor se refere a dimensão socioeconômica, individual e coletiva do fenômeno saúde-doença. Refere-se também ao fato das populações estarem sobre a influência desigual de fatores de risco e de proteção à saúde. Discute as desigualdades no desenvolvimento e a relação entre desenvolvimento, riqueza, saúde e justiça social. Questiona as teorias de desenvolvimento econômico, diferenciando desenvolvimento de crescimento. Cunha os conceitos de armadilha do desenvolvimento e refugiados sociais. Define uma comunidade saudável. Propõe a necessidade de mudança no modelo de desenvolvimento. Baliza o papel e as limitações do setor saúde no que diz respeito a iniqüidade social.

  2. O tempo no processo de trabalho em saúde: uma abordagem sociológica El tiempo en el proceso de trabajo en salud: un abordaje sociológico Time in the health-related work process: a sociological approach

    Directory of Open Access Journals (Sweden)

    Maria Cristina de Mello

    2007-03-01

    Full Text Available O conceito de tempo, do qual fazemos uso, situa-se em um alto nível de generalização e de síntese, sendo um dos mais ricos patrimônios sociais do saber. Percebe-se, ao longo da evolução humana, que a concepção do tempo passa por vários estágios, iniciando como uma forma cíclica, descontínua e qualitativa, até assumir o sentido linear, progressivo e quantitativo, quando surge o sentimento de irreversibilidade. O tempo tem merecido destaque especial, principalmente no campo das ciências humanas e sociais, pois descobriu-se o seu valor nas organizações, isto é, no trabalho e também fora dele. A descoberta desse valor tornou-o um elemento chave na gestão de recursos das organizações, contribuindo tanto para o desempenho individual, quanto coletivo. Portanto, este artigo propõe uma reflexão sobre o tempo no trabalho, dentro de uma perspectiva sociológica, correlacionando-o com o desenvolvimento e evolução da sociedade, bem como com o processo de trabalho em saúde.El concepto de tiempo, del cual hacemos uso, se sitúa en un alto nivel de generalización y de síntesis, siendo uno de los más ricos patrimonios sociales del saber. Se percibe, a lo largo de la evolución humana, que la concepción del tiempo pasa por varias fases, iniciándose de una forma cíclica, discontinua y cualitativa, hasta asumir el sentido lineal, progresivo y cuantitativo, cuando surge el sentimiento de irreversibilidad. El tiempo ha merecido destaque especial, principalmente en el campo de las ciencias humanas y sociales, pues se descubrió su valor en las organizaciones, es decir, en el trabajo y también fuera de él. El descubrimiento de ese valor lo convirtió en un elemento clave en la gestión de recursos de las organizaciones, contribuyendo tanto para el desempeño individual, cuanto para el colectivo. Por tanto, este artículo propone una reflexión sobre el tiempo en el trabajo, dentro de una perspectiva sociológica, correlacion

  3. A relação trabalho-saúde de enfermeiros do PSF no município de São Paulo La relacion trabajo/salud de las enfermeras del programa salud de la familia en lo municipio de São Paulo Nurses'job and its relations to health in the family health program

    Directory of Open Access Journals (Sweden)

    Viviane Camargo Santos

    2007-12-01

    Full Text Available Este estudo tomou como objeto a relação trabalho/saúde dos enfermeiros do PSF e como objetivo compreender as características do trabalho desses enfermeiros e a relação entre os processos de fortalecimento e de desgaste que neles se expressam. Foram entrevistadas 16 enfermeiras de UBS de São Paulo. As formas de trabalhar das entrevistadas foram analisadas conforme as categorias: processo de trabalho, exploração da subjetividade, polivalência, desgaste e fortalecimento, verificando-se, em cada uma delas, os potenciais de fortalecimento e de desgaste gerados. O fortalecimento advém principalmente da relação prazerosa com o objeto/finalidade do trabalho e com o trabalho em si. As enfermeiras convivem com a expectativa das suas potencialidades para solucionar problemas e ao mesmo tempo com a impossibilidade de oferecer respostas à população. O desgaste se concretiza em cansaço físico e mental, levando à hipertensão, alergias, dores de estômago e outros.El objeto de este estudio fue la relación trabajo/salud de las enfermeras del Programa Salud de la Familia. El objetivo fue comprender las características del trabajo de esas enfermeras y la relación entre los procesos de fortalecimiento y de desgaste que manifestaron. Fueron entrevistadas 16 enfermeras que trabajan en unidades básicas de salud de São Paulo. Se analizaron las formas de trabajar según: proceso de trabajo, exploración de la subjetividad, polivalencia, desgaste y fortalecimiento. El potencial de fortalecimiento provino principalmente de la relación agradable con el objeto/finalidad del trabajo y con el trabajo en sí. Las enfermeras conviven con la expectativa de sus potencialidades para solucionar problemas y al mismo tiempo con la imposibilidad de encontrar respuestas para los problemas de la población. El desgaste se manifestó en la debilidad física y mental, que originó hipertensión, alergias, dolor de estómago, entre otras.The object of this study

  4. Discussion of CoSA: Clustering of Sparse Approximations

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, Derek Elswick [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-03-07

    The purpose of this talk is to discuss the possible applications of CoSA (Clustering of Sparse Approximations) to the exploitation of HSI (HyperSpectral Imagery) data. CoSA is presented by Moody et al. in the Journal of Applied Remote Sensing (“Land cover classification in multispectral imagery using clustering of sparse approximations over learned feature dictionaries”, Vol. 8, 2014) and is based on machine learning techniques.

  5. Desigualdade social e saúde no Brasil

    Directory of Open Access Journals (Sweden)

    Neri Marcelo

    2002-01-01

    Full Text Available Esse artigo estuda a relação entre desigualdade social e saúde no Brasil. A estratégia usada foi avaliar as necessidades e o consumo dos serviços de saúde, bem como o acesso a seguro saúde ao longo da distribuição de renda. Adicionalmente, por meio da estimação de uma regressão logística, foram avaliados outros determinantes do consumo dos serviços de saúde, com o intuito de se conhecer aonde e quem utiliza esses serviços no país. Os dados foram extraídos da Pesquisas Nacional de Amostra por Domicilio da Fundação Instituto Brasileiro de Geografia e Estatística levada a campo em 1998. Em geral, observou-se que os indivíduos nos primeiros décimos da distribuição de renda têm pior acesso a seguro saúde, necessitam de maiores cuidados médicos, mas consomem menos os serviços de saúde. As outras características extra rendimento indicam que os principais determinantes para o consumo dos serviços de saúde estariam fortemente associados aos grupos sociais mais privilegiados (de maior escolaridade, acesso a seguro saúde, água, esgoto, luz, coleta de lixo e a fatores que apontam para capacidade de geração de oferta desses serviços no país.

  6. Review of underground salt attenuation measurements for SalSA

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Amy, E-mail: connolly@mps.ohio-state.edu [1040 Physics Research Building, 191 West Woodruff Avenue, Columbus, OH 43210-1117 (United States)

    2012-01-11

    We report on the status of the Salt Sensor Array (SalSA), a proposed experiment for detecting ultra-high energy neutrinos through the radio Cherenkov technique with an array of radio-microwave antennas embedded in a large, naturally occurring salt formation. We review the measurements to date aimed at assessing SalSA's feasibility, including a return visit of the Hockley Salt Mine in Hockley, Texas, and discuss the current status of the project.

  7. Early-Onset Neonatal Sepsis

    Science.gov (United States)

    Simonsen, Kari A.; Anderson-Berry, Ann L.; Delair, Shirley F.

    2014-01-01

    SUMMARY Early-onset sepsis remains a common and serious problem for neonates, especially preterm infants. Group B streptococcus (GBS) is the most common etiologic agent, while Escherichia coli is the most common cause of mortality. Current efforts toward maternal intrapartum antimicrobial prophylaxis have significantly reduced the rates of GBS disease but have been associated with increased rates of Gram-negative infections, especially among very-low-birth-weight infants. The diagnosis of neonatal sepsis is based on a combination of clinical presentation; the use of nonspecific markers, including C-reactive protein and procalcitonin (where available); blood cultures; and the use of molecular methods, including PCR. Cytokines, including interleukin 6 (IL-6), interleukin 8 (IL-8), gamma interferon (IFN-γ), and tumor necrosis factor alpha (TNF-α), and cell surface antigens, including soluble intercellular adhesion molecule (sICAM) and CD64, are also being increasingly examined for use as nonspecific screening measures for neonatal sepsis. Viruses, in particular enteroviruses, parechoviruses, and herpes simplex virus (HSV), should be considered in the differential diagnosis. Empirical treatment should be based on local patterns of antimicrobial resistance but typically consists of the use of ampicillin and gentamicin, or ampicillin and cefotaxime if meningitis is suspected, until the etiologic agent has been identified. Current research is focused primarily on development of vaccines against GBS. PMID:24396135

  8. Early onset (childhood) monogenic neuropathies.

    Science.gov (United States)

    Landrieu, Pierre; Baets, Jonathan

    2013-01-01

    Hereditary neuropathies (HN) with onset in childhood are categorized according to clinical presentation, pathogenic mechanism based on electrophysiology, genetic transmission and, in selected cases, pathological findings. Especially relevant to pediatrics are the items "secondary" versus "primary" neuropathy, "syndromic versus nonsyndromic," and "period of life." Different combinations of these parameters frequently point toward specific monogenic disorders. Ruling out a neuropathy secondary to a generalized metabolic disorder remains the first concern in pediatrics. As a rule, metabolic diseases include additional, orienting symptoms or signs, and their biochemical diagnosis is based on logical algorithms. Primary, motor sensory are the most frequent HN and are dominated by demyelinating autosomal dominant (AD) forms (CMT1). Other forms include demyelinating autosomal recessive (AR) forms, axonal AD/AR forms, and forms with "intermediate" electrophysiological phenotype. Peripheral motor neuron disorders are dominated by AR SMN-linked spinal muscular atrophies. (Distal) hereditary motor neuropathies represent 40 genes with various biological functions have been found to be responsible for primary HN. Many are responsible for various phenotypes, including some without the polyneuropathic trait, and some for various types of transmission.

  9. Apoio social e saúde entre idosos

    Directory of Open Access Journals (Sweden)

    Ramos Marília P.

    2002-01-01

    Full Text Available O presente artigo trata da relação entre a saúde dos idosos e relacionamentos sociais, bem como na interpretação e entendimento desta problemática sob a luz de dois enfoques teóricos: um macro, centrado na Teoria da Integração Social de Emile Durkheim e outro micro, centrado na Teoria das Trocas, de Peter Blau, com ênfase na Teoria da Eqüidade. A integração social (freqüência de contatos pode ter efeitos negativos na saúde, mas isto tem de ser medido pela qualidade dos contatos. Algumas conclusões apresentadas indicam que as relações sociais têm um efeito na saúde, no sentido de que as pessoas, nas sociedades modernas, esperam a reciprocidade, e, quando isto não é possível, principalmente na fase do envelhecimento, as pessoas sentem-se dependentes, e isso pode afetar a saúde de diferentes maneiras. Por outro lado, quando as pessoas têm problemas de saúde, elas experienciam uma falta de relações sociais balanceadas devido à incapacidade para trocar em bases iguais. Sendo assim, conclui-se que a relação entre relações sociais e saúde na população idosa pode ser uma relação recíproca.

  10. Pressure Gradient Evolution and Substorm Onset

    Science.gov (United States)

    Zhonghua, Y.; Pu, Z.; Cao, X.; Nishimura, T.; Zhang, H.; Fu, S.; Xie, L.; Guo, R.

    2011-12-01

    Near-Earth current disruption (NECD) and substorm current wedge (SCW) formation are two related key phenomena for substorm onset. They are believed to be in close association with evolution of pressure gradient near the inner edge of plasma sheet. In the past, a few attempts have been made to investigate the pressure gradient in the late growth phase based on one- or two-spacecraft observations (e.g. , Korth et al., 1991; Pu et al., 1992; Shiokawa et al., 1998; Xing et al., 2010, 2011,etc). In this paper, with linearization assumption in the inner-probe region, we use THEMIS three-probe measurements to estimate the pressure gradient near the inner edge of the equatorward and duskward (dawnward) plasma sheet where pressure gradient in the Z-direction is almost vanished. We therefore can roughly get the two-dimensional pressure gradient in the X- and Y-direction simultaneously. Our observations indicate that the pressure gradients in both the X- and Y-direction enhance right after (within one minute) substorm onset. The enhanced pressure gradient in the Y-direction is duskward (dawnward) when the probes are in the duskside (dawnside) of the enhanced earthward flow in the growth phase. The enhanced dawn-dusk pressure gradients can drive downward field-aligned current (FAC) on the dawnside and upward FAC on the duskside, thus make contributions to the NECD and formation of SCW. THEMIS in situ data and all-sky auroral images for two events are presented, followed by a brief discussion.

  11. Organizações sociais de saúde: o modelo do Estado de São Paulo

    Directory of Open Access Journals (Sweden)

    Ibañez Nelson

    2001-01-01

    Full Text Available A experiência de um novo modelo de gestão dos serviços públicos de saúde implantada no Estado de São Paulo é analisada neste artigo, a partir da caracterização da especificidade da lei que regulamenta a criação das Organizações Sociais de Saúde, tendo como referencial a gestão estadual do Sistema Único de Saúde, seus antecedentes e a situação atual. Os dados apresentados foram coletados a partir de relatórios produzidos pela equipe técnica responsável pelo convênio entre a Secretaria e a Faculdade de Saúde Pública -- USP, para acompanhamento do projeto. Os resultados encontrados demonstraram o cumprimento satisfatório por parte das OSS/SUS, a partir das metas estabelecidas no contrato de gestão pela Secretaria, para o primeiro ano de atividade. O trabalho aborda, ainda, as perspectivas do novo modelo e da atual política. Os autores alertam para o fato de que a regulação, através de um novo contrato de gestão, deve considerar o desempenho das OSS, enfatizando processos, resultados e inserção sistêmica, referenciada pela demanda de saúde regional.

  12. Ações de cuidados relacionados ao abuso e dependências de drogas: desafio da prática do Programa Saúde da Família. Actions and care related to drug abuse and addiction; the challenge in the practice of the Family Health program

    Directory of Open Access Journals (Sweden)

    Alda Martins Gonçalves

    2010-11-01

    Full Text Available Este estudo tem como objeto a prática de cuidados relacionados ao abuso e à dependência de drogas no cotidiano de uma equipe do Programa Saúde da Família (PSF. Reconhecendo a gravidade dos problemas relacionados ao abuso e à dependência de drogas e suas implicações para o indivíduo, a família e a comunidade, que refletem no processo de formação e na prática dos profissionais, tivemos como objetivos desenvolver com os membros de uma equipe do PSF uma ação-reflexão sobre essa prática,visando contribuir para a superação de problemas e contradições enfrentados pela equipe no cotidiano de trabalho. Realizamos uma investigação com abordagemqualitativa, na modalidade de pesquisa-ação, fundamentada pelo materialismo histórico-dialético como parte intrínsica da visão de mundo vinculada à práxis. O cenário da pesquisa foi a área geopolítica de atuação de uma equipe do Programa no município de Contagem, Estado de Minas Gerais, Brasil. A pesquisa de campo foi realizada no período de setembro de 2000 a julho de 2001 e teve como sujeitos os integrantes da equipe (um médico, uma enfermeira, uma auxiliar de enfermagem e quatro agentes comunitários de saúde. Os resultados da pesquisa confirmaram a tese inicial sobre a importância do PSF para a prática de cuidados relacionados ao abuso e à dependência de drogas. Os resultados evidenciaram fragilidades e potencialidades técnicas (práticas e políticas do Programa para enfrentar esse desafio, além de apontar possibilidades de superação mediante investimento na capacitação da equipe e na criação de um projeto de ação comunitária. A pesquisa contribuiu com subsídio para formulação de políticas de saúde, voltadas para o desafio de desenvolver cuidados relacionados ao abuso e à dependência de drogas do PSF, bem como de outros serviços de saúde que venham valer-se dessa experiência para aplicá-la em condições semelhantes.

  13. Identifying Risk Factors for Late-Onset (50+) Alcohol Use Disorder and Heavy Drinking

    DEFF Research Database (Denmark)

    Emiliussen, Jakob; Nielsen, Anette Søgaard; Andersen, Kjeld

    2017-01-01

    This systematic review seeks to expand the description and understanding of late-onset AUD and asks “Which risk factors have been reported for late-onset heavy drinking and AUD?” Method: Using PRISMA guidelines, a literature review and search was performed on May 19, 2015 using the following...... with an increased risk for late-onsetAUDor heavy drinking,whereas retirement, death of a spouse or a close relative does not increase the risk. Discussion: Inherent differences in measurements and methodologies precluded a meta-analysis. Therefore, the results presented here are descriptive in nature. Most studies...... possibly has led to misrepresentations and preconceptions on the complex nature of late-onset AUD. There is limited evidence for any specific risk factor for late-onset AUD or heavy drinking. We suggest the adoption of a qualitative approach to uncover what is intrinsic to late-onset AUD followed...

  14. Development and validation of a health related quality of life questionnaire for Brazilian children with epilepsy: preliminary findings Construção e validação de um questionário de qualidade de vida relacionada à saúde para crianças brasileiras com epilepsia: resultados preliminares

    Directory of Open Access Journals (Sweden)

    Heber de Souza Maia Filho

    2005-06-01

    Full Text Available PURPOSE: To construct a multidimensional questionnaire that analyses the epileptic child quality of life from the parental point of view. METHOD: The pilot questionnaire was composed of 157 questions distributed in several dimensions. Fifty-one epileptic children's parents answered the questionnaire. The instrument was tested in its diverse properties: frequency of endorsement, homogeneity (Cronbach alpha, criterion and face validity, and later it was reduced. RESULTS: Endorsement frequency excluded 65 questions that did not attain a minimum of 5% response per item. Cronbach alpha was as follows: physical (0.93, psychological (0.91, social (0.91, familiar (0.70, cognitive (0.92, medical (0.30 and economical (0.37. Patient groups, in relation to seizure control, significantly differed only in physical domain and total score, although there was a trend to differences in other domains. The final questionnaire (QVCE50 has 50 items, with good homogeneity in the physical, psychological and cognitive domains. CONCLUSION: QVCE-50 is a promissing Brazilian HRQL questionnaire for children with epilepsy.It needs to be applied in a larger population to confirm its psychometric properties.OBJETIVO: Construir um questionário multidimensional analisando a qualidade de vida da criança com epilepsia do ponto de vista dos responsáveis. MÉTODO: O questionário piloto foi composto de 157 itens distribuídos em várias dimensões. Cinqüenta e um responsáveis de crianças com epilepsia responderam ao questionário. O instrumento foi testado em suas diversas propriedades freqüência de endosso, homogeneidade (alfa de Cronbach, validade de critério e aparência, sendo posteriormente reduzido. RESULTADOS: A freqüência de endosso excluiu 65 questões que não atingiram um mínimo de 5% de respostas por item. O alfa de Cronbach foi: domínio físico (0,93, psicológico (0,91, social (0,91, familiar (0,70, cognitivo (0,92, médico (0,30 e econômico (0,37. Os

  15. Health related quality of life of patients undergoing oral anticoagulation therapy Calidad de vida relacionada a la salud de pacientes que usan anticoagulación oral Qualidade de vida relacionada à saúde de pacientes em uso de anticoagulação oral

    Directory of Open Access Journals (Sweden)

    Inaiara Scalçone Almeida Corbi

    2011-08-01

    Full Text Available This is a descriptive cross-sectional study, which aimed to analyze the health related quality of life (HRQoL and its relationship with gender, age, duration and indication for the use of oral anticoagulants. A total of 178 patients were interviewed and the HRQoL was assessed through eight domains of the SF-36. The descriptive statistics used were, the Student's t, ANOVA and Tukey's tests for the comparison of the means between the groups. The indication for use was predominantly the metallic prosthetic heart valve (50% with warfarin the most widely prescribed anticoagulant (83.3%. The means of the domains of the SF-36 ranged from 82 (Social aspects to 54.8 (Physical aspects. Women, elderly, patients diagnosed with atrial fibrillation and with less than one year of medication use, presented a worse HRQoL evaluation. The results obtained can guide nursing actions, in that they indicate possible associations between the HRQoL and the sociodemographic and clinical variables of the patients.Se trata de un estudio descriptivo, de tipo corte transversal, que tuvo como objetivo analizar la calidad de vida relacionada a la salud (CVRS y su relación con sexo, edad, tiempo e indicación de uso de anticoagulantes orales. Fueron entrevistados 178 pacientes y la CVRS fue evaluada por los ocho dominios del SF-36. Fue utilizada estadística descriptiva, las pruebas: t Student, ANOVA y Tukey, para comparación de los promedios entre los grupos. La indicación para el uso fue predominantemente la prótesis cardíaca metálica (50% y la warfarina el anticoagulante más prescrito (83,3%. Los promedios de los dominios del SF-36 variaron de 82 (Aspectos sociales a 54,8 (Aspectos físicos. Mujeres, ancianos, y pacientes con diagnóstico de fibrilación atrial y con menos de un año de uso del medicamento, presentaron peor evaluación de la CVRS. Los resultados obtenidos pueden orientar acciones de enfermería, en la medida en que indican posibles asociaciones entre

  16. Health-related quality of life and depressive symptoms in undergraduate nursing students Calidad de vida relacionada a la salud y síntomas depresivos de estudiantes del curso de graduación en enfermería Qualidade de vida relacionada à saúde e sintomas depressivos de estudantes do curso de graduação em Enfermagem

    Directory of Open Access Journals (Sweden)

    Ismelinda Maria Diniz Mendes Souza

    2012-08-01

    Full Text Available This is a descriptive, cross-sectional study aimed at investigating the health-related quality of life (HRQoL of nursing students and its relationship with year of training, sociodemographic variables and the intensity of depressive symptoms. A convenience sample of 256 students, out of 353 eligible (72%, responded to the Medical Outcomes Study - The 36 Item Short-Form Health Survey (SF-36 and the Beck Depression Inventory (BDI (self-administered. Final-year students, females and students with a higher intensity of depressive symptoms presented lower SF-36 scores in the physical functioning, vitality and social functioning domains. Institutional psychopedagogic support programs may minimize this negative impact on the HRQoL and encourage better professional performance of students in higher vulnerability situations.Se trata de un estudio descriptivo y transversal que investigó la calidad de vida relacionada a la salud (CVRS de los estudiantes de enfermería y la relación con años de estudio, las variables sociodemográficas y la intensidad de los síntomas depresivos. Una muestra accidental de 256 estudiantes de 353 elegibles (72% respondió el Medical Outcomes Study - The 36 Item Short-Form Health Survey (SF-36 y el Inventario de Depresión de Beck (IDB (auto-aplicación. Estudiantes del último año del curso, los del sexo femenino y con mayor intensidad de síntomas depresivos, presentaron menores puntuaciones del SF-36 en los dominios capacidad funcional, vitalidad y aspectos sociales. El impacto es mayor en el último año del curso, los estudiantes de sexo femenino o con síntomas depresivos. Programas de apoyo psicológico podrían minimizar este impacto y contribuir a una mejor formación y desempeño profesional de los estudiantes en situación de mayor vulnerabilidad.Trata-se de estudo descritivo e transversal, que investigou a qualidade de vida relacionada à saúde (QVRS de estudantes de Enfermagem e a relação da QVRS com o ano

  17. Correlação entre parâmetros clínicos e qualidade de vida relacionada à saúde em mulheres com DPOC Correlation between clinical parameters and health-related quality of life in women with COPD

    Directory of Open Access Journals (Sweden)

    Nilton Maciel Mangueira

    2009-03-01

    Full Text Available OBJETIVO: Correlacionar a qualidade de vida relacionada à saúde (QVRS de mulheres portadoras de DPOC com parâmetros clínicos e com a distância percorrida no teste de caminhada de seis minutos (TC6. MÉTODOS: Estudo transversal com 30 mulheres portadoras de DPOC leve ou moderada, atendidas no Ambulatório de Pneumologia do Hospital Universitário Presidente Dutra. Foi aplicado o Saint George's Respiratory Questionnaire (SGRQ, assim como foram realizadas as medidas das pressões respiratórias, da espirometria e dos resultados do TC6. Executou-se a análise estatística descritiva, assim como o teste t de Student para variáveis dependentes, o coeficiente linear de Pearson para correlações de variáveis numéricas e o de Spearman para variáveis ordinais. RESULTADOS: A QVRS esteve, na grande maioria das mulheres entrevistadas, comprometida, em graus variados, de acordo com o escore total do SGRQ. Os escores totais do SGRQ da maioria das participantes estavam entre o segundo e o terceiro quartil, o que reflete baixa QVRS. As participantes apresentaram ainda baixa capacidade funcional no TC6, com distância média percorrida (317,7 m e força muscular inspiratória (-53,48 cmH2O e expiratória (69,5 cmH2O abaixo dos valores de normalidade. Não houve correlação entre a QVRS e o índice de massa corpórea e a função pulmonar. No entanto, houve correlação linear negativa com a idade, a PImáx e o TC6 e correlação positiva com a sensação de dispneia e de fadiga. CONCLUSÕES: A QVRS medida pelo SGRQ das pacientes com DPOC desta pesquisa esteve muito comprometida, de modo a provocar limitações graves na funcionalidade, no controle da respiração e na vida pessoal.OBJECTIVE: To correlate health-related quality of life (HRQL of women with COPD with clinical parameters and with the six-minute walk distance (6MWD; six-minute walk test. METHODS: Cross-sectional study involving 30 female patients diagnosed with mild or moderate COPD treated

  18. Estado nutricional dos adolescentes e sua relação com variáveis sociodemográficas: Pesquisa Nacional de Saúde do Escolar (PeNSE, 2009 Nutritional status of adolescents and its relation with socio-demographics variables: National Adolescent School-based Health Survey (PeNSE, 2009

    Directory of Open Access Journals (Sweden)

    Cora Araújo

    2010-10-01

    Full Text Available Objetivou-se descrever o estado nutricional dos adolescentes da 9ª série de escolas públicas e privadas das capitais brasileiras e sua associação com variáveis sociodemográficas. Por meio de questionário autopreenchido, foram registradas informações sobre sexo, raça/cor, idade, escola pública/privada, macrorregião do país, escolaridade materna e posse de bens familiares. Peso e altura foram aferidos segundo procedimentos padronizados. A altura para idade e o Índice de Massa Corporal para idade foram avaliados segundo critérios da Organização Mundial da Saúde. Obtiveram-se medidas antropométricas de 58.971 adolescentes, sendo que 2,9% apresentaram déficit estatural e 2,9% magreza. O excesso de peso foi de 23,0% e a obesidade de 7,3%, sendo mais altos no Sul e no Sudeste do país. Déficits de altura e peso, excesso de peso e obesidade foram mais prevalentes nos meninos. Os déficits foram superiores nas escolas públicas, e o excesso de peso e a obesidade nas privadas. Adolescentes cujas mães eram de menor escolaridade ou de famílias mais pobres apresentaram maior déficit de altura; o inverso ocorreu com o excesso de peso e a obesidade. Prevalências de déficits, excesso de peso e obesidade ressaltam a necessidade de intervenções nutricionais direcionadas para esta fase da vida.The aim of this study was to describe the nutritional status of adolescents in the 9th year of public and private schools of the Brazilian capitals and its association with socio-demographic variables. By means of a self-completed questionnaire, information related to sex, race, age, public/private school, macro-region of the country, maternal education and family possessions were recorded. Measures of weight and height were measured according to standardized procedures. Height for age and body mass index for age was evaluated according to the World Health Organization reference. Anthropometric measurements of 58,971 adolescents were obtained, of

  19. Tecnologias leves em saúde e sua relação com o cuidado de enfermagem hospitalar Tecnologías leves en salud y su relación con el cuidado de enfermería hospitalaria Light technologies in health and its relation with the hospital nursing care

    Directory of Open Access Journals (Sweden)

    Denise Conceição da Silva

    2008-06-01

    Full Text Available O objeto da pesquisa foi a incorporação de tecnologias leves no contexto hospitalar, na ótica de enfermeiras, e sua relação com o cuidado de enfermagem. Objetivos: caracterizar as tecnologias consideradas leves no hospital, na ótica de enfermeiras, e analisar as concepções de enfermeiras sobre o uso dessas tecnologias no cuidado de enfermagem. Fundamentou-se na classificação dos diferentes tipos de tecnologias no trabalho em saúde e em pressupostos sobre o cuidado de enfermagem. Pesquisa exploratória, qualitativo-descritiva, desenvolvida em dois hospitais universitários na Cidade do Rio de Janeiro. Os dados foram coletados através da técnica de criatividade e sensibilidade "Almanaque", conjugada à entrevista semi-estruturada. Do discurso das enfermeiras emergiram tecnologias fundamentadas em suas experiências de cuidado. Suas concepções sobre tecnologias leves revelaram o que teoristas de enfermagem referem como atributos da relação humana no cuidado. Essas, quando discutidas no âmbito do cuidado de enfermagem, emergem como qualidades do cuidado em si.El objeto de la investigación fue la incorporación de tecnologías leves en hospitales, desde la perspectiva de las enfermeras y las relaciones establecidas con el cuidado de enfermería. Objetivos: caracterizar las tecnologías consideradas leves en el hospital, desde la perspectiva de las enfermeras; y analizar las concepciones de las enfermeras sobre el uso de estas tecnologías en el cuidado de enfermería. El estudio se fundamentó en la clasificación de diferentes tipos de tecnologías aplicadas en el área de la salud y en presuposiciones sobre el cuidado de enfermería. Investigación exploratoria, cualitativa y descriptiva, desarrollada en dos hospitales universitarios de la ciudad de Rio de Janeiro. Los datos fueron recolectados a través de dos técnicas: creatividad y sensibilidad, denominada "Almanaque," y entrevista semi-estructurada. De los discursos de las

  20. SA BASED SOFTWARE DEPLOYMENT RELIABILITY ESTIMATION CONSIDERING COMPONENT DEPENDENCE

    Institute of Scientific and Technical Information of China (English)

    Su Xihong; Liu Hongwei; Wu Zhibo; Yang Xiaozong; Zuo Decheng

    2011-01-01

    Reliability is one of the most critical properties of software system.System deployment architecture is the allocation of system software components on host nodes.Software Architecture (SA)based software deployment models help to analyze reliability of different deployments.Though many approaches for architecture-based reliability estimation exist,little work has incorporated the influence of system deployment and hardware resources into reliability estimation.There are many factors influencing system deployment.By translating the multi-dimension factors into degree matrix of component dependence,we provide the definition of component dependence and propose a method of calculating system reliability of deployments.Additionally,the parameters that influence the optimal deployment may change during system execution.The existing software deployment architecture may be ill-suited for the given environment,and the system needs to be redeployed to improve reliability.An approximate algorithm,A*_D,to increase system reliability is presented.When the number of components and host nodes is relative large,experimental results show that this algorithm can obtain better deployment than stochastic and greedy algorithms.

  1. Saúde bucal no Brasil Oral health in Brazil

    Directory of Open Access Journals (Sweden)

    Vitor Gomes Pinto

    1983-08-01

    Full Text Available Apresenta-se um retrato sobre a saúde bucal no Brasil, com ênfase em informações relativas à situação econômica e epidemiológica, prevenção da cárie dental, recursos humanos, montante de gastos financeiros e estrutura de prestação de serviços. O país mostra quadro típico de uma área em desenvolvimento, com elevada incidência de problemas, crescente oferta de cirurgiões-dentistas e difícil acesso aos serviços ofertados mormente face a barreiras de ordem econômica. Visando expandir cuidados odontológicos e reduzir a incidência dos principais problemas, propõe-se um programa de serviços básicos de âmbito nacional.The oral health situation in Brazil is described, with special emphasis on data relating to the economic and epidemiological situation, caries prevention, human resources, health expenditure and dental care structure. The country presents a picture typical of a developing area, with high disease rates, an increase in the offer of dentists and access to dental care hindered principally by economic barriers. A comprehensive program of basic services in odontology is proposed, with the objective of expanding dental care and reducing the incidence of more prevalent problems.

  2. Revista de Saúde Pública: 50 years disseminating the knowledge in nutrition

    Science.gov (United States)

    Sichieri, Rosely; Pereira, Rosangela A

    2016-01-01

    ABSTRACT This work describes and comments on articles in the area of Public Health Nutrition published in Revista de Saúde Pública (RSP – Public Health Journal) from 1967 to 2016. We searched in the PubMed database restricted to the periodical “Revista de Saúde Pública” and using terms related to key topics in the area of Public Health Nutrition. We retrieved 742 articles and, after exclusion of duplicates and articles unrelated to the subject, we analyzed 441 articles, grouped according to subject: dental caries, anemia, hypovitaminosis A, macro/micronutrients, malnutrition, nutritional assessment, overweight/obesity, food consumption, low birthweight, and breastfeeding. We observed significant increase in the number of articles published and diversification of subjects addressed over the 50 years, representing the consistent development of the scientific field of Nutrition in Brazil. Since its inception, RSP has played an important role in the dissemination of knowledge about the main nutritional issues in Brazil. PMID:28099649

  3. Relativity

    CERN Document Server

    Brewster, Hilary D

    2009-01-01

    The theory of relativity has become a cornerstone of modern physics. Over the course of time it has been scrutinized in a multitude of experiments and has always been verified with high accuracy. The correctness of this theory can no longer be called into question. Right after its discovery by Albert Einstein in 1905, special relativity was only gradually accepted because it made numerous predictions contradicting common sense, fervently castigated by Einstein, and also defied experiment for too long a time. It was only with the advent of particle or high energy physics that matter could be ac

  4. Relativity

    CERN Document Server

    Einstein, Albert

    2013-01-01

    Time magazine's ""Man of the Century"", Albert Einstein is the founder of modern physics and his theory of relativity is the most important scientific idea of the modern era. In this short book, Einstein explains, using the minimum of mathematical terms, the basic ideas and principles of the theory that has shaped the world we live in today. Unsurpassed by any subsequent books on relativity, this remains the most popular and useful exposition of Einstein's immense contribution to human knowledge.With a new foreword by Derek Raine.

  5. Saúde, direito à saúde e justiça sanitária

    Directory of Open Access Journals (Sweden)

    João Arriscado Nunes

    2012-10-01

    Full Text Available Propõe‑se uma abordagem preliminar dos processos heterogéneos e contingentes através dos quais se definem e constituem mutuamente a saúde e o direito à saúde. São apresentadas e discutidas duas manifestações recentes dessa dinâmica. A primeira situa‑se na linha das transformações associadas às orientações de inspiração neoliberal no campo da saúde, apontando para a passagem da saúde como direito à saúde como imperativo, centrado na responsabilização individual e na centralidade da vigilância e da prevenção. A segunda, designada justiça sanitária, é exemplificada através de situações em que cidadãos, através da acção colectiva e mobilizando os vocabulários dos direitos e da justiça, procuram o reconhecimento como portadores de uma doença, os direitos associados a essa condição e a acção pública sobre situações que afectam a sua saúde.

  6. Improvements in methods for monitoring anchor casings in mining excavations of KGHM Polska Miedź S.A. mines

    Directory of Open Access Journals (Sweden)

    Maciej Madziarz

    2016-01-01

    Full Text Available This article presents the results of works carried out by KGHM CUPRUM Sp z o.o. CBR (Research and Development Centre, on behalf of KGHM Polska Miedź SA. It is aimed at improving previously used monitoring methods of mine excavation anchor casings used in underground copper ore mines of KGHM Polska Miedź S.A. It presents a method allowing for continuous measurement and recording of load changes in instrumented anchors. This method was developed by request of KGHM Polska Miedź S.A. Particular attention was paid to issues related to the impact of dynamic changes of rock formation pressure on the excavation in anchor casing.

  7. Reentrainment Impairs Spatial Working Memory until Both Activity Onset and Offset Reentrain.

    Science.gov (United States)

    Ruby, Norman F; Patton, Danica F; Bane, Shalmali; Looi, David; Heller, H Craig

    2015-10-01

    Compression of the active phase (α) during reentrainment to phase-shifted light-dark (LD) cycles is a common feature of circadian systems, but its functional consequences have not been investigated. This study tested whether α compression in Siberian hamsters (Phodopus sungorus) impaired their spatial working memory as assessed by spontaneous alternation (SA) behavior in a T-maze. Animals were exposed to a 1- or 3-h phase delay of the LD cycle (16 h light/8 h dark). SA behavior was tested at 4 multiday intervals after the phase shift, and α was quantified for those days. All animals failed at the SA task while α was decompressing but recovered spatial memory ability once α returned to baseline levels. A second experiment exposed hamsters to a 2-h light pulse either early or late at night to compress α without phase-shifting the LD cycle. SA behavior was impaired until α decompressed to baseline levels. In a third experiment, α was compressed by changing photoperiod (LD 16:8, 18:6, 20:4) to see if absolute differences in α were related to spatial memory ability. Animals performed the SA task successfully in all 3 photoperiods. These data show that the dynamic process of α compression and decompression impairs spatial working memory and suggests that α modulation is a potential biomarker for assessing the impact of transmeridian flight or shift work on memory.

  8. Reentrainment impairs spatial working memory until both activity onset and offset reentrain

    Science.gov (United States)

    Ruby, Norman F.; Patton, Danica F.; Bane, Shalmali; Looi, David; Heller, H. Craig

    2016-01-01

    Compression of the active phase (α) during reentrainment to phase-shifted light-dark (LD) cycles is a common feature of circadian systems, but its functional consequences have not been investigated. This study tested whether α compression in Siberian hamsters (Phodopus sungorus) impaired their spatial working memory as assessed by spontaneous alternation (SA) behavior in a T-maze. Animals were exposed to a 1- or 3-h phase delay of the LD cycle (16 h light: 8 h dark). SA behavior was tested at four multi-day intervals after the phase shift and α was quantified for those days. All of the animals failed at the SA task while α was decompressing, but recovered spatial memory ability once α returned to baseline levels. A second experiment exposed hamsters to a 2-h light pulse either early or late at night to compress α without phase-shifting the LD cycle. SA behavior was impaired until α decompressed to baseline levels. In a third experiment, α was compressed by changing photoperiod (LD 16:8, 18:6, 20:4) to see if absolute differences in α were related to spatial memory ability. Animals performed the SA task successfully in all three photoperiods. These data show that the dynamic process of α compression and decompression impairs spatial working memory and suggests that α modulation is a potential biomarker for assessing the impact of transmeridian flight or shift work on memory. PMID:26224657

  9. Surface and atmospheric controls on the onset of moist convection over land

    NARCIS (Netherlands)

    Gentine, P.; Holtslag, A.A.M.; Andrea, D' F.; Ek, M.

    2013-01-01

    The onset of moist convection over land is investigated using a conceptual approach with a slab boundary layer model. We here determine the essential factors for the onset of boundary layer clouds over land, and study their relative importance. They are: 1) the ratio of the temperature to the moistu

  10. Early-onset preeclampsia : Constitutional factors and consequences for future pregnancy outcome and cardiovascular health

    NARCIS (Netherlands)

    van Rijn, B.B.

    2008-01-01

    In this thesis, maternal constitutional factors related to long-term cardiovascular health and subsequent pregnancy outcome in women with early-onset preeclampsia is addressed. Aims of the thesis: To evaluate subsequent pregnancy outcome in women with a first pregnancy complicated by early-onset

  11. Comparison of risk factors for the onset and maintenance of depression

    NARCIS (Netherlands)

    Bottomley, Christian; Nazareth, Irwin; Torres-Gonzalez, Francisco; Svab, Igor; Maaroos, Heidi-Ingrid; Geerlings, Mirjam I.; Xavier, Miguel; Saldivia, Sandra; King, Michael

    2010-01-01

    Background Factors associated with depression are usually identified from cross-sectional studies. Aims We explore the relative roles of onset and recovery in determining these associations. Method Hazard ratios for onset and recovery were estimated for 39 risk factors from a cohort study of 10045 g

  12. Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

    NARCIS (Netherlands)

    E. Kruithof; V. van den Bossche; L. de Rycke; B. Vandooren; R. Joos; J.D. Canete; P.P. Tak; A.M.H. Boots; E.M. Veys; D. Baeten

    2006-01-01

    Objective. To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA). Methods. Synovial biopsy samples were obtained from 10 patients with juvenile-onset SpA, 23 with adult SpA, 19 w

  13. Early-onset preeclampsia : Constitutional factors and consequences for future pregnancy outcome and cardiovascular health

    NARCIS (Netherlands)

    van Rijn, B.B.

    2008-01-01

    In this thesis, maternal constitutional factors related to long-term cardiovascular health and subsequent pregnancy outcome in women with early-onset preeclampsia is addressed. Aims of the thesis: To evaluate subsequent pregnancy outcome in women with a first pregnancy complicated by early-onset pre

  14. Functional impairments at school age of preterm born children with late-onset sepsis

    NARCIS (Netherlands)

    van der Ree, Meike; Tanis, Jozien C.; Van Braeckel, Koenraad N. J. A.; Bos, Arend F.; Roze, Elise

    2011-01-01

    Background: Late-onset sepsis is a relatively common complication particularly of preterm birth that affects approximately a quarter of very low birth weight infants. Aim: We aimed to determine the motor, cognitive, and behavioural outcome at school age of preterm children with late-onset sepsis com

  15. Differential labour market impacts from disability onset.

    Science.gov (United States)

    Polidano, Cain; Vu, Ha

    2015-03-01

    We estimate the causal labour market impacts of disability onset by gender, age and education levels up to 4 years after onset using longitudinal data from the Household Income and Labour Dynamics Australia survey and difference-in-difference propensity score matching techniques. We find lasting negative impacts on employment, especially full-time employment, which is due more to reduced movement into full-time employment than downshifting from full-time to part-time work following onset. Those without post-school education qualifications are particularly vulnerable to the impacts of onset and are more likely to be out of work and on income support than those with qualifications up to 4 years after onset, due in part because they have greater difficulty adjusting.

  16. Revista de Saúde Pública: 50 years disseminating the knowledge in nutrition.

    Science.gov (United States)

    Sichieri, Rosely; Pereira, Rosangela A

    2016-12-22

    This work describes and comments on articles in the area of Public Health Nutrition published in Revista de Saúde Pública (RSP - Public Health Journal) from 1967 to 2016. We searched in the PubMed database restricted to the periodical "Revista de Saúde Pública" and using terms related to key topics in the area of Public Health Nutrition. We retrieved 742 articles and, after exclusion of duplicates and articles unrelated to the subject, we analyzed 441 articles, grouped according to subject: dental caries, anemia, hypovitaminosis A, macro/micronutrients, malnutrition, nutritional assessment, overweight/obesity, food consumption, low birthweight, and breastfeeding. We observed significant increase in the number of articles published and diversification of subjects addressed over the 50 years, representing the consistent development of the scientific field of Nutrition in Brazil. Since its inception, RSP has played an important role in the dissemination of knowledge about the main nutritional issues in Brazil. RESUMO Este trabalho descreve e comenta os artigos na área de Nutrição em Saúde Pública, publicados na Revista de Saúde Pública (RSP) de 1967 a 2016. Foi realizada busca na base de dados PubMed restrita ao periódico "Revista de Saúde Pública" e utilizando termos relacionados com temáticas chaves da área de Nutrição em Saúde Pública. Foram recuperados 742 artigos e, após as exclusões dos artigos repetidos e daqueles não relacionados com a temática, foram analisados 441 artigos, agrupados segundo o tema: cárie dental, anemia, hipovitaminose A, macro/micronutrientes, desnutrição, avaliação do estado nutricional, sobrepeso/obesidade, consumo de alimentos, baixo peso ao nascer, e aleitamento materno. Observou-se incremento significativo no número de artigos publicados e a diversificação dos temas tratados ao longo destes 50 anos, retratando o consistente desenvolvimento do campo científico da Nutrição no Brasil. Desde seu início, a

  17. Psicologia e saúde: desafios atuais Psychology and health: recent challenges

    Directory of Open Access Journals (Sweden)

    Fernando González Rey

    1997-01-01

    Full Text Available Este artigo apresenta e discute diferentes desafios que a psicologia tem que enfrentar em seus estudos sobre assuntos relacionados com a saúde, que, sobre o ponto de vista do autor, são impossíveis de desenvolver com os estudos atuais sobre saúde e psicologia clínica. O autor enfatiza desafios concretos: o primeiro que é colocado está relacionado com a elaboração teórica do conceito de saúde, que tem sido praticamente ignorado na literatura psicológica, a qual tem se centrado no problema da doença. Neste sentido, o autor propõe abandonar a definição de saúde em termos de normalidade, equilíbrio ou ausência de sintomas. Para este propósito, o autor utiliza o conceito de distress e o explica com diferente enquadramento teórico, levando em conta sua complexa constituição subjetiva e social no curso da vida do sujeito. O outro desafio coloca a necessidade de incluir o problema da saúde entre outros já desenvolvidos pelas psicologias social e educacional, enfatizando a importância de um estudo intradisciplinar do problema da saúde em psicologia.This paper presents and discusses different challenges that psychology has to face in its approach to health issues, which, from my point of view, are impossible to develop within the current approaches to health and clinical psychology. I emphasize concrete challenges: the first deals with the theoretical elaboration of the concept of health, which has been practically ignored in the psychological literature that focus mostly on the matter of disease. In this sense, I propose to abandon the definition of health in terms of normality, equilibrium, or absence of symptoms. For this purpose, I take the concept of distress and explain it within a different theoretical framework, taking into account its complex subjective and social constitution on the subject’s life course. The other challenges relate to the need to include the matter of health among those developed by social and

  18. Ang Demokratikong Sistema at ang mga Modelo ng Pamumuno sa Pilipinas

    Directory of Open Access Journals (Sweden)

    F. P. A. Demeterio

    2010-06-01

    Full Text Available Maraming paraan ang pagsusuri sa problema ng pulitika sa Pilipinas.Para sa mga moralista at ideyalista, halimbawa, maaari itong tingnangamit ang perspektibo ng sistema ng pagpapahalaga (values at moralidad; para sa mga materyalista naman, maaari din itong himayin gamit ang perspektibo ng pagka-di-pantay-pantay ng kayamanan at kapangyarihan(unequal wealth and power ng ating mga mamamayan; o hindi kaya para sa mga eksperto sa sistema at istraktura, maaari din itong dalumatin gamit ang perspektibo ng ating marupok na burukrasya. Susubukan ng papel na ito na pag-aralan ang paksa sa pamamagitan ng pagsusuri sa konsepto ng pamumuno na hinihiling ng ating demokratikong sistema at sa kaparehong konseptong umiiiral naman sa kamalayan ng ating mga kababayan. Gagamitin ng pagsusuring ito, bilang teoretikal na balangkas, ang isang uri ng antropolohikalna teorya at pamamaraan na kilala bilang “kognitibong antropolohiya”(cognitive anthropology.

  19. Clincial analysis of the relative onset factors of 120 cases of ectopic pregnancy%120例异位妊娠发病相关因素的临床分析

    Institute of Scientific and Technical Information of China (English)

    任英俊

    2011-01-01

    目的 探讨异位妊娠的发病相关因素及治疗方法,为生育健康和保健工作提供科学依据.方法 回顾性分析2006年7月至2010年5月本院收治的120例异位妊娠患者的临床资料.结果 壶腹部妊娠较其他部位输卵管妊娠比例明显增高(P0.05).结论 异位妊娠的致病因素复杂,盆腔炎性病变、流产史、宫内节育器史、异位妊娠史是异位妊娠发生的危险因素.%Objective To investigate the incidence of ectopic pregnancy-related factors and treatment,and provide scientific basis for reproductive health and health care. Methods Retrospective analysis from July 2006 to May 2010,120 cases of ectopic pregnancy treated patients with clinical information.Results The rate of ectopic pregnancy in the ampullae of oviduct was markedly higher than that in other part of oviduct(P0.05).Conclusions The ectopic pregnancy risk factors is complex,including pelvic inflammatory disease, abortion, IUD and ectopic pregnancy history.

  20. The Indian Summer Monsoon onset revisited: new approach based on the analysis of historical wind observations

    Science.gov (United States)

    Ordoñez, Paulina; Gallego, David; Ribera, Pedro; Peña-Ortiz, Cristina; Garcia-Herrera, Ricardo; Vega, Inmaculada; Gómez, Francisco de Paula

    2016-04-01

    1940 and 1965 have been found. Our results show a relatively stable link between the ENSO cycle and the onset date; however this relationship is weaker in decades characterized by prevalent La Niña conditions. Furthermore, it was found that the link between the Pacific Decadal Oscillation (PDO) and the onset date is limited to the phases characterized by a shift from negative to positive PDO phases. This research was funded by the Spanish Ministerio de Economía y Competitividad through the projects CGL2013-44530-P and CGL2014-51721-REDT

  1. Impact of seizure frequency reduction on health-related quality of life among clinical trial subjects with refractory partial-onset seizures: A pooled analysis of phase III clinical trials of eslicarbazepine acetate.

    Science.gov (United States)

    Velez, Fulton F; Bond, T Christopher; Anastassopoulos, Kathryn P; Wang, Xuezhe; Sousa, Rui; Blum, David; Cramer, Joyce A

    2017-03-01

    Subjects who received eslicarbazepine acetate (ESL) as adjunctive therapy experienced significantly greater seizure frequency reduction (SFR) than placebo in three phase III, randomized, double-blind trials. This analysis compared changes in health-related quality of life (HRQOL) between treatment responders and non-responders across the pooled, per-protocol population (N=842) using the validated Quality of Life in Epilepsy Inventory-31 (QOLIE-31). QOLIE-31 scores were calculated for Total Score (TS) and seven subscales; higher scores indicate better HRQOL. Mean changes from baseline were calculated. Analysis of covariance examined least square mean (LSM) differences in final scores between responders (≥50% and ≥75% SFR) and non-responders. Clinical significance was based on established minimal clinically important differences (MCIDs). Mean changes were greater among responders for TS (5.2 versus 1.4 for ≥50% SFR; 7.5 versus 1.9 for ≥75% SFR) and all subscales. Additionally, the percentage of subjects with changes meeting or exceeding MCIDs was higher among responders for TS (48.4% versus 33.9% for ≥50% SFR; 56.9% versus 35.8% for ≥75% SFR) and all subscales. Responders had significantly higher final scores for TS (LSM difference=4.0 for ≥50% SFR; LSM difference=5.7 for ≥75% SFR) and all subscales except emotional well-being at ≥50% SFR. LSM differences exceeded MCIDs at ≥75% SFR for TS and five of seven subscales, and two subscales at ≥50% SFR. In a subgroup analysis with placebo removed, LSM differences were larger overall. In clinical trials of adjunctive ESL, higher levels of SFR were associated with greater improvements in HRQOL. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Abandono do tratamento de tuberculose e relações de vínculo com a equipe de saúde da família Abandono del tratamiento de la tuberculosis e relaciones vinculares con el equipo de salud familiar Tuberculosis treatment drop out and relations of bonding to the family health team

    Directory of Open Access Journals (Sweden)

    Káren Mendes Jorge de Souza

    2010-12-01

    Full Text Available A pesquisa objetivou analisar a relação entre as singularidades do doente com história de abandono do tratamento de tuberculose e a atenção dispensada pela equipe de saúde da família à luz do conceito de vínculo. A construção do material empírico deu-se por meio de entrevistas gravadas, no período de julho a setembro de 2008, utilizando-se a História Oral Temática. Foram entrevistados nove usuários que tiveram o abandono como critério de encerramento para o tratamento da tuberculose em dois municípios da região metropolitana de João Pessoa, Paraíba, Brasil. O estudo foi realizado conforme a técnica da análise do discurso. Identificou-se que uma relação terapêutica, com partilha de compromissos e valorização do usuário, fortalece o vínculo e produz a democratização da gestão do cuidado. Por outro lado, uma relação vertical, com vínculo fragilizado, opõe-se ao propósito de uma prática inter-subjetiva na perspectiva da co-gestão do cuidado.La investigación objetivó analizar la relación entre las singularidades del enfermo con historial de abandono del tratamiento de la tuberculosis y la atención dispensada por el equipo de salud familiar a la luz del concepto vincular. La construcción del material empírico se realizó a través de entrevistas grabadas, en el período de julio a setiembre de 2008, utilizándose la Historia Oral Temática. Fueron entrevistados nueve usuarios que consideraron al abandono como criterio de cierre para el tratamiento de la tuberculosis, en dos municipios de la región metropolitana de João Pessoa, Paraíba, Brasil. El análisis se realizó de acuerdo a la técnica de análisis del discurso. Se identificó que una relación terapéutica, con reparto de compromisos y valorización del usuario, fortalece el vínculo y produce una democratización de la gestión de atención. Asimismo, una relación vertical, con vínculo fragilizado, se opone al propósito de una pr

  3. Diagnosing young onset dementia can be challenging.

    Science.gov (United States)

    Ahmed, Samrah; Baker, Ian; Butler, Christopher R

    2016-05-01

    Although the risk of developing dementia increases with age, onset can be as early as the third or fourth decade of life. Genetic influences play a more important role in younger than in older people with dementia, so young onset dementia may cluster in families. Diagnosing young onset dementia is challenging. The range of possible presenting features is broad, encompassing behavioural, cognitive, psychiatric and neurological domains, and symptoms are often subtle initially. Frequently the complaints are misattributed to stress or depression, and the patient is falsely reassured that they are too young to have dementia. The most common causes of young onset dementia are early onset forms of adult neurodegenerative conditions and alcohol. Vascular dementia is the second most common cause of young onset dementia after Alzheimer's disease. Conventional vascular risk factors may be absent and diagnosis relies on imaging evidence of cerebrovascular disease. Obtaining a detailed history remains the most important part of the workup and usually requires corroboration by a third party. Undertaking a basic neurological examination is also important. Those with suspected young onset dementia should be referred to a neurology-led cognitive disorders clinic where available as the differenti diagnosis is considerably broader tha in older adults and requires specialist investigation.

  4. Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.

    Directory of Open Access Journals (Sweden)

    David J Cutler

    Full Text Available The inflammatory bowel diseases (IBD are common, complex disorders in which genetic and environmental factors are believed to interact leading to chronic inflammatory responses against the gut microbiota. Earlier genetic studies performed in mostly adult population of European descent identified 163 loci affecting IBD risk, but most have relatively modest effect sizes, and altogether explain only ~20% of the genetic susceptibility. Pediatric onset represents about 25% of overall incident cases in IBD, characterized by distinct disease physiology, course and risks. The goal of this study is to compare the allelic architecture of early onset IBD with adult onset in population of European descent.We performed a fine mapping association study of early onset IBD using high-density Immunochip genotyping on 1008 pediatric-onset IBD cases (801 Crohn's disease; 121 ulcerative colitis and 86 IBD undetermined and 1633 healthy controls. Of the 158 SNP genotypes obtained (out of the 163 identified in adult onset, this study replicated 4% (5 SNPs out of 136 of the SNPs identified in the Crohn's disease (CD cases and 0.8% (1 SNP out of 128 in the ulcerative colitis (UC cases. Replicated SNPs implicated the well known NOD2 and IL23R. The point estimate for the odds ratio (ORs for NOD2 was above and outside the confidence intervals reported in adult onset. A polygenic liability score weakly predicted the age of onset for a larger collection of CD cases (p< 0.03, R2= 0.007, but not for the smaller number of UC cases.The allelic architecture of common susceptibility variants for early onset IBD is similar to that of adult onset. This immunochip genotyping study failed to identify additional common variants that may explain the distinct phenotype that characterize early onset IBD. A comprehensive dissection of genetic loci is necessary to further characterize the genetic architecture of early onset IBD.

  5. Cutaneous warming promotes sleep onset

    National Research Council Canada - National Science Library

    Roy J. E. M. Raymann; Dick F. Swaab; Eus J. W. Van Someren

    2005-01-01

    Sleep occurs in close relation to changes in body temperature. Both the monophasic sleep period in humans and the polyphasic sleep periods in rodents tend to be initiated when core body temperature is declining...

  6. Speech disorders did not correlate with age at onset of Parkinson's disease.

    Science.gov (United States)

    Dias, Alice Estevo; Barbosa, Maira Tonidandel; Limongi, João Carlos Papaterra; Barbosa, Egberto Reis

    2016-02-01

    Speech disorders are common manifestations of Parkinson´s disease. Objective To compare speech articulation in patients according to age at onset of the disease. Methods Fifty patients was divided into two groups: Group I consisted of 30 patients with age at onset between 40 and 55 years; Group II consisted of 20 patients with age at onset after 65 years. All patients were evaluated based on the Unified Parkinson's Disease Rating Scale scores, Hoehn and Yahr scale and speech evaluation by perceptual and acoustical analysis. Results There was no statistically significant difference between the two groups regarding neurological involvement and speech characteristics. Correlation analysis indicated differences in speech articulation in relation to staging and axial scores of rigidity and bradykinesia for middle and late-onset. Conclusions Impairment of speech articulation did not correlate with age at onset of disease, but was positively related with disease duration and higher scores in both groups.

  7. 20-Hydroxyecdysone activates PGRP-SA mediated immune response in Locusta migratoria.

    Science.gov (United States)

    Han, Pengfei; Han, Jiao; Fan, Jiqiao; Zhang, Min; Ma, Enbo; Li, Sheng; Fan, Renjun; Zhang, Jianzhen

    2017-02-27

    20-hydroxyecdysone (20E) has been implicated in regulating the immune response in insects. Conflicting conclusions on 20E regulating immunity have been reported in model holometabolous species. However, in hemimetabolous insects, the role of 20E as an immune-suppressor or activator and the mechanism remains unclear. The migratory locust Locusta migratoria is a representative member of hemimetabolous insects. Here, digital gene expression (DGE) profiles of Locusta migratoria treated with 20E were analyzed. Pattern recognition receptors [peptidoglycan recognition protein (PGRP-SA), PGRP-LE, and gram-negative binding protein (GNBP3)] and antimicrobial peptides (defensin, diptericin, and i-type lysozyme) were significantly induced by 20E in fat body. These immune-related genes significantly increased their mRNA levels during the high-20E stage. Antibacterial activities in plasma were enhanced after 20E injection and during the high-20E developmental stage. Conversely, when 20E signal was suppressed by RNAi of EcR (ecdysone receptor), the expression levels of these genes and antibacterial activities failed to be increased by 20E injection and during the high-20E developmental stage, and the mortality increased after being infected by entomogenous fungus. The knockdown of PGRP-SA inhibited the expression level of defensin, diptericin and i-type lysozyme in fat body and reduced antibacterial activities in plasma. 20E injection could not significantly induce the expression of antimicrobial peptides after RNAi of PGRP-SA. These results demonstrated that 20E enhanced the immune response by activating PGRP-SA in L. migratoria.

  8. Tungo sa Hardin ng Tao: “Si Bonifacio ang pinakauna, hindi lamang sa Pilipinas, kundi sa buong Indonesia, oo, sa buong Asia na nanggaling sa, at edukado bilang, proletaryado, na nag-organisa ng mga proletaryo.” ni Tan Malaka

    Directory of Open Access Journals (Sweden)

    Ramon Guillermo

    2013-06-01

    Full Text Available Salin ito ng sanaysay na “Ke Taman Manusia” (sinulat taong 1943 nakathang-isip ng Indones na lider komunista na si Tan Malaka o Ibrahimgelar Datuk Tan Malaka (1897-1949 hinggil sa isang “Taman Manusia”o “Hardin ng Tao” na itatayo ng darating na Republika ng Indonesia sahinaharap. Dahil sa futuristiko nitong perspektiba, maihahalintuladang obrang ito ni Tan Malaka sa sanaysay ni Jose Rizal na “Filipinasdentro de cien años” (Ang Pilipinas sa loob ng isang dantaon (1891.Galing ito sa napakalaking akdang pilosopikal ni Tan Malaka napinamagatang Madilog: Materialisme, Dialektika, Logika (1948(Larawan 1 at tila tumatayo bilang pansarang mga repleksyon nito(Magnis-Suseno, 2005, pp. 205-233. Ang akdang ito ay unanginilathala noong 1951 ng Terbitan Widjaya sa Jakarta.

  9. Causes for Late onset Alcohol Use Disorder

    DEFF Research Database (Denmark)

    Emiliussen, Jakob; Nielsen, Anette Søgaard; Andersen, Kjeld

    the available literature on the subject. Method A PRISMA style review and search was performed in late May 2014 and covered MEDLINE, EMBASE, PubMed, and PsychInfo. Inclusion was based on if the study had causes for late-onset AUD in their results section. This revealed 24 articles relevant for this study. After...... not increase the risk for late-onset AUD. However, the data was insufficient to give a reliable quantification of these associations. Discussion A common problem for the studies included (and the ones excluded as well) was the lack of common definitions of late-onset, “stress” and “traumatic life events...

  10. Estratégia de apoio em saúde mental aos agentes comunitários de saúde de Salvador-BA Strategy for supporting community health agents in mental health actions in Salvador-BA

    Directory of Open Access Journals (Sweden)

    Cristiane Batista da Silva

    2012-03-01

    Full Text Available Este artigo descreve uma intervenção de apoio matricial, modelo de integração do cuidado em saúde mental na Estratégia de Saúde da Família (ESF, a partir de suporte técnico-pedagógico e retaguarda especializada à equipe de referência, cuja atuação permite que os sujeitos sejam cuidados na dinâmica do seu próprio território. OBJETIVO: relatar experiência de apoio matricial junto aos Agentes Comunitários de Saúde no bairro de Saramandaia (Salvador, Bahia que buscou formular novas formas de relação entre saúde mental e saúde da família. PROCEDIMENTOS METODOLÓGICOS: A experiência resultou de uma pesquisa, intitulada "Construção social da aprendizagem em saúde mental e saúde da família" e dos contatos com a equipe; nela foram respeitados três cuidados essenciais da pesquisa qualitativa: aprovação pelo comitê de ética, anonimato e resguardo do uso abusivo do poder na relação entre pesquisador e participantes. Para o matriciamento, foram realizadas reuniões teóricas, discussão de casos e visitas domiciliares. RESULTADOS: O apoio matricial propiciou a construção coletiva de saberes em saúde mental, garantiu espaço de cuidado aos Agentes Comunitários de Saúde e fomentou a construção de redes do cotidiano, estimulando a articulação entre saúde mental e saúde da família de forma a favorecer o exercício da cidadania e a autonomia dos sujeitos sobre sua própria saúde.This paper describes an intervention offering matrix support, a model for integrating mental health care in Family Health Strategy (FHS. In this model, technical-pedagogical and specialized services are offered to the primary care team, helping them to provide care to the patients in the dynamics of their own territory. OBJECTIVE: To report the experience of offering matrix support to Community Health Agents in the district of Saramandaia (Salvador, Bahia, which tried to formulate new possible relations between mental health and family

  11. A method for determining the onset year of intense browsing

    Science.gov (United States)

    Keigley, R.B.; Frisina, M.R.; Fager, C.

    2003-01-01

    A survey based on browsing related architectures indicated that browsing level had increased at the Mt. Haggin Wildlife Management Area. We describe a technique for determining the year in which the increase in browsing level occurred. The technique is based on the analysis of stems old enough to have experienced the early period of light browsing; the onset year of intense browsing was determined by using dendrochronology to date the formation of twig clusters produced by intense browsing. Stems from 20 Geyer willow (Salix geyeriana Anderss.) plants were analyzed from each of 6 study sites. Mean onset years at the 6 sites ranged from 1983.1 to 1988.4; the mean onset year for all 6 sites was 1985.4 ?? 0.5 SE (N = 120). The reconstructed history was used to evaluate the relationship between moose (Alces alces) number and browse trend. From 1976 to 2000, the winter trend census of moose increased from 7 to 56. The onset of intense browsing in 1985 occurred when 23 moose were counted.

  12. Neuro-Music Therapy for Recent-Onset Tinnitus

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    Miriam Grapp

    2013-05-01

    Full Text Available The aim of this pilot study was the evaluation of the neuro-music therapy approach as a new treatment option for patients with recent-onset tinnitus whose tinnitus symptoms were enduring after initial pharmacological treatment. In all, 15 patients with recent-onset tinnitus took part in our manualized short-term music-therapeutic treatment. Tinnitus severity and individual tinnitus distress were assessed by the German version of the tinnitus questionnaire (TQ and the Attention and Performance Self-Assessment Scale (APSA at three different measurement times: baseline (T0, start of treatment (T1, and end of treatment (T2. Score changes in TQ and APSA from start to end of treatment indicated significant improvements in tinnitus-related distress. According to the Jacobson and Truax reliable change index (RC, 73.3% of the patients showed a reliable reduction in individual TQ-score. The neuro-music therapy for recent-onset tinnitus according to the “Heidelberg Model” introduced in this pilot study seems to provide an effective treatment option for patients with recent-onset tinnitus.

  13. Does tinnitus distress depend on age of onset?

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    Winfried Schlee

    Full Text Available OBJECTIVES: Tinnitus is the perception of a sound in the absence of any physical source of it. About 5-15% of the population report hearing such a tinnitus and about 1-2% suffer from their tinnitus leading to anxiety, sleep disorders or depression. It is currently not completely understood why some people feel distressed by their tinnitus, while others don't. Several studies indicate that the amount of tinnitus distress is associated with many factors including comorbid anxiety, comorbid depression, personality, the psychosocial situation, the amount of the related hearing loss and the loudness of the tinnitus. Furthermore, theoretical considerations suggest an impact of the age at tinnitus onset influencing tinnitus distress. METHODS: Based on a sample of 755 normal hearing tinnitus patients we tested this assumption. All participants answered a questionnaire on the amount of tinnitus distress together with a large variety of clinical and demographic data. RESULTS: Patients with an earlier onset of tinnitus suffer significantly less than patients with an onset later in life. Furthermore, patients with a later onset of tinnitus describe their course of tinnitus distress as more abrupt and distressing right from the beginning. CONCLUSION: We argue that a decline of compensatory brain plasticity in older age accounts for this age-dependent tinnitus decompensation.

  14. Transient cortical excitation at the onset of visual fixation.

    Science.gov (United States)

    Rajkai, Csaba; Lakatos, Peter; Chen, Chi-Ming; Pincze, Zsuzsa; Karmos, Gyorgy; Schroeder, Charles E

    2008-01-01

    Primates actively examine the visual world by rapidly shifting gaze (fixation) over the elements in a scene. Despite this fact, we typically study vision by presenting stimuli with gaze held constant. To better understand the dynamics of natural vision, we examined how the onset of visual fixation affects ongoing neuronal activity in the absence of visual stimulation. We used multiunit activity and current source density measurements to index neuronal firing patterns and underlying synaptic processes in macaque V1. Initial averaging of neural activity synchronized to the onset of fixation suggested that a brief period of cortical excitation follows each fixation. Subsequent single-trial analyses revealed that 1) neuronal oscillation phase transits from random to a highly organized state just after the fixation onset, 2) this phase concentration is accompanied by increased spectral power in several frequency bands, and 3) visual response amplitude is enhanced at the specific oscillatory phase associated with fixation. We hypothesize that nonvisual inputs are used by the brain to increase cortical excitability at fixation onset, thus "priming" the system for new visual inputs generated at fixation. Despite remaining mechanistic questions, it appears that analysis of fixation-related responses may be useful in studying natural vision.

  15. Neuromyelitis optica with onset in childhood and adolescence.

    Science.gov (United States)

    Fragoso, Yara Dadalti; Ferreira, Maria L B; Oliveira, Enedina M L; Domingues, Renan B; Ribeiro, Taysa A G J; Brooks, Joseph B B; Claudino, Rinaldo; Netto, Jussara M K; Gomes, Sidney; Adoni, Tarso; Carneiro, Denise S D; Fonseca, Daiana R P; Fragomeni, Manuela O; Oliveira, Francisco T M; Oliveira, Celso L S; Saldanha, Patricia C O; Souza, Jorge M B

    2014-01-01

    Neuromyelitis optica with onset before the age of 18 years is a relatively rare, yet potentially devastating condition. The objective of the present study was to contribute to the study of early-onset neuromyelitis optica with a case series. Data were collected from medical records of Brazilian neurologists caring for patients with neuromyelitis optica occurring in childhood and adolescence. Twenty-nine patients with neuromyelitis optica occurring before the age of 18 years and fulfilling the diagnostic criteria were identified. The average age at disease onset was 13 years and the patients had had an average disease duration of 6 years. The expanded disability scale score at the latest consultation was, on average, 4.7, and one patient had died from the disease. The 29 patients had had an average 4.5 relapses during the disease, accounting for 0.75 relapses per year, irrespective of the medication used. All patients were using one or more of the following medications: azathioprine, prednisone, immunoglobulin, and glatiramer acetate. Neuromyelitis optica with onset in childhood and adolescence is a poorly understood condition that is often disabling and difficult to manage. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Critérios adotados para seleção de indicadores de contaminação ambiental relacionados aos resíduos sólidos de serviços de saúde: uma proposta de avaliação Criteria for definition of environmental contamination indicators related to solid waste from health care facilities: a proposal for evaluation

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    Aída Cristina do Nascimento Silva

    2002-10-01

    Full Text Available O objetivo deste estudo é identificar microrganismos indicadores de contaminação ambiental, a partir dos principais aspectos ambientais e cadeia epidemiológica relacionados aos agentes. A seleção dos microrganismos a serem definidos como indicadores foi realizada a partir de informações específicas sobre a caracterização microbiológica de resíduos sólidos de serviços de saúde (RSSS, e a avaliação de riscos de infecção pelos materiais perfurocortantes presentes nesses resíduos. A forma de avaliação proposta para os critérios adotados na seleção de indicadores de contaminação abrangeu entrega prévia de questionário estruturado a uma rede de especialistas do Distrito Federal. A formação multidisciplinar dos especialistas, composta por profissionais da área de saúde e microbiologista ambiental, permitiu definir, de forma consensual, os indicadores de contaminação ambiental. Patógenos como Mycobacterium tuberculosis e os vírus da Hepatite A e B destacam-se no estudo com capacidade de sobrevivência ou resistência ambiental.The objective of this study was to identify target microorganisms as indicators of environmental contamination. The study evaluates the main environmental aspects and epidemiological chain related to such agents. Microorganisms were selected through key information about microbiological characterization of health care facilities' solid waste and evaluation of risk of infection from discarded sharps. The form of evaluation proposed for criteria adopted in the selection of contamination indicators included prior submission of a structured questionnaire to a network of specialists from the Federal District of Brazil. The specialists' multidisciplinary background, including professionals from the health field and an environmental microbiologist, helped define environmental contamination indicators by consensus. Pathogens such as Mycobacterium tuberculosis and hepatitis A and B viruses were

  17. Bacillus licheniformis SA03 Confers Increased Saline–Alkaline Tolerance in Chrysanthemum Plants by Induction of Abscisic Acid Accumulation

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    Cheng Zhou

    2017-06-01

    Full Text Available Soil saline-alkalization is a major abiotic stress that leads to low iron (Fe availability and high toxicity of sodium ions (Na+ for plants. It has recently been shown that plant growth promoting rhizobacteria (PGPR can enhance the ability of plants to tolerate multiple abiotic stresses such as drought, salinity, and nutrient deficiency. However, the possible involvement of PGPR in improving saline–alkaline tolerance of plants and the underlying mechanisms remain largely unknown. In this study, we investigated the effects of Bacillus licheniformis (strain SA03 on the growth of Chrysanthemum plants under saline–alkaline conditions. Our results revealed that inoculation with SA03 alleviated saline–alkaline stress in plants with increased survival rates, photosynthesis and biomass. The inoculated plants accumulated more Fe and lower Na+ concentrations under saline–alkaline stress compared with the non-inoculated plants. RNA-Sequencing analyses further revealed that SA03 significantly activated abiotic stress- and Fe acquisition-related pathways in the stress-treated plants. However, SA03 failed to increase saline–alkaline tolerance in plants when cellular abscisic acid (ABA and nitric oxide (NO synthesis were inhibited by treatment with fluridone (FLU and 2-(4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (c-PTIO, respectively. Importantly, we also found that NO acted downstream of SA03-induced ABA to activate a series of adaptive responses in host plants under saline–alkaline stress. These findings demonstrated the potential roles of B. licheniformis SA03 in enhancing saline–alkaline tolerance of plants and highlighted the intricate integration of microbial signaling in regulating cellular Fe and Na+ accumulation.

  18. Avaliação das condições de trabalho, treinamento, saúde e segurança de brigadistas de combate a incêndios florestais em unidades de conservação do Distrito Federal: estudo de caso Evaluation of job conditions and aspects related to training, health and safety of the forest fire crew members at Distrito Federal

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    Nilton César Fiedler

    2006-02-01

    Full Text Available Este estudo teve como objetivo avaliar as condições de trabalho, treinamento, saúde e segurança dos brigadistas de combate a incêndios florestais no Distrito Federal. A pesquisa foi realizada nas Unidades de Conservação da Fazenda Água Limpa, Reserva Ecológica do Instituto Brasileiro de Geografia e Estatística e Instituto Jardim Botânico de Brasília. A coleta de dados foi feita com a aplicação de um questionário em forma de entrevista individual. Participaram da avaliação todos os 53 brigadistas das Unidades de Conservação. De acordo com os resultados, a brigada do Jardim Botânico de Brasília tinha significativo porcentual de treinados (92,8%, todos com cursos de primeiros socorros, e um alto porcentual de trabalhadores com problemas de saúde (33,3%. Os brigadistas da Reserva Ecológica do IBGE exerciam, em sua grande maioria, o trabalho por gosto pela atividade (84,6%, eram bem treinados (92,3% e todos participaram de cursos de primeiros socorros, sendo o porcentual de acidentes o mais baixo (7,7%. Na brigada da Fazenda Água Limpa foram encontrados os menores porcentuais de treinados (39,1%, maiores porcentuais de acidentes (17,4%, menores porcentuais de pessoas que exerciam a função por gosto pela atividade (30,4% e menores porcentuais de pessoas com problemas de saúde (8,7%. A grande maioria dos brigadistas nas três Unidades de Conservação ressaltou a questão da necessidade de regulamentação das brigadas e atentou para a insatisfação quanto aos equipamentos de proteção individual utilizados e inadequada reposição.The objective of this work was to evaluate the job conditions and aspects related to training, health and safety of forest fire crew members at Distrito Federal. The work was carried out in some Protected Areas including Água Limpa Farm, Ecological Reserve of Brazilian Institute of Geography and Statistics (IBGE and Brasília Botanical Garden. The data was collected through individual interviews

  19. Medications Errors and Health-Related Quality of Life of Nursing Professionals in Intensive Care Units Errores de medicación y calidad de vida relacionada a la salud de profesionales de enfermería en Unidades de Terapia Intensiva Erros de medicação e qualidade de vida relacionada à saúde de profissionais de enfermagem em unidades de terapia intensiva

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    Josikélem da Silva Sodré Pelliciotti

    2010-12-01

    Full Text Available This study identifies the prevalence of medication errors in ICUs reported by nursing professionals, compares the health-related quality of life (HRQoL and health status changes of those professionals both involved and not involved with medication errors in ICUs. A total of 94 nursing professionals in three ICUs of a private hospital were studied: 39 (41.5% nurses and 55 (58.5% nursing technicians. HRQoL was assessed through the Portuguese version of the SF-36 instrument. Eighteen professionals (19.1% reported medication errors during the month prior to data collection. The errors were reported in 61.1% of the cases and the most frequent ones were those in the administration phase (67.8%. The professionals who reported medication errors displayed worse health conditions than those who did not report errors.Este estudio tuvo como objetivos: identificar la prevalencia de errores de medicación en UTI relatados por profesionales de enfermería; comparar la calidad de vida relacionada a la salud (CVRS y las alteraciones en el estado de salud de los profesionales envueltos y no envueltos con errores de medicación. Fueron investigados 94 profesionales de tres UTIs de un hospital privado, siendo 39 enfermeros (41,5% y 55 (58,5% técnicos de enfermería. La CVRS fue evaluada por la versión en portugués del instrumento SF-36. Dieciocho profesionales (19,1% mencionaron haber cometido errores en el mes anterior a la investigación. Los errores fueron notificados en 61,1% de los casos y los más frecuentes fueron los encontrados en la fase de administración (67,8%. Los profesionales que relataron errores de medicación tuvieron tendencia al peor estado de salud, cuando comparados a los que no relataron errores.Este estudo teve como objetivos identificar a prevalência de erros de medicação em unidades de terapia intensiva (UTI, relatados por profissionais de enfermagem, comparar a qualidade de vida relacionada à saúde (QVRS e as alterações no

  20. Fatores preditores da qualidade de vida relacionada à saúde física e mental em pacientes com doença pulmonar intersticial: uma análise multifatorial Predictors of physical and mental health-related quality of life in patients with interstitial lung disease: a multifactorial analysis

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    Ana Cláudia Coelho

    2010-10-01

    Full Text Available OBJETIVO: Avaliar fatores preditores da qualidade de vida relacionada à saúde (QVRS em pacientes com doença pulmonar intersticial (DPI. MÉTODOS: Estudo transversal com 63 pacientes, submetidos a provas de função pulmonar e teste de caminhada de seis minutos. Foram aplicados os seguintes instrumentos: Medical Outcomes Study 36-item Short-form Survey (SF-36, Saint George's Respiratory Questionnaire (SGRQ, os inventários de ansiedade e depressão de Beck e Modified Medical Research Council Dyspnea Scale. A análise de componentes principais foi utilizada para reduzir as variáveis em fatores preditivos, e a análise de regressão linear múltipla foi utilizada como um modelo explicativo. RESULTADOS: Dos 63 pacientes, 34 eram mulheres. A média de idade foi de 60,1 ± 13,3 anos, média de CVF = 64,17 ± 15,54% do previsto e média de DLCO = 44,21 ± 14,47% do previsto. Todos os pacientes avaliados tinham sua QVRS prejudicada, e os piores escores foram observados nos domínios capacidade funcional do SF-36 e atividade do SGRQ. Dos pacientes avaliados 60,3% e 57,1% apresentaram sintomas de ansiedade e depressão, respectivamente. A análise de componentes principais identificou um fator preditor para QVRS física e um fator preditor para QVRS mental. A depressão apresentou uma forte influência sobre o fator preditor de QVRS mental, e o grau de dispneia apresentou uma influência significativa sobre os dois fatores preditores de QVRS nos pacientes avaliados. Variáveis relacionadas à função pulmonar, capacidade de exercício e ansiedade não apresentaram impactos sobre esses fatores preditores. CONCLUSÕES: Em nossa amostra de pacientes com DPI, o grau de dispneia teve um impacto importante sobre a QVRS física e mental, e a depressão teve um impacto sobre a QVRS mental nos pacientes com DPI.OBJECTIVE: To determine predictors of health-related quality of life (HRQoL in patients with interstitial lung disease (ILD. METHODS: A cross

  1. SA8000标准的来历

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    社会道德责任标准Social Accoutability 8000或简称SA8000。自1997年问世以来,受到了公众极大的关注,在美欧工商界引起了强烈反响。专家们认为,SA8000是ISO9000、ISO14000之后出现的又一个重要的国际性标准,并迟早会转化为ISO标准;通过SA8000认证将成为国际市场竞争中的又一重要武器。有远见的组织家应未

  2. PET-Saúde: micropolítica, formação e o trabalho em saúde

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    Kathleen Tereza da Cruz

    2015-12-01

    Full Text Available O presente artigo analisa os efeitos que podem ser coletados das múltiplas experiências cotidianas vivenciadas pelos tutores/as, preceptores/as e alunos/as participantes do Programa de Educação pelo Trabalho para Saúde (PET-Saúde quando se trata de utilizá-las para se pensarem transformações na micropolítica da formação universitária e no trabalho em saúde. Tem como eixo uma pergunta: O Programa Pet-Saúde, nos seus processos cotidianos, é capaz de produzir efeitos que alargam a matriz de formação que tem como característica principal os processos de ensignação? Mais do que polarizar entre o sim e o não, temos como objetivo colocar em discussão as apostas na formação e atuação do campo da produção do cuidado em saúde, tentando pensar o que têm sido esses campos no âmbito da educação brasileira, e como é possível re-inventar processos de formação que tomam muito mais as desaprendizagens e as potencialidades dos diferentes atores envolvidos.

  3. Intervenções de enfermagem relacionadas à promoção da saúde em portadores de hipertensão Intervenciones de enfermería relacionadas a la promoción de la salud en portadores de hipertensión Nursing interventions related to health promotion in hypertensive patients

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    Nirla Gomes Guedes

    2012-01-01

    Full Text Available OBJETIVOS: Identificar as competências de promoção da saúde em intervenções de enfermagem em portadores de hipertensão arterial. MÉTODOS: Seguiu-se a metodologia de revisão integrativa da literatura, utilizando as oito competências para a prática de promoção da saúde definidas na Conferência de Galway. Foram analisados 16 artigos. RESULTADOS: Os domínios de competência para a prática de promoção da saúde mais evidenciados foram Catalisar mudanças, Avaliação das necessidades e Parcerias. Apenas um artigo mencionou o uso das taxonomias de enfermagem para o planejamento da assistência em portadores de hipertensão arterial. CONCLUSÃO: Os resultados deste estudo poderão subsidiar as competências dos enfermeiros para a prática da promoção da saúde em portadores de hipertensão arterial.OBJETIVOS: Identificar las competencias de promoción de la salud en intervenciones de enfermería en portadores de hipertensión arterial. MÉTODOS: Se siguió la metodología de La revisión integrativa de la literatura, utilizando las ocho competencias para la práctica de la promoción de la salud definidas en la Conferencia de Galway. Fueron analizados 16 artículos. RESULTADOS: Los dominios de competencia para la práctica de promoción de la salud más evidenciados fueron Catalizar cambios, Evaluación de las necesidades y sociedades. Sólo un artículo mencionó el uso de las taxonomías de enfermería para la planificación de la asistencia en portadores de hipertensión arterial. CONCLUSIÓN: Los resultados de este estudo pueden subsidiar las competencias de los enfermeros para la práctica de la promoción de la salud en portadores de hipertensión arterial.OBJECTIVES: To identify the health promotion compentencies of nursing interventions for patient with hypertension. METHODS: The methodology of an integrative literature review was followed, using the eight competencies for the practice of health promotion that were defined

  4. The experience of nurses at a family health unit in Londrina, and its relation to the responsibilities of the professional exercise As práticas das enfermeiras de uma unidade de saúde da família de Londrina, e a relação com as atribuições do exercício profissional

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    Mara Lúcia Rocha Ramos

    2008-10-01

    Full Text Available Discussions over nursing practices have been intensified and valued over the last few years, due to the need to know and discuss nursing competences and to provide support to the nursing activities carried out by the Family Health Unit (FHU. For this reason, not only knowing what their responsibilities are but also certifying whether they are connected with the reality of their jobs have become indispensable. A qualitative research, using a case study, was developed to analyze, from June 19 2006 to September 6 2006, the activities carried out by five nurses from the FHU of Londrina. The nursing attributions analyzed by this research were those established by the Ministry of Health and the County of Londrina Health Department. Results showed that, although the attributions of the nursing professional exercise are broad, they lead to realistic nursing practices, some being more usual than others. In addition, findings from this study showed that, assistance activities, among other attributions, prevailed with nurses from the Family Health Program (FHP, whereas administration and supervision activities are done by the senior nursing officer. It was concluded that these responsibilities cannot possibly be accomplished by only one nurse, and that a good team work is required, with nurses sharing their tasks, organizing diaries, planning and defining priorities for their practices. Estudar as práticas de enfermagem é um tema cuja discussão tem sido valorizada e intensificada nos últimos anos, devido à necessidade de se conhecer e esclarecer as competências e dar respaldo ao profissional enfermeiro das práticas realizadas nas Unidades de Saúde da Família (USF. Para isso, torna-se necessário não apenas ter o conhecimento dessas atribuições, mas também saber se todas estão de acordo com a realidade do trabalho desenvolvido por esses profissionais. Esta pesquisa tem uma abordagem qualitativa, tipo estudo de caso, que analisou, durante o per

  5. Sindicalismo, SUS e planos de saúde

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    José Augusto Pina

    Full Text Available Este artigo discute a interlocução do sindicalismo brasileiro com o Sistema Único de Saúde (SUS e os planos e seguros privados de saúde. São ponderadas algumas teses na Saúde Coletiva à luz de estudos mais recentes nas Ciências Sociais sobre o sindicalismo e realizada análise documental para o caso da Central Única dos Trabalhadores (CUT, tomado aqui como referência. Aponta-se a necessidade de considerar os pesos relativos que a ação sindical atribuiu a cada um dos aspectos da relação, SUS e planos privados de saúde, pelas distintas conjunturas do país. O conflito entre trabalhadores e empresas somado ao desemprego e à precarização do trabalho expõe os limites das coberturas assistenciais privadas e impele a representação sindical a pleitear a intervenção estatal. O trabalho refletiu sobre as distintas modalidades de ação sindical na empresa e no Estado. A complexidade dessa dinâmica fez emergir um setor sindical interessado na gestão da previdência complementar e dos planos de saúde e, ao mesmo tempo, recria as circunstâncias e traz novas possibilidades de as organizações sindicais se colocarem na cena política e aglutinar os interesses de amplos segmentos dos trabalhadores para pressionar o Estado na defesa da melhoria do sistema público de saúde.

  6. Gluten encephalopathy with psychiatric onset: case report

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    Costantini Chiara

    2009-06-01

    Full Text Available Abstract Many cases of coeliac disease, a gastrointestinal autoimmune disorder caused by sensitivity to gluten, can remain in a subclinical stage or undiagnosed. In a significant proportion of cases (10–15% gluten intolerance can be associated with central or peripheral nervous system and psychiatric disorders. A 38-year-old man was admitted as to our department an inpatient for worsening anxiety symptoms and behavioural alterations. After the addition of second generation antipsychotic to the therapeutic regimen, the patient presented neuromotor impairment with high fever, sopor, leukocytosis, raised rhabdomyolysis-related indicators. Neuroleptic malignant syndrome was strongly suspected. After worsening of his neuropsychiatric conditions, with the onset of a frontal cognitive deficit, bradykinesia and difficulty walking, dysphagia, anorexia and hypoferraemic anaemia, SPET revealed a reduction of cerebral perfusion and ENeG results were compatible with a mainly motor polyneuropathy. Extensive laboratory investigations gave positive results for anti-gliadin antibodies, and an appropriate diet led to a progressive remission of the encephalopathy.