Intense soft x-rays from RS Ophiuchi during the 1985 outburst
International Nuclear Information System (INIS)
Mason, K.O.; Cordova, F.A.; Bode, M.F.; Barr, P.
1985-01-01
Intense soft x-ray emission with a characteristic temperature of a few million degrees has been detected from the recurrent nova RS Oph approximately two months after its January 1985 optical outburst. This is the first detection of x-rays from such a system at outburst. The x-radiation is interpreted as emission from circumstellar gas that is shock heated by the passage of the blast wave from the nova explosion. The rapid decline of the x-ray flux between about 60 and 90 days after the outburst probably occurs because the blast wave has reached the edge of the volume filled, between outbursts, by the stellar wind of the red giant component of the binary system. Residual x-ray emission detected from RS Oph 250 days after the outburst is interpreted as coming from the surface of a white dwarf, at a temperature of approx.300,000K, where thermonuclear burning is persisting. 7 refs., 3 figs
International Nuclear Information System (INIS)
Kato, M.
1991-01-01
Sequences of steady mass-loss solutions are constructed for the envelopes on a white dwarf with mass 1.33, 1.35, 1.36, 1.37, and 1.377 solar mass as models of the decay phase of novae. The envelopes are assumed to have a uniform chemical composition with X = 0.73, 0.6, 0.52, 0.44, 0.33, and 0.11 for hydrogen and Z = 0.02 for heavy elements by weight. An excellent agreement with the observed light curves of UV and optical is obtained in the models with a white dwarf mass of 1.36 solar mass with hydrogen content X = 0.52, and 1.37 solar mass with X = 0.6. The distance of RS Oph is obtained to be 1.6 kpc from the comparison between the theoretical and observed light curves. The success of this wind model is a strong indication from the theoretical point of view that RS Oph is a thermonuclear runaway event. 31 refs
RS Ophiuchi: The Gift that Keeps on Giving
Starrfield, S.
2008-12-01
RS Oph experienced its sixth recorded outburst in 2006 and was observed in virtually every wavelength region from hard X-rays to the radio. Each observation, especially those with instruments that have come online since its last outburst in 1985, provided new and exciting information about the explosion. As a result, some of us organized a second workshop on the RS Oph outburst and it was held in June 2007 at Keele University. I gave the lead off talk in which I presented a number of questions to be discussed during the workshop, a brief summary of what had been discovered in previous outbursts concentrating on the ultraviolet studies with IUE, and a few observations of the 2006 outburst concentrating on the results from Swift and HST.
A METHANE IMAGING SURVEY FOR T DWARF CANDIDATES IN ρ OPHIUCHI
International Nuclear Information System (INIS)
Haisch, Karl E.; Barsony, Mary; Tinney, Chris
2010-01-01
We report on the results of the first deep, wide-field, near-infrared methane imaging survey of the ρ Ophiuchi cloud core to search for T dwarfs. Among the 6587 objects detected, 22 were identified as T dwarf candidates. Brown dwarf models indicate that at the age and distance of the ρ Ophiuchi cloud, these T dwarf candidates have masses between 1 and 2 Jupiter masses. If confirmed as genuine T dwarfs, these objects would be the youngest, lowest mass, and lowest gravity free-floating objects ever directly observed. The existence of these candidates suggests that the initial mass function of the ρ Ophiuchi cloud extends well into the regime of planetary mass objects. A large fraction (59% ± 16%) of our T dwarf candidates appear to be surrounded by circumstellar disks, and thus represents the lowest mass objects yet found to harbor circumstellar disks.
International Nuclear Information System (INIS)
Ribeiro, V. A. R. M.; Bode, M. F.; Darnley, M. J.
2009-01-01
We report Hubble Space Telescope (HST) imaging, obtained 155 and 449 days after the 2006 outburst of the recurrent nova RS Ophiuchi, together with ground-based spectroscopic observations, obtained from the Observatorio Astronomico Nacional en San Pedro Martir, Baja California, Mexico and at the Observatorio AstrofIsico Guillermo Haro, at Cananea, Sonora, Mexico. The observations at the first epoch were used as inputs to model the geometry and kinematic structure of the evolving RS Oph nebular remnant. We find that the modeled remnant comprises two distinct co-aligned bipolar components; a low-velocity, high-density innermost (hour glass) region and a more extended, high-velocity (dumbbell) structure. This overall structure is in agreement with that deduced from radio observations and optical interferometry at earlier epochs. We find that the asymmetry observed in the west lobe is an instrumental effect caused by the profile of the HST filter and hence demonstrate that this lobe is approaching the observer. We then conclude that the system has an inclination to the line of sight of 39 +10 -10 . This is in agreement with the inclination of the binary orbit and lends support to the proposal that this morphology is due to the interaction of the outburst ejecta with either an accretion disk around the central white dwarf and/or a pre-existing red giant wind that is significantly denser in the equatorial regions of the binary than at the poles. The second epoch HST observation was also modeled. However, as no spectra were taken at this epoch, it is more difficult to constrain any model. Nevertheless, we demonstrate that between the two HST epochs the outer dumbbell structure seems to have expanded linearly. For the central (hour glass) region, there may be evidence of deceleration, but it is harder to draw firm conclusions in this case.
"Special Case" Stellar Blast Teaching Astronomers New Lessons About Cosmic Explosions
2006-07-01
A powerful thermonuclear explosion on a dense white-dwarf star last February has given astronomers their best look yet at the early stages of such explosions, called novae, and also is giving them tantalizing new clues about the workings of bigger explosions, called supernovae, that are used to measure the Universe. RS Ophiuchi Expansion RS Ophiuchi Expansion CREDIT: Rupen, Mioduszewski & Sokoloski, NRAO/AUI/NSF (Click on image for full-sized image and detailed caption) Using the National Science Foundation's Very Long Baseline Array (VLBA) and other telescopes, "We have seen structure in the blast earlier than in any other stellar explosion," said Tim O'Brien of the University of Manchester's Jodrell Bank Observatory in the U.K. "We see evidence that the explosion may be ejecting material in jets, contrary to theoretical models that assumed a spherical shell of ejected material," O'Brien added. The explosion occurred in a star system called RS Ophiuchi, in the constellation Ophiuchus. RS Ophiuchi consists of a dense white dwarf star with a red giant companion whose prolific stellar wind dumps material onto the surface of the white dwarf. When enough of this material has accumulated, theorists say, a gigantic thermonuclear explosion, similar to a hydrogen bomb but much larger, occurs. Systems such as RS Ophiuchi may eventually produce a vastly more powerful explosion -- a supernova -- when the white dwarf accumulates enough mass to cause it to collapse and explode violently. Because such supernova explosions (called Type 1a supernovae by astronomers) all are triggered as the white dwarf reaches the same mass, they are thought to be identical in their intrinsic brightness. This makes them extremely valuable as "standard candles" for measuring distances in the Universe. "We think the white dwarf in RS Ophiuchi is about as massive as a white dwarf can get, and so is close to the point when it will become a supernova," said Jennifer Sokoloski, of the Harvard
Relative Proper Motions in the Rho Ophiuchi Cluster
2016-01-06
identified as YSOs and may be newly identified cluster members. Key words: ISM: individual objects (Rho Ophiuchi cloud) – stars: formation – stars: pre-main...sequence 1. INTRODUCTION The majority of stars in the Galaxy form in clusters that once the binding mass of the molecular gas is removed, disperse into
Asteroseismic observations and modelling of 70 Ophiuchi AB
Energy Technology Data Exchange (ETDEWEB)
Eggenberger, P; Miglio, A [Institut d' Astrophysique et de Geophysique de l' Universite de Liege, 17 Allee du 6 Aout, B-4000 Liege (Belgium); Carrier, F [Institute of Astronomy, University of Leuven, Celestijnenlaan 200 D, B-3001 Leuven (Belgium); Fernandes, J [Observatorio Astronomico da Universidade de Coimbra e Departamento de Matematica, FCTUC (Portugal); Santos, N C [Centro de AstrofIsica, Universidade do Porto, Rua das Estrelas, P-4150-762 Porto (Portugal)], E-mail: eggenberger@astro.ulg.ac.be
2008-10-15
The analysis of solar-like oscillations for stars belonging to a binary system provides an opportunity to probe the internal stellar structure and to test our knowledge of stellar physics. We present asteroseismic observations of 70 Oph A performed with the HARPS spectrograph together with a comprehensive theoretical calibration of the 70 Ophiuchi system.
Rho Ophiuchi Cloud Core Extinction Map
Gibson, D. J.; Rudolph, A.; Barsony, M.
1997-12-01
We present an extinction map of a one square degree region ( ~ 2.2pc square) of the core of the star-forming region rho Ophiuchi derived by the method of star counts. Photometry from the near-infrared J, H, and K band images of Barsony et al. (1997) provided the stellar catalog for this study. From this map an estimate of the mass of the region is made and compared with previous estimates from other methods. Reference Barsony, M., Kenyon, S.J., Lada, E.A., & Teuben, P.J. 1997, ApJS, 112, 109
The Massive CO White Dwarf in the Symbiotic Recurrent Nova RS Ophiuchi
Mikołajewska, Joanna; Shara, Michael M.
2017-10-01
If accreting white dwarfs (WDs) in binary systems are to produce type Ia supernovae (SNe Ia), they must grow to nearly the Chandrasekhar mass and ignite carbon burning. Proving conclusively that a WD has grown substantially since its birth is a challenging task. Slow accretion of hydrogen inevitably leads to the erosion, rather than the growth of WDs. Rapid hydrogen accretion does lead to growth of a helium layer, due to both decreased degeneracy and the inhibition of mixing of the accreted hydrogen with the underlying WD. However, until recently, simulations of helium-accreting WDs all claimed to show the explosive ejection of a helium envelope once it exceeded ˜ {10}-1 {M}⊙ . Because CO WDs cannot be born with masses in excess of ˜ 1.1 {M}⊙ , any such object in excess of ˜ 1.2 {M}⊙ must have grown substantially. We demonstrate that the WD in the symbiotic nova RS Oph is in the mass range 1.2-1.4 M ⊙. We compare UV spectra of RS Oph with those of novae with ONe WDs and with novae erupting on CO WDs. The RS Oph WD is clearly made of CO, demonstrating that it has grown substantially since birth. It is a prime candidate to eventually produce an SN Ia.
Nova outburst modeling and its application to the recurrent nova phenomenon
International Nuclear Information System (INIS)
Sparks, W.M.; Starrfield, S.; Truran, J.
1985-12-01
The thermonuclear runaway (TNR) theory for the cause of the common novae is reviewed. Numerical simulations of this theory were performed using an implicit hydrodynamic Lagrangian computer code. Relevant physical phenomena are explained with the simpler envelope-in-place calculations. Next the models that include accretion are discussed. The calculations agree very well with observations of common novae. The observational differences between common novae and recurrent novae are examined. We propose input parameters to the TNR model which can give the outburst characteristics of RS Ophiuchi and discuss the implications. This review is concluded with a brief discussion of two current topics in novae research: shear mixing on the white dwarf and Neon novae. 36 refs., 4 figs
International Nuclear Information System (INIS)
Feoktistov, L.P.
1998-01-01
The characteristics of, and energy transfer mechanisms involved in, thermonuclear detonation are discussed. What makes the fundamental difference between thermonuclear and chemical detonation is that the former has a high specific energy release and can therefore be employed for preliminary compressing the thermonuclear mixture ahead of the burning wave. Consequently, with moderate (mega joule) initiation energies, a steady-state detonation laboratory experiment with unlimited energy multiplication becomes a possibility
International Nuclear Information System (INIS)
Feoktistov, L P
1998-01-01
The characteristics of, and energy transfer mechanisms involved in, thermonuclear detonation are discussed. What makes the fundamental difference between thermonuclear and chemical detonation is that the former has a high specific energy release and can therefore be employed for preliminarily compressing the thermonuclear mixture ahead of the burning wave. Consequently, with moderate (megajoule) initiation energies, a steady-state detonation laboratory experiment with unlimited energy multiplication becomes a possibility. (from the history of physics)
Controlled thermonuclear fusion
International Nuclear Information System (INIS)
Rebut, P.H.
1992-01-01
The author gives a chronological account of the research about thermonuclear fusion and presents the principle of JET thermonuclear reactor based upon the magnetic confinement. The problems of heating and confining a thermonuclear plasma may be regarded as solved. They make possible the definition of the size and geometry needed to realize a next-step tokamak (ITER, NET projects)
International Nuclear Information System (INIS)
Frolov, A.M.; Smith, V.H.; Smith, G.T.
2002-01-01
Thermonuclear burn-up and thermonuclear applications are discussed for a number of deuterides and DT hydrides of light elements. These deuterides and corresponding DT hydrides are often used as thermonuclear fuels or components of such fuels. In fact, only for these substances thermonuclear energy gain exceeds (at some densities and temperatures) the bremsstrahlung loss and other high-temperature losses, i.e., thermonuclear burn-up is possible. Herein, thermonuclear burn-up in these deuterides and DT hydrides is considered in detail. In particular, a simple method is proposed to determine the critical values of the burn-up parameter x c for these substances and their mixtures at different temperatures and densities. The results for equimolar DT mixtures coincide quite well with the results of previous calculations. Also, the natural or Z limit is determined for low-temperature thermonuclear burn-up in the deuterides of light elements. (author)
Spectrophotometry of RS Oph during the nebular phase
International Nuclear Information System (INIS)
Bohigas, J.; Echevarria, J.; Diego, F.; Sarmiento, J.A.
1989-01-01
Blue-wavelength spectroscopic observations of RS Oph, 201 day after the 1985 outburst are presented. An analysis of the TiO bands indicates a spectral type M4III for the secondary and a distance of 2 kpc to the system. The system of forbidden lines is excited by a shock wave, whereas Balmer emission is mainly produced by photoionization. The source of photons is probably residual thermonuclear burning occurring at the surface of the white dwarf. (author)
Thermonuclear research development
International Nuclear Information System (INIS)
Velikhov, E.
1977-01-01
Tokamak 10, the world's largest thermonuclear facility was commissioned in 1975. Soviet scientists thus achieved enormous success in producing high-temperature plasma and constructing a thermonuclear fusion source. The problems which remain to be solved include finding a method of regenerating the deuterium-tritium fuel mixture and a method of purifying the reacting high-temperature plasma of heavy elements. The project is designed for a more powerful facility, namely the Tokamak 20 whose toroidal chamber will accommodate a current of 5 to 6 MA and whose plasma volume will be 400 m 3 . (Oy)
Thermonuclear research development
Energy Technology Data Exchange (ETDEWEB)
Velikhov, E
1977-04-01
Tokamak 10, the world's largest thermonuclear facility was commissioned in 1975. Soviet scientists thus achieved enormous success in producing high-temperature plasma and constructing a thermonuclear fusion source. The problems which remain to be solved include finding a method of regenerating the deuterium-tritium fuel mixture and a method of purifying the reacting high-temperature plasma of heavy elements. The project is designed for a more powerful facility, namely the Tokamak 20 whose toroidal chamber will accommodate a current of 5 to 6 MA and whose plasma volume will be 400 m/sup 3/.
Powerful lasers for thermonuclear fusion
International Nuclear Information System (INIS)
Basov, N.; Krokhin, O.; Sklizkov, G.; Fedotov, S.
1977-01-01
The parameters are discussed of the radiation of powerful lasers (internal energy of the plasma determined by the volume, density and temperature of the plasma, duration of the heating pulse, focusing of the laser pulse energy in a small volume of matter, radiation contrast) for attaining an effective thermonuclear fusion at minimum microexplosion energy. A survey is given of the methods of shaping laser pulses with limit parameters, and the principle of the construction of powerful laser systems is described. The general diagram and parameters are given of the Delfin thermonuclear apparatus and a diagram is presented of the focusing system of high luminosity for spherical plasma heating using spherical mirrors. A diagram is presented of the vacuum chamber and of the complex diagnostic apparatus for determining the basic parameters of thermonuclear plasma in the Delfin apparatus. The prospects are indicated of the further development of thermonuclear laser apparatus with neodymium and CO 2 lasers. (B.S.)
Gasior, P.
2014-11-01
Since the process of energy production in the stars has been identified as the thermonuclear fusion, this mechanism has been proclaimed as a future, extremely modern, reliable and safe for sustaining energetic needs of the humankind. However, the idea itself was rather straightforward and the first attempts to harness thermonuclear reactions have been taken yet in 40s of the twentieth century, it quickly appeared that physical and technical problems of domesticating exotic high temperature medium known as plasma are far from being trivial. Though technical developments as lasers, superconductors or advanced semiconductor electronics and computers gave significant contribution for the development of the thermonuclear fusion reactors, for a very long time their efficient performance was out of reach of technology. Years of the scientific progress brought the conclusions that for the development of the thermonuclear power plants an enormous interdisciplinary effort is needed in many fields of science covering not only plasma physics but also material research, superconductors, lasers, advanced diagnostic systems (e.g. spectroscopy, interferometry, scattering techniques, etc.) with huge amounts of data to be processed, cryogenics, measurement-control systems, automatics, robotics, nanotechnology, etc. Due to the sophistication of the problems with plasma control and plasma material interactions only such a combination of the research effort can give a positive output which can assure the energy needs of our civilization. In this paper the problems of thermonuclear technology are briefly outlined and it is shown why this domain can be a broad field for the experts dealing with electronics, optoelectronics, programming and numerical simulations, who at first glance can have nothing common with the plasma or nuclear physics.
International Nuclear Information System (INIS)
Yagi, Yasuomi; Takahashi, Ken; Hashimoto, Hiroshi.
1984-01-01
Purpose: To improve the plasma confining performances by bringing the irregular magnetic fields nearly to zero and decreasing the absolute value of the irregular magnetic fields at every positions. Constitution: The winding direction of a plurality of coil elements, for instance, double pan cake coils of toroidal coils in a torus type or mirror type thermonuclear device are reversed to each other in their laminating direction, whereby the irregular magnetic fields due to the coil-stepped portions in each toroidal coils are brought nearly to zero. This enables to bring the average irregular magnetic fields as a whole in the thermonuclear device nearly to zero, as well as, decrease the absolute value of the irregular magnetic fields in each positions. Thus, the plasma confining performances can be improved. (Moriyama, K.)
Control method for thermonuclear plasma
International Nuclear Information System (INIS)
Azuma, Kingo; Oda, Yasushi.
1997-01-01
CT (Compact Troid) is a doughnut-like shaped plasmas having a toroidal current and a poloidal current at the inside and forming a poloidal magnetic fluxes and toroidal magnetic flux. The structure of the CT is collapsed at a time of stationary state, accordingly, when it is injected to thermonuclear plasmas, particles can be supplied locally, and the state of the plasmas to be supplied can be changed by changing the direction of the injection. If a CT which is reverse to the poloidal magnetic fields is injected, plasmas with excessive ions can be supplied locally thereby enabling to form magnetic field in the thermonuclear plasmas. If the magnetic fields are formed in the vicinity of the surface of the thermonuclear plasmas, fast ions which have come over the magnetic field structure can be returned to the central portion of the plasmas. Then, confining performance of thermonuclear plasmas can be greatly improved, the efficiency for fuel supply can be increased, and energy required for ignition can be suppressed. (N.H.)
Thermonuclear reaction generation method and device
International Nuclear Information System (INIS)
Imazaki, Kazuo
1998-01-01
The present invention provides a method of and a device for causing thermonuclear reaction capable of obtaining extremely high profits (about 1000 times), capable of forming a target which is strong against instability upon implosion as a problem of an inertia process and capable of realizing utilization of nuclear fusion. Namely, elementary particles such as pion, muon and K particles are deposited a portion or some portion of thermonuclear fuel materials by using high energy ions and highly brilliant γ rays generated from a high energy accelerator. The thermonuclear fuel materials are compressed to high density. The nuclear fusion reaction is promoted to ignite and burn thermonuclear fuels. A portion of nuclear fuels is ignited selectively by the means. High profits can be obtained. Since there is no need to attain implosion rate required for self ignition of nuclear fuels, a target of low aspect ratio can be used. (I.S.)
Research into thermonuclear fusion
International Nuclear Information System (INIS)
Schumacher, U.
1989-01-01
The experimental and theoretical studies carried out in close international cooperation in the field of thermonuclear fusion by magnetic plasma confinement have achieved such progress towards higher plasma temperatures and densities, longer confinement times and, thus, increased fusion product, that emphasis now begins to be shifted from problems of physics to those of technology as a next major step is being prepared towards a large international project (ITER) to achieve thermonuclear burning. The generation and maintenance of a burning fusion plasma in an experimental physics phase will be followed by a phase of technical materials studies at high fluxes of fusion neutrons. These goals have been pursued since 1983 by an international study group at Garching working on the design of a Next European Torus (NET). Since May 1988, an international study group comprising ten experts each from the USSR, USA, Japan, and the European Community has begun to work on a design draft of ITER (International Thermonuclear Experimental Reactor) in Garching under the auspices of IAEA. (orig.) [de
Controlled thermonuclear fusion
International Nuclear Information System (INIS)
Sakanaka, P.H.
1984-01-01
A simplified review on the status of the controlled thermonuclear fusion research aiming to present the motivation, objective, necessary conditions and adopted methods to reach the objective. (M.C.K.) [pt
Ecological problems of thermonuclear energetics. Review
Energy Technology Data Exchange (ETDEWEB)
Sivintsev, Yu V
1980-01-01
A review of preliminary quantitative estimates of radiation hazard of thermonuclear reactors is presented. Main attention is given to three aspects: nonradiation effect on environment, radionuclide blow-ups at normal operation and emergency situations with their consequences. The given data testify to great radiological advantages of thermonuclear energetics as compared with the modern nuclear energetics with thermal and prospective fast reactors.
Thermonuclear power plants and the environment
International Nuclear Information System (INIS)
Becka, J.
1978-01-01
Environmental safety and protection from the effects of the thermonuclear power plants are discussed. Factors are assessed which should be considered in the choice of fuel and breeding material of a thermonuclear reactor, the problems of structural material activation and the overall reactor concepts. Main specifications are given of the US thermonuclear power plant projects with D-T reaction based reactors. The overall amounts of tritium in the reactor cycles are shown. The potential biological risk is evaluated for the different materials considered for the UWMAK-1 project. Discussed are possible pathways of activity release in normal plant operation, non-radioactive aspects, such as waste heat, the magnetic field effect on personnel and population, etc., as well as possible environmental impacts in case of accidents. (B.S.)
International Nuclear Information System (INIS)
Weisse, J.
2000-01-01
This document takes stock of the two ways of thermonuclear fusion research explored today: magnetic confinement fusion and inertial confinement fusion. The basic physical principles are recalled first: fundamental nuclear reactions, high temperatures, elementary properties of plasmas, ignition criterion, magnetic confinement (charged particle in a uniform magnetic field, confinement and Tokamak principle, heating of magnetized plasmas (ohmic, neutral particles, high frequency waves, other heating means), results obtained so far (scale laws and extrapolation of performances, tritium experiments, ITER project), inertial fusion (hot spot ignition, instabilities, results (Centurion-Halite program, laser experiments). The second part presents the fusion reactor and its associated technologies: principle (tritium production, heat source, neutron protection, tritium generation, materials), magnetic fusion (superconducting magnets, divertor (role, principle, realization), inertial fusion (energy vector, laser adaptation, particle beams, reaction chamber, stresses, chamber concepts (dry and wet walls, liquid walls), targets (fabrication, injection and pointing)). The third chapter concerns the socio-economic aspects of thermonuclear fusion: safety (normal operation and accidents, wastes), costs (costs structure and elementary comparison, ecological impact and external costs). (J.S.)
Important problems of future thermonuclear reactors*
Directory of Open Access Journals (Sweden)
Sadowski Marek J.
2015-06-01
Full Text Available This paper concerns important and difficult problems connected with a design and construction of thermonuclear reactors, which have to use nuclear fusion reactions of heavy isotopes of hydrogen, i.e., deuterium (D and tritium (T. There are described conditions in which such reactions can occur, and different methods of a high-temperature plasma generation, i.e., high-current electrical discharges, intense microwave pulses, and injection of energetic neutral atoms (NBI. There are also presented experimental facilities which can contain hot plasma for an appropriate period, and particularly so-called tokamaks. The second part presents the technical problems which must be solved in order to build a thermonuclear reactor, that might be used for energetic purposes. There are considered problems connected with a choice of constructional materials for a vacuum chamber, its internal parts, external windings generating a magnetic field, and necessary shields. The next part considers the handling of radioactive tritium; the using of alpha particles (4He for additional heating of plasma; recuperation of hydrogen isotopes absorbed in the tokamak internal parts, and a removal of a helium excess. There is presented a scheme of a future thermonuclear power plant and critical comments on a road map which should enable the construction of an industrial thermonuclear reactor (DEMO.
Structure of thermonuclear reactor wall
International Nuclear Information System (INIS)
Yamazaki, Seiichiro.
1991-01-01
In a thermonuclear reactor wall, there has been a worry that the brazing material is melted by high temperature heat and particle load, to peel off the joined portion and the protecting material is destroyed by temperature elevation, to expose the heat sink material. Then, in the reactor core structures of a thermonuclear reactor, such as a divertor plate comprising a protecting material made of carbon material and the heat sink material joined by brazing, a plate material made of a so-called refractory metal having a high atomic number such as tungsten, molybdenum or the alloy thereof is embedded or attached to an accurate position of the protecting material. This can prevent the brazing portion from destruction by escaping electrons generated upon occurrence of abnormality in the thermonuclear reactor, and peeling or destroy of the protecting material and the heat sink material. Sufficient characteristics of plasmas can always be maintained by disposing a material having a small atomic number, for example, carbon material, to the position facing to the plasmas. (N.H.)
International Nuclear Information System (INIS)
Sparks, W.M.; Kutter, G.S.; Starrfield, S.; Truran, J.W.
1989-01-01
The nova outburst requires an energy source that is energetic enough to eject material and is able to recur. The Thermonuclear Runaway (TNR) model, coupled with the binary nature of nova systems satisfies these conditions. The white dwarf/red dwarf binary nature of novae was first recognized as a necessary conditions by Kraft. The small separation characteristic of novae systems allows the cool, red secondary to overflow is Roche lobe. In the absence of strong, funneling magnetic fields, the angular momentum of this material prevents it from falling directly onto the primary, and it first forms a disk around the white dwarf. This material is eventually accreted from the disk onto the white dwarf. As the thickness of this hydrogen-rich layer increases, the degenerate matter at the base reaches a temperature that is high enough to initiate thermonuclear fusion of hydrogen. Thermonuclear energy release increases the temperature which in turn increases the energy generation rate. Because the material is degenerate, the pressure does not increase with temperature, which normally allows a star to adjust itself to a steady nuclear burning rate. Thus the temperature and nuclear energy generation increase and a TNR results. When the temperature reaches the Fermi temperature, degeneracy is lifted and the rapid pressure increase causes material expansion. The hydrogen-rich material either is ejected or consumed by nuclear burning, and the white dwarf returns to its pre-outburst state. The external source of hydrogen fuel from the secondary allows the while process to repeat. 43 refs., 8 figs
Merging White Dwarfs and Thermonuclear Supernovae
van Kerkwijk, Marten H.
2012-01-01
Thermonuclear supernovae result when interaction with a companion reignites nuclear fusion in a carbon-oxygen white dwarf, causing a thermonuclear runaway, a catastrophic gain in pressure, and the disintegration of the whole white dwarf. It is usually thought that fusion is reignited in near-pycnonuclear conditions when the white dwarf approaches the Chandrasekhar mass. I briefly describe two long-standing problems faced by this scenario, and our suggestion that these supernovae instead resul...
Advance in physics of laser thermonuclear fusion
International Nuclear Information System (INIS)
Afanasev, J.; Basov, N.; Gamalij, J.; Krokhin, O.; Rozanov, V.
1977-01-01
A survey is given of current advance in the physics of laser thermonuclear fusion (LTF). The LTF physical model is discussed with regard to the optimal laser-target systems not only for attaining the physical limit but also for future thermonuclear reactors. The basic physical principles of LTF are formulated which make use of the fact that in focusing laser radiation on the surface of a substance a high density may be attained of the energy flux (10 5 to 10 6 J) and thereby also a high velocity of energy release in the substance. A detailed description is given of the processes which take place in laser irradiation of a spherical target. The problem is discussed of hydrodynamic stability in the compression of matter in laser thermonuclear targets, the concept is explained of the physical threshold of a thermonuclear reaction in laser excitation as are the conditions for attaining this threshold. The quantitative criterion is examined of the attainment of the physical threshold of LTF for pulsed systems. (B.S.)
[International Thermonuclear Experimental Reactor support
International Nuclear Information System (INIS)
Dean, S.O.
1990-01-01
This report summarizes the activities under LLNL Purchase Order B089367, the purpose of which is to ''support the University/Lawrence Livermore National Laboratory Magnetic Fusion Program by evaluating the status of research relative to other national and international programs and assist in long-range plans and development strategies for magnetic fusion in general and for ITER in particular.'' Two specific subtasks are included: ''to review the LLNL Magnet Technology Development Program in the context of the International Thermonuclear Experimental Reactor Design Study'' and to ''assist LLNL to organize and prepare materials for an International Thermonuclear Experimental Reactor Design Study information meeting.''
Controlled thermonuclear fusion
International Nuclear Information System (INIS)
Trocheris, M.
1975-01-01
An outline is given of the present position of research into controlled fusion. After a brief reminder of the nuclear reactions of fusion and the principle of their use as a source of energy, the results obtained by the method of magnetic confinement are summarized. Among the many solutions that have been imagined and tried out to achieve a magnetic containing vessel capable of holding the thermonuclear plasma, the devices of the Tokamak type have a good lead and that is why they are described in greater detail. An idea is then given of the problems that arise when one intends conceiving the thermonuclear reactor based on the principle of the Tokamaks. The last section deals with fusion by lasers which is a new and most attractive alternative, at least from the viewpoint of basis physics. The report concludes with an indication of the stages to be passed through to reach production of energy on an industrial scale [fr
Thermonuclear model for high energy transients
International Nuclear Information System (INIS)
Woosley, S.E.
1982-01-01
The thermonuclear model for x- and γ-ray bursts is discussed. Different regimes of nuclear burning are reviewed, each appropriate to a given range of (steady state) accretion rate. Accretion rates in the range 10 -14 to 10 -8 Msub solar y -1 all appear capable of producing x-ray transients of various durations and intervals. Modifications introduced by radiatively driven mass loss, the thermal inertia of the envelope, different burning mechanisms, and two-dimensional considerations are discussed as are difficulties encountered when the thermonuclear model is confronted with observations of rapidly recurrent bursts (less than or equal to 10 min), and super-Eddington luminosities and temperatures. Results from a numerical simulation of a combined hydrogen-helium runaway initiated at pycnonuclear density are presented for the first time. The thermonuclear model for γ-ray bursts is also reviewed and updated, particularly with regard to the breakdown of the steady state hypothesis employed in previous work. Solely on the basis of nuclear instability, γ-ray bursts of various types appear possible for a very broad variety of accretion rates (approx. 10 -17 to approx. 10 -11 Msub solar y -1 ) although other considerations may restrict this range. The thermonuclear model appears capable of yielding a great diversity of high energy transient phenomena for various accretion rates, magnetic field configurations, and neutron star envelope histories
An electromagnetic spherical phased array thermonuclear fusion reactor
International Nuclear Information System (INIS)
Okress, E.C.
1983-01-01
Discussed are salient physics aspects of a microwave singly reentrant spherical periodic phased array of uniformally distributed identical coaxial radiation elements in an essentially simulated infinite array environment. The array is capable of maintaining coherence or phase control (to the limit of the order of 300 GHz) of its spherically converging electromagnetic transverse magnetic mode radiation field, for confinement (and heating) of thermonuclear plasma in steady-state or inertial thermonuclear fusion. The array also incorporates capability for coaxial directional coupler extraction of fusionpower. The radiation elements of the array are shielded against DT Thermonuclear plasma emissions (i.e., neutrons and bremsstrahlung) by either sufficiently (available) low less tangent and cooled, spherically concentric shield (e.g., Titanium oxide); or alternately by identical material dome windows mounted on each radiation element's aperture of the array. The pump microwave power required for thermonuclear fusion feasibility comprises an array of phase-locked available klystron amplifiers (comparable gyratron amplifiers remain to be developed)
Controlled thermonuclear fusion
Bobin, Jean Louis
2014-01-01
The book is a presentation of the basic principles and main achievements in the field of nuclear fusion. It encompasses both magnetic and inertial confinements plus a few exotic mechanisms for nuclear fusion. The state-of-the-art regarding thermonuclear reactions, hot plasmas, tokamaks, laser-driven compression and future reactors is given.
Thermonuclear plasma physic: inertial confinement fusion
International Nuclear Information System (INIS)
Bayer, Ch.; Juraszek, D.
2001-01-01
Inertial Confinement Fusion (ICF) is an approach to thermonuclear fusion in which the fuel contained in a spherical capsule is strongly compressed and heated to achieve ignition and burn. The released thermonuclear energy can be much higher than the driver energy, making energetic applications attractive. Many complex physical phenomena are involved by the compression process, but it is possible to use simple analytical models to analyze the main critical points. We first determine the conditions to obtain fuel ignition. High thermonuclear gains are achieved if only a small fraction of the fuel called hot spot is used to trigger burn in the main fuel compressed on a low isentrope. A simple hot spot model will be described. The high pressure needed to drive the capsule compression are obtained by the ablation process. A simple Rocket model describe the main features of the implosion phase. Several parameters have to be controlled during the compression: irradiation symmetry, hydrodynamical stability and when the driver is a laser, the problems arising from interaction of the EM wave with the plasma. Two different schemes are examined: Indirect Drive which uses X-ray generated in a cavity to drive the implosion and the Fast Ignitor concept using a ultra intense laser beam to create the hot spot. At the end we present the Laser Megajoule (LMJ) project. LMJ is scaled to a thermonuclear gain of the order of ten. (authors)
Blankets for thermonuclear device
International Nuclear Information System (INIS)
Maki, Koichi; Fukumoto, Hideshi.
1986-01-01
Purpose: To produce tritium more than consumed, through thermonuclear reaction. Constitution: The energy spectrum of neutron generated by neutron multiplying reaction in a neutron multiplying blanket and moderated neutrons has a large ratio in a low energy section. In the low-energy absorption region of stainless steel which is a material of cooling pipes constituting a neutron multiplying blanket cooling channel, the neutrons are absorbed, lessening the neutron multiplying effect. To prevent this, the neutron multiplying blanket cooling channel is covered with tritium breeding blankets, thereby enabling the production of a substantially great amount of tritium more than the amount of tritium to be consumed by the thermonuclear reaction by preventing neutron absorption by the component materials of the cooling channel, improving the tritium breeding ratio by 20 to 25 %, and increasing the efficiency of use of neutrons for tritium generation. (Horiuchi, T.)
Thermonuclear energy and the power industry in the future
International Nuclear Information System (INIS)
Velikhov, E.P.
1986-01-01
The leader of the USSR thermonuclear program, the vicepresident of the Academy of Science, comrade Velikhov tells about the modern state and perspective of thermonuclear investigations, as well as about the problems on the international cooperation in this field
Plasma and controlled thermonuclear reaction
Energy Technology Data Exchange (ETDEWEB)
Kapitsa, P L [AN SSSR, Moscow. Inst. Fizicheskikh Problem
1980-06-01
Two contemporary trends of research are characterized aiming at the thermonuclear reactor, viz., tokamak type equipment and pulsed heating of a deuterium-tritium mixture using focused laser light. There is a third trend based on the use of high-power continuous wave (CW) microwave generators which allow producing a rope discharge. The design is described of an anticipated CW thermonuclear reactor. Using current experimental facilities, a continuous high-frequency discharge can be obtained at a pressure of 25 atm and electron temperature of 50 million K. The major problem involved in the design of a CW reactor is the heating of ions to the same temperature as the electron temperature and the reduction in ion gas thermal conductivity.
Rates of Thermonuclear Reactions in Dense Plasmas
International Nuclear Information System (INIS)
Tsytovich, V.N.; Bornatici, M.
2000-01-01
The problem of plasma screening of thermonuclear reactions has attracted considerable scientific interest ever since Salpeter's seminal paper, but it is still faced with controversial statements and without any definite conclusion. It is of relevant importance to thermonuclear reactions in dense astrophysical plasmas, for which charge screening can substantially affect the reaction rates. Whereas Salpeter and a number of subsequent investigations have dealt with static screening, Carraro, Schafer, and Koonin have drawn attention to the fact that plasma screening of thermonuclear reactions is an essentially dynamic effect. In addressing the issue of collective plasma effects on the thermonuclear reaction rates, the first critical overview of most of the work carried out so far is presented and the validity of the test particle approach is assessed. In contrast to previous investigations, we base our description on the kinetic equation for nonequilibrium plasmas, which accounts for the effects on the rates of thermonuclear reactions of both plasma fluctuations and screening and allows one to analyze explicitly the effects of the fluctuations on the reaction rates. Such a kinetic formulation is more general than both Salpeter's approach and the recently developed statistical approaches and makes it possible to obtain a more comprehensive understanding of the problem. A noticeable result of the fluctuation approach is that the static screening, which affects both the interaction and the self-energy of the reacting nuclei, does not affect the reaction rates, in contrast with the results obtained so far. Instead, a reduction of the thermonuclear reaction rates is obtained as a result of the effect of plasma fluctuations related to the free self-energy of the reacting nuclei. A simple physical explanation of the slowing down of the reaction rates is given, and the relation to the dynamically screened test particle approach is discussed. Corrections to the reaction rates
Inertia-confining thermonuclear molten salt reactors
International Nuclear Information System (INIS)
Furukawa, Kazuo; Yamanaka, Chiyoe; Nakai, Sadao; Imon, Shunji; Nakajima, Hidenori; Nakamura, Norio; Kato, Yoshio.
1984-01-01
Purpose: To increase the heat generating efficiency while improving the reactor safety and thereby maintaining the energy balance throughout the reactor. Constitution: In an inertia-confining type D-T thermonuclear reactor, the blanket is made of lithium-containing fluoride molten salts (LiF.BeF 2 , LiF.NaF.KF, LiF.KF, etc) which are cascaded downwardly in a large thickness (50 - 100 cm) along the inner wall of the thermonuclear reaction vessel, and neutrons generated by explosive compression are absorbed to lithium in the molten salts to produce tritium, Heat transportation is carried out by the molten salts. (Ikeda, J.)
Capacitor requirements for controlled thermonuclear experiments and reactors
International Nuclear Information System (INIS)
Boicourt, G.P.; Hoffman, P.S.
1975-01-01
Future controlled thermonuclear experiments as well as controlled thermonuclear reactors will require substantial numbers of capacitors. The demands on these units are likely to be quite severe and quite different from the normal demands placed on either present energy storage capacitors or present power factor correction capacitors. It is unlikely that these two types will suffice for all necessary Controlled Thermonuclear Research (CTR) applications. The types of capacitors required for the various CTR operating conditions are enumerated. Factors that influence the life, cost and operating abilities of these types of capacitors are discussed. The problems of capacitors in a radiation environment are considered. Areas are defined where future research is needed. Some directions that this research should take are suggested. (U.S.)
Capacitor requirements for controlled thermonuclear experiments and reactors
International Nuclear Information System (INIS)
Boicourt, G.P.; Hoffman, P.S.
1975-01-01
Future controlled thermonuclear experiments as well as controlled thermonuclear reactors will require substantial numbers of capacitors. The demands on these units are likely to be quite severe and quite different from the normal demands placed on either present energy storage capacitors or present power factor correction capacitors. It is unlikely that these two types will suffice for all necessary Controlled Thermonuclear Research (CTR) applications. The types of capacitors required for the various CTR operating conditions are enumerated. Factors that influence the life, cost and operating abilities of these types of capacitors are discussed. The problems of capacitors in a radiation environment are considered. Areas are defined where future research is needed. Some directions that this research should take are suggested
Thermonuclear investigation development
International Nuclear Information System (INIS)
Pistunovich, V.I.; Solov'ev, N.S.
1975-01-01
The patent situation, based mainly on a study of the situations of Great Britain, USA, France, Federal Republic of Germany and Japan from 1958 to 1974 is reviewed. Applicants have obtained around 300 patents on equipment for control of thermonuclear reactions. In the second half some decrease in the introduction of patents on high-temperature-plasma studies is noted. Multipole magnet systems for holding plasma and toroidal equipment of the takamak type have been developed recently. In the 70s, patents were published on the use of high-energy electrons for stabilization and heating of plasma in toroidal stationary systems. Starting with the mid 60s, considerable attention has been given to heating of plasma with laser radiation and to conversion of thermonuclear energy to electrical. There are 20 domestic patents on laser heating of plasma, and 75 and 45 domestic patents, respectively, on open and composite traps and 120 and 40 such patents abroad. While in the 60s equipment of different types was patented in many directions, part of which has not found further use, today work abroad is being patented basically on laser heating of plasma, toroidal magnetic systems, ion beam interference, and plasma bunching
International Nuclear Information System (INIS)
Madarame, Haruki; Nakamura, Norio; Oomura, Hiroshi.
1983-01-01
Purpose: To enable effective recovery of the thermonuclear reaction energy and effective protection of a cylinder metal against thermal destruction by forming a uniform and stable liquid metal wall to the inside of a cylindrical member. Constitution: Cylindrical body having a lateral axis is rotatably supported so that a liquid metal wall for use in the wet wall type thermonuclear device is formed centrifugally. A liquid metal injection port for injecting the liquid metal to the cylindrical member is disposed to the lateral axis and a liquid metal exit for flowing out the injected liquid metal is disposed to the body of the cylindrical member, so as to form a moving liquid metal layer flowing from the injection port through the inner circumferential surface of the cylindrical member to the liquid metal exit port. Then, the liquid metal is centrifugally forced to the inner surface of the cylindrical body to form a uniform and stable liquid metal wall at the inner surface of the cylindrical body, whereby the reaction energy can effectively be recovered and the cylinder metal can effectively be protected against thermal destruction. (Yoshihara, H.)
Localized thermonuclear runaways and volcanoes on degenerate dwarf stars
Energy Technology Data Exchange (ETDEWEB)
Shara, M.M.
1982-10-15
Practically all studies to date of thermonuclear runaways on degenerate dwarf stars in binary systems have considered only spherically symmetric eruptions. We emphasize that even slightly non-spherically symmetric accretion leads to transverse temperature gradients in the dwarfs' accreted envelopes. Over a rather broad range of parameter space, thermalization time scales in accreted envelopes are much longer than thermonuclear runaway time scales. Thus localized thermonuclear runaways (i.e., runaways much smaller than the host degenerate star) rather than spherically symmetric global eruptions are likely to occur on many degenerate dwarfs. Localized runaways are more likely to occur on more massive and/or hotter dwarfs.
The international thermonuclear reactor project
International Nuclear Information System (INIS)
James, T.R.
1993-01-01
The International Thermonuclear Experimental Reactor Project is a 6-year collaborative effort involving the U.S., Europe, Japan, and the Russian Federation to produce a detailed engineering design for the next-step fusion device
Merging white dwarfs and thermonuclear supernovae.
van Kerkwijk, M H
2013-06-13
Thermonuclear supernovae result when interaction with a companion reignites nuclear fusion in a carbon-oxygen white dwarf, causing a thermonuclear runaway, a catastrophic gain in pressure and the disintegration of the whole white dwarf. It is usually thought that fusion is reignited in near-pycnonuclear conditions when the white dwarf approaches the Chandrasekhar mass. I briefly describe two long-standing problems faced by this scenario, and the suggestion that these supernovae instead result from mergers of carbon-oxygen white dwarfs, including those that produce sub-Chandrasekhar-mass remnants. I then turn to possible observational tests, in particular, those that test the absence or presence of electron captures during the burning.
International Nuclear Information System (INIS)
Clayton, D.D.; Woosley, S.E.
1974-01-01
We discuss the types of thermonuclear reactions that are of importance to stellar evolution and nucleosynthesis, with particular attention to the explosive ejection of shells of He, C, O, and Si. We present tables of the reactions important in the various burning phases, including the reason for their importance and an estimate of the value of a carefully measured rate. This format is chosen for dual purpose: (1) to clarify the nuclear needs by evaluating the importance of specific reactions within the astronomical settings and (2) by assigning a value scale for cross-section measurements
International Nuclear Information System (INIS)
Ngoc Phan-Bao; Lee, Chin-Fei; Ho, Paul T. P.; Tang, Ya-Wen
2011-01-01
We report here our search for molecular outflows from young very low mass stars and brown dwarfs in Taurus and ρ Ophiuchi. Using the Submillimeter Array and the Combined Array for Research in Millimeter-wave Astronomy, we have observed four targets at 1.3 mm wavelength (230 GHz) to search for CO J = 2 → 1 outflows. A young very low mass star MHO 5 (in Taurus) with an estimated mass of 90 M J , which is just above the hydrogen-burning limit, shows two gas lobes that are likely outflows. While the CO map of MHO 5 does not show a clear structure of outflow, possibly due to environment gas, its position-velocity diagram indicates two distinct blue- and redshifted components. We therefore conclude that they are components of a bipolar molecular outflow from MHO 5. We estimate an outflow mass of 7.0 x 10 -5 M sun and a mass-loss rate of 9.0 x 10 -10 M sun . These values are over two orders of magnitude smaller than the typical ones for T Tauri stars and somewhat weaker than those we have observed in the young brown dwarf ISO-Oph 102 of 60 M J in ρ Ophiuchi. This makes MHO 5 the first young very low mass star showing a bipolar molecular outflow in Taurus. The detection boosts the scenario that very low mass objects form like low-mass stars but in a version scaled down by a factor of over 100.
Towards upper power levels: thermonuclear fusion
International Nuclear Information System (INIS)
Vedel, Jean
1983-01-01
This paper is a brief introduction to the use of power lasers to achieve controlled thermonuclear fusion. After shortly describing thermonuclear fusion and the conditions of temperature, density and duration required it is showed how the laser enables such conditions to be created. The neodymium-doped glass laser NOVA that is being installed at the Livermore laboratory in the USA is described; at the time of its completion in 1984, this laser will be the most powerful in the world. In comparison, the OCTAL laser in operation at the Limeil establishment ''Centre d'Etudes'' of ''Commissariat Francais a l'Energie Atomique'' (the French atomic energy authority) is more modest; it is presented here [fr
SMA and CARMA observations of young brown dwarfs in ρ Ophiuchi and Taurus
Directory of Open Access Journals (Sweden)
Lee C.-F.
2011-07-01
Full Text Available Molecular outflows provide vital information about the earliest stages in the birth of stars, studying the molecular outflow properties is therefore crucial for understanding how stars form. Brown dwarfs with masses between that of stars and planets are not massive enough to maintain stable hydrogen-burning fusion reactions during most of their lifetime. Their origins are subject to much debate in recent literature because their masses are far below the typical mass where core collapse is expected to occur. Based on Submillimeter Array (SMA and Combined Array for Research in Millimeter-wave Astronomy (CARMA observations, we present the first detections of bipolar molecular outflows from young brown dwarfs in ρ Ophiuchi and Taurus. Our results demonstrate that the bipolar molecular outflow operates down to brown dwarf masses, occurring in brown dwarfs as a scaled-down version of the universal process seen in young low-mass stars. This demonstrates that brown dwarfs and low-mass stars likely share the same formation mechanism.
Temperature measurements in thermonuclear plasmas
International Nuclear Information System (INIS)
Breton, D.
1958-01-01
The temperatures needed to produce thermonuclear reactions are of the order of several million degrees Kelvin. Devising methods for measuring such temperatures has been the subject of research in many countries. In order to present the problem clearly and to demonstrate its importance, the author reviews the various conditions which must be fulfilled in order that reactions may be qualified as thermonuclear. The relationship between the temperature and the cross-section of the reactions is studied, and it is shown that the notion of temperature in the plasmas is complex, which leads to a consideration of the temperature of the ions and that of the electrons. None of the methods for the temperature measurements is completely satisfactory because of the hypotheses which must be made, and which are seldom fulfilled during high-intensity discharges in the plasmas. In practice it is necessary to use several methods simultaneously. (author) [fr
Thermonuclear reaction rates. III
International Nuclear Information System (INIS)
Harris, M.J.; Fowler, W.A.; Caughlan, G.R.; Zimmerman, B.A.
1983-01-01
Stellar thermonuclear reaction rates are revised and updated, adding a number of new important reaction rates. Several reactions with large negative Q-values are included, and examples of them are discussed. The importance of the decay rates for Mg-26(p,n) exp 26 Al and Al-26(n,p) exp 26 Mg for stellar studies is emphasized. 19 references
Resonant thermonuclear reaction rate
International Nuclear Information System (INIS)
Haubold, H.J.; Mathai, A.M.
1986-01-01
Basic physical principles for the resonant and nonresonant thermonuclear reaction rates are applied to find their standard representations for nuclear astrophysics. Closed-form representations for the resonant reaction rate are derived in terms of Meijer's G-function. Analytic representations of the resonant and nonresonant nuclear reaction rates are compared and the appearance of Meijer's G-function is discussed in physical terms
Thermonuclear reaction listing
International Nuclear Information System (INIS)
Fukai, Yuzo
1993-01-01
The following 10 elements, including T, are well known as nuclear fusion fuels: p, D, T, 3 He, 4 He, 6 Li, 7 Li, 9 Be, 10 B, 11 B, ( 12 C, 13 C), where 12 C and 13 C are considered only in the calculation of Q value. Accordingly the number of the thermonuclear reactions is 55, and 78, if including carbon elements. The reactions have some branches. For the branches having two and three reaction products, the reaction products, Q value and threshold energy are calculated by using a computer. We have investigated those of the branches having more than three products from the papers of Ajzenberg-Selove and so on. And also, by the same papers, we check whether the above mentioned branch has been observed or not. The results are as follows: (I) the number of reactions which have Q 0 branches only with γ ray production, and Q 0 and neutron production is 36(17), and (IV) that of reactions whose branch with Q > 0 does not produce neutrons is 9(3). The value in the parentheses shows the number of the case of the carbon elements. For 55 thermonuclear reactions induced by lighter nuclides than 11 B, the reaction products, the values of Q and threshold energy, and the papers with reaction cross section data are presented in the tables. (author)
Magnetohydrodynamics and the thermonuclear problem
Energy Technology Data Exchange (ETDEWEB)
Alfven, H [Department of Electronics, Royal Institute of Technology, Stockholm (Sweden)
1958-07-01
The importance of magnetohydrodynamics and plasma physics for the solution of thermonuclear problem is presented in the paper. Methods for capture of a plasma by a magnetic field are discussed. From the study it is concluded that in principle it is possible to shoot heated plasma into a magnetic field and capture it there. A possible method of capturing plasma which is shot into a magnetic field is illustrated. Magnetohydrodynamic research performed during the last decade in Stockholm is presented. Following a long series of investigations of relatively cool plasmas, it has been started a series of experimental investigations on hot plasmas, concentrating on the fundamental properties of the plasma. New ways of the approach to the thermonuclear problem are analysed. Experiments have been with discharges of a few hundred kiloamps to produce fast-moving magnetized plasmas, in order to investigate whether they could be captured by magnetic fields in the discussed way.
Thermonuclear controlled fusion: international cooperation
International Nuclear Information System (INIS)
Conscience, J.-F.
2001-01-01
This report summarizes the current worldwide status of research in the field of thermonuclear controlled fusion as well as the international research programme planed for the next decades. The two main projects will be the ITER facility (International Thermonuclear Experimental Reactor) that should produce 10 times more energy than the energy injected, and the IFMIF (International Fusion Materials Irradiation Facility) designed to study the reactions of materials under intense neutron fluxes. The future of the pioneering JET facility (Joint European Torus) is also discussed. The engagement of the various countries (USA, Japan, Germany, Russian Federation and Canada) and international organisations (EURATOM and IEA) in terms of investment and research is described. Switzerland is involved in this program through an agreement with EURATOM and is mainly dedicated to experimental studies with the TCV machine in Lausanne and numerical studies of plasma configurations. It will participate to the development of the microwave plasma heating system for the ITER machine
Radio-emission of pre-main sequence stars of the Rho Ophiuchi cloud: observations and interpretation
International Nuclear Information System (INIS)
Andre, P.
1987-11-01
Observations of the radio continuum emission of a young star population have been made at VLA on the whole molecular cloud Rho Ophiuchi, one of the closest site of star formation. A dozen of stellar sources have been detected. Radio emission of some identified objects seems to have a magnetic nature and be produced by gyrosynchrotron mechanism. In particular, one of the sources shows a radio radiation circularly polarized; two other stars have a radiation strongly variable probably due to magnetic eruptions more important than those detected in X radiation. More generally, radio observations select probably a specific population of young stars characterized by magnetic field presence extended on several stellar radii and by absence of dense circumstellar environment. Spatial distribution of these objects suggest, they are younger than most of the pre-main sequence stars [fr
International Nuclear Information System (INIS)
Inoue, Toyokazu; Murata, Toru.
1983-01-01
Purpose: To shield superconducting coils for use in the generation of magnetic field against neutron irradiation thereby preventing tritium contamination. Constitution: The thermonuclear device comprises, in its inside, a vacuum container for containing plasmas, superconducting coils disposed to the outside of the vacuum container and neutron absorbers disposed between the super-conducting coils and the vacuum container. since neutrons issued from the plasma are absorbed by neutron absorbers and not irradiated to the superconducting coils, generation of tritium due to the reaction between 3 He in the liquid helium as the coolants for the super-conducting coils and the neutrons is prevented. (Aizawa, K.)
IRAS observations of dust heating and energy balance in the Rho Ophiuchi dark cloud
Greene, Thomas P.; Young, Erick T.
1989-01-01
The equilibrium process dust emission in the Rho Ophiuchi dark cloud is studied. The luminosity of the cloud is found to closely match the luminosity of the clouds's known embedded and external radiation sources. There is no evidence for a large population of undetected low-luminosity sources within the cloud and unknown external heating is also only a minor source of energy. Most of the cloud's luminosity is emitted in the mid-to-far-IR. Dust temperature maps indicate that the dust is not hot enough to heat the gas to observed temperatures. A simple cloud model with a radiation field composed of flux HD 147889, S1, and Sco OB2 associations predicts the observed IRAS 60 to 100 micron in-band flux ratios for a mean cloud density n(H2) = 1400. Flattened 12 and 25 micron observations show much extended emission in these bands, suggesting stochastic heating of very small grains or large molecules.
Reactor wall in thermonuclear device
International Nuclear Information System (INIS)
Shibui, Masanao.
1988-01-01
Purpose: To always monitor the life of armours in reactor walls and automatically shutdown the reactor if it should be operated in excess of the limit of use. Constitution: Monitoring material of lower melting point than armours (for example beryllium pellets) as one of the reactor wall constituents of a thermonuclear device are embedded in a region leaving the thickness corresponding to the allowable abrasion of the armour. In this structure, if the armours are abrased due to particle loads of a plasma and the abrasion exceeds a predetermined allowable level, the monitoring material is exposed to the plasma and melted and evaporated. Since this can be detected by impurity monitors disposed in the reactor, it is possible to recognize the limit for the working life of the armours. If the thermonuclear reactor should be operated accidentally exceeding the life of the armours, since a great amount of the monitoring materials have been evaporated, they flow into the plasma to increase the plasma radiation loss thereby automatically eliminate the plasma. (K.M.)
Inertial thermonuclear fusion by laser
International Nuclear Information System (INIS)
Watteau, J.P.
1993-12-01
The principles of deuterium tritium (DT) magnetic or inertial thermonuclear fusion are given. Even if results would be better with heavy ions beams, most of the results on fusion are obtained with laser beams. Technical and theoretical aspects of the laser fusion are presented with an extrapolation to the future fusion reactor. (A.B.). 34 refs., 17 figs
Laser thermonuclear fusion with force confinement of hot plasma
International Nuclear Information System (INIS)
Korobkin, V.V.; Romanovsky, M.Y.
1994-01-01
The possibility of the utilization of laser radiation for plasma heating up to thermonuclear temperatures with its simultaneous confinement by ponderomotive force is investigated. The plasma is located inside a powerful laser beam with a tubelike section or inside a cavity of duct section, formed by several intersecting beams focused by cylindrical lenses. The impact of various physical processes upon plasma confinement is studied and the criteria of plasma confinement and maintaining of plasma temperature are derived. Plasma and laser beam stability is considered. Estimates of laser radiation energy necessary for thermonuclear fusion are presented
International Nuclear Information System (INIS)
Tezuka, Masaru.
1993-01-01
Protrusions and recesses are formed to a vacuum vessel and toroidal magnetic coils, and they are engaged. Since the vacuum vessel is generally supported firmly by a rack or the like by support legs, the toroidal magnetic field coils can be certainly supported against tumbling force. Then, there can be attained strong supports for the toroidal magnetic field coils, in addition to support by wedges on the side of inboard and support by share panels on the side of outboard, capable of withstanding great electromagnetic forces which may occur in large-scaled next-generation devices. That is, toroidal magnetic field coils excellent from a view point of deformation and stress can be obtained, to provide a thermonuclear device of higher reliability. (N.H.)
A Game Theoretic Model of Thermonuclear Cyberwar
Energy Technology Data Exchange (ETDEWEB)
Soper, Braden C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
2017-08-23
In this paper we propose a formal game theoretic model of thermonuclear cyberwar based on ideas found in [1] and [2]. Our intention is that such a game will act as a first step toward building more complete formal models of Cross-Domain Deterrence (CDD). We believe the proposed thermonuclear cyberwar game is an ideal place to start on such an endeavor because the game can be fashioned in a way that is closely related to the classical models of nuclear deterrence [4–6], but with obvious modifications that will help to elucidate the complexities introduced by a second domain. We start with the classical bimatrix nuclear deterrence game based on the game of chicken, but introduce uncertainty via a left-of-launch cyber capability that one or both players may possess.
Application of controlled thermonuclear reactor fusion energy for food production
International Nuclear Information System (INIS)
Dang, V.D.; Steinberg, M.
1975-06-01
Food and energy shortages in many parts of the world in the past two years raise an immediate need for the evaluation of energy input in food production. The present paper investigates systematically (1) the energy requirement for food production, and (2) the provision of controlled thermonuclear fusion energy for major energy intensive sectors of food manufacturing. Among all the items of energy input to the ''food industry,'' fertilizers, water for irrigation, food processing industries, such as beet sugar refinery and dough making and single cell protein manufacturing, have been chosen for study in detail. A controlled thermonuclear power reactor was used to provide electrical and thermal energy for all these processes. Conceptual design of the application of controlled thermonuclear power, water and air for methanol and ammonia synthesis and single cell protein production is presented. Economic analysis shows that these processes can be competitive. (auth)
The ''Dolphin'' power laser installation for spherical thermonuclear target heating
International Nuclear Information System (INIS)
Basov, N.G.; Bykovskij, N.E.; Danilov, A.E.
1978-01-01
12-channel laser installation the ''Dolphin'' for thermonuclear target heating in the radiation spheric geometry has been developed to carry out series of physical investigations of laser-thermonuclear plasma system, optimization of target heating conditions and obtaining a comparatively large value of thermonuclear output in ratio to the energy of absorbed light radiation in the target. The description of installation main elements, consisting of the following components, is given: 1)neodymium laser with the maximum permissible radiation energy of 10kJ, with light pulse duration of 10 -10 /10 -9 c and radiation divergence of approximately 5x10 -4 rad; 2)vacuum chamber, where laser radiation interaction with plasma takes place; 3)diagnostic means of laser and plasma parameters and 4)focus system. The focus system provides a high degree of target spherical radiation symmetry at current maximum density on its surface of approximately 10 15 W/cm 2
Controlled thermonuclear fusion. Present state and prospective
International Nuclear Information System (INIS)
Consoli, T.
1976-01-01
The interest of thermonuclear fusion for energy production is underlined. The present state of the research in this field is presented, emphasis being given to Tokamak configurations. The problems concerning confinement and additional heating in these devices are presented [fr
Direct conversion of nuclear energy into radiation: New direction in thermonuclear laser fusion
International Nuclear Information System (INIS)
Babaev, Yu.N.; Vedenov, A.A.; Filyukov, A.A.
1995-01-01
In investigations dealing with thermonuclear fusion, a radical new direction appeared some time ago, namely the direct conversion of nuclear and thermonuclear energy into radiation energy. This paper reviews early work on this topic in Russia and the United States and discusses some recent new directions
1D thermonuclear model for x-ray transients
International Nuclear Information System (INIS)
Wallace, R.K.
1982-01-01
The thermonuclear evolution of a 1.41 M solar mass neutron star, with a radius of 14.3 km, accreting various mixtures of hydrogen, helium, and heavy elements at rates of 10 -11 to 10 -10 M solar mass/yr is examined, in conjunction with S.E. Woosley and T.A. Weaver, using a one-dimensional numerical model. We have ignored any effects due to general relativity or magnetic fields. Two cases shall be discussed. In both models, the accretion rate is such that the hydrogen shell burns to helium in steady state, with the hydrogen burning stabilized by the β-limited CNO cycle. A thick helium shell is produced, which is eventually ignited under extremely degenerate conditions, producing a thermonuclear runaway
International Nuclear Information System (INIS)
Cristea, G.
1975-01-01
The neutron problems are discussed of the thermonuclear reactor controlled by the rate of the fission reactions. The results obtained by rolling the DTF-4 program in a spherical geometry in the case of an ''external source'' problem permit to draw conclusions concerning the problems of the neutronics system of this thermonuclear reactor type. A relation is deduced for estimating the coefficient of back-reflection of the neutrons within the thermonuclear plasma and the focussion system is discussed of the neutronics of this reactor type
Sonoluminescence, shock waves, and micro-thermonuclear fusion
International Nuclear Information System (INIS)
Moss, W.C.; Clarke, D.B.; White, J.W.; Young, D.A.
1995-08-01
We have performed numerical hydrodynamic simulations of the growth and collapse of a sonoluminescing bubble in a liquid. Our calculations show that spherically converging shock waves are generated during the collapse of the bubble. The combination of the shock waves and a realistic equation of state for the gas in the bubble provides an explanation for the measured picosecond optical pulse widths and indicates that the temperatures near the center of the bubble may exceed 3O eV. This leads naturally to speculation about obtaining micro-thermonuclear fusion in a bubble filled with deuterium (D 2 ) gas. Consequently, we performed numerical simulations of the collapse of a D 2 bubble in D 2 0. A pressure spike added to the periodic driving amplitude creates temperatures that may be sufficient to generate a very small, but measurable number of thermonuclear D-D fusion reactions in the bubble
Insulation structure of thermonuclear device
International Nuclear Information System (INIS)
Suzuki, Takayuki; Usami, Saburo; Tsukamoto, Hideo; Kikuchi, Mitsuru
1998-01-01
The present invention provides an insulating structure of a thermonuclear device, in which insulation materials between toroidal coils are not broken even if superconductive toroidal coils are used. Namely, a tokamak type thermonuclear device of an insulating structure type comprises superconductive toroidal coils for confining plasmas arranged in a circular shape directing the center each at a predetermined angle, and the toroidal coils are insulated from each other. The insulation materials are formed by using a biaxially oriented fiber reinforced plastics. The contact surface of the toroidal coils and the insulating materials are arranged so that they are contact at a woven surface of the fiber reinforced plastics. Either or both of the contact surfaces of the fiber reinforced plastics and the toroidal coils are coated with a high molecular compound having a low friction coefficient. With such a constitution, since the interlayer shearing strength of the biaxially oriented fiber reinforced plastics is about 1/10 of the compression strength, the shearing stress exerted on the insulation material is reduced. Since a static friction coefficient on the contact surface is reduced to provide a structure causing slipping, shearing stress does not exceeds a predetermined limit. As a result, breakage of the insulation materials between the toroidal coils can be prevented. (I.S.)
First wall of thermonuclear device
International Nuclear Information System (INIS)
Kizawa, Makoto; Koizumi, Makoto; Nishihara, Yoshihiro.
1990-01-01
The first wall of a thermonuclear device is constituted with inner wall tiles, e.g. made of graphite and metal substrates for fixing them. However, since the heat expansion coefficient is different between the metal substrates and intermediate metal members, thermal stresses are caused to deteriorate the endurance of the inner wall tiles. In view of the above, low melting metals are disposed at the portion of contact between the inner wall tiles and the metal substrates and, further, a heat pipe structure is incorporated into the metal substrates. Under the thermal load, for example, during operation of the thermonuclear device, the low melting metals at the portion of contact are melted into liquid metals to enhance the state of contact between the inner wall tiles and the metal substrate to reduce the heat resistance and improve the heat conductivity. Even if there is a difference in the heat expansion coefficient between the inner wall tiles and the metal substrates, neither sharing stresses not thermal stresses are caused. Further, since the heat pipe structure is incorporated into the metal substrates, the lateral unevenness of the temperature in the metal substrates can be eliminated. Thus, the durability of the inner wall tiles can be improved. (N.H.)
The laser thermonuclear fusion
International Nuclear Information System (INIS)
Coutant, J.; Dautray, R.; Decroisette, M.; Watteau, J.P.
1987-01-01
Principle of the thermonuclear fusion by inertial confinement: required characteristics of the deuterium-tritium plasma and of the high power lasers to be used Development of high power lasers: active media used; amplifiers; frequency conversion; beam quality; pulse conditioning; existing large systems. The laser-matter interaction: collision and collective interaction of the laser radiation with matter; transport of the absorbed energy; heating and compression of deuterium-tritium; diagnoses and their comparison with the numerical simulation of the experiment; performances. Conclusions: difficulties to overcome; megajoule lasers; other energy source: particles beams [fr
International Nuclear Information System (INIS)
Oosaki, Osamu; Masuda, Kenju.
1980-01-01
Purpose: To provide excellent electric properties and high reliability in a thermonuclear device by improving a current collecting board connected to a coil device. Constitution: A current collecting board element perforated with an opening for enserting a connecting terminal is sized to be inserted into a plating tank, and is surface treated in the plating tank. Only the current collecting board element preferably surface treated is picked up. A plurality of such current collecting board elements are connected and welded to form a large current collecting board. In this manner, the current collecting board having several m 2 to several ten order m 2 in area can be obtained as preferably surface treated at the connecting terminal hole. The current collecting board element can be determined in shape with the existing facility without increasing the size of a surface treating tank. (Kamimura, M.)
Thermal insulation layer for the vacuum containers of a thermonuclear device
International Nuclear Information System (INIS)
Nishikawa, Masana; Yamada, Masao; Kameari, Akihisa; Niikura, Setsuo.
1980-01-01
Purpose: To prevent temperature rise of a thermal insulation layer for a vacuum container of a thermonuclear device higher than allowable value when irradiated by neutron by constructing the layer of a cooling unit in thermal insulation material. Constitution: A metal plate attached with cooling pipes is buried in a thermal insulation material forming a thermal insulation layer to form the layer provided between a vacuum container of a thermonuclear device and a shield. (Yoshihara, H.)
Fast fission assisted ignition of thermonuclear microexplosions
International Nuclear Information System (INIS)
Winterberg, F.
2006-01-01
It is shown that the requirements for fast ignition of thermonuclear microexplosions can be substantially relaxed if the deuterium-tritium (DT) hot spot is placed inside a shell of U-238 (Th-232). An intense laser - or particle beam-projected into the shell leads to a large temperature gradient between the hot DT and the cold U-238 (Th-232), driving thermomagnetic currents by the Nernst effect, with magnetic fields large enough to entrap within the hot spot the α-particles of the DT fusion reaction. The fast fission reactions in the U-238 (Th-232) shell implode about 1/2 of the shell onto the DT, increasing its density and reaction rate. With the magnetic field generated by the Nernst effect, there is no need to connect the target to a large current carrying transmission line, as it is required for magnetized target fusion, solving the so-called ''stand off'' problem for thermonuclear microexplosions. (orig.)
International Nuclear Information System (INIS)
1995-01-01
This book the study on isotopic hydrology in El Berrocal, Toledo (Spain). The special topic was the study about the tritium of springs with thermonuclear source. The study are articulated in 3 chapter: 1.- Chemical analysis of wastes 2.- Tritium with thermonuclear source 3.- Human resources
International Nuclear Information System (INIS)
Kajiura, Soji.
1984-01-01
Purpose: To suppress the generation of electromagnetic forces and improve the strength of a vacuum container for sealing plasmas and of a support frame for covering the coils disposed around the periphery of the vacuum container. Constitution: Either one of the vacuum container or the support frame is made of a composite material, whose first material has low radioactivatability and the second has low radioactivatability and stronger electrical resistance than that of the first; therein, with the first material being disposed on the surface. The damage caused by neutrons resulted from thermonuclear reaction can be extremely small since the constituent is made of the material having the low radioactivatability. Further, eddy current does not occurs in the second material, but in the first material only in case magnetic fields change rapidly, whereby the electromagnetic force resulted in this portion is decreased as a whole. (Moriyama, K.)
International Nuclear Information System (INIS)
Suzuki, Shohei
1988-01-01
Purpose: To obtain high voltage withstanding current introduction terminals not suffering from the effects of the reduction in the creeping voltage withstanding property by the application of magnetic fields. Constitution: This invention concerns a current introduction terminal for supplying electric current to coils for use in a thermonuclear device, etc. The conductor of the current introduction terminal on the side of vacuum is completely covered with solid insulator. This can eliminate the portion of securing the creeping withstanding voltage. The voltage withstanding characteristics of the solid insulator covering the portion of the conductor on the side of vacuum has a constant value irrespective of the atmosphere or the absence or presence of magnetic fields. Accordingly, the voltage withstanding characteristics of the current introduction terminal on the side of vacuum are determined by the property of the solid insulator, which is not reduced by the application of magnetic fields. (Ikeda, J.)
Thermonuclear fusion: Current status and future prospects
International Nuclear Information System (INIS)
Bruhns, H.; Maisonnier, Ch.
1992-01-01
Thermonuclear Fusion holds great promises for becoming an important energy source for the future. Fusion research and development is undertaken in al major countries of the world. The European Community pursues fusion in a large programme which embraces all R and D in the field of magnetic confinement fusion in the Member States, and to which Sweden and Switzerland are fully associated. The long-term objective of the programme is the joint creation of safe, environmentally sound prototype reactors. The main R and D line of the Community Fusion Programme is fusion by toroidal magnetic confinement on the basis of the Tokamak concept. Some related concepts are also studied which possibly could offer advantages for a reactor, and keep-in-touch activities exist for other approaches. Several small and medium sized specialised devices in Associated Laboratories have been built by the Community Fusion Programme as well as the Joint European Torus (JET Joint Undertaking) which is the largest and the most successful fusion device in the world. Recently, fusion power in the megawatt range has been achieved in JET. The long timescale and the large effort needed for the development of fusion as an energy source have been important elements to foster international collaboration. Engineering Design Activities for an International Thermonuclear Experimental Reactor (ITER) are undertaken, under the auspices of the IAEA, by the European Community, Japan, the Russian Federation and the United States of America. The objective of ITER is to achieve self-sustained thermonuclear burn and its control under long-pulse operation and to provide basic data for the engineering of a demonstration fusion reactor. (author)
Study on structural materials used in thermonuclear fusion technology
International Nuclear Information System (INIS)
Billa, R.; Amaral, D.
1995-01-01
The main problem related to the construction of a thermonuclear fusion reactor is the absence of suitable materials for the process, concerning to temperature limits, heat flux and life time. The first wall is the most critical part of the structure, being submitted to radiation effects, ionic corrosion and coolant, besides thermal fatigue and tension produced by cyclical burning. The AISI 316(17-12SPH) stainless steel is used as structural material, which has a wide known database. This work proposes an alternative material study to be used in the future thermonuclear fusion reactors. As a option a study on the utilization of Cr-Mn(Fe-17 Mn-10 Cr-0,1 C) steels and their alloy variations is presented
Some safety considerations in laser-controlled thermonuclear reactors. Final report
International Nuclear Information System (INIS)
Botts, T.E.; Breton, D.; Chan, C.K.; Levy, S.I.; Sehnert, M.; Ullman, A.Z.
1978-07-01
A major objective of this study was to identify potential safety questions for laser controlled thermonuclear reactors. From the safety viewpoint, it does not appear that the actual laser controlled thermonuclear reactor conceptual designs present hazards very different than those of magnetically confined fusion reactors. Some aspects seem beneficial, such as small lithium inventories, and the absence of cryogenic devices, while other aspects are new, for example the explosion of pressure vessels and laser hazards themselves. Major aspects considered in this report include: (a) general safety considerations, (b) tritium inventories, (c) system behavior during loss of flow accidents, and (d) safety considerations of laser related penetrations
International Nuclear Information System (INIS)
Yasutomi, Yoshiyuki; Nakagawa, Moroo; Sawai, Yuichi; Chiba, Akio; Suzuki, Yasutaka.
1997-01-01
Silicon composited with reinforcing metals is used for a divertor cooling substrate having an effect as a cooling tube to provide a silicon base composite material having increased electric resistance and toughness. The blending ratio of reinforcing materials in the form of granules, whiskers or long fibers is controlled in order to control heat conductivity, electric resistivity and mechanical performances. The divertor cooling substrate comprising the silicon base composite material is integrated with a plasma facing material. The production method therefor includes ordinary metal matrix composite forming methods such as powder metallurgy, melting penetration method, high pressure solidification casting method, centrifugal casting method and vacuum casting method. Since the cooling plate is constituted with the light metal and highly electric resistant metal base composite material, sharing force due to eddy current can be reduced, and radiation exposure can be minimized. Accordingly, a cooling structure for a thermonuclear reactor effective for the improvement of environmental problems caused by waste disposal can be attained. (N.H.)
International Nuclear Information System (INIS)
Rybalko, V.F.
1978-01-01
Phenomena that can introduce a controlling contribution into the erosion of the first wall surface in thermonuclear reactor are reviewed. Considered are the main characteristics of the physical disintegration: dependence of the disintegration coefficient upon the energy and the incidence angle of the bombarding particles, upon the atomic number of the material of the target and the type of bombarding particles. Stressed is the lack of reliable data on the disintegration of materials by light ions, which are of a maximum interest in relation to the controlled thermonuclear synthesis. The chemical disintegration and some regularities of it for the carbon-hydrogen and carbon-oxygen systems are discussed briefly. Listed are the main properties of blistering and its contribution to the erosion of crystalline surfaces
Repairing method and device for thermonuclear device
International Nuclear Information System (INIS)
Sakurai, Akiko; Masumoto, Hiroshi; Tachikawa, Nobuo.
1995-01-01
The present invention provides a method of and a device for repairing a first wall and a divertor disposed in a vacuum vessel of a thermonuclear device. Namely, an armour tile of the divertor secured, by a brazing material, in a vacuum vessel of the thermonuclear device in which high temperature plasmas of deuterium and tritium are confined to cause fusion reaction is induction-heated or heated by microwaves to melt the brazing material. Only the armour tile is thus exchanged by its attachment/detachment. This device comprises, in the vacuum vessel, an armour tile attaching/detaching manipulator and a repairing manipulator comprising a heating manipulator having induction heating coils at the top end thereof. Induction heating coils are connected to an AC power source. According to the present invention, the armour tile is exchanged without taking the divertor out of the vacuum vessel. Therefore, cutting of a divertor cooling tube for taking the divertor out of the vacuum vessel and re-welding of the divertor for attaching it to the vacuum vessel again are no more necessary. (I.S.)
Thermonuclear pulsors engineering
International Nuclear Information System (INIS)
Ramos, Ruben F.
2001-01-01
The neutronic radiation has several applications, such as activation analysis of different substances, neutron radiography, molecular structures study, cancer therapy, humidity detection and materials surface treatment, among others. The main obstacle for these applications is the generation of neutronic beams. Nuclear reactors, isotopic sources and particle accelerators are neutron generators commonly used. They share the disadvantages of being non-portable, and quite expensive. This work is mainly focused on the development of neutron generators suitable to the applications mentioned before, in which traditional generators are non-applicable. The main characteristics should be transportability and to be non-contaminating, which would allow in-situ tests. Plasma focus generators, which produce neutron pulses by thermonuclear fusion reactions, satisfy these requirements and are economically convenient. This last feature would assure competitively in the neutron sources market. (author)
Critical density and disruptions in α-heated thermonuclear Tokamak discharges
International Nuclear Information System (INIS)
Cotsaftis, M.; Firestone, M.; Wang, P.K.C.
1985-02-01
The study of existence of a critical density limit has been extended to the case of thermonuclear α-particle heated regime. To proceed, a 0-D model including sources and sinks affecting the evolution of ion and electron temperatures and of electron and α-particle densities with auxiliary neutral injected power has been developed. It is mainly shown when considering a Tokamak machine adapted for thermonuclear performances that, like in previous case, there is a critical density above which no other equilibrium point than 0 does exist. Temperatures then drop down the 0 past this critical value, leading to disruption. Analytic expression for critical density is given in terme of auxiliary projected power Psup(N). For Psup(N)=0, critical density value is low, but it increases fast enough for small Psup(N) to give a large safety margin once Psup(N) is moderate, much below the power required for reaching thermonuclear regime. So it is only at shutdown power periods that critical density can be crossed. But in this case, the heat content of particles in the discharge can significantly contribute to smooth out the temperature drop off. This typically operates up to the point where, due to change in magnetic islands configuration resulting from profile modification due to energy release at critical density crossing, heat transport doubles. Then on a fast thermal diffusion time scale, temperature drops now to a new equilibrium value, which can be made above the limiting value for which position control system of the plasma cannot forbid the plasma current to drop off itself, which is the important phenomenon of disruption. So on top of controls previously discussed, it is possible to use the α-particles themselves as a new preventive control against disruptions, making this phenomenon less dangerous for thermonuclear regime operation
Italy, EURATOM and Early Research on Controlled Thermonuclear Fusion (1957-1962)
International Nuclear Information System (INIS)
Curli, Barbara
2017-01-01
This chapter traces the early origins of European collaboration in controlled thermonuclear fusion research, within the larger picture of Cold War nuclear policy in the late 1950s-early 1960s, and as a consequence of the signing of the EURATOM treaty in 1957. It then presents some preliminary findings on the Association contract which was signed in 1960 between EURATOM and Italy, in order to carry out research in controlled thermonuclear fusion at the then newly created 'Laboratori nazionali di Frascati', near Rome, within the framework of the Comitato Nazionale Energia Nucleare (CNEN), the Italian civilian nuclear energy agency.
Atypical Thermonuclear Supernovae from Tidally Crushed White Dwarfs
International Nuclear Information System (INIS)
Rosswog, S.; Ramirez-Ruiz, E.; Hix, William Raphael
2008-01-01
Suggestive evidence has accumulated that intermediate mass black holes (IMBHs) exist in some globular clusters. Some stars will inevitably wander sufficiently close to the hole to suffer a tidal disruption. IMBHs can disrupt not only solar-type stars but also compact white dwarf stars. We investigate the fate of white dwarfs that approach the hole close enough to be disrupted and compressed to such an extent that explosive nuclear burning is triggered. Based on a precise modeling of the gas dynamics together with the nuclear reactions, it is argued that thermonuclear ignition is a natural outcome for white dwarfs of all masses passing well within the tidal radius. A good fraction of the star is accreted, yielding high luminosities that persist for up to a year. A peculiar, underluminous thermonuclear explosion accompanied by a soft X-ray transient signal would, if detected, be a compelling testimony for the presence of an IMBH
International Nuclear Information System (INIS)
2001-01-01
Theses of reports, presented at the 28th Conference on the plasma physics and controlled thermonuclear synthesis (Zvenigorod, 19-23 February 2001) are published. 246 reports were heard at the following sections: magnetic confinement, theory and experiments; inertial thermonuclear synthesis; plasma processes and physics of gas-discharge plasma; physical bases of plasma technologies. 17 reports had the summarizing character [ru
Brazilian programme for plasma physics and controlled thermonuclear fusion
International Nuclear Information System (INIS)
Chian, A.C.L.; Reusch, M.F.; Nascimento, I.C.; Pantuso-Sudano, J.
1992-01-01
A proposal for a National Programme of Plasma Physics and Controlled Thermonuclear Fusion in Brazil is presented, aimimg the dissemination of the researchers thought in plasma physics for the national authorities and the scientific community. (E.O.)
Analysis of induction phenomena in thermonuclear experiments
International Nuclear Information System (INIS)
Deeds, W.E.; Dodd, C.V.
1976-01-01
Many of the problems involving transients induced by changing currents in the large coils of thermonuclear machines are identical to those arising in nondestructive testing by eddy currents. There are three chief methods used for calculating such induction phenomena: analytical boundary-value solutions, relaxation or iteration techniques, and model experiments. Some of the results obtained by each of these methods are described below
Shock Ignition of Thermonuclear Fuel with High Areal Density
International Nuclear Information System (INIS)
Betti, R.; Zhou, C. D.; Anderson, K. S.; Theobald, W.; Solodov, A. A.; Perkins, L. J.
2007-01-01
A novel method by C. Zhou and R. Betti [Bull. Am. Phys. Soc. 50, 140 (2005)] to assemble and ignite thermonuclear fuel is presented. Massive cryogenic shells are first imploded by direct laser light with a low implosion velocity and on a low adiabat leading to fuel assemblies with large areal densities. The assembled fuel is ignited from a central hot spot heated by the collision of a spherically convergent ignitor shock and the return shock. The resulting fuel assembly features a hot-spot pressure greater than the surrounding dense fuel pressure. Such a nonisobaric assembly requires a lower energy threshold for ignition than the conventional isobaric one. The ignitor shock can be launched by a spike in the laser power or by particle beams. The thermonuclear gain can be significantly larger than in conventional isobaric ignition for equal driver energy
Shock ignition of thermonuclear fuel with high areal density.
Betti, R; Zhou, C D; Anderson, K S; Perkins, L J; Theobald, W; Solodov, A A
2007-04-13
A novel method by C. Zhou and R. Betti [Bull. Am. Phys. Soc. 50, 140 (2005)] to assemble and ignite thermonuclear fuel is presented. Massive cryogenic shells are first imploded by direct laser light with a low implosion velocity and on a low adiabat leading to fuel assemblies with large areal densities. The assembled fuel is ignited from a central hot spot heated by the collision of a spherically convergent ignitor shock and the return shock. The resulting fuel assembly features a hot-spot pressure greater than the surrounding dense fuel pressure. Such a nonisobaric assembly requires a lower energy threshold for ignition than the conventional isobaric one. The ignitor shock can be launched by a spike in the laser power or by particle beams. The thermonuclear gain can be significantly larger than in conventional isobaric ignition for equal driver energy.
International Nuclear Information System (INIS)
Takano, Hirohisa; Nakamoto, Kazunari; Hanai, Satoshi.
1984-01-01
Purpose: To provide coils of high mechanical strength for use at the center of a torus type thermonuclear device. Constitution: A plurality of copper plates having cooling holes and bolt holes and insulation paper sheets of the same shape are prepared. The copper plate is different from the insulation paper sheet only in that the position-phase angle of the opening portion is larger by 15 - 30 0 . The copper plates and the insulation paper sheets are alternately stacked by a required number of turns while displacing the angle, and then clamped by bolts to form a mechanically strong coil with no metallurgical joining. Further, since the insulation paper sheets are not present in the radial direction and only one insulation paper sheet is inserted for each turn in the direction of the coil height, the space occupied by the coil can be decreased. According to this invention, the magnetic flux density at the center of the device can be increased as compared with the conventional case to thereby apply a higher voltage on the side of plasmas. (Moriyama, K.)
Energy Technology Data Exchange (ETDEWEB)
Goncharov, German A [Russian Federal Nuclear Center ' All-Russian Scientific Research Institute of Experimental Physics' , Sarov, Nizhnii Novgorod Region (Russian Federation)
2005-11-30
On 22 November 1955, the Semipalatinsk test site saw the test of the first domestic two-stage thermonuclear RDS-37 charge. The charge operation was based on the principle of radiation implosion. The kernel of the principle consists in the radiation generated in a primary A-bomb explosion and confined by the radiation-opaque casing propagating throughout the interior casing volume and flowing around the secondary thermonuclear unit. The secondary unit experiences a strong compression under the irradiation, with a resulting nuclear and thermonuclear explosion. The RDS-37 explosion was the strongest of all those ever realized at the Semipalatinsk test site. It produced an indelible impression on the participants in the test. This document-based paper describes the genesis of the ideas underlying the RDS-37 design and reflects the critical moments in its development. The advent of RDS-37 was an outstanding accomplishment of the scientists and engineers of our country. (from the history of physics)
International Nuclear Information System (INIS)
Goncharov, German A
2005-01-01
On 22 November 1955, the Semipalatinsk test site saw the test of the first domestic two-stage thermonuclear RDS-37 charge. The charge operation was based on the principle of radiation implosion. The kernel of the principle consists in the radiation generated in a primary A-bomb explosion and confined by the radiation-opaque casing propagating throughout the interior casing volume and flowing around the secondary thermonuclear unit. The secondary unit experiences a strong compression under the irradiation, with a resulting nuclear and thermonuclear explosion. The RDS-37 explosion was the strongest of all those ever realized at the Semipalatinsk test site. It produced an indelible impression on the participants in the test. This document-based paper describes the genesis of the ideas underlying the RDS-37 design and reflects the critical moments in its development. The advent of RDS-37 was an outstanding accomplishment of the scientists and engineers of our country. (from the history of physics)
The LOFT perspective on neutron star thermonuclear bursts
DEFF Research Database (Denmark)
in ’t Zand, J.J.M.; Altamirano, D.; Ballantyne, D. R.
This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of thermonuclear X-ray bursts on accreting neutron stars. For a summary, we refer to the paper....
Atomic and molecular physics of controlled thermonuclear fusion
International Nuclear Information System (INIS)
Joachain, C.J.; Post, D.E.
1983-01-01
This book attempts to provide a comprehensive introduction to the atomic and molecular physics of controlled thermonuclear fusion, and also a self-contained source from which to start a systematic study of the field. Presents an overview of fusion energy research, general principles of magnetic confinement, and general principles of inertial confinement. Discusses the calculation and measurement of atomic and molecular processes relevant to fusion, and the atomic and molecular physics of controlled thermonuclear research devices. Topics include recent progress in theoretical methods for atomic collisions; current theoretical techniques for electron-atom and electronion scattering; experimental aspects of electron impact ionization and excitation of positive ions; the theory of charge exchange and ionization by heavy particles; experiments on electron capture and ionization by multiply charged ions; Rydberg states; atomic and molecular processes in high temperature, low-density magnetically confined plasmas; atomic processes in high-density plasmas; the plasma boundary region and the role of atomic and molecular processes; neutral particle beam production and injection; spectroscopic plasma diagnostics; and particle diagnostics for magnetic fusion experiments
Power supply for magnetic coils in thermonuclear devices
International Nuclear Information System (INIS)
Shimada, Ryuichi; Tamura, Sanae; Kishimoto, Hiroshi.
1981-01-01
Purpose: To decrease the load fluctuations in an external power supply, as well as to increase the operation efficiency capacity of thermonuclear devices. Constitution: Electrical power with the same frequency as that of a dynamo generator is supplied by a power supply-driving power source including a frequency converter and the like to DC converters for driving plasma-exciting and -controlling coils. At the same time, the electrical power from the frequency converter is supplied to the dynamo generator with flywheel to add accumulate energies to the EC converters. Accordingly, the energy for the great power pulses in a short time comprises the sum of the energy supplied from the dynamo generator with flywheel and the energy supplied continuously from the outside to eliminate the need of providing a stand-by period for the re-acceleration of the dynamo generator with flywheel even if the scale of the thermonuclear device is enlarged and energy consumed in one cycle is increased, whereby the decrease in the operation efficiency can be prevented and the capacity of the flywheel can be reduced. (Yoshino, Y.)
International Nuclear Information System (INIS)
2005-01-01
Theses of the reports, presented at the XXXII International conference on the plasma physics and controlled thermonuclear synthesis (Zvenigorod, 14-18 February 2005) are published. The total number of reports is 322, including 16 summarizing ones. The other reports are distributed by the following sections: magnetic confinement of high-temperature plasma (88 reports), inertial thermonuclear fusion (65), physical processes in low-temperature plasma (99) and physical bases of the plasma and beam technologies (54) [ru
Laczmanski, Lukasz; Lwow, Felicja; Mossakowska, Malgorzata; Puzianowska-Kuznicka, Monika; Szwed, Małgorzata; Kolackov, Katarzyna; Krzyzanowska-Swiniarska, Barbara; Bar-Andziak, Ewa; Chudek, Jerzy; Sloka, Natalia; Milewicz, Andrzej
2015-03-15
Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor. The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene. Rs10735810, rs1544410, rs7975232, and rs731236 polymorphisms of VDR, the serum sex hormone level, free estrogen index (FEI) and free androgen index (FAI) as well as vitamin D, were evaluated in 766 persons (362 women and 404 men) selected from 5695 Polish population, aged 65-90years from the PolSenior survey. We observed that women with GG (rs731236), TT (rs7975232), BB (rs1544410) and FF (rs10735810) genotypes were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism and in the GG (rs7975232), the BB (rs1544410), and the Ff (rs10735810) genotypes. In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed. Copyright © 2015 Elsevier B.V. All rights reserved.
DEFF Research Database (Denmark)
Enevold, Christian; Baslund, Bo; Linde, Louise
2014-01-01
Tocilizumab (TCZ), a monoclonal antibody targeting the human interleukin-6-receptor (IL-6R), is indicated for the treatment of rheumatoid arthritis (RA). We examined whether three IL6R single-nucleotide polymorphisms rs12083537, rs2228145 (formerly rs8192284), and rs4329505 with previously report...
D'Avolio, Antonio; De Nicolò, Amedeo; Cusato, Jessica; Ciancio, Alessia; Boglione, Lucio; Strona, Silvia; Cariti, Giuseppe; Troshina, Giulia; Caviglia, Gian Paolo; Smedile, Antonina; Rizzetto, Mario; Di Perri, Giovanni
2013-10-01
Functional variants rs7270101 and rs1127354 of inosine triphosphatase (ITPA) were recently found to protect against ribavirin (RBV)-induced hemolytic anemia. However, no definitive data are yet available on the role of no functional rs6051702 polymorphism. Since a simultaneous evaluation of the three ITPA SNPs for hemolytic anemia has not yet been investigated, we aimed to understand the contribution of each SNPs and its potential clinical use to predict anemia in HCV treated patients. A retrospective analysis included 379 HCV treated patients. The ITPA variants rs6051702, rs7270101 and rs1127354 were genotyped and tested for association with achieving anemia at week 4. We also investigated, using multivariate logistic regression, the impact of each single and paired associated polymorphism on anemia onset. All SNPs were associated with Hb decrease. The carrier of at least one variant allele in the functional ITPA SNPs was associated with a lower decrement of Hb, as compared to patients without a variant allele. In multivariate logistic regression analyses the carrier of a variant allele in the rs6051702/rs1127354 association (OR=0.11, p=1.75×10(-5)) and Hb at baseline (OR=1.51, p=1.21×10(-4)) were independently associated with protection against clinically significant anemia at week 4. All ITPA polymorphisms considered were shown to be significantly associated with anemia onset. A multivariate regression model based on ITPA genetic polymorphisms was developed for predicting the risk of anemia. Considering the characterization of pre-therapy anemia predictors, rs6051702 SNP in association to rs1127354 is more informative in order to avoid this relevant adverse event. Copyright © 2013 Elsevier B.V. All rights reserved.
International Nuclear Information System (INIS)
Suzuki, Shohei.
1980-01-01
Purpose: To improve the plasma confining efficiency in a thermonuclear device having magnet coils using super-conducting wires by decreasing the uneven magnetic field resulted from current supply terminals and wirings. Constitution: Current introduction terminals of magnet coils using superconducting wires are short circuitted with a superconducting short circuit wire. Upon supplying current to the coils, the resistance of the coils is rendered superconductive and the resistance of the short circuit wire is rendered normally conductive heated by a heater and the switch is closed. In this case, most parts of the current are flown through the resistance of the coils and the switch is opened when the current arrives at a predetermined value to render the resistance of the short circuit wire superconductive. Then, the current transfers from the thyristor power source to the resistance of the short circuit wire, whereby the resistance of the coils and that of the short circuit wire from a permanent current loop. In this conditions, since current flows through the short circuit wire and the coils and not to the current introduction terminals, no uniform magnetic field is generated. (Kawakami, Y.)
International Nuclear Information System (INIS)
Honda, Takuro; Maki, Koichi.
1997-01-01
The present invention provides a thermonuclear device, in which integrity of a measuring device is kept, the reactor wall temperature and wear of armour materials are monitored accurately even under intense radiation rays, so that the flow rate of coolants and plasma power can be controlled by using the signals. Infrared rays generated from the surface of the armour materials disposed on a first wall are detected to measure the reactor wall temperature. Coolant flow rate and plasma power are controlled based on the obtained reactor wall temperature. In addition, infrared rays generated from the back of the armour materials are detected to obtain the surface temperature in order to avoid intense radiation rays from plasmas. The coolant flow rate and the plasma power are controlled based on the obtained temperature on the surface of the reactor thereby controlling the temperature of the first wall and the armour material to 300degC or lower in a case of the first wall made of stainless steel and 1000degC or lower in a case of the armour material made of graphite. (I.S.)
Fabrication of an alumina torus for thermonuclear fusion containment
International Nuclear Information System (INIS)
Hauth, W.E.; Blake, R.D.; Dickinson, J.M.; Rutz, H.L.; Stoddard, S.D.
1978-05-01
A 235-cm-diam torus has been fabricated for plasma containment during thermonuclear fusion experiments. This 30-cm-diam torus consists of sixty 99.5%-alumina segments, 80% of which are assembled by forming vacuum-tight ceramic-to-ceramic seals. Selection of sealing materials and techniques are discussed
Feasibility studies of thermonuclear neutron capture synthesis of SHE
International Nuclear Information System (INIS)
Meldner, H.W.
1978-01-01
A variety of thermonuclear neutron sources and neutron capture targets were investigated for their potential of allowing signigicant production of heavy, perhaps superheavy, isotopes. The neutron sources considered range from inertial confinement microexplosives to (underground) macroexplosives. Optimal capture targets appear to be composites containing uranium and protactinium. 1 figure
Epidemiology of a thermonuclear bomb-burst over Nashville, Tennessee: a theoretic study
International Nuclear Information System (INIS)
Quinn, R.W.
1983-01-01
A thermonuclear bomb explosion over any city in the world would have a devastating effect on the population and environment. For those who survive, with or without injuries, life would become primitive with little or no uncontaminated food or water, and with inadequate housing, fuel, and medical care, resulting in a breakdown of family and interpersonal relationships. This theoretic study of the potential outcome of a thermonuclear bomb-burst over Nashville, Tennessee, discusses epidemiologically the wide range of medical and psychologic effects from the direct trauma of blast and fire, widespread epidemics of otherwise controlled disease, long-term chronic illness, genetic damage, and catastrophic environmental havoc
Investigation of the stationary-thermonuclear-reaction realization possibility in a tokamak device
International Nuclear Information System (INIS)
Kolesnichenko, Ya.I.; Reznik, S.N.; Fursa, A.D.
1976-01-01
The stationary (quasistationary) selfsustaining thermonuclear D-T reaction is shown to be possible in a toroidal device such as 'Tokamak' with large enough plasma radius. The stationary temperature of the plasma can be quite high. Thus when the transport processes are assumed to be neoclassical the temperature of the central part of a plasma colomn of radius approximately 10-200 cm in the stationary state is 70 keV.The stationary temperature distribution is reached spontaneously as a result of the thermal instability development if plasma is preheated to 10 keV. The stationary thermonuclear burning is also possible at lower temperatures if plasma energy balance is controlled
International Nuclear Information System (INIS)
Delpech, J.-F.; Fabre, Edouard.
1978-01-01
This paper is intended to describe the principle of inetia containment by laser and the research effort undertaken for this purpose. After having enumerated the principal thermonuclear reactions useful for fusion, the authors derive the rhoR criterion that characterizes inertia containment, as well as the Lawson criterion in the case of magnetic containment. The main physics problems involved in inertia containment by laser are enunciated and the article ends with a review of means resorted to in France and abroad for studying this problem. This review also reports C.N.R.S. bustling in this field, within the scope of competence of G.I.L.M. (Groupement de Recherches Coordonnees sur l'Interaction Laser-Matiere = Group for coordinated investigation of matter-laser interaction) established in Paris at the Ecole Polytechnique [fr
International Nuclear Information System (INIS)
Andreev, A.A.; Gus'kov, S.Yu.; Rozanov, V.B.; Il'in, D.V.; Levkovskij, A.A.; Sherman, V.E.
2001-01-01
On the basis of mathematical simulation of thermonuclear burning of DT-plasma of laser targets one calculated G factors of thermonuclear intensification for a space and a spark ignitions at various parameters of target plasma and igniters (both isobaric and isochoric). One calculated the critical parameters of igniters upon reaching of which the efficient thermonuclear burst with G ∼ 100 took place. It is shown that further increase of temperature and of dimensions of igniters does not practically affect the efficiency of DT-fuel burnup and independently of the way of ignition G value may be estimated using a simple asymptotic expression. At the same time the values of the critical parameters of igniters depend essentially on the way of ignition and on target parameters. One studied in detail the spark ignition with isochoric igniter. Thermal energy generated at absorption of supershort additional laser pulse is shown to be the key critical parameter for the optimal isochoric igniters. Critical parameters of this energy are calculated [ru
Divertor, thermonuclear device and method of neutralizing high temperature plasma
International Nuclear Information System (INIS)
Ikegami, Hideo.
1995-01-01
The thermonuclear device comprises a thermonuclear reactor for taking place fusion reactions to emit fusion plasmas, and a divertor made of a hydrogen occluding material, and the divertor is disposed at a position being in contact with the fusion plasmas after nuclear fusion reaction. The divertor is heated by fusion plasmas after nuclear fusion reaction, and hydrogen is released from the hydrogen occluding material as a constituent material. A gas blanket is formed by the released hydrogen to cool and neutralize the supplied high temperature nuclear fusion plasmas. This prevents the high temperature plasmas from hitting against the divertor, elimination of the divertor by melting and evaporation, and solve a problem of processing a divertor activated by neutrons. In addition, it is possible to utilize hydrogen isotopes of fuels effectively and remove unnecessary helium. Inflow of impurities from out of the system can also be prevented. (N.H.)
Exquisite Nova Light Curves from the Solar Mass Ejection Imager (SMEI)
Hounsell, R.; Bode, M. F.; Hick, P. P.; Buffington, A.; Jackson, B. V.; Clover, J. M.; Shafter, A. W.; Darnley, M. J.; Mawson, N. R.; Steele, I. A.; Evans, A.; Eyres, S. P. S.; O'Brien, T. J.
2010-01-01
We present light curves of three classical novae (KT Eridani, V598 Puppis, V1280 Scorpii) and one recurrent nova (RS Ophiuchi) derived from data obtained by the Solar Mass Ejection Imager (SMEI) on board the Coriolis satellite. SMEI provides near complete sky-map coverage with precision visible-light photometry at 102-minute cadence. The light curves derived from these sky maps offer unprecedented temporal resolution around, and especially before, maximum light, a phase of the nova eruption n...
The international thermonuclear reactor (ITER)
International Nuclear Information System (INIS)
Fowler, T.K.; Henning, C.D.
1987-01-01
Four governmental groups, representing Europe, Japan, USSR and U.S. met in March 1987 to consider a new international design of a magnetic fusion device for the 1990's. An interim group was appointed. The author gives a brief synopsis of what might be thought of as a draft charter. The starting point is the objective of the ITER device, which is summarized as demonstrating both scientific and technical feasibility of fusion. The paper presents an update on the current thinking and technical aspects for the International Thermonuclear Experimental Reactor (ITER). This covers not only what is happening in the U.S. but also some reports of preliminary thinking of the last technical work that occurred in Vienna
Paradowska-Gorycka, Agnieszka; Malinowski, Damian; Haladyj, Ewa; Olesinska, Marzena; Safranow, Krzysztof; Pawlik, Andrzej
2018-01-19
Rheumatoid arthritis (RA) is an autoimmune diseases, where different genetic variants in cytokine genes may play a pathogenic role. A GWAS in autoimmune diseases highlighted the IL-23R gene as a one of the susceptibility factors. We examined three candidate single nucleotide polymorphisms (SNPs) rs10889677, rs11209026 and rs2201841 of the IL-23R gene, as well as determined their possible association with RA in a Polish population. The IL-23R gene polymorphisms were genotyped for 422 RA patients and 348 healthy individuals using TaqMan SNP genotyping assay. The genotypes frequency did not deviate from HWE in each examined group. A comparison of the allele as well as genotype frequencies of the IL-23R polymorphisms under codominant, dominant and recessive genetic model revealed no significant differences between RA patients and healthy subjects. We also demonstrated that IL-23R rs2201841 and rs11209026 as well as rs11209026 and rs10889677 were in complete linkage disequilibrium (D'=1.0). Our genotype-phenotype analysis demonstrated that in carriers of rs10889677C and/or rs2201841A allele the RF, extra-articular manifestations and erosion were more frequent present than in patients with rs10889677A and/or rs2201841A allele, although this association was not significant. Present findings indicated that the autoimmune disease-associated genetic variants in IL-23R gene are not associated with RA in the Polish population. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.
International Nuclear Information System (INIS)
Vikhrev, V.V.; Rozanova, G.A.
1993-01-01
The development of the sausage instability in a z pinch is accompanied by the formulation of a high-temperature plasma. This high-temperature region initiates a wave of thermonuclear burning propagating along the pinch. A numerical solution of the MHD equations has been carried out, taking into account plasma energy losses through radiation and thermonuclear heating. Results of calculations on the growth of the sausage instability are presented for ρr = 0.23 g/cm 2 . It is accompanied by the development of a stable wave of thermonuclear burning. 12 refs., 4 figs
Thermonuclear model for γ-ray bursts
International Nuclear Information System (INIS)
Woosley, S.E.
1981-01-01
The evolution of magnetized neutron stars with field strengths of approx. 10 12 gauss that are accreting mass onto kilometer-sized polar regions at a rate of approx. 13 M 0 yr -1 is examined. Based on the results of one-dimensional calculations, one finds that stable hydrogen burning, mediated by the hot CNO-cycle, will lead to a critical helium mass in the range 10 20 to 10 22 g km -2 . Owing to the extreme degeneracy of the electron gas providing pressure support, helium burning occurs as a violent thermonuclear runaway which may propagate either as a convective deflagration (Type I burst) or as a detonation wave (Type II burst). Complete combustion of helium into 56 Ni releases from 10 38 to 10 40 erg km -2 and pushes hot plasma with β > 1 above the surface of the neutron star. Rapid expansion of the plasma channels a substantial fraction of the explosion energy into magnetic field stress. Spectral properties are expected to be complex with emission from both thermal and non-thermal processes. The hard γ-outburst of several seconds softens as the event proceeds and is followed by a period, typically of several minutes duration, of softer x-ray emission as the subsurface ashes of the thermonuclear explosion cool. In this model, most γ-ray bursts currently being observed are located at a distance of several hundred parsecs and should recur on a timescale of months to centuries with convective deflagrations (Type I bursts) being the more common variety. An explanation for Jacobson-like transients is also offered
Thermonuclear ignition in the next generation tokamaks
International Nuclear Information System (INIS)
Johner, J.
1989-04-01
The extrapolation of experimental rules describing energy confinement and magnetohydrodynamic - stability limits, in known tokamaks, allow to show that stable thermonuclear ignition equilibria should exist in this configuration, if the product aB t x of the dimensions by a magnetic-field power is large enough. Quantitative application of this result to several next-generation tokamak projects show that those kinds of equilibria could exist in such devices, which would also have enough additional heating power to promote an effective accessible ignition
Status report on controlled thermonuclear fusion
International Nuclear Information System (INIS)
1990-06-01
The International Fusion Research Council (IFRC), an advisory body to the International Atomic Energy Agency, reports on the current status of fusion; this report updates its 1978 status report. This report contains a General Overview and Executive Summary, and reports on all current approaches to fusion throughout the world; a series of technical reports is to be published elsewhere. This report is timely in that it not only shows progress which has occurred over the past, but interfaces with possible future devices, in particular the International Thermonuclear Experimental Reactor (ITER), whose conceptual design phase is nearing completion. 5 refs, 6 figs
Rates of the main thermonuclear reactions
International Nuclear Information System (INIS)
Abramovich, S.N.; Guzhovskii, B.Ya.; Dunaeva, S.A.; Fomushkin, E.F.
1992-01-01
The data on the cross sections of main thermonuclear reactions have been estimated with an account of the latest experimental results in a form of S-factor spline presentation. Based on this estimation, the reates of these reactions in 0.0001-1 MeV temperature range in the supposition of Maxwell distribution of relative velocities have been computed. The Maxwell-Boltzmann averaged -factors were calculated according to the table values of the reaction rates. Then the -factors were approximated with the 3 order spline-function. The necessity of the account of electron shielding and intramolecular movement at low temperatures is discussed (orig.)
International Nuclear Information System (INIS)
Warshaw, S I
2001-01-01
The rate of thermonuclear reactions in hot plasmas as a function of local plasma temperature determines the way in which thermonuclear ignition and burning proceeds in the plasma. The conventional model approach to calculating these rates is to assume that the reacting nuclei in the plasma are in Maxwellian equilibrium at some well-defined plasma temperature, over which the statistical average of the reaction rate quantity σv is calculated, where σ is the cross-section for the reaction to proceed at the relative velocity v between the reacting particles. This approach is well-understood and is the basis for much nuclear fusion and astrophysical nuclear reaction rate data. The Thermonuclear Data File (TDF) system developed at the Lawrence Livermore National Laboratory (Warshaw 1991), which is the topic of this report, contains data on the Maxwellian-averaged thermonuclear reaction rates for various light nuclear reactions and the correspondingly Maxwellian-averaged energy spectra of the particles in the final state of those reactions as well. This spectral information closely models the output particle and energy distributions in a burning plasma, and therefore leads to more accurate computational treatments of thermonuclear burn, output particle energy deposition and diagnostics, in various contexts. In this report we review and derive the theoretical basis for calculating Maxwellian-averaged thermonuclear reaction rates, mean particle energies, and output particle spectral energy distributions for these reactions in the TDF system. The treatment of the kinematics is non-relativistic. The current version of the TDF system provides exit particle energy spectrum distributions for two-body final state reactions only. In a future report we will discuss and describe how output particle energy spectra for three- and four-body final states can be developed for the TDF system. We also include in this report a description of the algorithmic implementation of the TDF
Coupling and absorption of lower-hybrid waves in a thermonuclear plasma
International Nuclear Information System (INIS)
Puri, S.; Tutter, M.
1975-01-01
The three important aspects, namely 1) accessibility, 2) matching and 3) absorption of the lower-hybrid waves in a thermonuclear plasma are studied under idealized but physically pertinent conditions within the framework of linearized theory. (orig.) [de
D+D thermonuclear fusion reactions with polarized particles
International Nuclear Information System (INIS)
Kozma, P.
1986-01-01
Polarization measurements from the 2 H(d, n) 3 He and 2 H(d, p) 3 H thermonuclear reactions at deuteron energies below 1 MeV are anayzed. Results of analysis enable to discuss the existence of 4 He excited states in the vicinity of d+d threshold energy as well as to extrapolate total cross-sections σ tot (d+d) into the region of very low energies
Overview of International Thermonuclear Experimental Reactor (ITER) engineering design activities*
Shimomura, Y.
1994-05-01
The International Thermonuclear Experimental Reactor (ITER) [International Thermonuclear Experimental Reactor (ITER) (International Atomic Energy Agency, Vienna, 1988), ITER Documentation Series, No. 1] project is a multiphased project, presently proceeding under the auspices of the International Atomic Energy Agency according to the terms of a four-party agreement among the European Atomic Energy Community (EC), the Government of Japan (JA), the Government of the Russian Federation (RF), and the Government of the United States (US), ``the Parties.'' The ITER project is based on the tokamak, a Russian invention, and has since been brought to a high level of development in all major fusion programs in the world. The objective of ITER is to demonstrate the scientific and technological feasibility of fusion energy for peaceful purposes. The ITER design is being developed, with support from the Parties' four Home Teams and is in progress by the Joint Central Team. An overview of ITER Design activities is presented.
The Influence of Stellar Spin on Ignition of Thermonuclear Runaways
Galloway, Duncan K.; in ’t Zand, Jean J. M.; Chenevez, Jérôme; Keek, Laurens; Sanchez-Fernandez, Celia; Worpel, Hauke; Lampe, Nathanael; Kuulkers, Erik; Watts, Anna; Ootes, Laura; The MINBAR collaboration
2018-04-01
Runaway thermonuclear burning of a layer of accumulated fuel on the surface of a compact star provides a brief but intense display of stellar nuclear processes. For neutron stars accreting from a binary companion, these events manifest as thermonuclear (type-I) X-ray bursts, and recur on typical timescales of hours to days. We measured the burst rate as a function of accretion rate, from seven neutron stars with known spin rates, using a burst sample accumulated over several decades. At the highest accretion rates, the burst rate is lower for faster spinning stars. The observations imply that fast (>400 Hz) rotation encourages stabilization of nuclear burning, suggesting a dynamical dependence of nuclear ignition on the spin rate. This dependence is unexpected, because faster rotation entails less shear between the surrounding accretion disk and the star. Large-scale circulation in the fuel layer, leading to enhanced mixing of the burst ashes into the fuel layer, may explain this behavior; further numerical simulations are required to confirm this.
Cross sections and thermonuclear reaction rates of proton-induced reactions on 37Cl
International Nuclear Information System (INIS)
Weber, R.O.; Tingwell, C.I.W.; Mitchell, L.W.; Sevior, M.E.; Sargood, D.G.
1984-01-01
The yields of γ-rays from the reactions of 37 Cl(p,γ) 38 Ar and 37 Cl(p,αγ) 34 S have been measured as a of bombarding energy over the ranges 0.65 - 2.15 MeV and 1.25 -2.15 MeV respectively, and the yield of neutrons from 37 Cl(p,n) 37 Ar from threshold to 2.50 MeV. The results are compared with global statistical-model calculations and thermonuclear reaction rates are calculated for the temperature range 5 x 10 8 - 10 10 K. The significance of these thermonuclear reaction rates for stellar nucleosynthesis calculations is discussed
International Nuclear Information System (INIS)
Kovrizhnykh, L.M.; Ivanov, V.A.; Nagaeva, M.L.; Aleksandrov, A.F.; Vorob'ev, V.S.; Ivanenkov, G.V.; Meshcheryakov, A.I.
2004-01-01
Theses of the reports of the 31th Zvenigorod Conference on the physics and controlled thermonuclear synthesis, presented by Russian and foreign scientists, are published. The total number of reports is 258, namely, summarizing ones 16, magnetic confinement of high temperature plasma - 98, inertial thermonuclear synthesis - 44, physical processes in low temperature plasma - 58, physical bases of plasma and beam technologies - 42 [ru
Oscillations During Thermonuclear X-ray Bursts: A New Probe of Neutron Stars
Strohmayer, Tod E.; White, Nicholas E. (Technical Monitor)
2002-01-01
Observations of thermonuclear (also called Type 1) X-ray bursts from neutron stars in low mass X-ray binaries (LMXB) with the Rossi X-ray Timing Explorer (RXTE) have revealed large amplitude, high coherence X-ray brightness oscillations with frequencies in the 300 - 600 Hz range. Substantial spectral and timing evidence point to rotational modulation of the X-ray burst flux as the cause of these oscillations, and it is likely that they reveal the spin frequencies of neutron stars in LMXB from which they are detected. Here we review the status of our knowledge of these oscillations and describe how they can be used to constrain the masses and radii of neutron stars as well as the physics of thermonuclear burning on accreting neutron stars.
Plasma and controlled thermonuclear reaction
International Nuclear Information System (INIS)
Kapitsa, P.
1980-01-01
The principle and prospects are given of three methods of achieving controlled thermonuclear reaction. The original and so far most promising TOKAMAK method is presented invented in the USSR. Another method is the heating of a sphere about 1 mm in diameter from a mixture of deuterium and tritium by focused laser light from all sides. The third method consists in continuous plasma heating. A rope-like plasma discharge at a temperature of more than a million K results in the gas from microwave oscillations. The discharge is placed in a magnetic field and the ion temperature is increased by magneto-acoustic waves. A reactor is proposed operating on this principle and problems are pointed out which will have to be resolved. (M.S.)
Plasma and controlled thermonuclear reaction
Energy Technology Data Exchange (ETDEWEB)
Kapitsa, P
1980-06-01
The principle and prospects are given of three methods of achieving controlled thermonuclear reaction. The original and so far most promising TOKAMAK method is presented invented in the USSR. Another method is the heating of a sphere about 1 mm in diameter from a mixture of deuterium and tritium by focused laser light from all sides. The third method consists in continuous plasma heating. A rope-like plasma discharge at a temperature of more than a million K results in the gas from microwave oscillations. The discharge is placed in a magnetic field and the ion temperature is increased by magneto-acoustic waves. A reactor is proposed operating on this principle and problems are pointed out which will have to be resolved.
What is the Plasma Focus Thermonuclear Pulsors Technology?
International Nuclear Information System (INIS)
Ramos, R.; Gonzalez, J.; Moreno, C.; Clausse, A.
2003-01-01
In this paper we describe a type of neutron generators, called Plasma Focus, which is suitable to several applications, where traditional generators are non-applicable.The main characteristics are its transportability and to be non-contaminating, which would allow in-situ tests.The Plasma Focus, produces neutron pulses by thermonuclear fusion reactions, satisfy these requirements and it is comparatively non expensive.This last feature would assure competitivity in the neutron sources market
Energy Technology Data Exchange (ETDEWEB)
Bayer, Ch.; Juraszek, D
2001-07-01
Inertial Confinement Fusion (ICF) is an approach to thermonuclear fusion in which the fuel contained in a spherical capsule is strongly compressed and heated to achieve ignition and burn. The released thermonuclear energy can be much higher than the driver energy, making energetic applications attractive. Many complex physical phenomena are involved by the compression process, but it is possible to use simple analytical models to analyze the main critical points. We first determine the conditions to obtain fuel ignition. High thermonuclear gains are achieved if only a small fraction of the fuel called hot spot is used to trigger burn in the main fuel compressed on a low isentrope. A simple hot spot model will be described. The high pressure needed to drive the capsule compression are obtained by the ablation process. A simple Rocket model describe the main features of the implosion phase. Several parameters have to be controlled during the compression: irradiation symmetry, hydrodynamical stability and when the driver is a laser, the problems arising from interaction of the EM wave with the plasma. Two different schemes are examined: Indirect Drive which uses X-ray generated in a cavity to drive the implosion and the Fast Ignitor concept using a ultra intense laser beam to create the hot spot. At the end we present the Laser Megajoule (LMJ) project. LMJ is scaled to a thermonuclear gain of the order of ten. (authors)
Thermonuclear 36Cl pulse in natural water
International Nuclear Information System (INIS)
Bentley, H.W.; Davis, S.N.; Gifford, S.; Phillips, E.M.; Elmore, D.; Tubbs, L.E.; Gove, H.E.
1982-01-01
The enhanced concentration of 3 6Cl, produced by neutron activation of seawater and released into the environment during atmospheric thermonuclear tests in the 1950s, has been used as a tracer in natural water systems. The results of numerical modelling and analyses of water samples are presented which indicate that in the mid-latitudes the fallout peak was 3 orders of magnitude above the natural background, and that the period of enhanced 36 Cl fallout was 1953 to about 1964. The advantages of 36Cl as an environmental tracer are discussed. (U.K.)
Zone-plate coded imaging of thermonuclear burn
International Nuclear Information System (INIS)
Ceglio, N.M.
1978-01-01
The first high-resolution, direct images of the region of thermonuclear burn in laser fusion experiments have been produced using a novel, two-step imaging technique called zone-plate coded imaging. This technique is extremely versatile and well suited for the microscopy of laser fusion targets. It has a tomographic capability, which provides three-dimensional images of the source distribution. It is equally useful for imaging x-ray and particle emissions. Since this technique is much more sensitive than competing imaging techniques, it permits us to investigate low-intensity sources
Goncharov, German A.
2005-11-01
On 22 November 1955, the Semipalatinsk test site saw the test of the first domestic two-stage thermonuclear RDS-37 charge. The charge operation was based on the principle of radiation implosion. The kernel of the principle consists in the radiation generated in a primary A-bomb explosion and confined by the radiation-opaque casing propagating throughout the interior casing volume and flowing around the secondary thermonuclear unit. The secondary unit experiences a strong compression under the irradiation, with a resulting nuclear and thermonuclear explosion. The RDS-37 explosion was the strongest of all those ever realized at the Semipalatinsk test site. It produced an indelible impression on the participants in the test. This document-based paper describes the genesis of the ideas underlying the RDS-37 design and reflects the critical moments in its development. The advent of RDS-37 was an outstanding accomplishment of the scientists and engineers of our country.
Trapping of pellet cloud radiation in thermonuclear plasmas
International Nuclear Information System (INIS)
Sergeev, V.Yu.; Miroshinikov, I.V.; Sudo, Shigeru; Namba, C.; Lisitsa, V.S.
2001-01-01
The experimental and theoretical data on radiation trapping in clouds of pellets injected into thermonuclear plasmas are presented. The theoretical modeling is performed in terms of equivalent Stark spectral line widths under condition of LTE (Sakha-Boltzman) in pellet cloud plasmas. It is shown that a domain of blackbody radiation could exist in hydrogen pellet clouds resulting in ''pellet disappearance'' effect which is absent in a case of impurity pellet clouds. Reasons for this difference are discussed. (author)
International Thermonuclear Experimental Reactor
International Nuclear Information System (INIS)
Blevins, J.D.; Stasko, R.R.
1989-09-01
An international design team comprised of members from Canada, Europe, Japan, the Soviet Union, and the United States of America, are designing an experimental fusion test reactor. The engineering and testing objectives of this International Thermonuclear Experimental Reactor (ITER) are to validate the design and to demonstrate controlled ignition, extended burn of a deuterium and tritium plasma, and achieve steady state using technology expected to be available by 1990. The concept maximizes flexibility while allowing for a variety of plasma configurations and operating scenarios. During physics phase operation, the machine produces a 22 MA plasma current. In the technology phase, the machine can be reconfigured with a thicker shield and a breeding blanket to operate with an 18 MA plasma current at a major radius of 5.5 meters. Canada's involvement in the areas of safety, facility design, reactor configuration and maintenance builds on our internationally recognized design and operational expertise in developing tritium processes and CANDU related technologies
Flaw detection device for plasma facing wall in thermonuclear device
International Nuclear Information System (INIS)
Doi, Akira.
1996-01-01
The present invention concerns plasma facing walls of a thermonuclear device and provides a device for detecting a thickness of amour tiles accurately and efficiently with no manual operation. Namely, the position of the plasma facing surface of the amour tile is measured using a structure to which the amour tiles are to be disposed as a reference. Also in a case of disposing new armor tiles, the position of the plasma facing surface of the armor tiles is measured to thereby measure the wearing amount of the amour tiles based on the difference between the reference and the measured value. If a measuring means capable of measuring a plurality of amour tiles at once is used efficiency of the measurement and the detection can be enhanced. Several ten thousands of amour tiles are disposed to the plasma facing wall in a large scaled thermonuclear device, and a plenty of time was required for the detection. However, the present invention can improve the accuracy for the measurement and detection and provide time and labors-saving. (I.S.)
Energy Technology Data Exchange (ETDEWEB)
Linares, M.; Chakrabarty, D. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, Cambridge, MA 02139 (United States); Altamirano, D. [Astronomical Institute ' Anton Pannekoek' , University of Amsterdam and Center for High-Energy Astrophysics, P.O. BOX 94249, 1090 GE Amsterdam (Netherlands); Cumming, A. [Department of Physics, McGill University, 3600 Rue University, Montreal, QC H3A 2T8 (Canada); Keek, L. [School of Physics and Astronomy, University of Minnesota, 116 Church Street SE, Minneapolis, MN 55455 (United States)
2012-04-01
We present a comprehensive study of the thermonuclear bursts and millihertz quasi-periodic oscillations (mHz QPOs) from the neutron star (NS) transient and 11 Hz X-ray pulsar IGR J17480-2446, located in the globular cluster Terzan 5. The increase in burst rate that we found during its 2010 outburst, when persistent luminosity rose from 0.1 to 0.5 times the Eddington limit, is in qualitative agreement with thermonuclear burning theory yet contrary to all previous observations of thermonuclear bursts. Thermonuclear bursts gradually evolved into a mHz QPO when the accretion rate increased, and vice versa. The mHz QPOs from IGR J17480-2446 resemble those previously observed in other accreting NSs, yet they feature lower frequencies (by a factor {approx}3) and occur when the persistent luminosity is higher (by a factor 4-25). We find four distinct bursting regimes and a steep (close to inverse cubic) decrease of the burst recurrence time with increasing persistent luminosity. We compare these findings to nuclear burning models and find evidence for a transition between the pure helium and mixed hydrogen/helium ignition regimes when the persistent luminosity was about 0.3 times the Eddington limit. We also point out important discrepancies between the observed bursts and theory, which predicts brighter and less frequent bursts, and suggest that an additional source of heat in the NS envelope is required to reconcile the observed and expected burst properties. We discuss the impact of NS magnetic field and spin on the expected nuclear burning regimes, in the context of this particular pulsar.
International Nuclear Information System (INIS)
Gomberg, H.J.
1974-01-01
The invention relates to the use of the radiations resulting from thermonuclear reactions. It deals with a method comprising a combination of thermo-chemical and radiolytic reactions for treating a molecule having a high absorption rate, by the radiations of a thermonuclear reaction. This is applicable to the dissociation of water into oxygen and hydrogen [fr
Effect of excited states on thermonuclear reaction rates
International Nuclear Information System (INIS)
Sargood, D.G.
1983-01-01
Values of the ratio of the thermonuclear reaction rate of a reaction, with target nuclei in a thermal distribution of energy states, to the reaction rate with all target nuclei in their ground states are tabulated for neutron, proton and α-particle induced reactions on the naturally occurring nuclei from 20 Ne to 70 Zn, at temperatures of 1, 2, 3.5 and 5x10 9 K. The ratios are determined from reaction rates based on statistical model cross sections
International Nuclear Information System (INIS)
Linsky, J.L.
1984-01-01
The author attempts to place in context the vast amount of data obtained in the last few years as a result of X-ray, ultraviolet, optical, and microwave observations of RS CVn and similar spectroscopic binary systems. He concentrates on the RS CVn systems and their long-period analogs, and restricts the scope by attempting to answer on the basis of the recent data and theory following questions: (1) Are the original defining characteristics still valid and still adequate? (2) What is the evidence for discrete active regions? (3) Have we derived any meaningful physical properties for the atmospheres of RS CVn systems? (4) What are the flare observations telling us about magnetic fields in the RS CVn systems? (5) Is there evidence for systematic trends in RS CVn systems with spectral type?
DEFF Research Database (Denmark)
Zaretzki, J.; Bergeron, C.; Huang, T.-W.
2013-01-01
Regioselectivity-WebPredictor (RS-WebPredictor) is a server that predicts isozyme-specific cytochrome P450 (CYP)-mediated sites of metabolism (SOMs) on drug-like molecules. Predictions may be made for the promiscuous 2C9, 2D6 and 3A4 CYP isozymes, as well as CYPs 1A2, 2A6, 2B6, 2C8, 2C19 and 2E1....... RS-WebPredictor is the first freely accessible server that predicts the regioselectivity of the last six isozymes. Server execution time is fast, taking on average 2s to encode a submitted molecule and 1s to apply a given model, allowing for high-throughput use in lead optimization projects.......Availability: RS-WebPredictor is accessible for free use at http://reccr.chem.rpi.edu/ Software/RS-WebPredictor....
Controlled thermonuclear reactions and Tora Supra program
International Nuclear Information System (INIS)
1988-01-01
The research programs for the nuclear energy production by means of thermonuclear fusion are shown. TORA SUPRA, Joint European Torus, Next European Torus and those developed at the Atomic Energy Center are described. The controlled fusion necessary conditions, the energy and confinement balance, and the research of a better tokamak configuration are discussed. A description of TORA SUPRA, the ways of achieving the project and the expected delays are shown. The Controlled Fusion Research Department functions, concerning these programs, are described. The importance of international cooperation and the perspectives about the use of controlled fusion are underlined [fr
Raza, Syed Tasleem; Abbas, Shania; Siddiqi, Zeba; Mahdi, Farzana
2017-01-01
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genes polymorphism in T2DM with dyslipidemia. Totally, 559 subjects including 221 T2DM cases with dyslipidemia, 158 T2DM without dyslipidemia and 180 controls were enrolled. ACE genes polymorphism was evaluated by polymerase chain reaction (PCR), while MTHFR , FABP2 , FTO genes polymorphisms were evaluated by PCR and restriction fragment length polymorphism (RFLP). Significant association of ACE and MTHFR genes polymorphisms were found in both group of cases [T2DM with dyslipidemia (Pgenes polymorphisms were significantly associated with T2DM without dyslipidemia (P=0.038, and P= 0.019, respectively). This study concludes that ACE , FABP2 , FTO and MTHFR genes are associated with T2DM. Additionally, it also seems that ACE and MTHFR genes might be further associated with the development of dyslipidemia in T2DM cases.
Magnetic Reconnection Driven by Thermonuclear Burning
Gatto, R.; Coppi, B.
2017-10-01
Considering that fusion reaction products (e.g. α-particles) deposit their energy on the electrons, the relevant thermal energy balance equation is characterized by a fusion source term, a relatively large longitudinal thermal conductivity and an appropriate transverse thermal conductivity. Then, looking for modes that are radially localized around rational surfaces, reconnected field configurations are found that can be sustained by the electron thermal energy source due to fusion reactions. Then this process can be included in the category of endogenous reconnection processes and may be viewed as a form of the thermonuclear instability that can develop in an ignited inhomogeneous plasma. A complete analysis of the equations supporting the relevant theory is reported. Sponsored in part by the U.S. DoE.
Blanket for thermonuclear device
International Nuclear Information System (INIS)
Ozawa, Yoshihiro; Uda, Tatsuhiko; Maki, Koichi.
1993-01-01
The present invention provides a blanket of a thermonuclear device which produces tritium fuels consumed in plasmas while converting neutrons generated in the plasmas into heat energy. That is, zirconium is coated to at least one of neutron breeder pebbles and breeder pebbles, to suppress reaction between them by being in direct contact with each other at a high temperature. Further, fins are attached to a cooling pipe at a pitch smaller than the diameter of both of the pebbles, to prevent direct contact at whole surface of the pebbles and the cooling pipe, which would lower a temperature excessively. The length of the fin is controlled to control the thickness of a helium gas gap. With such constitution, direct contact of neutron breeder pebbles and the breeder pebble which are to be filled and mixed, and tend to react at a high temperature, can be prevented. The temperature of the breeding blanket is reliably prevented from lowering below a tritium emitting temperature. The structure is simplified and the production is facilitated. (I.S.)
Continuously renewed wall for a thermonuclear reactor
International Nuclear Information System (INIS)
Livshits, A.I.; Pustovojt, YU.M.; Samartsev, A.A.; Gosudarstvennyj Komitet po Ispol'zovaniyu Atomnoj Ehnergii SSSR, Moscow. Inst. Atomnoj Ehnergii)
1982-01-01
The possibility of creating a continuously renewed first wall of a thermonuclear reactor is experimentally investigated. The following variants of the wall are considered: the wall is double, its part turned to plasma is made of comparatively thin material. The external part separated from it by a small gap appears to be protected from interaction with plasma and performs structural functions. The gap contains the mixture of light helium and hydrogen and carbon-containing gas. The light gas transfers heat from internal part of the wall to the external part. Carbon-containing gas provides continuous renewal of carbon coating of the operating surface. The experiment is performed with palladium membrane 20 μm thick. Carbon is introduced into the membrane by benzol pyrolysis on one of the surfaces at the membrane temperature of 900 K. Carbon removal from the operating side of the wall due to its spraying by fast particles is modelled by chemical itching with oxygen given to the operating membrane wall. Observation of the carbon release on the operating surface is performed mass-spectrometrically according to the observation over O 2 transformation into CO and CO 2 . It is shown that in cases of benzol pressure of 5x10 -7 torr, carbon current on the opposite surface is not less than 3x10 12 atoms/sm 2 s and corresponds to the expected wall spraying rate in CF thermonuclear reactors. It is also shown that under definite conditions the formation and maintaining of a through protective carbon coating in the form of a monolayer or volumetric phase is possible
Ratcheting problems for ITER [International Thermonuclear Experimental Reactor
International Nuclear Information System (INIS)
Majumdar, S.
1991-01-01
Because of the presence of high cyclic thermal stress, pressure-induced primary stress, and disruption-induced high cyclic primary stress, ratcheting of the first wall poses a serious challenge to the designers of ITER (International Thermonuclear Experimental Reactor). Existing design tools such as the Bree diagram in the ASME Boiler and Pressure Vessels Code, are not directly applicable to ITER, because of important differences in geometry and loading modes. Available alternative models for ratcheting are discussed and new Bree diagrams, that are more relevant for fusion reactor applications, are proposed. 9 refs., 17 figs
Department of Thermonuclear Research annual report 1993
International Nuclear Information System (INIS)
Sadowski, M.; Pawlowicz, W.
1994-01-01
Department of Thermonuclear Research Annual Report 1993 presents a short review of theoretical, experimental and technological studies performed within the framework of the research program - Plasma Physics. Theoretical studies of a tokamak edge plasma, inner shell ionization by positrons, heat transfer in thin foils, and numerical simulation of HV pulse generators, are summarized. Experimental studies of X-rays and charged particles (including fusion protons) emitted from Plasma-Focus facilities, as well as measurements of plasma-ion streams generated by IONOTRON devices, are described shortly. Also presented are technological studies on data acquisition systems and material engineering, in particular the modification of solid surfaces with the plasma-ion streams. (author)
Department of Thermonuclear Research. Annual report 1988
International Nuclear Information System (INIS)
Sadowski, M.
1989-01-01
Department of Thermonuclear Research annual report 1988 presents a short review of theoretical, experimental and technological studies performed within a framework of two research programs: diagnostics of high-temperature plasma and nuclear technology. We describe theoretical investigations on the modelling of Tokamak edge plasmas, ion motions, atomic collisions, high-voltage electrode systems and plasma-focus (PF) facilities. The experimental studies on plasma-ion streams, high-current discharges of the PF-type, and on the interaction of ion beams with gaseous targets, are shortly summarized. Also presented are technological studies on electronic and high-voltage systems, as well as applications of the IONOTRON type plasma devices. (author)
Department of Thermonuclear Research annual report 1993
Energy Technology Data Exchange (ETDEWEB)
Sadowski, M; Pawlowicz, W [eds.; Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)
1994-12-31
Department of Thermonuclear Research Annual Report 1993 presents a short review of theoretical, experimental and technological studies performed within the framework of the research program - Plasma Physics. Theoretical studies of a tokamak edge plasma, inner shell ionization by positrons, heat transfer in thin foils, and numerical simulation of HV pulse generators, are summarized. Experimental studies of X-rays and charged particles (including fusion protons) emitted from Plasma-Focus facilities, as well as measurements of plasma-ion streams generated by IONOTRON devices, are described shortly. Also presented are technological studies on data acquisition systems and material engineering, in particular the modification of solid surfaces with the plasma-ion streams. (author).
Gamma-ray emission spectrum from thermonuclear fusion reactions without intrinsic broadening
DEFF Research Database (Denmark)
Nocente, M.; Källne, J.; Salewski, Mirko
2015-01-01
First principle calculations of the gamma-ray energy spectrum arising from thermonuclear reactions without intrinsic broadening in fusion plasmas are presented, extending the theoretical framework needed to interpret measurements up to the accuracy level enabled by modern high resolution instrume......First principle calculations of the gamma-ray energy spectrum arising from thermonuclear reactions without intrinsic broadening in fusion plasmas are presented, extending the theoretical framework needed to interpret measurements up to the accuracy level enabled by modern high resolution...... instruments. An analytical formula for the spectrum from Maxwellian plasmas, which extends to higher temperatures than the results previously available in the literature, has been derived and used to discuss the assumptions and limitations of earlier models. In case of radio-frequency injection, numerical...... results based on a Monte Carlo method are provided, focusing in particular on improved relations between the peak shift and width from the reaction and the temperature of protons accelerated by radio-frequency heating.The results presented in this paper significantly improve the accuracy of diagnostic...
International research co-operation in the field of controlled thermonuclear fusion
International Nuclear Information System (INIS)
2004-01-01
This 26th report by the Swiss Federal Office for Education and Science presents a review of work done in Swiss institutes in 2003 as part of international research into thermonuclear fusion. A broad outline of the project and of its significance within the wider field of thermonuclear fusion research is given. This is followed by a review of the significant events in the world of fusion research, with emphasis placed on ITER and on the EURATOM fusion programme. A further chapter summarises events in Switzerland in 2003 and the report closes with a list of contacts for more information. Three annexes provide information on the current situation in fusion research, as well as scientific and technical highlights of the work performed in 2003 at the Plasma Physics Research Centre CRPP at the Federal Institute of Technology EPFL in Lausanne, Switzerland. Annex 3 reports on results obtained at the Physics Institute of the University of Basle. The annexes are for the benefit of the technically and scientifically versed reader, and brief summaries of them are given in the main body of the report
MINBAR: A comprehensive study of 6000+ thermonuclear shell flashes from neutron stars
DEFF Research Database (Denmark)
Galloway, Duncan; in't Zand, J.J.M.; Chenevez, Jérôme
2014-01-01
Thermonuclear (type-I) X-ray bursts have been observed from accreting neutron stars since the early 1970s. These events serve as a valuable diagnostic tool to constrain the source distance; accretion rate; accreted fuel composition, and hence evolutionary status of the donor; and even the neutron...
Surface effects in controlled thermonuclear fusion
International Nuclear Information System (INIS)
Kaminsky, M.
1975-08-01
During the operation of large size plasma facilities and future controlled thermonuclear fusion reactors the surfaces of such major components as container walls, beam limiters, diverter walls and beam-dump walls of the injector region will be exposed to particle and photon bombardment from primary plasma radiations and from secondary radiations. Such radiations can cause, for example, physical and chemical sputtering, blistering, particle- and photon-impact induced desorption, secondary electron and x-ray emission, backscattering, nuclear reactions, photo-decomposition of surface compounds, photocatalysis, and vaporization. Such effects in turn can (a) seriously damage and erode the bombarded surface and (b) release major quantities of impurities which will contaminate the plasma. The effects of some of the major surface phenomena on the operation of plasma facilities and future fusion reactors are discussed
Cooling device in thermonuclear device
International Nuclear Information System (INIS)
Honda, Tsutomu.
1988-01-01
Purpose: To prevent loss of cooling effect over the entire torus structure directly after accidental toubles in a cooling device of a thermonuclear device. Constitution: Coolant recycling means of a cooling device comprises two systems, which are alternately connected with in-flow pipeways and exit pipeways of adjacent modules. The modules are cooled by way of the in-flow pipeways and the exist pipeways connected to the respective modules by means of the coolant recycling means corresponding to the respective modules. So long as one of the coolant recycling means is kept operative, since every one other modules of the torus structure is still kept cooled, the heat generated from the module put therebetween, for which the coolant recycling is interrupted, is removed by means of heat conduction or radiation from the module for which the cooling is kept continued. No back-up emergency cooling system is required and it can provide high economic reliability. (Kamimura, M.)
First wall of thermonuclear device
International Nuclear Information System (INIS)
Miki, Nobuharu.
1992-01-01
In a first wall of a thermonuclear device, armour tiles are metallurgically bonded to a support substrate only for the narrow area of the central portion thereof, while bonded by metallurgical bonding with cooling tubes of low mechanical toughness, separated from each other in other regions. Since the bonding area with the support substrate of great mechanical rigidity is limited to the narrow region at the central portion of the armour tiles, cracking are scarcely caused at the end portion of the bonding surface. In other regions, since cooling tubes of low mechanical rigidity are bonded metallurgically, they can be sufficiently withstand to high thermal load. That is, even if the armour tiles are deformed while undergoing thermal load from plasmas, since the cooling tubes absorb it, there is no worry of damaging the metallurgically bonded face. Since the cooling tubes are bonded directly to the armour tiles, they absorb the heat of the armour tiles efficiently. (N.H.)
Transition to thermonuclear burn in fusion plasmas
International Nuclear Information System (INIS)
Anderson, D.; Hamnen, H.; Lisak, M.
1991-01-01
An analytical investigation is made of the time evolution of the 1-D temperature profile in a fusion reactor plasma where the nonlinear energy balance equation is dominated by alpha-particle heating and thermal conduction losses. Special emphasis is given to the problem of establishing sufficient conditions for the transition to thermonuclear burn for given initial temperature profiles. In particular, it is demonstrated that for strongly nonlinear alpha-particle heating, temperature profiles initially peaked on-axis are more easily ignited than profiles similar in form to the equilibrium profile of the energy balance equation. Simple analytical criteria for ignition are established and are shown to compare favourably with results of numerical calculations. (author)
Puzzling thermonuclear burst behaviour from the transient low-mass X-ray binary IGR J17473-2721
DEFF Research Database (Denmark)
Chenevez, Jérôme
2010-01-01
We investigate the thermonuclear bursting behaviour of IGR J17473-2721, an X-ray transient that in 2008 underwent a six month long outburst, starting (unusually) with an X-ray burst. We detected a total of 57 thermonuclear bursts throughout the outburst with AGILE, Swift, RXTE, and INTEGRAL...... it dropped (at a persistent flux corresponding to 15%of m˙ Edd) a few days before the outburst peak, after which bursts were not detected for a month. As the persistent emission subsequently decreased, the bursting activity resumed at a much lower rate than during the outburst rise. This hysteresis may arise...... produced a similar quenching of burst activity....
The role of materials in controlled thermonuclear research
Energy Technology Data Exchange (ETDEWEB)
Craston, J L; Hancox, R; Robson, A E [U.K. Atomic Energy Authority, AERE, Harwell (United Kingdom); Kaufman, S; Miles, H T; Ware, A A; Wesson, J A [AEI Research Laboratory, Aldermaston (United Kingdom)
1958-07-01
It is the purpose of this paper to examine the processes occurring at the wall and to discuss their importance in the choice of materials both for present equipment and for future designs. The emphasis is laid primarily on plasma contamination but other effects are considered, such as thermal stress fatigue and radiation damage of the wall. The principal problems associated with the choice of wall material for a high current discharge tube have been discussed, both under the conditions which exist in present systems and under the conditions which are anticipated in a thermonuclear reactor.
Thermonuclear reaction rates in a deuterium-tritium plasma
International Nuclear Information System (INIS)
Beckman, L.
1978-12-01
In a deuterium-tritium plasma six thermonuclear reactions take place between the deuterons, tritons and the 3 He-particles formed in about half of the d-d-reactions. The rate constants for these six reactions have been calculated from the latest evaluations of the reaction cross sections which were available. In some cases, notably the reactions t+t, t+ 3 He and 3 He+ 3 He, the number of published cross section measurements is small, and the uncertainty in the calculated rate constants consequently large. Analytical expressions for the rate constants as functions of the plasma temperature have been set up. (author)
Controlled thermonuclear fusion and the latest progress on China's HT-7 superconducting tokamak
International Nuclear Information System (INIS)
Li Jiangang; Yang Yu
2003-01-01
After 50 years of research on controlled thermonuclear fusion, a new stage will be reached in 2003, when a site for the International Thermonuclear Experimental Reactor project will be chosen to start the construction. Scientists hope that this project could herald a new era in which the energy problem will be solved completely. The great progress made on the HT-7 superconducting tokamak in China has provided positive and powerful support for fusion research. The HT-7 is one of the only two superconducting tokamaks in the world that can carry out minute-scale high temperature plasma research, and has achieved a duration of 63.95s for the hot plasma discharge. This is a major step towards real steady-state operation of the tokamak configuration. We present an overview of the latest progress on the tokamak experiments in the Institute of Plasma Physics, Chinese Academy of Sciences
Status report on controlled thermonuclear fusion
International Nuclear Information System (INIS)
1990-01-01
The International Fusion Research Council has prepared this report on the current status of fusion, an update of its 1978 report, at the request of the Director General of the International Atomic Energy Agency. The report consists of an introductory note by the Director General, an Executive Summary and General Overview published in this document, and a series of technical reports. The background of fusion as an energy source is documented and compared with fission. The two approaches to thermonuclear fusion, magnetic confinement and inertial confinement, are discussed. The viability with respect to economic, environmental, and safety aspects is discussed. Fusion programs in the European Community, Japan, the USSR, the USA, as well as smaller programs in other countries are described. The status of fusion physics and technology is elucidated, and future directions and plans are indicated. 5 refs, 6 figs
International Nuclear Information System (INIS)
Leng, Wei-Dong; Wen, Xiu-Jie; Kwong, Joey S. W.; Huang, Wei; Chen, Jian-Gang; Zeng, Xian-Tao
2016-01-01
Numerous case–control studies have been performed to investigate the association between three cyclooxygenase-2 (COX-2) polymorphisms (rs20417 (−765G > C), rs689466 (−1195G > A), and rs5275 (8473 T > C)) and the risk of head and neck squamous cell carcinoma (HNSCC). However, the results were inconsistent. Therefore, we conducted this meta-analysis to investigate the association. We searched in PubMed, Embase, and Web of Science up to January 20, 2015 (last updated on May 12, 2016). Two independent reviewers extracted the data. Odds ratios (ORs) with their 95 % confidence intervals (CIs) were used to assess the association. All statistical analyses were performed using the Review Manager (RevMan) 5.2 software. Finally 8 case–control studies were included in this meta-analysis. For unadjusted data, an association with increased risk was observed in three genetic models in COX-2 rs689466 polymorphism; however, COX-2 rs5275 and rs20417 polymorphisms were not related to HNSCC risk in this study. The pooled results from adjusted data all revealed non-significant association between these three polymorphisms and risk of HNSCC. We also found a similar result in the subgroup analyses, based on both unadjusted data and adjusted data. Current results suggest that COX-2 rs689466, rs5275, and rs20417 polymorphisms are not associated with HNSCC. Further large and well-designed studies are necessary to validate this association
Probing thermonuclear burning on accreting neutron stars
Keek, L.
2008-12-01
Neutron stars are the most compact stars that can be directly observed, which makes them ideal laboratories to study physics at extreme densities. Neutron stars in low-mass X-ray binaries accrete hydrogen and helium from a lower-mass companion star through Roche lobe overflow. This matter undergoes thermonuclear burning in the neutron star envelope, creating carbon and heavier elements. The fusion process may proceed in an unstable manner, resulting in a thermonuclear runaway. Within one second the entire surface is burned, which is observable as a sharp rise in the emitted X-ray flux: a type I X-ray burst. Afterwards the neutron star surface cools down on a timescale of ten to one hundred seconds. During these bursts the surface of an accreting neutron star can be observed directly, which makes them instrumental for studying this type of stars. We have studied rare kinds of X-ray bursts. One such rare burst is the superburst, which lasts a thousand times longer than an ordinary burst. Superbursts are thought to result from the explosive burning of a thick carbon layer, which lies deeper inside the neutron star, close to a layer known as the crust. A prerequisite for the occurrence of a superburst is a high enough temperature, which is set by the temperature of the crust and the heat conductivity of the envelope. The latter is lowered by the presence of heavy elements that are produced during normal X-ray bursts. Using a large set of observations from the Wide Field Camera's onboard the BeppoSAX satellite, we find that, at high accretion rate, sources which do not exhibit normal bursts likely have a longer superburst recurrence time, than the observed superburst recurrence time of one burster. We analyze in detail the first superburst from a transient source, which went into outburst only 55 days before the superburst. Recent models of the neutron star crust predict that this is too small a time to heat the crust sufficiently for superburst ignition, indicating
Thermonuclear-driven fast magnetosonic-wave heating in tokamak plasmas
International Nuclear Information System (INIS)
Sutton, W.R. III.
1982-01-01
A thermonuclear driven fast magnetosonic wave instability is investigated in tokamak plasmas for propagation transverse to the external magnetic field at frequencies of several times the alpha particle gyro rate: ω approx. = L Ω/sub α/ = k/sub perpendicular/ v/sub A/, L approx. 4 to 8, k/sub parallel/ << k/sub perpendicular/. The 2-D differential quasi-linear diffusion equation is derived in circular cylindrical, v/sub perpendicular/-v/sub parallel/ geometry. We perform an expansion in the small parameter k/sub parallel/k/sub perpendicucular/ of the quasi-linear diffusion coefficients
Role of thermonuclear instability in recent models of nova stars
Energy Technology Data Exchange (ETDEWEB)
Secco, L [Padua Univ. (Italy). Ist. di Astronomia
1981-10-11
In this paper we review models of nova-star explosion based on the original suggestion by Kraft and developed during about ten years (from 1967). We aim at summarizing here the most salient results of those theoretical models and to point out the many aspects of the problems that are still unsettled. In particular, we analyse thermonuclear instabilities both in perfect and electron-degenerate gas, since they seem to be at the base of the nova explosion phenomena.
Directory of Open Access Journals (Sweden)
Juan YI
2016-10-01
Full Text Available Objective To investigate the relations of Fetuin-A gene rs1071592 and rs2593813 single nucleotide polymorphisms (SNPs with the affect ability to polycystic ovary syndrome (PCOS and its endocrine and metabolic characteristics in Chongqing Han population. Methods A case-control study was performed in Chinese Han subjects. The clinical data of 156 cases of normal control and 147 cases of PCOS patients were collected, and their blood glucose, lipids, sex hormone and other biochemical indexes were determined, the SNPs of rs1071592 and rs2593813 were genotyped by TaqMan SNP Genotyping Assay. Hyperinsulinemic-euglycemic clamp was performed in 147 PCOS women and 20 controls. The relative risk of developing PCOS in women with rs1071592 genotype was assessed using a binary logistic regression analysis. Results The distribution frequency of Fetuin-A gene homozygous rs1071592 AA genotype and A allele was significantly increased in PCOS patients than in controls (Pc0.05. Binary logistic regression analysis showed that the risk of developing PCOS was 4.93 times high in women with AA genotype of rs1071592 (OR=4.933, 95%CI 1.593-15.278, P0.05. Conclusion People with SNPs variants of rs1071592 in Fetuin-A gene may have an increased genetic susceptibility to PCOS. However, there won't be significant relationship between SNP of rs2593813 at Fetuin-A gene and PCOS. DOI: 10.11855/j.issn.0577-7402.2016.09.07
Nuclear Physics Constraints on the Characteristics of Astrophysical Thermonuclear Flashes
International Nuclear Information System (INIS)
Truran, James W
2012-01-01
We review the nuclear physics that is associated with the outbursts of Type Ia (thermonuclear) supernova explosions and with the thermonuclear runaway events that define the outbursts of both classical novae and recurrent novae. We describe how distinguishing characteristics of these two classes of astrophysical explosion are strongly dependent both upon fuel ignition in degenerate matter and upon the rates of critical charged-particle reaction rates and weak interaction rates. In this centennial celebration of the important contributions of Rutherford and his collaborators to our understanding of the structure of the nucleus of an atom, it is quite interesting to note the evolution of the α-particle scattering experiments described in Rutherford's seminal paper (Rutherford 1911) to current studies of α-particle induced reactions and their defining roles in studies of stellar, nova, and supernova nucleosynthesis. We identify and discuss for example: (1) the manner in which (α, p) reactions in proximity to the Z = N line carry the major flows from 12 C and 16 O to 56 Ni in Type Ia supernovae; and (2) the critical role of the 15 O(α, γ) 19 Ne reaction in possibly effecting 'breakout' of the Hot CNO cycles at the highest temperatures achievable in Classical Novae. In this contribution, we first review the current status our understanding of Type Ia supernova events and then that of Classical Novae.
Baking method for thermonuclear reactor
International Nuclear Information System (INIS)
Kobayashi, Shigetada.
1986-01-01
Purpose: To improve the heat transmission property to the reactor core structures thereby shortening the baking time for the reactor core in thermonuclear reactors. Constitution: High temperature airs are supplied from a baking system to cooling pipeways disposed within reactor core structures and helium gas is supplied from a helium gas supply system through the reactor core structures to the inside of the reactor core for scavenging. The scavenging operation may be combined with vacuum suction. Further, the inside of the reactor is scavenged while maintaining at such a negative pressure as within a range not degrading the heat conduction property. Since the helium gas is chemically inert and poor in the depositing property, it shows no adsorbability even for the material heated to high temperature. Further, since the diffusion and heat conduction properties are high, the heat conduction property to the materials upon baking can be improved to shorten the baking time. No disadvantages are caused by the introduction of the helium gas upon baking. (Kawakami, Y.)
International Nuclear Information System (INIS)
Linsky, J.L.
1984-01-01
An attempt is made to place in context the vast amount of data obtained as a result of X-ray, ultraviolet, optical, and microwave observations of RS CVn and similar spectroscopic binary systems. Emphasis is on the RS CVn systems and their long period analogs. The following questions are considered: (1) are the original defining characteristics still valid and still adequate; (2) what is the evidence for discrete active regions; (3) have any meaningful physical properties for the atmospheres of RS CVn systems been derived; (4) what do the flare observations tell about magnetic fields in RS CVn systems; (5) is there evidence for systematic trends in RS CVn systems with spectral type
Vacuum problems of thermonuclear reactor design
International Nuclear Information System (INIS)
Paty, L.
1981-01-01
A thermonuclear reactor can be considered to be a vacuum system in which constant concentration should be maintained of reacting particles while permanently discharging the undesirable particles using a system of pumps. The discharging proceeds in two stages: in the former, the reactor is degassed using external pumps connected to the reactor chamber through a pumping pipe. The latter in which hydrogen is admitted, uses high pump-rate machines based on the principle of the binding of the gas to the pump surface and must not introduce molecules of higher atomic mass in the system. Turbomolecular pumps of diffusion oil pumps are most suitable for the former stage while condensation, cryosorption, titanium pumping machines and special pumping methods are most suitable for the latter stage. Examples are shown of the pump system design for Tokamak 10 and for facilities at the Euratom laboratory in Fontenay-aux-Roses. (M.D.)
Baking exhaustion device in thermonuclear device
Energy Technology Data Exchange (ETDEWEB)
Kondo, Mitsunori.
1987-02-02
Purpose: To rapidly remove tritium and impurity from the vacuum region in the access port of the baking exhaustion device in a thermonuclear device. Constitution: Each of the gaps at the boundary between a fixed shielding member and a blanket module and at the boundary between the blanket and a divertor is made extremely small so as to minimize the neutron streaming from plasmas. Accordingly, in the case of evacuating the vacuum region in the access port, the gap conductance is extremely poor and the exhaustion speed is low. Then, baking pipeways for flowing high temperature fluids are embedded to the surface layer at the position facing to the vacuum region and the plasma evacuation duct and the vacuum region are connected with an evacuation duct of the access port. By flowing high temperature fluids in the pipeways and conducting evacuation, baking exhaustion can be carried out rapidly. (Kamimura, M.).
Role of thermonuclear instabilities of recent models of nova-stars
Energy Technology Data Exchange (ETDEWEB)
Secco, L [Padua Univ. (Italy). Ist. di Astronomia
1981-10-11
In this paper, a review models of nova-star explosion based on the original suggestion by Kraft and developed during about ten years (from 1967) is presented. The aim is to summarize the most salient results of those theoretical models and to point out the many aspects of the problems that are still unsettled. In particular, thermonuclear instabilities both in perfect and electron-degenerate gas are analyzed, since they seem to be at the base of the nova explosion phenomena.
Energy Technology Data Exchange (ETDEWEB)
Garin, P [CEA Cadarache, Dept. de Recherches sur la Fusion Controlee - DRFC, 13 - Saint-Paul-lez-Durance (France)
2003-01-01
This document gathers the slides of the 6 contributions to the workshop 'the physics of thermo-nuclear fusion and the ITER project': 1) the feasibility of magnetic confinement and the issue of heat recovery, 2) heating and current generation in tokamaks, 3) the physics of wall-plasma interaction, 4) recent results at JET, 5) inertial confinement and fast ignition, and 6) the technology of fusion machines based on magnetic confinement. This document presents the principles of thermo-nuclear fusion machines and gives a lot of technical information about JET, Tore-Supra and ITER.
2010-07-01
... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae 742RS; exemptions from the requirement of a tolerance... Tolerances § 180.1114 Pseudomonas fluorescens A506, Pseudomonas fluorescens 1629RS, and Pseudomonas syringae...
Thermonuclear reactor materials composed of glassy carbons
International Nuclear Information System (INIS)
Kazumata, Yukio.
1979-01-01
Purpose: To improve the durability to plasma radiation by the use of glassy carbon as the structural materials for the first wall and the blanket in thermonuclear devices. Constitution: The glassy carbon (glass-like carbon) is obtained by forming specific organic substances into a predetermined configuration and carbonizing them by heat decomposition under special conditions. They are impermeable carbon material of 1.40 - 1.70 specific gravity, less graphitizable and being almost in isotropic crystal forms in which isotropic structure such as in graphite is scarcely observed. They have an extremely high hardness, are less likely to be damaged when exposed to radiation and have great strength and corrosion resistance. Accordingly, the service life of the reactor walls and the likes can remarkably be increased by using the materials. (Horiuchi, T.)
Integration of element technology and system supporting thermonuclear fusion
International Nuclear Information System (INIS)
2003-01-01
A special committee for integrated system technology survey on thermonuclear fusion (TNF) was begun on June, 1999, under an aim to generally summarize whole of shapes on technology to realize TNF reactor to summarize present state of every technologies and their positioning in whole of their TNF technology. On a base of survey of these recent informations, this report is comprehensively summarized for an integrated system technology on TNF. It has outlines on magnetic field enclosing method, outlines on inertia enclosing method, element technology supporting TNF, new power generation techniques, and ripple effects on TNF technology. (G.K.)
Approximating the r-process on earth with thermonuclear explosions
International Nuclear Information System (INIS)
Becker, S.A.
1992-01-01
The astrophysical r-process can be approximately simulated in certain types of thermonuclear explosions. Between 1952 and 1969 twenty-three nuclear tests were fielded by the United States which had as one of their objectives the production of heavy transuranic elements. Of these tests, fifteen were at least partially successful. Some of these shots were conducted under the project Plowshare Peaceful Nuclear Explosion Program as scientific research experiments. A review of the program, target nuclei used, and heavy element yields achieved, will be presented as well as discussion of plans for a new experiment in a future nuclear test
Evidence for a link between atmospheric thermonuclear detonations and nitric acid
International Nuclear Information System (INIS)
Holdsworth, G.
1986-01-01
Data are presented for an ice core, which show that during the era of intense atmospheric thermonuclear weapons testing, a significant part of the nitrate content in the snow was modulated by the intensity of the nuclear detonations. The fixation of nitrogen by nuclear fireballs leads to NOsub(x) gases in the atmosphere and ultimately to nitric acid in precipitation. At certain concentrations, these gases and the associated aerosols may perturb the climate. (author)
International Nuclear Information System (INIS)
Winterberg, F.
1982-01-01
A proposal for the fissionless ignition of small thermonuclear reactions is made which involves the combination of the magnetic booster target inertial fusion concept with the chemical implosion of metallic shells. The magnetic booster employs a very dense and magnetically confined low yield thermonuclear plasma to trigger an inertially confined high yield plasma. Fissionless ignition permits smaller yields than with fission- or fusion-induced fusion bombs, yields that are appropriate for use in a spacecraft propulsion system. Each bomb would release about 10 to the 18th erg or 100 tons of TNT, and with one explosion per second, an average thrust of 10 to the third tons and a specific impulse of about 3000 seconds can be expected
First fusion neutrons from a thermonuclear weapon device
International Nuclear Information System (INIS)
Anon.
1976-01-01
An account of the first observation of thermonuclear neutrons from a hydrogen weapon, the George shot, is presented. A personal narrative by the researchers J. Allred and L. Rosen includes such topics as the formation of the experimental team, description of the experimental technique, testing the experimental apparatus, testing the effects of a blast, a description of the test area, and the observation of neutrons from fusion. Excerpts are presented from several chapters of the Scientific Director's report on the atomic weapons tests of 1951. Also included is a brief description of the basic design of the hydrogen bomb, a recounting of subsequent developments, and short scientific biographies of the researchers. 21 figures, 2 tables
International Nuclear Information System (INIS)
Basov, N.G.; Danilov, A.E.; Krokhin, O.N.; Kruglov, B.V.; Mikhailov, Yu.A.; Sklizkov, G.V.; Fedotov, S.I.; Fedorov, A.N.
This paper describes a high-energy, twelve-channel laser facility (DELFIN) intended for high-temperature heating of thermonuclear targets with spherical symmetry. The facility includes a neodymium-glass laser with the ultimate radiation energy of 10 kJ, a pulse length of approximately 10 -10 to 10 -9 s, beam divergence of 5 x 10 -4 radians, a vacuum chamber in which laser radiation interacts with the plasma, and a system of diagnostic instrumentation for the observation of laser beam and plasma parameters. Described are the optical scheme and construction details of the laser facility. Presented is an analysis of focusing schemes for target irradiation and described is the focusing scheme of the DELFIN facility, which is capable of attaining a high degree of spherical symmetry in irradiating targets with maximum beam intensity at the target surface of approximately 10 15 W/cm 2 . This paper examines the most important problems connected with the physical investigations of thermonuclear laser plasma and the basic diagnostic problems involved in their solution
Energy Technology Data Exchange (ETDEWEB)
Poteet, Charles A.; Whittet, Douglas C. B. [New York Center for Astrobiology, Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180 (United States); Draine, Bruce T., E-mail: charles.poteet@gmail.com [Princeton University Observatory, Peyton Hall, Princeton, NJ 08544 (United States)
2015-03-10
We investigate the composition of interstellar grains along the line of sight toward ζ Ophiuchi, a well-studied environment near the diffuse-dense cloud transition. A spectral decomposition analysis of the solid-state absorbers is performed using archival spectroscopic observations from the Spitzer Space Telescope and Infrared Space Observatory. We find strong evidence for the presence of sub-micron-sized amorphous silicate grains, principally comprised of olivine-like composition, with no convincing evidence of H{sub 2}O ice mantles. However, tentative evidence for thick H{sub 2}O ice mantles on large (a ≈ 2.8 μm) grains is presented. Solid-state abundances of elemental Mg, Si, Fe, and O are inferred from our analysis and compared to standard reference abundances. We find that nearly all of the Mg and Si atoms along the line of sight reside in amorphous silicate grains, while a substantial fraction of the elemental Fe resides in compounds other than silicates. Moreover, we find that the total abundance of elemental O is largely inconsistent with the adopted reference abundances, indicating that as much as ∼156 ppm of interstellar O is missing along the line of sight. After taking into account additional limits on the abundance of elemental O in other O-bearing solids, we conclude that any missing reservoir of elemental O must reside on large grains that are nearly opaque to infrared radiation.
Protection device for a thermonuclear device
International Nuclear Information System (INIS)
Kawashima, Shuichi.
1986-01-01
Purpose: To exactly detect the void coefficients of coolants even under high magnetic fields thereby detect the overheat of a thermonuclear device at an early stage. Constitution: The protecting device of this invention comprises a laser beam generation device, a laser beam detection device and an accident detection device. The laser generation device always generates laser beams, which are permeated through coolants and detected by the laser beam detection device, the optical amount of which is transmitted to the accident detection device. The accident detection device judges the excess or insufficiency of the detected optical amount with respect to the optical amount of the laser beams under the stationary state as a reference and issues an accident signal. Since only the optical cables that do not undergo the effect of the magnetic fields are exposed to high magnetic fields in the protection device of this invention, a high reliability can be maintained. (Kamimura, M.)
Bilski, P; D'Errico, F; Esposito, A; Fehrenbacher, G; Fernàndez, F; Fuchs, A; Golnik, N; Lacoste, V; Leuschner, A; Sandri, S; Silari, M; Spurny, F; Wiegel, B; Wright, P
2006-01-01
This report outlines the research needs and research activities within Europe to develop new and improved methods and techniques for the characterization of complex radiation fields at workplaces around high-energy accelerators and the next generation of thermonuclear fusion facilities under the auspices of the COordinated Network for RAdiation Dosimetry (CONRAD) project funded by the European Commission.
Transient temperature variations during the self-heating of a plasma by thermonuclear reactions
Energy Technology Data Exchange (ETDEWEB)
Greyber, Howard D [University of California Radiation Laboratory, Livermore, CA (United States)
1958-07-01
The motivation for this work arose from an observation by Rosenbluth that in a different but related physical situation, the electron temperature) could exceed ion temperature, during transient heating. We have undertaken to trace the transient temperatures to be expected in an idealized physical situation that still bears some resemblance to what one envisions for the Controlled Thermonuclear Reactor.
THE FERMI-GBM X-RAY BURST MONITOR: THERMONUCLEAR BURSTS FROM 4U 0614+09
International Nuclear Information System (INIS)
Linares, M.; Chakrabarty, D.; Connaughton, V.; Bhat, P. N.; Briggs, M. S.; Preece, R.; Jenke, P.; Kouveliotou, C.; Wilson-Hodge, C. A.; Van der Horst, A. J.; Camero-Arranz, A.; Finger, M.; Paciesas, W. S.; Beklen, E.; Von Kienlin, A.
2012-01-01
Thermonuclear bursts from slowly accreting neutron stars (NSs) have proven difficult to detect, yet they are potential probes of the thermal properties of the NS interior. During the first year of a systematic all-sky search for X-ray bursts using the Gamma-ray Burst Monitor aboard the Fermi Gamma-ray Space Telescope we have detected 15 thermonuclear bursts from the NS low-mass X-ray binary 4U 0614+09 when it was accreting at nearly 1% of the Eddington limit. We measured an average burst recurrence time of 12 ± 3 days (68% confidence interval) between 2010 March and 2011 March, classified all bursts as normal duration bursts and placed a lower limit on the recurrence time of long/intermediate bursts of 62 days (95% confidence level). We discuss how observations of thermonuclear bursts in the hard X-ray band compare to pointed soft X-ray observations and quantify such bandpass effects on measurements of burst radiated energy and duration. We put our results for 4U 0614+09 in the context of other bursters and briefly discuss the constraints on ignition models. Interestingly, we find that the burst energies in 4U 0614+09 are on average between those of normal duration bursts and those measured in long/intermediate bursts. Such a continuous distribution in burst energy provides a new observational link between normal and long/intermediate bursts. We suggest that the apparent bimodal distribution that defined normal and long/intermediate duration bursts during the last decade could be due to an observational bias toward detecting only the longest and most energetic bursts from slowly accreting NSs.
International Nuclear Information System (INIS)
Barnett, C.F.
1976-01-01
The U.S. role in the compilation and evaluation of atomic data for controlled thermonuclear research is discussed in the following three areas: (1) atomic structure data, (2) atomic collision data, and (3) surface data
DEFF Research Database (Denmark)
Leipold, Frank; Furtula, Vedran; Salewski, Mirko
2009-01-01
Fast ion physics will play an important role for the international thermonuclear experimental reactor (ITER), where confined alpha particles will affect and be affected by plasma dynamics and thereby have impacts on the overall confinement. A fast ion collective Thomson scattering (CTS) diagnostic...
Department of Thermonuclear Research annual report 1990
Energy Technology Data Exchange (ETDEWEB)
Sadowski, M [ed.
1991-03-01
Department of Thermonuclear Research Annual Report 1990 presents the most important results of theoretical, experimental, and technological studies, carried out within a framework of two programs: Diagnostics of High-Temperature Plasma (CPBP 01.10) and Nuclear Technology (CPBR 5.8). Theoretical studies of tokamak edge plasmas, charged particle motions, strong refraction effects, current pulse generators, classical models of atomic collisions, and electron mechanisms of the Coulomb barrier tunneling, are shortly summarized. Experimental studies of X-ray, ion, and proton emission from the RPI-type devices, as well as optimization tests and electron beam measurements at the PF-type facilities, are described. Technological studies of opto-electronic transmission systems, modifications of diagnostic equipment, design and construction of new PF facilities, as well as applications of the IONOTRON-type devices, are also presented. (author). 56 refs, 20 figs.
Department of Thermonuclear Research annual report 1991
Energy Technology Data Exchange (ETDEWEB)
Sadowski, M; Pawlowicz, W [eds.
1992-02-01
Department of Thermonuclear Research Annual Report 1991 presents a short review of theoretical, experimental, and technological studies carried out within the framework of two research programs: Plasma Physics and Development of Diagnostics Data Acquisition. Theoretical studies of a tokamak edge plasma, validity of inverse Abel transformation for strongly refracting objects, simulation of the pulse generators operation, and a numerical analysis of electron capture in p + H{sup +} collisions, are described. Experimental studies of corpuscular beams and X-rays from different plasma facilities, development of diagnostic techniques and of data acquisition systems, as well as experiments with the generation of cryogenic pellets for plasma research, are shortly summarized. Also presented are technological studies concerning the modernization of the PF- and RPI-type facilities and the application of the IONOTRON-type devices for the modification of semiconductor and metal surfaces. (author). 27 refs, 24 figs.
Department of Thermonuclear Research annual report 1990
International Nuclear Information System (INIS)
Sadowski, M.
1991-03-01
Department of Thermonuclear Research Annual Report 1990 presents the most important results of theoretical, experimental, and technological studies, carried out within a framework of two programs: Diagnostics of High-Temperature Plasma (CPBP 01.10) and Nuclear Technology (CPBR 5.8). Theoretical studies of tokamak edge plasmas, charged particle motions, strong refraction effects, current pulse generators, classical models of atomic collisions, and electron mechanisms of the Coulomb barrier tunneling, are shortly summarized. Experimental studies of X-ray, ion, and proton emission from the RPI-type devices, as well as optimization tests and electron beam measurements at the PF-type facilities, are described. Technological studies of opto-electronic transmission systems, modifications of diagnostic equipment, design and construction of new PF facilities, as well as applications of the IONOTRON-type devices, are also presented. (author). 56 refs, 20 figs
Department of Thermonuclear Research annual report 1991
International Nuclear Information System (INIS)
Sadowski, M.; Pawlowicz, W.
1992-02-01
Department of Thermonuclear Research Annual Report 1991 presents a short review of theoretical, experimental, and technological studies carried out within the framework of two research programs: Plasma Physics and Development of Diagnostics Data Acquisition. Theoretical studies of a tokamak edge plasma, validity of inverse Abel transformation for strongly refracting objects, simulation of the pulse generators operation, and a numerical analysis of electron capture in p + H + collisions, are described. Experimental studies of corpuscular beams and X-rays from different plasma facilities, development of diagnostic techniques and of data acquisition systems, as well as experiments with the generation of cryogenic pellets for plasma research, are shortly summarized. Also presented are technological studies concerning the modernization of the PF- and RPI-type facilities and the application of the IONOTRON-type devices for the modification of semiconductor and metal surfaces. (author). 27 refs, 24 figs
Shielding wall for thermonuclear device
International Nuclear Information System (INIS)
Uchida, Takaho.
1989-01-01
This invention concerns shielding walls opposing to plasmas of a thermonuclear device and it is an object thereof to conduct reactor operation with no troubles even if a portion of shielding wall tiles should be damaged. That is, the shielding wall tiles are constituted as a dual layer structure in which the lower base tiles are connected by means of bolts to first walls. Further, the upper surface tiles are bolt-connected to the layer base tiles. In this structure, the plasma thermal loads are directly received by the surface layer tiles and heat is conducted by means of conduction and radiation to the underlying base tiles and the first walls. Even upon occurrence of destruction accidents to the surface layer tiles caused by incident heat or electromagnetic force upon elimination of plasmas, since the underlying base tiles remain as they are, the first walls constituted with stainless steels, etc. are not directly exposed to the plasmas. Accordingly, the integrity of the first walls having cooling channels can be maintained and sputtering intrusion of atoms of high atom number into the plasmas can be prevented. (I.S.)
Shielding member for thermonuclear device
Energy Technology Data Exchange (ETDEWEB)
Onozuka, Masanori
1997-06-30
In a thermonuclear device for shielding fast neutrons by shielding members disposed in a shielding vessel (vacuum vessel and structures such as a blanket disposed in the vacuum vessel), the shielding member comprises a large number of shielding wires formed fine and short so as to have elasticity. The shielding wires are sealed in a shielding vessel together with water, and when the width of the shielding vessel is changed, the shielding wires follow after the change of the width while elastically deforming in the shielding vessel, so that great stress and deformation are not formed thereby enabling to improve reliability. In addition, the length, the diameter and the shape of each of the shielding wires can be selected in accordance with the shielding space of the shielding vessel. Even if the shape of the shielding vessel is complicated, the shielding wires can be inserted easily. Accordingly, the filling rate of the shielding members can be changed easily. It can be produced more easily compared with a conventional spherical pebbles. It can be produced more easily than existent spherical shielding pebbles thereby enabling to reduce the production cost. (N.H.)
Divertor plate for thermonuclear reactor
International Nuclear Information System (INIS)
Yamazaki, Seiichiro; Sato, Keisuke; Nishio, Satoshi.
1993-01-01
In a divertor plate for a thermonuclear reactor, adjacent cooling pipes are electrically insulated from each other and pipes made of a gradient functional material prepared by compositing ceramics having an insulation property and metals are metallurgically joined to at least one portion of each of the cooling pipes. Electric current caused upon occurrence of plasma disruption is interrupted by the insulation portion, so that a large circuit is not formed and electromagnetic force is decreased to such a extent that the divertor plate is not ruptured. Since a header of the cooling pipes can be installed at any optional position, the installation space can be reduced. Further, since inlet and exit collection headers can be disposed on both ends of the cooling pipes, it is possible to shorten the length of the cooling pipe of the divertor plate corresponded to high heat fluxes and reduce the pressure loss on the side of coolants to about 1/2. Further, turn back portions of small radius of curvature of the cooling pipes are eliminated to reduce the cost and extend the lifetime and, in addition, protection tiles can be attached easily. (N.H.)
First wall for thermonuclear device
International Nuclear Information System (INIS)
Shibuya, Yoji.
1988-01-01
Purpose: To reduce the thermal stresses resulted to tiles and suppress the temperature rise for mounting jigs in first walls for a thermonuclear device. Constitution: A support mounting rod as a tile mounting and fixing jig and a fixing support connected therewith are disposed to the inside of an armour tile composed of high melting material and, further, a spring is disposed between the lower portion of the tile and the base plate. The armour tile can easily be fixed to the base plate by means of the resilient member by rotating the support member and abutting the support member against the support member abutting portion of the base plate. Further, since the contact and fixing surface of the armour tile and the fixing jig is situated below the tile inside the cooled base plate, the temperature rise can be suppressed as compared with the usual case. Since screw or like other clamping portion is not used for fixing the tile, heat resistant ceramics can be used with no restriction only to metal members, to thereby moderate the restriction in view of the temperature. (Kamimura, M.)
International Nuclear Information System (INIS)
Paris, P.J.; Yassen, F.; Assis, A.S. de; Raposo, C.
1988-07-01
The development of controlled thermonuclear reaction in TOKAMAK type reactors, and the main projects in the world are presented. The main characteristics of the JET (Joint European Torus) program, the perspectives for energy production, and the international cooperation for viable use of the TOKAMAK are analysed. (M.C.K.) [pt
International Nuclear Information System (INIS)
The thermonuclear fusion is in an early development state and has however in principle possible advantages which could be especially valuable for Europe. The primary fusion fuels (D, Li) are plentiful existent, wide spread and cheap (1 g natural Lithium could generate 15 MHW); both fuels and the end product of the reactions - Helium - are stable. From the nuclear-technological point of view a thermonuclear reactor could be built with high safety; the doubling time for breeding of new fuels in principle could be very short. These potential advantages however are balanced by certain disadvantages, e.g. high costs for the construction of a thermonuclear reactor etc. The research program, other possibilities and the costs are outlined. (orig./HT) [de
Fodil, M; Benzaoui, A; Zemani-Fodil, F; Aberkane, M; Boughrara, W; Saidi-Mehtar, N; Petit-Teixeira, E; Boudjema, A
2015-01-01
The aim of the present study was to replicate the association of five risk gene polymorphisms (PTPN22-rs2476601, STAT4-rs7574865, 6q23-rs6927172, IRF5-rs2004640 and TRAF1/C5-rs10818488) with RA in a specific population of the Western Algeria. The study group comprised 110 patients with RA and 197 ethnically matched healthy control subjects. All polymorphisms were genotyped using predesigned TaqMan® assays. Allele and genotype frequencies in patients and control subjects were compared by chi-square test and odds ratios with 95% confidence intervals. Correction for multiple testing was carried out using the Bonferroni adjustment. Statistically significant associations with RA were detected. The strongest signal was obtained for PTPN22-rs2476601 with an allelic Pvalue 3.32 x 10(-11) (OR = 9.83, 95% CI [4.28 - 22.56]). A second significant association was obtained with STAT4-rs7574865 (allelic Pvalue = 4 x 10(-3); OR = 1.75, 95% CI [1.16 - 2.63]). The third SNP, 6q23-rs6927172, showed a significant result of association with RA, but missed our criteria for significance at allelic level after Bonferroni's correction (allelic Pvalue = 0.027; OR = 0.64, 95% CI [0.42 - 0.97]). Finally, IRF5-rs2004640 and TRAF1/C5-rs10818488 showed a significant association only at genotypic level (Pvalues: 3 x 10(-4) and 2.9 x 10(-3) respectively) but did not reach statistical significance when comparing allele frequencies (Pvalues: 0.96 and 0.21 respectively). From this initial study, we can conclude that PTPN22-rs2476601 and STAT4-rs7574865 polymorphisms are clearly associated with the risk of RA in the Western Algerian population.
Directory of Open Access Journals (Sweden)
Mostefa FODIL
2015-01-01
Full Text Available Aim: The aim of the present study was to replicate the association of five risk gene polymorphisms (PTPN22-rs2476601, STAT4-rs7574865, 6q23-rs6927172, IRF5-rs2004640 and TRAF1/C5-rs10818488 with RA in a specific population of the Western Algeria. Material and methods: The study group comprised 110 patients with RA and 197 ethnically matched healthy control subjects. All polymorphisms were genotyped using predesigned TaqMan® assays. Allele and genotype frequencies in patients and control subjects were compared by chi-square test and odds ratios with 95% confidence intervals. Correction for multiple testing was carried out using the Bonferroni adjustment. Results: Statistically significant associations with RA were detected. The strongest signal was obtained for PTPN22-rs2476601 with an allelic Pvalue 3.32 x 10-11 (OR = 9.83, 95% CI [4.28 – 22.56]. A second significant association was obtained with STAT4-rs7574865 (allelic Pvalue = 4 x 10-3; OR = 1.75, 95% CI [1.16 – 2.63]. The third SNP, 6q23-rs6927172, showed a significant result of association with RA, but missed our criteria for significance at allelic level after Bonferroni’s correction (allelic Pvalue = 0.027; OR = 0.64, 95% CI [0.42 – 0.97]. Finally, IRF5-rs2004640 and TRAF1/C5-rs10818488 showed a significant association only at genotypic level (Pvalues: 3 x 10-4 and 2.9 x 10-3 respectively but did not reach statistical significance when comparing allele frequencies (Pvalues: 0.96 and 0.21 respectively. Conclusions: From this initial study, we can conclude that PTPN22-rs2476601 and STAT4-rs7574865 polymorphisms are clearly associated with the risk of RA in the Western Algerian population.
International Nuclear Information System (INIS)
1992-01-01
This document contains protocol 1 to the agreement among the European Atomic Energy Community, the government of Japan, the Government of the Russian Federation, and the Government of the United States of America on cooperation in the engineering design activities for the International Thermonuclear Experimental Reactor, which activities shall be conducted under the auspices of the International Atomic Energy Agency
Stabilization of burn conditions in a thermonuclear reactor using artificial neural networks
Vitela, Javier E.; Martinell, Julio J.
1998-02-01
In this work we develop an artificial neural network (ANN) for the feedback stabilization of a thermonuclear reactor at nearly ignited burn conditions. A volume-averaged zero-dimensional nonlinear model is used to represent the time evolution of the electron density, the relative density of alpha particles and the temperature of the plasma, where a particular scaling law for the energy confinement time previously used by other authors, was adopted. The control actions include the concurrent modulation of the D-T refuelling rate, the injection of a neutral He-4 beam and an auxiliary heating power modulation, which are constrained to take values within a maximum and minimum levels. For this purpose a feedforward multilayer artificial neural network with sigmoidal activation function is trained using a back-propagation through-time technique. Numerical examples are used to illustrate the behaviour of the resulting ANN-dynamical system configuration. It is concluded that the resulting ANN can successfully stabilize the nonlinear model of the thermonuclear reactor at nearly ignited conditions for temperature and density departures significantly far from their nominal operating values. The NN-dynamical system configuration is shown to be robust with respect to the thermalization time of the alpha particles for perturbations within the region used to train the NN.
Stabilization of burn conditions in a thermonuclear reactor using artificial neural networks
International Nuclear Information System (INIS)
Vitela, J.E.; Martinell, J.J.
1998-01-01
In this work we develop an artificial neural network (ANN) for the feedback stabilization of a thermonuclear reactor at nearly ignited burn conditions. A volume-averaged zero-dimensional nonlinear model is used to represent the time evolution of the electron density, the relative density of alpha particles and the temperature of the plasma, where a particular scaling law for the energy confinement time previously used by other authors, was adopted. The control actions include the concurrent modulation of the D-T refuelling rate, the injection of a neutral He-4 beam and an auxiliary heating power modulation, which are constrained to take values within a maximum and minimum levels. For this purpose a feedforward multilayer artificial neural network with sigmoidal activation function is trained using a back-propagation through-time technique. Numerical examples are used to illustrate the behaviour of the resulting ANN-dynamical system configuration. It is concluded that the resulting ANN can successfully stabilize the nonlinear model of the thermonuclear reactor at nearly ignited conditions for temperature and density departures significantly far from their nominal operating values. The NN-dynamical system configuration is shown to be robust with respect to the thermalization time of the alpha particles for perturbations within the region used to train the NN. (author)
Spiral Disk Instability Can Drive Thermonuclear Explosions in Binary White Dwarf Mergers
Kashyap, Rahul; Fisher, Robert; García-Berro, Enrique; Aznar-Siguán, Gabriela; Ji, Suoqing; Lorén-Aguilar, Pablo
2015-01-01
Thermonuclear, or Type Ia supernovae (SNe Ia), originate from the explosion of carbon-oxygen white dwarfs, and serve as standardizable cosmological candles. However, despite their importance, the nature of the progenitor systems that give rise to SNe Ia has not been hitherto elucidated. Observational evidence favors the double-degenerate channel in which merging white dwarf binaries lead to SNe Ia. Furthermore, significant discrepancies exist between observations and theory, and to date, ther...
The NC3Rs gateway: Accelerating scientific discoveries with new 3Rs models and technologies.
Percie du Sert, Nathalie; Robinson, Vicky
2018-01-01
This editorial introduces the NC3Rs gateway, which publishes articles and reviews on new models and technologies emerging from NC3Rs-funded research. The aim is to raise awareness about these approaches, increase confidence in their capability, and provide sufficient information to facilitate their uptake by others.
Thermonuclear runaways in thick hydrogen rich envelopes of neutron stars
Starrfield, S. G.; Kenyon, S.; Truran, J. W.; Sparks, W. M.
1981-01-01
A Lagrangian, fully implicit, one dimensional hydrodynamic computer code was used to evolve thermonuclear runaways in the accreted hydrogen rich envelopes of 1.0 Msub solar neutron stars with radii of 10 km and 20 km. Simulations produce outbursts which last from about 750 seconds to about one week. Peak effective temeratures and luninosities were 26 million K and 80 thousand Lsub solar for the 10 km study and 5.3 millison and 600 Lsub solar for the 20 km study. Hydrodynamic expansion on the 10 km neutron star produced a precursor lasting about one ten thousandth seconds.
BAYESIAN ESTIMATION OF THERMONUCLEAR REACTION RATES
Energy Technology Data Exchange (ETDEWEB)
Iliadis, C.; Anderson, K. S. [Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3255 (United States); Coc, A. [Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), CNRS/IN2P3, Univ. Paris-Sud, Université Paris–Saclay, Bâtiment 104, F-91405 Orsay Campus (France); Timmes, F. X.; Starrfield, S., E-mail: iliadis@unc.edu [School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287-1504 (United States)
2016-11-01
The problem of estimating non-resonant astrophysical S -factors and thermonuclear reaction rates, based on measured nuclear cross sections, is of major interest for nuclear energy generation, neutrino physics, and element synthesis. Many different methods have been applied to this problem in the past, almost all of them based on traditional statistics. Bayesian methods, on the other hand, are now in widespread use in the physical sciences. In astronomy, for example, Bayesian statistics is applied to the observation of extrasolar planets, gravitational waves, and Type Ia supernovae. However, nuclear physics, in particular, has been slow to adopt Bayesian methods. We present astrophysical S -factors and reaction rates based on Bayesian statistics. We develop a framework that incorporates robust parameter estimation, systematic effects, and non-Gaussian uncertainties in a consistent manner. The method is applied to the reactions d(p, γ ){sup 3}He, {sup 3}He({sup 3}He,2p){sup 4}He, and {sup 3}He( α , γ ){sup 7}Be, important for deuterium burning, solar neutrinos, and Big Bang nucleosynthesis.
Papailiou, D. D. (Editor)
1975-01-01
Concepts are described that presently appear to have the potential for propulsion applications in the post-1990 era of space technology. The studies are still in progress, and only the current status of investigation is presented. The topics for possible propulsion application are lasers, nuclear fusion, matter-antimatter annihilation, electronically excited helium, energy exchange through the interaction of various fields, laser propagation, and thermonuclear fusion technology.
Chai, H C; Phipps, M E; Othman, I; Tan, L P; Chua, K H
2013-02-01
Human leukocyte antigen (HLA) antigens and genes have long been reported associated with systemic lupus erythematosus (SLE) susceptibility in many populations. With the advance in technologies such as genome-wide association studies, many newly discovered SLE-associated single-nucleotide polymorphisms (SNPs) have been reported in recent years. These include HLA-DRB1/HLA-DQA1 rs9271366 and HLA-DQB1/HLA-DQA2 rs9275328. Our aim was to investigate these SNPs in a Malaysian SLE cohort. SNPs rs9271366 and rs9275328 were screened across 790 Malaysian citizens from three ethnic groups (360 patients and 430 healthy volunteers) by Taqman SNP genotyping assays. Allele and genotyping frequencies, Hardy-Weinberg equilibrium, Fisher's exact test and odds ratio were calculated for each SNP and ethnic group. Linkage disequilibrium and interaction between the two SNPs were also evaluated. The minor allele G and its homozygous genotype GG of HLA-DRB1/HLA-DQA1 rs9271366 significantly increased the SLE susceptibility in Malaysian patients, including those of Malay and Chinese ethnicity (odds ratio (OR) > 1, p < 0.05). As for HLA-DQB1/HLA-DQA2 rs9275328, the minor allele T and the heterozygous genotype CT conferred protective effect to SLE in Malaysians, as well as in Malays and Chinese, by having OR < 1 and p value <0.05. Both SNPs did not show associations to SLE in Indians. D' and r (2) values for the two SNPs in LD analysis were 0.941 and 0.065, respectively, with haplotype GC and AT being significantly associated with SLE (p < 5.0 × 10(-4)) after 10,000 permutations were performed. The MDR test clustered the genotype combinations of GG and CC, and AG and CC of rs9271366 and rs9275328, accordingly, as high-risk group, and the two SNPs interacted redundantly by removing 1.96% of the entropy. Our findings suggest that in addition to some classical HLA variants, rs9271366 and rs9275328 are additional polymorphisms worth considering in the Malaysian and possibly in
Hashemi, Mohammad; Mokhtari, Mojgan; Yazdani-Shahrbabaki, Vajiheh; Danesh, Hiva; Bizhani, Fatemeh; Taheri, Mohsen
2018-03-14
It has been proposed that transcobalamin 2 (TCN2) and the transcobalamin 2 receptor (TCN2R) are associated with idiopathic recurrent spontaneous abortion (RSA). The aim of the present study was to investigate the impact of TCN2 rs1801198 and TCN2R rs2336573 polymorphism on RSA in a sample of Iranian population. This case-control study was done on 92 RSA patients and 93 normal, fertile women. Genotyping of the TCN2 rs1801198 and TCN2R rs2336573 variants was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The findings showed no significant association between the TCN2 rs1801198 and TCN2R rs2336573 polymorphisms and the risk/protection of RSA. Our results did not support an association between the TCN2 polymorphism and the risk of RSA in a sample of southeast Iranian population. Larger studies with different ethnicities are needed to evaluate the possible impact of TCN2 and TCN2R polymorphisms on the pathogenesis of RSA. Impact statement What is already known on this subject? Recurrent spontaneous abortion (RSA), a multifactorial condition, is one of the most common complications of pregnancy. It has been proposed that genetic polymorphisms play a role in the pathogenesis of RSA. Few studies have examined the association between TNC2 and TCN2R polymorphisms and the RSA risk and the findings were inconsistent. The aim of the current study was to determine the possible association between the TCN2 rs1801198 and TCN2R rs2336573 polymorphisms and the RSA in a sample of the southeast Iranian population. What do the results of the study add? The findings of the present case-control study did not support an association between the TCN2 rs1801198 and TCN2R rs2336573 polymorphisms and the risk of RSA in a sample of the Iranian population. What are the implications of these findings for clinical practice and future research? The findings of this study may provide a basis for future studies with larger sample sizes and different ethnicities
Directory of Open Access Journals (Sweden)
Noriyuki eFuku
2015-05-01
Full Text Available There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR gene, rs1800795 in the interleukin-6 (IL6 gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1 gene. To gain insight into their functionality (which is yet unknown, here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n=138, age range 100-111 years (114 women] and healthy controls [n=334, 20-50 years (141 women] of the same ethnic and geographic origin (Spain. We also studied healthy centenarians [n=79, 100-104 years (40 women] and controls [n=316, 27-81 years (156 women] from Italy, and centenarians [n=742, 100-116 years (623 women] and healthy controls [n=499, 23-59 years (356 women] from Japan. The THRH rs7832552 T-allele and ACSL1 rs6552828 A-allele up-regulated luciferase activity compared to the C and G-allele, respectively (P≤0.001. Yet we found no significant association of EL with rs7832552, rs1800795 or rs6552828 in any of the 3 cohorts. Further research is needed with larger cohorts of centenarians of different origin as well as with younger old people.
Transport simulation of ITER [International Thermonuclear Engineering Reactor] startup
International Nuclear Information System (INIS)
Attenberger, S.E.; Houlberg, W.A.
1989-01-01
The present International Thermonuclear Engineering Reactor (ITER) reference configurations are the ''Technology Phase,'' in which the plasma current is maintained noninductively at a subignition density, and the ''Physics Phase,'' which is ignited but requires inductive maintenance of the current. The WHIST 1.5-D transport code is used to evaluate the volt-second requirements of both configurations. A slow current ramp (60-80's) is required for fixed-radius startup in ITER to avoid hollow current density profiles. To reach the operating point requires about 203 V·s for the Technology Phase (18 MA) and about 270 V·s for the Physics Phase (22 MA). The resistive losses can be reduced with expanding-radius startup. 5 refs., 4 figs
Laser induced sonofusion: A new road toward thermonuclear reactions
Energy Technology Data Exchange (ETDEWEB)
Sadighi-Bonabi, Rasoul, E-mail: Sadighi@sharif.ir [Sharif University of Technology, P.O. Box 11365-91, Tehran (Iran, Islamic Republic of); Gheshlaghi, Maryam [Payame noor University, P.O. Box 19395-3697, Tehran (Iran, Islamic Republic of); Laser and optics research school, Nuclear Science and Technology Research Institute (NSTRL), P.O. Box 14155-1339, Tehran (Iran, Islamic Republic of)
2016-03-15
The Possibility of the laser assisted sonofusion is studied via single bubble sonoluminescence (SBSL) in Deuterated acetone (C{sub 3}D{sub 6}O) using quasi-adiabatic and hydro-chemical simulations at the ambient temperatures of 0 and −28.5 °C. The interior temperature of the produced bubbles in Deuterated acetone is 1.6 × 10{sup 6} K in hydro-chemical model and it is reached up to 1.9 × 10{sup 6} K in the laser induced SBSL bubbles. Under these circumstances, temperature up to 10{sup 7} K can be produced in the center of the bubble in which the thermonuclear D-D fusion reactions are promising under the controlled conditions.
Role of redoximiRs in fibrogenesis.
Fierro-Fernández, Marta; Miguel, Verónica; Lamas, Santiago
2016-04-01
Fibrosis can be defined as an excessive accumulation of extracellular matrix (ECM) components, ultimately leading to stiffness, scarring and devitalized tissue. MicroRNAs (miRNAs) are short, 19-25 nucleotides (nt), non-coding RNAs involved in the post-transcriptional regulation of gene expression. Recently, miRNAs have also emerged as powerful regulators of fibrotic processes and have been termed "fibromiRs". Oxidative stress represents a self-perpetuating mechanism in fibrogenesis. MiRNAs can also influence the expression of genes responsible for the generation of reactive oxygen species (ROS) and antioxidant defence and are termed "redoximiRs". Here, we review the current knowledge of mechanisms by which "redoximiRs" regulate fibrogenesis. This new set of miRNAs may be called "redoxifibromiRs". Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.
The historical record for Sirius - Evidence for a white-dwarf thermonuclear runaway?
Bruhweiler, Frederick C.; Kondo, Yoji; Sion, Edward M.
1986-01-01
Evidence was recently presented that in medieval times Sirius was a bright red star, rather than the present bluish-white star. Here, the results of attempts to detect possible planetary nebula ejecta toward Sirius using data obtained by the IUE are presented. Based on these results and in the light of recent advances in understanding white-dwarf evolution, it is proposed that Sirius B underwent a recent thermonuclear runaway event triggered by a diffusion-induced CN reaction.
Guo, Min; Cheng, Zhifeng; Li, Changgui; Li, Shanshan; Li, Ming; Wang, Mingli; Xu, Jinmei; Tang, Yingying; Wang, Yujing; Qiu, Wenli; Liu, Xiaomin
2015-05-10
Gout is a genetic or acquired metabolic disease caused by increase of uric acid synthesis resulted from purine metabolic abnormalities. Whether cGMP-dependent protein kinase 2 (cGKII/PRKG2) is correlated with gout remains controversial. The objective of the present study was to investigate whether there is a correlation between polymorphism of cGKII/PRKG2 and gout susceptibility of Han population in northern China. Four hundred and five male patients with gout in the case group and 429 controls in the control group were collected from the Department of Endocrinology and Metabolic Disease, the Fourth Affiliated Hospital of Harbin Medical University. A case-control study method was used to study the correlation between cGKII/PRKG2 polymorphism rs7688672 and rs10033237 and gout susceptibility. The genotype frequencies of rs7688672 and rs10033237 polymorphisms of cGKII/PRKG2 in the case group and the control group both were in accordance with Hardy-Weinberg equilibrium. There were significant differences of rs10033237 in the allele frequencies and genotype distributions (Pgout. Combined mutation sites AA(*) from rs7688672 and rs10033237 were negatively correlated with gout susceptibility, whereas haplotype GG(*) was positively correlated with gout susceptibility. In conclusion, patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout. With regard to haplotypes of rs10033237 and rs7688672, both AA(*) and GG(*) are related to gout. AA(*) is a gout susceptible gene, whereas GG(*) is a protective gene. Copyright © 2015 Elsevier B.V. All rights reserved.
Majeed, Raad H.; Oudah, Osamah N.
2018-05-01
Thermonuclear fusion reaction plays an important role in developing and construction any power plant system. Studying the physical behavior for the possible mechanism governed energies released by the fusion products to precise understanding the related kinematics. In this work a theoretical formula controlled the general applied thermonuclear fusion reactions is achieved to calculating the fusion products energy depending upon the reactants physical properties and therefore, one can calculate other parameters governed a given reaction. By using this formula, the energy spectrum of 4He produced from T-3He fusion reaction has been sketched with respect to reaction angle and incident energy ranged from (0.08-0.6) MeV.
Department of Thermonuclear Research annual report 1992
International Nuclear Information System (INIS)
Sadowski, M.; Pawlowicz, W.
1993-02-01
Department of Thermonuclear Research annual report 1992 presents the most important results of theoretical, experimental and technological studies carried out within a framework of the research program - Plasma Physics and an additional grant - Study of Surface Melting of Selected Materials with a Plasma stream (contract with the Committee for Scientific Research - KBN). Theoretical studies of tokamak edge plasmas, atomic collisions, heat transfer, and numerical codes, are shortly summarized. Experimental studies of X-rays and particles emitted from Plasma-Focus facilities, calibration of nuclear track detectors, optimization of PF discharges with additional gas targets, magnetic probe measurements, new diagnostic and experimental arrangements, as well as mass- and energy-analysis of ions from IONOTRON-type devices, are described. Also presented are technological studies, modernization of experimental facilities, design of new control systems, tests on uniformity and reproducibility of plasma streams as the formation of photovoltaic cells and modifications of solid surfaces by means of plasma streams from the IONOTRON and PF devices. (author)
Department of Thermonuclear Research annual report 1992
Energy Technology Data Exchange (ETDEWEB)
Sadowski, M; Pawlowicz, W [eds.; Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)
1993-02-01
Department of Thermonuclear Research annual report 1992 presents the most important results of theoretical, experimental and technological studies carried out within a framework of the research program - Plasma Physics and an additional grant - Study of Surface Melting of Selected Materials with a Plasma stream (contract with the Committee for Scientific Research - KBN). Theoretical studies of tokamak edge plasmas, atomic collisions, heat transfer, and numerical codes, are shortly summarized. Experimental studies of X-rays and particles emitted from Plasma-Focus facilities, calibration of nuclear track detectors, optimization of PF discharges with additional gas targets, magnetic probe measurements, new diagnostic and experimental arrangements, as well as mass- and energy-analysis of ions from IONOTRON-type devices, are described. Also presented are technological studies, modernization of experimental facilities, design of new control systems, tests on uniformity and reproducibility of plasma streams as the formation of photovoltaic cells and modifications of solid surfaces by means of plasma streams from the IONOTRON and PF devices. (author).
The International Thermonuclear Experimental Reactor configuration evolution
International Nuclear Information System (INIS)
Lousteau, D.C.; Nelson, B.E.; Lee, V.D.; Thomson, S.L.; Miller, J.M.; Lindquist, W.B.
1989-01-01
The International Thermonuclear Experimental Reactor (ITER) conceptual design activities consist of two phases: a definition phase, completed in September 1988, and a design phase, now in progress. The definition phase was successful in identifying a consistent set of technical characteristics and the broad definition of the required reactor configuration and hardware. Scheduled for completion in November 1990, the design phase is producing a more detailed definition of the required components, a first cost estimate, and a description of site requirements. A major activity in the ITER design phase is the period of joint work conducted at the Max Planck Institute for Plasma Physics, Garching, Federal Republic of Germany, from June through October 1989. An official report of the findings and conclusions of this activity will be submitted to and published by the International Atomic Energy Agency (IAEA). This paper highlights the evolution of the reactor mechanical configuration since the conclusion of the definition phase. 8 figs., 2 tabs
Vacuum exhaust duct used for thermonuclear device
International Nuclear Information System (INIS)
Tachikawa, Nobuo; Kondo, Mitsuaki; Honda, Tsutomu.
1990-01-01
The present invention concerns a vacuum exhaust duct used for a thermonuclear device. A cylindrical metal liners is lined with a gap to the inside of a vacuum exhaust duct main body. Bellows are connected to both ends of the metal liners and the end of the bellows is welded to the vacuum exhaust duct main body. Futher, a heater is mounted to the metal liner on the side of the vacuum exhaust duct main body, and the metal liner is heated by the heater to conduct baking for the vacuum exhaust duct main body. Accordingly, since there is no requirement for elevating the temperature of the vacuum exhaust duct upon conducting baking, the vacuum exhaust duct scarcely suffers substantial deformation due to heat expansion. Further, there is also no substantial deformation for the bellows disposed between the outer circumference of the vacuum vessel and a portion of a vacuum exhaust duct, so that the durability of the bellows is greatly improved. (I.S.)
International Nuclear Information System (INIS)
Anon.
1981-01-01
The thermonuclear fusion is in a early development state and has, however, in principle possible advantages which could be especially valuable for Europe: the primary fusion fuels (D, Li) are plentiful existent, wide spread and cheap (1 g natural Lithium could generate 15 MWh); both fuels and the end product of the reactions - Helium - are stable. From the nuclear-technological point of view a thermonuclear reactor could be built with high safety; the doubling time for breeding of new fuels in principle could be very short. These potential advantages, however, are balanced by certain disadvantages, e.g. high costs for the construction of a thermonuclear reactor etc. The research program, other possibilities and the costs are outlined. (orig./HT) [de
DEFF Research Database (Denmark)
Fernandez, Luca; Jenssen, Håvard; Bains, Manjeet
2012-01-01
dependency on the CprRS and ParRS systems in a concentration-dependent manner. It was further demonstrated that, following exposure to inducing antimicrobial peptides, cprRS mutants did not become adaptively resistant to polymyxins as was observed for wild-type cells. Our microarray studies demonstrated...
Matching of experimental and statistical-model thermonuclear reaction rates at high temperatures
International Nuclear Information System (INIS)
Newton, J. R.; Longland, R.; Iliadis, C.
2008-01-01
We address the problem of extrapolating experimental thermonuclear reaction rates toward high stellar temperatures (T>1 GK) by using statistical model (Hauser-Feshbach) results. Reliable reaction rates at such temperatures are required for studies of advanced stellar burning stages, supernovae, and x-ray bursts. Generally accepted methods are based on the concept of a Gamow peak. We follow recent ideas that emphasized the fundamental shortcomings of the Gamow peak concept for narrow resonances at high stellar temperatures. Our new method defines the effective thermonuclear energy range (ETER) by using the 8th, 50th, and 92nd percentiles of the cumulative distribution of fractional resonant reaction rate contributions. This definition is unambiguous and has a straightforward probability interpretation. The ETER is used to define a temperature at which Hauser-Feshbach rates can be matched to experimental rates. This matching temperature is usually much higher compared to previous estimates that employed the Gamow peak concept. We suggest that an increased matching temperature provides more reliable extrapolated reaction rates since Hauser-Feshbach results are more trustwhorthy the higher the temperature. Our ideas are applied to 21 (p,γ), (p,α), and (α,γ) reactions on A=20-40 target nuclei. For many of the cases studied here, our extrapolated reaction rates at high temperatures differ significantly from those obtained using the Gamow peak concept
Nuclear-reaction rates in the thermonuclear runaway phase of accreting neutron stars
International Nuclear Information System (INIS)
Wiescher, M.; Barnard, V.; Goerres, J.; Fisker, J.L.; Martinez-Pinedo, G.; Langanke, K.; Rembges, F.; Thielemann, F.K.; Schatz, H.
2002-01-01
The rp-process has been suggested as the dominant nucleosynthesis process in explosive hydrogen burning at high temperature and density conditions. The process is characterized by a sequence of fast proton capture reactions and subsequent β-decays. The reaction path of the rp-process runs along the drip line up to Z∼50. Most of the charged-particle reaction rates for the reaction path are presently based on statistical Hauser-Feshbach calculations. While these rates are supposed to be reliable within a factor of two for conditions of high density in the compound nuclei, discrepancies may occur for nuclei near closed shells or near the proton drip line where the Q-values of proton capture processes are typically very small. It has been argued that the thermonuclear runaway is less sensitive to the reaction rates because of the rapid time-scale of the event. However, since these processes may operate at the same time-scale as fast mixing and convection processes, a change in reaction rates indeed may have a significant impact. In this paper we present two examples, the break-out from the hot CNO cycles, and the thermonuclear runaway in X-ray bursts itself, where changes in reaction rates have a direct impact on time-scale, energy generation and nucleosynthesis predictions for the explosive event. (orig.)
Structure of pipeline or duct for thermonuclear reactor
International Nuclear Information System (INIS)
Yamazaki, Seiichiro; Kobayashi, Takeshi; Fujioka, Junzo; Nishio, Satoshi; Okawa, Yoshinao; Sato, Keisuke.
1992-01-01
An electrically insulating material comprising a gradient function material is bonded metallurgically to a pipeline or a duct to be disposed to a magnetic field-confining type thermonuclear reactor. The gradient material has an ingredient approximate to ceramics on the side of an electrically insulative ceramic portion and an ingredient approximate to a metal on the other side. The intermediate portion between them, has a continuous gradient ingredient. Further, in the gradient portion of the electrically insulative portion, a heat expansion coefficient is also varied continuously or stepwise in addition to the electrical insulative property. Accordingly, even when a temperature distribution is caused during operation and welding upon production, thermal stresses applied to the pipelines is moderated. Further, since the electrically insulative ceramics are interposed with no support by an electric conductor, sufficient electrical insulation can be ensured. (T.M.)
International Nuclear Information System (INIS)
Derentowicz, H.; Kaliski, S.; Wolski, J.; Ziolkowski, Z.
1977-01-01
This paper presents the experimental results of the generation of a thermonuclear fusion neutrons by means of explosion. The experimental set is based on a quasi-spherical experiment in which a polyethylene layer is shot into a conic region hollowed out in a golden target and filled with deuterium gas. The speeding-up system is based on shooting the conic liner onto the surface of the Cu cone in which the Mach wave is generated and propagates along the cone axis leading to an implosion velocity of the polyethylene layer of the order of (4 - 5).10 6 cm/s. This affords a 10 3 -multiple compression of the D 2 gas (p 0 approximately 1.2 atm) and a neutron emission of the order of 3.10 7 from a mass of about 10 -7 g. This result is in full agreement with theoretical estimates. This is the first published and documented experiment in which a neutron stream of thermonuclear fusion was obtained by means of a pure explosion. (author)
ITER [International Thermonuclear Experimental Reactor] reactor building design study
International Nuclear Information System (INIS)
Thomson, S.L.; Blevins, J.D.; Delisle, M.W.
1989-01-01
The International Thermonuclear Experimental Reactor (ITER) is at the midpoint of a two-year conceptual design. The ITER reactor building is a reinforced concrete structure that houses the tokamak and associated equipment and systems and forms a barrier between the tokamak and the external environment. It provides radiation shielding and controls the release of radioactive materials to the environment during both routine operations and accidents. The building protects the tokamak from external events, such as earthquakes or aircraft strikes. The reactor building requirements have been developed from the component designs and the preliminary safety analysis. The equipment requirements, tritium confinement, and biological shielding have been studied. The building design in progress requires continuous iteraction with the component and system designs and with the safety analysis. 8 figs
Schnor, Noa Pereira Prada; Verlengia, Rozangela; Novais, Patrícia Fátima Sousa; Crisp, Alex Harley; Leite, Celso Vieira de Souza; Rasera-Junior, Irineu; Oliveira, Maria Rita Marques de
2017-01-01
Obesity can cause systemic arterial hypertension (SAH) and type 2 diabetes mellitus (DM2) factor that is also influenced by genetic variability. The present study aims to investigate the association between gene polymorphisms related with obesity on the prevalence of SAH and DM2 in the preoperative period and 1 year after Roux-en-Y gastric bypass surgery. In total, 351 obese women in a Brazilian cohort completed the study. The clinical diagnosis of SAH and DM2 was monitored from medical records. Twelve gene polymorphisms (rs26802; rs572169; rs7799039; rs1137101; rs3813929; rs659366; rs660339; rs1800849; rs7498665; rs35874116; rs9701796; and rs9939609) were determined using real-time polymerase chain reaction and TaqMan assay. In the preoperative period, prevalence of SAH and DM2 was 57% and 22%, respectively. One year postoperatively, 86.8% subjects had remission of DM2 and 99.5% had control of SAH. Subjects with T allele from the serotonin receptor gene (5-HT2C, rs3813929) had five times greater chance of DM2, and the CC genotype from uncoupling protein 3 gene (UCP3, rs1800849) had three times greater chance in the preoperative period. These findings indicate that polymorphisms rs3813929 and rs1800849 from 5-HT2C and UCP3 genes were related to DM2 prevalence among the Brazilian obese women candidates for bariatric surgery.
Thermonuclear generation program: risks and safety
International Nuclear Information System (INIS)
Goes, Alexandre Gromann de Araujo
1999-01-01
This work deals with the fundamental concepts of risk and safety related to nuclear power generation. In the first chapter, a general evaluation of the various systems for energy generation and their environmental impacts is made. Some definitions for safety and risk are suggested, based on the already existing regulatory processes and also on the current tendencies of risk management. Aspects regarding the safety culture are commented. The International Nuclear Event Scale (INES), a coherent and clear mechanism of communication between nuclear specialists and the general public, is analyzed. The second chapter examines the thermonuclear generation program in Brazil and the role of the National Nuclear Energy Commission. The third chapter presents national and international scenarios in terms of safety and risks, available policies and the main obstacles for future development of nuclear energy and nuclear engineering, and strategies are proposed. In the last chapter, comments about possible trends and recommendations related to practical risk management procedures, taking into account rational criteria for resources distribution and risk reduction are made, envisaging a closer integration between nuclear specialists and the society as a whole, thus decreasing the conflicts in a democratic decision-making process
Wang, Hong; Hua, Mingqiang; Wang, Shukang; Yu, Jie; Chen, Chen; Zhao, Xueyun; Zhang, Chen; Zhong, Chaoqin; Wang, Ruiqing; He, Na; Hou, Ming; Ma, Daoxin
2017-03-01
Though the pathogenesis of AML is still unknown, accumulating evidence revealed that immune response plays a vital part in it. NLRP3 inflammasome as a component of immune system has been found related to several cancers. The single nucleotide polymorphisms (SNPs) of NLRP3 inflammasome genes may be related to pathogenesis and prognosis of AML. We determined polymorphisms of NLRP3 (rs35829419), CARD8 (rs2043211), IL-1β (rs16944), IL-18 (rs1946518) and NF-κB -94 ins/del ATTG in de novo AML patients to find out whether they play roles in the susceptibility and severity of AML. In our study, 383 AML cases and 300 randomly selected healthy individuals were examined for the polymorphisms and expression of NLRP3 genes. IL-1β (rs16944) polymorphism in different risk AML subgroups was found statistically different, with more GA genotype in favorable-risk cytogenetics group. We also demonstrated that the bone marrow blasts of patients carrying IL-18 (rs1946518) GG or GT genotype were higher than patients of TT genotype. IL-18 plasma level of patients with IL-18 (rs1946518) GT or TT genotype was higher than GG genotype. Moreover, the GT genotype of IL-18 (rs1946518) led to statistically poorer AML-specific survival. IL-1β (rs16944) and IL-18 (rs1946518) may be served as potential predictors for AML.
Directory of Open Access Journals (Sweden)
Galina Lurie
2011-02-01
Full Text Available Overweight and obesity are strongly associated with endometrial cancer. Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity. We examined the association of FTO rs9939609 and MC4R rs17782313 with endometrial cancer risk in a pooled analysis of nine case-control studies within the Epidemiology of Endometrial Cancer Consortium (E2C2. This analysis included 3601 non-Hispanic white women with histologically-confirmed endometrial carcinoma and 5275 frequency-matched controls. Unconditional logistic regression models were used to assess the relation of FTO rs9939609 and MC4R rs17782313 genotypes to the risk of endometrial cancer. Among control women, both the FTO rs9939609 A and MC4R rs17782313 C alleles were associated with a 16% increased risk of being overweight (p = 0.001 and p = 0.004, respectively. In case-control analyses, carriers of the FTO rs9939609 AA genotype were at increased risk of endometrial carcinoma compared to women with the TT genotype [odds ratio (OR = 1.17; 95% confidence interval (CI: 1.03-1.32, p = 0.01]. However, this association was no longer apparent after adjusting for body mass index (BMI, suggesting mediation of the gene-disease effect through body weight. The MC4R rs17782313 polymorphism was not related to endometrial cancer risk (per allele OR = 0.98; 95% CI: 0.91-1.06; p = 0.68. FTO rs9939609 is a susceptibility marker for white non-Hispanic women at higher risk of endometrial cancer. Although FTO rs9939609 alone might have limited clinical or public health significance for identifying women at high risk for endometrial cancer beyond that of excess body weight, further investigation of obesity-related genetic markers might help to identify the pathways that influence endometrial carcinogenesis.
Zhang, Rui-Nan; Zheng, Rui-Dan; Mi, Yu-Qiang; Zhou, Da; Shen, Feng; Chen, Guang-Yu; Zhu, Chan-Yan; Pan, Qin; Fan, Jian-Gao
2016-08-01
The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD in Chinese. Fifty-nine liver biopsy-proven NAFLD patients and 72 healthy control subjects were recruited to a cohort representing Chinese Han population. The polymorphisms in the exons and flanking regions of APOC3 and patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphisms were genotyped. Among the five SNPs (rs4225, rs4520, rs5128, rs2070666, and rs2070667) in APOC3, only rs2070666 (c.179 + 62 T/A) was significantly different in genotype and allele frequency (both p steatosis (OR 4.986, 95 % CI 1.020-24.371), but neither to liver stiffness measurement values nor to hepatic histological activity and fibrosis in NAFLD patients. The APOC3 rs2070666 A allele is a risk factor for NAFLD independent of obesity, dyslipidemia, and PNPLA3 rs738409, and it might contribute to increased liver fat content in Chinese Han population.
Elshazli, Rami; Settin, Ahmad
2015-08-01
Rheumatoid arthritis (RA) is a common autoimmune disease with a complex genetic background. The genes encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) and signal transducer and activator of transcription 4 (STAT4) have been reported to be associated with RA in several ethnic populations. This work aims to assess the association between PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with RA susceptibility through an updated meta-analysis of available case-control studies. A literature search of all relevant studies published from January 2007 up to December 2014 was conducted using Pubmed and Science Direct databases. The observed studies that were related to an association between PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with RA susceptibility were identified. Meta-analysis of the pooled and stratified data was done and assessed using varied genetic models. Thirty-seven case-control studies with a total of 47 comparisons (29 for PTPN22 rs2476601 polymorphism and 18 for STAT4 rs7574865 polymorphism) met our inclusion criteria. The meta-analysis showed an association between PTPN22 T allele, CT+TT and TT genotypes with RA susceptibility. Furthermore, The meta-analysis showed an association between STAT4 T allele, GT+TT and TT genotypes with RA susceptibility. Stratification of RA patients according to ethnic groups showed that PTPN22 T allele, CT+TT genotypes, STAT4 T allele and STAT4 GT+TT were significantly associated with RA in European, Asian, African subjects, while PTPN22 TT genotype was significantly associated with RA in European but not in Asian and African subjects and STAT4 TT genotype was significantly associated with RA in European and Asian but not in African subject. A subgroup analysis according to the presence or absence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies revealed that the association between PTPN22 rs2476601 and STAT4 rs7574865 polymorphisms with RA susceptibility
Zhou, Xin; Wang, Chunrong; Chen, Zhao; Peng, Yun; Peng, Huirong; Hou, Xuan; Ye, Wei; Qiu, Rong; Xia, Kun; Tang, Beisha; Jiang, Hong
2018-01-07
Recent evidence suggested that several single nucleotide polymorphisms (SNPs) of inflammation-related genes (TNF-α rs1799964, IL-1α rs1800587, IL-1β rs16944, IL-8 rs4073, ICAM-1 rs5498) were associated with multiple system atrophy (MSA). Herein, we conducted this case-control study to evaluate the possible correlation between the five SNPs related to inflammation and MSA in Chinese Han population. We recruited 154 sporadic patients with MSA and 223 health controls in this study. All subjects were genotyped for the five SNPs using polymerase chain reaction amplification and Sanger sequencing. TNF-α rs1799964, genotype distribution and minor allele frequency (MAF) showed significant differences between patients and controls, which might illustrate the minor allele C may increase the risk for MSA (genotype, P = 0.006, OR = 1.245, 95% CI = [1.066-1.455]; allele, P = 0.001, OR = 1.887, 95% CI = [1.303-2.733]). For rs16944, patients carrying AA genotype showed a nearly 5-year early age at onset (AAO) than GG genotype (50.52 ± 7.45 years vs. 54.90 ± 7.21 years, P = 0.037). No differences were found in genotype distribution and MAF of the five SNPs between patients with MSA with predominant cerebellar ataxia (MSA-C) and with predominant Parkinsonism (MSA-P). Our study suggests that rs1799964 of TNF-α may act as a risk factor for MSA and the IL-1β rs16944 might be a genetic factor that modifies the AAO in MSA. Moreover, the exact mechanism of neuroinflammatory response in MSA deserves further exploration.
Tang, Ren-Guang; Huang, Yong-Zhi; Yao, Li-Min; Xiao, Jian; Lu, Chuan; Yu, Qian
2013-01-01
Epidemiological evidence has shown two polymorphisms (namely RS#1800468G>A and RS#1800471G>C) of transforming growth factor-beta 1 (TGF-β1) gene may be involved in the cancer development. However, their role in the carcinogenic process of esophageal squamous cell carcinoma (ESCC) has been less well elaborated. We conducted a hospital-based case-control study including 391 ESCC cases and 508 controls without any evidence of tumors to evaluate the association between these two polymorphisms and ESCC risk and prognosis for Zhuangese population by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and amplification refractory mutation system (ARMS)-PCR techniques. We found that individuals with the genotypes with RS#1800471 C allele (namely RS#1800471-GC or -CC) had an increased risk of ESCC than those without above genotypes (namely RS#1800471-GG, adjusted odds ratio 3.26 and 5.65, respectively). Further stratification analysis showed that this polymorphism was correlated with tumor histological grades and TNM (tumor, node, and metastasis) stage, and modified the serum levels of TGF-β1. Additionally, RS#1800471 polymorphism affected ESCC prognosis (hazard ratio, 3.40), especially under high serum levels of TGF-β1 conditions. However, RS#1800468 polymorphism was not significantly related to ESCC risk. These findings indicated that TGF-β1 RS#1800471G>C polymorphism may be a genetic modifier for developing ESCC in Zhuangese population. Copyright © 2012 Elsevier B.V. All rights reserved.
A high-recycle divertor for ITER [International Thermonuclear Experimental Reactor
International Nuclear Information System (INIS)
Werley, K.A.; Bathke, C.G.
1988-01-01
A coupled one-dimensional (axial/radial) edge-plasma model (SOLAR) has been used to investigate tradeoffs between collector-plate and edge-plasma conditions in a doublenull, open, high-recycle divertor (HRD) for a preliminary International Thermonuclear Experimental Reactor (ITER) design. A steady-state HRD produces in attractive high-density edge plasma (5 /times/ 10 19 m/sup /minus/3/) with sufficiently low plasma temperature (10-20eV) at a tungsten plat that the sheath-accelerated ions are below sputtering threshold energies. Manageable plate heat fluxes (3-6 MW/m 2 ) are achieved by positioning the plate poloidal cross section at a minimum angle of 15-30/degree/ with respect to flux surfaces. 6 refs., 9 figs
Charged-particle thermonuclear reaction rates: IV. Comparison to previous work
International Nuclear Information System (INIS)
Iliadis, C.; Longland, R.; Champagne, A.E.; Coc, A.
2010-01-01
We compare our Monte Carlo reaction rates (see Paper II of this issue) to previous results that were obtained by using the classical method of computing thermonuclear reaction rates. For each reaction, the comparison is presented using two types of graphs: the first shows the change in reaction rate uncertainties, while the second displays our new results normalized to the previously recommended reaction rate. We find that the rates have changed significantly for almost all reactions considered here. The changes are caused by (i) our new Monte Carlo method of computing reaction rates (see Paper I of this issue), and (ii) newly available nuclear physics information (see Paper III of this issue).
International Nuclear Information System (INIS)
Ludwig, Gerson Otto
2004-01-01
This document represents the 2003 activity report of the development and research line in controlled thermonuclear fusion of the Plasma Associated Laboratory - Brazil, approaching the areas of toroidal systems for magnetic confinement, plasma heating, current generation and high temperature plasma diagnostic
Issac, Marianne Samir M; Ashur, Wafaa; Mousa, Heba
2014-06-01
Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that involves the activity of various inflammatory cells and mediators. It has been suggested that susceptibility to COPD is, at least in part, genetically determined. The primary aim of this study was to investigate the association between surfactant protein D (SFTPD) rs2243639, interleukin (IL)-1β rs16944 and IL-1 receptor antagonist (IL-1RN) rs2234663 gene polymorphisms and COPD susceptibility, as well as examining the association between the various IL-1RN/IL-1β haplotypes and pulmonary function tests (PFT). Secondly, we aimed to examine the influence of SFTPD rs2243639 polymorphism on serum surfactant protein D (SP-D) level. A total of 114 subjects were recruited in this study and divided into three groups: 63 COPD patients, 25 asymptomatic smokers, and 26 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed for the detection of SFTPD rs2243639 and IL-1β rs16944 polymorphisms. Detection of variable numbers of an 86-bp tandem repeat (VNTR) of IL-1RN was done using PCR. Serum SP-D level was measured using enzyme linked-immunosorbent assay. PFTs were measured by spirometry. Carriers of the SFTPD AG and AA polymorphic genotypes constituted 71.4 % of COPD patients versus 48 % in asymptomatic smokers, with a statistically significant difference between the two groups (p = 0.049). Smokers who were carriers of the polymorphic SFTPD rs2243639 A allele (AG and AA genotypes) have a 2.708 times risk of developing COPD when compared with wild-type GG genotype carriers [odds ratio (OR) 2.708 (95 % CI 1.041-7.047)]. Forced expiratory flow (FEF) 25-75 % predicted was higher in IL-1RN*1/*1 when compared with *1/*2 (p = 0.013). FEF25-75 % predicted in carriers of haplotype IL-1RN *1/IL-1β T (49.21 ± 10.26) was statistically significantly higher than in carriers of IL-1RN *2/IL-1β T (39.67 ± 12.64) [p = 0
Operating large controlled thermonuclear fusion research facilities
International Nuclear Information System (INIS)
Gaudreau, M.P.J.; Tarrh, J.M.; Post, R.S.; Thomas, P.
1987-01-01
The MIT Tara Tandem Mirror is a large, state of the art controlled thermonuclear fusion research facility. Over the six years of its design, implementation, and operation, every effort was made to minimize cost and maximize performance by using the best and latest hardware, software, and scientific and operational techniques. After reviewing all major DOE fusion facilities, an independent DOE review committee concluded that the Tara operation was the most automated and efficient of all DOE facilities. This paper includes a review of the key elements of the Tara design, construction, operation, management, physics milestones, and funding that led to this success. The authors emphasize a chronological description of how the system evolved from the proposal stage to a mature device with an emphasis on the basic philosophies behind the implementation process. This description can serve both as a qualitative and quantitative database for future large experiment planning. It includes actual final costs and manpower spent as well as actual run and maintenance schedules, number of data shots, major system failures, etc. The paper concludes with recommendations for the next generation of facilities
High heat flux device of thermonuclear device
International Nuclear Information System (INIS)
Tachikawa, Nobuo.
1994-01-01
The present invention provides an equipments for high heat flux device (divertor) of a thermonuclear device, which absorbs thermal deformation during operation, has a high installation accuracy, and sufficiently withstands for thermal stresses. Namely, a heat sink member is joined to a structural base. Armour tiles are joined on the heat sink member. Cooling pipes are disposed between the heat sink member and the armour tiles. With such a constitution, the heat sink member using a highly heat conductive material having ductility, such as oxygen free copper, the cooling pipes using a material having excellent high temperature resistance and excellent elongation, such as aluminum-dispersed reinforced copper, and the armour tiles are completely joined on the structural base. Therefore, when thermal deformation tends to cause in the high heat flux device such as a divertor, cooling pipes cause no plastic deformation because of their high temperature resistance, but the heat sink member such as a oxygen free copper causes plastic deformation to absorb thermal deformation. As a result, the high heat flux device such as a divertor causes no deformation. (I.S.)
Controlled thermonuclear fusion reactors
International Nuclear Information System (INIS)
Walstrom, P.L.
1976-01-01
Controlled production of energy by fusion of light nuclei has been the goal of a large portion of the physics community since the 1950's. In order for a fusion reaction to take place, the fuel must be heated to a temperature of 100 million degrees Celsius. At this temperature, matter can exist only in the form of an almost fully ionized plasma. In order for the reaction to produce net power, the product of the density and energy confinement time must exceed a minimum value of 10 20 sec m -3 , the so-called Lawson criterion. Basically, two approaches are being taken to meet this criterion: inertial confinement and magnetic confinement. Inertial confinement is the basis of the laser fusion approach; a fuel pellet is imploded by intense laser beams from all sides and ignites. Magnetic confinement devices, which exist in a variety of geometries, rely upon electromagnetic forces on the charged particles of the plasma to keep the hot plasma from expanding. Of these devices, the most encouraging results have been achieved with a class of devices known as tokamaks. Recent successes with these devices have given plasma physicists confidence that scientific feasibility will be demonstrated in the next generation of tokamaks; however, an even larger effort will be required to make fusion power commercially feasible. As a result, emphasis in the controlled thermonuclear research program is beginning to shift from plasma physics to a new branch of nuclear engineering which can be called fusion engineering, in which instrumentation and control engineers will play a major role. Among the new problem areas they will deal with are plasma diagnostics and superconducting coil instrumentation
Directory of Open Access Journals (Sweden)
Zhang Q
2018-01-01
Full Text Available Qi-Wei Zhang Department of Neurosurgery, The Affiliated Hospital of Jilin Medical University, Jilin, People’s Republic of China Purpose: The relationship of the matrix metalloproteinase-3 (MMP-3 polymorphisms rs679620 and rs3025058 with ischemic stroke has received much attention. The aim of the present study was to perform a meta-analysis of published case–control studies to evaluate the cumulative evidence.Methods: We performed a search of ISI Web of Science, Embase, PubMed, and China National Knowledge Infrastructure databases. Pooled odds ratios (ORs were appropriately derived from fixed-effects or random-effects models.Results: We identified seven eligible studies including 5,204 subjects. The pooled analysis showed that the MMP-3 rs679620 A allele carriers had increased risk of ischemic stroke compared with homozygotes for the G allele in Asians (AA + GA vs GG: OR =1.42, 95% CI: 1.05–1.91, P=0.022. Concerning the rs3025058 polymorphism, the results did not suggest an association between rs3025058 genotypes and ischemic stroke risk (5A5A + 6A5A vs 6A6A: OR =1.04, 95% CI: 0.73–1.47, P=0.844; 5A5A vs 6A5A + 6A6A: OR =1.14, 95% CI: 0.74–1.77, P=0.556; and 5A5A vs 6A6A: OR =1.11, 95% CI: 0.68–1.80, P=0.677. In subgroup analysis by ethnicity, no statistically significant associations were demonstrated for rs3025058 in Asians and Caucasians, respectively. There was no evidence for publication bias.Conclusion: Our findings indicate that the rs679620 A allele carriers have increased risk of ischemic stroke in Asians, but there is no association between rs3025058 and ischemic stroke risk. Keywords: ischemic stroke, meta-analysis, MMP-3, polymorphism
International Nuclear Information System (INIS)
Hangel, G.
2007-03-01
An analysis of the influence of the thermonuclear pilot project ITER on Austrian research and industrial activities is presented in terms of the following subjects: fusion research history, ITER technique, security, nuclear fusion, ITER (reactor, project specifications for quotations), possibilities for Austrian companies and fusion research in Austria. (nevyjel)
Power source device for thermonuclear device
International Nuclear Information System (INIS)
Ozaki, Akira.
1992-01-01
The present invention provides a small sized and economical power source device for a thermonuclear device. That is, the device comprises a conversion device having a rated power determined by a power required during a plasma current excitation period and a conversion device having a rated power determined by a power required during a plasma current maintaining period, connected in series to each other. Then, for the former conversion device, power is supplied from an electric power generator and, for the latter, power is supplied from a power system. With such a constitution, during the plasma electric current maintaining period for substantially continuous operation, it is possible to conduct bypassing paired operation for the former conversion device while the electric power generator is put under no load. Further, since a short period rated power may be suffice for the former conversion device and the electric power generator having the great rated power required for the plasma electric current excitation period, they can be reduced in the size and made economical. On the other hand, since the power required for the plasma current maintaining period is relatively small, the capacity of the continuous rated conversion device may be small, and the power can be received from the power system. (I.S.)
Energy balance of controlled thermonuclear fusion
International Nuclear Information System (INIS)
Hashmi, M.; Staudenmaier, G.
2000-01-01
It is shown that a discrepancy and incompatibility persist between basic physics and fusion-literature regarding the radiation losses from a thermonuclear plasma. Whereas the fusion-literature neglects the excitation or line radiation completely, according to basic physics it depends upon the prevailing conditions and cannot be neglected in general. Moreover, for a magnetized plasma, while the fusion-literature assumes a self-absorption or reabsorption of cyclotron or synchrotron radiation emitted by the electrons spiraling along the magnetic field, the basic physics does not allow any effective reabsorption of cyclotron or synchrotron radiation. As is demonstrated, fallacious assumptions and notions, which somehow or other crept into the fusion-literature, are responsible for this discrepancy. In the present work, the theory is corrected. On the grounds of basic physics, a complete energy balance of magnetized and non-magnetized plasmas is presented for pulsed, stationary and self-sustaining operations by taking into account the energy release by reactions of light nuclei as well as different kinds of diffusive (conduction) and radiative (bremsstrahlung, cyclotron or synchrotron radiation and excitation radiation) energy losses. Already the energy losses by radiation make the energy balance negative. Hence, a fusion reactor-an energy producing device-seems to be beyond the realms of realization. (orig.)
Vacuum pumping for controlled thermonuclear reactors
International Nuclear Information System (INIS)
Watson, J.S.; Fisher, P.W.
1976-01-01
Thermonuclear reactors impose unique vacuum pumping problems involving very high pumping speeds, handling of hazardous materials (tritium), extreme cleanliness requirements, and quantitative recovery of pumped materials. Two principal pumping systems are required for a fusion reactor, a main vacuum system for evacuating the torus and a vacuum system for removing unaccelerated deuterium from neutral beam injectors. The first system must pump hydrogen isotopes and helium while the neutral beam system can operate by pumping only hydrogen isotopes (perhaps only deuterium). The most promising pumping techniques for both systems appear to be cryopumps, but different cryopumping techniques can be considered for each system. The main vacuum system will have to include cryosorption pumps cooled to 4.2 0 K to pump helium, but the unburned deuterium-tritium and other impurities could be pumped with cryocondensation panels (4.2 0 K) or cryosorption panels at higher temperatures. Since pumping speeds will be limited by conductance through the ducts and thermal shields, the pumping performance for both systems will be similar, and other factors such as refrigeration costs are likely to determine the choice. The vacuum pumping system for neutral beam injectors probably will not need to pump helium, and either condensation or higher temperature sorption pumps can be used
Thermonuclear burst oscillations: where firestorms meet fundamental physics.
CERN. Geneva
2017-01-01
Neutron stars offer a unique environment in which to develop and test theories of the strong force. Densities in neutron star cores can reach up to ten times the density of a normal atomic nucleus, and the stabilising effect of gravitational confinement permits long-timescale weak interactions. This generates matter that is neutron-rich, and opens up the possibility of stable states of strange matter, something that can only exist in neutron stars. Strong force physics is encoded in the Equation of State (EOS), the pressure-density relation, which links to macroscopic observables such as mass M and radius R via the stellar structure equations. By measuring and inverting the M-R relation we can recover the EOS and diagnose the underlying dense matter physics. One very promising technique for simultaneous measurement of M and R exploits hotspots (burst oscillations) that form on the neutron star surface when material accreted from a companion star undergoes a thermonuclear explosion (a Type I X-ray burst). As ...
Magnet systems for the International Thermonuclear Experimental Reactor
International Nuclear Information System (INIS)
Henning, C.D.; Miller, J.R.
1988-01-01
The definition phase for the International Thermonuclear Experimental Reactor (ITER) has been nearly completed, thus beginning a three-year design effort by teams from the European Community (EC), Japan, US, and USSR. Preliminary parameters for the superconducting magnet system have been established to guide more detailed design work. Radiation tolerance of the superconductors and insulators has been important because it sets requirements for the neutron-shield dimension and sensitively influences reactor size. Major levels of mechanical stress appear in the structural cases of the inboard legs of the toroidal-field (TF) coils. The winding packs of the TF coils include significant fractions of steel that provide support against in-plane separating loads, but they offer little support against out-of-plane loads unless shear-bonding of the conductors can be maintained. Heat removal from nuclear and ac loads has not limited the fundamental design, but it has nonnegligible economic consequences. 3 refs., 3 figs., 5 tabs
Blue energy - The story of thermonuclear fusion energy
International Nuclear Information System (INIS)
Laval, G.
2007-01-01
The author has written a story of thermonuclear fusion as a future source of energy. This story began about 50 years ago and its last milestone has been the decision of building the ITER machine. This decision has been taken by an international collaboration including a large part of the humanity which shows how great are the expectations put on fusion and that fusion deserves confidence now. For long years fusion energy has been the subject of large controversy due to the questioning about the overcoming of huge theoretical and technological difficulties. Different machines have been built to assess new theoretical developments and to prepare the next step. The physics of hot plasmas has been understood little by little at the pace of the discovery of new instabilities taking place in fusion plasmas. The 2 unique today options: the tokamak-type machine and the laser-driven inertial confinement machine took the lead relatively quickly. (A.C.)
Ignition and burn control characteristics of thermonuclear plasmas
International Nuclear Information System (INIS)
Chaniotakis, E.A.
1990-01-01
Achieving the long sought goal of fusion energy requires the attainment of an ignited and controlled thermonuclear plasma. Obtaining an ignited plasma in a tokamak device requires consideration of both the physics of the plasma and the engineering of the machine. With the aide of completely analytical procedure optimized and ignited tokamaks are obtained under various physics assumptions. These designs show the possible advantage of tokamaks characterized by high (∼4.5) aspect ratio, and high (∼15 T) toroidal magnetic field. The control of an ignited plasma is investigated by using auxiliary power modulation. With auxiliary power stable operating points can be created with Q ∼50. Recognizing the need for a fast 1 1/2-D transport model for studying profile effects the plasma transport equations are solved using variational methods. A computer model based on the variational method has been developed. This model solves the 1 1/2-D transport equation very fast with little loss of accuracy. 74 refs., 70 figs., 8 tabs
Zhang, Daofa; Xie, Maowei; Yang, Xiaohong; Zhang, Yin; Su, Yan; Wang, Yanni; Huang, Haiyang; Han, Hui; Li, Wenning; Fu, Keying; Su, Huiluan; Xu, Wentan; Han, Yeguang; Wang, Ru; Zhang, Pei; Wu, Wei; Huang, Yun; Chen, Daojun; Jin, Tianbo; Wei, Jiali
2017-09-22
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis. We genotype 10 single nucleotide polymorphisms (SNPs) in IL-1B and IL-6 gene using Sequenom Mass-ARRAY technology from 417 IgAN patients and 463 healthy controls of the Chinese Han population. We evaluated these SNPs associated with IgAN utilising the chi-square tests and genetic model analysis. We identified that the minor alleles of rs16944 ("A"), rs1800796 ("G") in IL-1B, IL-6 were involved in an increasingly risk of IgAN in allelic model analysis, respectively. The rs16944 in IL-1B and rs1800796 in IL-6 were associated with 1.23-fold (95% CI, 1.02-1.48, P = 0.031) and 1.33-fold (95% CI, 1.11-1.66, P = 0.003) increases in the risk of developing IgAN, respectively. There was only rs1800796 still correlated with IgAN in the allelic model after adjustment by age and gender and the Bonferroni correction. In addition, Haplotype G rs1800796 A rs2069837 G rs2069840 ( P = 0.037) and G rs1800796 A rs2069837 C rs2069840 ( P = 0.042) in IL-6 were considered to be associated with increased IgAN risk. This study verified the IL-6, IL-1B genetic variants polymorphisms contributed to IgAN susceptibility in a Chinese Han population. Although we identified SNPs susceptibility, however, replication studies and functional research are required to confirm the genetic contribution in IgAN.
Local wall power loading variations in thermonuclear fusion devices
International Nuclear Information System (INIS)
Carroll, M.C.; Miley, G.H.
1989-01-01
A 2 1/2-dimensional geometric model is presented that allows calculation of power loadings at various points on the first wall of a thermonuclear fusion device. Given average wall power loadings for brems-strahlung, cyclotron radiation charged particles, and neutrons, which are determined from various plasma-physics computation models, local wall heat loads are calculated by partitioning the plasma volume and surface into cells and superimposing the heating effects of the individual cells on selected first-wall differential areas. Heat loads from the entire plasma are thus determined as a function of position on the first-wall surface. Significant differences in local power loadings were found for most fusion designs, and it was therefore concluded that the effect of local power loading variations must be taken into account when calculating temperatures and heat transfer rates in fusion device first walls
Four therapeutic cases of RS3PE syndrome
International Nuclear Information System (INIS)
Nakajima, Naoya; Fukuda, Yukiko; Yang, Kwang-Seok; Aiba, Miyoji; Tsuda, Hiroshi
2007-01-01
RS3PE syndrome (Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome) is one of the disorders which present as polyarthritis. It is important to be aware of RS3PE syndrome when encountering elderly patients with polyarthritis who are negative for rheumatoid factor. We report 4 cases of RS3PE syndrome. All cases shared common clinical findings, such as acute onset, symmetrical polyarthritis, pitting edema of the hands and feet, and being negative for rheumatoid factor in serum. Treatment with corticosteroid was very effective in all cases. However, two patients showed a deteriorated clinical condition during the tapering of corticosteroid. Corticosteroid should be tapered off cautiously in patients with RS3PE syndrome. (author)
Directory of Open Access Journals (Sweden)
Yan Lin
Full Text Available BACKGROUND: The association between polymorphisms rs6265 and rs2030324 in brain-derived neurotrophic factor (BDNF and Alzheimer's disease (AD has been widely reported, but the results remain controversial. METHODS: A comprehensive search of Pubmed, Web of Science, China National Knowledge Infrastructure (CNKI, Wanfang Med Online and China Biology Medical literature database (CBM was performed. Pooled odds ratios (ORs with 95% confidence intervals (CIs were calculated using fixed or random-effects models. We excluded the studies with OR>3.0 or OR<0.3 for sensitive analysis. Subgroup analysis by ethnicity, form of AD and gender was carried out. Meta-regression was conducted to explore the potential sources of between-study heterogeneity. RESULTS: 29 articles with 7548 cases and 7334 controls concerning rs6265 and 22 articles with 5796 cases and 5706 controls concerning rs2030324 were included in this meta-analysis. The combined evidence suggested rs6265 contributing significantly to the increased risk of AD in females (codominant: fixed-effects model (FEM: OR = 1.13, 95% CI = 1.04-1.23; dominant: FEM: OR = 1.17, 95% CI = 1.05-1.31, especially for Caucasian females (codominant: FEM: OR = 1.18, 95% CI = 1.03-1.34; dominant: FEM: OR = 1.18, 95% CI = 1.01-1.37 and female late-onset Alzheimer's disease (LOAD patients (codominant: FEM: OR = 1.22, 95% CI = 1.05-1.41; dominant: FEM: OR = 1.23, 95% CI = 1.03-1.46. No evidence indicated an association between rs2030324 with AD in codominant (random-effects model (REM: OR = 1.06, 95% CI = 0.89-1.26 and dominant (REM: OR = 1.05, 95% CI = 0.86-1.27 models. CONCLUSION: This meta-analysis suggested A allele of rs6265 might increase the risk of AD in Caucasian females and female LOAD patients. In addition, no evidence indicated an association between rs2030324 with AD. Further studies are needed to confirm these results.
Lee, Sung Won; Lee, Shin Seok; Oh, Dong Ho; Park, Dong Jin; Kim, Hyun Sook; Choi, Jung Ran; Chae, Soo Cheon; Yun, Ki Jung; Chung, Won Tae; Choe, Jung Yoon; Kim, Seong Kyu
2016-10-01
The aim of this study was to determine the association between P2X7R rs3751142 and CARD8 rs2043211 polymorphisms and gout susceptibility in male Korean subjects. This study enrolled a total of 242 male patients with gout and 280 healthy controls. The polymorphisms of two individual genes including rs3751142(C>A) in the P2X7R gene and rs2043211(A>T) in the CARD8 gene were assessed using Taq-Man analysis. Statistical analyses were performed using the Chi-square test, Kruskal-Wallis test, and logistic regression analyses. A difference in genotypic frequency of the P2X7R rs3751142 and CARD8 rs2043211 genes was not detected between gout and control patients. Clinical parameters including age, onset age, disease duration, body mass index, and serum uric acid levels were not different among the three genotypes for either P2X7R or CARD8 (P > 0.05 for all). A pair-wise comparison of P2X7R rs3751142 and CARD8 rs2043211 genotype combinations revealed that subjects with the CA P2X7R rs3751142 genotype and the TT CARD8 rs2043211 genotype had a trend toward a higher risk of gout compared to the CC/AA combination (P = 0.056, OR = 2.618, 95% CI 0.975 - 7.031). In conclusion, this study revealed that genetic variability of the P2X7R rs3751142 and CARD8 rs2043211 genes might, in part, be associated with susceptibility for gout.
Design Report for Isolated RS-485 Bus Node
2016-07-01
TERMS Android , RS-485, isolated, USB, smartphone 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18. NUMBER...controlled wired RS-485 network. The Android -based smartphone or tablet is used in conjunction with a USB to serial bridge to operate as the bus master in...the system. The Android device operates in USB Host mode and communicates to the RS-485 bus as if a single peripheral on the USB bus. 15. SUBJECT
The international thermonuclear experimental reactor and the future of nuclear fusion energy
International Nuclear Information System (INIS)
Pan Chuanhong
2010-01-01
Energy shortage and environmental problems are now the two largest challenges for human beings. Magnetic confinement nuclear fusion, which has achieved great progress since the 1990's, is anticipated to be a way to realize an ideal source of energy in the future because of its abundance, environmental compatibility, and zero carbon release. Exemplified by the construction of the International Thermonuclear Experimental Reactor (ITER), the development of nuclear fusion energy is now in its engineering phase, and should be realized by the middle of this century if all objectives of the ITER project are met. (author)
International Nuclear Information System (INIS)
Dang, V.D.; Steinberg, M.; Lazareth, O.W.; Powell, J.R.
1976-05-01
The formation of ozone from oxygen and the dissociation carbon dioxide to carbon monoxide and oxygen is studied in a gamma-neutron chemical process blanket associated with a controlled thermonuclear reactor. Materials used for reactor tube wall will affect the efficiency of the energy absorption by the reactants and consequently the yield of reaction products. Three kinds of materials, aluminum, stainless steel and fiber (Al 2 O 3 )-aluminium are investigated for the tube wall material in the study
RS485 optical router for HIRFL-CSR
International Nuclear Information System (INIS)
Zhang Shuocheng; Wang Dan; Jing Lan; Qiao Weimin
2007-01-01
A communication equipment-RS485 optical router has been developed to satisfy requirements of control system communication network of HIRFL-CSR (Heavy Ion Research Facility at Lanzhou-Cooling Storage Ring). The equipment is compatible with multiple communication protocols, such as Ethernet, RS232 and RS485 standard. It can be used to setup the RS485 communication network quickly and connected to the Ethernet easily. The fiber optical interface is introduced to facilitate the connection with the network of industrial Fiber Optics Communication (FOC), which expands the application field of the equipment in a large extent. This paper introduces the details of the equipment, including the design of the circuit and software, features of the equipment and how it works in the whole control system network. Its application in the HIRFL-CSR control system shows that the equipment is in accordance with the general requirement of automatic control communication system. It could also be used in other industrial automatic control fields. (authors)
Synthetic report 2012. Research programme on controlled thermonuclear fusion
International Nuclear Information System (INIS)
Vaucher, C.; Tran, M. Q.; Villard, L.; Marot, L.
2013-01-01
Since 1961, Switzerland participates in the research on thermonuclear fusion thanks to the creation of the Research Centre in Plasma Physics. In 1979 it entered into partnership with the European programme on fusion through its adhesion to EURATOM. The thermonuclear fusion is an interesting energy source because the basic fuel is practically inexhaustible and its use does not release any significant CO 2 quantity and very little radioactive residues. But its working up faces enormous physical and technological difficulties. The International Thermonuclear Reactor (ITER), presently in construction, has to demonstrate the technological feasibility of the controlled fusion. Il will be followed by DEMO, foreseen for 2040-2050, which must guarantee the economical rentability. At CRPP the research projects are partitioned onto several sites: at the Swiss Federal Institute of Technology (EPFL) in Lausanne, they concern the physics of the magnetic confinement with the Variable Geometry Tokamak (TCV), the development of theoretical models and the numerical simulation, the plasma heating and the generation of hyper frequency waves; the Paul Scherrer Institute (PSI) studies the superconductivity and the materials; the interactions between the plasma and the Tokamak walls are studied at the Basel University for the structures of ITER. Thanks to its large flexibility, TCV allows the creation and the control of plasmas of very different forms. The injection system of millimetric waves allows orienting the injected power according to specific profiles. By using the asymmetry of the flow in the toroidal sense, the plasma rotation could be measured with a much better accuracy than before. In TCV, by playing on the form of the plasma, it was possible to strongly reduce the energy quantity which is expelled by the Edge Localized Modes (ELM) onto the wall of the vacuum chamber. The ‘snowflake’ configuration created in TCV allows distributing the ELM energy onto several impact
Volobaev, Valentin P; Larionov, Aleksey V; Kalyuzhnaya, Ekaterina E; Serdyukova, Ekaterina S; Yakovleva, Svetlana; Druzhinin, Vladimir G; Babich, Olga O; Hill, Elena G; Semenihin, Victor A; Panev, Nikolay I; Minina, Varvara I; Sivanesan, Saravana Devi; Naoghare, Pravin; da Silva, Juliana; Barcelos, Gustavo R M; Prosekov, Alexander Y
2018-04-13
Anthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with АS. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1β T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI}, 3.29-4.10) and 0.28 (95% CI, 0.17-0.38)] compared to the control group [2.41 (95% CI, 2.00-2.82) and 0.09 (95% CI, 0.03-0.15)], respectively. IL1β gene T/T genotype (rs16944) was associated with AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88-12.15), P < 0.01]. A significant increase in the level of certain chromosome interchanges among AS donors is of interest because such effects are typical for radiation damage and caused by acute oxidative stress. IL1β T allele probably may be considered as an AS susceptibility factor among coal miners.
Multirate Filter Bank Representations of RS and BCH Codes
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Van Meerbergen Geert
2008-01-01
Full Text Available Abstract This paper addresses the use of multirate filter banks in the context of error-correction coding. An in-depth study of these filter banks is presented, motivated by earlier results and applications based on the filter bank representation of Reed-Solomon (RS codes, such as Soft-In Soft-Out RS-decoding or RS-OFDM. The specific structure of the filter banks (critical subsampling is an important aspect in these applications. The goal of the paper is twofold. First, the filter bank representation of RS codes is now explained based on polynomial descriptions. This approach allows us to gain new insight in the correspondence between RS codes and filter banks. More specifically, it allows us to show that the inherent periodically time-varying character of a critically subsampled filter bank matches remarkably well with the cyclic properties of RS codes. Secondly, an extension of these techniques toward the more general class of BCH codes is presented. It is demonstrated that a BCH code can be decomposed into a sum of critically subsampled filter banks.
Multirate Filter Bank Representations of RS and BCH Codes
Directory of Open Access Journals (Sweden)
Marc Moonen
2009-01-01
Full Text Available This paper addresses the use of multirate filter banks in the context of error-correction coding. An in-depth study of these filter banks is presented, motivated by earlier results and applications based on the filter bank representation of Reed-Solomon (RS codes, such as Soft-In Soft-Out RS-decoding or RS-OFDM. The specific structure of the filter banks (critical subsampling is an important aspect in these applications. The goal of the paper is twofold. First, the filter bank representation of RS codes is now explained based on polynomial descriptions. This approach allows us to gain new insight in the correspondence between RS codes and filter banks. More specifically, it allows us to show that the inherent periodically time-varying character of a critically subsampled filter bank matches remarkably well with the cyclic properties of RS codes. Secondly, an extension of these techniques toward the more general class of BCH codes is presented. It is demonstrated that a BCH code can be decomposed into a sum of critically subsampled filter banks.
Helical type thermonuclear device and control method
International Nuclear Information System (INIS)
Ishigaki, Yukio.
1990-01-01
In a conventional helical type thermonuclear device, electric current flows in the toroidal direction under magnetic fields of helical coils and vertical magnetic coils, by which a circulating electric field is caused. Therefore, there is a problem that electrons as a seed are generated by cosmic rays, etc., the electrons are confined in a magnetic field boundary, are accelerated by the circulating electric field, to reach a high energy level, collide against structures in a vacuum vessel and emit a great amount of X-rays. Then, compensation coils for offsetting the magnetic fields generated upon energization and deenergization of the vertical magnetic coils and the power source therefor are disposed at the positions opposing to each other on both sides of the vertical magnetic coils for controlling the variation coefficient rate of electric current upon energization and deenergization of the vertical magnetic coils. Since the compensation coils also offset the magnetic field generated upon energization and deenergization of the vertical magnetic field coils by this control, the circulating magnetic field is not caused in the vacuum vessel to reduce the X-ray radiation by electrons at high energy level. (N.H.)
Operating large controlled thermonuclear fusion research facilities
International Nuclear Information System (INIS)
Gaudreau, M.P.J.; Tarrh, J.M.; Post, R.S.; Thomas, P.
1987-10-01
The MIT Tara Tandem Mirror is a large, state of the art controlled thermonuclear fusion research facility. Over the six years of its design, implementation, and operation, every effort was made to minimize cost and maximize performance by using the best and latest hardware, software, and scientific and operational techniques. After reviewing all major DOE fusion facilities, an independent DOE review committee concluded that the Tara operation was the most automated and efficient of all DOE facilities. This paper includes a review of the key elements of the Tara design, construction, operation, management, physics milestones, and funding that led to this success. We emphasize a chronological description of how the system evolved from the proposal stage to a mature device with an emphasis on the basic philosophies behind the implementation process. This description can serve both as a qualitative and quantitative database for future large experiment planning. It includes actual final costs and manpower spent as well as actual run and maintenance schedules, number of data shots, major system failures, etc. The paper concludes with recommendations for the next generation of facilities. 13 refs., 15 figs., 3 tabs
Directory of Open Access Journals (Sweden)
Lucia Vernerova
Full Text Available The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA and redundancy analysis (RDA.A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601, STAT4 G/T (rs7574865, CTLA4 A/G (rs3087243, TRAF1/C5 A/G (rs3761847, IRF5 T/C (rs10488631, TNFAIP3 C/T (rs5029937, AFF3 A/T (rs11676922, PADI4 C/T (rs2240340, CD28 T/C (rs1980422, CSK G/A (rs34933034 and FCGR3A A/C (rs396991, rheumatoid factor (RF, anti-citrullinated protein antibodies (ACPA and clinical status was analysed using the LDA and RDA.HLA-DRB1, PTPN22, STAT4, IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. The correlation between RA diagnosis and the explanatory variables in the model was 0.328 (Trace = 0.107; F = 13.715; P = 0.0002. The risk variants of IRF5 and CD28 genes were found to be common determinants for seropositivity in RDA, while positivity of RF alone was associated with the CTLA4 risk variant in heterozygous form. The correlation between serologic status and genetic determinants on the 1st ordinal axis was 0.468, and 0.145 on the 2nd one (Trace = 0.179; F = 6.135; P = 0.001. The risk alleles in AFF3 gene together with the presence of ACPA were associated with higher clinical severity of RA.The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.
Vernerova, Lucia; Spoutil, Frantisek; Vlcek, Miroslav; Krskova, Katarina; Penesova, Adela; Meskova, Milada; Marko, Andrea; Raslova, Katarina; Vohnout, Branislav; Rovensky, Jozef; Killinger, Zdenko; Jochmanova, Ivana; Lazurova, Ivica; Steiner, Guenter; Smolen, Josef; Imrich, Richard
2016-01-01
The aim of the study was to analyse genetic architecture of RA by utilizing multiparametric statistical methods such as linear discriminant analysis (LDA) and redundancy analysis (RDA). A total of 1393 volunteers, 499 patients with RA and 894 healthy controls were included in the study. The presence of shared epitope (SE) in HLA-DRB1 and 11 SNPs (PTPN22 C/T (rs2476601), STAT4 G/T (rs7574865), CTLA4 A/G (rs3087243), TRAF1/C5 A/G (rs3761847), IRF5 T/C (rs10488631), TNFAIP3 C/T (rs5029937), AFF3 A/T (rs11676922), PADI4 C/T (rs2240340), CD28 T/C (rs1980422), CSK G/A (rs34933034) and FCGR3A A/C (rs396991), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and clinical status was analysed using the LDA and RDA. HLA-DRB1, PTPN22, STAT4, IRF5 and PADI4 significantly discriminated between RA patients and healthy controls in LDA. The correlation between RA diagnosis and the explanatory variables in the model was 0.328 (Trace = 0.107; F = 13.715; P = 0.0002). The risk variants of IRF5 and CD28 genes were found to be common determinants for seropositivity in RDA, while positivity of RF alone was associated with the CTLA4 risk variant in heterozygous form. The correlation between serologic status and genetic determinants on the 1st ordinal axis was 0.468, and 0.145 on the 2nd one (Trace = 0.179; F = 6.135; P = 0.001). The risk alleles in AFF3 gene together with the presence of ACPA were associated with higher clinical severity of RA. The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.
Review of the International Thermonuclear Experimental Reactor (ITER) detailed design report
International Nuclear Information System (INIS)
1997-01-01
Dr. Martha Krebs, Director, Office of Energy Research at the US Department of Energy (DOE), wrote to the Fusion Energy Sciences Advisory Committee (FESAC), in letters dated September 23 and November 6, 1996, requesting that FESAC review the International Thermonuclear Experimental Reactor (ITER) Detailed Design Report (DDR) and provide its view of the adequacy of the DDR as part of the basis for the United States decision to enter negotiations with the other interested Parties regarding the terms and conditions for an agreement for the construction, operations, exploitation and decommissioning of ITER. The letter from Dr. Krebs, referred to as the Charge Letter, provided context for the review and a set of questions of specific interest
Review of the International Thermonuclear Experimental Reactor (ITER) detailed design report
Energy Technology Data Exchange (ETDEWEB)
NONE
1997-04-18
Dr. Martha Krebs, Director, Office of Energy Research at the US Department of Energy (DOE), wrote to the Fusion Energy Sciences Advisory Committee (FESAC), in letters dated September 23 and November 6, 1996, requesting that FESAC review the International Thermonuclear Experimental Reactor (ITER) Detailed Design Report (DDR) and provide its view of the adequacy of the DDR as part of the basis for the United States decision to enter negotiations with the other interested Parties regarding the terms and conditions for an agreement for the construction, operations, exploitation and decommissioning of ITER. The letter from Dr. Krebs, referred to as the Charge Letter, provided context for the review and a set of questions of specific interest.
Pulsating Instability of Turbulent Thermonuclear Flames in Type Ia Supernovae
Poludnenko, Alexei Y.
2014-01-01
Presently, one of the main explosion scenarios of type Ia supernovae (SNIa), aimed at explaining both "normal" and subluminous events, is the thermonuclear incineration of a white-dwarf in a single-degenerate system. The underlying engine of such explosions is the turbulent thermonuclear flame. Modern, large-scale, multidimensional simulations of SNIa cannot resolve the internal flame structure, and instead must include a subgrid-scale prescription for the turbulent-flame properties. As a result, development of robust, parameter-free, large-scale models of SNIa crucially relies on the detailed understanding of the turbulent flame properties during each stage of the flame evolution. Due to the complexity of the flame dynamics, such understanding must be validated by the first-principles direct numerical simulations (DNS). In our previous work, we showed that sufficiently fast turbulent flames are inherently susceptible to the development of detonations, which may provide the mechanism for the deflagration-to-detonation transition (DDT) in the delayed-detonation model of SNIa. Here we extend this study by performing detailed analysis of the turbulent flame properties at turbulent intensities below the critical threshold for DDT. We carried out a suite of 3D DNS of turbulent flames for a broad range of turbulent intensities and system sizes using a simplified, single-step, Arrhenius-type reaction kinetics. Our results show that at the later stages of the explosion, as the turbulence intensity increases prior to the possible onset of DDT, the flame front will become violently unstable. We find that the burning rate exhibits periodic pulsations with the energy release rate varying by almost an order of magnitude. Furthermore, such flame pulsations can produce pressure waves and shocks as the flame speed approaches the critical Chapman-Jouguet deflagration speed. Finally, in contrast with the current theoretical understanding, such fast turbulent flames can propagate at
Demonstration of thermonuclear conditions in magnetized liner inertial fusion experiments
International Nuclear Information System (INIS)
Gomez, M. R.; Slutz, S. A.; Sefkow, A. B.; Hahn, K. D.; Hansen, S. B.; Knapp, P. F.; Schmit, P. F.; Ruiz, C. L.; Sinars, D. B.; Harding, E. C.; Jennings, C. A.; Awe, T. J.; Geissel, M.; Rovang, D. C.; Smith, I. C.; Chandler, G. A.; Cooper, G. W.; Cuneo, M. E.; Harvey-Thompson, A. J.; Hess, M. H.
2015-01-01
The magnetized liner inertial fusion concept [S. A. Slutz et al., Phys. Plasmas 17, 056303 (2010)] utilizes a magnetic field and laser heating to relax the pressure requirements of inertial confinement fusion. The first experiments to test the concept [M. R. Gomez et al., Phys. Rev. Lett. 113, 155003 (2014)] were conducted utilizing the 19 MA, 100 ns Z machine, the 2.5 kJ, 1 TW Z Beamlet laser, and the 10 T Applied B-field on Z system. Despite an estimated implosion velocity of only 70 km/s in these experiments, electron and ion temperatures at stagnation were as high as 3 keV, and thermonuclear deuterium-deuterium neutron yields up to 2 × 10 12 have been produced. X-ray emission from the fuel at stagnation had widths ranging from 50 to 110 μm over a roughly 80% of the axial extent of the target (6–8 mm) and lasted approximately 2 ns. X-ray yields from these experiments are consistent with a stagnation density of the hot fuel equal to 0.2–0.4 g/cm 3 . In these experiments, up to 5 × 10 10 secondary deuterium-tritium neutrons were produced. Given that the areal density of the plasma was approximately 1–2 mg/cm 2 , this indicates the stagnation plasma was significantly magnetized, which is consistent with the anisotropy observed in the deuterium-tritium neutron spectra. Control experiments where the laser and/or magnetic field were not utilized failed to produce stagnation temperatures greater than 1 keV and primary deuterium-deuterium yields greater than 10 10 . An additional control experiment where the fuel contained a sufficient dopant fraction to substantially increase radiative losses also failed to produce a relevant stagnation temperature. The results of these experiments are consistent with a thermonuclear neutron source
International Nuclear Information System (INIS)
Ludwig, Gerson Otto
2002-01-01
The year 2001 activities of the controlled thermonuclear fusion research line of the Plasma Associated Laboratory at the National Institute for Space Research - Brazil are reported. The report approaches the staff, participation in congresses, goals for the year 2002 and papers on Tokamak plasmas, plasma diagnostic, bootstraps, plasma equilibrium and diagnostic
Dai, Yu; Zeng, Tianshu; Xiao, Fei; Chen, Lulu; Kong, Wen
2017-01-01
We conducted a case/control study to assess the impact of SNP rs3087243 and rs231775 within the CTLA4 gene, on the susceptibility to Graves' disease (GD) in a Chinese Han dataset (271 cases and 298 controls). The frequency of G allele for rs3087243 and rs231775 was observed to be significantly higher in subjects with GD than in control subjects (p = 0.005 and p = 0.000, respectively). After logistic regression analysis, a significant association was detected between SNP rs3087243 and GD in the additive and recessive models. Similarly, association for the SNP rs231775 could also be detected in the additive model, dominant model and recessive model. A meta-analysis, including 27 published datasets along with the current dataset, was performed to further confirm the association. Consistent with our case/control results, rs3087243 and rs231775 showed a significant association with GD in all genetic models. Of note, ethnic stratification revealed that these two SNPs were associated with susceptibility to GD in populations of both Asian and European descent. In conclusion, our data support that the rs3087243 and rs231775 polymorphisms within the CTLA4 gene confer genetic susceptibility to GD. PMID:29299173
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Edhit Guadalupe Cruz Quevedo
2015-01-01
Full Text Available Aims. KiSS1 is a metastasis suppressor gene associated with inhibition of cellular chemotaxis and invasion attenuating the metastasis in melanoma and breast cancer cell lines. Along the KiSS-1 gene at least 294 SNPs have been described; however the association of these polymorphisms as genetic markers for metastasis in breast cancer studies has not been investigated. Here we describe two simple PCR-RFLPs protocols to identify the rs5780218 (9DelT and the rs12998 (E20K KiSS1 polymorphisms and the allelic, genotypic, and haplotypic frequencies in Mexican general population (GP and patients with benign breast disease (BBD or breast cancer (BC. Results. The rs5780218 polymorphism was individually associated with breast cancer (P=0.0332 and the rs12998 polymorphism shows statistically significant differences when GP versus case (BC and BBD groups were compared (P<0.0001. The H1 Haplotype (G/- occurred more frequently in BC group (0.4256 whereas H2 haplotype (G/T was the most prevalent in BBD group (0.4674. Conclusions. Our data indicated that the rs5780218 polymorphism individually confers susceptibility for development of breast cancer in Mexican population and a possible role as a genetic marker in breast cancer metastasis for H1 haplotype (Wt/variant in KiSS1 gene must be analyzed in other populations.
International Nuclear Information System (INIS)
Starrfield, S.; Kenyon, S.; Truran, J.W.; Sparks, W.M.
1983-01-01
We have used a Lagrangian, hydrodynamic stellar-evolution computer code to evolve a thermonuclear runaway in the accreted hydrogen rich envelope of a 1.0M, 10-km neutron star. Our simulation produced an outburst which lasted about 2000 sec and peak effective temperature was 3 keV. The peak luminosity exceeded 2 x 10 5 L. A shock wave caused a precursor in the light curve which lasted 10 -5 sec
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Rotter I
2016-11-01
Full Text Available Iwona Rotter,1 Karolina Skonieczna-Żydecka,2 Danuta Kosik-Bogacka,3 Grażyna Adler,2 Aleksandra Rył,4 Maria Laszczyńska4 1Department of Medical Rehabilitation, 2Department of Gerontobiology, 3Department of Biology and Medical Parasitology, 4Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland Purpose: Metabolic disorders, including MetS, obesity, and lipid disorders, may be related to genetic factors. Metabolic disorders are associated with decreased TS levels in aging men. The aim of this study was to evaluate the relationship between FTO rs9939609, MC4R rs17782313, and PPARɣ rs1801282 polymorphisms and the presence of MetS and its components, the concurrent lipid disorders, as well as sex hormone concentrations. Subjects and methods: This study involved 272 men of Caucasian descent aged 50–75 years. Lipid profile, including TCh, LDL, HDL, and TG, was evaluated by spectrophotometric method. Anthropometric measurements concerned WC and blood pressure. MetS was diagnosed according to the criteria of the IDF. Sex hormone profile, including TST, FTS, E2, DHEAS, and SHBG, was examined using enzyme-linked immunosorbent assay. Polymorphisms within FTO, MC4R, and PPARɣ genes were identified using polymerase chain reaction-restriction fragments length polymorphism. Results: This study did not show links between the analyzed genetic polymorphisms and the presence of MetS, T2DM, HT, and obesity. However, higher concentrations of TCh and LDL were found in men with the FTO rs9939609 polymorphism in the recessive mode of inheritance (P=0.03 and P=0.05, respectively. Lower WC was found to be associated with MC4R rs17782313 gene inherited in the same model (P=0.005. Conclusion: FTO rs9939609, MC4R rs17782313, and PPARɣ rs1801282 polymorphisms seem to have little effect on the incidence of metabolic malfunctions and no effect on androgen-related disorders in the examined middle-aged and elderly men
X-ray sources in stars formation areas: T Tauri stars and proto-stars in the rho Ophiuchi dark cloud
International Nuclear Information System (INIS)
Grosso, Nicolas
1999-01-01
This thesis studies from large to small scales, X-ray sources in the rho Ophiuchi dark cloud. After some background on the formation of the low-mass young stars (Chapter 1), Chapter 2 takes an interest in the T Tauri star population. Chapter 3 tackles the search of the magnetic activity at the younger stage of protostar, presenting a powerful X-ray emission from an IR protostar, called YLW15, during a flare, and a quasi-periodic flare of the same source; as well as a new detection of another IR protostar in the ROSAT archives. It ends with a review of protostar detections. Some IR protostar flares show a very long increasing phase. Chapter 4 links this behaviour with a modulation by the central star rotation. The standard model of jet emission assumes that the central star rotates at the same speed that the inner edge of its accretion disk. This chapter shows that the observation of the YLW15 quasi-periodic flare suggests rather that the forming star rotates faster than its accretion disk, at the break up limit. The synchronism with the accretion disk, observed on T Tauri stars, must be reach progressively by magnetic breaking during the IR protostar stage, and more or less rapidly depending on the forming star mass. Recent studies have shown that T Tauri star X-ray emission could ionize the circumstellar disk, and play a role in the instability development, as well as stimulate the accretion. The protostar X-ray emission might be higher than the T Tauri star one, Chapter 5 presents a millimetric interferometric observation dedicated to measure this effect on YLW15. Finally, Chapter 6 reassembles conclusions and perspectives of this work. (author) [fr
Method for baking a liner in thermonuclear device
International Nuclear Information System (INIS)
Yamamoto, Keiichi.
1978-01-01
Purpose: To attain effective baking for liners in a tokamak device by connecting the narrow portions and the wide portions of the liners with dielectric materials and supplying a constant current to these portions. Method: Split type liners disposed in the vacuum vessel of a thermonuclear device are connected with dielectric materials at their wide portions and narrow portions and they are baked by supplying a constant current at a same density to the wide and narrow portions to rise their temperature uniformly. The wide portions are formed in such a way that the sum of their cross sectional areas is equal to the sum of the cross sectional areas of the narrow portions, and they form a parallel circuit. The parallel circuit consisting of the wide portions and the parallel circuit consisting of the narrow portions are connected in series to each other and connected to the constant current supply circuit, by which a constant current is supplied to the wide and the narrow portions. (Moriyama, K.)
Focused Study of Thermonuclear Bursts on Neutron Stars
Chenevez, Jérôme
2009-05-01
X-ray bursters form a class of Low Mass X-Ray Binaries where accreted material from a donor star undergoes rapid thermonuclear burning in the surface layers of a neutron star. The flux released can temporarily exceed the Eddington limit and drive the photosphere to large radii. Such photospheric radius expansion bursts likely eject nuclear burning ashes into the interstellar medium, and may make possible the detection of photoionization edges. Indeed, theoretical models predict that absorption edges from 58Fe at 9.2 keV, 60Zn and 62Zn at 12.2 keV should be detectable by the future missions Simbol-X and NuSTAR. A positive detection would thus probe the nuclear burning as well as the gravitational redshift from the neutron star. Moreover, likely observations of atomic X-ray spectral components reflected from the inner accretion disk have been reported. The high spectral resolution capabilities of the focusing X-ray telescopes may therefore make possible to differentiate between the potential interpretations of the X-ray bursts spectral features.
Fan, Zhi-Dan; Wang, Fei-Fei; Huang, Hui; Huang, Na; Ma, Hui-Hui; Guo, Yi-Hong; Zhang, Ya-Yuan; Qian, Xiao-Qing; Yu, Hai-Guo
2015-01-01
Juvenile idiopathic arthritis (JIA) is a common autoimmune disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The protein tyrosine phosphatase nonreceptor 22 (PTPN22) and signal transducer and activator of transcription factor 4 (STAT4) have been recognized as susceptibility genes for numerous autoimmune diseases. Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T) polymorphisms with JIA have repeatedly been replicated in several Caucasian populations. The aim of this study was to investigate the influence of three polymorphisms mentioned above on the risk of developing JIA in Han Chinese patients. Genotyping was performed on a total of 137 Chinese patients with JIA (JIA group) and 150 sex and age frequency-matched healthy volunteers (Control group). The single-nucleotide polymorphisms (SNP) were determined by using direct sequencing of PCR-amplified products. There were significant differences of PTPN22 rs2488457 G/C and STAT4 rs7574865 G/T polymorphisms between both groups. However, no significant difference was observed in distribution frequencies of PTPN22 rs2476601 polymorphism. The association with the PTPN22 rs2488457 G/C polymorphism remained significant in the stratifications by age at onset, ANA status, splenomegaly, lymphadenectasis and involvement joints. As with the STAT4 rs7574865 G/T polymorphisms, the enthesitis-related arthritis and presence of hepatomegaly had strong effect on the association. Our data strengthen STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms as susceptibility factors for JIA.
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Zhi-Dan Fan
Full Text Available Juvenile idiopathic arthritis (JIA is a common autoimmune disease characterized by environmental influences along with several predisposing genes in the pathogenesis. The protein tyrosine phosphatase nonreceptor 22 (PTPN22 and signal transducer and activator of transcription factor 4 (STAT4 have been recognized as susceptibility genes for numerous autoimmune diseases. Associations of STAT4 rs7574865 G/T and PTPN22 (rs2488457 G/C and rs2476601 C/T polymorphisms with JIA have repeatedly been replicated in several Caucasian populations. The aim of this study was to investigate the influence of three polymorphisms mentioned above on the risk of developing JIA in Han Chinese patients. Genotyping was performed on a total of 137 Chinese patients with JIA (JIA group and 150 sex and age frequency-matched healthy volunteers (Control group. The single-nucleotide polymorphisms (SNP were determined by using direct sequencing of PCR-amplified products. There were significant differences of PTPN22 rs2488457 G/C and STAT4 rs7574865 G/T polymorphisms between both groups. However, no significant difference was observed in distribution frequencies of PTPN22 rs2476601 polymorphism. The association with the PTPN22 rs2488457 G/C polymorphism remained significant in the stratifications by age at onset, ANA status, splenomegaly, lymphadenectasis and involvement joints. As with the STAT4 rs7574865 G/T polymorphisms, the enthesitis-related arthritis and presence of hepatomegaly had strong effect on the association. Our data strengthen STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms as susceptibility factors for JIA.
Sepahi, Neda; Kohan, Leila; Jahromi, Athar Rasekh; Daneshbod, Yahya; Hoveidi, Elahe Nimi
2017-06-01
microRNAs (miRNAs) are negative regulators in a variety of cellular processes that occur in endometriosis. Therefore, functional polymorphisms in miRNA and miRNA binding sites may affect gene expression and contribute to susceptibility of endometriosis. In this study, we evaluated the association of two miRNA related polymorphisms, mir-126 rs4636297 and TGFβRI rs334348, with endometriosis risk and its severity. This case-control study was done on 157 endometriosis patients and 252 healthy women as a control group. Tetra amplification refractory mutation system-polymerase chain reaction (tetra-ARMS PCR) was designed to determine the polymorphisms. Our finding showed significant differences in genotype frequency of mir-126 rs4636297 between the groups (χ 2 = 6.26, p = 0.044). A significant protection against endometriosis was found for mir-126 rs4636297 in allele (G versus A allele: OR = 0.695, 95% CI = 0.519-0.931, p = 0.015) and genotype (GG versus AA genotype: OR = 0.451, 95%CI = 0.233-0.873, p = 0.018). Significant association was also observed between the A allele and severity of endometriosis (OR = 0.478, 95%CI = 0.297-0.768, p = 0.002). Moreover, we found a significant association between AA genotype with the risk of endometriosis (OR = 0.493, 95%CI = 0.250-0.970, p = 0.041) and its severity (OR = 0.240, 95%CI = 0.065-0.883, p = 0.032) regarding TGFβRI rs334348 polymorphism. These finding suggest that, for the first time, mir-126 rs4636297 and TGFβRI rs334348 polymorphisms may influence individual's susceptibility to endometriosis and its severity.
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Piotr Janik
Full Text Available Gilles de la Tourette syndrome (GTS is a neurodevelopmental disorder characterized by motor and vocal tics. Hyperactivity of dopaminergic transmission is considered a prime abnormality in the pathophysiology of tics. There are reciprocal antagonistic interactions between adenosine and dopamine transmission. The aim of the study was to analyze the association of two polymorphisms, rs2228079 in ADORA1 and rs5751876 in ADORA2A, with the risk of GTS and co-morbid disorders.A total of 162 Polish GTS patients and 270 healthy persons were enrolled in the study. Two polymorphisms were selected on the basis of knowledge of SNPs frequencies in ADORA1 and ADORA2A. Chi-square test was used for allelic and genotypic association studies. Association of genotypes with age of tic onset was analyzed with Mann-Whitney test. Multivariate logistic regression was used to find independent predictors of GTS risk.We found that the risk of GTS was associated with rs2228079 and rs5751876 polymorphisms. The GG+GT genotypes of rs2228079 in ADORA1 were underrepresented in GTS patients (p = 0.011, whereas T allele of rs5751876 in ADORA2A was overrepresented (p = 0.017. The GG genotype of rs2228079 was associated with earlier age of tic onset (p = 0.046. We found also that the minor allele G of rs2228079 was more frequent in GTS patients with depression as compared to the patients without depression (p = 0.015. Also the genotype GG was significantly more frequent in patients with obsessive compulsive disorder/behavior (OCD/OCB, p = 0.021 and depression (p = 0.032, as compared to the patients without these co-morbidities. The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022, and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045.ADORA1 and ADORA2A variants are associated with the risk of GTS, co-morbid disorders, and may affect the age of tic onset.
International Nuclear Information System (INIS)
Archer, J.; Stalport, G.; Besson, D.; Faron, R.; Coulon, M.
1988-01-01
The cooling device for a thermonuclear reactor wall is made by modular thermally conductive heat-resistant blocks (graphite by example), a prismatic head on one face of each block, the opposite face bearing against cooling tubes, a base to each block with an aperture and rods passing through the apertures reversibly fixing each row of blocks to a support [fr
Vacuum vessel of thermonuclear device and manufacturing method thereof
International Nuclear Information System (INIS)
Kurita, Genichi; Nagashima, Keisuke; Uchida, Takaho; Shibui, Masanao; Ebisawa, Katsuyuki; Nakagawa, Satoshi.
1997-01-01
The present invention provides a vacuum vessel of a thermonuclear device using, as a material of a plasma vacuum vessel, a material to be less activated and having excellent strength as well as a manufacturing method thereof. Namely, the vacuum vessel is made of titanium or a titanium alloy. In addition, a liner layer comprising a manganese alloy, nickel alloy, nickel-chromium alloy or aluminum or aluminum alloy is formed. With such a constitution, the wall substrate made of titanium or a titanium alloy can be isolated by the liner from hydrogen or plasmas. As a result, occlusion of hydrogen to titanium or the titanium alloy can be prevented thereby enabling to prevent degradation of the material of the wall substrate of the vacuum vessel. In addition, since the liner layer has relatively high electric resistance, a torus circumferential resistance value required for plasma ignition can be ensured by using it together with the vessel wall made of titanium alloy. (I.S.)
SPIRAL INSTABILITY CAN DRIVE THERMONUCLEAR EXPLOSIONS IN BINARY WHITE DWARF MERGERS
International Nuclear Information System (INIS)
Kashyap, Rahul; Fisher, Robert; García-Berro, Enrique; Aznar-Siguán, Gabriela; Ji, Suoqing; Lorén-Aguilar, Pablo
2015-01-01
Thermonuclear, or Type Ia supernovae (SNe Ia), originate from the explosion of carbon–oxygen white dwarfs, and serve as standardizable cosmological candles. However, despite their importance, the nature of the progenitor systems that give rise to SNe Ia has not been hitherto elucidated. Observational evidence favors the double-degenerate channel in which merging white dwarf binaries lead to SNe Ia. Furthermore, significant discrepancies exist between observations and theory, and to date, there has been no self-consistent merger model that yields a SNe Ia. Here we show that a spiral mode instability in the accretion disk formed during a binary white dwarf merger leads to a detonation on a dynamical timescale. This mechanism sheds light on how white dwarf mergers may frequently yield SNe Ia
SPIRAL INSTABILITY CAN DRIVE THERMONUCLEAR EXPLOSIONS IN BINARY WHITE DWARF MERGERS
Energy Technology Data Exchange (ETDEWEB)
Kashyap, Rahul; Fisher, Robert [Department of Physics, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02740 (United States); García-Berro, Enrique; Aznar-Siguán, Gabriela [Departament de Física Aplicada, Universitat Politècnica de Catalunya, c/Esteve Terrades, 5, E-08860 Castelldefels (Spain); Ji, Suoqing [Department of Physics, Broida Hall, University of California Santa Barbara, Santa Barbara, CA 93106–9530 (United States); Lorén-Aguilar, Pablo [School of Physics, University of Exeter, Stocker Road, Exeter EX4 4QL (United Kingdom)
2015-02-10
Thermonuclear, or Type Ia supernovae (SNe Ia), originate from the explosion of carbon–oxygen white dwarfs, and serve as standardizable cosmological candles. However, despite their importance, the nature of the progenitor systems that give rise to SNe Ia has not been hitherto elucidated. Observational evidence favors the double-degenerate channel in which merging white dwarf binaries lead to SNe Ia. Furthermore, significant discrepancies exist between observations and theory, and to date, there has been no self-consistent merger model that yields a SNe Ia. Here we show that a spiral mode instability in the accretion disk formed during a binary white dwarf merger leads to a detonation on a dynamical timescale. This mechanism sheds light on how white dwarf mergers may frequently yield SNe Ia.
Evidence for a link between atmospheric thermonuclear detonations and nitric acid.
Holdsworth, G
1986-12-11
Suitably located glacier cores, obtained from high-altitude, low-temperature sites, can reveal detailed information about atmospheric air chemistry at sub-annual resolution 1 . Such data may provide input to climate-change models, the study of acid precipitation patterns and many other phenomena. Here I present data from an ice core which show that during the era of intense atmospheric thermonuclear weapons testing (ATWT) a significant part of the nitrate content in the snow was modulated by the intensity of the nuclear detonations. The fixation of nitrogen by nuclear fireballs leads to NO x gases in the atmosphere 2 and ultimately to nitric acid in precipitation. At certain concentrations, these gases and the associated aerosols may perturb the climate 3,4 .
ITER [International Thermonuclear Experimental Reactor] shield and blanket work package report
International Nuclear Information System (INIS)
1988-06-01
This report summarizes nuclear-related work in support of the US effort for the International Thermonuclear Experimental Reactor (ITER) Study. The purpose of this work was to prepare for the first international ITER workshop devoted to defining a basic ITER concept that will serve as a basis for an indepth conceptual design activity over the next 2-1/2 years. Primary tasks carried out during the past year included: design improvements of the inboard shield developed for the TIBER concept, scoping studies of a variety of tritium breeding blanket options, development of necessary design guidelines and evaluation criteria for the blanket options, further safety considerations related to nuclear components and issues regarding structural materials for an ITER device. 44 refs., 31 figs., 29 tabs
Thermonuclear Reaction Rate Libraries and Software Tools for Nuclear Astrophysics Research
International Nuclear Information System (INIS)
Smith, Michael S.; Cyburt, Richard; Schatz, Hendrik; Smith, Karl; Warren, Scott; Ferguson, Ryan; Wiescher, Michael; Lingerfelt, Eric; Buckner, Kim; Nesaraja, Caroline D.
2008-01-01
Thermonuclear reaction rates are a crucial input for simulating a wide variety of astrophysical environments. A new collaboration has been formed to ensure that astrophysical modelers have access to reaction rates based on the most recent experimental and theoretical nuclear physics information. To reach this goal, a new version of the REACLIB library has been created by the Joint Institute for Nuclear Astrophysics (JINA), now available online at http://www.nscl.msu.edu/~nero/db. A complementary effort is the development of software tools in the Computational Infrastructure for Nuclear Astrophysics, online at nucastrodata.org, to streamline, manage, and access the workflow of the reaction evaluations from their initiation to peer review to incorporation into the library. Details of these new projects will be described
The optimal algorithm for Multi-source RS image fusion.
Fu, Wei; Huang, Shui-Guang; Li, Zeng-Shun; Shen, Hao; Li, Jun-Shuai; Wang, Peng-Yuan
2016-01-01
In order to solve the issue which the fusion rules cannot be self-adaptively adjusted by using available fusion methods according to the subsequent processing requirements of Remote Sensing (RS) image, this paper puts forward GSDA (genetic-iterative self-organizing data analysis algorithm) by integrating the merit of genetic arithmetic together with the advantage of iterative self-organizing data analysis algorithm for multi-source RS image fusion. The proposed algorithm considers the wavelet transform of the translation invariance as the model operator, also regards the contrast pyramid conversion as the observed operator. The algorithm then designs the objective function by taking use of the weighted sum of evaluation indices, and optimizes the objective function by employing GSDA so as to get a higher resolution of RS image. As discussed above, the bullet points of the text are summarized as follows.•The contribution proposes the iterative self-organizing data analysis algorithm for multi-source RS image fusion.•This article presents GSDA algorithm for the self-adaptively adjustment of the fusion rules.•This text comes up with the model operator and the observed operator as the fusion scheme of RS image based on GSDA. The proposed algorithm opens up a novel algorithmic pathway for multi-source RS image fusion by means of GSDA.
Quantitative evaluation of pairs and RS steganalysis
Ker, Andrew D.
2004-06-01
We give initial results from a new project which performs statistically accurate evaluation of the reliability of image steganalysis algorithms. The focus here is on the Pairs and RS methods, for detection of simple LSB steganography in grayscale bitmaps, due to Fridrich et al. Using libraries totalling around 30,000 images we have measured the performance of these methods and suggest changes which lead to significant improvements. Particular results from the project presented here include notes on the distribution of the RS statistic, the relative merits of different "masks" used in the RS algorithm, the effect on reliability when previously compressed cover images are used, and the effect of repeating steganalysis on the transposed image. We also discuss improvements to the Pairs algorithm, restricting it to spatially close pairs of pixels, which leads to a substantial performance improvement, even to the extent of surpassing the RS statistic which was previously thought superior for grayscale images. We also describe some of the questions for a general methodology of evaluation of steganalysis, and potential pitfalls caused by the differences between uncompressed, compressed, and resampled cover images.
The origin of the RS CVn binaries
International Nuclear Information System (INIS)
Biermann, P.
1976-01-01
Six possible origins for the RS CVn binaries are considered based on the following possibilities. RS CVn binaries might now be either pre-main-sequence or post-main-sequence. A pre-main-sequence binary might not always have been a binary but might have resulted from fission of a rapidly rotating single pre-main-sequence star. The main-sequence counterparts might be either single stars or binaries. To decide which of the six origins is possible, the following observed data for the RS CVn binaries are considered: total mass, total angular momentum, lack of observed connection with regions of star formation, large space density, kinematical age, and the visual companion of WW Dra. In addition lifetimes and space densities of single stars and other types of binaries are considered. The only origin possible is that the RS CVn binaries are in a thermal phase following fission of a main-sequence single star. In this explanation the single star had a rapidly rotating core which became unstable due to the core contraction which made it begin to evolve off the main sequence. The present Be stars might be examples of such parent single stars. (Auth.)
First implosion experiments with cryogenic thermonuclear fuel on the National Ignition Facility
International Nuclear Information System (INIS)
Glenzer, Siegfried H; Spears, Brian K; Edwards, M John; Berger, Richard L; Bleuel, Darren L; Bradley, David K; Caggiano, Joseph A; Callahan, Debra A; Castro, Carlos; Choate, Christine; Clark, Daniel S; Cerjan, Charles J; Collins, Gilbert W; Dewald, Eduard L; Di Nicola, Jean-Michel G; Di Nicola, Pascale; Divol, Laurent; Dixit, Shamasundar N; Alger, Ethan T; Casey, Daniel T
2012-01-01
Non-burning thermonuclear fuel implosion experiments have been fielded on the National Ignition Facility to assess progress toward ignition by indirect drive inertial confinement fusion. These experiments use cryogenic fuel ice layers, consisting of mixtures of tritium and deuterium with large amounts of hydrogen to control the neutron yield and to allow fielding of an extensive suite of optical, x-ray and nuclear diagnostics. The thermonuclear fuel layer is contained in a spherical plastic capsule that is fielded in the center of a cylindrical gold hohlraum. Heating the hohlraum with 1.3 MJ of energy delivered by 192 laser beams produces a soft x-ray drive spectrum with a radiation temperature of 300 eV. The radiation field produces an ablation pressure of 100 Mbar which compresses the capsule to a spherical dense fuel shell that contains a hot plasma core 80 µm in diameter. The implosion core is observed with x-ray imaging diagnostics that provide size, shape, the absolute x-ray emission along with bangtime and hot plasma lifetime. Nuclear measurements provide the 14.1 MeV neutron yield from fusion of deuterium and tritium nuclei along with down-scattered neutrons at energies of 10–12 MeV due to energy loss by scattering in the dense fuel that surrounds the central hot-spot plasma. Neutron time-of-flight spectra allow the inference of the ion temperature while gamma-ray measurements provide the duration of nuclear activity. The fusion yield from deuterium–tritium reactions scales with ion temperature, which is in agreement with modeling over more than one order of magnitude to a neutron yield in excess of 10 14 neutrons, indicating large confinement parameters on these first experiments. (paper)
Energy Technology Data Exchange (ETDEWEB)
Breton, D [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires
1958-07-01
The temperatures needed to produce thermonuclear reactions are of the order of several million degrees Kelvin. Devising methods for measuring such temperatures has been the subject of research in many countries. In order to present the problem clearly and to demonstrate its importance, the author reviews the various conditions which must be fulfilled in order that reactions may be qualified as thermonuclear. The relationship between the temperature and the cross-section of the reactions is studied, and it is shown that the notion of temperature in the plasmas is complex, which leads to a consideration of the temperature of the ions and that of the electrons. None of the methods for the temperature measurements is completely satisfactory because of the hypotheses which must be made, and which are seldom fulfilled during high-intensity discharges in the plasmas. In practice it is necessary to use several methods simultaneously. (author) [French] Les temperatures necessaires pour produire des reactions thermonucleaires sont de l'ordre de plusieurs millions de degres Kelvin. Les methodes envisagees pour mesurer ces temperatures font l'objet de recherches dans de nombreux pays. Afin de preciser le probleme et de montrer son importance, l'auteur rappelle les conditions qui doivent etre reunies pour que des reactions puissent etre qualifiees thermonucleaires. Il etudie la relation entre la temperature et la section efficace des reactions et montre que la notion de temperature dans les plasmas est complexe, ce qui amene a considerer la temperature des ions et celle des electrons. Aucune des methodes de mesure des temperatures n'est completement satisfaisante en raison des hypotheses qu'elles exigent et qui sont rarement realisees lors des decharges a haute intensite dans les plasmas. En pratique, il est necessaire d'utiliser plusieurs methodes simultanement. (auteur)
International Nuclear Information System (INIS)
Kaliski, S.
1979-01-01
An analysis is performed of the systems of an explosion-induced thermonuclear microfusion from the angle of attaining an internal break-even. A critical-state meter is defined, i.e. the critical neutron yield Nsub(cr) as the most convenient for characterizing the experimental setups. It is demonstrated that in a number of designed systems of an explosion-induced microfusion, Nsub(cr) is attained. In the experiments actually carried out the N-yield efficiency is of about three orders of magnitude. (author)
Belyaev, V. S.; Krainov, V. P.; Zagreev, B. V.; Matafonov, A. P.
2015-07-01
Various theoretical and experimental schemes for implementing a thermonuclear reactor on the basis of the p+11B reaction are considered. They include beam collisions, fusion in degenerate plasmas, ignition upon plasma acceleration by ponderomotive forces, and the irradiation of a solid-state target from 11B with a proton beam under conditions of a Coulomb explosion of hydrogen microdrops. The possibility of employing ultra-short high-intensity laser pulses to initiate the p+11B reaction under conditions far from thermodynamic equilibrium is discussed. This and some other weakly radioactive thermonuclear reactions are promising owing to their ecological cleanness—there are virtually no neutrons among fusion products. Nuclear reactions that follow the p+11B reaction may generate high-energy protons, sustaining a chain reaction, and this is an advantage of the p+11B option. The approach used also makes it possible to study nuclear reactions under conditions close to those in the early Universe or in the interior of stars.
International Nuclear Information System (INIS)
Robatel, M.; Bochard, C.
1986-01-01
The ROBATEL RS 24 packaging for light-water reactor fuel assemblies is discussed. The cask uses a strength frame of carbon steel sheets, lead gamma ray shielding, neutron shielding of aluminous concrete, a thermal protection system for the gamma shielding, and a natural convection thermal transfer system
Stochastic models of edge turbulent transport in the thermonuclear reactors
International Nuclear Information System (INIS)
Volchenkov, Dima
2005-01-01
Two-dimensional stochastic model of turbulent transport in the scrape-off layer (SOL) of thermonuclear reactors is considered. Convective instability arisen in the system with respect to perturbations reveals itself in the strong outward bursts of particle density propagating ballistically across the SOL. The criterion of stability for the fluctuations of particle density is formulated. A possibility to stabilize the system depends upon the certain type of plasma waves interactions and the certain scenario of turbulence. A bias of limiter surface would provide a fairly good insulation of chamber walls excepting for the resonant cases. Pdf of the particle flux for the large magnitudes of flux events is modeled with a simple discrete time toy model of I-dimensional random walks concluding at the boundary. The spectra of wandering times feature the pdf of particle flux in the model and qualitatively reproduce the experimental statistics of transport events
Joint development effort Thermonuclear Fusion. Programme budgeting 1984
International Nuclear Information System (INIS)
1985-01-01
The joint KfK and IPP project for the development of thermonuclear fusion device is established as the centerpiece of Federal German efforts in this field. It is meant to enhance the German contribution to the European programme and thus foster the chances of a joint European large-scale experiment to be started in the Federal Republic of Germany. IPP's tasks in the project are to study the physical principles and aspects, whereas KfK is responsible for the technological aspects. Work at IPP is focused on divertor experiments with the ASDEX series in order to go deeper into the problems that could not be solved by the JET experiments, namely those of the plasma boundary and control of impurities. Stellarator experiments are made in order to study the potentials of this toroidal confinement concept for steady-state operation. The IPP which always has been working in the plasma physics field devotes all activities to the joint effort. KfK has established a special project group for this purpose, PKF. The budgeting programme presented therefore covers the IPP entire working schedule, and that of PKF of the KfK. (orig./GG) [de
Vad ersätter företagets avbrottsförsäkring?
Rosenqvist, Felix
2010-01-01
I arbetet redogörs för hur en avbrottsförsäkring är uppbyggd och hur ersättningen räknas ut i praktiken. I teoridelen behandlas försäkringshistoria, de frivilliga skadeförsäkringarna och mera djupgående avbrottsförsäkringen. Skadehanteringsprocessen beskrivs också i teoridelen. För att åskådliggöra ämnet har själva resultatredovisnigen förverkligats genom en fiktiv fallstudie. Detta för att göra det enklare för läsaren att förstå hur avbrottsförsäkringen fungerar i praktiken...
Association of the ENPP1 rs997509 polymorphism with obesity in ...
African Journals Online (AJOL)
) polymorphisms have been associated with metabolic traits. There is no data on the effect of ENPP1 in South African children or adults. Objective: To investigate the role of K121Q (rs1044498), rs997509 and rs9402349 in obesity and other ...
Use of liquid metals in nuclear and thermonuclear engineering, and in other innovative technologies
Rachkov, V. I.; Arnol'dov, M. N.; Efanov, A. D.; Kalyakin, S. G.; Kozlov, F. A.; Loginov, N. I.; Orlov, Yu. I.; Sorokin, A. P.
2014-05-01
By now, a good deal of experience has been gained with using liquid metals as coolants in nuclear power installations; extensive knowledge has been gained about the physical, thermophysical, and physicochemical properties of these coolants; and the scientific principles and a set of methods and means for handling liquid metals as coolants for nuclear power installations have been elaborated. Prototype and commercialgrade sodium-cooled NPP power units have been developed, including the BOR-60, BN-350, and BN-600 power units (the Soviet Union); the Rapsodie, Phenix, and Superphenix power units (France), the EBR-II power unit (the United States); and the PFR power unit (the United Kingdom). In Russia, dedicated nuclear power installations have been constructed, including those with a lead-bismuth coolant for nuclear submarines and with sodium-potassium alloy for spacecraft (the Buk and Topol installations), which have no analogs around the world. Liquid metals (primarily lithium and its alloy with lead) hold promise for use in thermonuclear power engineering, where they can serve not only as a coolant, but also as tritium-producing medium. In this article, the physicochemical properties of liquid metal coolants, as well as practical experience gained from using them in nuclear and thermonuclear power engineering and in innovative technologies are considered, and the lines of further research works are formulated. New results obtained from investigations carried out on the Pb-Bi and Pb for the SVBR and BREST fast-neutron reactors (referred to henceforth as fast reactors) and for controlled accelerator systems are described.
Cryogenic instrumentation needs in the controlled thermonuclear research program
International Nuclear Information System (INIS)
Walstrom, P.L.
1976-01-01
The magnet development effort for the controlled thermonuclear research program will require extensive testing of superconducting coils at various sizes from small-scale models to full-size prototypes. Extensive use of diagnostic instrumentation will be required and to make detailed comparisons of predicted and actual performance in magnet tests and to monitor the test facility for incipient failure modes. At later stages of the program, cryogenic instrumentation will be required to monitor magnet system performance in fusion power reactors. Measured quantities may include temperature, strain, deflection, coil resistance, helium coolant pressure and flow, current, voltages, etc. The test environment, which includes high magnetic fields (up to 8-10 T) and low temperature, makes many commercial measuring devices inoperative or at least inaccurate. In order to ensure reliable measurements, careful screening of commercial devices for performance in the test environment will be required. A survey of potentially applicable instrumentation is presented along with available information on operation in the test environment based on experimental data or on analysis of the physical characteristics of the device. Areas where further development work is needed are delineated
Thermonuclear dynamo inside ultracentrifuge with supersonic plasma flow stabilization
Energy Technology Data Exchange (ETDEWEB)
Winterberg, F. [University of Nevada, Reno, Reno, Nevada (United States)
2016-01-15
Einstein's general theory of relativity implies the existence of virtual negative masses in the rotational reference frame of an ultracentrifuge with the negative mass density of the same order of magnitude as the positive mass density of a neutron star. In an ultracentrifuge, the repulsive gravitational field of this negative mass can simulate the attractive positive mass of a mini-neutron star, and for this reason can radially confine a dense thermonuclear plasma placed inside the centrifuge, very much as the positive mass of a star confines its plasma by its own attractive gravitational field. If the centrifuge is placed in an externally magnetic field to act as the seed field of a magnetohydrodynamic generator, the configuration resembles a magnetar driven by the release of energy through nuclear fusion, accelerating the plasma to supersonic velocities, with the magnetic field produced by the thermomagnetic Nernst effect insulating the hot plasma from the cold wall of the centrifuge. Because of the supersonic flow and the high plasma density the configuration is stable.
Thermonuclear dynamo inside ultracentrifuge with supersonic plasma flow stabilization
Winterberg, F.
2016-01-01
Einstein's general theory of relativity implies the existence of virtual negative masses in the rotational reference frame of an ultracentrifuge with the negative mass density of the same order of magnitude as the positive mass density of a neutron star. In an ultracentrifuge, the repulsive gravitational field of this negative mass can simulate the attractive positive mass of a mini-neutron star, and for this reason can radially confine a dense thermonuclear plasma placed inside the centrifuge, very much as the positive mass of a star confines its plasma by its own attractive gravitational field. If the centrifuge is placed in an externally magnetic field to act as the seed field of a magnetohydrodynamic generator, the configuration resembles a magnetar driven by the release of energy through nuclear fusion, accelerating the plasma to supersonic velocities, with the magnetic field produced by the thermomagnetic Nernst effect insulating the hot plasma from the cold wall of the centrifuge. Because of the supersonic flow and the high plasma density the configuration is stable.
Thermonuclear dynamo inside ultracentrifuge with supersonic plasma flow stabilization
International Nuclear Information System (INIS)
Winterberg, F.
2016-01-01
Einstein's general theory of relativity implies the existence of virtual negative masses in the rotational reference frame of an ultracentrifuge with the negative mass density of the same order of magnitude as the positive mass density of a neutron star. In an ultracentrifuge, the repulsive gravitational field of this negative mass can simulate the attractive positive mass of a mini-neutron star, and for this reason can radially confine a dense thermonuclear plasma placed inside the centrifuge, very much as the positive mass of a star confines its plasma by its own attractive gravitational field. If the centrifuge is placed in an externally magnetic field to act as the seed field of a magnetohydrodynamic generator, the configuration resembles a magnetar driven by the release of energy through nuclear fusion, accelerating the plasma to supersonic velocities, with the magnetic field produced by the thermomagnetic Nernst effect insulating the hot plasma from the cold wall of the centrifuge. Because of the supersonic flow and the high plasma density the configuration is stable
Thermonuclear model for x-ray transients
International Nuclear Information System (INIS)
Wallace, R.K.; Woosley, S.E.; Weaver, T.A.
1982-01-01
The thermonuclear evolution of a 1.41 M sub solar neutron star accreting both solar and metal-deficient mixtures of hydrogen, helium, and heavy elements at rates ranging from about 10 -11 to 10 -10 M sub solar per year is examined using a one-dimensional numerical model. The metal deficient compositions may result either from placement of the neutron star in a binary system with a Population II red giant or from gravitational settling of heavy ions in the accreted material. For such accretion rates and metallicities, hydrogen burning, mediated by the β-limited CNO cycle, is stable and leads to the accumulation of a thick helium layer with mass 10 23 to 10 25 g and temperature 0.7 less than or equal to T 8 less than or equal to 1.2. Helium ignition occurs under extremely degenerate circumstances and is catastrophically violent. In the lower t helium shells this runaway is propagated as a convective deflagration, for the thicker layers a detonation front is set up which steepens into a strong relativistic shock wave in the neutron star envelope. In all models greatly super-Eddington luminosities in the outer layers of the neutron star lead to a sustained epoch of radiatively driven mass loss. Observationally, such models may correspond to rapid x-ray transients. The hopeless prospect for constructing a one-dimensional model for γ-ray bursts without magnetic field confinement is discussed and uncertainties pointed out in the strong screening correction for helium burning reaction
RS-34 (Peacekeeper Post Boost Propulsion System) Orbital Debris Application Concept Study
Esther, Elizabeth A.; Burnside, Christopher G.
2013-01-01
The Advanced Concepts Office (ACO) at the NASA Marshall Space Flight Center (MSFC) lead a study to evaluate the Rocketdyne produced RS-34 propulsion system as it applies to an orbital debris removal design reference mission. The existing RS-34 propulsion system is a remaining asset from the de-commissioned United States Air Force Peacekeeper ICBM program; specifically the pressure-fed storable bi-propellant Stage IV Post Boost Propulsion System. MSFC gained experience with the RS-34 propulsion system on the successful Ares I-X flight test program flown in the Ares I-X Roll control system (RoCS). The heritage hardware proved extremely robust and reliable and sparked interest for further utilization on other potential in-space applications. Subsequently, MSFC is working closely with the USAF to obtain all the remaining RS-34 stages for re-use opportunities. Prior to pursuit of securing the hardware, MSFC commissioned the Advanced Concepts Office to understand the capability and potential applications for the RS-34 Phoenix stage as it benefits NASA, DoD, and commercial industry. Originally designed, the RS-34 Phoenix provided in-space six-degrees-of freedom operational maneuvering to deploy multiple payloads at various orbital locations. The RS-34 Concept Study, preceded by a utilization study to understand how the unique capabilities of the RS-34 Phoenix and its application to six candidate missions, sought to further understand application for an orbital debris design reference mission as the orbital debris removal mission was found to closely mimic the heritage RS-34 mission. The RS-34 Orbital Debris Application Concept Study sought to identify multiple configurations varying the degree of modification to trade for dry mass optimization and propellant load for overall capability and evaluation of several candidate missions. The results of the RS-34 Phoenix Utilization Study show that the system is technically sufficient to successfully support all of the missions
International Nuclear Information System (INIS)
1990-01-01
This is a report concerning the participation of the Instituto de Pesquisas Espaciais in the national program for plasma physics and controlled thermonuclear fusion. The report lists all the personnel enroled in research activities, both theoretical and experimental. The research subjects are the following: relativistic electron beams; plasma produced by laser; plasma theory; quiescent plasma; plasma centrifugal; ionic propulsion. (A.C.A.S.) [pt
Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide
International Nuclear Information System (INIS)
Hoobakht, Fatemeh; Ganji, Fariba; Vasheghani-Farahani, Ebrahim; Mousavi, Seyyed Mohammad
2013-01-01
Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 °C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1–4 and 20 % of loaded PB released from the nanocarriers within 100 h
Eudragit RS PO nanoparticles for sustained release of pyridostigmine bromide
Energy Technology Data Exchange (ETDEWEB)
Hoobakht, Fatemeh; Ganji, Fariba, E-mail: fganji@modares.ac.ir; Vasheghani-Farahani, Ebrahim [Tarbiat Modares University, Biomedical Engineering Group, Chemical Engineering Department (Iran, Islamic Republic of); Mousavi, Seyyed Mohammad [Tarbiat Modares University, Biotechnology Group, Chemical Engineering Department (Iran, Islamic Republic of)
2013-09-15
Pyridostigmine bromide (PB) is an inhibitor of cholinesterase, which is used in the treatment of myasthenia gravis and administered for protection against exposure to toxic nerve agents. Tests were done to investigate prolonging the half-life of PB and improving its release behavior. PB was loaded in nanoparticles (NPs) of Eudragit RS PO (Eu-RS) prepared using the technique of quasi emulsion solvent diffusion. Variables of output power of the sonicator, bath temperature and mixing time, were chosen as the optimization factors to obtain the minimum sized NPs. In addition, emulsions were tested at different ratios of drug-to-polymer by dynamic light scattering to determine size and zeta potential of NPs. UV-spectroscopy was used to determine PB content of the NPs. Drug-loaded NPs were characterized by scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectra. Results determined that mixing time had a significant impact on the size of Eu-RS NPs, but power output of sonicator and bath temperature had no significant effect. The particle size obtained at the optimum condition (power output of 70 W, bath temperature of 33 Degree-Sign C, and mixing time of 7 min) was less than 200 nm (optimum sizes were 138.9 and 179.5 nm for Eu-RS and PB-loaded Eu-RS NPs, respectively). The optimum PB-loaded Eu-RS NPs at the PB to Eu-RS weight ratio of 1-4 and 20 % of loaded PB released from the nanocarriers within 100 h.
Li, Yaping; Zhai, Song; Li, Mei; Wang, Yuan; Lu, Tong; Deng, Huiling; Zhang, Xin; Dang, Shuangsuo
2017-07-01
Objective To investigate whether the polymorphisms of TLR7/MyD88 signaling pathway is associated with the susceptibility to and severity of hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) in children. Methods We collected 180 EV71 HFMD cases and 201 healthy controls from both the Second Affiliated Hospital of Xi'an Jiaotong University and Xi'an Children's Hospital. The genotypes including rs3853839, rs179010 of TLR7, and rs7744 of MyD88 were detected in the 381 samples by SNPscan kit. Results The susceptibility risk (OR=2.343, 95%CI:1.516-3.621) and severity risk (OR=1.939, 95%CI: 1.064-3.521) of TLR7 rs3853839 allele C significantly increased in the male children with EV71 HFMD. Also, the susceptibility risk (OR=1.701, 95%CI: 1.142-2.535) and severity risk (OR=1.852, 95%CI: 1.038-3.305) of TLR7 rs179010 allele T significantly increased in the male children with EV71 HFMD. But there was no significant difference in the distribution of TLR7 rs179010 and rs3853839 genes between female children with EV71 HFMD and female controls. There was no correlation between the genetic polymorphisms of MyD88 rs7744 and the susceptibility to and severity of EV71 HFMD in the children. Conclusion Polymorphisms of TLR7 rs3853839 and rs179010 are correlated to the susceptibility to and severity of EV71 HFMD in male children.
Infrared observations of RS CVn stars
International Nuclear Information System (INIS)
Berriman, G.; De Campli, W.M.; Werner, M.W.; Hatchett, S.P.
1983-01-01
Infrared photometry is presented of the RS CVn binary stars AR Lac (1.2-10 μm) and MM Her (1.2-3.5 μm) as they egressed from their primary and secondary eclipses; of the eclipsing systems RS CVn and Z Her at maximum light (1.2-10 μm) and of the non-eclipsing systems UX Ari and HR 1099 (1.2-10 μm). An analysis of these and published V data based on flux ratio diagrams (linear analogues of colour-colour diagrams) shows that G and K stars supply the infrared light of these systems. None of these systems shows infrared emission from circumstellar matter. (author)
RS-Predictor models augmented with SMARTCyp reactivities
DEFF Research Database (Denmark)
Zaretzki, Jed; Rydberg, Patrik; Bergeron, Charles
2012-01-01
(82.3%) and merged(86.0%). Comprehensive datamining of each substrate set and careful statistical analyses of the predictions made by the different models revealed new insights into molecular features that control metabolic regioselectivity and enable accurate prospective prediction of likely SOMs.......RS-Predictor is a tool for creating pathway-independent, isozyme-specific site of metabolism (SOM) prediction models using any set of known cytochrome P450 substrates and metabolites. Until now, the RS-Predictor method was only trained and validated on CYP 3A4 data, but in the present study we...... report on the versatility the RS-Predictor modeling paradigm by creating and testing regioselectivity models for substrates of the nine most important CYP isozymes. Through curation of source literature, we have assembled 680 substrates distributed among CYPs 1A2, 2A6, 2B6, 2C19, 2C8, 2C9, 2D6, 2E1 and 3...
Industrial opportunities on the International Thermonuclear Experimental Reactor (ITER) project
International Nuclear Information System (INIS)
Ellis, W.R.
1996-01-01
Industry has been a long-term contributor to the magnetic fusion program, playing a variety of important roles over the years. Manufacturing firms, engineering-construction companies, and the electric utility industry should all be regarded as legitimate stakeholders in the fusion energy program. In a program focused primarily on energy production, industry's future roles should follow in a natural way, leading to the commercialization of the technology. In a program focused primarily on science and technology, industry's roles, in the near term, should be, in addition to operating existing research facilities, largely devoted to providing industrial support to the International Thermonuclear Experimental Reactor (ITER) Project. Industrial opportunities on the ITER Project will be guided by the amount of funding available to magnetic fusion generally, since ITER is funded as a component of that program. The ITER Project can conveniently be discussed in terms of its phases, namely, the present Engineering Design Activities (EDA) phase, and the future (as yet not approved) construction phase. 2 refs., 3 tabs
Reflectometry and transport in thermonuclear plasmas in the Joint European Torus
International Nuclear Information System (INIS)
Sips, A.C.C.
1991-01-01
The subjects of this thesis are the study of microwave reflectometry as a method to measure electron density profiles, and the study of particle and energy transport in thermonuclear plasmas. In the transport studies data of a 12-channel reflectometer system are used to analyze the propagation of electron density perturbations in the plasma. The measurements described in this thesis are performed in the plasmas in the Joint European Torus (JET). The main points of study described are based on microwave reflectometry, the principles of which are given. Two modes of operation of a reflectometer are described. Firstly, electro-magnetic waves with constant frequencies may be launched into the plasma to measure variations in the electron density profile. Secondly, the absolute density profile can be measured with a reflectometer, when the source frequencies are swept. (author). 56 refs.; 41 figs.; 5 tabs
8 GHz, high power, microwave system for heating of thermonuclear plasmas
International Nuclear Information System (INIS)
Di Giovenale, S.; Fortunato, T.; Mirizzi, F.; Roccon, M.; Sassi, M.; Tuccillo, A.A.; Maffia, G.; Baldi, L.
1993-01-01
The Frascati Tokamak Upgrade (FTU) is a machine included in the European Thermonuclear Fusion Program aimed at investigating high density plasmas in the presence of powerful additional RF heating systems. The Lower Hybrid Resonant Heating (LHRH) system, based on 9 independent modules, works at 8 GHz, and will generate, at full performances, a total amount of 9 MW, in the pulsed regime (pulse length = 1 s, duty cycle = 1/600). The microwave power source is a gyrotron oscillator, developed by Thomson Tubes Electroniques (France) for this specific application, and capable of producing up to 1 MW. An overmoded, low loss, circular waveguide transmits the RF power toward the plasma; an array of 12x4 rectangular waveguides (the 'grill') launches this power into the plasma. The paper describes the LHRH system for FTU and analyses both its main performances and experimental results
International Nuclear Information System (INIS)
Wesley, J.C.
1997-01-01
Present status and understanding of the principal plasma-performance determining physics issues that affect the physics design and operational capabilities of the International Thermonuclear Experimental Reactor (ITER) [ITER EDA Agreement and Protocol 2 (International Atomic Energy Agency, Vienna, 1994)] are presented. Emphasis is placed on the five major physics-basis issues emdash energy confinement, beta limit, density limit, impurity dilution and radiation loss, and the feasibility of obtaining partial-detached divertor operation emdash that directly affect projections of ITER fusion power and burn duration performance. A summary of these projections is presented and the effect of uncertainties in the physics-basis issues is examined. ITER capabilities for experimental flexibility and plasma-performance optimization are also described, and how these capabilities may enter into the ITER physics program plan is discussed. copyright 1997 American Institute of Physics
Directory of Open Access Journals (Sweden)
King-Wah Chiu
Full Text Available To investigate the effect of IL28B single nucleotide polymorphisms (SNPs (rs8099917 and rs12979860 in the donors and recipients on the outcome of Hepatitis C virus-RNA clearance after living donor liver transplantation (LDLT. The rs8099917 and rs12979860 genotypes in 50 donor and recipients pairs were explored on the pre-operative day (POD and post-operative day 30 (POD30. There was a significant difference in HCV-RNA clearance before (12%, 6/50 and after (48%, 24/50 liver transplantation (P < 0.001. The rs8099917 genotype TT was dominant in both the recipients (82%, 41/50 and donors (86%, 43/50, but had no significant effect on HCV-RNA clearance (87.5%, 21/24 and recurrence (76.9%, 20/26 after LDLT. One recipient was detected with genotype GG on POD, which changed to genotype GT on POD30. Prevalence of rs12979860 genotype CT was 98% (49/50 recipient and 92% (46/50 donor and prevalence of genotype CC was 2% (1/50 recipient and 8% (4/50 donor on POD and POD30, respectively. Of the 4 recipients with rs12979860 genotype CC on POD30, 3 recipients (12.5%, 3/24 exhibited HCV clearance and 1 experienced recurrence (3.9%, 1/26, however, this was not statistically significant. In conclusion, alterations in IL28B SNP genotype may occur after LDLT, leading to modifications in the host genome or donor proteome by HCV. This predicted mechanism will need to be investigated further.
RS-485 Bus Design of a Missile Simulation Training System
Directory of Open Access Journals (Sweden)
Liu Fang
2013-07-01
Full Text Available In a missile simulation training system with one-master and multi-slaves distributed system structure, a universal controller is necessary due to the system composed with several controllers. In this research, the designed controllers communicate with each other and upper control computer through RS-485 field bus. RS-485 bus including interface circuits, transmission protocol, Cyclic Redundancy Check (CRC method and upper control test software is designed and proposed. The universal controller adopting the designed RS-485 interface circuits is connected through twisted-pair and makes the simulation system, then the controller is tested in line. The results show that the RS-485 bus communicates effectively using the protocol and CRC method, data transmission rates reaches 115.2 kbps, and has a good stability.
The Drosha rs10719 T>C polymorphism is associated with preeclampsia susceptibility.
Rezaei, Mahnaz; Eskandari, Fatemeh; Mohammadpour-Gharehbagh, Abbas; Teimoori, Batool; Yaghmaei, Minoo; Mokhtari, Mojgan; Salimi, Saeedeh
2018-01-01
Drosha is a member of the micro RNA (miRNA) processing machinery that affects miRNA processing. Single-nucleotide polymorphisms (SNPs) in the Drosha gene might affect microRNA processing and the expression of various genes. The aim of this study is to investigate the association between SNPs in the Drosha gene and preeclampsia (PE) in the southeast of Iran. Genotyping of Drosha rs10719 and rs6877842 was performed using blood samples from 219 PE women and 205 healthy control subjects by a polymerase chain reaction-restriction fragment length polymorphism method. The Drosha rs10719TC genotype was significantly associated with 1.6-fold higher risk of PE (odds ratio (OR, 1.6 [95% CI, 1.1-2.4], P = 0.026). In addition, the frequency of the Drosha rs10719CC genotype was significantly higher in PE women and was associated with threefold higher risk of PE (OR 3 [95% CI 1.4-6.3], P = 0.004). There was no association between the Drosha rs6877842 polymorphism and PE susceptibility. The CC-GG combined genotype was associated with 3.4-fold higher risk of PE (OR 3.4 [95% CI 1.4-8.1], P = 0.007). The haplotype-based association analysis showed higher frequency of C-G haplotype of Drosha rs10719 and rs6877842 polymorphisms with the increased risk of PE 1.5-fold (OR 1.5 [95% CI 1.1 - 2], P = 0.01). The Drosha rs10719TC and CC genotypes were associated with PE risk. The CC-GG combined genotype and C-G haplotype of Drosha rs10719 and rs6877842 polymorphisms may increase PE susceptibility.
Association between MC4R rs17782313 polymorphism and overeating behaviors.
Yilmaz, Z; Davis, C; Loxton, N J; Kaplan, A S; Levitan, R D; Carter, J C; Kennedy, J L
2015-01-01
Melanocortins have a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behavior and depressed mood. We genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviors was obtained during the in-person assessment. BMI was associated with rs17782313 C allele; however, this finding did not survive correction for multiple testing (P = 0.018). Although rs17782313 was significantly associated with depressed mood and overeating behaviors, tests of indirect effects indicated that emotional eating and food cravings, rather than depressed mood, uniquely accounted for the effect of this marker and BMI (n = 152). To our knowledge, this is the first study to investigate the link between MC4R rs17782313, mood and overeating behavior, as well as to demonstrate possible mechanisms behind MC4R's influence on body weight. If replicated in a larger sample, these results may have important clinical implications, including potential for the use of MC4R agonists in the treatment of obesity and disordered eating.
Younus, Laith A; Algenabi, Abdul Hussein A; Abdul-Zhara, Mohammed S; Hussein, Majid K
2017-09-05
The variation of the SNPs in FTO (fat mass and obesity associated) gene are improved to be associated with obesity and type 2 diabetes (T2DM) in some ethnic groups for example in European while, this consistency is controversial in Asians and there were few studies in Iraqi population about the effect of this gene on the development of T2DM in obese patients. Therefore, the objective of this study is to investigate the impact of the two common FTO gene variants in the development of T2DM in obese Iraqi patients. A case-control study in which the FTO gene variants rs9939609 and rs17817449 were genotyping in a total of 800 individuals, 400 T2DM obese patients (patients group) and 400 healthy control obese volunteers (control group) to explore the relation of these SNPs with T2DM in obese Iraqi population. The patients group was enrolled from diabetic clinic in Al Najaf al Ashraf based on WHO guidelines of T2DM. From whole blood the DNA was extraction and genotyped by using ScaI and AlwNI enzymes respectively in the PCR-RFLP technique. Multinomial logistic regression was applied to compare the proportions of genotypes and alleles. The odd's ratio, t-test P value at 95% confidence interval were measured before and after adjustment of BMI, age and sex adjustment. The genetic power, Hardy Weinberg equilibrium and haplotype analysis were tested in the present study. It was observed that the presence of T allele in the two SNPs rs9939609 and rs17817449 in the FTO gene polymorphisms was associated with increased risk for the development of T2DM in Iraqi obese individuals. The minor allele (T) in rs9939609 was significantly higher (P=0.0001) in T2DM (31.25%) when compared with that of the control obese group (20%). The Homozygous genotype (TT) significantly (OR=3.25, CI 95% 1.87-5.64, P=0.000) increased the risk of T2DM by three folds with respect to those of wild type (AA) after adjustment for age, sex and BMI, furthermore, it was significantly increased the risk in the
International Nuclear Information System (INIS)
Langlais, Gilles
1999-01-01
The work presented in this report has been performed in the frame of fusion safety studies for thermonuclear reactors of ITER type (International Thermonuclear Experimental Reactor). It is particularly related to the thermal and two-phases thermalhydraulic studies of heat exchangers facing plasma. These components are submitted to unidirectional high heat flux between 1 to 10 MW/m 2 . The cooling fluid is then heat by an anisotropic heat flux. This non-uniform distribution induces the presence of different heat transfer on the cooling channel (single phase forced convection, subcooled nucleate boiling). The thermal and the thermalhydraulic three-dimensional study has been performed using experimental data and coupled computer calculations developed in the frame of this thesis work. The heat transfer between solid and fluid are modelled using correlations selected after the bibliography study. These heat exchange correlations as well as the CHF ones have been assessed by comparison to the available experimental data. This allowed to modify the single phase heat transfer correlation and to select two CHF correlations. (author) [fr
Takahashi, Hakuo; Yoshika, Masamichi; Yokoi, Toyohiko
2013-01-01
Allowing patients to measure their blood pressure at home is recognized as being of clinical value. However, it is not known how often these measurements are taken correctly. Blood pressure monitors for home use fall into two types based on the position of the cuff, ie, at the upper arm or the wrist. The latter is particularly convenient, as measurements can be taken fully clothed. This study aimed to evaluate the performance of the wrist-type blood pressure monitors Omron RS8 (HEM-6310F-E), Omron RS6 (HEM-6221-E), and Omron RS3 (HEM-6130-E). A team of three trained doctors validated the performance of these devices by comparing the measurements obtained from these devices with those taken using a standard mercury sphygmomanometer. All the devices met the validation requirements of the European Society of Hypertension International Protocol revision 2010. The difference in blood pressure readings between the tested device and the standard mercury sphygmomanometer was within 3 mmHg, which is acceptable according to the European Society of Hypertension guidelines. All the home devices tested were found to be suitable for measuring blood pressure at home because their performance fulfilled the requirement of the guidelines.
Association between MC4R rs17782313 Polymorphism and Overeating Behaviours
Yilmaz, Zeynep; Davis, Caroline; Loxton, Natalie J.; Kaplan, Allan S.; Levitan, Robert D.; Carter, Jacqueline C.; Kennedy, James L.
2014-01-01
Background/Objectives Melanocortins play a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behaviour, and depressed mood. Subjects/Methods We genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviours was obtained during the in-person assessment. Results BMI was associated with rs17782313 C allele; however this finding did not survive correction for multiple testing (p=0.018). Although rs17782313 was significantly associated with depressed mood and overeating behaviours, tests of indirect effects indicated that emotional eating and food cravings, rather than depressed mood, uniquely accounted for the effect of this marker and BMI (n=152). Conclusions To our knowledge, this is the first study to investigate the link between MC4R rs17782313, mood and overeating behaviour, as well as to demonstrate possible mechanisms behind MC4R’s influence on body weight. If replicated in a larger sample, these results may have important clinical implications, including potential for the use of MC4R agonists in the treatment of obesity and disordered eating. PMID:24827639
International Nuclear Information System (INIS)
Budrick, R.G.; Nolen, R.L. Jr.; Solomon, D.E.; King, F.T.
1975-01-01
The invention relates to the manufacture of glass microspheres. It refers to a method according to which a sintered glass-powder, whose particles are calibrated, is introduced into a blow-pipe adapted to project said glass-powder particles into a heated flue, said sintered glass-powder containing a pore-forming agent adapted to expand the glass particles into microspheres which are collected in a chamber situated abode said flue. The method can be applied to the manufacture of microspheres adapted to contain a thermonuclear fuel [fr
Directory of Open Access Journals (Sweden)
S Madani
2014-02-01
Results: Regarding rs1049305, the C minor allele showed more frequency in patients' group (0.47 vs. 0.37. The results revealed that GG genotype presents less probable risk for menorrhagia. rs10244884 also shows the same frequency. Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.
The ARIES-RS power core - recent development in Li/V designs
International Nuclear Information System (INIS)
Sze Dai-Kai; Billone, M.C.; Hua, T.Q.; Tillack, M.; Najmabadi, F.; Wang Xueren; Malang, S.; El-Guebaly, L.A.; Sviatoslavsky, I.N.; Blanchard, J.P.; Crowell, J.A.; Khater, H.Y.; Mogahed, E.A.; Waganer, L.M.; Lee, D.; Cole, D.
1998-01-01
The ARIES-RS fusion power plant design study is based on reversed-shear (RS) physics with a Li/V (lithium breeder and vanadium structure) blanket. The reversed-shear discharge has been documented in many large tokamak experiments. The plasma in the RS mode has a high beta, low current, and low current drive requirement. Therefore, it is an attractive physics regime for a fusion power plant. The blanket system based on Li/V has high temperature operating capability, good tritium breeding, excellent high heat flux removal capability, long structural life time, low activation, low after heat and good safety characteristics. For these reasons, the ARIES-RS reactor study selected Li/V as the reference blanket. The combination of attractive physics and attractive blanket engineering is expected to result in a superior power plant design. This paper summarizes the power core design of the ARIES-RS power plant study. (orig.)
Directory of Open Access Journals (Sweden)
Alicja E. Grzegorzewska
2018-05-01
Full Text Available Background/Aims: The calcium-sensing receptor gene (CASR rs1801725 variant is responsible for a non-conservative amino-acid change (A986S in the calcium-sensing receptor cytoplasmic tail. We hypothesized that rs1801725 polymorphism might be helpful in understanding Ca-related abnormalities in HD patients. Methods: In 1215 subjects (245 on cinacalcet, we determined the associations of rs1801725 with secondary hyperparathyroidism (sHPT-related laboratory parameters, PTH-decreasing effect of cinacalcet hydrochloride, coronary artery disease (CAD, myocardial infarction (MI, nephrolithiasis-related ESRD, and mortality. CASR rs7652589(A
International Nuclear Information System (INIS)
Reid, R.L.; Galambos, J.D.; Peng, Y.K.M.
1988-09-01
Energy confinement scaling is a major concern in the design of the International Thermonuclear Experimental Reactor (ITER). The existing database for tokamaks can be fitted with a number of different confinement scaling expressions that have similar degrees of approximation. These scaling laws predict confinement times for ITER that vary by over an order of magnitude. The uncertainties in the form and magnitude of these scaling laws must be substantially reduced before the plasma performance of ITER can be predicted with adequate reliability. The TETRA systems code is used to calculate the dependence of major ITER parameters on the scaling laws currently in use. Design constraints of interest in the present phase of ITER consideration are used, and the minimum-cost devices arising from these constraints are reviewed. 9 refs., 13 figs., 4 tabs
Genetic association of polymorphism rs1333049 with gout.
Wang, Binbin; Meng, Dongmei; Wang, Jing; Liu, Shiguo; Zhou, Sirui; Miao, Zhimin; Han, Lin; Chu, Nan; Zhang, Kun; Ma, Xu; Li, Changgui
2011-09-01
We suspect that genes or loci that contribute to coronary artery disease (CAD) may also play a role in the pathogenesis of gout, since hyperuricaemia leads to gout, and serum uric acid (SUA) levels are potential risk factors for CAD. The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD. The aim of this study was to evaluate the relationship between this SNP and gout pathogenesis. Nine hundred Chinese Han were recruited for this study (461 gout patients and 439 gout-free individuals). The rs1333049 SNP and surrounding sequences were PCR sequenced. There was a clear link between the rs1333049 genotypic and allelic frequencies between gout cases and controls (χ(2) = 6.81, df = 2, P = 0.033 by genotype; χ(2) = 6.63, df = 1, P = 0.01 by allele). There was a significantly increased risk of gout in carriers of the CC genotype (odds ratio = 1.43, 95% CI 1.07, 1.91). To the best of our knowledge, our findings are the first to establish an association of rs1333049 with gout in a Chinese Han population. Meanwhile, this SNP is homologous to miR-519 and miR-520.
International research co-operation in the field of controlled thermonuclear fusion
International Nuclear Information System (INIS)
Conscience, J.-F.
2003-01-01
This final report for the Swiss Federal Office of Education and Science presents a review of activities carried out in 2002 within the framework of the International Experimental Thermonuclear Reactor (ITER) project that involves contributions from Canada, Japan, the Russian Federation and the European Union. Further agreements on the development of a fusion reactor with other countries, including Switzerland, the USA and China, are mentioned. The first chapter describes the current state of research on electricity production using nuclear fusion and discusses feasibility, safety, environmental, fuel supply and economic aspects. A second chapter reviews global efforts in the fusion area, including ITER and EURATOM projects and the activities running under the European Fusion Development Agreement EFDA and the JET Implementing Agreement. Finally, a third chapter deals with fusion research activities in Switzerland and the contributions made to international research by Swiss universities and institutes
El-Lebedy, Dalia; Raslan, Hala; Ibrahim, Alshaymaa; Ashmawy, Ingy; El-Aziz, Shereen Abd; Mohammed, Asmaa M
2017-09-01
The aim of this study was to investigate association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) rs2476601 and signal transducer and activator of transcription 4 (STAT4) rs7574865 polymorphisms with rheumatoid arthritis (RA) susceptibility and to assess potential association with the status of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibodies, serum neopterin, and disease activity. RF, anti-CCP antibodies, and neopterin were assayed in serum of 100 unrelated RA patients and 114 controls. STAT4 rs7574865 G/T and PTPN22 rs2476601 C/T polymorphisms were genotyped by the TaqMan allelic discrimination method. The frequency of STAT4 variant allele was significantly higher in RA patients than in controls (p = 0.01), while the variant allele of PTPN22 was identified in only two RA patients, in a heterozygous form and in none of control subjects. The frequency of STAT4 variant allele carrier genotypes (GT+TT) was significantly higher among RA patients than in controls (43.7 vs. 10.5%, p = 0.02) and associated with RA under additive and dominant models. The frequency of RF and anti-CCP positivity was significantly higher among RA patients carrying T allele genotypes compared to patients carrying wild genotype (P = 0.02 and 0.04, respectively). No significant associations between STAT4 variant and serum neopterin or disease activity parameters were identified. Our study confirmed the association of STAT4 rs7574865 polymorphism with RA and was the first to indicate an association with RF and anti-CCP antibodies positivity. We also found PTPN22 rs2476601 has no role in susceptibility to RA in Egyptian patients.
Mahrooz, Abdolkarim; Alizadeh, Ahad; Hashemi-Soteh, Mohammad Bagher; Ghaffari-Cherati, Maryam; Hosseyni-Talei, Seyyedeh Raheleh
2017-02-01
In this study, we investigated whether two common variants (rs3088442G>A and rs2292334G>A) in the organic cation transporter 3 (OCT3) gene, a high-capacity transporter widely expressed in various tissues, affect susceptibility to type 2 diabetes (T2D) in patients newly diagnosed with T2D. We performed a study with 150 newly diagnosed patients with T2D and 152 controls. The genetic analyses were performed using the restricted fragment length polymorphism (RFLP) after PCR amplification. For the rs3088442G>A variant, A allele carriers had a significantly lower odds ratio (OR) vs. GG homozygotes in the BMI A variant was associated with a decreased risk of T2D (OR = 0.016, p A in the 3'-untranslated region of the OCT3 gene in susceptibility to T2D, and that the protective role is maintained in the presence of risky alleles of the variant rs2292334G>A. The association of the A allele of rs3088442G>A with T2D become weaker in obese people than that of non-obese. If confirmed in other populations, the rs3088442G>A variant as a genetic marker may potentially assist in the identification of individuals at an increased risk of T2D. Copyright © 2017 IMSS. Published by Elsevier Inc. All rights reserved.
Henchen, Robert; Esham, Benjamin; Becker, William; Pogozelski, Edward; Padalino, Stephen; Sangster, Thomas; Glebov, Vladimir
2008-11-01
The High-Speed Rapid Pneumatic Transport of Radioactive Samples (HS-RaPToRS) system, designed to quickly and safely move radioactive materials, was assembled and tested at the Mercury facility of the Naval Research Laboratory (NRL) in Washington D.C. A sample, which is placed inside a four-inch-diameter carrier, is activated before being transported through a PVC tube via airflow. The carrier travels from the reaction chamber to the end station where it pneumatically brakes prior to the gate. A magnetic latch releases the gate when the carrier arrives and comes to rest. The airflow, optical carrier-monitoring devices, and end gate are controlled manually or automatically with LabView software. The installation and testing of the RaPToRS system at NRL was successfully completed with transport times of less than 3 seconds. The speed of the carrier averaged 16 m/s. Prospective facilities for similar systems include the Laboratory for Laser Energetics and the National Ignition Facility.
International Nuclear Information System (INIS)
Peña-Chilet, Maria; Ribas, Gloria; Blanquer-Maceiras, Maite; Ibarrola-Villava, Maider; Martinez-Cadenas, Conrado; Martin-Gonzalez, Manuel; Gomez-Fernandez, Cristina; Mayor, Matias; Aviles, Juan Antonio; Lluch, Ana
2013-01-01
Few high penetrance genes are known in Malignant Melanoma (MM), however, the involvement of low-penetrance genes such as MC1R, OCA2, ASIP, SLC45A2 and TYR has been observed. Lately, genome-wide association studies (GWAS) have been the ideal strategy to identify new common, low-penetrance susceptibility loci. In this case–control study, we try to validate in our population nine melanoma associated markers selected from published GWAS in melanoma predisposition. We genotyped the 9 markers corresponding to 8 genes (PARP1, MX2, ATM, CCND1, NADSYN1, CASP8, IRF4 and CYP2R1) in 566 cases and 347 controls from a Spanish population using KASPar probes. Genotypes were analyzed by logistic regression and adjusted by phenotypic characteristics. We confirm the protective role in MM of the rs3219090 located on the PARP1 gene (p-value 0.027). Additionally, this SNP was also associated with eye color (p-value 0.002). A second polymorphism, rs12203592, located on the IRF4 gene was associated with protection to develop MM for the dominant model (p-value 0.037). We have also observed an association of this SNP with both lentigines (p-value 0.014) and light eye color (p-value 3.76 × 10 -4 ). Furthermore, we detected a novel association with rs1485993, located on the CCND1 gene, and dark eye color (p-value 4.96 × 10 -4 ). Finally, rs1801516, located on the ATM gene, showed a trend towards a protective role in MM similar to the one firstly described in a GWAS study. To our knowledge, this is the first time that these SNPs have been associated with MM in a Spanish population. We confirmed the proposed role of rs3219090, located on the PARP1 gene, and rs12203592, located on the IRF4 gene, as protective to MM along the same lines as have previous genome-wide associated works. Finally, we have seen associations between IRF4, PARP1, and CCND1 and phenotypic characteristics, confirming previous results for the IRF4 gene and presenting novel data for the last two, suggesting that
International Nuclear Information System (INIS)
Wang, Songtao; Yan, Qing; Chen, Pin; Zhao, Peng; Gu, Aihua
2014-01-01
Research has indicated that the rs12203592 and rs872071 interferon regulatory factor 4 (IRF4) gene polymorphisms correlate with the risk of cancer, especially skin cancer and haematological malignancies, but the results remain controversial. To understand better the effects of these two polymorphisms on skin cancer and haematological malignancies susceptibility, a cumulative meta-analysis was performed. We conducted a search using the PubMed and Web of Science databases for relevant case-control studies published before April 2014. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using fixed- or random-effects models where appropriate. Heterogeneity test, publication bias test, and sensitivity analysis were also performed. In total, 11 articles comprised of 19 case–control studies were identified; five focused on the rs12203592 polymorphism with 7,992 cases and 8,849 controls, and six were on the rs872071 polymorphism with 3108 cases and 8300 controls. As for rs12203592, a significant correlation with overall skin cancer and haematological malignancies risk was found with the homozygote comparison model (OR = 1.566, 95% CI 1.087-2.256) and recessive model (OR = 1.526, 95% CI 1.107-2.104). For rs872071, a significantly elevated haematological malignancies risk was observed in all genetic models (homozygote comparison: OR = 1.805, 95% CI 1.402-2.323; heterozygote comparison: OR = 1.427, 95% CI 1.203-1.692; dominant: OR = 1.556, 95% CI 1.281-1.891; recessive: OR = 1.432, 95% CI 1.293-1.587; additive: OR = 1.349, 95% CI 1.201-1.515). Similarly, increased skin cancer and haematological malignancies risk was also identified after stratification of the SNP data by cancer type, ethnicity and source of controls for both polymorphisms. Our meta-analysis indicated that the rs12203592 and rs872071 IRF4 gene polymorphisms are associated with individual susceptibility to skin cancer and haematological malignancies. Moreover, the effect
Dreiseitel, Jiří
2012-01-01
Práce je věnována problematice konstrukce převodníku Ethernet na RS-232 za pomocí jednočipového mikrokontroléru. Cílem je seznámit čtenáře se síťovou technologií Ethernet a technologií pro sériový přenos založený na protokolu RS-232 a zároveň s technologií vestavěných systémů pro konstrukci zařízení. Součástí práce je kompletní návrh převodníku Ethernet na RS-232 včetně návrhu a implementace firmware v jazyce C za využití LwIP TCP/IP stacku. Převodník je postaven na základě vývojového kitu ST...
G. Fubiani; H. P. L. de Esch; A. Simonin; R. S. Hemsworth
2008-01-01
The negative ion electrostatic accelerator for the neutral beam injector of the International Thermonuclear Experimental Reactor (ITER) is designed to deliver a negative deuterium current of 40 A at 1 MeV. Inside the accelerator there are several types of interactions that may create secondary particles. The dominating process originates from the single and double stripping of the accelerated negative ion by collision with the residual molecular deuterium gas (≃29% losses). The resulting seco...
Study on parallel and distributed management of RS data based on spatial database
Chen, Yingbiao; Qian, Qinglan; Wu, Hongqiao; Liu, Shijin
2009-10-01
With the rapid development of current earth-observing technology, RS image data storage, management and information publication become a bottle-neck for its appliance and popularization. There are two prominent problems in RS image data storage and management system. First, background server hardly handle the heavy process of great capacity of RS data which stored at different nodes in a distributing environment. A tough burden has put on the background server. Second, there is no unique, standard and rational organization of Multi-sensor RS data for its storage and management. And lots of information is lost or not included at storage. Faced at the above two problems, the paper has put forward a framework for RS image data parallel and distributed management and storage system. This system aims at RS data information system based on parallel background server and a distributed data management system. Aiming at the above two goals, this paper has studied the following key techniques and elicited some revelatory conclusions. The paper has put forward a solid index of "Pyramid, Block, Layer, Epoch" according to the properties of RS image data. With the solid index mechanism, a rational organization for different resolution, different area, different band and different period of Multi-sensor RS image data is completed. In data storage, RS data is not divided into binary large objects to be stored at current relational database system, while it is reconstructed through the above solid index mechanism. A logical image database for the RS image data file is constructed. In system architecture, this paper has set up a framework based on a parallel server of several common computers. Under the framework, the background process is divided into two parts, the common WEB process and parallel process.
Murphy, T. J.; Douglas, M. R.; Cardenas, T.; Cooley, J. H.; Gunderson, M. A.; Haines, B. M.; Hamilton, C. E.; Kim, Y.; Lee, M. N.; Oertel, J. A.; Olson, R. E.; Randolph, R. B.; Shah, R. C.; Smidt, J. M.
2017-10-01
The MARBLE campaign on NIF investigates the effect of heterogeneous mix on thermonuclear burn for comparison to a probability distribution function (PDF) burn model. MARBLE utilizes plastic capsules filled with deuterated plastic foam and tritium gas. The ratio of DT to DD neutron yield is indicative of the degree to which the foam and the gas atomically mix. Platform development experiments have been performed to understand the behavior of the foam and of the gas separately using two types of capsule. The first experiments using deuterated foam and tritium gas have been performed. Results of these experiments, and the implications for our understanding of thermonuclear burn in heterogeneously mixed separated reactant experiments will be discussed. This work is supported by US DOE/NNSA, performed at LANL, operated by LANS LLC under contract DE-AC52-06NA25396.
Czech Academy of Sciences Publication Activity Database
Bilski, P.; Blomgren, J.; d´Errico, F.; Esposito, A.; Fehrenbacher, G.; Fernández, F.; Fuchs, A.; Golnik, N.; Lacoste, V.; Leuschner, A.; Sandri, S.; Silari, M.; Spurný, František; Wiegel, B.; Wright, P.
2007-01-01
Roč. 126, 1-4 (2007), s. 491-496 ISSN 0144-8420 R&D Projects: GA MŠk 1P05OC032 Grant - others:ES(XE) Contract no FI6R-012684 Institutional research plan: CEZ:AV0Z10480505 Keywords : radiation fields * european high-energy accelerators * thermonuclear fusion facilities Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders Impact factor: 0.528, year: 2007
Controlled thermonuclear fusion: research on magnetic fusion
International Nuclear Information System (INIS)
Paris, P.J.
1988-12-01
Recent progress in thermonuclear fusion research indicates that the scientists' schedule for the demonstration of the scientific feasibility will be kept and that break-even will be attained in the course of the next decade. To see the implementation of ignition, however, the generation of future experiments must be awaited. These projects are currently under study. With technological research going on in parallel, they should at the same time contribute to the design of a reactor. Fusion reactors will be quite different from the fission nuclear reactors we know, and the waste of the plants will also be of a different nature. It is still too early to define the precise design of a fusion reactor. On the basis of a toric machine concept like that of the tokamak, we can, however, envisage that the problems with which we are confronted will be solved one after the other. As we have just seen, these will be the objectives of the future experimental installations where ignition will be possible and where the flux of fast neutrons will be so strong that they will allow the study of low-activation materials which will be used in the structure of the reactor. But this is also a task in which from now onwards numerous laboratories in Europe and in the world participate. The works are in fact punctiform, and often the mutual incidences can only be determined by an approach simulated by numerical codes. (author) 19 figs., 6 tabs., 8 refs
Polymorphism of glucagon-like peptide-1 receptor gene (rs1042044 ...
African Journals Online (AJOL)
patience
2015-02-16
Feb 16, 2015 ... turnover via GLP-1 receptors (GLP1Rs) in postmenopausal state. Furthermore, polymorphisms in. GLP1R gene were suggested to affect the function of GLP1Rs and be associated with many diseases. However, the relationships between GLP1R polymorphisms and osteoporosis susceptibility and bone.
Polymorphism of glucagon-like peptide-1 receptor gene (rs1042044 ...
African Journals Online (AJOL)
Previous investigations indicated that glucagon-like peptide-1 (GLP-1) played important roles in bone turnover via GLP-1 receptors (GLP1Rs) in postmenopausal state. Furthermore, polymorphisms in GLP1R gene were suggested to affect the function of GLP1Rs and be associated with many diseases. However, the ...
Configuration control plan for the ports NCS IBM RS/6000
International Nuclear Information System (INIS)
Brown, A.S.
1996-01-01
This document describes the actions and responsibilities for maintaining the quality and integrity of the NS software resident on the IBM RS/6000 workstation managed by the Nuclear Criticality Safety group at the Portsmouth Gaseous Diffusion Plant. This document does not address the validation of NS software packages for the RS/6000
BDNF rs6265 methylation and genotype interact on risk for schizophrenia.
Ursini, Gianluca; Cavalleri, Tommaso; Fazio, Leonardo; Angrisano, Tiziana; Iacovelli, Luisa; Porcelli, Annamaria; Maddalena, Giancarlo; Punzi, Giovanna; Mancini, Marina; Gelao, Barbara; Romano, Raffaella; Masellis, Rita; Calabrese, Francesca; Rampino, Antonio; Taurisano, Paolo; Di Giorgio, Annabella; Keller, Simona; Tarantini, Letizia; Sinibaldi, Lorenzo; Quarto, Tiziana; Popolizio, Teresa; Caforio, Grazia; Blasi, Giuseppe; Riva, Marco A; De Blasi, Antonio; Chiariotti, Lorenzo; Bollati, Valentina; Bertolino, Alessandro
2016-01-01
Epigenetic mechanisms can mediate gene-environment interactions relevant for complex disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to environmental stressors, such as hypoxia, and harbors the functional SNP rs6265 (Val(66)Met), which creates or abolishes a CpG dinucleotide for DNA methylation. We found that methylation at the BDNF rs6265 Val allele in peripheral blood of healthy subjects is associated with hypoxia-related early life events (hOCs) and intermediate phenotypes for schizophrenia in a distinctive manner, depending on rs6265 genotype: in ValVal individuals increased methylation is associated with exposure to hOCs and impaired working memory (WM) accuracy, while the opposite is true for ValMet subjects. Also, rs6265 methylation and hOCs interact in modulating WM-related prefrontal activity, another intermediate phenotype for schizophrenia, with an analogous opposite direction in the 2 genotypes. Consistently, rs6265 methylation has a different association with schizophrenia risk in ValVals and ValMets. The relationships of methylation with BDNF levels and of genotype with BHLHB2 binding likely contribute to these opposite effects of methylation. We conclude that BDNF rs6265 methylation interacts with genotype to bridge early environmental exposures to adult phenotypes, relevant for schizophrenia. The study of epigenetic changes in regions containing genetic variation relevant for human diseases may have beneficial implications for the understanding of how genes are actually translated into phenotypes.
International Nuclear Information System (INIS)
Meade, D.M.
1975-01-01
Impurity ions adversely affect the behavior of present-day tokamaks, and control of impurities is expected to be a key element in determining the feasibility of thermonuclear fusion reactors. The plasma-surface interactions for tokamaks and several techniques for controlling impurities are described. The plasma-surface problem of next generation devices PLT, PDX, DIII and TFTR is expected to be similar to those encountered in a reactor. For these devices calculations indicate that most of the particle energy efflux will be in the 1 keV region. Ironically this energy region has not yet been investigated thoroughly by the surface physicists
Igniting the Light Elements: The Los Alamos Thermonuclear Weapon Project, 1942-1952
Energy Technology Data Exchange (ETDEWEB)
Fitzpatrick, Anne C. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States)
1999-07-01
The American system of nuclear weapons research and development was conceived and developed not as a result of technological determinism, but by a number of individual architects who promoted the growth of this large technologically-based complex. While some of the technological artifacts of this system, such as the fission weapons used in World War II, have been the subject of many historical studies, their technical successors--fusion (or hydrogen) devices--are representative of the largely unstudied highly secret realms of nuclear weapons science and engineering. In the postwar period a small number of Los Alamos Scientific Laboratory's staff and affiliates were responsible for theoretical work on fusion weapons, yet the program was subject to both the provisions and constraints of the US Atomic Energy Commission, of which Los Alamos was a part. The Commission leadership's struggle to establish a mission for its network of laboratories, least of all to keep them operating, affected Los Alamos's leaders' decisions as to the course of weapons design and development projects. Adapting Thomas P. Hughes's ''large technological systems'' thesis, I focus on the technical, social, political, and human problems that nuclear weapons scientists faced while pursuing the thermonuclear project, demonstrating why the early American thermonuclear bomb project was an immensely complicated scientific and technological undertaking. I concentrate mainly on Los Alamos Scientific Laboratory's Theoretical, or T, Division, and its members' attempts to complete an accurate mathematical treatment of the ''Super''--the most difficult problem in physics in the postwar period--and other fusion weapon theories. Although tackling a theoretical problem, theoreticians had to address technical and engineering issues as well. I demonstrate the relative value and importance of H-bomb research over time in the postwar era to
Schnitzler, Fabian; Friedrich, Matthias; Wolf, Christiane; Angelberger, Marianne; Diegelmann, Julia; Olszak, Torsten; Beigel, Florian; Tillack, Cornelia; Stallhofer, Johannes; Göke, Burkhard; Glas, Jürgen; Lohse, Peter; Brand, Stephan
2014-01-01
Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP) rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD) (Cell 2013;155:57-69). The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery. We genotyped 550 CD patients for rs12212067 (FOXO3A) and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses. No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847) was highly associated with penetrating CD (p = 0.01), the development of fistulas (p = 0.01) and stenoses (p = 0.01), and ileal disease localization (p = 0.03). Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5)), while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35). 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p = 0.007). In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847), in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A rs12212067 SNP for a mild disease course on an individual patient level despite its
Directory of Open Access Journals (Sweden)
Rifet Terzić
2017-11-01
Full Text Available Diabetic retinopathy (DR is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA. A previous study demonstrated that two single nucleotide polymorphisms (SNPs, rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM. This case-control study enrolled 1037 unrelated Slovenian individuals (Caucasians with T2DM. DR group included 415 T2DM patients with DR, while control group included 622 T2DM patients with no clinical signs of DR. The clinical and laboratory data were obtained from the medical records of the patients. The genotyping of rs6921438 and rs10738760 SNPs was carried out with real-time PCR assays. Significant differences were observed between patients with DR and controls in the duration of diabetes (p < 0.001, insulin therapy (p < 0.001, glycated hemoglobin (p = 0.001, body mass index (p = 0.002, total cholesterol (p = 0.002, and low-density lipoprotein cholesterol (p < 0.001. However, we did not observe significant differences in the genotype and allele distribution of the two SNPs, between DR and control group (p < 0.05. Logistic regression analysis showed that rs6921438 and rs10738760 were not independent genetic risk factors for DR in the co-dominant model adjusted for the above-mentioned clinical and laboratory data. In conclusion, VEGF-related SNPs rs10738760 and rs6921438 are not associated with DR in our group of Slovenian patients (Caucasians with T2DM.
Zhang, Jingfa; Qin, Qiming
2003-09-01
Many types of feature extracting of RS image are analyzed, and the work procedure of pattern recognizing in RS images of seismic disaster is proposed. The aerial RS image of Tangshan Great Earthquake is processed, and the digital features of various typical seismic disaster on the RS image is calculated.
Energy Technology Data Exchange (ETDEWEB)
in' t Zand, J. J.M. [SRON Netherlands Institute for Space Research, Utrecht (The Netherlands); Malone, Christopher M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Altamirano, D. [Univ. of Southampton, Southampton (United Kingdom); Ballantyne, D. R. [Georgia Inst. of Technology, Atlanta, GA (United States); Bhattacharyya, S. [Tata Institute of Fundamental Research, Mumbai (India); Brown, E. F. [Michigan State Univ., East Lansing, MI (United States); Cavecchi, Y. [Univ. of Amsterdam, Amsterdam (The Netherlands); Chakrabarty, D. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Chenevez, J. [Technical Univ. of Denmark, Lyngby (Denmark); Cumming, A. [McGill Univ., Montreal, QC (Canada); Degenaar, N. [Univ. of Cambridge, Cambridge (United Kingdom); Falanga, M. [International Space Science Institute, Bern (Switzerland); Galloway, D. K. [Monash Univ., VIC (Australia); Heger, A. [Monash Univ., VIC (Australia); Jose, J. [Univ. Politecnica de Catalunya, Barcelona (Spain); Institut d' Estudis Espacials de Catalunya, Barcelona (Spain); Keek, L. [Georgia Institute of Technology, Atlanta, GA (United States); Linares, M. [Univ. de La Laguna, Tenerife (Spain); Mahmoodifar, S. [Univ. of Maryland, College Park, MD (United States); Mendez, M. [Univ. of Groningen, Groningen (The Netherlands); Miller, M. C. [Univ. of Maryland, College Park, MD (United States); Paerels, F. B. S. [Columbia Astrophysics Lab., New York, NY (United States); Poutanen, J. [Univ. of Turku, Piikkio (Finland); Rozanska, A. [N. Copernicus Astronomical Center PAS, Warsaw (Poland); Schatz, H. [National Superconducting Cyclotron Laboratory at Michigan State University; Serino, M. [Institute of Physical and Chemical Research (RIKEN); Strohmayer, T. E. [NASA' s Goddard Space Flight Center, Greenbelt, MD (United States); Suleimanov, V. F. [Univ. Tubingen, Tubingen (Germany); Thielemann, F. -K. [Univ. Basel, Basel (Switzerland); Watts, A. L. [Univ. of Amsterdam, Amsterdam (The Netherlands); Weinberg, N. N. [Massachusetts Institute of Technology, Cambridge, MA (United States); Woosley, S. E. [Univ. of California, Santa Cruz, CA (United States); Yu, W. [Chinese Academy of Sciences (CAS), Shanghai (China); Zhang, S. [Institute of High-Energy Physics, Beijing (China); Zingale, M. [Stony Brook Univ., Stony Brook, NY (United States)
2015-01-14
The Large Area Detector (LAD) on the Large Observatory For X-ray Timing ( LOFT ), with a 8.5 m 2 photon- collecting area in the 2–30 keV bandpass at CCD-class spectral resolving power (λ/Δλ = 10 – 100), is designed for optimum performance on bright X-ray sources. Thus, it is well-suited to study thermonuclear X-ray bursts from Galactic neutron stars. These bursts will typically yield 2 x 105 photon detections per second in the LAD, which is at least 15 times more than with any other instrument past, current or anticipated. The Wide Field Monitor (WFM) foreseen for LOFT uniquely combines 2–50 keV imaging with large (30%) prompt sky coverage. This will enable the detection of tens of thousands of thermonuclear X-ray bursts during a 3-yr mission, including tens of superbursts. Both numbers are similar or more than the current database gathered in 50 years of X-ray astronomy.
Lakbakbi El Yaagoubi, F; Charoute, H; Bakhchane, A; Ajjemami, M; Benrahma, H; Errouagui, A; Kandil, M; Rouba, H; Barakat, A
2015-12-01
The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n=164) and non-obese (n=295). All subjects were genotyped for the APOA5 -1131T>C (rs662799) and c.56C>G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T>C and c.56C>G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI]=3.09 [1.93-4.97]; P<0.001). These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
Evaluation of IFITM3 rs12252 Association With Severe Pediatric Influenza Infection.
Randolph, Adrienne G; Yip, Wai-Ki; Allen, Emma Kaitlynn; Rosenberger, Carrie M; Agan, Anna A; Ash, Stephanie A; Zhang, Yu; Bhangale, Tushar R; Finkelstein, David; Cvijanovich, Natalie Z; Mourani, Peter M; Hall, Mark W; Su, Helen C; Thomas, Paul G
2017-07-01
Interferon-induced transmembrane protein 3 (IFITM3) restricts endocytic fusion of influenza virus. IFITM3 rs12252_C, a putative alternate splice site, has been associated with influenza severity in adults. IFITM3 has not been evaluated in pediatric influenza. The Pediatric Influenza (PICFLU) study enrolled children with suspected influenza infection across 38 pediatric intensive care units during November 2008 to April 2016. IFITM3 was sequenced in patients and parents were genotyped for specific variants for family-based association testing. rs12252 was genotyped in 54 African-American pediatric outpatients with influenza (FLU09), included in the population-based comparisons with 1000 genomes. Splice site analysis of rs12252_C was performed using PICFLU and FLU09 patient RNA. In PICFLU, 358 children had influenza infection. We identified 22 rs12252_C homozygotes in 185 white non-Hispanic children. rs12252_C was not associated with influenza infection in population or family-based analyses. We did not identify the Δ21 IFITM3 isoform in RNAseq data. The rs12252 genotype was not associated with IFITM3 expression levels, nor with critical illness severity. No novel rare IFITM3 functional variants were identified. rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity. Our data also do not support it being a splice site. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
Directory of Open Access Journals (Sweden)
Sun-Hyung Lim
2017-11-01
Full Text Available The MYB-bHLH-WDR (MBW complex activates anthocyanin biosynthesis through the transcriptional regulation. RsMYB1 has been identified as a key player in anthocyanin biosynthesis in red radish (Raphanus sativus L., but its partner bHLH transcription factor (TF remains to be determined. In this study, we isolated a bHLH TF gene from red radish. Phylogenetic analysis indicated that this gene belongs to the TT8 clade of the IIIF subgroup of bHLH TFs, and we thus designated this gene RsTT8. Subcellular localization analysis showed that RsTT8-sGFP was localized to the nuclei of Arabidopsis thaliana protoplasts harboring the RsTT8-sGFP construct. We evaluated anthocyanin biosynthesis and RsTT8 expression levels in three radish varieties (N, C, and D that display different red phenotypes in the leaves, root flesh, and root skins. The root flesh of the C variety and the leaves and skins of the D variety exhibit intense red pigmentation; in these tissues, RsTT8 expression showed totally positive association with the expression of RsMYB1 TF and of five of eight tested anthocyanin biosynthesis genes (i.e., RsCHS, RsCHI, RsF3H, RsDFR, and RsANS. Heterologous co-expression of both RsTT8 and RsMYB1 in tobacco leaves dramatically increased the expression of endogenous anthocyanin biosynthesis genes and anthocyanin accumulation. Furthermore, a yeast two-hybrid assay showed that RsTT8 interacts with RsMYB1 at the MYB-interacting region (MIR, and a transient transactivation assay indicated that RsTT8 activates the RsCHS and RsDFR promoters when co-expressed with RsMYB1. Complementation of the Arabidopsis tt8-1 mutant, which lacks red pigmentation in the leaves and seeds, with RsTT8 restored red pigmentation, and resulted in high anthocyanin and proanthocyanidin contents in the leaves and seeds, respectively. Together, these results show that RsTT8 functions as a regulatory partner with RsMYB1 during anthocyanin biosynthesis.
Association between rs6812193 polymorphism and sporadic Parkinson's disease susceptibility.
Huo, Qiang; Li, Tao; Zhao, Peiqing; Wang, Lianqing
2015-08-01
Recently, the association of a single nucleotide polymorphism rs6812193 C/T with sporadic Parkinson's disease (PD) susceptibility has been widely evaluated, but the results remained inconsistent. This association should be clarified because of the importance of it on human health and quality of life. We performed a comprehensive meta-analysis to evaluate the association between the rs6812193 polymorphism and sporadic PD. PubMed was used to retrieve articles published up to June 2014 for all studies evaluating the rs6812193 polymorphism and PD in humans. Ethnicity-specific subgroup analysis was also performed based on ethnicity susceptibility. A total of 17 independent study samples (15 Caucasians and 2 Asians) including 17,956 cases and 52,751 controls were used in the presented study. The MAFT (minor allele T frequency) in PD patients of European descent is obviously higher than Asian cases (p susceptibility among overall samples (OR 0.882, 95 % CI 0.856-0.908) and Caucasian population (OR 0.881, 95 % CI 0.856-0.907), but not in Asian samples (OR 0.918, 95 % CI 0.721-1.168). No evidence of publication bias was observed. Throughout our analysis, the rs6812193 polymorphism is significantly associated with sporadic PD susceptibility in Caucasian samples, and ethnicity might be the key point of inconsistency in rs6812193 studies. Further studies are warranted to re-examine the observed associations, especially in different ethnicities.
rs3806268 of NLRP3 gene polymorphism is associated with the development of primary gout.
Deng, Jianping; Lin, Wen; Chen, Yunpeng; Wang, Xin; Yin, Zhong; Yao, Chunhong; Liu, Tangbing; Lv, Yonghong
2015-01-01
The aim of the present study was to investigate the association between seven functional SNPs in NALP3 gene and the susceptibility to primary gout. A total of 247 patients with primary gout and 247 controls were selected in this study. Genotyping of NALP3 rs4612666, rs3806268, rs12239046, rs10754558, rs7512998, rs12137901 and rs12565738 was performed using the Sequenom MassARRAY platform. Comparison analysis showed that primary gout patients were more likely to have a higher body mass index, DBP, SBP, TG, urea nitrogen and uric acid (P gout when compared with the AA genotype (OR=1.83, 95% CI=1.03-3.26). However, no significant associations were identified for the remaining SNPs. In conclusion, we found a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population. Further clinical and genetic studies are required to investigate the mechanisms underlying the association between NALP3 polymorphisms and the development of primary gout.
2002-01-01
Dr Robert Aymar, Director of the International Thermonuclear Experimental Reactor (ITER), was nominated to succeed Professor Luciano Maiani as CERN's Director General, to take office on 1 January 2004.
Polymorphisms in TRPV1 and TAS2Rs associate with sensations from sampled ethanol.
Allen, Alissa L; McGeary, John E; Hayes, John E
2014-10-01
Genetic variation in chemosensory genes can explain variability in individual's perception of and preference for many foods and beverages. To gain insight into variable preference and intake of alcoholic beverages, we explored individual variability in the responses to sampled ethanol (EtOH). In humans, EtOH elicits sweet, bitter, and burning sensations. Here, we explore the relationship between variation in EtOH sensations and polymorphisms in genes encoding bitter taste receptors (TAS2Rs) and a polymodal nociceptor (TRPV1). Caucasian participants (n = 93) were genotyped for 16 single nucleotide polymorphisms (SNPs) in TRPV1, 3 SNPs in TAS2R38, and 1 SNP in TAS2R13. Participants rated sampled EtOH on a generalized Labeled Magnitude Scale. Two stimuli were presented: a 16% EtOH whole-mouth sip-and-spit solution with a single time-point rating of overall intensity and a cotton swab saturated with 50% EtOH on the circumvallate papillae (CV) with ratings of multiple qualities over 3 minutes. Area-under-the-curve (AUC) was calculated for the time-intensity data. The EtOH whole-mouth solution had overall intensity ratings near "very strong." Burning/stinging had the highest mean AUC values, followed by bitterness and sweetness. Whole-mouth intensity ratings were significantly associated with burning/stinging and bitterness AUC values on the CV. Three TRPV1 SNPs (rs224547, rs4780521, rs161364) were associated with EtOH sensations on the CV, with 2 (rs224547 and rs4780521) exhibiting strong linkage disequilibrium. Additionally, the TAS2R38 SNPs rs713598, rs1726866, and rs10246939 formed a haplotype, and were associated with bitterness on the CV. Last, overall intensity for whole-mouth EtOH associated with the TAS2R13 SNP rs1015443. These data suggest genetic variation in TRPV1 and TAS2Rs influence sensations from sampled EtOH and may potentially influence how individuals initially respond to alcoholic beverages. Copyright © 2014 by the Research Society on Alcoholism.
Impact of Gene rs7422339 Polymorphism in Argentine Patients With Hyperhomocysteinemia
Directory of Open Access Journals (Sweden)
Silene M. Silvera-Ruiz BSc
2015-05-01
Full Text Available Carbamoyl phosphate synthetase 1 ( CPS1 is a key gene in the first step of urea cycle and has been correlated with nitric oxide level and vascular smooth muscle activity. A functional single-nucleotide polymorphism C/A at position 4217 in CPS1 (National Center for Biotechnology Information SNP database no. rs7422339, T1405N was reported to be associated with high homocysteine (Hcy plasma values. Although genetic variants of methylenetetrahydrofolate reductase ( MTHFR gene are known to influence Hcy concentration, other genetic determinants of Hcy remain largely unknown. The association between the CPS1 rs7422339 and the risk of hyperhomocysteinemia in Latin American populations is unknown. Here, we study this association in 100 patients having hyperhomocysteinemia without MTHFR c.677C>T polymorphism and 100 controls. CPS1 rs7422339 was studied using polymerase chain reaction and enzymatic restriction. Comparisons of the CPS1 rs7422339 genotype distributions revealed a significant difference between groups ( P = 2.3 × 10 −3 . Patients carrying polymorphic allele showed almost 3 times higher risk (odds ratio [OR] = 2.47 of hyperhomocysteinemia than wild-type allele, suggesting that rs7422339 SNP is associated with high Hcy levels in the Argentine population.
Directory of Open Access Journals (Sweden)
Fabian Schnitzler
Full Text Available Very recently, a sub-analysis of genome-wide association scans revealed that the non-coding single nucleotide polymorphism (SNP rs12212067 in the FOXO3A gene is associated with a milder course of Crohn's disease (CD (Cell 2013;155:57-69. The aim of our study was to evaluate the clinical value of the SNP rs12212067 in predicting the severity of CD by correlating CD patient genotype status with the most relevant complications of CD such as stenoses, fistulas, and CD-related surgery.We genotyped 550 CD patients for rs12212067 (FOXO3A and the three common CD-associated NOD2 mutations rs2066844, rs2066847, and rs2066847 and performed genotype-phenotype analyses.No significant phenotypic differences were found between the wild-type genotype TT of the FOXO3A SNP rs12212067 and the minor genotypes TG and GG independently from NOD2 variants. The allele frequency of the minor G allele was 12.7%. Age at diagnosis, disease duration, body mass index, surgery rate, stenoses, fistula, need for immunosuppressive therapy, and disease course were not significantly different. In contrast, the NOD2 mutant p.Leu1007fsX1008 (rs2066847 was highly associated with penetrating CD (p = 0.01, the development of fistulas (p = 0.01 and stenoses (p = 0.01, and ileal disease localization (p = 0.03. Importantly, the NOD2 SNP rs2066847 was a strong separator between an aggressive and a mild course of CD (p = 2.99×10(-5, while the FOXO3A SNP rs12212067 did not separate between mild and aggressive CD behavior in our cohort (p = 0.35. 96.2% of the homozygous NOD2 p.Leu1007fsX1008 carriers had an aggressive disease behavior compared to 69.3% of the patients with the NOD2 wild-type genotype (p = 0.007.In clinical practice, the NOD2 variant p.Leu1007fsX1008 (rs2066847, in particular in homozygous form, is a much stronger marker for a severe clinical phenotype than the FOXO3A rs12212067 SNP for a mild disease course on an individual patient level despite
Directory of Open Access Journals (Sweden)
Jun Yin
Full Text Available Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associated death worldwide. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancer carcinogenesis. We conducted a hospital based case-control study to evaluate the genetic susceptibility of functional single nucleotide polymorphisms (SNPs in the microRNAs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC cases and 686 controls were recruited for this study. The hsa-miR-34b/c rs4938723 T>C, pri-miR-124-1 rs531564 C>G, pre-miR-125a rs12975333 G>T and hsa-miR-423 rs6505162 C>A genotypes were determined using Ligation Detection Reaction (LDR method. Our results demonstrated that hsa-miR-34b/c rs4938723 CC genotype had a decreased risk of ESCC. The association was evident among patients who never drinking. Hsa-miR-423 rs6505162 C>A might associated with a significantly increased risk of ESCC in patients who smoking. These findings indicated that functional polymorphisms hsa-miR-34b/c rs4938723 T>C and hsa-miR-423 rs6505162 C>A might alter individual susceptibility to ESCC. However, our results were obtained with a limited sample size. Future larger studies with other ethnic populations are required to confirm current findings.
The common variant rs11646213 is associated with preeclampsia in Han Chinese women.
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Ji-peng Wan
Full Text Available BACKGROUND: Preeclampsia, characterized by hypertension and proteinuria, is a multifactorial disease caused by complex interactions between environmental and genetic factors. A recent genome-wide association study of blood pressure reported an association between hypertension and rs11646213. This study evaluated the association between preeclampsia and rs11646213. METHODS: A total of 454 cases and 460 controls were recruited to participate in this study. The single nucleotide polymorphism (SNP rs11646213 was genotyped by polymerase chain reaction (PCR and direct sequencing. RESULTS: The allele frequency of rs11646213 was significantly different between the preeclampsia and control groups (P = 0.017, OR = 1.36, 95% CI = 1.06-1.76. Differences were particularly significant in the severe preeclampsia subgroup (P = 0.002, OR = 1.54, 95% CI = 1.17-2.03 and the early-onset preeclampsia subgroup (P = 0.004, OR = 1.57, 95% CI = 1.16-2.13. Genotyping analysis showed that the T allele of rs11646213 could confer a risk for preeclampsia, severe preeclampsia and early-onset preeclampsia. CONCLUSIONS: Rs11646213 upstream of the CDH13 gene is associated with preeclampsia in Han Chinese women.
Resiliency Scale (RS): Scale Development, Reliability and Validity Study
GÜRGAN, Uğur
2003-01-01
The purpose of this study was to develop a new Resiliency Scale (RS) for Turkish samples. Various items from some major resiliency scales, most of them with some partial change, were collected and a pool of 228 items containing almost all possible resilience areas were obtained. This item-pool was administered to a college sample of 419. Resulting of analysis 50 item RS were obtained and administered to a new college sample of 112 participants. This second sample has also received the Rosenba...
The 3Rs principle – mind the ethical gap!
DEFF Research Database (Denmark)
Olsson, I. Anna S.; Franco, Nuno H.; Weary, Daniel M.
2012-01-01
to believe that full implementation is merely a matter of time, and once the 3Rs are widely implemented, the public will fully support any continued laboratory animal use that is deemed necessary. In this paper, we argue that these conclusions are unlikely to be correct, in part because the 3Rs are rich...... effects of repeated exposure to harmful procedures). We conclude that there is now a need for a more thorough ethical discussion on how to resolve these issues....
International Nuclear Information System (INIS)
Kalsi, S.S.; Lousteau, D.C.; Miller, J.R.
1987-01-01
The International Thermonuclear Experimental Reactor (ITER) is a new tokamak design project with joint participation from Europe, Japan, the Union of Soviet Socialist Republics (USSR), and the United States. This paper describes a magnetic and mechanical design methodology for toroidal field (TF) coils that employs Nb/sub 3/Sn superconductor technology. Coil winding is sized by using conductor concepts developed for the US TIBER concept. The nuclear heating generated during operation is removed from the windings by helium flowing through the conductor. The heat in the coil case is removed through a separate cooling circuit operating at approximately 20 K. Manifold concepts are presented for the complete coil cooling system. Also included are concepts for the coil structural arrangement. The effects of in-plane and out-of-plane loads are included in the design considerations for the windings and case. Concepts are presented for reacting these loads with a minimum amount of additional structural material. Concepts discussed in this paper could be considered for the ITER TF coils. 6 refs., 5 figs., 1 tab
International Nuclear Information System (INIS)
Petti, D.A.; Haire, J.C.
1993-12-01
The International Thermonuclear Experimental Reactor (ITER) is the first fusion machine that will have sufficient decay heat and activation product inventory to pose potential nuclear safety concerns. As a result, nuclear safety and environmental issues will be much more important in the approval process for the design, siting, construction, and operation of ITER in the United States than previous fusion devices, such as the Tokamak Fusion Test Reactor. The purpose of this report is (a) to provide an overview of the regulatory approval process for a Department of Energy (DOE) nuclear facility; (b) to present the dose limits used by DOE to protect workers, the public, and the environment from the risks of exposure to radiation and hazardous materials; (c) to discuss some key nuclear safety-related issues that must be addressed early in the Engineering Design Activities (EDA) to obtain regulatory approval; and (d) to provide general guidelines to the ITER Joint Central Team (JCT) concerning the development of a regulatory framework for the ITER project
First wall and divertor plate disposed facing to plasma of thermonuclear device
International Nuclear Information System (INIS)
Araki, Masanori; Suzuki, Satoshi; Akiba, Masato; Hayata, Yoshiho; Inoue, Taiji; Hayashi, Yukihiro; Kude, Yukinori
1998-01-01
In order to make the most of characteristics of each ingredient of carbon fiber-reinforced composite materials, carbon fiber unidirectionally reinforced materials and a carbon fiber three-directionally reinforced material are laminated in the direction of the thickness to form a carbon fiber-reinforced carbon composite material. In this case, the carbon fibers are continuously oriented in the direction of the thickness to constitute the carbon fiber reinforced carbon composite materials integrally. In addition, a carbon fiber-reinforced carbon composite material prepared by bonding a metal on one surface in adjacent with the unidirectional carbon fiber reinforced portion and substantially in perpendicular to the direction of the thickness of the unidirectional carbon fiber reinforced portion is used as a main constitutional material. Further, a metal tube is buried in the carbon fiber three-directionally reinforced carbon composite material. Then, a first wall and a divertor plate excellent in thermal impact resistance to be disposed facing to plasmas of a thermonuclear device can be provided. (N.H.)
International Nuclear Information System (INIS)
Henning, C.D.; Gilleland, J.R.
1988-01-01
The Tokamak Ignition/Burn Experimental Reactor (TIBER) was pursued in the US as one option for an International Thermonuclear Experimental Reactor (ITER). This concept evolved from earlier work on the Tokamak Fusion Core Experiment (TFCX) to develop a small, ignited tokamak. While the copper-coil versions of TFCX became the short-pulsed, 1.23-m radius, Compact Ignition Tokamak (CIT), the superconducting TIBER with long pulse or steady state and a 2.6-m radius was considered for international collaboration. Recently the design was updated to TIBER II, to accommodate more conservative confinement scaling, double-poloidal divertors for impurity control, steady-state current drive, and nuclear testing. 18 refs., 1 fig
Towards a new generation of control and data acquisition systems for thermonuclear fusion research
International Nuclear Information System (INIS)
Van Haren, P.C.
1993-01-01
Because of the complexity of thermonuclear fusion test reactors, control systems are indispensable. The physical properties of the reactor medium, i.e. the plasma, are still not well understood. Therefore, many diagnostic techniques are applied to investigate the plasma and to discover its properties. As a consequence, data acquisition systems play an important role in thermonuclear fusion research. This thesis reports on three projects that were carried out in the field of control and data acquisition. The target experiment is the Rijnhuizen Tokamak Project (RTP), a medium-sized experiment dedicated to studies of transport in the reactor medium. One of the projects is aimed at the development of a new Plasma Position and Current Control feedback System (PPCCS). This system evaluates signals of a large (about 20) number of sensors, computes the actual state of the plasma from these signals and generates command signals for the power supplies that govern the plasma position. The most ambitious project described in this thesis is the development of a data acquisition system, called TRAMP (Transient Recorders and Amoeba Multi Processor), that aims to be a testbed for smart data acquisition strategies. TRAMP attempts to acquire and store temporarily all possible data at a high sampling frequency from a single RTP pulse, and accommodates for a resampling in software prior to transferring the data to a mass storage facility. The software resampling frequency can be tuned by analysis of the acquired data and, in that way, only interesting data will be stored. In the course of the development of both the above-mentioned systems it turned out that the existing database format applied for managing experimental data provided many hurdles in the realization of efficient solutions. Consequently, a new database format was developed together with software to deal with it. This new database, called DOM4 (Data Organization and Management), is now applied at all data acquisition
International Nuclear Information System (INIS)
Strickler, D.J.; Galambos, J.D.; Peng, Y.K.M.
1989-03-01
Two versions of the Fusion Engineering Design Center (FEDC) free-boundary equilibrium code designed to computer the poloidal field (PF) coil current distribution of elongated, magnetically limited tokamak plasmas are demonstrated and applied to the systems analysis of the impact of plasma elongation on the design point of the International Thermonuclear Experimental Reactor (ITER). These notes were presented at the ITER Specialists' Meeting on the PF Coil System and Operational Scenario, held at the Max Planck Institute for Plasma Physics in Garching, Federal Republic of Germany, May 24--27, 1988. 8 refs., 6 figs., 4 tabs
Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility
Directory of Open Access Journals (Sweden)
Guangyuan Chen
2015-05-01
Full Text Available Large-scale genome-wide association studies (GWAS have revealed that rs10757278 polymorphism (or its proxy rs1333049 on chromosome 9p21 is associated with myocardial infarction (MI susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR = 1.29, 95% confidence interval (CI 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.
Predicting pKa for proteins using COSMO-RS
DEFF Research Database (Denmark)
Andersson, Martin Peter; Jensen, Jan Halborg; Stipp, Susan Louise Svane
2013-01-01
We have used the COSMO-RS implicit solvation method to calculate the equilibrium constants, pKa, for deprotonation of the acidic residues of the ovomucoid inhibitor protein, OMTKY3. The root mean square error for comparison with experimental data is only 0.5 pH units and the maximum error 0.8 p......H units. The results show that the accuracy of pKa prediction using COSMO-RS is as good for large biomolecules as it is for smaller inorganic and organic acids and that the method compares very well to previous pKa predictions of the OMTKY3 protein using Quantum Mechanics/Molecular Mechanics. Our approach...
Directory of Open Access Journals (Sweden)
Qiang Lou
2014-01-01
Full Text Available Staphylococcus epidermidis, which is a causative pathogen of nosocomial infection, expresses its virulent traits such as biofilm and autolysis regulated by two-component signal transduction system SaeRS. In this study, we performed a proteomic analysis of differences in expression between the S. epidermidis 1457 wild-type and saeRS mutant to identify candidates regulated by saeRS using two-dimensional gel electrophoresis (2-DE combined with matrix-assisted laser desorption/lonization mass spectrometry (MALDI-TOF-MS. Of 55 identified proteins that significantly differed in expression between the two strains, 15 were upregulated and 40 were downregulated. The downregulated proteins included enzymes related to glycolysis and TCA cycle, suggesting that glucose is not properly utilized in S. epidermidis when saeRS was deleted. The study will be helpful for treatment of S. epidermidis infection from the viewpoint of metabolic modulation dependent on two-component signal transduction system SaeRS.
International Nuclear Information System (INIS)
Fisker, J; Tan, W; Goerres, J; Wiescher, M; Cooper, R
2007-01-01
Neutron stars in close binary star systems often accrete matter from their companion stars. Thermonuclear ignition of the accreted material in the atmosphere of the neutron star leads to a thermonuclear explosion which is observed as an X-ray burst occurring periodically between hours and days depending on the accretion rate. The ignition conditions are characterized by a sensitive interplay between the accretion rate of the fuel supply and its depletion rate by nuclear burning in the hot CNO cycle and the rp-process. For accretion rates close to stable burning the burst ignition therefore depends critically on the hot CNO breakout reaction 15 O(α, γ) 19 Ne that regulates the flow between the hot CNO cycle and the rapid proton capture process. Until recently, the 15 O(α, γ) 19 Ne reaction rate was not known experimentally and the theoretical estimates carried significant uncertainties. In this paper we perform a parameter study of the uncertainty of this reaction rate and determine the astrophysical consequences of the first measurement of this reaction rate. Our results corroborate earlier predictions and show that theoretically burning remains unstable up to accretion rates near the Eddington limit, in contrast to astronomical observations
Soft-decision decoding of RS codes
DEFF Research Database (Denmark)
Justesen, Jørn
2005-01-01
By introducing a few simplifying assumptions we derive a simple condition for successful decoding using the Koetter-Vardy algorithm for soft-decision decoding of RS codes. We show that the algorithm has a significant advantage over hard decision decoding when the code rate is low, when two or more...
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African Journals Online (AJOL)
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Simple model for taking into account the effects of plasma screening in thermonuclear reactions
International Nuclear Information System (INIS)
Shalybkov, D.A.; Yakovlev, D.G.
1988-01-01
In the Thomas-Fermi model of high-density matter analytic calculation is made of the factor by which the rate of the thermonuclear reactions is enhanced by the effects of plasma screening in a degenerate weakly non-ideal electron gas and a strongly nonideal two-component ion liquid with large charge of the ions. The regions of densities and temperatures in which screening due to compressibility of the electron gas plays an important part are found. It is noted that the screening due to this compressibility may be influenced by strong magnetic fields B /approximately/ 10 12 -10 13 G, which quantize the motion of the electrons and change the electron charge screening length in the plasma. The results can be used for the degenerate cores of white dwarfs and shells of neutron stars
International Nuclear Information System (INIS)
Gibson, C.R.; Miller, J.R.
1988-01-01
This paper analyzes the effect of transverse loading on a cable-in-conduit conductor which has been proposed for the toroidal field coils of the International Thermonuclear Experimental Reactor. The primary components of this conductor are a loose cable of superconducting wires, a thin-wall tube for helium containment, and a U-shaped structural channel. A method is given where the geometry of this conductor can be optimized for a given set of operating conditions. It is shown, using finite-element modeling, that the structural channel is effective in supporting loads due to transverse forces and internal pressure. In addition, it is shown that the superconducting cable is effectively shielded from external transverse loads that might otherwise degrade its current carrying capacity. 10 refs., 10 figs., 3 tabs
International Nuclear Information System (INIS)
Shannon, T.E.
1990-01-01
The International Thermonuclear Experimental Reactor (ITER) project is expected to fully confirm the scientific feasibility and to address the technological feasibility of fusion power. Consequently, the machine must be designed for controlled ignition and extended burn of deuterium-tritium plasma. It must also demonstrate and perform integrated testing of components required to utilize fusion power for practical purposes. Cooperation among four countries/organizations (United States, Soviet Union, Japan, and EURATOM) to build a single experimental reactor will reduce the cost for each country and provide an international pool of scientific and engineering resources. This paper describes ITER organization for conceptual design activity, schedule for conceptual design activities, ITER operating parameters, conceptual project schedule and cost, future plans, basic principles and problems related to task sharing, and basic principles in handling of intellectual property
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A.S. Gudz
2017-10-01
Full Text Available Background. A key factor of neoangiogenesis development in diabetic retinopathy (DR among patients with type 2 diabetes mellitus (DM is vascular endothelial growth factor A (VEGFA. The important role of genetic polymorphisms of the VEGFA gene indicates a number of studies and meta-analyzes, that have shown their association with DR, especially with its proliferative variant, which varies in different populations. Accordingly, the purpose of this work was to find out the influence of the polymorphic genotypes rs2010963 and rs699947 of the VEGFA gene on clinical and laboratory parameters of DR in DM patients from Ukrainian population. Materials and methods. The study involved 302 patients with type 2 diabetes mellitus and DR. Diagnosis was established according to the international clinical classification adopted by the American Academy of Ophthalmology (2003. The control group consisted of 98 people who did not have DM and DR, as well as other ophthalmic diseases. All patients were operated on cataract. In the intraocular fluid collected during the surgery, the VEGFA content was determined by the immunoassay method. Analysis of the polymorphic DNA loci of the VEGFA gene: rs2010963 and rs699947 was performed in a real time polymerase chain reaction using TaqMan Mutation Detection Assays (Thermo Fisher Scientific, USA. Results. An analysis of the study results showed that rs2010963 polymorphism had an effect on the intraocular fluid VEGFA level (maximum — under the C/C risk genotype. This polymorphism was related to the sex (the genotype C/C was more common in men than in women: 3 : 1, the presence of proliferative DR (most often was determined by the presence of the genotype C/C: 45.4 % and neovascularization of the optic disc (most often determined by the presence of heterozygotes G/C: 21.4 %. Polymorphism rs699947 had an effect on the visual acuity (the minimum was available in the genotype C/C, the thickness of the retina (the maximum
Divertor impurity monitor for the International Thermonuclear Experimental Reactor
Sugie, T.; Ogawa, H.; Nishitani, T.; Kasai, S.; Katsunuma, J.; Maruo, M.; Ebisawa, K.; Ando, T.; Kita, Y.
1999-01-01
The divertor impurity monitoring system of the International Thermonuclear Experimental Reactor has been designed. The main functions of this system are to identify impurity species and to measure the two-dimensional distributions of the particle influxes in the divertor plasmas. The wavelength range is 200-1000 nm. The viewing fans are realized by molybdenum mirrors located in the divertor cassette. With additional viewing fans seeing through the gap between the divertor cassettes, the region approximately from the divertor leg to the x point will be observed. The light from the divertor region passes through the quartz windows on the divertor port plug and the cryostat, and goes through the dog-leg optics in the biological shield. Three different type of spectrometers: (i) survey spectrometers for impurity species monitoring, (ii) filter spectrometers for the particle influx measurement with the spatial resolution of 10 mm and the time resolution of 1 ms, and (iii) high dispersion spectrometers for high resolution wavelength measurements are designed. These spectrometers are installed just behind the biological shield (for λthe transmission loss in fiber and in the diagnostic room (for λ⩾450 nm) from the point of view of accessibility and flexibility. The optics have been optimized by a ray trace analysis. As a result, 10-15 mm spatial resolution will be achieved in all regions of the divertor.
2011-01-01
Background Staphylococcus epidermidis (SE) has emerged as one of the most important causes of nosocomial infections. The SaeRS two-component signal transduction system (TCS) influences virulence and biofilm formation in Staphylococcus aureus. The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear. Results The saeRS genes of SE1457 were deleted by homologous recombination. The saeRS deletion mutant, SE1457ΔsaeRS, exhibited increased biofilm formation that was disturbed more severely (a 4-fold reduction) by DNase I treatment compared to SE1457 and the complementation strain SE1457saec. Compared to SE1457 and SE1457saec, SE1457ΔsaeRS showed increased Triton X-100-induced autolysis (approximately 3-fold) and decreased cell viability in planktonic/biofilm states; further, SE1457ΔsaeRS also released more extracellular DNA (eDNA) in the biofilms. Correlated with the increased autolysis phenotype, the transcription of autolysis-related genes, such as atlE and aae, was increased in SE1457ΔsaeRS. Whereas the expression of accumulation-associated protein was up-regulated by 1.8-fold in 1457ΔsaeRS, the expression of an N-acetylglucosaminyl transferase enzyme (encoded by icaA) critical for polysaccharide intercellular adhesin (PIA) synthesis was not affected by the deletion of saeRS. Conclusions Deletion of saeRS in S. epidermidis resulted in an increase in biofilm-forming ability, which was associated with increased eDNA release and up-regulated Aap expression. The increased eDNA release from SE1457ΔsaeRS was associated with increased bacterial autolysis and decreased bacterial cell viability in the planktonic/biofilm states. PMID:21702925
Directory of Open Access Journals (Sweden)
Francois Patrice
2011-06-01
Full Text Available Abstract Background Staphylococcus epidermidis (SE has emerged as one of the most important causes of nosocomial infections. The SaeRS two-component signal transduction system (TCS influences virulence and biofilm formation in Staphylococcus aureus. The deletion of saeR in S. epidermidis results in impaired anaerobic growth and decreased nitrate utilization. However, the regulatory function of SaeRS on biofilm formation and autolysis in S. epidermidis remains unclear. Results The saeRS genes of SE1457 were deleted by homologous recombination. The saeRS deletion mutant, SE1457ΔsaeRS, exhibited increased biofilm formation that was disturbed more severely (a 4-fold reduction by DNase I treatment compared to SE1457 and the complementation strain SE1457saec. Compared to SE1457 and SE1457saec, SE1457ΔsaeRS showed increased Triton X-100-induced autolysis (approximately 3-fold and decreased cell viability in planktonic/biofilm states; further, SE1457ΔsaeRS also released more extracellular DNA (eDNA in the biofilms. Correlated with the increased autolysis phenotype, the transcription of autolysis-related genes, such as atlE and aae, was increased in SE1457ΔsaeRS. Whereas the expression of accumulation-associated protein was up-regulated by 1.8-fold in 1457ΔsaeRS, the expression of an N-acetylglucosaminyl transferase enzyme (encoded by icaA critical for polysaccharide intercellular adhesin (PIA synthesis was not affected by the deletion of saeRS. Conclusions Deletion of saeRS in S. epidermidis resulted in an increase in biofilm-forming ability, which was associated with increased eDNA release and up-regulated Aap expression. The increased eDNA release from SE1457ΔsaeRS was associated with increased bacterial autolysis and decreased bacterial cell viability in the planktonic/biofilm states.
Mass and Reliability System (MaRS)
Barnes, Sarah
2016-01-01
The Safety and Mission Assurance (S&MA) Directorate is responsible for mitigating risk, providing system safety, and lowering risk for space programs from ground to space. The S&MA is divided into 4 divisions: The Space Exploration Division (NC), the International Space Station Division (NE), the Safety & Test Operations Division (NS), and the Quality and Flight Equipment Division (NT). The interns, myself and Arun Aruljothi, will be working with the Risk & Reliability Analysis Branch under the NC Division's. The mission of this division is to identify, characterize, diminish, and communicate risk by implementing an efficient and effective assurance model. The team utilizes Reliability and Maintainability (R&M) and Probabilistic Risk Assessment (PRA) to ensure decisions concerning risks are informed, vehicles are safe and reliable, and program/project requirements are realistic and realized. This project pertains to the Orion mission, so it is geared toward a long duration Human Space Flight Program(s). For space missions, payload is a critical concept; balancing what hardware can be replaced by components verse by Orbital Replacement Units (ORU) or subassemblies is key. For this effort a database was created that combines mass and reliability data, called Mass and Reliability System or MaRS. The U.S. International Space Station (ISS) components are used as reference parts in the MaRS database. Using ISS components as a platform is beneficial because of the historical context and the environment similarities to a space flight mission. MaRS uses a combination of systems: International Space Station PART for failure data, Vehicle Master Database (VMDB) for ORU & components, Maintenance & Analysis Data Set (MADS) for operation hours and other pertinent data, & Hardware History Retrieval System (HHRS) for unit weights. MaRS is populated using a Visual Basic Application. Once populated, the excel spreadsheet is comprised of information on ISS components including
Energy Technology Data Exchange (ETDEWEB)
Marsteen, L.
1996-02-01
Norwegian Institute for Air Research (NILU) has, as a part of the quality control systems, developed an automatic system of data recording. This report describes the installation and use of the RsComm software. Using RsComm and a NILU data recorder it is possible to run system tests on air quality analyzers via a telephone line. Test reports are generated. 17 figs.
THREE-DIMENSIONAL DOPPLER TOMOGRAPHY OF THE RS VULPECULAE INTERACTING BINARY
International Nuclear Information System (INIS)
Richards, Mercedes T.; Sharova, Olga I.; Agafonov, Michail I.
2010-01-01
Three-dimensional Doppler tomography has been used to study the Hα emission sources in the RS Vulpeculae (RS Vul) interacting binary. The two-dimensional tomogram of this binary suggested that most of the emission arises from the cool mass losing star with additional evidence of a gas stream flowing close to its predicted trajectory. However, the three-dimensional tomogram revealed surprising evidence that the gas stream has an average velocity of -85 km s -1 relative to the central velocity plane at V z = 0 km s -1 , unlike U CrB in which the stream was prominent along this central plane. These unexpected V z motions may result from the interaction between magnetic activity on the cool star and the gravitationally induced Roche lobe overflow from that star. Evidence of a loop prominence on the cool star close to the L1 point has been found in the three-dimensional tomogram of RS Vul; hence, the magnetic field lines may have deflected the gas stream relative to the central plane. This result is consistent with earlier detections of RS Vul as both an X-ray and a radio source, and represents the first detection of a loop prominence in an interacting binary based on tomography. Moreover, recent radio images of β Per, the prototype of the Algols, show that the magnetic field of the mass losing star is asymmetric and extends well beyond the orbital plane of the binary, so it is now plausible that the gas flow between the stars in RS Vul could be deflected in an asymmetric way by the magnetic field.
Crosstalk XVI, basic data communication and RS-232C
International Nuclear Information System (INIS)
Hwang, Hui Yung
1988-10-01
This book is divided into three parts, which deals with compatible software of data communication with IBM PC XT/AT. The first part consists of an introduction to crosstalk XVI, getting start for user, crosstalk practice, call with crosstalk, terminal feature, switch of communication parameter, terminal emulation, capturing data, transmission of text file answer mode, file transfer, command file and script file, command summary and examples. The second part deals with basic personal computer communication, RS-232C and explanation of communication control : RS-232C interface, transmission device and interrupt controller 8259.
Tokamak nonmaxwellian plasma dynamics in thermonuclear regime
International Nuclear Information System (INIS)
Cotsaftis, M.
1987-01-01
To reach ignition in a Tokamak plasma, large additional power P aux has to be injected in the device on top of the Joule heating P OH =VI r , V the plasma loop voltage, I r the resistive port of plasma current. Typi-cally JH ∼ 1 KeV, whereas ignition would requi- re IG ∼ 7-10 KeV. To gain this factor 7, one at least should inject additional power P aux ∼ 7P OH , supposing that nothing, especially the heat transport, is modified. This is by far not the case, with the so-called energy lifetime degradation, largely observed in oil experiments (but less dramatic with divertors), where energy lifetime tau E behaves like P tot -b with b∼1/2. In large machines where ignition temperature is the target to be imperiously reached, this implies to inject a very large power, typically P aux ∼ 50 to 100 MW, depending on size and parameters and on actual transport. So it is of importance with such figures, or even larger ones owing to uncertain ties, to optimize at best injected power by increasing its efficiency, both with respect to possible transport laws, and to physical phenomena governing heat flow in the system from the sources. This leads to the concept of scenarios, as time sequences of power input, where physical properties of the plasma system are used to build up ion temperature so that ignition is reached with minimum P tot = P OH + P aux and with fixed Q = Q o > 1. Elements for this study are given. The method is outlined. The resulting system of equations describing the evolution of a thermonuclear plasma is given
Parallel data grabbing card based on PCI bus RS422
International Nuclear Information System (INIS)
Zhang Zhenghui; Shen Ji; Wei Dongshan; Chen Ziyu
2005-01-01
This article briefly introduces the developments of the parallel data grabbing card based on RS422 and PCI bus. It could be applied for grabbing the 14 bits parallel data in high speed, coming from the devices with RS422 interface. The methods of data acquisition which bases on the PCI protocol, the functions and their usages of the chips employed, the ideas and principles of the hardware and software designing are presented. (authors)
Polymorphisms of Interlukin-1β rs16944 confer susceptibility to myelodysplastic syndromes.
Yin, Congcong; He, Na; Li, Peng; Zhang, Chen; Yu, Jie; Hua, Mingqiang; Ji, Chunyan; Ma, Daoxin
2016-11-15
Genetic factors have been shown to be associated with Myelodysplastic syndromes (MDS) susceptibility. In recent years, the role of inflammation in the promotion of tumor growth is supported by a broad range of experimental and clinical evidence. But the relationship between polymorphisms in NOD-like receptor protein 3 (NLRP3) inflammasome and MDS is rarely reported. Thus, we conducted a case-control study, and genotyped five single nucleotide polymorphisms (SNPs) (NLRP3, IL-1β, IL-18, CARD8, and NF-κB) in MDS patients and healthy controls. The association of different genotypes with patient characteristics was analyzed. Comparing MDS patients with controls, GG genotype of IL-1β (rs16944) was observed to be associated with a significantly increased risk of MDS 78/166 (48.8%) vs 26/96 (27.0%), OR=2.1, CI (1.0-4.4). No significant association was identified regarding the rest of investigated polymorphisms and MDS susceptibility. Complex karyotypes were more frequent in patients with GG genotype of IL-1β (rs16944). Patients with IL-1β polymorphisms (rs16944) GG and GA had lower hemoglobin than those without. Patients with IL-1β polymorphisms (rs16944) GG had higher IPSS scores than those without IL-1β polymorphisms. In conclusion, our present data shows that the IL-1β polymorphisms (rs16944) GG were frequently occurred in MDS. IL-1β (rs16944) GG genotype might serve as a novel biomarker and potential targets for MDS. Copyright © 2016 Elsevier Inc. All rights reserved.
Thermonuclear Tokamak plasmas in the presence of fusion alpha particles
International Nuclear Information System (INIS)
Anderson, D.; Hamnen, H.; Lisak, M.
1988-01-01
In this overview, we have focused on several results of the thermonuclear plasma research pertaining to the alpha particle physics and diagnostics in a fusion tokamak plasma. As regards the discussion of alpha particle effects, two distinct classes of phenomena have been distinguished: the simpler class containing phenomena exhibited by individual alpha particles under the influence of bulk plasma properties and, the more complex class including collective effects which become important for increasing alpha particle density. We have also discussed several possibilities to investigate alpha particle effects by simulation experiments using an equivalent population of highly energetic ions in the plasma. Generally, we find that the present theoretical knowledge on the role of fusion alpha particles in a fusion tokamak plasma is incomplete. There are still uncertainties and partial lack of quantitative results in this area. Consequently, further theoretical work and, as far a possible, simulation experiments are needed to improve the situation. Concerning the alpha particle diagnostics, the various diagnostic techniques and the status of their development have been discussed in two different contexts: the escaping alpha particles and the confined alpha particles in the fusion plasma. A general conclusion is that many of the different diagnostic methods for alpha particle measurements require further major development. (authors)
International Nuclear Information System (INIS)
Rodrigues, George; Lukka, Himu; Warde, Padraig; Brundage, Michael; Souhami, Luis; Crook, Juanita; Cury, Fabio; Catton, Charles; Mok, Gary; Martin, Andre-Guy; Vigneault, Eric; Morris, Jim; Warner, Andrew; Gonzalez Maldonado, Sandra; Pickles, Tom
2013-01-01
Background: The Genitourinary Radiation Oncologists of Canada (GUROC) published a three-group risk stratification (RS) system to assist prostate cancer decision-making in 2001. The objective of this project is to use the ProCaRS database to statistically model the predictive accuracy and clinical utility of a proposed new multi-group RS schema. Methods: The RS analyses utilized the ProCaRS database that consists of 7974 patients from four Canadian institutions. Recursive partitioning analysis (RPA) was utilized to explore the sub-stratification of groups defined by the existing three-group GUROC scheme. 10-fold cross-validated C-indices and the Net Reclassification Index were both used to assess multivariable models and compare the predictive accuracy of existing and proposed RS systems, respectively. Results: The recursive partitioning analysis has suggested that the existing GUROC classification system could be altered to accommodate as many as six separate and statistical unique groups based on differences in BFFS (C-index 0.67 and AUC 0.70). GUROC low-risk patients would be divided into new favorable-low and low-risk groups based on PSA ⩽6 and PSA >6. GUROC intermediate-risk patients can be subclassified into low-intermediate and high-intermediate groups. GUROC high-intermediate-risk is defined as existing GUROC intermediate-risk with PSA >=10 AND either T2b/c disease or T1T2a disease with Gleason 7. GUROC high-risk patients would be subclassified into an additional extreme-risk group (GUROC high-risk AND (positive cores ⩾87.5% OR PSA >30). Conclusions: Proposed RS subcategories have been identified by a RPA of the ProCaRS database
Infrared observations of RS CVn stars
Berriman, G.; De Campli, W. M.; Werner, M. W.; Hatchett, S. P.
1983-01-01
The paper presents infrared photometry of the RS CVn binary stars AR Lac (1.2-10 microns) and MM Her (1.2-3.5 microns) as they egressed from their primary and secondary eclipses; of the eclipsing systems RS CVn and Z Her at maximum light (1.2-10 microns) and of the non-eclipsing systems UX Ari and HR 1099 (1.2-10 microns). An analysis of these and published V data based on flux ratio diagrams (linear analogues of color-color diagrams) shows that G and K stars supply the infrared light of these systems. In AR Lac, the combined light of a G5-K0 subgiant and either a late F dwarf or an early F subgiant can account for the observed visual and infrared light curves. None of these systems shows infrared emission from circumstellar matter. This result is simply understood: dust grains would not be expected to form in the physical conditions surrounding the subgiant, and the corona and chromosphere (whose properties have been deduced from spectroscopic X-ray observations) should not produce appreciable infrared emission.
Working in partnership to advance the 3Rs in toxicity testing
International Nuclear Information System (INIS)
Holmes, Anthony M.; Creton, Stuart; Chapman, Kathryn
2010-01-01
Toxicological assessment of pharmaceutical and non-pharmaceutical chemicals is a regulatory requirement to ensure all compounds likely to be exposed to humans or the environment are safe. These studies rely on the use of large numbers of animals and involve a number of assumptions and extrapolations that remain controversial in assuring consumer safety. The UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) has taken a collaborative approach to identify opportunities for implementation of the 3Rs principles (Replacement, Reduction and Refinement) to drive innovation and support animal welfare in toxicity testing. This review highlights the mechanisms by which the NC3Rs is working with the pharmaceutical and chemical industries and regulatory authorities to achieve these goals.
PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population
Villalobos-Comparán, Marisela; Villamil-Ramírez, Hugo; Villarreal-Molina, Teresa; Larrieta-Carrasco, Elena; León-Mimila, Paola; Romero-Hidalgo, Sandra; Jacobo-Albavera, Leonor; Liceaga-Fuentes, Adriana E.; Campos-Pérez, Francisco J.; López-Contreras, Blanca E.; Tusié-Luna, Teresa; del Río-Navarro, Blanca E.; Aguilar-Salinas, Carlos A.; Canizales-Quinteros, Samuel
2012-01-01
Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64–5.53; P = 4×10−4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. PMID:22737226
Memmi, Guido; Nair, Dhanalakshmi R; Cheung, Ambrose
2012-02-01
Autolysis plays an essential role in bacterial cell division and lysis with β-lactam antibiotics. Accordingly, the expression of autolysins is tightly regulated by several endogenous regulators, including ArlRS, a two component regulatory system that has been shown to negatively regulate autolysis in methicillin-sensitive Staphylococcus aureus (MSSA) strains. In this study, we found that inactivation of arlRS does not play a role in autolysis of methicillin-resistant S. aureus (MRSA) strains, such as community-acquired (CA)-MRSA strains USA300 and MW2 or the hospital-acquired (HA)-MRSA strain COL. This contrasts with MSSA strains, including Newman, SH1000, RN6390, and 8325-4, where autolysis is affected by ArlRS. We further demonstrated that the striking difference in the roles of arlRS between MSSA and MRSA strains is not due to the methicillin resistance determinant mecA. Among known autolysins and their regulators, we found that arlRS represses lytN, while no effect was seen on atl, lytM, and lytH expression in both CA- and HA-MRSA strains. Transcriptional-fusion assays showed that the agr transcripts, RNAII and RNAIII, were significantly more downregulated in the arlRS mutant of MW2 than the MSSA strain Newman. Importantly, provision of agr RNAIII in trans to the MW2 arlRS mutant via a multicopy plasmid induced autolysis in this MRSA strain. Also, the autolytic phenotype in the arlRS mutant of MSSA strain Newman could be rescued by a mutation in either atl or lytM. Together, these data showed that ArlRS impacts autolysis differently in MSSA and MRSA strains.
THE HISTORY OF LABORATORY ANIMALS AND THE 3RS
DEFF Research Database (Denmark)
Alstrup, Aage Kristian Olsen
This talk will give an introduction to the history of the use of laboratory animals with focus on the history of the three Rs (3Rs). We will see how animal experimentation has been performed early in our civilization, and how the suffering of animals has been justified. This will include Rene...... Descartes´s mechanical view of animals in the seventeenth century, and Charles Darwin's ambivalent relationship to animal experimentation, which he views as cruel but necessary. In the 1870s the Danish Foundation for Protection of Animals (“Dyrenes Beskyttelse”) and Professor Peter Panum discussed the use...
Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.
Sakiyama, Masayuki; Matsuo, Hirotaka; Nakaoka, Hirofumi; Yamamoto, Ken; Nakayama, Akiyoshi; Nakamura, Takahiro; Kawai, Sayo; Okada, Rieko; Ooyama, Hiroshi; Shimizu, Toru; Shinomiya, Nariyoshi
2016-05-16
Gout is a common disease resulting from hyperuricemia. Recently, a genome-wide association study identified an association between gout and a single nucleotide polymorphism (SNP) rs2188380, located on an intergenic region between MYL2 and CUX2 on chromosome 12. However, other genes around rs2188380 could possibly be gout susceptibility genes. Therefore, we performed a fine-mapping study of the MYL2-CUX2 region. From 8,595 SNPs in the MYL2-CUX2 region, 9 tag SNPs were selected, and genotyping of 1,048 male gout patients and 1,334 male controls was performed by TaqMan method. Eight SNPs showed significant associations with gout after Bonferroni correction. rs671 (Glu504Lys) of ALDH2 had the most significant association with gout (P = 1.7 × 10(-18), odds ratio = 0.53). After adjustment for rs671, the other 8 SNPs no longer showed a significant association with gout, while the significant association of rs671 remained. rs671 has been reportedly associated with alcohol drinking behavior, and it is well-known that alcohol drinking elevates serum uric acid levels. These data suggest that rs671, a common functional SNP of ALDH2, is a genuine gout-associated SNP in the MYL2-CUX2 locus and that "A" allele (Lys) of rs671 plays a protective role in the development of gout.
Cleaning and air conditioning device for atmosphere in thermonuclear reactor chamber
International Nuclear Information System (INIS)
Ishida, Seiji.
1993-01-01
The device of the present invention removes tritium efficiently and attains ventilation and conditioning of a great amount of air flow. That is, there are disposed a humidity separator, a filter, a heater, a catalyst filled layer, a water jetting type humidifying heat insulation cooler and a cooler in this order from an inlet side (upstream) of contaminated room atmospheric gases. The catalyst filled layer, etc. are incorporated integrally into the ventilation air conditioning facility for ventilating air in the chamber of the thermonuclear reactor, to clean a tritium atmosphere at the same time. Accordingly, the device is made compact as a whole. A limit for the air flow rate owing to the use of the conventional catalyst tower and adsorbing tower is eliminated. Then a ventilating air conditioning for a great flow rate can be attained. Tritium is removed by cooling and dehumidification without using any adsorbent. Accordingly, an adsorbing tower is no more necessary and conventional regeneration operation is not required. As a result, space for installation is reduced, the system is simplified and the cost for construction and facility can be reduced. (I.S.)
Dust processing device for inside of vacuum vessel of thermonuclear reactor
Energy Technology Data Exchange (ETDEWEB)
Okumura, Atsushi; Tsujimura, Seiichi; Takahashi, Kenji; Ueda, Yasutoshi; Kuwata, Masayasu; Onozuka, Masaki
1995-05-02
The device of the present invention can occasionally recover dusts in a vacuum vessel of a thermonuclear reactor. In addition, fine powdery dusts are never scattered to the vacuum vessel. Namely, a processing device main body comprises a locally sealed space in the vacuum vessel. A blow-up device blows up and floats dusts accumulated in the vacuum vessel to the processing device main body. A discharge plate electrically charges the floating dusts by discharge. An electrode collects the charged dusts. Collected dusts are recovered together with a pressurized gas through a dust recovering port to the outside of the processing device. With such a constitution, it is not necessary to release the vacuum vessel to the atmosphere and evacuate after the completion of the collection of the dusts on every time when the dusts are generated as in the prior art. It is no more necessary for an operator to enter into the vacuum vessel and recover the dusts. Since fine powdery dusts are never scattered in the vacuum vessel, no undesired effects are given to exhaustion facilities and instruments of the vacuum vessel. (I.S.).
Dust processing device for inside of vacuum vessel of thermonuclear reactor
International Nuclear Information System (INIS)
Okumura, Atsushi; Tsujimura, Seiichi; Takahashi, Kenji; Ueda, Yasutoshi; Kuwata, Masayasu; Onozuka, Masaki.
1995-01-01
The device of the present invention can occasionally recover dusts in a vacuum vessel of a thermonuclear reactor. In addition, fine powdery dusts are never scattered to the vacuum vessel. Namely, a processing device main body comprises a locally sealed space in the vacuum vessel. A blow-up device blows up and floats dusts accumulated in the vacuum vessel to the processing device main body. A discharge plate electrically charges the floating dusts by discharge. An electrode collects the charged dusts. Collected dusts are recovered together with a pressurized gas through a dust recovering port to the outside of the processing device. With such a constitution, it is not necessary to release the vacuum vessel to the atmosphere and evacuate after the completion of the collection of the dusts on every time when the dusts are generated as in the prior art. It is no more necessary for an operator to enter into the vacuum vessel and recover the dusts. Since fine powdery dusts are never scattered in the vacuum vessel, no undesired effects are given to exhaustion facilities and instruments of the vacuum vessel. (I.S.)
SparkRS - Spark for Remote Sensing, Phase I
National Aeronautics and Space Administration — The proposed innovation is Spark-RS, an open source software project that enables GPU-accelerated remote sensing workflows in an Apache Spark distributed computing...
Bufalo, N E; Dos Santos, R B; Marcello, M A; Piai, R P; Secolin, R; Romaldini, J H; Ward, L S
2015-05-01
Intronic thyroid-stimulating hormone receptor polymorphisms have been associated with the risk for both Graves' disease and Graves' ophthalmopathy, but results have been inconsistent among different populations. We aimed to investigate the influence of thyroid-stimulating hormone receptor intronic polymorphisms in a large well-characterized population of GD patients. We studied 279 Graves' disease patients (231 females and 48 males, 39.80 ± 11.69 years old), including 144 with Graves' ophthalmopathy, matched to 296 healthy control individuals. Thyroid-stimulating hormone receptor genotypes of rs179247 and rs12885526 were determined by Real Time PCR TaqMan(®) SNP Genotyping. A multivariate analysis showed that the inheritance of the thyroid-stimulating hormone receptor AA genotype for rs179247 increased the risk for Graves' disease (OR = 2.821; 95 % CI 1.595-4.990; p = 0.0004), whereas the thyroid-stimulating hormone receptor GG genotype for rs12885526 increased the risk for Graves' ophthalmopathy (OR = 2.940; 95 % CI 1.320-6.548; p = 0.0083). Individuals with Graves' ophthalmopathy also presented lower mean thyrotropin receptor antibodies levels (96.3 ± 143.9 U/L) than individuals without Graves' ophthalmopathy (98.3 ± 201.9 U/L). We did not find any association between the investigated polymorphisms and patients clinical features or outcome. We demonstrate that thyroid-stimulating hormone receptor intronic polymorphisms are associated with the susceptibility to Graves' disease and Graves' ophthalmopathy in the Brazilian population, but do not appear to influence the disease course.
A conceptual design of the International Thermonuclear Experimental Reactor for the Central Solenoid
International Nuclear Information System (INIS)
Heim, J.R.; Parker, J.M.
1990-01-01
Conceptual design of the International Thermonuclear Experimental Reactor (ITER) superconducting magnet system is nearing completion by the ITER Design Team, and one of the Central Solenoid (CS) designs is presented. The CS part of this magnet system will be a vertical stack of eight modules, approximately 16 m high, each having a approximate dimensions of: 4.1-m o.d., 2.8-m i.d., 1.9-m h. The peak field at the bore is approximately 13.5 T. Cable-in-conduit conductor with Nb 3 Sn composite wire will be used to wind the coils. The overall coil fabrication will use the insulate-wind-react-impregnate method. Coil modules will be fabricated using double-pancake coils with all splice joints located in the low-field region on the outside of the coils. All coils will be structurally graded with high-strength steel reinforcement which is co-wound with the conductor. We describe details of the CS coil design and analysis
Directory of Open Access Journals (Sweden)
Irina Arkad'evna Bondar
2015-03-01
Full Text Available Aim. Sulfonylureas (SU are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM. There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219 and ABCC8 (rs757110 was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia. Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, p
Manufacturing device for vacuum vessel of thermonuclear reactor and manufacturing method therefor
International Nuclear Information System (INIS)
Yanagi, Hiroshi; Shibui, Masanao; Uchida, Takaho
1998-01-01
The present invention provides a method of manufacturing a vacuum vessel of a thermonuclear reactor with no welding deformation. Namely, there are disposed a manufacturing device comprises a welding machine equipped with a plurality of welding torches which can conduct synchronizing welding and a torch positioning mechanism for positioning the plurality of welding torches each at an optional distance. Then, both ends of a splice plate can be welded by the plurality of welding torches under synchronization. Accordingly, joining portions of sectors of a vacuum vessel can be welded in the site with no deviation of beveling at joining portions between an outer wall and an inner wall with the splice plate due to welding deformation. In addition, the welding machine is mounted on a travelling type clamping mechanism stand or a travelling type clamping mechanism. With such a constitution, since the peripheries of the joining portions on the inner wall are clamped with each other by the travelling type clamping mechanism, no angular distortion is caused in any welded portion of the outer wall. (I.S.)
Analysis and evaluation of the hydrogen risk in a thermonuclear fusion reactor
International Nuclear Information System (INIS)
Chaudron, V.; Arnould, F.; Latge, C.; Laurent, A.
2001-01-01
After a recall of the principle of controlled thermonuclear fusion, the ITER reactor project is briefly described. The integrity of the reactor must be preserved in the case of a potential explosion of the hydrogen generated inside the reactor, in order to avoid any dispersion radioactive, chemical or toxic materials in the environment. The fundamental principles of safety developed to fulfill these objectives, in particular the defense-in-depth concept, are presented. The main potential source of hydrogen production is the oxidation of beryllium, which is used as protection material in the first wall of the torus, and the accidental presence of water, as reported in several scenarios. The confinement strategy is then described with the qualification of the role of the different barriers. Finally, the hydrogen explosion risk is analyzed and evaluated with respect to the sources, to the reference envelope scenarios and to the location of hydrogen inside the ITER reactor. It appears, at the engineering stage, that the vacuum toric vessel, the discharge reservoir and the exchanger compartments are the most worrying parts. (J.S.)
International Nuclear Information System (INIS)
Tuan Anh, Nguyen; Tuyen Dao, T P; Nhan Le, N T; Mau Chien, Dang; To Hoai, Nguyen; T Chi, Nguyen; Tran, T Khai
2012-01-01
Nanospheres containing ketoprofen (Keto) and polymer eudragit RS were prepared using an emulsion solvent evaporation method. The ultrasonic probe (VCX500, vibracell) was used as a tool to disperse oil phase into aqueous phase leading to water/oil emulsion. Nanoparticles were successfully prepared and their morphologies and diameters were confirmed by transmission electron microscope (TEM) and dynamic light scattering (DLS), respectively. The result showed that particles were spherical with submicron size. The particle size was dependent on the RS concentration, emulsification tools and the types of organic solvents. For the encapsulation ability, Keto-loaded RS nanoparticle showed 9.8% of Keto in nanoparticle, which was evaluated by high-performance liquid chromatography (HPLC). Moreover, the drug release behavior of Keto-loaded eudragit RS nanoparticle was also investigated in vitro at pH 7.4 and compared to referential profenid. (paper)
Solvation quantities from a COSMO-RS equation of state
International Nuclear Information System (INIS)
Panayiotou, C.; Tsivintzelis, I.; Aslanidou, D.; Hatzimanikatis, V.
2015-01-01
Highlights: • Extension of the successful COSMO-RS model to an equation-of-state model. • Two scaling constants, obtained from atom-specific contributions. • Overall estimation of the solvation quantities and contributions. - Abstract: This work focuses on the extension of the successful COSMO-RS model of mixtures into an equation-of-state model of fluids and its application for the estimation of solvation/hydration quantities of a variety of chemical substances. These quantities include free-energies, enthalpies and entropies of hydration as well as the separate contributions to each of them. Emphasis is given on the estimation of contributions from the conformational changes of solutes upon solvation and the associated restructuring of solvent in its immediate neighborhood. COSMO-RS is a quantum-mechanics based group/segment contribution model in which the Quasi-Chemical (QC) approach is used for the description of the non-random distribution of interacting segments in the system. Thus, the equation-of-state development is done through such a QC framework. The new model will not need any adjustable parameters for the strong specific interactions, such as hydrogen bonds, since they will be provided by the quantum-mechanics based cosmo-files – a key feature of COSMO-RS model. It will need, however, one volumetric and one energy parameter per fluid, which are scaling constants or molecular descriptors of the fluid and are obtained from rather easily available data such as densities, boiling points, vapor pressures, heats of vaporization or second virial coefficients. The performance and the potential of the new equation-of-state model to become a fully predictive model are critically discussed
Characterization of novel RS1 exonic deletions in juvenile X-linked retinoschisis.
D'Souza, Leera; Cukras, Catherine; Antolik, Christian; Craig, Candice; Lee, Ji-Yun; He, Hong; Li, Shibo; Smaoui, Nizar; Hejtmancik, James F; Sieving, Paul A; Wang, Xinjing
2013-01-01
X-linked juvenile retinoschisis (XLRS) is a vitreoretinal dystrophy characterized by schisis (splitting) of the inner layers of the neuroretina. Mutations within the retinoschisis (RS1) gene are responsible for this disease. The mutation spectrum consists of amino acid substitutions, splice site variations, small indels, and larger genomic deletions. Clinically, genomic deletions are rarely reported. Here, we characterize two novel full exonic deletions: one encompassing exon 1 and the other spanning exons 4-5 of the RS1 gene. We also report the clinical findings in these patients with XLRS with two different exonic deletions. Unrelated XLRS men and boys and their mothers (if available) were enrolled for molecular genetics evaluation. The patients also underwent ophthalmologic examination and in some cases electroretinogram (ERG) recording. All the exons and the flanking intronic regions of the RS1 gene were analyzed with direct sequencing. Two patients with exonic deletions were further evaluated with array comparative genomic hybridization to define the scope of the genomic aberrations. After the deleted genomic region was identified, primer walking followed by direct sequencing was used to determine the exact breakpoints. Two novel exonic deletions of the RS1 gene were identified: one including exon 1 and the other spanning exons 4 and 5. The exon 1 deletion extends from the 5' region of the RS1 gene (including the promoter) through intron 1 (c.(-35)-1723_c.51+2664del4472). The exon 4-5 deletion spans introns 3 to intron 5 (c.185-1020_c.522+1844del5764). Here we report two novel exonic deletions within the RS1 gene locus. We have also described the clinical presentations and hypothesized the genomic mechanisms underlying these schisis phenotypes.
Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.
Lee, Young Ho; Woo, Jin-Hyun; Choi, Seong Jae; Ji, Jong Dae; Song, Gwan Gyu
2010-03-01
The aim of this study was to determine whether the rs7574865 polymorphism of STAT4 (signal transducers and activators of transcription 4) confers susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. A meta-analysis was conducted on the T allele of the STAT4 rs7574865 polymorphism in 15 studies containing 16,088 RA patients and 16,509 normal control subjects. Meta-analysis revealed an association between RA and the STAT4 rs7574865 T allele in all subjects (OR = 1.271, 95% CI = 1.197-1.350, P rs7574865 T allele was found to be significantly associated with RA in Europeans and Asians (OR = 1.300, 95% CI = 1.195-1.414, P rs7574865 polymorphism is associated with RA susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
Zhen, Jie; Huang, Xiaochen; Van Halm-Lutterodt, Nicholas; Dong, Shengqi; Ma, Weiwei; Xiao, Rong; Yuan, Linhong
2017-01-01
ApoE gene polymorphism has been reportedly associated with serum lipids and cognition. However, very few studies have explored the combined effects of ApoE gene polymorphism and gender on serum lipid profile with subsequent impacts on cognition in Chinese population. A total of 1,000 Chinese community dwellers aged 55 years and above were recruited in this cross-sectional study. Demographic information of the participants was collected using well designed self-administered questionnaires. The Montreal Cognitive Assessment (MoCA) test was employed to evaluate the cognitive status of the participants. Semi-quantitative food frequency questionnaire (FFQ) was used to obtain the dietary intake information. Fasting venous blood samples were taken for ApoE genotyping and serum lipid measurements. Significant gender differences in cognition, serum lipid profile and dietary fat-rich foods consumption were observed ( p < 0.05). Cognition of the subjects was found to be associated with ApoE genotypes ( p < 0.05). ApoE rs429358 and rs7412 variants demonstrated a significant effect on cognitive performance in the male subjects; especially within the attention and language cognitive domains as well as the total MoCA score ( p < 0.05), respectively. Serum lipid profile and cognition of Chinese adults are significantly linked with gender and ApoE genetic polymorphism. The ApoE variant rs429358 is found to be notably associated with cognition in aging male Chinese population.
Chen, Tao
2015-07-30
MicroRNAs are a class of small regulatory RNAs that are generated from primary miRNA (pri-miRNA) transcripts with a stem-loop structure. Accuracy of the processing of pri-miRNA into mature miRNA in plants can be enhanced by SERRATE (SE) and HYPONASTIC LEAVES 1 (HYL1). HYL1 activity is regulated by the FIERY2 (FRY2)/RNA polymerase II C-terminal domain phosphatase-like 1 (CPL1). Here, we discover that HIGH OSMOTIC STRESS GENE EXPRESSION 5 (HOS5) and two serine/arginine-rich splicing factors RS40 and RS41, previously shown to be involved in pre-mRNA splicing, affect the biogenesis of a subset of miRNA. These proteins are required for correct miRNA strand selection and the maintenance of miRNA levels. FRY2 dephosphorylates HOS5 whose phosphorylation status affects its subnuclear localization. HOS5 and the RS proteins bind both intronless and intron-containing pri-miRNAs. Importantly, all of these splicing-related factors directly interact with both HYL1 and SE in nuclear splicing speckles. Our results indicate that these splicing factors are directly involved in the biogenesis of a group of miRNA.
Research programme on controlled thermonuclear fusion - Synthesis report 2010
International Nuclear Information System (INIS)
Vaucher, C.; Tran, M. Q.; Villard, L.; Marot, L.
2011-01-01
Since 1978, research on thermonuclear fusion in Switzerland is closely related to the research programme of the European Atomic Energy Community (EURATOM). The Swiss projects tackle aspects of plasma physics and fusion technology. Switzerland participates to the construction and operation of the Joint European Torus (JET). The International Thermonuclear Experimental Reactor (ITER) is being built; the first plasma is expected in 2019. The 'Centre de Recherches en Physique des Plasmas' (CRPP) of the EPFL participates to EURATOM scientific and technological projects in magnetic confinement physics, through an experimental contribution (the Variable Configuration Tokamak, TCV) and theoretical studies. Thanks to the large flexibility of the TCV design and operation modus, plasmas of different shapes can be created and controlled, what is a very useful option to verify numerical simulation results. Besides, the injection of millimetre waves allows directing the injected power according to specific profiles. A configuration of type 'snowflakes' could be created, reducing the power deposition at the edge of the plasma. Theoretical studies on turbulence have improved the plasma stability in the TCV. For the first time in the world, TCV could reach a stable plasma, the plasma current being generated using the so-called 'bootstrap' phenomenon. Besides turbulence, studies were focused on heat and particle transport in tokamaks, on an analysis of the equilibrium and magneto-hydrodynamic stability of tokamaks and stellarators, on the application of radiofrequency waves and on the optimization of new confinement configurations. Experiments in the JET facility confirmed the numerical results of theoretical simulations. The TORPEX facility, which is simpler than TCV, allows high space-temporal resolution measurements for the study of turbulences and plasma threads ('blobs'). At the Paul Scherrer Institute (PSI), research topics include superconductivity and materials. The Fusion
SHBG gene polymorphism (rs1799941 associates with metabolic syndrome in children and adolescents.
Directory of Open Access Journals (Sweden)
Marquitta J White
Full Text Available Metabolic syndrome (MetS is a complex disorder characterized by coexistence of several cardiometabolic (CM factors, i.e. hyperlipidemia, obesity, high blood pressure and insulin resistance. The presence of MetS is strongly associated with increased risk of cardiovascular disease (CVD. The syndrome was originally defined as an adult disorder, but MetS has become increasingly recognized in children and adolescents.Genetic variants influence biological components common to the CM factors that comprise MetS. We investigated single locus associations between six single nucleotide polymorphisms (SNPs, previously shown to modulate lipid or sex hormone binding globulin (SHBG levels, with MetS in a Turkish pediatric cohort (37 cases, 323 controls.Logistic regression analysis revealed a significant association between rs1799941, located in SHBG, and MetS (OR = 3.09, p-value = 0.006. The association with MetS remained after sequential adjustment for each CM factor included in the syndrome definition, indicating that the identified association is not being driven by any single trait. A relationship between rs1799941 and SHBG levels, was also discovered, but it was dependent on MetS status. In control subjects, the A allele of rs1799941 associated with a significant increase in SHBG levels (p = 0.012, while in cases there was no association between rs1799941 and SHBG levels (p = 0.963.The significant association between rs1799941 and MetS in children is not contingent on any single CM trait. Additionally, the presence of MetS may abrogate effect of rs1799941 polymorphism on SHBG levels in children.
International Nuclear Information System (INIS)
Castro, R.G.; Elliott, K.E.; Hollis, K.J.; Watson, R.D.
1999-01-01
Over the past five years, four international parties, which include the European Communities, Japan, the Russian Federation and the United States, have been collaborating on the design and development of the International Thermonuclear Experimental Reactor (ITER), the next generation magnetic fusion energy device. During the ITER Engineering Design Activity (EDA), beryllium plasma spray technology was investigated by Los Alamos National Laboratory as a method for fabricating and repairing and the beryllium first wall surface of the ITER tokamak. Significant progress has been made in developing beryllium plasma spraying technology for this application. Information will be presented on the research performed to improve the thermal properties of plasma sprayed beryllium coatings and a method that was developed for cleaning and preparing the surface of beryllium prior to depositing plasma sprayed beryllium coatings. Results of high heat flux testing of the beryllium coatings using electron beam simulated ITER conditions will also be presented
Design of Bus Protocol Intelligent Initiation System Based On RS485
Directory of Open Access Journals (Sweden)
Li Liming
2017-01-01
Full Text Available In order to design an effective and reliable RS485 bus protocol based on RS485 bus, this paper introduces the structure and transmission mode of the command frame and the response frame, and also introduce four control measures and the communication in order to process quality of this system. The communication protocol is open, tolerant, reliable and fast, and can realize ignition more reliable and accurate in the intelligent initiation system.
Fat phenotype, associated factors and rs9939609 polymorphism of the FTO gene
Directory of Open Access Journals (Sweden)
William Alves Lima
2010-02-01
Full Text Available The purpose of this work was to review the main results of studies that have analysed the relationship between the rs9939609 single nucleotide polymorphism (SNP of the FTO gene and the manifestation of overweight/obesity with its associated co-morbidity, and to discuss the interaction of this polymorphism with the other factors which cause obesity. The search was performed using the MEDLINE, Highwire, Science Direct and SciELO databases, applying the following key words: FTO rs9939609, obesity genetic, gene associated obesity, FTO contributes obesity. Inclusion criteria were: original articles where the search was performed in humans and including the rs9939609. Articles that analysed the FTO gene associated with preinstalled hormonal diseases were excluded. Of the several SNP associated with the FTO gene, rs9939609 has been the most researched (studied. This SNP comprises the A and T alleles, with the A homozygote being most susceptible to the development of overweight/obesity in all age ranges, especially in the caucasian population. In this situation, the control of environmental factors (alimentation and physical activity can prevent the excessive build up of fats. Obesity is related to the development of non-transmissible chronic illnesses. Association of rs9939609 polymorphism with the lipidic profile and glycemia were observed. The practicing of physical exercise and feeding habits seem to be the main contributors in the development of overweight/obesity and its resulting co-morbidity.
Sjöblom, Mikaela; Azimi, Diana
2013-01-01
Syftet med vårt lärdomsprov är att redogöra för familjearbetarnas åsikter om familjearbetet har specifika drag i utförandet av det hos familjer med en försörjare. I teoridelen tas det upp om familjepolitiken i Finland, familjearbete samt om hur en ensamförsörjares livssituation kan se ut. I undersökningen använde vi oss av kvalitativa forskningsintervjuer. Undersökningspersonerna bestod av åtta familjearbetare från fyra olika kommuner. Intervjuerna gjordes både i grupper och som individue...
Li, Yu; Wang, Ke; Xie, Hui; Wang, Yan-Tao; Wang, Dong-Wei; Xu, Chun-Lin; Huang, Xin; Wang, De-Sen
2015-01-01
Radopholus similis is a migratory plant-parasitic nematode that causes severe damage to many agricultural and horticultural crops. Calreticulin (CRT) is a Ca2+-binding multifunctional protein that plays key roles in the parasitism, immune evasion, reproduction and pathogenesis of many animal parasites and plant nematodes. Therefore, CRT is a promising target for controlling R. similis. In this study, we obtained the full-length sequence of the CRT gene from R. similis (Rs-crt), which is 1,527-bp long and includes a 1,206-bp ORF that encodes 401 amino acids. Rs-CRT and Mi-CRT from Meloidogyne incognita showed the highest similarity and were grouped on the same branch of the phylogenetic tree. Rs-crt is a multi-copy gene that is expressed in the oesophageal glands and gonads of females, the gonads of males, the intestines of juveniles and the eggs of R. similis. The highest Rs-crt expression was detected in females, followed by juveniles, eggs and males. The reproductive capability and pathogenicity of R. similis were significantly reduced after treatment with Rs-crt dsRNA for 36 h. Using plant-mediated RNAi, we confirmed that Rs-crt expression was significantly inhibited in the nematodes, and resistance to R. similis was significantly improved in transgenic tomato plants. Plant-mediated RNAi-induced silencing of Rs-crt could be effectively transmitted to the F2 generation of R. similis; however, the silencing effect of Rs-crt induced by in vitro RNAi was no longer detectable in F1 and F2 nematodes. Thus, Rs-crt is essential for the reproduction and pathogenicity of R. similis.
Directory of Open Access Journals (Sweden)
Yu Li
Full Text Available Radopholus similis is a migratory plant-parasitic nematode that causes severe damage to many agricultural and horticultural crops. Calreticulin (CRT is a Ca2+-binding multifunctional protein that plays key roles in the parasitism, immune evasion, reproduction and pathogenesis of many animal parasites and plant nematodes. Therefore, CRT is a promising target for controlling R. similis. In this study, we obtained the full-length sequence of the CRT gene from R. similis (Rs-crt, which is 1,527-bp long and includes a 1,206-bp ORF that encodes 401 amino acids. Rs-CRT and Mi-CRT from Meloidogyne incognita showed the highest similarity and were grouped on the same branch of the phylogenetic tree. Rs-crt is a multi-copy gene that is expressed in the oesophageal glands and gonads of females, the gonads of males, the intestines of juveniles and the eggs of R. similis. The highest Rs-crt expression was detected in females, followed by juveniles, eggs and males. The reproductive capability and pathogenicity of R. similis were significantly reduced after treatment with Rs-crt dsRNA for 36 h. Using plant-mediated RNAi, we confirmed that Rs-crt expression was significantly inhibited in the nematodes, and resistance to R. similis was significantly improved in transgenic tomato plants. Plant-mediated RNAi-induced silencing of Rs-crt could be effectively transmitted to the F2 generation of R. similis; however, the silencing effect of Rs-crt induced by in vitro RNAi was no longer detectable in F1 and F2 nematodes. Thus, Rs-crt is essential for the reproduction and pathogenicity of R. similis.
DeAnnIso: a tool for online detection and annotation of isomiRs from small RNA sequencing data.
Zhang, Yuanwei; Zang, Qiguang; Zhang, Huan; Ban, Rongjun; Yang, Yifan; Iqbal, Furhan; Li, Ao; Shi, Qinghua
2016-07-08
Small RNA (sRNA) Sequencing technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent variations from their canonical sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). However, integrated tool to precisely detect and systematically annotate isomiRs from sRNA sequencing data is still in great demand. Here, we present an online tool, DeAnnIso (Detection and Annotation of IsomiRs from sRNA sequencing data). DeAnnIso can detect all the isomiRs in an uploaded sample, and can extract the differentially expressing isomiRs from paired or multiple samples. Once the isomiRs detection is accomplished, detailed annotation information, including isomiRs expression, isomiRs classification, SNPs in miRNAs and tissue specific isomiR expression are provided to users. Furthermore, DeAnnIso provides a comprehensive module of target analysis and enrichment analysis for the selected isomiRs. Taken together, DeAnnIso is convenient for users to screen for isomiRs of their interest and useful for further functional studies. The server is implemented in PHP + Perl + R and available to all users for free at: http://mcg.ustc.edu.cn/bsc/deanniso/ and http://mcg2.ustc.edu.cn/bsc/deanniso/. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.
8q24 rs6983267G variant is associated with increased thyroid cancer risk
Sahasrabudhe, Ruta; Estrada, Ana; Lott, Paul; Martin, Lynn; Echeverry, Guadalupe Polanco; Velez, Alejandro; Neta, Gila; Takahasi, Meiko; Saenko, Vladimir; Mitsutake, Norisato; Jaeguer, Emma; Duque, Carlos Simon; Rios, Alejandro; Bohorquez, Mabel; Prieto, Rodrigo; Criollo, Angel; Echeverry, Magdalena; Tomlinson, Ian; Carvajal Carmona, Luis G.
2015-01-01
The G allele of the rs6983267 single nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in thyroid cancer susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3,067 cases and 8,575 controls. We detected significant associations between rs6983267G and thyroid cancer in the British Isles (Odds Ratio, OR= 1.19, 95% confidence interval, CI: 1.11–1.27, P= 4.03 × 10−7), Japan (OR= 1.20, 95% CI: 1.03–1.41, P= 0.022) and a borderline significant association of similar effect direction and size in Colombia (OR= 1.19, 95% CI: 0.99–1.44, P= 0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5,484 cases and 12,594 controls, confirmed the association between rs6983267G and thyroid cancer (P= 1.23 × 10−7, OR= 1.13, 95% CI: 1.07–1.18). Our results therefore support the notion that rs6983267G is a bona fide thyroid cancer risk variant that increases the risk of disease by ~13%. PMID:26290501
Blending the most fundamental Remote-Sensing principles (RS ...
African Journals Online (AJOL)
Blending the most fundamental Remote-Sensing principles (RS) with the most functional spatial knowledge (GIS) with the objective of the determination of the accident-prone palms and points (case study: Tehran-Hamadan Highway on Saveh Superhighway)
International Nuclear Information System (INIS)
Ajtkhozhin, Eh.S.; Maksimkin, O.P.
2007-01-01
Review of scientific literature for last 5 years in which results on study of radiation effect on ferrite-martensite steels - construction materials of fast reactors and most probable candidates for first wall and blanket of the thermonuclear facilities ITER and Demo - are presented. Alongside with this a prior experimental data on study of microstructure changing and physical- mechanical properties of ferrite-martensite steel EhP-450 - the material of hexahedral case of spent assembly of BN-350 fast reactor- are cited. Principal attention was paid to considering of radiation effects of structural components content changing and ferrite-martensite steel swelling irradiated at comparatively low values of radiation damage climb rate
IL-1B rs16944 polymorphism is related to septic shock and death.
Jiménez-Sousa, María Ángeles; Medrano, Luz M; Liu, Pilar; Almansa, Raquel; Fernández-Rodríguez, Amanda; Gómez-Sánchez, Esther; Rico, Lucía; Heredia-Rodríguez, María; Gómez-Pesquera, Estefanía; Tamayo, Eduardo; Resino, Salvador
2017-01-01
IL-1β is a primary mediator of systemic inflammatory response syndrome (SIRS) and it may lead to shock septic. Our aim was to analyse whether IL-1B rs16944 polymorphism is associated with the onset of septic shock and death after major surgery. We performed a case-control study on 467 patients who underwent major cardiac or abdominal surgery. Of them, 205 patients developed septic shock (cases, SS group) and 262 patients developed SIRS (controls, SIRS group). The primary outcome variables were the development of septic shock and death within 90 days after diagnosis of septic shock. The IL-1B rs16944 polymorphism was genotyped by Sequenom's MassARRAY platform. The association analysis was performed under a recessive genetic model (AA vs. GG/GC). The frequency of septic shock was higher in patients with IL-1B rs16944 AA genotype than in patients with IL-1B rs16944 GG/AG genotype when all patients were taken into account (63·6% vs. 41·8%; P = 0·006), cardiac surgery (52·2% vs. 33·3%; P = 0·072) and abdominal surgery (76·2% vs. 50·2%; P = 0·023). However, the IL-1B rs16944 AA genotype was only associated with higher likelihood of septic shock in the analysis of all population [adjusted odds ratio (aOR) = 2·26 (95%CI = 1·03; 4·97; P = 0·042], but not when it was stratified by cardiac surgery (P = 0·175) or abdominal surgery (P = 0·467). Similarly, IL-1B rs16944 AA genotype was also associated with higher likelihood of septic shock-related death in all population [aOR = 2·67 (95%CI = 1·07; 4·97); P = 0·035]. IL-1B rs16944 AA genotype seems to be related to the onset of septic shock and death in patients who underwent major surgery. © 2016 Stichting European Society for Clinical Investigation Journal Foundation.
P-bRS: A Physarum-Based Routing Scheme for Wireless Sensor Networks
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Mingchuan Zhang
2014-01-01
Full Text Available Routing in wireless sensor networks (WSNs is an extremely challenging issue due to the features of WSNs. Inspired by the large and single-celled amoeboid organism, slime mold Physarum polycephalum, we establish a novel selecting next hop model (SNH. Based on this model, we present a novel Physarum-based routing scheme (P-bRS for WSNs to balance routing efficiency and energy equilibrium. In P-bRS, a sensor node can choose the proper next hop by using SNH which comprehensively considers the distance, energy residue, and location of the next hop. The simulation results show how P-bRS can achieve the effective trade-off between routing efficiency and energy equilibrium compared to two famous algorithms.
Directory of Open Access Journals (Sweden)
Ortega-Azorín Carolina
2012-11-01
Full Text Available Abstract Background Although the Fat Mass and Obesity (FTO and Melanocortin-4 Receptor (MC4R genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI. However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet. Methods Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes cases and 3,622 non-diabetic subjects with no differences in BMI. Diet was assessed by validated questionnaires. FTO-rs9939609 and MC4R-rs17782313 were determined. An aggregate genetic score was calculated to test additive effects. Gene-diet interactions were analyzed. Results Neither of the polymorphisms was associated with type 2 diabetes in the whole population. However, we found consistent gene-diet interactions with adherence to the MedDiet both for the FTO-rs9939609 (P-interaction=0.039, the MC4R-rs17782313 (P-interaction=0.009 and for their aggregate score (P-interaction=0.006. When adherence to the MedDiet was low, carriers of the variant alleles had higher type 2 diabetes risk (OR=1.21, 95%CI: 1.03-1.40; P=0.019 for FTO-rs9939609 and OR=1.17, 95%CI:1.01-1.36; P=0.035 for MC4R-rs17782313 than wild-type subjects. However, when adherence to the MedDiet was high, these associations disappeared (OR=0.97, 95%CI: 0.85-1.16; P=0.673 for FTO-rs9939609 and OR=0.89, 95%CI:0.78-1.02; P=0.097 for MC4R-rs17782313. These gene-diet interactions remained significant even after adjustment for BMI. As MedDiet is rich in folate, we also specifically examined folate intake and detected statistically significant interaction effects on fasting plasma glucose
The miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency.
Pan, Hong; Chen, Beili; Wang, Jing; Wang, Xi; Hu, Ping; Wu, Shinan; Liu, Yunyun; Xu, Zuying; Zhang, Wei; Wang, Binbin; Cao, Yunxia
2016-09-01
To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis. From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry. Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI. Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.
Propagation of ELF Radiation from RS-LC System and Red Sprites in Earth-Ionosphere Waveguide
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M. K. Paras
2012-10-01
Full Text Available In this paper, two different mechanisms return stroke-lateral corona (RS-LC system and red sprites which excite Earth-ionosphere waveguide have been discussed. The electric and magnetic fields from RS-LC system and red spites in the Earth-ionosphere waveguide have been calculated. It has been found that red sprites contribute to the Schumann resonances (SR greatly as compared to the RS-LC system.
Wang, Shiyan; Tian, Linwei; Zeng, Zhirong; Zhang, Mingdong; Wu, Kaichun; Chen, Minhu; Fan, Daiming; Hu, Pinjin; Sung, Joseph J Y; Yu, Jun
2010-02-05
Nuclear factor of kappa B inhibitor alpha (I kappaB alpha) protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C genotype in the promoter region of I kappaB alpha to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients. A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in I kappaB alpha were analyzed by TaqMan SNP genotyping assay. Both rs2233408 T homozygote (TT) and T heterozygotes (TC and TT) had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, P = 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, P = 0.037), compared with rs2233408 C homozygote (CC). rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, P = 0.014), but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40) (OR = 0.674, 95% CI = 0.484-0.939, P = 0.02). rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, P = 0.006), but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients. I kappaB alpha rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.
Directory of Open Access Journals (Sweden)
Sung Joseph JY
2010-02-01
Full Text Available Abstract Background Nuclear factor of kappa B inhibitor alpha (IκBα protein is implicated in regulating a variety of cellular process from inflammation to tumorigenesis. The objective of this study was to investigate the susceptibility of rs2233408 T/C genotype in the promoter region of IκBα to gastric cancer and the association of this polymorphism with clinicopathologic variables in gastric cancer patients. Methods A population-based case-control study was conducted between 1999 and 2006 in Guangdong Province, China. A total of 564 gastric cancer patients and 566 healthy controls were enrolled in this study. rs2233408 genotypes in IκBα were analyzed by TaqMan SNP genotyping assay. Results Both rs2233408 T homozygote (TT and T heterozygotes (TC and TT had significantly reduced gastric cancer risk (TT: OR = 0.250, 95% CI = 0.069-0.909, P = 0.035; TC and TT: OR = 0.721, 95% CI = 0.530-0.981, P = 0.037, compared with rs2233408 C homozygote (CC. rs2233408 T heterozygotes were significantly associated with reduced risk of intestinal-type gastric cancer with ORs of 0.648 (95% CI = 0.459-0.916, P = 0.014, but not with the diffuse or mix type of gastric cancer. The association between rs2233408 T heterozygotes and gastric cancer appeared more apparent in the older patients (age>40 (OR = 0.674, 95% CI = 0.484-0.939, P = 0.02. rs2233408 T heterozygotes was associated with non-cardiac gastric cancer (OR = 0.594, 95% CI = 0.411-0.859, P = 0.006, but not with cardiac gastric cancer. However, rs2233408 polymorphism was not associated with the prognosis of gastric cancer patients. Conclusions IκBα rs2233408 T heterozygotes were associated with reduced risk of gastric cancer, especially for the development of certain subtypes of gastric cancer in Chinese population.
The CHRNA3 rs578776 variant is associated with an intrinsic reward sensitivity deficit in smokers
Directory of Open Access Journals (Sweden)
Jason D. Robinson
2013-09-01
Full Text Available A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR and dopamine (DA expression were related to an intrinsic reward sensitivity (IRS deficit we previously identified among a subgroup of smokers using event-related potentials (ERPs. We examined genetic polymorphisms within the CHRNA5-A3-B4 gene cluster (CHRNA3 rs578776, CHRNA5 rs16969968, LOC123688 rs8034191, and CHRNA3 rs1051730, the ANKK1 gene (rs1800497, and the D2 receptor gene (DRD2 rs1079597, DRD2 rs1799732 from 104 smokers of European ancestry in a smoking cessation trial. Prior to treatment, we recorded ERPs evoked by emotional (both pleasant and unpleasant, neutral, and cigarette-related pictures. Smokers were assigned to two groups (IRS+/IRS- based on the amplitude of the late positive potential (LPP component to the pictures, a neural marker of motivational salience. Smokers (n = 42 with blunted brain responses to intrinsically rewarding (pleasant pictures and enhanced responses to cigarette pictures were assigned to the IRS- group, while smokers (n = 62 with the opposite pattern of LPP responding were assigned to the IRS+ group. Carriers of the protective minor T allele (T/T, C/T of the CHRNA3 rs578776 were less likely to be members of the IRS- group than those homozygous for the at-risk C allele (C/C. The CHRNA3 rs578776 polymorphism did not differ on questionnaires of nicotine dependence, depressed mood, or trait affective disposition and did not predict abstinence at 6 months after the quit date. These results suggest that polymorphisms of genes influencing nAChR expression are related to an endophenotype of reward sensitivity in smokers.
The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers.
Robinson, Jason D; Versace, Francesco; Lam, Cho Y; Minnix, Jennifer A; Engelmann, Jeffrey M; Cui, Yong; Karam-Hage, Maher; Shete, Sanjay S; Tomlinson, Gail E; Chen, Tina T-L; Wetter, David W; Green, Charles E; Cinciripini, Paul M
2013-01-01
A compromised brain reward system has been postulated as a key feature of drug dependence. We examined whether several polymorphisms of genes found to regulate nicotinic acetylcholine receptor (nAChR) and dopamine expression were related to an intrinsic reward sensitivity (IRS) deficit we previously identified among a subgroup of smokers using event-related potentials (ERPs). We examined genetic polymorphisms within the CHRNA5-A3-B4 gene cluster (CHRNA3 rs578776, CHRNA5 rs16969968, LOC123688 rs8034191, and CHRNA3 rs1051730), the ANKK1 gene (rs1800497), and the D2 dopamine receptor gene (DRD2 rs1079597, DRD2 rs1799732) from 104 smokers of European ancestry in a smoking cessation trial. Prior to treatment, we recorded ERPs evoked by emotional (both pleasant and unpleasant), neutral, and cigarette-related pictures. Smokers were assigned to two groups (IRS+/IRS-) based on the amplitude of the late positive potential (LPP) component to the pictures, a neural marker of motivational salience. Smokers (n = 42) with blunted brain responses to intrinsically rewarding (pleasant) pictures and enhanced responses to cigarette pictures were assigned to the IRS- group, while smokers (n = 62) with the opposite pattern of LPP responding were assigned to the IRS+ group. Carriers of the protective minor T allele (T/T, C/T) of the CHRNA3 rs578776 were less likely to be members of the IRS- group than those homozygous for the at-risk C allele (C/C). The CHRNA3 rs578776 polymorphism did not differ on questionnaires of nicotine dependence, depressed mood, or trait affective disposition and did not predict abstinence at 6 months after the quit date. These results suggest that polymorphisms of genes influencing nAChR expression are related to an endophenotype of reward sensitivity in smokers.
Recommendations for a cryogenic system for ITER [International Thermonuclear Experimental Reactor
International Nuclear Information System (INIS)
Slack, D.S.
1989-01-01
The International Thermonuclear Experimental Reactor (ITER) is a new tokamak design project with joint participation from Japan, the European Community, the Soviet Union, and the United States. ITER will be a large machine requiring up to 100 kW of refrigeration at 4.5 K to cool its superconducting magnets. Unlike earlier fusion experiments, the ITER cryogenic system must handle pulse loads constituting a large percentage of the total load. These come from neutron heating during a fusion burn and from ac losses during ramping of current in the PF (poloidal field) coils. This paper presents a conceptual design for a cryogenic system that meets ITER requirements. It describes a system with the following features: Only time-proven components are used. The system obtains a high efficiency without use of cold pumps or other developmental components. High reliability is achieved by paralleling compressors and expanders and by using adequate isolation valving. The problem of load fluctuations is solved by a simple load-leveling device. The cryogenic system can be housed in a separate building located at a considerable distance from the ITER core, if desired. The paper also summarizes physical plant size, cost estimates, and means of handling vented helium during magnet quench. 4 refs., 4 figs., 3 tabs
Radiological dose rate calculations for the International Thermonuclear Experimental Reactor (ITER)
International Nuclear Information System (INIS)
Khater, H.Y.; Santoro, R.T.
1996-01-01
Two-dimensional biological dose rates were calculated at different locations outside the International Thermonuclear Experimental Reactor (ITER) design. An 18 degree sector of the reactor was modeled in r-θ geometry. The calculations were performed for three different pulsing scenarios. This included a single pulse of 1000 s duration, 10 pulses of 1000 s duration with a 50% duty factor, and 9470 pulses of 1000 s duration with a 50% duty factor for a total fluence of 0.3 MW.a/m 2 . The dose rates were calculated as a function of toroidal angle at locations in the space between the toroidal field (TF) coils and cryostat, and in the space between the cryostat and the biological shield. The two-dimensional results clearly showed the toroidal effect, which is dominated by contribution from the activation of the cryostat and the biological shield. After one pulse, full access to the machine is possible within a few hours following shutdown. After 10 pulses, full access is also possible within the first day following shutdown. At the end of the Basic Performance Phase (BPP), full access is possible at any of the locations considered after one week following shutdown. 5 refs., 5 figs., 2 tabs
Plasma-materials interaction issues for the International Thermonuclear Experimental Reactor (ITER)
International Nuclear Information System (INIS)
Cohen, S.A.; Werley, K.A.
1992-02-01
Analysis of proposed operating scenarios for the International Thermonuclear Experimental Reactor has yielded predictions for the power and particle fluxes onto the material surfaces facing the plasma. The particles, mostly deuterium, tritium, and helium ions, would have energies in the range of 50--2000 eV and fluxes up to 5 x 10 23 /m 2 s. Lower fluxes of multi-MeV electrons and alpha particles may also strike the plasma-facing surfaces, primarily during transient events. The peak power fluxes onto the plasma-facing surfaces during normal operation are expected to be 5--100 MW/m 2 , but much higher during transient events. At the extreme conditions expected for steady-state operation, commonly used heat-removal structures are unable to withstand either the high sputter erosion rates or power loads. To reduce the time-averaged power flux, active control of the plasma position is specified to sweep the plasma heat load across larger areas of plasma-facing components. However, the cyclic heat load creates fatigue lifetime problems. Solutions to these lifetime and reliability problems by (1) changes in machine design and operation, (2) redeposition mechanisms, and (3) changes in materials, will be discussed. A proposed accelerated-life test facility for prototype divertor plate development is described
Directory of Open Access Journals (Sweden)
Jie Zhen
2017-08-01
Full Text Available ApoE gene polymorphism has been reportedly associated with serum lipids and cognition. However, very few studies have explored the combined effects of ApoE gene polymorphism and gender on serum lipid profile with subsequent impacts on cognition in Chinese population. A total of 1,000 Chinese community dwellers aged 55 years and above were recruited in this cross-sectional study. Demographic information of the participants was collected using well designed self-administered questionnaires. The Montreal Cognitive Assessment (MoCA test was employed to evaluate the cognitive status of the participants. Semi-quantitative food frequency questionnaire (FFQ was used to obtain the dietary intake information. Fasting venous blood samples were taken for ApoE genotyping and serum lipid measurements. Significant gender differences in cognition, serum lipid profile and dietary fat-rich foods consumption were observed (p < 0.05. Cognition of the subjects was found to be associated with ApoE genotypes (p < 0.05. ApoE rs429358 and rs7412 variants demonstrated a significant effect on cognitive performance in the male subjects; especially within the attention and language cognitive domains as well as the total MoCA score (p < 0.05, respectively. Serum lipid profile and cognition of Chinese adults are significantly linked with gender and ApoE genetic polymorphism. The ApoE variant rs429358 is found to be notably associated with cognition in aging male Chinese population.
International Nuclear Information System (INIS)
Laval, Guy; Blanzat, Bernard; Aspect, Alain; Aymar, Robert; Bielak, Bogdan; Decroisette, Michel; Martin, Georges; Andre, Michel; Schirmann, Daniel; Garbet, Xavier; Jacquinot, Jean; Laviron, Clement; Migus, Arnold; Moreau, Rene; Pironneau, Olivier; Quere, Yves; Vallee, Alain; Dercourt, Jean; Bayer, Charles; Juraszek, Denis; Deutsch, Claude; Le Garrec, Bruno; Hennequin, Pascale; Peysson, Yves; Rax, Jean-Marcel; Pesme, Denis; Bauche, Jacques; Monier-Garbet, Pascale; Stamm, Roland; Zerah, Gilles; Ghendrih, Philippe; Layet, Roland; Grosman, Andre; Alamo, Ana; Giancarli, Luciano; Poitevin, Yves; Rigal, Emmanuel; Chieze, Jean-Pierre
2007-01-01
This work has been commissioned by the French ministry of Education, Sciences and Research, its aim is to provide a reliable account of the state of development of thermonuclear fusion. This report makes a point on the scientific knowledge accumulated on the topic and highlights the research programs that are necessary to overcome the technological difficulties and draws the necessary steps before an industrial application to electricity production. This report is divided into 10 chapters: 1) tokamak technology and ITER, 2) inertial fusion, 3) magnetized hot plasmas, 4) laser-plasma interaction and peta-watt lasers, 5) atomic physics and fusion, 6) computer simulation, 7) plasma-wall interaction, 8) materials for fusion reactors, 9) safety analysis, and 10) inertial fusion and astrophysics. This report has been written by a large panel of experts gathered by the French Academy of Sciences. The comments on the issue by the 3 French organizations: Cea, Cnrs and SFP (French Society of Physics) follow the last chapter
Heating and cooling device for use in the vacuum container of a thermonuclear device
International Nuclear Information System (INIS)
Morita, Hiroaki; Onozuka, Masanori; Fukui, Hiroshi.
1986-01-01
Purpose: To prevent the generation of great temperature difference within a hollow doughnuts-shaped space of the torus vacuum container of a tokamak type thermonuclear reactor, as well as effectively eliminate the local injection of heat to the vacuum container. Constitution: A hollow doughnuts-like space is formed between the inner wall and the double outer wall of a vacuum container main body, which is divided into a plurality of regions by partition plates extended in the toroidal direction. An input/output header is disposed in adjacent with each of the partition plates for inputting/outputting heat medium. Further, heat medium inlet/outlets are disposed to define two flow channels on every one-half circumference. This enables to reduce the temperature difference of the heat medium between the inlet and the outlet by the shortening of the flow channel length and heating or cooling can be performed without causing unevenness in the temperature distribution of the vacuum container. (Horiuchi, T.)
Thermonuclear process and accretion onto neutron star envelopes: x-ray burst and transient sources
International Nuclear Information System (INIS)
Starrfield, S.; Kenyon, S.; Sparks, W.M.; Truran, J.W.; Theoretical Division, Los Alamos National Laboratory)
1982-01-01
We have used a Lagrangian, fully implicit, one-dimensional, hydrodynamic computer code to investigate the evolution of thermonuclear runaways in the thick, accreted, hydrogen-rich envelopes of 1.0 M/sub sun/ neutron stars with radii of 10 km and 20 km. Our simulations produce outbursts which range in time scale from about 2000 seconds to longer than 1 day. Peak effective temperature was 3.3 x 10 7 K (kTapprox.2.91 keV), and peak luminosity was 2 x 10 5 L/sub sun/ for the 10 km study. The 20 km neutron star produced a peak effective temperature and luminosity of 5.3 x 10 6 K and 5.9 x 10 2 L/sub sun/, respectively. We also investigated the effects of changes in the rates of the 14 O(α,p) and 15 O(α,ν) reactions on the evolution. Hydrodynamic expansion on the 10 km neutron star produced a precursor lasting about 10 - 6 seconds
International Nuclear Information System (INIS)
1987-04-01
The Summit Members' Working Group on Controlled Thermonuclear Fusion [Fusion Working Group (FWG)] was established in 1983 in response to the Declaration of the Heads of State and Government at the Versailles Economic Summit meeting of 1982, and in response to the subsequent report of the Working Group in Technology, Growth and Employment (TGE) as endorsed at the Williamsburg Summit meeting, 1983. This document contains the complete written record of each of the three FWG meetings which include the minutes, lists of attendees, agendas, statements, and summary conclusions as well as the full reports of the Technical Working Party. In addition, there is a pertinent exchange of correspondence between FWG members on the role of the Technical Working Party and a requested background paper on the modalities associated with a possible future ETR project
Mazhari, Shahrzad; Ghafaree-Nejad, Ali R; Soleymani-Zade, Somayeh; Keefe, Richard S E
2017-06-01
The Schizophrenia Cognition Rating Scale (SCoRS) is an interview-based assessment of cognition that involves interviews with patients and informants. The SCoRS has shown good reliability, validity, and sensitivity to cognitive impairment in schizophrenia, with the advantage of brief administration and scoring time. The present study aimed to test the concurrent validity of the Persian version of the SCoRS. A group of 35 patients with schizophrenia and a group of 35 healthy controls received the Persian-SCoRS in the first session, and a standardized performance-based cognitive battery, the Brief Assessment of Cognition in Schizophrenia (BACS), in the second session.Our results indicated that the Persian version of the SCoRS was sensitive to cognitive impairment in the patients. The Persian SCoRS global rating was significantly associated with the composite score generated from the Persian version of the BACS and predicted functional outcomes as measured by Global Assessment of Functioning (GAF) and World Health Organization Quality of Life (WHO QOL). A Persian version of the SCoRS, an interview based measure of cognition that included informants, is related to cognitive performance and global functioning. Copyright © 2017 Elsevier B.V. All rights reserved.
Kim, Johanna I; Kim, Jae-Won; Park, Jong-Eun; Park, Subin; Hong, Soon-Beom; Han, Doug Hyun; Cheong, Jae Hoon; Choi, Jae-Won; Lee, Sumin; Kim, Bung-Nyun
2017-08-01
We investigated the possible association between two NMDA subunit gene polymorphisms (GRIN2B rs2284411 and GRIN2A rs2229193) and treatment response to methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD). A total of 75 ADHD patients aged 6-17 years underwent 6 months of MPH administration. Treatment response was defined by changes in scores of the ADHD-IV Rating Scale (ADHD-RS), clinician-rated Clinical Global Impression-Improvement (CGI-I), and Continuous Performance Test (CPT). The association of the GRIN2B and GRIN2A polymorphisms with treatment response was analyzed using logistic regression analyses. The GRIN2B rs2284411 C/C genotype showed significantly better treatment response as assessed by ADHD-RS inattention ( p=0.009) and CGI-I scores ( p=0.009), and there was a nominally significant association in regard to ADHD-RS hyperactivity-impulsivity ( p=0.028) and total ( p=0.023) scores, after adjusting for age, sex, IQ, baseline Clinical Global Impression-Severity (CGI-S) score, baseline ADHD-RS total score, and final MPH dose. The GRIN2B C/C genotype also showed greater improvement at the CPT response time variability ( pADHD.
Wang, Li; Widatalla, Sarrah E; Whalen, Diva S; Ochieng, Josiah; Sakwe, Amos M
2017-08-02
Breast cancer (BC) patients with late-stage and/or rapidly growing tumors are prone to develop high serum calcium levels which have been shown to be associated with larger and aggressive breast tumors in post and premenopausal women respectively. Given the pivotal role of the calcium sensing receptor (CaSR) in calcium homeostasis, we evaluated whether polymorphisms of the CASR gene at rs1801725 and rs1801726 SNPs in exon 7, are associated with circulating calcium levels in African American and Caucasian control subjects and BC cases. In this retrospective case-control study, we assessed the mean circulating calcium levels, the distribution of two inactivating CaSR SNPs at rs1801725 and rs1801726 in 199 cases and 384 age-matched controls, and used multivariable regression analysis to determine whether these SNPs are associated with circulating calcium in control subjects and BC cases. We found that the mean circulating calcium levels in African American subjects were higher than those in Caucasian subjects (p calcium levels were higher in BC cases compared to control subjects (p calcium levels in BC patients were independent of race. We also show that in BC cases and control subjects, the major alleles at rs1801725 (G/T, A986S) and at rs1801726 (C/G, Q1011E) were common among Caucasians and African Americans respectively. Compared to the wild type alleles, polymorphisms at the rs1801725 SNP were associated with higher calcium levels (p = 0.006) while those at rs1801726 were not. Using multivariable linear mixed-effects models and adjusting for age and race, we show that circulating calcium levels in BC cases were associated with tumor grade (p = 0.009), clinical stage (p = 0.003) and more importantly, with inactivating mutations of the CASR at the rs1801725 SNP (p = 0.038). These data suggest that decreased sensitivity of the CaSR to calcium due to inactivating polymorphisms at rs1801725, may predispose up to 20% of BC cases to high circulating calcium
ChemiRs: a web application for microRNAs and chemicals.
Su, Emily Chia-Yu; Chen, Yu-Sing; Tien, Yun-Cheng; Liu, Jeff; Ho, Bing-Ching; Yu, Sung-Liang; Singh, Sher
2016-04-18
MicroRNAs (miRNAs) are about 22 nucleotides, non-coding RNAs that affect various cellular functions, and play a regulatory role in different organisms including human. Until now, more than 2500 mature miRNAs in human have been discovered and registered, but still lack of information or algorithms to reveal the relations among miRNAs, environmental chemicals and human health. Chemicals in environment affect our health and daily life, and some of them can lead to diseases by inferring biological pathways. We develop a creditable online web server, ChemiRs, for predicting interactions and relations among miRNAs, chemicals and pathways. The database not only compares gene lists affected by chemicals and miRNAs, but also incorporates curated pathways to identify possible interactions. Here, we manually retrieved associations of miRNAs and chemicals from biomedical literature. We developed an online system, ChemiRs, which contains miRNAs, diseases, Medical Subject Heading (MeSH) terms, chemicals, genes, pathways and PubMed IDs. We connected each miRNA to miRBase, and every current gene symbol to HUGO Gene Nomenclature Committee (HGNC) for genome annotation. Human pathway information is also provided from KEGG and REACTOME databases. Information about Gene Ontology (GO) is queried from GO Online SQL Environment (GOOSE). With a user-friendly interface, the web application is easy to use. Multiple query results can be easily integrated and exported as report documents in PDF format. Association analysis of miRNAs and chemicals can help us understand the pathogenesis of chemical components. ChemiRs is freely available for public use at http://omics.biol.ntnu.edu.tw/ChemiRs .
Effects of VRK2 (rs2312147 on white matter connectivity in patients with schizophrenia.
Directory of Open Access Journals (Sweden)
Hoyoung Sohn
Full Text Available Recent genome-wide association studies of schizophrenia reported a novel risk variant, rs2312147 at vaccinia-related kinase 2 gene (VRK2, in multiple Asian and European samples. However, its effect on the brain structure in schizophrenia is little known. We analyzed the brain structure of 36 schizophrenia patients and 18 healthy subjects with regard to rs2312147 genotype groups. Brain magnetic resonance scans for gray matter (GM and white matter (WM analysis, and genotype analysis for VRK2 rs2312147, were conducted. The Positive and Negative Syndrome Scale and the Digit Symbol Test were assessed for schizophrenia patients. There was no significant difference in either GM volume or WM connectivity with regard to rs2312147 genotype in healthy subjects. In contrast, we found significant differences in the WM connectivity between rs2312147 CC and CT/TT genotype groups of schizophrenia patients. The related brain areas included the splenium of corpus callosum, the left occipital lobe WM, the internal capsule (left anterior limb and right retrolenticular part, the bilateral temporal lobe WM, the left fornix/stria terminalis, the left cingulate gyrus WM, and the left parietal lobe WM. Voxelwise correlation analysis revealed that the Digit Symbol Test scores (age corrected correlated with the fractional anisotropy in WM tracts that previously showed significant group differences between the CT/TT and CC genotypes in the rs2312147 CT/TT genotype group, while no significant correlation was found in the CC genotype group. Our data may provide evidence for the effect of VRK2 on WM connectivity in patients with schizophrenia.
International Nuclear Information System (INIS)
Lasalle, J.
1975-06-01
A new method which greatly simplifies the number of measurements necessary for obtaining the temperature in thermonuclear plasmas, using the relativistic effects of Thomson scattering is presented. A few orders of magnitude are computed for probing the feasibility of such temperature measurements. The data used correspond to magnitudes relating to T.F.R. The characteristics of a filter equipped spectrometer are then defined in view of a double function: separation of the lambda>lambda laser and lambda [fr
LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population.
Zhang, Zhuorong; Chang, Yitian; Jia, Wei; Zhang, Jiao; Zhang, Ruizhong; Zhu, Jinhong; Yang, Tianyou; Xia, Huimin; Zou, Yan; He, Jing
2018-02-28
Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C>T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C>T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C>T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06-3.06, P =0.029; TT/CT compared with CC: adjusted OR =1.31, 95% CI =1.02-1.67, P =0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06-1.58, P =0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06-2.14, P =0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12-2.30, P =0.011). In conclusion, we verified that the LINC00673 rs11655237 C>T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings. © 2018 The Author(s).
The 8q24 rs6983267G variant is associated with increased thyroid cancer risk.
Sahasrabudhe, Ruta; Estrada, Ana; Lott, Paul; Martin, Lynn; Polanco Echeverry, Guadalupe; Velez, Alejandro; Neta, Gila; Takahasi, Meiko; Saenko, Vladimir; Mitsutake, Norisato; Jaeguer, Emma; Duque, Carlos Simon; Rios, Alejandro; Bohorquez, Mabel; Prieto, Rodrigo; Criollo, Angel; Echeverry, Magdalena; Tomlinson, Ian; Carmona, Luis G Carvajal
2015-10-01
The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11-1.27, P=4.03×10(-7)), Japan (OR=1.20, 95% CI: 1.03-1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99-1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10(-7), OR=1.13, 95% CI: 1.08-1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%. © 2015 Society for Endocrinology.
Directory of Open Access Journals (Sweden)
Alexander Kuryatov
Full Text Available Functional α7 nicotinic acetylcholine receptors (AChRs do not assemble efficiently in cells transfected with α7 subunits unless the cells are also transfected with the chaperone protein RIC-3. Despite the presence of RIC-3, large amounts of these subunits remain improperly assembled. Thus, additional chaperone proteins are probably required for efficient assembly of α7 AChRs. Cholinergic ligands can act as pharmacological chaperones to promote assembly of mature AChRs and upregulate the amount of functional AChRs. In addition, we have found that the chemical chaperones 4-phenylbutyric acid (PBA and valproic acid (VPA greatly increase the amount of functional α7 AChRs produced in a cell line expressing both α7 and RIC-3. Increased α7 AChR expression allows assay of drug action using a membrane potential-sensitive fluorescent indicator. Both PBA and VPA also increase α7 expression in the SH-SY5Y neuroblastoma cell line that endogenously expresses α7 AChRs. VPA increases expression of endogenous α7 AChRs in hippocampal neurons but PBA does not. RIC-3 is insufficient for optimal assembly of α7 AChRs, but provides assay conditions for detecting additional chaperones. Chemical chaperones are a useful pragmatic approach to express high levels of human α7 AChRs for drug selection and characterization and possibly to increase α7 expression in vivo.
Directory of Open Access Journals (Sweden)
Rui Liu
2014-01-01
Full Text Available Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A, C-reactive protein (rs1800947 and rs3093059 T/C, methylenetetrahydrofolate reductase (rs1801133, C/T, and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population. Genotyping was performed using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method. When the HNF1A rs7310409 GG homozygote genotype was used as the reference group, both the individual, GA and AA, and combined GA/AA genotypes were associated with an increased risk of LMCAD. This single nucleotide polymorphism (rs7310409 is strongly associated with plasma CRP levels. In conclusion, the present study provides evidence that the HNF1A rs7310409 G/A functional polymorphism may contribute to the risk of LMCAD.
ANIMAL WELFARE FROM MOUSE TO MOOSE--IMPLEMENTING THE PRINCIPLES OF THE 3RS IN WILDLIFE RESEARCH.
Lindsjö, Johan; Fahlman, Åsa; Törnqvist, Elin
2016-04-01
The concept of the 3Rs (replacement, reduction, and refinement) was originally developed for improving laboratory animal welfare and is well known in biomedical and toxicologic research. The 3Rs have so far gained little attention in wildlife research, and there could be several reasons for this. First, researchers may prioritize the welfare of populations and ecosystems over the welfare of individual animals. The effects of research on individual animals can, however, impact welfare and research quality at group and population levels. Second, researchers may find it difficult to apply the 3Rs to studies of free-living wildlife because of the differences between laboratory and wild animals, species, research environment, and purpose and design of the studies. There are, however, several areas where it is possible to transfer the 3R principles to wildlife research, including replacement with noninvasive research techniques, reduction with optimized experimental design, and refinement with better methods of capture, anesthesia, and handling. Third, researchers may not have been trained in applying the 3Rs in wildlife research. This training is needed since ethics committees, employers, journal publishers, and funding agencies increasingly require researchers to consider the welfare implications of their research. In this paper, we compare the principles of the 3Rs in various research areas to better understand the possibilities and challenges of the 3Rs in wildlife research. We emphasize the importance of applying the 3Rs systematically throughout the research process. Based on experiences from laboratory research, we suggest three key factors to enhance implementation of the 3Rs in wildlife research: 1) organizational structure and management, 2) 3R awareness, and 3) research innovation, validation, and implementation. Finally, we encourage an interdisciplinary approach to incorporate the 3R principles in wildlife research. For improved animal welfare and increased
FIRE, A Test Bed for ARIES-RS/AT Advanced Physics and Plasma Technology
International Nuclear Information System (INIS)
Meade, Dale M.
2004-01-01
The overall vision for FIRE [Fusion Ignition Research Experiment] is to develop and test the fusion plasma physics and plasma technologies needed to realize capabilities of the ARIES-RS/AT power plant designs. The mission of FIRE is to attain, explore, understand and optimize a fusion dominated plasma which would be satisfied by producing D-T [deuterium-tritium] fusion plasmas with nominal fusion gains ∼10, self-driven currents of ∼80%, fusion power ∼150-300 MW, and pulse lengths up to 40 s. Achieving these goals will require the deployment of several key fusion technologies under conditions approaching those of ARIES-RS/AT. The FIRE plasma configuration with strong plasma shaping, a double null pumped divertor and all metal plasma-facing components is a 40% scale model of the ARIES-RS/AT plasma configuration. ''Steady-state'' advanced tokamak modes in FIRE with high beta, high bootstrap fraction, and 100% noninductive current drive are suitable for testing the physics of the ARIES-RS/A T operating modes. The development of techniques to handle power plant relevant exhaust power while maintaining low tritium inventory is a major objective for a burning plasma experiment. The FIRE high-confinement modes and AT-modes result in fusion power densities from 3-10 MWm -3 and neutron wall loading from 2-4 MWm -2 which are at the levels expected from the ARIES-RS/AT design studies
Thermonuclear reaction rate of 17O(p,γ)18F
International Nuclear Information System (INIS)
Fox, C.; Iliadis, C.; Champagne, A.E.; Fitzgerald, R.P.; Longland, R.; Newton, J.; Pollanen, J.; Runkle, R.
2005-01-01
The 17 O(p,γ) 18 F and 17 O(p,α) 14 N reactions have a profound influence on hydrogen-burning nucleosynthesis in a number of stellar sites, including red giants, asymptotic giant branch (AGB) stars, massive stars, and classical novae. Previously evaluated thermonuclear rates for both reactions carry large uncertainties. We investigated the proton-capture reaction on 17 O in the bombarding energy range of E p lab = 180-540 keV. We observed a previously undiscovered resonance at E R lab = 193.2 ± 0.9 keV. The resonance strength amounts to (ωγ) pγ (1.2±0.2)x10 -6 eV. With this value, the uncertainties of the 17 O(p,γ) 18 F reaction rates are reduced by orders of magnitude in the peak temperature range of classical novae (T=0.1-0.4 GK). We also report on a reevaluation of the 17 O(p,γ) 18 F reaction rates at lower temperatures that are pertinent to red giants, AGB stars, or massive stars. The present work establishes the 17 O(p,γ) 18 F reaction rates over a temperature range of T= 0.01-1.5 GK with statistical uncertainties of 10-50%. The new recommended reaction rates deviate from the previously accepted values by an order of magnitude around T≅0.2 GK and by factors of 2-3 at T < 0.1 GK
RS-SNP: a random-set method for genome-wide association studies
Directory of Open Access Journals (Sweden)
Mukherjee Sayan
2011-03-01
Full Text Available Abstract Background The typical objective of Genome-wide association (GWA studies is to identify single-nucleotide polymorphisms (SNPs and corresponding genes with the strongest evidence of association (the 'most-significant SNPs/genes' approach. Borrowing ideas from micro-array data analysis, we propose a new method, named RS-SNP, for detecting sets of genes enriched in SNPs moderately associated to the phenotype. RS-SNP assesses whether the number of significant SNPs, with p-value P ≤ α, belonging to a given SNP set is statistically significant. The rationale of proposed method is that two kinds of null hypotheses are taken into account simultaneously. In the first null model the genotype and the phenotype are assumed to be independent random variables and the null distribution is the probability of the number of significant SNPs in greater than observed by chance. The second null model assumes the number of significant SNPs in depends on the size of and not on the identity of the SNPs in . Statistical significance is assessed using non-parametric permutation tests. Results We applied RS-SNP to the Crohn's disease (CD data set collected by the Wellcome Trust Case Control Consortium (WTCCC and compared the results with GENGEN, an approach recently proposed in literature. The enrichment analysis using RS-SNP and the set of pathways contained in the MSigDB C2 CP pathway collection highlighted 86 pathways rich in SNPs weakly associated to CD. Of these, 47 were also indicated to be significant by GENGEN. Similar results were obtained using the MSigDB C5 pathway collection. Many of the pathways found to be enriched by RS-SNP have a well-known connection to CD and often with inflammatory diseases. Conclusions The proposed method is a valuable alternative to other techniques for enrichment analysis of SNP sets. It is well founded from a theoretical and statistical perspective. Moreover, the experimental comparison with GENGEN highlights that it is
Ong, Hing-Huat; Tan, Yen-Nee; Say, Yee-How
2017-01-01
We determined whether single nucleotide polymorphisms (SNPs; rs1761667 and rs1527483) in the fatty acid translocase CD36 gene - a receptor for fatty acids - is associated with oral fat perception (OFP) of different fat contents in custards and commercially-available foods, and obesity measures in Malaysian subjects (n=313; 118 males, 293 ethnic Chinese; 20 ethnic Indians). A 170-mm visual analogue scale was used to assess the ratings of perceived fat content, oiliness and creaminess of 0%, 2%, 6% and 10% fat content-by-weight custards and low-fat/regular versions of commercially-available milk, mayonnaise and cream crackers. Overall, the subjects managed to significantly discriminate the fat content, oiliness and creaminess between low-fat/regular versions of milk and mayonnaise. Females rated the perception of fat content and oiliness of both milks higher, but ethnicity, obesity and adiposity status did not seem to play a role in influencing most of OFP. The overall minor allele frequencies for rs1761667 and rs1527483 were 0.30 and 0.26, respectively. Females and individuals with rs1527483 TT genotype significantly perceived greater creaminess of 10% fat-by-weight custard. Also, individuals with rs1527483 TT genotype and T allele significantly perceived greater fat content of cream crackers, independent of fat concentration. rs1761667 SNP did not significantly affect OFP, except for cream crackers. Both gene variants were also not associated with obesity measures. Taken together, this study supports the notion that CD36 - specifically rs1527483, plays a role in OFP, but not in influencing obesity in Malaysian subjects. Besides, gender is an important factor for OFP, where females had higher sensitivity. Copyright © 2016 Elsevier Inc. All rights reserved.
Kurnaz-Gömleksiz, Ö; Tokat, B; Aslan, E I; Yanar, F; Ermiş-Karaali, Z; Öztürk, O; Yilmaz-Aydoğan, H
2016-07-31
Perlecan (HSPG2) play an important role in the lipoprotein metabolisms. The G allele of the HSPG2-rs3767140 may affect the binding of heparan sulfate (HS) chains and hence cause loss of HS from the basement membrane. HSPG2-rs3767140 was studied in 60 T2DM patients and 109 healthy controls. In diabetic patients HSPG2-rs3767140 T variant allele carriers (TT+GT) have decreased fasting plasma glucose (FPG) and serum LDL-C levels (p=0.071 and p=0.060, respectively) versus GG genotype carriers. Moreover, in both of the two groups in which the T allele carriers HDL-cholesterol levels tend to be high. We investigated that the HSPG2-rs3767140 promoted to the dyslipidemic phenotype in the type 2 diabetes mellitus (T2DM) patients. We suggest that the HSPG2-rs3767140 might be associated with the decreased FPG and LDL-C and with the increased HDL-C in diabetics. Therefore, the HSPG2-rs3767140 might be a protective for the diabetes mellitus due to its ameliorating effect on the dyslipidemic phenotype.
Li, Hao; Zhang, Jianhua; Long, Jiang; Shi, Jiarun; Luo, Yuhui
2018-04-16
The calcium-sensing receptor (CaSR) gene plays an important role in regulating the Ca 2+ balance and reducing the risk for calcium stones. In this study, we evaluated the association of CaSR polymorphisms with calcium nephrolithiasis in the population of Yi nationality in Southwestern China. Biochemical variables were evaluated in 624 calcium nephrolithiasis patients and 470 age-matched healthy controls without a history of nephrolithiasis. CaSR polymorphisms rs7652589, rs1501899, rs1801725 (Ala986Ser), rs1042636 (Arg990Gly) and rs1801726 (Gln1011Glu) were investigated between the calcium nephrolithiasis patients and healthy controls, using direct sequencing. Compared with the healthy controls, serum creatinine and 24-hour urine calcium levels were significantly higher in calcium nephrolithiasis patients. Among these five polymorphisms, the genotypic and allelic frequency distributions of rs7652589 SNP was significantly associated with the risk of calcium nephrolithiasis. However, there were no genotypic or allelic distribution differences for rs1501899, rs1801725, rs1042636, and rs1801726 polymorphisms between calcium nephrolithiasis patients and healthy controls. Moreover, the association between rs7652589 SNP genotypes and the biochemical variables was not found. Our study showed that CaSR rs7652589 polymorphism had a significant effect on the risk of developing calcium nephrolithiasis in the population of Yi nationality in Southwestern China. © 2018 John Wiley & Sons Ltd/University College London.
Aalaei-Andabili, Seyed Hossein; Rezaei, Nima
2016-01-01
Human aging is a complex process with pivotal changes in gene expression of biological pathways. Immune system dysfunction has been recognized as one of the most important abnormalities induced by senescent names immunosenescence. Emerging evidences suggest miR role in immunosenescence. We aimed to systemically review all relevant reports to clearly state miR effects on immunosenescence process. Sensitive electronic searches carried out. Quality assessment has been performed. Since majority of the included studies were laboratory works, and therefore heterogen, we discussed miR effects on immunological aging process nonstatically. Forty-six articles were found in the initial search. After exclusion of 34 articles, 12 studies enrolled to the final stage. We found that miRs have crucial roles in exact function of immune system. MiRs are involved in the regulation of the aging process in the immune system components and target certain genes, promoting or inhibiting immune system reaction to invasion. Also, miRs control life span of the immune system members by regulation of the genes involved in the apoptosis. Interestingly, we found that immunosenescence is controllable by proper manipulation of the various miRs expression. DNA methylation and histone acetylation have been discovered as novel strategies, altering NF-κB binding ability to the miR promoter sites. Effect of miRs on impairment of immune system function due to the aging is emerging. Although it has been accepted that miRs have determinant roles in the regulation of the immunosenescence; however, most of the reports are concluded from animal/laboratory works, suggesting the necessity of more investigations in human.
VfrB Is a Key Activator of the Staphylococcus aureus SaeRS Two-Component System.
Krute, Christina N; Rice, Kelly C; Bose, Jeffrey L
2017-03-01
In previous studies, we identified the fatty acid kinase virulence factor regulator B (VfrB) as a potent regulator of α-hemolysin and other virulence factors in Staphylococcus aureus In this study, we demonstrated that VfrB is a positive activator of the SaeRS two-component regulatory system. Analysis of vfrB , saeR , and saeS mutant strains revealed that VfrB functions in the same pathway as SaeRS. At the transcriptional level, the promoter activities of SaeRS class I ( coa ) and class II ( hla ) target genes were downregulated during the exponential growth phase in the vfrB mutant, compared to the wild-type strain. In addition, saePQRS expression was decreased in the vfrB mutant strain, demonstrating a need for this protein in the autoregulation of SaeRS. The requirement for VfrB-mediated activation was circumvented when SaeS was constitutively active due to an SaeS (L18P) substitution. Furthermore, activation of SaeS via human neutrophil peptide 1 (HNP-1) overcame the dependence on VfrB for transcription from class I Sae promoters. Consistent with the role of VfrB in fatty acid metabolism, hla expression was decreased in the vfrB mutant with the addition of exogenous myristic acid. Lastly, we determined that aspartic acid residues D38 and D40, which are predicted to be key to VfrB enzymatic activity, were required for VfrB-mediated α-hemolysin production. Collectively, this study implicates VfrB as a novel accessory protein needed for the activation of SaeRS in S. aureus IMPORTANCE The SaeRS two-component system is a key regulator of virulence determinant production in Staphylococcus aureus Although the regulon of this two-component system is well characterized, the activation mechanisms, including the specific signaling molecules, remain elusive. Elucidating the complex regulatory circuit of SaeRS regulation is important for understanding how the system contributes to disease causation by this pathogen. To this end, we have identified the fatty acid kinase
[Wetland landscape pattern change based on GIS and RS: a review].
Kong, Fan-Ting; Xi, Min; Li, Yue; Kong, Fan-Long; Chen, Wan
2013-04-01
Wetland is an ecological landscape with most biodiversity in nature, which has unique ecological structure and function, and contains abundant natural resources to provide material guarantee for human's living and development. Wetland landscape pattern is the comprehensive result of various ecological processes, and has become a hot issue in wetland ecological study. At present, the combination of geographic information system (GIS) and remote sensing (RS) technologies is an important way to study the wetland landscape pattern change. This paper reviewed the research progress in the wetland landscape change based on GIS and RS from the aspects of the research methods of wetland landscape pattern, index of wetland landscape pattern, and driving forces of wetland landscape pattern evolution, and discussed the applications of the combination of GIS and RS in monitoring the wetland landscape pattern change, the index selection of wetland landscape pattern, and the driving mechanisms of the combined action of human and nature. Some deficiencies in the current studies were put forward, and the directions of the future-studies were prospected.
Synchronization, TIGoRS, and Information Flow in Complex Systems: Dispositional Cellular Automata.
Sulis, William H
2016-04-01
Synchronization has a long history in physics where it refers to the phase matching of two identical oscillators. This notion has been extensively studied in physics as well as in biology, where it has been applied to such widely varying phenomena as the flashing of fireflies and firing of neurons in the brain. Human behavior, however, may be recurrent but it is not oscillatory even though many physiological systems do exhibit oscillatory tendencies. Moreover, much of human behaviour is collaborative and cooperative, where the individual behaviours may be distinct yet contemporaneous (if not simultaneous) and taken collectively express some functionality. In the context of behaviour, the important aspect is the repeated co-occurrence in time of behaviours that facilitate the propagation of information or of functionality, regardless of whether or not these behaviours are similar or identical. An example of this weaker notion of synchronization is transient induced global response synchronization (TIGoRS). Previous work has shown that TIGoRS is a ubiquitous phenomenon among complex systems, enabling them to stably parse environmental transients into salient units to which they stably respond. This leads to the notion of Sulis machines, which emergently generate a primitive linguistic structure through their dynamics. This article reviews the notion of TIGoRS and its expression in several complex systems models including tempered neural networks, driven cellular automata and cocktail party automata. The emergent linguistics of Sulis machines are discussed. A new class of complex systems model, the dispositional cellular automaton is introduced. A new metric for TIGoRS, the excess synchronization, is introduced and applied to the study of TIGoRS in dispositional cellular automata. It is shown that these automata exhibit a nonlinear synchronization response to certain perturbing transients.
Expanding the three Rs to meet new challenges in humane animal experimentation.
Schuppli, Catherine A; Fraser, David; McDonald, Michael
2004-11-01
The Three Rs are the main principles used by Animal Ethics Committees in the governance of animal experimentation, but they appear not to cover some ethical issues that arise today. These include: a) claims that certain species should be exempted on principle from harmful research; b) increased emphasis on enhancing quality of life of research animals; c) research involving genetically modified (GM) animals; and d) animals bred as models of disease. In some cases, the Three Rs can be extended to cover these developments. The burgeoning use of GM animals in science calls for new forms of reduction through improved genetic modification technology, plus continued attention to alternative approaches and cost-benefit analyses that include the large numbers of animals involved indirectly. The adoption of more expanded definitions of refinement that go beyond minimising distress will capture concerns for enhancing the quality of life of animals through improved husbandry and handling. Targeting refinement to the unpredictable effects of gene modification may be difficult; in these cases, careful attention to monitoring and endpoints are the obvious options. Refinement can also include sharing data about the welfare impacts of gene modifications, and modelling earlier stages of disease, in order to reduce the potential suffering caused to disease models. Other issues may require a move beyond the Three Rs. Certain levels of harm, or numbers and use of certain species, may be unacceptable, regardless of potential benefits. This can be addressed by supplementing the utilitarian basis of the Three Rs with principles based on deontological and relational ethics. The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research.
PDYN rs2281285 variant association with drinking to avoid emotional or somatic discomfort.
Directory of Open Access Journals (Sweden)
Ulrich W Preuss
Full Text Available One of the proposed psychobiological pathways of craving attributes the desire for drinking in the context of tension, discomfort or unpleasant emotions, to "negative" (or "relief" craving. The aim of this study was to replicate a previously reported association of the PDYN rs2281285 variant with negative craving using a different phenotyping approach.The TaqMan® Genotyping Assay was used to genotype the rs2281285 variant in 417 German alcohol-dependent subjects. The presence of negative/relief craving was assessed by asking if participants ever ingested alcohol to avoid unwanted emotional or somatic discomfort.The minor allele of rs2281285 was associated with an increased risk of drinking to avoid/escape unwanted emotional or somatic events (OR=2.29, 95% CI=1.08-4.85, p=0.0298.Despite the use of a different phenotyping approach to the measurement of negative craving, our results confirm the association between negative craving and PDYN rs2281285. Genetic markers of negative craving may help to identify subgroups of alcohol-dependent individuals vulnerable to relapse in the context of negative emotions or somatic discomfort, leading to the development of specifically tailored treatment strategies.
Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study
The objective of this study is to examine a functional variant (rs6265) in the BDNF gene interacting with dietary intake modulate obesity traits in the Boston Puerto Rican Health Study population. BDNF rs6265 was genotyped in 1147 Puerto Ricans (aged 45-75 years), and examined for association with o...
Thermonuclear targets for direct-drive ignition by a megajoule laser pulse
Energy Technology Data Exchange (ETDEWEB)
Bel’kov, S. A.; Bondarenko, S. V. [Russian Federal Nuclear Center, All-Russia Research Institute of Experimental Physics (Russian Federation); Vergunova, G. A. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Garanin, S. G. [Russian Federal Nuclear Center, All-Russia Research Institute of Experimental Physics (Russian Federation); Gus’kov, S. Yu., E-mail: guskov@sci.lebedev.ru; Demchenko, N. N.; Doskoch, I. Ya.; Kuchugov, P. A. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation); Zmitrenko, N. V. [Russian Academy of Sciences, Keldysh Institute of Applied Mathematics (Russian Federation); Rozanov, V. B.; Stepanov, R. V.; Yakhin, R. A. [Russian Academy of Sciences, Lebedev Physical Institute (Russian Federation)
2015-10-15
Central ignition of a thin two-layer-shell fusion target that is directly driven by a 2-MJ profiled pulse of Nd laser second-harmonic radiation has been studied. The parameters of the target were selected so as to provide effective acceleration of the shell toward the center, which was sufficient for the onset of ignition under conditions of increased hydrodynamic stability of the ablator acceleration and compression. The aspect ratio of the inner deuterium-tritium layer of the shell does not exceed 15, provided that a major part (above 75%) of the outer layer (plastic ablator) is evaporated by the instant of maximum compression. The investigation is based on two series of numerical calculations that were performed using one-dimensional (1D) hydrodynamic codes. The first 1D code was used to calculate the absorption of the profiled laser-radiation pulse (including calculation of the total absorption coefficient with allowance for the inverse bremsstrahlung and resonance mechanisms) and the spatial distribution of target heating for a real geometry of irradiation using 192 laser beams in a scheme of focusing with a cubo-octahedral symmetry. The second 1D code was used for simulating the total cycle of target evolution under the action of absorbed laser radiation and for determining the thermonuclear gain that was achieved with a given target.
Directory of Open Access Journals (Sweden)
Jürgen Glas
Full Text Available BACKGROUND: Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE and rheumatoid arthritis (RA, indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD in a large patient and control cohort. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD, 464 patients with ulcerative colitis (UC, and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238. In addition, a detailed genotype-phenotype analysis was performed. Our analysis revealed an association of the STAT4 SNP rs7574865 with overall decreased susceptibility to CD (p = 0.047, OR 0.86 [95% CI 0.74-0.99]. However, compared to CD patients carrying the wild type genotype, the STAT4 SNP rs7574865 was significantly associated with early CD onset (p = 0.021 and colonic CD (p = 0.008; OR = 4.60, 95% CI 1.63-12.96. For two other STAT4 variants, there was a trend towards protection against CD susceptibility (rs7568275, p = 0.058, OR 0.86 [95% CI 0.74-1.00]; rs10174238, p = 0.057, OR 0.86 [95% CI 0.75-1.00]. In contrast, we did not observe any association with UC susceptibility. Evidence for weak gene-gene interaction of STAT4 with the IL23R SNP rs11209026 was lost after Bonferroni correction. CONCLUSIONS/SIGNIFICANCE: Our results identified the STAT4 SNP rs7574865 as a disease-modifying gene variant in colonic CD. However, in contrast to SLE and RA, the effect of rs7574865 on CD susceptibility is only weak.
Glas, Jürgen; Seiderer, Julia; Nagy, Melinda; Fries, Christoph; Beigel, Florian; Weidinger, Maria; Pfennig, Simone; Klein, Wolfram; Epplen, Jörg T; Lohse, Peter; Folwaczny, Matthias; Göke, Burkhard; Ochsenkühn, Thomas; Diegelmann, Julia; Müller-Myhsok, Bertram; Roeske, Darina; Brand, Stephan
2010-04-29
Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort. Genomic DNA from 2704 individuals of Caucasian origin including 857 patients with Crohn's disease (CD), 464 patients with ulcerative colitis (UC), and 1383 healthy, unrelated controls was analyzed for seven SNPs in the STAT4 gene (rs11889341, rs7574865, rs7568275, rs8179673, rs10181656, rs7582694, rs10174238). In addition, a detailed genotype-phenotype analysis was performed. Our analysis revealed an association of the STAT4 SNP rs7574865 with overall decreased susceptibility to CD (p = 0.047, OR 0.86 [95% CI 0.74-0.99]). However, compared to CD patients carrying the wild type genotype, the STAT4 SNP rs7574865 was significantly associated with early CD onset (p = 0.021) and colonic CD (p = 0.008; OR = 4.60, 95% CI 1.63-12.96). For two other STAT4 variants, there was a trend towards protection against CD susceptibility (rs7568275, p = 0.058, OR 0.86 [95% CI 0.74-1.00]; rs10174238, p = 0.057, OR 0.86 [95% CI 0.75-1.00]). In contrast, we did not observe any association with UC susceptibility. Evidence for weak gene-gene interaction of STAT4 with the IL23R SNP rs11209026 was lost after Bonferroni correction. Our results identified the STAT4 SNP rs7574865 as a disease-modifying gene variant in colonic CD. However, in contrast to SLE and RA, the effect of rs7574865 on CD susceptibility is only weak.
Insect nicotinic acetylcholine receptors (nAChRs): Important amino ...
African Journals Online (AJOL)
STORAGESEVER
2008-12-29
Dec 29, 2008 ... nAChRs within the insect central nervous system has led to the development of insecticides targeting .... binding protein (AChBP), a homopentameric structural and functional homolog of ..... of the honey bee, Apis mellifera.
The RS-485 communication system design of the waste steel radioactivity detector system
International Nuclear Information System (INIS)
Zhang Yongli
2014-01-01
The importance and schematic structure of the waste steel radioactivity detector system is given firstly in this paper, and then the RS-485 communication system design including the circuit and program of the waste steel radioactivity detector system is provided. The test result of RS-485 communication system is also introduced, that shows the design completely meets the requirements of the waste steel radioactivity detector system. (author)
Directory of Open Access Journals (Sweden)
Nara Rejane Zamberlan dos Santos
2012-04-01
Full Text Available ResumoUm estudo foi realizado com os turistas da cidade de Canela (RS, em quatro períodos do ano (julho-outubro, dezembro e fevereiro, com o objetivo de valorar 22 fotos (substitutos da paisagem da Floresta Nacional de Canela (RS, cuja escala de ponderação era variável de 1 a 5, correspondendo a classes de qualidade da paisagem de muito baixa a muito alta, respectivamente. Os resultados mostram que as mulheres são mais perceptivas do que os homens na análise de paisagens. Os menores valores médios valorados correspondem aos substitutos da classe baixa (2,74 e os mais altos, à classe alta de qualidade da paisagem (4,61. Por meio da Análise de Agrupamento Hierárquico, são observados dois grupos, sendo o primeiro, formado por mulheres de 15 a mais de 70 anos e jovens de 15 a 20 anos, do sexo masculino; e o segundo grupo, pelos demais homens.AbstractA study was carried out with the tourists of the city of Canela (RS, in four periods of the year (July, October, December and February, in order to value 22 photographs (landscape substitutes of the National Forest of Canela (RS, which weighting scale varied from 1 to 5. it was corresponding to very low to very high landscape classifications. The results show that women are more perceptive than men in landscape analysis. The lowest average values given correspond with low –class substitutes (2.74 and the highest with high quality landscapes (4.61. Through hierarchical group analysis were shown two groups, the first formed by women from 15 to over 70 years of age and young men of 15 to 20 years of age and second group by older men.
Research programme on controlled thermonuclear fusion. Synthesis report 2011
International Nuclear Information System (INIS)
Vaucher, C.; Tran, M. Q.; Villard, L.; Marot, L.
2012-01-01
Since 1978, research on thermonuclear fusion in Switzerland is closely related to the research programme of the European Atomic Energy Community (EURATOM). The Swiss projects tackle aspects of plasma physics and fusion technology. Switzerland participates to the construction and operation of the Joint European Torus (JET), which started operation again in 2011. The International Thermonuclear Experimental Reactor (ITER) is the last step before DEMO, a prototype fusion reactor able to deliver electricity and demonstrate the economic viability of fusion energy. The 'Centre de Recherches en Physique des Plasmas' (CRPP) of the EPFL went on with its participation to the scientific and technological programme of EURATOM. Researches are carried out essentially on 2 sites: (i) at EPFL, where topics dealt with include the physics of magnetic confinement studied using the Variable Configuration Tokamak (TCV), the basic experiment TORPEX, theory and numerical modelling, and the technology of plasma heating and current generation by hyper-frequency waves; (ii) at the Paul Scherrer Institute (PSI), where activities are devoted to superconductivity and structure materials. Thanks to the large flexibility of the TCV design and operation modus, plasmas of different shapes can be created and controlled, what is a very useful option to verify numerical simulation results. Besides, the injection of millimetre waves allows directing the injected power according to specific profiles. In the TCV it could be demonstrated for the first time that the injection of Electronic Cyclotronic Heating (ECH) waves is able to double the frequency of so-called 'Edge Localized Modes' (ELM), reducing by a factor of 2 the energy expelled by each ELM. In particular, it was possible to considerably reduce the statistical dispersion of the repetition frequency of ELM, and to avoid the appearance of gigantic ELM that are particularly harmful for reactor operation. The effect of plasma internal relaxation
Energy Technology Data Exchange (ETDEWEB)
none,
1987-04-01
The Summit Members' Working Group on Controlled Thermonuclear Fusion (Fusion Working Group (FWG)) was established in 1983 in response to the Declaration of the Heads of State and Government at the Versailles Economic Summit meeting of 1982, and in response to the subsequent report of the Working Group in Technology, Growth and Employment (TGE) as endorsed at the Williamsburg Summit meeting, 1983. This document contains the complete written record of each of the three FWG meetings which include the minutes, lists of attendees, agendas, statements, and summary conclusions as well as the full reports of the Technical Working Party. In addition, there is a pertinent exchange of correspondence between FWG members on the role of the Technical Working Party and a requested background paper on the modalities associated with a possible future ETR project.
Energy Technology Data Exchange (ETDEWEB)
Itahashi, T; Takahisa, K; Fujiwara, M; Toki, H; Ejiri, H [Osaka Univ., Ibaraki (Japan). Research Center for Nuclear Physics; Ohsumi, H; Komori, M
1997-03-01
A compact accelerator with high current ion source, low energy beam transport elements and windowless gas target was designed to investigate the thermonuclear reaction cross section. The idea of this project focused on the cross section measurement of the fusion reaction data {sup 3}He+{sup 3}He-{sup 4}He+p+p at 25keV. The system will be installed in Otoh Cosmo Observatory (1270m.w.e.) to get rid of the huge cosmic and environmental background. It consists of NANOGUN ECR ion source, focusing elements made of permanent magnets window less {sup 3}He gas target and/or He{sup 3} plasma target and detector telescopes with low noise and low background. Requirements for these were discussed technically and various ideas were proposed. (author)
THE {sup 7}Be ii RESONANCE LINES IN TWO CLASSICAL NOVAE V5668 SGR AND V2944 OPH
Energy Technology Data Exchange (ETDEWEB)
Tajitsu, Akito [Subaru Telescope, National Astronomical Observatory of Japan, 650 North A’ohoku Place, Hilo, HI 96720 (United States); Sadakane, Kozo [Astronomical Institute, Osaka Kyoiku University, Asahigaoka, Kashiwara, Osaka 582-8582 (Japan); Naito, Hiroyuki [Nayoro Observatory, 157-1 Nisshin, Nayoro, Hokkaido 096-0066 (Japan); Arai, Akira; Kawakita, Hideyo [Koyama Astronomical Observatory, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555 (Japan); Aoki, Wako, E-mail: tajitsu@naoj.org [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan)
2016-02-20
We report spectroscopic observations of the resonance lines of singly ionized {sup 7}Be in the blueshifted absorption line systems found in the post-outburst spectra of two classical novae—V5668 Sgr (Nova Sagittarii 2015 No. 2) and V2944 Oph (Nova Ophiuchi 2015). The unstable isotope {sup 7}Be should have been created during the thermonuclear runaway (TNR) of these novae and decayed to form {sup 7}Li within a short period (a half-life of 53.22 days). These confirmations of {sup 7}Be are the second and the third ones following the first case found in V339 Del by Tajitsu et al. The blueshifted absorption line systems in both novae are clearly divided into two velocity components, both of which contain {sup 7}Be. This means that the absorbing gases in both velocity components consist of products of TNR. We estimated the amounts of {sup 7}Be produced during the outbursts of both novae and concluded that significant {sup 7}Li should have been created. These findings strongly suggest that the explosive production of {sup 7}Li via the reaction {sup 3}He(α,γ){sup 7}Be and its subsequent decay to {sup 7}Li occurs frequently among classical novae and contributes to the process of Galactic Li enrichment.
Directory of Open Access Journals (Sweden)
Byung Moo Lee
2017-12-01
Full Text Available Massive multiple-input multiple-output (MIMO systems can be applied to support numerous internet of things (IoT devices using its excessive amount of transmitter (TX antennas. However, one of the big obstacles for the realization of the massive MIMO system is the overhead of reference signal (RS, because the number of RS is proportional to the number of TX antennas and/or related user equipments (UEs. It has been already reported that antenna group-based RS overhead reduction can be very effective to the efficient operation of massive MIMO, but the method of deciding the number of antennas needed in each group is at question. In this paper, we propose a simplified determination scheme of the number of antennas needed in each group for RS overhead reduced massive MIMO to support many IoT devices. Supporting many distributed IoT devices is a framework to configure wireless sensor networks. Our contribution can be divided into two parts. First, we derive simple closed-form approximations of the achievable spectral efficiency (SE by using zero-forcing (ZF and matched filtering (MF precoding for the RS overhead reduced massive MIMO systems with channel estimation error. The closed-form approximations include a channel error factor that can be adjusted according to the method of the channel estimation. Second, based on the closed-form approximation, we present an efficient algorithm determining the number of antennas needed in each group for the group-based RS overhead reduction scheme. The algorithm depends on the exact inverse functions of the derived closed-form approximations of SE. It is verified with theoretical analysis and simulation that the proposed algorithm works well, and thus can be used as an important tool for massive MIMO systems to support many distributed IoT devices.
The Canadian initiative to bring the international thermonuclear experimental reactor to Canada
International Nuclear Information System (INIS)
James, R.A.
1996-01-01
The International Thermonuclear Experimental Reactor (ITER) is the next step in fusion research. It is expected to be the last major experimental facility, before the construction of a prototype commercial reactor. The Engineering Design Activities (EDA) of ITER are being funded by the USA, Japan, the Russian Federation, and the European Union, with each of the major parties contributing about 25% of the cost. Canada participates as part of the European coalition. The EDA is due to be completed in 1998, and the major funding partners are preparing for the decision on the siting and construction of ITER. The Canadian Fusion Fuels Technology Project (CFFTP) formed a Canadian ITER Siting Task Group to study siting ITER in Canada. The study indicated that hosting ITER would provide significant benefits, both technological and economic, to Canada. We have also confirmed that there would be substantial benefits to the ITER Project. CFFTP then formed a Canadian ITER Siting Board, with representation from a broad range of stakeholders, to champion, 'Canada as Host'. This paper briefly outlines the ITER Project, and the benefits to both Canada and the Project of a Canadian site. With this as background, the paper discusses the international scene and assesses Canada's prospects of being chosen to host ITER. (author)
The Use of Systematic Reviews and Reporting Guidelines to Advance the Implementation of the 3Rs
Avey, Marc T; Fenwick, Nicole; Griffin, Gilly
2015-01-01
In 1959, Russell and Burch published The Principles of Humane Experimental Technique, which included concrete advice on factors that they considered would govern progress in the implementation of these principles (enunciated as the 3Rs [Replacement, Reduction, and Refinement in animal-based studies]). One challenge to the implementation of the 3Rs was identified as information retrieval. Here, we further explore this challenge—the need for ‘research on research’—and the role that systematic reviews and reporting guidelines can play in implementation of the 3Rs. First, we examine the 2-fold nature of the challenge of information retrieval: 1) the identification of relevant publications spread throughout a large population of nonrelevant publications and 2) the incomplete reporting of relevant details within those publications. Second, we evaluate how systematic reviews and reporting guidelines can be used generally to address this challenge. Third, we assess the explicit reporting of the 3Rs in a cohort of preclinical animal systematic reviews. Our results show that Reduction methods are the most commonly reported by authors of systematic reviews but that, in general, reporting on how findings relate to the 3Rs is limited at best. Although systematic reviews are excellent tools for resolving the challenge of information retrieval, their utility for making progress in implementation of the 3Rs may be limited unless authors improve their reporting of these principles. PMID:25836961
A systems immunology approach identifies the collective impact of 5 miRs in Th2 inflammation.
Kılıç, Ayşe; Santolini, Marc; Nakano, Taiji; Schiller, Matthias; Teranishi, Mizue; Gellert, Pascal; Ponomareva, Yuliya; Braun, Thomas; Uchida, Shizuka; Weiss, Scott T; Sharma, Amitabh; Renz, Harald
2018-06-07
Allergic asthma is a chronic inflammatory disease dominated by a CD4+ T helper 2 (Th2) cell signature. The immune response amplifies in self-enforcing loops, promoting Th2-driven cellular immunity and leaving the host unable to terminate inflammation. Posttranscriptional mechanisms, including microRNAs (miRs), are pivotal in maintaining immune homeostasis. Since an altered expression of various miRs has been associated with T cell-driven diseases, including asthma, we hypothesized that miRs control mechanisms ensuring Th2 stability and maintenance in the lung. We isolated murine CD4+ Th2 cells from allergic inflamed lungs and profiled gene and miR expression. Instead of focusing on the magnitude of miR differential expression, here we addressed the secondary consequences for the set of molecular interactions in the cell, the interactome. We developed the Impact of Differential Expression Across Layers, a network-based algorithm to prioritize disease-relevant miRs based on the central role of their targets in the molecular interactome. This method identified 5 Th2-related miRs (mir27b, mir206, mir106b, mir203, and mir23b) whose antagonization led to a sharp reduction of the Th2 phenotype. Overall, a systems biology tool was developed and validated, highlighting the role of miRs in Th2-driven immune response. This result offers potentially novel approaches for therapeutic interventions.
Malinowski, Damian; Paradowska-Gorycka, Agnieszka; Safranow, Krzysztof; Pawlik, Andrzej
2017-08-01
Interleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the IL-21 gene may alter the synthesis of IL-21. The aim of this study was to examine IL-21 and IL-21R polymorphisms in patients with RA. We examined 422 patients with RA and 338 healthy controls. Single nucleotide polymorphisms (SNPs) within the IL-21 (rs6822844 G>T, rs6840978 C>T, rs2221903 T>C) and IL-21R (rs2285452 G>A) genes were genotyped using TaqMan genotyping assays. There were no statistically significant differences in the distribution of studied genotypes and alleles between RA patients and the control group. To examine whether IL-21 polymorphisms affect disease activity in RA patients, we compared the distribution of IL-21 genotypes between patients with DAS28 ≤ 2.5 (patients with remission of disease symptoms) and patients with DAS28 > 2.5 (patients with active RA). Among patients with DAS28 > 2.5, increased prevalence of rs2221903 CT and CC genotypes was observed (OR = 1.54; 95% CI: 1.04-2.28; p = 0.035). The results of this study suggest that IL-21 and IL-21R gene polymorphisms are not risk loci for RA susceptibility, whereas the IL-21 rs2221903 polymorphism is associated with disease activity.
Czech Academy of Sciences Publication Activity Database
Plesník, J.; Šerý, Omar; Khan, A. S.; Bielik, P.; Khan, N. A.
2018-01-01
Roč. 119, č. 4 (2018), s. 472-478 ISSN 0007-1145 R&D Projects: GA MZd(CZ) NV16-29900A Institutional support: RVO:67985904 Keywords : CD36 * fat taste * genetic polymorphism * rs1527483 Subject RIV: ED - Physiology OBOR OECD: Physiology (including cytology) Impact factor: 3.706, year: 2016
Energy Technology Data Exchange (ETDEWEB)
Keek, L. [X-ray Astrophysics Laboratory, Astrophysics Science Division, NASA/GSFC, Greenbelt, MD 20771 (United States); Heger, A., E-mail: laurens.keek@nasa.gov [Monash Center for Astrophysics, School of Physics and Astronomy, Monash University, Victoria, 3800 (Australia)
2017-06-20
Thermonuclear flashes of hydrogen and helium accreted onto neutron stars produce the frequently observed Type I X-ray bursts. It is the current paradigm that almost all material burns in a burst, after which it takes hours to accumulate fresh fuel for the next burst. In rare cases, however, bursts are observed with recurrence times as short as minutes. We present the first one-dimensional multi-zone simulations that reproduce this phenomenon. Bursts that ignite in a relatively hot neutron star envelope leave a substantial fraction of the fuel unburned at shallow depths. In the wake of the burst, convective mixing events driven by opacity bring this fuel down to the ignition depth on the observed timescale of minutes. There, unburned hydrogen mixes with the metal-rich ashes, igniting to produce a subsequent burst. We find burst pairs and triplets, similar to the observed instances. Our simulations reproduce the observed fraction of bursts with short waiting times of ∼30%, and demonstrate that short recurrence time bursts are typically less bright and of shorter duration.
International Nuclear Information System (INIS)
Tazhibayeva, I.; Shestakov, V.; Cherepnin, Yu.S.
2001-01-01
The investigations in the area of structural materials for fusion program initiated within the framework of ITER project in the Republic of Kazakhstan are devoted basically in the following direction: to studying the behaviour of hydrogen isotopes in structural elements of the first wall and the divertor in conditions simulating real conditions of material operation, accident situations arising during steam interaction with the beryllium armour of the first wall during accidental coolant loss, to establish an experimental facility for study aspects of tritium safety of thermonuclear installations, for example, levels of tritium accumulation and release; efficiency of barrier layers and protective coating; influence of brazing and welding zones on tritium permeation. The work on determination of tritium release from lead/lithium eutectic alloy by mass-spectrometry method and the development of permeation barriers has begun. At present, work has begun to create Kazakhstan's own tokamak type reactor for investigation of the behaviour of various first wall materials and divertor plates during normal and accident conditions. The concept of spherical tokamak will be used in the construction of KTM reactor. (author)