Cost-effectiveness of rosuvastatin in comparison with generic atorvastatin and simvastatin in a Swedish population at high risk of cardiovascular events

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Gandhi SK

2012-01-01

Full Text Available Sanjay K Gandhi1, Marie M Jensen2, Kathleen M Fox3, Lee Smolen4, Anders G Olsson5, Thomas Paulsson61AstraZeneca LP, Wilmington, DE, USA; 2AstraZeneca, Lund, Sweden; 3Strategic HealthCare Solution, Monkton, MD; 4Medical Decision Modeling Inc, Indianapolis, IN, USA; 5Department of Medical and Health Sciences, Linkoping University, and Stockholm Heart Center, Stockholm; 6AstraZeneca, Sodertalje, SwedenBackground: To assess the long-term cost-effectiveness of rosuvastatin therapy compared with generic simvastatin and generic atorvastatin in reducing the incidence of cardiovascular events and mortality in a Swedish population with Framingham risk ≥20%.Methods: A probabilistic Monte Carlo simulation model based on data from JUPITER (the Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin was used to estimate the long-term cost-effectiveness of rosuvastatin 20 mg daily versus simvastatin or atorvastatin 40 mg for the prevention of cardiovascular death and morbidity. The three-stage model included cardiovascular event prevention simulating the 4 years of JUPITER, initial prevention beyond the trial, and subsequent cardiovascular event prevention. A Swedish health care payer perspective (direct costs only was modeled for a lifetime horizon, with 2008/2009 as the costing period. Univariate and probabilistic sensitivity analyses were performed.Results: The incremental cost per quality-adjusted life-year (QALY gained with rosuvastatin 20 mg over simvastatin or atorvastatin 40 mg ranged from SEK88,113 (rosuvastatin 20 mg versus simvastatin 40 mg; Framingham risk ≥30%; net avoidance of 34 events/1000 patients to SEK497,542 (versus atorvastatin 40 mg: Framingham risk ≥20%; net avoidance of 11 events/1000 patients over a lifetime horizon. Probabilistic sensitivity analyses indicated that at a willingness-to-pay threshold of SEK500,000/QALY, rosuvastatin 20 mg would be cost-effective for approximately 75%–85

Cholesterol Efflux Capacity, High-Density Lipoprotein Particle Number, and Incident Cardiovascular Events: An Analysis From the JUPITER Trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin).

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Khera, Amit V; Demler, Olga V; Adelman, Steven J; Collins, Heidi L; Glynn, Robert J; Ridker, Paul M; Rader, Daniel J; Mora, Samia

2017-06-20

Recent failures of drugs that raised high-density lipoprotein (HDL) cholesterol levels to reduce cardiovascular events in clinical trials have led to increased interest in alternative indices of HDL quality, such as cholesterol efflux capacity, and HDL quantity, such as HDL particle number. However, no studies have directly compared these metrics in a contemporary population that includes potent statin therapy and low low-density lipoprotein cholesterol. HDL cholesterol levels, apolipoprotein A-I, cholesterol efflux capacity, and HDL particle number were assessed at baseline and 12 months in a nested case-control study of the JUPITER trial (Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin), a randomized primary prevention trial that compared rosuvastatin treatment to placebo in individuals with normal low-density lipoprotein cholesterol but increased C-reactive protein levels. In total, 314 cases of incident cardiovascular disease (CVD) (myocardial infarction, unstable angina, arterial revascularization, stroke, or cardiovascular death) were compared to age- and gender-matched controls. Conditional logistic regression models adjusting for risk factors evaluated associations between HDL-related biomarkers and incident CVD. Cholesterol efflux capacity was moderately correlated with HDL cholesterol, apolipoprotein A-I, and HDL particle number (Spearman r = 0.39, 0.48, and 0.39 respectively; P capacity (OR/SD, 0.89; 95% CI, 0.72-1.10; P =0.28), HDL cholesterol (OR/SD, 0.82; 95% CI, 0.66-1.02; P =0.08), or apolipoprotein A-I (OR/SD, 0.83; 95% CI, 0.67-1.03; P =0.08). Twelve months of rosuvastatin (20 mg/day) did not change cholesterol efflux capacity (average percentage change -1.5%, 95% CI, -13.3 to +10.2; P =0.80), but increased HDL cholesterol (+7.7%), apolipoprotein A-I (+4.3%), and HDL particle number (+5.2%). On-statin cholesterol efflux capacity was inversely associated with incident CVD (OR/SD, 0.62; 95% CI, 0

Evidence for a pharmacokinetic interaction between eslicarbazepine and rosuvastatin: Potential effects on xenobiotic transporters.

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Gidal, Barry E; Mintzer, Scott; Schwab, Matthias; Schutz, Ralph; Kharidia, Jahnavi; Blum, David; Grinnell, Todd; Sunkaraneni, Soujanya

2017-09-01

Patients with partial-onset seizures and comorbid cardiovascular disease may concomitantly receive eslicarbazepine acetate (ESL), an antiepileptic drug, and rosuvastatin, an HMG-CoA reductase inhibitor. This study evaluated the effect of multiple-dose ESL on the pharmacokinetic (PK) parameters of a single dose of rosuvastatin in healthy subjects. This was a Phase I, single-center, fixed-sequence, open-label study. Healthy subjects received two treatments, in sequence. Treatment A: a single 40mg oral dose of rosuvastatin on Day 1, followed by a washout period (Days 1-4); treatment B: titration of ESL (400-800mg once daily) on Days 5-18, followed by ESL 1200mg once daily on Days 19-35, with a single dose of rosuvastatin (40mg) on Day 32. Subjects then entered a 2-week follow-up period. Plasma concentrations of rosuvastatin were quantified for PK analyses. Safety and tolerability were assessed throughout the study. Thirty-three healthy subjects were enrolled and 30 completed the study. Mean rosuvastatin (standard deviation) t 1/2 was similar when rosuvastatin was used concomitantly with ESL and when it was used alone (26.5 [16.3]h, and 22.4 [9.5]h, respectively). The geometric least squares mean ratios (90% confidence intervals) of rosuvastatin exposure levels between rosuvastatin used concomitantly with ESL and rosuvastatin used alone were as follows: C max , 64.0% (55.9-73.3%); AUC (0-∞) , 63.0% (57.1-69.4%); and AUC (0-last) , 60.9% (55.2-67.1%). Concomitant use of ESL and rosuvastatin was generally well tolerated. Rosuvastatin exposure was 36-39% lower with steady-state administration of ESL, potentially due to reduced oral bioavailability of rosuvastatin. Consequently, when rosuvastatin is used with ESL, a rosuvastatin dose adjustment may be necessary if a clinically significant change in lipids is noted. Copyright © 2017. Published by Elsevier B.V.

Genotoxicity evaluation of HMG CoA reductase inhibitor rosuvastatin.

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Berber, Ahmet Ali; Celik, Mustafa; Aksoy, Hüseyin

2014-07-01

The genotoxic potential of rosuvastatin as one of the statin drugs was assessed by chromosomal aberrations (CAs), micronucleus (MN) and DNA damage by comet assay in the human peripheral blood lymphocytes. Rosuvastatin was used at concentrations of 0.0625, 0.125, 0.25, 0.5 and 1 µg/mL for these in vitro assays. In all assays, a negative and positive control were also included. CA frequencies were significantly increased in all concentrations at 24 hours and significantly increased in all concentrations except 0.0625 µg/mL at 48 hours, compared to the negative control. Rosuvastatin has a decreased mitotic index (MI) at 0.5- and 1-µg/mL concentrations at 24 hours and at 0.25, 0.5 and 1 µg/mL at 48 hours. A significant increase was observed for induction of MN in all treatments, compared to the negative control. Cytokinesis-block proliferation indices were not affected by treatments with rosuvastatin. In the comet assay, significant increases in comet tail length and tail moment were observed at 0.0625-, 0.5- and 1-µg/mL concentrations. Comet intensity was significantly increased in all concentrations except 0.0625 µg/mL. According to these results, rosuvastatin is cytotoxic and clastogenic/aneugenic in human peripheral lymphocytes. Further studies should be conducted in other test systems to evaluate the full genotoxic potential of rosuvastatin.

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects.

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Jung, Jin Ah; Lee, Soo-Yun; Kim, Jung-Ryul; Ko, Jae-Wook; Jang, Seong Bok; Nam, Su Youn; Huh, Wooseong

2015-01-01

Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects. Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day), valsartan (160 mg/day), and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study. Plasma concentrations of rosuvastatin, N-desmethyl rosuvastatin, and valsartan were determined using validated high-performance liquid chromatography with tandem mass spectrometry. Lipid profiles and vital signs (systolic and diastolic blood pressure and pulse rate) were measured for the pharmacodynamic assessment. For rosuvastatin, the geometric mean ratios (90% confidence intervals [CIs]) of coadministration to mono-administration were 0.8809 (0.7873-0.9857) for maximum plasma concentration at steady state and 0.9151 (0.8632-0.9701) for area under the concentration-time curve (AUC) over a dosing interval at steady state. For valsartan, the geometric mean ratios (90% CIs) of those were 0.9300 (0.7946-1.0884) and 1.0072 (0.8893-1.1406), respectively. There were no significant differences in the metabolic ratio of N-desmethyl rosuvastatin AUC to rosuvastatin AUC between coadministration and rosuvastatin alone. No interaction was found in terms of systolic or diastolic blood pressure or lipid profiles. Combined treatment with valsartan and rosuvastatin was generally well tolerated without serious adverse events. The pharmacokinetic profiles of rosuvastatin and valsartan in combination were comparable with those of rosuvastatin and valsartan administered individually, suggesting that their individual pharmacokinetics were not affected by their

Impact of the JUPITER trial on statin prescribing for primary prevention.

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Teng, Jennifer F T; Gomes, Tara; Camacho, Ximena; Grundy, Scott; Juurlink, David N; Mamdani, Muhammad M

2014-01-01

As the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial identified a new population of individuals with cholesterol levels below traditional treatment thresholds but with elevated high-sensitivity C-reactive protein (hs-CRP) levels who may benefit from primary prevention with statin therapy, we sought to evaluate the impact of this trial on the incident prescription rates of rosuvastatin alone as well as all statins in a primary prevention population. Population-based, cross-sectional time-series analysis. Administrative health care databases in Ontario, Canada. A total of 299,809 incident statin users 66 years or older were identified during the study period, from January 1, 2003, to March 31, 2011, who were prescribed statin therapy for primary prevention. We evaluated the incident rate of rosuvastatin and all statin use during each quarter of the study period. Overall, no significant trends in all incident statin use were observed (p=0.99). Furthermore, no significant differences were observed in incident rates of rosuvastatin (p=0.21) or all statin (p=0.41) use after the publication of the JUPITER trial. Despite the lack of impact of the JUPITER trial on rosuvastatin or all statin utilization, the relative market share of rosuvastatin increased from 9% to 65% over the study period. The publication of the JUPITER trial did not significantly affect trends in overall statin and rosuvastatin prescribing patterns for primary prevention in this study. Increases in the relative market share of rosuvastatin may be attributed to the impact of the pharmaceutical industry on prescribing patterns. Our results highlight the need to further improve the integration of evidence-based prescribing into cost-effective clinical practice. © 2013 Pharmacotherapy Publications, Inc.

Rosuvastatin safety: An experimental study of myotoxic effects and mitochondrial alterations in rats.

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El-Ganainy, Samar O; El-Mallah, Ahmed; Abdallah, Dina; Khattab, Mahmoud M; Mohy El-Din, Mahmoud M; El-Khatib, Aiman S

2017-01-04

Myopathy is the most commonly reported adverse effect of statins. All statins are associated with myopathy, though with different rates. Rosuvastatin is a potent statin reported to induce myopathy comparable to earlier statins. However, in clinical practice most patients could tolerate rosuvastatin over other statins. This study aimed to evaluate the myopathic pattern of rosuvastatin in rats using biochemical, functional and histopathological examinations. The possible deleterious effects of rosuvastatin on muscle mitochondria were also examined. The obtained results were compared to myopathy induced by atorvastatin in equimolar dose. Results showed that rosuvastatin induced a rise in CK, a slight increase in myoglobin level together with mild muscle necrosis. Motor activity, assessed by rotarod, showed that rosuvastatin decreased rats' performance. All these manifestations were obviously mild compared to the prominent effects of atorvastatin. Parallel results were obtained in mitochondrial dysfunction parameters. Rosuvastatin only induced a slight increase in LDH and a minor decrease in ATP (∼14%) and pAkt (∼12%). On the other hand, atorvastatin induced an increase in LDH, lactate/pyruvate ratio and a pronounced decline in ATP (∼80%) and pAkt (∼65%). These findings showed that rosuvastatin was associated with mild myotoxic effects in rats, especially when compared to atorvastatin. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective.

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Kones, Richard

2010-12-09

The major public health concern worldwide is coronary heart disease, with dyslipidemia as a major risk factor. Statin drugs are recommended by several guidelines for both primary and secondary prevention. Rosuvastatin has been widely accepted because of its efficacy, potency, and superior safety profile. Inflammation is involved in all phases of atherosclerosis, with the process beginning in early youth and advancing relentlessly for decades throughout life. C-reactive protein (CRP) is a well-studied, nonspecific marker of inflammation which may reflect general health risk. Considerable evidence suggests CRP is an independent predictor of future cardiovascular events, but direct involvement in atherosclerosis remains controversial. Rosuvastatin is a synthetic, hydrophilic statin with unique stereochemistry. A large proportion of patients achieve evidence-based lipid targets while using the drug, and it slows progression and induces regression of atherosclerotic coronary lesions. Rosuvastatin lowers CRP levels significantly. The Justification for Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial was designed after the observation that when both low density lipoprotein and CRP were reduced, patients fared better than when only LDL was lowered. Advocates and critics alike acknowledge that the benefits of rosuvastatin in JUPITER were real. After a review, the US Food and Drug Administration extended the indications for rosuvastatin to include asymptomatic JUPITER-eligible individuals with one additional risk factor. The American Heart Association and Centers of Disease Control and Prevention had previously recognized the use of CRP in persons with "intermediate risk" as defined by global risk scores. The Canadian Cardiovascular Society guidelines went further and recommended use of statins in persons with low LDL and high CRP levels at intermediate risk. The JUPITER study focused attention on ostensibly healthy individuals with

Resource costing for multinational neurologic clinical trials: methods and results.

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Schulman, K; Burke, J; Drummond, M; Davies, L; Carlsson, P; Gruger, J; Harris, A; Lucioni, C; Gisbert, R; Llana, T; Tom, E; Bloom, B; Willke, R; Glick, H

1998-11-01

We present the results of a multinational resource costing study for a prospective economic evaluation of a new medical technology for treatment of subarachnoid hemorrhage within a clinical trial. The study describes a framework for the collection and analysis of international resource cost data that can contribute to a consistent and accurate intercountry estimation of cost. Of the 15 countries that participated in the clinical trial, we collected cost information in the following seven: Australia, France, Germany, the UK, Italy, Spain, and Sweden. The collection of cost data in these countries was structured through the use of worksheets to provide accurate and efficient cost reporting. We converted total average costs to average variable costs and then aggregated the data to develop study unit costs. When unit costs were unavailable, we developed an index table, based on a market-basket approach, to estimate unit costs. To estimate the cost of a given procedure, the market-basket estimation process required that cost information be available for at least one country. When cost information was unavailable in all countries for a given procedure, we estimated costs using a method based on physician-work and practice-expense resource-based relative value units. Finally, we converted study unit costs to a common currency using purchasing power parity measures. Through this costing exercise we developed a set of unit costs for patient services and per diem hospital services. We conclude by discussing the implications of our costing exercise and suggest guidelines to facilitate more effective multinational costing exercises.

Clinical trial allocation in multinational pharmaceutical companies – a qualitative study on influential factors

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Dombernowsky, Tilde; Haedersdal, Merete; Lassen, Ulrik

2017-01-01

(1) to identify key decision makers during country and site selection, respectively, (2) to evaluate by which parameters subsidiaries are primarily assessed by headquarters with regard to conducting clinical trials, and (3) to evaluate which site-related qualities companies value most when selecting......Clinical trial allocation in multinational pharmaceutical companies includes country selection and site selection. With emphasis on site selection, the overall aim of this study was to examine which factors pharmaceutical companies value most when allocating clinical trials. The specific aims were...... trial sites. Eleven semistructured interviews were conducted among employees engaged in trial allocation at 11 pharmaceutical companies. The interviews were analyzed by deductive content analysis, which included coding of data to a categorization matrix containing categories of site-related qualities...

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

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Jung JA

2015-03-01

Full Text Available Jin Ah Jung,1 Soo-Yun Lee,2 Jung-Ryul Kim,1 Jae-Wook Ko,1,2 Seong Bok Jang,3 Su Youn Nam,3 Wooseong Huh1,41Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, 2Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, 3Yuhan Research Institute, Yuhan Corporation, 4Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaPurpose: Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects. Subjects and methods: Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day, valsartan (160 mg/day, and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study. Plasma concentrations of rosuvastatin, N-desmethyl rosuvastatin, and valsartan were determined using validated high-performance liquid chromatography with tandem mass spectrometry. Lipid profiles and vital signs (systolic and diastolic blood pressure and pulse rate were measured for the pharmacodynamic assessment.Results: For rosuvastatin, the geometric mean ratios (90% confidence intervals [CIs] of coadministration to mono-administration were 0.8809 (0.7873-0.9857 for maximum plasma concentration at steady state and 0.9151 (0.8632-0.9701 for area under the concentration–time curve (AUC over a dosing interval at steady state. For valsartan, the geometric mean ratios (90% CIs of those were 0.9300 (0.7946-1.0884 and 1.0072 (0.8893-1.1406, respectively. There were no significant differences in the metabolic ratio of N

Clinical utility of rosuvastatin and other statins for cardiovascular risk reduction among the elderly

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Sydney B Long

2010-12-01

Full Text Available Sydney B Long, Michael J Blaha, Roger S Blumenthal, Erin D MichosJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USAAbstract: Age is one of the strongest predictors of cardiovascular disease (CVD risk. Treatment with statins can significantly reduce CVD events and mortality in both primary and secondary prevention. Yet despite the high CVD risk among the elderly, there is underutilization of statins in this population (ie, the treatment-risk paradox. Few studies have investigated the use of statins in the elderly, particularly for primary prevention and, as a result, guidelines for treating the elderly are limited. This is likely due to: uncertainties of risk assessment in older individuals where the predictive value of individual risk factors is decreased; the need to balance the benefits of primary prevention with the risks of polypharmacy, health care costs, and adverse medication effects in a population with decreased life expectancy; the complexity of treating patients with many other comorbidities; and increasingly difficult social and economic concerns. As life expectancy increases and the total elderly population grows, these issues become increasingly important. JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin is the largest primary prevention statin trial to date and enrolled a substantial number of elderly adults. Among the 5695 JUPITER participants ≥70 years of age, the absolute CVD risk reduction associated with rosuvastatin was actually greater than for younger participants. The implications of this JUPITER subanalysis and the broader role of statins among older adults is the subject of this review.Keywords: JUPITER, rosuvastatin, elderly, risk

Managing hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin

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Wang Z

2013-12-01

Full Text Available Zhen Wang, Junbo GeDepartment of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of ChinaAbstract: Coronary heart disease (CHD is the leading cause of death worldwide. The efficacy and safety of statins in primary and secondary prevention of CHD is confirmed in several large studies, and rosuvastatin is the latest statin on market. We review the published literature on rosuvastatin in Chinese people. The pharmacokinetics of rosuvastatin in Chinese is somewhat different from that in Caucasians, but this does not influence the linear relationship between dosage and efficacy and with no drug accumulation. Rosuvastatin 5–20 mg/day is effective and safe in decreasing low-density lipoprotein cholesterol in both younger and elderly patients with hypercholesterolemia, even in very elderly patients. Rosuvastatin also shows anti-inflammatory and antiatherosclerosis features, such as reducing carotid intima-media thickness and plaque area. Rosuvastatin can also improve the prognosis of Chinese CHD patients, such as in the case of acute myocardial infarction. Its adverse-event rate is low and comparable to other statins. In conclusion, rosuvastatin is effective and safe for younger or elderly Chinese patients.Keywords: rosuvastatin, Chinese, younger, elderly

Possible effects of rosuvastatin on noise-induced oxidative stress in rat brain

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Alevtina Ersoy

2014-01-01

Full Text Available The problem of noise has recently gained more attention as it has become an integral part of our daily lives. However, its influence has yet to be fully elucidated. Other than being an unpleasant stimulus, noise may cause health disorders through annoyance and stress, including oxidative stress. Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, may possess antioxidant properties. Based on rat models, our project investigates the effect of rosuvastatin on noise-induced oxidative stress in the brain tissue. Thirty-two male Wistar albino rats were used. The rats were divided into four groups: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage, and control. After the data had been collected, oxidant and antioxidant parameters were analyzed in the cerebral cortex, brain stem, and cerebellum. Results indicated that superoxide dismutase values were significantly decreased in the cerebral cortex, while malondialdehyde values in the brainstem and cerebellum were significantly increased in the group with only noise exposure. Superoxide dismutase values in the brainstem were significantly increased, but nitric oxide values in the cerebellum and brainstem and malondialdehyde values in the cerebellum and cerebral cortex were significantly decreased in the group where only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased superoxide dismutase values in the cerebral cortex and brainstem, but significantly reduced malondialdehyde values in the brain stem. Consequently, our data show that brain tissue was affected by oxidative stress due to continued exposure to noise. This noise-induced stress decreases with rosuvastatin therapy.

Managing hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin.

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Wang, Zhen; Ge, Junbo

2014-01-01

Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of statins in primary and secondary prevention of CHD is confirmed in several large studies, and rosuvastatin is the latest statin on market. We review the published literature on rosuvastatin in Chinese people. The pharmacokinetics of rosuvastatin in Chinese is somewhat different from that in Caucasians, but this does not influence the linear relationship between dosage and efficacy and with no drug accumulation. Rosuvastatin 5-20 mg/day is effective and safe in decreasing low-density lipoprotein cholesterol in both younger and elderly patients with hypercholesterolemia, even in very elderly patients. Rosuvastatin also shows anti-inflammatory and anti-atherosclerosis features, such as reducing carotid intima-media thickness and plaque area. Rosuvastatin can also improve the prognosis of Chinese CHD patients, such as in the case of acute myocardial infarction. Its adverse-event rate is low and comparable to other statins. In conclusion, rosuvastatin is effective and safe for younger or elderly Chinese patients.

Effect of rosuvastatin on fasting and postprandial endothelial biomarker levels and microvascular reactivity in patients with type 2 diabetes and dyslipidemia: a preliminary report.

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Kim, Kyoung Min; Jung, Kyong Yeun; Yun, Han Mi; Lee, Seo Young; Oh, Tae Jung; Jang, Hak Chul; Lim, Soo

2017-11-09

�weeks improved microvascular reactivity with concomitant beneficial changes in the postprandial levels of PON-1 and ADMA. These results suggest that rosuvastatin improves the postprandial cardiometabolic milieu in type 2 diabetes. Trial registration ClinicalTrials.gov: NCT02185963 (July 7, 2014).

Rosuvastatin and atorvastatin: comparative effects on glucose metabolism in non-diabetic patients with dyslipidaemia.

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Abbas, Ahmed; Milles, John; Ramachandran, Sudarshan

2012-01-01

The ever increasing interventional CVD outcome studies have resulted in statins being an essential factor of cardiovascular prevention strategies. The JUPITER study in 2008, despite reducing CVD and overall mortality, highlighted an increase in new onset diabetes in the rosuvastatin treated arm. Since then there have been many meta-analyses of the RCTs and the largest carried out by Sattar et al showed a significant increase in the incidence of diabetes during the trials. The findings from the individual studies when comparing the different statins were less clear. A higher statin dosage and risk factors associated with diabetes appeared to predict this phenomenon. There have been many studies investigating the effects of statins on glycaemic control, but again no clear conclusion is apparent. Despite the increase in new onset diabetes observed, the risk is clearly out-weighed by the CVD benefits observed in nearly all the statin trials. Thus, no change is required to any of the prevention guidelines regarding statins. However, it may be prudent to monitor glycaemic control after commencing statin therapy. This review will focus on atorvastatin which is the most widely used statin worldwide and rosuvastatin which is the most efficacious. This will be against a background of the effects of other statins on glucose metabolism in non-diabetic patients.

Is rosuvastatin protective against on noise-induced oxidative stress in rat serum?

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Emine Rabia Koc

2015-01-01

Full Text Available Noise, one of the main components of modern society, has become an important environmental problem. Noise is not only an irritating sound, but also a stress factor leading to serious health problems. In this study, we have investigated possible effects of rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, thought to have an antioxidant effect, on noise-induced oxidative stress in the serum of rat models. Thirty-two male Wistar albino rats were used. In order to ease their adaptation, 2 weeks before the experiment, the rats were divided into four groups (with eight rats per each group: Noise exposure plus rosuvastatin usage, only noise exposure, only rosuvastatin usage and control. After the data had been collected, oxidant (Malondialdehyde, nitric oxide [NO], protein carbonyl [PC] and antioxidant (superoxide dismutase [SOD], glutathione peroxidase [GSH-PX], catalase [CAT] parameters were analyzed in the serum. Results indicated that SOD values were found to be significantly lower, while PC values in serum were remarkably higher in the group that was exposed to only noise. GSH-Px values in serum dramatically increased in the group on which only rosuvastatin was used. During noise exposure, the use of rosuvastatin caused significantly increased CAT values, whereas it resulted in reduced PC and NO values in serum. In conclusion, our data show that noise exposure leads to oxidative stress in rat serum; however, rosuvastatin therapy decreases the oxidative stress caused by noise exposure.

Rosuvastatin-Induced Carotid Plaque Regression in Patients With Inflammatory Joint Diseases: The Rosuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and Other Inflammatory Joint Diseases Study.

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Rollefstad, S; Ikdahl, E; Hisdal, J; Olsen, I C; Holme, I; Hammer, H B; Smerud, K T; Kitas, G D; Pedersen, T R; Kvien, T K; Semb, A G

2015-07-01

Patients with rheumatoid arthritis (RA) and carotid artery plaques have an increased risk of acute coronary syndromes. Statin treatment with the goal of achieving a low-density lipoprotein (LDL) cholesterol level of ≤1.8 mmoles/liter (≤70 mg/dl) is recommended for individuals in the general population who have carotid plaques. The aim of the ROsuvastatin in Rheumatoid Arthritis, Ankylosing Spondylitis and other inflammatory joint diseases (RORA-AS) study was to evaluate the effect of 18 months of intensive lipid-lowering treatment with rosuvastatin with regard to change in carotid plaque height. Eighty-six patients (60.5% of whom were female) with carotid plaques and inflammatory joint disease (55 with RA, 21 with AS, and 10 with psoriatic arthritis) were treated with rosuvastatin to obtain the LDL cholesterol goal. Carotid plaque height was evaluated by B-mode ultrasonography. The mean ± SD age of the patients was 60.8 ± 8.5 years, and the median compliance with rosuvastatin treatment was 97.9% (interquartile range [IQR] 96.0-99.4). At baseline, the median number and height of the carotid plaques were 1.0 (range 1-8) and 1.80 mm (IQR 1.60-2.10), respectively. The mean ± SD change in carotid plaque height after 18 months of treatment with rosuvastatin was -0.19 ± 0.35 mm (P < 0.0001). The mean ± SD baseline LDL cholesterol level was 4.0 ± 0.9 mmoles/liter (154.7 ± 34.8 mg/dl), and the mean reduction in the LDL cholesterol level was -2.3 mmoles/liter (95% confidence interval [95% CI] -2.48, -2.15) (-88.9 mg/dl [95% CI -95.9, -83.1]). The mean ± SD LDL cholesterol level during the 18 months of rosuvastatin treatment was 1.7 ± 0.4 mmoles/liter (area under the curve). After adjustment for age/sex/blood pressure, no linear relationship between a reduction in carotid plaque height and the level of LDL cholesterol exposure during the study period was observed. Attainment of the LDL cholesterol goal of ≤1.8 mmoles/liter (≤70

Rosuvastatin and Atorvastatin: Comparative Effects on Glucose Metabolism in Non-Diabetic Patients with Dyslipidaemia

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Ahmed Abbas

2012-01-01

Full Text Available The ever increasing interventional CVD outcome studies have resulted in statins being an essential factor of cardiovascular prevention strategies. The JUPITER study in 2008, despite reducing CVD and overall mortality, highlighted an increase in new onset diabetes in the rosuvastatin treated arm. Since then there have been many meta-analyses of the RCTs and the largest carried out by Sattar et al showed a significant increase in the incidence of diabetes during the trials. The findings from the individual studies when comparing the different statins were less clear. A higher statin dosage and risk factors associated with diabetes appeared to predict this phenomenon. There have been many studies investigating the effects of statins on glycaemic control, but again no clear conclusion is apparent. Despite the increase in new onset diabetes observed, the risk is clearly out-weighed by the CVD benefits observed in nearly all the statin trials. Thus, no change is required to any of the prevention guidelines regarding statins. However, it may be prudent to monitor glycaemic control after commencing statin therapy. This review will focus on atorvastatin which is the most widely used statin worldwide and rosuvastatin which is the most efficacious. This will be against a background of the effects of other statins on glucose metabolism in non-diabetic patients.

Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study.

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Ashton, Emma; Windebank, Emma; Skiba, Marina; Reid, Christopher; Schneider, Hans; Rosenfeldt, Franklin; Tonkin, Andrew; Krum, Henry

2011-02-03

Statins are often prescribed for prevention of atherosclerotic outcomes in patients who have chronic heart failure (CHF), if this has an ischaemic etiology. These agents may also possess additional properties, independent of effects on blood lipid levels, which may have an effect on cardiac remodeling. However, beneficial effects were not observed in the recent UNIVERSE trial. We prospectively planned a sub-study of UNIVERSE to explore relevant mechanistic effects of rosuvastatin, including effects on collagen turnover and plasma coenzyme Q10 (CoQ) levels. Additionally, CoQ levels in CHF patients receiving chronic statin therapy were measured. CoQ levels were significantly reduced after 26 weeks of rosuvastatin statin therapy (n = 32), compared to placebo (n = 37) in CHF patients in UNIVERSE trial. Patients with CHF (n = 56) matched for age, gender and severity of disease who had been taking statins for 12 months or longer had CoQ levels of 847 ± 344 nmol/L, significantly lower than 1065.4 ± 394 nmol/L in UNIVERSE patients at baseline (p = 0.0001). Serum types I and III N-terminal procollagen peptide (PINP and PIIINP), measures of collagen turnover which can contribute to cardiac fibrosis were significantly increased in the rosuvastatin group compared to baseline in UNIVERSE patients (PINP: p = 0.03, PIIINP: p = 0.001). In conclusion putative beneficial effects of statin therapy on cardiac remodeling in UNIVERSE may have been negated by increases in collagen turnover markers as well as a reduction in plasma CoQ levels in these patients with CHF. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

Ascorbic acid supplementation partially prevents the delayed reproductive development in juvenile male rats exposed to rosuvastatin since prepuberty.

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Leite, Gabriel Adan Araújo; Figueiredo, Thamiris Moreira; Sanabria, Marciana; Dias, Ana Flávia Mota Gonçalves; Silva, Patrícia Villela E; Martins Junior, Airton da Cunha; Barbosa Junior, Fernando; Kempinas, Wilma De Grava

2017-10-01

Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. This study aimed to evaluate whether ascorbic acid supplementation may prevent the reproductive damage provoked by rosuvastatin administration at prepuberty. Male pups were distributed into six experimental groups that received saline solution 0.9%, 3 or 10mg/kg/day of rosuvastatin, 150mg/day of ascorbic acid, or 150mg/day of ascorbic acid associated with 3 or 10mg/kg/day of rosuvastatin from post-natal day (PND) 23 until PND53. Rosuvastatin-treated groups showed delayed puberty installation, androgen depletion and impairment on testicular and epididymal morphology. Ascorbic acid partially prevented these reproductive damages. In conclusion, rosuvastatin exposure is a probable risk to reproductive development and ascorbic acid supplementation may be useful to prevent the reproductive impairment of rosuvastatin exposure. Copyright © 2017 Elsevier Inc. All rights reserved.

A network meta-analysis on randomized trials focusing on the preventive effect of statins on contrast-induced nephropathy

DEFF Research Database (Denmark)

Peruzzi, Mariangela; De Luca, Leonardo; Thomsen, Henrik S

2014-01-01

-analysis. Randomized trials focusing on statins were searched and pooled with random-effect odds ratios. A total of 14 trials (6,160 patients) were included, focusing on atorvastatin (high/low dose), rosuvastatin (high dose), simvastatin (high/low dose), and placebo or no statin therapy before contrast administration....... The risk of contrast-induced nephropathy was reduced by atorvastatin high dose and rosuvastatin high dose, with no difference between these two agents. Results for atorvastatin low dose and simvastatin (high/low dose) in comparison to placebo were inconclusive. Atorvastatin and rosuvastatin administered...

Rosuvastatin Decreases Intestinal Fatty Acid Binding Protein (I-FABP), but Does Not Alter Zonulin or Lipopolysaccharide Binding Protein (LBP) Levels, in HIV-Infected Subjects on Antiretroviral Therapy.

Science.gov (United States)

Funderburg, Nicholas T; Boucher, Morgan; Sattar, Abdus; Kulkarni, Manjusha; Labbato, Danielle; Kinley, Bruce I; McComsey, Grace A

2016-01-01

Altered gastrointestinal (GI) barrier integrity and subsequent microbial translocation may contribute to immune activation in HIV infection. We have reported that rosuvastatin improved several markers of immune activation in HIV+ participants, but the effect of statin treatment on markers of GI barrier dysfunction is unknown. SATURN-HIV is a randomized, double-blind, placebo-controlled trial assessing the effect of rosuvastatin (10mg/daily) on markers of cardiovascular disease, inflammation, and immune activation in ART-treated patients. Gut-barrier integrity was assessed by the surrogate markers intestinal fatty acid binding protein (I-FABP), a marker of enterocyte death, and zonulin-1, a marker of gut epithelial cell function. Levels of lipopolysaccharide binding protein (LBP) were measured as a marker of microbial translocation. Rosuvastatin significantly reduced levels of I-FABP during the treatment period compared to the placebo. There was no effect of rosuvastatin treatment on levels of zonulin or LBP. Baseline levels of LBP were directly related to several markers of immune activation in samples from all participants, including soluble CD163, IP-10, VCAM-1, TNFR-II, and the proportion of CD4+ and CD8+ T cells expressing CD38 and HLA-DR. Many of these relationships, however, were not seen in the statin arm alone at baseline or over time, as inflammatory markers often decreased and LBP levels were unchanged. Forty-eight weeks of rosuvastatin treatment reduced levels of I-FABP, but did not affect levels of zonulin or LBP. The reduction in levels of inflammatory markers that we have reported with rosuvastatin treatment is likely mediated through other mechanisms not related to gut integrity or microbial translocation.

Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.

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Bergman, Ebba; Lundahl, Anna; Fridblom, Patrik; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars; Lennernäs, Hans

2009-12-01

The hepatobiliary transport and local disposition of rosuvastatin in pig were investigated, along with the impact of concomitant dosing with two known multiple transport inhibitors; cyclosporine and gemfibrozil. Rosuvastatin (80 mg) was administered as an intrajejunal bolus dose in treatments I, II, and III (TI, TII, and TIII, respectively; n = 6 per treatment). Cyclosporine (300 mg) and gemfibrozil (600 mg) were administered in addition to the rosuvastatin dose in TII and TIII, respectively. Cyclosporine was administered as a 2-h intravenous infusion and gemfibrozil as an intrajejunal bolus dose. In treatment IV (TIV, n = 4) 5.9 mg of rosuvastatin was administered as an intravenous bolus dose. The study was conducted using a pig model, which enabled plasma sampling from the portal (VP), hepatic (VH), and femoral veins and bile from the common hepatic duct. The biliary recoveries of the administered rosuvastatin dose were 9.0 +/- 3.5 and 35.7 +/- 15.6% in TI and TIV, respectively. Rosuvastatin was highly transported into bile as shown by the median AUC(bile)/AUC(VH) ratio in TI of 1770 (1640-11,300). Gemfibrozil did not have an effect on the plasma pharmacokinetics of rosuvastatin, most likely because the unbound inhibitor concentrations did not exceed the reported IC(50) values. However, cyclosporine significantly reduced the hepatic extraction of rosuvastatin (TI, 0.89 +/- 0.06; TII, 0.46 +/- 0.13) and increased the AUC(VP) and AUC(VH) by 1.6- and 9.1-fold, respectively. In addition, the biliary exposure and f(e, bile) were reduced by approximately 50%. The strong effect of cyclosporine was in accordance with inhibition of sinusoidal uptake transporters, such as members of the organic anion-transporting polypeptide family, rather than canalicular transporters.

Effect of rosuvastatin monotherapy and in combination with fenofibrate or omega-3 fatty acids on serum vitamin D levels.

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Makariou, Stefania E; Liberopoulos, Evangelos N; Agouridis, Aris P; Challa, Anna; Elisaf, Moses

2012-12-01

Low levels of 25(OH) vitamin D [25(OH)VitD] have been recognized as a new cardiovascular disease (CVD) risk factor. Statins seem to increase 25(OH)VitD concentration. To investigate whether combined treatment with the usual dose of rosuvastatin plus fenofibrate or omega-3 fatty acids would increase 25(OH)VitD levels compared with the high-dose rosuvastatin monotherapy in participants with mixed dislipidemia. We randomly allocated 60 patients with mixed dyslipidemia (low-density lipoprotein cholesterol: >160 mg/dL plus triglycerides: >200 mg/dL) to receive rosuvastatin 40 mg (n = 22), rosuvastatin 10 mg plus fenofibrate 200 mg (n = 21), or rosuvastatin 10 mg plus omega-3 fatty acids 2 g (n = 17) daily for 3 months. Our primary end point was changes in the levels of serum 25(OH)VitD. Rosuvastatin monotherapy was associated with a 53% increase in 25(OH)VitD (from 14.6 [1.0-38.0] to 17.8 [5.3-49.6] ng/mL; P = .000). Rosuvastatin plus micronized fenofibrate and rosuvastatin plus omega-3 fatty acids were associated with increases of 64% (from 14.1 [1.0-48.0] to 18.4 [6.7-52.4] ng/mL, P = .001) and 61% (from 10.4 [6.6-38.4] to 14.0 [9.6-37.6] ng/mL, P = .04), respectively. The changes in 25(OH)VitD after treatment were comparable in the 3 groups. High-dose rosuvastatin monotherapy and the usual dose of rosuvastatin plus fenofibrate or omega-3 fatty acids are associated with significant and similar increases in the 25(OH)VitD levels. This increase may be relevant in terms of CVD risk prevention.

Rosuvastatin reduces neointima formation in a rat model of balloon injury

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Preusch MR

2010-11-01

Full Text Available Abstract Background Processes of restenosis, following arterial injury, are complex involving different cell types producing various cytokines and enzymes. Among those enzymes, smooth muscle cell-derived matrix metalloproteinases (MMPs are thought to take part in cell migration, degrading of extracellular matrix, and neointima formation. MMP-9, also known as gelatinase B, is expressed immediately after vascular injury and its expression and activity can be inhibited by statins. Using an established in vivo model of vascular injury, we investigated the effect of the HMG-CoA reductase inhibitor rosuvastatin on MMP-9 expression and neointima formation. Materials and methods 14-week old male Sprague Dawley rats underwent balloon injury of the common carotid artery. Half of the animals received rosuvastatin (20 mg/kg body weight/day via oral gavage, beginning 3 days prior to injury. Gelatinase activity and neointima formation were analyzed 3 days and 14 days after balloon injury, respectively. 14 days after vascular injury, proliferative activity was assessed by staining for Ki67. Results After 14 days, animals in the rosuvastatin group showed a decrease in total neointima formation (0.194 ± 0.01 mm2 versus 0.124 ± 0.02 mm2, p Conclusions Rosuvastatin attenuates neointima formation without affecting early MMP-9 activity in a rat model of vascular injury.

Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study

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Berne Christian

2005-06-01

Full Text Available Abstract Objective The Use of Rosuvastatin versus Atorvastatin iN type 2 diabetes mellitUS (URANUS study compared rosuvastatin with atorvastatin for the reduction of low-density lipoprotein cholesterol (LDL-C in patients with type 2 diabetes. Methods After a 6-week dietary run-in, patients aged ≥ 18 years with type 2 diabetes and LDL-C ≥ 3.3 mmol/L were randomised to double-blind treatment with rosuvastatin 10 mg (n = 232 or atorvastatin 10 mg (n = 233 for 4 weeks. Doses were then titrated up to a maximum of rosuvastatin 40 mg or atorvastatin 80 mg over 12 weeks to achieve the 1998 European LDL-C goal ( Results Rosuvastatin reduced LDL-C levels significantly more than atorvastatin during the fixed-dose and titration periods (p Conclusion At the start dose and following dose titration, rosuvastatin was significantly more effective than atorvastatin at reducing LDL-C and achieving European LDL-C goals in patients with type 2 diabetes.

Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice.

Science.gov (United States)

Schroeter, Marco R; Humboldt, Tim; Schäfer, Katrin; Konstantinides, Stavros

2009-07-01

Statins enhance incorporation of bone marrow-derived cells into experimental neointimal lesions. However, the contribution of progenitor cells to progression of spontaneous atherosclerotic plaques, and the possible modulatory role of statins in this process, remain poorly understood. We compared the effects of rosuvastatin (1 and 10mg/kg BW) and pravastatin (10mg/kg) on progenitor cell mobilisation, recruitment into atherosclerotic plaques, and lesion growth. Statins were administered over 8 weeks to apolipoprotein E knockout mice on atherogenic diet. In addition, mice were lethally irradiated, followed by transplantation of bone marrow from LacZ transgenic mice. Rosuvastatin reduced lesion area and intima-to-media ratio at the brachiocephalic artery compared to vehicle, while both parameters were not significantly altered by pravastatin. Rosuvastatin also augmented endothelialisation (P<0.05) and reduced the smooth muscle cells (SMC) content (P=0.042) of lesions. Numbers of c-kit, sca-1 and flk-1, sca-1 double-positive progenitor cells were significantly increased in rosuvastatin compared to control-treated mice, both in the bone marrow and the peripheral blood. Similarly, the number of spleen-derived acLDL, lectin double-positive progenitor cells (P=0.001) and colony-forming units (P=0.0104) was significantly increased in mice treated with rosuvastatin compared to vehicle alone. In the bone marrow, increased Akt and p42/44 MAP kinase phosphorylation and upregulated SDF1alpha mRNA expression were observed. Importantly, rosuvastatin treatment also increased the plasma levels of c-kit ligand (P=0.003), and the number of c-kit-positive cells within atherosclerotic lesions (P=0.041). Our findings suggest that rosuvastatin reduces the size of atherosclerotic plaques, and this effect appears to involve progenitor cell mobilisation and recruitment into vascular lesions.

Safety and vasopressor effect of rosuvastatin in septic patients

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Hanaa A. El Gendy

2014-07-01

Conclusions: Rosuvastatin 20 mg/day in septic patients increased number ABPSPD, decreased time to initial ABPSPD, norepinephrine dose and duration, with no significant elevation in transaminases or CPK.

Effects of maximal doses of atorvastatin versus rosuvastatin on small dense low-density lipoprotein cholesterol levels

Science.gov (United States)

Maximal doses of atorvastatin and rosuvastatin are highly effective in lowering low-density lipoprotein (LDL) cholesterol and triglyceride levels; however, rosuvastatin has been shown to be significantly more effective than atorvastatin in lowering LDL cholesterol and in increasing high-density lipo...

Standard requirements for GCP-compliant data management in multinational clinical trials

LENUS (Irish Health Repository)

Ohmann, Christian

2011-03-22

Abstract Background A recent survey has shown that data management in clinical trials performed by academic trial units still faces many difficulties (e.g. heterogeneity of software products, deficits in quality management, limited human and financial resources and the complexity of running a local computer centre). Unfortunately, no specific, practical and open standard for both GCP-compliant data management and the underlying IT-infrastructure is available to improve the situation. For that reason the "Working Group on Data Centres" of the European Clinical Research Infrastructures Network (ECRIN) has developed a standard specifying the requirements for high quality GCP-compliant data management in multinational clinical trials. Methods International, European and national regulations and guidelines relevant to GCP, data security and IT infrastructures, as well as ECRIN documents produced previously, were evaluated to provide a starting point for the development of standard requirements. The requirements were produced by expert consensus of the ECRIN Working group on Data Centres, using a structured and standardised process. The requirements were divided into two main parts: an IT part covering standards for the underlying IT infrastructure and computer systems in general, and a Data Management (DM) part covering requirements for data management applications in clinical trials. Results The standard developed includes 115 IT requirements, split into 15 separate sections, 107 DM requirements (in 12 sections) and 13 other requirements (2 sections). Sections IT01 to IT05 deal with the basic IT infrastructure while IT06 and IT07 cover validation and local software development. IT08 to IT015 concern the aspects of IT systems that directly support clinical trial management. Sections DM01 to DM03 cover the implementation of a specific clinical data management application, i.e. for a specific trial, whilst DM04 to DM12 address the data management of trials across the unit

A taxonomy of multinational ethical and methodological standards for clinical trials of therapeutic interventions

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Ashton, Carol M; Wray, Nelda P; Jarman, Anna F; Kolman, Jacob M; Wenner, Danielle M; Brody, Baruch A

2013-01-01

Background If trials of therapeutic interventions are to serve society’s interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical-trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world’s nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample (N=55) of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial’s stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. PMID:21429960

Effects of intensive atorvastatin and rosuvastatin treatment on apolipoprotein B-48 and remnant lipoprotein cholesterol levels

Science.gov (United States)

Atorvastatin and rosuvastatin at maximal doses are both highly effective in lowering low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels. Rosuvastatin has been shown to be more effective than atorvastatin in lowering LDL-C, small dense LDL-C and in raising high-density lipoprote...

Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations

DEFF Research Database (Denmark)

Stein, Evan A; Dann, Eldad J; Wiegman, Albert

2017-01-01

formally evaluated in, or approved for, HoFH children. OBJECTIVES: The authors sought to assess the LDL-C efficacy of rosuvastatin versus placebo in HoFH children, and the relationship with underlying genetic mutations. METHODS: This was a randomized, double-blind, 12-week, crossover study of rosuvastatin...... 20 mg versus placebo, followed by 12 weeks of open-label rosuvastatin. Patients discontinued all lipid-lowering treatment except ezetimibe and/or apheresis. Clinical and laboratory assessments were performed every 6 weeks. The relationship between LDL-C response and genetic mutations was assessed....../dl (range: 130 to 700 mg/dl) on rosuvastatin, producing a mean 85.4 mg/dl (22.3%) difference (p = 0.005). Efficacy was similar regardless of age or use of ezetimibe or apheresis, and was maintained for 12 weeks. Adverse events were few and not serious. Patients with 2 defective versus 2 negative LDL...

Efficacy and safety of rosuvastatin every other day compared with once daily in patients with hypercholesterolemia.

Science.gov (United States)

Wongwiwatthananukit, Supakit; Sansanayudh, Nakarin; Dhummauppakorn, Rawadee; Kitiyadisai, Chutiporn

2006-11-01

Although most patients with hypercholesterolemia require life-long therapy with statins, these drugs are underused due to high costs. Every-other-day therapy could be one strategy to resolve this problem. To compare the efficacy and safety of rosuvastatin 10 mg administered every other day versus once daily. An 8 week, randomized, open-label, parallel trial was conducted at the outpatient department of Phramongkutklao Hospital in Bangkok, Thailand. Eighty patients with primary hypercholesterolemia were equally randomized to receive rosuvastatin 10 mg once daily or every other day; 76 patients completed the study. Laboratory data were assessed at baseline and at the end of the study. Low-density lipoprotein cholesterol (LDL-C) levels were reduced by 48% and 39% in the once-daily and every-other-day groups, respectively (p = 0.011). The percentage of patients who achieved LDL-C goals according to National Cholesterol Education Program-Adult Treatment Panel III guidelines was not significantly different between the once-daily (85%) and every-other-day (70%) groups (p = 0.180). In addition, both regimens were well tolerated, with no patient developing an elevation of more than 3 times baseline levels of aspartate aminotransferase or alanine aminotransferase or 10 times that of creatine kinase. As expected, the monthly cost per percent LDL-C reduction of the once-daily (0.72 dollars) regimen was about 38% higher than that of the every-other-day (0.44 dollars) regimen. Every-other-day dosing of rosuvastatin may be an alternative regimen for cost savings, without a major decrease in therapeutic benefit or increase in adverse events, in patients with hypercholesterolemia. The number of patients achieving their LDL-C goal using the every-other-day regimen is comparable with the number using the once-daily regimen, especially in the low-risk patient category.

[Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue].

Science.gov (United States)

Valero-Muñoz, María; Martín-Fernández, Beatriz; Ballesteros, Sandra; Cachofeiro, Victoria; Lahera, Vicente; de Las Heras, Natalia

2014-01-01

To study the effects of rosuvastatin on insulin resistance in overweight rats induced by high fat diet, as well as potential mediators. We used male Wistar rats fed with a standard diet (CT) or high fat diet (33.5% fat) (HFD); half of the animals HFD were treated with rosuvastatin (15mg/kg/day) (HFD+Rosu) for 7 weeks. HFD rats showed increased body, epididymal and lumbar adipose tissue weights. Treatment with Rosu did not modify body weight or the weight of the adipose packages in HFD rat. Plasma glucose and insulin levels and HOMA index were higher in HFD rats, and rosuvastatin treatment reduced them. Leptin/adiponectin ratio in plasma and lumbar adipose tissue were higher in HDF rats, and were reduced by rosuvastatin. SIRT-1, PPAR-γ and GLUT-4 protein expression in lumbar adipose tissue were lower in HFD rats and Rosu normalized expression of the three mediators. Rosuvastatin ameliorates insulin sensitivity induced by HFD in rats. This effect is mediated by several mechanisms including reduction of leptin and enhancement of SIRT-1, PPAR-γ and GLUT-4 expression in white adipose tissue. SIRT1 could be considered a major mediator of the beneficial effects of rosuvastatin on insulin sensitivity in overweight rats induced by diet. Copyright © 2013 Sociedad Española de Arteriosclerosis. Published by Elsevier España. All rights reserved.

Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.

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Kulmatycki, Kenneth; Hanna, Imad; Meyers, Dan; Salunke, Atish; Movva, Aishwarya; Majumdar, Tapan; Natrillo, Adrienne; Vapurcuyan, Arpine; Rebello, Sam; Sunkara, Gangadhar; Chen, Jin

2015-05-01

An in vitro drugdrug interaction (DDI) study was performed to assess the potential for pradigastat to inhibit breast cancer resistance protein (BCRP), organic anion-transporting polypeptide (OATP), and organic anion transporter 3 (OAT3) transport activities. To understand the relevance of these in vitro findings, a clinical pharmacokinetic DDI study using rosuvastatin as a BCRP, OATP, and OAT3 probe substrate was conducted. The study used cell lines that stably expressed or over-expressed the respective transporters. The clinical study was an open-label, single sequence study where subjects (n = 36) received pradigastat (100 mg once daily x 3 days thereafter 40 mg once daily) and rosuvastatin (10 mg once daily), alone and in combination. Pradigastat inhibited BCRP-mediated efflux activity in a dose-dependent fashion in a BCRP over-expressing human ovarian cancer cell line with an IC(50) value of 5 μM. Similarly, pradigastat inhibited OATP1B1, OATP1B3 (estradiol 17β glucuronide transport), and OAT3 (estrone 3 sulfate transport) activity in a concentrationdependent manner with estimated IC(50) values of 1.66 ± 0.95 μM, 3.34 ± 0.64 μM, and 0.973 ± 0.11 μM, respectively. In the presence of steady state pradigastat concentrations, AUC(τ, ss) of rosuvastatin was unchanged and its Cmax,ss decreased by 14% (5.30 and 4.61 ng/mL when administered alone and coadministered with pradigastat, respectively). Pradigastat AUC(τ, ss) and C(max, ss) were unchanged when coadministered with rosuvastatin at steady state. Both rosuvastatin and pradigastat were well tolerated. These data indicate no clinically relevant pharmacokinetic interaction between pradigastat and rosuvastatin.

Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high-risk patients with hypercholesterolemia – Prospective study to evaluate the Use of Low doses of the Statins Atorvastatin and Rosuvastatin (PULSAR

Directory of Open Access Journals (Sweden)

García Hugo

2006-12-01

Full Text Available Abstract Background Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg and atorvastatin (20 mg in high-risk patients with hypercholesterolemia. Methods A total of 996 patients with hypercholesterolemia (LDL-C ≥ 3.4 and Results Rosuvastatin 10 mg reduced LDL-C levels significantly more than atorvastatin 20 mg at week 6 (44.6% vs. 42.7%, p Conclusion In high-risk patients with hypercholesterolemia, rosuvastatin 10 mg was more efficacious than atorvastatin 20 mg at reducing LDL-C, enabling LDL-C goal achievement and improving other lipid parameters. Both treatments were well tolerated.

Effects of atorvastatin and rosuvastatin on blood lipids, platelet ...

African Journals Online (AJOL)

Conclusion: Atorvastatin and rosuvastatin have no significant effect on the antiplatelet .... J20120006; Astra Zeneca UK limited) 10 mg, .... by Johansen et al [29] and Wang et al [30] .... Pan Y, Chen W, Xu Y, Yi X, Han Y, Yang Q, Li X, Huang.

Plasma Drug Concentrations of Orally Administered Rosuvastatin in Hispaniolan Amazon Parrots (Amazona ventralis).

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Beaufrère, Hugues; Papich, Mark G; Brandão, João; Nevarez, Javier; Tully, Thomas N

2015-03-01

Atherosclerotic diseases are common in pet psittacine birds, in particular Amazon parrots. While hypercholesterolemia and dyslipidemia have not definitely been associated with increased susceptibility to atherosclerosis in parrots, these are important and well-known risk factors in humans. Therefore statin drugs such as rosuvastatin constitute the mainstay of human treatment of dyslipidemia and the prevention of atherosclerosis. No pharmacologic studies have been performed in psittacine birds despite the high prevalence of atherosclerosis in captivity. Thirteen Hispaniolan Amazon parrots were used to test a single oral dose of 10 mg/kg of rosuvastatin with blood sampling performed according to a balanced incomplete block design over 36 hours. Because low plasma concentrations were produced in the first study, a subsequent pilot study using a dose of 25 mg/kg in 2 Amazon parrots was performed. Most plasma samples for the 10 mg/kg dose and all samples for the 25 mg/kg dose had rosuvastatin concentration below the limits of quantitation. For the 10 mg/kg study, the median peak plasma concentration and time to peak plasma concentration were 0.032 μg/mL and 2 hours, respectively. Our results indicate that rosuvastatin does not appear suitable in Amazon parrots as compounded and used at the dose in this study. Pharmacodynamic studies investigating lipid-lowering effects of statins rather than pharmacokinetic studies may be more practical and cost effective in future studies to screen for a statin with more ideal properties for potential use in psittacine dyslipidemia and atherosclerotic diseases.

Horizontal Multinational Firms, Vertical Multinational Firms and Domestic Investment

NARCIS (Netherlands)

J. Emami Namini (Julian); H.P.G. Pennings (Enrico)

2009-01-01

textabstractWe build a dynamic general equilibrium model with 2 countries, horizontal and vertical multinational activity and endogenous domestic and foreign investment. It is found that horizontal multinational activity always leads to a complementary relationship between domestic and foreign

Comparisons of hypertension-related costs from multinational clinical studies.

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Mullins, C Daniel; Sikirica, Mirko; Seneviratne, Viran; Ahn, Jeonghoon; Akhras, Kasem S

2004-01-01

This study identifies and compares the individual cost components of hospital and ambulatory services that manage the care of hypertensive patients in eight countries: the US, the UK, France, Spain, Germany, Italy, Canada and Australia. Hypertension-related costs are classified according to four major cardiovascular events: (i) acute myocardial infarction; (ii) congestive heart failure; (iii) stroke; and (iv) renal failure, which was subdivided into renal failure treated by dialysis and renal failure treated by kidney transplantation. To make cross-country costs comparisons, we used the DRG codes used in the US and DRG-like codes from each country. US cost information was obtained from hypertension data available from the literature and health economics researchers. For costs in other countries, we consulted with national health economics experts in each country, used analyses by the Research Triangle Institute, and performed Medline and international literature searches. When available, we obtained information from the countries' public and private nationally representative data sources. For cross-country currency adjustments, all currencies were converted using the Purchasing Power Parities from the Organisation for Economic Cooperation and Development, and then converted into inflation-adjusted year 2000 US dollars. There exists considerable variation in hypertension-related costs from multinational clinical studies. This study documents that costs are generally higher in the US than in other countries; however, this is not always true. In particular, costs of treating heart failure in France and the costs of renal failure without transplantation in Germany and the UK are relatively high. While analysing multinational hypertensive cost data, this study also addresses the impact of cross-country cost variations on cost analyses. During the last decade, drug-development researchers have drawn extensively upon multinational trials to resolve enrollment problems and

Cost-Effectiveness Analysis of Atorvastatin versus Rosuvastatin in Primary and Secondary Cardiovascular Prevention Populations in Brazil and Columbia.

Science.gov (United States)

Mould-Quevedo, Joaquín F; Gutiérrez-Ardila, Magda Vianey; Ordóñez Molina, Jaime Eduardo; Pinsky, Brett; Vargas Zea, Nicolás

2014-12-01

Latin America has witnessed a marked increase in cardiovascular (CV) disease, the leading cause of death in many countries. The benefits of lipid-lowering therapy to reduce CV-related events are widely accepted. Clinical evidence suggests that rosuvastatin is associated with slightly greater reductions in low-density lipoprotein cholesterol levels than is atorvastatin at comparable doses. Rosuvastatin, however, is often priced at a premium. Our objective was to examine the cost-effectiveness of using atorvastatin versus rosuvastatin in reducing CV events in Brazil and Colombia using real-world prices. A global Markov cohort model of primary and secondary CV prevention was developed and adapted to Brazilian and Colombian settings. The risks and costs of major CV events and efficacy, adherence, and costs of statins were considered. Total gains in life-years, quality-adjusted life-years, major CV events avoided, and costs over the lifetime horizon were estimated. Several dose comparisons were considered. In the Colombian analyses, differences in drug costs between therapies were considerable while outcomes were similar. The incremental cost per quality-adjusted life-year gained for rosuvastatin versus atorvastatin was more than $700,000 and $200,000 in primary and secondary prevention, respectively. Brazilian analyses found lower incremental cost-effectiveness ratios for rosuvastatin at some dose comparisons due to similar pricing between statins. Sensitivity analyses revealed that changes in treatment efficacy and adherence had the largest impact on results. In primary and secondary CV prevention, the efficacy advantage of rosuvastatin was minimal, while its acquisition cost was higher, particularly in Colombia. The incremental cost-effectiveness ratios were, therefore, generally in favor of atorvastatin being the cost-effective option. Copyright © 2014 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights

Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein

NARCIS (Netherlands)

Ridker, Paul M.; Fonseca, Francisco A. H.; Genest, Jacques; Gotto, Antonio M.; Kastelein, John J. P.; Khurmi, Nardev S.; Koenig, Wolfgang; Libby, Peter; Lorenzatti, Alberto J.; Nordestgaard, Borge G.; Shepherd, James; Willerson, James T.; Glynn, Robert J.

2007-01-01

The Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) is a randomized, double-blind, placebo-controlled primary prevention trial of statin therapy among persons with average to low levels of low-density lipoprotein (LDL) cholesterol

Pharmacokinetics of a telmisartan/rosuvastatin fixed-dose combination: a single-dose, randomized, open-label, 2-period crossover study in healthy Korean subjects.

Science.gov (United States)

Chae, Dong Woo; Son, Mijeong; Kim, Yukyung; Son, Hankil; Jang, Seong Bok; Seo, Jeong Min; Nam, Su Youn; Park, Kyungsoo

2015-10-01

As hypertension and dyslipidemia are frequent comorbidities, antihypertensive drugs and lipid-lowering agents are often prescribed together for their treatment. Telmisartan and rosuvastatin are widely used together to treat hypertension and dyslipidemia. A combination formulation of these two drugs would improve patient compliance due to ease of dosing. The purpose of this study was to assess bioequivalence of single-dose administration of a newly-developed fixed-dose combination (FDC) tablet containing telmisartan/rosuvastatin 80/20 mg (test treatment) and coadministration of a telmisartan 80-mg tablet and a rosuvastatin 20-mg tablet (reference treatment) in healthy Korean male volunteers. This was a single-dose, randomized, open-label, 2-period crossover study enrolling healthy males aged 20 - 50 years with BMI between 18.5 and 25 kg/m2. Each subject received a single dose of the reference and test treatments with a 14-day washout period. Blood sampling was performed at prespecified intervals for up to 72 hours after dosing. Primary pharmacokinetic parameters were Cmax, AUClast, and AUC0-∞ of telmisartan, rosuvastatin, and N-desmethyl rosuvastatin. Bioequivalence was assessed by determining whether the 90% confidence intervals (CIs) of the geometric mean ratios (test treatment/reference treatment) of these parameters were within the standard range of 80% to 125%. Adverse events were monitored via regular interviews with the subjects and by physical examinations. 60 subjects were enrolled and 55 completed the study. The 90% CIs of the geometric mean ratios of Cmax, AUClast, and AUC00-∞ were 0.9262-1.1498, 0.9294-1.0313, and 0.9312-1.0320 for telmisartan, 0.9041-1.0428, 0.9262-1.0085, and 0.9307-1.0094 for rosuvastatin, and 0.8718-1.0022, 0.8901-0.9904, and 0.8872-0.9767 for N-desmethyl rosuvastatin, respectively. There was no statistical difference in the incidence of adverse events (AEs) (all of which were mild or moderate) between the reference and test

Multinationality and Opaqueness

DEFF Research Database (Denmark)

Aabo, Tom; Pantzalis, Christos; Park, Jung Chul

2015-01-01

We investigate whether and how multinationality affects the opaqueness of the firm. We use multiple alternative measurements of multinationality and opaqueness. Spanning nearly three decades for a large sample of US non-financial firms, we find a statistically and economically significant, positi...

DIMENSIONS OF MULTINATIONAL ENTERPRISES

Directory of Open Access Journals (Sweden)

Maria - Ramona SARBU

2015-11-01

Full Text Available Capital, creating new jobs, innovation, advanced technologies and the know-how transfer to local firms, human resources with a high level of training, effective management capacity, providing the necessary inputs for the evolution of the activity under the best conditions of efficiency, the access of local consumers to a variety of products and services are the main advantages that multinational enterprises (MNEs bring in the countries where they expand their activities, with a significant impact on economic activities, between national economies. The purpose of this study is the analysis of the main non-financial multinationals in the world, based on the assets held abroad and depending on the transnationality index (TNI in 2013. In order to achieve the purpose of the current paper we employed data from UNCTAD database and the World Investment Report (WIR from 2015. Information on multinationals ranked by foreign assets according to the World Investment Report in 2015 show that, based on the TNI, European multinationals, such as the ones in France, Italy, Germany and Norway, have a higher transnationality index compared to multinationals from larger countries, such as the US and China. Among the top 10 European multinationals, the transnationality index reached an average of 55 % in 2013.

ExStroke Pilot Trial of the effect of repeated instructions to improve physical activity after ischaemic stroke: a multinational randomised controlled clinical trial

DEFF Research Database (Denmark)

Boysen, Gudrun; Krarup, Lars-Henrik; Zeng, Xianrong

2009-01-01

training programme before discharge and at five follow-up visits during 24 months. Control patients had follow-up visits with the same frequency but without instructions in physical activity. MAIN OUTCOME MEASURES: Physical activity assessed with the Physical Activity Scale for the Elderly (PASE) at each......OBJECTIVES: To investigate if repeated verbal instructions about physical activity to patients with ischaemic stroke could increase long term physical activity. DESIGN: Multicentre, multinational, randomised clinical trial with masked outcome assessment. SETTING: Stroke units in Denmark, China...... infarction, or falls and fractures. CONCLUSION: Repeated encouragement and verbal instruction in being physically active did not lead to a significant increase in physical activity measured by the PASE score. More intensive strategies seem to be needed to promote physical activity after ischaemic stroke...

Effect of Atorvastatin vs. Rosuvastatin on cardiac sympathetic nerve activity in non-diabetic patients with dilated cardiomyopathy

Energy Technology Data Exchange (ETDEWEB)

Tsutamoto, Takayoshi; Ibe, Kunihiro [Toyosato Hospital, Toyosato, Shiga (Japan); Sakai, Hiroshi; Yamaji, Masayuki; Kawahara, Chiho; Nakae, Ichiro; Fujii, Masanori; Yamamoto, Takashi; Horie, Minoru [Shiga Univ. of Medical Science, Faculty of Medicine, Otsu, Shiga (Japan)

2011-08-15

Effects of statin therapy on cardiac sympathetic nerve activity in patients with chronic heart failure (CHF) have not previously been evaluated. To compare the effects of lipophilic atorvastatin and hydrophilic rosuvastatin on cardiac sympathetic nerve activity in CHF patients with dilated cardiomyopathy (DCM), 63 stable outpatients with DCM, who were already receiving standard therapy for CHF, were randomized to atorvastatin (n=32) or rosuvastatin (n=31). We evaluated cardiac sympathetic nerve activity by cardiac {sup 123}I-metaiodobenzylguanidine (MIBG) scintigraphy, hemodynamic parameters and neurohumoral factors before and after 6 months of treatment. There were no differences in the baseline characteristics of the 2 groups. In the rosuvastatin group, there were no changes in MIBG parameters, left ventricular ejection fraction or plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) after 6 months of treatment. In contrast, the atorvastatin group showed a significant increase in the delayed heart/mediastinum count ratio (2.18{+-}0.4 vs. 2.36{+-}0.4, P<0.0001), and the washout rate was significantly decreased (34.8{+-}5.7 vs. 32.6{+-}6.3%, P=0.0001) after 6 months of treatment compared with the baseline values. The plasma NT-proBNP level was also significantly decreased (729{+-}858 vs. 558{+-}747 pg/ml, P=0.0139). Lipophilic atorvastatin but not hydrophilic rosuvastatin improves cardiac sympathetic nerve activity in CHF patients with DCM. (author)

Effect of rosuvastatin intensification therapy on blood lipid metabolism, adipocytokines and plaque stability after PCI in ACS patients

Directory of Open Access Journals (Sweden)

Xiu-Quan Sun

2017-10-01

Full Text Available Objective: To explore the effect of rosuvastatin intensification therapy on blood lipid metabolism, adipocytokines and plaque stability after PCI in ACS patients. Methods: ACS patients who received PCI in the hospital between July 2015 and January 2017were reviewed and divided into the routine dose group (n=60 who received rosuvastatin routine dose therapy after PCI and the intensification therapy group (n=46 who received rosuvastatin intensification therapy after PCI. The differences in blood lipid metabolism, adipocytokines and plaque stability were compared between the two groups before and after treatment. Results: Before PCI, the differences in blood lipid metabolism, adipocytokines and plaque stability were not statistically significant between the two groups. 1 month after PCI, lipid metabolism indexes HDL-C and ApoA1 levels in peripheral blood of intensification therapy group were higher than those of routine dose group while LDL-C and ApoB levels were lower than those of routine dose group; adipocytokines APN and Leptin levels in serum were higher than those of routine dose group while Resistin level was lower than that of routine dose group; plaque stability- related indexes ICAM-1, MMP-1 and TIMP-1 levels were lower than those of routine dose group. Conclusion: Rosuvastatin intensification therapy after PCI could effectively regulate the lipid metabolism and increase the plaque stability in ACS patients.

Methodology for clinical trials involving patients with cancer who have febrile neutropenia: updated guidelines of the Immunocompromised Host Society/Multinational Association for Supportive Care in Cancer, with emphasis on outpatient studies.

Science.gov (United States)

Feld, Ronald; Paesmans, Marianne; Freifeld, Alison G; Klastersky, Jean; Pizzo, Philip A; Rolston, Kenneth V I; Rubenstein, Edward; Talcott, James A; Walsh, Thomas J

2002-12-15

Two multinational organizations, the Immunocompromised Host Society and the Multinational Association for Supportive Care in Cancer, have produced for investigators and regulatory bodies a set of guidelines on methodology for clinical trials involving patients with febrile neutropenia. The guidelines suggest that response (i.e., success of initial empirical antibiotic therapy without any modification) be determined at 72 h and again on day 5, and the reasons for modification should be stated. Blinding and stratification are to be encouraged, as should statistical consideration of trials specifically designed for showing equivalence. Patients enrolled in outpatient studies should be selected by use of a validated risk model, and patients should be carefully monitored after discharge from the hospital. Response and safety parameters should be recorded along with readmission rates. If studies use these guidelines, comparisons between studies will be simpler and will lead to further improvements in patient therapy.

Adding exercise training to rosuvastatin treatment: influence on serum lipids and biomarkers of muscle and liver damage.

Science.gov (United States)

Coen, Paul M; Flynn, Michael G; Markofski, Melissa M; Pence, Brandt D; Hannemann, Robert E

2009-07-01

Statin treatment and exercise training can improve lipid profile when administered separately. The efficacy of exercise and statin treatment combined, and its impact on myalgia and serum creatine kinase (CK) have not been completely addressed. The purpose of this study was to determine the effect of statin treatment and the addition of exercise training on lipid profile, including oxidized low-density lipoprotein (oxLDL), and levels of CK and alanine transaminase. Thirty-one hypercholesterolemic and physically inactive subjects were randomly assigned to rosuvastatin (R) or rosuvastatin/exercise (RE) group. A third group of physically active hypercholesterolemic subjects served as an active control group (AC). The R and RE groups received rosuvastatin treatment (10 mg/d) for 20 weeks. From week 10 to week 20, the RE group also participated in a combined endurance and resistive exercise training program (3 d/wk). Lipid profile was determined for all subjects at week 0 (Pre), week 10 (Mid), and week 20 (Post). The CK and alanine transaminase levels were measured at the same time points in the RE and R groups and 48 hours after the first and fifth exercise bout in the RE group. Each RE subject was formally queried about muscle fatigue, soreness, and stiffness before each training session. Total, LDL, and oxLDL cholesterol was lower in the RE and R groups at Mid and Post time points when compared with Pre. Oxidized LDL was lower in the RE group compared with the R group at the Post time point. When treatment groups (R and RE) were combined, high-density lipoprotein levels were increased and triglycerides decreased across time. Creatine kinase increased in the RE group 48 hours after the first exercise bout, but returned to baseline levels 48 hours after the fifth exercise bout. Rosuvastatin treatment decreased total, LDL, and oxLDL cholesterol. The addition of an exercise training program resulted in a further decrease in oxLDL. There was no abnormal sustained increase

Organizational architecture of multinational company

OpenAIRE

Vrbová, Tereza

2012-01-01

The Bachelor's Thesis ,,Organizational architecture of multinational company" sets the target to analyse organizational structures used in multinational companies at present. In the teoretical section is briefly described development of this subject, basic concepts associated with organizational architecture such as globalization, multinational companies and organizational architecture. I also generalized main characteristics of organizational forms and describe their pros and cons. The pract...

Ascorbic acid co-administered with rosuvastatin reduces reproductive impairment in the male offspring from male rats exposed to the statin at pre-puberty.

Science.gov (United States)

Leite, Gabriel Adan Araújo; Figueiredo, Thamiris Moreira; Guerra, Marina Trevizan; Borges, Cibele Dos Santos; Fernandes, Fábio Henrique; Anselmo-Franci, Janete Aparecida; Kempinas, Wilma De Grava

2018-05-18

Obesity during childhood and adolescence is closely related to dysfunctions on lipid profile in children. Rosuvastatin is a statin that decreases serum total cholesterol. Ascorbic acid is an important antioxidant compound for male reproduction. Pre-pubertal male rats were distributed into six experimental groups that received saline solution 0.9% (vehicle), 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid by gavage from post-natal day (PND)23 until PND53. Rats were maintained until adulthood and mated with nulliparous females to obtain the male offspring, whose animals were evaluated at adulthood in relation to reproductive parameters. This study is a follow up of a previous paper addressing potential effects on F0 generation only (Leite et al., 2017). Male offspring from rosuvastatin-exposed groups showed increased sperm DNA fragmentation, androgen depletion and impairment on the testicular and epididymal structure. Ascorbic acid coadministered to the fathers ameliorated the reproductive damage in the offspring. In summary, paternal exposure to rosuvastatin may affect the reproduction in the male offspring; however, paternal supplementation with ascorbic acid was able to reduce the reproductive impairment in the male offspring caused by statin treatment to the fathers. Copyright © 2018 Elsevier Ltd. All rights reserved.

Multinational alternatives and nuclear nonproliferation

International Nuclear Information System (INIS)

Scheinman, L.

1981-01-01

The use of multinational institutional arrangements to control sensitive nuclear-fuel-cycle activities has interested policymakers since the dawn of the nuclear age. Several such ventures have been tried in the past, largely for economic, commercial, or technical reasons, and they have enjoyed varying degrees of success. More recently, with the spread of sensitive nuclear technologies, multinational arrangements have received increasing attention as a means of reinforcing international safeguards which, together with political commitments on peaceful use, have been the principal components of the nonproliferation regime. The political acceptability and efficacy of multinational arrangements is related to the historic experience with multinational ventures, the changed political circumstances of the 1970s, and the probable requirements for constructive future cooperation. As part of a comprehensive regime covering the development of sensitive nuclear activities, multinational arrangements can reinforce the regime in a manner that is widely acceptable. A political effort to win support for such arrangements is thus worthwhile. 29 references

Multinational Risk and Performance Outcomes

DEFF Research Database (Denmark)

Andersen, Torben Juul

2012-01-01

A multinational presence can diversify corporate business activities and provide access to diverse overseas resources. This can enhance operational flexibility and create new business propositions that increase responsiveness to global market changes. Establishing an international corporate...... cross-sectional dataset, we find that flexibility and responsiveness thrives on a multinational presence among firms operating in information-driven knowledge businesses. In contrast, internationalizing firms in capital-based network services display adverse risk effects........ Consistent with the rationales of the OLI paradigm, we argue that multinational reach particularly in knowledge-based industries can reduce downside risk and enhance upside potential. These results introduce more nuances to the ongoing debate about multinational risk and performance effects. Based on a large...

Rosuvastatin does not affect human apolipoprotein A-I expression in genetically modified mice: a clue to the disputed effect of statins on HDL.

Science.gov (United States)

Marchesi, Marta; Parolini, Cinzia; Caligari, Silvia; Gilio, Donatella; Manzini, Stefano; Busnelli, Marco; Cinquanta, Paola; Camera, Marina; Brambilla, Marta; Sirtori, Cesare R; Chiesa, Giulia

2011-11-01

Besides a significant reduction of low-density lipoprotein (LDL) cholesterol, statins moderately increase high-density lipoprotein (HDL) levels. In vitro studies have indicated that this effect may be the result of an increased expression of apolipoprotein (apo)A-I, the main protein component of HDL. The aim of the present study was to investigate in vivo the effect of rosuvastatin on apoA-I expression and secretion in a transgenic mouse model for human apoA-I. Human apoA-I transgenic mice were treated for 28 days with 5, 10 or 20 mg·kg(-1) ·day(-1) of rosuvastatin, the most effective statin in raising HDL levels. Possible changes of apoA-I expression by treatment were investigated by quantitative real-time RT-PCR on RNA extracted from mouse livers. The human apoA-I secretion rate was determined in primary hepatocytes isolated from transgenic mice from each group after treatment. Rosuvastatin treatment with 5 and 10 mg·kg(-1) ·day(-1) did not affect apoA-I plasma levels, whereas a significant decrease was observed in mice treated with 20 mg·kg(-1) ·day(-1) of rosuvastatin (-16%, P < 0.01). Neither relative hepatic mRNA concentrations of apoA-I nor apoA-I secretion rates from primary hepatocytes were influenced by rosuvastatin treatment at each tested dose. In human apoA-I transgenic mice, rosuvastatin treatment does not increase either apoA-I transcription and hepatic secretion, or apoA-I plasma levels. These results support the hypothesis that other mechanisms may account for the observed HDL increase induced by statin therapy in humans. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.

Multinationals and Institutional Competitiveness

DEFF Research Database (Denmark)

Hull Kristensen, Peer; Morgan, Glenn

This article discusses how institutional competitiveness and multinationals are mutually enriching concepts. Seen from the perspective of Multinationals, institutional competitiveness becomes expressed at two levels. At the level of corporate HQs institutional competitiveness proves itself...... competitiveness of Liberal Market Economies and Coordinated Markets Economies under the current competitive regime....

Add-on-Statin Extended Release Nicotinic Acid/Laropiprant but Not the Switch to High-Dose Rosuvastatin Lowers Blood Pressure: An Open-Label Randomized Study

Directory of Open Access Journals (Sweden)

Anastazia Kei

2011-01-01

Full Text Available Introduction. Nicotinic acid (NA and statins have been associated with reductions in blood pressure (BP. Patients and Methods. We recruited 68 normotensive and hypertensive dyslipidemic patients who were treated with a conventional statin dose and had not achieved lipid targets. Patients were randomized to switch to high-dose rosuvastatin (40 mg/day or to add-on current statin treatment with extended release (ER NA/laropiprant (1000/20 mg/day for the first 4 weeks followed by 2000/40 mg/day for the next 8 weeks for 3 months. Results. Switching to rosuvastatin 40 mg/day was not associated with significant BP alterations. In contrast, the addition of ER-NA/laropiprant to current statin treatment resulted in a 7% reduction of systolic BP (from 134±12 to 125±10 mmHg, <.001 versus baseline and =.01 versus rosuvastatin group and a 5% reduction of diastolic BP (from 81±9 to 77±6 mmHg, =.009 versus baseline and =.01 versus rosuvastatin group. These reductions were significant only in the subgroup of hypertensives and were independent of the hypolipidemic effects of ER-NA/laropiprant. Conclusions. Contrary to the switch to high-dose rosuvastatin, the addition of ER-NA/laropiprant to statin treatment was associated with significant reductions in both systolic and diastolic BP.

Facile LC-UV methods for simultaneous monitoring of ciprofloxacin and rosuvastatin in API, formulations and human serum.

Science.gov (United States)

Arayne, M Saeed; Sultana, Najma; Tabassum, Arman

2015-02-01

An efficient, selective and cost-effective liquid chromatographic assay was developed and validated for the simultaneous quantification of ciprofloxacin and rosuvastatin in Active Pharmaceutical Ingredients (API), pharmaceutical formulations and in human serum. The chromatographic system consisted of mobile phase methanol-water, 90:10 v/v at pH 3.0 adjusted with o-phosphoric acid, pumped at 1.0 mL/min through a prepacked Purospher Star C18 (5 µm, 25 × 0.46 cm) column and effluent was monitored at the isosbestic point (255 nm) as well as at the λmax of individual drugs (243 and 271 nm). The method was validated over a linear concentration range of 0.25-15 µg/mL for ciprofloxacin and 0.33-20 µg/mL for rosuvastatin (r(2)  ≥ 0.999). The ranges of reliable response (limits of detection and quantitation) for ciprofloxacin were 3-15 and 9-45 ng/mL and 17-29 and 52-88 ng/mL, respectively, for rosuvastatin in all API, pharmaceutical formulations and human serum. Analytical recovery from human serum was >98% and relative standard deviation (RSD) was <2. The accuracies were 97.13-102.55 and 97.41-101.31% and precisions in RSD were 0.04-1.90 and 0.02-1.23% for ciprofloxacin and rosuvastatin, respectively. No matrix interferences, ion suppression/enhancement and carry-over were detected. The total assay run time was less than 5 min. In another study, for optimum performance the detector was programmed for multiwavelength scanning at the absorption maxima of each component. Consequently, the linearity range was improved and limit of detection and quantitation values were down to 1-4 and 4-12 ng/mL for ciprofloxacin and 3-5 and 9-15 ng/mL for rosuvastatin, respectively. The validation parameters fitted ICH guidelines through the isosbestic and individual λmax approach. The small sample volume and simplicity of preparation make this method suitable for use in human serum samples, pharmaceutical formulations, quality control, drug

Human resource policy and Danish multinational companies

DEFF Research Database (Denmark)

Fleming, Daniel; Søborg, Henrik

A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore.......A study of Danish multinational companies' human resource policy in their subsidiaries in Malaysia and Singapore.The sample of companies consists of 8 Danish multinational companies with activities in both Malaysia and Singapore....

Adding exercise to rosuvastatin treatment: influence on C-reactive protein, monocyte toll-like receptor 4 expression, and inflammatory monocyte (CD14+CD16+) population.

Science.gov (United States)

Coen, Paul M; Flynn, Michael G; Markofski, Melissa M; Pence, Brandt D; Hannemann, Robert E

2010-12-01

Statin treatment and exercise training can reduce markers of inflammation when administered separately. The purpose of this study was to determine the effect of rosuvastatin treatment and the addition of exercise training on circulating markers of inflammation including C-reactive protein (CRP), monocyte toll-like receptor 4 (TLR4) expression, and CD14+CD16+ monocyte population size. Thirty-three hypercholesterolemic and physically inactive subjects were randomly assigned to rosuvastatin (R) or rosuvastatin/exercise (RE) groups. A third group of physically active hypercholesterolemic subjects served as a control (AC). The R and RE groups received rosuvastatin treatment (10 mg/d) for 20 weeks. From week 10 to week 20, the RE group also participated in an exercise training program (3d/wk). Measurements were made at baseline (Pre), week 10 (Mid), and week 20 (Post), and included TLR4 expression on CD14+ monocytes and CD14+CD16+ monocyte population size as determined by 3-color flow cytometry. Serum CRP was quantified by enzyme-linked immunosorbent assay. TLR4 expression on CD14+ monocytes was higher in the R group at week 20. When treatment groups (R and RE) were combined, serum CRP was lower across time. Furthermore, serum CRP and inflammatory monocyte population size were lower in the RE group compared with the R group at the Post time point. When all groups (R, RE, and AC) were combined, TLR4 expression was greater on inflammatory monocytes (CD14+CD16+) compared with classic monocytes (CD14+CD16⁻) at all time points. In conclusion, rosuvastatin may influence monocyte inflammatory response by increasing TLR4 expression on circulating monocytes. The addition of exercise training to rosuvastatin treatment further lowered CRP and reduced the size of the inflammatory monocyte population, suggesting an additive anti-inflammatory effect of exercise. Copyright © 2010 Elsevier Inc. All rights reserved.

Efficacy of 5MG and 10MG rosuvastatin in type-2 diabetes mellitus with hypercholesteroalemia

International Nuclear Information System (INIS)

Ullah, F.; Rahim, F.; Rahman, S.U.; Ashfaq, M.; Afridi, A.K.

2015-01-01

Background: Coronary Heart Disease (CHD) is the most important complication and the leading cause of death in patients with type 2 diabetes mellitus (T2DM). Hypercholesterolemia is an important modifiable risk factor for CHD. Statins are the first line drugs for the treatment of hypercholesterolemia in DM. Comparative studies between different statins are available but different doses of the same statin have not been compared in our population. The objective of this study is to compare mean reduction in serum LDL-C level after using 5mg and 10mg of rosuvastatin among T2DM patients with hypercholesterolemia. This study will help finding lowest effective dose of rosuvastatin to achieve internationally set low density lipoprotein cholesterol (LDL-C) goals. Method: A total of 82 patients with T2DM having fasting LDL-C levels equal or more than 100mg/dl were randomly allocated into two groups with 41 patients in each group. Baseline fasting serum LCL-C levels were obtained in all patients. Group A received 5mg while group B received 10mg of rosuvastatin daily at night. After 6 weeks, fasting LDL-C levels were obtained and analysed to compare the mean±SD reduction of LDL-C levels in both groups. Results: Baseline mean±SD LDL-C levels in group A and group B were 134.12±30.02 and 143.49±32.01 respectively (p 0.176). Follow up mean ± SD LDL-C levels were 81.59±28.47 and 83.24±36.06 respectively (p 0.818). Mean ± SD reduction in LDL-C levels from baseline levels in group A and group B were 52.51±19.49 and 60.20±24.09 (p 0.116). Conclusion: Rosuvastatin 5mg is as effective as 10mg in reducing the LDL-C levels in type 2 diabetic patients with hypercholesterolemia. (author)

Multiple Learning Tracks: For Training Multinational Managers

Science.gov (United States)

Harvey, Michael G.; Kerin, Roger A.

1977-01-01

The problem of identifying and training college students to be effective multinational marketing managers is investigated in three parts: (1) Identification of multinational manager attributes, (2) selection of multinational managers, and (3) multiple "track" training programs. (TA)

Multinational Companies, Technology Spillovers, and Plant Survival

OpenAIRE

Holger Görg; Eric Strobl

2003-01-01

This paper examines the effect of the presence of multinational companies on plant survival in the host country. We postulate that multinational companies can impact positively on plant survival through technology spillovers. We study the nature of the effect of multinationals using a Cox proportional hazard model which we estimate using plant level data for Irish manufacturing industries. Our results show that the presence of multinationals has a life enhancing effect only on indigenous plan...

Emerging Market Multinationals

DEFF Research Database (Denmark)

Gammeltoft, Peter; Hobdari, Bersant

2017-01-01

International knowledge flows and innovation are becoming ever more important to the competitiveness of multinational corporations. Emerging market multinationals (EMNCs) in specific are deploying increasingly activist measures to harness foreign sources of knowledge and innovation as a strategy...... in which this disagreement can be reconciled through recognition of other EMNC advantages, particularly abilities to leverage country-specific assets, and possession and development of dynamic capabilities. Finally, we identify a set of core themes in the recent literature on strategic asset...

Non-proliferation and multinational enterprises

International Nuclear Information System (INIS)

1979-04-01

The paper supplements CC/WG.2/9 in presenting the Japanese delegation's contribution in the areas of non-proliferation and multi-national enterprises. The paper questions whether multinational enrichment enterprises would constitute a significant non-proliferation factor, noting that the nature of the venture might create a potential for the dissemination of sensitive information. The paper also argues that a multi-national venture which was not economically competitive (with national facilities) would have questionable viability. The conclusion is that non-proliferation advantages, if any, would be a result, not an objective of such a venture

Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome.

Science.gov (United States)

Kargiotis, Konstantinos; Athyros, Vasilios G; Giouleme, Olga; Katsiki, Niki; Katsiki, Evangelia; Anagnostis, Panagiotis; Boutari, Chrysoula; Doumas, Michael; Karagiannis, Asterios; Mikhailidis, Dimitri P

2015-07-07

To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis (NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH. This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome (MetS) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients received lifestyle advice and were treated for a 12 mo period with rosuvastatin (10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid (SUA), high sensitivity C reactive protein (hsCRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values. The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20(th), which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3(rd) treatment month (ANOVA P < 0.001), while alkaline phosphatase activities by the 6(th) treatment month (ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced (P < 0.001). Lipid values were normalised by the 3(rd) treatment month. No patient had MetS by the 9(th) treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should

Nato Multinational Brigade Interoperability: Issues, Mitigating Solutions and is it Time for a Nato Multinational Brigade Doctrine?

Directory of Open Access Journals (Sweden)

Schiller Mark

2016-06-01

Full Text Available Multinational Brigade Operations involving NATO and its European Partners are the norm in the post-Cold War Era. Commonplace today are Multinational Brigades, composed of staffs and subordinate units representing almost every NATO Country and Partner, participating in training exercises or actual operations in both the European and Southwest Asian Theatres. Leadership challenges are prevalent for the Multinational Brigade Commander and his staff, especially those challenges they face in achieving an effective level of brigade interoperability in order to conduct successful operations in NATO’s present and future operating environments. The purpose of this paper is twofold: to examine the major interoperability obstacles a multinational brigade commander and his staff are likely to encounter during the planning and execution of brigade operations; and, to recommend actions and measures a multinational brigade commander and his staff can implement to facilitate interoperability in a multinational brigade operating environment. Several key interoperability topics considered integral to effective multinational brigade operations will be examined and analysed to include understanding partner unit capabilities and limitations facilitated by an integration plan, appropriate command and support relationships, compatible communications, synchronized intelligence and information collection, establishing effective liaison, and fratricide prevention. The paper conclusion will urge for a NATO land brigade doctrine considering doctrine’s critical importance to effective brigade command and control interoperability and the expected missions a land brigade will encounter in future NATO operating environments as part of the NATO Very High Readiness Joint Task Force (VJTF.

MULTINATIONAL COMPANIES AND FOREIGN DIRECT INVESTMENT

OpenAIRE

Lucia P. BLĂJUȚ

2014-01-01

This paper highlights the significant share of multinational companies in international trade that are a factor of developing global economies. In the context of economic globalization the activity of multinational companies and their foreign direct investment have a strong impact on the host country which presents advantages and disadvantages for them. The main objective of this article is the review of the important role played by multinationals in economic development, especially in develo...

Atherogenic Lipoprotein Subfractions Determined by Ion Mobility and First Cardiovascular Events After Random Allocation to High-Intensity Statin or Placebo: The Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial.

Science.gov (United States)

Mora, Samia; Caulfield, Michael P; Wohlgemuth, Jay; Chen, Zhihong; Superko, H Robert; Rowland, Charles M; Glynn, Robert J; Ridker, Paul M; Krauss, Ronald M

2015-12-08

Cardiovascular disease (CVD) can occur in individuals with low low-density lipoprotein (LDL) cholesterol (LDL-C). We investigated whether detailed measures of LDL subfractions and other lipoproteins can be used to assess CVD risk in a population with both low LDL-C and high C-reactive protein who were randomized to high-intensity statin or placebo. In 11 186 Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) participants, we tested whether lipids, apolipoproteins, and ion mobility-measured particle concentrations at baseline and after random allocation to rosuvastatin 20 mg/d or placebo were associated with first CVD events (n=307) or CVD/all-cause death (n=522). In placebo-allocated participants, baseline LDL-C was not associated with CVD (adjusted hazard ratio [HR] per SD, 1.03; 95% confidence interval [CI], 0.88-1.21). In contrast, associations with CVD events were observed for baseline non-high-density lipoprotein (HDL) cholesterol (HR, 1.18; 95% CI, 1.01-1.38), apolipoprotein B (HR, 1.28; 95% CI, 1.11-1.48), and ion mobility-measured non-HDL particles (HR, 1.19; 95% CI, 1.05-1.35) and LDL particles (HR, 1.21; 95% CI, 1.07-1.37). Association with CVD events was also observed for several LDL and very-low-density lipoprotein subfractions but not for ion mobility-measured HDL subfractions. In statin-allocated participants, CVD events were associated with on-treatment LDL-C, non-HDL cholesterol, and apolipoprotein B; these were also associated with CVD/all-cause death, as were several LDL and very-low-density lipoprotein subfractions, albeit with a pattern of association that differed from the baseline risk. In JUPITER, baseline LDL-C was not associated with CVD events, in contrast with significant associations for non-HDL cholesterol and atherogenic particles: apolipoprotein B and ion mobility-measured non-HDL particles, LDL particles, and select subfractions of very-low-density lipoprotein particles and

Multinationals and international environmental policy

International Nuclear Information System (INIS)

Dam, L.; Scholtens, B.

2009-01-01

Multinationals with relatively poor environmental policy establish themselves in countries with weak environmental regulation. These activities are not undertaken in the poorest or most corrupt countries though. The question arises if multinationals with relatively developed environmental behavior settle less or more often in countries with environmental legislation. [mk] [nl

Application of Liquisolid Technology for Enhancing Solubility and Dissolution of Rosuvastatin

Directory of Open Access Journals (Sweden)

Pavan Ram Kamble

2014-03-01

Full Text Available Purpose: Rosuvastatin is a poorly water soluble drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Hence it is necessary to increase the solubility of the Rosuvastatin. Methods: Several liquisolid tablets formulations containing various drug concentrations in liquid medication (ranging from 15% to 25% w/w were prepared. The ratio of Avicel PH 102 (carrier to Aerosil 200 (coating powder material was kept 10, 20, 30. The prepared liquisolid systems were evaluated for their flow properties and possible drug-excipient interactions by Infrared spectra (IR analysis, differential scanning calorimetry (DSC and X- ray powder diffraction (XRPD. Results: The liquisolid system showed acceptable flow properties. The IR and DSC studies demonstrated that there is no significant interaction between the drug and excipients. The XRPD analysis confirmed formation of a solid solution inside the compact matrix. The tabletting properties of the liquisolid compacts were within the acceptable limits. Liquisolid compacts demonstrated significantly higher drug release rates than those of conventional and marketed tablet due to increasing wetting properties and surface area of the drug. Conclusion: This study shows that liquisolid technique is a promising alternative for improvement of the dissolution rate of water insoluble drug.

Effects of maximal atorvastatin and rosuvastatin treatment on markers of glucose homeostasis and inflammation

Science.gov (United States)

Recent studies show that statin therapy, while effective at lowering the risk of cardiovascular disease (CVD), may be associated with an increased risk of diabetes. To test the effects of maximal dosages of rosuvastatin and atorvastatin (80mg/day and 40mg/day, respectively) we obtained frozen serum ...

Technology transfer by multinationals

OpenAIRE

Kostyantyn Zuzik

2003-01-01

The paper analyses the issue of technology transfer by multinational corporations. The following questions are explored: (a) world market of technologies, the role of MNCs (b) Choice of the technology transfer mode, Dunning's OLI-theory as a factor of the choice of the mode of transfer (c) measurement and profitability of technology transfer (d) transfer of technology through partnerships, JVs, alliances and through M&As (e) aspects of technology transfer by services multinationals. Paper uti...

Effect of a single gemfibrozil dose on the pharmacokinetics of rosuvastatin in bile and plasma in healthy volunteers.

Science.gov (United States)

Bergman, Ebba; Matsson, Elin M; Hedeland, Mikael; Bondesson, Ulf; Knutson, Lars; Lennernäs, Hans

2010-09-01

The effect of a single intrajejunal dose of gemfibrozil (600 mg) on the plasma pharmacokinetics and biliary excretion of a single intrajejunal dose of rosuvastatin (20 mg) was investigated by using a multichannel catheter positioned in the distal duodenum-proximal jejunum in 8 healthy volunteers. Bile and plasma samples were collected every 20 minutes for 200 minutes, with additional plasma samples being drawn for up to 48 hours. Gemfibrozil did not affect the bioavailability of rosuvastatin, although it increased the apparent absorption phase during the initial 200 minutes (AUC(plasma,200min)) by 1.56-fold (95% confidence interval, 1.14-2.15). The interaction was less pronounced in this single-dose study than in a previous report when gemfibrozil was administered repeatedly; nevertheless, the interaction coincided with the highest exposure to gemfibrozil. The plausible reason why the interaction in this investigation was only minor is the low exposure to gemfibrozil (and its metabolites), suggesting that the total plasma concentration of gemfibrozil needs to be above 20 µM to affect the disposition of rosuvastatin. This study demonstrates the value of monitoring the plasma pharmacokinetics of the inhibitor, and not only the drug under investigation, to improve the mechanistic interpretation.

Effects of short-term rosuvastatin therapy on heart and kidney function in patients with acute coronary syndrome combining diabetes mellitus and concomitant chronic kidney disease

Directory of Open Access Journals (Sweden)

Heng WU

2014-08-01

Full Text Available Objective　To observe the effects and safety of rosuvastatin therapy on protecting the renal and heart function in patients with acute coronary syndrome (ACS combining diabetes mellitus (DM and concomitant chronic kidney disease (CKD undergoing contrast media injection. Methods　Concurrent parallel control and before-after self-control method were employed in present study. From Dec. 2008 to Oct. 2011, 2998 patients from 53 central hospitals in China were enrolled in a TRACK-D project. Out of 2998, 2309 patients with ACS combining DM and concomitant CKD were randomly assigned to rosuvastatin group (n=1183 or control group (n=1126. Patients in rosuvastatin group were given rosuvastatin 10mg/d for five days (two days before and three days post-procedure, while those in control group received no treatment. Isotonic non-ionic contrast medium (iodixanol was used in both groups when angiography, left ventriculography and percutaneous vascular intervention were started. Serum creatinine (Scr, estimated glomerular filtration rate (eGFR and urinary albumin/creatinine ratio (ACR were measured before and 48h, 72h after exposure to contrast medium. A 30-day clinical follow-up was conducted including the evaluation of aggravated heart failure, acute renal failure, dialysis/hemofiltration and all-cause mortality. Results　No significant difference existed between the two groups at the preoperative levels of Scr (95.11±23.79μmol/L vs 94.88±20.31μmol/L, P=0.80 and eGFR [73.98±14.52ml/(min.1.73m2 vs 74.10±13.80ml/(min.1.73m2, P=0.85]. The postoperative Scr level showed no significant difference between the two groups (94.87±25.15μmol/L vs 95.74±30.50μmol/L, P=0.45, however, the postoperative Scr value presented a decline tendency in rosuvastatin group, while an upward trend in control group. The 30-day clinical follow-up found that the incidence of aggravated heart failure was significantly lower in rosuvastatin group than in control group (2.4% vs

The Risk Implications of Multinational Enterprise

DEFF Research Database (Denmark)

Andersen, Torben Juul

2011-01-01

Purpose – Multinational structure has been linked to operational flexibilities that can improve corporate adaptability and a knowledge-based view suggests that multinational resource diversity can facilitate responsive opportunities. The enhanced maneuverability from this can reduce earnings vola...

Taxing the Financially Integrated Multinational Firm

DEFF Research Database (Denmark)

Johannesen, Niels

partly fall on investment and thus workers in the former country. This tax exporting mechanism introduces a scope for corporate taxes, which is not present in standard models of international taxation. Accounting for the internal capital markets of multinational firms thus represents a way to resolve......This paper develops a theoretical model of corporate taxation in the presence of financially integrated multinational firms. Under the assumption that multinational firms at least partly use internal loans to finance foreign investment, we find that the optimal corporate tax rate is positive from...... the perspective of a small, open economy. This finding contrasts the standard result that the optimal source based capital tax is zero. Intuitively, to the extent that multinational firms finance investment in country i with loans from affiliates in country j, the burden of corporate taxes in the latter country...

Neuro, cardio, and reno protective activities of rosuvastatin in streptozotocin-induced type 2 diabetic rats undergoing treatment with metformin and glimepiride

Directory of Open Access Journals (Sweden)

Shailaja Rondi

2014-01-01

Full Text Available Diabetes is associated with complications like neuropathy, nephropathy, cardiomyopathy, and retinopathy due to increased oxidative stress and serum lipids. In the present study, rosuvastatin, a HMG-CoA inhibitor, was investigated for its protective effect in neuropathy, nephropathy, and cardiomyopathy based on the lipid-lowering property along with its pleiotropic effects such as improved blood flow to the organ and antioxidant defense. Type 2 diabetes was induced in Wistar rats by single i.p. administration of streptozotocin (50 mg/kg. These diabetic rats were treated with daily doses of rosuvastatin (10 mg/kg alone, metformin (120 mg/kg and glimepiride (1 mg/kg and rosuvastatin in combination with metformin (120 mg/kg and glimepiride (1 mg/kg for a period of 6 weeks. The biochemical parameters involved in neuropathy, renopathy, and cardiopathy were estimated. Treatment resulted in significant (P < 0.05 decrease in thiobarbituric acid reactive substances (TBARS and increase in levels of glutathione peroxidise and catalase in brain and kidney homogenates. Significant (P < 0.05 increase in high-density lipoproteins and decrease in creatinine kinase, triglycerides, total serum cholesterol represents the cardioprotective action, whereas significant (P < 0.05 increase in the latency in the hotplate model shows the neuroprotective activity, and significant (P < 0.05 decrease in blood urea nitrogen, creatinine levels and increase in serum total protein levels suggested the renoprotective actions. The unique properties of rosuvastatin such as antioxidant defense and lipid-lowering nature might have resulted in cardio, neuro, and renoprotective activity in type 2 diabetic rats treated with metformin and glimepiride.

Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats

Directory of Open Access Journals (Sweden)

Neves Valdir A

2011-09-01

Full Text Available Abstract Background This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin, in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9: 1 standard (STD: fed on casein as protein source; 2 hypercholesterolemic (HC: STD plus 1% cholesterol and 0.5% cholic acid; 3 HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day; 4 HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day; 5 HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3 and (4. The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin and the protein (glycinin were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.

Multinational Firms and The New Trade Theory

OpenAIRE

James R. Markusen; Anthony J. Venables

1995-01-01

A model is constructed in which multinational firms may arise endogenously. Multinationals exist in equilibrium when transport and tariff costs are high, incomes are high, and firm-level scale economies are important relative to plant-level scale economies. Less obvious, multinationals are more important in total economic activity when countries are more similar in incomes, relative factor endowments, and technologies. The model may thus be useful in explaining several stylized facts, includi...

How powerful are the multinational corporations?

OpenAIRE

Pausenberger, Ehrenfried

1983-01-01

Much unease, distrust and criticism is being expressed in the current debate about the potential power of multinational corporations and the possibilities of abuse. What is the basis for the power of the multinationals, and what possibilities are available for controlling and limiting that power?

Forming a multinational joint venture

International Nuclear Information System (INIS)

Bhatia, N.K.; Garb, R.H.; Statton, T.D.

1990-01-01

This paper discusses the basis and mechanics for forming a multinational joint venture. The topics of the paper include the motivations for a joint venture, selection of the appropriate co-venturer, management of the multinational joint venture, and the joint venture agreement. The authors state that a joint venture is not applicable or desirable in all instances and to be successful, must be carefully planned

Lending Behavior of Multinational Bank Affiliates

Czech Academy of Sciences Publication Activity Database

Derviz, Alexis; Podpiera, J.

2011-01-01

Roč. 1, č. 1 (2011), s. 19-36 ISSN 2077-429X Institutional research plan: CEZ:AV0Z10750506 Keywords : Multinational bank * Contagion * Substitution * Agency Subject RIV: AH - Economics http://library.utia.cas.cz/separaty/2011/E/derviz-lending behavior of multinational bank affiliates.pdf

The Foreign Exchange Exposure of Japanese Multinational ...

African Journals Online (AJOL)

The Foreign Exchange Exposure of Japanese Multinational Corporations. ... African Journal of Finance and Management ... We also find that keiretsu multinationals are more exposed to exchange rate risk that non-keiretsu firms.

Use of a combination of prednisolone and rosuvastatin for treatment of a pyogranuloma in a dog.

Science.gov (United States)

Yuki, Masashi; Hirano, Takashi

2010-04-01

A 6-year-old spayed female Miniature Dachshund was examined because of a 3-day history of anorexia and diarrhea. A lump was detected during abdominal palpation. Biochemical abnormalities included increases in serum concentrations of total protein, globulin, and C-reactive protein (CRP). Abdominal radiography and abdominal ultrasonography revealed a mass on the caudal aspect of the right kidney. Exploratory laparotomy confimed the mass; however, it could not be excised because it was strongly adhered to surrounding tissues. Histologic examination of a tissue sample from the mass led to a diagnosis of pyogranuloma. The dog was treated with rosuvastatin, but no improvement was evident. Administration of a high dose of prednisolone (1 mg/kg [0.45 mg/lb], PO, q 12 h) was initiated. The CRP concentration returned to within reference limits, and the mass gradually decreased in size. The prednisolone dosage was tapered to 0.14 mg/kg (0.064 mg/lb), PO, every 12 hours. However, once the low dosage of prednisolone was reached, CRP concentration and size of the mass increased. Rosuvastatin was subsequently combined with the low dosage of prednisolone. After 1 week of the combination treatment, the CRP concentration returned to within reference limits, and the mass was reduced in size. The mass eventually could not be detected ultrasonographically. A low dose of prednisolone was not effective against the pyogranuloma. However, administration of a low dose of prednisolone in combination with rosuvastatin caused decreases in CRP concentration and size of the pyogranuloma. Thus, statins may act as immunosuppressants.

Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. Evaluation using dual-source computed tomography

International Nuclear Information System (INIS)

Soeda, Tsunenari; Uemura, Shiro; Okayama, Satoshi

2011-01-01

Clinical studies using invasive modalities have reported that statin therapy stabilizes coronary plaque vulnerability. The serial changes of lipid-rich coronary plaques (LRCPs) during rosuvastatin treatment were evaluated non-invasively in patients with acute coronary syndrome (ACS) using dual-source computed tomography (DSCT). A total of 11 consecutive ACS patients, and 13 LRCPs were serially evaluated on DSCT before and 24 weeks after rosuvastatin treatment. Compared with the baseline, there was no change in post-treatment minimal lumen diameter, lumen volume, or longitudinal length of LRCPs. By contrast, the ratio of lipid core volume to plaque volume significantly decreased from 48.0±9.9% to 43.7±10.6% (P=0.04), and plaque volume decreased from 144.5±85.5 mm 3 to 119.8±78.0 mm 3 (P=0.07). The remodeling index of target LRCPs significantly decreased from 1.16±0.10 to 1.06±0.12 (P=0.02). Percent reduction of plaque volume was significantly greater in patients with a lower ratio of low-density lipoprotein to high-density lipoprotein (L/H ratio ≤1.5) at follow-up than patients with higher L/H ratio (>1.5; median -31.7% vs. -6.8%, P=0.03). Rosuvastatin therapy reduced the volume of lipid cores and LRCPs and increased the CT attenuation value of LRCPs. DSCT is an effective modality for the non-invasive evaluation of LRCPs in patients with ACS. (author)

Sustained Improvement of Arterial Stiffness and Blood Pressure after Long-Term Rosuvastatin Treatment in Patients with Inflammatory Joint Diseases: Results from the RORA-AS Study.

Directory of Open Access Journals (Sweden)

Eirik Ikdahl

Full Text Available Patients with inflammatory joint diseases (IJD have a high prevalence of hypertension and increased arterial stiffness. The aim of the present study was to evaluate the effect of long-term rosuvastatin treatment on arterial stiffness, measured by augmentation index (AIx and aortic pulse wave velocity (aPWV, and blood pressure (BP in IJD patients with established atherosclerosis.Eighty-nine statin naïve IJD patients with carotid atherosclerotic plaque(s (rheumatoid arthritis n = 55, ankylosing spondylitis n = 23, psoriatic arthritis n = 11 received rosuvastatin for 18 months to achieve low-density lipoprotein cholesterol goal ≤1.8 mmol/L. Change in AIx (ΔAIx, aPWV (ΔaPWV, systolic BP (ΔsBP and diastolic BP (ΔdBP from baseline to study end was assessed by paired samples t-tests. Linear regression was applied to evaluate associations between cardiovascular disease (CVD risk factors, rheumatic disease specific variables and medication, and ΔAIx, ΔaPWV, ΔsBP and ΔdBP.AIx, aPWV, sBP and dBP were significantly reduced from baseline to study end. The mean (95%CI changes were: ΔAIx: -0.34 (-0.03, -0.65% (p = 0.03, ΔaPWV: -1.69 (-0.21, -3.17 m/s2 (p = 0.03, ΔsBP: -5.27 (-1.61, -8.93 mmHg (p = 0.004 and ΔdBP -2.93 (-0.86, -5.00 mmHg (p = 0.01. In linear regression models, ∆aPWV was significantly correlated with ΔsBP and ΔdBP (for all: p<0.001.There is an unmet need of studies evaluating CVD prevention in IJD patients. We have shown for the first time that long-term intensive lipid lowering with rosuvastatin improved arterial stiffness and induced a clinically significant BP reduction in patients with IJD. These improvements were linearly correlated and may represent novel insight into the pleiotropic effects by statins.ClinicalTrials.gov NCT01389388.

Multinational Oil Companies and Corporate Social Responsibilities ...

African Journals Online (AJOL)

Niger Delta Region, Nigeria), the concept of corporate social responsibility must be fully imbibed by the multinational oil companies. Therefore, this study examines multinational oil companies and corporate social responsibilities with particular ...

Corporate Taxation and Multinational Activity

OpenAIRE

Peter Egger; Simon Loretz; Michael Pfaffermayr; Hannes Winner

2009-01-01

This paper assesses the impact of corporate taxation on multinational activity. A numerically solvable general equilibrium model of trade and multinational firms is used to incorporate the following components of corporate taxation: parent and host country statutory corporate tax rates, withholding tax rates, and parent and host country depreciation allowances. We account for their differential impact under alternative methods of double taxation relief (i.e., credit, exemption, and deduction)...

Lean Transformation of Multinational Concerns

DEFF Research Database (Denmark)

Matthiesen, Rikke Vestergaard; Johansen, John

2008-01-01

triggered. This paper reports on exploratory studies from a multinational company adopting centrally managed pilot projects as a transformation mechanism for continuous change towards a lean business system and an organizational culture of continuous improvements (CI). Competitive pressure demands...... from a multinational company adopting centrally managed pilot projects as a transformation mechanism for continuous change towards a lean business system and an organizational culture of continuous improvements (CI)....

Organizational architecture of multinational companies

OpenAIRE

Sikorová, Lenka

2009-01-01

The main goal of the bachelor thesis Organizational Architecture of Multinational Companies is to elaborate the overview of organizational structures that are used by modern global companies. The thesis contains an analysis of such companies development, principles of functioning, pros and cons and the opportunities which these brings. It also contains a description of the basic concepts associated with organizational architecture such as globalization, multinational companies and organizatio...

Innovation and Institutional Embeddedness of Multinational Corporations

DEFF Research Database (Denmark)

Pogrebnyakov, Nicolai

2014-01-01

Review of: Innovation and Institutional Embeddedness of Multinational Corporations / edited by Martin Heidenreich. (Cheltenham: Edward Elgar, 2012)......Review of: Innovation and Institutional Embeddedness of Multinational Corporations / edited by Martin Heidenreich. (Cheltenham: Edward Elgar, 2012)...

Constitutional orders in multinational firms

DEFF Research Database (Denmark)

Hull Kristensen, Peer; Morgan, Glenn

Multinationals are faced with the problem of how to coordinate different actors and stop `fiefdoms' emerging that inhibits the achievement of transnational cooperation? We identify this as a problem of `constitutional ordering' in the firm. Drawing on Varieties of Capitalism approaches, we explore...... how multinationals from different contexts seek to create constitutional orders. We argue that the models which exist appear to be destructive of coordination. We explore the implications for MNCs....

Corporate Responsible Behavior in Multinational Enterprise

DEFF Research Database (Denmark)

Andersen, Torben Juul

2017-01-01

Purpose: This study aims to analyze how leadership influenced corporate responsible behavior in a complex multinational organization with ethical principles imposed by concrete actions on regulatory, environmental and international labor issues. Increasing functional specialization, multinational...... diversification and global expansion also diluted those values. Originality/value: Corporate responsible behavior is a significant challenge in large organizations with many and diverse multinational stakeholders. Ethical conduct derives from executive morality, but the role of leaders as instigators...... diversity and business acquisitions challenged the core values and called for more formal enforcement. Core values executed through investment in positive economic externalities enhanced the reputation and facilitated sustainable collaborative solutions. Design/methodology/approach: This single-case study...

Effective Strategy-Making in Multinational Subsidiaries

DEFF Research Database (Denmark)

Andersen, Torben Juul; Andersson, Ulf; Palmié, Maximilian

for global efficiencies and autonomy for effective local responses. Strategic guidance from headquarters frames subsidiary decisions in line with corporate priorities and distributed decision power coupled with informal exchange of information facilitates strategic responses in tune with local market......We outline commonalities between studies of subsidiary decentralization and autonomous strategy-making in the international business and strategic management fields. This suggests that corporate headquarters should engage in strategy-making processes that provide a combination of formal direction...... requirements. We identify some important nuances in the integration-responsiveness conundrum supported by an empirical study of 351 multinational subsidiaries. We discuss the implications for multinational strategy practice and suggest future research venues to investigate strategy-making in multinational...

Successes and Challenges of Emerging Economy Multinationals

DEFF Research Database (Denmark)

Successes and Challenges of Emerging Economy Multinationals investigates a broad variety of cases presenting clear evidence of fast successful internationalization of emerging economy multinationals originating not only from big economic players such as China, India and Russia but also from other...... successfully internationalizing emerging countries, namely South Africa and Poland. In terms of size, the firms vary from huge multinational firms such as Huawei, Tata and Gazprom, to really small high technology firms. The in-depth analysis conducted in this book leads to the indication of numerous novel...

Solubility of rosuvastatin calcium in different neat solvents at different temperatures

International Nuclear Information System (INIS)

Alshora, Doaa H.; Haq, Nazrul; Alanazi, Fars K.; Ibrahim, Mohamed A.; Shakeel, Faiyaz

2016-01-01

Highlights: • Solubility of rosuvastatin calcium (ROSCa) in seven neat solvents was determined. • The solubility of ROSCa was recorded highest in propylene glycol. • Experimental solubilities were correlated with Apelblat and ideal models. • Good correlation was existed between experimental and calculated solubilities. - Abstract: In the current research work, the solubility of rosuvastatin calcium (ROSCa) in seven different neat solvents such as water, ethanol, 1-butanol, 2-butanol, ethylene glycol (EG), isopropyl alcohol (IPA) and propane-1,2-diol (PG) was measured at five different temperatures i.e. T = (298.15 to 318.15) K and atmospheric pressure. Values of the experimental solubility of ROSCa were correlated with Apelblat and ideal models which showed good correlation and model fitting. The solubility (as mole fraction) of ROSCa was recorded highest in PG (1.89 · 10"−"2 at T = 318.15 K) followed by 1-butanol (8.20 · 10"−"4 at T = 318.15 K), ethanol (6.81 · 10"−"4 at T = 318.15 K), IPA (5.66 · 10"−"4 at T = 318.15 K), EG (5.03 · 10"−"4 at T = 318.15 K), 2-butanol (1.08 · 10"−"4 at T = 318.15 K) and water (1.40 · 10"−"5 at T = 318.15 K). The experimental results from this research work would be helpful in the development of conventional and advanced liquid dosage forms of ROSCa.

Cultural Penetration in Latin America through Multinational Advertising Agencies.

Science.gov (United States)

Del Toro, Wanda

Few studies have addressed the issue of cultural penetration of Latin American countries by multinational corporations (MNCs) and multinational advertising agencies (MAAs). Whether they are considered multinational or transnational, MAAs have expanded as a form of international communication in the global market, forming the backbone of MNCs.…

Multinationality as real option facilitator – Illusion or reality?

DEFF Research Database (Denmark)

Aabo, Tom; Pantzalis, Christos; Park, Jung Chul

2016-01-01

Previous literature provides multiple conflicting arguments on why and when multinationality should enhance or impede the value-relevance of firms’ real options. We address this issue by examining whether the relationship between stock returns and changes in return volatility varies with multinat......Previous literature provides multiple conflicting arguments on why and when multinationality should enhance or impede the value-relevance of firms’ real options. We address this issue by examining whether the relationship between stock returns and changes in return volatility varies...... with multinationality. Our results indicate that multinationality does indeed act as a real option facilitator. Furthermore, we show that, consistent with the notion that there are limits to the operating flexibility associated with multinationality this benefit only accrues fully if the firm is not financially...

A mechanistic framework for in vitro-in vivo extrapolation of liver membrane transporters: prediction of drug-drug interaction between rosuvastatin and cyclosporine.

Science.gov (United States)

Jamei, M; Bajot, F; Neuhoff, S; Barter, Z; Yang, J; Rostami-Hodjegan, A; Rowland-Yeo, K

2014-01-01

The interplay between liver metabolising enzymes and transporters is a complex process involving system-related parameters such as liver blood perfusion as well as drug attributes including protein and lipid binding, ionisation, relative magnitude of passive and active permeation. Metabolism- and/or transporter-mediated drug-drug interactions (mDDIs and tDDIs) add to the complexity of this interplay. Thus, gaining meaningful insight into the impact of each element on the disposition of a drug and accurately predicting drug-drug interactions becomes very challenging. To address this, an in vitro-in vivo extrapolation (IVIVE)-linked mechanistic physiologically based pharmacokinetic (PBPK) framework for modelling liver transporters and their interplay with liver metabolising enzymes has been developed and implemented within the Simcyp Simulator(®). In this article an IVIVE technique for liver transporters is described and a full-body PBPK model is developed. Passive and active (saturable) transport at both liver sinusoidal and canalicular membranes are accounted for and the impact of binding and ionisation processes is considered. The model also accommodates tDDIs involving inhibition of multiple transporters. Integrating prior in vitro information on the metabolism and transporter kinetics of rosuvastatin (organic-anion transporting polypeptides OATP1B1, OAT1B3 and OATP2B1, sodium-dependent taurocholate co-transporting polypeptide [NTCP] and breast cancer resistance protein [BCRP]) with one clinical dataset, the PBPK model was used to simulate the drug disposition of rosuvastatin for 11 reported studies that had not been used for development of the rosuvastatin model. The simulated area under the plasma concentration-time curve (AUC), maximum concentration (C max) and the time to reach C max (t max) values of rosuvastatin over the dose range of 10-80 mg, were within 2-fold of the observed data. Subsequently, the validated model was used to investigate the impact of

Effect of Steady-State Faldaprevir on Pharmacokinetics of Atorvastatin or Rosuvastatin in Healthy Volunteers: A Prospective Open-Label, Fixed-Sequence Crossover Study.

Science.gov (United States)

Huang, Fenglei; Marzin, Kristell; Koenen, Rüdiger; Kammerer, Klaus Peter; Strelkowa, Natalja; Elgadi, Mabrouk; Quinson, Anne-Marie; Haertter, Sebastian

2017-10-01

Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus protease. It inhibits multiple cytochrome P-450 enzymes and multiple membrane transporters. The objective of this study was to evaluate the effect of steady-state faldaprevir on the pharmacokinetics (PK) of a single dose of atorvastatin or rosuvastatin. In this single-center, open-label, fixed-sequence crossover study, 33 healthy adult male and female volunteers were given either atorvastatin 10 mg (n = 16) or rosuvastatin 10 mg (n = 17) on day 1. Subjects subsequently received 240 mg twice daily of faldaprevir (loading dose) on day 5, followed by 240 mg faldaprevir once daily from day 6 to day 10, with an additional single dose of atorvastatin (10 mg) or rosuvastatin (10 mg) given on day 10. PK samples for the statins were collected on days 1-3 and days 10-12. Concomitant administration with faldaprevir led to approximately 9-fold and 34-fold increases in AUC 0-∞ and C max , respectively, of atorvastatin and approximately 15-fold and 33-fold increases in AUC 0-∞ and C max , respectively, of rosuvastatin, compared with the statins given alone. Exposure to the major metabolites (ortho-hydroxyatorvastatin and N-desmethylrosuvastatin) was increased to a similar magnitude as that of the parent compounds. The marked drug-drug interaction observed is most likely related to the inhibitory effects of faldaprevir on transporters, particularly hepatic uptake transporters such as OTAP1B1 and OATP1B3. Given the significant increase in exposure to statins in healthy volunteers, coadministration of faldaprevir with statins should be avoided. © 2017, The American College of Clinical Pharmacology.

Toward Unity of Command for Multinational Air Forces

National Research Council Canada - National Science Library

Asjes, David

1998-01-01

To assure unity of command in future multinational air operations, combatant commanders must embrace the necessity of multinational air forces, maximize the integration of allied officers within air...

Rosuvastatin lowers coenzyme Q10 levels, but not mitochondrial adenosine triphosphate synthesis, in children with familial hypercholesterolemia

NARCIS (Netherlands)

Avis, Hans J.; Hargreaves, Ian P.; Ruiter, Jos P. N.; Land, John M.; Wanders, Ronald J.; Wijburg, Frits A.

2011-01-01

To investigate whether statin therapy affects coenzyme Q10 (CoQ10) status in children with heterozygous familial hypercholesterolemia (FH). Samples were obtained at baseline (treatment naïve) and after dose titration with rosuvastatin, aiming for a low-density lipoprotein cholesterol level of 110

Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study

NARCIS (Netherlands)

Braamskamp, Marjet J. A. M.; Langslet, Gisle; McCrindle, Brian W.; Cassiman, David; Francis, Gordon A.; Gagné, Claude; Gaudet, Daniel; Morrison, Katherine M.; Wiegman, Albert; Turner, Traci; Kusters, D. Meeike; Miller, Elinor; Raichlen, Joel S.; Wissmar, Jenny; Martin, Paul D.; Stein, Evan A.; Kastelein, John J. P.

2015-01-01

Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant disorder leading to premature atherosclerosis. Guidelines recommend initiating statins early to reduce low-density lipoprotein cholesterol (LDL-C). Studies have evaluated rosuvastatin in children aged ≥10 years, but its

MULTINATIONAL COMPANIES AND FOREIGN DIRECT INVESTMENT

Directory of Open Access Journals (Sweden)

Lucia P. BLĂJUȚ

2014-11-01

Full Text Available This paper highlights the significant share of multinational companies in international trade that are a factor of developing global economies. In the context of economic globalization the activity of multinational companies and their foreign direct investment have a strong impact on the host country which presents advantages and disadvantages for them. The main objective of this article is the review of the important role played by multinationals in economic development, especially in developed economies. In the economies in which they operate, they bring capital, technology transfer, improve the national reputation and influence the other companies to invest in this countries, they provide a substantial source of revenue for the government and always improve the balance of payments in the host country.

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial.

Science.gov (United States)

Ridker, Paul M; Genest, Jacques; Boekholdt, S Matthijs; Libby, Peter; Gotto, Antonio M; Nordestgaard, Børge G; Mora, Samia; MacFadyen, Jean G; Glynn, Robert J; Kastelein, John J P

2010-07-31

HDL-cholesterol concentrations are inversely associated with occurrence of cardiovascular events. We addressed, using the JUPITER trial cohort, whether this association remains when LDL-cholesterol concentrations are reduced to the very low ranges with high-dose statin treatment. Participants in the randomised placebo-controlled JUPITER trial were adults without diabetes or previous cardiovascular disease, and had baseline concentrations of LDL cholesterol of less than 3.37 mmol/L and high-sensitivity C-reactive protein of 2 mg/L or more. Participants were randomly allocated by a computer-generated sequence to receive rosuvastatin 20 mg per day or placebo, with participants and adjudicators masked to treatment assignment. In the present analysis, we divided the participants into quartiles of HDL-cholesterol or apolipoprotein A1 and sought evidence of association between these quartiles and the JUPITER primary endpoint of first non-fatal myocardial infarction or stroke, hospitalisation for unstable angina, arterial revascularisation, or cardiovascular death. This trial is registered with ClinicalTrials.gov, number NCT00239681. For 17,802 patients in the JUPITER trial, rosuvastatin 20 mg per day reduced the incidence of the primary endpoint by 44% (p<0.0001). In 8901 (50%) patients given placebo (who had a median on-treatment LDL-cholesterol concentration of 2.80 mmol/L [IQR 2.43-3.24]), HDL-cholesterol concentrations were inversely related to vascular risk both at baseline (top quartile vs bottom quartile hazard ratio [HR] 0.54, 95% CI 0.35-0.83, p=0.0039) and on-treatment (0.55, 0.35-0.87, p=0.0047). By contrast, among the 8900 (50%) patients given rosuvastatin 20 mg (who had a median on-treatment LDL-cholesterol concentration of 1.42 mmol/L [IQR 1.14-1.86]), no significant relationships were noted between quartiles of HDL-cholesterol concentration and vascular risk either at baseline (1.12, 0.62-2.03, p=0.82) or on-treatment (1.03, 0.57-1.87, p=0.97). Our analyses

The expatriates in multinational companies: A trend in Serbia

Directory of Open Access Journals (Sweden)

Ratković Tatjana

2014-01-01

Full Text Available Expansion of international operations has imposed new demands to multinational companies, especially in the area of human resource management. International human resource management is primarily characterized by movement of employees across the boundaries of one country in order to take various roles in foreign subsidiaries of multinational companies. One of the most important decisions a multinational company has to make refers to selection of employees to fill in positions in its foreign subsidiaries depending on nationality of employees. This paper tends to explore the significance and roles of expatriates in obtaining success of multinational company in international operations in order to emphasize the advantages expatriates may bring to a multinational company. This paper aims to analyze one of crucial issues that multinational companies face in global environment - the process of expatriation, particularly focusing on the number of expatriates (parent country nationals in subsidiaries of foreign multinational companies in Serbia and the tendency of changing their number in these subsidiaries, as well as nationality of managers in key positions in these subsidiaries (CEO and HR manager. Empirical research performed through a questionnaire has shown certain features of subsidiaries of multinational companies in Serbia, indicating that the number of expatriates has increased since their founding until today (contrary to expectations based on theoretical concepts and results of studies performed in other countries and environments. However, as it was expected, the analysis of results has shown that most subsidiaries in Serbia have replaced their expatriates in the position of CEO (and HR manager, which has brought companies numerous benefits, such as lower expenses.

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?

Directory of Open Access Journals (Sweden)

Kim CO

2017-02-01

Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Hohyun Kim,3 Min Soo Park1,4 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicine and Regulatory Sciences, College of Medicine and Pharmacy, Yonsei University, Incheon, 3Korea Medicine Research Institute, Inc., Seongnam, 4Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea Abstract: To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK interactions between these two drugs in healthy males and to explore the effect of SLCO1B1 and CYP2C9 polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part. All subjects (n=24 completed part 1, and 22 subjects completed part 2. A total of 38 subjects among the participants of the PK interaction studies were enrolled in the genotype study to analyze their SLCO1B1 and CYP2C9 polymorphisms retrospectively (n=22 in part 1, n=16 in part 2. Comparison of the PK and safety of each drug alone with those of the drugs in combination showed that both glimepiride and rosuvastatin did not interact with each other and had tolerable safety profiles in all subjects. However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss and area under the plasma concentration–time curve during the dose interval at steady state (AUCt,ss for glimepiride in combination with rosuvastatin than those for glimepiride alone. However, other significant effects of the SLCO1B1 or CYP2C9 polymorphism on the interaction between the two drugs were not observed. In conclusion, there were no significant PK

International Competition for Foreign Multinational Investment,

OpenAIRE

Jan I. Haaland; Ian Wooton

1998-01-01

We examine the economic justification for providing investment subsidies to foreign-owned multinationals. These provide employment opportunities and generate demand for domestic intermediate inputs, produced by domestic workers with increasing returns to scale. Offering subsidies to multinationals may be in the national interest if the investment raises the net value of domestic production. When agglomerative forces are sufficiently strong, a subsidy that attracts the first foreign firm may i...

Pooling of cross-cultural PRO data in multinational clinical trials: how much can poor measurement affect statistical power?

Science.gov (United States)

Regnault, Antoine; Hamel, Jean-François; Patrick, Donald L

2015-02-01

Cultural differences and/or poor linguistic validation of patient-reported outcome (PRO) instruments may result in differences in the assessment of the targeted concept across languages. In the context of multinational clinical trials, these measurement differences may add noise and potentially measurement bias to treatment effect estimation. Our objective was to explore the potential effect on treatment effect estimation of the "contamination" of a cultural subgroup by a flawed PRO measurement. We ran a simulation exercise in which the distribution of the score in the overall sample was considered a mixture of two normal distributions: a standard normal distribution was assumed in a "main" subgroup and a normal distribution which differed either in mean (bias) or in variance (noise) in a "contaminated" subgroup (the subgroup with potential flaws in the PRO measurement). The observed power was compared to the expected power (i.e., the power that would have been observed if the subgroup had not been contaminated). Even if differences between the expected and observed power were small, some substantial differences were obtained (up to a 0.375 point drop in power). No situation was systematically protected against loss of power. The impact of poor PRO measurement in a cultural subgroup may induce a notable drop in the study power and consequently reduce the chance of showing an actual treatment effect. These results illustrate the importance of the efforts to optimize conceptual and linguistic equivalence of PRO measures when pooling data in international clinical trials.

Organization of multinational undertakings in the nuclear field

International Nuclear Information System (INIS)

Yajima, Masayuki

1982-01-01

Various proposals have been put forward to establish multinational undertakings for enrichment, fuel fabrication, reprocessing, spent fuel storage and waste management. The purpose of this paper is to investigate the legal, institutional framework aspects of multinational undertakings in the field of nuclear fuel cycle. The selection of the appropriate bodies representing the interest of participating countries would largely depend on the object or role of multinational undertakings. Regarding the principle of formation, URENCO is a much informative model of formation, which distinguishes the equity participation at national level and multinational level. The allocation of service between equity participants and non-equity participants depends on the objective of establishing business. Some priority in service allocation should be given to equity participants, and the participants having non-proliferation objective may require service allocation to avoid proliferation risk. The degree of achieving non-proliferation goal is related to the scope of participation. The experience in the field of nuclear energy seems to suggest that the concept of two-tiered decisionmaking structure is generally accepted. Various legal instruments appropriate to constitute multinational fuel cycle arrangement were examined, referring to the precedents and experience. (Kako, I.)

International HR Strategy of Brazilian Technology Multinationals

Directory of Open Access Journals (Sweden)

Patricia Morilha Muritiba

2010-10-01

Full Text Available Four cases of Brazilian Multinationals from the information technology [IT] sector were compared in their international Human Resources strategy. The analysis is focused on the development and application of two research models. One analyzes the level of subsidiary autonomy in terms of strategic HR decisions, including difficult decisions regarding coordination in multinationals, following the theoretical approach of the autonomy of subsidiaries (Kidger, 2002; Nohria & Ghoshal, 1997. The other is related to the level of internationalization of HR strategies, defined as the capacity to take advantage of globalization, providing the best resources for the company regardless of where they are located (Sparrow, 2007. Both models were applied in a multiple case study method (Eisenhardt, 1989. Data were collected through semi-structured interviews and company reports, and analyzed through content analysis. The results show: (a a more centralizing characteristic of the multinational companies examined, despite the limitations of this choice as shown by the literature; and (b that Brazilian IT multinationals tend to rely more on their national competencies when managing human resources instead of going global to aggregate differentiated competencies.

A comparative study of efficacy of atorvastatin, rosuvastatin, and atorvastatin + fibrates as lipid lowering agents

OpenAIRE

Karunasree Nagarur; Yamini Vadlamannati; Narasimha Rao Raja

2016-01-01

Background: Hypercholesterolemia patients are at high risk of coronary heart disease. National cholesterol education programme (NCEP) Adult Treatment Panel III guidelines provide the option of aggressively lowering Low-density cholesterol in them. Presently the standard therapy of hypercholesterolemia is by HMG co-A reductase inhibitors. Present study shows that Rosuvastatin is better than Atorvastatin, Atorvastatin and Fibrate is better than Atorvastatin monotherapy in management of hypercho...

Nationality Divides and Shared Leadership in Multinational Teams

DEFF Research Database (Denmark)

Paunova, Minna

2015-01-01

How shared leadership is enacted in teams that are nationally diverse is currently under- researched, despite the increasing presence of multinational teams in the workplace. To better understand the phenomenon of shared leadership in multinational team contexts, we propose two ways in which...

The Multinational Firm

DEFF Research Database (Denmark)

Morgan, Glenn; Hull Kristensen, Peer; Whitley, Richard

. These processes occur at a number of levels which are explored in different empirical settings. Firstly, at the level of governance, multinational firms may develop conflicts between investors from different national contexts, for example between the arms-length orientation of Anglo-Saxon institutional investors...

Multinational Quality Assurance

Science.gov (United States)

Kinser, Kevin

2011-01-01

Multinational colleges and universities pose numerous challenges to the traditional models of quality assurance that are designed to validate domestic higher education. When institutions cross international borders, at least two quality assurance protocols are involved. To guard against fraud and abuse, quality assurance in the host country is…

Multinationals' Political Activities on Climate Change

International Nuclear Information System (INIS)

Kolk, A.; Pinkse, J.

2007-01-01

This article explores the international dimensions of multinationals' corporate political activities, focusing on an international issue - climate change - being implemented differently in a range of countries. Analyzing data from Financial Times Global 500 firms, it examines the influence on types and process of multinationals' political strategies, reckoning with institutional contexts and issue saliency. Findings show that the type of political activities can be characterized as an information strategy to influence policy makers toward market-based solutions, not so much withholding action on emission reduction. Moreover, multinationals pursue self-regulation, targeting a broad range of political actors. The process of political strategy is mostly one of collective action. International differences particularly surface in the type of political actors aimed at, with U.S. and Australian firms focusing more on non-government actors (voluntary programs) than European and Japanese firms. Influencing home-country (not host-country) governments is the main component of international political strategy on climate change

A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT: study protocol and design of a randomized controlled trial

Directory of Open Access Journals (Sweden)

Kruger Peter

2011-03-01

Full Text Available Abstract Background Swine origin influenza A/H1N1 infection (H1N1 emerged in early 2009 and rapidly spread to humans. For most infected individuals, symptoms were mild and self-limited; however, a small number developed a more severe clinical syndrome characterized by profound respiratory failure with hospital mortality ranging from 10 to 30%. While supportive care and neuraminidase inhibitors are the main treatment for influenza, data from observational and interventional studies suggest that the course of influenza can be favorably influenced by agents not classically considered as influenza treatments. Multiple observational studies have suggested that HMGCoA reductase inhibitors (statins can exert a class effect in attenuating inflammation. The Collaborative H1N1 Adjuvant Treatment (CHAT Pilot Trial sought to investigate the feasibility of conducting a trial during a global pandemic in critically ill patients with H1N1 with the goal of informing the design of a larger trial powered to determine impact of statins on important outcomes. Methods/Design A multi-national, pilot randomized controlled trial (RCT of once daily enteral rosuvastatin versus matched placebo administered for 14 days for the treatment of critically ill patients with suspected, probable or confirmed H1N1 infection. We propose to randomize 80 critically ill adults with a moderate to high index of suspicion for H1N1 infection who require mechanical ventilation and have received antiviral therapy for ≤ 72 hours. Site investigators, research coordinators and clinical pharmacists will be blinded to treatment assignment. Only research pharmacy staff will be aware of treatment assignment. We propose several approaches to informed consent including a priori consent from the substitute decision maker (SDM, waived and deferred consent. The primary outcome of the CHAT trial is the proportion of eligible patients enrolled in the study. Secondary outcomes will evaluate adherence to

Study on the control mechanism of China aerospace enterprises' binary multinational operation

Institute of Scientific and Technical Information of China (English)

Wang Jian; Li Hanling; Wu Weiwei

2008-01-01

China's aerospace enterprises carry on the multinational operation and participate in the international competition and the international division of labor and cooperation positively.This article first analyzs China aerospace enterprises' binary multinational business control objective and constructes its model.Then the article analyzes the tangible and intangible control mechanism of China aerospace enterprises' binary multinational operation respectively.Finally,the article constructs the model of China aerospace enterprises' binary multinational operation mechanisms.

On Transfer Pricing: Conceptual Thoughts on the Nature of the Multinational Firm

OpenAIRE

Brem Markus; Tucha Thomas

2005-01-01

This paper deploys Transaction Cost Economics (TCE) to elaborate on the shortcomings of “mainstream” transfer pricing in multinational firms. Departing from the notion that multinationals increasingly (re-)organize their business along multinational value chains irrespective of jurisdictional borders, the paper discusses the nature of the multinational firm and the problem of choosing the right intra-group (transfer) price. The mainstream transfer pricing approach derived from the Arm´s Lengt...

Multinational/regional repository - an illusion or solution

International Nuclear Information System (INIS)

Mele, I.

2006-01-01

The concept and current status of multinational and regional repositories are presented in the paper. Particular emphasis is given to the results and findings of the recent EU project SAPIERR, investigating the feasibility of regional repository concepts in Europe. Prospects for further development of multinational repositories are also brought forward and the impact and potential benefits of this approach to our national disposal programme are discussed as well. (author)

PERAN OECD DALAM MEMINIMALKAN UPAYA TAX AGRESIVENESS PADA PERUSAHAAN MULTINATIONALITY

Directory of Open Access Journals (Sweden)

Hanindia Hajjar Damayanti

2017-04-01

Full Text Available Abstract: OECD's Role in Minimizing Tax Aggressiveness Efforts at Multinationality Companies. This paper aims to prove the relation between multinationality transaction of tax heaven countries and the tax investigation toward the tax aggressiveness. This research is done by quantitative approach upon the companies registered in BEI for 2010-2014 periods. The findings denote the tax heaven countries have no effort to conduct the tax aggressiveness on which the multinationality negatively has no effect since the occurrence in the OECD Transfer Pricing Guidelines as the guideline for both the taxing authority and the multinational companies in accomplishing the transfer pricing matter. In contrary, the investigation does not influence the tax aggressiveness.

Vertically Integrated Multinationals and Productivity Spillovers

DEFF Research Database (Denmark)

Clementi, Federico; Bergmann, Friedrich

are not automatic. In this paper, we study how these externalities are affected by the strategy of vertical integration of foreign multinationals. Our analysis, based on firm-level data of European manufacturing companies, shows that local firms perceive weaker backward spillovers if client foreign affiliates...... are vertically integrated in their industry. The spillovers that arise from the activity of companies that do not invest in the domestic firms’ industry are 2.6 to 5 times stronger than the ones than come from affiliates of multinationals that invest in the industry of local firms....

Ethics in international business: multinational approaches to child labor

NARCIS (Netherlands)

Kolk, A.; van Tulder, R.J.M.

2004-01-01

How do multinationals address conflicting norms and expectations? This article focuses on corporate codes of ethics in the area of child labor as possible expressions of Strategic International Human Resource Management. It analyses whether fifty leading multinational adopt universal ethical norms

AN INVESTIGATION INTO MEDIUM-SIZED MULTINATIONAL ENTERPRISES

Directory of Open Access Journals (Sweden)

Daniele Schilirò

2013-09-01

Full Text Available The paper provides an investigation of medium-sized Italian industrial enterprises that have become multinational companies. It concetrates on the set of medium and medium-large enterprises who seem to grow more in foreign markets, either through exports or through foreign direct investment. The work also offers a descriptive empirical picture of the performance of medium-sized Italian multinationals, which is compared with the performance of large corporations. From this analysis, which is based on several data sources, it is possible to outline a profile regarding the medium-size italian multinational enterprises; the aim is to understand the complex strategy towards internationalization of these companies, where the dimension of production is important and, therefore, innovation has a key role. Also the commercial dimension is crucial, because it leads to point to the direct supervision of foreign markets and to look very carefully at the customers, offering them a wide range of services. Finally, the paper highlights some critical issues that the medium sized multinational enterprises have to face for competing: namely, the stagnant productivity, the high taxation, the insufficient institutional support for internationalization, the bureaucracy and its high costs, the lack of skilled human capital available in the labor market due to inadequate policy training.

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

2014-01-01

The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...... multinationals leads to a reduction in R&D activity in the country. We use unique and rich firm level data for the Swedish manufacturing sector and micro-econometric estimation strategies in order to control for the potential endogeneity of the acquisition decision. Overall, our results give no support...... to the fears that foreign acquisition of domestic firms lead to a relocation of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic MNEs and non-MNEs....

The Performance and Risk Management Implications of Multinationality

DEFF Research Database (Denmark)

Juul Andersen, Torben

Multinational enterprise in control of dispersed overseas resources and capabilities has been linked to strategic flexibility that allows the firm to take advantage of opportunities and manage exposures imposed by changing environmental conditions. This paper analyzes the implied performance...... and risk management effects in a comprehensive sample of public firms and finds supportive evidence for the proposition that multinationality can enhance performance across industries. However, the ability to exploit upside potential and avoid downside risk is industry specific. The positive effects...... of multinationality are found particularly pronounced among firms operating in knowledge intensive service industries while firms in capital-intensive primary industries display the inverse relationships. Keywords: Strategic flexibility, Real options, Risk management...

Cultural Specifics of Management in Multinational Companies

OpenAIRE

Křečková Kroupová, Zuzana

2002-01-01

Nowadays the world is becoming increasingly economically connected, and cultural diversity of employees is gaining importance as a crucial competitive advantage. Cross-cultural communication ability is becoming a key management skill in multinational firms and is equally important for other employees who are exposed to other cultures in the workplace. This work mainly focuses on cultural specifics of management in multinational firms. The goal of this thesis is to discover how different natio...

FIRMS’ TRANSNATIONALIZATION. EVOLUTION OF MULTINATIONAL GROUPS OPERATING IN ROMANIA

Directory of Open Access Journals (Sweden)

Carmen NISTOR

2014-11-01

Full Text Available International business development is a complex phenomenon, characterized by a particularly dynamic due both to external and internal factors of the company and the need to foreshadow future directions in the development of the economic, social, political framework. Taking into consideration the ways that a company can expand, this article aims to analyse the evolution of multinational corporations operating in Romania in 2007-2012. Using data provided by The National Institute of Statistics (NIS, we focus on the multinationals groups that entered Romanian market in the period mentioned above. In this regard, we compared the multinational groups with the national ones, identifying the concentration of foreign capital by country. The results show that although has been recorded a significant variation of multinational groups in Romania, especially during the financial crisis period, the companies from Deutschland occupy first place by number of employees.

International taxation and multinational firm location decisions

OpenAIRE

Barrios Cobos, Salvador; Huizinga, Harry; Laeven, Luc; Nicodème, Gaëtan J.A.

2008-01-01

Using a large international firm-level data set, we estimate separate effects of host and parent country taxation on the location decisions of multinational firms. Both types of taxation are estimated to have a negative impact on the location of new foreign subsidiaries. In fact, the impact of parent country taxation is estimated to be relatively large, possibly reflecting its international discriminatory nature. For the cross-section of multinational firms, we find that parent firms tend to ...

[Economic analysis of multinational clinical trials in oncology].

Science.gov (United States)

Lejeune, Catherine; Lueza, Béranger; Bonastre, Julia

2018-02-01

In oncology, as in other fields of medicine, international multicentre clinical trials came into being so as to include a sufficient number of subjects to investigate a clinical situation. The existence of tight budgetary constraints and the desire to make the best use of the resources available have resulted in the development of economic evaluations associated with these trials, which, thanks to their level of evidence and their size, provide particularly relevant material. Nonetheless, economic evaluations alongside international clinical trials raise specific questions of methodology with regard to both the design and the analysis of the results. Indeed, the costs of goods and services consumed, the types and quantities of resources, and medical practices vary from one country to another and within an individual country. Economic data from the different countries involved must be available so as to study and to take into account this variability, and appropriate techniques for cost estimations and analysis must be implemented to aggregate the results from several countries. From a review of the literature, the aim of this work was to provide an overview of the specific methodological features of economic evaluations alongside international clinical trials: analysis of efficacy data from several countries, collection of resources and real costs, methods to establish the monetary value of resources, methods to aggregate results accounting for the trial effect. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Multinational Corporations and Stock Price Crash Risk

Directory of Open Access Journals (Sweden)

Anthony May

2016-10-01

Full Text Available A nascent literature in finance and accounting on tail risk in individual stock returns concludes that bad news hoarding by corporate managers engenders sudden, extreme crashes in a firm’s stock price when the bad news is eventually made public. This literature finds that firm-specific crash risk is higher among firms with more severe asymmetric information and agency problems. A hitherto disjointed literature spanning the fields of international business, finance, and accounting suggests that geographic dispersion in a firm’s operations, and especially dispersion across different countries, gives rise to organizational complexities and greater costs of monitoring that can exacerbate asymmetric information and agency problems. Motivated by the confluence of arguments and findings from these two strands of literature, this paper examines whether stock price crash risk is higher among multinational firms than domestic firms. Using a large sample of U.S. headquartered firms during 1987-2011, we find robust evidence that multinational firms are significantly more likely to crash than domestic firms. Moreover, we show that the difference in crash risk between multinational and domestic firms is most acute among firms with weaker corporate governance mechanisms, including weaker shareholder rights, less independent boards, and less stable institutional ownership. Our analysis indicates that stronger monitoring from each of these three governance mechanisms significantly attenuates the positive relation between crash risk and multinationality. Our findings are robust to the use of alternative measures of crash risk and to controlling for known determinants of crash risk identified in prior studies. Our study offers new insights that should hold value for scholars and market participants interested in understanding the implications of heighted agency problems that multinational firms are likely to encounter and scholars and market participants

Internal capital markets and lending by multinational bank subsidiaries

NARCIS (Netherlands)

De Haas, Ralph; van Lelyveld, Iman

We use new panel data on the intra-group ownership structure and the balance sheets of 45 of the largest multinational bank holdings to analyze what determines the credit growth of their subsidiaries. We find evidence for the existence of internal capital markets through which multinational banks

Consulting-Research Froblems with German and American Multinational Firms.

Science.gov (United States)

Hildebrandt, Herbert W.

International researchers need to be aware of international problems and multinational managerial codes when they work with worldwide organizations. This paper develops the premise that consulting with German multinational companies is more complex than consulting with or researching for American firms. Discussion focuses on the following three…

Quality of life and growth after childhood craniopharyngioma: results of the multinational trial KRANIOPHARYNGEOM 2007.

Science.gov (United States)

Heinks, Kerstin; Boekhoff, Svenja; Hoffmann, Anika; Warmuth-Metz, Monika; Eveslage, Maria; Peng, Junxiang; Calaminus, Gabriele; Müller, Hermann L

2018-02-01

Quality of life (QoL) after childhood-onset craniopharyngioma (CP) is frequently impaired due to tumor and/or treatment-related factors such as endocrine deficits and hypothalamic involvement/lesions. In a multinational trial, we prospectively analyzed parental and self-assessment of CP patient QoL at 3 months, 1 and 3 years after CP diagnosis related to growth hormone (GH) substitution. 47 of 194 CP recruited between 2007 and 2015 in KRANIOPHARYNGEOM 2007 were analyzed for QoL 1 and 3 years after CP diagnosis. QoL was assessed by Pediatric Quality of Life (PEDQOL) questionnaire and PEDQOL scores of parental and self-assessed QoL during 3 years follow-up after CP diagnosis were analyzed. Parents estimated QoL of their children worse than patients did themselves. GH substitution had no relevant effect on short-term weight and height development. CP patients GH-treated at 3 years follow-up presented at baseline (1 year after diagnosis, before GH substitution) with reduced self-assessed QoL when compared with GH non-treated CP. QoL stabilized during 1-3 years of follow-up in GH-treated patients, whereas non GH-treated patients experienced decreases in autonomy (p = 0.03), cognition (p = 0.01), and physical function (p = 0.04). Parents assess QoL in CP survivors worse than their children. GH substitution should be considered as a therapeutic option to ameliorate imminent impairments of QoL after CP.

Funding Costs and Loan Pricing by Multinational Bank Affiliates

Czech Academy of Sciences Publication Activity Database

Derviz, Alexis

2009-01-01

Roč. 9, č. 9 (2009), s. 1-48 ISSN 1803-7070 Institutional research plan: CEZ:AV0Z10750506 Keywords : multinational banks * bank loan pricing * internal capital market Subject RIV: AH - Economics http://library.utia.cas.cz/separaty/2010/E/derviz- funding costs and loan pricing by multinational bank affiliates.pdf

THE EXPANSION OF MULTINATIONAL COMPANIES GLOBALLY

Directory of Open Access Journals (Sweden)

DUDUIALĂ POPESCU LORENA

2017-12-01

Full Text Available The multinational firms now have a very important role to play in all countries' economies and international economic relations, turning into an increasingly important issue for governments. Through foreign direct investment, these firms can bring substantial gains to both home and host states by contributing to the efficient use of capital, technology and human resources across countries, and thus can play an important role in the development of economic prosperity and social issues. So the common goal of all countries is to stimulate positive contributions by which multinational firms can make economic and social progress and reduce or solve the difficulties that may arise from their operations.

MULTINATIONAL COMPANIES AND THEIR ATITUDE TOWARDS UNION ACTIVITY

OpenAIRE

Maria Cristina BÃLÃNEASA

2013-01-01

The intensification of the global economic activity has generated changes in working relations. The intensification of the activities within multinational companies has determined greater employment flexibility, but also a lower collective bargaining power of the employees, because the multinationals attempted to weaken the power of trade unions. The purpose of this paper is precisely to identify the attitude of these companies towards trade union activity and the reaction of labour organizat...

Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular disease and a low HDL-cholesterol

NARCIS (Netherlands)

Bergheanu, S. C.; van Tol, A.; Dallinga-Thie, G. M.; Liem, A.; Dunselman, P. H. J.; Van Der Bom, J. G.; Jukema, J. W.

Objective: Paraoxonase-1 (PON-1) is a highdensity lipoprotein (HDL) associated enzyme involved in the protective mechanisms of HDL. Our aim was to compare the effect of treatment with rosuvastatin and atorvastatin on serum PON-1 activity. Methods: We performed a prespecif ied prospective study in 68

Effect of intensive lipid-lowering treatment compared to moderate lipid-lowering treatment with rosuvastatin on endothelial function in high risk patients

DEFF Research Database (Denmark)

Egede, Rasmus; Jensen, Lisette Okkels; Hansen, Henrik Steen

2011-01-01

on the endothelial function evaluated with endothelium-dependent and endothelium-independent flow-mediated dilatation (FMD). METHODS: 87 Statin-naive patients with ST-segment elevation myocardial infarction (STEMI) were randomized to 5mg or 40mg rosuvastatin. The FMD was assessed at baseline, 6months and after 12...

Who Gets to Lead the Multinational Team?

DEFF Research Database (Denmark)

Paunova, Minna

2017-01-01

of their core self-evaluations. A study of over 230 individuals from 46 nationalities working in 36 self-managing teams generally supports the expected main and moderation effects. Individual core self-evaluations enhance an otherwise weak effect of English proficiency, but compensate for low levels of national......This article examines the emergence of informal leadership in multinational teams. Building on and extending status characteristics theory, the article proposes and tests a model that describes how global inequalities reproduce in multinational teams, and accounts for who gets to lead these teams...

The Transfer of Organisational Culture in Multinational Companies

OpenAIRE

Donmez, Ozlem

2007-01-01

The business world started to integrate internationally; therefore, it is likely to say that the multinational companies have become one of the key actors in international business. Since the multinational companies operate in many countries simultaneously; they face to multicultural challenges. The organisational culture is also influenced by the cultural diversity. It is possible to state that the transfer of the organisational culture is essential for the creation of the compatibility in t...

Effect of rosuvastatin versus atorvastatin treatment on paraoxonase-1 activity in men with established cardiovascular disease and a low HDL-cholesterol

NARCIS (Netherlands)

Bergheanu, S. C.; van Tol, A.; Dallinga-Thie, G. M.; Liem, A.; Dunselman, P. H. J.; van der Bom, J. G.; Jukema, J. W.

2007-01-01

Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL) associated enzyme involved in the protective mechanisms of HDL. Our aim was to compare the effect of treatment with rosuvastatin and atorvastatin on serum PON-1 activity. We performed a prespecified prospective study in 68 patients, part of a

Establishing a Communication Link between Multinational Companies and Their Subsidiaries.

Science.gov (United States)

Rao, Hema; Golen, Steven

A key characteristic of multinational companies is a worldwide perspective and orientation in managerial decision making. In its quest for international opportunities, a multinational company confronts many problems and uncertainties in evaluating and dealing with political, legal, economic, social, cultural, and governmental policy variables and…

Lending behavior of multinational bank affiliates

Directory of Open Access Journals (Sweden)

Alexis Derviz

2011-03-01

Full Text Available We study the parent influence on lending by affiliates of a multinational bank. In the proposed theoretical model, local lending is influenced by shareholder-affiliate manager delegation and precautionary motives. The outcome is either contagion (the loan volume in the affiliate follows the direction of the parent bank country shock or performance-based reallocation of funds (substitution, depending on the degree of manager delegation in the affiliate and the liquidity-sensitivity in theparent bank. Empirical investigation, deliberately conducted on a sample not covering the latest financial crisis, shows that also in “normal” times, multinational banks that are likely to delegate lending decisions or be more liquidity-sensitive are more inclined towards contagionist behavior.

Unravelling learning within multinational corporations

NARCIS (Netherlands)

Saka-Helmhout, Ayse

This article explores the impact of institutional variation on the extent to which subsidiary firms learn from multinational corporations. Learning is conceptualized here as consisting of two aspects: knowledge flow and reinforcement of or change in routines to incorporate the behaviourist

CRM System Implementation in a Multinational Enterprise

Science.gov (United States)

Mishra, Alok; Mishra, Deepti

The concept of customer relationship management (CRM) resonates with managers in today's competitive economy. As more and more organizations realize the significance of becoming customer-centric in today's competitive era, they embrace CRM as a core business strategy. CRM an integration of information technology and relationship marketing provides the infrastructure that facilitates long-term relationship building with customers at an enterprise-wide level. Successful CRM implementation is a complex, expensive and rarely technical projects. This paper presents the successful implementation of CRM in a multinational organization. This study will facilitate in understanding transition, constraints and implementation of CRM in multinational enterprises.

Foreign acquisitions, domestic multinationals, and R&D

DEFF Research Database (Denmark)

Bandick, Roger; Görg, Holger; Karpaty, Patrik

endogeneity of the acquisition dummy.  Overall, our results give no support to the fears that foreign acquisition of domestic firms lead to a brain drain of R&D activity in Swedish MNEs. Rather, this paper finds robust evidence that foreign acquisitions lead to increasing R&D intensity in acquired domestic......The aim of this paper is to evaluate the causal effect of foreign acquisition on R&D intensity in targeted domestic firms. We are able to distinguish domestic multinationals and non-multinationals, which allows us to investigate the fear that the change in ownership of domestic to foreign...

THE AMAZING UNIVERSE OF RUSSIAN MULTINATIONALS: NEW INSIGHTS

Directory of Open Access Journals (Sweden)

CODRUŢA DURA

2013-12-01

Full Text Available Over the past few years, large multinational companies originating from Russia have shown outstanding performances alongside their road from regional dominance to global leaders. Taking stock of recent approaches in the literature and statistical data released by well-known international organizations, our papers aims to provide some new insights from the amazing universe of Russian multinationals, following the 2008-2009 global economic crisis. The list of the largest multinationals from Russia shows that corporations from oil & gas and metallurgical sector are prevailing, as a consequence of the resource – based character of the Russian economy. Although Russian giants represents a quite heterogeneous class of companies, they do share several common features such as their propel mechanism of expansion on the global business stage (leveraged by the resource-based nature of their home economy, their tendency to invest in the neighboring countries (like Commonwealth of Independent States or East European countries, their modes of entry (through brownfield projects etc.

Emerging Multinational Companies and Strategic Fit

DEFF Research Database (Denmark)

Gammeltoft, Peter; Filatotchev, Igor; Hobdari, Bersant

2012-01-01

There is an increasing awareness in international business that institutional factors need to be better incorporated into the understanding of international investments decisions of multinational companies. This applies equally to outward foreign direct investment by emerging economy firms...... has been suggested in terms of integrating various theoretical frameworks however and developing a more holistic understanding of these new investment flows. In this Editorial we propose that outward FDI from emerging economies can be better understood by analyzing them within a broad institutional...... which considers flows of outward investment from emerging economies as framed by institutional pressures at the firm level towards achieving fit between the environment, strategies, structures, resources and practices of the firm. For the multinational firm this fit must be attained along multiple...

Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein

Czech Academy of Sciences Publication Activity Database

Šilhavý, Jan; Zídek, Václav; Landa, Vladimír; Šimáková, Miroslava; Mlejnek, Petr; Oliyarnyk, O.; Malínská, H.; Kazdová, L.; Mancini, M.; Pravenec, Michal

2015-01-01

Roč. 64, č. 3 (2015), s. 295-301 ISSN 0862-8408 R&D Projects: GA MŠk(CZ) LH11049; GA MŠk(CZ) LL1204; GA MZd(CZ) NT14325; GA ČR(CZ) GB14-36804G Institutional support: RVO:67985823 Keywords : rosuvastatin * kidney damage * CRP * transgenic * spontaneously hypertensive rat Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.643, year: 2015

Multinational Corporations, FDI and the East Asian Economic Integration

OpenAIRE

Tzu-Han YANG; Deng-Shing HUANG

2011-01-01

The phenomenon of fast-growing business activities of multinational corporations around the world has generated much interest in understanding its implications for the development of the world economy as well as the relationships among national economies. By analyzing the world's top 2000 firms published by Forbes Magazine (the Forbes Global 2000), this article first investigates the contents and structural evolution of these giant multinational firms and their relationship with national fore...

Multinational corporations and corporate social responsibility in the peace building in Colombia

OpenAIRE

Jiménez Peña, Gabriel

2014-01-01

This paper focuses on the role of the multinational corporations in the Colombian peace process. First a theoretical frame work is built which aims to shed light on the significance of multinationals in this process. The study then presents the specific Colombian experience with relation to the role of multinationals in the peace process. The penultimate section deals with the relation between peace, corporate social responsibility, and the UN Global Compact. Finally it offers a conclusion wi...

Multinationals and corporate social responsibility

NARCIS (Netherlands)

Kolk, A.

2010-01-01

This paper aims to shed some more light on the current debate related to corporate social responsibility (CSR), specifically considering multinational enterprises (MNEs) and the complexities they face when dealing with international issues and a range of stakeholders. It discusses notions of CSR in

Orchestration of Globally Distributed Knowledge for Innovation in Multinational Companies

DEFF Research Database (Denmark)

Sajadirad, Solmaz; Lassen, Astrid Heidemann

Conducting a multiple-case study in five companies from Danish industry, this paper explores how multinational companies orchestrate knowledge from their globally distributed subsidiaries for innovation. Comparisons of knowledge orchestration within headquarter and subsidiaries for improvement...... and innovation show that a combination of the dynamic use of inter-firm objects and a well-established knowledge orchestration process underlies knowledge orchestration for innovation in multinational companies, as it advances headquarters’ abilities to effectively acquire, evaluate, disseminate, and utilize...... globally distributed knowledge. This study contributes to the understanding of knowledge orchestration between headquarter and distributed subsidiaries in multinational companies and how it is related to innovation. Specifically, this paper has important implications regarding the use of inter-firm objects...

An Exploratory Investigation of Locally Constituted Challenges to Communication Management in Multinational Teams

DEFF Research Database (Denmark)

Lauring, Jakob; Jonassson, Charlotte

2008-01-01

It has been argued that multinational teams create a number of competitive advantages when used strategically. However, multinational teams are not always successful, and a number of studies indicate that communication between team members may be the main obstacle. The purpose of this article...... is to investigate communication problems in organizations consisting of multinational teams. It is argued that researchers should not only look for differences in national culture when analyzing barriers to the communication flow. Challenges to communication may also develop in the locally constituted...... organizational culture. This is illustrated by an ethnographic field study in a multinational department of a Danish organization....

The Effects of Organization Design on Media Richness in Multinational Enterprises.

Science.gov (United States)

Whitfield, J. Michael; And Others

1996-01-01

Examines effects of two organizational design parameters, divisionalization and centralization, on the media richness choices of Chief Executive Officers (CEOs) of multinational enterprises in obtaining information from foreign subsidiaries on strategic issues. Samples 86 US multinationals; finds formal divisional structure affects CEOs' use of…

Testing the Link Between Multinationality and the Return on Foreign Assets

NARCIS (Netherlands)

G.S. Yip (George); A. Kudina; A.M. Rugman (Alan)

2009-01-01

textabstractA large and robust emperical literature demonstrates that there is a strong relationship between the performance of a multinational enterprise (MNE) and its degree of multinationality. We develop a new metric to capture the return on foreign assets (ROFA), which we use as an alternative

Quality of life in infants and children with atopic dermatitis: Addressing issues of differential item functioning across countries in multinational clinical trials

Directory of Open Access Journals (Sweden)

Tennant Alan

2007-07-01

Full Text Available Abstract Background A previous study had identified 45 items assessing the impact of atopic dermatitis (AD on the whole family. From these it was intended to develop two separate scales, one assessing impact on carers and the other determining the effect on the child. Methods The 45 items were included in three clinical trials designed to test the efficacy of a new topical treatment (pimecrolimus, Elidel cream 1% in the treatment of AD in infants and children and in validation studies in the UK, US, Germany, France and the Netherlands. Rasch analyses were undertaken to determine whether an internationally valid, unidimensional scale could be developed that would inform on the direct impact of AD on the child. Results Rasch analyses applied to the data from the trials indicated that the draft measure consisted of two scales, one assessing the QoL of the carer and the other (consisting of 12 items measuring the impact of AD on the child. Three of the 12 potential items failed to fit the measurement model in Europe and five in the US. In addition, four items exhibiting differential item functioning (DIF by country were identified. After removing the misfitting items and controlling for DIF it was possible to derive a scale; The Childhood Impact of Atopic Dermatitis (CIAD with good item fit for each trial analysis. Analysis of the validation data from each of the different countries confirmed that the CIAD had adequate internal consistency, reproducibility and construct validity. The CIAD demonstrated the benefits of treatment with Elidel over placebo in the European trial. A similar (non-significant trend was found for the US trials. Conclusion The study represents a novel method of dealing with the problem of DIF associated with different cultures. Such problems are likely to arise in any multinational study involving patient-reported outcome measures, as items in the scales are likely to be valued differently in different cultures. However, where

Emerging Market Multinational Companies and Internationalization

DEFF Research Database (Denmark)

Nielsen, Bo Bernhard; Estrin, Saul; Nielsen, Sabina

2014-01-01

This paper furthers our understanding of the role of contextual conditions influencing internationalization of emerging market multinational companies (EMNCs). We use resource-based, industrial organization, and economic development theories to develop a multilevel theoretical framework...

Multinational Heterogenity and Knowledge Diffusion

NARCIS (Netherlands)

Smeets, R.A.L.M.

2009-01-01

During the past two decades, governments all around the world have spent millions of dollars to attract Foreign Direct Investment (FDI) of multinational companies. The large sums of money spent in this way have been justified on grounds of the alleged benefits of such activities in terms of domestic

Three Organizational Challenges for Multinational Enterprises

NARCIS (Netherlands)

Drogendijk, Rian; van Tulder, Rob; Verbeke, Alain; van Tulder, Rob; Verbeke, Alain; Drogendijk, Rian

2015-01-01

The rapidly changing and volatile institutional environments, within which Multinational Enterprises (MNEs) must operate, have put traditional organisational forms under pressure. Globalization and regionalism develop at the same time, whereas regulation facilitating Foreign Direct Investment (FDI)

Multinational Firms, National Culture, and Gender-Based Employment Discrimination

OpenAIRE

John Lawler

1995-01-01

Sex segregation in the workplace has been related to a variety of economic, institutional, and social factors. An issue that has only been explored to a limited extent is the role that multinational firms might play in promoting or inhibiting employment discrimination and sex segregation in developing countries. This study focuses on this issue within the context of Thailand, one of the world's most rapidly growing economies and a country with considerable investment by multinational firms. T...

Emerging Market Multinational Companies and Internationalization

DEFF Research Database (Denmark)

Estrin, Saul; Nielsen, Bo B.; Nielsen, Sabina

2017-01-01

We develop a multilevel theoretical framework for investigating the role of home country urbanization for emerging market multinational companies' (EMNCs) international expansion. We propose that more urbanized home environments directly increase EMNC's proclivity to internationalize and moderate...

LOCATION DECISIONS OF MULTINATIONAL COMPANIES IN ROMANIA

Directory of Open Access Journals (Sweden)

Lucia P. BLĂJUȚ

2016-07-01

Full Text Available This paper investigates the location decisions of foreign direct investments by the most important global multinational companies in Romania. The study covers the top 100 multinational companies, according to Fortune and underline that all of them have the headquarters location in the United States. In particular, this analysis presents the distribution of global companies based on the main industry and major economic sectors. The first company, from the rank 100, that invests in our country is Exxon Mobil (the number two on the list and has numerous projects in petroleum refining industry in many other countries, because energy sector is one of the most important ones in the global economy.

Globalization : Countries, Cities and Multinationals

NARCIS (Netherlands)

McCann, Philip; Acs, Zoltan J.

2011-01-01

McCann P. and Acs Z. J. Globalization: countries, cities and multinationals, Regional Studies. This paper explores the relationship between the size of a country, the size of its cities, and the importance of economies of scale in the modern era of globalization. In order to do this, it integrates

The Role of Multinational Companies in the Deployment of Foreign Direct Investments

Directory of Open Access Journals (Sweden)

Ion Botescu

2006-10-01

Full Text Available In the last decades multinational firms have become the leading actors of the international markets, including markets in developing countries. A multinational firm’s decision to open a branch or a subsidiary in another country, thus to invest abroad, is based on efficiency criteria, the obtained profit having a primordial aspect. We mustn’t forget the various advantages the host country befits of, here mentioning the transfer of technology. The unprecedented foreign amalgamation of multinational firms was brought on by the continuous liberalization of international commerce and investment fluxes.

Pharmacoligaclly Active: Clinical Trials and the Pharmaceuticals ...

African Journals Online (AJOL)

Multinational pharmaceutical companies ('pharmas') import and produce pharmaceuticals and also conduct clinical trials which are an important aspect of research and development (R&D). This may raise the question: Is South Africa a guinea pig for the pharmas? The Department of Trade and Industry National Industrial ...

Modular Structures in a Multinational Force Headquarters

National Research Council Canada - National Science Library

Stewart, K; Christie, M

2004-01-01

.... It is proposed that future Multinational Force (MNF) military headquarters (HQ) can achieve this flexibility through a modular organizational structure enabled by networked information management and communication technologies...

The Tax Sensitivity of Debt in Multinationals: A Review

OpenAIRE

Schjelderup, Guttorm

2015-01-01

The OECD in its BEPS action plan 4 addresses tax base erosion by profit shifting through the use of tax deductible interest payments. Their main concern is interest deductions between outbound and inbound investment by groups. Studies of multinational firms show that the tax sensitivity of debt is more modest than what one would expect given the incentives for profit shifting. The purpose of this paper is to review existing literature and to add new knowledge on multinational firm behavior th...

Implementation of a prospective pregnancy registry for antiretroviral based HIV prevention trials.

Science.gov (United States)

Mhlanga, Felix G; Noguchi, Lisa; Balkus, Jennifer E; Kabwigu, Samuel; Scheckter, Rachel; Piper, Jeanna; Watts, Heather; O'Rourke, Colin; Torjesen, Kristine; Brown, Elizabeth R; Hillier, Sharon L; Beigi, Richard

2018-02-01

Safety data on pregnancy and fetal outcomes among women in HIV prevention trials are urgently needed to inform use of effective antiretroviral agents for HIV prevention. We describe an effective, efficient, and novel method to prospectively collect perinatal safety data concurrent with on-going parent clinical trials. The Microbicide Trials Network (MTN)-016 study is a multinational prospective pregnancy exposure registry designed to capture pregnancy and neonatal outcomes. Studies currently contributing data to this registry included phase I and II safety trials with planned exposures to candidate HIV prevention agents, as well as phase IIB and III efficacy trials capturing data on pregnancy and infant outcomes following inadvertent fetal exposure during study participation. To date, participants from two phase I studies and two effectiveness trials have participated in MTN-016, resulting in 420 pregnant women and 381 infants enrolled. Infant retention has been high, with 329 of 381 (86%) infants completing the 12-month follow-up visit. In a research setting context, it is feasible to establish and implement a prospective, multinational HIV chemoprophylaxis pregnancy registry that will generate pregnancy exposure data in a robust fashion.

Leadership styles of nurse managers in a multinational environment.

Science.gov (United States)

Suliman, Wafika A

2009-01-01

This is a descriptive study conducted at a multinational working environment, where 1500 nurses representing 52 nationalities are employed. The study aimed at exploring the predominant leadership style of nurse managers through self-evaluation and staff nurses' evaluation and the impact of working in a multinational environment on their intention to stay or quit. The value lies in its focus on leadership styles in an environment where national diversity among managers, staff, and patients is very challenging. The study included 31 nurse managers and 118 staff nurses using Bass and Avolio's (1995) Multifactor Leadership Questionnaire. The results showed that nurse managers and staff nurses reported transformational leadership as predominant with significant difference in favor of nurse managers. Participants' nationality and intention to stay or quit affected their perception of transformational leadership as a predominant style. The implications highlight the need for senior nursing management to set effective retention strategies for transformational nurse managers who work at multinational environments.

Global Oligopolistic Competition and Multinational Corporations

DEFF Research Database (Denmark)

Hansen, Michael W.; Hoenen, Anne Kristin

2013-01-01

The contemporary International Business (IB) literature has ’forgotten’ a key insight of the early foreign direct investment (FDI) literature, namely that FDI often is driven by strategic interaction of multinational corporations (MNCs) in oligopolistic industries. Instead, the IB literature has ...

Helping Behavior in Multinational Executive Networks

DEFF Research Database (Denmark)

Mors, Marie Louise; Miller, Stewart; McDonald, Michael

This study develops a framework that draws upon the socio-psychology and network literatures to explain helping behavior in an executive’s multinational network. Focusing on executives' perceptions of willingness to help, we examine network structure (geographic and organizational boundaries), st...

Muscular fixing of the H.M.D.P. {sup 99m}Tc induced by a statin, rosuvastatin or crestor: clinical case; Fixation musculaire du HMDP Tc99m induite par une statine, la rosuvastatine ou Crestor: cas clinique

Energy Technology Data Exchange (ETDEWEB)

Bourahla, K.; Hassler, S.; Schneegans, O.; Gyen, L.N. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

2010-07-01

Myositis induced by statins in treatment for hypercholesterolemia is a special clinical entity that may be encountered during an exploration by bone scintigraphy. We present the case of a muscle fixing observed in bone scan in a patient treated with rosuvastatin (Crestor). Muscular extra bone fixing of hydroxy-methane diphosphonate (H.M.D.P.) {sup 99m}T in patients referred for staging of prostate carcinoma, patients sometimes also treated for high cholesterol may be iatrogenic due to taking statins. A simple history may then allow its identification, although it remains asymptomatic. (N.C.)

Coordinated vs. liberal market HRM: the impact of institutionalisation on multinational firms

NARCIS (Netherlands)

Farndale, E.; Brewster, C.; Poutsma, F.

2008-01-01

The impact of institutionalized contexts on the HRM activities of multinational firms has become a focus of increasing attention in recent literature. However, theories of how different types of business systems or market economies may influence HRM, and the impact of context on multinational

Technical, institutional and economic factors important for developing a multinational radioactive waste repository

International Nuclear Information System (INIS)

1998-06-01

Countries planning and implementing nuclear energy programmes should assume responsibility for the safe management and final disposal of radioactive waste from their programmes. However, there are countries whose radioactive waste volumes do not easily justify a national repository, and/or countries which do not have the resources or favorable natural conditions for waste disposal to dedicate to a national repository project. These countries would benefit from multinational co-operation for the disposal. Interest in the concept of a multinational repository for radioactive waste has been expressed by several Member States and the waste management community in the light of the potential benefit to the partner countries from the safety, technical and economic standpoints. However, such an approach involves many political and public acceptance issues and therefore a consensus among countries or regions concerned is a prerequisite. In this context, it was deemed appropriate that the IAEA access the technical, institutional, ethical and economic factors to be taken into account in the process of such consensus building. This report is intended to provide an assessment which can serve as a general basis for establishing a waste management policy and/or further assessing specific issues such as ownership and liability, institutional aspects and problems related to long term commitments. This report is divided into five sections where the first section gives background, objectives, scope and structure of the report. Section 2 discusses multinational repository concept in terms of needs and the role of a multinational repository, interaction between host and partner countries and formulation of a multinational repository. Section 3 identifies basic issues to be considered for establishing a multinational repository, and some specific issues relating to specific waste categories. Section 4 analyses potential benefits and challenges to be addresses in establishing a

Multinational fuel-cycle proposal for Latin America

Energy Technology Data Exchange (ETDEWEB)

Koehler, JR, W C

1980-03-01

The growth of energy demand projected for Latin America could be met by nuclear generated electricity if a multinational arrangement can be set up to meet the proliferation containment requirements and develop economies of scale that are satisfactory to all parties. A regionalized fuel-cycle center is outlined as a possible prototype for Latin America. A satisfactory operation there would indicate export feasibiltiy of the concept to other developing areas. The international strategies already in place have a heavy emphasis on weapons proliferation and have not been adequate. A multinational fuel-cycle concept with co-location technologies has the advantages of cost sharing, acceptable safeguards, and institutional barriers to proliferation. Security and cooperation between participants could be problems. 17 references. (DCK)

Taxing Multinationals 'Post-BEPS' - What's Next?

NARCIS (Netherlands)

M.F. de Wilde (Maarten)

2017-01-01

textabstractThe taxation of multinational companies has been attracting a great deal of attention in recent years. Com- pany tax planning and country tax competition have increasingly been questioned, by the general public, media, in politics and academia. Countries compete for investment, reducing

Overview on the Multinational Collaborative Waste Storage and Disposal Solutions

International Nuclear Information System (INIS)

MARGEANU, C.A.

2013-01-01

The main drivers for a Safe, Secure and Global Energy future become clear and unequivocal: Security of supply for energy sources, Low-carbon electricity generation and Extended nuclear power assuring economic nuclear energy production, safe nuclear facilities and materials, safe and secure radioactive waste management and public acceptance. Responsible use of nuclear power requires that – in addition to safety, security and environmental protection associated with NPPs operation – credible solutions to be developed for dealing with the radioactive waste produced and especially for a responsible long term radioactive waste management. The paper deals with the existing multinational initiative in nuclear fuel cycle and the technical documents sustaining the multinational/regional disposal approach. Meantime, the paper far-reaching goal is to highlight on: What is offering the multinational waste storage and disposal solutions in terms of improved nuclear security ‽

International expansion of Chinese multinationals: the new challenge of globalization

OpenAIRE

Quer, Diego; Claver-Cortés, Enrique; Rienda, Laura

2010-01-01

Over the last few years, a new generation of Chinese multinationals has set out to conquer global markets, featuring major international acquisitions that were unthinkable until very recently. This work seeks to analyze the nature of this emerging phenomenon, illustrating the reasons behind the international expansion of Chinese multinationals, the factors that facilitate and hinder this process, the entry modes that they use and the strategic implications for Western companies of their sudde...

Multinational uranium enrichment in the Middle East

International Nuclear Information System (INIS)

Ahmad, Ali; Salahieh, Sidra; Snyder, Ryan

2017-01-01

The Joint Comprehensive Plan of Action (JCPOA) agreed to by Iran and the P5+1 in July 2015 placed restrictions on Iran’s nuclear program while other Middle Eastern countries– Egypt, Jordan, Saudi Arabia, Turkey, and the United Arab Emirates–are planning to build their own nuclear power plants to meet increasing electricity demands. Although the JCPOA restricts Iran's uranium enrichment program for 10–15 years, Iran's neighbors may choose to develop their own national enrichment programs giving them a potential nuclear weapons capability. This paper argues that converting Iran's national enrichment program to a more proliferation-resistant multinational arrangement could offer significant economic benefits–reduced capital and operational costs–due to economies of scale and the utilization of more efficient enrichment technologies. In addition, the paper examines policy aspects related to financing, governance, and how multinational enrichment could fit into the political and security context of the Middle East. A multinational enrichment facility managed by regional and international partners would provide more assurance that it remains peaceful and could help build confidence between Iran and its neighbors to cooperate in managing other regional security challenges. - Highlights: • Freezing Iran's nuclear program is an opportunity to launch joint initiatives in ME. • A joint uranium enrichment program in the Middle East offers economic benefits. • Other benefits include improved nuclear security and transparency in the region.

The Multinational Logistics Joint Task Force (MLJTF)

National Research Council Canada - National Science Library

Higginbotham, Matthew T

2007-01-01

In this monograph, by analyzing the UN, NATO and the US Army's evolving Modular Logistics Doctrine, the author integrates the key areas from each doctrine into a multinational logistics joint task force (MLJTF) organization...

Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique

Directory of Open Access Journals (Sweden)

V. J. Kapure

2013-01-01

Full Text Available In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT. The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, liquid medications of water insoluble drugs in non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders. Formulated systems were assessed for precompression parameters like flow properties of liquisolid system, Fourior transform infra red spectra (FTIR analysis, X-ray powder diffraction (XRPD, differential scanning calorimetry (DSC, and post compression parameters like content uniformity, weight variation, hardness and friability, disintegration test, wetting time, in vitro dissolution studies, effect of dissolution volume on drug release rate, and estimation of fraction of molecularly dispersed drug in liquid medication. As liquisolid compacts demonstrated significantly higher drug release rates, we lead to conclusion that it could be a promising strategy in improving the dissolution of poor water soluble drugs and formulating immediate release solid dosage forms.

COMPETITIVE STRATEGY OF A FOREIGN MULTINATIONAL IN BRAZILIAN POULTRY PRODUCTION

OpenAIRE

Denise Barros de Azevedo; Liane Aparecida Aires da Silva Rengel; Guilherme Cunha Malafaia; Karim Marini Thomé

2012-01-01

This paper addresses the question of the strategies involved in the import process of cages for laying hens, directed at the multinational enterprise distribution center. Identifies the reasons why a multinational company invests in Brazil, specifically in the city of Araraquara, São Paulo, where it is implementing a distribution center (DC). Developing the study of the strategies involved in the process, according to the main issue of the work, it took place through the exploratory analysis ...

Effect of rosuvastatin dose-loading on serum sLox-1, hs-CRP, and postoperative prognosis in diabetic patients with acute coronary syndromes undergoing selected percutaneous coronary intervention (PCI).

Science.gov (United States)

Jiao, Yungen; Hu, Feng; Zhang, Zhengang; Gong, Kaizheng; Sun, Xiaoning; Li, Aihua; Liu, Naifeng

2015-01-01

To investigate the effect of rosuvastatin dose-loading on serum levels of lectin-like oxidized low-density lipoprotein receptor-1 (Lox-1) and high-sensitivity c-reactive protein (hs-CRP) and postoperative prognosis in patients with diabetes and non-ST segment elevation acute coronary syndromes (NSTEACS) undergoing selected percutaneous coronary intervention (PCI). A total of 72 patients with diabetes and NSTEACS were randomized to either the group treated with 20 mg rosuvastatin 12 hours prior to PCI with a second dose administered just before PCI (n = 33), or a control group treated with standard method according guideline (n = 39). Serum levels of sLox-1, hs-CRP, CK-MB, and cTnI were measured prior to PCI, and at 24 hours and 30 days after PCI. The 30-day incidence of major adverse cardiac events (MACE) was recorded in both groups. Compared to pre-PCI, serum levels of sLox-1 and hs-CRP of the two groups were increased at 24 hours after PCI (P PCI (P PCI, the levels of TC and LDL-C were not changed at 24 hours after PCI (P > 0.05) until 30 days after PCI (P PCI; the 30-day incidence of MACE occurred in 6.06% of patients in the loading-dose rosuvastatin-treated group and in 23.08% of patients in the control-treated group (P PCI, and also reduce the occurrence of MACE 30 days after PCI.

Acquisitions by Multinationals and Trade Liberalization

NARCIS (Netherlands)

Ray Chaudhuri, A.

2014-01-01

Abstract This paper develops a theoretical framework where a multinational firm (MNE) is allowed to acquire or sell a productive asset in multiple segmented asset markets. The asset is used to produce a final good which can be sold in multiple countries, with segmented product markets, undergoing

Multinational Taxation and R&D Investments

NARCIS (Netherlands)

de Waegenaere, A.; Sansing, R.C.; Wielhouwer, J.L.

2012-01-01

This study examines the effects of taxation on the incentives of multinational firms to develop and use intellectual property. We model optimal investment and production decisions by firms that engage in a patent race by making R&D investments. We investigate how taxes affect the level and

Multinational taxation and R&D investments

NARCIS (Netherlands)

De Waegenaere, A.M.B.; Sansing, R.; Wielhouwer, J.L.

2012-01-01

This study examines the effects of taxation on the incentives of multinational firms to develop and use intellectual property. We model optimal investment and production decisions by firms that engage in a patent race by making R&D investments. We investigate how taxes affect the level and

Domestic Multinationals and Foreign-Owned Firms in Italy: Evidence from Quantile Regression

Directory of Open Access Journals (Sweden)

Grasseni, Mara

2010-06-01

Full Text Available This paper investigates the performance differences across and within foreign-owned firms and domestic multinationals in Italy. Used for the empirical analysis are non-parametric tests based on the concept of first order stochastic dominance and quantile regression technique. The firm-level analysis distinguishes between foreign-owned firms of different nationalities and domestic MNEs according to the location of their FDI, and it focuses not only on productivity but also on differences in average wages, capital intensity, and financial and non-financial indicators, namely ROS, ROI and debt leverage. Overall, the results provide evidence of remarkable heterogeneity across and within multinationals. In particular, it seems not possible to identify a clear foreign advantage at least in terms of productivity, because foreign-owned firms do not outperform domestic multinationals. Interesting results are obtained when focusing on ROS and ROI, where the profitability gaps change as one moves from the bottom to the top of the conditional distribution. Domestic multinationals investing only in developed countries present higher ROS and ROI compared with the subgroups of foreign-owned firms, but only at the lower quantiles, while at the upper quantiles the advantage seems to favour foreign firms. Finally, in regard to domestic multinationals, there is strong evidence that those active only in less developed countries persistently exhibit the worst performances

Developing multinational radioactive waste repositories: Infrastructural framework and scenarios of cooperation

International Nuclear Information System (INIS)

2004-10-01

Currently the management of radioactive wastes centres on national strategies for collection, treatment, interim storage and disposal. This tendency to focus exclusively on national strategies reflects the fact that radioactive waste is a sensitive political issue, making cooperation among countries difficult. It is consistent with the accepted principle that a country that enjoys the benefit of nuclear energy, or the utilization of nuclear technology, should also take full responsibility for managing the generated radioactive waste. However, there are countries whose radioactive waste volumes do not easily justify a national repository, and/or countries that do not have the resources or favourable natural conditions for waste disposal to dedicate to a national repository project or would prefer to collaborate in shared initiatives because of their economic advantages. In such cases it may be appropriate for these countries to engage in a multinational collaborative effort to ensure that they have access to a common repository, in order that they can fulfil their responsibilities for their managing wastes safely. In response to requests from several Member States expressing an interest in multinational disposal options, the IAEA produced in 1998 a TECDOC outlining the important factors to be taken into account in the process of realizing such options. These factors include for example, technical (safety), institutional (legal, safeguards), economic (financial) socio-political (public acceptance) and ethical considerations. The present report reviews the work done in the previous study, taking into account developments since its publication as well as current activities in the field of multinational repositories. The report attempts to define the concepts involved in the creation of multinational repositories, to explore the likely scenarios, to examine the conditions for successful implementation, and to point out the benefits and challenges inherent to

Efficacy of Clopidogrel and Clinical Outcome When Clopidogrel Is Coadministered With Atorvastatin and Lansoprazole: A Prospective, Randomized, Controlled Trial.

Science.gov (United States)

Zhang, Jian-rong; Wang, Di-qing; Du, Jun; Qu, Guang-su; Du, Jian-lin; Deng, Song-bai; Liu, Ya-jie; Cai, Jin-xi; She, Qiang

2015-12-01

This prospective, randomized, nonblind, controlled trial evaluated the effects of clopidogrel on platelet function upon coadministration with atorvastatin and lansoprazole. One hundred four adult patients with non-ST-segment elevated acute coronary syndrome (NSTE-ACS) who underwent percutaneous coronary intervention (PCI) with drug-eluting stent implantation were included. All patients were treated with standard dual antiplatelet therapy (DAPT) plus rosuvastatin 10  mg daily after the operation. On the sixth day after PCI, patients were randomly divided into 4 groups, Group A: DAPT + atorvastatin 20  mg daily (a change from rosuvastatin to atorvastatin) + lansoprazole 30  mg daily, Group B: DAPT + atorvastatin 20  mg daily (a change from rosuvastatin to atorvastatin), Group C: DAPT + lansoprazole 30  mg daily (continuing to take rosuvastatin), Group D is the control group. Additional drugs were used according to the situation of patients. Platelet function and concentrations of platelet activation markers (granular membrane protein 140 (P-selectin), thromboxane B2 (TXB2), and human soluble cluster of differentiation 40 ligand (sCD40L)) were assessed before randomization and at 15- and 30-day follow-up visits. All patients were maintained on treatment for 6 months and observed for bleeding and ischemic events. A total of 104 patients were enrolled, 27 patients in group A, 26 patients in Group B/C, 25 patients in Group D separately, and all the patients were analyzed. There were no differences in platelet function and the levels of platelet activation markers (P-selectin, TXB2, and sCD40L) among or within the 4 groups at the 3 time points of interest (P > 0.05). In the subsequent 6 months, no significant bleeding events occurred, and 12 patients experienced ischemic events, these results were also not significantly different among the groups (P > 0.05). In patients diagnosed with NSTE-ACS who have had drug-eluting stent implantation

The Contribution of Local Environments to Competence Creation in Multinational Enterprises

DEFF Research Database (Denmark)

Andersson, Ulf; Dellestrand, Henrik; Pedersen, Torben

2014-01-01

This paper examines the competence development of subsidiaries in multinational enterprises. We analyze how local subsidiary environments affect the development of technological and business competencies among other units in the multinational enterprise. We test our predictions using data from 2......,107 foreign-owned subsidiaries located in seven European countries, by means of structural equation modeling — namely, LISREL. By bringing the local environment to the fore, we contribute to the literature on the emergence and determinants of firm-specific advantages. We link local subsidiary environments...... throughout the organization. Thus, we contribute to an enhanced understanding of location as a determinant of the creation of units of competence and centers of excellence within multinational enterprises. In other words, we demonstrate that country-specific advantages are beneficial for competence creation...

International taxation and multinational firm decisions

NARCIS (Netherlands)

Barrios, S.; Huizinga, H.P.; Laeven, L.; Nicodeme, G.

2012-01-01

Using a large international firm-level data set, we examine the separate effects of host and additional parent country taxation on the location decisions of multinational firms. Both types of taxation are estimated to have a negative impact on the location of new foreign subsidiaries. The impact of

Intercultural Communication Problems in Japanese Multinationals.

Science.gov (United States)

Nishiyama, Kazuo

Many large Japanese-owned multinational corporations have established successful subsidiaries in the United States, but distinct ethnic and cultural differences have caused communication problems between Japanese managers and American laborers and business people. Many top executives of the Japanese subsidiaries are sent to the United States on a…

The role of a multinational nuclear fuel fabrication supplier

International Nuclear Information System (INIS)

Beard, S.J.

1987-01-01

The author argues that international markets and multinational suppliers provide large benefits to utilities. It represents a long term commitment to the nuclear business that these companies will be able to supply nuclear technology on the long haul. The technology that is available around the world becomes available to everyone through the international markets and multinational suppliers. The increased experience base is seen as valuable in that errors that have been made or have not been made yet can be avoided through the transfer or experience. The security of supply is discussed as important to any utility that is operating a reactor

Framework and Challenges for Initiating Multinational Cooperation for the Development of a Radioactive Waste Repository

International Nuclear Information System (INIS)

2016-01-01

This publication is concerned with radioactive waste that requires geological disposal. It discusses the partnership arrangements necessary for the development of a multinational repository for disposal of this waste, but it also emphasizes that countries should not rely solely on a multinational solution and should in addition have coherent national plans for disposal (a dual track strategy). The publication focuses on multinational approaches based on the IAEA scenario for cooperation among countries in joint projects for the establishment of a shared geological repository. It describes the phased approach that would be needed, indicating the decision processes to be undertaken by partners in the multinational project, both within a national context and in the scope of the joint endeavour. It highlights a wide range of legal and institutional aspects, including the contractual obligations among partners, the economic and financial arrangements, liabilities, nuclear security, regulatory and legislative aspects, waste transportation arrangements, and social issues. It also addresses the uncertainties and risks involved in the implementation of a multinational repository

Knowledge Flows, Governance and the Multinational Enterprise

DEFF Research Database (Denmark)

Mahnke, Volker; Pedersen, Torben

This work contributes to the understanding of knowledge governance in the multinational corporation. Intra-firm and inter-firm processes of knowledge creation, sharing and exploitation have attracted increasingly managerial and scholarly interest. However the relation between particular knowledge...

The Army in Multinational Operations

Science.gov (United States)

2010-05-01

multinational commanders may be faced with nations refusing to perform assigned tasks. The term “national red card” using a soccer simile has been coined...human rights of individuals and groups must be respected. Impartiality. Humanitarian assistance must be provided without discrimination . Relief is...given without regard to nationality, political or ideological beliefs, race, religion, sex , or ethnicity, but only on the basis of the urgency of

Danish recommendations on treatment of ankylosing spondylitis and spondyloarthritis based on multinational project initiative

DEFF Research Database (Denmark)

Pedersen, Susanne Juhl; Madsen, Ole Rintek; Erlendsson, J.

2008-01-01

INTRODUCTION: The multinational initiative "3e Initiative in Rheumatology - Multi-national Recommendations for the Management of Ankylosing Spondylitis 2006-7" served the primary purpose of providing specific recommendations for the management of ankylosing spondylitis and spondyloarthritis...

Knowledge transfer and expatriation in multinational corporations

DEFF Research Database (Denmark)

Minbaeva, Dana; Michailova, Snejina

2004-01-01

Research on multinational corporation (MNC) knowledge transfer has argued continuously for the behavior of knowledge senders to be a determinant of knowledge transfer. Although the importance of disseminative capacity regarding knowledge transfer has been illustrated in numerous conceptual studies...

ERP systems in multi-national companies: support, maintenance and further development

OpenAIRE

Vymetal, Dominik; Matysek, Stanislav

2007-01-01

Multi-national companies introduce centralized or centrally administered ERP systems to cope with challenges of globalization. Introduction of such systems need careful planning. The planning should take not only the project and its deployment into consideration. Very important are the support and maintenance rules. The paper deals with rules used in case of a large multi-national company and resulting reaction of users in several subsidiaries in Central and Eastern Europe. The statistics obt...

A randomized trial of rosuvastatin in the prevention of venous thromboembolism

DEFF Research Database (Denmark)

Glynn, Robert J; Danielson, Eleanor; Fonseca, Francisco A H

2009-01-01

BACKGROUND: Controversy persists regarding the extent of shared pathways between arterial and venous thrombosis and whether treatments of known efficacy for one disease process have consistent benefits for the other. Observational studies have yielded variable estimates of the effect of statin...... therapy on the risk of venous thromboembolism, and evidence from randomized trials is lacking. METHODS: We randomly assigned 17,802 apparently healthy men and women with both low-density lipoprotein (LDL) cholesterol levels of less than 130 mg per deciliter (3.4 mmol per liter) and high-sensitivity C...

COMPETITIVE STRATEGY OF A FOREIGN MULTINATIONAL IN BRAZILIAN POULTRY PRODUCTION

Directory of Open Access Journals (Sweden)

Denise Barros de Azevedo

2012-05-01

Full Text Available This paper addresses the question of the strategies involved in the import process of cages for laying hens, directed at the multinational enterprise distribution center. Identifies the reasons why a multinational company invests in Brazil, specifically in the city of Araraquara, São Paulo, where it is implementing a distribution center (DC. Developing the study of the strategies involved in the process, according to the main issue of the work, it took place through the exploratory analysis of the current logistics process of the Company, identifying the strategies adopted and the advantages of the new process. In order to achieve the objectives, the study is based on the theoretical study of Porter's five competitive forces, SWOT analysis, generic strategies adopted to achieve return on investment and, based on issues such as import , logistics, warehousing and distribution center. The survey shows that deployment of the DC, the strategy involves the insertion in the national market, specifically in São Paulo that is the biggest market of laying hens in the country to gain competitive advantage, and the multinational also adopts the strategy generic differentiation, with regard to technology and product quality. Despite the high costs of construction and maintenance of the DC, they represent a barrier to market entry, have no financial risk for the multinational enterprise, since this deployment will also increase the demand for the product, allowing the return on invested capital.

Platelet reactivity in response to loading dose of atorvastatin or rosuvastatin in patients with stable coronary disease before percutaneous coronary intervention: The STATIPLAT randomized study.

Science.gov (United States)

Godino, Cosmo; Pavon, Anna Giulia; Mangieri, Antonio; Salerno, Anna; Cera, Michela; Monello, Alberto; Chieffo, Alaide; Magni, Valeria; Cappelletti, Alberto; Margonato, Alberto; Colombo, Antonio

2017-08-01

The acute effects of statin loading dose (LD) on platelet reactivity in patients with chronic stable angina (CSA) are not completely clear. We hypothesized that LDs of atorvastatin and rosuvastatin have different pharmacodynamic acute effects on platelet aggregability in CSA patients with baseline normal platelet reactivity while on dual antiplatelet therapy (DAPT). From September 2011 to February 2014, all consecutive CSA patients on chronic DAPT (aspirin and clopidogrel) were evaluated before elective percutaneous coronary intervention (PCI). An initial assessment of platelet reactivity in response to thrombin receptor agonist, ADP, and ASP (respectively, indicative of the response to clopidogrel and aspirin) was performed with impedance aggregometry. Patients with high platelet reactivity to ADP test (area under the curve >47) were excluded. The remaining patients were randomized into 3 treatment groups: Group A, atorvastatin LD 80 mg; Group B, rosuvastatin LD 40 mg; and Group C, no statin LD (control group). A second assessment of platelet reactivity was performed ≥12 hours after statin LD. 682 patients were screened and 145 were randomized into the 3 groups. At baseline and after statin LD, no significant difference was found in platelet reactivity in response to 3 different agonists between the 3 groups. Subgroup analysis showed that platelet reactivity to ADP test was significantly lower in patients chronically treated with low-dose statins (n = 94) compared with statin-naïve patients (n = 51; 15.32 ± 1.50 vs 18.59 ± 1.30; P = 0.007). Loading dose of atorvastatin (80 mg) or rosuvastatin (40 mg) did not induce significant variation in platelet reactivity in CSA patients with baseline reduced platelet reactivity as in chronic DAPT. Our data confirm that chronic concomitant treatment with low-dose statins and clopidogrel resulted in significantly lower platelet reactivity compared with clopidogrel alone. © 2017 Wiley Periodicals, Inc.

Employment Practices of Multinational Companies in Denmark

DEFF Research Database (Denmark)

Navrbjerg, Steen Erik; Minbaeva, Dana

Globaliseringen er en udfordring for såvel ledere som ansatte i multinationale selskaber. En analyse af ledere og medarbejderes relationer er afgørende for at forstå ledelse, forretningsforhold og arbejdsmarkedsrelationer i Danmark. Tilstedeværelsen af multinationale selskaber (Multinational Comp...

Shaping Regional Strategies of Multinational Corporations

DEFF Research Database (Denmark)

Gilbert, Dirk Ulrich; Heinicke, Patrick; Rasche, Andreas

This paper examines the factors that drive the success of multinational corporations (MNCs) in their pursuit of regional strategies. We develop a comprehensive regional success factor model to investigate the effects of regional management autonomy and regional product/service adaption...... management autonomy and regional product/service adaption are higly contingent upon contextual influences on MNCs....

Standard requirements for GCP-compliant data management in multinational clinical trials

DEFF Research Database (Denmark)

Ohmann, Christian; Kuchinke, Wolfgang; Canham, Steve

2011-01-01

A recent survey has shown that data management in clinical trials performed by academic trial units still faces many difficulties (e.g. heterogeneity of software products, deficits in quality management, limited human and financial resources and the complexity of running a local computer centre...

Risk Management Practices of Multinational and indigenous ...

African Journals Online (AJOL)

Construction projects' high uncertainty rates make them unattractive to non-risk takers. Construction companies are therefore necessarily risk takers, albeit, to varying degrees. This study made an inquiry into the risk management (RM) practices of multinational and indigenous construction companies (MCCs and ICCs, ...

Centralized vs. De-centralized Multinationals and Taxes

DEFF Research Database (Denmark)

Nielsen, Søren Bo; Raimondos-Møller, Pascalis; Schjelderup, Guttorm

2005-01-01

The paper examines how country tax differences affect a multinational enterprise's choice to centralize or de-centralize its decision structure. Within a simple model that emphasizes the multiple conflicting roles of transfer prices in MNEs - here, as a strategic pre-commitment device and a tax...

Corporate Social Responsibility of Multinational Oil Corporations to ...

African Journals Online (AJOL)

Corporate Social Responsibility of Multinational Oil Corporations to Host ... Exxon Mobil and Elf oil Nigeria Limited within their corporate-community relations strategy in the ... The paper concludes by exploring the implications for partnerships' ...

Multinational surveys for monitoring eHealth policy implementations

DEFF Research Database (Denmark)

Gilstad, Heidi; Faxvaag, Arild; Hyppönen, Hannele

2014-01-01

Development of multinational variables for monitoring eHealth policy implementations is a complex task and requires multidisciplinary, knowledgebased international collaboration. Experts in an interdisciplinary workshop identified useful data and pitfalls for comparative variable development...

Labour standards application among multinational and domestic firms in Ghana’s manufacturing sector

Directory of Open Access Journals (Sweden)

Dziedzom-Akorsu Angela

2011-01-01

Full Text Available This paper provides an empirical analysis of the labour standards application patterns and influences among multinational and domestic firms in Ghana. Discourses on labour standards application have continued to attract much interest in recent years. This is because globalization, in tandem with multinational corporations, has made the application of labour standards more challenging and ever more relevant. Yet competing viewpoints raised among social scientists on the subject are inconclusive and still on-going. While some are of the view that multinational companies (MNCs maintain higher labour standards than the domestic firms of their host countries, others concede that their standards are lower due to their exploitative tendencies. By means of a survey of 248 multinational and domestic firms in the manufacturing sector of Ghana, this paper concludes that there are a number of contingent factors that determine labour standards application, and so it is misleading to put all firms together and make blanket statements as to whether or not one group maintains higher labour standards than the other.

Functional Upgrading and Value Capture of Multinational Subsidiaries

DEFF Research Database (Denmark)

Burger, Anže; Jindra, Björn; Marek, Philipp

2018-01-01

survey-based business function indicators with longitudinal accounting data for a representative sample of multinational subsidiaries located in six Central and Eastern European countries (CEECs), we assess the impact of functional upgrading on foreign subsidiaries' value capture. The results provide......This paper investigates the relationship between the value capture of multinational subsidiaries and functional upgrading, which is defined as a diversification of employment from primary business functions to higher value adding activities such as ICT, R&D, marketing or logistics. By combining...... robust evidence that the breadth as well as the scope of functional upgrading induces an upward shift of subsidiaries' value added. The effect of functional upgrading is stronger in the earlier phases after entry of the foreign investor, while the long-term growth trend remains unaffected....

Multinational banks and development finance

OpenAIRE

Weller, Christian E.; Scher, Mark J.

1999-01-01

Financial market recommendations for less industrialized economies, particularly in the wake of the recent financial crises, have included a push for more international financial competition. The entry of multinational banks (MNBs) into developing economies is supposed to create more market discipline for domestic banks, thus making them more efficient, and enhancing financial stability. Using data from the BIS and the IMF, we look at the determinants of MNB presence, at MNB activities, and t...

A theoretical assessment of the empirical literature on the impact of multinationality on performance

NARCIS (Netherlands)

Hennart, J.M.A.

2011-01-01

I assess the theoretical basis for the existence of a relationship between the size of a firm's foreign footprint (its multinationality) and its performance. I argue that multinationality results from a firm's choice between coordinating internally the stages of its value chain and letting them be

A Cost-based Explanation of Gradual, Regional Internationalization of Multinationals on Social Networking Sites

DEFF Research Database (Denmark)

Pogrebnyakov, Nicolai

2017-01-01

of internationalization. Data on 5827 country pages of 240 multinational firms on Facebook, the most popular SNS today, is used. Creating a foreign country-specific Facebook page is considered the SNS equivalent of opening a physical subsidiary in that country. The data show that multinationals exhibit...

Expatriate training and support: How effective are multinational companies’ practices in Cyprus?

OpenAIRE

Hadjiyianni, Chara

2009-01-01

Most of the literature demonstrates that multinational companies do not adequately train and support expatriates prior to and during overseas assignments. If expatriates do not sufficiently adjust to host-country conditions, this can have detrimental effects on expatriate managers themselves, the assignment and the sending organisation. This study examines the effectiveness of expatriate training and support practices of multinational companies in Cyprus. The dissertation builds on three them...

'A question of balance': addressing the public health impacts of multinational enterprises in the OECD Guidelines for Multinational Enterprises.

Science.gov (United States)

Yang, Joshua S; McDaniel, Patricia A; Malone, Ruth E

2012-01-01

The global community is beginning to address non-communicable diseases, but how to increase the accountability of multinational enterprises (MNEs) for the health impacts of their products and practices remains unclear. We examine the Organization for Economic Cooperation and Development's (OECD) efforts to do so through voluntary MNE guidelines. We developed a historical case study of how the OECD Guidelines for Multinational Enterprises were developed and revised from 1973 to 2000 through an analysis of publicly available archived OECD and tobacco industry documents. The first edition of the Guidelines was a purely economic instrument. Outside pressures and a desire to ward off more stringent regulatory efforts resulted in the addition over time of guidelines related to the environment, consumer interests, sustainable development and human rights. Despite their voluntary nature, the Guidelines can play a role in efforts to help balance the interests of MNEs and public health by providing a starting point for efforts to create binding provisions addressing MNEs' contributions to disease burden or disease reduction.

US/UK Sensor-To-Shooter Multinational C4 Interoperability Study Force-On-Force Effectiveness Methodology

National Research Council Canada - National Science Library

Bailey, Timothy J

2000-01-01

.... This methodology has been successfully applied to Army, joint, and multinational studies. The latest of these studies, the US/UK Sensor-To-Shooter Multinational C4 Interoperability Study Force-On-Force Analysis, was an effort to measure the value...

Determinants of reverse knowledge transfer for emerging market multinationals: the role of complexity, autonomy and embeddedness

Directory of Open Access Journals (Sweden)

Franciane Freitas Silveira

Full Text Available Abstract Subsidiaries conduct innovation activities in foreign markets either to capture valuable knowledge that is necessary to adapt their products to local markets or to create valuable knowledge for headquarters. For emerging market multinationals, most studies have overlooked the determinants of successful reverse knowledge transfer from subsidiaries located in emerging and developed markets. This paper analyzed the responses of a survey administered to 78 Brazilian multinationals that own subsidiaries in developed and emerging markets. We found that knowledge complexity developed at the subsidiary, its autonomy and embeddedness in the foreign market determine the successful reverse knowledge transfer to headquarters of emerging market multinationals. This paper contributes to previous studies of reverse knowledge transfer by underlying the main drivers for emerging market multinationals.

Managing Human Resources in a Multinational Context

Science.gov (United States)

Sumetzberger, Walter

2005-01-01

Purpose: To develop more sensitivity for different patterns of human resource management in multinational companies. Design/methodology/approach: Systemic approach; the concepts and models are based on the evaluation of consulting projects in the field of human resource management. Findings: A concept of four typical varieties of human resource…

Multinational Subsidiary Performance: Evidence from the Ghanaian ...

African Journals Online (AJOL)

The study seeks to ascertain the factors that contribute to the performance of multinational subsidiary banks in Ghana. Using an unbalanced random effects panel regression estimation following the Hausman specification test, the study found that increasing bank size does not necessarily lead to performance. As it stands ...

Model of the naval base logistic interoperability within the multinational operations

Directory of Open Access Journals (Sweden)

Bohdan Pac

2011-12-01

Full Text Available The paper concerns the model of the naval base logistics interoperability within the multinational operations conducted at sea by NATO or EU nations. The model includes the set of logistic requirements that NATO and EU expect from the contributing nations within the area of the logistic support provided to the forces operating out of the home bases. Model may reflect the scheme configuration, the set of requirements and its mathematical description for the naval base supporting multinational forces within maritime operations.

Researchers', Regulators', and Sponsors' Views on Pediatric Clinical Trials: A Multinational Study.

Science.gov (United States)

Joseph, Pathma D; Craig, Jonathan C; Tong, Allison; Caldwell, Patrina H Y

2016-10-01

The last decade has seen dramatic changes in the regulatory landscape to support more trials involving children, but child-specific challenges and inequitable conduct across income regions persist. The goal of this study was to describe the attitudes and opinions of stakeholders toward trials in children, to inform additional strategies to promote more high-quality, relevant pediatric trials across the globe. Key informant semi-structured interviews were conducted with stakeholders (researchers, regulators, and sponsors) who were purposively sampled from low- to middle-income countries and high-income countries. The transcripts were thematically analyzed. Thirty-five stakeholders from 10 countries were interviewed. Five major themes were identified: addressing pervasive inequities (paucity of safety and efficacy data, knowledge disparities, volatile environment, double standards, contextual relevance, market-driven forces, industry sponsorship bias and prohibitive costs); contending with infrastructural barriers (resource constraints, dearth of pediatric trial expertise, and logistical complexities); navigating complex ethical and regulatory frameworks ("draconian" oversight, ambiguous requirements, exploitation, excessive paternalism and precariousness of coercion versus volunteerism); respecting uniqueness of children (pediatric research paradigms, child-appropriate approaches, and family-centered empowerment); and driving evidence-based child health (advocacy, opportunities, treatment access, best practices, and research prioritization). Stakeholders acknowledge that changes in the regulatory environment have encouraged more trials in children, but they contend that inequities and political, regulatory, and resource barriers continue to exist. Embedding trials as part of routine clinical care, addressing the unique needs of children, and streamlining regulatory approvals were suggested. Stakeholders recommended increasing international collaboration

Management Control Systems in Subsidiaries of Multinationals in the Emerging Market of Central Eastern Europe

NARCIS (Netherlands)

Gusc, J.S.; Bremmers, H.J.; Omta, S.W.F.

2005-01-01

Using transaction cost theory and the theory of multinational enterprise, this study examines the extent of the degree to which management of multinational companies can control over its subsidiaries' configuration and coordination abilities. Empirical results showed that the subsidiaries enjoyed a

The Impact of Headquarter and Subsidiary Locations on Multinationals' Effective Tax Rates

OpenAIRE

Kevin S. Markle; Douglas A. Shackelford

2013-01-01

We examine effective tax rates (ETRs) for 9,022 multinationals from 87 countries from 2006 to 2011. We find that, despite extensive investments in international tax avoidance, multinationals headquartered in Japan, the United States, and some high-tax European countries continue to face substantially higher worldwide taxes than their counterparts in havens and other less heavily taxed locations. Other findings include: (1) effective tax rates remained steady over the investigation period; (2)...

Business Communication Consulting and Research in Multinational Companies.

Science.gov (United States)

Hildebrandt, Herbert W.

1978-01-01

Describes three issues involved in communication research and consulting for multinational companies, particularly those in Germany: qualifications for doing international consulting and research, problems of American scholar-researchers in those firms, and suggestions for dealing with those issues. (JMF)

Human factors and technology environment in multinational project: problems and solutions

International Nuclear Information System (INIS)

Jardi Besa, X.; Munoz Cervantes, A.

2012-01-01

At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.

Small Nations in Multinational Operations and Armenian Perspectives

Science.gov (United States)

2014-12-12

assigned in different positions gain experience in working in multinational and multicultural environments. 25 Megan Hart, “Kansas National Guard...comes from various internet publications and printed materials provided by the online Combined Arms Research Library . Although there were not many

Democratizing the Multinational Corporation (MNC)

DEFF Research Database (Denmark)

Andersen, Torben Juul; Hallin, Carina Antonia

2017-01-01

insights that can be used strategically if management at headquarters is cognizant about its existence and able to collect this information. We introduce the notion of democratizing the strategic engagement of managers and employees at all levels and locations of the multinational corporation (MNC......) as an essential leadership paradigm. The implied interaction between slow central analytical reasoning at headquarters and updated insights from fast decentralized initiatives in local subsidiaries constitutes an effective dynamic responsive mechanism. This dynamic interaction implies that critical strategic...

APPROACHING COMPETITIVENESS AT THE LEVEL OF MULTINATIONAL COMPANIES

Directory of Open Access Journals (Sweden)

DORINA NIŢĂ

2011-01-01

Full Text Available The competitiveness of multinational corporations is a particularly complex concept due to the fact that at present this type of company represents economic entities which continue to develop in the context of the process of internationalization and the transition to the use of global strategies. Competitiveness is a competition between corporations for new positions on the markets. With regard to the competitiveness of multinational corporations, the most accurate description was given by Gilbert Abraham Frois who believed these businesses must think globally, but act locally. In the competitive global market, emphasis is laid on plus – the value given by the competitiveness of the human element, taking into account the fact that the human resource doesn’t run out, and its value doesn’t decrease over time, but on the contrary, its value increases on condition that it is rigorously managed and developed.

Multinational Enterprises and Social Capital as Location Factor

DEFF Research Database (Denmark)

Pedersen, Kurt; Svendsen, Gunnar L.H.; Svendsen, Gert Tinggaard

2013-01-01

across borders. We review the literature and identify a gap regarding social capital as a potential instrument for reducing the level of volatility. An existing stock of social capital may be advantageous not only to the host country but also to the MNE in the sense that optimal in-company resource......It is generally assumed that multinational enterprises (MNEs) are more volatile than local firms. From the viewpoint of host countries, the volatility of MNE subsidiaries is often seen as a problem. Therefore it becomes relevant to look for ways to reduce the volatility of multinational activity...... allocation and profits could be improved even further. Thus, the dominating theory of FDI (Foreign Direct Investment), the eclectic paradigm as developed by John Dunning, offers a relevant opportunity to fill a gap in the literature and include social capital in FDI decisions as a new location factor....

Institutional arrangements for a multinational reprocessing plant

International Nuclear Information System (INIS)

Smith, C.B.; Chayes, A.

1977-01-01

The paper lists some of the major issues that would have to be faced in negotiating the institutional structure of a multinational nuclear-fuel center. None of the organization problems is inherently insoluble. Difficulties are exacerbated by the large number of questions, their interrelations, and the complexity of the assumed structure. However, the assumptions posed the most difficult case. A reduction in membership and in the ambitious scope of the enterprise, at least at the outset, would greatly reduce the complexity of the organizational structure and the difficulty of negotiations. The analysis suggests that multinational fuel-cycle activities should start out more modestly, perhaps only with joint appraisal by a relatively few countries with existing geographic or economic connections. If operations are contemplated it would seem that the first step should be joint arrangements for spent-fuel storage, with the decision to go forward to more elaborate activities deferred. This approach would not only be simpler and permit the parties to gain experience working together, but it would have the virtue of delaying reprocessing until it was clear that there was a real need for it. Even on this reduced basis, the negotiating task would not be easy. The key, of course, to overcoming difficult technical problems of institutional structure is politial will--the genuine commitment of the participants to the aims and values of the enterprise. This suggests that any effort to cajole--not to say coerce--participation in a multinational fuel-cycle enterprise would be wholly misplaced. A reluctant partner would have available an infinitude of points and issues to create plausible, irritating, and ultimately defeating delay and complication in the negotiating process. Only assent freely given in the perception that the enterprise really serves the interest of the countries involved will be able to surmount the many institutional problems that will inevitably arise

Responsible tax as corporate social responsibility: the case of multinational enterprises and effective tax in India

NARCIS (Netherlands)

Muller, A.; Kolk, A.

2015-01-01

Anecdotal evidence often suggests that multinational enterprises (MNEs) operating in developing countries "exploit their multinationality" to avoid paying taxes to host governments. This article explores the concept of "responsible tax" as a corporate social responsibility (CSR) issue for MNEs,

Serving low-income markets : Rethinking multinational corporations' strategies

NARCIS (Netherlands)

Sadreghazi, S.; Duijsters, G.M.; Dolfsma, W.; Duysters, G.M.; Costa, I.

2009-01-01

The global economy is changing rapidly and multinational corporations (MNCs) are at the forefront of this transformation. This book provides novel and profound analyses of how MNCs and emerging economies are related, and how this relationship affects the dynamics of the global economy. In

Development of Barnwell as a multinational demonstration facility

International Nuclear Information System (INIS)

Colby, L.J. Jr.

1977-01-01

The author takes an existing private business venture (Barnwell) with its assets of facilities, personnel, technology and domestic business commitments (past, present, and future) and develops a role for it which will be compatible with the advancement of multinational reprocessing facilities under international control

Complying with the European Clinical Trials directive while surviving the administrative pressure

DEFF Research Database (Denmark)

Frandsen, Thomas Leth; Heyman, Mats; Abrahamsson, Jonas

2014-01-01

The European Clinical Trials Directive of 2004 has increased the amount of paper work and reduced the number of initiated clinical trials. Particularly multinational trials have been delayed. To meet this challenge we developed a novel, simplified, fast and easy strategy for on-line toxicity......-known serious, but rarer events with focus on changes in therapy introduced in the treatment protocol. This toxicity registration strategy was approved by the relevant regulatory authorities in all seven countries involved, as compliant within the EU directive of 2004. The centre compliance to registration...

Decision-making regarding restructuring in multinational enterprises.

OpenAIRE

Ghertman M

1986-01-01

ILO pub. Working paper, evaluation of three case studies of decision making regarding enterprise restructuring in multinational enterprises originating in Canada, the USA and Western Europe - examines the role of management attitude, business organization, capital resources and size of enterprise in determining subsidiary enterprise creation, enterprise takeover, plant shutdown, resource allocation, labour utilization, etc. Diagrams, organigrams, references, tables.

Decision-making in multinational enterprises: concepts and research approaches.

OpenAIRE

Ghertman M

1984-01-01

ILO pub. Working paper on decision making processes in multinational enterprises - gives definition, type and classification of decision making in large enterprises; outlines the centralization decentralization theory and the iterative process; notes research needs. Bibliography.

ATHEROSCLEROSIS: HOW TO START UP A "COUNT DOWN" CLOCK? WE DON'T KNOW, WE CAN NOT OR WE DO NOT WANT?

Directory of Open Access Journals (Sweden)

L. N. Malay

2011-01-01

Full Text Available Clinical cases of long-term use of rosuvastatin are presented with an estimation of its effect on the soft end (lipid profile and hard end (number of heart attacks, strokes, heart failure, hospitalization for cardiovascular causes points are given. The results of studies on rosuvastatin (ASTEROID, CORONA, METEOR, ORION, COSMOS are presented. Clinical guidelines on the management of patients with stable ischemic heart disease are considered on the example of COURAGE trial.

Lean Manufacturing Implementation for Multinational Companies with Production Subsidiary in Brazil: Development of A Roadmap

Directory of Open Access Journals (Sweden)

L. Goehnera,

2016-06-01

Full Text Available Foreign multinational companies with a production subsidiary in Brazil are in general recognized as high-level productive companies; however, their productivity potential is mostly not fully achieved. Lean Manufacturing (LM has been proved as a valuable aid to achieve competitiveness in the long run. Regarding the rising importance of successfully implementing LM at multinationals in Brazil and an apparent lack of discussion regarding LM in Brazil this paper aims to propose a comprehensive implementation roadmap, which enables a multinational on a basis of a systematic approach, to achieve an advanced sustainable LM system in a practical manner. The insights of literature and case studies are combined to develop the roadmap. The roadmap was developed so that both companies, those, which have not started yet their journey towards LM, as well as those that have taken already the first steps can use the roadmap. However, the roadmap was built on a broad empirical basis. It should be noticed that it is impossible to consider all factors influencing the LMI at multinationals operating in Brazil in a real world setting. As a result, the roadmap should not be regarded as a ready implementation plan, which has to be strictly followed. Instead, it should be seen as a guideline, which helps a multinational to develop its own, detailed and fitted plan for successfully implementing LM and establishing a learning organization.

CULTURAL DIVERSITY AND HUMAN RESOURCE MANAGEMENT IN MULTINATIONAL COMPANIES

OpenAIRE

Flavian Clipa; Raluca Irina Clipa

2009-01-01

When the multinational firms employ human resources from different countries they have to submit to the restrictions concerning cultural differences. The paper is an attempt to show how the human resource management administrates these cultural differences.

Multinational banks and credit growth in transition economics

NARCIS (Netherlands)

Haas, Ralph Theodoor Anna de

2006-01-01

This thesis examines the impact of multinational banks (MNBs) on the financial development of European transition countries. On the basis of our results, we conclude that the gradual deepening of the banking systems in Central and Eastern Europe and the Baltic countries (CEB) has enabled firms to

Thin Capitalization Rules and Multinational Firm Capital Structure

NARCIS (Netherlands)

Blouin, J.; Huizinga, H.P.; Laeven, L.; Nicodeme, G.

2014-01-01

Abstract: This paper examines the impact of thin capitalization rules that limit the tax deductibility of interest on the capital structure of the foreign affiliates of US multinationals. We construct a new data set on thin capitalization rules in 54 countries for the period 1982-2004. Using

Multinational corporations and skills development in Nigeria: the ...

African Journals Online (AJOL)

The quest for skills development perhaps accounts for why developing countries like Nigeria attract multinational corporations (MNCs) to their territories to invest in their economies. MNCs are the custodians of skills vital for social and economic transformation of any nation. However, despite their skills advantage, Nigeria ...

Multinational repositories: Ethical, legal and political/public aspects

International Nuclear Information System (INIS)

Boutellier, C.; McCombie, C.; Mele, I.

2006-01-01

Concepts for shared multinational repositories face a great challenge in achieving acceptance, despite the fact that they promise advantages in safety, security, environmental protection and costs. When considering advantages of shared multinational repositories, it is instructive to examine which are the ethical, legal and political issues that mostly affect the feasibility of implementing such facilities. This paper addresses the key questions from two opposite sides. The early part takes a 'top-down' view, looking at the international debate on ethical issues, summarising a wide range of national political attitudes and identifying relevant international legislation and treaties. The latter looks 'bottom-up' at the problem, by discussing the situation of a small country, Slovenia. Slovenia has limited financial resources for implementing disposal - but it has a firm commitment to fulfilling its responsibilities for safely managing all Radioactive Wastes (RAW) arising in the country. Strategies considered to do so are laid out in this paper. (author)

Multinational design evaluation programme. Annual Report April 2016-April 2017

International Nuclear Information System (INIS)

2017-08-01

The Multinational Design Evaluation Program (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities that are currently, or will shortly be, undertaking the review of new reactor power plant designs. MDEP was launched in 2006. In the past ten years, MDEP's reputation as an effective organisation for leveraging the resources and experiences of multiple nations in the regulatory review of new reactors has grown significantly. As a result, the portfolio of new reactor designs that are being addressed have increased from two in 2006 to five in 2017, with a possibility of adding more new reactor designs in the coming years. MDEP's membership has grown from the original 10 national regulators to 15. Over the past year, MDEP design specific working groups have all completed their common positions to address the impact of the Fukushima Daiichi nuclear power plant accident on new reactor designs. New reactor commissioning activities are a major part of all design specific working groups. The EPR and AP1000 Working Groups are particularly active in this area, as together they are overseeing 12 new reactor constructions worldwide. The design specific working groups have finalised a common position to provide high-level guidance to applicants and licensees that wish to take credit for a first plant only test (FPOT). This common position was first implemented in March 2017 at the Taishan 1 plant in China, where regulators and licensees from the United Kingdom, France and Finland witnessed reactor pressure vessel internals vibration tests. The FPOT marked a significant milestone for MDEP since it provided a unique opportunity for regulators involved to demonstrate the efficiency of using common positions to effectively collaborate and share information on test results. This model should be followed as much as possible in other MDEP co-operation areas. Another significant step in multinational regulatory co

Monitoring Costs and Multinational-Bank Lending

OpenAIRE

Ralph de Haas

2006-01-01

We use a two-country model to examine how endogenous changes in monitoring intensity and exogenous changes in monitoring efficiency affect multinational-bank lending. First, an endogenous decline in monitoring intensity limits the amount of deposits that banks can attract. This lowers bank lending. Shocks that reduce bank capital relative to firm capital therefore have a stronger negative effect on bank lending compared to a model with exogenous monitoring intensity. Second, international dif...

Intra-industry trade with multinational firms

OpenAIRE

Egger, H; Egger, P; Greenaway, D

2007-01-01

Recent developments, including the analysis of firm-level adjustment to falling trade costs, have contributed to a revival of interest in intra-industry trade (IIT). Most empirical work still relies on the standard Grubel–Lloyd measure. This however refers only to international trade, disregarding income flows stimulated by repatriated profits of multinational firms. Given the overwhelming importance of the latter, this is a major shortcoming. This paper provides a guide to measurement and es...

Econometric Study of the Relationship between Dimensions of Corporate Responsibility in the Multinational Companies

OpenAIRE

Grosu Maria

2012-01-01

Corporate Responsibility, seen as a fundamental principle of corporate governance, aims contribution must have companies in the development of the modern society. Although it is widely discussed in the literature, the association of corporate responsibility - multinationals assumes, that the globalization of business, multinational companies are ones that have to initiate socially responsible actions, in order to meet changing requirements interest of more sophisticated. Most studies focused ...

Social Networking as a Facilitator for Lifelong Learning in Multinational Employee’s Career

OpenAIRE

Andreea Nicoleta VISAN; Florentina Marinela OLTEANU

2017-01-01

This paper discusses how multinational employees who are leaving in Bucharest, Romania use social networks as a tool for their everyday tasks and work, and how they want to satisfy their personal development needs by having access to information from these digital platforms. The case study described was conducted in Bucharest in 2017 and followed a results analysis with structured tables and graphs. In the study took part 24 participants who were selected among multinational IT employees in B...

Value-Chain Networks and Entrepreneurial Output in Multinational Subsidiaries

DEFF Research Database (Denmark)

Dimitratos, Pavlos; Andersson, Ulf; Liouka, Ioanna

2011-01-01

on their entrepreneurial output. Entrepreneurial output can generate superior performance and positive externalities to the subsidiary. Based on a large-scale study of 268 multinational subsidiaries in the UK, we find that value-chain networks have a higher positive impact than multinational corporation (MNC) networks...... and non value-chain networks; because they may provide the subsidiary knowledge with market opportunities that it lacks and that the other types of networks cannot effectively provide. However, value-chain networks have a negative effect on entrepreneurial output of a subsidiary operating...... in an environment of high uncertainty; because they can constrain the exploration and creation of new knowledge that cannot be provided by any of the networks. Contrary to our expectations, the combined effect of value-chain and non-value chain networks has a negative influence on entrepreneurial output; and...

Evaluating the Investment Benefit of Multinational Enterprises' International Projects Based on Risk Adjustment: Evidence from China

Science.gov (United States)

Chen, Chong

2016-01-01

This study examines the international risks faced by multinational enterprises to understand their impact on the evaluation of investment projects. Moreover, it establishes a 'three-dimensional' theoretical framework of risk identification to analyse the composition of international risk indicators of multinational enterprises based on the theory…

Multinational subsidiary knowledge protection - Do mandates and clusters matter?

NARCIS (Netherlands)

Sofka, Wolfgang; Shehu, Edlira; de Faria, Pedro

2014-01-01

International knowledge spillovers, especially through multinational companies (MNCs), have recently been a major topic of academic and management debate. However, most studies treat MNC subsidiaries as relatively passive actors. We challenge this assumption by investigating the drivers of knowledge

Multinationals, CSR and Partnerships in Central African Conflict Countries

NARCIS (Netherlands)

A. Kolk (Ans); F. Lenfant (François)

2011-01-01

textabstractAttention has increased for the potential role of Multinational Enterprises (MNEs) in helping address conflict issues and/or furthering peace and reconciliation as part of their corporate social responsibility policies. However, while existing literature emphasises the importance for

CULTURAL DIVERSITY AND HUMAN RESOURCE MANAGEMENT IN MULTINATIONAL COMPANIES

Directory of Open Access Journals (Sweden)

Flavian Clipa

2009-09-01

Full Text Available When the multinational firms employ human resources from different countries they have to submit to the restrictions concerning cultural differences. The paper is an attempt to show how the human resource management administrates these cultural differences.

The Cultural Challenges of Managing Global Project Teams: A Study of Brazilian Multinationals

Directory of Open Access Journals (Sweden)

Ivete Rodrigues

2013-04-01

Full Text Available The internationalization of Brazilian companies brings a new reality: the need for implementation of global projects that bring, in turn, the challenge of managing multicultural teams. Since this is a recent phenomenon with little theoretical development, this study sought to understand the relationships between cultural characteristics and management teams of global projects in Brazilian multinationals. To carry this discussion forward, we studied six cases of Brazilian multinational companies, with the aim of deepening the understanding of the management of global teams, involving the planning, deployment, development and management of human resources. Among the projects studied, it was found that there is very little concern with the specific issue of multiculturalism and little inter-cultural incentive to the development of team members, which ends up hindering the construction of a global mindset, important for the Brazilian multinational companies to perform successfully abroad. Faced with this situation, each of the managerial processes mentioned were presented with a number of actions to be undertaken by the project manager in three different dimensions: the project itself, the organization and the global environment. The work contributes, thus, to enable Brazilian multinational companies to manage their global teams in order to maximize the advantages of global teams, such as increased creativity and innovative capacity, but avoid the problems that multiculturalism can bring, ranging from conflicts between people to project failure.

Multinationals, CSR and partnerships in Central African conflict countries

NARCIS (Netherlands)

Kolk, A.; Lenfant, F.

2013-01-01

Attention has increased for the potential role of multinational enterprises (MNEs) in helping address conflict issues and/or furthering peace and reconciliation as part of their corporate social responsibility (CSR) policies. However, while existing literature emphasises the importance for MNEs to

Corporate governance and international location decisions of multinational enterprises

NARCIS (Netherlands)

Dam, L.; Scholtens, B.; Sterken, E.

2007-01-01

This paper analyses international location decisions of corporations based on corporate governance considerations. Using firm level data on 540 Multinational Enterprises (MNEs) with 44,149 subsidiaries in 188 countries, we test whether firms with relatively good governance standards are more often

Taxes and Decision Rights in Multinationals

DEFF Research Database (Denmark)

Nielsen, Søren Bo; Raimondos-Møller, Pascalis; Schjelderup, Guttorm

2006-01-01

We examine how a multinational's choice to centralize or de-centralize itsdecision structure is affected by country tax differentials. Within a simple model that emphasizes the multiple conflicting roles of transfer prices in MNEs — here, as a strategic pre-commitment device and a tax manipulation...... commitment and non-commitment to transfer prices, and for alternative modes of competition.Keywords: Centralized vs. de-centralized decisions, taxes, transfer prices, MNEs.JEL-Classification: H25, F23, L23....

The budgeting and reporting process of a multinational organisation across regions and trade centres

OpenAIRE

Robusti, Fiorenza

2012-01-01

In the contemporary international business environment, a multinational organisation faces great challenges when it comes to budgeting and reporting. The complexity of budgeting and reporting is even greater when it implies the coordination of budgets and reports of trade centres located in other countries than the country of origin. A multinational organisation often adopts the participative budgeting method. The purpose of participative budgeting is to involve managers at lower manage...

Multinational Design Evaluation Programme. Annual Report - April 2014-April 2015

International Nuclear Information System (INIS)

2015-06-01

The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities who are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral co-operation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of MDEP. This report provides a status of the programme after its seventh year of implementation. Content: Executive summary; 1. Introduction; 2. Programme goals and outcomes; 3. Programme implementation (Membership, Organisational structure, MDEP Library, Common positions); 4. Interactions with other organisations; 5. Current activities (EPR Working Group (EPRWG), AP1000 Working Group (AP1000WG), APR1400 Working Group (APR1400WG), VVER Working Group (VVERWG), AVBWR Working Group (ABWRWG), Vendor Inspection Co-operation Working Group (VICWG), Codes and Standards Working Group (CSWG), Digital Instrumentation and Controls Working Group (DICWG)); 6. Interim results; 7. Next steps - Future of the programme; Appendix 1 - List of abbreviations and acronyms; Appendix 2 - Revised documents and publications; Appendix 3 - Photographs of reactors considered within MDEP

Japanese Intercultural Communiccative Strategies in Multinational Companies

OpenAIRE

大山, 中勝

1998-01-01

The purpose of this study is to describe, from a sociolinguistic perspective, major language functions during which Japanese-American communication occurs in multinational companies in the United States. Comparing communication problems across major language functions and research memos, five major themes emerged: (1)foramlity; (2)social hierarchical distinctons; (3)ambiguous communication strategies; (4)consensus making; and (5)language attitudes. This paper also aims to identify the intercu...

Japanese Intercultural Communication Strategies in Multinational Companies

OpenAIRE

大山, 中勝

1997-01-01

The purpose of this study is to describe, from a sociolinguistic perspective, major language functions during which Japanese-American communication occurs in multinational companies in the United States. Comparing communication problems across major language functions and research memos, five major themes emerged: (1)foramlity; (2)social hierarchical distinctons; (3)ambiguous communication strategies; (4)consensus making; and (5)language attitudes. This paper also aims to identify the intercu...

Ownership Concentration and CSR Policy of European Multinational Enterprises

NARCIS (Netherlands)

Dam, Lammertjan; Scholtens, Bert

2013-01-01

This study investigates how ownership concentration in European multinational firms is associated with these firms' corporate social responsibility (CSR). We employ factor analysis on responsibility data from EIRiS and use a regression analysis. Using firm-level data for almost 700 European firms,

Leadership and diversity effectiveness in a large multinational organisation

NARCIS (Netherlands)

Brassey-Schouten, J.

2011-01-01

Effectiviteit van leiderschap en diversiteit krijgen veel aandacht binnen de multinationals van vandaag. De belangrijkste reden is een groeiend geloof en vertrouwen dat leiders en diversiteit een verschil kunnen maken voor de prestatie van een organisatie. In dit onderzoek zijn deze onderwerpen

Gateways to clinical trials.

Science.gov (United States)

Bayés, M; Rabasseda, X; Prous, J R

2007-12-01

Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Trials Knowledge Area of Prous Science Intergrity, the drug discovery and development portal, http://integrity.prous.com. This issue focuses on the following selection of drugs: 249553, 2-Methoxyestradiol; Abatacept, Adalimumab, Adefovir dipivoxil, Agalsidase beta, Albinterferon alfa-2b, Aliskiren fumarate, Alovudine, Amdoxovir, Amlodipine besylate/atorvastatin calcium, Amrubicin hydrochloride, Anakinra, AQ-13, Aripiprazole, AS-1404, Asoprisnil, Atacicept, Atrasentan; Belimumab, Bevacizumab, Bortezomib, Bosentan, Botulinum toxin type B, Brivaracetam; Catumaxomab, Cediranib, Cetuximab, cG250, Ciclesonide, Cinacalcet hydrochloride, Curcumin, Cypher; Darbepoetin alfa, Denosumab, Dihydrexidine; Eicosapentaenoic acid/docosahexaenoic acid, Entecavir, Erlotinib hydrochloride, Escitalopram oxalate, Etoricoxib, Everolimus, Ezetimibe; Febuxostat, Fenspiride hydrochloride, Fondaparinux sodium; Gefitinib, Ghrelin (human), GSK-1562902A; HSV-tk/GCV; Iclaprim, Imatinib mesylate, Imexon, Indacaterol, Insulinotropin, ISIS-112989; L-Alanosine, Lapatinib ditosylate, Laropiprant; Methoxy polyethylene glycol-epoetin-beta, Mipomersen sodium, Motexafin gadolinium; Natalizumab, Nimotuzumab; OSC, Ozarelix; PACAP-38, Paclitaxel nanoparticles, Parathyroid Hormone-Related Protein-(1-36), Pasireotide, Pegfilgrastim, Peginterferon alfa-2a, Peginterferon alfa-2b, Pemetrexed disodium, Pertuzumab, Picoplatin, Pimecrolimus, Pitavastatin calcium, Plitidepsin; Ranelic acid distrontium salt, Ranolazine, Recombinant human relaxin H2, Regadenoson, RFB4(dsFv)-PE38, RO-3300074, Rosuvastatin calcium; SIR-Spheres, Solifenacin succinate, Sorafenib, Sunitinib malate; Tadalafil, Talabostat, Taribavirin hydrochloride, Taxus, Temsirolimus, Teriparatide, Tiotropium bromide, Tipifarnib, Tirapazamine, Tocilizumab; UCN-01, Ularitide

The Dual Role of Multinational Corporations in Cluster Evolution

DEFF Research Database (Denmark)

Østergaard, Christian Richter; Reinau, Kristian Hegner; Park, Eun Kyung

2017-01-01

This chapter shows that multinational corporations play a dual role in cluster evolution through the case of the wireless communications cluster in Northern Denmark. On the one hand, they bring in resources to the cluster, such as financial resources, technology, knowledge, innovation networks, a...

Current Status of Diversity Initiatives in Selected Multinational Corporations.

Science.gov (United States)

Wentling, Rose Mary; Palma-Rivas, Nilda

2000-01-01

Interviews with eight diversity managers in multinational corporations revealed a variety of domestic and international diversity initiatives, especially in leadership and management. Formal and informal methods were used to plan them. Business unit managers were responsible for implementation. Evaluation was difficult and time consuming. (SK)

Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings

Science.gov (United States)

Campbell, Thomas B.; Smeaton, Laura M.; Kumarasamy, N.; Flanigan, Timothy; Klingman, Karin L.; Firnhaber, Cynthia; Grinsztejn, Beatriz; Hosseinipour, Mina C.; Kumwenda, Johnstone; Lalloo, Umesh; Riviere, Cynthia; Sanchez, Jorge; Melo, Marineide; Supparatpinyo, Khuanchai; Tripathy, Srikanth; Martinez, Ana I.; Nair, Apsara; Walawander, Ann; Moran, Laura; Chen, Yun; Snowden, Wendy; Rooney, James F.; Uy, Jonathan; Schooley, Robert T.; De Gruttola, Victor; Hakim, James Gita; Swann, Edith; Barnett, Ronald L.; Brizz, Barbara; Delph, Yvette; Gettinger, Nikki; Mitsuyasu, Ronald T.; Eshleman, Susan; Safren, Steven; Fiscus, Susan A.; Andrade, Adriana; Haas, David W.; Amod, Farida; Berthaud, Vladimir; Bollinger, Robert C.; Bryson, Yvonne; Celentano, David; Chilongozi, David; Cohen, Myron; Collier, Ann C.; Currier, Judith Silverstein; Cu-Uvin, Susan; Eron, Joseph; Flexner, Charles; Gallant, Joel E.; Gulick, Roy M.; Hammer, Scott M.; Hoffman, Irving; Kazembe, Peter; Kumwenda, Newton; Lama, Javier R.; Lawrence, Jody; Maponga, Chiedza; Martinson, Francis; Mayer, Kenneth; Nielsen, Karin; Pendame, Richard B.; Ramratnam, Bharat; Sanne, Ian; Severe, Patrice; Sirisanthana, Thira; Solomon, Suniti; Tabet, Steve; Taha, Taha; van der Horst, Charles; Wanke, Christine; Gormley, Joan; Marcus, Cheryl J.; Putnam, Beverly; Loeliger, Edde; Pappa, Keith A.; Webb, Nancy; Shugarts, David L.; Winters, Mark A.; Descallar, Renard S.; Steele, Joseph; Wulfsohn, Michael; Said, Farideh; Chen, Yue; Martin, John C; Bischofberger, Norbert; Cheng, Andrew; Jaffe, Howard; Sharma, Jabin; Poongulali, S.; Cardoso, Sandra Wagner; Faria, Deise Lucia; Berendes, Sima; Burke, Kelly; Mngqibisa, Rosie; Kanyama, Cecelia; Kayoyo, Virginia; Samaneka, Wadzanai P.; Chisada, Anthony; Faesen, Sharla; Chariyalertsak, Suwat; Santos, Breno; Lira, Rita Alves; Joglekar, Anjali A.; Rosa, Alberto La; Infante, Rosa; Jain, Mamta; Petersen, Tianna; Godbole, Sheela; Dhayarkar, Sampada; Feinberg, Judith; Baer, Jenifer; Pollard, Richard B.; Asmuth, David; Gangakhedkar, Raman R; Gaikwad, Asmita; Ray, M. Graham; Basler, Cathi; Para, Michael F.; Watson, Kathy J.; Taiwo, Babafemi; McGregor, Donna; Balfour, Henry H.; Mullan, Beth; Kim, Ge-Youl; Klebert, Michael K.; Cox, Gary Matthew; Silberman, Martha; Mildvan, Donna; Revuelta, Manuel; Tashima, Karen T.; Patterson, Helen; Geiseler, P. Jan; Santos, Bartolo; Daar, Eric S; Lopez, Ruben; Frarey, Laurie; Currin, David; Haas, David H.; Bailey, Vicki L.; Tebas, Pablo; Zifchak, Larisa; Noel-Connor, Jolene; Torres, Madeline; Sha, Beverly E.; Fritsche, Janice M.; Cespedes, Michelle; Forcht, Janet; O'Brien, William A.; Mogridge, Cheryl; Hurley, Christine; Corales, Roberto; Palmer, Maria; Adams, Mary; Luque, Amneris; Lopez-Detres, Luis; Stroberg, Todd

2012-01-01

Background Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world. Methods and Findings 1,571 HIV-1-infected persons (47% women) from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV), atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC), or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF) (EFV+FTC-TDF). ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR) was ≤1.35 when 30% of participants had treatment failure. An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18%) among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72–1.27; p = 0.74). Safety endpoints occurred in 243 (46%) participants assigned to EFV+FTC-TDF versus 313 (60%) assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54–0.76; p<0.001) and there was a significant interaction between sex and regimen safety (HR 0.50, CI 0.39–0.64 for women; HR 0.79, CI 0.62–1.00 for men; p = 0.01). Comparing ATV+DDI+FTC to EFV+3TC-ZDV, during a median follow-up of 81 wk there were 108 failures (21%) among 526 participants assigned to ATV+DDI+FTC and 76 (15%) among 519 participants assigned to EFV+3TC-ZDV (HR 1.51, CI 1.12–2.04; p = 0.007). Conclusion EFV+FTC-TDF had similar high efficacy compared to EFV+3TC-ZDV in this trial population, recruited in diverse multinational settings. Superior safety, especially in HIV-1-infected

Local Nordic tobacco interests collaborated with multinational companies to maintain a united front and undermine tobacco control policies.

Science.gov (United States)

Hiilamo, Heikki; Glantz, Stanton A

2013-03-01

To analyse how local tobacco companies in the Nordic countries, individually and through National Manufacturers' Associations, cooperated with British American Tobacco and Philip Morris in denying the health hazards of smoking and undermining tobacco control. Analysis of tobacco control policies in the Nordic countries and tobacco industry documents. Nordic countries were early adopters of tobacco control policies. The multinational tobacco companies recognised this fact and mobilised to oppose these policies, in part because of fear that they would set unfavourable precedents. Since at least 1972, the Nordic tobacco companies were well informed about and willing to participate in the multinational companies activities to obscure the health dangers of smoking and secondhand smoke and to oppose tobacco control policies. Cooperation between multinational companies, Nordic national manufacturer associations and local companies ensured a united front on smoking and health issues in the Nordic area that was consistent with the positions that the multinational companies were taking. This cooperation delayed smoke-free laws and undermined other tobacco control measures. Local tobacco companies worked with multinational companies to undermine tobacco control in distant and small Nordic markets because of concern that pioneering policies initiated in Nordic countries would spread to bigger market areas. Claims by the local Nordic companies that they were not actively involved with the multinationals are not supported by the facts. These results also demonstrate that the industry appreciates the global importance of both positive and negative public health precedents in tobacco control.

Multinational teams in European and American companies

OpenAIRE

Numic, Aida

2007-01-01

Incorporating team context into research and practice concerning team effectiveness in multinational organizations still remains an ongoing challenge. The purpose of this dissertation was to explore the influence of industry, corporate culture, structure, strategy and task characteristics on MNTs in business organizations and to develop a more comprehensive framework connecting the internal dynamics with contextual aspects of MNTs functioning in companies in Europe and the USA. The study was ...

Increasing Absorptive Capacity to Improve Internal and External Knowledge Transfer in Multinational Companies: A Multiple Case Study Approach

Directory of Open Access Journals (Sweden)

Béla-Gergely RÁCZ

2016-12-01

Full Text Available This study investigates how the absorptive capacity could be increased to improve internal and external knowledge transfer in subsidiaries of multinational companies. We look at the way in which the literature on absorptive capacity has evolved, and how it links the internal and external knowledge transfer. Based on 3 case studies conducted at Romanian subsidiaries of multinational companies, we find some patterns, which could explain how the successful knowledge flows should be managed within the multinational company and outside of it, in the supply chain network.

The Transmission of Real Estate Shocks Through Multinational Banks

NARCIS (Netherlands)

Bertay, A.C.

2014-01-01

Abstract: This paper investigates the credit supply of banks in response to domestic and foreign real estate price changes. Using a large international dataset of multinational banks, we find evidence of a significant transmission of domestic real estate shocks into lending abroad. A 1% decrease in

Competitive Advantage and the Existence of the Multinational Corporation

DEFF Research Database (Denmark)

Geisler Asmussen, Christian; Foss, Nicolai Juul

2014-01-01

This article provides a counterpoint to Hashai and Buckley's article ‘Is competitive advantage a necessary condition for the emergence of the multinational enterprise?’ We agree with their conclusion that it is, in fact, not a necessary condition, but argue that the theoretical reasons behind thi...

Komi oil spill - An assessment by a multinational team

Energy Technology Data Exchange (ETDEWEB)

Devenis, P.

1995-12-31

The mission objectives, findings of an on-site visit, and recommendations of a multinational United Nations team who assessed the Komi oil spill in Russia were discussed, combined with a discussion of the findings and field work of Russian investigators, whose work preceded that of the UN team. Concern was expressed over spring flooding as a unique problem that might well complicate the cleanup. Areas of serious concern were identified by the group and recommendations for remediation were made, and described in detail. It was found that the multinational team approach was a successful answer in this particular situation in that the diverse backgrounds and experiences of the team members resulted in better solutions and recommendations for remediation than would have been possible otherwise. Access to information provided by EMERCOM (the Russian Ministry for Emergency Response to Natural Disasters) and the Russian consulting firm, helped the UN team in overcoming time constraints and other obstructions affecting their work. 5 refs., 2 figs.

CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues

Directory of Open Access Journals (Sweden)

Sarah A. Abd El-Aal

2017-10-01

Full Text Available Statins were reported to lower the Coenzyme Q10 (CoQ10 content upon their inhibition of HMG-CoA reductase enzyme and both are known to possess neuroprotective potentials; therefore, the aim is to assess the possible use of CoQ10 as an adds-on therapy to rosuvastatin to improve its effect using global I/R model. Rats were allocated into sham, I/R, rosuvastatin (10 mg/kg, CoQ10 (10 mg/kg and their combination. Drugs were administered orally for 7 days before I/R. Pretreatment with rosuvastatin and/or CoQ10 inhibited the hippocampal content of malondialdehyde, nitric oxide, and boosted glutathione and superoxide dismutase. They also opposed the upregulation of gp91phox, and p47phox subunits of NADPH oxidase. Meanwhile, both agents reduced content/expression of TNF-α, iNOS, NF-κBp65, ICAM-1, and MPO. Besides, all regimens abated cytochrome c, caspase-3 and Bax, but increased Bcl-2 in favor of cell survival. On the molecular level, they increased p-Akt and its downstream target p-FOXO3A, with the inhibition of the nuclear content of FOXO3A to downregulate the expression of Bim, a pro-apoptotic gene. Additionally, both treatments downregulate the JNK3/c-Jun signaling pathway. The effect of the combination regimen overrides that of either treatment alone. These effects were reflected on the alleviation of the hippocampal damage in CA1 region inflicted by I/R. Together, these findings accentuate the neuroprotective potentials of both treatments against global I/R by virtue of their rigorous multi-pronged actions, including suppression of hippocampal oxidative stress, inflammation, and apoptosis with the involvement of the Akt/FOXO3A/Bim and JNK3/c-Jun/Bax signaling pathways. The study also nominates CoQ10 as an adds-on therapy with statins.

Multinational design evaluation programme. Annual Report April 2015-April 2016

International Nuclear Information System (INIS)

2016-05-01

The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities that are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral co-operation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides, and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of MDEP. This report provides a status of the programme after its eighth year of implementation. Content: Executive Summary; 1 - Introduction; 2 - Programme goals and outcomes; 3 - Programme implementation (Membership, Organizational structure, MDEP Library, Common positions); 4 - Interactions with other organizations; 5 - Current activities (EPR Working Group (EPRWG), AP1000 Working Group (AP1000WG), APR1400 Design-specific Working Group (APR1400WG), VVER Working Group (VVERWG), ABWR Working Group (ABWRWG), Vendor Inspection Co-operation Working Group (VICWG), Codes and Standards Working Group (CSWG), Digital Instrumentation and Controls Working Group (DICWG); 6 - Interim results; 7 - Next steps - future of the programme; appendix 1: List of abbreviations and acronyms; Appendix 2: Revised documents and publications; Appendix 3: Photographs of reactors considered within MDEP

Bayer HealthCare Delivers a Dose of Reality for Cloud Payoff Mantras in Multinationals

DEFF Research Database (Denmark)

Winkler, Till J.; Benlian, Alexander; Piper, Marc

2014-01-01

Cloud services provide high cost advantages” is one of several often-quoted assertions (called mantras in this article) about payoffs from cloud computing. These mantras, however, have their origins in the experiences of small and mid-size companies, but, as the case of Bayer HealthCare’s cloud-b......-based CRM rollout program shows, may not always be true for large multinational companies. To ensure payoffs from the cloud, multinationals must adopt strategies for coping with the inhibitors identified in this article....

Knowledge protection strategies of multinational firms-A cross-country comparison

NARCIS (Netherlands)

de Faria, Pedro; Sofka, Wolfgang

International knowledge spillovers, especially through multinational companies (MNCs), have recently been a major topic of discussion among academics and practitioners. Most research in this field focuses on knowledge sharing activities of MNC subsidiaries. Relatively little is known about their

A non-traditional multinational approach to construction inspection program

International Nuclear Information System (INIS)

Ram, Srinivasan; Smith, M.E.; Walker, T.F.

2007-01-01

The next generation of nuclear plants would be fabricated, constructed and licensed in markedly different ways than the present light water reactors. Non-traditional commercial nuclear industry suppliers, shipyards in Usa and international fabricators, would be a source to supply major components and subsystems. The codes of construction may vary depending upon the prevailing codes and standards used by the respective supplier. Such codes and standards need to be reconciled with the applicable regulations (e.g., 10 CFR 52). A Construction Inspection Program is an integral part of the Quality Assurance Measures required during the Construction Phase of the power plant. In order to achieve the stated cost and schedule goals of the new build plants, a nontraditional multi-national approach would be required. In lieu of the traditional approach of individual utility inspecting the quality of fabrication and construction, a multi-utility team approach is a method that will be discussed. Likewise, a multinational cooperative licensing approach is suggested taking advantage of inspectors of the regulatory authority where the component would be built. The multi-national approach proposed here is based on the principle of forming teaming agreements between the utilities, vendors and the regulators. For instance, rather than sending Country A's inspectors all over the world, inspectors of the regulator in Country B where a particular component is being fabricated would in fact be performing the required inspections for Country A's regulator. Similarly teaming arrangements could be set up between utilities and vendors in different countries. The required oversight for the utility or the vendor could be performed by their counterparts in the country where a particular item is being fabricated

Centralized vs. de-centralized multinationals and taxes

OpenAIRE

Nielsen, Søren Bo; Raimondos-Møller, Pascalis; Schjelderup, Guttorm

2005-01-01

The paper examines how country tax differences affect a multinational enterprise's choice to centralize or de-centralize its decision structure. Within a simple model that emphasizes the multiple conflicting roles of transfer prices in MNEs – here, as a strategic pre-commitment device and a tax manipulation instrument –, we show that (de-)centralized decisions are more profitable when tax differentials are (small) large. Keywords: Centralized vs. de-centralized decisions, taxes, MNEs. ...

Local Nordic tobacco interests collaborated with multinational companies to maintain a united front and undermine tobacco control policies

Science.gov (United States)

Hiilamo, Heikki; Glantz, Stanton A

2012-01-01

Objective To analyse how local tobacco companies in the Nordic countries, individually and through National Manufacturers’ Associations, cooperated with British American Tobacco and Philip Morris in denying the health hazards of smoking and undermining tobacco control. Methods Analysis of tobacco control policies in the Nordic countries and tobacco industry documents. Results Nordic countries were early adopters of tobacco control policies. The multinational tobacco companies recognised this fact and mobilised to oppose these policies, in part because of fear that they would set unfavourable precedents. Since at least 1972, the Nordic tobacco companies were well informed about and willing to participate in the multinational companies activities to obscure the health dangers of smoking and secondhand smoke and to oppose tobacco control policies. Cooperation between multinational companies, Nordic national manufacturer associations and local companies ensured a united front on smoking and health issues in the Nordic area that was consistent with the positions that the multinational companies were taking. This cooperation delayed smoke-free laws and undermined other tobacco control measures. Conclusions Local tobacco companies worked with multinational companies to undermine tobacco control in distant and small Nordic markets because of concern that pioneering policies initiated in Nordic countries would spread to bigger market areas. Claims by the local Nordic companies that they were not actively involved with the multinationals are not supported by the facts. These results also demonstrate that the industry appreciates the global importance of both positive and negative public health precedents in tobacco control. PMID:22199013

Multinational Firms and Business Cycle Transmission

DEFF Research Database (Denmark)

Menno, Dominik Francesco

This paper studies the effect of foreign direct investment (FDI) on the transmission of international business cycles. I document for the G7 countries between 1991 and 2006 that increases in bilateral FDI linkages are associated with more synchronized investment cycles. I also find...... that the relation between FDI integration and synchronization of gross domestic product (GDP) is - yet positive - statistically insignificant after controlling for time fixed effects. I then study a model of international business cycles with an essential role for FDI and shocks to multinational activity...

Investigating the Process of Valuing Investments in Intangibles: A Case Study in Safety and Security in the Multinational Hotel Industry

OpenAIRE

Punpugdee, Nuttapon

2005-01-01

Safety and security have emerged as a major force driving change in the multinational hotel industry. As a problem area not well-developed in the literature but considered a crucial force influencing hotel firms' value by the multinational hotel community, safety and security provide an excellent opportunity for industry professionals and academic researchers to improve the value creation of multinational hotel firms. A research need is more urgent in the upscale sector of the industry, and t...

A Cost-based Explanation of Gradual, Regional Internationalization of Multinationals on Social Networking Sites

DEFF Research Database (Denmark)

Pogrebnyakov, Nicolai

2017-01-01

This paper examines firm internationalization on social networking sites (SNS). It systematically examines costs faced by an internationalizing firm and how firms react to these costs according to “distance-dependent” (gradual and regional) and “distance-invariant” (born-global) explanations...... of internationalization. Data on 5827 country pages of 240 multinational firms on Facebook, the most popular SNS today, is used. Creating a foreign country-specific Facebook page is considered the SNS equivalent of opening a physical subsidiary in that country. The data show that multinationals exhibit...

Winds of change: corporate strategy, climate change and oil multinationals

NARCIS (Netherlands)

Kolk, A.; Levy, D.L.

2001-01-01

Behind pessimistic expectations regarding the future of an international climate treaty, substantial changes can be observed in company positions. Multinationals in the oil and car industries are increasingly moving toward support for the Kyoto Protocol, and take measures to address climate change.

HRM implementation in multinational companies : the dynamics of multifaceted scenarios

NARCIS (Netherlands)

Bos-Nehles, Anna; Bondarouk, Tanya; Labrenz, Soren

2017-01-01

This study explores why the subsidiary line managers of multinational companies (MNCs) implement HRM practices differently than intended by headquarters. HRM implementation is understood as a process in which one has to differentiate between a range of multifaceted HRM implementation scenarios. We

LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases--a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial

Directory of Open Access Journals (Sweden)

Schimanski Carl

2012-04-01

Full Text Available Abstract Background 15-20% of all patients initially diagnosed with colorectal cancer develop metastatic disease and surgical resection remains the only potentially curative treatment available. Current 5-year survival following R0-resection of liver metastases is 28-39%, but recurrence eventually occurs in up to 70%. To date, adjuvant chemotherapy has not improved clinical outcomes significantly. The primary objective of the ongoing LICC trial (L-BLP25 In Colorectal Cancer is to determine whether L-BLP25, an active cancer immunotherapy, extends recurrence-free survival (RFS time over placebo in colorectal cancer patients following R0/R1 resection of hepatic metastases. L-BLP25 targets MUC1 glycoprotein, which is highly expressed in hepatic metastases from colorectal cancer. In a phase IIB trial, L-BLP25 has shown acceptable tolerability and a trend towards longer survival in patients with stage IIIB locoregional NSCLC. Methods/Design This is a multinational, phase II, multicenter, randomized, double-blind, placebo-controlled trial with a sample size of 159 patients from 20 centers in 3 countries. Patients with stage IV colorectal adenocarcinoma limited to liver metastases are included. Following curative-intent complete resection of the primary tumor and of all synchronous/metachronous metastases, eligible patients are randomized 2:1 to receive either L-BLP25 or placebo. Those allocated to L-BLP25 receive a single dose of 300 mg/m2 cyclophosphamide (CP 3 days before first L-BLP25 dose, then primary treatment with s.c. L-BLP25 930 μg once weekly for 8 weeks, followed by s.c. L-BLP25 930 μg maintenance doses at 6-week (years 1&2 and 12-week (year 3 intervals unless recurrence occurs. In the control arm, CP is replaced by saline solution and L-BLP25 by placebo. Primary endpoint is the comparison of recurrence-free survival (RFS time between groups. Secondary endpoints are overall survival (OS time, safety, tolerability, RFS/OS in MUC-1 positive

Pre-Interaction Management in Multinational Companies in Central Europe

Science.gov (United States)

Nekvapil, Jiri; Sherman, Tamah

2009-01-01

This article is devoted to the linguistic, communicative and sociocultural situation in branches of multinational companies located in the Czech Republic and Hungary. There are typically several languages used in these branches. In addition to the local languages, there are the languages of the parent companies--most commonly English or German,…

A license to mine? : Community organizing against multinational corporations

NARCIS (Netherlands)

R. Krämer (Romy)

2016-01-01

textabstractWhat does it mean when a corporation claims to have a ‘license to operate’ in a local community? How does a member of an indigenous tribe make it to London to protest against a multinational mining company? How do managers perceive and speak about protest against their company and how

Multi-national knowledge strategies, policy and the upgrading process of regions: Revisiting the automotive industry in Ostrava and Shanghai

NARCIS (Netherlands)

Tuijl, E. van; Carvalho, L.; Winden, W. van; Jacobs, W.A.A.

2012-01-01

This paper revisits how and why new multinational knowledge-based strategies and multi-level governmental policies influence the upgrading process of regions in developing economies. Automotive multinationals traditionally exploited local asset conditions, but it is shown that they have also been

Corporate Profit Shifting and the Multinational Enterprise

OpenAIRE

Webber, Stuart

2012-01-01

This dissertation analyzes ways in which Multinational Enterprises (MNEs) shift profits from one country to another to reduce their income tax expense. This is an important topic for a number of reasons. From a country’s perspective, its income tax rates and policies can have a significant impact upon its tax revenue, economic competitiveness, and the vibrancy of its economy. From the MNE’s perspective, income tax rates and policies determine a firm’s tax obligations, and thus ...

Regional Multinationals and the Korean Comestics Industry

OpenAIRE

Chang Hoon Oh; Alan M. Rugman

2007-01-01

This paper analyzes the market penetration and expansion strategy of cosmetics and toiletries multinational enterprises (MNEs) in South Korea from the perspective of regional strategy as developed recently by Rugman. We find that MNEs have different market entry and expansion strategies in the home region and in the foreign region. Home region MNEs (Japanese MNEs in this case), in general, utilize their firm-specific advantages (FSAs) better than foreign region MNEs (European and MNEs from th...

Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review.

Science.gov (United States)

Ângelo, Marilene Lopes; Moreira, Fernanda de Lima; Morais Ruela, André Luís; Santos, Ana Laura Araújo; Salgado, Hérida Regina Nunes; de Araújo, Magali Benjamim

2018-07-04

Rosuvastatin calcium (ROS), ( Figure 1 ) belongs to the "statins" group, which is the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. This drug is indicated for dyslipidemias treatment and can help to decrease the level of "bad cholesterol" and can consequently reduce the development of atherosclerosis and the risk of heart diseases. ROS was developed by Astra-Zeneca and it was approved in 2003 by the FDA in the United States. In 2015, under the trade name Crestor®, it was the fourth largest selling drug in the United States with sales above $5 billion. This study presents a literature review of analytical methods for the quantification of ROS in pharmaceutical preparations and biological fluids. The major analytical methods described in this study for ROS were spectrophotometry, high-performance liquid chromatography (HPLC) coupled to ultraviolet (UV) detection, and tandem mass spectrometry (LC-MS/MS).

Mapping R&D within Multinational Networks: Evidence from the Electronics Industry

Science.gov (United States)

Urze, Paula; Manatos, Maria João

Based on the final results of the R&D.COM - Local R&D COMpetencies within Global Value Chains project, this paper aims at mapping the trajectories of delocalised R&D units within a multinational’s global strategy and designing the knowledge flows within the global value chain. This analysis was performed using typologies proposed in the theoretical framework, which help us to have an overview of the network. The methodology is grounded on one extended case study that involves a local R&D unit (Portugal), a foreign R&D unit (Netherlands) and the headquarters (Norway) - developed on a multinational from the electronics industry. This case is an example of a multinational company where R&D is developed mainly in the headquarters but it is also delocalised to some subsidiaries with a certain level of autonomy.

Multinational cash management and conglomerate discounts in the euro zone

NARCIS (Netherlands)

Eije, Henk von; Westerman, Wim

2001-01-01

We discuss the impact of liberalisation, deregulation and the introduction of a single currency on cash management within multinationals in the euro zone. The developments in the euro zone reduce financial market imperfections in transferring cash and diminish the need for separate local cash

Are less developed countries more exposed to multinational tax avoidance?

DEFF Research Database (Denmark)

Johannesen, Niels; Tørsløv, Thomas Rasmusen; Wier, Ludvig

We use a global dataset with information on 210,000 corporations in 102 countries to investigate whether cross-border profit shifting by multinational firms is more prevalent in less developed countries. We propose a novel technique to study aggressive profit shifting and improve the credibility ...

Socially acceptable enterprising of the Netherlands in China. Investigation of the performance of Dutch multinationals

International Nuclear Information System (INIS)

Bakker, H.G.M.; Koppert, P.

2005-01-01

An effective tool has been developed by means of which companies can investigate their foreign offices or establishments with respect to people (labor conditions), planet (environmental effects), and profit (economic efficiency). In order to test the tool, offices and establishments of multinational enterprises in both the Netherlands and in China were visited. The Dutch offices perform better than the offices in China, although claims of the main office of the multinationals could not be verified on the 'shop-floor' [nl

Redistributive taxation, multinational enterprises, and economic integration

OpenAIRE

Haufler, Andreas; Klemm, Alexander; Schjelderup, Guttorm

2008-01-01

Increased activity of multinational firms exposes national corporate tax bases to cross-country profit shifting, but also leads to rising profitability of the corporate sector. We incorporate these two effects of economic integration into a simple political economy model where the median voter decides on a redistributive income tax rate. In this setting economic integration may raise or lower the equilibrium tax rate, and it is more likely to raise the tax rate of a low-tax country. The impli...

How Subsidiaries Gain Power in Multinational Corporations

DEFF Research Database (Denmark)

Mudambi, Ram; Pedersen, Torben; Andersson, Ulf

2014-01-01

in multinational firms. Data collected from 2107 foreign-owned subsidiaries in seven European countries is used to test the hypotheses. The results indicate that mutual dependence and dependence imbalance provide strong explanations for subsidiary power. Furthermore, subsidiary power over strategic decisions...... in the MNC is gained through functional power, notably the possession of technological, rather than business-related, power or by the possession of both as they reinforce each other in strengthening the subsidiary's strategic power in the MNC network...

Multinationals and plant survival

DEFF Research Database (Denmark)

Bandick, Roger

2010-01-01

The aim of this paper is twofold: first, to investigate how different ownership structures affect plant survival, and second, to analyze how the presence of foreign multinational enterprises (MNEs) affects domestic plants’ survival. Using a unique and detailed data set on the Swedish manufacturing...... sector, I am able to separate plants into those owned by foreign MNEs, domestic MNEs, exporting non-MNEs, and purely domestic firms. In line with previous findings, the result, when conditioned on other factors affecting survival, shows that foreign MNE plants have lower survival rates than non......-MNE plants. However, separating the non-MNEs into exporters and non-exporters, the result shows that foreign MNE plants have higher survival rates than non-exporting non-MNEs, while the survival rates of foreign MNE plants and exporting non-MNE plants do not seem to differ. Moreover, the simple non...

Personnel motivation in multinational companies : standardization and adaptation

OpenAIRE

Stepanyan, Anna

2016-01-01

With the increasing emergence of multinational companies and the increased popularity of these companies, the question of the organization of their activities becomes interesting for the HR community worldwide. These companies are renowned for deliberate management structure of human resources and their effective use. For effective use of employees’ skills and knowledge the company has to constantly motivate them by intrinsic and extrinsic motivational tools. Motivational tools which use a co...

Clinical trials in India.

Science.gov (United States)

Maiti, Rituparna; M, Raghavendra

2007-07-01

The concept of outsourcing for the development and global studies on new drugs has become widely accepted in the pharmaceutical industry due to its cost and uncertainty. India is going to be the most preferred location for contract pharma research and development due to its huge treatment naïve population, human resources, technical skills, adoption/amendment/implementation of rules/laws by regulatory authorities, and changing economic environment. But still 'miles to go' to fulfill the pre-requisites to ensure India's success. In spite of all the pitfalls, the country is ambitious and optimist to attract multinational pharmaceutical companies to conduct their clinical trials in India.

SOCIOLINGUISTIC AND CULTURAL CHARACTERISTICS OF FOREIGN LANGUAGES IN THE MULTINATIONAL STATE

Directory of Open Access Journals (Sweden)

Irina Ivanovna Skachkova

2013-11-01

Full Text Available In the context of globalization and increasing international cooperation in different spheres of life the issue of national security and economic prosperity of nations is becoming increasingly urgent.Purpose: Consideration of sociolinguistic and cultural characteristics of the functioning of foreign languages in a multinational state, the example of the United States.Methodology: We used general scientific methods: analysis and synthesis, comparison, generalization, systematic approach.Results: It is concluded that foreign languages in a multinational state, such as the U.S., are studied through active actions of government, public and educational institutions, and the main purpose of language learning is to maintain national security and economic competitiveness in the international arena.Practical implications: The results of the work may be used both in linguistic theory, and sociolinguistics.DOI: http://dx.doi.org/10.12731/2218-7405-2013-7-51

A Snapshot of the World of Global Multinationals – An Industry Based Analysis of Fortune Global 500 Companies

Directory of Open Access Journals (Sweden)

Ogrean Claudia

2017-08-01

Full Text Available For better or for worse, the “corporations rule the world” assertion is nowadays more actual and accurate than ever before, as multinational companies represent the undisputable engine of the globalization process, and the latter continuously (recreates the background against which global multinationals are flourishing, while reinforcing their “domination”. Since 1995, the Fortune Global 500 ranking (FG 500 annually provides a comprehensive and eloquent image of the world of global multinationals; the merits of the FG 500 ranking go beyond the synchronic approach of the characteristics of global multinationals (in terms of revenues, profits, assets and employees - by sector, industry and country, as it also favors diachronic analysis and comparisons - which are essential for strategists in identifying evolving trends and substantiating corporate strategies able to lead to sustainable competitiveness. The paper aims to determine the contribution of sectors to FG 500 ranking in 2016, on one hand, and to emphasize on some industry-based dynamics in FG 500 - by comparatively analyzing the 2016 and 1996 rankings, on the other hand.

Business & IT Alignment in a Multinational Company; Issues and approaches

NARCIS (Netherlands)

Drs. A.J.G. Silvius

This chapter explores the theory and practice of Business & IT Alignment in multinational companies. In the first part of the chapter an overview of the theory is presented. In this part the familiar frameworks for Business & IT Alignment are put in perspective in an ‘Alignment development model’.

The Management of Training in Multinational Corporations: Comparative Case Studies.

Science.gov (United States)

Noble, Charles

1997-01-01

Case studies of British and Australian multinational corporations in the food and drink industry investigated how training and development are managed. Competency-based education and industry boards are important elements in both countries. Lack of a training culture in the industry and little innovation in training were observed. (SK)

Why and how multinational enterprises can be value-creating organizations

NARCIS (Netherlands)

Hennart, J.M.A.

2015-01-01

Rugman made the valid point that Multinational Enterprises are value-creating organizations but in this piece I question his explanation of why this is the case. I argue that it is not, as Rugman proposed, because MNEs are better at safeguarding their firm-specific advantages (FSAs) but because

Advancing Understanding on Industrial Relations in Multinational Companies: Key Research Challenges and the INTREPID Contribution

DEFF Research Database (Denmark)

Gunnigle, Patrick; Valeria, Pulignano; Edwards, Tony

2015-01-01

companies using INTREPID (Investigation of Transnationals’ Employment Practices: an International Database) data. Finally, the paper identifies some of the main industrial relations issues that remain to be addressed, in effect charting a form of research agenda for future work using the INTREPID data......This paper has three principal aims. It firstly provides some theoretical background on the key current research issues and challenges in regard to industrial relations in multinational companies. It then presents a concise review of scholarship to date on industrial relations in multinational...

THE EXPANSION OF THE TRANSNATIONAL AND MULTINATIONAL CORPORATIONS IN THE GLOBAL ECONOMY

Directory of Open Access Journals (Sweden)

Paul-Bogdan Zamfir

2012-12-01

Full Text Available The phenomenon of transnationalisation and multinationalisation evokes just the differences between the two types of corporations. It can be said that a transnational company is above geographical boundaries, wich from the perspective of revolutionary technological communications and transport have been dimmed, but above the borders represented by language, culture, mentalities and technology. The transnational company operates spot transactions because it is listed on the various first rank Stock Exchanges and the financial, technical, image and brand results recorded by this, are public information that it is measuring the success or unsucces of the transnationalisations phenomenon. By comparison, the multinational company is listed either at stock exchanges of secondary importance, or it is a group or family bussines which has the active abroad. At the same time the multinational corporations effectively produce without to generate significant resources for the development of it's own research activities, so, having failed to impose an uniform structure and culture regardless of the assets location. Another significant difference is at the financing access. The transnational company is standing in attention of the rating firms having a low-risk investment that it allows to access the financing at low cost. In most cases, multinational society has limited financial funding in the country of origin, sometimes exclusive relying on the raised funds of the branches which it controls.

Danish Multinational Corporations in China

DEFF Research Database (Denmark)

Haakonsson, Stine Jessen

2017-01-01

markets, which are significantly different from MNCs' traditional locations. As globalisation progresses, internationalisation increasingly involves exploitation strategies, i.e., offshoring of production; market access; and exploration strategies such as internationalisation of innovation. This article......Multinational corporations (MNCs) strategise in a dynamic multi-polar world consisting of changing environments at home and abroad. They continuously face a new set of push- and pull-factors for internationalising activities. In recent decades, internationalisation has been reaching into emerging...... looks into how Danish MNCs have evolved into the Chinese economy, investigating the trajectories of how and when four Danish MNCs entered the Chinese economy and how the strategy patterns have emerged from cost reduction, to market access, and recently to innovation. Over 30 years, China has developed...

RUSSIAN MULTINATIONALS IN ROMANIA AND THEIR IMPACT UPON THE ROMANIAN ECONOMY

Directory of Open Access Journals (Sweden)

CODRUŢA DURA

2012-01-01

Full Text Available Our paper provides an insight into the universe of Russian multinationals and their influence upon the Romanian economy. Even if statistical data on foreign direct investment stock by country of origin do not prove the existence of Russian capital in Romania, it is a fact that the high values of foreign direct investment stock from the Netherlands, Austria, Germany or Switzerland are largely due to the investment projects undertaken in Romania by Russian multinationals. Despite the lack of relevant statistical data, we can say that the impact of Russian MNC’s on the Romanian economy is huge. Among positive influences we can mention: global employment opportunities for highly qualified workforce in the region; the transfer of advanced technologies to Romanian enterprises and the local markets; the awareness of business partners and public opinion on social responsibility; the insert of higher performance standards, competitiveness and managerial ethics.

Disruptive Innovation by Emerging Multinational Latecomers

DEFF Research Database (Denmark)

Li, Peter Ping

Despite the growing interest in the emerging-economy multinational enterprise (EMNE), there is little knowledge about the underlying mechanism for EMNEs as latecomers to catch up with and even leapfrog the traditional MNEs as early-movers. The cross-fertilization between the research streams...... of latecomer innovation as a special DI by EMNE at BOP to provide insights into the mechanisms underlying the trajectories of catching up and leapfrogging. Built upon latecomer innovation, EMNEs at BOP can emerge as the most disruptive challengers to the MNE incumbents at TOP. The implications of reframed...... constructs, integrative typology, and emerging theory for research and practice are also discussed....

Multinational Exploration of Acquired R&D Activities

DEFF Research Database (Denmark)

Gammelgaard, Jens

2004-01-01

R&D. This paper establishes the connection between amultinational corporation that follows a capability-motivated acquisition strategy and theR&D role new subsidiaries should play in order for the acquired resources to be utilizedcorporation-wide. Statistical findings reveal the need to follow......This paper presents the results of a survey of 54 Danish multinational corporations that haveacquired activities abroad. The role of the acquired R&D units was the focus of the survey,particularly with respect to the schism between basic and applied R&D, and the schismbetween autonomous and network...

Towards strategic CSR in the multinational corporations

DEFF Research Database (Denmark)

Linneberg, Mai Skjøtt; Thorup-Jensen, Line

2014-01-01

CSR is a context-specific phenomenon, which makes working strategically with CSR particularly challenging for multinational corporation as it must allow for the various contexts of operation. Based on the extant literature, this article provides a conceptual presentation of MNC's opportunities...... to work with CSR acknowledging and taking into account the the context embeddedness of CSR. We propose that MNCs consider four decision areas establishwhen developing strategic CSR. Furthermore, we present a framework model for CSR that takes into account the MNC's need to consider both a local...

Essays on Multinational Production and International Trade

DEFF Research Database (Denmark)

Clementi, Federico

This Thesis consists of an introduction followed by three independent chapters. Each chapter is a self-contained paper that can be read independently. They cover different topics of international economics with a specific focus on multinational production and international trade. A common feature...... the intensity of spillovers to local suppliers. Domestic firms benefit only from the activity of foreign clients that are not vertically integrated in their industry. In the last chapter, I use a detailed dataset of international transactions of Danish companies to study the impact of Chinese competition...

Current status and perspective of multinational design evaluation program in Korea

International Nuclear Information System (INIS)

Sung, Key Yong

2008-01-01

The Multinational Design Evaluation Program (MDEP) is a multinational initiative to develop innovative approaches to leverage the resources and knowledge of the national regulatory authorities who will be tasked with the review of new reactor power plant designs. MDEP consisted of three stages: Stage 1 involved multilateral cooperation within existing regulatory frameworks; Stage 2 focused on enhanced multinational cooperation and convergence of codes, standards, and safety goals; and Stage 3 involved implementation of Stage 2 products to facilitate licensing processes for new reactors, including those being developed by the Generation IV International Forum. A year-long pilot project was initiated to assess the feasibility of the Stage 2 goals since October 2006. The main objective of Stage 2, as set in the Terms of Reference (ToR), was to establish reference regulatory practices and regulations to enhance the safety of new nuclear reactor designs. The convergence of regulatory practices and regulations associated with the reactor design reviews should allow for enhanced cooperation among regulators, improving the effectiveness and efficiency of the regulatory design reviews, which are part of each country's licensing process. This is expected to lead to a convergence of codes, standards and safety goals in the participating countries. To this end, a pilot project, consisting of two working groups, was launched. The first working group investigated the licensing basis for new nuclear reactor designs, the scope of design safety reviews and overall safety goals. The second examined regulatory oversight of components manufactured for new nuclear reactors

THE EFFECT OF ISLAMIC WORK ETHICS ON THE PERFORMANCE RESULT OF MUSLIM EMPLOYEES OF MARKETING SECTOR IN THE MULTINATIONAL COMPANIES

Directory of Open Access Journals (Sweden)

Mitra Hadisi

2014-06-01

Full Text Available This study investigates the effect of Islam on efficiency of Muslim employees in multinational companies. The findings of the studies conducted to date examining the potential and actual impact of Islam in multinational setting indicates that although it seems that religion has no significant effect on multinational companies, but its internal effects such as internal and interpersonal conflicts with the type of activity of companies may be intensified. Moreover, these effects would be different based on the department of individual employees. For example, when the religious orientations of Muslims increase, their activities, according to the type of the product or service provided, in marketing sector of multinational companies may be affected. As the products and services offered would have more moral dimensions and marketing activities would be based on general moral rules, not a particular religion, we may achieve more effective results and personal and interpersonal conflicts can be reduced.

McArdle disease with rhabdomyolysis induced by rosuvastatin: case report Doença de McArdle com rabdomiólise induzida por rosuvastatina: relato de caso

Directory of Open Access Journals (Sweden)

Paulo José Lorenzoni

2007-09-01

Full Text Available The rosuvastatin inducing rhabdomyolysis in McArdle disease (MD has not been reported to date. A 35-years-old man had exercise intolerance, muscular fatigue and cramps during physical activity since infancy. He presented severe rhabdomyolysis episode with seizure and coma after use of rosuvastatin. The investigation showed increased serum creatinekinase levels and the forearm ischemic exercise did not increased venous lactate. The muscle biopsy showed subsarcolemmal and central acummulation of glycogen and absence of the myophosphorylase enzyme. The statin induced myopathy is discussed and the danger of its use in MD is emphasized.Rosuvastatina induzindo rabdomiólise na doença de McArdle (MD não foi relatada até o momento. Descrevemos o caso de um homem de 35 anos que desde a infância apresentava sintomas de intolerância aos exercícios, fadiga muscular e cãibras durante o esforço físico, porém após o uso de rosuvastatina apresentou episódio de rabdomiólise com crises convulsivas e coma. A investigação mostrou creatinoquinase sérica elevada e teste do esforço isquêmico sem aumento no lactato venoso. A biópsia muscular revelou acúmulo central e subsarcolemal de glicogênio nas fibras e ausência da enzima miofosforilase. Discutimos as estatinas induzindo miopatia, enfatizando o risco do seu uso na MD.

Resource allocations, knowledge network characteristics and entrepreneurial orientation of multinational corporations

NARCIS (Netherlands)

Williams, C.; Lee, S.H.

2009-01-01

This paper analyses entrepreneurial orientation (EO) in multinational corporations (MNCs) and develops a new typology of MNC EO based on combining R&D and asset growth investment intensities as orthogonal resource allocations. A cluster analysis of US MNCs on these two dimensions reveals three types

Global Standardization or National Differentiation of HRM Practices in Multinational Companies?

DEFF Research Database (Denmark)

Edwards, Tony; Sanchez-Mangas, Rocio; Jalette, Patrice

2016-01-01

Drawing on a dataset constructed from a parallel series of nationally representative surveys of multinational companies (MNCs), we compare the performance management (PM) practices of MNCs in the UK, Ireland, Canada, Spain, Denmark and Norway. In each country we analyze data relating to MNCs from...

International transfer of employee-oriented CSR practices by multinational SME’s

NARCIS (Netherlands)

de Jong, Dirk Johan

2009-01-01

Will multinational SMEs use internationalisation to achieve labour cost savings at the expense of employees both in their home country and abroad or will they transfer their existing employee-oriented practices to their foreign subsidiaries? This paper argues that the answer to this question is

'Cloud computing' and clinical trials: report from an ECRIN workshop.

Science.gov (United States)

Ohmann, Christian; Canham, Steve; Danielyan, Edgar; Robertshaw, Steve; Legré, Yannick; Clivio, Luca; Demotes, Jacques

2015-07-29

Growing use of cloud computing in clinical trials prompted the European Clinical Research Infrastructures Network, a European non-profit organisation established to support multinational clinical research, to organise a one-day workshop on the topic to clarify potential benefits and risks. The issues that arose in that workshop are summarised and include the following: the nature of cloud computing and the cloud computing industry; the risks in using cloud computing services now; the lack of explicit guidance on this subject, both generally and with reference to clinical trials; and some possible ways of reducing risks. There was particular interest in developing and using a European 'community cloud' specifically for academic clinical trial data. It was recognised that the day-long workshop was only the start of an ongoing process. Future discussion needs to include clarification of trial-specific regulatory requirements for cloud computing and involve representatives from the relevant regulatory bodies.

Multinational corporations and infectious disease: Embracing human rights management techniques.

Science.gov (United States)

Salcito, Kendyl; Singer, Burton H; Weiss, Mitchell G; Winkler, Mirko S; Krieger, Gary R; Wielga, Mark; Utzinger, Jürg

2014-01-01

Global health institutions have called for governments, international organisations and health practitioners to employ a human rights-based approach to infectious diseases. The motivation for a human rights approach is clear: poverty and inequality create conditions for infectious diseases to thrive, and the diseases, in turn, interact with social-ecological systems to promulgate poverty, inequity and indignity. Governments and intergovernmental organisations should be concerned with the control and elimination of these diseases, as widespread infections delay economic growth and contribute to higher healthcare costs and slower processes for realising universal human rights. These social determinants and economic outcomes associated with infectious diseases should interest multinational companies, partly because they have bearing on corporate productivity and, increasingly, because new global norms impose on companies a responsibility to respect human rights, including the right to health. We reviewed historical and recent developments at the interface of infectious diseases, human rights and multinational corporations. Our investigation was supplemented with field-level insights at corporate capital projects that were developed in areas of high endemicity of infectious diseases, which embraced rights-based disease control strategies. Experience and literature provide a longstanding business case and an emerging social responsibility case for corporations to apply a human rights approach to health programmes at global operations. Indeed, in an increasingly globalised and interconnected world, multinational corporations have an interest, and an important role to play, in advancing rights-based control strategies for infectious diseases. There are new opportunities for governments and international health agencies to enlist corporate business actors in disease control and elimination strategies. Guidance offered by the United Nations in 2011 that is widely embraced

Theory of multinationals' choice of technique and locational decisions

Energy Technology Data Exchange (ETDEWEB)

de Meza, D.

1979-01-01

A neoclassical explanation is presented of the failure of multinational corporations (MNCs) to adapt their technology in low-wage countries. MNCs are found to employ more labor-intensive techniques and pay lower wages than companies serving only domestic markets if transport and tariff costs are present. Product locational decisions are also analyzed. 6 references.

Evaluating Organizational Change at a Multinational Transportation Corporation: Method and Reflections

Science.gov (United States)

Plakhotnik, Maria S.

2016-01-01

The purpose of this perspective on practice is to share my experience conducting an organizational change evaluation using qualitative methodology at a multinational transportation company Global Logistics. I provide a detailed description of the three phase approach to data analysis and my reflections on the process.

The Rights of Multinationals in the Global Transparency Framework : McCarthyism?

NARCIS (Netherlands)

Mosquera, Valderrama I.J.

2016-01-01

The overall aim of this article is to analyse the rights of corporations (mainly multinationals) when dealing with tax authorities in this new era of transparency and “fair share”. The article addresses two questions: First, what are the rights and obligations of corporations as taxpayers in

Subsidiary Performance in Multinational Corporations

DEFF Research Database (Denmark)

Andersson, Ulf; Forsgren, Mats; Pedersen, Torben

2001-01-01

are then tested in a LISREL model based on data concerning 98 subsidiaries belonging to Swedish MNCs. Our empirical results indicate that technology embeddedness has a positive, direct, impact on subsidiary market performance, and a positive, but indirect, impact on subsidiary organizational performance.......Subsidiaries have access to different types of resources and therefore perform differently in their market-place and within a multinational corporation (MNC). Yet, even though subsidiaries are the object of intense interest, remarkably little has been written about the assessment of subsidiary...... performance. In short, the strategic opportunities of subsidiaries seem to generate more attention in the literature than their results. The two distinctive features of this paper are the development of the concept of subsidiary performance and the exploration of the linkage between subsidiary business...

Financialization and the Multinational Corporation

DEFF Research Database (Denmark)

Morgan, Glenn

2014-01-01

The terrain on which states, trade unions and social movements confront multinational corporations has changed dramatically over the last two decades as a result of two phenomena – the disaggregation of the supply chain and the financialization of corporations. Trade unions and social movements...... have increasingly challenged the inequalities and unfairnesses which have emerged from the globalization of supply chains. However, issues of financialization, although increasingly high profile since 2008, have generally been treated separately. This article argues that the two phenomena...... are integrally related within the same process of neoliberal globalization. It argues that trade unions and social movements need to connect together issues to do with the relocation and restructuring of employment with issues of financialization and the need for financial reform. Change will only be effective...

RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE TREATMENT OF PATIENTS WITH SEPSIS SYNDROME - RESULTS FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

NARCIS (Netherlands)

FISHER, C. J.; DHAINAUT, J. F. A.; Opal, S. M.; Pribble, J. P.; BALK, R. A.; SLOTMAN, G. J.; IBERTI, T. J.; RACKOW, E. C.; SHAPIRO, M. J.; GREENMAN, R. L.; REINES, H. D.; SHELLY, M. P.; THOMPSON, B. W.; LABRECQUE, J. F.; Catalano, M. A.; KNAUS, W. A.; Sadoff, J. C.; ASTIZ, M.; CARPATI, C.; BONE, R. C.; FREIDMAN, B.; MURE, A. J.; BRATHWAITE, C.; SHAPIRO, E.; MELHORN, L.; TAYLOR, R.; KEEGAN, M.; OBRIEN, J.; SCHEIN, R.; PENA, M.; WASSERLOUF, M.; OROPELLO, J.; BENJAMIN, E.; DELGUIDICE, R.; EMMANUEL, G.; LIE, T.; Anderson, L.; Marshall, J.; DEMAJO, W.; ROTSTEIN, O.; FOSTER, D.; Abraham, E.; MIDDLETON, H.; Perry, C.; LEVY, H.; FRY, D. E.; SIMPSON, S. Q.; CROWELL, R. E.; Neidhart, M.; Stevens, D.; COFFMAN, T.; NARASIMHAM, N.; MERRICK, D. K.; BERGQUIST, W.; MATZEL, K. E.; HUEBLER, M.; Foulke, G. E.; ALBERTSON, T. E.; WALBY, W. F.; ALLEN, R. P.; Baughman, R.; HASSELGREN, P. O.; Fink, M. P.; FAVORITO, F.; THOMPSON, B. T.; CORBIN, R.; SHELLHORSE, G. Y.; FRAZIER, A.; White, S.; GARRARD, C.; ACOURT, C.; STORER, S.; GERVICH, D. H.; FOSHE, D.; BRASE, R.; BAGDAHN, A.; COONEY, R.; Smith, J. S.; MARTIN, L. F.; Vincent, J. L.; Friedman, G.; Berlot, G.; FLETCHER, J. R.; WILLIAMS, M. D.; WRIGHT, T. F.; Johnson, S.; FEILD, C.; WOLF, K.; MACINTYRE, N.; DUBIN, H. G.; DURKIN, M. R.; DUBIN, P. K.; STAUBACH, K. H.; FEIN, A. M.; SCHULMAN, D. B.; NIEDERMAN, M. S.; CHALFIN, D. B.; van Leeuwen, P. A. M.; Boermeester, M. A.; Schneider, A. J.; BANDER, J.; IMM, A.; BERNARD, G.; Nelson, L.; Stroud, M.; SAFCSAK, K.; CERRA, F.; RINDAL, J.; Mann, H.; HALPERN, N.; SILVERSTEIN, J.; ALICEA, M.; Sibbald, W. J.; MARTIN, C. M.; RUTLEDGE, F. S.; PETTI, K.; RUSSELL, J. A.; KRUGER, R.; DRUMMOND, A.; LANGE, P.; SEIFERT, T.; DUROCHER, A.; TENAILLON, A.; BOITEAU, R.; LHERM, T.; Lowry, S. F.; Coyle, S. M.; Barie, P. S.; DEMARIA, E.; SNYDMAN, D. R.; SCHWAITZBERG, S. D.; NASRAWAY, S. A.; GRINDLINGER, J.; SUMMER, W.; DEBOISBLANC, B.; WAHL, M.; ALESTIG, K.; GROSSMAN, J.; MAKI, D.; PAZ, H. L.; Weiner, M.; BIHARI, D.; Campbell, D.; BLEICHNER, G.; DAHN, M. S.; LANGE, M. P. A.; Hall, J.; POHLMAN, A.; WENZEL, R. P.; GROSSERODE, M.; COSTIGAN, M.; MILESKI, W.; WEIGELT, J.; YESTON, N.; IRIZARRY, C.; Ross, J.; ROBBINS, J.; NIGHTINGALE, P.; OWEN, K.; SANDSTEDT, S.; Berg, S.; SIMON, G. L.; SENEFF, M. G.; CONRY, K. M.; ZIMMERMAN, J. L.; Dellinger, R. P.; Johnston, R.; ALLEE, P.; GRANDE, P. O.; MYHRE, E.; DHAINAUT, J. F.; HAMY, I.; Mira, J. P.; HARMON, J.; White, J.; MCKIE, L.; SILVERMAN, H.; TUMA, P.; Bennett, D.; PORTER, J. C.; LAURELL, M. H.; Jacobs, S.; ASH, S.; Stiles, D. M.; PRIOR, M. J.; KNATTERUD, G.; TERRIN, M.; KUFERA, J.; WILKENS, P.; RA, K.; MONROE, L.; SPRUNG, C.; HAMILTON, C. M.; MATTHAY, R.; MCCABE, W.; TONASCIA, J.; WIEDEMAN, H.; Wittes, J.; CAMPION, G. V.; CROFT, C. R.; LUSTICK, R.; LOOKABAUGH, J.; GORDON, G. S.; NOE, L.; BLOEDOW, D.; SMITH, C. G.; BRANNON, D.; KUSH, R.; NG, D.; MOORE, E.; BAZEMORE, K.; GALVAN, M.; Wagner, D.; HARRELL, F.; STABLEIN, D.

1994-01-01

Objective.-To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhlL-1ra) in the treatment of sepsis syndrome. Study Design.-Randomized, double-blind, placebo-controlled, multicenter, multinational clinical trial. Population.-A total of 893 patients with

The Role of Home Country Political Resources for Brazilian Multinational Companies

Directory of Open Access Journals (Sweden)

Karina Regina Vieira Bazuchi

2013-10-01

Full Text Available This paper aims to analyze the interactions between home country governments and Developing Country Multinational Companies (DMNCs. Drawing on evidence from the Brazilian political environment and Brazilian multinationals we investigate the mechanisms governments use to influence the internationalization process of domestic companies and firms’ political strategic responses to shape the political institutional environment in which they operate. We argue that foreign direct investment (FDI outflows from developing economies need to be explored given specific country level contextual factors, such as high levels of government involvement. Our main findings support this idea and indicate that home country governments use a series of formal and informal mechanisms in order to drive the international expansion of DMNCs in both the entry and consolidation phases. Moreover, DMNCs political behavior in the home country political environment accounts for an important part of their strategy to develop political resources and obtain above average returns from governmental benefits.

Correlation between Sales of Foreign Affiliates and Productivity of Multinational Firms: Evidence from Korean Firm-Level Data

Directory of Open Access Journals (Sweden)

Jung Hur

2013-09-01

Full Text Available Using firm-level panel data for Korean multinational enterprises (MNEs, we make a distinction between being the only affiliate of a parent firm and being one of the multiple affiliates of a parent firm. In particular, we attempt to find a correlation between the sales of foreign affiliates and the productivity of multinational firms. Our main empirical results in this paper suggest that productive Korean MNEs would enlarge the number of affiliates in the host country.

MDEP Technical Report TR-VICWG-04. Technical Report: Assessment of Multinational Vendor Inspection of Valinox Nuclear

International Nuclear Information System (INIS)

2015-01-01

From July 7-11, 2014, the NRC led a team of inspectors representing regulators from France, the United Kingdom, and the United States in performing the first Multinational Design Evaluation Program (MDEP) multinational inspection at Valinox Nuclear in Montbard, France. Valinox Nuclear's primary product line is steam generator tubes for the nuclear industry. The purpose of the inspection was to assess Valinox's compliance with the quality assurance/quality control (QA/QM) criteria described in the Multinational Design Evaluation Program (MDEP) Vendor Inspection Cooperation Working Group (VICWG) Technical Report, TR-VICWG-03, 'Common QA/QM Criteria for Multinational Vendor Inspection', Revision 1, dated January 20, 2014, and MDEP Protocol, VICWG-01, 'Witnessed, Joint, and Multinational Vendor Inspection Protocol', Revision 2, dated March 20, 2014, respectively. The inspection also offered the inspectors an opportunity to pilot the VICWG draft common position document to gain valuable insights into the effectiveness of application of the common QA/QM criteria to vendor inspections performed by a multinational inspection team. During this inspection, the inspection team evaluated implementation of Valinox's quality assurance (QA) program with respect to 15 specific criteria: 1. Quality management system; 2. Grading; 3. Documentation of the quality management system; 4. Control of documents and records; 5. Responsibility and Leadership; 6. Human resources; 7. Process Implementation; 8. Control of planning and implementation changes; 9. Purchasing (including aspects of CSFI); 10. Control of implementation including Control of special processes; 11. Monitoring and measurement of product and service; 12. Assessment; 13. Non-conformances; 14. Corrective and preventive actions; and 15. Safety culture. By letter dated 26 August 2014, the NRC issued a vendor inspection report to Valinox Nuclear, which documented four findings (Non

Effects of rosuvastatin on progression of stenosis in adult patients with congenital aortic stenosis (PROCAS Trial)

NARCIS (Netherlands)

Linde, D. van der; Yap, S.C.; Dijk, A.P. van; Budts, W.; Pieper, P.G.; Burgh, P.H. van der; Mulder, B.J.; Witsenburg, M.; Cuypers, J.A.; Lindemans, J.; Takkenberg, J.J.; Roos-Hesselink, J.W.

2011-01-01

Recent trials have failed to show that statin therapy halts the progression of calcific aortic stenosis (AS). We hypothesized that statin therapy in younger patients with congenital AS would be more beneficial, because the valve is less calcified. In the present double-blind, placebo-controlled

Level of Harmonization and ERP Architecture in Multinational Corporations

DEFF Research Database (Denmark)

Rahimi, Fatemeh; Møller, Charles

2013-01-01

multinational corporations. The ERP distribution decision in MNCs has been mainly associated with the corporate strategy and governance structure. As global ERP deployment benefits mainly come from business consolidation, and as there are significant costs and risks associated with centralized ERP...... to be more directly affected by the factors prohibiting further divergence, namely the corporate business process governance structure and the degree of similarity of its business models....

MULTI-NATIONAL COMPANIES AND TRANSITION COUNTRIES: A MACEDONIAN EXPERIENCE

OpenAIRE

Aleksandra Patoska; Branko Dimeski

2015-01-01

The process of globalization and liberalization is further accelerated by the growing expansion of multinational companies in post-communist transition countries. Transition countries improve their technological development, increase the exports and gain better access to global markets. On other hand, global companies maximize their profits by employing cheaper resources, paying lower taxes and using a number of benefits that the transition countries offer to them. The main purpose of the pap...

Mobile advertising adoption by multinationals: Senior executives' initial responses

OpenAIRE

Okazaki, Shintaro

2005-01-01

Purpose - Although the wireless internet attracts more and more interest from marketers and researchers, there is little empirical evidence of multinational corporations' (MNCs) adoption of pulltype mobile advertising in global markets. The aim of this study is to fill this research gap, by conducting an empirical survey of the perceptions of MNCs operating in Europe regarding SMSbased mobile advertising adoption. Design/methodology/approach - The study proposes six basic const...

Commentary : Why and how can Multinational Enterprises be value-creating organizations?

NARCIS (Netherlands)

Hennart, Jean-Francois

2015-01-01

Rugman made the valid point that Multinational Enterprises are value-creating organizations but in this piece I question his explanation of why this is the case. I argue that it is not, as Rugman proposed, because MNEs are better at safeguarding their firm-specific advantages (FSAs) but because

The Role of Language in National and Multinational Enterprises in Taiwan.

Science.gov (United States)

Du-Babcock, Bertha; Babcock, Richard D.

Communication patterns and language use in four national and multinational companies operating in Taiwan illustrate the potential for communication problems when more than one language is in use. The companies include Texas Instruments, Kaohsiung Monomer Company, Ltd., Bank of America, and Cheng-Yia International Corporation. In the four…

Multinational banks and the global financial crisis : Weathering the perfect storm?

NARCIS (Netherlands)

de Haas, R.; van Lelyveld, I.

We use data on the 48 largest multinational banking groups to compare the lending of their 199 foreign subsidiaries during the Great Recession with lending by a benchmark of 202 domestic banks. Contrary to earlier and more contained crises, parent banks were not a significant source of strength to

An Assessment of E-Training Effectiveness in Multinational Companies in Malaysia

Science.gov (United States)

Ramayah, Thurasamy; Ahmad, Noor Hazlina; Hong, Tan Say

2012-01-01

E-training has developed into a revolutionary way of learning in Malaysian organizations due to rapid growth in information technology infrastructure. The present study endeavors to determine the critical factors that influence e-training effectiveness in multinational companies (MNCs) in Malaysia. By integrating Technology Acceptance Model (TAM),…

Multinational study exploring patients' perceptions of side-effects induced by chemo-radiotherapy

DEFF Research Database (Denmark)

Ruhlmann, Christina H; Iversen, Trine Zeeberg; Okera, Meena

2015-01-01

PURPOSE: We aimed to prospectively assess the incidence, severity and patients' perceptions of side-effects induced by radiotherapy and concomitant weekly cisplatin. PATIENTS AND METHODS: This multinational survey included patients with a diagnosis of gynaecological or head and neck cancer schedu...

Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings.

Directory of Open Access Journals (Sweden)

Thomas B Campbell

Full Text Available Antiretroviral regimens with simplified dosing and better safety are needed to maximize the efficiency of antiretroviral delivery in resource-limited settings. We investigated the efficacy and safety of antiretroviral regimens with once-daily compared to twice-daily dosing in diverse areas of the world.1,571 HIV-1-infected persons (47% women from nine countries in four continents were assigned with equal probability to open-label antiretroviral therapy with efavirenz plus lamivudine-zidovudine (EFV+3TC-ZDV, atazanavir plus didanosine-EC plus emtricitabine (ATV+DDI+FTC, or efavirenz plus emtricitabine-tenofovir-disoproxil fumarate (DF (EFV+FTC-TDF. ATV+DDI+FTC and EFV+FTC-TDF were hypothesized to be non-inferior to EFV+3TC-ZDV if the upper one-sided 95% confidence bound for the hazard ratio (HR was ≤1.35 when 30% of participants had treatment failure. An independent monitoring board recommended stopping study follow-up prior to accumulation of 472 treatment failures. Comparing EFV+FTC-TDF to EFV+3TC-ZDV, during a median 184 wk of follow-up there were 95 treatment failures (18% among 526 participants versus 98 failures among 519 participants (19%; HR 0.95, 95% CI 0.72-1.27; p = 0.74. Safety endpoints occurred in 243 (46% participants assigned to EFV+FTC-TDF versus 313 (60% assigned to EFV+3TC-ZDV (HR 0.64, CI 0.54-0.76; p<0.001 and there was a significant interaction between sex and regimen safety (HR 0.50, CI 0.39-0.64 for women; HR 0.79, CI 0.62-1.00 for men; p = 0.01. Comparing ATV+DDI+FTC to EFV+3TC-ZDV, during a median follow-up of 81 wk there were 108 failures (21% among 526 participants assigned to ATV+DDI+FTC and 76 (15% among 519 participants assigned to EFV+3TC-ZDV (HR 1.51, CI 1.12-2.04; p = 0.007.EFV+FTC-TDF had similar high efficacy compared to EFV+3TC-ZDV in this trial population, recruited in diverse multinational settings. Superior safety, especially in HIV-1-infected women, and once-daily dosing of EFV+FTC-TDF are

Role of Multinational Corporations in Automobile Industries: A Comparative Study Between India and Mexico

Directory of Open Access Journals (Sweden)

Ganesh Babu Kumaran

2008-10-01

Full Text Available Role of Multinational Corporations ( MNC’s in developing countries is not new in the arena of International business and global macroeconomics. One of the most significant economic developments of recent decades is the economic LPG process (Liberalisation, Privatisation and Globalisation is reflected in the rapid growth in international trade and the surge in Foreign Direct Investment (FDI. This process is to a large extent driven by new investments from multinational corporations. A rapidly growing share of MNC’s in India and Mexico in last decade was evident in various sector and in particular to automobile sector. Multinational Corporations are seeking to exploit the vast but also precarious market potentials in these emerging economies. Simultaneously, India and Mexico are increasingly embarking on economic development strategies aimed at attracting MNC’s Foreign Direct Investment as a means to access technology, capital, organizational and marketing know how, etc. This study does comparative analyses on the performance of automobile sector in India and Mexico, mainly in passenger car and Utility vehicles sector. It examines the impact and the role of MNC’s in these economies since 1990’s, with derived empirical quantitative and qualitative data analysis that would illustrate and reinforce some of the contemporary status.

The Features of Transformation of Multinational Enterprises in Conditions of Influence of External Environment

Directory of Open Access Journals (Sweden)

Petrenko Viktoriia S.

2018-03-01

Full Text Available The regularities of transforming the environment of multinational enterprises are considered from the standpoint of the general system theory. Tendencies of growth of pressure of the international competition on the Ukrainian branch markets have been identified. Special attention is paid to the nature of interaction between global and local forces that determine the type of operating environment. On the basis of the allocated nine main directions of transformational processes at the enterprise, the matrix of decision-making on ways of integration of the enterprise in business space has been proposed. Attention is focused on the problem of the local and the global, which is manifested in the decisions on standardization and adaptation of strategies. The dependence of degree of adaptation and standardization of strategic decisions from the correlation of local and global factors of environment, from the type of environment, in which a multinational enterprise works, has been characterized. The national and international aspects of both the internal networks and the external cooperation agreements, advantages of the joint innovative efforts in the form of cooperation are researched. The international importance of multinational enterprises is very topical, as the interaction between own capital and external sources increases the innovation potential of enterprises.

Using Internet Resources in Teaching Financial Reporting and Analysis of Multinational Enterprises.

Science.gov (United States)

Agami, Abdel M.

2003-01-01

Provides some sources of corporate financial information on the Internet and illustrates how to use these resources in teaching international business and, more specifically, financial reporting and analysis of multinational enterprises. Points out some of the advantages and limitations of these resources. (EV)

The impact of institutional hazards on foreign multinational activity : A contingency perspective

NARCIS (Netherlands)

Slangen, Arjen H. L.; Beugelsdijk, Sjoerd

Prior studies have shown that institutional hazards in the form of formal governance deficiencies and informal cultural distance are both negatively related to the amount of foreign multinational activity in countries. We argue that the strength of these negative relationships varies systematically

Global Talent Management in Multinational Corporations and the Role of Social Networks

NARCIS (Netherlands)

Ruel, Hubertus Johannes Maria; Bondarouk, Tatiana; Dresselhaus, Lena; Olivas-Lujan, M.R.; Bondarouk, T.V.

2013-01-01

Purpose — Current global business challenges and circumstances are responsible for the need for global talent management (GTM) within multinational corporations (MNCs). Social media and networks are becoming key channels for global communication and collaboration. For GTM in MNCs, an effective usage

Generation of polyclonal antibody with high avidity to rosuvastatin and its use in development of highly sensitive ELISA for determination of rosuvastatin in plasma

Directory of Open Access Journals (Sweden)

Al-Malaq Hamoud A

2011-07-01

Full Text Available Abstract In this study, a polyclonal antibody with high avidity and specificity to the potent hypocholesterolaemic agent rosuvastatin (ROS has been prepared and used in the development of highly sensitive enzyme-linked immunosorbent assay (ELISA for determination of ROS in plasma. ROS was coupled to keyhole limpt hemocyanin (KLH and bovine serum albumin (BSA using carbodiimide reagent. ROS-KLH conjugate was used for immunization of female 8-weeks old New Zealand white rabbits. The immune response of the rabbits was monitored by direct ELISA using ROS-BSA immobilized onto microwell plates as a solid phase. The rabbit that showed the highest antibody titer and avidity to ROS was scarified and its sera were collected. The IgG fraction was isolated and purified by avidity chromatography on protein A column. The purified antibody showed high avidity to ROS; IC50 = 0.4 ng/ml. The specificity of the antibody for ROS was evaluated by indirect ELISA using various competitors from the ROS-structural analogues and the therapeutic agents used with ROS in a combination therapy. The proposed ELISA involved a competitive binding reaction between ROS, in plasma sample, and the immobilized ROS-BSA for the binding sites on a limited amount of the anti-ROS antibody. The bound anti-ROS antibody was quantified with horseradish peroxidase-labeled second anti-rabbit IgG antibody (HRP-IgG and 3,3',5,5'-tetramethylbenzidine (TMB as a substrate for the peroxidase enzyme. The concentration of ROS in the sample was quantified by its ability to inhibit the binding of the anti-ROS antibody to the immobilized ROS-BSA and subsequently the color intensity in the assay wells. The assay enabled the determination of ROS in plasma at concentrations as low as 40 pg/ml.

Clinical trials for vaccine development in registry of Korea Food and Drug Administration.

Science.gov (United States)

Kang, Seog-Youn

2013-01-01

Based on the action plan "Ensuring a stable supply of National Immunization Program vaccines and sovereignty of biopharmaceutical products," Korea Food and Drug Administration (KFDA) has made efforts to develop vaccines in the context of self reliance and to protect public health. Along with the recognized infrastructures for clinical trials, clinical trials for vaccines have also gradually been conducted at multinational sites as well as at local sites. KFDA will support to expand six to eleven kinds of vaccines by 2017. In accordance with integrated regulatory system, KFDA has promoted clinical trials, established national lot release procedure, and strengthened good manufacturing practices inspection and post marketing surveillance. Against this backdrop, KFDA will support the vaccine development and promote excellent public health protection.

Knowledge Transfer and Accommodation Effects in Multinational Corporations

DEFF Research Database (Denmark)

Geisler Asmussen, Christian; Foss, Nicolai J.; Pedersen, Torben

2013-01-01

Foreign subsidiaries in multinational corporations (MNCs) possess knowledge that has different sources (e.g., the firm itself or various sources in the environment). How such sources influence knowledge transfer is not well understood. Drawing on the "accommodation effect" from cognitive psychology...... if a certain tipping point of internally sourced knowledge has been surpassed. This suggests that subsidiary knowledge stocks that are balanced in terms of their origins tend to be more valuable, congruous, and fungible, and therefore more likely to be transferred to other MNC units...

Pierre Moscovici:"Nieuwe belasting multinationals moet voor verkiezingen"

OpenAIRE

Roels, Frank

2018-01-01

Pierre Moscovici, the European Commissioner for economy and taxation, met in Brussels with representatives of the S&D fraction in de European Parliament, and of the European Trade Unions. All want the Member States to approve a novel temporary tax on big internet multinationals such as Apple, fB, Google, Amazon; and this before the EP elections of 2019. The number of customers and income from advertisements will be used as tax base. Paul Tang, MEP for the PvdA (NL), is leading the campaign a...

HRM and IR in Multinational Corporations in Denmark

DEFF Research Database (Denmark)

Navrbjerg, Steen Erik; Minbaeva, Dana

2009-01-01

As multinational corporations operate in multiple countries, headquarters must take into account differences in local settings when seeking the means to coordinate and control subsidiaries. The local system of industrial relations sets the framework for what kind of human resource management......, that a shift from a stakeholder to a shareholder management style and an increased degree of HQ control have an effect on the whole cooperative atmosphere in each of the companies. In the long run, they may affect the collective bargaining system as such....

A Strategic Risk Management Framework for Multinational Enterprise

DEFF Research Database (Denmark)

Juul Andersen, Torben

2005-01-01

and economic risks that can be monitored within conventional reporting systems and managed through use of various derivative instruments. All the while, a dispersed multinational structure can be vulnerable to disruptions caused by changing economic conditions, competitive moves, and geopolitical developments......-frequency high-impact disaster events based on scenario analyses. Hence, there is a need to consider risk management approaches that integrate relatively transparent financial exposures with the consequences of uncertain and hard-to-quantify event risks. This paper outlines the contours of such a strategic risk...

Global Account Management for Sales Organization in Multinational Companies

OpenAIRE

Canegrati, Tino

2009-01-01

A Global Company is not just a Multinational Company, but on top it has developed an organizational structure, an overall governance and a set of operational decision making processes which allow running a significant percentage of business processes as a unique body across borders. Successful Global Companies have a clear setup and governance of local versus centralized decision making processes, as well as budget ownership. Corporations focused on global opportunities need to re-think their...

Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.

Science.gov (United States)

Edwards, Jeffrey E; Eliot, Lise; Parkinson, Andrew; Karan, Sharon; MacConell, Leigh

2017-09-01

Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug-drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters. Five phase 1 single-center, open-label, fixed-sequence, inpatient studies were conducted in healthy adult subjects to evaluate the effect of oral daily doses of 10 or 25 mg OCA on single-dose plasma pharmacokinetics of specific probe substrates for enzymes CYP1A2 (caffeine, R-warfarin), CYP3A (midazolam, R-warfarin), CYP2C9 (S-warfarin), CYP2D6 (dextromethorphan), CYP2C19 (omeprazole), and drug transporters, BCRP/OATP1B1/OATP1B3 (rosuvastatin), and P-gp (digoxin). OCA showed no substantial suppression/inhibition of S-warfarin, digoxin, and dextromethorphan and weak interactions with caffeine, omeprazole, rosuvastatin, and midazolam. The maximal pharmacodynamic responses (E max ) to warfarin-based INR, PT, and aPTT were reduced by 11%, 11%, and 1%, respectively, for the 10-mg dose group and by 7%, 7% and 0%, respectively, for the 25-mg dose group. Overall, drugs dosed in combination with OCA were well tolerated, and most adverse events were mild in severity. No clinically important trends were noted in laboratory evaluations, vital signs, or 12-lead ECGs. In these studies, OCA showed weak to no suppression/inhibition of metabolic enzymes and drug transporters at the highest recommended therapeutic dose in patients with PBC. On the basis on these analyses, monitoring and maintenance of target INR range are required during coadministration of OCA with drugs that are metabolized by CYP1A2 (R-warfarin). Intercept Pharmaceuticals, Inc.

Critical Success Factors: How One Multinational Company Develops Global E-Learning

Science.gov (United States)

Nathan, Edward Pavel

2011-01-01

This research study examined how a multinational company determined what the critical success factors (CSFs) were for developing global e-learning. The study analyzed how these CSFs were grouped together to make their management more efficient. There were 21 participants in the study who were key stakeholders from the United States, Europe, Latin…

Multinational corporations and health care in the United States and Latin America: strategies, actions, and effects.

Science.gov (United States)

Jasso-Aguilar, Rebeca; Waitzkin, Howard; Landwehr, Angela

2004-01-01

In this article we analyze the corporate dominance of health care in the United States and the dynamics that have motivated the international expansion of multinational health care corporations, especially to Latin America. We identify the strategies, actions, and effects of multinational corporations in health care delivery and public health policies. Our methods have included systematic bibliographical research and in-depth interviews in the United States, Mexico, and Brazil. Influenced by public policy makers in the United States, such organizations as the World Bank, International Monetary Fund, and World Trade Organization have advocated policies that encourage reduction and privatization of health care and public health services previously provided in the public sector. Multinational managed care organizations have entered managed care markets in several Latin American countries at the same time as they were withdrawing from managed care activities in Medicaid and Medicare within the United States. Corporate strategies have culminated in a marked expansion of corporations' access to social security and related public sector funds for the support of privatized health services. International financial institutions and multinational corporations have influenced reforms that, while favorable to corporate interests, have worsened access to needed services and have strained the remaining public sector institutions. A theoretical approach to these problems emphasizes the falling rate of profit as an economic motivation of corporate actions, silent reform, and the subordination of polity to economy. Praxis to address these problems involves opposition to policies that enhance corporate interests while reducing public sector services, as well as alternative models that emphasize a strengthened public sector

The Role of Subsidiaries in Emerging Markets in Generating Competitive Advantages for Foreign Multinationals: the case of the Brazilian subsidiary of Clarks International

Directory of Open Access Journals (Sweden)

Marcelo André Machado

2014-07-01

Full Text Available The relationship between a multinational and its subsidiaries abroad, according to many studies, is crucial for generating competitive advantages. Therefore, this study aimed to understand the relationship between a shoe company, Clarks International, and its Brazilian subsidiary with an emphasis on generating advantages to the multinational headquarters. Through a single case study, the subsidiary’s capacity for knowledge generation and diffusion was identified, as well as its level of autonomy in relation to the English headquarters. Data analysis indicated that the Brazilian subsidiary generated specific competitive advantages for the foreign multinational due to its close relationship with local suppliers in Brazil and due to its staff’s expertise in developing high quality shoes. It was perceived that the growth of subsidiary autonomy was related to the growth of specific advantages generated for the multinational.

Relevance of Intelsat experience for organizational structure of multinational nuclear fuel facilities

International Nuclear Information System (INIS)

Skolnikoff, E.B.

1977-01-01

The multinational fuel centers will be a much more difficult development than creating an international organization for communications satellites, but there are obvious parallels that can be used or avoided. The relative success and effectiveness of Intelsat gives hope that the task can be achieved

Strategic R&D location by multinational firms : spillovers, technology sourcing, and competition

NARCIS (Netherlands)

Belderbos, R.A.; Lykogianni, E.; Veugelers, R.

2005-01-01

We analyse strategic interaction in R&D internationalization decisions by two multinational firms competing both abroad and in their home markets and examine different incentives for foreign R&D faced by technology leaders and technology laggards. The model takes into account the impact of local

INTERNATIONAL MARKETING ACTIVITIES OF MULTINATIONAL COMPANIES IN CONDITIONS OF INSTABILITY

Directory of Open Access Journals (Sweden)

N. V. Lyasnikov

2016-01-01

Full Text Available This article describes the conceptual basis for the formation of international marketing, the characteristic of the main exit strategies on the world market, revealed features of international marketing that national companies are obliged to take into account the examples of international marketing strategies of international companies such as Apple, Google, Nike, the Russian company Natura Siberica.The purpose of this paper is to analyze the international marketing activities of multinational companies and the development of proposals for improving this process.Methodology. To complete this article, no such analysis methods were used as comparative and Economics and Statistics.Conclusions / relevance. The results are of practical value, they can be used in a lecture course teachers of educational institutions in the preparation of managers, as well as direct marketing specialists. In the study, the author was able to draw a number of conclusions that facilitate the development of the set of eff ective combinations, each of which represents a unique scenario of territorial expansion. Promising further expansion of the practice of implementation of marketing approaches in the organization of the entities of multinational companies, in Vol. H. The use of new technologies.

Crosscultural Issues in the Process of Sending U.S. Employees of Multinational Corporations for Overseas Service: Theoretical Considerations with Practical Implications.

Science.gov (United States)

Griffis, Betty Ann

Defining the multinational as a producing enterprise motivated by profit and owning or controlling facilities in more than one country, this paper analyzes the process employed by United States multinationals in sending parent country nationals abroad for service in a subsidiary. It first examines the process in its fullest form by citing…

Glass Ceiling in the Workplace: An Analysis within the Stated-owned Enterprises and Multi-national Enterprises in China

OpenAIRE

Cao, Mengxi

2015-01-01

Currently, although the increasingly number of women has gained leadership positions, the glass ceiling phenomenon still exists in China, especially in multi-national enterprise. In brief, the road to the upper rungs for female is still challenging and difficult. Due to the nature of the enterprises, the performance of glass ceiling is different. The aim of this dissertation is to discuss different performance and influence of glass ceiling in the context of the multi-national enterprises (MN...

Multinational Corporation and International Strategic Alliance

Institute of Scientific and Technical Information of China (English)

陆兮

2015-01-01

The world is now deeply into the second great wave of globalization, in which product, capital, and markets are becoming more and more integrated across countries. Multinational corporations are gaining their rapid growth around the globe and playing a significant role in the world economy. Meanwhile, the accelerated rate of globalization has also imposed pressures on MNCs, left them desperately seeking overseas alliances in order to remain competitive. International strategic alliances, which bring together large and commonly competitive firms for specific purposes, have gradual y shown its importance in the world market. And the form of international joint venture is now widely adopted. Then after the formation of alliances, selecting the right partner, formulating right strategies, establishing harmonious and effective partnership are generally the key to success.

Subsidiary Initiative Taking in Multinational Corporations

DEFF Research Database (Denmark)

Dörrenbacher, Christoph; Gammelgaard, Jens

2016-01-01

This paper investigates the political maneuvering that accompanies subsidiary initiative taking in multinational corporations. On the basis of an explorative empirical investigation of subsidiary initiative taking in the French subsidiaries of six German MNCs, the paper explores the activities...... that subsidiaries undertake to sell their initiatives, and the relationships among issue selling, subsidiary power and headquarters’ hierarchical power. The findings suggest that the use of issue-selling tactics is common when subsidiaries engage in initiative taking. In addition, the paper demonstrates that a low...... degree of issue selling is needed to obtain approval of an initiative in less asymmetrical headquarters–subsidiary power relationships (i.e. relationships in which subsidiaries are relatively powerful). In cases where power relationships are highly asymmetrical, issue selling is a necessity...

Variation in Approaches to European Works Councils in Multinational Companies

OpenAIRE

Paul Marginson; Jonathan Lavelle; Javier Quintanilla; Duncan Adam; Roc'o S?nchez-Mangas

2013-01-01

Drawing on a unique international data set of multinational companies' employment practices, the authors use logistic regression analysis to address variation in the existence of and management practice toward transnational social dialogue through European Works Councils (EWCs). Adopting a contingency perspective, they find that the degree of internationalization of companies' operations and management organization, international HR structure, and the presence of workforce organization exerci...

Acute hypoxemic respiratory failure in immunocompromised patients : The Efraim multinational prospective cohort study

NARCIS (Netherlands)

Azoulay, Elie; Pickkers, Peter; Soares, Marcio; Perner, Anders; Rello, Jordi; Bauer, Philippe R.; van de Louw, Andry; Hemelaar, Pleun; Lemiale, Virginie; Taccone, Fabio Silvio; Loeches, Ignacio Martin; Meyhoff, Tine Sylvest; Salluh, Jorge; Schellongowski, Peter; Rusinova, Katerina; Terzi, Nicolas; Mehta, Sangeeta; Antonelli, Massimo; Kouatchet, Achille; Barratt-Due, Andreas; Valkonen, Miia; Landburg, Precious Pearl; Bruneel, Fabrice; Bukan, Ramin Brandt; Pene, Frederic; Metaxa, Victoria; Moreau, Anne Sophie; Souppart, Virginie; Burghi, Gaston; Girault, Christophe; Silva, Ulysses V. A.; Montini, Luca; Barbier, Francois; Nielsen, Lene B.; Gaborit, Benjamin; Mokart, Djamel; Chevret, Sylvie

2017-01-01

Background: In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). Methods: To assess the impact of initial management on IMV and mortality rates, we performed a multinational observational

Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study

NARCIS (Netherlands)

Azoulay, E.; Pickkers, P.; Soares, M.; Perner, A.; Rello, J.; Bauer, P.R.; Louw, A. van de; Hemelaar, P.; Lemiale, V.; Taccone, F.S.; Loeches, I.M.; Meyhoff, T.S.; Salluh, J.; Schellongowski, P.; Rusinova, K.; Terzi, N.; Mehta, S.; Antonelli, M.; Kouatchet, A.; Barratt-Due, A.; Valkonen, M.; Landburg, P.P.; Bruneel, F.; Bukan, R.B.; Pene, F.; Metaxa, V.; Moreau, A.S.; Souppart, V.; Burghi, G.; Girault, C.; Silva, U.V.A.; Montini, L.; Barbier, F.; Nielsen, L.B.; Gaborit, B.; Mokart, D.; Chevret, S.

2017-01-01

BACKGROUND: In immunocompromised patients with acute hypoxemic respiratory failure (ARF), initial management aims primarily to avoid invasive mechanical ventilation (IMV). METHODS: To assess the impact of initial management on IMV and mortality rates, we performed a multinational observational

Intraorganizational Career Advancement and Voluntary Turnover in a Multinational Bank in Taiwan

Science.gov (United States)

Zhao, Wei; Zhou, Xueguang

2008-01-01

Purpose: This study aims to investigate how various aspects of intraorganizational career advancement--current career attainments, recent pace of upward mobility, and future prospect of career advancement--affect voluntary turnover, drawing empirical evidence from a multinational corporation (MNC) in Taiwan's cultural and labor market environment.…

Lend Global, Fund Local? Price and Funding Cost Margins in Multinational Banking

NARCIS (Netherlands)

Galema, R.; Koetter, M.; Liesegang, C.

2016-01-01

In a proposed model of a multinational bank, interest margins determine local lending by foreign affiliates and the internal funding by parent banks. We exploit detailed parent-affiliate-level data of all German banks to empirically test our theoretical predictions in pre-crisis times. Local lending

Multinational Corporations and British Labour: A Review of Attitudes and Responses.

Science.gov (United States)

Gennard, John

Multinational corporations operating in Great Britain, specifically American industry, are arousing fears on the part of British labor, which can be grouped into these categories: (1) a threat to the job security of union members, (2) a change in the balance of power at the collective bargaining table in favor of the employers, (3) a clash of…

Alliance Concentration in Multinational Companies : Examining Alliance Portfolios, Firm Structure, and Firm Performance

NARCIS (Netherlands)

Bos, Brenda; Faems, Dries; Noseleit, Florian

Research summary: This article explores the distribution of alliances across firms' internal structure. Focusing on multinational companies, we examine the impact of alliance portfolio concentrationi.e., the extent to which alliances are concentrated within a limited number of geographic unitson

Alliance Concentration in Multinational Companies : Examining Alliance Portfolios, Firm Structure, and Firm Performance

NARCIS (Netherlands)

Bos, Brenda; Faems, Dries; Noseleit, Florian

2017-01-01

Research summary: This article explores the distribution of alliances across firms' internal structure. Focusing on multinational companies, we examine the impact of alliance portfolio concentrationi.e., the extent to which alliances are concentrated within a limited number of geographic unitson

R&D activities in East Asia by Japanese, European, and US Multinationals

NARCIS (Netherlands)

Belderbos, R.A.

2006-01-01

We contribute to the expanding literature on the internationalization of R&D by providing evidence on the extent and pattern of R&D activities by European, Japanese, and US multinational firms in 10 Asian countries and regions: PR China, India, the Asian NIEs (South Korea, Taiwan, Hong Kong, and

THE MULTINATIONAL COMPANIES AND THE LOW-COST MARKETS OF SOUTH-EAST ASIA

Directory of Open Access Journals (Sweden)

Diaconu Laura

2009-05-01

Full Text Available In order to be considered a low-cost market, the cost advantage of one or more factors of production offered by a state – generally, a developing one – must be exploited by the multinational firms. Therefore, we may speak about these markets only after 19

The Case of a Newly Implemented Modern Management Accounting System in a Multinational Manufacturing Company

Directory of Open Access Journals (Sweden)

Daniel Watts

2014-06-01

Full Text Available Contemporary management accounting techniques (such as TQM, BSC, JIT are widely lauded by academia but the proposed relevance to business has not necessarily the view held by industry (e.g. Burns & Vaivio, 2001; Chenhall & Langfield-Smith, 1998; Innes et al., 2000. The purpose of this article is to investigate the acquisition by a modern multi-national firm of a major IT-based management accounting program to assess the relevance and usefulness of its functionality by identifying the type(s of systems that are utilised and the rationale for upgrading or modifying its system(s. This study relies on a single case based on two in-depth semi structured interviews with accounting and finance professionals in a multi-national manufacturing company that recently implemented a modern management accounting system. The findings indicate that despite demonstrating some relevance of the management accounting information, the manufacturer deactivated components of the system that were deemed irrelevant at particular levels of the organisation. This paper provides evidence about the non-reliance on management accounting information in a multinational company operating in Australia. The findings in the study imply that relevance is linked to implementation, planning and training will help managers to better prepare themselves in setting up contemporary management accounting systems.

Rosuvastatin in diabetic hemodialysis patients

DEFF Research Database (Denmark)

Holdaas, Hallvard; Holme, Ingar; Schmieder, Roland E

2011-01-01

A randomized, placebo-controlled trial in diabetic patients receiving hemodialysis showed no effect of atorvastatin on a composite cardiovascular endpoint, but analysis of the component cardiac endpoints suggested that atorvastatin may significantly reduce risk. Because the AURORA (A Study...

The internationalisation of Indian multinationals: determinants of expansion through acquisitions

OpenAIRE

Rienda, Laura; Claver-Cortés, Enrique; Quer, Diego

2013-01-01

In recent years, there is an increasing number of papers focusing on the internationalisation process of Indian multinationals. However, there is still a gap in understanding the determinants of their outward foreign direct investment (FDI) decisions. Thus, this paper analyses the factors influencing the choice between FDI modes by Indian firms. Our findings show that industry technological intensity, host country risk, host market attractiveness, previous international experience and the vol...

Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study

NARCIS (Netherlands)

Sondermeijer, Brigitte M.; Boekholdt, S. Matthijs; Rana, Jamal S.; Kastelein, John J. P.; Wareham, Nicholas J.; Khaw, Kay-Tee

2013-01-01

Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) has raised several points of debate. We quantified the proportion of individuals meeting the JUPITER criteria, determined their risk profile, and their risk of coronary heart disease (CHD)

THE EFFECT OF MULTINATIONAL UNDERWRITING FIRMS ON INTELLECTUAL CAPITAL DISCLOCURE IN INDONESIAN IPO PROSPECTUSES

Directory of Open Access Journals (Sweden)

Dezie L. Warganegara

2017-03-01

Full Text Available The objective of this study was to investigate the effects of multinational underwriters on intellectual capitaldisclosure in Indonesian IPO prospectuses. Intellectual capital disclosure practices were driven by the adviceof underwriters. Multinational underwriters had a greater capacity to produce more relevant information so itreduced the information gap for IPO market participants. The information included IC disclosure practices inIPO prospectuses. This study found that the nationality of underwriting firms positively affected the extent ofintellectual capital disclosure in Indonesian IPO prospectuses. Exposure to IPOs in other countries and theability to combine dispersed knowledge across their international branches seemed to have a positive effect onmulti-national underwriting firms in as much as it led to a higher standard of disclosure of intellectual capitalthan that of local underwriting firms.

A MULTINATIONAL COMPANY PROBLEM: INFILTRATING INTO THE CLUSTERS TO GAIN COMPETITIVE EDGE IN THE TRADITIONAL MARKETS

Directory of Open Access Journals (Sweden)

Murat KOC

2014-07-01

Full Text Available This paper is concerned with one of the main challenges of the Multinational Companies which they face in the traditional and thus in local markets. Multinational Companies aims to gain competitive advantage through differentiation in terms of their globalization strategy. However, in the local markets where the organic relationship of firms are more designed in local habits, and markets react with stable consumer behaviors, it gets harder to enter into market and drive a competitive edge. This paper aims to understand the reasons of this challenge, the analysis of resistance of traditional markets, successful sample breaking into local market and the strategy around it.

Drivers of the international expansion of emerging-market multinationals

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D. Boșcor

2013-06-01

Full Text Available The purpose of the present paper is to analyze the drivers of the international expansion of emerging market multinationals and the strategies applied by these companies in other emerging and developed markets. The paper applies a conceptual approach combined with analyses of statistics and secondary material and presents the company and the country specific advantages. The proposals for the Romanian companies and institutions are based on the comparison between the drivers of expansion in the BRIC countries.

A license to mine?: Community organizing against multinational corporations

OpenAIRE

Krämer, Romy

2016-01-01

textabstractWhat does it mean when a corporation claims to have a ‘license to operate’ in a local community? How does a member of an indigenous tribe make it to London to protest against a multinational mining company? How do managers perceive and speak about protest against their company and how does this discourse matter for social movement repression? First, I argue, based on a literature review, that responsiveness to local community needs has become an important factor influencing the ab...

A tale of three labels: translating the JUPITER trial data into regulatory claims.

Science.gov (United States)

Ridker, Paul M

2011-08-01

Whether a pivotal randomized trial will be interpreted in a similar and consistent manner by different regulatory agencies is uncertain as policy perspectives may play a role in data interpretation and the translation of trial results into clinical practice. Using a contemporary example, to compare and contrast regulatory claims in the United States, Europe, and Canada that derive from a pivotal clinical trial. The recently completed JUPITER trial of rosuvastatin as compared to placebo conducted among 17,802 men and women with LDL-C JUPITER trial provides an opportunity to compare and contrast how regulatory agencies in the United States, Canada, and Europe chose to interpret an identical database. Labeling indications based on earlier statin trials of primary and secondary prevention were also reviewed. JUPITER demonstrated a 44% reduction (p JUPITER trial population by stipulating that those eligible for treatment should be older men and women with hsCRP >2 mg/L, plus one additional risk factor for heart disease. The Canadian label is silent on age and hsCRP (the major trial inclusion criterion), stipulating instead that treatment can be considered for those with 'at least two conventional risk factors for cardiovascular disease,' a group more inclusive than that studied. In contrast, the European Medicines Agency label limits treatment only to 'high risk individuals' ignoring hsCRP and using instead a post hoc definition of 'high risk' that comprised a subgroup of less than 10% of the study population who contributed but 67 events to the study total and did not show statistical significance when compared to placebo. None of the regulatory labels included the trial primary endpoint; instead, each focused on separate and different components of the primary endpoint. Similar discrepancies were found between European and North American regulatory agencies with regard to earlier pivotal trials of statins for primary prevention, but not for secondary prevention. The

Social Networking as a Facilitator for Lifelong Learning in Multinational Employee’s Career

Directory of Open Access Journals (Sweden)

Andreea Nicoleta VISAN

2017-01-01

Full Text Available This paper discusses how multinational employees who are leaving in Bucharest, Romania use social networks as a tool for their everyday tasks and work, and how they want to satisfy their personal development needs by having access to information from these digital platforms. The case study described was conducted in Bucharest in 2017 and followed a results analysis with structured tables and graphs. In the study took part 24 participants who were selected among multinational IT employees in Bucharest. Social networks contribute to employee’s lifelong educational process: besides providing them positive gratification, they also contribute to their personal development and careers growth. Even though all individuals who participated in this study use social networks, more efforts should be done in order for companies in Bucharest to know the benefits of social networks and employee’s opinion about their contribution to lifelong learning.

Low-intensity conflict in multinational corporations

DEFF Research Database (Denmark)

Lauring, Jakob; Andersen, Poul Houman; Storgaard, Marianne

2017-01-01

in four Danish MNCs. Findings: They describe consequences of low-intensity conflict and identify three types of actions by headquarters’ representatives that could lead to the development of low-intensity conflicts, namely, ignoring, bypassing and educating. Originality/value: Very few studies have dealt......Purpose: This paper aims to identify antecedents for, and consequences of, low-intensity inter-unit conflict in multinational corporations (MNCs). Inter-unit conflict in MNCs is an important and well-researched theme. However, while most studies have focused on open conflict acknowledged by both...... parties, much less research has dealt with low-intensity conflicts. Still, low-intensity conflicts can be highly damaging – not least because they are rarely resolved. Design/methodology/approach: The authors used a qualitative approach to understanding low-intensity conflict relying on 170 interviews...

Human Resource Outsourcing: Lesson from Multinational Enterprises

Directory of Open Access Journals (Sweden)

Hasliza Abdul Halim

2011-03-01

Full Text Available This paper examines the consequence of the organization internalization on the practice of human resource (HR outsourcing among manufacturing organizations. The assumption is that HR outsourcing is perceived as an innovative practice and that multinational enterprise (MNEs will employ this practice more than local organizations. The data was gathered from survey questionnaires of 232 manufacturing organizations. Of the sample, 113 organizations engaged with HR outsourcing, and 71 are MNEs that partially outsource their HR functions. The findings reveal that HR outsourcing among MNEs is used to a greater extent than local organizations. A significant difference is found in the extent of outsourcing payroll, benefits, training and recruitment between MNEs and in local organizations.

European project for a multinational macrosectoral model

Energy Technology Data Exchange (ETDEWEB)

d' Alcantara, G; Italianer, A

1984-01-01

This paper describes the HERMES project, a multinational macrosectoral European econometric modelling effort, sponsored by the Directorates General II (Economic and Financial Affairs), XII (Science, Research and Development), XVII (Energy) and the SOEC. The set-up of the model is sketched against the background of problems of growth, unemployment, inflation, trade balances, government balances and energy policy. Although the definitions of the variables and a complete specification of the model are given in the Appendix, the major features of the model are described extensively in the text. These include private and collective consumption (incl. a consumer demand system), the putty-clay production process, price and wage formation, sectoral bilateral trade flows and integrated energy economy modelling.

Child labor and multinational conduct : a comparison of international business and stakeholder codes

NARCIS (Netherlands)

Kolk, A.; van Tulder, R.

2002-01-01

Increasing attention to the issue of child labor has been reflected in codes of conduct that emerged in the past decade in particular. This paper examines the way in which multinationals, business associations, governmental and non-governmental organizations deal with child labor in their codes.

Multinationals' accountability on sustainability: the evolution of third-party assurance of sustainability reports

NARCIS (Netherlands)

Perego, P.; Kolk, A.

2012-01-01

In this article we explore how multinational corporations (MNCs) adopt assurance practices to develop and sustain organizational accountability for sustainability. Using a panel of Fortune Global 250 firms over a period of 10 years, we document the diffusion patterns of third-party assurance of

A critical perspective on the measurement of performance in the empirical multinationality and performance literature

DEFF Research Database (Denmark)

Richter, Nicole Franziska; Schmidt, Robert; Ladwig, Tina J.

2017-01-01

used in empirical studies and the underlying theoretical streams that explain the effects on benefits and costs of multinationality. Our findings indicate that authors still largely rely on overall financial performance measures. Theoretical arguments, in contrast, refer to specific benefit and cost......This paper contributes to the core research in international business (IB), namely the relation between multinationality and performance, and is concerned with the quality of past empirical research designs. On the basis of 49 studies, we critically evaluate the match between performance measures...... positions that are better reflected in operational performance indicators. In our view, the idiosyncratic choice of the performance measures contributes to the varying results in past studies. We offer suggestions for improving future research designs....

Key Success Factors of Innovation in Multinational Agrifood Prospector Companies

OpenAIRE

Fortuin, Frances T.J.M.; Batterink, Maarten H.; Omta, S.W.F. (Onno)

2007-01-01

The Wageningen Innovation Assessment Tool (WIAT) assesses a company’s drivers and barriers to innovation and benchmarks the critical success and failure factors of its innovation projects with data of agrifood prospector companies around the world. The present paper discusses its application in 12 multinational agrifood prospector companies in the Netherlands and France. It is concluded that WIAT by uncovering the tacit knowledge of the innovation project team creates opportunities for subs...

Multinational Channel Strategy and Customer Value in an Emerging Economy

OpenAIRE

Fredrick O. Aila, Hazel Mumbo; Odhiambo Odera; Gerald Ondiek; Jairo K. Mise; Eddy Owaga

2011-01-01

This paper examines the impact of multinational channel strategy on customer value by assessing customer demand side issues. It assess the relationship between order cycle time, stock availability and sales to describe the impact of distribution strategy on customer value. The study was carried in locations comprised of Equator Bottlers Limited franchise territory within five districts in Western Kenya. A cross-section survey using a structured questionnaire was used to collect data. Data wa...

Innovation in the strategies of Internationalization of Brazilian Multinationals: Evaluation of the Cultural National Dimensions: A Study Case of the Meat Processing Sector

Directory of Open Access Journals (Sweden)

Riccardo Rovai

2013-12-01

Full Text Available This article sketches the evolution of Brazilian multinational companies, from the perspective of the development of Latin-American multinational companies, with respect to the process of globalization. With this article, we looked to characterize the typical profile of these enterprises in agreement with the Dunning Model to confirm if this typology is adequate for the characterization of internationalization strategies. We also explored the Theory of the Cultural Dimensions of Hofstede. While doing this, we analyzed which model measures the strategic alignment and is more orientated in terms of: (i exploration of natural resources and advantages of costs of labor not qualified (resource seeking, advantages; (ii location and synergies of market (market seeking, investments; (iii search of strategic assets of the type efficiency seeking (for what they look to rationalize the production and to explore savings of specialization and location, investments; and (iv type of strategic asset seeking (turned to the acquisition of resources and competences with the objective to develop competitiveness through of the innovation and growth of strategic capacities. We also summarize the referential system that makes possible the development of future inquiries for the delineation of the principal strategies, of the public politics of the National States, and also the financial strategies of these enterprises. Keywords: Strategic innovation; Brazilian multinationals; foreign investment; globalization; Latin American multinationals and multinationals from emerging countries

The Role of Culture on Knowledge Transfer: The Case of the Multinational Corporation

Science.gov (United States)

Lucas, Leyland M.

2006-01-01

Purpose: This paper aims to look at the issue of culture's role in knowledge transfer within multinational corporations (MNCs). Studies of MNCs have hinted at the importance of culture to the performance of subsidiaries. Using Hofstede's cultural dimensions of power distance, individualism/collectivism, uncertainty avoidance, and…

International trade. Multinational aspects.

Science.gov (United States)

Ozawa, Y

2000-01-01

Of numerous regional economic agreements, the European Union (EU), the North American Free Trade Agreement (NAFTA), South American Common Market (MERCOSUR), the Association of Southeast Asian Nations (ASEAN), the South Asian Association for Regional Cooperation (SAARC) and the Australia-New Zealand Closer Economic Relations Agreement are examples that are actively pursuing regional integration for freer trade of animals and animal products. The World Trade Organization (WTO) believes that regional and multinational integration initiatives are complements rather than alternatives in the pursuit of more open trade. In the efforts to harmonize SPS standards among multilateral trading nations, it is recommended that national requirements meet the standards developed by the OIE and the FAO/WHO Codex Alimentarius Commission as the minimum requirements rather than adopting the standards of the lowest common denominator. Regional grouping may hinder multilateral or bilateral trade between the countries of a group and those of the other groups. How to eliminate such non-tariff barriers as traditional trade custom remains to be examined. Ongoing activities of VICH (Harmonisation of Technical Requirements for Registration of Veterinary Medical Products) may pave the way for more open trade in pharmaceutical products between multilateral regional groups.

An exploration into the home field, global advantage and liability of unfamiliarness hypotheses in multinational banking

Directory of Open Access Journals (Sweden)

Fadzlan Sufian

2011-09-01

Full Text Available This paper seeks to expand the efficiency paradigm of the eclectic theory in multinational banking within the context of a developing country banking sector. We employ the Data Envelopment Analysis (DEA method to examine the efficiency of multinational banks operating in the Malaysian banking sector from 1995 to 2007. We then employ the panel regression analysis to examine the impact of origins on bank efficiency. We find foreign banks from North America to be the most efficient banking group, providing support to the ‘limited form’ of the global advantage hypothesis. On the other hand, we do not find evidence on both the liability of unfamiliarness and home field advantage hypotheses.

Can harmonized regulation overcome intra-European differences? Insights from a European Phase III stem cell trial.

Science.gov (United States)

Hauskeller, Christine

2017-09-01

Harmonized regulation of research with human stem cells in Europe has shaped innovation in regenerative medicine. Findings from a Phase III academic clinical trial of an autologous cell procedure illustrate the obstacles that a multinational trial faces. A typology of the obstacles encountered, may help other teams embarking upon trials. The findings throw light on the situation of clinician-scientists in clinical innovation, as the expertise to run scientific trials is very complex. The innovation route of clinical translation takes insufficient account of the interdependencies between multiple social and cultural factors from outside the laboratory and the clinic. For ethical reasons, however, academic and business routes to stem cell treatments ought to be enabled by the regulators. Suggestions arise, how academics can prepare for trials, that academic research needs better institutional support and that new models of medical innovation may need to be developed for regenerative medicine.

Double standards: the multinational asbestos industry and asbestos-related disease in South Africa.

Science.gov (United States)

McCulloch, Jock; Tweedale, Geoffrey

2004-01-01

This study documents and contrasts the development of knowledge about asbestos-related disease (ARD) in South Africa and the United Kingdom. It also contributes to the globalization debate by exploring corporate decision-making in a multinational industry. Between the 1930s and 1960s, the leading U.K. asbestos companies developed a sophisticated knowledge of ARD, though in South Africa, where the leading companies such as Turner & Newall and Cape Asbestos owned mines, there was little attempt to apply this knowledge. Asbestos mines (and their environments) in South Africa were uniquely dusty and ARD was rife. Social and political factors in South Africa, especially apartheid, allowed these companies to apply double standards, even after 1960 when the much more serious hazard of mesothelioma was identified. This shows the need for greater regulation of multinationals. Because of the lack of such regulation in the early 1960s, an opportunity was lost to prevent the current high morbidity and mortality of ARD both in South Africa and worldwide.

Doctors’ Perceptions towards Domestic and Multinational Pharmaceutical Products: An Investigation from Developing Country

Directory of Open Access Journals (Sweden)

Jashim Uddin Ahmed

2013-12-01

Full Text Available This exploratory study focuses on doctors’ perception towards domestic and multinational pharmaceutical products. Doctors can heavily influence drug purchase decisions by performing the roles of users (sometimes, influencer, gatekeepers and deciders, while patients perform the role of buyers and users. The difference in perception was measured in terms of products, brand image and pricing. Data were collected from a sample of 15 doctors (n=15 using a questionnaire comprised of 12 questions measured in Likert scales. The study reveals that brand image is the most influential factor for price of medicines and brand image is highly related to quality and the level of promotion for the underlying product. Furthermore, doctors perceive multinational products to be different and better than domestic products due to their stronger brand image. This study highlights that doctors’ preferences are not fully unbiased and can be influenced by pharmaceutical companies. Due to its exploratory nature, findings might need to be validated in a further study with a larger sample.

The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin.

Science.gov (United States)

Vraníková, Barbora; Gajdziok, Jan; Doležel, Petr

2017-03-01

The preparation of liquisolid systems (LSS) represents a promising method for enhancing a dissolution rate and bioavailability of poorly soluble drugs. The release of the drug from LSS tablets is affected by many factors, including the disintegration time. The evaluation of differences among LSS containing varying amounts and types of commercially used superdisintegrants (Kollidon® CL-F, Vivasol® and Explotab®). LSS were prepared by spraying rosuvastatin solution onto Neusilin® US2 and further processing into tablets. Varying amounts of superdisintegrants were used and the differences among LSS were evaluated. The multiple scatter plot method was used to visualize the relationships within the obtained data. All disintegrants do not showed negative effect on the flow properties of powder blends. The type and concentration of superdisintegrant had an impact on the disintegration time and dissolution profiles of tablets. Tablets with Explotab® showed the longest disintegration time and the smallest amount of released drug. Fastest disintegration and dissolution rate were observed in tablets containing Kollidon® CL-F (≥2.5% w/w). Also tablets with Vivasol® (2.5-4.0% w/w) showed fast disintegration and complete drug release. Kollidon® CL-F and Vivasol® in concentration ≥2.5% are suitable superdisintegrants for LSS with enhanced release of drug.

Total hepatocellular disposition profiling of rosuvastatin and pitavastatin in sandwich-cultured human hepatocytes.

Science.gov (United States)

Kanda, Katsuhiro; Takahashi, Ryosuke; Yoshikado, Takashi; Sugiyama, Yuichi

2018-04-09

This study describes the total disposition profiling of rosuvastatin (RSV) and pitavastatin (PTV) using a single systematic procedure called D-PREX (Disposition Profile Exploration) in sandwich-cultured human hepatocytes (SCHH). The biliary excretion fractions of both statins were clearly observed, which were significantly decreased dependent on the concentration of Ko143, an inhibitor for breast cancer resistance protein (BCRP). Ko143 also decreased the basolateral efflux fraction of RSV, whereas that of PTV was not significantly affected. To understand these phenomena, effects of Ko143 on biliary excretion (BCRP and multidrug resistance-associated protein (MRP) 2) and basolateral efflux (MRP3 and MRP4) transporters were examined using transporter-expressing membrane vesicles. BCRP, MRP3 and MRP4-mediated transport of RSV was observed, and Ko143 inhibited these transporters except MRP3. BCRP and MRP4 also mediated the transport of PTV, but the Ko143-mediated inhibition was only clear for BCRP. These results might explain the Ko143-mediated complete and partial inhibition of the biliary excretion and the basolateral efflux of RSV, respectively, in SCHH. In conclusion, D-PREX with sequential sampling of supernatants prior to cell lysis enables the evaluation of total drug disposition profiles resulting from complex interplays of intracellular pathways, which would provide high-throughput evaluation of drug disposition during drug discovery. Copyright © 2018 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.

Multinational Experiment 7. Protecting Access to Space: Presentation to Senior Leaders

Science.gov (United States)

2013-07-08

Multinational Experiment 7: Outcome 3: Space Access Briefing to SLS 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...operations Consequence management Ship status during search & rescue Tele-medicine Broadband internet TV signal distribution Satellite radio Rural...military-usage • Significant economic & societal consequences Access to space at risk • Current approach unsustainable • Broad range of threats

Expanding Simulations as a Means of Tactical Training with Multinational Partners

Science.gov (United States)

2017-06-09

threat.8 “Strengthen our global network of allies and partners” remains a national military objective.9 The eight key components of globally integrated ...validity of the simulations environment.23 What LVC-IA was developed to do was create an Integrated Training Environment (ITE). Through the ITE, a...with multinational partners. Through comparative document analysis, the research focused on understanding the mission of regionally aligned forces

FOCUS THE CONSUMER MARKET A dream or reality for multinational companies

Institute of Scientific and Technical Information of China (English)

MICHAELO＇NEILL

2004-01-01

As the Chinese economy maintains its near double digit growth, opportunities for foreign investors continue to emerge. But away from the staggering statistics, how realistic is the China dream for multinational companies (MNCs)? The messages are mixed. On the one hand are those who continue to hail the Chinese consumer revolution, pointing to market size as reason enough for entering the fray. O'n the other

A Human Resources Perspective on Responsible Corporate Behavior. Case Study: The Multinational Companies in Western Romania

Directory of Open Access Journals (Sweden)

Ciprian Obrad

2018-03-01

Full Text Available This article aims to show the extent to which socially responsible Human Resource Management practices are implemented in multinational companies. As more recent studies highlight, the manner in which companies in Romania presently comprehend the social responsibility of their actions is mostly aimed towards the social component of the outer environment in which they function and less towards their own employees. In Romania, at the moment, there are only a few studies that catalogue the efforts made by companies in order to become more responsible towards their employees, or in other words, studies that present Corporate Social Responsibility (CSR within its relationship with Human Resources Management (HRM. The research method we used for our case study was the semi-structured interview, applied on 32 respondents from the multinational companies carrying out their activities in the automotive sector in western Romania. Our study shows that multinational companies from the automotive sector are aware that CSR effects a series of long-term advantages, either externally—enhancing the company’s reputation and consolidating its brand as employer, its competitive advantage on the market, its media visibility—or internally—fostering an organizational culture that may generate greater engagement from its own employees, and financial advantages.

International Transfer Pricing in Multinational Enterprises

DEFF Research Database (Denmark)

Rossing, Christian Plesner; Cools, Martine; Rohde, Carsten

2017-01-01

Current curricula in management accounting stress the role of transfer pricing as a tool for measuring the performance of responsibility centers and their managers. Recently, however, multinational enterprises (MNEs) have felt increasing pressure to comply with transfer pricing tax regulation...... of responsibility accounting. Specifically, the case study is a fictional MNE, allowing you to apply the OECD Guidelines in practice to cross-border transfers within an MNE, and to discuss the implications of tax-based transfer pricing for responsibility accounting. As a basis for working on the case study....... As a result, tax risk management considerations play a key role in the transfer pricing decisions of MNEs today. This case seeks to provide you with examples of the core principles of international transfer pricing, as well as to allow you to discuss international transfer pricing in the context...

Multinational design evaluation programme - 2009 annual report

International Nuclear Information System (INIS)

2010-06-01

The Multinational Design Evaluation Programme (MDEP) was established in 2006 as a multinational initiative to develop innovative approaches to leverage the resources and knowledge of the national regulatory authorities who are currently or will be tasked with the review of new reactor power plant designs. MDEP comprises 13 countries' nuclear regulatory authorities and is structured under 3 design-specific working groups and 3 issue-specific working groups which meet several times a year. The OECD/NEA facilitates MDEP's activities by acting as technical secretariat for the programme. The MDEP Policy Group (PG) and the Steering Technical Committee (STC) oversee the programme. MDEP's main objectives can be defined as follows: - to enhance multilateral co-operation within existing regulatory frameworks; - to encourage multinational convergence of codes, standards and safety goals; - to implement the MDEP products in order to facilitate the licensing of new reactors, including those being developed by the Generation IV International Forum. To carry out the work, two main lines of activity have been implemented: - the exploration of opportunities for harmonisation of regulatory practices; - the cooperation on the safety reviews of specific reactor designs. MDEP engages with key stakeholders involved in ensuring the safety of new reactor designs, manufacturing, construction and operation. At this time, these stakeholders include other national regulatory authorities and international organisations involved in ensuring nuclear safety including the IAEA, Western European Nuclear Regulators' Association (WENRA), NEA Committees on Nuclear Regulatory Activities (CNRA) and Safety of Nuclear Installations (CSNI), the various reactor vendors, nuclear component manufacturers, mechanical and electrical standards development organisations, reactor operators and licensees and key industry representatives such as World Nuclear Association (WNA). To this end, the MDEP has organised a

BANKING ON MULTINATIONALS: THE DETERMINANTS OF CROSS-BORDER CREDITS TO CENTRAL AND EASTERN EUROPE, 1990-2015

Directory of Open Access Journals (Sweden)

Roksolana Zapotichna

2017-11-01

Full Text Available Taking into account the rising dependence of Central and Eastern Europe on multinational banks’ credits, the main purpose of the article is to identify and examine the determinants of cross-border credits through a methodology based on “push” and “pull” factors. The author presents the results of a regression analysis on the determinants of cross-border credits provided by multinational banks from EU-15 to Central and Eastern Europe over the period of 1990-2015 by using the statistical data compiled and published by the Bank for International Settlements. The obtained results suggest that global as well as home and host country level determinants influence cross-border credits but to a different extent. According to our results, higher stability and predictability of global economic environment contribute to higher cross-border credit growth. The results of the host country determinants analysis indicate that more effective and profitable economies receive more credits from multinational banks. We also find that multinational banks provide more credits to countries with small markets, low inflation rate, high external debt burden, high capital account deficit, fixed exchange rate regime, and developed institutional environment. Regarding home level determinants, we find the existence of a negative correlation between home country economic cycle and the amount of cross-border credits received by the host country, which can be explained by low economic growth in continental Europe over the period under consideration that stimulated European banks to expand lending on foreign markets with higher profit opportunities. Thus, cross-border credits appear to have been countercyclical to growth in home countries and procyclical to growth in host countries. Finally, it is found that host country level determinants play the most important role in explaining changes in cross-border credits on host countries in Central and Eastern Europe during

The Regional Sales of Multinationals in the World Cosmetics Industry

OpenAIRE

Chang Hoon Oh; Alan M. Rugman

2006-01-01

This paper analyzes the regional characteristics and strategies of multinational enterprises (MNEs) in the world cosmetics and toiletries industry, based on the new work by Rugman on regional strategy. We test the proposition that MNEs may asymmetrically develop their upstream and downstream firm specific advantages (FSAs). We find that the upstream activities of the MNEs in cosmetics are home region based but that downstream activities are less so. Further, the asymmetry of FSAs in the world...

Do multinational retailers affect the export competitiveness of host countries?

OpenAIRE

Cheptea, Angela

2014-01-01

The paper investigates how the overseas activity of multinational retailers (MRs) affects the global export patters of host country firms. Recent empirical work testifies that the entry of foreign retailers leads to a productivity upgrade in the domestic upstream sectors. Combined with the main result of the new new international trade theory on firm heterogeneity, an increase in the export capacity of local firms should also follow. The current paper establishes a connection between these em...

Ethical issues in a stage 1 cognitive-behavioral therapy feasibility study and trial to reduce alcohol use among HIV-infected outpatients in western Kenya.

Science.gov (United States)

Papas, Rebecca K; Gakinya, Benson N; Baliddawa, Joyce B; Martino, Steve; Bryant, Kendall J; Meslin, Eric M; Sidle, John E

2012-07-01

Epidemics of both HIV/AIDS and alcohol abuse in sub-Saharan Africa have spurred the conduct of local behavioral therapy trials for these problems, but the ethical issues involved in these trials have not been fully examined. In this paper, we discuss ethical issues that emerged during the conduct of a behavioral intervention adaptation and trial using cognitive-behavioral therapy to reduce alcohol use among HIV-infected outpatients in Eldoret, Kenya. The study was performed within our multinational collaboration, the USAID-Academic Model Providing Access to Healthcare Partnership. We discuss relevant ethical considerations and how we addressed them.

Preparation of the National Programme for the Spent Fuel and Radioactive Waste Management Taking Into Account Possibility of Potential Multinational/Regional Disposal Facilities Development

International Nuclear Information System (INIS)

Kegel, L.

2016-01-01

Conclusions: • Final disposal in deep geological repository (national, regional or multinational) is planed: → Implementation of disposal after NPP closure (>2065). • The strategy principle of international cooperation: → National responsibility for radioactive waste and spent fuel management is considered in parallel with active participation in international regional efforts to make progress in connection to joint regional programmes on disposal. • Implementation is challenging but technical feasible. • Timely and appropriate “nesting” of multinational solutions into national plans. • Although a multinational repository is likely not ripe for development today, actions taken now can be important to increase the likelihood of its future development

Global Cities and Multinational Enterprise Location Strategy

DEFF Research Database (Denmark)

Goerzen, Anthony; Geisler Asmussen, Christian; Nielsen, Bo Bernhard

2013-01-01

We combine the concept of location derived by economic geographers with theories of the multinational enterprise (MNE) and the liability of foreignness developed by international business scholars, to examine the factors that propel MNEs toward, or away from, “global cities”. We argue that three...... distinctive characteristics of global cities – global interconnectedness, cosmopolitanism, and abundance of advanced producer services – help MNEs overcome the costs of doing business abroad, and we identify the contingencies under which these characteristics combine with firm attributes to exert......- and subsidiary-level factors, including investment motives, proprietary capabilities, and business strategy. Our study provides important insights for international business scholars by shedding new light on MNE location choices and also contributes to our understanding of economic geography by examining...

Does the meta-environment determine firm performance? Theory and evidence from European multinational enterprises

NARCIS (Netherlands)

de Jong, Gjalt; Phan, T. Binh; van Ees, Hans; Phan, T.T.

We study an underrepresented area in the international business literature: the effect of the meta-environment on multinational enterprise (MNE) performance. A meta-environment is a symbiosis of all country environments where an MNE operates. This conceptualization of a firm's external context is

Taxation of Multinational Enterprises in a Global Market: Moving to Corporate Tax 2.0?

NARCIS (Netherlands)

M.F. de Wilde (Maarten)

2016-01-01

textabstractHow countries tax the profits of multinational enterprises has become hopelessly outdated. The recent OECD/G20 Base Erosion and Profit Shifting Project has left the existing international corporate taxation framework essentially intact. Perhaps it is time to consider a truly fundamental

Aggressive International Tax Planning by Multinational Corporations: The Canadian Context and Possible Responses

Directory of Open Access Journals (Sweden)

Brian J. Arnold

2014-09-01

Full Text Available Aggressive international tax planning by multinational corporations has lately fallen under intense political scrutiny. U.S. politicians have called out some American multinationals, including Apple, Amazon, Starbucks and Google, for relocating profits abroad to avoid American taxes. More recently, politicians accused Burger King of being unpatriotic for its own purported “tax inversion” maneuver, in which it would acquire Canada’s Tim Hortons and shift the head office from Florida to Ontario, benefitting from the lower northern tax rates. The Chicago-based Walgreens pharmacy chain recently backed off a “tax inversion” plan to relocate to Switzerland (the former headquarters of Alliance Boots, a company acquired by Walgreens, apparently having assessed the political risk as too high. This sort of aggressive international tax planning by multinational corporations was what G20 members had committed to fighting against when they endorsed the OECD’s “action plan” against base erosion and profit shifting (BEPS. Canada has been vigilant about improving its tax framework to prevent non-resident corporations from eroding the Canadian tax base, having enacted thin-capitalization rules and, more recently, foreign-affiliate-dumping rules, as well as proposing anti-treaty-shopping measures. But despite Canada’s commitment to the OECD’s BEPS Action Plan, the Canadian government has been reluctant to follow through on implementing rules that might affect its own resident corporations and their international competitiveness. This is most notably visible in the generous participation exemption for dividends from foreign affiliates, the absence of rules restricting the deductibility of interest expenses incurred to earn exempt dividends from foreign affiliates. Canada may be reluctant to fully follow through on all aspects of the OECD’s BEPS Action Plan. As the examples of Apple, Amazon, Google and Starbucks demonstrate, the American

How weak are the signals? International price indices and multinational enterprises

OpenAIRE

Lorraine Eden; Peter Rodriguez

2004-01-01

International price indices (IPIs) provide the most timely and comprehensive market information available to international business. How do multinational enterprises (MNEs) affect the validity of IPIs? We review the earlier debate over methods for calculating IPIs, which concluded that unit values were inferior to specification prices, although most governments produce only unit value indexes. We explore three ways in which MNEs can affect the validity of IPIs: determining the ‘representative...

Cultural Sources of Variance in Telework Adoption in two Subsidiaries of an ICT-Multinational

NARCIS (Netherlands)

Peters, P.; Bleijenbergh, I.L.; Oldenkamp, E.

2009-01-01

This comparative case-study examines to what extent telework adoption among line managers in two subsidiaries of the same ICT-multinational in France and the Netherlands mirrors cultural values. In the Dutch case, a formal telework program was discontinued, but managers viewed informal teleworking

The Search for Synergy between Institutions and Multinationals: Institutional Uncertainty and Patterns of Internationalization

NARCIS (Netherlands)

A.R. Muller (Allan); R.J.M. van Tulder (Rob)

2005-01-01

textabstractThe debate on globalization has long been characterized by theses of institutional convergence and divergence. The emergence of Anglo-Saxon shareholder capitalism as the dominant paradigm since the start of the 1990s is associated with the pursuit of global strategies by Multinational

MultiNational Corporations work environment of brewing firms and employees productivity

Directory of Open Access Journals (Sweden)

Olugbenga Abiola OJO

2015-12-01

Full Text Available This study examined the multinational work environment and employee productivity by examining if the elements conducive work environment assists MNCs (multinational corporations employee to be motivated at work and if the provision of infrastructural facilities have a significant relationship on employee satisfaction that affect employee productivity. The data required for this study was gotten through the instrument of questionnaire. One hundred and twenty four (124 copies of questionnaire were administered out of which one hundred and thirteen (113 were retrieved for analysis. Three hypotheses were formulated from the structured research questions. Regression and correlational analysis were used to test the hypotheses through the statistical package for Social Sciences (SPSS 18.0. The result showed that conducive work environment assists MNCs employee to be motivated at work (R2 = 0.546, at P < 0.05 and that provision of infrastructural facilities have a significant relationship on employee satisfaction (0.699, at P < 0.05. The study therefore recommends among others that that organization should see conducive environment and infrastructural development as a way of helping them to continue being in businesses rather than seeing it as a means of luxury to achieve their desires because it has been proven that infrastructural facility development has assisted in enhancing employee satisfaction.

Multinational underground nuclear parks

Energy Technology Data Exchange (ETDEWEB)

Myers, C.W. [Nuclear Engineering and Nonproliferation Division, Los Alamos National Laboratory, MS F650, Los Alamos, NM 87544 (United States); Giraud, K.M. [Wolf Creek Nuclear Operating Corporation, 1550 Oxen Lane NE, P.O. Box 411, Burlington, KS 66839-0411 (United States)

2013-07-01

Newcomer countries expected to develop new nuclear power programs by 2030 are being encouraged by the International Atomic Energy Agency to explore the use of shared facilities for spent fuel storage and geologic disposal. Multinational underground nuclear parks (M-UNPs) are an option for sharing such facilities. Newcomer countries with suitable bedrock conditions could volunteer to host M-UNPs. M-UNPs would include back-end fuel cycle facilities, in open or closed fuel cycle configurations, with sufficient capacity to enable M-UNP host countries to provide for-fee waste management services to partner countries, and to manage waste from the M-UNP power reactors. M-UNP potential advantages include: the option for decades of spent fuel storage; fuel-cycle policy flexibility; increased proliferation resistance; high margin of physical security against attack; and high margin of containment capability in the event of beyond-design-basis accidents, thereby reducing the risk of Fukushima-like radiological contamination of surface lands. A hypothetical M-UNP in crystalline rock with facilities for small modular reactors, spent fuel storage, reprocessing, and geologic disposal is described using a room-and-pillar reference-design cavern. Underground construction cost is judged tractable through use of modern excavation technology and careful site selection. (authors)

Key Success Factors of Innovation in Multinational Agri-food Prospector Companies

OpenAIRE

Fortuin, F.T.J.M.; Batterink, M.H.; Omta, S.W.F.

2007-01-01

The Wageningen Innovation Assessment Tool (WIAT) compares the self assessment of the drivers and barriers to innovation at the company level and the critical success and failure factors of innovation at the project level with data of agrifood prospector firms around the world. In total 46 innovation projects, 11 successfully concluded and 6 failed projects, as well as 29 running projects in 12 multinational agrifood prospector companies in the Netherlands and France, two innovation consortia ...

Multinational Enterprises and New Trade Theory: Evidence for the Convergence Hypothesis

OpenAIRE

Barrios, Salvador; Görg, Holger; Strobl, Eric

2001-01-01

According to the ‘convergence hypothesis’ multinational companies will tend to displace national firms and trade as total market size increases and as countries converge in relative size, factor endowments, and production costs. Using a recent model developed by Markusen and Venables (1998) as a theoretical framework, we explicitly develop empirical measures to proxy bilateral FDI between two countries and address their properties with regard to the convergence hypothesis. Using a panel of da...

Conducting multinational, cross-cultural research in the functional gastrointestinal disorders: issues and recommendations. A Rome Foundation working team report.

Science.gov (United States)

Sperber, A D; Gwee, K A; Hungin, A P; Corazziari, E; Fukudo, S; Gerson, C; Ghoshal, U C; Kang, J-Y; Levy, R L; Schmulson, M; Dumitrascu, D; Gerson, M-J; Chen, M; Myung, S-J; Quigley, E M M; Whorwell, P J; Zarzar, K; Whitehead, W E

2014-11-01

Cross-cultural, multinational research can advance the field of functional gastrointestinal disorders (FGIDs). Cross-cultural comparative research can make a significant contribution in areas such as epidemiology, genetics, psychosocial modulators, symptom reporting and interpretation, extra-intestinal co-morbidity, diagnosis and treatment, determinants of disease severity, health care utilisation, and health-related quality of life, all issues that can be affected by geographical region, culture, ethnicity and race. To identify methodological challenges for cross-cultural, multinational research, and suggest possible solutions. This report, which summarises the full report of a working team established by the Rome Foundation that is available on the Internet, reflects an effort by an international committee of FGID clinicians and researchers. It is based on comprehensive literature reviews and expert opinion. Cross-cultural, multinational research is important and feasible, but has barriers to successful implementation. This report contains recommendations for future research relating to study design, subject recruitment, availability of appropriate study instruments, translation and validation of study instruments, documenting confounders, statistical analyses and reporting of results. Advances in study design and methodology, as well as cross-cultural research competence, have not matched technological advancements. The development of multinational research networks and cross-cultural research collaboration is still in its early stages. This report is intended to be aspirational rather than prescriptive, so we present recommendations, not guidelines. We aim to raise awareness of these issues and to pose higher standards, but not to discourage investigators from doing what is feasible in any particular setting. © 2014 John Wiley & Sons Ltd.

Knowledge Transfer in Product Development: an Analysis of Brazilian Subsidiaries of Multinational Corporations

Directory of Open Access Journals (Sweden)

Dusan Schreiber

2011-07-01

Full Text Available Several studies about knowledge transfer in multinational corporations have found that the process is influenced by factors such as absorptive capacity, tacit knowledge and power relations, all of which impact knowledge sharing strategies between corporate headquarters and foreign subsidiaries. A multiple case study of Brazilian subsidiaries of three multinational corporations using in-depth interviews, based on a conceptual model consisting of four propositions, was conducted to identify factors linked to the knowledge transfer process and to assess their influence on that transfer. The first proposition tries to assess explicit knowledge, primarily through the use of IT tools; the second analyzes the role of the subsidiary within the corporate network and how it influences the degree of knowledge sharing. The third assesses the influence of subsidiary absorptive capacity and the fourth analyzes the impact of worker exchange programs on knowledge sharing between headquarters and foreign subsidiaries. Study results confirm the four propositions and enable the identification of relationships between factors, especially explicit knowledge and worker expatriation as complementary factors in knowledge transfer strategies.

Productivity Effects of United States Multinational Enterprises : The Roles of Market Orientation and Regional Integration

NARCIS (Netherlands)

Smeets, Roger; Wei, Yingqi

2010-01-01

Smeets R. and Wei Y. Productivity effects of United States multinational enterprises: the roles of market orientation and regional integration, Regional Studies. This paper considers the role of market orientation and regional integration in foreign direct investment (FDI) productivity effects.

Three Lenses on the Multinational Enterprise: Politics, Corruption and Corporate Social Responsibility.

OpenAIRE

Peter Rodriguez; Donald S. Siegel; Amy Hillman; Lorraine Eden

2006-01-01

Scholars who analyze multinational enterprises (MNEs) recognize the complex relationship between international business (IB) and society. However, compared with other IB topics, research on politics, corruption and corporate social responsibility – ‘three lenses’ on the MNE – remains somewhat embryonic, with unresolved issues regarding frameworks, measurement, methods, and theory. This presents unique opportunities for integration and extension of disciplinary perspectives, which we explore i...

Measuring the Value of Succession Planning and Management: A Qualitative Study of Multinational Companies

Science.gov (United States)

Kim, Yeonsoo

2010-01-01

This article proposes a model for planning and operating an effective succession planning and management (SP&M) program and measuring its value. The nature of the research is exploratory, following a qualitative approach using in-depth interviews. Representatives of multinational companies interviewed for this study revealed that succession…

Analysing employment practices in Western European multinationals: coordination, industrial relations and employment flexibility in Poland

NARCIS (Netherlands)

Kahancová, M.; van der Meer, M.

2005-01-01

Despite the fact that multinational companies (MNCs) in Central Eastern Europe significantly contribute to employment growth in the region, qualitative knowledge about diffusion of employment practices in this region, and about coordination of MNCs with local labour market actors and institutions is

Money or Ethics : Multinational corporations and religious organisations operating in an era of corporate responsibility

NARCIS (Netherlands)

K.C. van Cranenburgh (Katinka)

2016-01-01

markdownabstractIt is a general assumption that Religious Organisations (ROs) are driven by religious beliefs and values, whilst multinational corporations (MNCs) are considered to be concerned about their profits, their share price and their reputation. When ROs invest in capital markets, they

Human Resource Development Practices, Managers and Multinational Enterprises in Australia: Thinking Globally, Acting Locally

Science.gov (United States)

Sablok, Gitika; Stanton, Pauline; Bartram, Timothy; Burgess, John; Boyle, Brendan

2017-01-01

Purpose: The purpose of this paper is to examine the HRD practices of multinational enterprises (MNEs) operating in Australia to understand the value that MNEs place on investment in their human capital, particularly managerial talent. Design/methodology/approach: Drawing on a representative sample of 211 MNEs operating in Australia, this paper…

Multinational design evaluation programme - Annual report March 2013-March 2014

International Nuclear Information System (INIS)

2014-04-01

The Multinational Design Evaluation Programme (MDEP) is a multinational initiative to leverage the resources and knowledge of national regulatory authorities who are, or will shortly be, undertaking the review of new reactor power plant designs. MDEP incorporates a broad range of activities including enhancing multilateral cooperation within existing regulatory frameworks, and increasing multinational convergence of codes, standards, guides, and safety goals. A key concept throughout the work of MDEP is that national regulators retain sovereign authority for all licensing and regulatory decisions. Working groups are implementing the activities in accordance with programme plans with specific activities and goals, and have established the necessary interfaces both within and outside of the MDEP members. In the past year, MDEP has expanded to include cooperation on the VVER and ABWR designs and additional members have begun participating in the programme to share their experiences on these design reviews. This report provides the current status of the programme. Significant progress is being made on the overall MDEP goals of increased cooperation and enhanced convergence of requirements and practices. In addition, the lessons learnt from the 11 March 2011, events at the Fukushima Daiichi nuclear power plant are being incorporated into MDEP activities through the programme plans of design-specific working groups (DSWG). On this topic, the EPR Working Group has issued a common position which will be supplemented by five technical appendices by the end of 2014. Other DSWG are in the process of drafting such common positions. Several DSWGs' are facilitating the MDEP programme goal of enhanced cooperation: the EPRWG, the Vendor Inspection Cooperation Working Group (VICWG), the Digital Instrumentation and Controls Working Group (DICWG), the Codes and Standards Working Group (CSWG). Accomplishments to date provide confidence that the MDEP membership, structure and processes

Identifying motivational factors within a multinational company

Directory of Open Access Journals (Sweden)

Daniela Bradutanu

2011-08-01

Full Text Available The aim of the study is to identify the main motivational factors within a multinational company. The first objective is to identify work functions, formulated on Abraham Maslow’s pyramid, following the identification of the key characteristics that motivate an employee at the work place and last, but not least, the type of motivation that employees focus, intrinsic or extrinsic. The research method targeted a questionnaire based survey, including various company employees and an interview with the manager. The results confirmed that in Romania, employees put great emphasis on extrinsic motivation, a certain income and job security being primary. These results have implications for managers that in order to effectively motivate staff, first, must know their needs and expectations. To identify the main needs and motivational factors we had as a starting point Maslow's pyramid.

Rationale, Design, and Baseline Data of the Insulin Glargine (Lantus) Versus Insulin Detemir (Levemir) Treat-To-Target (L2T3) Study: A Multinational, Randomized Noninferiority Trial of Basal Insulin Initiation in Type 2 Diabetes

NARCIS (Netherlands)

Swinnen, Sanne G. H. A.; Snoek, Frank J.; Dain, Marie-Paule; DeVries, J. Hans; Hoekstra, Joost B. L.; Holleman, Frits

2009-01-01

Objective: To discuss the design and baseline data of the Lantus (R) (sanofi-aventis, Paris, France) versus Levemir (R) (Novo Nordisk A/S, Bagsvaerd, Denmark) Treat-To-Target (L2T3) study, a multinational, randomized comparison between the basal insulin analogs insulin glargine and insulin detemir.

Multinational evidence-based recommendations for the diagnosis and management of gout

DEFF Research Database (Denmark)

Sivera, Francisca; Andrés, Mariano; Carmona, Loreto

2014-01-01

with a systematic literature review. Medline, Embase, Cochrane CENTRAL and abstracts from 2010-2011 European League Against Rheumatism and American College of Rheumatology meetings were searched in each review. Relevant studies were independently reviewed by two individuals for data extraction and synthesis...... and risk of bias assessment. Using this evidence, rheumatologists from 14 countries (Europe, South America and Australasia) developed national recommendations. After rounds of discussion and voting, multinational recommendations were formulated. Each recommendation was graded according to the level...

Political Ideology and the Discursive Construction of the Multinational Hotel Industry

DEFF Research Database (Denmark)

Maclean, Mairi; Harvey, Charles; Suddaby, Roy

2018-01-01

How might political ideology help to shape an organizational field? We explore the discursive construction of the multinational hotel industry through analysis of one of its leading actors, Hilton International (HI), conceived by Conrad Hilton as a means of combatting communism by facilitating...... world peace through international trade and travel. While the politicized rhetoric employed at hotel openings reflected institutional diversity, it resonated in parallel with a strong anti-communist discourse. We show that through astute political sensemaking and sensegiving, macro-political discourse...

Trade, Foreign Direct Investment or Acquisition: Optimal Entry Modes for Multinationals

OpenAIRE

Theo Eicher; Jong Woo Kang

2004-01-01

We examine multinationals’ optimal entry modes into foreign markets as a function of market size, FDI fixed costs, tariffs and transport costs. Our results highlight why large countries are more likely to attract acquisition investment, while intermediate-sized countries may be served predominantly through trade, even in the presence of high tariffs. Small countries are most likely to experience either FDI or no entry. We also show how these results vary with the competition intensity in th...

Multinational web uses and gratifications: Measuring the Social Impact of Online Participation Across National Boundaries

NARCIS (Netherlands)

A.C.M. Dekkers; B. Sundararajan; L. Peters; P. Grace-Farfaglia; S.H. Park

2014-01-01

This paper will describe the rationale and findings from a multinational study of online uses and gratifications conducted in the United States, Korea, and the Netherlands in spring 2003. A survey research method of study was conducted using a questionnaire developed in three languages and was

Closing the gap between spent fuel storage and final disposal in a multinational management system

International Nuclear Information System (INIS)

Bredell, P.J.

1999-01-01

In this paper, a multinational spent fuel management concept is proposed. The management concept is based on a service agreement between countries, which intend participating in a common spent fuel (SNF) management venture. Accordingly, one of the participants in this venture would act as the hosting country, while the others fulfil the role of customer countries. The hosting country would agree to accept SNF from customer countries under specific conditions, as required by the service agreement. The service agreement should cover a sufficient number of options that customers can use, such as storage, reprocessing or disposal. The service offering should be flexible enough to accommodate diverse customer requirements. Typically, the first step in the multinational management process is the storage of the SNF delivered to the hosting country. The final step being the disposal of the material in a deep geologic repository. This paper explores the ways and means of closing the gap between the first and last steps in the management process. (author)

Taxation of Multinational Enterprises in a Global Market: Moving to Corporate Tax 2.0?

OpenAIRE

Wilde, Maarten

2016-01-01

textabstractHow countries tax the profits of multinational enterprises has become hopelessly outdated. The recent OECD/G20 Base Erosion and Profit Shifting Project has left the existing international corporate taxation framework essentially intact. Perhaps it is time to consider a truly fundamental reform of corporate tax systems, i.e. Corporate Tax 2.0.

Knowledge transfer process of Brazilian multinationals: comparing acquired subsidiaries to the greenfield ones

Directory of Open Access Journals (Sweden)

Natacha Bertoia Silva

2012-07-01

Full Text Available The main purpose of this study was to explore the knowledge transfer process between the subsidiaries and the headquarter of Brazilian multinationals, and to identify the most used mechanisms for transferring knowledge. This paper also aims to point out existing barriers in this process, comparing acquired subsidiaries to the greenfield ones. International studies have shown differences in the process of knowledge transfer due to the origin of foreign units (entry mode. We surveyed in 2006 and 2007 a sample of 66 Brazilian subsidiaries of multinationals with overseas activities. As a result, the knowledge transfer from the headquarter to the subsidiary has occurred through meetings with top executives and the reception of Brazilian executives in both types of units. The barriers to knowledge transfer are bland, being clearer in acquired subsidiaries. Cultural resistance is the most prominent. When we focus on the acquired units, the hierarchical structure is seen as a barrier, probably reflecting the centralized attitude by the headquarters. At the same time, the lack of incentives for sharing knowledge is more evident in greenfield units. Also, the syndrome of not invented here is a perceived barrier by acquired units.

Normative and systems integration in human resource management in Japanese multinational companies

OpenAIRE

Furusawa, Masayuki; Brewster, Chris; Takashina, Toshinori

2016-01-01

Purpose\\ud This paper aims to conceptualise a framework of “transnational human resource management” (HRM) and to demonstrate the validity of the model.\\ud \\ud Design/methodology/approach\\ud Evidence is drawn from survey of 93 large Japanese multinational companies (MNCs). Data are analysed through descriptive statistics, hierarchical multiple regression analyses and mediation effect analyses.\\ud \\ud Findings\\ud The analysis reveals that the practices for normative and systems integration are...

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study

Directory of Open Access Journals (Sweden)

Moreno-Manzanaro Miriam

2011-04-01

Full Text Available Abstract Background Studies in bipolar disorder (BD to date are limited in their ability to provide a whole-disease perspective - their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd (NCT01062607 aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. Methods WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales, adherence to treatment (DAI-10 scale and Medication Possession Ratio, quality of life (EQ-5D scale, healthcare resources, and caregiver burden (BAS scale

Taxing the Multinational Enterprise : On the Forced Redesign of Global Value Chains and Other Inefficiencies

NARCIS (Netherlands)

Foss, Nicolai J.; Mudambi, Ram; Murtinu, Samuele

2018-01-01

The taxation of the multinational enterprise (MNE) has been a continuing concern for policy-makers. We argue that the changing nature of the mobile MNE (e.g., its improved ability to fine-slice the value chain and disperse it geographically) makes it increasingly important to rethink current tax

MDEP Common Position CP-VICWG-01. Common Position: Establishment of Common QA/QM Criteria for the Multinational Vendor Inspection CP-VICWG-01

International Nuclear Information System (INIS)

2015-01-01

This document provides a set of common positions for harmonizing inspection criteria called 'Common QA/QM Criteria' which will be used in Multinational Vendor Inspections. This document was prepared by the Vendor Inspection Co-operation Working Group (VICWG) of the Multinational Design Evaluation Program (MDEP). The 'Common QA/QM Criteria' provides the basic areas for consideration when performing Vendor Inspections. The criteria have been developed in conformity with International Codes and Standards such as IAEA, ISO, etc. that MDEP member countries have adopted

Examples of socially responsible practices of multinational enterprises from developed and developing countries in Colombia

Directory of Open Access Journals (Sweden)

Yenni Viviana Duque Orozco

2012-12-01

Full Text Available International business research has considered the Corporate Social Responsibility (CSR of the Multinational Enterprises (MNEs and so Multilateral Organizations have developed different recommendations about what these companies should do in different social areas, especially in labor practices. MNEs play a significant role given their influence and activities in both home and host countries. They play a double role: actor of the problem, but also the actor of the solution. The purpose of the paper is to identify the differences of Socially Responsible Practices (SRP between MNEs from developed countries and MNEs from developing countries in Colombia. The method used in this document is a literature review from several academic databases; and we check CSR programs published in Web sites in the host country (Colombia of six MNE´s The results suggest that Multinationals from developing countries focus their practices on the com­munity, mainly in education programs, while Multinationals from developed countries try to work with all stakeholders and involve particularly aspects related with their business in the programs they develop. This is possible because MNEs from developed countries use better divulgation me­chanisms. SRP less mentioned in both cases are related to employees. Commitment with ethical responsibilities, promote greater economic and social inclusion should be the goals for MNEs in developing countries. In the other hand, the government has to play a more important role in this ground establishing minimum standards for MNEs that want to operate in developing countries, and some education programs to sensitize society into a more responsible consumption, in order to generate social pressure.

Language policies and communication in multinational companies : Alignment with strategic orientation and human resource management practices

NARCIS (Netherlands)

van den Born, Floor; Peltokorpi, Vesa

2010-01-01

This article focuses on the degree of alignment among multinational company (MNC) strategic orientation, human resource management (HRM) practices, and language policies. On the one hand, the authors propose that the coherent, tight alignment among the HRM practices, language policies, and MNC

Will Knjaz Miloš Belong to Foreigners? The Privatization and Image of Multinational Companies in the Serbian Media (2000-2005

Directory of Open Access Journals (Sweden)

Vladimir Miokov

2016-02-01

Full Text Available This study analyses the media coverage of the privatization of Knjaz Miloš, Serbia’s most famous mineral water factory, as well as the manner in which the multinational companies were presented in this process. The focus of the paper is on the conflict between major stakeholders as they were presented in analyzed media texts. Three phases of the privatization process are analysed in this paper. The first phase is the period from October 2000 to September 2003, when the news about privatization came out in the media; the second phase is from August 2003 to December 2003, when the first potential buyers appeared; and third is the period from August 2004 to September 2005, when Knjaz Miloš was finally privatized. The conclusion of this analysis is that a negative image of multinational companies prevails in the domestic media. Such an image is not ideologically coloured (as it was in the 1990s and is seldom openly presented. The general attitude is sceptical, even though an awareness of the importance of the participation of multinational companies in the process of privatization is present.

Multinational corporations, the politics of the world economy, and their effects on women's health in the developing world: a review.

Science.gov (United States)

Hippert, Christine

2002-12-01

Presently, globalization and the world economy maintain power relations that hamper the economic integrity and the political autonomy of the developing world. My paper addresses specific economic conditions that perpetuate poverty and poor health. I examine multinational corporations and their effects on women's health, particularly in Mexico and parts of Asia. The advent of multinational corporate business in Mexico, Malaysia, Philippines, India, and Indonesia has led to increased poverty and human rights abuses. Women bear the brunt of this because of specific international economic arrangements and their low social status, both locally and globally. As a result, their physical, mental, and emotional health is suffering. Solutions to these health problems have been proposed on multiple levels: international top-down approaches (i.e., employing international protectionist regulatory standards, exposing multinationals who infringe on their workers' human rights), as well as local grassroots organizational campaigns (i.e., conducting informational human rights workshops for factory workers). Ultimately, the answers lie in holding corporations accountable to their laborers while developing countries maintain their comparative advantage; this is the only way women's health will improve and the developing world can entice corporate investment.

Multinational enterprises, foreign direct investment and trade in China : A cointegration and Granger-causality approach

NARCIS (Netherlands)

Zhang, Jianhong; Jacobs, Jan; Witteloostuijn, Arjen van

2004-01-01

Multinational enterprises (MNEs) play a dominant role in the international business (IB) literature. Traditionally, by far the majority of IB studies deal with issues at the micro level of the individual MNE, or at the meso level of a sample of individual MNEs. This paper focuses on a macro-level

Continuous Linguistic Rhetorical Education as a Means of Optimizing Language Policy in Russian Multinational Regions

Science.gov (United States)

Vorozhbitova, Alexandra A.; Konovalova, Galina M.; Ogneva, Tatiana N.; Chekulaeva, Natalia Y.

2017-01-01

Drawing on the function of Russian as a state language the paper proposes a concept of continuous linguistic rhetorical (LR) education perceived as a means of optimizing language policy in Russian multinational regions. LR education as an innovative pedagogical system shapes a learner's readiness for self-projection as a strong linguistic…

The representation of expatriates in the corporate governance of subsidiaries of multinational companies: A study from the Czech Republic

Directory of Open Access Journals (Sweden)

Lenka Komarkova

2015-01-01

Full Text Available The issue of the representation of expatriates in the corporate governance of subsidiaries of multinational companies is currently a much debated and yet relatively under-researched topic within the academic community. In connection with the transformation of the economy which has taken place and the activity of multinational companies in CEE countries, there have been discussions about the effect of expatriates on the output and efficiency of the corporate governance of subsidiaries. The main aim of the research carried out was to describe and analyze the representation of expatriates in the exercise of corporate governance in subsidiaries of multinational companies operating in the Czech Republic (CR. The objective of the research was to survey the representation of expatriates in MNC subsidiaries with respect to various characteristics of the subsidiary such as the country where its head office is located (country of headquarters, the size of the subsidiary and the legal form. Using statistical analysis of dependencies, a different representation of expatriates in relation to the legal form of the MNC subsidiary was demonstrated. The size of the subsidiary, measured by the number of employees, also plays a role here. The presence of an expatriate was not demonstrated to have an effect on the financial performance of an MNC subsidiary.

Targets, drivers and metrics in software process improvement: results of a survey in a multinational organization

NARCIS (Netherlands)

Trienekens, J.J.M.; Kusters, R.J.; Genuchten, van M.J.I.M.; Aerts, H.

2007-01-01

This paper reports on a survey amongst software groups in a multinational organization. The survey was initiated by the Software Process Improvement (SPI) Steering Committee of Philips, a committee that monitors the status and quality of software process improvement in the global organization. The

Organizational Values and Knowledge Sharing in Multinational Corporations

DEFF Research Database (Denmark)

Michailova, Snejina; Minbaeva, Dana

2012-01-01

While the existing knowledge sharing literature, in general, emphasizes the link between organizational culture and knowledge sharing, it remains rather ambiguous about how certain components of the former may shape the latter. This issue is especially relevant to multinational corporations (MNCs......), which typically consist of multiple organizational (sub)cultures and whose existence depends, to a great extent, on sharing knowledge across borders. The present study examines the influence of one key component of organizational culture – organizational values – on knowledge sharing. From 2003 to 2007......, we studied Danisco, a Danish MNC, to examine the processes of espousement, enactment and internalization of a core organizational value – dialogue. In particular, we studied how these processes influence knowledge sharing behavior among employees. We collected original empirical data using content...

THE RELEVANCE OF SUBSIDIARY INITIATIVES FOR BRAZILIAN MULTINATIONALS

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Moacir de Miranda Oliveira Junior

2009-07-01

Full Text Available The purpose of this paper is to analyze relationship patterns between headquarters and subsidiaries of Brazilian Multinationals Enterprises (BrMNEs. The key construct for that investigation is Subsidiary Initiative, which comprises Subsidiary Entrepreneurial Orientation, Autonomy, Integration, Local Competitive Context and Business Network.A survey was carried out in a sample of 65 subsidiaries of 29 BrMNEs. The main outcome is that subsidiaries are highly integrated and receive Entrepreneurial Orientation from Headquarters (HQs, but Initiative is limited. Actually, the main determinants of subsidiary’s initiatives are Local Context and Business Networking in the host country. This apparent paradox may be explained by what we call ‘rebellious subsidiaries’, which take initiatives based on their business environment and connections, regardless of their HQs’ directions or delegation of autonomy.

Human factors and technology environment in multinational project: problems and solutions; Factores humanos y entorno tecnologico en proyectos multinacionales: dificultades y soluciones

Energy Technology Data Exchange (ETDEWEB)

Jardi Besa, X.; Munoz Cervantes, A.

2012-07-01

At the onset of nuclear projects in Spain, there was an import of nuclear technology. In a second phase, there was a transfer of technology. Subsequently, there was an adaptation of the technology. In this evolution, comparable to that of other countries, were involved several countries, overcoming the difficulties of human factors involved. The current nuclear projects multinationals have a new difficulty: the different industrial technological environments. This paper will address the organizational challenges of multinational engineering projects, in the type of project and the human factors of the participating companies.

The Size and Composition of Corporate Headquarters in Multinational Companies: Empirical Evidence

OpenAIRE

Collis, David J.; Young, David; Goold, Michael

2012-01-01

Based on a six-country survey of nearly 250 multinationals (MNCs), this paper is the first empirical analysis to describe the size and composition of MNC headquarters and to account for differences among them. Findings are as follows: MNC corporate headquarters are more involved in "obligatory" and value creating and control functions than in operational activities; there are no systematic differences in the determinants of the size and composition of corporate headquarters between MNCs and p...

Complete blood count risk score and its components, including RDW, are associated with mortality in the JUPITER trial.

Science.gov (United States)

Horne, Benjamin D; Anderson, Jeffrey L; Muhlestein, Joseph B; Ridker, Paul M; Paynter, Nina P

2015-04-01

Previously, we showed that sex-specific complete blood count (CBC) risk scores strongly predicted risk of all-cause mortality in multiple sets of general medical patients. This study evaluated the CBC risk score in an independent, well-studied international primary risk population of lower-risk individuals initially free from cardiovascular (CV) disease. Observational secondary analysis of a randomized trial population. The previously derived and validated CBC score was evaluated for association with all-cause mortality among CV disease-free females (n = 6568) and males (n = 10,629) enrolled for up to 5 years in the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial. Associations of the CBC score with CV mortality and with major CV disease were also tested. The CBC score predicted all-cause mortality, with univariable hazard ratio (HR) 4.83 (95% CI 3.70-6.31) for the third CBC score tertile vs. the first tertile, and HR 2.31 (CI 1.75-3.05) for the second tertile (p trend JUPITER endpoint (p trend = 0.015). c-statistics for mortality were 0.729 among all, and 0.722 and 0.750 for females and males, respectively. The CBC risk score was strongly associated with all-cause mortality among JUPITER trial participants and had good discrimination. It also predicted CV-specific outcomes. This CBC score may be useful in identifying cardiac disease-free individuals at increased risk of mortality. © The European Society of Cardiology 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Internationalisation theory and technological accumulation - an investigation of multinational affiliates in East Germany

OpenAIRE

Jindra, Bjorn

2010-01-01

This dissertation applies the theory of technology accumulation to explain the internationalisation of foreign and West German multinational enterprises (MNEs) into East Germany. This theory shifts the focus from technology transfer to the international diffusion of innovation within the MNE. It rejects the position that all MNEs offer the same technological opportunities to host economies. Yet, most of the existing empirical research on postcommunist transition economies including East Germa...

Innovation Drivers, Value Chains and the Geography of Multinational Firms in European Regions

OpenAIRE

Riccardo Crescenzi; Carlo Pietrobelli & Roberta Rabellotti

2012-01-01

"This paper investigates the geography of multinational corporations’ investments in the EU regions. The ‘traditional’ sources of location advantages (i.e. agglomeration economies, market access and labour market conditions) are considered together with innovation and socio-institutional drivers of investments, captured by means of regional social filter conditions. The introduction of a wider set of attraction factors makes is possible to empirically assess the different role played by such ...

Innovation drivers, value chains and the geography of multinational firms in European regions

OpenAIRE

Riccardo Crescenzi; Carlo Pietrobelli; Roberta Rabellotti

2012-01-01

This paper investigates the geography of multinational corporations’ investments in the EU regions. The ‘traditional’ sources of location advantages (i.e. agglomeration economies, market access and labour market conditions) are considered together with innovation and socio-institutional drivers of investments, captured by means of regional “social filter” conditions. The introduction of a wider set of attraction factors makes is possible to empirically assess the different role played by such...

Corporate governance and international business: Essays on multinational enterprises, ownership, finance and institutions

OpenAIRE

Rygh, Asmund

2016-01-01

This is an article based doctoral dissertation. Due to copyright matters, the attached pdf file only contains the mantel. This Thesis contributes to the literature on corporate governance in international business, with a focus on corporate ownership, corporate finance and institutions. It consists of five theoretical and empirical studies. Three studies focus on corporate ownership and consider, respectively, whether state ownership shields multinational enterprises (MNEs) from host-c...

Multinationals' accountability on sustainability: the evolution of third-party assurance of sustainability reports

OpenAIRE

Perego, P.; Kolk, A.

2012-01-01

In this article we explore how multinational corporations (MNCs) adopt assurance practices to develop and sustain organizational accountability for sustainability. Using a panel of Fortune Global 250 firms over a period of 10 years, we document the diffusion patterns of third-party assurance of sustainability reports. We specifically investigate how evolving auditing practices, namely diversity of assurance standards and type of assurance providers, shape the quality of sustainability assuran...

Developing Managerial Talent: Exploring the Link between Management Talent and Perceived Performance in Multinational Corporations (MNCs)

Science.gov (United States)

Sheehan, Maura

2012-01-01

Purpose: To examine the association between talent management (TM) and perceived subsidiary performance. Focus is given to the development of one key talent group--line managers--in subsidiaries of multinational corporations (MNCs). Specifically, the paper examines: whether there is a positive relationship between Management Development (MD) and…

Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis

DEFF Research Database (Denmark)

Whittle, Samuel L; Colebatch, Alexandra N; Buchbinder, Rachelle

2012-01-01

, 89 rheumatologists representing all 17 countries selected 10 clinical questions regarding the use of pain medications in IA. Bibliographic fellows undertook a systematic literature review for each question, using MEDLINE, EMBASE, Cochrane CENTRAL and 2008-09 European League Against Rheumatism (EULAR......)/ACR abstracts. Relevant studies were retrieved for data extraction and quality assessment. Rheumatologists from each country used this evidence to develop a set of national recommendations. Multinational recommendations were then formulated and assessed for agreement and the potential impact on clinical...

Multiple-level stakeholder engagement in malaria clinical trials: addressing the challenges of conducting clinical research in resource-limited settings.

Science.gov (United States)

Mtove, George; Kimani, Joshua; Kisinza, William; Makenga, Geofrey; Mangesho, Peter; Duparc, Stephan; Nakalembe, Miriam; Phiri, Kamija S; Orrico, Russell; Rojo, Ricardo; Vandenbroucke, Pol

2018-03-22

Multinational clinical trials are logistically complex and require close coordination between various stakeholders. They must comply with global clinical standards and are accountable to multiple regulatory and ethical bodies. In resource-limited settings, it is challenging to understand how to apply global clinical standards to international, national, and local factors in clinical trials, making multiple-level stakeholder engagement an important element in the successful conduct of these clinical trials. During the planning and implementation of a large multinational clinical trial for intermittent preventive treatment of malaria in pregnancy in resource-limited areas of sub-Saharan Africa, we encountered numerous challenges, which required implementation of a range of engagement measures to ensure compliance with global clinical and regulatory standards. These challenges included coordination with ongoing global malaria efforts, heterogeneity in national regulatory structures, sub-optimal healthcare infrastructure, local practices and beliefs, and perspectives that view healthcare providers with undue trust or suspicion. In addition to engagement with international bodies, such as the World Health Organization, the Malaria in Pregnancy Consortium, the Steve Biko Centre for Bioethics, and the London School of Hygiene and Tropical Medicine, in order to address the challenges just described, Pfizer Inc. and Medicines for Malaria Venture (the "Sponsoring Entities" for these studies) and investigators liaised with national- and district-level stakeholders such as health ministers and regional/local community health workers. Community engagement measures undertaken by investigators included local meetings with community leaders to explain the research aims and answer questions and concerns voiced by the community. The investigators also engaged with family members of prospective trial participants in order to be sensitive to local practices and beliefs. Engagement

Evaluating Knowledge, Attitudinal, and Behavioral Change Effects from a Multinational HIV/AIDS Education Program for Youth

Science.gov (United States)

Hardre, Patricia L.; Garcia, Fe; Apamo, Peter; Mutheu, Lucy; Ndege, Monica; Bois, Iderle

2010-01-01

This project tracked the mid-term evaluation processes, practices, and products of a multinational program to reduce at-risk behaviors for HIV/AIDS among children in Kenya, Tanzania, and Haiti. It focused on participant and community perceptions; program effectiveness in promoting abstinence and monogamy decisions; and factors supporting ongoing…

The sustainable development effects of investment by emerging-market multinationals: Shaping beneficial outcomes for home and host country

NARCIS (Netherlands)

Hendriks, G. (Guus)

2017-01-01

textabstractEmerging-market multinational enterprises (EMNEs) play an increasingly important role as investors in developing economies. When certain conditions are met, their foreign investment can contribute to host-country progress towards the Sustainable Development Goals (SDGs). Moreover,

Extreme all-cause mortality in JUPITER requires reexamination of vital records.

Science.gov (United States)

Serebruany, Victor L

2011-01-01

To compare all-cause mortality in JUPITER with other statin trials at 21 months of follow-up. Outcome advantages including all-cause mortality reduction yielded from the JUPITER trial support aggressive use of rosuvastatin and, perhaps by extension, other statins for primary prevention. Despite enrolling apparently healthy subjects and early trial termination at 21 months of mean follow-up, JUPITER revealed very high all-cause mortality in both the placebo (2.8%) and rosuvastatin (2.2%) arms. Comparison of all-cause mortality prorated for 21 months in 10 primary prevention studies and 1 acute coronary syndromes statin trial. The all-cause mortality in JUPITER was more than twice that of the average of primary prevention studies, matching well only with specific trials designed in diabetics (ASPEN or CARDS), early hypertension studies (ALLHAT-LLT) or a trial in patients with acute coronary syndromes (PROVE IT). Since the 'play of chance' is unlikely to explain these discrepancies due to excellent baseline match, excess death rates and all-cause mortality rates in both JUPITER arms must be questioned. It may be important that the study sponsor self-monitored sites. Excess all-cause mortality rates in the apparently relatively healthy JUPITER population are alarming and require independent verification. If, indeed, the surprising outcomes in JUPITER are successfully challenged, and considering established harm of statins with regard to rhabdomyolysis as well as, potentially, diabetes, millions of patients may find better and safer options for primary prevention of vascular events. Copyright © 2011 S. Karger AG, Basel.

High Performance Work System and Organizational Citizenship Behavior in Multinational Companies in Vietnam: the Mediation Effect of Career Success

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Giang Thi Huong Vu

2018-05-01

Full Text Available In this study, the relationship between high performance work system (HPWS and organizational citizenship behavior (OCB in multinational corporations (MNCs in Vietnam, a fast-developing country with highly economic growth in Asia, was investigated. Besides, the underlying mechanism of this relationship was also explored. From the social exchange approach, an underlying mediated mechanism of career success in the relationship between HPWS and OCB was hypothesized. Data collected from individual employees working in multinational companies in Vietnam was used to test the hypotheses. The research findings supported the partial mediating role of career success in the positive relationship between HPWS and OCB. In addition, research implications as well as suggestions for future research were also presented.   Bahasa Indonesia Abstrak: Dalam studi ini, hubungan antara high performance work system (HPWS dan organizational citizenship behavior (OCB di multinational corporations (MNC di Vietnam, negara cepat berkembang dengan pertumbuhan ekonomi yang sangat tinggi di Asia, ditelliti. Selain itu, mekanisme yang mendasari hubungan ini juga dieksplorasi. Dari pendekatan pertukaran sosial, mekanisme mediasi yang dimediasi dari kesuksesan karir dalam hubungan antara HPWS dan OCB dihipotesiskan. Data yang dikumpulkan dari masing-masing karyawan yang bekerja di perusahaan multinasional di Vietnam digunakan untuk menguji hipotesis. Temuan penelitian mendukung peran mediasi parsial dari kesuksesan karir dalam hubungan positif antara HPWS dan OCB. Selain itu, implikasi penelitian serta saran untuk penelitian masa depan juga disajikan.

Cross-Cultural Adjustment Process of Expatriate Families in a Multinational Organization: A Family System Theory Perspective

Science.gov (United States)

Rosenbusch, Katherine

2010-01-01

The purpose of this survey based study was to examine whether the characteristics (i.e., flexibility and cohesion) of expatriate families in a multinational corporation as measured by the Family Adaptability and Cohesion Evaluation Scale can predict cross-cultural adjustment of the expatriate (individual level of analysis) and his/her family…

Leadership challenges in multinational medical peacekeeping operations: Lessons from UNIFIL Hospital.

Science.gov (United States)

Datta, Rakesh; Khanna, Sangeeta

2017-10-01

Commanding a military multinational and multilingual healthcare facility can be a formidable task with very little margin for error. The authors were in leadership positions of UNIFIL Hospital, unique in its diversity of both staff and clientele. Experience about the challenges faced and methods adopted to overcome them will be shared. Troops from diverse backgrounds differ in their competency, and also in their attitudinal approach to situations. It is imperative for the medical commanders to identify these differences, and work towards harnessing individual strengths to form a cohesive unit. Frequent rotation of team members and thereby difficulty in adapting to new environment makes the tasks more challenging. Challenges can be broadly categorized in those dealing with functional roles (providing medical support) and command and control issues. Linguistic challenges especially in situations where professionals have to work as a coordinated unit remains a major challenge. The threat of medical errors arising out of misunderstandings is very real. Gender sensitization is essential to avoid potential unpleasant situations. Interpersonal conflict can easily go out of hand. The leadership has to be more direct and deliberate relying less on hierarchy and more on direct communication. A strict enforcement of UN standards for equipment and competence, frequent joint medical drills help to overcome interoperability issues and develop mutual confidence. Leadership in multinational UN hospitals is a demanding task with its peculiar set of challenges. A systematic and deliberate approach focused on mutual respect, flexibility and direct leadership can help medical commanders in such situations.

Optimization of RPLC Conditions for Quantitative Analysis of Atorvastatin and Rosuvastatin in Pharmaceutical Dosage Form

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Zehra ÜSTÜN

2016-05-01

Özet: Bu çalışmada, atorvastatin (ATV ve rosuvastatinin (RSV eş zamanlı tayini için ters faz sıvı kromatografi (RPLC metodu geliştirilmiş ve valide edilmiştir. Ayırmada X Terra C18 (250 mm x 4,6 mm, 5µm kolon kullanılmış ve 244 nm’ de yürütülen çalışmada akış hızı 1 mL dakika-1 olarak belirlenmiştir. Tanımlanan metodun doğrusal aralığı ATV için 3-13 µg mL-1, RSV için 4-14 µg mL-1olarak belirlenmiştir. Deneyde iç standart (IS olarak Losartan kullanılmıştır. ATV ve RSV için dedeksiyon limiti (LOD değerleri sırasıyla 0,133 ve 0,221 µg mL-1 olarak hesaplanmıştır. Kantitasyon limiti (LOQ değerleri ise ATV ve RSV için sırasıyla 0,473 ve 0,970 µg mL-1 olarak tayin edilmiştir. Elde edilen sonuçlara bakılarak, önerilen RPLC metodu ATV, RSV ve bunların farmasötik dozaj formlarının rutin analizlerinde kullanılabilir olduğu gözlemlenmiştir. Anahtar Kelimeler: Metot optimizasyonu, validasyon, eş zamanlı tayin, atorvastatin, rosuvastatin