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  1. The 2001 Bethesda System

    Directory of Open Access Journals (Sweden)

    Bergeron Christine

    2003-01-01

    Full Text Available The Bethesda system is a system of terminology for reporting the results of cervical cytology. It was developed in 1988, and is now widely used in the United States. This system was updated in April 2001. The most important modifications are the following: a elimination of the category "satisfactory but limited by", b the reintegration of benign modifications in the normal category, c "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d endocervical adenocarcinoma in situ which is now a separate entity. Low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. Recommendations have been proposed concerning automated review and ancillary testing.

  2. 75 FR 13136 - National Library of Medicine; Notice of Closed Meeting

    Science.gov (United States)

    2010-03-18

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...: National Library of Medicine, Building 38, 2nd Floor, Board Room, 8600 Rockville Pike, Bethesda, MD 20892...

  3. El Sistema Bethesda 2001 The 2001 Bethesda System

    Directory of Open Access Journals (Sweden)

    Christine Bergeron

    2003-01-01

    Full Text Available The Bethesda system is a system of terminology for reporting the results of cervical cytology. It was developed in 1988, and is now widely used in the United States. This system was updated in April 2001. The most important modifications are the following: a elimination of the category "satisfactory but limited by", b the reintegration of benign modifications in the normal category, c "atypical squamous cells of undetermined significance" is now named "atypical squamous cells" and subdivided into "atypical squamous cells of undetermined significance" and "cannot exclude high grade squamous intraepithelial lesion"; and d endocervical adenocarcinoma in situ which is now a separate entity. Low grade squamous intraepithelial lesions and high grade squamous intraepithelial cells remain unchanged. Recommendations have been proposed concerning automated review and ancillary testing.El Sistema Bethesda es un sistema de terminología para informar los resultados de citología cervical. Se inició en 1988 y en la actualidad se usa en todos los Estados Unidos de América. Este sistema se actualizó en abril de 2001. Las modificaciones más importantes son las siguientes: a eliminación de la categoría "satisfactorio pero limitado por", b se reintegraron las modificaciones benignas en la categoría normal, c la categoría "células escamosas atípicas de significado indeterminado" ahora se denomina "células escamosas atípicas", y se subdivide en "células escamosas atípicas de significado indeterminado" y "no se puede excluir una lesión escamosa de alto grado", y d adenocarcinoma endocervical in situ, que ahora es una entidad separada. Las lesiones escamosas intraepiteliales de bajo y alto grado quedan sin cambios. Se proponen recomendaciones relacionadas con el uso de la revisión automatizada y la utilización de pruebas auxiliares.

  4. Genetic Underpinnings of Alopecia Areata

    Medline Plus

    Full Text Available ... Statement Accessibility Disclaimer Digital Strategy Open Source Data Public Data Listing NIH...Turning Discovery Into Health® National Institutes of Health, 9000 Rockville Pike, Bethesda, ...

  5. To Your Health: NLM Update—MedlinePlus

    Science.gov (United States)

    ... illustrate health care May 7 2018 Transcript Genetic architecture of mental disorders April 30 2018 Transcript Why ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  6. Genetic Underpinnings of Alopecia Areata

    Medline Plus

    Full Text Available ... Accessibility Disclaimer Digital Strategy Open Source Data Public Data Listing NIH...Turning Discovery Into Health® National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 U.S. Department of Health and Human Services

  7. Genetics Home Reference: leukoencephalopathy with vanishing white matter

    Science.gov (United States)

    ... Torres C, Pröschel C. EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy. Nat Med. ... of Medicine Lister Hill National Center for Biomedical Communications 8600 Rockville Pike, Bethesda, MD 20894, USA HONCode ...

  8. MedlinePlus FAQ: Disease or Condition Information

    Science.gov (United States)

    ... on the Health Topics button on the MedlinePlus homepage. You can also find the Health Topics button ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  9. Medline Plus

    Full Text Available ... for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  10. Medline Plus

    Full Text Available ... for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated ...

  11. Introduced northern pike consumption of salmonids in Southcentral Alaska

    Science.gov (United States)

    Sepulveda, Adam J.; Rutz, David S.; Dupuis, Aaron W; Shields, Patrick A; Dunker, Kristine J.

    2015-01-01

    The impacts of introduced northern pike (Esox lucius) on salmonid populations have attracted much attention because salmonids are popular subsistence, sport and commercial fish. Concern over the predatory effects of introduced pike on salmonids is especially high in Southcentral Alaska, where pike were illegally introduced to the Susitna River basin in the 1950s. We used pike abundance, growth, and diet estimates and bioenergetics models to characterise the realised and potential consumptive impacts that introduced pike (age 2 and older) have on salmonids in Alexander Creek, a tributary to the Susitna River. We found that juvenile salmonids were the dominant prey item in pike diets and that pike could consume up to 1.10 metric tons (realised consumption) and 1.66 metric tons (potential consumption) of juvenile salmonids in a summer. Age 3–4 pike had the highest per capita consumption of juvenile salmonids, and age 2 and age 3–4 pike had the highest overall consumption of juvenile salmonid biomass. Using historical data on Chinook salmon and pike potential consumption of juvenile salmonids, we found that pike consumption of juvenile salmonids may lead to collapsed salmon stocks in Alexander Creek. Taken together, our results indicate that pike consume a substantial biomass of juvenile salmonids in Alexander Creek and that coexistence of pike and salmon is unlikely without management actions to reduce or eliminate introduced pike.

  12. Introduced northern pike predation on salmonids in southcentral Alaska

    Science.gov (United States)

    Sepulveda, Adam J.; Rutz, David S.; Ivey, Sam S.; Dunker, Kristine J.; Gross, Jackson A.

    2013-01-01

    Northern pike (Esox lucius) are opportunistic predators that can switch to alternative prey species after preferred prey have declined. This trophic adaptability allows invasive pike to have negative effects on aquatic food webs. In Southcentral Alaska, invasive pike are a substantial concern because they have spread to important spawning and rearing habitat for salmonids and are hypothesised to be responsible for recent salmonid declines. We described the relative importance of salmonids and other prey species to pike diets in the Deshka River and Alexander Creek in Southcentral Alaska. Salmonids were once abundant in both rivers, but they are now rare in Alexander Creek. In the Deshka River, we found that juvenile Chinook salmon (Oncorhynchus tshawytscha) and coho salmon (O. kisutch) dominated pike diets and that small pike consumed more of these salmonids than large pike. In Alexander Creek, pike diets reflected the distribution of spawning salmonids, which decrease with distance upstream. Although salmonids dominated pike diets in the lowest reach of the stream, Arctic lamprey (Lampetra camtschatica) and slimy sculpin (Cottus cognatus) dominated pike diets in the middle and upper reaches. In both rivers, pike density did not influence diet and pike consumed smaller prey items than predicted by their gape-width. Our data suggest that (1) juvenile salmonids are a dominant prey item for pike, (2) small pike are the primary consumers of juvenile salmonids and (3) pike consume other native fish species when juvenile salmonids are less abundant. Implications of this trophic adaptability are that invasive pike can continue to increase while driving multiple species to low abundance.

  13. 77 FR 2242 - Radio Broadcasting Services; Pike Road, AL

    Science.gov (United States)

    2012-01-17

    ...] Radio Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposed... Corporation, Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as its second local service. A staff engineering analysis indicates that Channel 228A can be allotted to Pike Road consistent...

  14. 77 FR 64792 - Radio Broadcasting Services; Pike Road, AL

    Science.gov (United States)

    2012-10-23

    ...] Radio Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposed... Corporation, Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as the community's second local service. A staff engineering analysis indicates that Channel 228A can be allotted to Pike Road...

  15. 77 FR 38761 - Radio Broadcasting Services; Pike Road, AL

    Science.gov (United States)

    2012-06-29

    ... Broadcasting Services; Pike Road, AL AGENCY: Federal Communications Commission. ACTION: Proposal rule..., Inc., proposing the allotment of Channel 228A at Pike Road, Alabama, as the community's second local... Pike Road allotment. It is the Commission's policy to refrain from making an allotment to a community...

  16. PIKE (Esox lucius L., ITS CHARACTERISTIC AND IMPORTANCE

    Directory of Open Access Journals (Sweden)

    Dobrila Habeković

    1998-07-01

    Full Text Available This paper presents data on pike spread, its morphological description and biology of species. The dynamics of the length growth in some waters is described, as well as the economic value. Only one species of the Escoidae family lives in Croatia: the pike - Esox lucius L. 1758. It inhabits plain waters in the Danube basin, and in the Adriatic basin it lives in waters of Istria, in the Vrana lake on the island of Cres and in the Gacka river. Pike growth depends on water characteristics and on food quantity. Table 1 gives data on pike growth in some waters in Croatia. In all the waters good growth of pike has been found, especially in the Lonja river. In terms of its economic value, pike is very important. It is interesting for breeding in fish farms and for catching in open waters. 22 to 23 tons of pike per year is being caught in Croatia lately.

  17. 76 FR 3642 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-20

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... evaluate grant applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD... North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person...

  18. 76 FR 369 - National Center for Research Resources; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-04

    ... applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Contact Person... grant applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852... evaluate grant applications. Place: Hilton Rockville, 1750 Rockville Pike, Plaza I, Rockville, MD 20852...

  19. Voluntary angler logbooks reveal long-term changes in a lentic pike, Esox lucius, population

    DEFF Research Database (Denmark)

    Jansen, Teunis; Arlinghaus, R.; Als, Thomas Damm

    2013-01-01

    Sixty-two years of voluntarily collected angling logbook data from a large natural Danish lake were used to 2 study variation in pike, Esox lucius L., CPUE (expressed as no. of captured per boat trip) as an index of stock size. Pike CPUE was positively related to pike release rate by anglers...... and negatively affected by certain commercial shers. The stocking of young-of-the-year pike and a shery-dependent index of perch, Perca uviatilis L., abundance (which may be pike prey or predator depending on size) did not correlate with pike CPUE. Analyses of the size distribution of pike, based on sizes...

  20. Targeting Siah2 as Novel Therapy for Metastatic Prostate Cancer

    Science.gov (United States)

    2016-10-01

    Institutes of Health 900 Rockville Pike Bethesda, MD 20892 Phone : (240) 276-6280 15 E-mail: sarah.lee@nih.gov 1 R01 CA179170-02 (PI: Ronai, Z.) 09/30...Cammie La National Institutes of Health 9000 Rockville Pike Bethesda, MD 20892 Phone : (240) 276-6323 E-mail: cl311z@nih.gov 1 R01 CA172017-02...PI: Ronai, Z.) 07/01/13–04/30/16 1.2 calendar (10.0%) NIH/NCI ATF2 Oncogenic Addiction in Melanoma Goals: The major goal of this project is to

  1. Vegetative substrates used by larval northern pike in Rainy and Kabetogama Lakes, Minnesota

    Science.gov (United States)

    Anne L. Timm; Rodney B. Pierce

    2015-01-01

    Our objective was to identify characteristics of aquatic vegetative communities used as larval northern pike nursery habitat in Rainy and Kabetogama lakes, glacial shield reservoirs in northern Minnesota. Quatrefoil light traps fished at night were used to sample larval northern pike in 11 potential nursery areas. Larval northern pike were most commonly sampled among...

  2. Second edition of 'The Bethesda System for reporting cervical cytology' – atlas, website, and Bethesda interobserver reproducibility project

    Directory of Open Access Journals (Sweden)

    Nayar Ritu

    2004-10-01

    Full Text Available Abstract A joint task force of the American Society of Cytopathology (ASC and the National Cancer Institute (NCI recently completed a 2-year effort to revise the Bethesda System "blue book" atlas and develop a complementary web-based collection of cervical cytology images. The web-based collection of images is housed on the ASC website, which went live on November 5th, 2003; it can be directly accessed at http://www.cytopathology.org/NIH/.

  3. Efficiency of the Bethesda System for Thyroid Cytopathology.

    Science.gov (United States)

    Mora-Guzmán, Ismael; Muñoz de Nova, José Luis; Marín-Campos, Cristina; Jiménez-Heffernan, José Antonio; Cuesta Pérez, Juan Julián; Lahera Vargas, Marcos; Torres Mínguez, Emma; Martín-Pérez, Elena

    2018-03-28

    Fine-needle aspiration biopsies are a key tool for preoperative assessment of thyroid nodules, and the Bethesda system is the preferred method to report cytological analysis. The purpose of this study is to assess the efficiency of the Bethesda system to identify the malignancy risk of thyroid nodules. Patients who underwent thyroid surgery between June 2010 and June 2017 were included. Samples were classified into 6categories according to rates of malignancy associated with each diagnostic category. In order to investigate the correlation between categories, a statistical analysis compared the categories with pathology reports. Diagnostic indicators were calculated as a screening test (categories IV, V, VI as true-positive) and as a method to identify malignancy (V, VI as true-positive). In a series of 522 patients, we found 184 (35.2%) malignant tumours, papillary carcinoma being the most prevalent with 155 cases (84.2%). Malignant rates for diagnostic categories were: I, 0%; II, 1.5%; III, 6.4%; IV, 31%; V, 86.5%; VI, 100%. A robust correlation was identified between categories on statistical analysis. For the «screening test» analysis, sensitivity was 98.9%, specificity 84.4%, positive predictive value 69.6%, negative predictive value 99.5%, and diagnostic accuracy 88.2%. Analysing the accuracy to detect malignancy, values were: sensitivity 98.6%, specificity 97.6%, positive predictive value 93.5%, negative predictive value 99.5%, diagnostic accuracy 97.9%. The Bethesda system is a clear and reliable approach to report thyroid cytology and therefore is an effective tool to identify malignancy risk and guide clinical management. Copyright © 2018 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  4. Medline Plus

    Full Text Available ... 2014) These webcasts are provided to the National Library of Medicine by BroadcastMed . We welcome your comments . ... MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 ...

  5. 45 CFR 170.299 - Incorporation by reference.

    Science.gov (United States)

    2010-10-01

    ... Architecture (CDA) Release 2—Continuity of Care Document (CCD), April 01, 2007, IBR approved for § 170.205. (4... § 170.207. (2) [Reserved] (f) U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894...

  6. Impacts of Northern Pike on stocked Rainbow Trout in Pactola Reservoir, South Dakota

    Science.gov (United States)

    Scheibel, Natalie C.; Dembkowski, Daniel J.; Davis, Jacob L.; Chipps, Steven R.

    2016-01-01

    Establishment of nonnative Northern Pike Esox lucius in Pactola Reservoir, South Dakota, has prompted concern among biologists about the influence of this species on the lake’s intensively managed salmonid fisheries. Ancedotal information suggests that catch rates of Rainbow Trout Oncorhynchus mykiss have declined while mean size and abundance of Northern Pike has increased, although quantitative information on diet and growth of the Northern Pike population is lacking. To address potential interactions between Northern Pike and Rainbow Trout, we assessed size-dependent predation by Northern Pike on Rainbow Trout and determined the relative energetic contribution of stocked Rainbow Trout to Northern Pike growth using bioenergetics modeling. Stable isotopes combined with traditional diet analyses revealed that smaller Northern Pike (Trout contributed less than 10% to their annual energy consumption. In contrast, larger Northern Pike (≥600 mm TL) consumed primarily Rainbow Trout, which accounted for 56% of their annual energy consumption. Combining estimates of Northern Pike predation with production costs of catchable-size Rainbow Trout revealed that annual economic losses ranged from US$15,259 to $24,801 per year. Over its lifespan, an age-10 Northern Pike was estimated to consume ~117 Rainbow Trout worth approximately $340. Thus, Northern Pike predation substantially influences salmonid management initiatives and is likely a primary factor contributing to reduced Rainbow Trout abundance and return to anglers in Pactola Reservoir. Strategies for reducing Northern Pike predation on Rainbow Trout include increasing the size of stocked fish or altering the timing and spatial distribution of stocking events.

  7. Susceptibility of pike Esox lucius to a panel of Ranavirus isolates

    DEFF Research Database (Denmark)

    Jensen, Ann Britt Bang; Ersbøll, A. K.; Ariel, Ellen

    2009-01-01

    In order to study the pathogenicity of ranaviruses to a wild European freshwater fish species, pike Esox lucius fry were challenged with the following Ranavirus isolates: epizootic haematopoietic necrosis virus (EHNV), European sheatfish virus (ESV), European catfish virus (ECV), pike-perch irido......In order to study the pathogenicity of ranaviruses to a wild European freshwater fish species, pike Esox lucius fry were challenged with the following Ranavirus isolates: epizootic haematopoietic necrosis virus (EHNV), European sheatfish virus (ESV), European catfish virus (ECV), pike...

  8. Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

    Science.gov (United States)

    Umar, Asad; Boland, C. Richard; Terdiman, Jonathan P.; Syngal, Sapna; de la Chapelle, Albert; Rüschoff, Josef; Fishel, Richard; Lindor, Noralane M.; Burgart, Lawrence J.; Hamelin, Richard; Hamilton, Stanley R.; Hiatt, Robert A.; Jass, Jeremy; Lindblom, Annika; Lynch, Henry T.; Peltomaki, Païvi; Ramsey, Scott D.; Rodriguez-Bigas, Miguel A.; Vasen, Hans F. A.; Hawk, Ernest T.; Barrett, J. Carl; Freedman, Andrew N.; Srivastava, Sudhir

    2010-01-01

    Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and because of the need for a better understanding of the clinical and histologic manifestations of HNPCC, the National Cancer Institute hosted an international workshop on HNPCC in 1996, which led to the development of the Bethesda Guidelines for the identification of individuals with HNPCC who should be tested for MSI. To consider revision and improvement of the Bethesda Guidelines, another HNPCC workshop was held at the National Cancer Institute in Bethesda, MD, in 2002. In this commentary, we summarize the Workshop presentations on HNPCC and MSI testing; present the issues relating to the performance, sensitivity, and specificity of the Bethesda Guidelines; outline the revised Bethesda Guidelines for identifying individuals at risk for HNPCC; and recommend criteria for MSI testing. PMID:14970275

  9. Isolation of an iridovirus from pike-perch Stizostedion lucioperca

    DEFF Research Database (Denmark)

    Tapiovaara, H.; Olesen, Niels Jørgen; Linden, J.

    1998-01-01

    We have isolated a large virus from pike-perch Stizostedion lucioperca fingerlings with no signs of disease. The biochemical, structural, and serological properties of this newly isolated virus suggest that it belongs to the family Iridoviridae. The virus multiplied and was cytopathogenic...... fish iridoviruses. It is an enveloped icosahedral DNA virus. The diameter of the nucleocapsid in thin sections was 127 +/- 3 nm; in negatively stained preparates the size of the enveloped virus varied from 147 to 187 nm. In immunofluorescence the virus was stained by rabbit antisera against EHN...

  10. The 2017 Bethesda System for Reporting Thyroid Cytopathology.

    Science.gov (United States)

    Cibas, Edmund S; Ali, Syed Z

    2017-11-01

    The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established a standardized, category-based reporting system for thyroid fine-needle aspiration (FNA) specimens. The 2017 revision reaffirms that every thyroid FNA report should begin with one of six diagnostic categories, the names of which remain unchanged since they were first introduced: (i) nondiagnostic or unsatisfactory; (ii) benign; (iii) atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS); (iv) follicular neoplasm or suspicious for a follicular neoplasm; (v) suspicious for malignancy; and (vi) malignant. There is a choice of two different names for some of the categories. A laboratory should choose the one it prefers and use it exclusively for that category. Synonymous terms (e.g., AUS and FLUS) should not be used to denote two distinct interpretations. Each category has an implied cancer risk that ranges from 0% to 3% for the "benign" category to virtually 100% for the "malignant" category, and, in the 2017 revision, the malignancy risks have been updated based on new (post 2010) data. As a function of their risk associations, each category is linked to updated, evidence-based clinical management recommendations. The recent reclassification of some thyroid neoplasms as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has implications for the risk of malignancy, and this is accounted for with regard to diagnostic criteria and optional notes. Such notes can be useful in helping guide surgical management.

  11. Effects of angling and manual handling on pike behaviour investigated by high-resolution positional telemetry

    DEFF Research Database (Denmark)

    Baktoft, Henrik; Aarestrup, Kim; Berg, Søren

    2013-01-01

    Human disturbances such as angling and manual handling may have long-term effects on the behaviour of pike, Esox lucius L., an ecologically important species. Using continuous high-resolution positional telemetry, this study compared the swimming activity of handled and unhandled pike in a small...

  12. METHYLMERCURY BIOACCUMULATION DEPENDENCE ON NORTHERN PIKE AGE AND SIZE IN TWENTY MINNESOTA LAKES

    Science.gov (United States)

    Mercury accumulation in northern pike muscle tissue (fillets) was found to be directly related to fish age and size. Measurements were made on 173 individual northern pike specimens from twenty lakes across Minnesota. Best fit regressions of mercury fillet concentration (wet wt.)...

  13. Fishing for Northern Pike in Minnesota: A comparison of anglers and dark house spearers

    Science.gov (United States)

    Schroeder, Susan A.; Fulton, David C.

    2014-01-01

    In order to project fishing effort and demand of individuals targeting Northern Pike Esox lucius in Minnesota, it is important to understand the catch orientations, management preferences, and site choice preferences of those individuals. Northern Pike are specifically targeted by about 35% of the approximately 1.5 million licensed anglers in Minnesota and by approximately 14,000–15,000 dark house spearers. Dark house spearing is a traditional method of harvesting fish through the ice in winter. Mail surveys were distributed to three research strata: anglers targeting Northern Pike, dark house spearing license holders spearing Northern Pike, and dark house spearing license holders angling for Northern Pike. Dark house spearers, whether spearing or angling, reported a stronger orientation toward keeping Northern Pike than did anglers. Anglers reported a stronger orientation toward catching large Northern Pike than did dark house spearers when spearing or angling. Northern Pike regulations were the most important attribute affecting site choice for respondents in all three strata. Models for all strata indicated a preference for lakes without protected slot limits. However, protected slot limits had a stronger negative influence on lake preference for dark house spearing licensees (whether spearing or angling) than for anglers.

  14. Susceptibility of pike-perch Sander lucioperca to a panel of ranavirus isolates

    DEFF Research Database (Denmark)

    Jensen, Britt Bang; Holopainen, Riikka; Tapiovaara, Hannele

    2011-01-01

    The host range of ranaviruses was investigated by challenging pike-perch (Sander lucioperca) with the following ranavirus isolates: epizootic haematopoietic necrosis virus (EHNV), European sheatfish virus (ESV), European catfish virus (ECV), pike-perch iridovirus (PPIV), short-finned eel virus...

  15. Evaluating stocking of YOY pike Esox lucius as a tool in the restoration of shallow lakes

    DEFF Research Database (Denmark)

    Skov, Christian; Nilsson, P.A.

    2007-01-01

    from field surveys in eight study lakes stocked with YOY pike as well as from the literature. 3. Our model showed that all parameters studied were important for predicting the effects of pike stocking on cyprinids. In particular, body size at stocking, cyprinid production and pike survival were good...... as an appropriate and reliable tool for restoration programmes in shallow lakes, and indicate that when used efforts should be made to optimize the timing of stocking in relation to YOY cyprinid production and to increase the stocking body size of the pike.......1. Stocking of piscivores in shallow, eutrophicated lakes to reduce cyprinid densities is a common approach in lake restorations. Young-of-the-year (YOY) pike Esox lucius are frequently used to reduce cyprinid densities, but their effectiveness is equivocal. This study uses a simple model to assess...

  16. Environmental conditions and intraspecific interference: unexpected effects of turbidity on pike (Esox lucius) foraging

    DEFF Research Database (Denmark)

    Nilsson, P.A.; Jacobsen, Lene; Berg, Søren

    2009-01-01

    on pike foraging alone or among conspecifics in different levels of water turbidity, we expected high turbidity to decrease the perceived risk of intraspecific interactions among pike, and thereby decrease the strength of interference, as turbidity would decrease the visual contact between individuals...... and act as a refuge from behavioural interactions. The results show that this is not the case, but suggest that interference is induced instead of reduced in high turbidity. Per capita foraging rates do not differ between pike foraging alone or in groups in our clear and moderately turbid treatments......, indicating no effect of interference. As high turbidity enhances prey consumption for pike individuals foraging alone, but does not have this effect for pike in groups, high turbidity induces the relative interference effect. We suggest that future evaluations of the stabilizing effects of interference...

  17. Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid

    Directory of Open Access Journals (Sweden)

    Simon Sung

    2017-01-01

    Full Text Available Background: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal and Bethesda category IV (Beth-IV thyroid follicular lesions, which carry a 15%–30% risk of malignancy and are often followed up with surgical resection. Methods: A search was performed to identify “parathyroid” diagnoses in parathyroid/thyroid-designated fine-needle aspirations (FNAs and Beth-IV thyroid FNAs (follicular and Hurthle cell, all with diagnostic confirmation through surgical pathology, immunocytochemical stains, Afirma® analysis, and/or clinical correlation. Unique cytomorphologic features were scored (0-3 or noted as present versus absent. Statistical analysis was performed using R 3.3.1 software. Results: We identified five FNA cases with clinical suspicion of parathyroid neoplasm, hyperthyroidism, or thyroid lesion that had an eventual final diagnosis of the parathyroid lesion (all female; age 20–69 years and 12 Beth-IV diagnoses (11 female, 1 male; age 13–64 years. The following cytomorphologic features are useful distinguishing features (P value: overall pattern (0.001, single cells (0.001, cell size compared to red blood cell (0.01, nuclear irregularity (0.001, presence of nucleoli (0.001, nuclear-to-cytoplasmic ratio (0.007, and nuclear chromatin quality (0.028. Conclusions: There are cytomorphologic features that distinguish Beth-IV thyroid lesions and (intrathyroidal parathyroid. These features can aid in rendering correct diagnoses and appropriate management.

  18. West Pike Story: a dated phylogeography of Esox spp. (Actinopterygii, Esocidae

    Directory of Open Access Journals (Sweden)

    Gael P. J. Denys

    2015-11-01

    The results distinguish the 3 pike species as well as the 3 lineages of E. lucius from Skog et al. (2014. The presence of individuals from the South-European and circumpolar lineages might result from stocking operations. Finally, molecular dating with reanalysis old fossil calibrations places the European pikes diversification during the late Miocene (E. aquitanicus vs. the others, the late Pliocene (E. cisalpinus vs. E. lucius, and the Pleistocene ice ages (E. lucius lineages. Pike restocking should take into account the genetics of the fish in order to preserve these species with high economical and patrimonial value.

  19. Summary of Information Presented at an NRC-Sponsored Low-Power Shutdown Public Workshop, April 27, 1999, Rockville, Maryland

    International Nuclear Information System (INIS)

    Wheeler, Timothy A.; Whitehead, Donnie W.; Lois, Erasmia

    1999-01-01

    This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations

  20. Summary of Information Presented at an NRC-Sponsored Low-Power Shutdown Public Workshop, April 27, 1999, Rockville, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Wheeler, Timothy A.; Whitehead, Donnie W.; Lois, Erasmia

    1999-07-01

    This report summarizes a public workshop that was held on April 27, 1999, in Rockville, Maryland. The workshop was conducted as part of the US Nuclear Regulatory Commission's (NRC) efforts to further develop its understanding of the risks associated with low power and shutdown operations at US nuclear power plants. A sufficient understanding of such risks is required to support decision-making for risk-informed regulation, in particular Regulatory Guide 1.174, and the development of a consensus standard. During the workshop the NRC staff discussed and requested feedback from the public (including representatives of the nuclear industry, state governments, consultants, private industry, and the media) on the risk associated with low-power and shutdown operations.

  1. Baseline assessment of groundwater quality in Pike County, Pennsylvania, 2015

    Science.gov (United States)

    Senior, Lisa A.; Cravotta, Charles A.

    2017-12-29

    The Devonian-age Marcellus Shale and the Ordovician-age Utica Shale, which have the potential for natural gas development, underlie Pike County and neighboring counties in northeastern Pennsylvania. In 2015, the U.S. Geological Survey, in cooperation with the Pike County Conservation District, conducted a study that expanded on a previous more limited 2012 study to assess baseline shallow groundwater quality in bedrock aquifers in Pike County prior to possible extensive shale-gas development. Seventy-nine water wells ranging in depths from 80 to 610 feet were sampled during June through September 2015 to provide data on the presence of methane and other aspects of existing groundwater quality in the various bedrock geologic units throughout the county, including concentrations of inorganic constituents commonly present at low values in shallow, fresh groundwater but elevated in brines associated with fluids extracted from geologic formations during shale-gas development. All groundwater samples collected in 2015 were analyzed for bacteria, dissolved and total major ions, nutrients, selected dissolved and total inorganic trace constituents (including metals and other elements), radon-222, gross alpha- and gross beta-particle activity, dissolved gases (methane, ethane, and propane), and, if sufficient methane was present, the isotopic composition of methane. Additionally, samples from 20 wells distributed throughout the county were analyzed for selected man-made volatile organic compounds, and samples from 13 wells where waters had detectable gross alpha activity were analyzed for radium-226 on the basis of relatively elevated gross alpha-particle activity.Results of the 2015 study show that groundwater quality generally met most drinking-water standards for constituents and properties included in analyses, but groundwater samples from some wells had one or more constituents or properties, including arsenic, iron, manganese, pH, bacteria, sodium, chloride, sulfate

  2. The northern pike, a prized native but disastrous invasive: Chapter 14

    Science.gov (United States)

    Rutz, David; Massengill, Robert L.; Sepulveda, Adam; Dunker, Kristine J.

    2018-01-01

    As the chapters in this book describe, the northern pike Esox lucius Linneaus, 1758 is a fascinating fish that plays an important ecological role in structuring aquatic communities (chapter 8), has the capacity to aid lake restoration efforts (chapter 11), and contributes substantially to local economies, both as a highlysought after sport fish (chapter 12) and as a commercial fishing resource (chapter 13). However, despite the magnificent attributes of this fish, there is another side to its story. Specifically, what happens when northern pike, a highly efficient predator, becomes established outside its natural range? To explore this question, this chapter will investigate observed consequences from many locations where northern pike (hereafter referred to as “pike”) have been introduced and discuss potential reasons why pike, under the right circumstances, can be considered an invasive species.

  3. BIOLOGICAL CHARACTERISTICS OF PIKE (ESOX LUCIUS LINNAEUS, 1758 OF THE LOWER DNIEPER RIVER IN CURRENT CONDITIONS

    Directory of Open Access Journals (Sweden)

    K. Geina

    2015-03-01

    Full Text Available Purpose. To analyze major biological characteristics of pike (Esox lucius L., 1758 stock in the lower Dnieper River in the conditions of transformed flow. Methodology. Collection of the ichthyological material was carried out in the lower Dnieper River from commercial fishing gears, including beach seines, drag seines, fyke-nets. Field, laboratory processing of samples and mathematical analysis of the obtained results were carried out according to generally accepted methods and guidelines with some assumptions regarding the duration of pike fattening directly in the lower Dnieper River. Findings. Recent years, there is an increase in the specific weight of younger age groups in the pike stock in the lower Dnieper River. Analysis of linear growth indicates on satisfactory environmental conditions for pike. Current commercial contingent of pike is based on size classes of 46–50 cm versus 22–32 cm in the first half of the last century. Reproductive properties of pike, in particular fecundity, egg size and maturity coefficients did not virtually change compared to those of the last century. Depending on linear sizes, the absolute fecundity is 32.3–155.8 thousand eggs and the maturation coefficient is 11.1–15.7%. Morphologic variability of pike in the lower Dnieper River during the period from 1980s to the present time was observed for plastic features, which characterized fin sizes. Sexual dimorphism in current conditions was observed only for maximum body depth. No significant differences for other plastic features between males and females of pike in the lower Dnieper River. Originality. The data on biological characteristics of pike stock from the lower Dnieper River have been updated. Current fecundity of females of different size groups recorded in commercial catches was been determined. An analysis of morphological variability of major plastic features of pike in the process of the transformation of the Dnieper River flow has been

  4. Short-term salinity tolerance of northern pike, Esox lucius , fry, related to temperature and size

    DEFF Research Database (Denmark)

    Jacobsen, Lene; Skov, Christian; Koed, Anders

    2007-01-01

    The short-term tolerances of northern pike, Esox lucius L., fry reared in a freshwater hatchery, to salinity were examined in the laboratory. Survival of two size groups of pike fry (mean length 21 +/- 2 mm SD and 37 +/- 4 mm SD) was examined over 72- to 96-h periods at 9-14 ppt salinity in combi......The short-term tolerances of northern pike, Esox lucius L., fry reared in a freshwater hatchery, to salinity were examined in the laboratory. Survival of two size groups of pike fry (mean length 21 +/- 2 mm SD and 37 +/- 4 mm SD) was examined over 72- to 96-h periods at 9-14 ppt salinity...... in combination with temperatures of 10, 14 and 18 degrees C. A parametric survival model found a significant correlation between survival of pike fry and temperature and salinity, respectively. L(C)50 values after 72 h were between 11.2 and 12.2 ppt, being lowest at 10 degrees C. Pike fry did not survive more...

  5. Pike River Mine Disaster: Systems-Engineering and Organisational Contributions

    Directory of Open Access Journals (Sweden)

    Dirk J. Pons

    2016-10-01

    Full Text Available The Pike River mine (PRM, an underground coal mine in New Zealand (NZ, exploded in 2010. This paper analyses the causes of the disaster, with a particular focus on the systems engineering and organisational contributions. Poor systems-engineering contributed via poorly designed ventilation, use of power-electronics underground, and placement of the main ventilation fan underground. Management rushed prematurely into production even though the technology development in the mine was incomplete. Investment in non-productive infrastructure was deprioritised resulting in inadequate ventilation, and the lack of a viable second emergency egress. The risk assessments were deficient, incomplete, or not actioned. Warnings and feedback from staff were ignored. Risk arises as a consequence of the complex interactions between the components of the sociotechnical system. Organisations will need to strengthen the integrity of their risk management processes at engineering, management, and board levels. The systems engineering perspective shows the interacting causality between the engineering challenges (ventilation, mining method, electrical power, project deliverables, management priorities, organisational culture, and workers’ behaviour. Use of the barrier method provides a new way to examine the risk-management strategies of the mine. The breakdowns in organisational safety management systems are explicitly identified.

  6. Transactions of the twenty-third water reactor safety information meeting to be held at Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995

    International Nuclear Information System (INIS)

    Monteleone, S.

    1995-09-01

    This report contains summaries of papers on reactor safety research to be presented at the 23rd Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory, Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningful discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session

  7. Transactions of the twenty-third water reactor safety information meeting to be held at Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995

    Energy Technology Data Exchange (ETDEWEB)

    Monteleone, S. [comp.

    1995-09-01

    This report contains summaries of papers on reactor safety research to be presented at the 23rd Water Reactor Safety Information Meeting at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23--25, 1995. The summaries briefly describe the programs and results of nuclear safety research sponsored by the Office of Nuclear Regulatory, Research, US NRC. Summaries of invited papers concerning nuclear safety issues from US government laboratories, the electric utilities, the nuclear industry, and from foreign governments and industry are also included. The summaries have been compiled in one report to provide a basis for meaningful discussion and information exchange during the course of the meeting and are given in the order of their presentation in each session.

  8. Pike (Esox lucius L.) on the edge: consistent individual movement patterns in transitional waters of the western Baltic

    DEFF Research Database (Denmark)

    Jacobsen, Lene; Bekkevold, Dorte; Berg, Søren

    2017-01-01

    salinity) would perform spawning- and feeding-related movements between areas with different salinity regimes. Twenty-two pike were caught prior to spawning, tagged with acoustic transmitters, and their movements were tracked for 18 months. Pike showed two main patterns of movements that were consistent......-varied with either length or condition factor. Despite the fact that the lagoon’s salinity is close to the reported upper limit for pike egg development, results indicated that all pike spawned in the lagoon. Correspondingly, genetic data showed that all fish belonged to the same reproductive population unit...

  9. Preliminary assessment of the impact of fluctuating water levels on northern pike in Reindeer Lake

    International Nuclear Information System (INIS)

    Chen, M.

    1993-03-01

    Reindeer Lake in north eastern Saskatchewan regulates water levels for the Island Falls hydroelectric power plant. Since inception of the Whitesand Dam on the lake, there have been concerns that fluctuating water levels could be adversely impacting the habitat and population of northern pike in the lake. The extent of water level fluctuations during the pike spawning period of Reindeer Lake and its effect on spawning success was investigated. Since construction of the Whitesand Dam in 1942 Reindeer Lake water levels have averaged ca 1.71 m higher than had the dam not existed, creating ca 430 km 2 of new surface area. Much of this area is shallow water and prone to growth of aquatic vegetation, which is suitable spawning and nursery habitat for northern pike. Annual and periodic water level fluctuations of Reindeer Lake have been higher than under natural conditions. During northern pike spawning and nursing periods, water levels in the lake have generally increased, in 60 out of 64 y. It is concluded that operation of the dam has not caused any direct negative impacts on the northern pike habitat in the lake. 2 refs., 4 figs., 4 tabs

  10. Selective exploitation of large pike Esox lucius-Effects on mercury concentrations in fish populations

    International Nuclear Information System (INIS)

    Sharma, Chhatra Mani; Borgstrom, Reidar; Huitfeldt, Jorgen Sinkaberg; Rosseland, Bjorn Olav

    2008-01-01

    The present study outlines two main trends of mercury transfer patterns through the fish community: 1) the Hg concentrations increase with increase in the trophic level, with top predators having the highest concentrations, and 2) a fast growth rate may dilute the concentrations of Hg in fish muscle tissue (growth biodilution). In 2004, an extensive reduction in number of large pike (Esox lucius L.), was initiated by selective gillnet fishing in Lake Arungen, Norway, in order to increase the pike recruitment due to an expected reduction in cannibalism. In this connection, total mercury (THg) concentrations in the fish community were studied both before (2003) and after (2005) the removal of large pike. The δ 15 N signatures and stomach content analyses indicated that pike and perch (Perca fluviatilis L.) occupied the highest trophic position, while roach (Rutilus rutilus (L.)) was at the lower level, and rudd (Scardinius erythrophthalmus L.) at the lowest. The piscivores, pike and perch, had the highest concentrations of THg. The biomagnification rate of THg through the food web in the fish community was 0.163 ( per milleδ 15 N), with the highest uptake rate (0.232) in perch. A significant decrease in THg concentrations was found in all fish species in 2005 compared to 2003. Removal of the top predators in an Hg contaminated lake might thus be an important management tool for reducing Hg levels in fish, thereby reducing health risk to humans

  11. Technique of the biomechanical analysis of execution of upward jump piked

    Directory of Open Access Journals (Sweden)

    Nataliya Batieieva

    2016-12-01

    Full Text Available Purpose: the biomechanical analysis of execution of upward jump piked. Material & Methods: the following methods of the research were used: theoretical analysis and synthesis of data of special scientific and methodical literature; photographing, video filming, biomechanical computer analysis, pedagogical observation. Students (n=8 of the chair of national choreography of the department of choreographic art of Kiev national university of culture and art took part in carrying out the biomechanical analysis of execution of upward jump piked. Results: the biomechanical analysis of execution of upward jump piked is carried out, the kinematic characteristics (way, speed, acceleration, effort of the general center of weight (GCW and center of weight (CW of biolinks of body of the executor are received (feet, shins, hips, shoulder, forearm, hands. Biokinematic models (phases are constructed. Power characteristics are defined – mechanical work and kinetic energy of links of legs and hands at execution of upward jump piked. Conclusions: it is established that the technique of execution of upward jump piked considerably influences the level of technical training of the qualified sportsmen in gymnastics (sports, in aerobic gymnastics (aerobics, diving and dancing sports.

  12. Trophic ecology of largemouth bass and northern pike in allopatric and sympatric assemblages in northern boreal lakes

    Science.gov (United States)

    Soupir, Craig A.; Brown, Michael L.; Kallemeyn, Larry W.

    2000-01-01

    Largemouth bass (Micropterus salmoides) and northern pike (Esox lucius) are top predators in the food chain in most aquatic environments that they occupy; however, limited information exists on species interactions in the northern reaches of largemouth bass distribution. We investigated the seasonal food habits of allopatric and sympatric assemblages of largemouth bass and northern pike in six interior lakes within Voyageurs National Park, Minnesota. Percentages of empty stomachs were variable for largemouth bass (38-54%) and northern pike (34.7-66.7%). Fishes (mainly yellow perch, Perca flavescens) comprised greater than 60% (mean percent mass, MPM) of the northern pike diet during all seasons in both allopatric and sympatric assemblages. Aquatic insects (primarily Odonata and Hemiptera) were important in the diets of largemouth bass in all communities (0.0-79.7 MPM). Although largemouth bass were observed in the diet of northern pike, largemouth bass apparently did not prey on northern pike. Seasonal differences were observed in the proportion of aquatic insects (P = 0.010) and fishes (P = 0.023) in the diets of northern pike and largemouth bass. Based on three food categories, jackknifed classifications correctly classified 77 and 92% of northern pike and largemouth bass values, respectively. Percent resource overlap values were biologically significant (greater than 60%) during at least one season in each sympatric assemblage, suggesting some diet overlap.

  13. Using accelerometry to quantify prey attack and handling behaviours in piscivorous pike Esox lucius

    DEFF Research Database (Denmark)

    Deurs, Mikael van; Andersson, A.; Vinterstare, J.

    2017-01-01

    Accelerometer technology was used to evaluate behaviours in the teleost ambush predator pike Esox lucius foraging on crucian carp Carassius carassius. Automated rule-based estimates of prey-size determined handling time were obtained and are compared with video-recorded behaviours. Solutions to t...... attachment and the limitations imposed by battery-time and data-logging capacities are evaluated......Accelerometer technology was used to evaluate behaviours in the teleost ambush predator pike Esox lucius foraging on crucian carp Carassius carassius. Automated rule-based estimates of prey-size determined handling time were obtained and are compared with video-recorded behaviours. Solutions to tag...

  14. 75 FR 47820 - Generic Drug User Fee; Public Meeting; Request for Comments

    Science.gov (United States)

    2010-08-09

    ... Hilton Washington DC/ Rockville and Executive Meeting Center, 1750 Rockville Pike, Rockville, MD 20852... 17, 2010, at the Hilton Washington DC/Rockville and Executive Meeting Center, see Location). In...

  15. Diagnostic accuracy of circulating thyrotropin receptor messenger RNA combined with neck ultrasonography in patients with Bethesda III-V thyroid cytology.

    Science.gov (United States)

    Aliyev, Altay; Patel, Jinesh; Brainard, Jennifer; Gupta, Manjula; Nasr, Christian; Hatipoglu, Betul; Siperstein, Allan; Berber, Eren

    2016-01-01

    The aim of this study was to analyze the usefulness of thyrotropin receptor messenger RNA (TSHR-mRNA) combined with neck ultrasonography (US) in the management of thyroid nodules with Bethesda III-V cytology. Cytology slides of patients with a preoperative fine needle aspiration (FNA) and TSHR-mRNA who underwent thyroidectomy between 2002 and 2011 were recategorized based on the Bethesda classification. Results of thyroid FNA, TSHR-mRNA, and US were compared with the final pathology. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. There were 12 patients with Bethesda III, 112 with Bethesda IV, and 58 with Bethesda V cytology. The sensitivity of TSHR-mRNA in predicting cancer was 33%, 65%, and 79 %, and specificity was 67%, 66%, and 71%, for Bethesda III, IV, and V categories, respectively. For the same categories, the PPV of TSHR-mRNA was 25%, 33%, and 79%, respectively; whereas the NPV was 75%, 88%, and 71%, respectively. The addition of neck US to TSHR-mRNA increased the NPV to 100% for Bethesda III, and 86%, for Bethesda IV, and 82% for Bethesda V disease. This study documents the potential usefulness of TSHR-mRNA for thyroid nodules with Bethesda III-V FNA categories. TSHR-mRNA may be used to exclude Bethesda IV disease. A large sample analysis is needed to determine its accuracy for Bethesda category III nodules. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. The Bethesda system for reporting thyroid fine needle aspirates: A cytologic study with histologic follow-up

    Directory of Open Access Journals (Sweden)

    Santosh Kumar Mondal

    2013-01-01

    Conclusions: Reviewing the thyroid FNAs with the Bethesda system allowed a more specific cytological diagnosis. In this study, the distribution of cases in the Bethesda categories differed from some studies, with the number of benign cases being higher and the number of non-diagnostic and AFLUS cases being lower. The malignancy risk for each category correlated well with other studies. The Bethesda system thus allows standardization in reporting, improves perceptions of diagnostic terminology between cytopathologists and clinicians, and leads to more consistent management approaches.

  17. Pike Esox Lucius Distribution and Feeding Comparisons in Natural and Historically Channelized River Sections

    Directory of Open Access Journals (Sweden)

    Ivanovs Kaspars

    2016-12-01

    Full Text Available During the last century a large portion of small and medium-sized rivers in Latvia were channelized, hydroelectric power stations were also built, which led to changes in the hydrodynamic conditions, geomorphological structure, as well as a change in the fish fauna. Fish are an integral part of any community in natural or man-made bodies of water. They actively participate in maintaining the system, balancing/equilibrium, energy, substance transformation and biomass production. They are able to influence other organisms in the ecosystem in which they live. The aim of the paper “Pike distribution and feeding comparisons in natural and historically channelized river sections” is to find out what pike feed on in different environments in Latvian rivers, such as natural and straightened river sections, as well as what main factors determine the composition of their food. Several points were assessed during the course of the study: the impact of environmental conditions on the feeding habits and the distribution of pike; the general feeding habits of predators in Latvian rivers; the feeding differences of predators in natural and straightened river sections; and lastly, rhithral and pothamal habitats were compared. The study was based on data from 2014 and 2015 on fish fauna monitoring. During the study, 347 pike were collected from 136 plots using electrofishing method.

  18. Behavioural interactions between prey (trout smolts) and predators (pike and pikeperch) in an impounded river

    DEFF Research Database (Denmark)

    Jepsen, Niels; Pedersen, Susanne; Thorstad, E.

    2000-01-01

    pikeperch and few female pike have adjusted their behaviour to predation on smolts during the smolt run. The smolt predation in this man-made reservoir is higher than in natural lakes, probably due to the changed physical environment and introduced predators, such as pikeperch. The outlet sluice practice...

  19. Development of a bioassay to assess the toxicity of oil sands sediments to pike (Esox lucius)

    Energy Technology Data Exchange (ETDEWEB)

    Turcotte, D.; Yuan, H.; Tumber, V.; Parrott, J. [Environment Canada, Ottawa, ON (Canada); Raine, J. [Saskatchewan Univ., Saskatoon, SK (Canada)

    2010-07-01

    Pike (Esox lucius) are a commercially sought fish species that inhabit the Athabasca River, which flows through the Athabasca oil sands. The fish are exposed to natural sources of bitumen from the McMurray formation. This study was conducted to design and implement a daily-renewal bioassay to assess the toxicity of oil sands to this fish species and to obtain information regarding the development of pike exposed to bitumen. Eggs were collected and fertilized with milt from spawning wild pike captured from Lake Diefenbaker in Saskatchewan. The fertilized eggs were exposed to different concentrations of sediments or culture water only (negative controls) until complete yolk absorption of control fish, approximately 15 days post-hatch. For the rest of the experiment, brine shrimp were fed to the walleye embryos every day after hatching. The developing fish were examined for morphological deformities, survival, hatching success, and changes in weight and length. The research findings indicated that pike is less sensitive than walleye and fathead minnow to the toxicity of oil sands sediments.

  20. Pike Esox Lucius Distribution and Feeding Comparisons in Natural and Historically Channelized River Sections

    Science.gov (United States)

    Ivanovs, Kaspars

    2016-12-01

    During the last century a large portion of small and medium-sized rivers in Latvia were channelized, hydroelectric power stations were also built, which led to changes in the hydrodynamic conditions, geomorphological structure, as well as a change in the fish fauna. Fish are an integral part of any community in natural or man-made bodies of water. They actively participate in maintaining the system, balancing/equilibrium, energy, substance transformation and biomass production. They are able to influence other organisms in the ecosystem in which they live. The aim of the paper "Pike distribution and feeding comparisons in natural and historically channelized river sections" is to find out what pike feed on in different environments in Latvian rivers, such as natural and straightened river sections, as well as what main factors determine the composition of their food. Several points were assessed during the course of the study: the impact of environmental conditions on the feeding habits and the distribution of pike; the general feeding habits of predators in Latvian rivers; the feeding differences of predators in natural and straightened river sections; and lastly, rhithral and pothamal habitats were compared. The study was based on data from 2014 and 2015 on fish fauna monitoring. During the study, 347 pike were collected from 136 plots using electrofishing method.

  1. Marking pike fry otoliths with alizarin complexone and strontium : an evaluation of methods

    DEFF Research Database (Denmark)

    Skov, Christian; Grønkjær, P.; Nielsen, C.

    2001-01-01

    Laboratory experiments demonstrated that both alizarin complexone and strontium are useful in mass marking of pike Esox lucius fry otoliths. Visual detection of alizarin complexone marks was considered more reliable than the quantitative analysis of strontium for differentiating marked and unmarked...

  2. Suppression of invasive topmouth gudgeon Pseudorasbora parva by native pike Esox lucius in ponds

    NARCIS (Netherlands)

    Lemmens, P.; Mergeay, J.; Vanhove, T.; De Meester, L.; Declerck, S.A.J.

    2015-01-01

    1. Asian topmouth gudgeon Pseudorasbora parva has been recognized as a highly invasive cyprinid fish species in Europe that can present risk to native fish communities. 2. The present study aimed to investigate whether a native piscivorous fish, pike Esox lucius, is able to reduce the establishment

  3. Pike ( Esox lucius L.) stocking as a biomanipulation tool .1. Effects on the fish population in Lake Lyng, Denmark

    DEFF Research Database (Denmark)

    Berg, Søren; Jeppesen, E.; Søndergaard, M.

    1997-01-01

    significantly by 64 to 97%. In 1991 ruffe disappeared completely. The pike stocking did not affect the density of perch significantly. The growth of pike was high and also the growth of perch increased significantly from 1990 to 1991 (p ... of the piscivorous perch increased due to increased Secchi depth and a continuous high density of 0+ planktivores in the pelagic zone of the lake during the years of pike stocking, possibly caused by behaviourial changes and the forcing of the 0+ planktivores into the pelagic zone...

  4. 78 FR 23572 - National Institute of Allergy and Infectious Diseases; Notice of Closed Meeting

    Science.gov (United States)

    2013-04-19

    ... applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Time: May 29, 2013, 8:00 a.m. to 6:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Washington... review and evaluate grant applications. Place: Hilton Washington/Rockville, 1750 Rockville Pike...

  5. Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

    Science.gov (United States)

    2014-01-01

    A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

  6. Assessment of oxidative stress and histopathology in juvenile northern pike (Esox lucius) inhabiting lakes downstream of a uranium mill

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, Jocelyn M. [Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, S7N 5B3 (Canada); Janz, David M., E-mail: david.janz@usask.ca [Toxicology Centre, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, S7N 5B3 (Canada); Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, S7N 5B4 (Canada)

    2009-05-17

    Lakes receiving effluent from the Key Lake uranium mill in northern Saskatchewan contain elevated trace metals, some of which are associated with increased reactive oxygen species (ROS) in cells and tissues causing oxidative stress. The potential for oxidative stress was assessed in juvenile (age 1+) northern pike (Esox lucius) collected from two exposure (high and low) and one reference lake near the Key Lake operation. The concentrations of total, reduced and oxidized glutathione and the ratio of oxidized to reduced glutathione in liver and kidney did not differ significantly among pike collected from exposure and reference lakes, with the exception of low exposure pike kidney that had significantly greater oxidized glutathione and ratio of oxidized to reduced glutathione. The concentrations of by-products of lipid peroxidation (malondialdehyde and 4-hydroxyalkenal) were significantly greater in kidney of pike collected from the reference lake compared to both exposure lakes. The activity of the antioxidant enzyme glutathione peroxidase in liver was greater in pike collected from the high exposure lake compared to the reference lake. Histopathological evaluations revealed greater pathology in reference lake pike as indicated by a greater number of pyknotic and fragmented nuclei and dilated tubules as well as a thickening of Bowman's capsule in kidney, and as a thickening of the primary filament epithelial padding in gills. In liver, hepatocyte morphology, including transsectional area and degree of vacuolation, differed among lakes without any clear signs of pathology. Trace metal analyses of muscle showed that eight elements (arsenic, cobalt, copper, iron, molybdenum, selenium, thallium, and uranium) were significantly elevated in pike collected from both exposure lakes compared to reference. These results provide only limited evidence of oxidative stress in exposure pike tissues and no evidence of histopathology despite indications that trace metals, most

  7. Assessment of oxidative stress and histopathology in juvenile northern pike (Esox lucius) inhabiting lakes downstream of a uranium mill

    International Nuclear Information System (INIS)

    Kelly, Jocelyn M.; Janz, David M.

    2009-01-01

    Lakes receiving effluent from the Key Lake uranium mill in northern Saskatchewan contain elevated trace metals, some of which are associated with increased reactive oxygen species (ROS) in cells and tissues causing oxidative stress. The potential for oxidative stress was assessed in juvenile (age 1+) northern pike (Esox lucius) collected from two exposure (high and low) and one reference lake near the Key Lake operation. The concentrations of total, reduced and oxidized glutathione and the ratio of oxidized to reduced glutathione in liver and kidney did not differ significantly among pike collected from exposure and reference lakes, with the exception of low exposure pike kidney that had significantly greater oxidized glutathione and ratio of oxidized to reduced glutathione. The concentrations of by-products of lipid peroxidation (malondialdehyde and 4-hydroxyalkenal) were significantly greater in kidney of pike collected from the reference lake compared to both exposure lakes. The activity of the antioxidant enzyme glutathione peroxidase in liver was greater in pike collected from the high exposure lake compared to the reference lake. Histopathological evaluations revealed greater pathology in reference lake pike as indicated by a greater number of pyknotic and fragmented nuclei and dilated tubules as well as a thickening of Bowman's capsule in kidney, and as a thickening of the primary filament epithelial padding in gills. In liver, hepatocyte morphology, including transsectional area and degree of vacuolation, differed among lakes without any clear signs of pathology. Trace metal analyses of muscle showed that eight elements (arsenic, cobalt, copper, iron, molybdenum, selenium, thallium, and uranium) were significantly elevated in pike collected from both exposure lakes compared to reference. These results provide only limited evidence of oxidative stress in exposure pike tissues and no evidence of histopathology despite indications that trace metals, most

  8. Suppression of invasive topmouth gudgeon Pseudorasbora parva by native pike Esox lucius in ponds

    OpenAIRE

    Lemmens, Pieter; Mergeay, Joachim; Vanhove, Tom; De Meester, Luc; Declerck, Steven A. J

    2015-01-01

    1. Asian topmouth gudgeon Pseudorasbora parva has been recognized as a highly invasive cyprinid fish species in Europe that can present risk to native fish communities. 2. The present study aimed to investigate whether a native piscivorous fish, pike Esox lucius, is able to reduce the establishment success and invasiveness of topmouth gudgeon Pseudorasbora parva in shallow ponds. We performed a large scale, replicated whole-pond experiment in which ponds were spontaneously colonized by to...

  9. Study of pike-perch (Sander lucioperca fishery from Razim Lake, Danube delta Romania

    Directory of Open Access Journals (Sweden)

    CERNIȘENCU Irina

    2018-05-01

    Full Text Available The Razim Lake is a great part of the Danube Delta Biosphere Reserve (DDBR, with a surface of 54,000 ha. Fish fauna from Razim lake include pike-perch (Sander lucioperca as one of the main top predators of fish community, however ecological significance indicates accessory species, recedent as dominance, sometimes been subrecedent species like in 2011 and 2012 sampling, but constant species regarding frequency in sampling. Otherwise, pike-perch is an important value DDBR fishery species with an average of 5% in total catch, range 2-10%, from what Razim lake contributes with average 71%, range 41-95% in the 1960-2015 period. Razim Lake has been in average 13%, range 1-40% from total Razim lake catch, in the same period of time. Since in RBDD has been fishing up to 2000 fisherman, in Razim lake activated up to 500 fishermen, however nowadays number of fishermen was regulated at lower range. Catch data series shows a continuous stock decline trend, considered to be a consequences of habitat degradation and over-exploitation. Fish stock estimation in last 15 years (2001-2016 support the hypothesis of over-exploitation. Based on length frequency structure of landings, the growth and exploitation parameters have been estimated as well as the average biomass and the maximum sustainable yields for the Razim lake pike-perch stock. Recommendation concerning fisheries management towards sustainable fishing of pike-perch stock, as increasing of cod-end seine mesh size and decreasing of fishing effort regulation are outlined.

  10. Convergent evolution of jaws between spinosaurid dinosaurs and pike conger eels

    Directory of Open Access Journals (Sweden)

    Romain Vullo

    2016-12-01

    Full Text Available Spinosaurs represent a group of peculiar theropod dinosaurs that have often been described as “crocodile-mimic”, predominantly fish-eating predators, and recently claimed to have been semi-aquatic animals. Here we report a suite of craniodental characters unexpectedly shared by spinosaurs and pike conger eels. Pike conger eels are predatory, mainly piscivorous bottom-dwelling anguilliform fishes that inhabit marine and brackish environments. These two groups of dinosaurs and fishes show a mediolaterally compressed, elongated rostrum, a terminal “rosette” bearing enlarged teeth in both upper and lower jaws, and a notch posterior to the premaxillary “rosette” characterized by the presence of reduced teeth. The morphological convergence observed in the jaws of these two distantly related groups of vertebrates may result from similar feeding behaviours. This typical jaw morphology likely represents an effective biomechanical adaptation for biting and grabbing elusive prey items in low-light aquatic environments. Associated with this specialized snout morphology, numerous integumentary mechanoreceptors involved in prey detection are present in both spinosaurs and pike congers. Our new observations provide an additional convincing argument regarding the decades-long and widely debated lifestyle of spinosaurs.

  11. Aquatic assessment of the Pike Hill Copper Mine Superfund site, Corinth, Vermont

    Science.gov (United States)

    Piatak, Nadine M.; Argue, Denise M.; Seal, Robert R.; Kiah, Richard G.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

    2013-01-01

    The Pike Hill Copper Mine Superfund site in Corinth, Orange County, Vermont, includes the Eureka, Union, and Smith mines along with areas of downstream aquatic ecosystem impairment. The site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004. The mines, which operated from about 1847 to 1919, contain underground workings, foundations from historical structures, several waste-rock piles, and some flotation tailings. The mine site is drained to the northeast by Pike Hill Brook, which includes several wetland areas, and to the southeast by an unnamed tributary that flows to the south and enters Cookville Brook. Both brooks eventually drain into the Waits River, which flows into the Connecticut River. The aquatic ecosystem at the site was assessed using a variety of approaches that investigated surface-water quality, sediment quality, and various ecological indicators of stream-ecosystem health. The degradation of surface-water quality is caused by elevated concentrations of copper, and to a lesser extent cadmium, with localized effects caused by aluminum, iron, and zinc. Copper concentrations in surface waters reached or exceeded the USEPA national recommended chronic water-quality criteria for the protection of aquatic life in all of the Pike Hill Brook sampling locations except for the location farthest downstream, in half of the locations sampled in the tributary to Cookville Brook, and in about half of the locations in one wetland area located in Pike Hill Brook. Most of these same locations also contained concentrations of cadmium that exceeded the chronic water-quality criteria. In contrast, surface waters at background sampling locations were below these criteria for copper and cadmium. Comparison of hardness-based and Biotic Ligand Model (BLM)-based criteria for copper yields similar results with respect to the extent or number of stations impaired for surface waters in the affected area. However, the BLM

  12. Shale fabric and velocity anisotropy : a study from Pikes Peak Waseca Oil Pool, Saskatchewan

    Energy Technology Data Exchange (ETDEWEB)

    Newrick, R.T.; Lawton, D.C. [Calgary Univ., AB (Canada). Dept. of Geology and Geophysics

    2004-07-01

    The stratigraphic sequence of the Pikes Peaks region in west-central Saskatchewan consists of a thick sequence of shale overlying interbedded sandstones, shale and coal from the Mannville Group. Hydrocarbons exist in the Waseca, Sparky and General Petroleum Formations in the Pikes Peak region. The primary objective of this study was to examine the layering of clay minerals in the shale and to find similarities or differences between samples that may be associated with velocity anisotropy. Anisotropy is of key concern in areas with thick shale sequences. Several processing algorithms include corrections for velocity anisotropy in order for seismic images to be well focused and laterally positioned. This study also estimated the Thomsen parameters of anisotropy through field studies. The relationship between the shale fabric and anisotropy was determined by photographic core samples from Pike Peak using a scanning electron microscope. Shale from two wells in the Waseca Oil Pool demonstrated highly variable fabric over a limited vertical extent. No layering of clay minerals was noted at the sub-centimetre scale. Transverse isotropy of the stratigraphy was therefore considered to be mainly intrinsic. 7 refs., 3 tabs., 9 figs.

  13. Potential of Environmental DNA to Evaluate Northern Pike (Esox lucius) Eradication Efforts: An Experimental Test and Case Study.

    Science.gov (United States)

    Dunker, Kristine J; Sepulveda, Adam J; Massengill, Robert L; Olsen, Jeffrey B; Russ, Ora L; Wenburg, John K; Antonovich, Anton

    2016-01-01

    Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA) sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius) following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets) to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of inquiry and sampling

  14. Potential of Environmental DNA to Evaluate Northern Pike (Esox lucius Eradication Efforts: An Experimental Test and Case Study.

    Directory of Open Access Journals (Sweden)

    Kristine J Dunker

    Full Text Available Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of

  15. Potential of environmental DNA to evaluate Northern pike (Esox lucius) eradication efforts: An experimental test and case study

    Science.gov (United States)

    Dunker, Kristine J.; Sepulveda, Adam; Massengill, Robert L.; Olsen, Jeffrey B.; Russ, Ora L.; Wenburg, John K.; Antonovich, Anton

    2016-01-01

    Determining the success of invasive species eradication efforts is challenging because populations at very low abundance are difficult to detect. Environmental DNA (eDNA) sampling has recently emerged as a powerful tool for detecting rare aquatic animals; however, detectable fragments of DNA can persist over time despite absence of the targeted taxa and can therefore complicate eDNA sampling after an eradication event. This complication is a large concern for fish eradication efforts in lakes since killed fish can sink to the bottom and slowly decay. DNA released from these carcasses may remain detectable for long periods. Here, we evaluated the efficacy of eDNA sampling to detect invasive Northern pike (Esox lucius) following piscicide eradication efforts in southcentral Alaskan lakes. We used field observations and experiments to test the sensitivity of our Northern pike eDNA assay and to evaluate the persistence of detectable DNA emitted from Northern pike carcasses. We then used eDNA sampling and traditional sampling (i.e., gillnets) to test for presence of Northern pike in four lakes subjected to a piscicide-treatment designed to eradicate this species. We found that our assay could detect an abundant, free-roaming population of Northern pike and could also detect low-densities of Northern pike held in cages. For these caged Northern pike, probability of detection decreased with distance from the cage. We then stocked three lakes with Northern pike carcasses and collected eDNA samples 7, 35 and 70 days post-stocking. We detected DNA at 7 and 35 days, but not at 70 days. Finally, we collected eDNA samples ~ 230 days after four lakes were subjected to piscicide-treatments and detected Northern pike DNA in 3 of 179 samples, with a single detection at each of three lakes, though we did not catch any Northern pike in gillnets. Taken together, we found that eDNA can help to inform eradication efforts if used in conjunction with multiple lines of inquiry and sampling

  16. Predicting the impact of a northern pike (Esox lucius) invasion on endangered June sucker (Chasmistes liorus) and sport fishes in Utah Lake, UT

    OpenAIRE

    Reynolds, Jamie

    2017-01-01

    Invasive species introductions are associated with negative economic and environmental impacts, including reductions in native species populations. Successful invasive species populations often grow rapidly and a new food web equilibrium is established. Invasive, predatory northern pike (Esox lucius; hereafter pike) were detected in 2010 in Utah Lake, UT, a highly-degraded ecosystem home to the endemic, endangered June sucker (Chasmistes liorus). Here we test whether pike predation could hind...

  17. Post-glacial dispersal patterns of Northern pike inferred from an 8800 year old pike (Esox cf. lucius) skull from interior Alaska

    Science.gov (United States)

    Wooller, Matthew J.; Gaglioti, Benjamin; Fulton, Tara L.; Lopez, Andres; Shapiro, Beth

    2015-07-01

    The biogeography of freshwater fish species during and after late-Pleistocene glaciations relate to how these species are genetically organized today, and the management of these often disjunct populations. Debate exists concerning the biogeography and routes of dispersal for Northern pike (Esox lucius) after the last glaciation. A hypothesis to account for the relatively low modern genetic diversity for E. lucius is post-glacial radiation from refugia, including lakes from within the un-glaciated portions of eastern Beringia. We report the remains of a Northern pike (E. cf. lucius) skull, including bones, teeth, bone collagen and ancient DNA. The remains were preserved at a depth of between 440 and 446 cm in a 670 cm long core of sediment from Quartz Lake, which initiated at ˜11,200 cal yr BP in interior Alaska. A calibrated accelerator mass spectrometer (AMS) radiocarbon age of the collagen extracted from the preserved bones indicated that the organism was dated to 8820 cal yr BP and is bracketed by AMS values from analyses of terrestrial plant macrofossils, avoiding any potential aquatic reservoir effect that could have influenced the radiocarbon age of the bones. Scanning electron microscope images of the specimen show the hinged tooth anatomy typically of E. lucius. Molar C:N (3.5, 1σ = 0.1) value of the collagen from the specimen indicated well-preserved collagen and its mean stable nitrogen isotope value is consistent with the known predatory feeding ecology of E. lucius. Ancient DNA in the bones showed that the specimen was identical to modern E. lucius. Our record of E. lucius from interior Alaska is consistent with a biogeographic scenario involving rapid dispersal of this species from glacial refugia in the northern hemisphere after the last glaciation.

  18. Year-class formation of upper St. Lawrence River northern pike

    Science.gov (United States)

    Smith, B.M.; Farrell, J.M.; Underwood, H.B.; Smith, S.J.

    2007-01-01

    Variables associated with year-class formation in upper St. Lawrence River northern pike Esox lucius were examined to explore population trends. A partial least-squares (PLS) regression model (PLS 1) was used to relate a year-class strength index (YCSI; 1974-1997) to explanatory variables associated with spawning and nursery areas (seasonal water level and temperature and their variability, number of ice days, and last day of ice presence). A second model (PLS 2) incorporated four additional ecological variables: potential predators (abundance of double-crested cormorants Phalacrocorax auritus and yellow perch Perca flavescens), female northern pike biomass (as a measure of stock-recruitment effects), and total phosphorus (productivity). Trends in adult northern pike catch revealed a decline (1981-2005), and year-class strength was positively related to catch per unit effort (CPUE; R2 = 0.58). The YCSI exceeded the 23-year mean in only 2 of the last 10 years. Cyclic patterns in the YCSI time series (along with strong year-classes every 4-6 years) were apparent, as was a dampening effect of amplitude beginning around 1990. The PLS 1 model explained over 50% of variation in both explanatory variables and the dependent variable, YCSI first-order moving-average residuals. Variables retained (N = 10; Wold's statistic ??? 0.8) included negative YCSI associations with high summer water levels, high variability in spring and fall water levels, and variability in fall water temperature. The YCSI exhibited positive associations with high spring, summer, and fall water temperature, variability in spring temperature, and high winter and spring water level. The PLS 2 model led to positive YCSI associations with phosphorus and yellow perch CPUE and a negative correlation with double-crested cormorant abundance. Environmental variables (water level and temperature) are hypothesized to regulate northern pike YCSI cycles, and dampening in YCSI magnitude may be related to a

  19. The effects of pulse pressure from seismic water gun technology on Northern Pike

    Science.gov (United States)

    Gross, Jackson A.; Irvine, Kathryn M.; Wilmoth, Siri K.; Wagner, Tristany L.; Shields, Patrick A; Fox, Jeffrey R.

    2013-01-01

    We examined the efficacy of sound pressure pulses generated from a water gun for controlling invasive Northern Pike Esox lucius. Pulse pressures from two sizes of water guns were evaluated for their effects on individual fish placed at a predetermined random distance. Fish mortality from a 5,620.8-cm3 water gun (peak pressure source level = 252 dB referenced to 1 μP at 1 m) was assessed every 24 h for 168 h, and damage (intact, hematoma, or rupture) to the gas bladder, kidney, and liver was recorded. The experiment was replicated with a 1,966.4-cm3 water gun (peak pressure source level = 244 dB referenced to 1 μP at 1 m), but fish were euthanized immediately. The peak sound pressure level (SPLpeak), peak-to-peak sound pressure level (SPLp-p), and frequency spectrums were recorded, and the cumulative sound exposure level (SELcum) was subsequently calculated. The SPLpeak, SPLp-p, and SELcum were correlated, and values varied significantly by treatment group for both guns. Mortality increased and organ damage was greater with decreasing distance to the water gun. Mortality (31%) by 168 h was only observed for Northern Pike exhibiting the highest degree of organ damage. Mortality at 72 h and 168 h postexposure was associated with increasing SELcum above 195 dB. The minimum SELcum calculated for gas bladder rupture was 199 dB recorded at 9 m from the 5,620.8-cm3 water gun and 194 dB recorded at 6 m from the 1,966.4-cm3water gun. Among Northern Pike that were exposed to the large water gun, 100% of fish exposed at 3 and 6 m had ruptured gas bladders, and 86% exposed at 9 m had ruptured gas bladders. Among fish that were exposed to pulse pressures from the smaller water gun, 78% exhibited gas bladder rupture. Results from these initial controlled experiments underscore the potential of water guns as a tool for controlling Northern Pike.

  20. INVESTIGATIONS ON TECHNOLOGICAL PARAMETERS IN INTENSIVE REARING OF PIKE-PERCH (STIZOSTEDION LUCIOPERCA

    Directory of Open Access Journals (Sweden)

    Tamás Molnár

    2000-06-01

    Full Text Available Market demands and competition force the production of high quality freshwater fish in European aquaculture. In Hungary pike-perch is the most „noble” and perhaps the most sensitive fish species. One of the constraints of the increasing its production in natural waters, reservoirs and ponds is the shortage in adequate sized alevins. The possible solution of this problem can be the elaboration of intensive rearing technics of pond prereared fry. The aims of the present work were to test the growing capacity, feed conversion and survival of pike-perch in intensive circumstances. Fish were kept in 130 l aquaria working in recirculation system at an average water temperature of 220.5 C. Two stocking densities were applied (18 and 36 fish/aquarium. Minced fish (test and live prey (control were offered twice a day till satiation in two replications. The experiment lasted 4 weeks. According to our results minced fish is suitable feed in the intensive rearing of pike-perch alevins. Daily food intake was only influenced significantly by different feeds (2.01g vs.4.53 g, test and control, respectively. Feeding and stocking density had significant effect (P=0.001 and 0.017 on the average weight gain (0.52 g and 1.40 g for minced fish and live feed, respectively, 1.02 g in lower and 0.90 g in higher density. Owning to the high variances treatment effect on feed conversion proved to be not significant. Average survival of the minced fish fed group was 62.2 % vs. 78.8 % of the live fish fed alevins. This difference was significant (P<0.01 in the first two weeks when almost all of the losses happened due to cannibalism and other unknown reasons. Based on our results a period of 10–14 days is needed for pre-reared pike-perch to change gradually their feeding from zooplankton to minced fish diet.

  1. Stocking impact and temporal stability of genetic composition in a brackish northern pike population ( Esox lucius L.), assessed using microsatellite DNA analysis of historical and contemporary samples

    DEFF Research Database (Denmark)

    Larsen, Peter Foged; Hansen, Michael Møller; Eg Nielsen, Einar

    2005-01-01

    During the last decade, brackish northern pike populations in Denmark have been subject to stocking programmes, using nonindigenous pike from freshwater lakes, in order to compensate for drastic population declines. The present study was designed to investigate the genetic impact of stocking fres...

  2. Development of new VNTR markers for pike and assessment of variability at di- and tetranucleotide repeat microsatellite loci

    DEFF Research Database (Denmark)

    Hansen, Michael Møller; Taggart, J.B.; Meldrup, Dorte

    1999-01-01

    Levels of variation at six VNTR (variable number of tandem repeats) loci, one minisatellite and five microsatellite loci, isolated from tri- and tetranucleotide enriched DNA libraries for northern pike were generally low in two Danish populations (1-4 alleles; expected heterozygosity 0-0.57), tho......Levels of variation at six VNTR (variable number of tandem repeats) loci, one minisatellite and five microsatellite loci, isolated from tri- and tetranucleotide enriched DNA libraries for northern pike were generally low in two Danish populations (1-4 alleles; expected heterozygosity 0...

  3. Changes of reproductive system of pike Esox Lucius L. in lake Drukshiai -the cooler of Ignalina NPP

    International Nuclear Information System (INIS)

    Lukshiene, D.

    1995-01-01

    On studying the reproductive system of pike in lake Drukshiai during 1992-1994 the same changes in fish gameto- and gonadogenesis as in other coolers were observed: -intensification of gametogenesis processes - earlier sexual maturity; -changes in gonadogenesis processes - a bias of all stages of sexual cycle as well as a change in duration; -disturbance of gametogenesis processes - total and partial degeneration of oocytes causing the disturbance of reproduction cycle what is reflected in the changes of some biological indices (gonadosomatic index and oocyte diameter). The above mentioned disturbances have a negative effect on normal functioning and reproduction of a pike population. (author). 8 refs., 2 figs

  4. Assessment of the water balance over France using regionalized Turc-Pike formula

    Science.gov (United States)

    Le Lay, Matthieu; Garçon, Rémy; Gailhard, Joël; Garavaglia, Federico

    2016-04-01

    With extensive use of hydrological models over a wide range of hydro-climatic contexts, bias in hydro-climatic data may lead to unreliable models and thus hydrological forecasts and projections. This issue is particularly pregnant when considering mountainous areas with great uncertainties on precipitations, or when considering complex unconservative catchments (e.g. karstic systems). The Turc-Pike water balance formula, analogous to the classical Budyko formula, is a simple and efficient mathematical formulation relating long-term average streamflow to long-term average precipitation and potential evaporation. In this study, we propose to apply this framework to assess and eventually adjust the water-balance before calibrating an operational hydrologic model (MORDOR model). Considering a large set of 350 french catchments, the Turc-Pike formula is regionalized based on ecohydrologic criterions to handle various hydro-climatic contexts. This interannual regional model is then applied to assess the water-balance over numerous catchments and various conditions, such as karstic, snow-driven or glaciarized and even anthropized catchments. Results show that it is possible to obtain pretty realistic corrections of meteorological inputs (precipitations, temperature or potential evaporation) or hydrologic surface (or runoff). These corrections can often be confirmed a posteriori by exogenous information. Positive impacts on hydrologic model's calibration are also demonstrated. This methodology is now operational for hydrologic applications at EDF (Electricité de France, French electric utility company), and therefore applied on hundreds of catchments.

  5. Length-weight relationship of northern pike, Esox lucius, from East Harbor, Ohio

    Science.gov (United States)

    Brown, Edward H.; Clark, Clarence F.

    1965-01-01

    The northern pike is one of Ohio's largest game fish but is well known to comparatively few anglers. Large numbers of the big fish spawn in the Ohio marshes adjacent to Lake Erie. Movements related to spawning reach a peak in late March or early April. Later the spawning population disperses and is seldom represented in catches by experimental gear or by anglers. The short period of availability was used to obtain life history information in March of 1951 through 1953. No comprehensive length-weight data for this species have previously been published from this area. East Harbor is a sandspit pond separated from Lake Erie by a large sand bar. Waters and fish populations of the harbor and lake can mix freely through a permanent connecting channel. The larger part of the 850 surface acres of the harbor is normally less than 8 feet deep. The male northern pike averaged 20.5 inches in length and ranged from 13.5 to 28.5 inches. The conspicuously larger females averaged 26.0 inches and ranged from 15.5 to 37.5 inches.

  6. 75 FR 10295 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-03-05

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5.... Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person: Gerald... evaluate contract proposals. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD...

  7. The interobserver reproducibility of thyroid cytopathology using Bethesda Reporting System: Analysis of 200 cases

    International Nuclear Information System (INIS)

    Ahmed, S.; Khan, M.A.; Kazi, F.

    2013-01-01

    Objective: To determine interobserver reproducibility of thyroid cytopathology in cases of thyroid fine needle aspirates. Methods: The retrospective, descriptive study, was conducted at the Foundation University Medical College, Islamabad, using cases related to period between 2009 and 2011. A total of 200 cases of fine-needle aspirations were retrieved from the archives. Three histopathologists independently categorised them into 6 groups according to Bethesda reporting system guidelines without looking at previous reports. Kappa statistics were used for analysis of the results on SPSS 17. Results: Of the 200 patients, 194 (97%) were females and 6 (3%) were males. The overall mean age of patients was 46+-20 years. Kappa value calculated for observer-1 and observer-2 was 0.735; for observer-1 and observer-3, 0.841; and for observer-2 and observer-3, 0.838, showing substantial interobserver agreement. Histopathological correlation was available, for 39(19.5%). Of these cases, 5(13%) were non-diagnostic, 20(51%) benign, 2(5%) atypia of undetermined significance/follicular lesion of undetermined significance, 6(15%) follicular neoplasm, 1(3%) suspicious for malignancy, and 5(13%) malignant. Conclusions: Good overall interobserver agreement was found, but discordance was seen when certain categories were analysed separately. (author)

  8. Multimodal assessment of visual attention using the Bethesda Eye & Attention Measure (BEAM).

    Science.gov (United States)

    Ettenhofer, Mark L; Hershaw, Jamie N; Barry, David M

    2016-01-01

    Computerized cognitive tests measuring manual response time (RT) and errors are often used in the assessment of visual attention. Evidence suggests that saccadic RT and errors may also provide valuable information about attention. This study was conducted to examine a novel approach to multimodal assessment of visual attention incorporating concurrent measurements of saccadic eye movements and manual responses. A computerized cognitive task, the Bethesda Eye & Attention Measure (BEAM) v.34, was designed to evaluate key attention networks through concurrent measurement of saccadic and manual RT and inhibition errors. Results from a community sample of n = 54 adults were analyzed to examine effects of BEAM attention cues on manual and saccadic RT and inhibition errors, internal reliability of BEAM metrics, relationships between parallel saccadic and manual metrics, and relationships of BEAM metrics to demographic characteristics. Effects of BEAM attention cues (alerting, orienting, interference, gap, and no-go signals) were consistent with previous literature examining key attention processes. However, corresponding saccadic and manual measurements were weakly related to each other, and only manual measurements were related to estimated verbal intelligence or years of education. This study provides preliminary support for the feasibility of multimodal assessment of visual attention using the BEAM. Results suggest that BEAM saccadic and manual metrics provide divergent measurements. Additional research will be needed to obtain comprehensive normative data, to cross-validate BEAM measurements with other indicators of neural and cognitive function, and to evaluate the utility of these metrics within clinical populations of interest.

  9. Review of the Bethesda System for Reporting Thyroid Cytopathology: a local study in Bohol Island, Philippines.

    Science.gov (United States)

    Salillas, Annette L; Sun, Faye Candice S; Almocera, Emelisa G

    2015-01-01

    The aim of this study was to evaluate the adaptability and reproducibility of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) in a local setting and to determine the risk of malignancy for each category. A retrospective cross-sectional study of 80 thyroid fine-needle aspiration cytology cases using the BSRTC with corresponding histopathology was done between September 2009 and December 2012. Agreement scores were calculated using kappa statistics. Consensus among two readers was attained for 73 cases (91.25%). No disagreement was noted for the malignant cases. The strength of agreement was very good, with a kappa statistic of 0.90. The risk of malignancy observed histologically was as follows: benign 3%, atypia of undetermined significance (AUS) 50%, suspicious for follicular/Hürthle cell neoplasm 50%, suspicious for malignancy 78%, and malignant 100%. In this study, there is an outstanding reproducibility for the classification scheme. The application of the BSRTC as the standardized reporting is readily adaptable and therefore its application in larger medical centers is highly recommended. Our findings of a higher risk of malignancy seen in AUS (50%) and malignant (100%) categories in those who underwent surgical resection corroborated other published studies. Conveying this risk to clinical colleagues is important and will facilitate optimal patient care. © 2015 S. Karger AG, Basel.

  10. Predicted high-water elevations for selected flood events at the Albert Pike Recreation Area, Ouachita National Forest

    Science.gov (United States)

    D.A. Marion

    2012-01-01

    The hydraulic characteristics are determined for the June 11, 2010, flood on the Little Missouri River at the Albert Pike Recreation Area in Arkansas. These characteristics are then used to predict the high-water elevations for the 10-, 25-, 50-, and 100-year flood events in the Loop B, C, and D Campgrounds of the recreation area. The peak discharge and related...

  11. Slaughter yield and fatty acid profiles of fillets of pike (Esox lucius L. caught before and after spawning

    Directory of Open Access Journals (Sweden)

    Zakęś Zdzisław

    2015-12-01

    Full Text Available The aim of the study was to determine the impact pike fishing season (before spawning in fall (group A and after spawning in spring (group B had on the slaughter yield and fillet fatty acid profile. The slaughter yield of fillets with skin and skinned fillets from the group B fish was significantly lower (by approximately 7.5% of body weight. The fatty acid profile of the fish meat from the groups examined differed significantly. The fillets of pike caught before spawning were dominated by unsaturated fatty acids (UFA, while those from fish caught after spawning had mainly saturated fatty acids (SFA. The share of polyunsaturated fatty acids (PUFA in the fillets of fish that had spawned was sixfold lower, and the n-3 PUFA differences were nearly ninefold. The content of eicosapentaenoic (EPA and docosahexaenoic (DHA fatty acids in fillets of fish that had spawned was ninefold lower than in those that had not yet done so. Consequently, the ratio of n-3 PUFA/n-6 PUFA in pike from group A was over three times higher than that in the fish that had spawned (2.61 vs 0.82. Fillets from pike that have spawned are a significantly poorer source of valuable fatty acids for consumers.

  12. Seasonal and diel effects on the activity of northern pike studied by high-resolution positional telemetry

    DEFF Research Database (Denmark)

    Baktoft, Henrik; Aarestrup, Kim; Berg, Søren

    2012-01-01

    , a detailed understanding of the behaviour of this species during winter is important. We continuously monitored the activity of adult northern pike (Esox lucius) in a small temperate lake from late summer to winter for two consecutive years using an automatic acoustic positional telemetry system. Four...

  13. DYNAMICS OF PIKE (ESOX LUCIUS LINNAEUS, 1758 AGE STRUCTURE IN THE DNIEPER LOWER REACHES IN CONNECTION WITH FISHING

    Directory of Open Access Journals (Sweden)

    K. Geina

    2015-03-01

    Full Text Available Purpose. To analyze the dynamics of pike (Esox luceus Linnaeus, 1758 age structure of the Dnieper lower reaches in conditions of the modification of fishing pressure. Methodology. An analysis of fishing situation has been performed based on data of official fishery statistics. Fish sampling was done at control-observation posts of the Institute of Fisheries of the NAAS of Ukraine and directly in the fishery. Juvenile fish yield was determined using a complex of fry fishing gears using a stationary net-station. Field and cameral processing of the material was performed using generally accepted methods. Findings. A retrospective analysis of the situation in the Dnieper-Bug lower reach system clearly indicates on the presence of continuous tendency of catch decline of representative of native fish fauna – pike. With relatively uniform indices of the “yield” of its juveniles before Dnieper flow impoundment and in conditions of present time, its commercial catches significantly dropped. The dynamics of pike current age structure indicates on an increase of relative density of age groups, which form the recruitment of the commercial portion of the population (1-1+ and a decrease of importance of the component of the right side of age series. A discrepancy between the observed changes of the age group and commercial harvest quantities indicates on increased human pressure on this species. Originality. For the first, we analyzed the dynamics of fish juvenile “yield” and age structure of pike commercial stock of the Dnieper lower reaches in the river flow transformation process. Practical value. A decrease of the ichthyomass of piscivorous fishes in the Dnieper lower reaches results in changes of fish populations of littoral biotopes towards the prevalence of the dominance of coarse species that lead to a deterioration of forage availability for a number of valuable commercial species. An increase of the number of pike can regulate the strain

  14. The revised Bethesda guidelines: extent of utilization in a university hospital medical center with a cancer genetics program

    Directory of Open Access Journals (Sweden)

    Mukherjee Aparna

    2010-11-01

    Full Text Available Abstract Background In 1996, the National Cancer Institute hosted an international workshop to develop criteria to identify patients with colorectal cancer who should be offered microsatellite instability (MSI testing due to an increased risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC. These criteria were further modified in 2004 and became known as the revised Bethesda Guidelines. Our study aimed to retrospectively evaluate the percentage of patients diagnosed with HNPCC tumors in 2004 who met revised Bethesda criteria for MSI testing, who were referred for genetic counseling within our institution. Methods All HNPCC tumors diagnosed in 2004 were identified by accessing CoPath, an internal database. Both the Tumor Registry and patients' electronic medical records were accessed to collect all relevant family history information. The list of patients who met at least one of the revised Bethesda criteria, who were candidates for MSI testing, was then cross-referenced with the database of patients referred for genetic counseling within our institution. Results A total of 380 HNPCC-associated tumors were diagnosed at our institution during 2004 of which 41 (10.7% met at least one of the revised Bethesda criteria. Eight (19.5% of these patients were referred for cancer genetic counseling of which 2 (25% were seen by a genetics professional. Ultimately, only 4.9% of patients eligible for MSI testing in 2004 were seen for genetic counseling. Conclusion This retrospective study identified a number of barriers, both internal and external, which hindered the identification of individuals with HNPCC, thus limiting the ability to appropriately manage these high risk families.

  15. Isolation and characterization of gonadotropin isohormones from the pituitary gland of pike eel (Muraenesox cinereus)

    International Nuclear Information System (INIS)

    Huang, F.-L.; Huang, C.-J.; Lin, S.-H.; Lo, T.-B.; Papkoff, H.

    1981-01-01

    Pike eel gonadotropins were isolated from pituitary glands by 40% alcohol-6% ammonium acetate, pH 5.1 extraction and were purified by DEAE-cellulose chromatography and electrophoresis into four electrophoretically homogeneous forms. These four isohormones were biologically identified as gonadotropins by the stimulation of 32 P-uptake in 1-day-old chick testes, by the induction of ovulation in catfish, and by the in vitro production of testosterone from isolated rat Leydig cells and of androgen from carp testes. The amino acid composition of the isohormones were similar to other known piscine gonadotropins (carp and salmon) and were composed of two non-identical subunits with Tyr and Ser as N-terminal amino acid residues. The molecular weights of two subunits were 15000 and 10500, respectively, as estimated by SDS-gel disc electrophoresis. (author)

  16. The role of clinical pathway on the outcomes of ischemic stroke patients at Bethesda Hospital Yogyakarta

    Directory of Open Access Journals (Sweden)

    Francisca Diana Alexandra, Iwan Dwiprahasto, Rizaldy Pinzon

    2014-04-01

    Full Text Available Stroke becomes world health problem all over the world because it is the causal factor of high mortality and disability. Good and well-organized process of healthcare service will improve the outcome of the patients with stroke. Clinical pathway may be used as clear standard to help reduce unnecessary variations of medical treatment and measure. The study aimed at finding out the correlation between the use of clinical pathway and the outcome of the patients with ischemic stroke in Bethesda Hospital Yogyakarta. It was an observational and analytic study with cohort restorative study design. The author compared the outcomes of acute ischemic stroke between the group with clinical pathway and the group without the clinical pathway. Data was collected using consecutive sampling from the electronic registry and medical record data of the patients from January 1st, 2011 to December 31st, 2011. It was conducted to 124 patients with ischemic stroke assigned to two groups (the first groups of 62 patients with clinical pathway and the second groups of 62 patients without clinical pathway. The basic characteristics of the two groups were the same. The results of the analysis showed that there was a significant decrease in the incidence of complication and a significant increase in the use of antiplatelete drugs, antidiabetic drugs and statin as secondary preventive measure of the recurrent stroke. There was not any significant difference in the duration of the hospitalized healthcare, the financing and the mortality between the two observation groups. The study indicated that the use of the clinical pathway in the stroke treatment improved the outcome of the patients with stroke. It was necessary to conduct further study to evaluate the effectiveness of the clinical pathway in improving the outcome of the patients with bigger number of the subjects and the longer period of time.

  17. [Atypical urothelial cells (AUC): A Bethesda-derived wording applicable to urinary cytopathology].

    Science.gov (United States)

    Piaton, Eric; Advenier, Anne-Sophie; Benaïm, Gilles; Petrucci, Myriam Decaussin; Lechevallier, Florence Mege; Ruffion, Alain

    2011-02-01

    To investigate (1) whether sparse nuclear atypias involving deep urothelial cells have a diagnostic or prognostic value in urinary cytology, and (2) whether the terms atypical urothelial cells "of undetermined significance" (AUC-US) or "cannot exclude high grade" (AUC-H) might be used to standardize urinary cytology reports. Atypical urothelial cells (AUC) were defined as deep cells with nuclear abnormalities (increased N/C ratio, eccentric nucleus, hyperchromatism and/or irregular shape) in small number not allowing their categorization as malignant, high grade. We studied 435 urinary samples from 126 patients with AUC at any step of their clinical history, followed up over a 10-year period (1999-2009). Every case was compared with histopathology within 6 months and to long term follow-up including cystoscopy and histopathology combined. A total of 183 AUC was recorded. AUC were associated with negative, benign or low grade histological results in 36 of 106 cases (33.9 %) within 6 months, but a high grade was simultaneously documented in 70 cases (66 %). AUC preceded high-grade lesions in 66 cases (36.1 % of all AUC) in a mean interval of 10.5±12.0 months. Overall, AUC were associated with or predictive of high-grade lesions in 135 cases (73.8 %). AUC have a diagnostic and prognostic value. Applying the terms AUC-US and AUC-H to urinary cytopathology reports would allow, as for the Bethesda system for cervical or vaginal cytologic diagnoses, better appreciation of the risk of progression to high grade tumours in cases with atypias. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  18. Uptake and transport of manganese in primary and secondary olfactory neurones in pike.

    Science.gov (United States)

    Tjälve, H; Mejàre, C; Borg-Neczak, K

    1995-07-01

    gamma-spectrometry and autoradiography were used to examine the axoplasmic flow of manganese in the olfactory nerves and to study the uptake of the metal in the brain after application of 54Mn2+ in the olfactory chambers of pikes. The results show that the 54Mn2+ is taken up in the olfactory receptor cells and is transported at a constant rate along the primary olfactory neurones into the brain. The maximal velocity for the transported 54Mn2+ was 2.90 +/- 0.21 mm/hr (mean +/- S.E.) at 10 degrees, which was the temperature used in the experiments. The 54Mn2+ accumulated in the entire olfactory bulbs, although most marked in central and caudal parts. The metal was also seen to migrate into large areas of the telencephalon, apparently mainly via the secondary olfactory axons present in the medial olfactory tract. A transfer along fibres of the medial olfactory tract probably also explains the labelling which was seen in the diencephalon down to the hypothalamus. The results also showed that there is a pathway connecting the two olfactory bulbs of the pike and that this can carry the metal. Our data further showed a marked accumulation of 54Mn2+ in the meningeal epithelium and in the contents of the meningeal sacs surrounding the olfactory bulbs. It appears from our study that manganese has the ability to pass the synaptic junctions between the primary and the secondary olfactory neurones in the olfactory bulbs and to migrate along secondary olfactory pathways into the telencephalon and the diencephalon.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. Improving bethesda reporting in thyroid cytology: A team effort goes a long way and still miles to go…

    Directory of Open Access Journals (Sweden)

    Subramanian Kannan

    2017-01-01

    Full Text Available Context: Fine-needle aspiration cytology is the first step in evaluation of thyroid nodules. Although the Bethesda classification for reporting thyroid cytology has been purported that this uniformity in reporting cytology thereby facilitating clinical decision-making, there are also studies indicating that the reporting percentage and the rates of malignancy in each category vary considerably from center to center making the clinical decision more difficult. Aim and Materials and Methods: We looked at our retrospective cytology and histopathology data of thyroid nodules operated between 2012 and 2014 and then prospectively collected data during 2015–2016. In the prospective arm, for every thyroid nodule that was sampled, there was a discussion between the endocrinologist and the cytopathologist on the risk of thyroid cancer (based on the patient's history, examination findings, sonographic pattern, and the cytological appearance. Results: We noted that there was considerable improvement in reporting standards with the rates of nondiagnostic cytology dropping from 11% to 5%, an increased reporting of Bethesda Category 2 and 6 which are the definitive strata of benign and malignant nodules (38% to 41% in Category 2 and 7% to 11% in Category 6 with a high specificity (100%. There was a decline in numbers of Category 4 and 5 (13% to 9% in Category 4 and 12% to 3% in Category 5. The reporting prevalence of Category 3 increased from 19% to 27%. Conclusions: We conclude that a team approach between the clinician who performs the ultrasound and the reporting cytopathologist improves Bethesda reporting, its predictive value, and thus potentially avoiding unnecessary thyroidectomies in benign thyroid nodules and hemithyroidectomies in thyroid cancers.

  20. 75 FR 3741 - National Center for Research Resources; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-22

    ... concept review of proposed grant applications. Place: Hilton Rockville, 1750 Rockville Pike, Rockville, MD.... Agenda: To review and evaluate grant applications. Place: National Institutes of Health, 6701 Rockledge.... to 5 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Rockville, 1750 Rockville...

  1. Performance of Hitchens-Pike-Todd-Hewitt medium for group B streptococcus screening in pregnant women.

    Directory of Open Access Journals (Sweden)

    Simone Cristina Castanho Sabaini de Melo

    Full Text Available Group B streptococcus (GBS, which commonly colonizes the female genital tract and rectum, can cause infections in newborns with varying severity, possibly leading to death. The aim of the present study was to evaluate Hitchens-Pike-Todd-Hewitt (HPTH medium performance for GBS screening in pregnant women. A descriptive analytical cross-sectional study was performed with 556 pregnant women, of which 496 were at 35-37 weeks of gestation and 60 were at ≥ 38 weeks of gestation. The study was conducted from September 2011 to March 2014 in northern Paraná, Brazil. Vaginal and anorectal clinical specimens from each pregnant woman were plated on sheep blood agar (SBA and seeded on HPTH medium and Todd-Hewitt enrichment broth. Of the 496 pregnant women at 35-37 weeks of gestation, 141 (28.4% were positive for GBS, based on the combination of the three culture media and clinical specimens. The GBS colonization rates that were detected by each medium were 22.2% for HPTH medium, 21.2% for SBA, and 13.1% for Todd-Hewitt enrichment broth. Of the 60 pregnant women at ≥ 38 weeks of gestation, seven (11.7% were positive for GBS. These results demonstrate that HPTH medium and SBA were more sensitive than Todd-Hewitt enrichment broth for GBS screening in pregnant women and good GBS recovery in culture, indicating that the two media should be used together for vaginal and anorectal specimens.

  2. New Zealand mining legislation and recommendations for change following the Pike River disaster

    International Nuclear Information System (INIS)

    King, Tony

    2012-01-01

    There is good evidence that existing health and safety legislation in New Zealand (NZ) has produced a marked and sustained improvement in occupational health and in high-frequency low-consequence accidents.The same cannot be said for high-consequence low-frequency events. Changes to the regulatory framework should focus on these high- consequence low-frequency events although not to the detriment of low- consequence event safety. The (NZ) underground coal mining industry is characterised by a very small number of operating mines that are distinctly different from each other. This is also true of proposed mines, where there is even more variety in the type of firms proposing to operate these mines. The risks that each individual mine faces are varied and risks that predominate in one operation (for example methane or spontaneous combustion) may be entirely absent at another nearby operation. Research strongly suggests that the best regulatory approach for underground coal mines in NZ is process-based standards, supported by performance standards to identify issues and set appropriate performance outcomes. A well-resourced locally based inspectorate comprising knowledgeable and experienced inspectors with NZ mining experience is required, supported by access to overseas expertise. The Health and Safety in Employment Act 1992 should remain the governing legislation for NZ coal mining. The existing mining-specific regulations should be replaced for underground coal mining with a new set of regulations. These new regulations should draw heavily on the Queensland regulations with the best aspects of New South Wales and elsewhere also included. The internationalisation of management, advisors and workers supports an approach based on good overseas practice, rather than a highly- individualised, uniquely NZ solution. Learnings and recommendations from the Pike River Royal Commission should be incorporated into performance standards and outcomes in the new regulations.

  3. From regionally predictable to locally complex population structure in a freshwater top predator: River systems are not always the unit of connectivity in Northern Pike Esox lucius

    DEFF Research Database (Denmark)

    Bekkevold, Dorte; Jacobsen, Lene; Hansen, Jakob Hemmer

    2015-01-01

    Contemporary genetic diversity is the product of both historical and contemporary forces, such as climatic and geological processes affecting range distribution and continuously moulded by evolutionary forces selection, gene flow and genetic drift. Predatory freshwater fishes, such as Northern Pike...... structure from local to regional scales is relatively poorly described, in spite of its significance to developing conservation measures. We analysed microsatellite variation in a total of 1185 North European pike from 46 samples collected across both local and regional scales, as well as over time......, to address two overarching questions: Is pike population structure associated with local and/or regional connectivity patterns, and which factors likely have the main influence on the contemporary distribution of genetic diversity? To answer this, we combined estimators of population diversity and structure...

  4. Dispersal, growth and diet of stocked and wild northern pike fry in a shallow natural lake, with implications for management of stocking programs

    DEFF Research Database (Denmark)

    Skov, Christian; Koed, Anders; Baastrup-Spohr, Lars

    2011-01-01

    season. Stomach analyses revealed that the stocked pike ingested less diverse prey items and had higher fractions of empty stomachs throughout the study period. Overall, the fraction of stocked pike in samples rapidly declined over the season, which may have been caused by differential survival...... low fitness of stocked individuals in competition with wild conspecifics: (1) genetic-based local maladaptation among the stocked fish and (2) carryover effects from the hatchery. The latter may be less likely because the fry stocked were the offspring of wild fish and only spent a few weeks...

  5. Time for Decisions: Visualizing the Future. Proceedings of the Annual NEAIR Conference (39th, Bethesda, Maryland, November 3-6, 2012)

    Science.gov (United States)

    Carson, Cristi, Ed.

    2012-01-01

    The NEAIR (North East Association for Institutional Research) 2012 Conference Proceedings is a compilation of papers presented at the Bethesda, Maryland conference. Papers in this document include: (1) Can a Marketing Campaign Increase Response Rates to Online Course Evaluations? (Kimberly Puhala); (2) Developing Community College Peer…

  6. Visibility conditions and diel period affect small-scale spatio-temporal behaviour of pike Esox lucius in the absence of prey and conspecifics

    DEFF Research Database (Denmark)

    Nilsson, P A; Baktoft, Henrik; Boel, Mikkel

    2012-01-01

    Pike Esox lucius in the absence of prey and conspecifics were shown to have the highest habitat-change activity during dusk and to decrease preference for complex habitats in turbid water. As the behaviours indicate routine responses in the absence of behavioural interactions, E. lucius spatio...

  7. 77 FR 17102 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-03-23

    ...' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. ADDITIONAL ITEMS TO BE...-11-13 (Apr. 26, 2011), Docket No. 50- 346-LR (Tentative). This meeting will be webcast live at the...

  8. 78 FR 32476 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Digital I&C...

    Science.gov (United States)

    2013-05-30

    ..., June 4, 2013--1:00 p.m. Until 5:00 p.m. The Subcommittee will review and discuss all cyber security... Flint North building, 11555 Rockville Pike, Rockville, MD. After registering with security, please...

  9. 77 FR 29678 - National Institute of Mental Health; Notice of Closed Meeting

    Science.gov (United States)

    2012-05-18

    ... evaluate personal qualifications and performance, and competence of individual investigators. Place: Hilton... Functional Neuroanatomy, and the Laboratory of Molecular Biology. Place: Hilton Washington/Rockville, 1750... Scientists. Place: Hilton Washington/Rockville, 1750 Rockville Pike, Rockville, MD 20852. Time: June 5, 2012...

  10. [Implementation of cytology images classification--the Bethesda 2001 System--in a group of screened women from Podlaskie region--effect evaluation].

    Science.gov (United States)

    Zbroch, Tomasz; Knapp, Paweł Grzegorz; Knapp, Piotr Andrzej

    2007-09-01

    Increasing knowledge concerning carcinogenesis within cervical epithelium has forced us to make continues modifications of cytology classification of the cervical smears. Eventually, new descriptions of the submicroscopic cytomorphological abnormalities have enabled the implementation of Bethesda System which was meant to take place of the former Papanicolaou classification although temporarily both are sometimes used simultaneously. The aim of this study was to compare results of these two classification systems in the aspect of diagnostic accuracy verified by further tests of the diagnostic algorithm for the cervical lesion evaluation. The study was conducted in the group of women selected from general population, the criteria being the place of living and cervical cancer age risk group, in the consecutive periods of mass screening in Podlaski region. The performed diagnostic tests have been based on the commonly used algorithm, as well as identical laboratory and methodological conditions. Performed assessment revealed comparable diagnostic accuracy of both analyzing classifications, verified by histological examination, although with marked higher specificity for dysplastic lesions with decreased number of HSIL results and increased diagnosis of LSILs. Higher number of performed colposcopies and biopsies were an additional consequence of TBS classification. Results based on Bethesda System made it possible to find the sources and reasons of abnormalities with much greater precision, which enabled causing agent treatment. Two evaluated cytology classification systems, although not much different, depicted higher potential of TBS and better, more effective communication between cytology laboratory and gynecologist, making reasonable implementation of The Bethesda System in the daily cytology screening work.

  11. Reproducibility of “The bethesda system for reporting thyroid cytopathology:” A retrospective analysis of 107 patients

    Directory of Open Access Journals (Sweden)

    Pragati Awasthi

    2018-01-01

    Full Text Available Objectives: Fine-needle aspiration cytology (FNAC has emerged as an indispensable tool to discriminate thyroid lesions into benign or malignant for appropriate management. The need for simplicity of communication and standardization of terminology for thyroid FNAC reporting led to introduction of “The Bethesda system for reporting Thyroid Cytopathology” (TBSRTC in a conference held at the National Cancer Institute in 2007. This study aims at establishing the reproducibility of TBSRTC for diagnosing thyroid lesions. Materials and Methods: The present study comprised thyroid FNAC from 107 patients retrospectively over a period of 1.5 year (June 2013 to December 2014, which were reviewed by two trained cytopathologists and re-categorized according to TBSRTC. The interobserver variation and reproducibility of the reporting system was statistically assessed using Cohen's kappa. Results: The cytopathologists were in agreement in 98 out of 107 cases (91.5%. Maximum concordance was noted in benign category (91 of 96 cases; 92.85%, followed by 2 cases each in nondiagnostic/unsatisfactory (ND/US and follicular neoplasm/suspicious for follicular neoplasm (FN/SFN category (2.04% each and 1 case each in atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS, suspicious for malignancy (SUS, and malignant category (1.02% each. The highest diagnostic disagreement was noted among ND/US and benign and benign and FN/SFN categories. Conclusion: The utilization of TBSRTC for reporting thyroid cytology should be promoted in our country because it provides a homogeneous, standardized, and unanimous terminology for cytological diagnosis of thyroid lesions. The present study could substantiate the diagnostic reproducibility of this system.

  12. An Assessment of Weight-Length Relationships for Muskellunge,Northern Pike, and Chain Pickerel In Carlander's Handbook of Freshwater Fishery Biology

    OpenAIRE

    Daviscourt, Joshua; Huertas, Joshua; Courtney, Michael

    2011-01-01

    Carlander's Handbook of Freshwater Fishery Biology (1969) contains life history data from many species of freshwater fish found in North America. It has been cited over 1200 times and used to produce standard-weight curves for some species. Recent work (Cole-Fletcher et al. 2011) suggests Carlander (1969) contains numerous errors in listed weight-length equations. This paper assesses the weight-length relationships listed in Carlander for muskellunge, northern pike, and chain pickerel by comp...

  13. Risk of invasion predicted with support vector machines: A case study on northern pike (Esox Lucius, L.) and bleak (Alburnus alburnus, L.)

    OpenAIRE

    Muñoz Mas, Rafael; Vezza, Paolo; Alcaraz-Hernández, Juan Diego; Martinez-Capel, Francisco

    2016-01-01

    The impacts of invasive species are recognised as a major threat to global freshwater biodiversity. The risk of invasion (probability of presence) of two avowed invasive species, the northern pike (Esox Lucius, L.) and bleak (Alburnus alburnus, L.), was evaluated in the upper part of the Cabriel River (eastern Iberian Peninsula). Habitat suitability models for these invasive species were developed with Support Vector Machines (SVMs), which were trained with data collected downstream the Contr...

  14. 2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia.

    Science.gov (United States)

    Wood, Brent L; Arroz, Maria; Barnett, David; DiGiuseppe, Joseph; Greig, Bruce; Kussick, Steven J; Oldaker, Teri; Shenkin, Mark; Stone, Elizabeth; Wallace, Paul

    2007-01-01

    Immunophenotyping by flow cytometry has become standard practice in the evaluation and monitoring of patients with hematopoietic neoplasia. However, despite its widespread use, considerable variability continues to exist in the reagents used for evaluation and the format in which results are reported. As part of the 2006 Bethesda Consensus conference, a committee was formed to attempt to define a consensus set of reagents suitable for general use in the diagnosis and monitoring of hematopoietic neoplasms. The committee included laboratory professionals from private, public, and university hospitals as well as large reference laboratories that routinely operate clinical flow cytometry laboratories with an emphasis on lymphoma and leukemia immunophenotyping. A survey of participants successfully identified the cell lineage(s) to be evaluated for each of a variety of specific medical indications and defined a set of consensus reagents suitable for the initial evaluation of each cell lineage. Elements to be included in the reporting of clinical flow cytometric results for leukemia and lymphoma evaluation were also refined and are comprehensively listed. The 2006 Bethesda Consensus conference represents the first successful attempt to define a set of consensus reagents suitable for the initial evaluation of hematopoietic neoplasia. Copyright 2007 Clinical Cytometry Society.

  15. 78 FR 18375 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2013-03-26

    ... Pike, Rockville, Maryland. Thursday, April 11, 2013, Conference Room T2-B1, 11545 Rockville Pike..., ``Westinghouse BWR ECCS Evaluation Model: Supplement 5--Application to the ABWR,'' Revision 0 (Open/Closed)--The...-17116-P, ``Westinghouse BWR Emergency Core Coolant System (ECCS) Evaluation Model: Supplement 5,'' and...

  16. 78 FR 3473 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2013-01-16

    ... Pike, Rockville, Maryland. Thursday, February 7, 2013, Conference Room T2-B1, 11545 Rockville Pike... Evaluation Report Associated with the License Renewal Application for the Limerick Generating Station, Units... of the NRC staff and Exelon Corporation regarding the final safety evaluation report associated with...

  17. 78 FR 70078 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2013-11-22

    ... Pike, Rockville, Maryland. Wednesday, December 4, 2013, Conference Room T2-B1, 11545 Rockville Pike....: Selected Chapters of the Safety Evaluation Report (SER) With Open Items Associated With the Calvert Cliffs...)(4).] 10:45 a.m.-12:45 p.m.: Topical Report and Selected Chapters of the Safety Evaluation Reports...

  18. 77 FR 58420 - Advisory Committee On Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2012-09-20

    ... Pike, Rockville, Maryland. Thursday, October 4, 2012, Conference Room T2-B1, 11545 Rockville Pike....: Safety Evaluation Report (SER) Associated with WCAP-16793-NP, Revision 2, ``Evaluation of Long-Term..., ``Evaluation of JNES Equipment Fragility Tests for Use in Seismic Probabilistic Risk Assessments for U.S...

  19. 78 FR 65009 - Advisory Committee On Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2013-10-30

    ... Pike, Rockville, Maryland. Thursday November 7, 2013, Conference Room T2-B1, 11545 Rockville Pike... will make opening remarks regarding the conduct of the meeting. 8:35 a.m.-10:30 a.m.: Safety Evaluation... safety evaluation associated with the Watts Bar, Unit 2, operating license. 10:45 a.m.-12:45 p.m.: Near...

  20. 77 FR 51580 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Science.gov (United States)

    2012-08-24

    ... Pike, Rockville, Maryland. Thursday, September 6, 2012, Conference Room T2-B1, 11545 Rockville Pike... p.m.-3:15 p.m.: Selected Chapters of the Safety Evaluation Reports (SERs) with Open Items Associated... and Peach Bottom,'' and (2) NUREG/CR-7040, ``Evaluation of JNES Equipment Fragility Tests for Use in...

  1. Two-dimensional simulation of the June 11, 2010, flood of the Little Missouri River at Albert Pike Recreational Area, Ouachita National Forest, Arkansas

    Science.gov (United States)

    Wagner, Daniel M.

    2013-01-01

    In the early morning hours of June 11, 2010, substantial flooding occurred at Albert Pike Recreation Area in the Ouachita National Forest of west-central Arkansas, killing 20 campers. The U.S. Forest Service needed information concerning the extent and depth of flood inundation, the water velocity, and flow paths throughout Albert Pike Recreation Area for the flood and for streamflows corresponding to annual exceedence probabilities of 1 and 2 percent. The two-dimensional flow model Fst2DH, part of the Federal Highway Administration’s Finite Element Surface-water Modeling System, and the graphical user interface Surface-water Modeling System (SMS) were used to perform a steady-state simulation of the flood in a 1.5-mile reach of the Little Missouri River at Albert Pike Recreation Area. Peak streamflows of the Little Missouri River and tributary Brier Creek served as inputs to the simulation, which was calibrated to the surveyed elevations of high-water marks left by the flood and then used to predict flooding that would result from streamflows corresponding to annual exceedence probabilities of 1 and 2 percent. The simulated extent of the June 11, 2010, flood matched the observed extent of flooding at Albert Pike Recreation Area. The mean depth of inundation in the camp areas was 8.5 feet in Area D, 7.4 feet in Area C, 3.8 feet in Areas A, B, and the Day Use Area, and 12.5 feet in Lowry’s Camp Albert Pike. The mean water velocity was 7.2 feet per second in Area D, 7.6 feet per second in Area C, 7.2 feet per second in Areas A, B, and the Day Use Area, and 7.6 feet per second in Lowry’s Camp Albert Pike. A sensitivity analysis indicated that varying the streamflow of the Little Missouri River had the greatest effect on simulated water-surface elevation, while varying the streamflow of tributary Brier Creek had the least effect. Simulated water-surface elevations were lower than those modeled by the U.S. Forest Service using the standard-step method, but the

  2. 78 FR 60297 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-10-01

    ..., Rockville, MD 20852. Contact Person: Leonid V. Tsap, Ph.D., Scientific Review Officer, Center for Scientific...: Residence Inn Bethesda, 7335 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Patrick K Lai, Ph.D...

  3. A single institution experience with the new bethesda system for reporting thyroid cytopathology: correlation with existing cytologic, clinical, and histological data.

    Science.gov (United States)

    McElroy, Michele K; Mahooti, Sepi; Hasteh, Farnaz

    2014-07-01

    Our goal was to evaluate the Bethesda system (TBS) in comparison to the previously used system at our institution. One hundred consecutive thyroid fine needle aspirations (FNAs) and 45 consecutive indeterminate FNAs were reviewed by two cytopathology-boarded pathologists, diagnosed based on TBS and correlated with management and follow-up. Re-evaluation led to a diagnosis change in 48% of cases. Thirty-nine percent of benign cases were unsatisfactory under TBS. For malignant diagnoses the positive predictive value (PPV) was unchanged, while the negative predictive value (NPV) was slightly improved using TBS. Both the PPV and NPV were improved for actionable diagnoses. Inter-observer variability across all categories was in moderate agreement. Clinical management of both follicular lesion (FL) and indeterminate cases ranged from none to immediate surgery. Repeat FNA resolved the diagnosis in 50% of indeterminate cases. Indeterminate cases had an overall malignancy rate of 27%; higher in pre- (46%) than post-TBS cases (8%). Inter-observer variability between the reviewing pathologists and the original pathologists for indeterminate cases was fair, and between the two reviewing pathologists was moderate. Using TBS criteria increased the unsatisfactory rate and led to improved prediction of malignancy and actionable diagnoses. The pre-Bethesda diagnosis of FL at our institution led to inconsistent clinical management. Clinical management of patients with indeterminate diagnoses was essentially unchanged following adoption of TBS. The moderate inter-observer agreement between the reviewing pathologists may be related to level of cytology experience, strict adherence to TBS, and the exclusive use of cytomorphology for diagnosis. © 2014 Wiley Periodicals, Inc.

  4. A reconnaissance spatial and temporal assessment of methane and inorganic constituents in groundwater in bedrock aquifers, Pike County, Pennsylvania, 2012-13

    Science.gov (United States)

    Senior, Lisa A.

    2014-01-01

    Pike County in northeastern Pennsylvania is underlain by the Devonian-age Marcellus Shale and other shales, formations that have potential for natural gas development. During 2012–13, the U.S. Geological Survey in cooperation with the Pike County Conservation District conducted a reconnaissance study to assess baseline shallow groundwater quality in bedrock aquifers prior to possible shale-gas development in the county. For the spatial component of the assessment, 20 wells were sampled in summer 2012 to provide data on the occurrence of methane and other aspects of existing groundwater quality throughout the county, including concentrations of inorganic constituents commonly present at low levels in shallow, fresh groundwater but elevated in brines. For the temporal component of the assessment, 4 of the 20 wells sampled in summer 2012 were sampled monthly from July 2012 through June 2013 to provide data on seasonal variability in groundwater quality. All water samples were analyzed for major ions, nutrients, selected inorganic trace constituents (including metals and other elements), stable isotopes of water, radon-222, gross alpha- and gross beta-particle activity, dissolved gases (methane, ethane, and ethene), and, if possible, isotopic composition of methane. Additional analyses for boron and strontium isotopes, age-dating of water, and radium-226 were done on water samples collected from six wells in June 2013.

  5. BASEMAP, PIKE COUNTY, MS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  6. TERRAIN, PIKE COUNTY, MS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  7. mGluR5 stimulating Homer–PIKE formation initiates icariin induced cardiomyogenesis of mouse embryonic stem cells by activating reactive oxygen species

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Limin; Huang, Yujie; Zhang, Yingying [Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, No. 866, Yu Hang Tang Road, Hangzhou 310058 (China); Zhao, Qingwei [The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qing Chun Road, Hangzhou 310003 (China); Zheng, Bei; Lou, Yijia [Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, No. 866, Yu Hang Tang Road, Hangzhou 310058 (China); Zhu, Danyan, E-mail: zdyzxb@zju.edu.cn [Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, No. 866, Yu Hang Tang Road, Hangzhou 310058 (China)

    2013-06-10

    Icariin (ICA) has been reported to facilitate cardiac differentiation of mouse embryonic stem (ES) cells; however, the mechanism by which ICA induced cardiomyogenesis has not been fully elucidated yet. Here, an underlying signaling network including metabotropic glutamate receptor 5 (mGluR5), Homer, phosphatidylinositol 3-Kinase Enhancer (PIKE), phosphatidylinositol 3-Kinase (PI3K), reactive oxygen species (ROS) and nuclear factor-kappaB (NF-κB) was investigated in ICA induced cardiomyogenesis. Our results showed that the co-expression of mGluR5 together with α-actinin or Troponin T in embryoid bodies (EBs) treated with ICA was elevated to 10.86% and 9.62%, compared with the case in the control (4.04% and 3.45%, respectively). Exposure of EBs to ICA for 2 h remarkably increased the dimeric form of mGluR5, which was inhibited by small interfering RNA targeting mGluR5 (si-mGluR5). Moreover, the extracellular glutamate concentration in ICA treatment medium was elevated to 28.9±3.5 μM. Furthermore, the activation of mGluR5 by ICA triggered the formation of Homer–PIKE complex and activated PI3K, stimulating ROS generation and NF-κB nuclear translocation. Knockdown of mGluR5 or inhibition of PI3K by LY294002 blocked ICA induced cardiomyogenesis via repressing mGluR5 pathway, reducing ROS and NF-κB activation. These results revealed that the inducible mechanisms of ICA were related to activate mGluR5 pathway. -- Highlights: • ICA increased mGluR5 expression in cardiac differentiation of ES cells. • ICA enhanced the glutamate level and the receptor mGluR5 dimerization, stimulating the formation of Homer–PIKE complex. • Knockdown of mGluR5 or inhibition of PI3K by LY294002 inhibited ICA induced ROS generation and NF-κB nuclear translocation.

  8. Microsatellite DNA analysis of northern pike ( Esox lucius L.) populations: insights into the genetic structure and demographic history of a genetically depauperate species

    DEFF Research Database (Denmark)

    Jacobsen, B. H.; Hansen, Michael Møller; Loeschcke, V.

    2005-01-01

    The northern pike Esox lucius L. is a freshwater fish exhibiting pronounced population subdivision and low genetic variability. However, there is limited knowledge on phylogeographical patterns within the species, and it is not known whether the low genetic variability reflects primarily current...... low effective population sizes or historical bottlenecks. We analysed six microsatellite loci in ten populations from Europe and North America. Genetic variation was low, with the average number of alleles within populations ranging from 2.3 to 4.0 per locus. Genetic differentiation among populations...... was high (overall theta(ST) = 0.51; overall rho(ST) = 0.50). Multidimensional scaling analysis of genetic distances between populations and spatial analysis of molecular variance suggested a single phylogeographical race within the sampled populations from northern Europe, whereas North American...

  9. Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000

    Energy Technology Data Exchange (ETDEWEB)

    Kierkegaard, A.; Bignert, A.; Sellstroem, U.; Olsson, M.; Asplund, L.; Jansson, B.; Wit, C.A. de

    2004-07-01

    Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from Lake Bolmen for the years 1967-2000, are presented. All BDE congeners show increasing trends up to the mid-1980s ({sigma}5PBDE from 60 to 1600 pg/g wet weight in 1989, i.e. a more than 25-fold increase), and then decrease or level off. The decreasing trends of PBDEs after the 1980s were considerably slower in the present study than was found in a study of an environmental matrix from the Baltic Proper covering the same time period. This difference suggests local sources near Lake Bolmen. The MeO-BDEs show initially decreasing concentrations, which for 6-MeO-BDE47 continues until the early 1990s. The concentrations of 6-MeO-BDE47 in herring from five locations along the Swedish coast increased from south to north in the Baltic Sea. No correlation between the concentrations of the BDE congeners and the MeO-BDEs was observed, indicating sources other than PBDEs for these compounds. The presence of MeO-BDEs in fish from lakes with different characteristics suggests a natural production not favoured by eutrophication, or dependent on sampling season and geographical location. - PBDEs and MeO-BDEs show different temporal trends in pike from a Swedish lake suggesting different sources.

  10. Supplementation of lactobacilli improves growth, regulates microbiota composition and suppresses skeletal anomalies in juvenile pike-perch (Sander lucioperca) reared in recirculating aquaculture system (RAS): A pilot study.

    Science.gov (United States)

    Ljubobratovic, Uros; Kosanovic, Dejana; Vukotic, Goran; Molnar, Zsuzsanna; Stanisavljevic, Nemanja; Ristovic, Tijana; Peter, Geza; Lukic, Jovanka; Jeney, Galina

    2017-12-01

    This research aimed to test the effects of lactobacilli, applied to cultured pike-perch, either through hydrolyzed OTOHIME fish diet, or through Artemia nauplii, on fish growth, microbiota balance and skeletal development. On the 12th Day Post Hatching (DPH) fish were divided into following treatment groups: two groups received the combination of OTOHIME and nauplii enriched either with Lactobacillus paracasei BGHN14+Lactobacillus rhamnosus BGT10 or with Lactobacillus reuteri BGGO6-55+Lactobacillus salivarius BGHO1, and one group received OTOHIME hydrolyzed by BGHN14+BGT10 and non-enriched nauplii. Control group received non-enriched nauplii and non-hydrolyzed OTOHIME. The treatment lasted 14days and fish were sacrificed on the 26th DPH for the assessment of digestive enzyme activity and microbiota composition. Individual total lengths and individual body weights were recorded at the end of the treatments, on the 26th DPH, and also on the 45th DPH, in parallel with the evaluation of skeletal deformities and fish survival. Our results indicated positive effect of Artemia enriched with BGGO6-55+BGHO1 on fish growth, skeletal development and trypsin to chymotrypsin activity ratio (T/C), as an indicator of protein digestibility. Hydrolysis of OTOHIME was also associated with better skeletal development, higher T/C values and lower levels of Aeromonas and Mycobacterium spp., which are important fish pathogens. Though additional testing in larger cohort studies is needed, these observations are promising in terms of usage of probiotics for improved environmentally friendly production of pike-perch in Recirculating Aquaculture System (RAS). Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000

    International Nuclear Information System (INIS)

    Kierkegaard, A.; Bignert, A.; Sellstroem, U.; Olsson, M.; Asplund, L.; Jansson, B.; Wit, C.A. de

    2004-01-01

    Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from Lake Bolmen for the years 1967-2000, are presented. All BDE congeners show increasing trends up to the mid-1980s (Σ5PBDE from 60 to 1600 pg/g wet weight in 1989, i.e. a more than 25-fold increase), and then decrease or level off. The decreasing trends of PBDEs after the 1980s were considerably slower in the present study than was found in a study of an environmental matrix from the Baltic Proper covering the same time period. This difference suggests local sources near Lake Bolmen. The MeO-BDEs show initially decreasing concentrations, which for 6-MeO-BDE47 continues until the early 1990s. The concentrations of 6-MeO-BDE47 in herring from five locations along the Swedish coast increased from south to north in the Baltic Sea. No correlation between the concentrations of the BDE congeners and the MeO-BDEs was observed, indicating sources other than PBDEs for these compounds. The presence of MeO-BDEs in fish from lakes with different characteristics suggests a natural production not favoured by eutrophication, or dependent on sampling season and geographical location. - PBDEs and MeO-BDEs show different temporal trends in pike from a Swedish lake suggesting different sources

  12. Fine Needle Aspiration of Thyroid Nodules Using the Bethesda System for Reporting Thyroid Cytopathology: An Institutional Experience in a Rural Setting

    Directory of Open Access Journals (Sweden)

    Aili Guo

    2017-01-01

    Full Text Available Background. Fine needle aspiration (FNA remains the first-line diagnostic in management of thyroid nodules and reduces unnecessary surgeries. However, it is still challenging since cytological results are not always straightforward. This study aimed to examine the results of thyroid FNA using the Bethesda system for reporting thyroid cytopathology (TBSRTC to establish the level of accuracy of FNA procedures in a rural practice setting. Method. A retrospective chart review was conducted on existing thyroid FNA performed in a referral endocrine center between December 2011 and November 2015. Results. A total of 159 patients (18–88 years old and 236 nodule aspirations were performed and submitted for evaluation. 79% were benign, 3% atypia/follicular lesion of unknown significance (AUS/FLUS, 5% follicular neoplasm/suspicious for follicular neoplasm (FN/SFN, 4% suspicious for malignancy (one case was indeed an atypical parathyroid neoplasm by surgical pathology, 2% malignant, and 7% nondiagnostic. Two cases also had advanced molecular analysis on FNA specimens before thyroidectomy. Conclusion. The diagnostic yield of FNA cytology from our practice in a rural setting suggests that accuracy and specificity are comparable to results from larger centers.

  13. The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists

    Directory of Open Access Journals (Sweden)

    Mimi Kim

    2017-07-01

    Full Text Available Background The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea. Methods Questionnaire surveys were used for data collection on the fine needle aspiration (FNA of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed. Results Sixty out of 74 institutes answering the surveys reported the results of thyroid FNA in accordance with TBSRTC. The average malignancy rates for resected cases in 15 institutes were as follows: nondiagnostic, 45.6%; benign, 16.5%; atypical of undetermined significance, 68.8%; suspicious for follicular neoplasm (SFN, 30.2%; suspicious for malignancy, 97.5%; malignancy, 99.7%. Conclusions More than 80% of Korean institutes were using TBSRTC as of 2012. All malignancy rates other than the SFN and malignancy categories were higher than those reported by other countries. Therefore, the guidelines for treating patients with thyroid nodules in Korea should be revisited based on the malignancy rates reported in this study.

  14. Diagnostic Thyroidectomy May Be Preferable in Patients With Suspicious Ultrasonography Features After Cytopathology Diagnosis of AUS/FLUS in the Bethesda System

    Science.gov (United States)

    Lee, Yong Sang; Kim, Hyeung Kyoo; Chang, Hojin; Kim, Seok Mo; Kim, Bup-Woo; Chang, Hang-Seok; Park, Cheong Soo

    2015-01-01

    Abstract Atypia/follicular lesion of undetermined significance (AUS/FLUS) is a new category in the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) for which repeat fine-needle aspiration cytology (FNAC) is recommended. The aim of this study was to identify specific ultrasonography and clinical predictors of malignancy in a subset of thyroid nodules associated with cytology diagnoses of AUS/FLUS. Between January 2011 and December 2102, 5440 patients underwent thyroid surgery at our institution. Of these, 213 patients were diagnosed AUS/FLUS at the preoperative cytopathology diagnosis. The frequency of FNAC and ultrasonography images was compared between patients with cancerous and benign tumors based on their final pathology. Of the 213 patients, 158 (74.2%) were diagnosed with thyroid carcinoma in their final pathology reports. In univariate and multivariate analyses, the frequency of FNAC was not significantly correlated with the cancer diagnosis. Hypoechogenicity (odds ratio 2.521, P = 0.007) and microcalcification (odds ratio 3.247, P = 0.005) were statistically correlated with cancer risk. Although AUS/FLUS in cytopathology is recommended for repeating FNAC in BSRTC, we proposed that thyroid nodules with ultrasonography findings that suggest the possibility of cancer should undergo thyroidectomy with diagnostic intent. PMID:26705204

  15. Geochemical Characterization of Mine Waste, Mine Drainage, and Stream Sediments at the Pike Hill Copper Mine Superfund Site, Orange County, Vermont

    Science.gov (United States)

    Piatak, Nadine M.; Seal, Robert R.; Hammarstrom, Jane M.; Kiah, Richard G.; Deacon, Jeffrey R.; Adams, Monique; Anthony, Michael W.; Briggs, Paul H.; Jackson, John C.

    2006-01-01

    The Pike Hill Copper Mine Superfund Site in the Vermont copper belt consists of the abandoned Smith, Eureka, and Union mines, all of which exploited Besshi-type massive sulfide deposits. The site was listed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2004 due to aquatic ecosystem impacts. This study was intended to be a precursor to a formal remedial investigation by the USEPA, and it focused on the characterization of mine waste, mine drainage, and stream sediments. A related study investigated the effects of the mine drainage on downstream surface waters. The potential for mine waste and drainage to have an adverse impact on aquatic ecosystems, on drinking- water supplies, and to human health was assessed on the basis of mineralogy, chemical concentrations, acid generation, and potential for metals to be leached from mine waste and soils. The results were compared to those from analyses of other Vermont copper belt Superfund sites, the Elizabeth Mine and Ely Copper Mine, to evaluate if the waste material at the Pike Hill Copper Mine was sufficiently similar to that of the other mine sites that USEPA can streamline the evaluation of remediation technologies. Mine-waste samples consisted of oxidized and unoxidized sulfidic ore and waste rock, and flotation-mill tailings. These samples contained as much as 16 weight percent sulfides that included chalcopyrite, pyrite, pyrrhotite, and sphalerite. During oxidation, sulfides weather and may release potentially toxic trace elements and may produce acid. In addition, soluble efflorescent sulfate salts were identified at the mines; during rain events, the dissolution of these salts contributes acid and metals to receiving waters. Mine waste contained concentrations of cadmium, copper, and iron that exceeded USEPA Preliminary Remediation Goals. The concentrations of selenium in mine waste were higher than the average composition of eastern United States soils. Most mine waste was

  16. Research Needs for Magnetic Fusion Energy Sciences. Report of the Research Needs Workshop (ReNeW) Bethesda, Maryland, June 8-12, 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-06-08

    a strategic framework for realizing practical fusion energy. The portfolio is the product of ten months of fusion-community study and discussion, culminating in a Workshop held in Bethesda, Maryland, from June 8 to June 12, 2009. The Workshop involved some 200 scientists from Universities, National Laboratories and private industry, including several scientists from outside the US. Largely following the Basic Research Needs model established by the Office of Basic Energy Sciences (BES ), the Report presents a collection of discrete research activities, here called 'thrusts.' Each thrust is based on an explicitly identified question, or coherent set of questions, on the frontier of fusion science. It presents a strategy to find the needed answers, combining the necessary intellectual and hardware tools, experimental facilities, and computational resources into an integrated, focused program. The thrusts should be viewed as building blocks for a fusion program plan whose overall structure will be developed by OFES , using whatever additional community input it requests. Part I of the Report reviews the issues identified in previous fusion-community studies, which systematically identified the key research issues and described them in considerable detail. It then considers in some detail the scientific and technical means that can be used to address these is sues. It ends by showing how these various research requirements are organized into a set of eighteen thrusts. Part II presents a detailed and self-contained discussion of each thrust, including the goals, required facilities and tools for each. This Executive Summary focuses on a survey of the ReNeW thrusts. The following brief review of fusion science is intended to provide context for that survey. A more detailed discussion of fusion science can be found in an Appendix to this Summary, entitled 'A Fusion Primer.'

  17. Water quality, hydrology, and the effects of changes in phosphorus loading to Pike Lake, Washington County, Wisconsin, with special emphasis on inlet-to-outlet short-circuiting

    Science.gov (United States)

    Rose, William J.; Robertson, Dale M.; Mergener, Elizabeth A.

    2004-01-01

    Pike Lake is a 459-acre, mesotrophic to eutrophic dimictic lake in southeastern Wisconsin. Because of concern over degrading water quality in the lake associated with further development in its watershed, a study was conducted by the U.S. Geological Survey from 1998 to 2000 to describe the water quality and hydrology of the lake, quantify sources of phosphorus including the effects of short-circuiting of inflows, and determine how changes in phosphorus loading should affect the water quality of the lake. Measuring all significant water and phosphorus sources and estimating lesser sources was the method used to construct detailed water and phosphorus budgets. The Rubicon River, ungaged near-lake surface inflow, precipitation, and ground water provide 55, 20, 17, and 7 percent of the total inflow, respectively. Water leaves the lake through the Rubicon River outlet (87 percent) or by evaporation (13 percent). Total input of phosphorus to the lake was about 3,500 pounds in 1999 and 2,400 pounds in 2000. About 80 percent of the phosphorus was from the Rubicon River, about half of which came from the watershed and half from a waste-water treatment plant in Slinger, Wisconsin. Inlet-to-outlet short-circuiting of phosphorus is facilitated by a meandering segment of the Rubicon River channel through a marsh at the north end of the lake. It is estimated that 77 percent of phosphorus from the Rubicon River in monitoring year 1999 and 65 percent in monitoring year 2000 was short-circuited to the outlet without entering the main body of the lake.

  18. Polybrominated diphenyl ethers (PBDEs) and their methoxylated derivatives in pike from Swedish waters with emphasis on temporal trends, 1967-2000.

    Science.gov (United States)

    Kierkegaard, A; Bignert, A; Sellström, U; Olsson, M; Asplund, L; Jansson, B; De Wit, C A

    2004-07-01

    Temporal trends of five tetra- to hexabromodiphenyl ethers [BDE47, BDE99, BDE100, BDE153 and BDE154) and two methoxy-tetraBDEs [6-methoxy-2,2',4,4'- tetraBDE (6-MeO-BDE47) and 2'-methoxy-2,3',4,5'- tetraBDE (2'-MeO-BDE68)] in pike from Lake Bolmen for the years 1967-2000, are presented. All BDE congeners show increasing trends up to the mid-1980s (Sigma5PBDE from 60 to 1600 pg/g wet weight in 1989, i.e. a more than 25-fold increase), and then decrease or level off. The decreasing trends of PBDEs after the 1980s were considerably slower in the present study than was found in a study of an environmental matrix from the Baltic Proper covering the same time period. This difference suggests local sources near Lake Bolmen. The MeO-BDEs show initially decreasing concentrations, which for 6-MeO-BDE47 continues until the early 1990s. The concentrations of 6-MeO-BDE47 in herring from five locations along the Swedish coast increased from south to north in the Baltic Sea. No correlation between the concentrations of the BDE congeners and the MeO-BDEs was observed, indicating sources other than PBDEs for these compounds. The presence of MeO-BDEs in fish from lakes with different characteristics suggests a natural production not favoured by eutrophication, or dependent on sampling season and geographical location.

  19. Higher-order organisation of extremely amplified, potentially functional and massively methylated 5S rDNA in European pikes (Esox sp.).

    Science.gov (United States)

    Symonová, Radka; Ocalewicz, Konrad; Kirtiklis, Lech; Delmastro, Giovanni Battista; Pelikánová, Šárka; Garcia, Sonia; Kovařík, Aleš

    2017-05-18

    Pikes represent an important genus (Esox) harbouring a pre-duplication karyotype (2n = 2x = 50) of economically important salmonid pseudopolyploids. Here, we have characterized the 5S ribosomal RNA genes (rDNA) in Esox lucius and its closely related E. cisalpinus using cytogenetic, molecular and genomic approaches. Intragenomic homogeneity and copy number estimation was carried out using Illumina reads. The higher-order structure of rDNA arrays was investigated by the analysis of long PacBio reads. Position of loci on chromosomes was determined by FISH. DNA methylation was analysed by methylation-sensitive restriction enzymes. The 5S rDNA loci occupy exclusively (peri)centromeric regions on 30-38 acrocentric chromosomes in both E. lucius and E. cisalpinus. The large number of loci is accompanied by extreme amplification of genes (>20,000 copies), which is to the best of our knowledge one of the highest copy number of rRNA genes in animals ever reported. Conserved secondary structures of predicted 5S rRNAs indicate that most of the amplified genes are potentially functional. Only few SNPs were found in genic regions indicating their high homogeneity while intergenic spacers were more heterogeneous and several families were identified. Analysis of 10-30 kb-long molecules sequenced by the PacBio technology (containing about 40% of total 5S rDNA) revealed that the vast majority (96%) of genes are organised in large several kilobase-long blocks. Dispersed genes or short tandems were less common (4%). The adjacent 5S blocks were directly linked, separated by intervening DNA and even inverted. The 5S units differing in the intergenic spacers formed both homogeneous and heterogeneous (mixed) blocks indicating variable degree of homogenisation between the loci. Both E. lucius and E. cisalpinus 5S rDNA was heavily methylated at CG dinucleotides. Extreme amplification of 5S rRNA genes in the Esox genome occurred in the absence of significant pseudogenisation

  20. 21 CFR 312.145 - Guidance documents.

    Science.gov (United States)

    2010-04-01

    ... of Drug Information, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New... Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448. [65 FR... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Guidance documents. 312.145 Section 312.145 Food...

  1. 10 CFR 110.44 - Physical security standards.

    Science.gov (United States)

    2010-01-01

    ... (corrected). (2) Information obtained through country visits, information exchanges, or other sources... at the NRC library, 11545 Rockville Pike, Rockville, Maryland 20852-2738. A copy is available for inspection at the National Archives and Records Administration (NARA). For information on the availability of...

  2. 76 FR 58312 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-09-20

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of September 19, 2011 There are no meetings scheduled for the week of September 19, 2011... be webcast live at the Web address-- http://www.nrc.gov . Week of October 3, 2011--Tentative Thursday...

  3. 77 FR 20077 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-04-03

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...-0223). This meeting will be webcast live at the Web address--www.nrc.gov. Week of April 9, 2012... webcast live at the Web address--www.nrc.gov. Week of April 16, 2012--Tentative There are no meetings...

  4. 77 FR 3513 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-01-24

    ..., 27, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of January 23, 2012 There are no meetings scheduled for the week of January 23... (Public Meeting). (Contact: Diane Sieracki, (301) 415-3297.) This meeting will be webcast live at the Web...

  5. 75 FR 12583 - Sunshine Act; Meeting Notice

    Science.gov (United States)

    2010-03-16

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Week of..., 301-415-3152). This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week of...) (Contact: Jose Ibarra, 301-415-2581). This meeting will be webcast live at the Web address-- http://www.nrc...

  6. 77 FR 46528 - Sunshine Act Meeting

    Science.gov (United States)

    2012-08-03

    ...: Nuclear Regulatory Commission. DATES: Week of August 6, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. ADDITIONAL ITEMS TO BE CONSIDERED: Week of... Proceeding (June 18, 2012) (Tentative). This meeting will be webcast live at the Web address--www.nrc.gov...

  7. 75 FR 13800 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-03-23

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Week of... Ibarra, 301-415-2581). This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week... live at the Web address-- http://www.nrc.gov . Thursday, April 8, 2010 9:30 a.m. Briefing on Regional...

  8. 78 FR 49306 - Sunshine Act Meeting

    Science.gov (United States)

    2013-08-13

    ...' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of August 12...--Tentative Monday August 26, 2013 2:00 p.m. Discussion of Management and Personnel Issues (Closed--Ex. 2 and...) (Contact: Michelle Hayes, 301-415-8375) This meeting will be webcast live at the Web address--www.nrc.gov 3...

  9. 77 FR 52072 - Sunshine Act Meeting

    Science.gov (United States)

    2012-08-28

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...) (Contact: Richard Correia, 301-251-7430). This meeting will be webcast live at the Web address--www.nrc.gov. Friday, September 14, 2012 11:00 a.m. Discussion of Management and Personnel Issues (Closed--Ex. 2 and 6...

  10. 78 FR 36604 - Sunshine Act Meetings

    Science.gov (United States)

    2013-06-18

    ...' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of June 17, 2013... a.m. Briefing on Security Issues (Closed--Ex. 1) Wednesday, July 10, 2013 9:00 a.m. Briefing on NRC... web cast live at the Web address--www.nrc.gov. 10:30 a.m. Briefing on NRC International Activities...

  11. 78 FR 4476 - Sunshine Act; Meeting Notice

    Science.gov (United States)

    2013-01-22

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... live at the Web address--www.nrc.gov. 9:00 a.m. Briefing on Public Participation in NRC Regulatory Decision- Making (Public Meeting) (Contact: Lance Rakovan, 301-415-2589). This meeting will be webcast live...

  12. 78 FR 60331 - Sunshine Act Meeting

    Science.gov (United States)

    2013-10-01

    ..., October 7, 14, 21, 28, November 4, 2013. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of September 30, 2013 There are no meetings scheduled..., 301-415-1711). This meeting will be webcast live at the Web address-- http://www.nrc.gov/ . Friday...

  13. 77 FR 21601 - Sunshine Act Meeting

    Science.gov (United States)

    2012-04-10

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of April 9, 2012 Tuesday, April 10, 2012 9 a.m. Briefing on the Final Report of the Blue...). This meeting will be webcast live at the Web address--www.nrc.gov Week of April 16, 2012--Tentative...

  14. 78 FR 77736 - Sunshine Act Meetings

    Science.gov (United States)

    2013-12-24

    ..., 2013, January 6, 13, 20, 27, 2014. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of December 23, 2013 There are no meetings scheduled... Casks (Public Meeting); (Contact: Kevin Witt, 301-415-2145) This meeting will be webcast live at the Web...

  15. 75 FR 71472 - Sunshine Act Notice

    Science.gov (United States)

    2010-11-23

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Week of..., 2010--Tentative Tuesday, November 30, 2010 1 p.m. Briefing on Security Issues (Closed--Ex. 1). Week of... live at the Web address--http:// www.nrc.gov Week of December 20, 2010--Tentative Tuesday, December 21...

  16. 77 FR 40385 - Sunshine Act Meetings

    Science.gov (United States)

    2012-07-09

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and closed. Week of July 9, 2012 Tuesday, July 10, 2012 9:30 a.m. Strategic Programmatic Overview of the... webcast live at the Web address: www.nrc.gov . Week of July 16, 2012--Tentative There are no meetings...

  17. 78 FR 51234 - Sunshine Act Meetings

    Science.gov (United States)

    2013-08-20

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... (Closed--Ex. 2 and 6). Tuesday, August 27, 2013 9:00 a.m. Briefing on NRC's Construction Activities (Public Meeting); (Contact: Michelle Hayes, 301-415-8375). This meeting will be webcast live at the Web...

  18. 78 FR 25320 - Sunshine Federal Register Notice

    Science.gov (United States)

    2013-04-30

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of April 29, 2013 There are no meetings scheduled for the week of April 29, 2013. Week of...) (Public Meeting) (Contact: Kristin Davis, 301-287-0707) This meeting will be webcast live at the Web...

  19. 76 FR 77574 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2011-12-13

    ..., 16, 2012. Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and closed. Week of December 12, 2011 Tuesday, December 13, 2011 9 a.m. Briefing on NFPA 805 Fire Protection (Public Meeting), (Contact: Alex Klein, (301) 415-2822.) This meeting will be webcast live at the...

  20. 78 FR 19757 - Sunshine Act Meetings

    Science.gov (United States)

    2013-04-02

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland STATUS: Public and Closed Week of... Quash Subpoena Filed by the Shaw Group, Inc. (Tentative) This meeting will be webcast live at the Web... meeting will be webcast live at the Web address--www.nrc.gov Week of April 8, 2013--Tentative There are no...

  1. 75 FR 23822 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-05-04

    ... 3, 10, 17, 24, 31, June 7, 2010. Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and closed. Week of May 3, 2010 Tuesday, May 4, 2010 9:30 a.m. Briefing...-2673). This meeting will be Webcast live at the Web address-- http://www.nrc.gov . 10:30 a.m...

  2. 77 FR 61644 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-10-10

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...: Kevin Mattern, 301-492-3221). This meeting will be webcast live at the Web address--www.nrc.gov. Week of...); (Contact: Michael Hay, 817-200-1527). This meeting will be webcast live at the Web address--www.nrc.gov...

  3. 78 FR 6150 - Sunshine Act; Meeting Notice

    Science.gov (United States)

    2013-01-29

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of January 28, 2013 Thursday, January 31, 2013 8:55 a.m. Affirmation Session (Public Meeting... be webcast live at the Web address--www.nrc.gov. 9:00 a.m. Briefing on Public Participation in NRC...

  4. 76 FR 14107 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-03-15

    ..., 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and closed. Week of March 14, 2011 There are no meetings scheduled for the week of March 14, 2011... meeting will be Webcast live at the Web address-- http://www.nrc.gov . Week of March 28, 2011--Tentative...

  5. 75 FR 1657 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2010-01-12

    .... Place: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Week of January 11, 2010 Tuesday, January 12, 2010 9:30 a.m. Briefing on Office of Nuclear...: Marshall Kohen, 301-415-5436.) This meeting will be webcast live at the Web address-- http://www.nrc.gov...

  6. 78 FR 79021 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2013-12-27

    ... 30, 2013, January 6, 13, 20, 27, February 3, 2014. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of December 30, 2013 There are no... to Dry Casks (Public Meeting) (Contact: Kevin Witt, 301-415-2145). This meeting will be webcast live...

  7. 75 FR 15752 - Sunshine Act Notice

    Science.gov (United States)

    2010-03-30

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...: Jose Ibarra, 301-415-2581.) This meeting will be webcast live at the Web address-- http://www.nrc.gov... live at the Web address-- http://www.nrc.gov . Thursday, April 8, 2010 9:30 a.m. Briefing on Regional...

  8. 77 FR 10575 - Sunshine Act Meetings

    Science.gov (United States)

    2012-02-22

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... meeting will be webcast live at the Web address--www.nrc.gov. 9 a.m.--Briefing on Fort Calhoun (Public Meeting) (Contact: Jeff Clark, 817-860-8147). This meeting will be webcast live at the Web address--www...

  9. 75 FR 22166 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-04-27

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. Status: Public and Closed. Week of... (Public Meeting). (Contact: Michael Raddatz, 301-492-3108.) This meeting will be webcast live at the Web....) This meeting will be webcast live at the Web address-- http://www.nrc.gov . 10:30 a.m. Discussion of...

  10. 75 FR 65674 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-10-26

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of October 25, 2010 Tuesday, October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Week of... meeting will be webcast live at the Web address-- http://www.nrc.gov . Friday, November 5, 2010 9:30 a.m...

  11. 78 FR 23960 - Sunshine Act Meetings

    Science.gov (United States)

    2013-04-23

    ...' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of April 22, 2013... Meeting) (Contact: Brett Rini, 301-251-7615). This meeting will be webcast live at the Web address--www.nrc.gov. 2:30 p.m. Discussion of Management and Personnel Issues (Closed--Ex. 2 and 6). Tuesday April...

  12. 76 FR 388 - Sunshine Act Notice

    Science.gov (United States)

    2011-01-04

    ... Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of January 3, 2011... Tuesday, January 11, 2011 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2). Week of January 17... Meeting). (Contact: Diane Sieracki, 301-415-3297.) This meeting will be Webcast live at the Web address...

  13. 77 FR 1521 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-01-10

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of January 9, 2012 Wednesday, January 11, 2012 10 a.m. Discussion of Management and Personnel Issues (Closed...) This meeting will be webcast live at the Web address: www.nrc.gov . Week of January 16, 2012--Tentative...

  14. 78 FR 8203 - Sunshine Act Meetings

    Science.gov (United States)

    2013-02-05

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... Meeting) (Contact: Ken Karwoski, 301-415-2752) This meeting will be webcast live at the web address--www... Uranium Recovery (Public Meeting) (Contact: Bill von Till, 301-415-0598) This meeting will be webcast live...

  15. 76 FR 17460 - SUNSHINE FEDERAL REGISTER NOTICE

    Science.gov (United States)

    2011-03-29

    ..., June 6, 13, 2011. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of March 28, 2011 Tuesday, March 29, 2011 9 a.m. Briefing on Small... live at the Web address-- http://www.nrc.gov . Thursday, March 31, 2011 2:30 p.m. Discussion of...

  16. 78 FR 41128 - Sunshine Act Meetings

    Science.gov (United States)

    2013-07-09

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of July 8, 2013 Tuesday, July 9, 2013 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). Wednesday...: Karen Henderson, 301-415-0202). This meeting will be webcast live at the Web address--www.nrc.gov. 10:30...

  17. 78 FR 44179 - Sunshine Act Meetings

    Science.gov (United States)

    2013-07-23

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... Hayes, 301-415-8375). This meeting will be webcast live at the Web address-- http://www.nrc.gov . 3:00 p.m. Briefing on NRC International Activities (Closed--Ex. 1 & 9) (Contact: Karen Henderson, 301-415...

  18. 78 FR 72931 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2013-12-04

    ... 2, 9, 16, 23, 30, 2013, January 6, 2014. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of December 2, 2013 There are no meetings scheduled for... Dry Casks (Public Meeting) (Contact: Kevin Witt, 301-415-2145). This meeting will be webcast live at...

  19. 78 FR 35071 - Sunshine Federal Register Notice

    Science.gov (United States)

    2013-06-11

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of..., 2013 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Wednesday, July 10, 2013 9:00 a.m. Briefing...) This meeting will be webcast live at the Web address-- http://www.nrc.gov . 10:30 a.m. Briefing on NRC...

  20. 76 FR 61403 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-10-04

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...). (Contact: Karen Henderson, 301-415-0202.) This meeting will be webcast live at the Web address-- http://www..., 301-415-3172.) This meeting will be webcast live at the Web address-- http://www.nrc.gov . Wednesday...

  1. 78 FR 28258 - Sunshine Act Meetings

    Science.gov (United States)

    2013-05-14

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...) (Public Meeting) (Contact: Kristin Davis, 301-287- 0707). This meeting will be webcast live at the Web... Security Issues (Closed--Ex. 1). Wednesday, May 29, 2013 9:00 a.m. Briefing on Results of the Agency Action...

  2. 77 FR 18271 - Notice of Sunshine Act Meeting

    Science.gov (United States)

    2012-03-27

    ... 26, April 2, 9, 16, 23, 30, 2012. PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of March 26, 2012 Tuesday, March 27, 2012 8:55 a.m... meeting will be webcast live at the Web address--www.nrc.gov. 9 a.m. Briefing on License Renewal for...

  3. 78 FR 962 - Sunshine Act Meetings

    Science.gov (United States)

    2013-01-07

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...: Michael Hay, 817-200-1527) This meeting will be webcast live at the Web address--www.nrc.gov Wednesday..., 2012) (Tentative) This meeting will be webcast live at the Web address--www.nrc.gov 9:00 a.m. Briefing...

  4. 77 FR 67838 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-11-14

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of November 12, 2012 There are no meetings scheduled for the week of November 12, 2012. Week... Licensing Program (Public Meeting) (Contact: Jack McHale, 301-415-3254). This meeting will be webcast live...

  5. 76 FR 24933 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-05-03

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...). (Contact: Robert Kahler, 301-415-7528.) This meeting will be webcast live at the Web address-- http://www...) (Contact: Nathan Sanfilippo, 301-415-3951.) [[Page 24934

  6. 77 FR 74883 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-12-18

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of December 17, 2012 There are no meetings scheduled for the week of December 17, 2012. Week... Calhoun (Public Meeting) (Contact: Michael Hay, 817-200-1527) This meeting will be webcast live at the Web...

  7. 78 FR 52990 - Sunshine Act Meetings Notice

    Science.gov (United States)

    2013-08-27

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of August 26, 2013 Monday August 26, 2013 2:00 p.m. Discussion of Management and Personnel Issues (Closed... Meeting) (Contact: Michelle Hayes, 301-415-8375). This meeting will be webcast live at the Web address...

  8. 77 FR 33252 - Sunshine Act Meeting

    Science.gov (United States)

    2012-06-05

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and closed. Week of June 4, 2012 Thursday, June 7, 2012 9:25 a.m. Affirmation Session (Public Meeting... meeting will be webcast live at the Web address--www.nrc.gov. 9:30 a.m. Meeting with the Advisory...

  9. 76 FR 26775 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2011-05-09

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...-415-3951). This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week of May 16...) (Public Meeting) (Contact: Rani Franovich, 301-415-1868). This meeting will be webcast live at the Web...

  10. 77 FR 24543 - Sunshine Act Meeting Noice

    Science.gov (United States)

    2012-04-24

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... webcast live at the Web address--www.nrc.gov. Week of April 30, 2012--Tentative Monday, April 30, 2012 9...: Kristin Davis, 301-492- 2208). This meeting will be webcast live at the Web address--www.nrc.gov. Week of...

  11. 78 FR 21171 - Sunshine Act Meetings

    Science.gov (United States)

    2013-04-09

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of... Meeting) (Contact: Brett Rini, 301-251-7615) This meeting will be webcast live at the Web address--www.nrc.gov. 2:30 p.m. Discussion of Management and Personnel Issues (Closed-- Ex. 2 and 6) Tuesday, April 23...

  12. 78 FR 18376 - Sunshine Act Meetings

    Science.gov (United States)

    2013-03-26

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...-0223). This meeting will be webcast live at the Web address--www.nrc.gov. Week of April 8, 2013...) (Contact: Brett Rini, 301-251-7615). This meeting will be webcast live at the Web address--www.nrc.gov. 2...

  13. 76 FR 23341 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-04-26

    .... PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of April 25, 2011 Thursday, April 28, 2011 9:30 a.m. Briefing on the Status of NRC Response...-415-1711) This meeting will be webcast live at the Web address-- http://www.nrc.gov . Week of May 2...

  14. 76 FR 8788 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-02-15

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...); (Contact: Margie Kotzalas, 301-415-1727). This meeting will be Webcast live at the Web address-- http://www... be Webcast live at the Web address-- http://www.nrc.gov . Week of March 7, 2011--Tentative There are...

  15. 77 FR 70488 - Sunshine Federal Register Notice

    Science.gov (United States)

    2012-11-26

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland STATUS: Public and Closed. Week of... Meeting) (Contact: Jack McHale, 301-415-3254). This meeting will be webcast live at the Web address--www.nrc.gov. Wednesday, November 28, 2012 9:00 a.m. Discussion of Management and Personnel Issues (Closed...

  16. 76 FR 6837 - Sunshine Federal Register Notice

    Science.gov (United States)

    2011-02-08

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of...) (Contact: Shana Helton, 301-415-7198). This meeting will be webcast live at the Web address-- http://www... live at the Web address-- http://www.nrc.gov . Week of February 28, 2011--Tentative Tuesday, March 1...

  17. 77 FR 25761 - Sunshine Act Meetings

    Science.gov (United States)

    2012-05-01

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. [[Page... webcast live at the Web address--www.nrc.gov. Week of May 7, 2012--Tentative Friday, May 11, 2012 9:00 a.m... Quichocho, 301-415-0209). This meeting will be webcast live at the Web address--www.nrc.gov. Week of May 14...

  18. 78 FR 16893 - Sunshine Act Meetings

    Science.gov (United States)

    2013-03-19

    ...: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. [[Page... Flannery, 301-415-0223) This meeting will be webcast live at the Web address--www.nrc.gov. Week of April 8... Accident (Public Meeting) (Contact: William D. Reckley, 301- 415-7490) This meeting will be webcast live at...

  19. 78 FR 19332 - Sunshine Act Meeting

    Science.gov (United States)

    2013-03-29

    ...: Nuclear Regulatory Commission. DATE: Week of April 1, 2013 PLACE: Commissioners' Conference Room, 11555 Rockville Pike, Rockville, Maryland STATUS: Public and Closed Week of April 1, 2013--Tentative Tuesday April... the Shaw Group, Inc. (Tentative) This meeting will be webcast live at the Web address-- www.nrc.gov...

  20. 75 FR 27841 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR

    Science.gov (United States)

    2010-05-18

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR The ACRS Subcommittee on EPR will hold a meeting on May 21, 2010, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public attendance. The agenda for...

  1. 77 FR 74696 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000...

    Science.gov (United States)

    2012-12-17

    ... NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on AP-1000; Notice of Meeting The ACRS Subcommittee on AP-1000 will hold a meeting on January 18, 2013, Room T-2B1, 11545 Rockville Pike, Rockville, Maryland. The entire meeting will be open to public...

  2. 75 FR 15639 - Revision of the Requirements for Constituent Materials

    Science.gov (United States)

    2010-03-30

    ... preservative, except that a preservative need not be added to Yellow Fever Vaccine; Poliovirus Vaccine Live... and Research (CBER) or the Director of the Center for Drug Evaluation and Research (CDER), as... and Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD...

  3. 78 FR 70064 - Submission for OMB Review; 30-day Comment Request: Generic Clearance To Support Programs and...

    Science.gov (United States)

    2013-11-22

    ... Institute, 11400 Rockville Pike, Room 707, Rockville, MD 20852 or call non-toll- free number 301-480-0541 or Email your request, including your address to: [email protected] . Formal requests for... (NIH) Institutes. Along with the analysis, NCI's ongoing education and outreach effort has increased...

  4. 78 FR 70306 - Distribution of In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use...

    Science.gov (United States)

    2013-11-25

    ... Development (HFM-40), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, 1401...: Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug... Research (HFM-17), Food and Drug Administration, 1401 Rockville Pike, Suite 200N, Rockville, MD 20852-1448...

  5. 75 FR 35493 - Guidance for Industry on Systemic Lupus Erythematosus-Developing Medical Products for Treatment...

    Science.gov (United States)

    2010-06-22

    ...: The Food and Drug Administration (FDA) is announcing the availability of a guidance for industry... and Research (CBER), Food and Drug Administration, 1401 Rockville Pike, suite 200N, Rockville, MD...-0002, 301- 796-2280; or Stephen Ripley, Center for Biologics Evaluation and Research (HFM- 17), Food...

  6. 75 FR 42466 - Notice of Availability of Draft Environmental Impact Statement and Public Meeting for the AREVA...

    Science.gov (United States)

    2010-07-21

    ... need should be brought to the attention of Ms. Tarsha Moon at (800) 362-5642, ext. 6745, no later than..., located at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland 20852. Members..., air quality, geology and soils, water resources, ecological resources, noise, transportation, public...

  7. 75 FR 36447 - Notice of Availability of Draft Environmental Impact Statement and Public Meetings for the...

    Science.gov (United States)

    2010-06-25

    ... be brought to the attention of Ms. Jennifer Davis no later than July 8, 2010, to provide NRC staff...), located at One White Flint North, 11555 Rockville Pike (first floor), Rockville, Maryland, 20852. Members... occupational health, air quality, water resources, waste management, geology and soils, noise, ecology...

  8. 76 FR 66075 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-10-25

    ...: Non-HIV Diagnostics, Food Safety, Sterilization/Disinfection and Bioremediation. Date: November 17-18... Hotel, 4300 Military Road, NW., Washington, DC 20015. Contact Person: Gagan Pandya, PhD, Scientific... applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person...

  9. 76 FR 30397 - Notice of Availability of Environmental Assessment and Finding of No Significant Impact for the...

    Science.gov (United States)

    2011-05-25

    .... The NRC staff considered the following environmental resource areas in its evaluation: Air quality... concludes that the proposed action will not result in a significant effect on the quality of the human... North, 11555 Rockville Pike, Rockville, MD 20852. The PDR reproduction contractor will copy documents...

  10. 75 FR 7489 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2010-02-19

    ... review and evaluate grant applications. Place: Legacy Hotel and Meeting Center, 1775 Rockville Pike, Rockville, MD 20852. Contact Person: Lalita D. Palekar, PhD, Scientific Review Officer, Special Review and... Institute Special Emphasis Panel; NCI Cancer Nanotechnology Training (R25) and Career Development Award (K99...

  11. 77 FR 16278 - Advisory Committee on Reactor Safeguards: Notice of Meeting

    Science.gov (United States)

    2012-03-20

    ..., 11545 Rockville Pike, Rockville, Maryland. Thursday, April 12, 2012, Conference Room T2-B1, 11545....: Selected Chapters of the Safety Evaluation Report (SER) with Open Items Associated with the Calvert Cliffs... chapters of the NRC staff's Safety Evaluation Report (SER) with open items associated with the Calvert...

  12. 75 FR 16203 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on EPR; Notice...

    Science.gov (United States)

    2010-03-31

    ... hold a meeting on April 20-21, 2010, at 11545 Rockville Pike, T2- B1, Rockville, Maryland. The entire... review Chapters 4, 5 and 17 of the Safety Evaluation Report with Open Items associated with the staff's... a.m.-5 p.m. The Subcommittee will review Chapter 12 of the Safety Evaluation Report with Open Items...

  13. 76 FR 30404 - Advisory Committee On Reactor Safeguards; Meeting

    Science.gov (United States)

    2011-05-25

    ... Room T2-B1, 11545 Rockville Pike, Rockville, Maryland 8:30 a.m.-8:35 a.m.: Opening Remarks by the ACRS... Alloy Cladding.'' 10:45 a.m.-11:45 a.m.: Revised Safety Evaluation Report Associated with the License... to the safety evaluation report associated with the license renewal application for the Hope Creek...

  14. 76 FR 6199 - Enhanced Weapons, Firearms Background Checks, and Security Event Notifications

    Science.gov (United States)

    2011-02-03

    ... comments, contact us directly at 301-415-1677. Hand deliver comments to: 11555 Rockville Pike, Rockville..., President Bush signed into law the Energy Policy Act of 2005 (EPAct), Public Law 109-58, 119 Stat. 594 (2005... locked containers which are sealed with a high-integrity, tamper-indicating device (TID) (e.g., ``ready...

  15. 10 CFR 4.5 - Communications and reports.

    Science.gov (United States)

    2010-01-01

    ... otherwise indicated, communications and reports relating to this part may be sent to the NRC by mail...'s offices at 11555 Rockville Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, via Electronic Information Exchange, or CD-ROM. Electronic submissions must be made...

  16. 10 CFR 25.9 - Communications.

    Science.gov (United States)

    2010-01-01

    ... Director, Division of Facilities and Security, Mail Stop T7-D57, and sent either by mail to the U.S... Rockville Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, Electronic Information Exchange, or CD-ROM. Electronic submissions must be made in a manner that enables the...

  17. 77 FR 2766 - Facility Operating License Amendment from Duke Energy Carolinas, LLC., Catawba Nuclear Station...

    Science.gov (United States)

    2012-01-19

    ..., 11555 Rockville Pike, Rockville, Maryland 20852. NRC's Agencywide Documents Access and Management System..., leakage is modeled as flow through a porous medium via the use of the Darcy equation. The leakage model is... structural margins of the SG tubes for both [[Page 2768

  18. Multimodality Molecular Imaging (FDG-PET/CT, US Elastography, and DWI-MRI) as Complimentary Adjunct for Enhancing Diagnostic Confidence in Reported Intermediate Risk Category Thyroid Nodules on Bethesda Thyroid Cytopathology Reporting System

    International Nuclear Information System (INIS)

    Basu, Sandip; Mahajan, Abhishek; Arya, Supreeta

    2016-01-01

    The potential complimentary role of various molecular imaging modalities [fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT), ultrasound (US)-elastography, and diffusion weighted imaging-magnetic resonance imaging (DWI-MRI)] in characterizing thyroid nodules, which have been designated as “intermediate risk category” on the Bethesda thyroid cytopathology reporting system (BTCRS), is illustrated in this communication. The clinical cases described (category III thyroid nodules on BTCRS) show the imaging features and the final diagnostic impressions rendered by the interpreting physicians with the modalities that have been independently compared in a tabular format at the end; of particular note is the high negative predictive value of these (specifically FDG-PET/CT), which could aid in enhancing the diagnostic confidence in the reported “intermediate risk category” thyroid nodules, a “gray zone” from the patient management viewpoint

  19. SURVEY, PIKE COUNTY, KY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Survey data includes spatial datasets and data tables necessary to digitally represent data collected in the survey phase of the study. (Source: FEMA Guidelines and...

  20. HYDRAULICS, PIKE COUNTY, KENTUCKY, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  1. HYDRAULICS, PIKE COUNTY, OHIO, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — "Recent developments in digital terrain and geospatial database management technology make is possible to protect this investment for existing and future projects to...

  2. About the Eye

    Medline Plus

    Full Text Available ... Lane, MSC 9300 Bethesda, MD 20892-9300 (Courier services use: Rockville, MD 20852) 301-451-2020 Research ... NEI Website Manager . Department of Health and Human Services | The National Institutes of Health | USA.gov NIH… ...

  3. Medline Plus

    Full Text Available ... made. ©2018 BroadcastMed About MedlinePlus Site ... Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated on ...

  4. About MedlinePlus

    Science.gov (United States)

    ... Want to learn more? Guide to Healthy Web Surfing Sign Up for Email Updates Training Materials ... Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page ...

  5. 78 FR 59040 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2013-09-25

    ... Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Brian R. Pike, Ph.D., Scientific... Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88, Minority Access to Research...

  6. Recommendations for a barrier island breach management plan for Fire Island National Seashore, including the Otis Pike High Dune Wilderness Area, Long Island, New York

    Science.gov (United States)

    Williams, S. Jeffress; Foley, Mary K.

    2007-01-01

    The U.S Army Corps of Engineers, New York District is developing engineering plans, including economic costs and benefits, for storm damage reduction along an 83 mile stretch of the coastal barrier islands and beaches on the south shore of Long Island, NY from Fire Island Inlet east to the Montauk Point headland. The plan, expected to include various alternatives for storm protection and erosion mitigation, is referred to as the Fire Island to Montauk Point Reformulation Plan (FIMP). These plans are expected to follow the Corps of Engineers’ Environmental Operating Principles striving for long term environmental sustainability and balance between environmental protection and protection of human health and property. Fire Island National Seashore (FIIS), a 19,579 acre unit of the National Park System includes a 32 mile long coastal barrier island located within the FIMP project area. A seven-mile section of the park, Otis Pike Fire Island High Dune Wilderness Area, is also a designated Federal Wilderness Area. The FIIS includes not only the barrier island and sand dunes, but also several islands, sand flats and wetlands landward of the barrier, submerged parts of Great South Bay shoreface, extending approximately 4,000 feet into the bay with the inner shelf region extending approximately 1,000 feet seaward of the Fire Island shoreline. The Fire Island barrier islands, a sand-starved system dominated by highly dynamic processes, are struggling to maintain their integrity in the face of sea-level rise and storms. Adding to the dilemma is that development on the barriers and the mainland has increased greatly during the past 50 years. As such, managers and decision makers in federal agencies, state agencies and local governments are challenged to balance tradeoffs between protection of lives and property, public access and long term conservation of natural habitats and processes and the plants and animals that depend on these habitats. National Park Service (NPS

  7. High Energy Physics Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and High Energy Physics, June 10-12, 2015, Bethesda, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Habib, Salman [Argonne National Lab. (ANL), Argonne, IL (United States); Roser, Robert [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Antypas, Katie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dart, Eli [Esnet, Berkeley, CA (United States); Dosanjh, Sudip [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hack, James [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Monga, Inder [Esnet, Berkeley, CA (United States); Papka, Michael E. [Argonne National Lab. (ANL), Argonne, IL (United States); Riley, Katherine [Argonne National Lab. (ANL), Argonne, IL (United States); Rotman, Lauren [Esnet, Berkeley, CA (United States); Straatsma, Tjerk [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Jack [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Tim [Argonne National Lab. (ANL), Argonne, IL (United States); Almgren, A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Amundson, J. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Bailey, Stephen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bard, Deborah [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bloom, Ken [Univ. of Nebraska, Lincoln, NE (United States); Bockelman, Brian [Univ. of Nebraska, Lincoln, NE (United States); Borgland, Anders [SLAC National Accelerator Lab., Menlo Park, CA (United States); Borrill, Julian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Boughezal, Radja [Argonne National Lab. (ANL), Argonne, IL (United States); Brower, Richard [Boston Univ., MA (United States); Cowan, Benjamin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Finkel, Hal [Argonne National Lab. (ANL), Argonne, IL (United States); Frontiere, Nicholas [Argonne National Lab. (ANL), Argonne, IL (United States); Fuess, Stuart [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Ge, Lixin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Gnedin, Nick [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Gottlieb, Steven [Indiana Univ., Bloomington, IN (United States); Gutsche, Oliver [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Han, T. [Indiana Univ., Bloomington, IN (United States); Heitmann, Katrin [Argonne National Lab. (ANL), Argonne, IL (United States); Hoeche, Stefan [SLAC National Accelerator Lab., Menlo Park, CA (United States); Ko, Kwok [SLAC National Accelerator Lab., Menlo Park, CA (United States); Kononenko, Oleksiy [SLAC National Accelerator Lab., Menlo Park, CA (United States); LeCompte, Thomas [Argonne National Lab. (ANL), Argonne, IL (United States); Li, Zheng [SLAC National Accelerator Lab., Menlo Park, CA (United States); Lukic, Zarija [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mori, Warren [Univ. of California, Los Angeles, CA (United States); Ng, Cho-Kuen [SLAC National Accelerator Lab., Menlo Park, CA (United States); Nugent, Peter [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Oleynik, Gene [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); O’Shea, Brian [Michigan State Univ., East Lansing, MI (United States); Padmanabhan, Nikhil [Yale Univ., New Haven, CT (United States); Petravick, Donald [Univ. of Illinois, Urbana, IL (United States). National Center for Supercomputing Applications; Petriello, Frank J. [Argonne National Lab. (ANL), Argonne, IL (United States); Pope, Adrian [Argonne National Lab. (ANL), Argonne, IL (United States); Power, John [Argonne National Lab. (ANL), Argonne, IL (United States); Qiang, Ji [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Reina, Laura [Florida State Univ., Tallahassee, FL (United States); Rizzo, Thomas Gerard [SLAC National Accelerator Lab., Menlo Park, CA (United States); Ryne, Robert [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Schram, Malachi [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Spentzouris, P. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Toussaint, Doug [Univ. of Arizona, Tucson, AZ (United States); Vay, Jean Luc [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Viren, B. [Brookhaven National Lab. (BNL), Upton, NY (United States); Wuerthwein, Frank [Univ. of California, San Diego, CA (United States); Xiao, Liling [SLAC National Accelerator Lab., Menlo Park, CA (United States); Coffey, Richard [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-11-29

    The U.S. Department of Energy (DOE) Office of Science (SC) Offices of High Energy Physics (HEP) and Advanced Scientific Computing Research (ASCR) convened a programmatic Exascale Requirements Review on June 10–12, 2015, in Bethesda, Maryland. This report summarizes the findings, results, and recommendations derived from that meeting. The high-level findings and observations are as follows. Larger, more capable computing and data facilities are needed to support HEP science goals in all three frontiers: Energy, Intensity, and Cosmic. The expected scale of the demand at the 2025 timescale is at least two orders of magnitude — and in some cases greater — than that available currently. The growth rate of data produced by simulations is overwhelming the current ability of both facilities and researchers to store and analyze it. Additional resources and new techniques for data analysis are urgently needed. Data rates and volumes from experimental facilities are also straining the current HEP infrastructure in its ability to store and analyze large and complex data volumes. Appropriately configured leadership-class facilities can play a transformational role in enabling scientific discovery from these datasets. A close integration of high-performance computing (HPC) simulation and data analysis will greatly aid in interpreting the results of HEP experiments. Such an integration will minimize data movement and facilitate interdependent workflows. Long-range planning between HEP and ASCR will be required to meet HEP’s research needs. To best use ASCR HPC resources, the experimental HEP program needs (1) an established, long-term plan for access to ASCR computational and data resources, (2) the ability to map workflows to HPC resources, (3) the ability for ASCR facilities to accommodate workflows run by collaborations potentially comprising thousands of individual members, (4) to transition codes to the next-generation HPC platforms that will be available at ASCR

  8. Before-after, control-impact analysis of evidence for the impacts of water level on Walleye, Northern Pike and Yellow Perch in lakes of the Rainy-Namakan complex (MN, USA and ON, CA.

    Directory of Open Access Journals (Sweden)

    James H Larson

    Full Text Available Water level (WL fluctuations in lakes influence many aspects of ecosystem processes. Concern about the potential impact of WL fluctuations on fisheries was one of the factors that motivated the decision in 2000 to alter the management of WL in the Rainy-Namakan reservoir complex (on the border between the U.S. state of Minnesota and the Canadian province of Ontario. We used a Before-After, Control-Impact (BACI framework to identify potential impacts of the change in WL management to Walleye, Northern Pike and Yellow Perch catch per unit effort (CPUE. The CPUE of these species from 1990-1999 and from 2005-2014 were compared in four impact lakes (Lake Kabetogama, Namakan Lake, Rainy Lake and Sand Point Lake and two control lakes (Lake of the Woods and Lake Vermilion using a simple Bayesian model. Changes in fish CPUE in the impact lakes were often similar to changes that occurred in at least one control lake. The only change that was not similar to changes in control lakes was an increase of Yellow Perch in Lake Kabetogama. The two control lakes often differed substantially from each other, such that if only one had been available our conclusions about the role of WL management on fisheries would be very different. In general, identifying cause-and-effect relationships in observational field data is very difficult, and the BACI analysis used here does not specify a causative mechanism, so co-occurring environmental and management changes may obscure the effect of WL management.

  9. 78 FR 38087 - Sunshine Act Meetings

    Science.gov (United States)

    2013-06-25

    ...' Conference Room, 11555 Rockville Pike, Rockville, Maryland. STATUS: Public and Closed. Week of June 24, 2013..., 2013 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Wednesday, July 10, 2013 9:00 a.m. Briefing...). This meeting will be webcast live at the Web address--www.nrc.gov. 10:30 a.m. Briefing on NRC...

  10. Symposium (International) (4th) on DETONATION Held at White Oak, Maryland on 12-15 October 1965.

    Science.gov (United States)

    1965-10-15

    Rockville Pike Sevran (93), France White OakSilver Spring, Md. Rockville, Maryland Jean C. Bergon C. J. Aronson Centre d’Etudes de Gramat B. M. Butcher...Lab. Direction des Etudes et P. 0. Box 808 Fabrication d’Armements Hiram E. Driscoll Livermore, Calif. 94551 Centre d’Etudes de Gramat Hercules...Powder Co. Gramat (Lot), France Port Ewven, N. Y. 12466 David Finlayson Naval Weapons Lab. Charles B. Dale Dahlgren, Va. Naval Propellant Plant Brian Dunne

  11. Floodplain Mapping Submission for PIKE County MS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  12. Automated turn pike using PLC and SCADA

    Science.gov (United States)

    Silpa Sreedhar, P.; Aiswarya, P.; Kathirvelan, J.

    2017-11-01

    We propose a smart turnpike based on Programmable Logic Controller (PLC) and Supervisory Control and Data Acquisition Systems (SCADA) in this paper. In this work, the basic idea is to measure the weight of the vehicles and classify them according to its weight to the respective lanes. It is difficult for the turnpike people to monitor the whole process all the time. So, this PLC based diversion system can be implemented in turnpikes to reduce the difficulties. This method will work based on weight sensors (piezo-resistive) whose output will be fed to a PLC, which will control the vehicle diversion. Using SCADA software, the whole process can be monitored from a remote area. The algorithm developed in this successfully installed in real time system.

  13. Floodplain Mapping for Pike County, KY

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — he Floodplain Mapping/Redelineation study deliverables depict and quantify the flood risks for the study area. The primary risk classifications used are the...

  14. DCS Terrain Submission for Pike County, KY

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix M: Data Capture Standards, describes the digital topographic data that were used to create...

  15. 75 FR 6401 - Medical Devices Regulated by the Center for Biologics Evaluation and Research; Availability of...

    Science.gov (United States)

    2010-02-09

    ... Biologics Evaluation and Research (HFM-17), Food and Drug Administration, suite 200N, 1401 Rockville Pike... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2009-M-0513] Medical Devices Regulated by the Center for Biologics Evaluation and Research; Availability of Summaries...

  16. 76 FR 44964 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on U.S...

    Science.gov (United States)

    2011-07-27

    ... Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on August 18, 2011, Room T-2B3, 11545 Rockville Pike... the meeting, if possible, so that appropriate arrangements can be made. Thirty-five hard copies of...

  17. 77 FR 74697 - Meeting of the ACRS, Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting

    Science.gov (United States)

    2012-12-17

    ..., Subcommittee on U.S. Evolutionary Power Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Evolutionary Power Reactor (U.S. EPR) will hold a meeting on January 17, 2013, Room T-2B1, 11545 Rockville Pike... be made. Thirty-five hard copies of each presentation or handout should be provided to the DFO thirty...

  18. 75 FR 64749 - Request for Comments on the Use of Electronic Signatures for NRC Documents Related to the Medical...

    Science.gov (United States)

    2010-10-20

    ... Pike, Rockville, Maryland. NRC's Agencywide Documents Access and Management System (ADAMS): Publicly... systems exclusively. NRC is seeking comments on acceptable forms of electronic signatures for documents... system that generates the electronic document must have functions that provide a legible document for the...

  19. Rubinstein-Taybi syndrome

    Science.gov (United States)

    ... is noticeable after birth Slow development of cognitive skills Slow development of motor skills accompanied by low muscle tone Other signs and ... Guidelines Viewers & Players MedlinePlus Connect for EHRs For Developers U.S. National Library of Medicine 8600 Rockville Pike, ...

  20. 10 CFR 21.5 - Communications.

    Science.gov (United States)

    2010-01-01

    ... this part must be addressed to the NRC's Document Control Desk, and sent by mail to the U.S. Nuclear... Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, Electronic Information Exchange, or CD-ROM. Electronic submissions must be made in a manner that enables the NRC to...

  1. 10 CFR 20.1007 - Communications.

    Science.gov (United States)

    2010-01-01

    ... addressed to the Executive Director for Operations (EDO), and sent either by mail to the U.S. Nuclear... Pike, Rockville, Maryland; or, where practicable, by electronic submission, for example, via Electronic Information Exchange, or CD-ROM. Electronic submissions must be made in a manner that enables the NRC to...

  2. Fundamental physics at the intensity frontier: Report of the workshop held December 2011 in Rockville, MD

    International Nuclear Information System (INIS)

    Hewett, J.L.; Weerts, H.; Brock, R.; Butler, J.N.; Casey, B.C.K.; Lu, Z.T.; Wagner, C.E.M.; Dietrich, M.R.; Djurcic, Z.; Goodman, M.; Green, J.P.; Holt, R.J.; Mueller, P.; Paley, J.; Reimer, P.; Singh, J.; Upadhye, A.

    2012-01-01

    Particle physics aims to understand the universe around us. The Standard Model of particle physics describes the basic structure of matter and forces, to the extent we have been able to probe thus far. However, it leaves some big questions unanswered. Some are within the Standard Model itself, such as why there are so many fundamental particles and why they have different masses. In other cases, the Standard Model simply fails to explain some phenomena, such as the observed matter-antimatter asymmetry in the universe, the existence of dark matter and dark energy, and the mechanism that reconciles gravity with quantum mechanics. These gaps lead us to conclude that the universe must contain new and unexplored elements of Nature. Most of particle and nuclear physics is directed towards discovering and understanding these new laws of physics. These questions are best pursued with a variety of approaches, rather than with a single experiment or technique. Particle physics uses three basic approaches, often characterized as exploration along the cosmic, energy, and intensity frontiers. Each employs different tools and techniques, but they ultimately address the same fundamental questions. This allows a multi-pronged approach where attacking basic questions from different angles furthers knowledge and provides deeper answers, so that the whole is more than a sum of the parts. A coherent picture or underlying theoretical model can more easily emerge, to be proven correct or not. The intensity frontier explores fundamental physics with intense sources and ultra-sensitive, sometimes massive detectors. It encompasses searches for extremely rare processes and for tiny deviations from Standard Model expectations. Intensity frontier experiments use precision measurements to probe quantum effects. They typically investigate very large energy scales, even higher than the kinematic reach of high energy particle accelerators. The science addresses basic questions, such as: Are there new sources of CP violation? Is there CP violation in the leptonic sector? Are neutrinos their own antiparticles? Do the forces unify? Is there a weakly coupled hidden sector that is related to dark matter? Do new symmetries exist at very high energy scales? To identify the most compelling science opportunities in this area, the workshop Fundamental Physics at the Intensity Frontier was held in December 2011, sponsored by the Office of High Energy Physics in the US Department of Energy Office of Science. Participants investigated the most promising experiments to exploit these opportunities and described the knowledge that can be gained from such a program. The workshop generated much interest in the community, as witnessed by the large and energetic participation by a broad spectrum of scientists. This document chronicles the activities of the workshop, with contributions by more than 450 authors. The workshop organized the intensity frontier science program along six topics that formed the basis for working groups: experiments that probe (i) heavy quarks, (ii) charged leptons, (iii) neutrinos, (iv) proton decay, (v) light, weakly interacting particles, and (vi) nucleons, nuclei, and atoms. The conveners for each working group included an experimenter and a theorist working in the field and an observer from the community at large. The working groups began their efforts well in advance of the workshop, holding regular meetings and soliciting written contributions. Specific avenues of exploration were identified by each working group. Experiments that study rare strange, charm, and bottom meson decays provide a broad program of measurements that are sensitive to new interactions. Charged leptons, particularly muons and taus, provide a precise probe for new physics because the Standard Model predictions for their properties are very accurate. Research at the intensity frontier can reveal CP violation in the lepton sector, and elucidate whether neutrinos are their own antiparticles. A very weakly coupled hidden-sector that may comprise the dark matter in the universe could be discovered. The search for proton decay can probe the unification of the forces with unprecedented reach and test sacrosanct symmetries to very high scales. Detecting an electric dipole moment for the neutron, or neutral atoms, could establish a clear signal for new physics, while limits on such a measurement would place severe constraints on many new theories. This workshop marked the first instance where discussion of these diverse programs was held under one roof. As a result, it was realized that this broad effort has many connections; a large degree of synergy exists between the different areas and they address similar questions. Results from one area were found to be pertinent to experiments in another domain.

  3. Online Opportunist: Mary Ellen Icaza--Montgomery County Public Libraries, Rockville, MD

    Science.gov (United States)

    Library Journal, 2004

    2004-01-01

    When Mary Ellen Icaza became Electronic Services Librarian at Montgomery County Public Libraries, she noticed that the readers' services information on the library web site was invisible, even to librarians. "And if staff can't find it," she says, "customers can't." She set out to help people find that material-and to turn a…

  4. Fundamental physics at the intensity frontier. Report of the workshop held December 2011 in Rockville, MD.

    Energy Technology Data Exchange (ETDEWEB)

    Hewett, J.L.; Weerts, H.; Brock, R.; Butler, J.N.; Casey, B.C.K.; Lu, Z.T.; Wagner, C.E.M.; Dietrich, M.R.; Djurcic, Z.; Goodman, M.; Green, J.P.; Holt, R.J.; Mueller, P.; Paley, J.; Reimer, P.; Singh, J.; Upadhye, A. (High Energy Physics); ( PHY); (Stanford Linear Accelerator Center); (Univ. of Michigan); (Fermi National Accelerator Laboratory)

    2012-06-05

    Particle physics aims to understand the universe around us. The Standard Model of particle physics describes the basic structure of matter and forces, to the extent we have been able to probe thus far. However, it leaves some big questions unanswered. Some are within the Standard Model itself, such as why there are so many fundamental particles and why they have different masses. In other cases, the Standard Model simply fails to explain some phenomena, such as the observed matter-antimatter asymmetry in the universe, the existence of dark matter and dark energy, and the mechanism that reconciles gravity with quantum mechanics. These gaps lead us to conclude that the universe must contain new and unexplored elements of Nature. Most of particle and nuclear physics is directed towards discovering and understanding these new laws of physics. These questions are best pursued with a variety of approaches, rather than with a single experiment or technique. Particle physics uses three basic approaches, often characterized as exploration along the cosmic, energy, and intensity frontiers. Each employs different tools and techniques, but they ultimately address the same fundamental questions. This allows a multi-pronged approach where attacking basic questions from different angles furthers knowledge and provides deeper answers, so that the whole is more than a sum of the parts. A coherent picture or underlying theoretical model can more easily emerge, to be proven correct or not. The intensity frontier explores fundamental physics with intense sources and ultra-sensitive, sometimes massive detectors. It encompasses searches for extremely rare processes and for tiny deviations from Standard Model expectations. Intensity frontier experiments use precision measurements to probe quantum effects. They typically investigate very large energy scales, even higher than the kinematic reach of high energy particle accelerators. The science addresses basic questions, such as: Are there new sources of CP violation? Is there CP violation in the leptonic sector? Are neutrinos their own antiparticles? Do the forces unify? Is there a weakly coupled hidden sector that is related to dark matter? Do new symmetries exist at very high energy scales? To identify the most compelling science opportunities in this area, the workshop Fundamental Physics at the Intensity Frontier was held in December 2011, sponsored by the Office of High Energy Physics in the US Department of Energy Office of Science. Participants investigated the most promising experiments to exploit these opportunities and described the knowledge that can be gained from such a program. The workshop generated much interest in the community, as witnessed by the large and energetic participation by a broad spectrum of scientists. This document chronicles the activities of the workshop, with contributions by more than 450 authors. The workshop organized the intensity frontier science program along six topics that formed the basis for working groups: experiments that probe (i) heavy quarks, (ii) charged leptons, (iii) neutrinos, (iv) proton decay, (v) light, weakly interacting particles, and (vi) nucleons, nuclei, and atoms. The conveners for each working group included an experimenter and a theorist working in the field and an observer from the community at large. The working groups began their efforts well in advance of the workshop, holding regular meetings and soliciting written contributions. Specific avenues of exploration were identified by each working group. Experiments that study rare strange, charm, and bottom meson decays provide a broad program of measurements that are sensitive to new interactions. Charged leptons, particularly muons and taus, provide a precise probe for new physics because the Standard Model predictions for their properties are very accurate. Research at the intensity frontier can reveal CP violation in the lepton sector, and elucidate whether neutrinos are their own antiparticles. A very weakly coupled hidden-sector that may comprise the dark matter in the universe could be discovered. The search for proton decay can probe the unification of the forces with unprecedented reach and test sacrosanct symmetries to very high scales. Detecting an electric dipole moment for the neutron, or neutral atoms, could establish a clear signal for new physics, while limits on such a measurement would place severe constraints on many new theories. This workshop marked the first instance where discussion of these diverse programs was held under one roof. As a result, it was realized that this broad effort has many connections; a large degree of synergy exists between the different areas and they address similar questions. Results from one area were found to be pertinent to experiments in another domain.

  5. 77 FR 65728 - Notice of Sunshine Act Meetings

    Science.gov (United States)

    2012-10-30

    ....nrc.gov. Thursday, November 29, 2012 2:30 p.m. Briefing on Security issues (Closed Ex-1) Week of... Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2). Week of November 12...

  6. 75 FR 62894 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-10-13

    ..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1). Week of November 1, 2010... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting), (Contact: Michael Fuller, 301-415-0520). This meeting will be...

  7. 75 FR 61227 - Sunshine Act: Notice of Meeting

    Science.gov (United States)

    2010-10-04

    ... on Security Issues (Closed--Ex. 1). Week of November 1, 2010--Tentative Tuesday, November 2, 2010 9..., 2010 1:30 p.m.--NRC All Employees Meeting (Public Meeting), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m.--Briefing on Medical Issues (Public...

  8. 77 FR 64835 - Sunshine Act Meeting

    Science.gov (United States)

    2012-10-23

    ...:30 p.m. Briefing on Security issues (Closed Ex-1) * The schedule for Commission meetings is subject...), Marriott Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852 Thursday, November 8, 2012 9:30 a.m. Discussion of Management Issues (Closed--Ex. 2) Week of November 12, 2012--Tentative There are no meetings...

  9. 75 FR 64367 - Sunshine Federal Register Notice

    Science.gov (United States)

    2010-10-19

    ..., October 26, 2010 9:30 a.m. Briefing on Security Issues (Closed--Ex. 1) Week of November 1, 2010--Tentative... Bethesda North Hotel, 5701 Marinelli Road, Rockville, MD 20852. Wednesday, October 20, 2010 9 a.m. Briefing on Medical Issues (Public Meeting). (Contact: Michael Fuller, 301-415-0520.) This meeting will be...

  10. Ask a Scientist: What is Color Blindness?

    Medline Plus

    Full Text Available ... MSC 9300 Bethesda, MD 20892-9300 (Courier services use: Rockville, MD 20852) 301-451-2020 Research at NEI Office of the Scientific Director Office of the Clinical Director Laboratories, Sections and Units Division of Epidemiology and Clinical ...

  11. Five year follow-up of a randomized controlled trial on warming and humidification of insufflation gas in laparoscopic colonic surgery--impact on small bowel obstruction and oncologic outcomes.

    Science.gov (United States)

    Sammour, Tarik; Hill, Andrew G

    2015-04-01

    Warming and humidification of insufflation gas has been shown to reduce adhesion formation and tumor implantation in the laboratory setting, but clinical evidence is lacking. We aimed to test the hypothesis that warming and humidification of insufflation CO2 would lead to reduced adhesion formation, and improve oncologic outcomes in laparoscopic colonic surgery. This was a 5-year follow-up of a multicenter, double-blinded, randomized, controlled trial investigating warming and humidification of insufflation gas. The study group received warmed (37°C), humidified (98%) insufflation carbon dioxide, and the control group received standard gas (19°C, 0%). All other aspects of patient care were standardized. Admissions for small bowel obstruction were recorded, as well as whether management was operative or nonoperative. Local and systemic cancer recurrence, 5-year overall survival, and cancer specific survival rates were also recorded. Eighty two patients were randomized, with 41 in each arm. Groups were well matched at baseline. There was no difference between the study and control groups in the rate of clinical small bowel obstruction (5.7% versus 0%, P 0.226); local recurrence (6.5% versus 6.1%, P 1.000); overall survival (85.7% versus 82.1%, P 0.759); or cancer-specific survival (90.3% versus 87.9%, P 1.000). Warming and humidification of insufflation CO2 in laparoscopic colonic surgery does not appear to confer a clinically significant long term benefit in terms of adhesion reduction or oncological outcomes, although a much larger randomized controlled trial (RCT) would be required to confirm this. ClinicalTrials.gov Trial identifier: NCT00642005; US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.

  12. Five Year Follow-Up of a Randomized Controlled Trial on Warming and Humidification of Insufflation Gas in Laparoscopic Colonic Surgery—Impact on Small Bowel Obstruction and Oncologic Outcomes

    Science.gov (United States)

    Sammour, Tarik; Hill, Andrew G.

    2015-01-01

    Warming and humidification of insufflation gas has been shown to reduce adhesion formation and tumor implantation in the laboratory setting, but clinical evidence is lacking. We aimed to test the hypothesis that warming and humidification of insufflation CO2 would lead to reduced adhesion formation, and improve oncologic outcomes in laparoscopic colonic surgery. This was a 5-year follow-up of a multicenter, double-blinded, randomized, controlled trial investigating warming and humidification of insufflation gas. The study group received warmed (37°C), humidified (98%) insufflation carbon dioxide, and the control group received standard gas (19°C, 0%). All other aspects of patient care were standardized. Admissions for small bowel obstruction were recorded, as well as whether management was operative or nonoperative. Local and systemic cancer recurrence, 5-year overall survival, and cancer specific survival rates were also recorded. Eighty two patients were randomized, with 41 in each arm. Groups were well matched at baseline. There was no difference between the study and control groups in the rate of clinical small bowel obstruction (5.7% versus 0%, P 0.226); local recurrence (6.5% versus 6.1%, P 1.000); overall survival (85.7% versus 82.1%, P 0.759); or cancer-specific survival (90.3% versus 87.9%, P 1.000). Warming and humidification of insufflation CO2 in laparoscopic colonic surgery does not appear to confer a clinically significant long term benefit in terms of adhesion reduction or oncological outcomes, although a much larger randomized controlled trial (RCT) would be required to confirm this. ClinicalTrials.gov Trial identifier: NCT00642005; US National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA. PMID:25875541

  13. Thyroid fine-needle aspiration and the bethesda classification system

    DEFF Research Database (Denmark)

    Larsen, Louise Vølund; Egset, Alice Viktoria; Holm, Camilla

    2018-01-01

    INTRODUCTION: Fine-needle aspiration (FNA) is a cornerstone in diagnosing thyroid nodules. For decades, Danish FNA have been categorised into the groups: “FNA not per-formed”, “Inadequate”, “Cystic”, “Inconclusive”, “Benign”, “Suspicious”, “Malignant” and “Information missing”. Internationally...

  14. Patient Workload Profile: National Naval Medical Center (NNMC), Bethesda, MD.

    Science.gov (United States)

    1980-06-01

    AD-A09a 729 WESTEC SERVICES NC SAN DIEGOCA0S / PATIENT WORKLOAD PROFILE: NATIONAL NAVAL MEDICAL CENTER NNMC),- ETC(U) JUN 80 W T RASMUSSEN, H W...provides site workload data for the National Naval Medical Center (NNMC) within the following functional support areas: Patient Appointment...on managing medical and patient data, thereby offering the health care provider and administrator more powerful capabilities in dealing with and

  15. Public attitudes to organ donation in South Africa | Pike | South ...

    African Journals Online (AJOL)

    Public attitudes to organ donation may be influenced by cultural beliefs as well as racial prejudices and superstitions. In South Africa we are able to examine these issues from both a Firstand a Third-World perspective. In this study the attitudes of 1 299 urban white, 625 rural black and 826 urban black South Africans were ...

  16. DCS Terrain Submittal for Pike County, Georgia, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Terrain data, as defined in FEMA Guidelines and Specifications, Appendix N: Data Capture Standards, describes the digital topographic data that was used to create...

  17. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, PIKE COUNTY, AL

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  18. Fusion Simulation Project. Workshop Sponsored by the U.S. Department of Energy, Rockville, MD, May 16-18, 2007

    Energy Technology Data Exchange (ETDEWEB)

    Kritz, A.; Keyes, D.

    2007-05-18

    The mission of the Fusion Simulation Project is to develop a predictive capability for the integrated modeling of magnetically confined plasmas. This FSP report adds to the previous activities that defined an approach to integrated modeling in magnetic fusion. These previous activities included a Fusion Energy Sciences Advisory Committee panel that was charged to study integrated simulation in 2002. The report of that panel [Journal of Fusion Energy 20, 135 (2001)] recommended the prompt initiation of a Fusion Simulation Project. In 2003, the Office of Fusion Energy Sciences formed a steering committee that developed a project vision, roadmap, and governance concepts [Journal of Fusion Energy 23, 1 (2004)]. The current FSP planning effort involved forty-six physicists, applied mathematicians and computer scientists, from twenty-one institutions, formed into four panels and a coordinating committee. These panels were constituted to consider: Status of Physics Components, Required Computational and Applied Mathematics Tools, Integration and Management of Code Components, and Project Structure and Management. The ideas, reported here, are the products of these panels, working together over several months and culminating in a three-day workshop in May 2007.

  19. Fusion Simulation Project. Workshop sponsored by the U.S. Department of Energy Rockville, MD, May 16-18, 2007

    Energy Technology Data Exchange (ETDEWEB)

    None

    2007-05-16

    The mission of the Fusion Simulation Project is to develop a predictive capability for the integrated modeling of magnetically confined plasmas. This FSP report adds to the previous activities that defined an approach to integrated modeling in magnetic fusion. These previous activities included a Fusion Energy Sciences Advisory Committee panel that was charged to study integrated simulation in 2002. The report of that panel [Journal of Fusion Energy 20, 135 (2001)] recommended the prompt initiation of a Fusion Simulation Project. In 2003, the Office of Fusion Energy Sciences formed a steering committee that developed a project vision, roadmap, and governance concepts [Journal of Fusion Energy 23, 1 (2004)]. The current FSP planning effort involved forty-six physicists, applied mathematicians and computer scientists, from twenty-one institutions, formed into four panels and a coordinating committee. These panels were constituted to consider: Status of Physics Components, Required Computational and Applied Mathematics Tools, Integration and Management of Code Components, and Project Structure and Management. The ideas, reported here, are the products of these panels, working together over several months and culminating in a three-day workshop in May 2007.

  20. Fusion Simulation Project. Workshop sponsored by the U.S. Department of Energy Rockville, MD, May 16-18, 2007

    International Nuclear Information System (INIS)

    2007-01-01

    The mission of the Fusion Simulation Project is to develop a predictive capability for the integrated modeling of magnetically confined plasmas. This FSP report adds to the previous activities that defined an approach to integrated modeling in magnetic fusion. These previous activities included a Fusion Energy Sciences Advisory Committee panel that was charged to study integrated simulation in 2002. The report of that panel (Journal of Fusion Energy 20, 135 (2001)) recommended the prompt initiation of a Fusion Simulation Project. In 2003, the Office of Fusion Energy Sciences formed a steering committee that developed a project vision, roadmap, and governance concepts (Journal of Fusion Energy 23, 1 (2004)). The current FSP planning effort involved forty-six physicists, applied mathematicians and computer scientists, from twenty-one institutions, formed into four panels and a coordinating committee. These panels were constituted to consider: Status of Physics Components, Required Computational and Applied Mathematics Tools, Integration and Management of Code Components, and Project Structure and Management. The ideas, reported here, are the products of these panels, working together over several months and culminating in a three-day workshop in May 2007.

  1. Fusion Simulation Project. Workshop Sponsored by the U.S. Department of Energy, Rockville, MD, May 16-18, 2007

    International Nuclear Information System (INIS)

    Kritz, A.; Keyes, D.

    2007-01-01

    The mission of the Fusion Simulation Project is to develop a predictive capability for the integrated modeling of magnetically confined plasmas. This FSP report adds to the previous activities that defined an approach to integrated modeling in magnetic fusion. These previous activities included a Fusion Energy Sciences Advisory Committee panel that was charged to study integrated simulation in 2002. The report of that panel [Journal of Fusion Energy 20, 135 (2001)] recommended the prompt initiation of a Fusion Simulation Project. In 2003, the Office of Fusion Energy Sciences formed a steering committee that developed a project vision, roadmap, and governance concepts [Journal of Fusion Energy 23, 1 (2004)]. The current FSP planning effort involved forty-six physicists, applied mathematicians and computer scientists, from twenty-one institutions, formed into four panels and a coordinating committee. These panels were constituted to consider: Status of Physics Components, Required Computational and Applied Mathematics Tools, Integration and Management of Code Components, and Project Structure and Management. The ideas, reported here, are the products of these panels, working together over several months and culminating in a three-day workshop in May 2007

  2. Terminology and classification aspects of the Bethesda System for Reporting Thyroid Cytopathology

    Directory of Open Access Journals (Sweden)

    G V Semkina

    2012-12-01

    Full Text Available The article is devoted to the relevance of Betesda System for Reporting Thyroid Cytopathology. This article summarizes recent data on the main differences and advantages of new classification system. Application of the Betesda System for Reporting Thyroid Cytopathology leads to the increased sensitivity and specificity of FNA.

  3. Validation of microsatellite instability histology scores with Bethesda guidelines in hereditary nonpolyposis colorectal cancer

    Directory of Open Access Journals (Sweden)

    Mustafa Kaya

    2017-01-01

    Conclusions: The MSI scoring systems, MsPath, and PathScore, are reliable systems and effectively correlated with BG for predicting patients who need advanced analysis techniques because of the risk of HNPCC.

  4. Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability

    OpenAIRE

    Umar, Asad; Boland, C. Richard; Terdiman, Jonathan P.; Syngal, Sapna; de la Chapelle, Albert; Rüschoff, Josef; Fishel, Richard; Lindor, Noralane M.; Burgart, Lawrence J.; Hamelin, Richard; Hamilton, Stanley R.; Hiatt, Robert A.; Jass, Jeremy; Lindblom, Annika; Lynch, Henry T.

    2004-01-01

    Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and because of the need for a better understanding of the clinical and histologic manifestations of HNPCC, the National Cancer Institute hosted an international workshop on HNPCC in 1996, which led to...

  5. Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.

    Science.gov (United States)

    Joseph, Jeymohan; Cinque, Paola; Colosi, Deborah; Dravid, Ameet; Ene, Luminita; Fox, Howard; Gabuzda, Dana; Gisslen, Magnus; Beth Joseph, Sarah; Letendre, Scott; Mukerji, Shibani S; Nath, Avindra; Perez-Valero, Ignacio; Persaud, Deborah; Price, Richard W; Rao, Vasudev R; Sacktor, Ned; Swanstrom, Ronald; Winston, Alan; Wojna, Valerie; Wright, Edwina; Spudich, Serena

    2016-10-05

    CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

  6. Atypical Squamous Cells of Undetermined Significance: Bethesda Classification and Association with Human Papillomavirus

    Directory of Open Access Journals (Sweden)

    Ana Cristina Macêdo Barcelos

    2011-01-01

    Full Text Available Introduction. To analyze patients with atypical squamous cells of undetermined significance (ASCUS through a cytology review and the presence of microbiological agents, with consideration of colposcopy and semiannual tracking. Methods. 103 women with ASCUS were reviewed and reclassified: normal/inflammatory, ASCUS, low-grade squamous intraepithelial lesion (LSIL, or high-grade squamous intraepithelial lesion (HSIL. If ASCUS confirmed, it was subclassified in reactive or neoplastic ASCUS, ASC-US, or ASC-H; and Regione Emilia Romagna Screening Protocol. Patients underwent a colposcopic examination, and test for Candida sp., bacterial vaginosis, Trichomonas vaginalis, and human papillomavirus (HPV were performed. Results. Upon review, ASCUS was diagnosis in 70/103 (67.9%, being 38 (54.2% reactive ASCUS and 32 (45.71% neoplastic ASCUS; 62 (88.5% ASC-US and 8 (11.41% ASC-H. ASCUS (Regione Protocol, respectively 1-5: 15 (21.4%, 19 (27.1%, 3 (27.1%, 16 (22.8%, and 1 (1.4%. A higher number of cases of cervical intraepithelial neoplasia (CIN II/III in the biopsies of patients with ASC-H compared to ASC-US (P=.0021. High-risk HPV test and presence of CIN II/III are more frequent in ASC-H than ASC-US (P=.031. Conclusions. ASC-H is associated with clinically significant disease. High-risk HPV-positive status in the triage for colposcopy of patients with ASC-US is associated with increased of CIN.

  7. Advanced Scientific Computing Research Exascale Requirements Review. An Office of Science review sponsored by Advanced Scientific Computing Research, September 27-29, 2016, Rockville, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Almgren, Ann [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); DeMar, Phil [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Vetter, Jeffrey [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Riley, Katherine [Argonne Leadership Computing Facility, Argonne, IL (United States); Antypas, Katie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bard, Deborah [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Coffey, Richard [Argonne National Lab. (ANL), Argonne, IL (United States); Dart, Eli [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Science Network; Dosanjh, Sudip [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hack, James [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Monga, Inder [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Science Network; Papka, Michael E. [Argonne National Lab. (ANL), Argonne, IL (United States); Rotman, Lauren [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Science Network; Straatsma, Tjerk [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Jack [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bernholdt, David E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bethel, Wes [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bosilca, George [Univ. of Tennessee, Knoxville, TN (United States); Cappello, Frank [Argonne National Lab. (ANL), Argonne, IL (United States); Gamblin, Todd [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Habib, Salman [Argonne National Lab. (ANL), Argonne, IL (United States); Hill, Judy [Oak Ridge Leadership Computing Facility, Oak Ridge, TN (United States); Hollingsworth, Jeffrey K. [Univ. of Maryland, College Park, MD (United States); McInnes, Lois Curfman [Argonne National Lab. (ANL), Argonne, IL (United States); Mohror, Kathryn [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Moore, Shirley [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Moreland, Ken [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Roser, Rob [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States); Shende, Sameer [Univ. of Oregon, Eugene, OR (United States); Shipman, Galen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Williams, Samuel [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-06-20

    The widespread use of computing in the American economy would not be possible without a thoughtful, exploratory research and development (R&D) community pushing the performance edge of operating systems, computer languages, and software libraries. These are the tools and building blocks — the hammers, chisels, bricks, and mortar — of the smartphone, the cloud, and the computing services on which we rely. Engineers and scientists need ever-more specialized computing tools to discover new material properties for manufacturing, make energy generation safer and more efficient, and provide insight into the fundamentals of the universe, for example. The research division of the U.S. Department of Energy’s (DOE’s) Office of Advanced Scientific Computing and Research (ASCR Research) ensures that these tools and building blocks are being developed and honed to meet the extreme needs of modern science. See also http://exascaleage.org/ascr/ for additional information.

  8. Proceedings of the Symposium on the Non-Proliferation Experiment: Results and Implications for Test Ban Treaties, Rockville, Maryland, April 19-21, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Denny, Marvin D

    1994-01-01

    To address a critical verification issue for the current Non-Proliferation Treaty (NPT) and for a possible future Comprehensive Test Ban Treaty (CTBT), the Department of Energy sought to measure certain differences between an underground nuclear test and a chemical test in the same geology, so that other explosions could be identified. This was done in a field experiment code-named the NonProliferation Experiment (NPE).This comprehensive experiment was designed to determine the signatures of chemical explosions for a broad range of phenomena for comparison with those of previous nuclear tests. If significant differences can be measured, then these measures can be used to discriminate between the two types of explosions. In addition, when these differences are understood, large chemical explosions can be used to seismically calibrate regions to discriminate earthquakes from explosions. Toward this end, on-site and off-site measurements of transient phenomena were made, and on-site measurements of residual effects are in progress.Perhaps the most striking result was that the source function for the chemical explosion was identical to that of a nuclear one of about twice the yield. These proceedings provide more detailed results of the experiment.

  9. Reproductive biology of the Cisalpine pike (Esox cisalpinus Bianco and Delmastro, 2011 in Trasimeno Lake (Italy.

    Directory of Open Access Journals (Sweden)

    Laura Pompei

    2015-11-01

    Total sample consisted of 292 females ranging in size from 28 to 103 cm (2+ -14+ age classes. Descriptive statistic of GSI, F, FR, δ and Wr is reported in Table 1. Fecundity was positively correlated with TL (r2=0.67, r=0.82, p0.05; covariate mean: TL=61.03 cm. On the contrary, RF varied remarkably from year to year (ANCOVA: F=3.57, p<0.05; covariate mean: TL=61.03 cm, without a clear temporal trend in the regression analysis (r2<0.01; r=-0.02; p=0.74. The great variability of RF values should be justified by the high unpredictability of environmental condition (i.e. water level, water temperature that characterize the Trasimeno Lake (Lorenzoni et al. 2002. The mean diameter of eggs showed a marked decrease from 2010 to 2012, with a slight increase in 2014 (ANCOVA: F=48.56, p<0.01; covariate mean: TL=61.03 cm; however the regression analysis highlights a general decrease over time (r2=0.03; r=-0.17, p<0.01 (Fig. 2A. A similar pattern was revealed from the regression between Wr and years (r2=0.02; r=-0.15, p<0.01 (Fig. 2B. In many fish species, egg size, which correlates with female size or condition, has been found to contribute to egg quality (Kamler, 1992. The reduction of the eggs diameter ultimately results in the quality of the offspring, since the amount and composition of the yolk have a great influence on the development of the larvae (Laine and Rajasilta, 1999. Condition of spawners is known to have significant effects on reproductive potential (Laine and Rajasilta, 1999, but it also influences the viability of eggs (Kjørsvik et al., 1990, thus the decrease in eggs size may be correlated to the worsening of condition during years that seems to affect E. cisalpinus in Trasimeno Lake. The worsening of both condition and quality of the eggs make necessary the continuation of the monitoring study to safeguard the conservation of the population. The preliminary results reported in this research increase the knowledge on the biological characteristic of E. cisalpinus and should assist decision-making in relation to the future management of this endemic species.

  10. Thermal tolerance of the invasive Belonesox belizanus, pike killifish, throughout ontogeny.

    Science.gov (United States)

    Kerfoot, James Roy

    2012-06-01

    The goal of this study was to characterize the variability of thermal tolerances between life-history stages of the invasive Belonesox belizanus and attempt to describe the most likely stage of dispersal across south Florida. In the laboratory, individuals were acclimated to three temperatures (20, 25, or 30°C). Upper and lower lethal thermal limits and temperatures at which feeding ceased were measured for neonates, juveniles, and adults. Thermal tolerance polygons were developed to represent the thermal tolerance range of each life-history stage. Results indicated that across acclimation temperatures upper lethal thermal limits were similar for all three stages (38°C). However, minimum lethal thermal limits were significantly different at the 30°C acclimation temperature, where juveniles (9°C) had an approximately 2.0°C and 4.0°C lower minimum lethal thermal limit compared with adults and neonates, respectively. According to thermal tolerance polygons, juveniles had an average tolerance polygonal area almost 20°C(2) larger than adults, indicating the greatest thermal tolerance of the three life-history stages. Variation in cessation of feeding temperatures indicated no significant difference between juveniles and adults. Overall, results of this study imply that juvenile B. belizanus may be equipped with the physiological flexibility to exercise habitat choice and reduce potential intraspecific competition with adults for limited food resources. Given its continued dispersal, the minimum thermal limit of juveniles may aid in continued dispersal of this species, especially during average winter temperatures throughout Florida where juveniles could act to preserve remnant populations until seasonal temperatures increase. © 2012 WILEY PERIODICALS, INC.

  11. A study of malignancy rates in different diagnostic categories of the Bethesda system for reporting thyroid cytopathology: An institutional experience

    Directory of Open Access Journals (Sweden)

    P. Arul

    2015-12-01

    Conclusion: Our study validated the efficacy of TBSRTC. In conclusion, the malignancy rate of AUS/FLUS in this study was higher than the risk mentioned in TBSRTC and other published studies. Hence, AUS/FLUS category patients in our setup warrant further workup including ultrasound and/or thyroid scan in addition to immediate repeat FNAC.

  12. MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria.

    Science.gov (United States)

    Crucianelli, Francesca; Tricarico, Rossella; Turchetti, Daniela; Gorelli, Greta; Gensini, Francesca; Sestini, Roberta; Giunti, Laura; Pedroni, Monica; Ponz de Leon, Maurizio; Civitelli, Serenella; Genuardi, Maurizio

    2014-10-01

    Lynch syndrome (LS) is a tumor predisposing condition caused by constitutional defects in genes coding for components of the mismatch repair (MMR) apparatus. While hypermethylation of the promoter of the MMR gene MLH1 occurs in about 15% of colorectal cancer samples, it has also been observed as a constitutional alteration, in the absence of DNA sequence mutations, in a small number of LS patients. In order to obtain further insights on the phenotypic characteristics of MLH1 epimutation carriers, we investigated the somatic and constitutional MLH1 methylation status of 14 unrelated subjects with a suspicion of LS who were negative for MMR gene constitutional mutations and whose tumors did not express the MLH1 protein. A novel case of constitutional MLH1 epimutation was identified. This patient was affected with multiple primary tumors, including breast cancer, diagnosed starting from the age of 55 y. Investigation of her offspring by allele specific expression revealed that the epimutation was not stable across generations. We also found MLH1 hypermethylation in cancer samples from 4 additional patients who did not have evidence of constitutional defects. These patients had some characteristics of LS, namely early age at onset and/or positive family history, raising the possibility of genetic influences in the establishment of somatic MLH1 methylation.

  13. A Study to Determine the Optimal Feasible Model for the Quality Assurance/Risk Management Program at Naval Hospital, Bethesda

    Science.gov (United States)

    1984-05-04

    Assurance. Within the last half of this century and especially since the advent of Medicare and Medicaid, a number of forces and trends have been...force in the quality assurance movement. They have been especially concerned about costs, allegations of excessive utilization of services and...ell as teintra- S;L.%.4ce accivities. At least a portion of continuing educacion of irsezvice tra~nn :)u~ e the result of probleI ident ificati on

  14. Proceedings of the Environmental Systems Symposium (13th) Held at Bethesda, Maryland on 20-22 March 1984.

    Science.gov (United States)

    1984-03-22

    shortfall in our early Installation Restoration program reports. For xe-lo, to say radioactive material is buried at a site, and not put in even the most...dont, but also for the very practical consequence of a aIn I polution - which becomes as positive a contribution to the whole effort whethe itbe a...sets en absolutet limitation on the quantity of seIfic pollutants pesemt ina the atoshre fer a region. The munt of polution allaweble irindividual

  15. 2017 Global Explosive Ordnance Disposal (EOD) Symposium and Exhibition. Held in North Bethesda, MD on 8-9 August 2017.

    Science.gov (United States)

    2017-08-09

    45 AM Keynote Address: Technology Innovation to Counter Improvised Threats and DTRA Integration Update • LTG Michael Shields, USA, Director...10:00 AM Networking Break EOD Silent Auction Opens Salons A-E 10:00 AM - 10:30 AM JIDO Technology Outreach Session: JIDO Overview and Counter...SYMPOSIUM & EXHIBITION AUGUST 7-9, 2017 AGENDA 10:30 AM - 11:15 AM EODWF State of the Foundation and Warrior Panel: Personal Stories of Growth

  16. Interaction of Drugs in the Hyperbaric Environment, Bethesda, Maryland, 13-14 September 1979. The Undersea Medical Workshop (21st),

    Science.gov (United States)

    1980-10-01

    activity. At the moment we would be hard- pressed to provide a definitive answer. 3. The use of "social" drugs such as alcohol or cannabis in con...innocuous drugs ASA, acetaminophen, caffeine , diphen- hydramine, dimenhydrinate, may cause significant decrements in perfor- mance at 3-7 ATA (10...pressure interactions, a few have indicated no changes in the hyperbaric envi- ronment. Animal evaluations of caffeine , theophylline, dimenhydrinate

  17. Basic Energy Sciences Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Basic Energy Sciences, November 3-5, 2015, Rockville, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Windus, Theresa [Ames Lab., Ames, IA (United States); Banda, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Devereaux, Thomas [SLAC National Accelerator Lab., Menlo Park, CA (United States); White, Julia C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Antypas, Katie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Coffey, Richard [Argonne National Lab. (ANL), Argonne, IL (United States); Dart, Eli [Energy Sciences Network (ESNet), Berkeley, CA (United States); Dosanjh, Sudip [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hack, James [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Monga, Inder [Energy Sciences Network (ESNet), Berkeley, CA (United States); Papka, Michael E. [Argonne National Lab. (ANL), Argonne, IL (United States); Riley, Katherine [Argonne National Lab. (ANL), Argonne, IL (United States); Rotman, Lauren [Energy Sciences Network (ESNet), Berkeley, CA (United States); Straatsma, Tjerk [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Jack [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Baruah, Tunna [Univ. of Texas, El Paso, TX (United States); Benali, Anouar [Argonne National Lab. (ANL), Argonne, IL (United States); Borland, Michael [Argonne National Lab. (ANL), Argonne, IL (United States); Brabec, Jiri [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Carter, Emily [Princeton Univ., NJ (United States); Ceperley, David [Univ. of Illinois, Urbana-Champaign, IL (United States); Chan, Maria [Argonne National Lab. (ANL), Argonne, IL (United States); Chelikowsky, James [Univ. of Texas, Austin, TX (United States); Chen, Jackie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Cheng, Hai-Ping [Univ. of Florida, Gainesville, FL (United States); Clark, Aurora [Washington State Univ., Pullman, WA (United States); Darancet, Pierre [Argonne National Lab. (ANL), Argonne, IL (United States); DeJong, Wibe [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Deslippe, Jack [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Dixon, David [Univ. of Alabama, Tuscaloosa, AL (United States); Donatelli, Jeffrey [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dunning, Thomas [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fernandez-Serra, Marivi [Stony Brook Univ., NY (United States); Freericks, James [Georgetown Univ., Washington, DC (United States); Gagliardi, Laura [Univ. of Minnesota, Minneapolis, MN (United States); Galli, Giulia [Univ. of Chicago, IL (United States); Garrett, Bruce [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Glezakou, Vassiliki-Alexandra [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gordon, Mark [Iowa State Univ., Ames, IA (United States); Govind, Niri [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gray, Stephen [Argonne National Lab. (ANL), Argonne, IL (United States); Gull, Emanuel [Univ. of Michigan, Ann Arbor, MI (United States); Gygi, Francois [Univ. of California, Davis, CA (United States); Hexemer, Alexander [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Isborn, Christine [Univ. of California, Merced, CA (United States); Jarrell, Mark [Louisiana State Univ., Baton Rouge, LA (United States); Kalia, Rajiv K. [Univ. of Southern California, Los Angeles, CA (United States); Kent, Paul [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Klippenstein, Stephen [Argonne National Lab. (ANL), Argonne, IL (United States); Kowalski, Karol [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Krishnamurthy, Hulikal [Indian Inst. of Science, Bangalore (India); Kumar, Dinesh [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lena, Charles [Univ. of Texas, Austin, TX (United States); Li, Xiaosong [Univ. of Washington, Seattle, WA (United States); Maier, Thomas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Markland, Thomas [Stanford Univ., CA (United States); McNulty, Ian [Argonne National Lab. (ANL), Argonne, IL (United States); Millis, Andrew [Columbia Univ., New York, NY (United States); Mundy, Chris [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Nakano, Aiichiro [Univ. of Southern California, Los Angeles, CA (United States); Niklasson, A.M.N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Panagiotopoulos, Thanos [Princeton Univ., NJ (United States); Pandolfi, Ron [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Parkinson, Dula [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pask, John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Perazzo, Amedeo [SLAC National Accelerator Lab., Menlo Park, CA (United States); Rehr, John [Univ. of Washington, Seattle, WA (United States); Rousseau, Roger [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sankaranarayanan, Subramanian [Argonne National Lab. (ANL), Argonne, IL (United States); Schenter, Greg [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Selloni, Annabella [Princeton Univ., NJ (United States); Sethian, Jamie [Univ. of California, Berkeley, CA (United States); Siepmann, Ilja [Univ. of Minnesota, Minneapolis, MN (United States); Slipchenko, Lyudmila [Purdue Univ., West Lafayette, IN (United States); Sternberg, Michael [Argonne National Lab. (ANL), Argonne, IL (United States); Stevens, Mark [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Summers, Michael [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sumpter, Bobby [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sushko, Peter [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Thayer, Jana [SLAC National Accelerator Lab., Menlo Park, CA (United States); Toby, Brian [Argonne National Lab. (ANL), Argonne, IL (United States); Tull, Craig [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Valeev, Edward [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Vashishta, Priya [Univ. of Southern California, Los Angeles, CA (United States); Venkatakrishnan, V. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yang, C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yang, Ping [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Zwart, Peter H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-02-03

    Computers have revolutionized every aspect of our lives. Yet in science, the most tantalizing applications of computing lie just beyond our reach. The current quest to build an exascale computer with one thousand times the capability of today’s fastest machines (and more than a million times that of a laptop) will take researchers over the next horizon. The field of materials, chemical reactions, and compounds is inherently complex. Imagine millions of new materials with new functionalities waiting to be discovered — while researchers also seek to extend those materials that are known to a dizzying number of new forms. We could translate massive amounts of data from high precision experiments into new understanding through data mining and analysis. We could have at our disposal the ability to predict the properties of these materials, to follow their transformations during reactions on an atom-by-atom basis, and to discover completely new chemical pathways or physical states of matter. Extending these predictions from the nanoscale to the mesoscale, from the ultrafast world of reactions to long-time simulations to predict the lifetime performance of materials, and to the discovery of new materials and processes will have a profound impact on energy technology. In addition, discovery of new materials is vital to move computing beyond Moore’s law. To realize this vision, more than hardware is needed. New algorithms to take advantage of the increase in computing power, new programming paradigms, and new ways of mining massive data sets are needed as well. This report summarizes the opportunities and the requisite computing ecosystem needed to realize the potential before us. In addition to pursuing new and more complete physical models and theoretical frameworks, this review found that the following broadly grouped areas relevant to the U.S. Department of Energy (DOE) Office of Advanced Scientific Computing Research (ASCR) would directly affect the Basic Energy Sciences (BES) mission need. Simulation, visualization, and data analysis are crucial for advances in energy science and technology. Revolutionary mathematical, software, and algorithm developments are required in all areas of BES science to take advantage of exascale computing architectures and to meet data analysis, management, and workflow needs. In partnership with ASCR, BES has an emerging and pressing need to develop new and disruptive capabilities in data science. More capable and larger high-performance computing (HPC) and data ecosystems are required to support priority research in BES. Continued success in BES research requires developing the next-generation workforce through education and training and by providing sustained career opportunities.

  18. Biological and Environmental Research Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Biological and Environmental Research, March 28-31, 2016, Rockville, Maryland

    Energy Technology Data Exchange (ETDEWEB)

    Arkin, Adam [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bader, David C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Coffey, Richard [Argonne National Lab. (ANL), Argonne, IL (United States); Antypas, Katie [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bard, Deborah [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). National Energy Research Scientific Computing Center (NERSC); Dart, Eli [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Esnet; Dosanjh, Sudip [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Gerber, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hack, James [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Monga, Inder [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Esnet; Papka, Michael E. [Argonne National Lab. (ANL), Argonne, IL (United States); Riley, Katherine [Argonne National Lab. (ANL), Argonne, IL (United States); Rotman, Lauren [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Esnet; Straatsma, Tjerk [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wells, Jack [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Aluru, Srinivas [Georgia Inst. of Technology, Atlanta, GA (United States); Andersen, Amity [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Aprá, Edoardo [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). EMSL; Azad, Ariful [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bates, Susan [National Center for Atmospheric Research, Boulder, CO (United States); Blaby, Ian [Brookhaven National Lab. (BNL), Upton, NY (United States); Blaby-Haas, Crysten [Brookhaven National Lab. (BNL), Upton, NY (United States); Bonneau, Rich [New York Univ. (NYU), NY (United States); Bowen, Ben [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bradford, Mark A. [Yale Univ., New Haven, CT (United States); Brodie, Eoin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Brown, James (Ben) [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Buluc, Aydin [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bernholdt, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bylaska, Eric [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Calvin, Kate [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cannon, Bill [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Chen, Xingyuan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Cheng, Xiaolin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cheung, Margaret [Univ. of Houston, Houston, TX (United States); Chowdhary, Kenny [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Colella, Phillip [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Collins, Bill [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Compo, Gil [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States); Crowley, Mike [National Renewable Energy Lab. (NREL), Golden, CO (United States); Debusschere, Bert [Sandia National Lab. (SNL-CA), Livermore, CA (United States); D’Imperio, Nicholas [Brookhaven National Lab. (BNL), Upton, NY (United States); Dror, Ron [Stanford Univ., Stanford, CA (United States); Egan, Rob [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Evans, Katherine [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Friedberg, Iddo [Iowa State Univ., Ames, IA (United States); Fyke, Jeremy [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gao, Zheng [Stony Brook Univ., Stony Brook, NY (United States); Georganas, Evangelos [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Giraldo, Frank [Naval Postgraduate School, Monterey, CA (United States); Gnanakaran, Gnana [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Govind, Niri [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). EMSL; Grandy, Stuart [Univ. of New Hampshire, Durham, NH (United States); Gustafson, Bill [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hammond, Glenn [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hargrove, William [USDA Forest Service, Washington, D.C. (United States); Heroux, Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hoffman, Forrest [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hofmeyr, Steven [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hunke, Elizabeth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jackson, Charles [Univ. of Texas-Austin, Austin, TX (United States); Jacob, Rob [Argonne National Lab. (ANL), Argonne, IL (United States); Jacobson, Dan [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jacobson, Matt [Univ. of California, San Francisco, CA (United States); Jain, Chirag [Georgia Inst. of Technology, Atlanta, GA (United States); Johansen, Hans [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Johnson, Jeff [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Jones, Andy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Jones, Phil [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kalyanaraman, Ananth [Washington State Univ., Pullman, WA (United States); Kang, Senghwa [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); King, Eric [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Koanantakool, Penporn [Univ. of California, Berkeley, CA (United States); Kollias, Pavlos [Stony Brook Univ., Stony Brook, NY (United States); Kopera, Michal [Univ. of California, Santa Cruz, CA (United States); Kotamarthi, Rao [Argonne National Lab. (ANL), Argonne, IL (United States); Kowalski, Karol [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). EMSL; Kumar, Jitendra [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kyrpides, Nikos [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Leung, Ruby [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Li, Xiaolin [Stony Brook Univ., Stony Brook, NY (United States); Lin, Wuyin [Brookhaven National Lab. (BNL), Upton, NY (United States); Link, Robert [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Liu, Yangang [Brookhaven National Lab. (BNL), Upton, NY (United States); Loew, Leslie [Univ. of Connecticut, Storrs, CT (United States); Luke, Edward [Brookhaven National Lab. (BNL), Upton, NY (United States); Ma, Hsi -Yen [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Mahadevan, Radhakrishnan [Univ. of Toronto, Toronto, ON (Canada); Maranas, Costas [Pennsylvania State Univ., University Park, PA (United States); Martin, Daniel [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Maslowski, Wieslaw [Naval Postgraduate School, Monterey, CA (United States); McCue, Lee Ann [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); McInnes, Lois Curfman [Argonne National Lab. (ANL), Argonne, IL (United States); Mills, Richard [Intel Corp., Santa Clara, CA (United States); Molins Rafa, Sergi [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Morozov, Dmitriy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Mostafavi, Sara [Center for Molecular Medicine and Therapeutics, Vancouver, BC (Canada); Moulton, David J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mourao, Zenaida [Univ. of Cambridge (United Kingdom); Najm, Habib [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Ng, Bernard [Center for Molecular Medicine and Therapeutics, Vancouver, BC (Canada); Ng, Esmond [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Norman, Matt [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Oh, Sang -Yun [Univ. of California, Santa Barbara, CA (United States); Oliker, Leonid [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pan, Chongle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pass, Rebecca [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Pau, George S. H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Petridis, Loukas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Prakash, Giri [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Price, Stephen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Randall, David [Colorado State Univ., Fort Collins, CO (United States); Renslow, Ryan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Riihimaki, Laura [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ringler, Todd [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Roberts, Andrew [Naval Postgraduate School, Monterey, CA (United States); Rokhsar, Dan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ruebel, Oliver [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Salinger, Andrew [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheibe, Tim [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Schulz, Roland [Intel, Mountain View, CA (United States); Sivaraman, Chitra [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Smith, Jeremy [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sreepathi, Sarat [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Steefel, Carl [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Talbot, Jenifer [Boston Univ., Boston, MA (United States); Tantillo, D. J. [Univ. of California, Davis, CA (United States); Tartakovsky, Alex [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Mark [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taylor, Ronald [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Trebotich, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Urban, Nathan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Valiev, Marat [Pacific Northwest National Lab. (PNNL), Richland, WA (United States). EMSL; Wagner, Allon [Univ. of California, Berkeley, CA (United States); Wainwright, Haruko [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wieder, Will [NCAR/Univ. of Colorado, Boulder, CO (United States); Wiley, Steven [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Williams, Dean [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Worley, Pat [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Xie, Shaocheng [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Yelick, Kathy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yoo, Shinjae [Brookhaven National Lab. (BNL), Upton, NY (United States); Yosef, Niri [Univ. of California, Berkeley, CA (United States); Zhang, Minghua [Stony Brook Univ., Stony Brook, NY (United States)

    2016-03-31

    Understanding the fundamentals of genomic systems or the processes governing impactful weather patterns are examples of the types of simulation and modeling performed on the most advanced computing resources in America. High-performance computing and computational science together provide a necessary platform for the mission science conducted by the Biological and Environmental Research (BER) office at the U.S. Department of Energy (DOE). This report reviews BER’s computing needs and their importance for solving some of the toughest problems in BER’s portfolio. BER’s impact on science has been transformative. Mapping the human genome, including the U.S.-supported international Human Genome Project that DOE began in 1987, initiated the era of modern biotechnology and genomics-based systems biology. And since the 1950s, BER has been a core contributor to atmospheric, environmental, and climate science research, beginning with atmospheric circulation studies that were the forerunners of modern Earth system models (ESMs) and by pioneering the implementation of climate codes onto high-performance computers. See http://exascaleage.org/ber/ for more information.

  19. Dietary LC-PUFA deficiency early in ontogeny induces behavioural changes in pike perch (Sander lucioperca) larvae and fry

    DEFF Research Database (Denmark)

    Lund, Ivar; Höglund, Erik; Ebbesson, Lars O.E.

    2014-01-01

    enriched with either refined olive oil high in oleic acid (A); refined olive oil supplemented with a low (B) or a high (C) level of DHA; or refined olive oil acid supplemented with fish oil with a high content of phospholipids (PL) and DHA (D). The enriched live diets were provided until 28days post hatch...... (dph), at which time larval behavioural responses to visual and mechano-sensory stimuli were assessed. All dietary groups were subsequently fed an identical enriched live feed (diet D) and gradually weaned to an extruded dry feed, on which they were maintained for 112days. At the end of this period...... that was not observed for larvae on diets low in DHA content. Independent of the predator simulation, larvae deficient or low in DHA exhibited significantly more time swimming along the edge of a test arena and had overall higher locomotor activities compared to larvae fed a diet with a high DHA content. Larvae on DHA...

  20. Brenda D. Phillips, Deborah S.K. Thomas, Alice Fothergill, Lynn Blinn‑Pike (orgs., Social Vulnerability to Disasters.

    Directory of Open Access Journals (Sweden)

    Susana Freiria

    2012-10-01

    Full Text Available Actualmente registam‑se em todo o mundo um número cada vez mais elevado de desastres e cujo impacto na vida das populações e nos seus bens é cada vez maior. Num cenário de catástrofe é importante conhecer os recursos humanos disponíveis, os cenários possíveis, os grupos mais vulneráveis em relação aos diversos perigos e quais as suas principais fragilidades. O livro Social Vulnerability to Disasters apresenta‑se como inovador na medida em que alia o conhecimento académico desenvolvido no âmb...

  1. 76 FR 71125 - Caddo Valley Railroad Company-Abandonment Exemption-in Clark, Pike, and Montgomery Counties, AR

    Science.gov (United States)

    2011-11-16

    ... Abandonments to abandon the portion of the Norman Branch Line extending between milepost 447, near Antoine, to... feeder line statute at 49 U.S.C. 10907. See Caddo Antoine & Little Mo. R.R.--Feeder Line Acquis.--Ark...

  2. 76 FR 71124 - Caddo Valley Railroad Company-Abandonment Exemption-in Pike and Clark Counties, AR

    Science.gov (United States)

    2011-11-16

    ... Branch Line extending between milepost 429.45, near Gurdon, and milepost 447, near Antoine, a distance of... AKMD under the Board's feeder line statute at 49 U.S.C. 10907. See Caddo Antoine & Little Mo. R.R...

  3. Extraction Optimization and Characterization of Collagen from Yellow Pike Conger Swimbladder with Acid-Hydro-Exctraction Method

    Directory of Open Access Journals (Sweden)

    Fernandy Djailani

    2016-08-01

    Full Text Available Swim bladder is one of marine potential byproducts for alternative source of collagen. This study aimedto optimize hydro-extraction and characterized collagen. Extraction optimization of collagen was determinedusing Box-behnken design response surface method with three variables: CH3COOH concentration, soakingtime and extraction time to yield response. Hydro-extraction collagen was characterization based on theamino acid content, SDS-PAGE, FT-IR and DSC. Acording to the result, the concentration had significantlyinfluence yield. Optimum extraction conditions were variable combinations of acetic acid concentration of0.1 M, for 1 h and hydro-extraction time of 1 h to produce the highest yield 63.35%. collagen was classifiedas type I collagen by amino acid content, electrophoresis patterns and fourier transform infrared (FTIRspectra. The glass transition of collagen was 67.23oC, showed high thermal stability that can be applied tothe cosmetics industry and nutraceutical.

  4. Assessing effectiveness of electrical stunning and chillingin ice water of farmed yellowtail kingfish, common sole and pike-perch

    NARCIS (Netherlands)

    Llonch, P.; Lambooij, E.; Reimert, H.G.M.; Vis, van de J.W.

    2012-01-01

    Animals should be rendered unconscious before slaughter in order to avoid suffering or pain. The objective of this study was to evaluate an electrical stunning after dewatering to induce instantaneous unconsciousness and insensibility in yellowtail kingfish (Seriola lalandi), common sole (Solea

  5. Microsatellite instability analysis in hereditary non-polyposis colon cancer using the Bethesda consensus panel of microsatellite markers in the absence of proband normal tissue

    Directory of Open Access Journals (Sweden)

    Dourisboure Ricardo J

    2006-01-01

    Full Text Available Abstract Background Hereditary non-polyposis colon cancer (HNPCC is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1. In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters of a male who died of colorectal adenocarcinoma at the age of 23. The family fulfilled strict Amsterdam-I criteria (AC-I with the presence of extracolonic tumors in the extended pedigree. We overcame the difficulty of having a proband post-mortem non-tumor tissue sample for MSI testing by studying the alleles carried by his progenitors. Methods Tumor MSI testing is described as initial screening in both primary and metastasis tumor tissue blocks, using the reference panel of 5 microsatellite markers standardized by the National Cancer Institute (NCI for the screening of HNPCC (BAT-25, BAT-26, D2S123, D5S346 and D17S250. Subsequent mutation analysis of the hMLH1 and hMSH2 genes was performed. Results Three of five microsatellite markers (BAT-25, BAT-26 and D5S346 presented different alleles in the proband's tumor as compared to those inherited from his parents. The tumor was classified as high frequency microsatellite instability (MSI-H. We identified in the HNPCC family a novel germline missense (c.1864C>A mutation in exon 12 of hMSH2 gene, leading to a proline 622 to threonine (p.Pro622Thr amino acid substitution. Conclusion This approach allowed us to establish the tumor MSI status using the NCI recommended panel in the absence of proband's non-tumor tissue and before sequencing the obligate carrier. According to the Human Gene Mutation Database (HGMD and the International Society for Gastrointestinal Hereditary Tumors (InSiGHT Database this is the first report of this mutation.

  6. Proceedings of the Symposium on Fluid-Solid Surface Intractions (2nd) Held at the Naval Ship Research and Development Center, Bethesda, Maryland, June 5-7, 1974,

    Science.gov (United States)

    1974-11-29

    sponsored by the German Ministry of Defense and organized by Dornier System, GmbH, Friedrichshafen . The encouraging results of the Meersburg meeting...Republic of Germany BHrwinkel, K. Dornier System GmbH, 799 Friedrichshafen , Rieger, H. Federal Republic of Germany Seidl, M. Bossel, U.G. Deutsche...Technological Importance of Gas-Solid Surface Interactions G. Hoff Dornier System GmbH 799 Friedrichshafen , Germany Any reasonable investigation of the

  7. Developing a Novel Eye Tracking Paradigm to Assess Mild Traumatic Brain Injury: A Feasibility Study of the Bethesda Eye and Attention Measure (BEAM)

    Science.gov (United States)

    2012-10-01

    alerting, executive, and gap networks (Fan, et al., 2008; Fan, et al., 2005; Fan, et al., 2002; Fan & Posner, 2004; Fernandez- Duque & Posner, 2001... Duque , D., & Posner, M. I. (2001). Brain imaging of attentional networks in normal and pathological states. Journal of Clinical and Experimental

  8. Stability Analysis of Finite Difference Approximations to Hyperbolic Systems, and Problems in Applied and Computational Matrix Theory

    Science.gov (United States)

    1988-07-08

    Marcus and C. Baczynski), Computer Science Press, Rockville, Maryland, 1986. 3. An Introduction to Pascal and Precalculus , Computer Science Press...Science Press, Rockville, Maryland, 1986. 35. An Introduction to Pascal and Precalculus , Computer Science Press, Rockville, Maryland, 1986. 36

  9. 75 FR 1399 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-01-11

    ... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person... Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Syed M... a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M...

  10. 77 FR 63842 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-17

    ... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD....m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  11. Social learning in a high-risk environment: incomplete disregard for the 'minnow that cried pike' results in culturally transmitted neophobia.

    Science.gov (United States)

    Crane, Adam L; Mathiron, Anthony G E; Ferrari, Maud C O

    2015-08-07

    Many prey species rely on conspecifics to gather information about unknown predation threats, but little is known about the role of varying environmental conditions on the efficacy of social learning. We examined predator-naive minnows that had the opportunity to learn about predators from experienced models that were raised in either a low- or high-risk environment. There were striking differences in behaviour among models; high-risk models showed a weaker response to the predator cue and became neophobic in response to the control cue (a novel odour, NO). Observers that were previously paired with low-risk models acquired a strong antipredator response only to the predator cue. However, observers that interacted with high-risk models, displayed a much weaker response to the predator odour and a weak neophobic response to the NO. This is the first study reporting such different outcomes of social learning under different environmental conditions, and suggests high-risk environments promote the cultural transmission of neophobia more so than social learning. If such a transfer can be considered similar to secondary traumatization in humans, culturally transmitted neophobia in minnows may provide a good model system for understanding more about the social ecology of fear disorders. © 2015 The Author(s).

  12. Higher-order organisation of extremely amplified, potentially functional and massively methylated 5S rDNA in European pikes (Esox sp.)

    Czech Academy of Sciences Publication Activity Database

    Symonová, R.; Ocalewicz, K.; Kirtiklis, L.; Delmastro, G. B.; Pelikánová, Šárka; Garcia, S.; Kovařík, Aleš

    2017-01-01

    Roč. 18, č. 391 (2017), č. článku 391. ISSN 1471-2164 R&D Projects: GA ČR GA14-02940S; GA ČR GBP501/12/G090 Institutional support: RVO:67985904 ; RVO:68081707 Keywords : rDNA * evolution * chromosome Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Genetics and heredity (medical genetics to be 3) Impact factor: 3.729, year: 2016

  13. Integrating pixel- and polygon-based approaches to wildfire risk assessment: Application to a high-value watershed on the Pike and San Isabel National Forests, Colorado, USA

    Science.gov (United States)

    Matthew P. Thompson; Julie W. Gilbertson-Day; Joe H. Scott

    2015-01-01

    We develop a novel risk assessment approach that integrates complementary, yet distinct, spatial modeling approaches currently used in wildfire risk assessment. Motivation for this work stems largely from limitations of existing stochastic wildfire simulation systems, which can generate pixel-based outputs of fire behavior as well as polygon-based outputs of simulated...

  14. Reservoir characterization and final pre-test analysis in support of the compressed-air-energy-storage Pittsfield aquifer field test in Pike County, Illinois

    Energy Technology Data Exchange (ETDEWEB)

    Wiles, L.E.; McCann, R.A.

    1983-06-01

    The work reported is part of a field experimental program to demonstrate and evaluate compressed air energy storage in a porous media aquifer reservoir near Pittsfield, Illinois. The reservoir is described. Numerical modeling of the reservoir was performed concurrently with site development. The numerical models were applied to predict the thermohydraulic performance of the porous media reservoir. This reservoir characterization and pre-test analysis made use of evaluation of bubble development, water coning, thermal development, and near-wellbore desaturation. The work was undertaken to define the time required to develop an air storage bubble of adequate size, to assess the specification of instrumentation and above-ground equipment, and to develop and evaluate operational strategies for air cycling. A parametric analysis was performed for the field test reservoir. (LEW)

  15. 77 FR 59934 - National Center for Advancing Translational Sciences; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-01

    .... to 3:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Washington DC/Rockville...:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Rockville, 1750 Rockville.... Time: 8:00 a.m. to 5:00 p.m. Agenda: To review and evaluate grant applications. Place: Hilton Rockville...

  16. Use of Circadian Lighting System to improve night shift alertness and performance of NRC Headquarters Operations Officers

    Energy Technology Data Exchange (ETDEWEB)

    Baker, T.L.; Morisseau, D.; Murphy, N.M. [ShiftWork Systems, Cambridge, MA (United States)] [and others

    1995-04-01

    The Nuclear Regulatory Commission`s (NRC) Headquarters Operations Officers (HOOs) receive and respond to events reported in the nuclear industry on a 24-hour basis. The HOOs have reported reduced alertness on the night shift, leading to a potential deterioration in their on-shift cognitive performance during the early morning hours. For some HOOs, maladaptation to the night shift was also reported to be the principal cause of: (a) reduced alertness during the commute to and from work, (b) poor sleep quality, and (c) personal lifestyle problems. ShiftWork Systems, Inc. (SWS) designed and installed a Circadian Lighting System (CLS) at both the Bethesda and Rockville HOO stations with the goal of facilitating the HOOs physiological adjustment to their night shift schedules. The data indicate the following findings: less subjective fatigue on night shifts; improved night shift alertness and mental performance; higher HOO confidence in their ability to assess event reports; longer, deeper and more restorative day sleep after night duty shifts; swifter adaptation to night work; and a safer commute, particularly for those with extensive drives.

  17. Use of Circadian Lighting System to improve night shift alertness and performance of NRC Headquarters Operations Officers

    International Nuclear Information System (INIS)

    Baker, T.L.; Morisseau, D.; Murphy, N.M.

    1995-01-01

    The Nuclear Regulatory Commission's (NRC) Headquarters Operations Officers (HOOs) receive and respond to events reported in the nuclear industry on a 24-hour basis. The HOOs have reported reduced alertness on the night shift, leading to a potential deterioration in their on-shift cognitive performance during the early morning hours. For some HOOs, maladaptation to the night shift was also reported to be the principal cause of: (a) reduced alertness during the commute to and from work, (b) poor sleep quality, and (c) personal lifestyle problems. ShiftWork Systems, Inc. (SWS) designed and installed a Circadian Lighting System (CLS) at both the Bethesda and Rockville HOO stations with the goal of facilitating the HOOs physiological adjustment to their night shift schedules. The data indicate the following findings: less subjective fatigue on night shifts; improved night shift alertness and mental performance; higher HOO confidence in their ability to assess event reports; longer, deeper and more restorative day sleep after night duty shifts; swifter adaptation to night work; and a safer commute, particularly for those with extensive drives

  18. 76 FR 55076 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2011-09-06

    ... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, Bethesda, MD 20814. Contact Person... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC...

  19. 77 FR 35417 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-13

    .... Place: St. Gregory Hotel, 2033 M Street NW., Washington, DC 20036. Contact Person: Geoffrey G Schofield... applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD...

  20. 77 FR 58852 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-09-24

    ...: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M... Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  1. Using Medicaid To Increase Funding for Home- and Community-Based Mental Health Services for Children and Youth with Severe Emotional Disturbances. A Report on a CASSP Workshop (Bethesda, Maryland, September 14-15, 1988).

    Science.gov (United States)

    Williams, Sarah

    This report highlights the major issues discussed during a 2-day workshop on Medicaid funding for community-based mental health services for children and youth with severe emotional disturbances. The report opens with a brief description of the service needs of children and youth with severe emotional disturbances and the system of care that can…

  2. Proceedings of the Ship Control Systems Symposium (9th) Held in Bethesda, Maryland on 10-14 September 1990. Theme: Automation in Surface Ship Control Systems, Today’s Applications and Future Trends. Volume 1

    Science.gov (United States)

    1990-09-14

    8217 training, and discuss ’the climate for similar advances in the near and long term. 2. INTRODUCTION For the first half of this century, marine plant...5. THE CLIMATE FOR IMCS ADVANCEMENT Over the next decade, the greatest attention will be paid to the in-service aspects of IMCS. The tasks of...HYDRAULIC FLAT BELT (STEEL REINFORCE[)) I•V MOVING WE4ýIGHGT AULIC BUFFER UNIT UNIT Figure 2 - Hull Section - Moving Weight Instillation Vith a

  3. The Pathophysiology of Combined Injury and Trauma: Proceedings of the International Symposium (1st) Held at the Uniformed Services University of the Health Sciences, Bethesda, Maryland on 27-29 April 1983

    Science.gov (United States)

    1983-04-29

    theraoy . The present studies have focused on a -2 220 -Iclinically relevant model of immunosuppression, thermal injury, in examining the therapeutic...North Amer. 58:1291. 3. Pruitt, B.A., Jr. (1978) Advances in fluid theraoy and the early care of the burn patient. World j. Surg. 2:139. 4. Baxter, C.R...1983) Plasmapheresis in clinical medicine. West. J. Med. 138:60. ?9. Pinchina, A.J. (1979) Pecent advances in inmunolnqical theraoy : Plasm3 exchange and

  4. Proceedings of the Ship Control Systems Symposium (9th) Held in Bethesda, Maryland on 10-14 September 1990. Theme: Automation in Surface Ship Control Systems, Today’s Applications and Future Trends. Volume 4

    Science.gov (United States)

    1990-09-14

    and can be fused separately. The RTU’s low-power consumption makes them ideally suited for battery and solar powered applications. 3.5 Redundant...dei movimenti e delle sollecitazioni di una nave in mare tempestoso per mezzo del metodo dello spettro di energia e della teoria della

  5. Proceedings of the International Conference on Cyclic Nucleotides, Calcium and Protein Phosphorylation (6th) Held in Bethesda, Maryland on September 2-7, 1986. Advances in Second Messenger and Phosphorprotein Research. Volume 21A. Abstracts Volume

    Science.gov (United States)

    1988-11-16

    on an operational classification (Robinson- Steiner , A.M., Beebe, S.J., Rannels, S.R., and Corbin, J.D. (1984) J. Biol. Chem. 259, 10595). RIIA forms... Rudolf -Bucheim-Institut flir Phariakologie, D-6300 Giessen, F.R.G. Botulimnm C2 tocin (BtcxC2), which causes hypotnic effects, increase in vascular

  6. 75 FR 21005 - National Advisory Council on the National Health Service Corps; Notice of Meeting

    Science.gov (United States)

    2010-04-22

    ... (BCRS), discuss recruitment and marketing strategies for the NHSC, and address current workforce issues.... Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852, Phone...

  7. 75 FR 33627 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-06-14

    ... review and evaluate grant applications. Place: St. Gregory Hotel, 2033 M Street, NW., Washington, DC... grant applications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue...

  8. 75 FR 80826 - Compliance Policy Guide Sec. 527.300 Dairy Products-Microbial Contaminants and Alkaline...

    Science.gov (United States)

    2010-12-23

    ... Lane, Rockville, MD 20857. Send two self-addressed adhesive labels to assist that office in processing... Fishers Lane, Rm. 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Monica Metz, Center for Food...

  9. 77 FR 4023 - Sunshine Act Meeting Notice

    Science.gov (United States)

    2012-01-26

    ...: Hearing Room 420, Bethesda Towers, 4330 East West Highway, Bethesda, Maryland. STATUS: Closed to the..., 2012, 9 a.m.-12 p.m. PLACE: Room 420, Bethesda Towers, 4330 East West Highway, Bethesda, Maryland... Swings--Notice of Proposed Rulemaking. 2. Briefing Matter: ASTM F'963 '11. A live webcast of the Meeting...

  10. 76 FR 27069 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2011-05-10

    ... Interactions. Place: Double Tree by Hilton Hotel Bethesda, The Grand Ball Room, 8120 Wisconsin Avenue, Bethesda... show one form of identification (for example, a government-issued photo ID, driver's license, or...

  11. 77 FR 5259 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-02

    .... Place: Bethesda North Marriott & Conference Center, 5701 Marinelli Road, North Bethesda, MD 20852...:30 p.m. Agenda: To review and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali...

  12. Clinical Trials

    Medline Plus

    Full Text Available ... studies. View funding information for clinical trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn ... and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn ...

  13. Iron-Deficiency Anemia

    Medline Plus

    Full Text Available ... Iron-Deficiency Anemia (National Library of Medicine, MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn ... and Usage No FEAR Act Grants and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn ...

  14. 77 FR 2073 - Center for Scientific Review Notice of Closed Meetings

    Science.gov (United States)

    2012-01-13

    ... 2--Translational Clinical Integrated Review Group; Basic Mechanisms of Cancer Therapeutics Study... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Fouad A El-Zaatari, Ph.D...

  15. 77 FR 485 - Fusion Energy Sciences Advisory Committee

    Science.gov (United States)

    2012-01-05

    ...: Doubletree Bethesda Hotel and Executive Meeting Center, 8120 Wisconsin Avenue Bethesda, Maryland 20814. FOR... Congressional Budget Request. FES perspective and FY 2013 Congressional Budget Request for FES. Briefing on the...

  16. Clinical Trials

    Medline Plus

    Full Text Available ... trials optimization . Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Get ... and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Connect ...

  17. Iron-Deficiency Anemia

    Medline Plus

    Full Text Available ... Medicine, MedlinePlus) Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Get ... and Funding Building 31 31 Center Drive Bethesda, MD 20892 Learn more about getting to NIH Connect ...

  18. 78 FR 15020 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Science.gov (United States)

    2013-03-08

    ... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: John J. Laffan, Ph.D..., and Biological Chemistry Research; 93.862, Genetics and Developmental Biology Research; 93.88...

  19. 77 FR 17478 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2012-03-26

    ... Maryland, Rockville, Maryland. B. Federal Reserve Bank of Minneapolis (Jacqueline G. King, Community... Russell Bauman, both of Kerkhoven, Minnesota, as individuals and members of the Bauman Family Control...

  20. 76 FR 7571 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-10

    ..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call). Contact Person....: 93.279, Drug Abuse and Addiction Research Programs, National Institutes of Health, HHS) Dated...

  1. 76 FR 15329 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-03-21

    .... Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852... of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs...

  2. 76 FR 78672 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-12-19

    ..., Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person... Addiction Research Programs, National Institutes of Health, HHS) Dated: December 13, 2011. Jennifer S...

  3. 77 FR 35418 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-13

    ... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call... of Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs...

  4. 21 CFR 1002.20 - Reporting of accidental radiation occurrences.

    Science.gov (United States)

    2010-04-01

    ...: Accidental Radiation Occurrence Reports (HFZ-240), Office of Communication, Education, and Radiation Programs, 9200 Corporate Blvd., Rockville, MD 20850, and the reports and their envelopes shall be distinctly...

  5. 77 FR 12603 - National Institute of Mental Health; Notice of Closed Meeting

    Science.gov (United States)

    2012-03-01

    ... Health; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory Committee Act, as...: Doubletree Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: March 14, 2012, 8:30 a.m. to 12... meet with PIs Training Fellows and Staff Scientists. Place: Doubletree Hotel Bethesda, 8120 Wisconsin...

  6. 75 FR 53320 - National Institute of Mental Health; Notice of Closed Meetings

    Science.gov (United States)

    2010-08-31

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute of Mental...: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person... of Mental Health, National Institutes of Health, 6001 Executive Blvd., Room 6154, MSC 9609, Bethesda...

  7. 77 FR 68136 - National Cancer Institute Amended; Notice of Meeting

    Science.gov (United States)

    2012-11-15

    ... Regency Bethesda Hotel, Old Georgetown Room, One Metro Center, Bethesda, MD 20814. The NCAB ad hoc... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute..., Building 31C, Wing C, Conference Room 10, 31 Center Drive, Bethesda, MD 20892 which was published in the...

  8. 78 FR 5191 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2013-01-24

    ... review and evaluate grant applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue.... to 2:00 p.m. Agenda: To review and evaluate grant applications. Place: DoubleTree by Hilton Hotel... applications. Place: DoubleTree by Hilton Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact...

  9. 77 FR 37425 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-21

    ...: St. Gregory Hotel, 2033 M Street NW., Washington, DC 20036. Contact Person: Mark P Rubert, Ph.D.... Place: Hyatt Regency Bethesda, One Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814... p.m. Agenda: To review and evaluate grant applications. Place: St Gregory Hotel, 2033 M Street...

  10. Women: A Developmental Perspective. Proceedings of a Research Conference Sponsored by the National Institute of Child Health and Human Development in Cooperation with the National Institute of Mental Health and the National Institute on Aging (Bethesda, Maryland, November 20-21, 1980).

    Science.gov (United States)

    Berman, Phyllis W., Ed.; Ramey, Estelle R., Ed.

    These proceedings consist of 26 papers delivered at a conference devoted to research on the health and development of women. The focus of the conference was on women's health concerns, female development from infancy to womanhood, women and work, reproduction and giving birth, women and the family, sexuality, and the middle and later years.…

  11. 77 FR 16315 - Indiana Disaster #IN-00041

    Science.gov (United States)

    2012-03-20

    ..., Harrison, Jackson, Jennings, Lawrence, Ohio, Orange, Pike, Spencer, Switzerland, Vanderburgh. Kentucky: Carroll, Daviess, Henderson, Jefferson, Oldham, Trimble. The Interest Rates are: Percent For Physical...

  12. 76 FR 62810 - Agency Information Collection Activities; Submission for Office of Management and Budget Review...

    Science.gov (United States)

    2011-10-11

    ... Management, Food and Drug Administration, 1350 Piccard Dr., PI50-400B, Rockville, MD 20850, 301-796-3793... management role during and following a food recall. Risk management involves communicating both with industry... Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852, and may...

  13. 75 FR 76474 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2010-12-08

    ..., Validating, Refining Tools for Ecologic Momentary Assessment. Date: January 6, 2011. Time: 10 a.m. to 12 p.m... Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone Conference Call). Contact Person... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852. (Telephone...

  14. 75 FR 70304 - Advisory Committee on Reactor Safeguards

    Science.gov (United States)

    2010-11-17

    ..., Rockville, Maryland. Thursday, December 2, 2010, Conference Room T2-B1, Two White Flint North, Rockville... opening remarks regarding the conduct of the meeting. 8:35 a.m.-10 a.m.: Final Safety Evaluation Report... Kewaunee, Inc., regarding the final safety evaluation report associated with the License Renewal...

  15. 75 FR 29769 - Notice of Meetings

    Science.gov (United States)

    2010-05-27

    ... above-cited statutes. 1. Name of Subcommittee: Health Care Technology and Decision Sciences. Date: June...: Crowne Plaza Hotel, 3 Research Court, Conference Room TBD, Rockville, MD 20852. 2. Name of Subcommittee... remainder of the meeting) Place: Sheraton Rockville Hotel, 920 King Farm Boulevard, Conference Room TBD...

  16. Validation of a patient interview for assessing reasons for antipsychotic discontinuation and continuation

    Directory of Open Access Journals (Sweden)

    Matza LS

    2012-07-01

    Full Text Available Louis S Matza,1 Glenn A Phillips,2 Dennis A Revicki,1 Haya Ascher-Svanum,3 Karen G Malley,4 Andrew C Palsgrove,1 Douglas E Faries,3 Virginia Stauffer,3 Bruce J Kinon,3 A George Awad,5 Richard SE Keefe,6 Dieter Naber71Outcomes Research, United BioSource Corporation, Bethesda, MD, 2Formerly with Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly and Company, Indianapolis, IN, 4Malley Research Programming, Inc, Rockville, MD, USA; 5Department of Psychiatry and Behavioral Sciences; University of Toronto, Toronto, Canada; 6Duke University Medical Center, Durham NC, USA; 7Universitaetsklinikum Hamburg-Eppendorf, Hamburg, GermanyIntroduction: The Reasons for Antipsychotic Discontinuation Interview (RAD-I was developed to assess patients’ perceptions of reasons for discontinuing or continuing an antipsychotic. The current study examined reliability and validity of domain scores representing three factors contributing to these treatment decisions: treatment benefits, adverse events, and distal reasons other than direct effects of the medication.Methods: Data were collected from patients with schizophrenia or schizoaffective disorder and their treating clinicians. For approximately 25% of patients, a second rater completed the RAD-I for assessment of inter-rater reliability.Results: All patients (n = 121; 81 discontinuation, 40 continuation reported at least one reason for discontinuation or continuation (mean = 2.8 reasons for discontinuation; 3.4 for continuation. Inter-rater reliability was supported (kappas = 0.63–1.0. Validity of the discontinuation domain scores was supported by associations with symptom measures (the Positive and Negative Syndrome Scale for Schizophrenia, the Clinical Global Impression – Schizophrenia Scale; r = 0.30 to 0.51; all P < 0.01, patients’ primary reasons for discontinuation, and adverse events. However, the continuation domain scores were not significantly associated with these other indicators

  17. New species of Braggia (Hemiptera: Aphididae) on buckwheat in western North America

    Science.gov (United States)

    K. S. Pike; G. Graf; R. G. Foottit; H. E. L. Maw; P. Stary; R. Hammon; D. G. Miller

    2009-01-01

    Species of Braggia Gillette and Palmer (Hemiptera: Aphididae: Aphidinae: Aphidini) feed on various buckwheat, Eriogonum Michx. (Polygonaceae), species in western North America. Two new species, Braggia columbiana Pike n. sp. from Washington and Oregon and Braggia longicauda Pike n. sp. from Washington, Oregon, and northern California, are proposed. Descriptions,...

  18. God ot goda populjarneje / Aadu Kana

    Index Scriptorium Estoniae

    Kana, Aadu

    2005-01-01

    Parima betoonehitise konkursist. Aasta betoonehitis 2004 - Ülemiste hotell, arhitekt Martin Aunin, projekteerija AS EA Reng, konstruktsioonid: IB Pike, ehitaja AS FKSM, betoon: AS HC Betoon. Eeriauhinnad: Rakvere spordihalli ja Veskimöldre lasteaia betoonelementide tootja E-Betoonelement, IB Pike ja Tiit Masso City Plaza konstruktsioonide eest, Kakumäel asuva eramu tellija ja sisekujundaja Raina Lillepõld

  19. Messages of invasive Perccottus glenii individuals eaten by an Esox lucius from the Danube Delta

    OpenAIRE

    Ilie Cătălin Telcean; Alfred-Stefan Cicort-Lucaciu

    2016-01-01

    In the stomach of a pike from the Danube Delta we have found seven Perccottus glenii individuals. Their message indicated that in the Danube Delta P. glenii has already large population. Also, it proves that in its habitats, the pike can consume numerous individuals of this invasive species. Their gut contents prove that P. glenii hunted near the shores, ingesting numerous terrestrial preys.

  20. Metropolitan Spokane Region Water Resources Study. Appendix E. Environment and Recreation

    Science.gov (United States)

    1976-01-01

    at Porcupine Bay, maintains a small but productive fishery for walleye pike and large mouth bass. The principal fishery is for walleye pike which takes...elevations. The whitetail deer of the Spokane area are part of the Coeur d’Alene herd . They favor the lower elevations and adapt very well to the river

  1. Airway Clearance Techniques (ACTs)

    Medline Plus

    Full Text Available ... Autogenic Drainage Positive Expiratory Pressure High-Frequency Chest Wall Oscillation (the Vest) ... Cystic Fibrosis Foundation 4550 Montgomery Ave. Suite 1100 N Bethesda, MD ...

  2. 78 FR 50426 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2013-08-19

    ... secrets or commercial property such as patentable material, and personal information concerning.... Place: NIH Building 60 (The Cloister), 1 Cloister Court (Center Drive and Convent Drive), Bethesda, MD...

  3. 77 FR 28886 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-05-16

    ... Health, 6701 Rockledge Drive, Bethesda, MD 20892 (Telephone Conference Call). Contact Person: Stephen M... review and evaluate grant applications. Place: Hotel Monaco Alexandria, 480 King Street, Alexandria, VA...

  4. 77 FR 22361 - Entergy Nuclear Operations, Inc., (Indian Point Nuclear Generating Units 2 and 3); Notice of...

    Science.gov (United States)

    2012-04-13

    ... NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 9th day of April 2012. E. Roy Hawkens, Chief Administrative Judge, Atomic Safety and Licensing Board Panel. [FR Doc. 2012...

  5. 77 FR 71454 - Notice of Atomic Safety And Licensing Board Reconstitution, Tennessee Valley Authority (Watts Bar...

    Science.gov (United States)

    2012-11-30

    ... accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland this 16th day of November 2012. E. Roy Hawkens, Chief Administrative Judge, Atomic Safety and Licensing Board Panel...

  6. 75 FR 52996 - Areva Enrichment Services, LLC (Eagle Rock Enrichment Facility); Notice of Atomic Safety and...

    Science.gov (United States)

    2010-08-30

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 24th day of August 2010. E. Roy...

  7. 78 FR 56944 - Strata Energy, Inc. (Ross In Situ Recovery Uranium Project); Notice of Atomic Safety and...

    Science.gov (United States)

    2013-09-16

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland this 10th day of September 2013. E. Roy...

  8. 77 FR 65417 - Northern States Power Company (Prairie Island Nuclear Generating Plant Independent Spent Fuel...

    Science.gov (United States)

    2012-10-26

    ..., documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, October 22, 2012. E. Roy Hawkens, Chief...

  9. 76 FR 78702 - Progress Energy Florida, Inc. (Combined License Application for Levy County Nuclear Power Plant...

    Science.gov (United States)

    2011-12-19

    ... correspondence, documents, and other materials shall continue to be filed in accordance with the NRC E-Filing rule. See 10 CFR 2.302 et seq. Issued at Rockville, Maryland, this 13th day of December 2011. E. Roy...

  10. 78 FR 11660 - Eunice Kennedy Shriver National Institute of Child Health & Human Development; Notice of Closed...

    Science.gov (United States)

    2013-02-19

    ... Prevention of Cardiovascular Birth Defects. Date: March 12, 2013. Time: 2:00 p.m. to 4:00 p.m. Agenda: To... Boulevard, Rockville, MD 20852 (Telephone Conference Call). Contact Person: Peter Zelazowski, Ph.D...

  11. 76 FR 76169 - Eunice Kennedy Shriver National Institute of Child Health & Human Development Notice of Meeting

    Science.gov (United States)

    2011-12-06

    .... Date: December 14, 2011. Time: 1 p.m. to 5 p.m. Agenda: To provide concept review of proposed concept review. Place: National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852 (Telephone...

  12. 75 FR 61501 - Cooperative Agreement To Support Capacity Building Activities Through the World Health...

    Science.gov (United States)

    2010-10-05

    ... REQUIREMENTS CONTACT: Program Contact: Patrick McDermott, Division of Animal and Food Microbiology, Center for Veterinary Medicine, Food and Drug Administration, 7519 Standish Pl., Mod II, rm. 1505, Rockville, MD 20855...

  13. PROCEEDINGS OF THE INTERNATIONAL WORKSHOP ON UNCERTAINTY, SENSITIVITY, AND PARAMETER ESTIMATION FOR MULTIMEDIA ENVIRONMENTAL MODELING. EPA/600/R-04/117, NUREG/CP-0187, ERDC SR-04-2.

    Science.gov (United States)

    An International Workshop on Uncertainty, Sensitivity, and Parameter Estimation for Multimedia Environmental Modeling was held August 1921, 2003, at the U.S. Nuclear Regulatory Commission Headquarters in Rockville, Maryland, USA. The workshop was organized and convened by the Fe...

  14. 77 FR 62243 - Health Resources and Services Administration

    Science.gov (United States)

    2012-10-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Health Resources and Services Administration National... Services Administration (HRSA), Parklawn Building (and via audio conference call), 5600 Fishers Lane, Room... and Services Administration, Parklawn Building, Room 13-64, 5600 Fishers Lane, Rockville, Maryland...

  15. Ideas and Inspirations: Good News about Diabetes Prevention and Management in Indian Country

    Medline Plus

    Full Text Available ... Lane, Rockville, MD 20857 - Find a Mail Stop Office Mail Stops Office of Clinical and Preventive Services - 08N34 A&B Office of the Director - 08E37A Office of the Director/ ...

  16. Talking to Your Doctor

    Science.gov (United States)

    ... and Notices Freedom of Information Act No Fear Act Office of Inspector General USA.gov – Government Made Easy NIH…Turning Discovery Into Health ® National Institutes of Health, 9000 Rockville ...

  17. Researcher Story: Stuttering

    Medline Plus

    Full Text Available ... and Notices Freedom of Information Act No Fear Act Office of Inspector General USA.gov – Government Made Easy NIH…Turning Discovery Into Health ® National Institutes of Health, 9000 Rockville ...

  18. Talking to Your Doctor

    Medline Plus

    Full Text Available ... and Notices Freedom of Information Act No Fear Act Office of Inspector General USA.gov – Government Made Easy NIH…Turning Discovery Into Health ® National Institutes of Health, 9000 Rockville ...

  19. PRESSURE - WATER and Other Data from NOAA Ship McARTHUR From Coastal Waters of Washington/Oregon from 1982-05-25 to 1982-07-21 (NODC Accession 8600236)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This entry contains CTD data from the National Ocean Service, Rockville, MD circulation survey of Willapa Bay and Grays Harbor, Washington. These data were collected...

  20. 75 FR 32783 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2010-06-09

    ... Healthcare Research and Quality (AHRQ) to request that the Office of Management and Budget (OMB) approve the... Positive Deviance and Lean in Reducing MRSA. Presentation at AHRQ Annual Meeting, Rockville, MD. Sept 2009...

  1. 10 CFR Appendix A to Part 52 - Design Certification Rule for the U.S. Advanced Boiling Water Reactor

    Science.gov (United States)

    2010-01-01

    ...), Rockville, Maryland 20852. Copies are also available for examination at the NRC Library located at Two White...) Instrument setpoint methodology. (11) EMS performance specifications and architecture. (12) SSLC hardware and...

  2. 77 FR 69506 - Exelon Generation Company, LLC., Oyster Creek Nuclear Generating Station; Exemption

    Science.gov (United States)

    2012-11-19

    ... unit'' to ``The closed head automatic sprinkler system in the condenser bay area was designed... the time of design.'' Dated in Rockville, Maryland, this 9th day of November 2012. For the Nuclear...

  3. 77 FR 64834 - Exelon Generation Company, LLC; Oyster Creek Nuclear Generating Station; Exemption

    Science.gov (United States)

    2012-10-23

    ... oil unit,'' to ``The closed head automatic sprinkler system in the condenser bay area was designed... the time of design.'' Dated in Rockville, Maryland, this 15th day of October 2012. For the Nuclear...

  4. 76 FR 58277 - Animal Generic Drug User Fee Act; Public Meeting; Request for Comments

    Science.gov (United States)

    2011-09-20

    ... support for lower-cost alternatives to brand drugs for consumers. Under AGDUFA, FDA agreed to meet review... Parklawn Dr., Element Bldg., Rockville, MD 20857. Dated: September 13, 2011. Leslie Kux, Acting Assistant...

  5. 77 FR 72359 - Animal Generic Drug User Fee Act; Public Meeting; Request for Comments

    Science.gov (United States)

    2012-12-05

    ... Parklawn Dr., Element Bldg., Rockville, MD 20857. Comments: Interested persons may submit either written... to brand name drugs for consumers. Under AGDUFA I, FDA agreed to meet review performance goals for...

  6. 76 FR 24062 - Florida Power and Light Company, St. Lucie, Unit Nos. 1 and 2; Exemption

    Science.gov (United States)

    2011-04-29

    ... shifts of workers consisting of personnel from operations, maintenance, health physics, chemistry... Rockville, Maryland, this 22nd day of April 2011. For the Nuclear Regulatory Commission. Robert A. Nelson...

  7. 78 FR 70954 - Transport Format for the Submission of Regulatory Study Data; Notice of Pilot Project

    Science.gov (United States)

    2013-11-27

    ... of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1062, Rockville..., 301-796- 5333, ronald[email protected] ; or Stephen Ripley, Center for Biologics Evaluation and...

  8. Tanzania Dental Journal Vol. 15 No. 1, May 2008 25

    African Journals Online (AJOL)

    Windows User

    of organizations allowing them to pool resources, avoid duplication and minimize impact. It encourages ... The results of the International. Collaborative .... health professionals in the Clinical, Dental,. Diagnostics ..... Research. Rockville, MD ...

  9. 75 FR 15437 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Science.gov (United States)

    2010-03-29

    ...) hours 500 1 1.5 750 Send comments to Summer King, SAMHSA Reports Clearance Officer, Room 7-1044, One Choke Cherry Road, Rockville, MD 20857. Written comments should be received within 60 days of this...

  10. 76 FR 40924 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-07-12

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  11. 76 FR 75889 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-12-05

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, (651) 636-7466/(800...

  12. 76 FR 18770 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-04-05

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy...

  13. 76 FR 54477 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-09-01

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857..., St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy Laboratory Services, 1225 NE 2nd Ave...

  14. 77 FR 12862 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-03-02

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy...

  15. 76 FR 31969 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-06-02

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  16. 78 FR 14100 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2013-03-04

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratory Services, a Division of LabOne, Inc.,) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul...

  17. 75 FR 45128 - Current List of Laboratories Which Meet Minimum Standards To Engage in Urine Drug Testing for...

    Science.gov (United States)

    2010-08-02

    .../CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857; 240-276-2600 (voice), 240-276-2610... Analytics Inc., NOVAMANN (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

  18. 77 FR 69642 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-11-20

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

  19. 77 FR 71605 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-12-03

    ... Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville... Analytics Inc., NOVAMANN (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

  20. 77 FR 45645 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-08-01

    ... Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy...

  1. 77 FR 126 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-01-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, (651) 636-7466/(800) 832-3244...

  2. 76 FR 24501 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-05-02

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

  3. 78 FR 314 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2013-01-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244 MetroLab-Legacy Laboratory Services...

  4. 76 FR 161 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-01-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... certification maintenance program. MedTox Laboratories, Inc., 402 W. County Road D,St. Paul, MN 55112. 651-636...

  5. 77 FR 26022 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-05-02

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  6. 76 FR 61110 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-10-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857.... Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy Laboratory Services, 1225 NE 2nd Ave...

  7. 78 FR 25461 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2013-05-01

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857.... County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy Laboratory Services, 1225...

  8. 76 FR 6147 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-02-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112. 651-636-7466/800-832-3244. Metro...

  9. 76 FR 11802 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-03-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244; MetroLab-Legacy...

  10. 77 FR 5037 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-02-01

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.); MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  11. 78 FR 33429 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2013-06-04

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857....). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. Metro...

  12. 78 FR 19500 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2013-04-01

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244 MetroLab-Legacy Laboratory Services...

  13. 75 FR 67749 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2010-11-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy...

  14. 76 FR 68201 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-11-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857..., Inc., 402 W. County Road D, St. Paul, MN 55112, (651) 636-7466/(800) 832-3244. MetroLab-Legacy...

  15. 76 FR 46309 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2011-08-02

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... (Ontario), Inc.) MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832...

  16. 77 FR 32653 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-06-01

    ... Hersh, Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville... Analytics Inc., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN...

  17. 77 FR 60449 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-10-03

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857... Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636-7466/800-832-3244. MetroLab-Legacy...

  18. 77 FR 20832 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-04-06

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  19. 77 FR 54597 - Current List of Laboratories and Instrumented Initial Testing Facilities Which Meet Minimum...

    Science.gov (United States)

    2012-09-05

    ..., Division of Workplace Programs, SAMHSA/CSAP, Room 2-1042, One Choke Cherry Road, Rockville, Maryland 20857...., NOVAMANN (Ontario), Inc.). MedTox Laboratories, Inc., 402 W. County Road D, St. Paul, MN 55112, 651-636...

  20. 78 FR 13071 - Guidance for Industry: Implementation of an Acceptable Full-Length and Abbreviated Donor History...

    Science.gov (United States)

    2013-02-26

    ... 20852- 1448. Send one self-addressed adhesive label to assist the office in processing your requests... of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, rm. 1061, Rockville...

  1. 78 FR 7786 - International Conference on Harmonisation; Draft Guidance on S10 Photosafety Evaluation of...

    Science.gov (United States)

    2013-02-04

    ... assist the office in processing your requests. See the SUPPLEMENTARY INFORMATION section for electronic... Administration, 5630 Fishers Lane, rm. 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Regarding the...

  2. 78 FR 37230 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    Science.gov (United States)

    2013-06-20

    ... 20993-0002. Send one self-addressed adhesive label to assist that office in processing your requests..., 5630 Fishers Lane, Rm. 1061, Rockville, MD 20852. FOR FURTHER INFORMATION CONTACT: Kris Andr[eacute...

  3. 21 CFR 60.10 - FDA assistance on eligibility.

    Science.gov (United States)

    2010-04-01

    ... from the U.S. Patent and Trademark Office, FDA will assist the U.S. Patent and Trademark Office in... in FDA's Division of Dockets Management (HFA-305), 5630 Fishers Lane, rm. 1061, Rockville, MD 20852...

  4. 21 CFR 20.40 - Filing a request for records.

    Science.gov (United States)

    2010-04-01

    ... Information Staff (HFI-35), Food and Drug Administration, rm. 12A-16, 5600 Fishers Lane, Rockville, MD 20857... shall be made by the Food and Drug Administration to assist in the identification and location of the...

  5. 75 FR 22812 - Guidance for Industry on Tobacco Health Document Submission; Availability; Correction

    Science.gov (United States)

    2010-04-30

    ... Lane, Rockville, MD 20957, 301-827-7010. SUPPLEMENTARY INFORMATION: In FR Doc. 2010-9134, appearing on...: ``Send one self-addressed adhesive label to assist that office in processing your request or include a...

  6. 78 FR 11656 - Agency Information Collection Activities: Proposed Collection: Comment Request

    Science.gov (United States)

    2013-02-19

    ... initiatives and assist sites in improving their retention outcomes. The survey will ask site administrators to... the HRSA Reports Clearance Officer, Room 10-33, Parklawn Building, 5600 Fishers Lane, Rockville, MD...

  7. Genetic Underpinnings of Alopecia Areata

    Medline Plus

    Full Text Available ... 14, 2017 See All Press Releases Upcoming and Recent Events Advisory Council Meetings The meetings, held three ... Open Source Data Public Data Listing NIH...Turning Discovery Into Health® National Institutes of Health, 9000 Rockville ...

  8. 76 FR 76744 - Prospective Grant of Exclusive License: Use of Agents Targeting Thrombospondin-1 and CD47 To...

    Science.gov (United States)

    2011-12-08

    ...,'' to Radiation Control Technologies, Inc., a company incorporated under the laws of the State of Delaware having its headquarters in Rockville, Maryland. The United States of America is the assignee of...

  9. 77 FR 63843 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2012-10-17

    ...: To review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center... of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference... Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs, National...

  10. 77 FR 75179 - National Institute on Drug Abuse Notice of Closed Meetings

    Science.gov (United States)

    2012-12-19

    ... Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Telephone Conference Call... review and evaluate grant applications. Place: National Institutes of Health, Neuroscience Center, 6001... Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs, National...

  11. 78 FR 4421 - National Institute on Drug Abuse; Notice of Closed Meetings

    Science.gov (United States)

    2013-01-22

    ...: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852... contract proposals. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard... Federal Domestic Assistance Program Nos.: 93.279, Drug Abuse and Addiction Research Programs, National...

  12. 77 FR 3480 - National Institute on Drug Abuse, Notice of Closed Meetings

    Science.gov (United States)

    2012-01-24

    ... grant applications. Place: National Institutes of Health, Neuroscience Center, 6001 Executive Boulevard... Institutes of Health, Neuroscience Center, 6001 Executive Boulevard, Rockville, MD 20852, (Virtual Meeting..., Drug Abuse and Addiction Research Programs, National Institutes of Health, HHS) Dated: January 18, 2012...

  13. 77 FR 55509 - Indiana Michigan Power Company; Donald C. Cook Nuclear Plant, Unit 2; Exemption

    Science.gov (United States)

    2012-09-10

    ... significant effect on the quality of the human environment and has published an environmental assessment for... Rockville, Maryland, this 23rd day of August, 2012. For the Nuclear Regulatory Commission. Michele Evans...

  14. Ideas and Inspirations: Good News about Diabetes Prevention and Management in Indian Country

    Medline Plus

    Full Text Available ... Treatment for the Prevention of Diabetes Richard Arakaki, MD Area Diabetes Consultant Phoenix Area IHS Stay Connected ... Headquarters, Indian Health Service, 5600 Fishers Lane, Rockville, MD 20857 - Find a Mail Stop Office Mail Stops ...

  15. 78 FR 64029 - Cost-Benefit Analysis for Radwaste Systems for Light-Water-Cooled Nuclear Power Reactors

    Science.gov (United States)

    2013-10-25

    ... INFORMATION CONTACT: Stephen C. Burton, Region III, telephone: 301-415-7000; email: Stephen[email protected] , U... at Rockville, Maryland, this 7th day of October 2013. For the Nuclear Regulatory Commission. Thomas H...

  16. 76 FR 77855 - Detroit Edison Company; Notice of Availability of Errata Sheet for the Draft Environmental Impact...

    Science.gov (United States)

    2011-12-14

    ... Information Contact: Mr. Bruce Olson, Project manager, Environmental Projects Branch 2, Division of New.... Telephone: (301) 415-3731; email: Bruce.Olson@nrc.gov . Dated at Rockville, Maryland, this 7th day of...

  17. Life Outside NCI | Cancer Prevention Fellowship Program

    Science.gov (United States)

    The CPFP Office is located at the NCI facilities in Rockville, Maryland, near the Nation’s Capital. With the convenient Metro subway reaching throughout the metropolitan area, transportation is within easy reach.

  18. Evolution of System Safety at NASA as Related to Defense-in-Depth

    Science.gov (United States)

    Dezfuli, Homayoon

    2015-01-01

    Presentation given at the Defense-in-Depth Inter-Agency Workshop on August 26, 2015 in Rockville, MD by Homayoon Dezfuli. The presentation addresses the evolution of system safety at NASA as related to Defense-in-Depth.

  19. 75 FR 14207 - Virginia Electric and Power Company d/b/a/Dominion Virginia Power, and Old Dominion Electric...

    Science.gov (United States)

    2010-03-24

    ..., VA. For Further Information, Contact: Alicia Williamson, Project Manager, Environmental Projects...-mail to Alicia[email protected] . Dated at Rockville, Maryland, this 17th day of March 2010. For the...

  20. Inter- and size-specific patterns of fish seasonal migration between a shallow lake and its streams

    DEFF Research Database (Denmark)

    Skov, Christian; Brodersen, J.; Nilsson, P.A.

    2008-01-01

    This study used passive telemetry (passive integrated transponders) to evaluate winter migration in three species of cyprinids (roach (Rutilus rutilus (L.)), white bream (Blicca bjoerkna (L.)) and rudd (Scardinius erythrophthalmus (L.))) and their potential predators (pike (Esox lucius (L.)) and ...

  1. Feeding under predation risk: potential sex-specific response of perch (Perca fluviatilis).

    Czech Academy of Sciences Publication Activity Database

    Estlander, Satu; Nurminen, L.

    2014-01-01

    Roč. 23, č. 3 (2014), s. 478-480 ISSN 0906-6691 Institutional support: RVO:60077344 Keywords : foraging * sexual size dimorphism * predation * perch * pike Subject RIV: EH - Ecology, Behaviour Impact factor: 1.701, year: 2014

  2. Tallinna lennujaam - rehielamusse kätketud vene ja prantsuse modernsus / Signe Kalberg

    Index Scriptorium Estoniae

    Kalberg, Signe, 1959-

    2009-01-01

    Konkursil "Aasta Betoonehitis 2008" Eesti aasta betoonehitise tiitli pälvinud Tallinna lennujaama reisiterminali laiendusest. Arhitekt: Jean-Marie Bonnard, Sofreavia SA, Prantsusmaa. Projekteerija: AS EA Reng. Konstruktsioonid: OÜ Inseneribüroo Pike. Ehitaja: AS Skanska EMV

  3. 14. III 5. betoonipäeval teatati betoonikonkursi võitjad

    Index Scriptorium Estoniae

    2005-01-01

    Konkursi peapreemia pälvis Martin Aunin (Ülemiste hotell), projekteerija auhinna AS EA Reng, konstruktsioonide auhinna inseneribüroo Pike OÜ, ehitaja auhinna AS FKSM ja betooni auhinna AS HC Betoon

  4. Pärnu Kontserdimaja : Pärnu, Aida tn. 4 / Katrin Koov

    Index Scriptorium Estoniae

    Koov, Katrin, 1973-

    2003-01-01

    Projekteerija: COO Arhitektid. Arhitektid-sisekujundajad Hanno Grossschmidt, Kaire Nõmm, Katrin Koov. Konstruktor: Inseneribüroo Pike OÜ. Projekt: jaanuar 2002, valmis: november 2002. I ja II korruse plaan, 2 välis- ja 3 sisevaadet

  5. 77 FR 58900 - Mississippi Disaster #MS-00060

    Science.gov (United States)

    2012-09-24

    ... 09/11/2012. Incident: Hurricane Isaac. Incident Period: 08/26/2012 through 09/11/2012. DATES..., Newton, Pearl River, Perry, Pike, Smith, Stone, Walthall, Wayne, Wilkinson. The Interest Rates are...

  6. Cloning, sequencing and expression of cDNA encoding growth ...

    Indian Academy of Sciences (India)

    Unknown

    of medicine, animal husbandry, fish farming and animal ..... northern pike (Esox lucius) growth hormone; Mol. Mar. Biol. ... prolactin 1-luciferase fusion gene in African catfish and ... 1988 Cloning and sequencing of cDNA that encodes goat.

  7. City Plaza - intervjuu konstruktor Tiit Massoga / Tiit Masso ; interv. Martin Jänes

    Index Scriptorium Estoniae

    Masso, Tiit, 1935-

    2005-01-01

    Konkursil "Aasta betoonehitis 2004" pälvis City Plaza eriauhinna insenertehnilise lahenduse eest. Arhitektuur: OÜ Alver Trummal Arhitektid, projekteerija: IB Pike OÜ, Tiit Masso, ehitaja: Estconde-E OÜ. Ill.:4 välisvaadet, sisevaade

  8. Alabama Cooperative Extension System - ACES.edu

    Science.gov (United States)

    Marshall Mobile Monroe Montgomery Morgan Perry Pickens Pike Randolph Russell Shelby St. Clair Sumter Marengo Tuscaloosa Greene Pickens Sumter Conecuh Escambia Monroe Clarke Choctaw Washington Baldwin Mobile Office Communications & Marketing Information Technology ACES Publications & Store 4-H &

  9. EPRA avas 20. tegevushooaja

    Index Scriptorium Estoniae

    2015-01-01

    15. septembril oli EPRA-l külas kogenud briti suhtekorraldaja ja ajalehe The Sun endine toimetaja Stuart Higgins ning Eestis veel katmata ala, õigusala meediaekspert Julian Pike. Selle kohtumisega avas EPRA oma 20. tegevushooaja

  10. 76 FR 32387 - Kentucky Disaster Number KY-00040

    Science.gov (United States)

    2011-06-06

    ... Damage and Economic Injury Loans): Ballard, Daviess, Henderson, Lawrence, McLean, Pike. Contiguous..., Morgan, Muhlenberg, Ohio. Illinois: Alexander. Indiana: Spencer, Vanderburgh, Warrick. Virginia: Buchanan, Dickenson, Wise. West Virginia: Mingo. All other information in the original declaration remains unchanged...

  11. 77 FR 32651 - National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meetings

    Science.gov (United States)

    2012-06-01

    ... meetings. The meetings will be closed to the public in accordance with the provisions set forth in sections...). Contact Person: Charles H Washabaugh, Ph.D., Scientific Review Officer, Scientific Review Branch, National... applications. Place: Bethesda Marriott, 5151 Pooks Hill Road, Bethesda, MD 20814. Contact Person: Charles N...

  12. 78 FR 57168 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-09-17

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... grant applications. Place: Washington Hilton Hotel, 1919 Connecticut Ave. NW., Washington, DC 20009... Hotel Bethesda, (Formerly Holiday Inn Select), 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person...

  13. 77 FR 76298 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2012-12-27

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... grant applications. Place: DoubleTree by Hilton Hotel Bethesda--Washington DC, 8120 Wisconsin Avenue... evaluate grant applications and/or proposals. Place: DoubleTree by Hilton Hotel Bethesda--Washington DC...

  14. 75 FR 48978 - National Institute of Allergy and Infectious Diseases; Notice of Meetings

    Science.gov (United States)

    2010-08-12

    ... Committee Act, as amended (5 U.S.C. App.), notice is hereby given of meetings of the National Advisory... institute Director. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Salon D.../or proposals. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Salon D...

  15. 77 FR 2737 - National Institute on Aging; Notice of Closed Meetings

    Science.gov (United States)

    2012-01-19

    ...; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee Act, as amended (5... Hotel Bethesda, 8120 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Bita Nakhai, Ph.D.... to 3 p.m. Agenda: To review and evaluate grant applications. Place: DoubleTree by Hilton Hotel...

  16. 76 FR 27070 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-05-10

    ...: Cardiovascular Devices. Date: June 20, 2011. Time: 8 a.m. to 5 p.m. Agenda: To review and evaluate grant... Abuse Research Using Existing Epidemiology, Prevention, and Treatment Research Data. Date: June 20-21... applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, North Bethesda, MD...

  17. 78 FR 9931 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-12

    ... Bethesda Metro Center, 7400 Wisconsin Avenue, Bethesda, MD 20814. Contact Person: Abdelouahab Aitouche, Ph...). Contact Person: James J Li, Ph.D., Scientific Review Officer, Center for Scientific Review, National...: Chemistry, Biochemistry and Biophysics Date: March 6-7, 2013 Time: 8:30 a.m. to 5:00 p.m. Agenda: To review...

  18. 78 FR 1265 - Sunshine Act; Notice of Meeting

    Science.gov (United States)

    2013-01-08

    ... South (both entry and exit). For those attending the La Jolla meeting, parking is expected to be..., 4340 East-West Highway, Room 700, Bethesda, Maryland 20814. The Commission already has met with...: Timothy J. Ragen, Executive Director, Marine Mammal Commission, 4340 East-West Highway, Room 700, Bethesda...

  19. 77 FR 66623 - National Institute on Minority Health and Health Disparities; Notice of Closed Meeting

    Science.gov (United States)

    2012-11-06

    ... and Health Disparities Special Emphasis Panel; NIMHD Community-Based Participatory Research (CBPR... Marriott Suites, 6711 Democracy Boulevard, Bethesda, MD 20817. Contact Person: Robert Nettey, M.D., Chief... of Health, 6707 Democracy Blvd., Suite 800, Bethesda, MD 20892, (301) 496-3996, [email protected

  20. 78 FR 8156 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Cancer Institute... proposals. Place: Bethesda North Marriott Hotel & Conference Center, Montgomery County Conference Center... Institute, NIH, 6116 Executive Blvd., Suite 703, Room 7072, Bethesda, md 20892-8329, 301-594-1408, Stoicaa2...

  1. 78 FR 70567 - Center for Scientific Review; Amended Notice of Meeting

    Science.gov (United States)

    2013-11-26

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Center for Scientific Review... Institutes of Health, 6701 Rockledge Drive, Room 3091, Bethesda, MD, 20892 which was published in the Federal Register on September 18, 2013, 78 FR 57399. The meeting will be held at the Bethesda Marriott Hotel, 5151...

  2. 78 FR 66034 - National Cancer Institute; Notice of Meeting

    Science.gov (United States)

    2013-11-04

    ... consideration of personnel qualifications and performance and the competence of individual investigators... Cancer Advisory Board; Ad hoc Subcommittee on Communications. Open: December 9, 2013, 7:45 p.m. to 9:15 p.m. Agenda: Discussion on Communications. Place: Hyatt Regency Bethesda, One Bethesda Metro Center...

  3. Structural and Functional Studies on the Fusion and Attachment Envelope Glycoproteins of Nipah Virus and Hendra Virus

    Science.gov (United States)

    2003-01-01

    including measles virus (MeV), mumps virus, Sendai virus (SeV), Newcastle disease virus (NDV), rinderpest virus, canine distemper virus (CDV), human...Institute of Health, Bethesda, MD. Hut 102, MT2, MT4, and CEM human T cell lines were provided by Chou-Zen Giam, USUHS, Bethesda, MD. The human osteosarcoma

  4. 77 FR 6809 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2012-02-09

    ... 7770, Bethesda, MD 20892, 301 806-0009, [email protected]csr.nih.gov . Name of Committee: Healthcare..., Room 3166, MSC 7770, Bethesda, MD 20892, 301-254-9975, [email protected]csr.nih.gov . Name of Committee... Committee: Healthcare Delivery and Methodologies Integrated Review Group Community-Level Health Promotion...

  5. 78 FR 27247 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-05-09

    ... 5176 MSC 7844, Bethesda, MD 20892, (301) 435-1713, [email protected]csr.nih.gov . Name of Committee: Healthcare Delivery and Methodologies Integrated Review Group; Community-Level Health Promotion Study Section. Date... Rockledge Drive, Room 3166, Bethesda, MD 20892, 301-451-8428, [email protected]csr.nih.gov . Name of Committee...

  6. 76 FR 17930 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-03-31

    ... Nanotechnology. Date: July 12-13, 2011. Time: 8 a.m. to 6 p.m. Agenda: To review and evaluate grant applications... review and evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Gerald G. Lovinger, PhD, Scientific Review Administrator...

  7. 76 FR 372 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-04

    ... 7770, Bethesda, MD 20892, (301) 435- 0684, [email protected] . Name of Committee: Oncology 1--Basic..., Bethesda, MD 20892, 301-495- 1718, [email protected] . Name of Committee: Biological Chemistry and Macromolecular Biophysics Integrated Review Group; Synthetic and Biological Chemistry B Study Section. Date...

  8. 75 FR 41212 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-07-15

    ..., Bethesda, MD 20892, 301-435- 1259, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... Health, 6701 Rockledge Drive, Room 5202, MSC 7850, Bethesda, MD 20892, (301) 435-0910, [email protected]csr.nih...

  9. 78 FR 69430 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-19

    ... Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892, 301-435- 0903, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by... Health, 6701 Rockledge Drive, Room 3211, MSC 7808, Bethesda, MD 20892,301-435- 0903, [email protected]csr.nih.gov...

  10. 78 FR 45252 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-07-26

    ... 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle... Health, 6701 Rockledge Drive, Room 3130, MSC 7850, Bethesda, MD 20892, 301-435-3009, [email protected]csr.nih.gov...

  11. 75 FR 13767 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2010-03-23

    ... Rockledge Drive, Room 5218, MSC 7852, Bethesda, MD 20892, 301-435- 1775, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by..., Bethesda, MD 20892, 301-435- 4514, [email protected]csr.nih.gov . This notice is being published less than 15 days...

  12. 78 FR 66754 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2013-11-06

    ..., Bethesda, MD 20892, 301-435- 0677, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... 7844, Bethesda, MD 20892, (301) 806-3323, [email protected]csr.nih.gov . Name of Committee: Center for...

  13. 76 FR 31966 - Center for Scientific Review; Notice of Closed Meetings

    Science.gov (United States)

    2011-06-02

    ..., Bethesda, MD 20892, 301-435- 1259, [email protected]csr.nih.gov . This notice is being published less than 15 days prior to the meeting due to the timing limitations imposed by the review and funding cycle. Name of... Health, 6701 Rockledge Drive, Room 4811, MSC 7850, Bethesda, MD 20892, 301-435-1203, [email protected]csr.nih.gov...

  14. 78 FR 8157 - National Cancer Institute; Notice of Closed Meetings

    Science.gov (United States)

    2013-02-05

    ... Stage Development of Emerging Technologies in Biospecimen Science. Date: February 20, 2013. Time: 12:00... Marriott Hotel & Conference Center, 5701 Marinelli Road, Bethesda, MD 20852. Contact Person: Ellen K... p.m. Agenda: To review and evaluate grant applications. Place: Bethesda North Marriott Hotel...

  15. Messages of invasive Perccottus glenii individuals eaten by an Esox lucius from the Danube Delta

    Directory of Open Access Journals (Sweden)

    Ilie Cătălin Telcean

    2016-12-01

    Full Text Available In the stomach of a pike from the Danube Delta we have found seven Perccottus glenii individuals. Their message indicated that in the Danube Delta P. glenii has already large population. Also, it proves that in its habitats, the pike can consume numerous individuals of this invasive species. Their gut contents prove that P. glenii hunted near the shores, ingesting numerous terrestrial preys.

  16. Parima betoonehitise konkurss aasta-aastalt populaarsem / Aadu Kana

    Index Scriptorium Estoniae

    Kana, Aadu

    2005-01-01

    Aasta betoonehitis 2004 - Ülemiste hotell, arhitekt Martin Aunin, projekteerija AS EA Reng, konstruktsioonid: IB Pike, ehitaja AS FKSM, betoon: AS HC Betoon. Eeriauhinnad: Rakvere spordihalli ja Veskimöldre lasteaia betoonelementide tootja E-Betoonelement, IB Pike ja Tiit Masso City Plaza konstruktsioonide eest, Kakumäel asuva eramu tellija ja sisekujundaja Raina Lillepõld huvitava lähenemise eest

  17. Proposal for a novel management of indeterminate thyroid nodules on the basis of cytopathological subclasses.

    Science.gov (United States)

    Rossi, Martina; Lupo, Sabrina; Rossi, Roberta; Franceschetti, Paola; Trasforini, Giorgio; Bruni, Stefania; Tagliati, Federico; Buratto, Mattia; Lanza, Giovanni; Damiani, Luca; Degli Uberti, Ettore; Zatelli, Maria Chiara

    2017-07-01

    Indeterminate thyroid nodules include heterogeneous lesions that could benefit from a differential management. Our aim is to better define the management of the Bethesda System for Reporting Thyroid Cytopathology class III and IV nodules, by identifying cytological subcategories among Bethesda System for Reporting Thyroid Cytopathology class III associated with different clinical risk, by means of ultrasound, repeated FNAB, and BRAFV600E molecular analysis. We also evaluated the outcome of nodules not operated, over a 5-year follow-up. Out of 460 nodules (269 Bethesda System for Reporting Thyroid Cytopathology class III and 191 Bethesda System for Reporting Thyroid Cytopathology class IV), 344 were operated on surgical group and 116 followed-up conservatively (follow-up group). Bethesda System for Reporting Thyroid Cytopathology class III was divided into four subcategories on the basis of cytomorphological features (III-1, III-2, III-3, III-4). Clinical risk was defined on the basis of histological, cytological, and ultrasound data. Malignancy was higher in Bethesda System for Reporting Thyroid Cytopathology class III vs. Bethesda System for Reporting Thyroid Cytopathology class IV (34.4 vs. 26.2 %; p management of Bethesda System for Reporting Thyroid Cytopathology III and IV classes and related subcategories: surgery may be indicated in Bethesda System for Reporting Thyroid Cytopathology class III-1, III-4, and IV; a conservative follow-up avoiding repeated FNAB may be appropriated in class III-3, while repeated FNAB may be useful in class III-2.

  18. 76 FR 71580 - National Heart, Lung, and Blood Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-11-18

    ... Act, as amended (5 U.S.C. App.), notice is hereby given of the following meeting. The meeting will be... Drive, Bethesda, MD 20892, (Telephone Conference Call). Contact Person: Charles Joyce, Ph.D., Scientific...

  19. 75 FR 62547 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-10-12

    .... Place: Double Tree Hotel, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: November 16, 2010, 9 a.m. to... will be asked to show one form of identification (for example, a government-issued photo ID, driver's...

  20. 75 FR 6043 - National Cancer Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-05

    ... Tree Hotel, 8120 Wisconsin Avenue, Bethesda, MD 20814. Time: March 16, 2010, 9 p.m. to 2:30 p.m. Agenda... show one form of identification (for example, a government-issued photo ID, driver's license, or...

  1. 77 FR 10539 - National Institute of Dental & Craniofacial Research; Notice of Closed Meeting

    Science.gov (United States)

    2012-02-22

    ... Research Special Emphasis Panel; RFA DE12-004 & 005 Functional Restoration of Salivary Glands. Date: March... Garden Inn, 7301 Waverly St., Bethesda, MD 20814. Contact Person: Marilyn Moore-Hoon, Ph.D., Scientific...

  2. Logistics | Division of Cancer Prevention

    Science.gov (United States)

    Date and Time Registration will begin at 8:30 am on Friday, September 20th. The meeting will begin promptly at 9:00 am. Location NIH Campus Natcher Conference Center Building 45 45 Center Drive Bethesda, MD |

  3. Urge incontinence

    Science.gov (United States)

    ... and are not able to store much urine. Augmentation cystoplasty is the surgery most often performed for ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  4. Surgical wound care

    Science.gov (United States)

    ... replacement Anti-reflux surgery Bladder exstrophy repair Breast augmentation surgery Breast lump removal Bunion removal Carotid artery ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  5. Chin augmentation - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100009.htm Chin augmentation - series—Normal anatomy To use the sharing features ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  6. Breast augmentation - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100205.htm Breast augmentation - series—Normal anatomy To use the sharing features ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  7. Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer

    NARCIS (Netherlands)

    de Jong, Andrea E.; van Puijenbroek, Marjo; Hendriks, Yvonne; Tops, Carli; Wijnen, Juul; Ausems, Margreet G. E. M.; Meijers-Heijboer, Hanne; Wagner, Anja; van Os, Theo A. M.; Bröcker-Vriends, Annette H. J. T.; Vasen, Hans F. A.; Morreau, Hans

    2004-01-01

    Immunohistochemistry (IHC) and microsatellite instability (MSI) analysis can be used to identify patients with a possible DNA mismatch repair defect [hereditary nonpolyposis colorectal carcinoma (HNPCC)]. The Bethesda criteria have been proposed to select families for determination of MSI. The aims

  8. Development of the Young Brain

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... U.S. Department of Health and Human Services National Institutes of Health USA.gov The ...

  9. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, MD ... U.S. Department of Health and Human Services National Institutes of Health USA.gov The ...

  10. 76 FR 54238 - Center for Scientific Review; Notice of Closed Meeting

    Science.gov (United States)

    2011-08-31

    ...: Language, Communication, Cognition and Perception. Date: September 13-14, 2011. Time: 10 a.m. to 8 p.m... Drive, Bethesda, MD 20892 (Virtual Meeting). Contact Person: Jane A Doussard-Roosevelt, PhD, Scientific...

  11. Clinical Trials

    Medline Plus

    Full Text Available ... process often begins in a laboratory (lab), where scientists first develop and test new ideas. If an ... NIH campus in Bethesda, Maryland. The physicians, nurses, scientists and staff of the NHLBI encourage you to ...

  12. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 117; Issue 6 ... oxidation of methane in coastal sediment from Guishan Island (Pearl River Estuary), South China Sea ... National Institute of Health, Bethesda, Maryland 20892, USA.

  13. Development of the Young Brain

    Medline Plus

    Full Text Available ... When they get stuck in traffic. How they manage their time and their emotions. And this is ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  14. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... Trials Outreach Outreach Home Stakeholder Engagement Outreach Partnership Program Alliance for Research Progress Coalition for Research Progress ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  15. Development of the Young Brain

    Medline Plus

    Full Text Available ... Trials Outreach Outreach Home Stakeholder Engagement Outreach Partnership Program Alliance for Research Progress Coalition for Research Progress ... MSC 9663 Bethesda, MD 20892-9663 Follow Us Facebook Twitter YouTube Google Plus NIMH Newsletter NIMH RSS ...

  16. 76 FR 3640 - Notice of Closed Meetings

    Science.gov (United States)

    2011-01-20

    ... and evaluate grant applications. Place: Marina del Rey Hotel, 13534 Bali Way, Marina del Rey, CA 90292...: To review and evaluate grant applications. Place: Bethesda North Marriott Hotel & Conference Center...

  17. Symptoms and Treatment of Depression

    Medline Plus

    Full Text Available ... Application Process Managing Grants Clinical Research Training Small Business Research Labs at NIMH Labs at NIMH Home ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, ...

  18. Development of the Young Brain

    Medline Plus

    Full Text Available ... Application Process Managing Grants Clinical Research Training Small Business Research Labs at NIMH Labs at NIMH Home ... Mental Health Office of Science Policy, Planning, and Communications 6001 Executive Boulevard, Room 6200, MSC 9663 Bethesda, ...

  19. When the Stakes Turn Toxic: Learn about Problem Gambling

    Science.gov (United States)

    ... New York State Psychiatric Institute. “There is no stereotype. The main predictor of outcome is really motivation.” ... t stop. Links Compulsive Gambling NIH Office of Communications and Public Liaison Building 31, Room 5B52 Bethesda, ...

  20. How Loud Is Too Loud?

    Medline Plus

    Full Text Available ... Your Hearing (infographic) Noise-Induced Hearing Loss Tinnitus Communication Methods & Devices for People With Hearing Loss American ... Into Health ® National Institute on Deafness and Other Communication Disorders 31 Center Drive, MSC 2320, Bethesda, MD ...

  1. 76 FR 23828 - National Institute on Drug Abuse; Notice of Closed Meeting

    Science.gov (United States)

    2011-04-28

    ... unwarranted invasion of personal privacy. Name of Committee: National Institute on Drug Abuse Special Emphasis..., National Institute on Drug Abuse, NIH, DHHS, Room 4227, MSC 9550, 6001 Executive Boulevard, Bethesda, MD....279, Drug Abuse and [[Page 23829

  2. Eosinophilic Esophagitis

    Science.gov (United States)

    ... the esophagus, which can lead to difficulty swallowing (dysphagia) or food getting stuck in the esophagus. Reflux ... Irritable Bowel Syndrome Obesity ©2018 American College of Gastroenterology 6400 Goldsboro Rd Ste 200 Bethesda, MD 20817 ( ...

  3. Eosinophilic Esophagitis in Pediatric and Adolescent Patients

    Science.gov (United States)

    ... the feeling of food getting stuck (known as dysphagia), especially with solid meals. Dysphagia can lead to food impaction, where food suddenly ... Irritable Bowel Syndrome Obesity ©2018 American College of Gastroenterology 6400 Goldsboro Rd Ste 200 Bethesda, MD 20817 ( ...

  4. 78 FR 27977 - Office of Biotechnology Activities; Recombinant DNA Research: Proposed Actions Under the NIH...

    Science.gov (United States)

    2013-05-13

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Office of Biotechnology... Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines) SUMMARY: The NIH Office of Biotechnology... of Biotechnology Activities, National Institutes of Health, 6705 Rockledge Drive, Suite 750, Bethesda...

  5. Aging changes in the senses

    Science.gov (United States)

    ... A delicious meal or pleasant aroma can improve social interaction and enjoyment of life. Smell and taste also ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  6. Gender dysphoria

    Science.gov (United States)

    ... opposite sex Have depression or anxiety Withdraw from social interaction Exams and Tests The feeling of being in ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  7. Inhibitors

    Science.gov (United States)

    ... JM, and the Hemophilia Inhibitor Research Study Investigators. Validation of Nijmegen-Bethesda assay modifications to allow inhibitor ... webinars on blood disorders Language: English (US) Español (Spanish) File Formats Help: How do I view different ...

  8. The histological significance of atypical glandular cells on cervical ...

    African Journals Online (AJOL)

    The 2001 Bethesda System for Reporting Cervical Cytology[1] ... from the laboratory information software, Disa*Lab (Laboratory ... to identify predictors of pathology relevant to the clinical management of women with a cytological diagnosis of.

  9. Pulling a patient up in bed

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 12. Review Date 11/15/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  10. Small bowel resection - discharge

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 26. Read More Colon cancer Crohn ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  11. Getting yourself healthy before surgery

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Review Date 9/17/2016 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  12. Central venous catheter - flushing

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Read More Bone marrow transplant ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  13. Turning patients over in bed

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 12. Review Date 11/15/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  14. Nasogastric feeding tube

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 16. Ziegler TR. Malnutrition, nutritional assessment, ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  15. Peripherally inserted central catheter - dressing change

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Review Date 11/20/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  16. Peripherally inserted central catheter - flushing

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29.6. Read More Bone marrow ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  17. Central venous catheter - dressing change

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2017:chap 29. Read More Bone marrow transplant ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  18. Peripherally inserted central catheter - insertion

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 29. Review Date 11/20/2017 ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  19. Wet to dry dressing changes

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 25. Patient Instructions Cosmetic breast surgery - ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...

  20. Large bowel resection - discharge

    Science.gov (United States)

    ... to Advanced Skills . 9th ed. New York, NY: Pearson; 2016:chap 26. Read More Colon cancer Colostomy ... Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page last updated: ...