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Sample records for rnno lumiste alari

  1. Konverentsimuljeid tegijailt ja osalejailt / Monika Läänesaar, Ann Lumiste, Andrus Laansalu...[jt.] ; interv. Madis Kolk

    Index Scriptorium Estoniae

    2000-01-01

    Rahvusvahelisest konverentsist "Lavailm" ja näitusest "Teatrikunstnik...kes ta on?" (kuraator Ann Lumiste) Rotermanni soolalaos, teatrikunstniku positsioonist teatris, uue meedia ja teatri koostöö võimalikkusest, keskkonna ja visuaalsete elementide mõju lavastaja- ja näitlejatööle.

  2. An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.

    Science.gov (United States)

    Boukhatmi, Hadi; Schaub, Christoph; Bataillé, Laetitia; Reim, Ingolf; Frendo, Jean-Louis; Frasch, Manfred; Vincent, Alain

    2014-10-01

    The T-box transcription factor Tbx1 and the LIM-homeodomain transcription factor Islet1 are key components in regulatory circuits that generate myogenic and cardiogenic lineage diversity in chordates. We show here that Org-1 and Tup, the Drosophila orthologs of Tbx1 and Islet1, are co-expressed and required for formation of the heart-associated alary muscles (AMs) in the abdomen. The same holds true for lineage-related muscles in the thorax that have not been described previously, which we name thoracic alary-related muscles (TARMs). Lineage analyses identified the progenitor cell for each AM and TARM. Three-dimensional high-resolution analyses indicate that AMs and TARMs connect the exoskeleton to the aorta/heart and to different regions of the midgut, respectively, and surround-specific tracheal branches, pointing to an architectural role in the internal anatomy of the larva. Org-1 controls tup expression in the AM/TARM lineage by direct binding to two regulatory sites within an AM/TARM-specific cis-regulatory module, tupAME. The contributions of Org-1 and Tup to the specification of Drosophila AMs and TARMs provide new insights into the transcriptional control of Drosophila larval muscle diversification and highlight new parallels with gene regulatory networks involved in the specification of cardiopharyngeal mesodermal derivatives in chordates. © 2014. Published by The Company of Biologists Ltd.

  3. Uued teenused ja innovatsioonipoliitika teenindussektori arenguks / Rein Lumiste, Rünno Lumiste

    Index Scriptorium Estoniae

    Lumiste, Rein

    2003-01-01

    Teenindussektor on muutunud Eesti majanduse arengus määravaks: majanduse edasine areng ei saa toimuda ilma uute teenuste turule tulekuta, teenuse innovatsiooni ja selle innovatsiooni üht olulisemat osa, uute teenuste juurutamist peab soodustama riiklik innovatsiooni poliitika. Tabelid

  4. Nobeli preemia majanduse valitsemisstruktuuride uurijatele / Alari Purju

    Index Scriptorium Estoniae

    Purju, Alari, 1953-

    2009-01-01

    Rootsi Kuninglik Teaduste Akadeemia otsustas 2009. aasta Rootsi Keskpanga Nobeli mälestusauhinna majandusteaduse alal anda USA majandusteadlastele Elinor Ostromile Indiana ülikoolist ja Oliver E. Williamsonile Berkley California ülikoolist

  5. Tom Russell: "Õpetajakoolitust tuleks alustada praktikast" / Liisa Lumiste

    Index Scriptorium Estoniae

    Lumiste, Liisa

    2013-01-01

    Eduko programmi raames Tallinna Ülikoolis toimunud avalikul loengul rääkis Kanada kasvatusteadlane Tom Russell praktika tähtsusest õpetajakoolituses ja viis läbi meistriklassi õpetajakoolituse õppejõududele

  6. Globaliseerumine, delokaliseerumine ja katsed protsessi valitseda / Alari Purju

    Index Scriptorium Estoniae

    Purju, Alari

    2008-01-01

    Estonian Business Schoolþi professori hinnangul toob globaliseerumine endaga kaasa mitmetasandilise valitsemise, kus põimuvad rahvusvahelised organisatsioonid, piirkondlikud ühendused, rahvusriigid ja omavalitsused

  7. Vene ja prantsuse kunsti imetlemisest Londonis / Ann Alari

    Index Scriptorium Estoniae

    Alari, Ann

    2008-01-01

    Näitus "Venemaalt pärit prantsuse ja vene shedöövrid" kuningliku kunstiakadeemia saalides Londonis. Vaatluse all oli ajavahemik 1870 kuni 1925. Tööd olid pärit Moskvas elanud tekstiilitöösturitest suurärimeeste Sergei Shtshukini ja Ivan Morozovi kogudest, mis 1917. a. natsionaliseeriti. Kuraator Ann Dumas

  8. Competitiveness of Estonian Economy : some Dilemmas Looming Ahead / Alari Purju

    Index Scriptorium Estoniae

    Purju, Alari

    1999-01-01

    Eesti majandus on jõudnud avatud majanduse perioodist järgmisesse arenguetappi. Seoses sellega tõstatuvad probleemid praeguse makroökonoomilise strateegia seostamisest strukturaalsete reformidega. Eesti ühinemine Euroopa Liiduga

  9. Kolmest Eestis loodud tehiskeelest ja nende loojatest / Ülo Lumiste, Leo Võhandu

    Index Scriptorium Estoniae

    Lumiste, Ülo, 1929-2017

    2007-01-01

    Baltisakslane Edgar de Wahl (1867-1948) oli tehiskeele oksidentaal looja ja matemaatikaõpetaja Tallinna Reaalgümnaasiumis. Jakob Linzbach (1874-1953) ja Jaan Sarv (1877-1954) kujundasid oma kunstlikke märgikeeli, mida liigitatakse pasigraafia alla. Lisa: Esimene rahvusvaheline teoreetilise, matemaatilise ja rakendusliku keeleteaduse alane olümpiaad (8.-12. september 2003, Bulgaaria) : individuaalvõistluse ülesanne

  10. Raamat ainsana maailmas Tallinnas säilinud 16. sajandi käsikirjast / Vello Lumiste

    Index Scriptorium Estoniae

    Lumiste, Vello

    2008-01-01

    Rets. rmt.: Die Arithmetik-Vorlesung des Georg Joachim Rheticus Wittenberg 1536 : eine kommentierte Edition der Handschrift X-278 (8) der Estnischen Akademischen Bibliothek / herausgegeben von Stefan Deschauer. Augsburg, 2003. Lisa: Valitud osi käsikirjast

  11. Vennad Väisäläd / Ülo Lumiste

    Index Scriptorium Estoniae

    Lumiste, Ülo, 1929-2017

    2005-01-01

    Ülevaade kolme soome tippteadlase-akadeemiku Vilho (1889-1969), Yrjö (1891-1971) ja Kalle Väisälä (1893-1968) elukäigust, loomingust ja selle tähendusest tänapäeva teadusele. Rets. rmt.: Lehto, Olli. Oman tien kulkijat: veljekset Vilho, Yrjö ja Kalle Väisälä. Helsinki, 2004

  12. Privatiseerimine ja erastamisväärtpaberite kontseptsioon Eestis / Alari Purju

    Index Scriptorium Estoniae

    Purju, Alari, 1953-

    1994-01-01

    Ülevaade erastamisväärtpaberite (EVP) kasutamisest, EVPde väljaandmise ja kasutamise alustest, EVPde ja erastatava vara bilansiga seotud probleemidest. EVPde kasutamise mõjust majanduse struktuurile, korterite, maa ja ettevõtete erastamise iseärasustest. Uurimus. Ilmunud ka inglise keeles: Working Papers nr. 82, Stockholm Institute of East European Economics, March 1994

  13. Mitu elu on ühel majal? = How many lives does a building have? / Alari Allik

    Index Scriptorium Estoniae

    Allik, Alari

    2012-01-01

    Puidu korduskasutusest Jaapanis. Jaapani pühamute arhitektuurist, mis nõuab pidevat ümbertegemist. Säilinud arusaamast, et ehitusprojektide puhul on oluline mõelda läbi kõik etapid, kuna ühel hoonel võib olla mitu elu. Moodsatest majadest. Uuele elule ärganud tööstushoonetest Tallinnas. Tallinna Linnahallist, mis on läbi raskuste leidmas endale uusi funktsioone

  14. Peredele suunatud rahaliste toetuste mõju vaesuse leevendamisele Eestis / Andres Võrk, Alari Paulus

    Index Scriptorium Estoniae

    Võrk, Andres, 1974-

    2007-01-01

    PRAXIS-e uuringule toetuv artikkel jõuab järeldusele, et riiklikud peretoetused, vanemahüvitis ning täiendav maksuvaba tulu on vähendanud vaesuses elavate laste osakaalu, eriti positiivne on meetmete mõju olnud paljulastelistele peredele. Graafikud: Peredele suunatud rahaliste toetuste suurus; Peredele suunatud rahalised toetused ühe lapsetoetust saava lapse kohta keskmise palga ja tarbijahindadega võrreldes; Peredele suunatud rahaliste toetuste mõju absoluutses vaesuses elavate laste osakaalule; Peredele suunatud rahaliste toetuste mõju suhtelises vaesuses elavate laste ja lastega perede osakaalule aastail 2000-2005 keskmiselt; Suhtelises vaesuses elavate laste arvu vähenemine peredele suunatud rahaliste toetuste mõjul aastail 2000-2007 eri peretüüpides; Vaestele peredele minev toetuste osakaal aastate 2000-2005 kogutoetustest keskmiselt; Ühe protsendipunkti vaesuse vähendamise netokulu (arvestades koosmõju teiste toetuste ja maksudega) eri meetmetel 2004.-2005. aastal keskmiselt

  15. Eesti foto Londonis teeb meist "kuuma" riigi / Maris Lillak, Ann Alari

    Index Scriptorium Estoniae

    Lillak, Maris, 1970-

    2004-01-01

    Westminsteri parlamendihoones eesti fotonäitus "Similar Spaces" (Sarnased kohad - värsked fotod Eestist). Eksponeeritud Ly Lestbergi, Tarvo Hanno Varrese, Mare Tralla, Mark Raidpere, Raoul Kurvitza, Liina Siibi tööd. Kuraator Liina Siib

  16. Valged ööd ja Tallinn Londonis ehk 60 kraadi põhjalaiust / Ann Alari

    Index Scriptorium Estoniae

    Alari, Ann

    2009-01-01

    19. juunist 9. juulini toimub City of London Festival, millel osalevad Põhjamaad. Üheks oodatumaks sündmuseks on 30. juunil St Pauli katedraalis Inglise Rahvusballeti orkestri kontsert ja etendus "Chopiniana", kus tantsivad Age Oks ja Toomas Edur

  17. Res Publica tahab muuta Riigikogu kuluhüvitiste süsteemi / Alari Rammo

    Index Scriptorium Estoniae

    Rammo, Alari

    2003-01-01

    Riigikogu Res Publica fraktsiooni ettepanekutest reformida Riigikogu liikmetele ette nähtud kuluhüvitiste süsteemi. Tabel: Kasutatud kuluhüvitised seisuga 15. oktoober 2003. Kommenteerib Urmo Kübar

  18. Income inequality and its decomposition : the case of Estonia / Alari Paulus

    Index Scriptorium Estoniae

    Paulus, Alari

    2004-01-01

    Majandusliku ebavõrdsuse teoreetilistest aspektidest, mõjutavatest faktoritest, sissetulekute ebavõrdsuse mõõtmisest, dünaamikast Eestis 1996-2002, võrdlus teiste Euroopa riikidega. Skeem. Tabelid. Graafikud. Lisad lk. 231-235

  19. Eesti väike- ja keskmiste tööstusfirmade innovaatilise tegevuse finantseerimine / Rein Lumiste

    Index Scriptorium Estoniae

    Lumiste, Rein

    1999-01-01

    Bibliogr. lk. 16-17. - Kokkuvõte ingl. k. lk. 95. Peamine põhjus, miks pangad ei finantseeri väikeseid ja keskmisi ettevõtteid, on korrektse, regulaarse ja adekvaatse teabe puudumine firmade tegevuse ja nende omanike kohta. Tabel

  20. Tõlkemeistrite 141 selli / Triinu Tamm ; intervjueerinud Pille-Riin Larm ; kommenteerinud Heli Allik, Doris Kareva, Aare Pilv, Alari Allik

    Index Scriptorium Estoniae

    Tamm, Triinu

    2017-01-01

    Eesti Kirjanike Liidu tõlkijate sektsiooni noortele, gümnasistidele ja tudengitele suunatud ilukirjanduse tõlkevõistlusest ja koolitusest. Koos Tallinna ülikooli ja Postimehega käima lükatud uuel tõlkevõistlusel tõlgiti proosatekste vene, prantsuse, inglise ja jaapani keelest. Kommenteerivad tõlkevõistluse žüriide esindajad. Kõige rohkem töid oli Tartu ülikooli üliõpilastelt - 50, Tallinna ülikooli tudengeilt 25, gümnasistide töid oli 59

  1. Corporate Governance in Post-Socialist Countries - Theoretical Dilemmas, Peculiarities, Research Opportunities / Külliki Tafel, Erik Terk, Alari Purju

    Index Scriptorium Estoniae

    Tafel, Külliki

    2006-01-01

    Äriühingute valitsemine postsotsialistlikes riikides - teoreetilised dilemmad, eripärad, uurimisvõimalused. Skeemid: Internal and external relations of corporate governanace; The changing context of corporate governance

  2. Public governance institutions and their impact on delocalisation of labour intensive industries with evidences from Estonia / Kaarel Kilvits, Alari Purju

    Index Scriptorium Estoniae

    Kilvits, Kaarel

    2007-01-01

    Hargmaiste ettevõtete tootmise üleviimine ühest riigist teise on muutumas tähtsaks teemaks erinevates majandusharudes. Ala, kus kohtuvad ettevõtete majanduslikud huvid riigi poliitiliste eesmärkidega, on tööturu regulatsioon, otseste välisinvesteeringutega seotud probleemid, väliskaubanduse olukord, innovatsioon, maksundus ja riigi toetus. Tööstuspoliitikat, tööturu suhteid, välisinvesteeringuid mõjutavate protsesside kontseptsioonid Eesti elektroonika ning rõiva- ja tekstiilitööstuse näitel

  3. Euroopa majandushuvigrupp : [bakalaureusetöö] / Alari Avamägi ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Avamägi, Alari, 1974-

    1996-01-01

    Huvigrupi tegevusalused, mõiste ja tegevuse eesmärk, asutamine, organid, juhtimine ja otsuste vastuvõtmine, liikmete õigused ja kohustused, tegevustulemused, konkurentsi- ja maksuõiguslikud probleemid, huvigrupi lõpetamine. Vt. ka: Juridica (1996) nr. 6, lk. 280-282

  4. Asutamisvabadus kehtib ka madala maksumääraga territooriumidel : Euroopa Kohtu lahend : Cadbury Scweppes versus Suurbritannia / Alari Ossa

    Index Scriptorium Estoniae

    Ossa, Alari

    2006-01-01

    Euroopa Kohtu eelotsusetaotluse alusel tehtud lahendist (12. 09. 2006 C-196/04) Cadbury Schweppesþi ja Suurbritannia maksuhalduri vaidluse kohta, mis puudutas madala maksumääraga territooriumil asuva tütarühingu tulu omistamist Suurbritannia emaühingule

  5. Prohibition of torture, inhuman or degrading treatment and punishment : [Human Rights in Estonia 2016-2017] / Epp Lumiste, Kristena Paalmäe

    Index Scriptorium Estoniae

    Lumiste, Epp

    2018-01-01

    Euroopa Inimõiguste konventsiooni artikli 3 rakendamisest Eestis, inimväärika kohtlemise tagamisest kinnipidamisasutustes viibivatele isikutele, vastavast kohtupraktikast, õigusaktidest ja avalikest aruteludest

  6. Reaktsioon / Rait Avestik

    Index Scriptorium Estoniae

    Avestik, Rait, 1974-

    2007-01-01

    Vastukaja "Eesti Ekspressi" kultuurilisas "Areen" ilmunud Liina Jürgeni kirjutisele, kus autor veebipäeviku vormis kajastas Vanemuises etendunud ameerika kirjaniku Laura Cunninghami tragikomöödiat "Beautiful Bodies", lavastaja Jüri Lumiste

  7. Meie igapäevane paanika / Ott Karulin

    Index Scriptorium Estoniae

    Karulin, Ott, 1980-

    2007-01-01

    Kahest Vanemuise teatri lavastusest Tartus - Saksa Kultuuri Instituudis etendunud Ingvar Ambjornseni-Axel Hellsteniuse "Elling" Ain Mäeotsa lavastuses ja Laura Cunninghami "Beautiful Bodies" Vanemuises, lavastaja Jüri Lumiste

  8. Uued tuuled annetaja rahakotis / Mariliis Kannukene

    Index Scriptorium Estoniae

    Kannukene, Mariliis

    2006-01-01

    Mittetulundusühingute ja sihtasutuste tulumaksusoodustustest annetamisel. Lisatud: Goldberg-Talts, Marge. Seadusemuudatus pärsiks annetamist. Rammo, Alari. Avalikud huvid vajavad täpsustamist. EML ettepanekud tulumaksuseaduse § 11 muutmise kohta

  9. Lasteteater - mis see on? / intervjueerinud Kadi Herkül, Margot Visnap

    Index Scriptorium Estoniae

    1996-01-01

    Vastavad J. Allik, J. Põldma, I. Ever, R. Baskin, P. Pedajas, A. Vaarik, E. Eespäev, P. Tammearu, A. Tommingas, E. Nüganen, P. Jalakas, T. Tõnis, K. Saldre, J. Lumiste, H. Andersen, M. Ramløse, R.-L. Seilo

  10. Rannus mängitakse suvel Barbara lugu

    Index Scriptorium Estoniae

    2007-01-01

    Augustis on Rannus näitlejate ja näitejuhtide suvekool, mille tipphetk on ühine vabaõhuetendus "Barbara lugu", lavastajaks Jüri Lumiste. Artiklis ka lühidalt Barbara von Tiesenhuseni, kes oli Rannu lossi Tiesenhusenite 12 lapsest noorim, saatusest

  11. Ülakorrusel tukub lunastaja, all ukerdab komöödia / Pille-Riin Purje

    Index Scriptorium Estoniae

    Purje, Pille-Riin, 1963-

    2006-01-01

    Eesti teatrites lavastatud komöödiatest - Karoly Szakonyi "Saateviga" Marko Matvere lavastuses Ugalas, Neil Simoni "Sekstett a la carte" Jüri Lumiste lavastuses Vanemuises, "Täismäng" Ingomar Vihmari lavastuses Rakvere Teatris, Geraldine Aroni "Minu oivaline abielu" Kaie Mihkelsoni lavastuses Eesti Draamateatris

  12. Kivid sinu sees / Marika Makarova

    Index Scriptorium Estoniae

    Makarova, Marika

    2011-01-01

    Sapi- ja neerukivide tekke põhjustest, ravist nii tavameditsiini kui ka Steineri poolt loodud antroposoofilise meditsiini vahenditega ning mida saab teha, et kividest hoiduda. Nõuannavad Ida-Tallinna Keskhaigla kirurgid Rein Lumiste ja Toomas Tamm ning perearstikeskuse Medicum perearst Pille Soone

  13. [Määramised

    Index Scriptorium Estoniae

    2006-01-01

    Ametisse määramised: Kaitseliidu ülem major Raivo Lumiste; Maaväe staabi ülem kolonelleitnant Indrek Sirel; Kaitsejõudude peastaabi personaliosakonna ülem kolonelleitnant Vahur Väljamäe; 1. jalaväebrigaadi ülem kolonelleitnant Artur Tiganik; Scoutspataljoni ülem major Aivar Kokka; Kaitseväe peakaplan major Taavi Laanepere. Haridus, sõjaline kvalifikatsioon, teenistuskäik, auastmed, autasud

  14. Vabadusvõitluse veteran soovitab igale noorele aastakese Siberit / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2004-01-01

    Vt. ka Infopress, 27.02.2004, lk. 34, 131. Muuseumi "KGB kongid" loojast ja õpilasvabadusvõitlejast Päivu Kullist, kes vangistati 1950. aastal ning saadeti asumisele Siberisse. Lisatud sõnum "President autasustab Eesti iseseisvuspäeva puhul seitset ammust vabadusvõitlejat", kus ordeni saajatena on loetletud Aime Espenberg, Valev Kaska, Päivu Kull, Juhan Lumiste, Mango Daniel, Johannes Kivimäe, Lea Rebane

  15. Elu kui konstrueeritud kaos

    Index Scriptorium Estoniae

    2003-01-01

    Hardo Pajula ja Alari Purju osalesid Lõuna-Inglismaal Great Offleys toimunud rahvusvahelisel institutsionaalse ökonoomika seminaril. Vestlusest Pisa ülikooli professori Giovanni Dosi ja Mario Morroniga Itaalia sisepoliitikast ehk äri, poliitika, kuritegevuse ja meedia põimumisest. Itaalia peaministrist Silvio Berlusconist

  16. Kevadtormide õppetunnid / Anti Poolamets

    Index Scriptorium Estoniae

    Poolamets, Anti, 1971-

    2007-01-01

    Kevadtorm 2007 üldjuht kolonelleitnant Indrek Sirel, situatsioonikeskuse ülem major Alari Saega, Kaitsejõudude Peastaabi teavitusosakonna ülem major Peeter Tali, hindajate grupi ülem major Rasmus Lippur, jalaväebrigaadi staabi tagalaosakonna ülem major Ingvar Salk ning tsiviil- ja sõjalise koostöö grupi liige reservkapten Olavi Tammemägi kommenteerivad kaitseväe suurõppust Kevadtorm ning hindavad õppuse kasutegurit ja arenguperspektiive

  17. Prostate Cancer in the Metropolitan Washington DC Latino/Hispanic Community; Cultural, Linguistic and Economic Barriers to Care

    Science.gov (United States)

    2001-01-01

    AGVILAR ALARY ALBURQUERQUE ALDAVE ANEWO ALAS ALCADE ALDAYA AMIN ALATORRE ALCAIDA ALDAZ AHUERO ALATRISTE ALCAIDE ALDAZABAL ANUMADA ALA VA ALCALA...ALDEBOT AIBAR ALAVARADO ALCALAN ALDECOA A [NSA ALA VARDO ALCALDE ALDECOCEA AINZ ALAYA ALCAHIZ ALDEIS AIKZA ALAYETO ALCANTA ALDEREGUIA AIRA ALAYO ALCANTAR...ARMADO ARQUELLES ARRIAZOLA ARTEGO ARKAIZ ARQUELLO ARRIBA ARTELLAI( ARKANDARIZ ARQUER ARRIBAS ARTERO ARJ4ARIO ARQUERO ARRIERA ARTESOKA ARMAS ARQUES ARRIERO

  18. Collaboration de chercheurs québécois et béninois contre le sida ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    12 oct. 2010 ... Au Bénin, il y a 20 ans, l'épidémie de VIH/sida faisait rage, et le pays manquait de tout pour l'endiguer. Aujourd'hui, la guerre au sida n'est pas encore terminée, mais de nombreux combats ont été gagnés. Et cela, entre autres, grâce à la ténacité de chercheurs comme Michel Alary, rattaché au Centre ...

  19. Oliver Kruuda müüb salaja Kalevi ja Tere / Piret Reiljan, Kristina Traks, Virge Lahe

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 26. sept. lk. 9. Suuromanikud Oliver Kruuda, Heino Priimägi ja Aare Annus otsustasid müüa kondiitritööstuse Kalev ja piimatööstuse Tere investeerimisettevõttele Alta Capital ning keskenduda meediale ja kinnisvarale. Vt. samas: Kalevi aktsionäre oli koosolekul vaid käputäis; Finantsinspektsiooni kommentaar; Alta Capital; Diagramm: Kalev AS-i tütarfirmade käibed. Kommenteerivad Alari Purju, Heldur Meerits ja Toomas Kivimägi

  20. Org-1-dependent lineage reprogramming generates the ventral longitudinal musculature of the Drosophila heart.

    Science.gov (United States)

    Schaub, Christoph; März, Johannes; Reim, Ingolf; Frasch, Manfred

    2015-02-16

    Only few examples of transdifferentiation, which denotes the conversion of one differentiated cell type to another, are known to occur during normal development, and more often, it is associated with regeneration processes. With respect to muscles, dedifferentiation/redifferentiation processes have been documented during post-traumatic muscle regeneration in blastema of newts as well as during myocardial regeneration. As shown herein, the ventral longitudinal muscles of the adult Drosophila heart arise from specific larval alary muscles in a process that represents the first known example of syncytial muscle transdifferentiation via dedifferentiation into mononucleate myoblasts during normal development. We demonstrate that this unique process depends on the reinitiation of a transcriptional program previously employed for embryonic alary muscle development, in which the factors Org-1 (Drosophila Tbx1) and Tailup (Drosophila Islet1) are key components. During metamorphosis, the action of these factors is combined with cell-autonomous inputs from the ecdysone steroid and the Hox gene Ultrabithorax, which provide temporal and spatial specificity to the transdifferentiation events. Following muscle dedifferentiation, inductive cues, particularly from the remodeling heart tube, are required for the redifferentiation of myoblasts into ventral longitudinal muscles. Our results provide new insights into mechanisms of lineage commitment and cell-fate plasticity during development. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Scanning electron microscopy of the dorsal vessel of Panstrongylus megistus (Burmeister, 1835 (Hemiptera: Reduviidae

    Directory of Open Access Journals (Sweden)

    Nadir Francisca Sant'Anna Nogueira

    1991-03-01

    Full Text Available In this study we analyzed the microanatomy of the dorsal vessel of the triatomine Panstrongylus megistus. The organ is a tuble anatomically divided into an anterior aorta anad a posterior heart, connected to the body wall through 8 pairs of alary muscles. The heart is divided in 3 chambers by means of 2 pairs of cardiac valves. a pair of ostia can be observed in the lateral wall of each chamber. A bundle of nerve fibers was found outside the organ, running dorsally along its major axis. A group of longitudinal muscular fibers was found in the ventral portion of the vessel. The vessel was found to be lined both internally and externally by pericardial cells covered by a thin laminar membrane. Inseide the vessel the pericardial cells were disposed in layers and on the outside they formed clusters or rows.

  2. A new species of Phrynopus (Anura, Strabomantidae from Peru, with comments on the osteology of the genus

    Directory of Open Access Journals (Sweden)

    Linda Trueb

    2008-09-01

    Full Text Available A new, small species of Phrynopus is described from the eastern slopes of the Cordillera Oriental just north of the Río Huallaga in central Peru. The species resembles P. montium, but is distinguished from it and other congeners by its spatulate snout. The anterior end of the maxillary arcade is broadly rounded in dorsal view, and composed of wide premaxillae that bear extraordinarily large alary processes that are deflected posteriorly at an acute angle. The configuration of the premaxillae accounts for the wide, depressed snout in this species, which in other osteological features resembles P. montium. The osteology of Phrynopus montium is described in some detail in comparison to the new species, with theintention of establishing a baseline for future morphological studies and taxonomic descriptions of strabomantine anurans of this and related genera.

  3. Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.

    Science.gov (United States)

    Schaub, Christoph; Nagaso, Hideyuki; Jin, Hong; Frasch, Manfred

    2012-03-01

    Members of the T-Box gene family of transcription factors are important players in regulatory circuits that generate myogenic and cardiogenic lineage diversities in vertebrates. We show that during somatic myogenesis in Drosophila, the single ortholog of vertebrate Tbx1, optomotor-blind-related-gene-1 (org-1), is expressed in a small subset of muscle progenitors, founder cells and adult muscle precursors, where it overlaps with the products of the muscle identity genes ladybird (lb) and slouch (slou). In addition, org-1 is expressed in the lineage of the heart-associated alary muscles. org-1 null mutant embryos lack Lb and Slou expression within the muscle lineages that normally co-express org-1. As a consequence, the respective muscle fibers and adult muscle precursors are either severely malformed or missing, as are the alary muscles. To address the mechanisms that mediate these regulatory interactions between Org-1, Lb and Slou, we characterized distinct enhancers associated with somatic muscle expression of lb and slou. We demonstrate that these lineage- and stage-specific cis-regulatory modules (CRMs) bind Org-1 in vivo, respond to org-1 genetically and require T-box domain binding sites for their activation. In summary, we propose that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of these two neighboring muscle lineages. Cross-repression between slou and lb and combinatorial activation of lineage-specific targets by Org-1-Slou and Org-1-Lb, respectively, then leads to the distinction between the two lineages. These findings provide new insights into the regulatory circuits that control the proper pattering of the larval somatic musculature in Drosophila.

  4. In vitro viability effects on apheresis and buffy-coat derived platelets administered through infusion pumps

    Directory of Open Access Journals (Sweden)

    Sandgren P

    2014-12-01

    Full Text Available Per Sandgren,1,2 Veronica Berggren,3 Carl Westling,1,2 Viveka Stiller1 1Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 2Department of Laboratory Medicine, Karolinska Institutet, 3Department of Neonatology, Karolinska University Hospital, Stockholm, SwedenBackground: Different infusion pump systems as well as gravity infusion have been widely used in neonatal transfusion. However, the limited number of published studies describing the use of infusion pumps on platelets illustrates the necessity for more robust data.Methods: To evaluate the potential in vitro effects on the cellular, metabolic, functional and phenotypic properties of platelets, we set up a four-arm paired study simultaneously comparing the use of different infusion pumps (Alaris® CC/GP with unexposed platelets. The platelet units (n=8 were either produced by the apheresis technique and suspended in 100% plasma or derived from buffy coats to yield platelet units stored in approximately 30% plasma and 70% SSP+. Fresh and 5-day old platelets were tested.Results: Regardless of the production system or storage time used, no significant differences were observed in glucose and lactate concentration, pH, adenosine triphosphate levels, response to extent of shape change, hypotonic shock response reactivity, and CD62P expression. Similarly, no differences were observed in expression of the conformational epitope on glycoprotein IIb/IIIa, determined using procaspase-activating compound 1, or in the expression of CD42b and platelet-endothelial cell adhesion molecule-1 in a comparison between platelets administered through infusion pumps versus unexposed platelets.Conclusion: Using Alaris CC/GP infusion pumps had no influence on the cellular, functional, and phenotypic in vitro properties of platelets. This fact seems not to be affected by different production systems or storage time.Keywords: platelets, neonatal platelet transfusion

  5. Smart pumps and random safety audits in a Neonatal Intensive Care Unit: a new challenge for patient safety.

    Science.gov (United States)

    Bergon-Sendin, Elena; Perez-Grande, Carmen; Lora-Pablos, David; Moral-Pumarega, María Teresa; Melgar-Bonis, Ana; Peña-Peloche, Carmen; Diezma-Rodino, Mercedes; García-San Jose, Lidia; Cabañes-Alonso, Esther; Pallas-Alonso, Carmen Rosa

    2015-12-11

    Random safety audits (RSA) are a safety tool enabling prevention of adverse events, but they have not been widely used in hospitals. The aim of this study was to use RSAs to assess and compare the frequency of appropriate use of infusion pump safety systems in a Neonatal Intensive Care Unit (NICU) before and after quality improvement interventions and to analyse the intravenous medication programming data. Prospective, observational study comparing the frequency of appropriate use of Alaris® CC smart pumps through RSAs over two periods, from 1 January to 31 December 2012 and from 1 November 2014 to 31 January 2015. Appropriate use was defined as all evaluated variables being correctly programmed into the same device. Between the two periods they were established interventions to improve the use of pumps. The information recorded at the pumps with the new security system, also extracted for one year. Fifty-two measurements were collected during the first period and 160 measurements during the second period. The frequency of appropriate use was 73.13 % (117/160) in the second period versus 0 % (0/52) in the first period (p pumps in the NICU. The improvement strategies were effective for improving appropriate use and programming of the intravenous medication infusion pumps in our NICU.

  6. The proctolin gene and biological effects of proctolin in the blood-feeding bug, Rhodnius prolixus.

    Directory of Open Access Journals (Sweden)

    Ian eOrchard

    2011-10-01

    Full Text Available We have reinvestigated the possible presence or absence of the pentapeptide proctolin in Rhodnius prolixus and report here the cloning of the proctolin cDNA. The transcript is highly expressed in the central nervous system (CNS with some low expression associated with peripheral tissues. The proctolin prepropeptide encodes a single copy of proctolin along with a proctolin-precursor-associated peptide. We have biochemically identified proctolin in CNS extracts and shown its distribution using proctolin-like immunoreactivity. Immunostained processes are found on the salivary glands, female and male reproductive organs, and heart and associated alary muscles. Proctolin-like immunoreactive bipolar neurons are found on the lateral margins of the common oviduct and bursa. Proctolin is biologically active on R. prolixus tissues, stimulating increases in contraction of anterior midgut and hindgut muscles, and increasing heartbeat frequency. Contrary to the previous suggestion that proctolin is absent from R. prolixus, proctolin is indeed present and biologically active in this medically-important bug.

  7. Anestesia venosa total com infusão alvo-controlada de remifentanil e propofol para ablação de fibrilação atrial Anestesia venosa total con infusión objeto-controlada de remifentanil y propofol para ablación de la fibrilación atrial Total intravenous anesthesia with target-controlled infusion of remifetanil and propofol for ablation of atrial fibrillation

    Directory of Open Access Journals (Sweden)

    Fernando Squeff Nora

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A ablação de fibrilação atrial (FA é um procedimento novo em nosso meio, embora seja comum em outros centros. A escolha da anestesia, monitores e cuidados anestesiológicos para esse procedimento, realizado fora do bloco cirúrgico, não tem sido descrita. O objetivo deste relato foi descrever uma técnica de anestesia para a realização de ablação de FA. RELATO DO CASO: Paciente feminina, 49 anos, 73 kg, 155 cm, ASA II por hipertensão arterial sistêmica. A monitorização constou de eletrocardiograma com 12 derivações, oximetria de pulso, frequência cardíaca, eletroencefalografia bispectral para medidas de BIS, taxa de supressão (SR e SEF95 e pressão arterial média (PAM. A indução anestésica foi realizada com propofol por via venosa, em infusão alvo-controlada (IAC, com alvo regulado em 4 µg.mL-1, remifentanil por via venosa, em IAC, com alvo de 3 ng.mL¹, e rocurônio por via venosa em bolus na dose de 0,2 mg.kg-1. O modelo farmacocinético de propofol utilizado foi o descrito por Marsh e incorporado à bomba de propofol PFS®. O modelo farmacocinético de remifentanil utilizado foi o descrito por Minto e incorporado à bomba de infusão Alaris PK®. As concentrações, no local efetor ou biofase, corresponderam às informações obtidas através das bombas de infusão e representaram medidas preditivas das concentrações de ambos os fármacos nos respectivos locais de ação. As concentrações de propofol e de remifentanil foram reguladas de acordo com o BIS e a PAM, respectivamente. CONCLUSÕES: A anestesia venosa total para ablação de FA pode ser uma opção segura, levando-se em conta que não há alteração da eletrofisiologia das vias acessórias. A literatura é escassa a este respeito e novas publicações poderão ou não justificar esta modalidade de anestesia durante ablação de FA.JUSTIFICATIVA Y OBJETIVOS: La ablación de fibrilación atrial (FA es un procedimiento nuevo en

  8. Power plants 2009. Lectures

    International Nuclear Information System (INIS)

    2009-01-01

    Within the Annual Conference 2009 of the VGB PowerTech e.V. (Essen, Federal Republic of Germany) from 23rd to 25th May, 2009, in Lyon (France) the following lectures were held: (1) Electricity demand, consequences of the financial and economic crisis - Current overview 2020 for the EU-27 (Hans ten Berge); (2) Status and perspectives of the electricity generation mix in France (Bernard Dupraz); (3) European electricity grid - status and perspective (Dominique Maillard); (4) Technologies and acceptance in the European energy market (Gordon MacKerran); (5) EPR construction in Finland, China, France, (Claude Jaouen); (6) EPR Flamanville 3: A project on the path towards nuclear revival (Jacques Alary); (7) Worldwide nuclear Revival and acceptance (Luc Geraets); (8) An overview on the status of final disposal of radioactive wastes worldwide (Piet Zuidema); (9) Who needs pumped storage plants? PSP are partner to grid stability and renewable energies (Hans-Christoph Funke); (10) Sustainable use of water resources to generate electricity safely and efficiently (Patrick Tourasse); (11) The growth strategy of RWE Innogy - Role of RES in RWE strategy (Fritz Vahrenholt); (12) Solar technologies towards grid parity - key factors and timeframe (G. Gigliucci); (13) Overview on CCS technologies and results of Vattenfalls oxyfuel pilot plant (Philippe Paelinck); (14) Development perspectives of lignite-based IGCC-plants with CCS (Dietmar Keller); (15) Post combustion capture plants - concept and plant integration (Wolfgang Schreier); (16) CCS fossil power generation in a carbon constraint world (Daniel Hofmann); (17) CEZ group strategy in Central and South Eastern Europe (Jan Zizka); (18) Strategy and projects of DONG Energy (Jens Erik Pedersen); (19) E.ON coal-based power generation of the future - The highly efficient power plant and downstream separation of carbon dioxide (Gerhard Seibel); (20) Final sage of first supercritical 460 MW e l. CFB Boiler construction - firs

  9. Platelet transfusion in chemotherapy patients: comparison of the effect of intravenous infusion pumps versus gravity transfusion.

    Science.gov (United States)

    Meess, A

    2015-01-01

    Platelet concentrates are given to patients suffering with severe thrombocytopenia usually by a gravity transfusion procedure. Increasing patient numbers that are in need of this treatment increase the pressure on hospital staff and space. In order to combat time issues, the use of medical devices such as intravenous infusion pumps are thought to be beneficial for time and simultaneously for safety in transfusion practices. By using infusion pumps, platelet concentrates can be transfused in less time and provide accurate volume measurements. Manufacturers of infusion pumps claim that these devices are safe to be used for blood products including platelet concentrates. However, published studies were performed on older models and newer devices are on the market now. The purpose of this study is to evaluate infusion pumps, which are claimed to be suitable for blood products and to investigate the impact the pumps had on platelets. Furthermore, the study revealed if the intravenous infusion pumps are safe to be used for platelet transfusion as claimed by manufacturers. A simulated transfusion was performed using the Carefusion Alaris GP Plus volumetric pump and Fresenius Kabi Volumat Agilia infusion pump. Samples were taken from expired platelet concentrates before and after passage through the pump. All samples were investigated for full blood count that included platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and a plateletcrit (PCT). The samples were then centrifuged to achieve platelet-poor plasma and then tested for lactate dehydrogenase (LDH). A power calculation performed on the statistical power analysis program G*power indicated a requirement of 82 samples for a power of 80%. Statistical analysis was performed with the IBM SPSS statistic software. A paired sample t-test was used to calculate mean, standard deviation and P values for the infusion pumps used. The Wilcoxon Signed Rank Test was used to evaluate results that had a non