Cloning and expression profiling of the PacSnRK2 and PacPP2C gene families during fruit development, ABA treatment, and dehydration stress in sweet cherry.

Science.gov (United States)

Shen, Xinjie; Guo, Xiao; Zhao, Di; Zhang, Qiang; Jiang, Yuzhuang; Wang, Yantao; Peng, Xiang; Wei, Yan; Zhai, Zefeng; Zhao, Wei; Li, Tianhong

2017-10-01

Plant SNF1-related protein kinase 2 (SnRK2) and protein phosphatase 2C (PP2C) family members are core components of the ABA signal transduction pathway. SnRK2 and PP2C proteins have been suggested to play crucial roles in fruit ripening and improving plant tolerance to drought stress, but supporting genetic information has been lacking in sweet cherry (Prunus avium L.). Here, we cloned six full-length SnRK2 genes and three full-length PP2C genes from sweet cherry cv. Hong Deng. Quantitative PCR analysis revealed that PacSnRK2.2, PacSnRK2.3, PacSnRK2.6, and PacPP2C1-3 were negatively regulated in fruits in response to exogenous ABA treatment, PacSnRK2.4 and PacSnRK2.5 were upregulated, and PacSnRK2.1 expression was not affected. The ABA treatment also significantly promoted the accumulation of anthocyanins in sweet cherry fruit. The expression of all PacSnRK2 and PacPP2C genes was induced by dehydration stress, which also promoted the accumulation of drought stress signaling molecules in the sweet cherry fruits, including ABA, soluble sugars, and anthocyanin. Furthermore, a yeast two-hybrid analysis demonstrated that PacPP2C1 interacts with all six PacSnRK2s, while PacPP2C3 does not interact with PacSnRK2.5. PacPP2C2 does not interact with PacSnRK2.1 or PacSnRK2.4. These results indicate that PacSnRK2s and PacPP2Cs may play a variety of roles in the sweet cherry ABA signaling pathway and the fruit response to drought stress. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Arabidopsis decuple mutant reveals the importance of SnRK2 kinases in osmotic stress responses in vivo

KAUST Repository

Fujii, Hiroaki

2011-01-10

Osmotic stress associated with drought or salinity is a major factor that limits plant productivity. Protein kinases in the SNF1-related protein kinase 2 (SnRK2) family are activated by osmotic stress, suggesting that the kinases are involved in osmotic stress signaling. However, due to functional redundancy, their contribution to osmotic stress responses remained unclear. In this report, we constructed an Arabidopsis line carrying mutations in all 10 members of the SnRK2 family. The decuple mutant snrk2.1/2/3/4/5/6/7/8/9/10 grew poorly under hyperosmotic stress conditions but was similar to the wild type in culture media in the absence of osmotic stress. The mutant was also defective in gene regulation and the accumulation of abscisic acid (ABA), proline, and inositol 1,4,5-trisphosphate under osmotic stress. In addition, analysis of mutants defective in the ABA-activated SnRK2s (snrk2.2/3/6) and mutants defective in the rest of the SnRK2s (snrk2.1/4/5/7/8/9/10) revealed that SnRK2s are a merging point of ABA-dependent and -independent pathways for osmotic stress responses. These results demonstrate critical functions of the SnRK2s in mediating osmotic stress signaling and tolerance.

Improved syntheses of high hole mobility phthalocyanines: A case of steric assistance in the cyclo-oligomerisation of phthalonitriles

Directory of Open Access Journals (Sweden)

Daniel J. Tate

2012-01-01

Full Text Available It has been shown that the base-initiated cyclo-oligomerisation of phthalonitriles is favoured by bulky α-substituents making it possible to obtain the metal-free phthalocyanine directly and in high yield. The phthalocyanine with eight α-isoheptyl substituents gives a high time-of-flight hole mobility of 0.14 cm2·V−1·s−1 within the temperature range of the columnar hexagonal phase, that is 169–189 °C.

The Protein Kinase SmSnRK2.6 Positively Regulates Phenolic Acid Biosynthesis in Salvia miltiorrhiza by Interacting with SmAREB1.

Science.gov (United States)

Jia, Yanyan; Bai, Zhenqing; Pei, Tianlin; Ding, Kai; Liang, Zongsuo; Gong, Yuehua

2017-01-01

Subclass III members of the sucrose non-fermenting-1-related protein kinase 2 (SnRK2) play essential roles in both the abscisic acid signaling and abiotic stress responses of plants by phosphorylating the downstream ABA-responsive element (ABRE)-binding proteins (AREB/ABFs). This comprehensive study investigated the function of new candidate genes, namely SmSnRK2.3 , SmSnRK2.6 , and SmAREB1 , with a view to breeding novel varieties of Salvia miltiorrhiza with improved stress tolerance stresses and more content of bioactive ingredients. Exogenous ABA strongly induced the expression of these genes. PlantCARE predicted several hormones and stress response cis -elements in their promoters. SmSnRK2.6 and SmAREB1 showed the highest expression levels in the leaves of S. miltiorrhiza seedlings, while SmSnRK2.3 exhibited a steady expression in their roots, stems, and leaves. A subcellular localization assay revealed that both SmSnRK2.3 and SmSnRK2.6 were located in the cell membrane, cytoplasm, and nucleus, whereas SmAREB1 was exclusive to the nucleus. Overexpressing SmSnRK2.3 did not significantly promote the accumulation of rosmarinic acid (RA) and salvianolic acid B (Sal B) in the transgenic S. miltiorrhiza hairy roots. However, overexpressing SmSnRK2.6 and SmAREB1 increased the contents of RA and Sal B, and regulated the expression levels of structural genes participating in the phenolic acid-branched and side-branched pathways, including SmPAL1 , SmC4H , Sm4CL1 , SmTAT , SmHPPR , SmRAS , SmCHS , SmCCR , SmCOMT , and SmHPPD . Furthermore, SmSnRK2.3 and SmSnRK2.6 interacted physically with SmAREB1. In summary, our results indicate that SmSnRK2.6 is involved in stress responses and can regulate structural gene transcripts to promote greater metabolic flux to the phenolic acid-branched pathway, via its interaction with SmAREB1 , a transcription factor. In this way, SmSnRK2.6 contributes to the positive regulation of phenolic acids in S. miltiorrhiza hairy roots.

The Protein Kinase SmSnRK2.6 Positively Regulates Phenolic Acid Biosynthesis in Salvia miltiorrhiza by Interacting with SmAREB1

Directory of Open Access Journals (Sweden)

Yanyan Jia

2017-08-01

Full Text Available Subclass III members of the sucrose non-fermenting-1-related protein kinase 2 (SnRK2 play essential roles in both the abscisic acid signaling and abiotic stress responses of plants by phosphorylating the downstream ABA-responsive element (ABRE-binding proteins (AREB/ABFs. This comprehensive study investigated the function of new candidate genes, namely SmSnRK2.3, SmSnRK2.6, and SmAREB1, with a view to breeding novel varieties of Salvia miltiorrhiza with improved stress tolerance stresses and more content of bioactive ingredients. Exogenous ABA strongly induced the expression of these genes. PlantCARE predicted several hormones and stress response cis-elements in their promoters. SmSnRK2.6 and SmAREB1 showed the highest expression levels in the leaves of S. miltiorrhiza seedlings, while SmSnRK2.3 exhibited a steady expression in their roots, stems, and leaves. A subcellular localization assay revealed that both SmSnRK2.3 and SmSnRK2.6 were located in the cell membrane, cytoplasm, and nucleus, whereas SmAREB1 was exclusive to the nucleus. Overexpressing SmSnRK2.3 did not significantly promote the accumulation of rosmarinic acid (RA and salvianolic acid B (Sal B in the transgenic S. miltiorrhiza hairy roots. However, overexpressing SmSnRK2.6 and SmAREB1 increased the contents of RA and Sal B, and regulated the expression levels of structural genes participating in the phenolic acid-branched and side-branched pathways, including SmPAL1, SmC4H, Sm4CL1, SmTAT, SmHPPR, SmRAS, SmCHS, SmCCR, SmCOMT, and SmHPPD. Furthermore, SmSnRK2.3 and SmSnRK2.6 interacted physically with SmAREB1. In summary, our results indicate that SmSnRK2.6 is involved in stress responses and can regulate structural gene transcripts to promote greater metabolic flux to the phenolic acid-branched pathway, via its interaction with SmAREB1, a transcription factor. In this way, SmSnRK2.6 contributes to the positive regulation of phenolic acids in S. miltiorrhiza hairy roots.

Gamma radiation induced oxidative stress and apoptosis inhibiting properties of bacterial secondary metabolite RK-IP-006.G in J774A.1 murine cell line

International Nuclear Information System (INIS)

Malhotra, Poonam; Gupta, Ashutosh K.; Singh, Praveen K.; Chhachhia, Neha; Singh, Shravan K.; Raj Kumar

2014-01-01

Redox imbalance due to radiation induced oxidation of vital bio-macromolecules activates inflammatory response cascade leading to cell death. In present study, bacterial secondary metabolite, RK-IP-006.G, was evaluated for its oxidative stress and apoptosis inhibiting activities in irradiated J774A.1 murine macrophage cell line. Radiation induced intracellular ROS generation and its inhibition upon RK-IP-006.G pretreatment was estimated using 2',7'dichlorodihydroflurescein diacetate (DCFDA). Modulation in mitochondrial membrane potential (MMP) in irradiated cells and its protection by RK-IP-006.G pretreatment was evaluated using Rhodamine-123. Modulation in protein expression in irradiated and RK-IP-006.G treated J774A.1 cells was assessed by SDS-PAGE. Compensatory effect of RK-IP-006.G treatment on TNF-α expression in irradiated cells was estimated using ELISA assay. APO-BrDU assay was performed to evaluate radiation-induced apoptosis in irradiated cells. Radiation-induced cell damage and protective ability of RK-IP-006.G was also evaluated using Differential Interference Contrast Microscopy. Results of the study indicated significant (p< 0.05) decrease in DCFDA fluorescence in irradiated cells that were pretreated (∼2h) with RK-IP-006.G (0.25 μg/ml) as compared to irradiated cells. Similarly, significant (p<0.05) decrease in MMP was observed in irradiated cells pretreated with RK-IP-006.G (0.25 μg/ml) as compared to only irradiated cells at 1 h time point. SDS-PAGE analysis clearly demonstrated up-regulation of some prominent proteins in irradiated cells pretreated with RK-IP-006.G at 2-4h after treatment as compared to irradiated control. Significant (p<0.05) down regulation in TNF-α expression was observed in irradiated cells that pretreated with RK-IP-006.G compared to irradiated controls. APO-BrDU assay revealed significant reduction in apoptosis in irradiated cells pretreated with RK-IP-006.G when compared to irradiated control. The findings

Transcriptional regulation of SlPYL, SlPP2C, and SlSnRK2 gene families encoding ABA signal core components during tomato fruit development and drought stress.

Science.gov (United States)

Sun, Liang; Wang, Yan-Ping; Chen, Pei; Ren, Jie; Ji, Kai; Li, Qian; Li, Ping; Dai, Sheng-Jie; Leng, Ping

2011-11-01

In order to characterize the potential transcriptional regulation of core components of abscisic acid (ABA) signal transduction in tomato fruit development and drought stress, eight SlPYL (ABA receptor), seven SlPP2C (type 2C protein phosphatase), and eight SlSnRK2 (subfamily 2 of SNF1-related kinases) full-length cDNA sequences were isolated from the tomato nucleotide database of NCBI GenBank. All SlPYL, SlPP2C, and SlSnRK2 genes obtained are homologous to Arabidopsis AtPYL, AtPP2C, and AtSnRK2 genes, respectively. Based on phylogenetic analysis, SlPYLs and SlSnRK2s were clustered into three subfamilies/subclasses, and all SlPP2Cs belonged to PP2C group A. Within the SlPYL gene family, SlPYL1, SlPYL2, SlPYL3, and SlPYL6 were the major genes involved in the regulation of fruit development. Among them, SlPYL1 and SlPYL2 were expressed at high levels throughout the process of fruit development and ripening; SlPYL3 was strongly expressed at the immature green (IM) and mature green (MG) stages, while SlPYL6 was expressed strongly at the IM and red ripe (RR) stages. Within the SlPP2C gene family, the expression of SlPP2C, SlPP2C3, and SlPP2C4 increased after the MG stage; SlPP2C1 and SlPP2C5 peaked at the B3 stage, while SlPP2C2 and SlPP2C6 changed little during fruit development. Within the SlSnRK2 gene family, the expression of SlSnRK2.2, SlSnRK2.3, SlSnRK2.4, and SlSnRK2C was higher than that of other members during fruit development. Additionally, most SlPYL genes were down-regulated, while most SlPP2C and SlSnRK2 genes were up-regulated by dehydration in tomato leaf.

Functional Characterization of TaSnRK2.8 Promoter in Response to Abiotic Stresses by Deletion Analysis in Transgenic Arabidopsis

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Hongying Zhang

2017-07-01

Full Text Available Drought, salinity, and cold are the major factors limiting wheat quality and productivity; it is thus highly desirable to characterize the abiotic-stress-inducible promoters suitable for the genetic improvement of plant resistance. The sucrose non-fermenting 1-related protein kinase 2 (SnRK2 family genes show distinct regulatory properties in response to abiotic stresses. The present study characterized the approximately 3000-bp upstream sequence (the 313 bp upstream of the ATG was the transcription start site of the Triticum aestivum TaSnRK2.8 promoter under abscisic acid (ABA and abiotic stresses. Four different-length 5′ deletion fragments of TaSnRK2.8 promoter were fused with the GUS reporter gene and transformed into Arabidopsis. Tissue expression analysis showed that the TaSnRK2.8 promoter region from position -1481 to -821 contained the stalk-specific elements, and the region from position -2631 to -1481 contained the leaf- and root-specific elements. In the ABA-treated seedlings, the deletion analysis showed that the TaSnRK2.8 promoter region from position -821 to -2631 contained ABA response elements. The abiotic stress responses of the TaSnRK2.8 promoter derivatives demonstrated that they harbored abiotic-stress response elements: the region from position -821 to -408 harbored the osmotic-stress response elements, whereas the region from position -2631 to -1481 contained the positive regulatory motifs and the region from position -1481 to -821 contained the leaf- and stalk-specific enhancers. Further deletion analysis of the promoter region from position -821 to -408 indicated that a 125-bp region from position -693 to -568 was required to induce an osmotic-stress response. These results contribute to a better understanding of the molecular mechanisms of TaSnRK2.8 in response to abiotic stresses, and the TaSnRK2.8 promoter seems to be a candidate for regulating the expression of abiotic stress response genes in transgenic plants.

Evaluation for intravenous, arterial and local infusion of a hypoxic cell radiosensitizer RK28 on rabbit VX2 tumor system

International Nuclear Information System (INIS)

Kuramitsu, Tatsuya

1993-01-01

We evaluated the radiosensitizing effect of intraarterial, intravenous and local infusion of a hypoxic cell radiosensitizer RK28 on rabbit VX2 tumor system. Six rabbits were treated in each infusion group. VX2 tumor was implanted in the left hind leg. Tumor grown up to 3 cm in diameter was treated with 15 Gy of X-ray irradiation just after infusion of radiosensitizer RK28 (80 mg/kg.b.w.). Intratumoral and serum mean concentration of RK28 and its metabolites were measured. Tumor regression curve and survival time were analyzed. The following results were obtained. Mean concentration of RK28 was about 2.5 times greater in local infusion and 1.5 times in intraarterial infusion than in intravenous infusion. Significant regression of tumor was obtained in intraarterial infusion (p<0.01). There was no significant difference in survival time. These data suggest that the usefulness of intraarterial infusion of RK28 for local control using intraoperative radiation therapy and brachytherapy. (author)

Isolation and characterization of the TaSnRK2.10 gene and its association with agronomic traits in wheat (Triticum aestivum L..

Directory of Open Access Journals (Sweden)

Zhao-Gui Zhang

Full Text Available Sucrose non-fermenting 1-related protein kinases (SnRKs comprise a major family of signaling genes in plants and are associated with metabolic regulation, nutrient utilization and stress responses. This gene family has been proposed to be involved in sucrose signaling. In the present study, we cloned three copies of the TaSnRK2.10 gene from bread wheat on chromosomes 4A, 4B and 4D. The coding sequence (CDS is 1086 bp in length and encodes a protein of 361 amino acids that exhibits functional domains shared with SnRK2s. Based on the haplotypes of TaSnRK2.10-4A (Hap-4A-H and Hap-4A-L, a cleaved amplified polymorphic sequence (CAPS marker designated TaSnRK2.10-4A-CAPS was developed and mapped between the markers D-1092101 and D-100014232 using a set of recombinant inbred lines (RILs. The TaSnRK2.10-4B alleles (Hap-4B-G and Hap-4B-A were transformed into allele-specific PCR (AS-PCR markers TaSnRK2.10-4B-AS1 and TaSnRK2.10-4B-AS2, which were located between the markers D-1281577 and S-1862758. No diversity was found for TaSnRK2.10-4D. An association analysis using a natural population consisting of 128 winter wheat varieties in multiple environments showed that the thousand grain weight (TGW and spike length (SL of Hap-4A-H were significantly higher than those of Hap-4A-L, but pant height (PH was significantly lower.

Lectin receptor kinase LecRK-b2 localizes to plasma membrane and ...

African Journals Online (AJOL)

STORAGESEVER

2009-07-20

Jul 20, 2009 ... Furthermore, the recombinant LecRK-b2 protein exhibited autophosphorylation ... absence of ligand (Giranton et al., 2000; Shimosato et al.,. 2007), while some ..... Elicitin and Mediates INF1-induced Cell Death. Planta, 228: ...

Preparation and evaluation of suppositories for RK-28 (a new radiosensitizer) using rabbits

International Nuclear Information System (INIS)

Kim, Nak-Seo; Umejima, Hiroyuki; Miyata, Kaori; Okubo, Mayumi; Goto, Shigeru; Kato, Tetsuo; Mikami, Yukio; Sagitani, Hiromichi; Inoue, Haruyuki.

1994-01-01

The pharmacokinetics of RK-28 [1-(4-hydroxy-2-butenoxy)methyl-2-nitroimidazole], a new hypoxic cell radiosensitizer, was studied following intravenous, oral, and rectal administration to rabbits. After an oral administration of RK-28 solution, the plasma concentration of RK-28 was considerably lower than that after intravenous administration through all time periods, and the absolute bioavailability was a mere 4.2%. It was presumed that a specific acid-catalyzed decomposition of RK-28 progressed in the stomach, and also, the absorbed RK-28 suffered first-pass effects in the liver. In contrast, the absolute bioavailability following the rectal administration of a solidified RK-28 suppository preparation was significantly increased in comparison with that obtained by other administration routes. Also, RK-28 emulsion suppositories were prepared by emulsifying various amounts of the drug with 1-hexadecanol and hydrogenated castor oil (HCO 60) at 80degC, and these were administered into the rabbit rectum. The resulting absolute bioavailability was 91% for the RK-28 emulsion suppository and 86.9% for an RK-28 emulsion suppository containing small amounts of Eudispert hv. These values were better than those in rats. The rectal administration of the RK-28 emulsion suppository containing small amounts of Eudispert hv showed a preferable plasma concentration-time pattern that reflects on radiation therapy. (author)

Preparation and evaluation of suppositories for RK-28 (a new radiosensitizer) using rabbits

Energy Technology Data Exchange (ETDEWEB)

Kim, Nak-Seo; Umejima, Hiroyuki; Miyata, Kaori; Okubo, Mayumi; Goto, Shigeru (Kyushu Univ., Fukuoka (Japan). Faculty of Pharmaceutical Sciences); Kato, Tetsuo; Mikami, Yukio; Sagitani, Hiromichi; Inoue, Haruyuki

1994-05-01

The pharmacokinetics of RK-28 [1-(4-hydroxy-2-butenoxy)methyl-2-nitroimidazole], a new hypoxic cell radiosensitizer, was studied following intravenous, oral, and rectal administration to rabbits. After an oral administration of RK-28 solution, the plasma concentration of RK-28 was considerably lower than that after intravenous administration through all time periods, and the absolute bioavailability was a mere 4.2%. It was presumed that a specific acid-catalyzed decomposition of RK-28 progressed in the stomach, and also, the absorbed RK-28 suffered first-pass effects in the liver. In contrast, the absolute bioavailability following the rectal administration of a solidified RK-28 suppository preparation was significantly increased in comparison with that obtained by other administration routes. Also, RK-28 emulsion suppositories were prepared by emulsifying various amounts of the drug with 1-hexadecanol and hydrogenated castor oil (HCO 60) at 80degC, and these were administered into the rabbit rectum. The resulting absolute bioavailability was 91% for the RK-28 emulsion suppository and 86.9% for an RK-28 emulsion suppository containing small amounts of Eudispert hv. These values were better than those in rats. The rectal administration of the RK-28 emulsion suppository containing small amounts of Eudispert hv showed a preferable plasma concentration-time pattern that reflects on radiation therapy. (author).

Ledernetværk i fremtidens kommuner

DEFF Research Database (Denmark)

Petersen, Egon

2008-01-01

Ledernetværk er udbredt i den offentlige sektor. 71 pct. af lederne indgår i formaliserede ledernetværksgrupper. Ledernetværk er siden 2007 sat på den personalepolitiske dagsorden i den såkaldte kvalitetsreform inden for offentlig virksomhed. Men, ledernetværkene er overraskende nok ikke koblet......". Ledernetværk er ikke en styreform, der erstatter den klassiske hierarkiske styreform i kommunerne, men er en form, der kan "agere hurtigt og fleksibelt" i forhold til skiftende behov. Ledernetværk kan tjene flere formål. Det mest almindelige formål er at professionalisere ledelse, dvs. styrke den enkelte...

Excesses of muon g−2, RD(⁎, and RK(⁎ in a leptoquark model

Directory of Open Access Journals (Sweden)

Chuan-Hung Chen

2017-11-01

Full Text Available In this study, we investigate muon g−2, RK(⁎, and RD(⁎ anomalies in a specific model with one doublet, one triplet, and one singlet scalar leptoquark (LQ. When the strict limits from the ℓ′→ℓγ, ΔB=2, Bs→μ+μ−, and B+→K+νν¯ processes are considered, it is difficult to use one scalar LQ to explain all of the anomalies due to the strong correlations among the constraints and observables. After ignoring the constraints and small couplings, the muon g−2 can be explained by the doublet LQ alone due to the mt enhancement, whereas the measured and unexpected smaller RK(⁎ requires the combined effects of the doublet and triplet LQs, and the RD and RD⁎ excesses depend on the singlet LQ through scalar- and tensor-type interactions.

Absolute Radiometric Calibration of the GÖKTÜRK-2 Satellite Sensor Using Tuz GÖLÜ (landnet Site) from Ndvi Perspective

Science.gov (United States)

Sakarya, Ufuk; Hakkı Demirhan, İsmail; Seda Deveci, Hüsne; Teke, Mustafa; Demirkesen, Can; Küpçü, Ramazan; Feray Öztoprak, A.; Efendioğlu, Mehmet; Fehmi Şimşek, F.; Berke, Erdinç; Zübeyde Gürbüz, Sevgi

2016-06-01

TÜBİTAK UZAY has conducted a research study on the use of space-based satellite resources for several aspects of agriculture. Especially, there are two precision agriculture related projects: HASSAS (Widespread application of sustainable precision agriculture practices in Southeastern Anatolia Project Region (GAP) Project) and AKTAR (Smart Agriculture Feasibility Project). The HASSAS project aims to study development of precision agriculture practice in GAP region. Multi-spectral satellite imagery and aerial hyperspectral data along with ground measurements was collected to analyze data in an information system. AKTAR aims to develop models for irrigation, fertilization and spectral signatures of crops in Inner Anatolia. By the end of the project precision agriculture practices to control irrigation, fertilization, pesticide and estimation of crop yield will be developed. Analyzing the phenology of crops using NDVI is critical for the projects. For this reason, absolute radiometric calibration of the Red and NIR bands in space-based satellite sensors is an important issue. The Göktürk-2 satellite is an earth observation satellite which was designed and built in Turkey and was launched in 2012. The Göktürk-2 satellite sensor has a resolution 2.5 meters in panchromatic and 5 meters in R/G/B/NIR bands. The absolute radiometric calibration of the Göktürk-2 satellite sensor was performed via the ground-based measurements - spectra-radiometer, sun photometer, and meteorological station- in Tuz Gölü cal/val site in 2015. In this paper, the first ground-based absolute radiometric calibration results of the Göktürk-2 satellite sensor using Tuz Gölü is demonstrated. The absolute radiometric calibration results of this paper are compared with the published cross-calibration results of the Göktürk-2 satellite sensor utilizing Landsat 8 imagery. According to the experimental comparison results, the Göktürk-2 satellite sensor coefficients for red and NIR bands

ABSOLUTE RADIOMETRIC CALIBRATION OF THE GÖKTÜRK-2 SATELLITE SENSOR USING TUZ GÖLÜ (LANDNET SITE FROM NDVI PERSPECTIVE

Directory of Open Access Journals (Sweden)

U. Sakarya

2016-06-01

Full Text Available TÜBİTAK UZAY has conducted a research study on the use of space-based satellite resources for several aspects of agriculture. Especially, there are two precision agriculture related projects: HASSAS (Widespread application of sustainable precision agriculture practices in Southeastern Anatolia Project Region (GAP Project and AKTAR (Smart Agriculture Feasibility Project. The HASSAS project aims to study development of precision agriculture practice in GAP region. Multi-spectral satellite imagery and aerial hyperspectral data along with ground measurements was collected to analyze data in an information system. AKTAR aims to develop models for irrigation, fertilization and spectral signatures of crops in Inner Anatolia. By the end of the project precision agriculture practices to control irrigation, fertilization, pesticide and estimation of crop yield will be developed. Analyzing the phenology of crops using NDVI is critical for the projects. For this reason, absolute radiometric calibration of the Red and NIR bands in space-based satellite sensors is an important issue. The Göktürk-2 satellite is an earth observation satellite which was designed and built in Turkey and was launched in 2012. The Göktürk-2 satellite sensor has a resolution 2.5 meters in panchromatic and 5 meters in R/G/B/NIR bands. The absolute radiometric calibration of the Göktürk-2 satellite sensor was performed via the ground-based measurements - spectra-radiometer, sun photometer, and meteorological station- in Tuz Gölü cal/val site in 2015. In this paper, the first ground-based absolute radiometric calibration results of the Göktürk-2 satellite sensor using Tuz Gölü is demonstrated. The absolute radiometric calibration results of this paper are compared with the published cross-calibration results of the Göktürk-2 satellite sensor utilizing Landsat 8 imagery. According to the experimental comparison results, the Göktürk-2 satellite sensor coefficients for

Ginsenoside Rk1 bioactivity: a systematic review

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Abdelrahman Elshafay

2017-11-01

Full Text Available Ginsenoside Rk1 (G-Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Out of the 156 papers identified, we retrieved 28 eligible papers in the first skimming phase of research. Several articles largely described the G-Rk1 anti-cancer activity investigating “cell viability”, “cell proliferation inhibition”, “apoptotic activity”, and “effects of G-Rk1 on G1 phase and autophagy in tumor cells” either alone or in combination with G-Rg5. Others proved that it has antiplatelet aggregation activities, anti-inflammatory effects, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis. In conclusion, G-Rk1 has a significant anti-tumor effect on liver cancer, melanoma, lung cancer, cervical cancer, colon cancer, pancreatic cancer, gastric cancer, and breast adenocarcinoma against in vitro cell lines. In vivo experiments are further warranted to confirm these effects.

Production of a conjugate between the rK346 antigen from Leishmania infantum and the horseradish peroxidase C for the detection of rK346 antibodies.

Science.gov (United States)

Rengifo-González, Juan; Medina-Mora, Yollyseth; Silva-Barrios, Sasha; Márquez-Contreras, María Elizabeth; Tibisay Ruiz, María; Cáceres, Ana J; Concepción, Juan Luis; Quiñones, Wilfredo

2016-06-01

It was designed and characterized a reporter system to be captured by an- tibodies bound to ELISA plates. The system was designed with the rK346 from Leishmania infantum, a highly antigenic and specific protein. The rK346 was coupled to the horseradish peroxidase C (HRPc) from Armoracia rusticana using glutaraldehyde or sulfo-SMCC. Gluta- raldehyde conjugation was performed in two steps. Separation of conjugates was carried out using a Sepharose S-200 in size exclusion chromatography (SEC); fractions were analyzed via HRPc activity and through ELISA plates sensitized with polyclonal anti-rK346 IgG puri- fied from rabbit serum. A heterogeneous population of conjugates rK346-HRPc was obtained with molecular weights ranging between 109.7 ± 16.5 to 67.6 ± 10.1 kDa; with rK346-HRPe stoichiometries of 1:2; 2:1; 3:1; and 2:2. Conjugation using sulfo-SMCC was carried out first by introducing -SH groups onto the HRPc using the SATA reagent and the antigen was modi- fied with sulfo-SMCC during 45 min. Separation and analysis of conjugates was performed similarly as with glutaraldehyde, resulting in a heterogeneous population of conjugates rK346- HRPc with molecular weights between 150.5 ± 22.6 to 80.0 ± 12.0 kDa; with rK346-HRPC stoichiometries of 2:1; 1:2; 2:2; and 1:3, with an increased conjugation efficiency in compari- son with glutaraldehyde. This enables sulfo-SMCC to be used as a potential reagent for cou- pling the antigen to the HRPc, to design an economic, specific and easy method to apply as a reporter system, available to assess individuals at risk and/or at early and late stages of visceral leishmaniasis.

The Preservation of Records, Knowledge and Memory (RK and M) Across Generations: Improving Our Understanding. RK and M Workshop Proceedings

International Nuclear Information System (INIS)

Gordon-Smith, Helen; Pescatore, Claudio; Schroeder, Jantine

2013-01-01

The Second Preservation of Records, Knowledge and Memory Across Generations Workshop was held 12-13 October 2012 in Issy-les-Moulineaux, France, as part of the homonymous project under the aegis of the NEA Radioactive Waste Management Committee. There were 50 participants from 11 countries representing national governments, universities, waste management agencies, safety authorities, community groups, and specialists in both the technical and social sciences. Three international organisations were also represented. The overarching goal of the workshop was to improve our understanding of the questions pertaining to the project, and the wider culture of RK and M preservation. The workshop encouraged the discussion of experience and research from project members, the wider field of radioactive waste management, and beyond that field into academia, archiving, art, and others. The underlying assumptions of the project were reconsidered and the availability of different mechanisms and models for RK and M preservation were discussed. The fundamental need for social engagement with RK and M Preservation ran through all of the themes discussed. On the first day there were three themes - 'Why Preserve RK and M', 'Conceptualising RK and M Loss', and 'How to Preserve RK and M'. 'Why Preserve RK and M' looked at the 'safety story' from the perspective of regulation, monitoring and the role of safeguards. 'Conceptualising RK and M Loss' looked at loss and recovery and 'How to Preserve RK and M' looked at mechanisms for RK and M recovery in the short and medium term. There was also a project update on the progress of the bibliography analysis. On day two, the theme of 'How to Preserve RK and M' continued, looking at the medium and long term, archives, and the pragmatic organisation of an RK and M programme. 'What to Preserve' considered the minimal set of records which should be preserved. The presentations included ongoing project studies, questionnaire analysis, academic

RK-TBA studies at the RTA test facility

International Nuclear Information System (INIS)

Lidia, S.; Anderson, D.; Eylon, S.; Henestroza, E.; Houck, T.; Reginato, L.; Vanecek, D.; Westenskow, G.

1997-01-01

Construction of a prototype RF power source based on the RK-TBA concept, called the RTA, has commenced at the Lawrence Berkeley National Laboratory. This prototype will be used to study physics, engineering, and costing issues involved in the application of the RK-TBA concept to linear colliders. The status of the prototype is presented, specifically the 1-MV, 1.2-kA induction electron gun and the pulsed power system that are in assembly. The RTA program theoretical effort, in addition to supporting the development of the prototype, has been studying optimization parameters for the application of the RK-TBA concept to higher-energy linear colliders. An overview of this work is presented. copyright 1997 American Institute of Physics

马铃薯StSnRK2.4基因的克隆及其序列特征分析%Cloning and analysis of characteristics sequence of StSnRK2 .4 gene in potatoes

Institute of Scientific and Technical Information of China (English)

李洋; 白江平; 毛娟; 王丽; 范阿棋; 张俊莲; 王蒂

2014-01-01

The cDNA sequence of StSnRK2.4 were cloned by RT-PCR from the test-tube seedling roots of common potato cultivars ‘Longshu-3’.The full sequence contained 1 083 bp and encoded 360 ami-no acids,and there were high homologies with the SnRK2 gene family of tobacco,and the homology was 95.56%.The gene was registered to GenBank (No.JX280914).The bioinformatics analysis showed that the molecular weight of SnRK2.4 was 41.49 kU,the theoretical isoelectric point was 5.52,and it had not trans-membrane domain and mainly existed in the cell nucleus containing some active sites,such as cAMP-and cGMP-dependent protein kinase phosphorylation site,Protein kinase C phosphorylation site,Casein ki-nase II phosphorylation site,Tyrosine kinase phosphorylation site and N-myristoylation site,Serine/Threo-nine protein kinases active-site and protein kinases ATP-binding region.It is suggested that the function of the gene can associate with plant resistance to adversity stress.%利用 RT-PCR技术从马铃薯普通栽培品种‘陇薯3号’试管苗根部扩增得到StSnRK2.4基因的 cDNA序列,并对其编码蛋白进行特性和结构分析.结果表明：该基因序列全长1083 bp,编码360个氨基酸,与烟草SnRK2家族基因具有较高的同源性,达95.56%,已注册该基因到 GenBank(No.JX280914)；该蛋白分子量为41.49 kU,理论等电点为5.52,是一个不跨膜的膜内蛋白,主要存在于细胞核中,含有依赖 cAMP/cGMP 蛋白激酶磷酸化、蛋白激酶C磷酸化、酪蛋白激酶Ⅱ磷酸化、酪氨酸蛋白激酶磷酸化和豆蔻酰化位点,丝氨酸/苏氨酸蛋白激酶活性位点信号序列和蛋白激酶 ATP结合区域信号序列,推测该基因功能与植物抗逆境胁迫有关.

Environmental Information System Baden-Wuerttemberg. RK UIS 2015 framework concept 2015; Umweltinformationssystem Baden-Wuerttemberg. RK UIS 2015 Rahmenkonzeption 2015

Energy Technology Data Exchange (ETDEWEB)

Weissenbach, Kurt (ed.)

2016-02-16

The Baden-Wuerttemberg Environmental Information System (UIS BW), which was set up over 30 years ago, has developed into a strategic national policy instrument for precautionary environmental and climate protection. Its importance will continue to increase as digitalisation progresses. The associated framework concept (RK UIS) has been regularly updated since 1989. The RK UIS 2015 is a fundamental revision of the last framework concept from the year 2006. The legal, technical, technical and organizational requirements that have since been amended have been incorporated and reflected in their impact on the overall conceptual framework. The RK UIS 2015 documents recommendations and development goals for adapting the UIS BW to the changed targets and general conditions. The renewed conceptual framework forms the basis for the further development of the individual UIS components. [German] Das in ueber 30 Jahren aufgebaute Umweltinformationssystem Baden-Wuerttemberg (UIS BW) hat sich zu einem strategischen Instrument der Landespolitik fuer einen vorsorgenden Umwelt- und Klimaschutz entwickelt. Seine Bedeutung wird durch die fortschreitende Digitalisierung weiter zunehmen. Die zugehoerige Rahmenkonzeption (RK UIS) wird seit 1989 regelmaessig fortgeschrieben. Mit der RK UIS 2015 liegt eine grundlegende Ueberarbeitung der letzten Rahmenkonzeption aus dem Jahr 2006 vor. Die seitdem geaenderten rechtlichen, fachlichen, technischen und organisatorischen Anforderungen wurden aufgenommen und in ihren Auswirkungen auf den konzeptionellen Gesamtrahmen reflektiert. Die RK UIS 2015 dokumentiert Empfehlungen und Entwicklungsziele fuer die Anpassung des UIS BW an die veraenderten Zielvorgaben und Rahmenbedingungen. Der erneuerte konzeptionelle Gesamtrahmen bildet die Basis fuer die Weiterentwicklung der einzelnen UIS-Komponenten.

Arabidopsis decuple mutant reveals the importance of SnRK2 kinases in osmotic stress responses in vivo

KAUST Repository

Fujii, Hiroaki; Verslues, Paul E.; Zhu, Jian-Kang

2011-01-01

Osmotic stress associated with drought or salinity is a major factor that limits plant productivity. Protein kinases in the SNF1-related protein kinase 2 (SnRK2) family are activated by osmotic stress, suggesting that the kinases are involved

Kinetic study of Escherichia coli BPPTCC-EgRK2 to produce recombinant cellulase for ethanol production from oil palm empty fruit bunch

Science.gov (United States)

Limoes, S.; Rahman, S. F.; Setyahadi, S.; Gozan, M.

2018-03-01

Oil Palm Empty Fruit Bunch (OPEFB) is an abundant biomass resource in Indonesia, which contains 46,77% (w/w) of cellulose. The high cellulose content of OPEFB can be used as a substrate for bacteria cultivation to produce cellulase. By using OPEFB as an alternative substrate, the production cost of cellulase in industrial scale can be suppressed. However, currently there are no available research that simulate a cellulase production plant design. Prior to simulating the cellulase plant design, kinetic studies of bacteria used in cultivation are needed to create an accurate simulation. In this research, kinetic studies of E. coli BPPTCC-EgRK2 growth were examined with the Monod approach to get the Monod constant (Ks) and maximum specific growth rate (μmax). This study found that E. coli BPPTCC-EgRK2 have μmax and Ks of 1.581 and 0.0709 respectively. BPPTCC-EgRK2 produced intracellular cellulase, thus gave linear correlation between cell concentration and cellulase production.

Do r/K reproductive strategies apply to human differences?

Science.gov (United States)

Rushton, J P

1988-01-01

This article discusses the r/K theory of Social Biology and how it relates to humans. The symbols r and K originate in the mathematics of population biology and refer to 2 ends of a continuum in which a compensatory exchange occurs between gamete production (the r-strategy) and longevity (the K-strategy). Both across and within species, r and K strategists differ in a suite of correlated characteristics. Humans are the most K of all. K's supposedly have a longer gestation period, a higher birthweight, a more delayed sexual maturation, a lower sex drive, and a longer life. Studies providing evidence for the expected covariation among K attributes are presented. Additional evidence for r/K theory comes from the comparison of human population known to differ in gamete production. The pattern of racial differences observed to occur in sexual behavior has also been found to exist on numerous other indices of K. For instance, there are racial differences in brain size, intelligence, and maturation rate, among others. The findings suggest that, on the average, Mongoloids are more K than Caucasoids, who in turn, are more K than Negroids. Recently conducted studies have extended the data in favor of r/K theory, and further research is currently underway, including whether r/K attributes underlie individual and social class differences in health and longevity.

Mesoporous catalysts for the synthesis of clean diesel fuels by oligomerisation of olefins

Energy Technology Data Exchange (ETDEWEB)

Catani, Roberto; Rossini, Stefano [Snamprogetti SpA, Via F. Maritano 26, 20092 , MI S. Donato Milanese (Italy); Mandreoli, Monica; Vaccari, Angelo [Dipartimento di Chimica Industriale e dei Materiali, Universita di Bologna, INSTM-UdR di Bologna, Viale del Risorgimento 4, 40136 Bologna (Italy)

2002-07-03

Si/Al MCM-41 type mesoporous compounds, as such or containing small amounts of metal (Ni, Rh or Pt), were investigated in the synthesis of clean diesel fuels by oligomerisation of orphan olefin streams. Very good catalytic performances were obtained with C{sub 4} and C{sub 5} olefins, while almost no conversion occurred with ethylene. The activity increased with increasing reaction pressure, temperature and contact time, while high Si/Al ratios had a negative effect on both activity and catalyst stability. The presence of small amount of metal inside the mesoporous structure did not significantly modify the catalytic activity, although specific effects were detected for each element. Since the evaluation of the cetane number by H-NMR gave rise to values about 20% lower than the actual value, a new and more complex algorithm is proposed to calculate the cetane number. Using the proposed algorithm, a good correlation index was found between calculated and motor values for pure compounds. Further study is necessary to move from pure compounds to experimental mixtures.

Unge og online sociale netværk

DEFF Research Database (Denmark)

Larsen, Malene Charlotte

I denne ph.d.-afhandling udforskes 12-18-årige danske børn og unges brug af et af den seneste tids nyere internetfænomener: Online sociale netværk. De såkaldte sociale netværkssider (SNS’er) er internetbaserede mødesteder, hvor brugere via personaliserede profiler kan liste hinanden som venner og...... for danske unges brug af online sociale netværk....

Pharmacokinetics of RK-28 (a new radiosensitizer) and pharmaceutical design of a suppository form using rats

International Nuclear Information System (INIS)

Kim, Nak-Seo; Umejima, Hiroyuki; Miyata, Kaori; Okubo, Mayumi; Goto, Shigeru; Kato, Tetsuo; Mikami, Yukio; Sagitani, Hiromichi; Inoue, Haruyuki.

1994-01-01

The pharmacokinetics of RK-28, a new hypoxic cell radiosensitizer, was studied in rats following its intravenous, intraportal, oral and rectal administration. The pharmaceutical design of an RK-28 suppository form was also examined. After intravenous injection, RK-28 was rapidly removed from the plasma (biological half-life of 17 min) and its area under the curve (AUC) was proportional to the amount of RK-28 administered. The absolute bioavailability of RK-28 was 59.7% for intraportal administration and 36.9% for oral administration. Following oral administration of RK-28, it seems likely that specific acid-catalyzed decomposition of RK-28 takes place in the stomach and then the absorbed RK-28 undergoes first-pass metabolism in the liver. When 'solidified RK-28 suppository,' made by solidifying molten RK-28, was inserted into the rectum, hepatic first-pass metabolism could be avoided substantially. The resulting absolute bioavailability of RK-28 increased to 75%. Furthermore, 'RK-28 emulsion suppository,' prepared by emulsifying RK-28 with 1-hexadecanol and hydrogenated castor oil (HCO 60) at 80degC, showed a plasma concentration-time curve very suitable for radiation therapy; the maximum plasma concentration was attained 30 min after rectal administration and then decreased within a short period. Administration of 'RK-28 emulsion suppository,' resulted in an absolute bioavailability of 76%. (author)

RK-TBA prototype RF source

International Nuclear Information System (INIS)

Houck, T.; Anderson, D.; Giordano, G.

1996-01-01

A prototype rf power source based on the Relativistic Klystron Two-Beam Accelerator (RK-TBA) concept is being constructed at the Lawrence Berkeley National Laboratory to study physics, engineering, and costing issues. The prototype is described and compared to a full scale design appropriate for driving the Next Linear Collider (NLC). Specific details of the induction core tests and pulsed power system are presented. The 1-MeV, 1.2-kA induction gun currently under construction is also described in detail

Sociale medier og ulovlige netværk i gymnasieskolen

DEFF Research Database (Denmark)

Tække, Jesper; Paulsen, Michael Eric

2016-01-01

Artiklen handler om spændingen mellem det lærerstyrede undervisningsfællesskab og hemmelige netværk i en gymnasieklasse. De hemmelige netværk deler resultater og opgaver gennem lukkede Facebook-grupper. Denne aktivitet ville lærerne betegne som plagieren og altså som forbudt snyd, hvis de kendte ...

Radioprotection offered by bacterial secondary metabolite RK-IP-006.G to the mice by oral route of administration

International Nuclear Information System (INIS)

Gupta, Ashutosh K.; Malhotra, Poonam; Singh, Praveen K.; Chhachhia, Neha; Singh, Shravan K.; Kumar, Raj

2014-01-01

Ionizing radiation is known to cause oxidative damage in biological system primarily by generating reactive oxygen species (ROS). Gastrointestinal system is considered one of the most radiosensitive biological systems. The most radiosensitive cells type found in the intestine are continuously proliferative crypt cells. Damage to intestinal crypt cells lead to gastrointestinal functions impairment that contribute to mortality. In the present study, whole body radioprotective efficacy of bacterial secondary metabolite RK-IP-006.G was evaluated in C57BL/6 male mice. To determine free radical scavenging properties of RK-IP-006.G 2',7'-dichlorodihydrofluorescein diacetate (DCFDA) assay was performed. Radiation induced lipid peroxidation and its inhibition by RK-IP-006.G pretreatment was assessed in intestinal tissue homogenate. To find out cellular antioxidant status of the irradiated and RK-IP- 006.G treated mice, SOD, Catalase, and Glutathion-S-Transferase activity were estimated in intestinal tissue homogenate. Anti-apoptotic and mitochondrial membrane hypopolarization effect of the RK-IP-006.G was also analyzed using fluorescent probes Acridine Orange and Rhodamine123 respectively. Results of the study demonstrated that, RK-IP-006.G pretreatment (∼2h; 150 mg/kg.b.wt. oral administration) to the lethally irradiated (9 Gy) C57BL/6 male mice contributes to >83% whole body radioprotection in mice. Significant (P>0.05%) inhibition in lipid peroxidation was observed in intestinal tissue of irradiated mice pretreated with RK-IP-006.G compared to only irradiated controls. Significant (P>0.05%) increase in antioxidant enzyme i.e. Catalase, SOD and GST activities was reported in irradiated mice pretreated with RK-IP-006.G compared to irradiated control groups. RK-IP-006.G pretreatment also found to be instrumental in inhibiting radiation induced apoptosis and mitochondrial membrane hyperpolarization. In conclusion, present study revealed that bacterial secondary

Biopsy Needle Localization and Tracking Using ROI-RK Method

Directory of Open Access Journals (Sweden)

Yue Zhao

2014-01-01

Full Text Available ROI-RK method is a biopsy needle localization and tracking method. Previous research work has proved that it has a robust performance on different series of simulated 3D US volumes. Unfortunately, in real situations, because of the strong speckle noise of the ultrasound image and the different echogenic properties of the tissues, the real 3D US volumes have more complex background than the simulated images used previously. In this paper, to adapt the ROI-RK method in real 3D US volumes, a line-filter enhancement calculation only in the ROI is added to increase the contrast between the needle and background tissue, decreasing the phenomenon of expansion of the biopsy needle due to reverberation of ultrasound in the needle. To make the ROI-RK method more stable, a self-correction system is also implemented. Real data have been acquired on an ex vivo heart of lamb. The result of the ROI-RK method shows that it is capable to localize and track the biopsy needle in real situations, and it satisfies the demand of real-time application.

ATATÜRK and TURKEY FROM AN ENGLISH DIPLOMAT’S VIEW (1933-1939 / BIR INGILIZ DIPLOMATIN GÖZÜYLE ATATÜRK ve TÜRKIYE (1933–1939

Directory of Open Access Journals (Sweden)

Dr. Esra SARIKOYUNCU DEĞERLI

2008-09-01

Full Text Available Sir Percy Loraine was an assignment to the Embassy inAnkara, with the rank of Ambassador, which he took up at the end of1933. His mission lasted till May 1939. Mentioned diplomat, duringhis mission carefully observed internal and external events of Turkeyand informed the Foreign Ministry of United Kingdom and thuscontrıbuted to the development of Turkısh and England Relatıons.Healso had good relations with Mustafa Kemal Atatürk who founder of the Turkish Republic and its first president. He filled with admirationfor Atatürk’s personality and his Turkish Revolution. As a one of theEnglish diplomat Loraine, continued to do various speeches andwriting articles about Atatürk and Turkish Republic, after his missionended in Ankara. Loraine, has been opposite of the various accusationagainst Atatürk, especially “dictatorship” and “anti-religion” issues.Because of this, he made a lot of correspond with statesman andauthor also with some formal association about Atatürk.In our study, Sir Percy Loraine’s autobiography and hisopinion about Atatürk and Turkey will be expressed to take advantageof English archives documents.

Summary Record of the Sixth Meeting of Records, Knowledge and Memory (RK and M) Across Generations

International Nuclear Information System (INIS)

2014-01-01

Preservation of Records, Knowledge and Memory (RK and M) across Generations is an initiative under the RWMC in the area of knowledge consolidation and transfer. Disposal in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating long-lived radioactive waste from the biosphere. However, there is no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. The cultural dimension of preserving RK and M is an important subject. Overall, long-term preservation of RK and M is a multidisciplinary work area in which much learning is expected over the coming years. This is the task of the RWMC's RK and M initiative. A major outcome will be a menu-driven document that - the RK and M Wiki - that will allow people to identify the elements of a strategic action plan for RK and M preservation. This document is a summary record of the Sixth Meeting of Records, Knowledge and Memory (RK and M) Across Generations. The summary is made of 8 items: 1 - Introduction (C. Pescatore): Welcome and opening remarks, Review and adoption of the agenda, Aim of this meeting, Status report, Report from RepMet meeting; 2 - Finalising Phase-II: Updating the Set of Essential Records (SER) proposal (C. Mays), Updates to the Bibliography (A. Claudel), Additions to the Glossary (S. Hotzel); 3 - Internal Wiki Workshop: The RK and M Wiki (P. Maupai), Updating your own country, organisation and regulatory requirement page, General discussion on the wiki; 4 - Strategic Articles: Presentation on Tsunami Stones paper (R. Botez); 5 - Constructing Memory: Verdun 2014 Conference; 6 - Phase-II: Discussion and final approval of Phase-II Proposal (C. Pescatore), Proposal for RWMC collective statement - Flyer on guiding principles, Calendar; 7 - Additional aspects; 8 - Review of Decisions and Closure of the Meeting, Summary of Decision and actions

Effect of fractionated radiotherapy using a hypoxic cell radiosensitizer, RK-28, on experimental murine tumor

International Nuclear Information System (INIS)

Tanaka, Shukaku

1990-01-01

The effect of a hypoxic cell radiosensitizer RK-28, on fractionated radiotherapy was studied using mice with implanted tumors. Experimental animal tumors were third generation isoplants of a mammary carcinoma which arose spontaneously in a C 3 H/He mouse. RK-28 was given to the mice at two dosages: 0.4 mg/g,b.wt. and 0.2 mg/g.b.wt. Total dose of irradiation was 20 Gy which was divided into the first 10 Gy irradiation and the second 10 Gy performed after a proper time interval such as 1, 24, 48 and 72 hours after the first 10 Gy irradiation. Tumor growth was evaluated by TGT 50 /3 times, which was defined as the time required for 50% of the tumors to regrow to the 3 times value of its initial volume. Tumor volume was measured every day and TGT 50 /3 times was calculated by logit analysis method. No significant differences were found in the TGT 50 /3 times among the groups treated by radiation alone, those treated by RK-administration alone and those without any treatment. TGT 50 value of control group without any treatment was 3.40 (days). TGT 50 value of another group treated by RK-28 alone was 3.46. and TGT 50 value of 20 Gy X-ray irradiation alone was 10.23. Under the fractionated X-ray irradiation alone, TGT 50 values of the various time interval such as 9, 14, 48 and 72 hours were 11.26, 10.42, 12.14 and 1.10. Under the combined treatment of the fractionated X-ray irradiation and RK-28 administration, TGT 50 values were 17.84, 16.42, 16.59 and 17.49. These TGT 50 /3 times values showed that RK-28 had a radiosensitizing effect when given with fractionated radiotherapy even at lower doses of RK-28 administration and radiation. Therefore, it was suggested that fractionated radiotherapy using RK-28 was useful in the cancer treatment. (author) 52 refs

Luisa Värk: olen kriitiline ja liiga ambitsioonikas / Luisa Värk ; küsitles Triin Kalter

Index Scriptorium Estoniae

Värk, Luisa, 1987-

2007-01-01

Intervjuu annab TV 3 saate "Eesti otsib superstaari" finaalis viimase võistlejana välja hääletatud Luisa Värk. Saates osalemisest. Luisa õpib Tallinna Ülikooli Balti Filmi- ja Meediakoolis helirežiid

Design, development and evaluation of rK28-based point-of-care tests for improving rapid diagnosis of visceral leishmaniasis.

Directory of Open Access Journals (Sweden)

Sowmya Pattabhi

Full Text Available BACKGROUND: Visceral leishmaniasis (VL is diagnosed by microscopic confirmation of the parasite in bone marrow, spleen or lymph node aspirates. These procedures are unsuitable for rapid diagnosis of VL in field settings. The development of rK39-based rapid diagnostic tests (RDT revolutionized diagnosis of VL by offering high sensitivity and specificity in detecting disease in the Indian subcontinent; however, these tests have been less reliable in the African subcontinent (sensitivity range of 75-85%, specificity of 70-92%. We have addressed limitations of the rK39 with a new synthetic polyprotein, rK28, followed by development and evaluation of two new rK28-based RDT prototype platforms. METHODOLOGY/PRINCIPAL FINDINGS: Evaluation of 62 VL-confirmed sera from Sudan provided sensitivities of 96.8% and 93.6% (95% CI = K28: 88.83-99.61%; K39: 84.30-98.21% and specificities of 96.2% and 92.4% (95% CI = K28: 90.53-98.95%; K39: 85.54-96.65% for rK28 and rK39, respectively. Of greater interest was the observation that individual VL sera with low rK39 reactivity often had much higher rK28 reactivity. This characteristic of the fusion protein was exploited in the development of rK28 rapid tests, which may prove to be crucial in detecting VL among patients with low rK39 antibody levels. Evaluation of two prototype lateral flow-based rK28 rapid tests on 53 VL patients in Sudan and 73 VL patients in Bangladesh provided promisingly high sensitivities (95.9% [95% CI = 88.46-99.1 in Sudan and 98.1% [95% CI = 89.93-99.95%] in Bangladesh compared to the rK39 RDT (sensitivities of 86.3% [95% CI = 76.25-93.23%] in Sudan and 88.7% [95% CI = 76.97-95.73%] in Bangladesh. CONCLUSIONS/SIGNIFICANCE: Our study compares the diagnostic accuracy of rK39 and rK28 in detecting active VL cases and our findings indicate that rK28 polyprotein has great potential as a serodiagnostic tool. A new rK28-based RDT will prove to be a valuable asset in

SABIO-RK: an updated resource for manually curated biochemical reaction kinetics

Science.gov (United States)

Rey, Maja; Weidemann, Andreas; Kania, Renate; Müller, Wolfgang

2018-01-01

Abstract SABIO-RK (http://sabiork.h-its.org/) is a manually curated database containing data about biochemical reactions and their reaction kinetics. The data are primarily extracted from scientific literature and stored in a relational database. The content comprises both naturally occurring and alternatively measured biochemical reactions and is not restricted to any organism class. The data are made available to the public by a web-based search interface and by web services for programmatic access. In this update we describe major improvements and extensions of SABIO-RK since our last publication in the database issue of Nucleic Acid Research (2012). (i) The website has been completely revised and (ii) allows now also free text search for kinetics data. (iii) Additional interlinkages with other databases in our field have been established; this enables users to gain directly comprehensive knowledge about the properties of enzymes and kinetics beyond SABIO-RK. (iv) Vice versa, direct access to SABIO-RK data has been implemented in several systems biology tools and workflows. (v) On request of our experimental users, the data can be exported now additionally in spreadsheet formats. (vi) The newly established SABIO-RK Curation Service allows to respond to specific data requirements. PMID:29092055

Murværk opmuret med vådmørtler

DEFF Research Database (Denmark)

Hansen, Klavs Feilberg

Vådmørtler benyttes i størstedelen af det murede nybyggeri. Egenskaberne af murværk opmuret med vådmørtel er i dag kun mangelfuldt dokumenteret. Denne rapport beskriver en metode til bedre dokumentation af de styrkemæssige egenskaber ved murværk opmuret med vådmørtel. Første del af rapporten genn...

SnRK1 activates autophagy via the TOR signaling pathway in Arabidopsis thaliana.

Science.gov (United States)

Soto-Burgos, Junmarie; Bassham, Diane C

2017-01-01

Autophagy is a degradation process in which cells break down and recycle their cytoplasmic contents when subjected to environmental stress or during cellular remodeling. The Arabidopsis thaliana SnRK1 complex is a protein kinase that senses changes in energy levels and triggers downstream responses to enable survival. Its mammalian ortholog, AMPK, and yeast ortholog, Snf-1, activate autophagy in response to low energy conditions. We therefore hypothesized that SnRK1 may play a role in the regulation of autophagy in response to nutrient or energy deficiency in Arabidopsis. To test this hypothesis, we determined the effect of overexpression or knockout of the SnRK1 catalytic subunit KIN10 on autophagy activation by abiotic stresses, including nutrient deficiency, salt, osmotic, oxidative, and ER stress. While wild-type plants had low basal autophagy activity in control conditions, KIN10 overexpression lines had increased autophagy under these conditions, indicating activation of autophagy by SnRK1. A kin10 mutant had a basal level of autophagy under control conditions similar to wild-type plants, but activation of autophagy by most abiotic stresses was blocked, indicating that SnRK1 is required for autophagy induction by a wide variety of stress conditions. In mammals, TOR is a negative regulator of autophagy, and AMPK acts to activate autophagy both upstream of TOR, by inhibiting its activity, and in a parallel pathway. Inhibition of Arabidopsis TOR leads to activation of autophagy; inhibition of SnRK1 did not block this activation. Furthermore, an increase in SnRK1 activity was unable to induce autophagy when TOR was also activated. These results demonstrate that SnRK1 acts upstream of TOR in the activation of autophagy in Arabidopsis.

Ölmekte Olan Türk Lehçelerini Koruma ve Yaşatma

Directory of Open Access Journals (Sweden)

Murat AYDIN

2017-09-01

Full Text Available Türk lehçeleri Doğu Avrupa’dan Sibirya ve Çin’in batısına kadar yaklaşık 250 milyon kişi tarafından konuşulan geniş bir dil ailesidir. Bu çalışmamızda öncelikle dil ölümünü, dillerin ne zaman ve nerede tehlike altında olduğunu ve özellikle Türk lehçeleri üzerinde durulmuştur. Daha sonra Türkçenin 20 farklı yazı diline ayrışmasının doğal bir sürecin sonucu mu yoksa dil planlamalarının sonucu mu olduğunu, Türk lehçeleri üzerine uygulanan dil politikalarını ve tehlike altındaki Türk lehçelerini ele alınmıştır. . Bu çalışmanın amacı, ölmek üzere olan Türk lehçelerini korumak ve yaşatmaktır. Türk lehçelerine yönelik yapılan bu çalışmada nitel araştırma yöntemlerinden betimsel tarama modeli kullanılmıştır. Çalışma evreni olarak Tofa, Duha ve Pamir Kırgızcası incelenmiştir. Yapılan araştırma sonucunda Türk lehçelerine baktığımızda çok farklı yazı dillerinin olması bilinçli bir şekilde uygulanan dil planlamalarının sonucu olduğu gerçeğini gözler önüne sermektedir. “Böl-parçala-yut” taktiğini uygulayan dış güçler emellerine ulaşmışlar ve Türk dil birliğini bozmuşlardır. Dil olmadan kültürün yaşatılması çok zordur. Türk lehçelerinin ve yazı dillerinin sayısının çok olması Türkçe adına bir zenginlik olmakla birlikte Türk dünyası birliği adına da bir engel teşkil etmektedir. Bazı Türk topluluklarının Arap alfabesi, bazılarının Latin, diğerlerinin de Kiril alfabesini kullanması bu ayrışmanın ve birbirini anlayamamanın en somut göstergesidir. Bu doğrultuda en azından birbirine yakın olan, aynı kolda ya da grupta olan lehçelerin ortak bir yazı diline geçmeleri hem kendileri adına hem de diğer lehçeler adına bir kazanç olacaktır.

[Late complications following Björk-Shiley and St. Jude Medical heart valve replacement].

Science.gov (United States)

Horstkotte, D; Körfer, R; Budde, T; Haerten, K; Schulte, H D; Bircks, W; Loogen, F

1983-05-01

Valve-related complications after Björk-Shiley mitral (n = 475), aortic (n = 424), or mitral-aortic implantation (n = 119) were compared to complications after St. Jude mitral (n = 173), aortic (n = 152), and St. Jude mitral and aortic (n = 63) replacements. The 1,018 consecutive patients with Björk-Shiley valves had been operated upon between 1974 and 1982, those with St. Jude valves between 1978 and 1982. All patients were placed on anticoagulant therapy with phenprocoumon early after operation and no significant intergroup differences in the effectiveness of the anticoagulant therapy were found. At a comparable follow-up time of approximately 23 months, 24 major thromboembolic episodes were observed after Björk-Shiley mitral (BSM) and 3 after St. Jude mitral valve implantation (SJM), corresponding to a thromboembolic rate of 2.82/100 patient years with BSM and 0.93/100 patient years with SJM. After aortic valve replacements, 1.93 events in 100 patient years occurred after Björk-Shiley aortic (BSA) and 0.73 after St. Jude aortic implantation (SJA). In patients with double valve replacements, these rates were 3.2 (BSM + BSA) and 0.88 (SJM + SJA), respectively. The cerebral vessels were involved in 52% and the arteries of the extremities in 22% of these major events. Six Björk-Shiley prostheses had to be replaced because of valve thrombosis. The overall incidence of severe hemorrhagic complications was 2.94/100 patient years in BSM and 1.79 in SJM. After aortic valve replacement, we found rates of 1.80/100 patient years (BSA) and 2.57/100 patient years (SJA), respectively. Intravascular hemolysis no longer seems to be a significant clinical problem. However, indications of red cell damage after heart valve replacement were significantly greater in patients with perivalvular leakage, valve thrombosis, or dysfunction than in those with normally functioning prostheses. Reoperations were necessary because of valve thrombosis (0.46%), perivalvular leakage (2.2

Simultaneous explanation of the RK and R (D (*)) puzzles

Science.gov (United States)

Bhattacharya, Bhubanjyoti; Datta, Alakabha; London, David; Shivashankara, Shanmuka

2015-03-01

At present, there are several hints of lepton flavor non-universality. The LHCb Collaboration has measured RK ≡ B (B+ →K+μ+μ-) / B (B+ →K+e+e-), and the BaBar Collaboration has measured R (D (*)) ≡ B (B bar →D (*) +τ-νbarτ) / B (B bar →D (*) +ℓ-νbarℓ) (ℓ = e , μ). In all cases, the experimental results differ from the standard model predictions by 2- 3 σ. Recently, an explanation of the RK puzzle was proposed in which new physics (NP) generates a neutral-current operator involving only third-generation particles. Now, assuming the scale of NP is much larger than the weak scale, this NP operator must be made invariant under the full SU (3)C × SU (2)L × U(1)Y gauge group. In this Letter, we note that, when this is done, a new charged-current operator can appear, and this can explain the R (D (*)) puzzle. A more precise measurement of the double ratio R (D) / R (D*) can rule out this model.

Türkiye Türkçesinde ve Azerbaycan Türkçesinde “Su” Unsurlu Atasözlerinin Gramer Özellikleri

Directory of Open Access Journals (Sweden)

Ahmet ÖKSÜZ

2014-11-01

Full Text Available Öz İnsanın yaşam tarzı, tarihi, kültürü, hayata bakış açısı dilde yansıtılır. Atalarımızdan bize aktarılan ve anların üzün süre gözlemleyip bir sonuca vararak öğüt ve nasihat şeklinde aktarmış oldukları özlü sözlerdir. Atasözleri değişik dillerde farklı terimlerle telaffuz edilmiştir; Türkçede ise Kaşkarlı Mahmut sav şeklinde ifade ederken daha sonraları Osmanlı Türkçesinde ise darbımesel veya durûb-i emsal kelime grubuyla ifade edilmiştir. Günümüz Türkçesinde ise atasözü şeklinde söylenmektedir. Azerbaycan Türkçesinde ise Atalar sözü terimiyle ifade edilmektedir. Atasözleri toplumda yaşanan olaylardan çıkarılması gereken dersleri bir nasihat bir öğüt şeklinde kısaca anlatır, dile getirir. O nedenle atasözlerini deyimlerden ayıran en önemli tarafı atasözlerinin bir yargı bildirmesidir. Bu öğüt bütün toplumu kapsar ve her zaman doğruya ve iyiye yönlendirir. Diğer taraftan değişik Türk toplulukları kendi atasözlerini toplamışlar ve üzerinde dil çalışmaları yapmışlardır. Bu bakımdan atasözleri ve deyimlerin incelenmesi özel önem taşımaktadır. Türkiye ve Azerbaycan tarihten bu güne hem dilde hem de kültürde birlikteliği sağlamış iki devlettir. Aynı dili konuşmamızın yanında farklı komşuluk ilişkilerine sahip olmamız ve farklı kültürlerden etkilenmemiz nedeni ile hem dilde hem de kültürde azda olsa farklılıklar vardır. Bu farklılıklar atasözlerinde de görülmektedir. Biz bu araştırmamızda iki Türkçede su ile ilgili söylenmiş atasözlerinin gramer özellikleri üzerinde durarak farklı ve benzer yanları nelerdir; bunu ortaya koymaya çalışacağız. Anahtar kelimeler: Atasözleri, Türkiye Türkçesi, Azerbaycan Türkçesi, Türkçe gramer, Türk kültürü, Su kültürü, dil kültürü. The Grammatical Features of the Word “Water” in the Proverbs of Turkey and Azerbaijan Abstract The lifestyle

Türk Çokuluslu İşletmelerinin Stratejik Kadrolama Faaliyetlerinin İncelenmesi

OpenAIRE

Çetinarslan, Haldun Şecaattin; Can, Esin

2018-01-01

Bu araştırmanın amacı Türk Çokulusluİşletmelerinin (ÇUİ) stratejik kadrolama faaliyetlerini incelemektir.Araştırmanın örneklemini, sektörün önde gelen, büyük ve kurumsal 8 Türk ÇUİ’sioluşturmaktadır. Veri toplama yöntemi olarak anket çalışması seçilmiştir. 8Türk ÇUİ’sinin her birinin üst düzey İnsan Kaynakları (İK) yöneticisi (Örneğin;İK’dan sorumlu genel müdür yardımcısı, İK direktörü/başkanı) ile yapılan anketçalışmasından elde edilen veriler analiz edilmiştir. Bulgulara göre; TürkÇUİ’lerin...

Development and identification of a wheat-Roegneria kamoji translocation line T7A/1Rk no.1

International Nuclear Information System (INIS)

Bie Tongde; Feng Yigao; Chen Peidu; Xu Chuanmei

2009-01-01

Pollen of Triticum aestivum-Roegneria kamoji del1Rk No.1L disomic addition line, treated with 10 Gy 6 0C o γ-rays, was pollinated to T · aestivum cv. Chinese Spring. A reciprocal chromosomal translocation line involving wheat 7A and R.kamoji 1Rk No.1 was identified in M 2 generation using the techniques including C-banding, GISH, sequential C-banding/45S rDNA-FISH, and sequential GISH/45S rDNA-FISH. A 45S rDNA locus and its corresponding red band in GISH pattern were observed specific to the short arm of 1Rk No.1 and could be used as a marker of 1Rk No.1 chromosome. Analyses of chromosome constitution of M 2 population and test-crosses showed that the reciprocal translocation chromosomes were co-segregated in offspring, and the transmitting ratios were both higher through female gametes than through male ones. The results of scab resistance identification in 2004, 2005 and 2006 showed that the translocation line conveyed scab resistance that varied in different years in different district. The experiment also showed that pollen irradiation was an effective method to induce wheat-alien chromosome translocations. (authors)

Late complications in patients with Björk-Shiley and St. Jude Medical heart valve replacement.

Science.gov (United States)

Horstkotte, D; Körfer, R; Seipel, L; Bircks, W; Loogen, F

1983-09-01

Valve-related complications after Björk-Shiley mitral valve implantation (n = 475), aortic valve implantation (n = 424), or mitral-aortic valve implantation (n = 119) were compared with those after St. Jude Medical mitral valve replacement (n = 173), aortic valve replacement (n = 152), or mitral-aortic valve replacement (n = 69). All patients were placed on anticoagulant therapy with phenprocoumon early after operation. All patients had a comparable follow-up time of approximately 23 months, which showed that cumulative thromboembolic rates were significantly higher after St. Jude valve implantation than after Björk-Shiley valve implantation. Reoperations were necessary because of valve thrombosis (0.46%), perivalvular leakage (2.2%), or prosthetic valve endocarditis with perivalvular regurgitation (0.46%). One Björk-Shiley mitral valve prosthesis had to be replaced because of fracture of the outlet strut. Without significant intergroup differences, hemorrhage due to anticoagulant treatment was the most frequent complication. Thromboembolic complications were significantly more frequent after Björk-Shiley mitral, aortic, and double valve replacements than after St. Jude valve implantation. This may lead to consideration of changes in the prophylaxis of thrombus formations in the St. Jude valve, especially in aortic valve replacements, in patients with sinus rhythm.

PAN SHARPENING QUALITY INVESTIGATION OF TURKISH IN-OPERATION REMOTE SENSING SATELLITES: APPLICATIONS WITH RASAT AND GÖKTÜRK-2 IMAGES

Directory of Open Access Journals (Sweden)

M. Ozendi

2016-10-01

The aim of this study is to investigate pan-sharpening performance of RASAT and GÖKTÜRK-2 images. For this purpose, pan-sharpened images are generated using most popular pan-sharpening methods IHS, Brovey and PCA at first. This procedure is followed by quantitative evaluation of pan-sharpened images using Correlation Coefficient (CC, Root Mean Square Error (RMSE, Relative Average Spectral Error (RASE, Spectral Angle Mapper (SAM and Erreur Relative Globale Adimensionnelle de Synthése (ERGAS metrics. For generation of pan-sharpened images and computation of metrics SharpQ tool is used which is developed with MATLAB computing language. According to metrics, PCA derived pan-sharpened image is the most similar one to multispectral image for RASAT, and Brovey derived pan-sharpened image is the most similar one to multispectral image for GÖKTÜRK-2. Finally, pan-sharpened images are evaluated qualitatively in terms of object availability and completeness for various land covers (such as urban, forest and flat areas by a group of operators who are experienced in remote sensing imagery.

Verdens vigtigste værk

DEFF Research Database (Denmark)

Ziegler, Magnus Møller

2017-01-01

Karl Marx’ hovedværk, "Kapitalen", fylder i dag præcis 150 år. Selvom det ikke havde stor udbredelse i sin samtid, har værket siden fået status som et af den vestlige idéhistories hovedværker, og Marx’ analyse af kapitalens indre modsætninger er i dag så relevant som nogensinde....

Oligomerisation status and evolutionary conservation of interfaces of protein structural domain superfamilies.

Science.gov (United States)

Sukhwal, Anshul; Sowdhamini, Ramanathan

2013-07-01

Protein-protein interactions are important in carrying out many biological processes and functions. These interactions may be either permanent or of temporary nature. Several studies have employed tools like solvent accessibility and graph theory to identify these interactions, but still more studies need to be performed to quantify and validate them. Although we now have many databases available with predicted and experimental results on protein-protein interactions, we still do not have many databases which focus on providing structural details of the interacting complexes, their oligomerisation state and homologues. In this work, protein-protein interactions have been thoroughly investigated within the structural regime and quantified for their strength using calculated pseudoenergies. The PPCheck server, an in-house webserver, has been used for calculating the pseudoenergies like van der Waals, hydrogen bonds and electrostatic energy based on distances between atoms of amino acids from two interacting proteins. PPCheck can be visited at . Based on statistical data, as obtained by studying established protein-protein interacting complexes from earlier studies, we came to a conclusion that an average protein-protein interface consisted of about 51 to 150 amino acid residues and the generalized energy per residue ranged from -2 kJ mol(-1) to -6 kJ mol(-1). We found that some of the proteins have an exceptionally higher number of amino acids at the interface and it was purely because of their elaborate interface or extended topology i.e. some of their secondary structure regions or loops were either inter-mixing or running parallel to one another or they were taking part in domain swapping. Residue networks were prepared for all the amino acids of the interacting proteins involved in different types of interactions (like van der Waals, hydrogen-bonding, electrostatic or intramolecular interactions) and were analysed between the query domain-interacting partner pair

Environmental Information System Baden-Wuerttemberg. RK UIS 2015 framework concept 2015

International Nuclear Information System (INIS)

Weissenbach, Kurt

2016-01-01

The Baden-Wuerttemberg Environmental Information System (UIS BW), which was set up over 30 years ago, has developed into a strategic national policy instrument for precautionary environmental and climate protection. Its importance will continue to increase as digitalisation progresses. The associated framework concept (RK UIS) has been regularly updated since 1989. The RK UIS 2015 is a fundamental revision of the last framework concept from the year 2006. The legal, technical, technical and organizational requirements that have since been amended have been incorporated and reflected in their impact on the overall conceptual framework. The RK UIS 2015 documents recommendations and development goals for adapting the UIS BW to the changed targets and general conditions. The renewed conceptual framework forms the basis for the further development of the individual UIS components. [de

The Arabidopsis lectin receptor kinase LecRK-V.5 represses stomatal immunity induced by Pseudomonas syringae pv. tomato DC3000.

Directory of Open Access Journals (Sweden)

Marie Desclos-Theveniau

2012-02-01

Full Text Available Stomata play an important role in plant innate immunity by limiting pathogen entry into leaves but molecular mechanisms regulating stomatal closure upon pathogen perception are not well understood. Here we show that the Arabidopsis thaliana L-type lectin receptor kinase-V.5 (LecRK-V.5 negatively regulates stomatal immunity. Loss of LecRK-V.5 function increased resistance to surface inoculation with virulent bacteria Pseudomonas syringae pv tomato DC3000. Levels of resistance were not affected after infiltration-inoculation, suggesting that LecRK-V.5 functions at an early defense stage. By contrast, lines overexpressing LecRK-V.5 were more susceptible to Pst DC3000. Enhanced resistance in lecrk-V.5 mutants was correlated with constitutive stomatal closure, while increased susceptibility phenotypes in overexpression lines were associated with early stomatal reopening. Lines overexpressing LecRK-V.5 also demonstrated a defective stomatal closure after pathogen-associated molecular pattern (PAMP treatments. LecRK-V.5 is rapidly expressed in stomatal guard cells after bacterial inoculation or treatment with the bacterial PAMP flagellin. In addition, lecrk-V.5 mutants guard cells exhibited constitutive accumulation of reactive oxygen species (ROS and inhibition of ROS production opened stomata of lecrk-V.5. LecRK-V.5 is also shown to interfere with abscisic acid-mediated stomatal closure signaling upstream of ROS production. These results provide genetic evidences that LecRK-V.5 negatively regulates stomatal immunity upstream of ROS biosynthesis. Our data reveal that plants have evolved mechanisms to reverse bacteria-mediated stomatal closure to prevent long-term effect on CO(2 uptake and photosynthesis.

Veevärk laiendab haaret / Monika Puutsa

Index Scriptorium Estoniae

Puutsa, Monika

2005-01-01

Kuressaare Veevärk OÜ ja Veemaailm INC sõlmisid lepingu vee- ja kanalisatsioonitorustiku rajamiseks ja uuendamiseks linna 24 tänaval, mis on esimene etapp Saare maakonda hõlmavast Ühtekuuluvusfondi veemajanduse projektist. 80% ulatuses rahastab projekti EL

STOREKEEPER RELATED1/G-Element Binding Protein (STKR1) Interacts with Protein Kinase SnRK11[OPEN

Science.gov (United States)

Nietzsche, Madlen; Guerra, Tiziana; Fernie, Alisdair R.

2018-01-01

Sucrose nonfermenting related kinase1 (SnRK1) is a conserved energy sensor kinase that regulates cellular adaptation to energy deficit in plants. Activation of SnRK1 leads to the down-regulation of ATP-consuming biosynthetic processes and the stimulation of energy-generating catabolic reactions by transcriptional reprogramming and posttranslational modifications. Although considerable progress has been made during the last years in understanding the SnRK1 signaling pathway, many of its components remain unidentified. Here, we show that the catalytic α-subunits KIN10 and KIN11 of the Arabidopsis (Arabidopsis thaliana) SnRK1 complex interact with the STOREKEEPER RELATED1/G-Element Binding Protein (STKR1) inside the plant cell nucleus. Overexpression of STKR1 in transgenic Arabidopsis plants led to reduced growth, a delay in flowering, and strongly attenuated senescence. Metabolite profiling revealed that the transgenic lines exhausted their carbohydrates during the dark period to a greater extent than the wild type and accumulated a range of amino acids. At the global transcriptome level, genes affected by STKR1 overexpression were broadly associated with systemic acquired resistance, and transgenic plants showed enhanced resistance toward a virulent strain of the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis Noco2. We discuss a possible connection of STKR1 function, SnRK1 signaling, and plant immunity. PMID:29192025

Værk og værksted

DEFF Research Database (Denmark)

Kjølsen, Tine; Gammelgaard, Jørgen

2012-01-01

Gerda Thune Andersen – Værk og Værksted Bogen er udgivet i forbindelse med jubilæumsudstillingen på Vendsyssel Kunstmuseum 31 august – 25 november 2012. Udstillingen er blevet til i et samarbejde mellem Vendsyssel Kunstmuseum og Gerda Thune Andersen. Tak til: Jørgen Gammelgaard, Tine Kjølsen, Anne...

Trehalose-6-phosphate and SnRK1 kinases in plant development and signaling: the emerging picture

Directory of Open Access Journals (Sweden)

Sonia eGazzarrini

2014-04-01

Full Text Available Carbohydrates, or sugars, regulate various aspects of plant growth through modulation of cell division and expansion. Besides playing essential roles as sources of energy for growth and as structural components of cells, carbohydrates also regulate the timing of expression of developmental programs. The disaccharide trehalose is used as an energy source, as a storage and transport molecule for glucose, and as a stress-responsive compound important for cellular protection during stress in all kingdoms. Trehalose, however, is found in very low amounts in most plants, pointing to a signaling over metabolic role for this non-reducing disaccharide. In the last decade, trehalose-6-phosphate (T6P, an intermediate in trehalose metabolism, has been shown to regulate embryonic and vegetative development, flowering time, meristem determinacy and cell fate specification in plants. T6P acts as a global regulator of metabolism and transcription promoting plant growth and triggering developmental phase transitions in response to sugar availability. Among the T6P targets are members of the Sucrose-non-fermenting1-Related Kinase1 (SnRK1 family, which are sensors of energy availability and inhibit plant growth and development during metabolic stress to maintain energy homeostasis. In this review, we will discuss the opposite roles of the sugar metabolite T6P and the SnRK1 kinases in the regulation of developmental phase transitions in response to carbohydrate levels. We will focus on how these two global regulators of metabolic processes integrate environmental cues and interact with hormonal signaling pathways to modulate plant development.

Sociale medier og ulovlige netværk i gymnasieskolen

Directory of Open Access Journals (Sweden)

Jesper Tække

2016-03-01

Full Text Available Artiklen handler om spændingen mellem det lærerledede undervisningsfællesskab og kvasi-hemmelige netværk i en gymnasieklasse. Omdrejningspunktet er deling af resultater og opgaver i netværkene gennem hemmelige lukkede Facebook-grupper. Artiklen argumenterer for at denne praksis, hvis ikke den var forbudt, ville komme længere frem i lyset og at lærerne herved ville kunne hjælpe eleverne med trække grænsen mellem snyd, plagiat, inspiration, applikation og appopriation. Hertil ville lærerne kunne hjælpe eleverne med, hvordan man søger og netværker sig til opgaver og trækker på dem i arbejdet med egne opgaver. Til at kvalificere vores analyse og argumentation vil vi primært udgå fra netværksteori. Dette vil navnlig komme til udtryk gennem en løbende diskussion om negativ social arv, der lever videre i netværk og om positiv social arv, der omvendt udraderes i gymnasiets forbudte og derfor hemmelige netværk. Empirisk trækker artiklen på aktionsforskningsprojektet Socio Media Education.

Jänese mälestusmärk

Index Scriptorium Estoniae

2000-01-01

Venemaal Pihkva oblastis Mihhailovskojes on mälestusmärk jänesele, kes takistas 1825. a. Aleksandr Pushkinil Peterburi dekabristide juurde sõitmast ja päästis nii poeedi elu - verstapost, millel on kiri "Senati väljakuni on 416 versta"

rK39 enzyme-linked immunosorbent assay for diagnosis of Leishmania donovani infection

NARCIS (Netherlands)

Zijlstra, E. E.; Daifalla, N. S.; Kager, P. A.; Khalil, E. A.; El-Hassan, A. M.; Reed, S. G.; Ghalib, H. W.

1998-01-01

The rK39 enzyme-linked immunosorbent assay (ELISA) was compared with the direct agglutination test (DAT) for Leishmania donovani infection in the Sudan. rK39 ELISA proved more sensitive than DAT in diagnosis of kala-azar (93 and 80%, respectively); both tests may remain positive up to 24 months

Summary Record of the Fifth Meeting of Records, Knowledge and Memory (RK and M) Across Generations

International Nuclear Information System (INIS)

2013-01-01

Preservation of Records, Knowledge and Memory (RK and M) across Generations is an initiative under the RWMC in the area of knowledge consolidation and transfer. Disposal in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating long-lived radioactive waste from the biosphere. However, there is no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. The cultural dimension of preserving RK and M is an important subject. Overall, long-term preservation of RK and M is a multidisciplinary work area in which much learning is expected over the coming years. This is the task of the RWMC's RK and M initiative. A major outcome will be a menu-driven document that - the RK and M Wiki - that will allow people to identify the elements of a strategic action plan for RK and M preservation. This document is a summary record of the 5. Meeting of the RK and M initiative. The summary is made of 8 items: 1 - Introduction (Claudio Pescatore); 2 - Updates: Wiki Status and Plans (Philippe Maupai, Claudio Pescatore), Glossary (Stephan Hotzel, Claudio Pescatore, Anne Claudel), Bibliography (Anne Claudel, Richard Ferch), Set of Essential Records- SER (Claire Mays); 3 - Documenting Phase I: Master-plan for finalising Phase I (Claudio Pescatore); 4 - Discussion of articles by project participants: The Bibliography and its Analysis (Richard Ferch, Abe Van Luik), Guiding principles (Erik Setzman, Jean-Noel Dumont), Decisions and actions, The connection to safety (Claudio Pescatore, Mareike Rueffer), Archives (Anne Claudel, Sofie Tunbrant), Cultural heritage (Jantine Schroeder, Thomas Kaiserfeld), Causes of loss of Records, Knowledge and Memory (Simon Wisbey, Arne Berckmans); 5 - Regulatory aspects (Richard Ferch, Peter Ormai), Supranational Mechanisms (Jean-Noel Dumont, Anne Claudel), Markers (Jantine Schroeder, Jozsef Fekete), General comments on Strategic Articles

2. Sınıf Türkçe Ders Kitabındaki Metinlerin Okunabilirlik Açısından İncelenmesi

Directory of Open Access Journals (Sweden)

BAYRAM BAŞ

2015-01-01

Full Text Available Ülkemiz, uluslararası platformda okuma becerilerini, okuryazarlığı ve alan becerilerini ölçmeyi hedefleyen PISA, PIRLS (2001 ve TIMSS sınavlarında ortalamanın altında kalmaktadır. Bu durum okuma becerisine sahip olmayan bireyler yetiştirilmesi ile doğru orantılıdır. Okuma okunabilirlik, anlaşılabilirlik ve okunaklık kavramlarını içinde bulunduran bir süreçtir. Okumanın önemli bir ayağı olan okunabilirlikle ilgili çalışmaların geçmişinin çok eskiye dayanmadığı bilinmekle birlikte, eksikliği tartışılmaz bir gerçektir. Türkçenin yapısına uygun hâle getirilmeye çalışılan okunabilirlik formülleri ile çalışmalar yapılsa da istenilen sonuca tam olarak ulaşıldığını söylemek güçtür. Bu çalışma, 2. sınıf Türkçe ders kitabındaki metinlerin okunabilirlik düzeylerini belirlemek amacıyla yapılmıştır. Araştırmada 2014-2015 eğitim-öğretim yılında okutulan Doku Yayınları’na ait 2. Sınıf Türkçe ders kitabındaki öyküleyici ve bilgilendirici metinlerin okunabilirlik düzeyleri ölçülmüş, şiirler kapsam dışında bırakılmıştır. Metinlerin analizinde Ateşman (1997’ın Türkçeye uyarladığı okunabilirlik formülü kullanılmıştır. Araştırma sonucuna göre, öyküleyici metinlerin okunabilirlik puanlarının bilgilendirici metinlerin okunabilirlik puanlarına göre daha yüksek olduğu tespit edilmiştir.

The rK39 strip test is non-predictor of clinical status for kala-azar

Directory of Open Access Journals (Sweden)

Mohapatra Tribhuban M

2009-09-01

Full Text Available Abstract Background The rK39 strip test is reported to be simple, sensitive, specific, non-invasive and economical test. Since this method is supposed to be patient friendly, it may easily be accepted for sero-epidemiological surveys. An attempt was made to evaluate the role of rK39 strip test in pre and post treatment phases of Kala azar, as a diagnostic and prognostic marker, in addition to other laboratory investigations, in order to evaluate its role in sero-epidemiological surveys. Findings A total of 210 cases were selected for the study. One hundred clinically and parasitologically confirmed cases were corroborated with other hematological profiles. The formol-gel test was included along with well matched control group comprising of normal endemic controls (50, non-endemic normals (20 and other febrile cases (40. All groups were tested by rK39 strip test. Fifty Kala azar cases were followed up after completion of successful treatment. They were subjected to rK39 strip test after 0, 90 and 180 days of completion of successful treatment. The rK39 showed sensitivity, specificity, PPV, NPV, and diagnostic accuracy of 98% (95% CI 91.7-100, 100%, 100%, 90% (95% CI 66-100 and 98% (95% CI 92.6-100 respectively. All the 50 cured followed up cases showed positive result by rK39 strip test even after 180 days of completion of successful treatment. Conclusion The test seems an ideal qualitative test for the diagnosis of kala-azar. But for sero-epidemiological studies the test may be used with other parameters. Alternatively a quantitative ELISA using rK39 antigen may be used.

Constitutive modelling of sandvik 1RK91

NARCIS (Netherlands)

Datta, K.; Datta, K.; Hommes, M.; Post, J.; Geijselaers, Hubertus J.M.; Huetink, Han; Beyer, J.; Onate, E; Owen, D.R.J

2003-01-01

A physically based constitutive equation is being developed for the maraging stainless steel Sandvik 1RK91. The steel is used to make precision parts. These parts are formed through multistage forming operations and heat treatments from cold rolled and annealed sheets. The specific alloy is designed

Eesti filmitegijad Moskva foorumi fookuses / Lauri Kärk

Index Scriptorium Estoniae

Kärk, Lauri, 1954-

2004-01-01

24.-30. maini toimus 8. SRÜ ja Baltimaade uue filmi foorum Moskvas, kus Eestist osales kuus filmi. Toimus rida diskussioone. Eestist osalesid Sulev Keedus, Rein Kotov, Lauri Kärk, Elo Tust. Veidi pikemalt ka Kesk-Aasia filmist

Reformatio in peius administratīvo pārkāpumu procesā

OpenAIRE

Berķis, Kaspars

2009-01-01

Maģistra darbā ir pētīta reformatio in peius aizlieguma principa piemērošanas problemātika administratīvo pārkāpumu procesā. Darba gaitā ir analizētas Latvijas Administratīvo pārkāpumu kodeksa, Administratīvā procesa likuma un kriminālprocesuālās tiesību normas, kas satur reformatio in peius aizlieguma principu. Darba ietvaros īpaša uzmanība pievērsta administratīvo tiesu prakses izpētei attiecībā uz reformatio in peius aizlieguma principa piemērošanu administratīvo pārkāpumu lietu izsk...

Digitalisering af det historiske jernbanenetværk

DEFF Research Database (Denmark)

Fertner, Christian

2012-01-01

Centret for Strategisk Byforskning startede i marts 2012 et nyt forskningsprojekt, der omhandler udfordringer hos og fremtiden for danske stationsbyer. Som datagrundlag digitaliserede vi bl.a. det danske jernbane netværk, normal- og smalspor, siden 1847 i grove træk. Denne opgørelse vil vi i det ...

Organization of radioecological research at IAE NNC RK

International Nuclear Information System (INIS)

Azarov, V.A.; Kosatov, V.D.; Sergeev, V.Yu.

1999-01-01

In the report there is a review of basic directions of work conducted at Inst. Atom Energy National Nuclear Center Republic of Kazakhstan (IAE NNC RK) and oriented to solving ecological tasks. Also here an issue on the guarantee system for the quality of the results of the studies valid at the organization. There are results of radiation monitoring at stand complex 'Baikal-1'. Basing on the available scientific-experimental base at IAE NNC RK, there have been proposed ecological research approaches that can involve the organization. To solve ecological tasks the available scientific-technical base helps to perform the following kinds of operations and studies; to determine isotope and element composition of external environment samples; to research radionuclide contamination of terrain (alpha, beta and gamma radiation); to control industrial releases and analysis of heavy metal content in soil, water and air; to find out carcinogenic substance content in food products and other environmental objects; to perform radiation and biological monitoring

Summary Record of the Fourth Meeting of Records, Knowledge and Memory (RK and M) Across Generations Project

International Nuclear Information System (INIS)

2013-01-01

Preservation of Records, Knowledge and Memory (RK and M) across Generations is an initiative under the RWMC in the area of knowledge consolidation and transfer. Disposal in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating long-lived radioactive waste from the biosphere. However, there is no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. The cultural dimension of preserving RK and M is an important subject. Overall, long-term preservation of RK and M is a multidisciplinary work area in which much learning is expected over the coming years. This is the task of the RWMC's RK and M initiative. A major outcome will be a menu-driven document that - the RK and M Wiki - that will allow people to identify the elements of a strategic action plan for RK and M preservation. This document is a summary record of the 4. Meeting of the RK and M project. Three appendices are attached to the summary: - A: Agreed changes to the key observations of the September 2012 Workshop Proceedings; - B: Summary of the discussion and action points regarding the development of the MDD Wiki; - C: Decisions and Actions. The list of participants is also attached to the end of the document. The summary is made of 32 items: 1: Progress Report (Claudio Pescatore); 2: September 2012 Workshop Proceedings (Claudio Pescatore); 3: Glossary and Bibliography Update (Anne Claudel); 4: UNESCO Digital Conference Report and Work with CoData (Claudio Pescatore); 5: Observations on the Proceedings of the UNESCO Digital Memory Conference (Anne Claudel); 6: Discussion; 7: Archives and Digital Libraries (Per Carlsson); 8: Literature Survey on Markers and Memory Preservation (Marcos Buser); 9: Tsunami Stones Report - Development Work (Helen Gordon-Smith); 10: Markers Discussion (Jantine Schroeder); 11: Study of local communities' position on monitoring and the preservation of knowledge

Poolakate kiirmoe kaubamärk püüab rohkem keskmist inimest / Liis Kängsepp

Index Scriptorium Estoniae

Kängsepp, Liis, 1981-

2004-01-01

20-25 aastastele noortele suunatud kiirmoe kontseptsiooni esindavate kaubamärkide Monton ja Reserved konkurentsist Tallinna kaubanduskeskustes. Vt. samas: Reserved murdis kiiresti kasumisse; Montoni Eesti päritolu annab koduturul eelise. Lisad: Kaubamärk Monton; Kaubamärk Reserved. Diagramm: LPP Retail Estonia käive tegi mullu hüppe

Mis on Eesti hariduse eesmärk? / Enn Vatter

Index Scriptorium Estoniae

Vatter, Enn

2003-01-01

Autori arvates ei suudeta valimiseelsetes vaidlustes kokku leppida eelistusis hariduselus. Autor küsib, mis kooli- ja haridustemaatikas peaeesmärk ning mis on alameesmärgid, mis enne peaeesmärgi saavutamist on vaja kätte saada

Åben innovation i virksomhedsnetværk: Et spørgsmål om lederskab?

DEFF Research Database (Denmark)

Goduscheit, René Chester

2007-01-01

form af eksempelvis virksomhedsnetværk, er således stigende. Det viser sig bare, at det ikke er nok at ringe til nogle relevante virksomheder og bede dem om at komme og 'hjælpe dem med at lave noget innovation'. Alt for mange netværk lider en hurtig død - ressourcerne i de enkelte virksomheder og...... synergien mellem dem realiseres kun i meget begrænset omfang. Netværksmøderne bliver blot hyggelige sammenrend uden et konkret udbytte i form af nye produkter, services etc. Artiklen beskriver, hvordan virksomheder, som ønsker at skabe og udvikle et virk-somhedsnetværk omkring innovation, kan lede netværket...

SABIO-RK: A data warehouse for biochemical reactions and their kinetics

Directory of Open Access Journals (Sweden)

Krebs Olga

2007-03-01

Full Text Available Systems biology is an emerging field that aims at obtaining a system-level understanding of biological processes. The modelling and simulation of networks of biochemical reactions have great and promising application potential but require reliable kinetic data. In order to support the systems biology community with such data we have developed SABIO-RK (System for the Analysis of Biochemical Pathways - Reaction Kinetics, a curated database with information about biochemical reactions and their kinetic properties, which allows researchers to obtain and compare kinetic data and to integrate them into models of biochemical networks. SABIO-RK is freely available for academic use at http://sabio.villa-bosch.de/SABIORK/.

Björk aitab põhjamaades õppida / Epp Adler

Index Scriptorium Estoniae

Adler, Epp

2008-01-01

Põhjamaade Ministrite Nõukogu ja põhjamaade saatkondade koostöös on teoks saanud laiahaardeline ja mitmekülgne hariduse ja karjäärivalikute teavitusprogramm "Björk - õpi Põhjamaades". Teavitusprogrammi fookuses on kutseõpe, e-õpe ja elukestev õpe

Mörk turism - en undersökning om underliggande motiv till unga vuxnas intresse för fenomenet

OpenAIRE

Lindroos, Julia

2017-01-01

Mörk turism är ett begrepp som inte väldigt många känner till även om det är ganska populärt som turist att besöka någon form av mörk turism. Syftet med detta arbete är redogöra för vilka motiven bakom unga vuxnas intresse för mörk turism är och vilka känslor som kan uppstå vid besöken av en mörk turism plats. Målgruppen för detta arbete är unga vuxna i åldren 18-29 år från södra Svenskfinland. Den teoretiska referensramen består av motivationsfaktorer, konsumentbeteende samt destinationsteor...

Uudised : Tõnso. Triibud. Björk. DVD

Index Scriptorium Estoniae

2005-01-01

Juuli lõpus ja augusti alguses Leigo järvel etenduvale Shakespeare'i näidendile "Suveöö muusika" kirjutab originaalmuusika Aivar Tõnso. Detroidi duot White Stripes soojendab Tallinna kontserdil 29. juunil klubis Hollywood ansambel Röövel Ööbik. Islandi lauljatar Björk annab juulis välja soundtrack-plaadi Matthew Barney viimasele filmile "Drawing Restraint 9". Piraat-DVDde arestimisest Suurbritannias

Niğde Türk Ocağı’nın Kuruluşu ve İlk Faaliyetleri (1924-1926 The Establishment And First Activities Of Niğde Türk Ocağı (1924-1926

Directory of Open Access Journals (Sweden)

Nevzat TOPAL

2013-09-01

Full Text Available “Türk Ocakları” which had been established in 1911 was re-organized after national conflict. “Niğde Türk Ocağı” was one of the establishments organized after national conflict. We evaluated the establisments and first activities of “Ocak” from the news of some newspapers we could obtain which had been published in Niğde. It was impossible to find a full collection of Niğde newspapers in libraries and archives. So, no researches were made about the activities and establishment of “Niğde Türk Ocağı”. It was possible to mark the activities and establishment of “Ocak” from the newspapers and documents that we could obtain by Mehmet Yılmaz Savaşçın who was the son of selected chairman of “Niğde Türk Ocağı” in 1925 Hasan Hüsnü (Savaşçın.According to documents and newspapers we had, “Niğde Türk Ocağı” was established at September 1924. First chairman of administrative board was C. Şehabeddin (Tüzün. There is a misbelief about this person for he can be the famous poet C. Şehabeddin. But in this study it was discovered that Şehabeddin had worked as lawyer in Niğde. The administrative board changed at the congress in January 9 1925 after Şehabettin Bey’s short (about six months regimen. Hasan Hüsnü (Savaşçın was selected as the chairman of second administrative board. According to identity certificate which was only for members of “Türk Ocakları” the first numbered member was Hüsnü Bey. Hüsnü Bey had organized and functionalized the “Ocak” in a short time. “Niğde Türk Ocağı” supported to cultural life of Niğde with its activities. The establishment and first activities of “Niğde Türk Ocağı” was evaluated for the first time by our limited documents. Fiili olarak 1911 senesinde kurulan Türk Ocakları Milli Mücadele sonrasında yeniden teşkilatlanmaya gitmiştir. Niğde Türk Ocağı Milli Mücadele sonrası kurulan teşkilatlardan birisidir. Oca

Türkçede Ön Seste Y Initial Phonem Y In Turkish

Directory of Open Access Journals (Sweden)

Sertan ALİBEKİROĞLU

2013-03-01

Full Text Available The Turkish language, which has an ancient history, is spread to a wide geography in the old continents. In classification of Turkish, Turcologists use different measures because this spread and natural qualifier of languages which is being alive are the main reasons that Turkish to branch into many dialects and accents. Studies ofTurcologists who use dialect for the classification of Turkish show thatthere are equivalences between West and East branches of theFirst/Proto Turkish on “l-ş”, “r-z” in internal and final phoneme; andon y-s/ş in initial phonemes. Between the Ancient and ModernTurkish, there emerged-especially base on time and place-manyphoneme evaluations and formed phoneme equivalences betweendialects. These equivalences allow us to understand current situationof the language and have information for the future while they shedlight evaluation of Turkish in its long historical journey. This studyaims to show the changes of the initial phoneme y which is used inclassification based on dialects. These changes will be shown byfirstly, determining if during the First Turkish, there were theconsonant primarily “y-” in initial phonemes of words, anddetermining the position of “y-” before the written era of Turkish; andsecondly, presenting the positions of initial phoneme y- during thewritten era of Turkish. Following these motivations, the study onlyconsiders the initial phoneme “y-” and does not include the changes ininternal and final phonemes. Kökleri çok eski tarihlere uzanan Türkçe, eski kıtalar üzerinde çok geniş coğrafyalara yayılmıştır. Bu coğrafyalara yayılım ve dilin doğasında bulunan canlı bir varlık olma vasfının Türkçenin çok çeşitli lehçe ve şivelere ayrılarak dallanmasının ana sebeplerini oluşturması, Türkologların, Türkçeyi tasnif ederken değişik ölçüler kullanmalarına neden olmuştur. Coğrafya, boy adları ve lehçe özelliklerine göre tasnif edilmeye �

Tangible and Intangible Values of Atatürk Forest Farm as a Heritage of Ideas

Directory of Open Access Journals (Sweden)

Selin Çavdar Sert

2017-12-01

Full Text Available Within the shared boundaries of various disciplinary domains, there are a substantial number of studies dealing with the history of the establishment and socio-spatial values of Atatürk Forest Farm. The area is represented through the semantic field related to the venerable memory of Mustafa Kemal Atatürk and his heritage of ideas; the social, cultural and spatial goals of the republican revolution; the principles and procedures of being a modern and self-sufficient society; and the history of the establishment of Ankara as a capital. The Atatürk Forest Farm also comprises tangible cultural assets and natural systems – which transcend the borders of the site. Yet, there has not been any study identifying and associating the tangible and intangible values of the farm in a comprehensive way. This study aims to draw a layout for interdisciplinary conservation scenarios that would place the tangible and intangible assets of Atatürk Forest Farm – whose universalisation has been noticeably postponed – and the heritage of ideas bequeathed to future generations in the form of the forest and farm

Evaluation of Atatürk' s Leadership Styles on The Base Of Autocratic And Democratic Leadership Behaviors

OpenAIRE

ARIKAN, Semra

2001-01-01

 The mainpurpose of this study is to explain the concepts of leader and leadership andthen analyze the leadership styles of Mustafa Kemal Atatürk. Conclusively, itwas found out that Atatürk was a leader,who displayed both autocratic anddemocratic leadership behaviors whereby his democratic leadership attitudeswere distinctively predominating. 

Two-component system VicRK regulates functions associated with establishment of Streptococcus sanguinis in biofilms.

Science.gov (United States)

Moraes, Julianna J; Stipp, Rafael N; Harth-Chu, Erika N; Camargo, Tarsila M; Höfling, José F; Mattos-Graner, Renata O

2014-12-01

Streptococcus sanguinis is a commensal pioneer colonizer of teeth and an opportunistic pathogen of infectious endocarditis. The establishment of S. sanguinis in host sites likely requires dynamic fitting of the cell wall in response to local stimuli. In this study, we investigated the two-component system (TCS) VicRK in S. sanguinis (VicRKSs), which regulates genes of cell wall biogenesis, biofilm formation, and virulence in opportunistic pathogens. A vicK knockout mutant obtained from strain SK36 (SKvic) showed slight reductions in aerobic growth and resistance to oxidative stress but an impaired ability to form biofilms, a phenotype restored in the complemented mutant. The biofilm-defective phenotype was associated with reduced amounts of extracellular DNA during aerobic growth, with reduced production of H2O2, a metabolic product associated with DNA release, and with inhibitory capacity of S. sanguinis competitor species. No changes in autolysis or cell surface hydrophobicity were detected in SKvic. Reverse transcription-quantitative PCR (RT-qPCR), electrophoretic mobility shift assays (EMSA), and promoter sequence analyses revealed that VicR directly regulates genes encoding murein hydrolases (SSA_0094, cwdP, and gbpB) and spxB, which encodes pyruvate oxidase for H2O2 production. Genes previously associated with spxB expression (spxR, ccpA, ackA, and tpK) were not transcriptionally affected in SKvic. RT-qPCR analyses of S. sanguinis biofilm cells further showed upregulation of VicRK targets (spxB, gbpB, and SSA_0094) and other genes for biofilm formation (gtfP and comE) compared to expression in planktonic cells. This study provides evidence that VicRKSs regulates functions crucial for S. sanguinis establishment in biofilms and identifies novel VicRK targets potentially involved in hydrolytic activities of the cell wall required for these functions. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Preliminary plant design of Escherichia coli BPPTCC-EgRK2 cell culture for recombinant cellulase production using Oil Palm Empty Fruit Bunch (OPEFB) as substrate

Science.gov (United States)

Surya, E. A.; Rahman, S. F.; Zulamraini, S.; Gozan, M.

2018-03-01

An economic analysis of recombinant cellulase production from E. coli BPPTCC Eg-RK2 was conducted to support the fulfilling of Indonesia’s energy roadmap for ethanol production. The plant use oil palm empty fruit bunch (OPEFB) as primary substrate in cellulase production, with the expected lifetime of 12 years. The plant is assumed to be built in Indonesia and will fulfill 1% of total market demand. The effect of different pretreatment process (alkaline, steam explosion, and sequential acid-alkaline) on the economic value was also studied. A simulation using SuperPro Designer was used to calculate the mass and energy balance based on the kinetic parameter of E. coli BPPTCC-EgRK2. Technology evaluation show that alkaline pretreatment gave the highest yield with no known inhibitors formed. The steam explosion show the lowest lignin and hemicellulose removal and known to form known fermentation inhibitors. The net present value of alkaline, steam explosion, and sequential acid-alkaline pretreatment were USD 7,118,000; - USD 73,411,000 and USD -114,013,000 respectively, which mean alkaline pretreatment is the only economically feasible pretreatment method for recombinant cellulase production.

Glossary of Terms. Preservation of Records, Knowledge and Memory (RK and M) Across Generations. Draft - Definitions as of 3 March 2014

International Nuclear Information System (INIS)

2014-01-01

The RK and M glossary defines important concepts and terms that are commonly used. It is under continuous development by the project team and represents a peer-reviewed set of terms. It should be pointed out that some terms may be defined differently from other glossaries in science and technology. The RK and M glossary, however, fits the purpose of achieving a better understanding and more efficient communication of RK and M issues. The aim of the RK and M glossary is to compile a dedicated, internally consistent, and unambiguous set of definitions. Each definition should not be seen in isolation, but as complementary to the definition of other terms in the glossary

Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases

Science.gov (United States)

Crozet, Pierre; Margalha, Leonor; Confraria, Ana; Rodrigues, Américo; Martinho, Cláudia; Adamo, Mattia; Elias, Carlos A.; Baena-González, Elena

2014-01-01

The SNF1 (sucrose non-fermenting 1)-related protein kinases 1 (SnRKs1) are the plant orthologs of the budding yeast SNF1 and mammalian AMPK (AMP-activated protein kinase). These evolutionarily conserved kinases are metabolic sensors that undergo activation in response to declining energy levels. Upon activation, SNF1/AMPK/SnRK1 kinases trigger a vast transcriptional and metabolic reprograming that restores energy homeostasis and promotes tolerance to adverse conditions, partly through an induction of catabolic processes and a general repression of anabolism. These kinases typically function as a heterotrimeric complex composed of two regulatory subunits, β and γ, and an α-catalytic subunit, which requires phosphorylation of a conserved activation loop residue for activity. Additionally, SNF1/AMPK/SnRK1 kinases are controlled by multiple mechanisms that have an impact on kinase activity, stability, and/or subcellular localization. Here we will review current knowledge on the regulation of SNF1/AMPK/SnRK1 by upstream components, post-translational modifications, various metabolites, hormones, and others, in an attempt to highlight both the commonalities of these essential eukaryotic kinases and the divergences that have evolved to cope with the particularities of each one of these systems. PMID:24904600

Nervous Cowboys ja Eesti kui märk Prahas

Index Scriptorium Estoniae

1999-01-01

16. XI toimus Tšehhi pealinna Praha Karli sillal Eesti Taassünnipäevale pühendatud performance 'Eesti kui märk', mille viis läbi kunstirühmitus Nervous Cowboys koosseisus Kiwa ja Jasper Zoova. Eesti Suursaatkonnas avati näitus, kus eksponeeritakse xerox-tehnikas graafilisi lehti ja performance'i videdokumentatsiooni.

The Björk-Shiley 70 degree convexo-concave prosthesis strut fracture problem (present state of information).

Science.gov (United States)

Ostermeyer, J; Horstkotte, D; Bennett, J; Huysmans, H; Lindblom, D; Olin, C; Orinius, E; Semb, G

1987-04-01

Between June 1980 and June 1983 4028 Björk-Shiley 70 degree convexo-concave prosthetic heart valves were distributed and implanted in Australia, Canada, Europe and South Africa. As of March 1986, a total of 52 outlet strut fractures (1.29%; 70% CL: 1.1%-1.5%) have been reported from 29 implant institutions in 12 countries. The majority (82.7%) occurred in Europe. Intervals between implantation and fracture were 13 days to 45.3 months (mean: 18.4 months; 70% CL: 16.6 months-20.1 months). The mortality rate after strut fracture was 78.7% (70% CL: 72.5%-84.9%). Upon stratification of the fracture by valve sizes and types it becomes evident that 75% (70% CL: 68.8%-81.2%) of all fractures are related to the sizes 29 mm to 33 mm (which virtually represent the same valve size) and predominantly to mitral valves (p less than 0.01). The large valves again have been stratified into two subsets, namely those fabricated from flanges originally machined as Björk-Shiley 60 degree convexo-concave valves (group I) and later produced valves machined initially to 70 degree specifications (group II). In group I the fracture rate was 5.2% (70% CL: 4.2%-6.2%) versus 1.6% (70% CL: 1.1%-2.1%) in group II (p less than 0.01), which identifies the group I 29 mm-33 mm Björk-Shiley 70 degree convexo-concave valves as the highest risk group for strut fracture. The rates are based upon all available information as of March 16, 1986.(ABSTRACT TRUNCATED AT 250 WORDS)

Biological control of strawberry Fusarium wilt caused by Fusarium oxysporum f. sp. fragariae using Bacillus velezensis BS87 and RK1 formulation.

Science.gov (United States)

Nam, Myeong Hyeon; Park, Myung Soo; Kim, Hong Gi; Yoo, Sung Joon

2009-05-01

Two isolates, Bacillus sp. BS87 and RK1, selected from soil in strawberry fields in Korea, showed high levels of antagonism towards Fusarium oxysporum f. sp. fragariae in vitro. The isolates were identified as B. velezensis based on the homology of their gyrA sequences to reference strains. BS87 and RK1 were evaluated for control of Fusarium wilt in strawberries in pot trials and field trials conducted in Nonsan, Korea. In the pot trials, the optimum applied concentration of BS87 and RK1 for pre-plant root-dip application to control Fusarium wilt was 10(5) and 10(6) colony-forming units (CFU)/ml, respectively. Meanwhile, in the 2003 and 2005 field trials, the biological control efficacies of formulations of RK1 were similar to that of a conventional fungicide (copper hydroxide) when compared with a non-treated control. The RK1 formulation was also more effective than BS87 in suppressing Fusarium wilt under field conditions. Therefore, the results indicated that formulation of B.velezensis BS87 and RK1 may have potential to control Fusarium wilt in strawberries.

Cucumis sativus L-type lectin receptor kinase (CsLecRK) gene family response to Phytophthora melonis, Phytophthora capsici and water immersion in disease resistant and susceptible cucumber cultivars.

Science.gov (United States)

Wu, Tingquan; Wang, Rui; Xu, Xiaomei; He, Xiaoming; Sun, Baojuan; Zhong, Yujuan; Liang, Zhaojuan; Luo, Shaobo; Lin, Yu'e

2014-10-10

L-type lectin receptor kinase (LecRK) proteins are an important family involved in diverse biological processes such as pollen development, senescence, wounding, salinity and especially in innate immunity in model plants such as Arabidopsis and tobacco. Till date, LecRK proteins or genes of cucumber have not been reported. In this study, a total of 25 LecRK genes were identified in the cucumber genome, unequally distributed across its seven chromosomes. According to similarity comparison of their encoded proteins, the Cucumis sativus LecRK (CsLecRK) genes were classified into six major clades (from Clade I to CladeVI). Expression of CsLecRK genes were tested using QRT-PCR method and the results showed that 25 CsLecRK genes exhibited different responses to abiotic (water immersion) and biotic (Phytophthora melonis and Phytophthora capsici inoculation) stresses, as well as that between disease resistant cultivar (JSH) and disease susceptible cultivar (B80). Among the 25 CsLecRK genes, we found CsLecRK6.1 was especially induced by P. melonis and P. capsici in JSH plants. All these results suggested that CsLecRK genes may play important roles in biotic and abiotic stresses. Copyright © 2014 Elsevier B.V. All rights reserved.

Characterization of a Potential Probiotic Lactobacillus brevis RK03 and Efficient Production of γ-Aminobutyric Acid in Batch Fermentation

Directory of Open Access Journals (Sweden)

Chien-Hui Wu

2018-01-01

Full Text Available Lactic acid bacteria were isolated from fish and evaluated for their γ-aminobutyric acid (GABA-producing abilities. Out of thirty-two isolates, Lactobacillus brevis RK03 showed the highest GABA production ability. The effects of various fermentation parameters including initial glutamic acid level, culture temperature, initial pH, and incubation time on GABA production were investigated via a singleparameter optimization strategy. For industrial large-scale production, a low-cost GABA producing medium (GM broth was developed for fermentation with L. brevis RK03. We found that an optimized GM broth recipe of 1% glucose; 2.5% yeast extract; 2 ppm each of CaCO3, MnSO4, and Tween 80; and 10 μM pyridoxal phosphate (PLP resulted in a maximum GABA yield of 62,523 mg/L after 88 h following the addition of 650 mM monosodium glutamate (MSG, for a conversion rate of 93.28%. Our data provide a practical approach for the highly efficient and economic production of GABA. In addition, L. brevis RK03 is highly resistant to gastric acid and bovine bile salt. Thus, the discovery of Lactobacillus strains with the ability to synthesize GABA may offer new opportunities in the design of improved health-promoting functional foods.

Characterization of a Potential Probiotic Lactobacillus brevis RK03 and Efficient Production of γ-Aminobutyric Acid in Batch Fermentation.

Science.gov (United States)

Wu, Chien-Hui; Hsueh, Yi-Huang; Kuo, Jen-Min; Liu, Si-Jia

2018-01-04

Lactic acid bacteria were isolated from fish and evaluated for their γ-aminobutyric acid (GABA)-producing abilities. Out of thirty-two isolates, Lactobacillus brevis RK03 showed the highest GABA production ability. The effects of various fermentation parameters including initial glutamic acid level, culture temperature, initial pH, and incubation time on GABA production were investigated via a singleparameter optimization strategy. For industrial large-scale production, a low-cost GABA producing medium (GM) broth was developed for fermentation with L. brevis RK03. We found that an optimized GM broth recipe of 1% glucose; 2.5% yeast extract; 2 ppm each of CaCO₃, MnSO₄, and Tween 80; and 10 μM pyridoxal phosphate (PLP) resulted in a maximum GABA yield of 62,523 mg/L after 88 h following the addition of 650 mM monosodium glutamate (MSG), for a conversion rate of 93.28%. Our data provide a practical approach for the highly efficient and economic production of GABA. In addition, L. brevis RK03 is highly resistant to gastric acid and bovine bile salt. Thus, the discovery of Lactobacillus strains with the ability to synthesize GABA may offer new opportunities in the design of improved health-promoting functional foods.

"Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

Index Scriptorium Estoniae

2006-01-01

Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest. Ka teistest festivalil auhinnasaajatest

Björk-Shiley strut fracture and disc escape: literature review and a method of disc retrieval.

Science.gov (United States)

Hendel, P N

1989-03-01

Embolization of a prosthetic valve poppet is a rare but life-threatening event. It was reported sporadically before the introduction of the Björk-Shiley 70-degree convexoconcave prosthesis in 1980. Since that time, there have been a large number of reported mechanical failures with disc escape. The rate for the 29-mm to 33-mm mitral valves is estimated as 5.2%. In 29 of 35 patients (including the 2 presented here) in whom the site of disc lodgment could be determined, the disc was in the descending or abdominal aorta. Fifteen of these patients died. Six survivors had the disc removed at the same operation and 6 at a later operation. In 2 patients, the disc was not removed. In 2 patients in whom the disc was not removed initially, it was thought to contribute to postoperative complications. Two more cases of structural failure of the Björk-Shiley convexoconcave prosthesis are presented. A transpericardial approach to the descending aorta on bypass is described. It allows easy removal of the disc and eliminates the need for a second operation.

Emsâl ü Nesâyih-i Türkî ve Dil Özellikleri Üzerine The Emsâl ü Nesâyih-i Türkî and Its Language Properties

Directory of Open Access Journals (Sweden)

Talip DOĞAN

2013-09-01

Full Text Available The proverbs that reflect the characters of nations, their manner and mentality against life are connected to lots of fields such as language, literature, history, folklore, sociology, psychology and philosophy. Also these sayings are very important language characteristics in terms of strong expression and conceptual richness.When said in the right time, these sayings give power to the thoughtand we can see that they are made use of all the opportunity oflanguage. The proverbs which are one of the products of oral culturesetting have the power of expressing every kind of events about life withevery aspect and colorfulness. So we can see the religious, moral,understanding, common values, mental state, imagination andintelligence glitters of Turkish nation. Turkish proverbs show thecharacter of Turk beyond the differences like geography and dialect andalso they have the characteristics of a historical document. Proverb inTurkish language was called as the words like sav, mesel anddarbımesel. Today, Azerbaijan Turks use the terms like atalar sözü, atababa sözleri, emsâl, emsâl-i Türkân instead of proverb.Emåāl ü Neṣāyiḥ-i Türkì was written by Mìrzā ‘Elineḳì Merāġì inMeraga city of Iran Azerbaijan in the early years of 20th century. Thehandwritten literal work has Talîk-Divanî font style. Emåāl ü Neṣāyiḥ-iTürkì is thirty three pages and includes proverbs. Proverbs were savedaccording to letters lined up of Arab Alphabet and their dialectcharacteristics were saved.In this study, spelling, voice and form properties of proverbs inThe Emåāl ü Neṣāyiḥ-i Türkì have been examined. In addition to this,language properties have been compared with historical dialects anddialects of Oguz group. Milletlerin karakterlerini, hayat karşısındaki tutum ve zihniyetlerini yansıtan atasözleri; dil, edebiyat, tarih, folklor, sosyoloji, psikoloji, felsefe gibi çeşitli alanlarla yakından ilgilidir. Bu sözler ayr

Innovation projects of atomic energy institute of national nuclear center RK in the area of peaceful use of atomic energy

International Nuclear Information System (INIS)

Kenzhin, E.; Tazhibayeva, I.; Vasiliyev, Y.; Kolodeshnikov, A.; Vurim, A.

2010-01-01

Institute of Atomic Energy of National Nuclear Center RK (IAE NNC RK) is located in Kurchatov. The city is situated at the border of former Semipalatinsk test site. The institute includes two reactor complexes - IGR and Baikal-1, which are rather distant from Kurchatov. Main activities of IAE NNC RK are: 1. Experimental researches of the nuclear power reactors safety; 2. Experimental researches of behavior of the structural materials for fusion and fission facilities under reactor irradiation; 3. Management of radioactive wastes; 4. Participation in the projects on decommissioning of the fast neutron reactor BN-350; 5. innovation projects: creation of first Kazakhstan's fusion reactor - tokamak KTM for materials; research and testing; development of new technologies (irradiated Be-recycling); development of new reactor technologies - project on creation of high temperature gas-cooled reactor KHTR. IAE NNC RK jointly with Japanese Atomic Energy Agency and with participation of Japanese Atomic Power Company is performing the activities on experimental substantiation of design of active core of prospective fast neutron reactor. Main goal of out-of-pile experiments at the EAGLE facility is obtaining of the information on fuel movement processes under conditions simulating the accident with melting of fast reactor core containing tube-design fuel assembly. Batch mixture is loaded into graphite crucible; then it is melded into electric melting furnace and poured into melt top trap. The outlet pipe is melted by the melt, which is poured into bottom melt trap through the pipe with sodium

The two-component system VicRK regulates functions associated with Streptococcus mutans resistance to complement immunity.

Science.gov (United States)

Alves, Livia A; Harth-Chu, Erika N; Palma, Thais H; Stipp, Rafael N; Mariano, Flávia S; Höfling, José F; Abranches, Jacqueline; Mattos-Graner, Renata O

2017-10-01

Streptococcus mutans, a dental caries pathogen, can promote systemic infections upon reaching the bloodstream. The two-component system (TCS) VicRK Sm of S. mutans regulates the synthesis of and interaction with sucrose-derived exopolysaccharides (EPS), processes associated with oral and systemic virulence. In this study, we investigated the mechanisms by which VicRK Sm affects S. mutans susceptibility to blood-mediated immunity. Compared with parent strain UA159, the vicK Sm isogenic mutant (UAvic) showed reduced susceptibility to deposition of C3b of complement, low binding to serum immunoglobulin G (IgG), and low frequency of C3b/IgG-mediated opsonophagocytosis by polymorphonuclear cells in a sucrose-independent way (Pmutans employs mechanisms of complement evasion through peptidases, which are controlled by VicRK Sm. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Dilbilim Kavramları Işığında Türkçe Öğretimi

Directory of Open Access Journals (Sweden)

Nilay Çağlayan DİLBER

2017-12-01

Full Text Available Anadili olarak Türkçe öğretiminde hem öğretmen yetiştirme hem de ilköğretim öğrencisi yetiştirme anlamında dilbilime ve dilbilimin elde ettiği verilere yeterince önem verilmemektedir. Oysa gelişmiş ülkelerdeki anadili eğitimine bakıldığında dilbilimden ve verilerinden sıkça yararlanılmaktadır. Yapılan çalışmada da bu eksikliği gidermek adına dilbilim kuramlarında yer alan kavramların anadili olarak Türkçe öğretiminde somut olarak nasıl yer alabileceğini ve zaten yer aldığını göstermek amaçlanmaktadır. Bu doğrultuda F. De Saussure ile bir bilim haline gelen ve 19. yy. itibariyle kuramlar üzerine yeni kuramlar üreterek dili farklı açılardan betimleyen Genel Dilbilim ders notları, Avrupa Yapısalcılığı, Amerikan Yapısalcılığı, Üretici Dönüşümsel Dilbilgisi, Edimbilim ve Sözceleme Kuramları’nda kullanılan ve bu kuramlarla ortaya çıkan bazı kavramların Türkçe öğretiminde kullanımı somut bir şekilde örneklendirilerek verilmiştir. Bu örneklerin Türkçe ders kitaplarına, etkinliklere, öğretim materyallerine yardımcı olacağı öngörülmektedir. Ayrıca çalışmanın Türkçe öğretmen adaylarının dilbilime daha somut bir şekilde yaklaşmasına ve dilbilimin dil öğretimindeki gerekliliğini anlamalarına yardımcı olacağı düşünülmektedir.

Yabancı turistlerin Türk mutfağından beklentileri, yararlanma durumları ve Türk mutfağının turizme katkısı üzerine bir araştırma

OpenAIRE

AKMAN, Mehmet

1998-01-01

      Bu araştırma, ülkemize gelen ve tatil köylerinde konaklayan yaban cı turistlerin Türk mutfağını tanıma düzeylerini Türk mutfağı ve yemeklerine ilişkin düşünceleri ile ülkemizdeki turistik tatil köylerinde verilen yiyecek-içecek hizmetler...

[Minor strut fracture of the Björk-Shiley mitral valve].

Science.gov (United States)

Sugita, T; Yasuda, R; Watarida, S; Onoe, M; Tabata, R; Mori, A

1990-06-01

In May, 1982, a 49-year-old man underwent mitral valve replacement (MVR) in our hospital with a 31 mm Björk-Shiley prosthesis for mitral regurgitation. He had been doing well until his episode of palpitation and dyspnea of sudden onset, and was transferred to our ICU with severe cardiogenic shock in Aug, 1986. Chest X-ray film revealed pulmonary edema and breakage of the valve with migration of the disc and the minor strut of the prosthesis. He was operated upon 5 hours after the onset of his complaints. The minor strut was removed from the left upper pulmonary vein and mitral valve re-replacement was done with a 29 mm Björk-Shiley Monostrut valve. The disc which had dislocated into the abdominal aorta was also recovered on the twenty-third post operative day. His postoperative course was uneventful. Immediate diagnosis and subsequent re-operation is absolute indication for rescue from acute cardiac failure due to mechanical failure of any prosthetic valve.

IMPACT OF THE ATATÜRK DAM LAKE ON AGRO-METEOROLOGICAL ASPECTS OF THE SOUTHEASTERN ANATOLIA REGION USING REMOTE SENSING AND GIS ANALYSIS

Directory of Open Access Journals (Sweden)

O. Ozcan

2012-07-01

Full Text Available The Atatürk Dam is the fourth largest clay-cored rock fill dam in the world. It was constructed on the Euphrates River located in semi-arid Southeastern Turkey in the 1980s as the central component of a large-scale regional development project for the Southeastern Anatolia region (referred to as GAP. The construction began in 1983 and was completed in 1990. The dam and the hydroelectric power plant, which went into service after filling up the reservoir was accomplished in 1992. The Atatürk Dam, which has a height of 169 m, a total storage capacity of 48.7 million m3, and a surface area of about 817 km2 plays an important role in the development of Turkey's energy and agriculture sectors. In this study, the spatial and temporal impacts of the Atatürk Dam on agro-meteorological aspects of the Southeastern Anatolia region have been investigated. Change detection and environmental impacts due to water-reserve changes in Atatürk Dam Lake have been determined and evaluated using multi-temporal Landsat satellite imageries and meteorological datasets within a period of 1984 to 2011. These time series have been evaluated for three time periods. Dam construction period constitutes the first part of the study. Land cover/use changes especially on agricultural fields under the Atatürk Dam Lake and its vicinity have been identified between the periods of 1984 to 1992. The second period comprises the 10-year period after the completion of filling up the reservoir in 1992. At this period, Landsat and meteorological time-series analyses are examined to assess the impact of the Atatürk Dam Lake on selected irrigated agricultural areas. For the last 9-year period from 2002 to 2011, the relationships between seasonal water-reserve changes and irrigated plains under changing climatic factors primarily driving vegetation activity (monthly, seasonal, and annual fluctuations of rainfall rate, air temperature, humidity on the watershed have been investigated

SOME RELATED FACTORS AND SITUATION OF BODY WEIGHT IN ATATÜRK UNIVERSITY STUDENTS

Directory of Open Access Journals (Sweden)

Serhat VANÇELİK

2006-03-01

Full Text Available This study was carried out to evaluate the weight situations of the students of Atatürk University, and to reveal the factors which might influence body of weight. The study was carried out between May and June 2004. The population of the study consisted of seventeen thousands students attending their formal education in Atatürk University Campus. It was determined that the number of the students including in the study was 1250, but the participation rate in the study was 89.6% (1120 person. With simple randomized method, which classroom of each faculty would be included in the sampling was determined. All the students in determined classroom were included in the study content. Percent of the male students were 60.6 % and single students were 96.6% . Mean age of students were 21.6 ± 1.9 year, average body mass index (BMI value was 21.9 ± 2.7 kg/m2. The prevalence of overweight and obesity were higher in the male students, and the thinness were higher in female students. It was found out that there was no statistically significant distinction in terms of BMI values averages according to their making regular sport, using alcohol and smoking and taking nutrition education. There was significant correlation between BMI score and monthly personal income.

TÜRK TOPLUMUNDA BAHŞİŞ

OpenAIRE

Akpınar, Aylin

2010-01-01

Bu makalede bahşiş verme adeti, sembolik bir güç ve ritüel olarak Osmanlı-Türk toplumunda gündelikhayat pratikleri ve hediye verme gelenekleri içerisindeki rolü çerçevesinde incelenmektedir. Osmanlıtoplumunda ondokuzuncu yüzyıla doğru giderek artan sosyal farklılıklar, sosyal yardımlaşma yerine bahşişverme adetini getirmiştir. Bayramlarda çocuklara ve yoksullara, ramazanlarda davulcu ve bekçilere verilenbahşişler ile düğünlerde damat ve gelin ailelerinin dağıttığı bahşişler, manevi cömertlik ...

The Arabidopsis thaliana lectin receptor kinase LecRK-I.9 is required for full resistance to Pseudomonas syringae and affects jasmonate signalling.

Science.gov (United States)

Balagué, Claudine; Gouget, Anne; Bouchez, Olivier; Souriac, Camille; Haget, Nathalie; Boutet-Mercey, Stéphanie; Govers, Francine; Roby, Dominique; Canut, Hervé

2017-09-01

On microbial attack, plants can detect invaders and activate plant innate immunity. For the detection of pathogen molecules or cell wall damage, plants employ receptors that trigger the activation of defence responses. Cell surface proteins that belong to large families of lectin receptor kinases are candidates to function as immune receptors. Here, the function of LecRK-I.9 (At5g60300), a legume-type lectin receptor kinase involved in cell wall-plasma membrane contacts and in extracellular ATP (eATP) perception, was studied through biochemical, gene expression and reverse genetics approaches. In Arabidopsis thaliana, LecRK-I.9 expression is rapidly, highly and locally induced on inoculation with avirulent strains of Pseudomonas syringae pv. tomato (Pst). Two allelic lecrk-I.9 knock-out mutants showed decreased resistance to Pst. Conversely, over-expression of LecRK-I.9 led to increased resistance to Pst. The analysis of defence gene expression suggests an alteration of both the salicylic acid (SA) and jasmonic acid (JA) signalling pathways. In particular, LecRK-I.9 expression during plant-pathogen interaction was dependent on COI1 (CORONATINE INSENSITIVE 1) and JAR1 (JASMONATE RESISTANT 1) components, and JA-responsive transcription factors (TFs) showed altered levels of expression in plants over-expressing LecRK-I.9. A similar misregulation of these TFs was obtained by JA treatment. This study identified LecRK-I.9 as necessary for full resistance to Pst and demonstrated its involvement in the control of defence against pathogens through a regulation of JA signalling components. The role of LecRK-I.9 is discussed with regard to the potential molecular mechanisms linking JA signalling to cell wall damage and/or eATP perception. © 2016 BSPP AND JOHN WILEY & SONS LTD.

Yellow fever vaccine: comparison of the neurovirulence of new 17D-204 Stamaril™ seed lots and RK 168-73 strain.

Science.gov (United States)

Moulin, Jean-Claude; Silvano, Jérémy; Barban, Véronique; Riou, Patrice; Allain, Caroline

2013-07-01

The neurovirulence of two new candidate 17D-204 Stamaril™ working seed lots and that of two reference preparations were compared. The Stamaril™ working seed lots have been used for more than twenty years for the manufacturing of vaccines of acceptable safety and efficacy. The preparation designated RK 168-73 and provided by the Robert Koch Institute was used as a reference. It was confirmed that RK 168-73 strain was not a good virus control in our study because it has a very low neurovirulence regarding both the clinical and histopathological scores in comparison with Stamaril™ strain and is not representative of a vaccine known to be satisfactory in use. The results were reinforced by the phenotypic characterization by plaque assay demonstrating that RK 168-73 was very different from the Stamaril™ vaccine, and by sequencing results showing 4 mutations between Stamaril™ and RK 168-73 viruses leading to amino acid differences in the NS4B and envelop proteins. Copyright © 2013 The International Alliance for Biological Standardization. Published by Elsevier Ltd. All rights reserved.

Eesti lavastus "Põrgu wärk" võitis Balti teatrifestivalil viis auhinda

Index Scriptorium Estoniae

2006-01-01

Balti teatrifestivalil "OmaDraama 2006" nähtud etendustest said viis auhinda eestlased - Mart Kivastik näidendi "Põrgu Wärk" eest, Hendrik Toompere lavastuse eest, Harriet Toompere naisosatäitmise eest, Jan Uuspõld Wiiralti kehastamise eest ning Margus Prangel Tuglase osa eest

LecRK-V, an L-type lectin receptor kinase in Haynaldia villosa, plays positive role in resistance to wheat powdery mildew.

Science.gov (United States)

Wang, Zongkuan; Cheng, Jiangyue; Fan, Anqi; Zhao, Jia; Yu, Zhongyu; Li, Yingbo; Zhang, Heng; Xiao, Jin; Muhammad, Faheem; Wang, Haiyan; Cao, Aizhong; Xing, Liping; Wang, Xiue

2018-01-01

Plant sense potential microbial pathogen using pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMPs). The Lectin receptor-like kinase genes (LecRKs) are involved in various cellular processes mediated by signal transduction pathways. In the present study, an L-type lectin receptor kinase gene LecRK-V was cloned from Haynaldia villosa, a diploid wheat relative which is highly resistant to powdery mildew. The expression of LecRK-V was rapidly up-regulated by Bgt inoculation and chitin treatment. Its transcript level was higher in the leaves than in roots, culms, spikes and callus. Single-cell transient overexpression of LecRK-V led to decreased haustorium index in wheat variety Yangmai158, which is powdery mildew susceptible. Stable transformation LecRK-V into Yangmai158 significantly enhanced the powdery mildew resistance at both seedling and adult stages. At seedling stage, the transgenic line was highly resistance to 18 of the tested 23 Bgt isolates, hypersensitive responses (HR) were observed for 22 Bgt isolates, and more ROS at the Bgt infection sites was accumulated. These indicated that LecRK-V confers broad-spectrum resistance to powdery mildew, and ROS and SA pathways contribute to the enhanced powdery mildew resistance in wheat. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

Tek Millet, Tek Ses? Türk Konseyi Ülkelerinin Birleşmiş Milletler Genel Kurulu Oy Yakınlaşması, 1993-2011

OpenAIRE

Kaplan, Muhittin; Yuvacı, Abdullah; Amanov, Shatlyk

2015-01-01

Bu makale, CCTS veya Türk Konseyi olarak bilinen Türk Dili Konuşan Ülkeler İşbirliği Konseyi üyelerinin (Azerbaycan, Kazakistan, Kırgızistan ve Türkiye) Birleşmiş Milletler Genel Kurulundaki (UNGA) oylamalarda ne ölçüde uyumlu hareket ettiklerini incelemektedir. 1993 – 2011 dönemi Türk Konseyi ülkelerinin Birleşmiş Milletler Genel Kurulu oy yakınlaşması- nın analiz edildiği ve bunun tüm BM üyelerinin ortalamasıyla kıyaslandığı bu makalede, Türk Konseyi ülkelerinin dış politika meseleleriyle i...

Acute aortic regurgitation secondary to disk embolization of a Björk-Shiley prosthetic aortic valve.

Science.gov (United States)

Grande, Robert D; Katz, William E

2011-03-01

Having passed the 30th anniversary of the first implantation of a Björk-Shiley convexo-concave tilting mechanical valve, recognition of the life-threatening complication of strut fracture is not widespread. The authors report the case of a 48-year-old man with acute-onset chest pain and dyspnea found to have strut fracture and disk embolization of a 26-year-old Björk-Shiley prosthetic aortic valve. The value of echocardiography in the diagnosis of this condition is discussed. Copyright © 2010 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.

H.E. Dr Danilo Türk President of the Republic of Slovenia (second from right) visiting the ATLAS detector with, from left to right, Ambassador A. Logar, Spokesperson F. Gianotti, Director-General R. Heuer, First Lady B. Miklič Türk and ATLAS Slovenian national contactperson M. Mikuz.

CERN Multimedia

Maximilien Brice

2009-01-01

H.E. Dr Danilo Türk President of the Republic of Slovenia (second from right) visiting the ATLAS detector with, from left to right, Ambassador A. Logar, Spokesperson F. Gianotti, Director-General R. Heuer, First Lady B. Miklič Türk and ATLAS Slovenian national contactperson M. Mikuz.

Accelerated solution of non-linear flow problems using Chebyshev iteration polynomial based RK recursions

Energy Technology Data Exchange (ETDEWEB)

Lorber, A.A.; Carey, G.F.; Bova, S.W.; Harle, C.H. [Univ. of Texas, Austin, TX (United States)

1996-12-31

The connection between the solution of linear systems of equations by iterative methods and explicit time stepping techniques is used to accelerate to steady state the solution of ODE systems arising from discretized PDEs which may involve either physical or artificial transient terms. Specifically, a class of Runge-Kutta (RK) time integration schemes with extended stability domains has been used to develop recursion formulas which lead to accelerated iterative performance. The coefficients for the RK schemes are chosen based on the theory of Chebyshev iteration polynomials in conjunction with a local linear stability analysis. We refer to these schemes as Chebyshev Parameterized Runge Kutta (CPRK) methods. CPRK methods of one to four stages are derived as functions of the parameters which describe an ellipse {Epsilon} which the stability domain of the methods is known to contain. Of particular interest are two-stage, first-order CPRK and four-stage, first-order methods. It is found that the former method can be identified with any two-stage RK method through the correct choice of parameters. The latter method is found to have a wide range of stability domains, with a maximum extension of 32 along the real axis. Recursion performance results are presented below for a model linear convection-diffusion problem as well as non-linear fluid flow problems discretized by both finite-difference and finite-element methods.

Comparative evaluation of immunochromatographic dipstick test (ICT) rk39, soluble antigen ELISA and IFAT for the sero-diagnosis of visceral leishmaniasis in Morocco.

Science.gov (United States)

Mniouil, Meryem; Fellah, Hajiba; Amarir, Fatima; Sadak, Abderrahim; Et-Touys, Abdeslam; Bakri, Youssef; Moustachi, Aziza; Tassou, Fatima Zahraa; Hida, Mostapha; Lyagoubi, Mohamed; Adlaoui, El Bachir; Rhajaoui, Mohamed; Sebti, Faiza

2018-06-01

A rapid, sensitive and specific tool for detection of Leishmania infantum infection in Humans would be highly desirable, because it would allow control interventions in endemic areas of visceral leishmaniasis. This study was carried out at the Reference National Laboratory of Leishmaniasis (RNLL) in National Institute of Hygiene (NIH) Morocco, in order to evaluate the diagnostic potential of immunochromatographic dipstick test (ICT) rk39 in Moroccan suspected VL patients. A total of 49 admitted patients with strong clinical suspicion of VL and 40 healthy controls were investigated for the performance of the ICT rk39. Bone marrow smears were examined for microscopic detection of Leishmania amastigotes obtained from the admitted patients. Only PCR and smear positive cases were considered as gold standard as well as confirmed cases of VL. Out of 49 suspected patients, twenty four (48.9%) were found PCR and smear-positive and twenty three (46.9%) were positive for ICT rk39. Voluntary healthy controls, which included twenty persons from the endemic zone and twenty from non-endemic zone of VL, were found all negative for the strip test. The sensitivity in sera was 75% by ELISA and 87.5% by IFAT, compared with 95.8% for ICT rk39. Specificity was 95.8%, with both tests ELISA and IFAT, and 100% by ICT rk39 respectively. Present study findings again reinforce that the ICT rk39 is a simple, reliable and easy-to-perform non-invasive diagnostic tool for visceral leishmaniasis in the endemic area of Morocco. Copyright © 2018 Elsevier B.V. All rights reserved.

Yabancı Dil Türkçe Öğreten İngilizce Öğretmenleri İle Bir Durum İncelemesi: “Türkçe Balta Girmemiş Orman" A Case Study With English Teachers Teaching Turkish As A Foreign Languge: “Turkish An Untouched Forest”

Directory of Open Access Journals (Sweden)

Serra YAVUZ

2013-09-01

Full Text Available Learning Turkish as a foreign language has gained importanceand popularity in the past few decades around the world. As aconsequence of this growing demand, institutions are obliged to offermore courses for learners and train more effective educators of Turkishas a foreign language. Turkish is still being taught widely byacademicians who mostly have not received any training courses,seminars, teaching practice opportunities or even lesson observationopportunities before they enter this area of teaching. Turkish as aforeign language courses are mostly being taught by educators whohold Linguistics, Turkish Language and Literature, Turkish, English,French or German Language Education degrees. In this study, selfefficacybelief levels of English teachers who are teaching their nativelanguage, Turkish, as a foreign language was measured. Data wascollected through a survey, personal interviews and block lessonobservations. Collected data was used to determine the levels of selfefficacybeliefs, the effects of being a native speaker of the targetlanguage, and difficulties in teaching Turkish grammar. Results showthat even though they are the native speakers of Turkish, Englishteachers’ self-efficacy belief levels were low, and this state affects thechoice of in-class activities and other educational decisions of theparticular teachers. Son yıllarda dünyada yabancı dil olarak Türkçe öğrenmek isteyenlerin sayısındaki artış, ilgili eğitim kurumlarının bu alanda daha çok arzda bulunmasını, bu arzı sağlayabilmek için de donanımlı öğretmen yetiştirmesini zorunlu kılmıştır. Yabancı dil olarak Türkçe eğitimi günümüzde hâlâ anadili Türkçe olan ancak çoğunluğu Türkçenin yabancı dil olarak öğretilmesine yönelik bir eğitim almamış akademisyenler tarafından yürütülmektedir. Bu akademisyenler çoğunlukla Dilbilim, Türk Dili ve Edebiyatı, Türkçe, İngilizce, Fransızca, Almanca Öğretmenlikleri b

Beam dynamics issues in an extended relativistic klystron

International Nuclear Information System (INIS)

Giordano, G.; Li, H.; Goffeney, N.; Henestroza, E.; Sessler, A.; Yu, S.

1995-04-01

Preliminary studies of beam dynamics in a relativistic klystron were done to support a design study for a 1 TeV relativistic klystron two-beam accelerator (RK-TBA), 11.424 GHz microwave power source. This paper updates those studies. An induction accelerator beam is modulated, accelerated to 10 MeV, and injected into the RK with a rf current of about 1.2 kA. The main portion of the RK is the 300-m long extraction section comprise of 150 traveling-wave output structures and 900 induction accelerator cells. A periodic system of permanent quadrupole magnets is used for focusing. One and two dimensional numerical studies of beam modulation, injection into the main RK, transport and longitudinal equilibrium are presented. Transverse beam instability studies including Landau damping and the ''Betatron Node Scheme'' are presented

Valgas võtab maavanema ameti üle Kalev Härk / Maria-Elisa Rannajõe

Index Scriptorium Estoniae

Rannajõe, Maria-Elisa

2007-01-01

Valga maavanema kohusetäitjaks saab maavalitsuse arengu- ja planeeringuosakonna juhataja Kalev Härk, praegu maavanema kohuseid täitev Tõnis Lass läheb puhkusele. Valga maavanem Georg Trashanov on kriminaalmenetluse ajaks töökohalt kõrvaldatud

Radiographic detection of single-leg fracture in Björk-Shiley Convexo-Concave prosthetic valves: a phantom model study.

Science.gov (United States)

Gilchrist, I C; Cardella, J F; Fox, P S; Pae, W E; el-Ghamry Sabe, A A; Landis, J R; Localio, A R; Kunselman, A R; Hopper, K D

1997-02-01

Cineradiography can identify patients with single-leg fractured Björk-Shiley Convexo-Concave valves, although little is known about the sensitivity and specificity of this technique. We evaluated three normal and six (0 microm gap) single-leg fractured Björk-Shiley valves that were placed in a working phantom model. Valves were randomly imaged a total of 33 times and duplicated into a 120-valve series with a 1:9 ratio of abnormal/normal valves. Six reviewers independently graded each valve and demonstrated markedly different rates of identifying the fractured valves. Average sensitivity at the grade that clinically results in valve explanation was 47%. Among the normal valves, a correct identification was made 96% (range 91% to 99%) of the time. Present radiographic technology may have significant difficulty in identifying true single-leg fracture in Björk-Shiley valves with limb separations that are common among clinically explanted valves.

Türkiye Türkçesi Ağızlarında Lambdasizm Sigmatizm Meselesinin İzleri

OpenAIRE

YILDIZ, Hüseyin

2015-01-01

Lambdasizm / sigmasizm konusu gerek Türk lehçeleri arasında, gerekse Türkçeyle akraba olan diğer diller arasında tanıklanan örneklerden ortaya çıkmış problemlerdir. İçinde /l/ ünsüzü bulunan bazı kelimelerin bir başka dilde ya da lehçede /ş/’li olarak görülmesi, probleme sebep olan soruyu sordurmuştur: Hangisi daha arkaiktir? İlk olarak W. Schoot’un ortaya koyduğu bu problem hakkında Radloff, Gombocz, Németh, Benzing, Clauson, Meyer, Róna-Tas, Nauta, Scherner, Adamović, Ramstedt, Poppe, Räsän...

IgG and IgG subclasses antibody responses to rK39 in Leishmania donovani infections

International Nuclear Information System (INIS)

Daifalla, N.S.; El Hassan, A.M.

1998-01-01

Leishmania donovani infection cause a wide spectrum of human diseases ranging from self-healing subclinical infections to severe visceral leishmaniasis, post kal-azar dermal leishmaiasis, and mucosal leishmaiasis. The infection associated with high levels of anti-leishmania antibodies which offer a potential parameter for the serological diagnosis of L. donovani infection replacing the invasive parasitological methods. rK39, a cloned antigen of L. chagasis was reported to have high levels of anti-leishmania antibodies in Sudanese and American visceral leishmaniasis patients. In an assessment of rK39-ELISA in detecting L. donovani infection we found that the antigen detected visceral leishmaniasis, post kala-azar dermal leishmaniasis, and mucosal leismaniasis with the sensitives of 96.6%, 95.91% and 90.91% respectively. The test has the specificity of 96.7%. Further investigation of 25 visceral leishmaniasis patients showed elevated anti-rK39 antibody responses of IgG subclasses with IgG1 and IgG3 significantly higher than IgG4. igG3 showed the highest sensitivity (84.00%) whereas IgG1 showed the highest sensitivity (100%). The dynamics of the serological reactivity to rK39 in l.donovani infections will be discussed in relation to exposure, infection, cure and relapse.(Author)

Türk Çaylarının Nesnel Kalite Parametrelerine Göre Değerlendirilmesi

Directory of Open Access Journals (Sweden)

Huriye Wetherilt

2015-02-01

Full Text Available Bu çalışmada 12 farklı Türk çayı ile Hindistan, Seylan ve Rus çaylarında önemli kalite parametreleri (theaflavin, thearubigin, renk, parlaklık, azot, kafein, protein, nem, kül, suda çözünmeyen kül, asitte çözünmeyen kül, selüloz, karoten, fosfor, kalsiyum, potasyum, bakır, çinko, mangan, magnezyum, demir ve alüminyum düzeyleri nesnel kalite kontrol yöntemleri ile incelenmiştir. Türk çayları, bu parametreler için literatürde verilen sınırlara göre, kendi aralarında ve yabancı çaylarla karşılaştırılmıştır. Yukarıda verilen tüm kalite parametreleri göz önüne alındığında, bu araştırma kapsamında incelenen Türk çayları arasında en iyisinin ihraç için paketlenen Yeni Ekstre çayı olduğu belirlenmiştir. Bunu ikinci sırada ihraç için paketlenen Rize Turist çayı izlemiştir. Karton kutuda paketlenen ihraç Kamelya ve okula harman çayları kalite açısından sırasıyla üçüncü ve dördüncü en iyi Türk çayları olarak nitelendirilmiştir. Tüm örnekler arasında Hindistan Assam çayının, incelenen parametrelerin büyük çoğunluğuna göre en kalite çay olduğu saptanmıştır. Araştırma bulgularının ışığı altında, Türk çaylarının kalitelerinin iyileştirilmesi ve yabancı piyasada diğer çaylarla rekabet edebilmesi için hasat, işleme ve depolama sürecinde alınabilecek bazı önlemler için öneriler sunulmuştur.

The role of Tre6P and SnRK1 in maize early kernel development and events leading to stress-induced kernel abortion.

Science.gov (United States)

Bledsoe, Samuel W; Henry, Clémence; Griffiths, Cara A; Paul, Matthew J; Feil, Regina; Lunn, John E; Stitt, Mark; Lagrimini, L Mark

2017-04-12

Drought stress during flowering is a major contributor to yield loss in maize. Genetic and biotechnological improvement in yield sustainability requires an understanding of the mechanisms underpinning yield loss. Sucrose starvation has been proposed as the cause for kernel abortion; however, potential targets for genetic improvement have not been identified. Field and greenhouse drought studies with maize are expensive and it can be difficult to reproduce results; therefore, an in vitro kernel culture method is presented as a proxy for drought stress occurring at the time of flowering in maize (3 days after pollination). This method is used to focus on the effects of drought on kernel metabolism, and the role of trehalose 6-phosphate (Tre6P) and the sucrose non-fermenting-1-related kinase (SnRK1) as potential regulators of this response. A precipitous drop in Tre6P is observed during the first two hours after removing the kernels from the plant, and the resulting changes in transcript abundance are indicative of an activation of SnRK1, and an immediate shift from anabolism to catabolism. Once Tre6P levels are depleted to below 1 nmol∙g -1 FW in the kernel, SnRK1 remained active throughout the 96 h experiment, regardless of the presence or absence of sucrose in the medium. Recovery on sucrose enriched medium results in the restoration of sucrose synthesis and glycolysis. Biosynthetic processes including the citric acid cycle and protein and starch synthesis are inhibited by excision, and do not recover even after the re-addition of sucrose. It is also observed that excision induces the transcription of the sugar transporters SUT1 and SWEET1, the sucrose hydrolyzing enzymes CELL WALL INVERTASE 2 (INCW2) and SUCROSE SYNTHASE 1 (SUSY1), the class II TREHALOSE PHOSPHATE SYNTHASES (TPS), TREHALASE (TRE), and TREHALOSE PHOSPHATE PHOSPHATASE (ZmTPPA.3), previously shown to enhance drought tolerance (Nuccio et al., Nat Biotechnol (October 2014):1-13, 2015). The impact

Liderlik Oryantasyon Ölçeğinin Türkçeye Uyarlanması

Directory of Open Access Journals (Sweden)

Kenan ÖZCAN

2012-11-01

Full Text Available Örgüt iklimi örgütsel yapı ve yönetimin bir sonucudur. Çalışanların örgütün yapısı ve yöneticilerin liderlik davranışlarına dair algıları örgüt iklimi hakkında bir fikir vermektedir. Örgütsel iklime dair olumsuz algılar örgütte dengesiz, olumlu algılar ise dengeli bir yönetim yapısı bulunduğunu göstermektedir. Bu çalışma örgütsel yapı hakkında bilgi veren Thompson (2005 tarafından geliştirilen “Liderlik Oryantasyon Ölçeğinin” Türkçeye uyarlanmasını amaçlamaktadır. Ölçeğin orijinal halinde 32 madde ve dört alt boyut bulunmakta ve Türkçeye uyarlanan şekli de aynı formu korumuştur.  Ölçeğin Türkçeye uyarlanması sürecine,  Açımlayıcı Faktör Analizi (AFA için 300 ve Doğrulayıcı Faktör Analizi (DAF için 234 öğretmen katılmıştır. Ölçeğin uyarlanmasıyla ülkemizde yapılacak araştırmalarla elde edilen bulguların, aynı ölçekle farklı kültürlerde yapılan/yapılacak olan araştırma bulgularıyla karşılaştırılabilmesine olanak sağlayacağında, ölçeğin Türkçeye uyarlanmasının önemli olduğu söylenebilir. Anahtar sözcükler: örgüt iklimi, liderlik, örgüt yönetimi

Morte e ironia em “A exposição das rosas”, de István Örkény

Directory of Open Access Journals (Sweden)

Leonardo Francisco Soares

2009-03-01

Full Text Available Estudo da narrativa “A exposição das rosas”, de István Örkény, examinando o tema da morte e a problematização de sua representação. Nascido em 1912 e falecido em 1979, Örkény testemunhou de forma intensa e intrínseca as grandes convulsões que abalaram a Europa no século 20. Longe do panfleto, sua literatura tem como traço marcante a ironia. Na novela analisada, Iron Korom, um jovem e inexperiente diretor, tenta realizar um documentário sobre as horas finais de três pacientes desenganados, com o intuito de, nas suas palavras, ajudar os seus contemporâneos a compreenderem a experiência da morte. A partir do projeto de Korom, o texto de Örkény coloca-­nos diante de um confim: o limite da representação.

A flavor-safe composite explanation of $R_K$

CERN Document Server

Carmona, Adrian

2017-05-04

In these proceedings we discuss a flavor-safe explanation of the anomaly found in $R_K= {\\cal B}(B \\to K \\mu^+ \\mu^-)/{\\cal B}(B \\to K e^+ e^-)$ by LHCb, within the framework of composite Higgs models. We present a model featuring a non-negligible degree of compositeness for all three generations of right-handed leptons, which leads to a violation of lepton-flavor universality in neutral current interactions while other constraints from quark- and lepton-flavor physics are met. Moreoever, the particular embedding of the lepton sector considered in this setup provides a parametrically enhanded contribution to the Higgs mass that can weak considerably the need for ultra-light top partners.

50 miljoni kulutamise eesmärk : 50 miljonit tuleb kulutada ja kõik / Raimo Poom

Index Scriptorium Estoniae

Poom, Raimo

2007-01-01

Ministeeriumid kritiseerivad majandus- ja kommunikatsiooniministeeriumi kodutoetuse seaduse eelnõu, mille eesmärk on lahendada lasterikaste perede eluasemeprobleemid. Siim Valmar Kiisleri, Jürgen Ligi, majandus- ja kommunikatsiooniministeeriumi pressiesindaja Kalev Vapperi arvamusi. Vt. samas: Kadri Ibrus. Viielapseline pere laenu ei saa

TÜRK RUS BOKS MİLLİ TAKIMLARININ BAZI FİZYOLOJİK KAPASİTE VE ANTROPOMETRİK YAPILARININ KARŞILAŞTIRILMASI

OpenAIRE

ZORBA, Erdal; ZİYAGİL, M. Akif; ERDEMİR, İbrahim

1999-01-01

Buaraştırmanın amacı Türk ve Rus Boks Milli Takımlarının bazı fizyolojik kapasiteve antropometrik yapılarının karşılaştırılmasıdır. Çalışmaya katılan boksörlerkilolarına göre; hafif (50-60 kg), orta (60-70 kg) ve ağır (70-H2kg) sıkletolarak 3 gruba bölündüler ve Türk Milli Takımından 19, Rus Milli Takımından 17denek katıldı. Tüm deneklerin sırasıyla; yaş, vücut ağırlığı, boy, esneklik(otur-uzan), sistolik-diastolik kan basıncı, dinlenme kalp atımları, dikeysıçrama, vücut yağ yüzdeleri ve anae...

Estradiol modulates functional brain organization during the menstrual cycle : an analysis of interhemispheric inhibition.

OpenAIRE

Weis, S.; Hausmann, M.; Stoffers, B.; Vohn, R.; Kellermann, T.; Sturm, W.

2008-01-01

According to the hypothesis of progesterone-mediated interhemispheric decoupling (Hausmann and Güntürkün, 2000), functional cerebral asymmetries (FCAs), which are stable in men and change during the menstrual cycle in women, are generated by interhemispheric inhibition of the dominant on the nondominant hemisphere. The change of lateralization during the menstrual cycle in women might indicate that sex hormones play an important role in modulating FCAs. We used functional magnetic resonance i...

Progress report of the initiative on the Preservation of Records, Knowledge and Memory (RK and M) across Generations - March 2013 - March 2014

International Nuclear Information System (INIS)

2015-01-01

NEA member countries are currently developing deep geological disposal projects for radioactive waste and spent fuel. These facilities will be implemented and operated over several decades. Once closed, they are to remain safe for millennia. Geological repositories are designed to be intrinsically safe and final; safety is not to depend on human presence and intervention. However, there is no intention to forgo, at any time, records, knowledge, memory (RK and M) and awareness of the repository and the waste it contains. Besides, specific requirements may have to be fulfilled in the area of RK and M based on national legislation and regulation, e.g. in the area of preventing human intrusion, favouring retrievability of the waste, or to simply allow future generations to make their own informed decisions about the waste. Additionally, host communities and regions have indicated a strong interest in that appropriate provisions exist for preserving detailed information about the repository for as long as possible. As a result, national programmes are actively seeking to improve their understanding of the preservation of RK and M about radioactive waste across generations and to implement the necessary provisions. The NEA Radioactive Waste Management Committee (RWMC) initiative on the Preservation of RK and M across Generations was launched to meet the demands from member countries for facilitating exchange and fostering reflection in this area, including formulating common approaches. This initiative has as its focus the period of time after repository closure; another initiative, RepMet, deals with the period before closure. There is no single mechanism or technique that, by itself, would achieve the preservation of RK and M over centuries and millennia. Rather, an integrated set of mechanisms and techniques - technical, administrative and societal - is needed to address the various timescales and to support one another. The RK and M initiative started in 2011 with

Modeling of noise pollution and estimated human exposure around İstanbul Atatürk Airport in Turkey.

Science.gov (United States)

Ozkurt, Nesimi; Sari, Deniz; Akdag, Ali; Kutukoglu, Murat; Gurarslan, Aliye

2014-06-01

The level of aircraft noise exposure around İstanbul Atatürk Airport was calculated according to the European Noise Directive. These calculations were based on the actual flight data for each flight in the year 2011. The study area was selected to cover of 25km radius centered on the Aerodrome Reference Point of the airport. The geographical data around İstanbul Atatürk Airport was used to prepare elevation, residential building, auxiliary building, hospital and school layers in SoundPlan software. It was found that 1.2% of the land area of İstanbul City exceeds the threshold of 55dB(A) during daytime. However, when the exceedance of threshold of 65dB(A)is investigated, the affected area is found quite small (0.2% of land area of city). About 0.3% of the land area of İstanbul City has noise levels exceeding 55dB(A) during night-time. Our results show that about 4% of the resident population was exposed to 55dB(A) or higher noises during daytime in İstanbul. When applying the second threshhold criteria, nearly 1% of the population is exposed to noise levels greater than 65dB(A). At night-time, 1.3% of the population is exposed to 55dB(A) or higher noise levels. © 2013.

An rK28-Based Immunoenzymatic Assay for the Diagnosis of Canine Visceral Leishmaniasis in Latin America

Science.gov (United States)

Lauricella, Marta Alicia; Maidana, Cristina Graciela; Frias, Victoria Fragueiro; Romagosa, Carlo M.; Negri, Vanesa; Benedetti, Ruben; Sinagra, Angel J.; Luna, Concepcion; Tartaglino, Lilian; Laucella, Susana; Reed, Steven G.; Riarte, Adelina R.

2016-01-01

Direct observation of Leishmania parasites in tissue aspirates has shown low sensitivity for the detection of canine visceral leishmaniasis (VL). Therefore in the last quarter century immunoenzymatic tests have been developed to improve diagnosis. The purpose of this study was to develop a fast recombinant K28 antigen, naked-eye qualitative enzyme-linked immunosorbent assay (VL Ql-ELISA) and a quantitative version (VL Qt-ELISA), and to display it in a kit format, whose cutoff value (0.156) was selected as the most adequate one to differentiate reactive from nonreactive samples. Considering 167 cases and 300 controls, sensitivity was 91% for both assays and specificity was 100% and 98.7% in Ql-ELISA and Qt-ELISA, respectively. Positive predictive values were 100% and 97.4% for Ql-ELISA and Qt-ELISA, respectively, and negative predictive values were 95.2% for both ELISAs. Reagent stability, reliability studies, including periodic repetitions and retest of samples, cutoff selection, and comparison of rK28 ELISAs with rK39 immunochromatographic test, were the international criteria that supported the quality in both kits. The performance of both ELISA kits in this work confirmed their validity and emphasized their usefulness for low-to-medium complexity laboratories. PMID:27162270

Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses1[OPEN

Science.gov (United States)

Waadt, Rainer; Manalansan, Bianca; Rauniyar, Navin; Munemasa, Shintaro; Booker, Matthew A.; Brandt, Benjamin; Waadt, Christian; Nusinow, Dmitri A.; Kay, Steve A.; Kunz, Hans-Henning; Schumacher, Karin; DeLong, Alison; Yates, John R.; Schroeder, Julian I.

2015-01-01

The plant hormone abscisic acid (ABA) controls growth and development and regulates plant water status through an established signaling pathway. In the presence of ABA, pyrabactin resistance/regulatory component of ABA receptor proteins inhibit type 2C protein phosphatases (PP2Cs). This, in turn, enables the activation of Sucrose Nonfermenting1-Related Protein Kinases2 (SnRK2). Open Stomata1 (OST1)/SnRK2.6/SRK2E is a major SnRK2-type protein kinase responsible for mediating ABA responses. Arabidopsis (Arabidopsis thaliana) expressing an epitope-tagged OST1 in the recessive ost1-3 mutant background was used for the copurification and identification of OST1-interacting proteins after osmotic stress and ABA treatments. These analyses, which were confirmed using bimolecular fluorescence complementation and coimmunoprecipitation, unexpectedly revealed homo- and heteromerization of OST1 with SnRK2.2, SnRK2.3, OST1, and SnRK2.8. Furthermore, several OST1-complexed proteins were identified as type 2A protein phosphatase (PP2A) subunits and as proteins involved in lipid and galactolipid metabolism. More detailed analyses suggested an interaction network between ABA-activated SnRK2-type protein kinases and several PP2A-type protein phosphatase regulatory subunits. pp2a double mutants exhibited a reduced sensitivity to ABA during seed germination and stomatal closure and an enhanced ABA sensitivity in root growth regulation. These analyses add PP2A-type protein phosphatases as another class of protein phosphatases to the interaction network of SnRK2-type protein kinases. PMID:26175513

Functional analysis of duplicated Symbiosis Receptor Kinase (SymRK) genes during nodulation and mycorrhizal infection in soybean (Glycine max).

Science.gov (United States)

Indrasumunar, Arief; Wilde, Julia; Hayashi, Satomi; Li, Dongxue; Gresshoff, Peter M

2015-03-15

Association between legumes and rhizobia results in the formation of root nodules, where symbiotic nitrogen fixation occurs. The early stages of this association involve a complex of signalling events between the host and microsymbiont. Several genes dealing with early signal transduction have been cloned, and one of them encodes the leucine-rich repeat (LRR) receptor kinase (SymRK; also termed NORK). The Symbiosis Receptor Kinase gene is required by legumes to establish a root endosymbiosis with Rhizobium bacteria as well as mycorrhizal fungi. Using degenerate primer and BAC sequencing, we cloned duplicated SymRK homeologues in soybean called GmSymRKα and GmSymRKβ. These duplicated genes have high similarity of nucleotide (96%) and amino acid sequence (95%). Sequence analysis predicted a malectin-like domain within the extracellular domain of both genes. Several putative cis-acting elements were found in promoter regions of GmSymRKα and GmSymRKβ, suggesting a participation in lateral root development, cell division and peribacteroid membrane formation. The mutant of SymRK genes is not available in soybean; therefore, to know the functions of these genes, RNA interference (RNAi) of these duplicated genes was performed. For this purpose, RNAi construct of each gene was generated and introduced into the soybean genome by Agrobacterium rhizogenes-mediated hairy root transformation. RNAi of GmSymRKβ gene resulted in an increased reduction of nodulation and mycorrhizal infection than RNAi of GmSymRKα, suggesting it has the major activity of the duplicated gene pair. The results from the important crop legume soybean confirm the joint phenotypic action of GmSymRK genes in both mycorrhizal and rhizobial infection seen in model legumes. Copyright © 2015 Elsevier GmbH. All rights reserved.

Intraoperative echocardiography of a dislodged Björk-Shiley mitral valve disc.

Science.gov (United States)

Tanaka, M; Abe, T; Takeuchi, E; Watanabe, T; Tamaki, S

1991-02-01

The successful management of a patient who suffered an outlet strut fracture of a Björk-Shiley 60-degree convexo-concave mitral valve prosthesis is reported. Emergency operation was life-saving. Preoperative echocardiography assisted in making a prompt diagnosis, and intraoperative echocardiography allowed the detection and removal of the dislodged disc from the left ventricle at the time of the operation. The role of intraoperative echocardiography in the diagnosis of prosthetic strut fracture is emphasized.

Interfacial modulation of urban affect

DEFF Research Database (Denmark)

Samson, Kristine

Urban culture can increasingly be understood as interface culture (Munster) in which urban design, cultural institutions and architecture increasingly operate as affective interfaces distributing and mediating human perception, consumption and social encounters. As noted by Amin and Thrift (2002......, Massey 2006), they also exclude in depth social and human interaction. Through analysis of three examples of urban affective interfaces (The High Line in New York, Superkilen in Copenhagen and Stålsat By, Frederiksværk, the paper examines how affective urban interfaces modulate and mediate urban...... environments as bodily and sensorial experiences. It asks what is mediated through the interface – whether the. It also asks, what is excluded when urban environments become affective interfaces in the global networked city. Whereas urban interface collect and distribute the bodily and sensible in relational...

Thermochemical treatment of the pay zone in the well RK-3

Energy Technology Data Exchange (ETDEWEB)

Labudovic, V

1970-02-01

The elements are given for the calculation of the thermochemical treatment of the Well RK-3. From the diagram, the Mg and HCl reaction velocity vs. pressure and the temperature vs. the quantity of the reacted CaCO/sub 3/ can be read out. These are important elements for the calculation of a thermochemical treatment. A comparison of calculated and measured temperatures and the factors influencing the heat conductivity of the formation rock is given. The heating range at formation depths is calculated. The relation quantity of warm acid vs. injection pressure also is given.

Differential expression of poplar sucrose nonfermenting1-related protein kinase 2 genes in response to abiotic stress and abscisic acid.

Science.gov (United States)

Yu, Xiang; Takebayashi, Arika; Demura, Taku; Ohtani, Misato

2017-09-01

Knowledge on the responses of woody plants to abiotic stress can inform strategies to breed improved tree varieties and to manage tree species for environmental conservation and the production of lignocellulosic biomass. In this study, we examined the expression patterns of poplar (Populus trichocarpa) genes encoding members of the sucrose nonfermenting1-related protein kinase 2 (SnRK2) family, which are core components of the abiotic stress response. The P. trichocarpa genome contains twelve SnRK2 genes (PtSnRK2.1- PtSnRK2.12) that can be divided into three subclasses (I-III) based on the structures of their encoded kinase domains. We found that PtSnRK2s are differentially expressed in various organs. In MS medium-grown plants, all of the PtSnRK2 genes were significantly upregulated in response to abscisic acid (ABA) treatment, whereas osmotic and salt stress treatments induced only some (four and seven, respectively) of the PtSnRK2 genes. By contrast, soil-grown plants showed increased expression of most PtSnRK2 genes under drought and salt treatments, but not under ABA treatment. In soil-grown plants, drought stress induced SnRK2 subclass II genes in all tested organs (leaves, stems, and roots), whereas subclass III genes tended to be upregulated in leaves only. These results suggest that the PtSnRK2 genes are involved in abiotic stress responses, are at least partially activated by ABA, and show organ-specific responses.

CesRK, a two-component signal transduction system in Listeria monocytogenes, responds to the presence of cell wall-acting antibiotics and affects beta-lactam resistance

DEFF Research Database (Denmark)

Kallipolitis, Birgitte H; Ingmer, Hanne; Gahan, Cormac G

2003-01-01

Listeria monocytogenes is a food-borne pathogen that can cause a variety of illnesses ranging from gastroenteritis to life-threatening septicemia. The beta-lactam antibiotic ampicillin remains the drug of choice for the treatment of listeriosis. We have previously identified a response regulator...... of L. monocytogenes to tolerate ethanol and cell wall-acting antibiotics of the beta-lactam family. Furthermore, CesRK controls the expression of a putative extracellular peptide encoded by the orf2420 gene, located immediately downstream from cesRK. Inactivation of orf2420 revealed that it contributes...... to ethanol tolerance and pathogenesis in mice. Interestingly, we found that transcription of orf2420 was strongly induced by subinhibitory concentrations of various cell wall-acting antibiotics, ethanol, and lysozyme. The induction of orf2420 expression was abolished in the absence of CesRK. Our data suggest...

The Role of MAPK Modules and ABA during Abiotic Stress Signaling

KAUST Repository

Zélicourt, Axel de

2016-05-01

To respond to abiotic stresses, plants have developed specific mechanisms that allow them to rapidly perceive and respond to environmental changes. The phytohormone abscisic acid (ABA) was shown to be a pivotal regulator of abiotic stress responses in plants, triggering major changes in plant physiology. The ABA core signaling pathway largely relies on the activation of SnRK2 kinases to mediate several rapid responses, including gene regulation, stomatal closure, and plant growth modulation. Mitogen-activated protein kinases (MAPKs) have also been implicated in ABA signaling, but an entire ABA-activated MAPK module was uncovered only recently. In this review, we discuss the evidence for a role of MAPK modules in the context of different plant ABA signaling pathways. Abiotic stresses impact average yield in agriculture by more than 50% globally.Since ABA is a key regulator of abiotic stress responses, an understanding of its functioning at the molecular level is essential for plant breeding. Although the ABA core signaling pathway has been unraveled, several downstream events are still unclear.MAPKs are involved in most plant developmental stages and in response to stresses. Several members of the MAPK family were shown to be directly or indirectly activated by the ABA core signaling pathway.Recent evidence shows that the complete MAP3K17/18-MKK3-MPK1/2/7/14 module is under the control of ABA, whose members are under the transcriptional and post-translational control of the ABA core signaling pathway. © 2016 Elsevier Ltd.

[Late outlet strut fracture of an aortic Björk-Shiley and embolization of the prosthetic disc].

Science.gov (United States)

Brochet, E; Bougis de Brux, M A; Assayag, P; Benacin, Y; Gamerman, G; Guerot, C; Valère, P E

1988-09-01

A new case of late fracture of an outlet strut in a convexo-concave Björk-Shiley valve is reported. The fracture occurred 6 years after aortic implantation of the valve and was responsible for aorto-iliac embolization by the prosthetic disc and death of the patient from cardiogenic shock. This not uncommon complication of the Björk-Shiley valve prosthesis is usually ascribed to the relative fragility of its outlet strut welded to the metallic ring and subjected to strong pressures. Although most cases were observed within the first two years of prosthetic valve insertion, and mainly with valves manufactured in 1981 and 1982, our case and a few others demonstrate the possibility of late rupture. Cardiologists must be aware of this possible complication, since in some favourable cases it can be diagnosed at an early stage and the patient's life can be saved by an emergency operation.

Männilinna veevärk sai korraga kaks peremeest : senine operaator valmistub Elvaga kohut käima / Martin Pau

Index Scriptorium Estoniae

Pau, Martin, 1975-

2010-01-01

Elva linnavolikogu otsusega pidanuks omavalitsuste loodud firmast Emajõe Veevärk saama 1. juulil Elva veevärgi haldaja, kuid senine majandaja Aqua & Waste Services (AWS) keeldub võtmeid üle andmast

Entre Lilith y Eva: Björk canta E. E. Cummings

Directory of Open Access Journals (Sweden)

Jordi Mas López

2016-05-01

del poeta norteamericano en Sun In My Mouth y el resto de composiciones de Vespertine. Frente a la inequívoca exaltación del héroe solar de Cummings, Björk utiliza una mirada femenina que duda entre los referentes de Lilith, la mujer que encuentra su libertad fuera de la sociedad, y Eva, aquella cuya sumisión es socialmente productiva. El resultado es un discurso de gran valor artístico, pero sujeto, en lo ideológico, a las limitaciones que imponen los motivos de partida

Source/ sink interactions underpin crop yield: the case for trehalose 6-phosphate/ SnRK1 in improvement of wheat

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Matthew ePaul

2014-08-01

Full Text Available Considerable interest has been evoked by the analysis of the regulatory pathway in carbohydrate metabolism and cell growth involving trehalose (TRE. TRE is at small concentrations in mesophytes such as Triticum aestivum. Studies of TRE metabolism, and genetic modification of it, have shown a very wide and important role of the pathway in regulation of many processes in development, growth and photosynthesis. It has now been established that trehalose 6-phosphate (T6P, is formed from glucose-6-phosphate and UDP-glucose, derived from sucrose, by the action of trehalose phosphate synthase (TPS and broken down by trehalose-6-phosphate phosphatase (TPP providing for subtle regulation. The concentration of T6P increases with sucrose concentration. Many of the effects of T6P on metabolism and growth occur via the interaction of T6P with the SnRK1 protein kinase system. A large concentration of sucrose increases T6P and thereby inhibits SnRK1, so stimulating growth of cells and their metabolism. The T6P/SnRK1 mechanism offers an important new view of how the distribution of assimilates to organs, such as developing cereal grains, is achieved. Changing T6P concentrations by genetically modifying TPS and TPP has altered photosynthesis, sugar metabolism, growth and development which affect responses to, and recovery from, environmental factors. This review briefly summarizes the factors determining, and limiting, yield of wheat, particularly mass/grain which is highly conserved. The interactions between the source and sink relations are addressed together with how T6P/SnRK1 might function to determine grain number, size, and yield. The possibility of how these might be increased by modifying trehalose metabolism is considered. Cereal yields globally are not increasing and careful targeting of T6P may offer a way of optimizing grain growth and thus increasing yield in wheat.

Türkçe Sözlükteki Akrabalık Adlarının Tasnifi Classification Of Relatives’ Names In Turkish Dictionaries

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Selim EMİROĞLU

2012-12-01

Full Text Available Turkish is one of the richest languages on the world for the number of relatives’ names it has. While there exist many words which denote relatives in Turkish, one word may express several relatives’ names in other languages. This shows both the richness of Turkish and the importance given to relatives’ relations. Turkish society has advanced and powerful relatives's relations. Through these relationships, solidarity, tolerance, cooperation and sharing of problemsare targeted. Relatives’s relations are extended through marriage,adoption and other forms of relationship than blood relationship. Therehave been many publications and researches on relatives’ names inTurkish. We want to contribute to these publications having a look atand classifying the vocabulary from the Modern Turkish Dictionary. Inthis work the Turkish Dictionary which was published as the 11thprinting by Turkish Language Institution in 2012 and the ModernTurkish Dictionary are investigated. A particular dictionary searchingmodel has been used and names have been classified. We can findapproximately 150 relatives’ names. These are classified as related tosynonyms of relatives’ names, related to being elder, younger, related tosex, related to closeness of relation, related to oneself and fosterparents, related to cultural closeness and traditions, related to men andwomen, related to the formation by father, mother and sibling, relatedto marital status, related to one word may express several relatives’names, related to using with plural and singular meanings, related tostructure of the relatives’ names, related to Turkish, foreign languageand mixed language. Türkçe, akrabalık bildiren sözcükler bakımından dünyanın en zengin dillerinden biridir. Türkçede akrabalık ilişkilerini ifade eden pek çok sözcük bulunurken başka dillerde bir sözcükle birden fazla akrabalık isminin karşılandığı görülür. Bu durum, Türkçenin zenginliği kadar Türk

47 CFR 2.1047 - Measurements required: Modulation characteristics.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Measurements required: Modulation characteristics. 2.1047 Section 2.1047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY... Certification § 2.1047 Measurements required: Modulation characteristics. (a) Voice modulated communication...

OLDTURKISHMEDICINE(XIV. - XVI. CENTURIESPROCEDURES FORMEASURINGAND DIMENSIONS ESKİ TÜRK TIBBINDA (XIV. - XVI. YÜZYILLAR ÖLÇÜLER VE ÖLÇME USULLERİ

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Gürkan GÜMÜŞATAM

2012-01-01

Full Text Available Turkishhistory of science, and with it the language ofsciencehas advancedthe course ofTurkishXIV.-XV.centurymedicalbooksterms of the datacontainsrichdata. Theimportanceof scientificworkswrittenin thiscenturyTurkishphysiciansin the works ofthe eraby puttingadministratorsin favor ofTurkish,complied withrequests. In this way,Turkishas the language ofsciencehas grown. Since theTurkishworks ofwritingfromamong those wholivedcenturiesphysicianshaveindicated. Centuries,written inplain languageratherthanthe worksnextpostin the works ofthe erathatthe presence ofdifferenttypes offace, observethe waysof their usage. The presence oftherelevanttermsofthesedimensionsandscalesare also available. The names given tounitsof measure, scales, and their useof suchwords inthe relevant departmentsin terms ofreachingasource ofpharmaceuticalproductions. The majority ofdetectionand usesthese termsfromArabicand Persianformedthe subject ofthisreview. The datasetwasselectedsixmedicalbook. As a result,Turkish,Arabicand Persianas well asinclusionof measurementunitsby using thedrawingsinthe waysof expressionis the resulthad been reached. Türk bilim tarihi ve onunla birlikte gelişme göstermiş Türk bilim dilinin seyri XIV.-XVI. yüzyıl tıp kitaplarındaki veriler bakımından zengin bulgular içerir. İlmî eserlerin Türkçe yazılmasına önem gösterilen bu dönemde hekimler Türkçeden yana tavır koyarak devrin yöneticilerinin isteklerine uymuşlardır. Bu sayede Türkçe bilim dili olarak gelişme göstermiştir. Eserlerini Türkçe yazmaktan yana olanlar arasında belirtilen yüzyıllar arasında yaşamış hekimler de vardır. Sonraki yüzyılllarda yazılmış eserlere nazaran oldukça yalın bir dille kaleme alınmış devrin eserlerinde değişik türden söz varlığıyla karşılaşmakta, bunların kullanım yollarını gözlenebilmektedir. Bu söz varlığı arasında ölçüler ve ölçeklerle ilgili terimler de bulunur. Ölçü birimlerine verilen adlar, �

THE BEATLES 2.1

DEFF Research Database (Denmark)

Nielsen, Steen Kaargaard

2010-01-01

Blog-essay publiceret på følgende web-adresse: www.avlyt.dk/2010/04/the-beatles-2-1-om-emis-forvaltning-af-the-fab-fours-lydværk-og-værklyd......Blog-essay publiceret på følgende web-adresse: www.avlyt.dk/2010/04/the-beatles-2-1-om-emis-forvaltning-af-the-fab-fours-lydværk-og-værklyd...

THE TRANSLATING PROBLEMS OF CONTEMPORARY TURKISH DIALECTS (BETWEEN THE NEW UYGUR TURKISH DIALECT AND TURKEY TURKISH DIALECT ÇAĞDAŞ TÜRK ŞİVELERİ ARASINDA AKTARMA MESELELERİ (YENİ UYGUR TÜRKÇESİ – TÜRKİYE TÜRKÇESİ ÖRNEĞİ

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Dr. M. Fatih ALKAYIŞ

2009-05-01

Full Text Available The translating of the books, writing with Contemporary Turkish Dialects, requires some attentions about the suffixes, words, concepts and centences to get an impressive form. By this way counfusions of meaning, between the Turkish Dialects, can be prevented.The New Uygur Turkish Dialect, thought as an Eastern Turkish Dialect at the classification of Turkish Language, is nearer to the characteristics of Old Turkish Language according to the Turkey Turkish Dialect, thought as a western Turkish Dialects. We can get a classification of translating problems, between the New Uygur Language and Turkey Turkish Language, in those titles: Verb moods, participles, gerundiums.With the solving of the problems between Contemporary Turkish Dialects, Turkish world will understand each other well, and also will be nearer. Çağdaş Türk şiveleriyle yazılmış eserleri bir şiveden başka bir şiveye aktarırken dikkat edilmesi gereken hususların başında “ek, kelime, kavram ve cümleleri” aynı etkiyi yaratacak biçimde çevirmek gelmektedir. Bu sayede anlam veya şekil bulanıklığı ortadan kalkar.Türk şivelerinin tasnifinde Doğu Türkçesinin bir kolu olarak kabul edilen Yeni Uygur Türkçesi, Batı Türkçesi içerisinde yer alan Türkiye Türkçesine oranla Eski Türkçenin şekil özelliklerine daha yakındır. Yeni Uygur Türkçesi ile Türkiye Türkçesi arasındaki aktarma meselelerini şu konular üzerinde ele alabiliriz: Fiil kipleri, sıfat-fiiller, zarf-fiiller. Çağdaş Türk şiveleri arasındaki aktarma meselelerinin çözümüyle Türk Dünyası birbirini daha iyi anlayacak ve birbirine daha çok yakınlaşacaktır.

Elective removal of convexo-concave Björk-Shiley valves.

Science.gov (United States)

Rajesh, P B; Smith, G H; Lawford, P V; Black, M M

1994-08-01

Replacement has been an accepted method for treating advanced cardiac valvular disease for more than 25 years. However, the perfect prosthesis has yet to be developed, judging by the number of devices available. A prosthesis that initially appears promising may cause problems in due course, and indeed some devices have been modified or withdrawn from clinical use. A notable example of a prosthetic valve that has give problems is the Björk-Shiley convexo-concave prosthesis, some models of which have undergone mechanical failure due to strut fracture. We report the elective removal of such a valve and the subsequent examination of the prosthesis. The results of this examination suggest that a policy of elective removal is justified.

Türkçe Öğretmeni Adaylarının Dinlerken Not Alma Stilleri / Turkish Language Teacher Candidates’ Note-Taking Styles while Listening

OpenAIRE

Gürkan TABAK; Adnan KARADÜZ

2016-01-01

Bu araştırma, Türkçe öğretmeni adaylarının dinlerken not alma stillerinin tespit edilmesi amacıyla gerçekleştirilmiştir. Bu araştırmada temel nitel çalışma deseni uygulanarak gerçekleştirilmiştir. Araştırmanın katılımcılarını, 2013–2014 eğitim-öğretim yılı güz döneminde Erciyes Üniversitesi Eğitim Fakültesi Türkçe öğretmenliği bölümü üçüncü sınıfa devam eden 22 Türkçe öğretmeni adayı oluşturmuştur. Katılımcıların belirlenmesinde kolay ulaşılabilir durum ve maksimum çeşitlilik örneklemelerinde...

Strut fracture and disc embolization of a Björk-Shiley mitral valve prosthesis: localization of embolized disc by computerized axial tomography.

Science.gov (United States)

Larrieu, A J; Puglia, E; Allen, P

1982-08-01

The case of a patient who survived strut fracture and embolization of a Björk-Shiley mitral prosthetic disc is presented. Prompt surgical treatment was directly responsible for survival. In addition, computerized axial tomography of the abdomen aided in localizing and retrieving the embolized disc, which was lodged at the origin of the superior mesenteric artery. A review of similar case reports from the literature supports our conclusions that the development of acute heart failure and absent or muffled prosthetic heart sounds in a patient with a Björk-Shiley prosthetic heart valve inserted prior to 1978 should raise the possibility of valve dysfunction and lead to early reoperation.

JAPON VE TÜRK MODERNLEŞMELERİNİN KARŞILAŞTIRMALI TARİHİ ÜZERİNE BİR DEĞERLENDİRME GERÇEKTEN “JAPON MUCİZESİ” vs. “TÜRK USÛLÜ” MÜ? / A REVIEW ON COMPARATIVE HISTORY OF JAPANESE AND TURKISH MODERNIZATION IS IT REALLY “JAPANESE MIRACLE” vs. “ALATURCA”?

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Hasan AKSAKAL

2012-07-01

Full Text Available Bu çalışma, ‘Batı dışı modernlik’ kavramı bağlamında Türk ve Japon modernleşmelerini ele almaktadır. Batılılaşmadan modernleşmenin mümkün olduğuna inanan Türk muhafazakâr düşüncesi, Japonya’yı, tanıdığı ilk günden itibaren bir model olarak görmüştür. Buna göre, Japonya, gelenek ve değerlerinden taviz vermeden modernleşmeyi başarmıştır. Bu uzak ülkenin ekonomik dinamizminden etkilenen Türk entelektüeli, “Japon mucizesi”ne derin bir saygı ve hayranlık duymuştur. Ancak, Meiji Restorasyonu baz alınarak Japon modernleşme tarihi ele alındığında, batılılaşma sorununun toplumsal ve kültürel yaşamda nasıl bir etkide bulunduğu ve Japon düşüncesinde ne gibi değişimlere yol açtığı anlaşılmaktadır. Muhafazakâr modernleşmeyle aşırı batılılaşma arasında cereyan eden salınım, Türk modernleşmesiyle kıyaslama yapmayı anlamlı kılmaktadır. Bu konuda yaptığımız değerlendirmede, Osmanlı-Türk modernleşmesiyle -özellikle II. Abdülhamid ve Atatürk dönemleri dikkate alınarak- karşılaştırıldığında, “Japon mucizesi”nin, sanılandan görece başarısız olduğu ve “alaturka” modernleşmeden çok da farklı olmadığı görülmektedir. Bununla birlikte çalışmada, çeşitli reform örnekleri ve dönemsel-yapısal özellikler, tarihsel gelişmeler çerçevesinde ele alınarak değerlendirilmekte ve iki ülkenin siyasal-kültürel deneyimlerine ilişkin bazı tespitlerde bulunulmaktadır.

SNF1-related protein kinases 2 are negatively regulated by a plant-specific calcium sensor.

Science.gov (United States)

Bucholc, Maria; Ciesielski, Arkadiusz; Goch, Grażyna; Anielska-Mazur, Anna; Kulik, Anna; Krzywińska, Ewa; Dobrowolska, Grażyna

2011-02-04

SNF1-related protein kinases 2 (SnRK2s) are plant-specific enzymes involved in environmental stress signaling and abscisic acid-regulated plant development. Here, we report that SnRK2s interact with and are regulated by a plant-specific calcium-binding protein. We screened a Nicotiana plumbaginifolia Matchmaker cDNA library for proteins interacting with Nicotiana tabacum osmotic stress-activated protein kinase (NtOSAK), a member of the SnRK2 family. A putative EF-hand calcium-binding protein was identified as a molecular partner of NtOSAK. To determine whether the identified protein interacts only with NtOSAK or with other SnRK2s as well, we studied the interaction of an Arabidopsis thaliana orthologue of the calcium-binding protein with selected Arabidopsis SnRK2s using a two-hybrid system. All kinases studied interacted with the protein. The interactions were confirmed by bimolecular fluorescence complementation assay, indicating that the binding occurs in planta, exclusively in the cytoplasm. Calcium binding properties of the protein were analyzed by fluorescence spectroscopy using Tb(3+) as a spectroscopic probe. The calcium binding constant, determined by the protein fluorescence titration, was 2.5 ± 0.9 × 10(5) M(-1). The CD spectrum indicated that the secondary structure of the protein changes significantly in the presence of calcium, suggesting its possible function as a calcium sensor in plant cells. In vitro studies revealed that the activity of SnRK2 kinases analyzed is inhibited in a calcium-dependent manner by the identified calcium sensor, which we named SCS (SnRK2-interacting calcium sensor). Our results suggest that SCS is involved in response to abscisic acid during seed germination most probably by negative regulation of SnRK2s activity.

System of automatic control over data Acquisition and Transmission to IGR NNC RK Data Center

International Nuclear Information System (INIS)

Komarov, I.I.; Gordienko, D.D.; Kunakov, A.V.

2005-01-01

Automated system for seismic and acoustic data acquisition and transmission in real time was established in Data Center IGR NNC RK, which functions very successively. The system monitors quality and volume of acquired information and also controls the status of the system and communication channels. Statistical data on system operation are accumulated in created database. Information on system status is reflected on the Center Web page. (author)

Optimization of L(+)-Lactic Acid Fermentation Without Neutralisation of Rhizopus Oryzae Mutant RK02 by Low-Energy Ion Implantation

International Nuclear Information System (INIS)

Li Wen; Wang Tao; Yang Yingge; Liu Dan; Fan Yonghong; Wang Dongmei; Yang Qian; Yao Jianming; Zheng Zhiming; Yu Zengliang

2008-01-01

In order to get an industrial strain which can yield a high concentration of lactic acid for ISPR (in situ product removal), the original strain Rhizopus oryzae RE3303 was mutated by low-energy ion beam implantation. A mutant RK02 was screened, and the factors such as the substrate concentration, nitrogen source concentration, inoculum size, seed age, aeration and temperature that affect the production of lactic acid were studied in detail. Under optimal conditions, the maximum concentration of L(+)-lactic acid reached 34.85 g/L after 30 h shake-flask cultivation without adding any neutralisation (5% Glucose added), which was a 146% increase in lactic acid production after ion implantation compared with the original strain. It was also shown that RK02 can be used in ISPR to reduce the number of times of separation.

Gök Türk Tarihi Coğrafyası

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Anıl Yılmaz

2015-07-01

Full Text Available Gök Türk çalışmalarında az değinilen konulardan biri, Türk kültürünü besleyen kaynakların alt yapısıdır. Bozkır sınırlarının tarım uygarlıkları ile kesiştiği yerler, iki tarafın da kültüründe bazı sentezlenmelere yol açmaktadır ki, bu konu sadece arkeolojik verilerden değil, savaş malzemeleri ve taktikleri, bürokrasi dili, kılık-kıyafet vs. konulardan da takip edilebilir.Makale iki ana coğrafya üzerine yoğunlaşmıştır: İlki, Türklerin orijinal malzemelerini meydana getirdiği güney Sibirya ve Moğolistan bölgesi. Bu coğrafyanın yaşam şekli ve inançları, göçerlerin üretmiş oldukları sanat eserlerini doğrudan etkilemiştir. Burada tarım topluluklarının etkisi minimum seviyededir. İkinci coğrafya ise, Gök Türklerin yerleşik (tarım kültürlerle gerek siyasi gerek kültürel ilişkiler kurduğu sınır boyları. Burada iki büyük kültür bulunur ki ilki Ordos üzerinden Çin, diğeri Tengri dağları üzerinden İran.  Bölgelerarası ilişkiler detaylandırıldığında, göçerlerle yerleşiklerin birlikteliği, hayallerimizde canlanan barbar – medeni ikileminin çok çok ötesinde olduğu anlaşılır. Soğdlar Gök Türklerin hamiliğini daima Sasanilere tercih etmişlerdir. Tang ve Gök Türk idarecilerinin akıllı olanları da (Tai Tsung ve Bilge Kağan gibi, savaş ve yağma politikalarından ziyade, sürdürülebilir ticari ve kültürel ilişkileri temellendirmeye çalışmışlardır. Tespit edilen bölgelerin iyi analiz edilmesi gerekiyor ancak üçünün birden (izole olarak adlandırdığımız Altay dağları çevresi; geçiş bölgeleri olarak ifade ettiğimiz Tengri dağları ile Ordos aynı makale de incelenmesinin, çalışmanın boyutlarını ve anlaşılabilirliğini aşacağını düşündük. Bu yüzden makalemizi ikiye ayırdık: Elinizdeki çalışma, Moğolistan ve Tengri dağlarının, bir sonraki çalışmamız ise Ordos bölgesinin tarihi

Türk Sözlükbiliminin Problemleri The Problems Of Turkish Lexicography

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Andreas Tietze

2012-12-01

-figures, slang and regional dialects.In the second main topic, when Tietze order the problems whichemerge in lexicography, firstly he deals with the problem ofsubsumpiton. According to him when dictionary writer writes hisdictionary which materials enter or keep out the dictionary is a veryserious problem. For example he should dismiss the meanings, entriesand thousands of items which actually din not exist in Turkish with theinclusion of outdated, suggested but in a short time disappering andprobable materials which come from old culture tradition. Further, the author longly examines the problems of alphabet and spelling and problems of explanation and definition. Yazar Türk Sözlükbiliminin problemlerini; Dilin kendine ait problemler ve sözlükbiliminde ortaya çıkan problemler olmak üzere iki ana başlık altında inceler. Birinci problem üzerinde epeyce geniş durur. Bunu toplam altı alt başlıkta uzun uzun irdeler.Yazar, dilin kendine ait problemlerini incelemeye geçmeden önce uzunca bir giriş yapar. Bu bölümde; sözlük yazarının çalışmasına başlamadan bir dizi prensip kararlarını almak zorunda olduğunu belirtir. Sonra Türkçe terimine açıklamaya girişir ve Türkçenin son 1000 yıldır geçirdiği serüveni kısaca özetler. Bu arada daha sonra uzun uzun işleyeceği sorunlara temas eder. Bütün bunların sözlük yazarının işini güçleştiren problemler olduğunu belirtir.Tietze, önce “dilin adı” konusuna açıklık getirir ve buradaki karmaşaya dikkat çeker. Bundan dolayı sözlük yazarının - hali hazırda dilin adlandırılmasında- çıkmaza girdiğini ve kendisinin bir neticeye ulaşmak zorunda olduğunu söyler. İkinci olarak Türkçeyle tarihsel bağlantısı olan lehçelerin (Çağatay, Azeri, Türkmen vd. cazip sözvarlığının ne olacağıdır? Üçüncü konu ise sözlük yazarının sözlüğünü oluştururken tarihsel olarak ne kadar geri gideceği ve sözlük malzemesinin ne kadar eski olacağıdır. D�

Analysis of the characters in ‘Kürk Mantolu Madonna’ regarding the self-concept

OpenAIRE

Serap Arslan-Akfırat

2012-01-01

The current study is a literature review – qualitative analysis study, through which the social-psychological theories and research findings on ‘self-concept’ are presented and evaluated regarding the characters of Kürk Mantolu Madonna, Sabahattin Ali’s novel. The study is composed of three main parts. In the first part, the social psychological theories and research findings on the structure, processes and the contents of ‘self-concept’ are presented in a systematic manner. In the second par...

SOME ASPECTS OF COGNITIVE- LINGUISTIC INTERPRETATION OF TURKIC LANGUAGE CONCEPT TÜRK DİLİ KAVRAMININ BİLİŞSEL-LENGÜİSTİK AÇIKLANMASI ÜZERİNE

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Kamal ABDULLA

2012-06-01

Full Text Available In the given article cognitive-linguistic interpretation of Turkic language concept was done according to the Turkic world and culture context and to the Turkic language-conversation borrowings used in the Russian language. From this point of view according to the “TurkicSlavistic” notion, Turkic-Russian language relationships were looked through and some language-conversation borrowings from Turkic into Russian were analysed. According to the text and proverb examples from “Taury Kassandra” by Chingiz Aytmatov. Some textual-linguistic and parameological borrowings used in Russian are appreciated as conceptual-linguistic. Türk dili kavramının bilişsel-lengüistik açıklanması, Türk dünyası ve uygarlığı bağlamına ve Rusça’da kullanılan Türkçe dil-konuşma alıntılarına göre yapılmıştır. Bu bakımdan makalede “Türkslavistik” anlayışına göre Türkçe-Rusça ilişkileri bütün olarak ele alınmış ve Türkçeden Rusçaya geçen dil-konuşma alıntıları tahlil edilmiştir. Şöyle ki; C. Aytmatov’un “Tavrı Kassandra” eserinden alınan metin ve atasözü örneklerine göre Rusçada kullanılan metindilbilimsel ve atasözübilimsel nitelikteki bazı alıntılar kavramsal-lengüistik olarak değerlendirilmiştir.

Dental students' evaluation of 2 community-oriented PBL modules.

Science.gov (United States)

Pau, A K; Collinson, S; Croucher, R

1999-11-01

To evaluate dental students' perception of 2 problem-based learning (PBL) modules in Dental Public Health implemented within the context of a traditional formal curriculum. 2 dental community modules were implemented with an 8-month interval between them on the same group of dental undergraduates; the first in Term 2 and the second in Term 4 of a 5-year 15-term dental course. At the end of each module, a semi-structured questionnaire was administered to evaluate the introductory lecture, the fieldwork activity and the organisation of the modules. In both modules, students reported gaining insight into the subject matter, skills in teamwork, making presentations and collecting data. Some students in the 1st module needed more time to fulfil their learning objectives and had difficulty in collecting data. In the 2nd module, students reported that they lacked motivation because of the place of the module within their timetable. Opinions differed about groupwork. The content of and interest generated by fieldwork activity was rated more positively in the 2nd module than the 1st. Less positively rated in the 2nd module was the introductory lecture and module organisation. Implementing PBL within a traditional curriculum does not offer uniform outcomes for students. Optimum group size and adequate time are necessary if students are to benefit from PBL. A consistent and continuous PBL approach should be adopted rather than a sporadic one. Further research should establish the optimum balance between PBL and traditional approaches that would allow students to maximise the benefits of both and to identify those students best equipped to benefit from a 'mixed economy' of learning.

THE NAMES AND MARKINGS GIVEN TO THE HORSES ACCORDING THEIR COAT COLORS IN TURKISH CULTURE TÜRK KÜLTÜRÜNDE DONLARINA GÖRE ATLARA VERİLEN ADLAR VE NİŞANLARI

Directory of Open Access Journals (Sweden)

Salim KÜÇÜK

2009-12-01

Full Text Available One of the richnesses of the Turkish language is the coat colors and markings of the horses. However, it’s not possible to talk about a similarity while giving names to these coat colors and markings in written sources and this makes it difficult to classify them and also the Works of the researchers. In this study it’s aimed to anayze the coat colors and markings in written sources from the beginning to nowadays by categorizing the coat colors first and then determining the main markings. Not only historical Turkish dialects but also contemporary Turkish dialects have been made use of for a perfect determination of the coat colors and markings to show their historical developments. In the study, it is noticed that horse coat colors and markings have been taken place more in the written works of the Middle Age Turkish rather than the age of Ancient Turkish. Especially Divanü Lûgati’t-Türk is a rich literary work on this subject. The two other dictionaries named Derleme and Tarama in contemporary Turkish are also richer than the ones used in Karahanli period. Turkish used in Turkey today differentiates from both its historical dialects and up-to-date dialects with this aspect. Türkçenin zenginliklerinden biri de at donları ve nişanlarıdır. Ancak yazılı kaynaklarda at donları ve nişanlarının adlandırılmasında tam bir birlikten söz etmek mümkün değildir. Bu durum at donlarının gruplandırılmasını ve araştırmacıların işini güçleştirmektedir. Başlangıçtan günümüze yazılı kaynaklarda yer alan at donları ve nişanlarını incelemeyi amaçlayan bu çalışmada önce at donları gruplandırılmış ardından belli başlı at nişanları tespit edilmiştir. Araştırmada yalnız tarihî Türk lehçeleriyle yetinilmemiş, bazı at donlarının özelliklerini ve tarihi gelişimlerini tam olarak belirleyebilmek için aynı zamanda çağdaş Türk lehçelerinden de yararlanılmıştır.Çalışmada Eski Türk

Cumhuriyet’in İlk Yıllarında Yazılan Tiyatro Eserlerinde Atatürk ve Atatürkçülük An Examination of Atatürk and Kemalism in the Works of Theater in the Early Years of the Republic

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Ertan EROL

2012-09-01

Full Text Available A new move of renovation started with the foundation of the Republic of Turkey after the country was freed from enemy invasion. At that time it was the Western nations who made up the modern worldand owned the cutting edge science and technology. Consequently thenew Turkish republic looked to the Western civilization whichrepresented "the modern". Renovation involved not only the fields ofscience and technology which were deemed as the catalysts ofmodernization but also cultural issues. In the aftermath of thefoundation of the republic modernization was directed toward culturalissues. Various cultural activities were organized in order to make thepublic adopt the new regime through and increase public interest in art.Among these cultural activities production and staging on theaters ofnew plays are remarkable.The aim in this study is to examine the works of theater producedafter the proclamation of the Republic, between 1923-1938 from thepoint of view of Kemalism. In this paper, those theater works whichwere produced between 1923 and 1938 (the year when M.KemalAtatürk passed away are examined. It was observed that the “MaviYıldırım/Blue Lightening” by Aka Gündüz “Gavur İmam/Infidel Imam”by Burhan Cahit, “Destan/Legend” by Galip Naşit, “Kahraman/Hero”and “Akın/Raid” by Faruk Nafiz, “On Yılın Destanı/The Legend of theDecade” by Halit Fahri, “Beş Devir/Five Eras” by Yaşar Nabi,“Bayönder/Mr. Leader” by Münir Hayri, “Oğuz Destanı/Oğuz Legend”by Vehbi Cem Aşkun were produced during the aforementioned period.In this study, the question as to what extend these works oftheater reflect Kemalist thinking and Kemalism with respect to theirthemes, characters and the characteristics is examined. Türk ulusunun düşman işgalinden kurtuluşundan sonra Cumhuriyet’in ilanıyla birlikte yeni bir çağdaşlaşma hamlesi başlamıştır. O dönemin şartları içinde çağdaş dünya ülkeleri arasında yer

Vision for the RWMC Project on 'Preservation of RK and M Across Generations'

International Nuclear Information System (INIS)

2011-01-01

Disposal of long-lived radioactive waste in engineered facilities built in stable, deep geological formations is the reference means for permanently isolating the waste from the biosphere. Although this management method is conceived to be intrinsically safe and final, i.e., not depending on the presence and intervention of man for fulfilling its safety goal, there is no intention to forgo, at any time, knowledge and awareness either of the repository or of the waste that it contains. As repository development is reaching industrial maturity, means are being studied to maintain indirect forms of oversight once the repository is closed including monitoring, applying safeguards according to international agreements, maintaining records, and ultimately maintaining memory. Institutional arrangements need be integral part of those provisions, as continuity of records, knowledge and memory (RK and M) will require, in the first place, identifying a chain of responsibilities. At the same time, novel methods ought also to be studied and applied that are less vulnerable to changes in socio-economic conditions and may be less reliant on institutional presence. Overall, this is a multidisciplinary work area in which much learning is expected over the coming years. In this document a vision for the RWMC project on 'Preservation of RK and M across generations' is described covering the period 2011-2014. The document represents the shared vision of the project members and incorporates the RWMC comments at their latest meeting in March 2011. It is understood that it will be necessary to update this document regularly in the course of the project

Türk Dili ve Edebiyatı İle Türkçe Öğretmeni Adaylarının Dede Korkut Hikâyeleri Hakkındaki Bilgi ve Görüşleri / The Knowledge and Opinions of the Turkish Philology and Turkish Teacher Candidates Regarding Dede Qorqut Stories

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Mustafa Yeniasır

2017-09-01

Full Text Available Abstract Dede Qorqut Stories which is one of the most prominent works of Turkish is a precious work which should be known by every Turkish teenager. Unfortunately, having a low reading rate in our country is a known fact. Therefore, being located in a broadly manner of Dede Qorqut Stories in National Education Curriculum which is situated among the most valuable works of Turkish and thus Turkish Literature, submits an obligation in terms of the students for learning the culture of the society they live in better.  The purpose of the study is to reveal the knowledge and opinions of the Turkish Philology and Turkish teacher candidates being educated in the first grade of the universities regarding Dede Qorqut Stories. In the research, survey has been used as a data collection tool. The survey has been applied to Turkish philology and Turkish teacher candidates who began studying in the first grade of 2015-2016 Fall semester. The findings obtained as a result of the study has been discussed and various suggestions has been made.   Öz Türkçenin en önemli yapıtlarından biri olan Dede Korkut Hikâyeleri, her Türk genci tarafından bilinmesi gereken değerli bir eserdir. Maalesef ülkemizde okuma oranının düşük olduğu bilinen bir gerçektir. Bundan dolayı Türk edebiyatının ve dolayısıyla Türkçenin en değerli eserleri arasında bulunan Dede Korkut Hikâyelerinin Millî Eğitim müfredatında geniş bir şekilde yer alması, öğrencilerin içinde yaşadıkları toplumun kültürünü daha iyi öğrenmeleri açısından zorunluluk arz etmektedir. Bu çalışmanın amacı, üniversite birinci sınıfta öğrenim gören Türk Dili ve Edebiyatı (TDE ile Türkçe öğretmeni adaylarının Dede Korkut Hikâyeleri hakkındaki bilgi ve görüşlerini ortaya koymaktır. Araştırmada veri toplama aracı olarak anket kullanılmıştır. Hazırlanan anket, 2015-2016 Güz döneminde birinci sınıfta öğrenim görmeye başlayan TDE ve Türk

Mediebrud mellem organisationer og netværk Mediebrud mellem organisationer og netværk [Media disruptions between organisations and networks

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Lars Clausen

2010-11-01

Full Text Available Den foreliggende artikel undersøger eliters afhængighed af udbredelsesmedie og kommunikationsmedie inden for den Luhmannske systemteori. Gennem anvendelse af et mediebegreb fra medium-theory og koncepter fra elite-forskningen udfoldes eliters medieafhængighed på tre niveauer; udbredelsesmediet, system-mediet og føring (lederskab. Eliters specifikke kommunikationsform er afhængig af de tre mediers aktuelle beskaffenhed. Hypotesen er, at eliters form er medieafhængig, og at det bliver tydeligt i den aktuelle præsens af netværk i samtiden og i den socialvidenskabelige forskning.The present article examines the elites’ dependence on diffusion media and communication media within the Luhmannian system theory. Through the use of a media concept from medium-theory and concepts from research on elites, three levels of dependency emerge: the diffusion media, the media of the system and leadership as the specific communication medium of elites, which is dependent on the state of the three media. The hypothesis is that the specific form of elites has specific, epochal media dependencies, and this becomes evident in the present in social scientific research.

Atatürk and the History of Foreign Language Education in Turkey

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Gülay SARIÇOBAN

2012-04-01

Full Text Available Background and Problem: There have been various opinions on the policies of foreign language education in our country since the foundation of our republic. There is no doubt that Atatürk placed much more importance in foreign language education than the other nations’ founders on earth. For the purpose of foreign language education, the department of western languages and literatures was established in the faculty of language, history, and geography at Ankara University. This department was also considered to contribute the fields of history and Turkish studies. Foreign language and literature studies are believed to be responsible for establishing interaction and communication between cultures. If a scientific approach to a foreign language and its literature and the knowledge of methodology leads to acquisition of a native language, this means that it performs its real function. Atatürk, believing this contribution of knowing a foreign language to the mother tongue of a nation, absorbs the importance of this fact. He strongly asserted that we should make use of this advantage for our national benefits: by not teaching a topic in a foreign language, but teaching a foreign language. To him, the courses should be conducted in Turkish. However, just contrary to his views, we had courses conducted in the foreign language in Anatolian high schools, science high schools, and/or in private colleges. Thus, the number of these schools has increased and therefore, the importance of mother tongue has lessened even in our country. Purpose: This study aims at discussing the foreign language policies followed in our country by referring to certain periods.Method: For the purpose of the current study, the researchers have gone through literature review process in detail and compiled the data they could reach from various reliable sources.

Modifications and additions to selected TOUGH2 modules

International Nuclear Information System (INIS)

Wu, Y.S.; Mishra, A.K.

1998-01-01

The purpose of this report is to provide all software baseline documents necessary for the software qualification of the revised versions of the selected TOUGH2 modules, which include single-phase gas (EOS1G), effective continuum method (EOS3/ECM), saturated/unsaturated flow (EOS9), and radionuclide transport (T2R3D) modules of the TOUGH2 code. TOUGH2 is a numerical simulation code for multi-dimensional, coupled fluid and heat flow of multiphase, multicomponent fluid mixtures in porous and fractured media. This report augments the document Software Qualification of Selected TOUGH2 modules. This report contains the following sections: (1) requirement specifications and code development and (2) software validation test plan and results. These sections comprise sequential parts of Software Lifecycle, and should be used in conjunction with the TOUGH User's Guide, TOUGH2 documentation, TOUGH2 Software Qualification, and Software Qualification of Selected TOUGH2 modules. The version of TOUGH2 used with the software being qualified herein is the October 1996 Standard Version 1.2, as qualified in Wu et al. (1996) and housed at the Department of Energy's Energy Science and Technology Software Center (ESTSC) in Oak Ridge, Tennessee

Tallinna Moodul = Tallinn Module / Siiri Vallner

Index Scriptorium Estoniae

Vallner, Siiri, 1972-

2004-01-01

Rahvusvahelisest disainivõistlusest Tallinna Moodul, mille eesmärk oli leida tänavamööbli süsteem, kus erinevad elemendid (kioskid, telefoniputkad, istepingid, bussiootepaviljonid, reklaamialused jne.) on seotud kontseptuaalselt ühtseks tervikuks. Osalejatest, võidutöödest. Preemiad: I - Clayton Welham, Martin Yong, London, II - Samson Adjei, Harry Dobbs, Greg Epps, London, III - Carmelo Baglivo, Luca Galofaro, Rooma. Eripreemiad (2)

1826 Tarihli Grek Harfli Türkçe İncil ile 1827 Tarihli Arap Harfli Türkçe İncil'in Çekim Ekleri Bakımından Karşılaştırılması Comparison of the 1826 Turkish Bible in Greek Characters and the 1827 Turkish Bible in Arabic Characters in terms of Inflectional Affixes

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Mustafa KILIÇARSLAN

2013-09-01

different from the Arabic charecters Turkish Bible. İncil hemen hemen tüm dünya dillerine olduğu gibi Türkçeye de tarih boyunca birçok kez çevirisi yapılmış bir kutsal kitaptır. Türkçe İncil tercümelerinin tarihi neredeyse İngilizce, Fransızca ve Almanca İnciller kadar eskidir. Yeni Ahit (Yeni Antlaşma da denilen İncil’in Osmanlı Türkçesine ilk olarak 1662-1665 yıllarında IV. Mehmed’in baştercümanı Ali Bey (Wojciech Bobowski tarafından yapılmış olduğu bilinmektedir. Türkçe İncil tercümelerinin daha sonraki yüzyıllarda ise matbu olarak da yapıldığı görülür. Bunlardan en eskisi Ali Bey’in tercümesine dayalı olarak 1819 tarihinde Paris’te yayımlanmıştır.Osmanlı Devletinde Arap harfli Osmanlı Türkçesi ile yapılmış İncil tercümelerinin yanı sıra daha az bilinen bir de Grek harfli İncil tercümeleri vardır. Bu çalışmada öncelikle çalışmaya esas olan 1826 tarihli Grek harfli Türkçe bir İncil ile 1827 tarihli Arap harfli Türkçe bir İncil’in tanıtımı yapılmıştır. Daha sonra her iki metnin Markos Bölümü Birinci Bab’ının çekim ekleri yönüyle bir karşılaştırılması yapılmıştır. Bu aşamada her iki metinde geçen çekim ekleri karşılaştırılmış, yeteri kadar örnekle konunun ortaya konmasına çalışılmıştır. Çalışmanın en sonunda ise çalışmada kullanılan İncil’in ilgili bölümünün çevirileri ve tıpkıbasımları yer almaktadır.Bazı Grek harfli Türkçe İncil tercümeleri Arap harfli Türkçe İncil tercümelerinin bire bir neşirleridir. Ancak kimi Grek harfli İncil tercümelerinin ağız hususiyetlerinin nispeten daha fazla olduğu ama bunların sentaks bakımından Arap harfli Türkçe İncillerden fazla farklılıklar göstermediği bilinmektedir. Çalışmamıza konu olan 1826 tarihli Grek harfli Türkçe İncil tercümesinin de Karamanlıca ağız özellikleri taşıyan ancak sentaks bakımından Arap harfli Türkçe İncil terc

The development of form two mathematics i-Think module (Mi-T2)

Science.gov (United States)

Yao, Foo Jing; Abdullah, Mohd Faizal Nizam Lee; Tien, Lee Tien

2017-05-01

This study aims to develop a training module i-THINK Mathematics Form Two (Mi-T2) to increase the higher-order thinking skills of students. The Mi-T2 training module was built based on the Sidek Module Development Model (2001). Constructivist learning theory, cognitive learning theory, i-THINK map and higher order thinking skills were the building blocks of the module development. In this study, researcher determined the validity and reliability of Mi-T2 module. The design being used in this study was descriptive study. To determine the needs of Mi-T2 module, questionnaires and literature review were used to collect data. When the need of the module was determined, the module was built and a pilot study was conducted to test the reliability of the Mi-T2 module. The pilot study was conducted at a secondary school in North Kinta, Perak. A Form Two class was selected to be the sample study through clustered random sampling. The pilot study was conducted for two months and one topic had been studied. The Mi-T2 module was evaluated by five expert panels to determine the content validity of the module. The instruments being used in the study were questionnaires about the necessity of the Mi-T2 module for guidance, questionnaires about the validity of the module and questionnaires concerning the reliability of the module. Statistical analysis was conducted to determine the validity and reliability coefficients of the Mi-T2 module. The content validity of Mi-T2 module was determined by Cohen's Kappa's (1968) agreement coefficient and the reliability of Mi-T2 module was determined by Cronbach Alpha's value scale. The content validity of Mi-T2 module was 0.89 and the Cronbach Alpha's value of Mi-T2 module was 0.911.

Inimesed ostavad ettevõtet, alles seejärel toodet : globaalsete ettevõtete 2012. aasta eesmärk on terviklik imago / Vootele Päi

Index Scriptorium Estoniae

Päi, Vootele, 1988-

2012-01-01

Mainekujundus-konsultatsioonifirma Reputation Institute uuringust "Global RepTrak 100", mille eesmärk oli sõeluda välja kõige parema reputatsiooniga suurettevõtted nii tavatarbija kui ka koostööpartnerite silmis

Webquest (Web macerası öğrenme yönteminin Türkçe dersindeki akademik başarı ve tutuma etkisi / Effect of WebQuest learning method on academic success and attitude in Turkish lessons

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Abdullah ŞAHİN

2012-12-01

Full Text Available ÖZETAraştırmanın amacı, Web Macerası öğretim yönteminin 6.sınıf öğrencilerinin Türkçe dersi akademik başarı düzeylerinde ve Türkçe dersine yönelik tutumlarında bir etkiye sahip olup olmadığını incelemektir. Araştırma, 2008-2009 öğretim yılında Erzurum il merkezinde bulunan Şair Nef’i İlköğretim Okulunda öğrenim gören 20 deney grubunda, 20 kontrol grubunda olmak üzere toplam 40 öğrenci üzerinde gerçekleştirilmiştir. Araştırma ön test- son test kontrol gruplu deneysel desende tasarlanmıştır. Araştırmada biri deney diğeri kontrol grubu olmak üzere toplam iki grup yer almaktadır. Araştırmada veri toplama aracı olarak araştırmacı tarafından geliştirilen ve 6. sınıf öğrencilerinin Türkçe dersi akademik başarı düzeylerini belirlemeyi amaçlayan “Türkçe Dersi Başarı Testi”, Acat (2000 tarafından geliştirilen öğrencilerin Türkçe dersine yönelik tutumlarını belirlemeyi amaçlayan “Türkçe Dersine İlişkin Tutum Ölçeği” ve grupların denkleştirilmesinde kullanılan ve araştırmacı tarafından oluşturulan “Kişisel Bilgi Formu” kullanılmıştır. Araştırma sonunda Web Macerası öğretim yönteminin 6. sınıf öğrencilerinin Türkçe dersine ilişkin akademik başarı düzeylerini ve Türkçe dersine yönelik tutumlarını yükseltmede etkili olduğu sonucuna ulaşılmıştır.

THE SEYFETTIN ÖZEGE RARE WORKS COLLECTION OF ATATÜRK UNIVERSITY LIBRARY / ATATÜRK ÜNIVERSITESI KÜTÜPHANESI SEYFETTIN ÖZEGE NADIR ESERLER DERMESI

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Dr. Coşkun POLAT

2008-09-01

Full Text Available Written works reflecting to one nation’s own culture, custom,way of science understanding, literature and taste of art are theprominent elements that constitute and perpetuate it’s own identity.One of the most important tasks of nations is to make these culturalheritages accessible and utilizable both in today and in future.Seyfettin Özege Collection made up of Turkish Works writtenin old letters in between 1728 and 1928 is one of this kind of heritage.These Works donated to Atatürk University Library are veryimportant for both Turkey and states that were sphere of influence ofOttoman Empire.Main aim of this study is to give information about state ofthis Collection of which awareness and usability is very low. Inaddition to this, there are suggestions about what should be done toincrease the usability of this Collection by both Turkish and foreignresearchers.

TARIHI TÜRK BAHÇELERINDE HAVUZ YAPILARI

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Hilal Turgut

2012-09-01

Full Text Available Hızla değişen ve kalıcı olmayan bahçe tasarımları göçebe hayattan yerleşik hayata geçen Türk toplumunun değişim süreci için önemli ipuçları verebilirdi. Ancak değerlendirme yapılabilecek bahçe örnekleri çok az bulunmakta ve olanların da değişime uğrayıp uğramadıkları net olarak bilinmemektedir. Bu çalışmada; farklı sanat akımları ile tanışmış olan, çoğunun varlığını ancak kitaplardan bildiğimiz tarihi Türk Bahçelerinin havuz detaylarının incelenerek Türk bahçe kültürü hakkında bilgi edinilmesi amaçlanmıştır. Çalışmada, ağırlıklı olarak son tanık olan Sedad Hakkı Eldem’in kaynakları Türk dünyasının önemli sanat kollarından olan tarihi belge niteliği taşıyan minyatürler, gezgin notları, çeşitli rehber nitelikli kaynaklar incelenmiştir. Çalışmada minyatürlerin tercih edilme sebebi, minyatürlerin ince ayrıntıların gösterildiği resimler olmasının yanı sıra Türk resminden önce minyatür sanat örneklerinin var olması ve arşiv niteliğinde çalışmalar olarak değerlendirilebilmesidir. Minyatürde görünümden çok fikir ve gerçeklik ön plandadır. Çalışmanın sonucunda bundan sonra yapılacak Türk Bahçesi çalışmaları için daha detaylı bir bakış açısı ortaya konulması umut edilmektedir. The Pool Structures in Historical Turkish Gardens The fast changes and non-permanent designs in Historical Turkish gardening could have given us important hints about the process of how nomadic Turkish people transformed into the settled life. But there are few samples of these designs to know if they underwent any changes. This study aims at giving information about the pool structures in the historical Turkish gardens, which are closely related to the Turkish culture. In doing so, the study examines the works of Sedad Hakki Eldem, together with miniatures, travel notes and various guiding notes. The reason why miniatures are chosen is

A major QTL corresponding to the Rk locus for resistance to root-knot nematodes in cowpea (Vigna unguiculata L. Walp.).

Science.gov (United States)

Huynh, Bao-Lam; Matthews, William C; Ehlers, Jeffrey D; Lucas, Mitchell R; Santos, Jansen R P; Ndeve, Arsenio; Close, Timothy J; Roberts, Philip A

2016-01-01

Genome resolution of a major QTL associated with the Rk locus in cowpea for resistance to root-knot nematodes has significance for plant breeding programs and R gene characterization. Cowpea (Vigna unguiculata L. Walp.) is a susceptible host of root-knot nematodes (Meloidogyne spp.) (RKN), major plant-parasitic pests in global agriculture. To date, breeding for host resistance in cowpea has relied on phenotypic selection which requires time-consuming and expensive controlled infection assays. To facilitate marker-based selection, we aimed to identify and map quantitative trait loci (QTL) conferring the resistance trait. One recombinant inbred line (RIL) and two F2:3 populations, each derived from a cross between a susceptible and a resistant parent, were genotyped with genome-wide single nucleotide polymorphism (SNP) markers. The populations were screened in the field for root-galling symptoms and/or under growth-chamber conditions for nematode reproduction levels using M. incognita and M. javanica biotypes. One major QTL was mapped consistently on linkage group VuLG11 of each population. By genotyping additional cowpea lines and near-isogenic lines derived from conventional backcrossing, we confirmed that the detected QTL co-localized with the genome region associated with the Rk locus for RKN resistance that has been used in conventional breeding for many decades. This chromosomal location defined with flanking markers will be a valuable target in marker-assisted breeding and for positional cloning of genes controlling RKN resistance.

1911-1918 Yılları Arasında Türk Yurdu Dergisine Konu Olan Bazı Tartışma ve Polemikler / Some Polemics and Discussions which were Subjected In Turk Yurdu Magazine Between 1911-1918

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Ümmet Erkan

2016-01-01

Bazı Tartışma ve Polemikler  Öz Türk Yurdu Dergisi 1911 yılında yayın hayatına başlamış, Türk milliyetçiliinin en uzun soluklu yayın organıdır. Rusya Türklerinin öncülük ettiği dergide Türklüğün her alanda yükselmesi amaçlanmıştır. Bu makalede Türk Yurdu dergisinin 1911-1918 yılları arasındaki sayılarından yola çıkılarak dergideki bazı kalem tartışmaları, mektuplar ve onlara verilen cevaplar incelenecektir. Bu kalem tartışmalarında Türkçenin sadeleştirilmesinden ne anlaşılması gerektiği ve sınırları, eğitimde ideal eksikliği, eğitim dilinin Türkçe olması ve azınlık okullarının Osmanlı sosyal bünyesine verdiği zararlar, Tanzimatçı reform programının başarılı olup olmadığı ve nedenleri, milli kimliğin dini aidiyete zarar verip vermeyeceği konuları ele alınacaktır. Türk Yurdu dergisi yazarları ile dönemin diğer önemli entelektüellerinin çeşitli gazete ve dergilerde dâhil olduğu bu kalem tartışmaları zengin bir muhteva kazanmıştır. Bu tartışmalar dönemin entelektüel fikir hareketleri ve siyasi akımlar hakkında önemli bilgiler içermektedir. Bu araştırma, yapılan tartışma ve polemiklerin hangi konular etrafında yoğunlaştığını ve Türk Yurdu dergisinin bu tartışma ve polemiklerde ne tür bir yöntem izlediğini ortaya koymaktadır.

Reconsideration of r/K Selection Theory Using Stochastic Control Theory and Nonlinear Structured Population Models.

Science.gov (United States)

Oizumi, Ryo; Kuniya, Toshikazu; Enatsu, Yoichi

2016-01-01

Despite the fact that density effects and individual differences in life history are considered to be important for evolution, these factors lead to several difficulties in understanding the evolution of life history, especially when population sizes reach the carrying capacity. r/K selection theory explains what types of life strategies evolve in the presence of density effects and individual differences. However, the relationship between the life schedules of individuals and population size is still unclear, even if the theory can classify life strategies appropriately. To address this issue, we propose a few equations on adaptive life strategies in r/K selection where density effects are absent or present. The equations detail not only the adaptive life history but also the population dynamics. Furthermore, the equations can incorporate temporal individual differences, which are referred to as internal stochasticity. Our framework reveals that maximizing density effects is an evolutionarily stable strategy related to the carrying capacity. A significant consequence of our analysis is that adaptive strategies in both selections maximize an identical function, providing both population growth rate and carrying capacity. We apply our method to an optimal foraging problem in a semelparous species model and demonstrate that the adaptive strategy yields a lower intrinsic growth rate as well as a lower basic reproductive number than those obtained with other strategies. This study proposes that the diversity of life strategies arises due to the effects of density and internal stochasticity.

Reconsideration of r/K Selection Theory Using Stochastic Control Theory and Nonlinear Structured Population Models.

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Ryo Oizumi

Full Text Available Despite the fact that density effects and individual differences in life history are considered to be important for evolution, these factors lead to several difficulties in understanding the evolution of life history, especially when population sizes reach the carrying capacity. r/K selection theory explains what types of life strategies evolve in the presence of density effects and individual differences. However, the relationship between the life schedules of individuals and population size is still unclear, even if the theory can classify life strategies appropriately. To address this issue, we propose a few equations on adaptive life strategies in r/K selection where density effects are absent or present. The equations detail not only the adaptive life history but also the population dynamics. Furthermore, the equations can incorporate temporal individual differences, which are referred to as internal stochasticity. Our framework reveals that maximizing density effects is an evolutionarily stable strategy related to the carrying capacity. A significant consequence of our analysis is that adaptive strategies in both selections maximize an identical function, providing both population growth rate and carrying capacity. We apply our method to an optimal foraging problem in a semelparous species model and demonstrate that the adaptive strategy yields a lower intrinsic growth rate as well as a lower basic reproductive number than those obtained with other strategies. This study proposes that the diversity of life strategies arises due to the effects of density and internal stochasticity.

Modulation-doped β-(Al0.2Ga0.8)2O3/Ga2O3 field-effect transistor

Science.gov (United States)

Krishnamoorthy, Sriram; Xia, Zhanbo; Joishi, Chandan; Zhang, Yuewei; McGlone, Joe; Johnson, Jared; Brenner, Mark; Arehart, Aaron R.; Hwang, Jinwoo; Lodha, Saurabh; Rajan, Siddharth

2017-07-01

Modulation-doped heterostructures are a key enabler for realizing high mobility and better scaling properties for high performance transistors. We report the realization of a modulation-doped two-dimensional electron gas (2DEG) at the β-(Al0.2Ga0.8)2O3/Ga2O3 heterojunction by silicon delta doping. The formation of a 2DEG was confirmed using capacitance voltage measurements. A modulation-doped 2DEG channel was used to realize a modulation-doped field-effect transistor. The demonstration of modulation doping in the β-(Al0.2Ga0.8)2O3/Ga2O3 material system could enable heterojunction devices for high performance electronics.

Kutadgu Bilig ve Divanü Lûgat-it-Türk’e Göre ‘Saç-Sakal’ Kültürü Üzerine About the Culture of Hair-Beard According to Kutadgu Bilig and Divanü Lûgat-it-Türk

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Adem AYDEMİR

2012-09-01

Full Text Available The critical edition of Kutadgu Bilig, which is one of the works of Karahanlı Turkish period, was published by Prof. Dr. Reşit Rahmeti Arat in 1947. The translation of Divanü Lugati’t Türk, which was published by Besim Atalay in 1939/ 1941. In this article, for thispurpose we used the Reşid Rahmeti Arat Besim Atalay publications ofknowledge for wealth.Kutadgu Bilig and Divanü Lugati’t-Türk is very important worksfor Turkısh culture. Therefore, Kutadgu Bilig and Divanü Lugati’t Türkwhich is the first source about the Turkish world’s literature, language,cultural, social situation in the 11th century gives us very important andoriginal knowledge’s for Turcology researching.Written in Karahanlı Turkish by Kâşgarlı Mahmud, the founder ofthe Turkology, Divanü Lugati’t Türk is one of the main guideline workson Turkish language in many directions. This work has an illuminatingsignificance not only for Karahanlı Turkish period but also for precedingand following periods as Kâşgarlı Mahmud enriched his work, which isprimarily a dictionary, with some grammatical elements besidesvocabulary. The Kutadgu Bilig and Divanü Lugati’t Türk which is thesource about the Turkish world’s literature, language, cultural, socialsituation in the eleventh century gives us very important and originalknowledge’s for Turcology researching. But it has not been analyzedwithin the detailed context of culture of hair-beard. Therefore, in thisarticle, investigates of culture of hair-beard of Turkish culture accordingto Kutadgu Bilig and Divanü Lugati’t Türk. This study made by generalscanning model. Therefore, firstly scanning Kutadgu Bilig and DivanüLugati’t Türk line by line, all words, idioms, proverbs, couplets, andwritten-in-verse components reflecting culture of hair-beard of its agehave been indexed and listed in itself. Karahanlı Türkçesi eserlerinden olan Kutadgu Bilig’in karşılaştırmalı metin yayını 1947 y

Türk Lehçeleri Arasında Benzer Kelimelerin Eş Değerlik Durumu On The Equivalence of The Similar Words İn Turkic Languages

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Mustafa UĞURLU

2012-12-01

Full Text Available Today there are a large number of Turkic languages which aroseout of historical and political reasons in the Turkic area (“Turcia”. Agreat amount and portion of the vocabularies is similar (“Homonym;Paronym” to each other, to some extent, at the level of “primarybranch” and to a lesser degree at the level of “Common Turkic.”However, overlapping of similar words in terms of conceptual scope;that is, their “equivalence” is not something inherently associated withsimilarity.In this study, within the context of the samples selected fromTurkic languages, the state of equivalence of the similar words wasinvestigated. As a result, some similar words in the Turkic languagescan be “one-to-one,” or “one-to-many” equivalent. On the other hand,some similar words may not be equivalent.Turkish dialects resemble each other because they derived fromsome source and the societies interacted with each other culturally,economically, and they effected from other societies in terms of religionand policy. From this point of view Turkish is one of the mostprominent languages in the World. Because Turks have been in contactwith various languages with different frequencies in their geography andlife style. For example the Turkish and the Uzbek Turkish are not basedon the same source, but they have been resembled each other due tothe Arabic and Persian words included in these languages. The intenserelationships between Kazan and İstanbul, the two important centralcities, have caused to inclusion a lot of Ottoman Turkish words in to theKazan Turkish. And the Russian words are to some extend the same inTurkish societies which lived under the soviet rule and RussianCzardom. Türk Dünyasında çeşitli sebeplerle ortaya çıkan ve kendilerine mahsus kelime hazineleri olan birçok “lehçe” bulunmaktadır. Türk lehçelerinde kullanılan kelimelerin önemli bir bölümü, “temel lehçe” düzeyinde; bundan daha az bir bölümü de �

Preparing for the future today: The findings of the NEA RK and M initiative for the short term (This period covers several decades and likely more than 100 years. The actual duration will vary across national programmes)

International Nuclear Information System (INIS)

Schroeder, Jantine

2015-01-01

The NEA initiative on Records, Knowledge and Memory (RK and M) across Generations is an initiative that expresses, supports and aims to answer to an evolution in long-term radioactive waste management (RWM) thinking over the past decades. In the earlier days, the vision seems to have been that waste management ends with the closure of disposal sites. Oversight after closure was not an issue that was studied, (tacitly) assuming safe oblivion of geological repositories, or that archives, markers and other similar tools would suffice, e.g. to avoid human intrusion and/or to understand the nature of the underground facility. Today, it is recognised that oversight should take place for as long as practicable. The new vision includes the preservation of information to be used by future generations. In this paper we want to highlight that such a vision shift with regard to the future requires an accompanying shift with regard to present thinking and practices. To this aim, we will outline some of the studies undertaken within the RK and M initiative that substantiate this finding that the future starts today, and offer suggestions to support its concretization. societal oversight as long as practicable, we should acknowledge the fact that RK and M loss takes place rapidly if it is not acted upon in a conscious and ongoing manner that involves various actors and does more than dumping records into archives. The success of RK and M preservation cannot be judged today by whether they will last for one or ten thousand years. Instead, it lies in establishing and maintaining awareness of the need and responsibility for RK and M preservation in the minds of regulators, operators, stakeholders and, especially in the longer term, the local and regional authorities and general public. Therefore, we should not only think about future activities, but act upon the idea that the long term starts today, and that RK and M preservation needs to be prepared for in the present, while the

2D Finite Element Model of a CIGS Module

Energy Technology Data Exchange (ETDEWEB)

Janssen, G.J.M.; Slooff, L.H.; Bende, E.E. [ECN Solar Energy, P.O.Box 1, NL-1755 ZG Petten (Netherlands)

2012-06-15

The performance of thin-film CIGS (Copper indium gallium selenide) modules is often limited due to inhomogeneities in CIGS layers. A 2-dimensional Finite Element Model for CIGS modules is presented that predicts the impact of such inhomogeneities on the module performance. Results are presented of a module with a region of poor diode characteristics. It is concluded that according to this model the effects of poor diodes depend strongly on their location in the module and on their dispersion over the module surface. Due to its generic character the model can also be applied to other series connections of photovoltaic cells.

2D - Finite element model of a CIGS module

Energy Technology Data Exchange (ETDEWEB)

Janssen, G.J.M.; Slooff, L.H.; Bende, E.E. [ECN Solar Energy, Petten (Netherlands)

2012-09-15

The performance of thin-film CIGS modules is often limited due to inhomogeneities in CIGS layers. A 2-dimensional Finite Element Model for CIGS modules is demonstrated that predicts the impact of such inhomogeneities on the module performance. Results are presented of a module with a region of poor diode characteristics. It is concluded that according to this model the effects of poor diodes depend strongly on their location in the module and on their dispersion over the module surface. Due to its generic character the model can also be applied to other series connections of photovoltaic cells.

Final Design of the SLAC P2 Marx Klystron Modulator

Energy Technology Data Exchange (ETDEWEB)

Kemp, M.A.; Benwell, A.; Burkhart, C.; Larsen, R.; MacNair, D.; Nguyen, M.; Olsen, J.; /SLAC

2011-11-08

The SLAC P2 Marx has been under development for two years, and follows on the P1 Marx as an alternative to the baseline klystron modulator for the International Linear Collider. The P2 Marx utilizes a redundant architecture, air-insulation, a control system with abundant diagnostic access, and a novel nested droop correction scheme. This paper is an overview of the design of this modulator. There are several points of emphasis for the P2 Marx design. First, the modulator must be compatible with the ILC two-tunnel design. In this scheme, the modulator and klystron are located within a service tunnel with limited access and available footprint for a modulator. Access to the modulator is only practical from one side. Second, the modulator must have high availability. Robust components are not sufficient alone to achieve availability much higher than 99%. Therefore, redundant architectures are necessary. Third, the modulator must be relatively low cost. Because of the large number of stations in the ILC, the investment needed for the modulator components is significant. High-volume construction techniques which take advantage of an economy of scale must be utilized. Fourth, the modulator must be simple and efficient to maintain. If a modulator does become inoperable, the MTTR must be small. Fifth, even though the present application for the modulator is for the ILC, future accelerators can also take advantage of this development effort. The hardware, software, and concepts developed in this project should be designed such that further development time necessary for other applications is minimal.

Bibliometric Profile of Turkish Journal of Psychology Türk Psikoloji Dergisi'nin Bibliyometrik Profili

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Umut Al

2007-06-01

at the bottom of psychology journals which indexed by the Social Science Citation Index. Türk Psikoloji Dergisi (TPD 1995 yılından beri Social Science Citation Index tarafından dizinlenmektedir. Bu çalışmada Türk Psikoloji Dergisi (TPD ve Türk Psikoloji Dergisi 'ndeki makaleler bibliyometrik özellikleri açısından ele alınmaktadır. Çalışmamızda 1995-2005 yılları arasında yayımlanan 118 makale incelenmektedir. Araştırmamızda yanıt aranmakta olan sorular şunlardır: 1 TPD 'de yayımlanan makaleler psikolojinin hangi alt alanlarında yoğunlaşmaktadır? 2 TPD'nin çok yazarlık durumu nedir? 3 TPD'de yayımlanan makalelerin yazarları hangi kurumlarda çalışmaktadır? 4 TPD 'de yayımlanan yazıların atıf alanlarının özellikleri nelerdir? 5 TPD 'de yayımlanan makalelerde en sık atıf yapılan kaynak türü (dergi, kitap vb. hangisidir? 6 TPD 'de en sık atıf yapılan dergiler hangileridir? 7 TPD'de yayımlanan makalelerde dergilere yapılan atıfların dağılımı Bradford Yasasına uymakta mıdır? 8 TPD'deki makalelerin atıfları ile JCR'deki etki faktörü arasında bir ilişki bulunmakta mıdır? 9 Psikoloji literatürünün yaşlanma hızı nedir? 10 Etki faktörü açısından TPD'nin JCR'deki psikoloji dergileri arasındaki konumu nedir? Yayımlanan makalelerin neredeyse tamamı Türkçe'dir. Dergide makale yayımlayan kişilerin bağlı bulundukları kurumlara göre yapılan değerlendirmede en çok katkının Hacettepe, Ankara ve Orta Doğu Teknik Üniversitelerindeki araştırmacılar tarafından gerçekleştirildiği görülmektedir. TPD 'de yayımlanan makalelerin %57'sine (67 makale atıf dizinleri kapsamında yayımlanan makaleler tarafından hiç atıf yapılmamıştır. TPD 'de 1995-2005 yılları arasında yayımlanan makalelere toplam 135 atıf yapılmıştır. Bu atıfların %34'ü yazarların kendi makalelerine yapmış olduğu atıflardır. Ayrıca TPD'ye yapılan atıfların %41'i yine TPD'de yay

Türk İstihbaratının Tarihsel Gelişimi

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Eray GÖÇ

2013-09-01

Full Text Available Bu çalışmanın amacı, Türk istihbaratının Osmanlı’nın özellikle son dönemlerinden günümüze tarihsel gelişimi hakkında bilgi vermektir. Tarih sahnesinde istihbarat örgütlerinin üstlendikleri rolleri Türk siyasi hayatına etkilerini araştırmış, günümüz toplum yapısının oluşmasında üstlendikleri roller hakkında bilgi vermiştir. Çalışma Osmanlıda hafiye teşkilatı ile başlayıp, İttihat ve Terakki, MAH, JİTEM, ÖHD ve MİT ile devam eden bir silsilenin Anadolu toprakları üzerinden 100 yılı devirmiş etkisine dair bilgiler içermektedir. Kitap, dergi, makale gibi kaynakların yanı sıra konuyla ilgili çeşitli çalışmalar yapmış olan susurluk araştırma komisyonu başkanı Mehmet Elkatmış, AK parti milletvekili Şamil Tayyar ve gazeteci Nasuhi Güngör ile konuyla ilgili yapılan röportaj da çalışmada yer almaktadır. Çalışma bir taraftan da istihbarat örgütlerinin, devlete hukuk çizgisinin dışına çıkma manevrası kazandırdığı sorunsalını irdelemektedir. Devlet, istihbarat örgütleri sayesinde bekası adına hukuk dışılığı ilke edinme gayretine girmiş olabilir mi? Ya da istihbarat örgütleri devlet adına deyip zaman zaman gayri nizami davranışlar sergilemiş midir? Bu sorular irdelenmiştir.

DİVANÜ LÜGATİ’T- TÜRK’TE YER ALAN TÜRK HALK KÜLTÜRÜ ÖGELERİNİN İLKÖĞRETİM 4. VE 5. SINIF SOSYAL BİLGİLER PROGRAMLARINDA İŞLENİŞİ

Directory of Open Access Journals (Sweden)

Namık ÇENCEN

2016-05-01

-ı Lûgati't Türk, which is written by Kasgarlı Mahmut in 1074, is a solid language and culture legacy from XI century Turkish World. With this precious work, Kasgarlı Mahmut had his name in letters of gold on not only Turkish people’s heart but also in history of Turkish language and culture, and that makes him outstanding value in our culture. In preserving Turkish cultural legacy, course programs and books have a large function.In this article, by taking high Turkish cultural elements (food culture, birth, wedding and death customs, games and entertainments into consideration, it is going to be laid emphasis on practice of these elements in Primary Education 4th and 5th grade Social Sciences programs, and by emphasizing general aims and gains of these cultural elements, there is going to be an emphasis on practice and ratio of these in the Program. This study is qualitative and the data is collected from reviewing documents.From 8 units of 4th grade Social Sciences educational program, there are only 2 units that include cultural elements from Divan-ı Lûgati't Türk. From 8 units of 5th grade Social Sciences educational program, there is only one unit that includes cultural elements from Divan-ı Lûgati't Türk. Social Sciences course, which is thought to be helpful to pass on cultural elements: a course that aims to create sensitive individuals with awareness of cultural elements needs to focus more on Turkish Cultural Elements, according to most educator.Keywords: Council of State of Turkish Dictionary, Social Sciences, Education Program, Curriculum, Values, Acquisitions

Progress Report of the Project on Preservation of Records, Knowledge and Memory (RK and M) Across Generations. March 2011-March 2012

International Nuclear Information System (INIS)

2012-01-01

Various NEA member countries are currently developing and constructing deep geological disposal projects for high-level and/or long-lived radioactive waste and spent fuel. These take decades to develop and implement, and the facilities are to operate passively and safely for millennia. Although different countries are in various stages of development with regard to their programmes for final radioactive waste management (RWM), for all countries with nuclear waste the question arises: Which records need to be maintained? For what purpose? Over which timescales? By whom? For whom? What can be done now - from a managerial, technical, legal, regulatory viewpoint - to provide maximum continuity of records, message, and accessibility? How much effort, and of what kind, is it reasonable to invest, now or later? Consideration of these questions led to the launching of the OECD NEA Project on the 'Preservation of Records, Knowledge and Memory (RK and M) across Generations' by the NEA Radioactive Waste Management Committee (RWMC) in March 2011. A Collective Statement and a Vision Document have been prepared and released with RWMC approval. A project web-site has been created http://www.oecdnea. org/rwm/rkm/. As stated in the Vision document, the RK and M project will work towards a 'Menu-driven document that will allow people to identify the elements of a strategic action plan for RK and M preservation'. This document will contain recommendations to countries on useful practices as well as suggested follow-on activities in this field. The release of the 'Menu driven document' is foreseen in 2014. Currently, the project counts representatives from 16 organisations in 12 countries, plus the IAEA, and has the support of the European Commission. Most national organizations provide a financial or in-kind contribution to the running of the project

Disc dislodgment in Björk Shiley mitral valve prosthesis: two successfully operated cases.

Science.gov (United States)

Dubernet, J; Irarrázaval, M J; Urzúa, J; Maturana, G; Morán, S; Lema, G; Asenjo, F; Fajuri, A

1986-02-01

Two patients with Björk Shiley mitral valve replacement had migration and embolization of the occluding disc. One patient suffered migration of the disc a few hours after surgery and the other had a strut fracture with disc translocation six years after the initial operation. Clinical signs in both cases were pulmonary edema, cardiogenic shock, and absence of prosthetic sounds. Both patients were reoperated on an emergency basis, recovering after a complicated postoperative course. They are on functional Class I, 8 and 1 years later, respectively, with their dislodged discs still in the abdominal aorta. The only hope for survival in these patients is emergency reoperation, once the prosthetic mitral valve dysfunction is confirmed.

Rockere og bandemedlemmers kriminelle karrierer og netværk i ungdommen

DEFF Research Database (Denmark)

Klement, Christian; Pedersen, Maria Libak

2013-01-01

rockergruppe eller en bande, da viden om sådanne mønstre kan hjælpe til at forudsige, hvilke unge der fremadrettet er i risiko for at blive involveret. Undersøgelsesmaterialet består af oplysninger om de personer, der er registreret som rockere eller bandemedlemmer i Politiets Efterretningsstøtte Database (PED......Denne rapport omhandler en undersøgelse af rockere og bandemedlemmers kriminelle karriere og kriminelle netværk i ungdomsårene og i den tidligere voksenalder. Formålet med undersøgelsen er at identificere eventuelle mønstre i kriminaliteten hos unge, der senere i livet bliver medlemmer af en......) og af kriminalitetsoplysninger fra Danmarks Statistik. I analyserne af den kriminelle karriere er der gjort brug af matchede kontrolper-soner, således at de personer, der senere bliver medlemmer af en rockergruppe eller en bande, sam-menlignes med andre lovovertrædere, der ligner dem med hensyn til...

Fully reconfigurable 2x2 optical cross-connect using tunable wavelength switching modules

DEFF Research Database (Denmark)

Liu, Fenghai; Zheng, Xueyan; Pedersen, Rune Johan Skullerud

2001-01-01

A modular tunable wavelength switching module is proposed and used to construct 2x2 fully reconfigurable optical cross-connects. Large size optical switch is avoided in the OXC and it is easy to upgrade to more wavelength channels.......A modular tunable wavelength switching module is proposed and used to construct 2x2 fully reconfigurable optical cross-connects. Large size optical switch is avoided in the OXC and it is easy to upgrade to more wavelength channels....

Trigger Timing Module for SVD2 upgrade at Belle

International Nuclear Information System (INIS)

Chang, M.C.; Gao, Z.W.; Guo, Y.N.; Kawasaki, T.; Ueno, K.; Velikzhanin, Y.S.

2003-01-01

We have developed a Trigger Timing Module (TTM2) for the control and readout electronics (CORE) of the upgraded Silicon Vertex Detector (SVD2) for use in the BELLE experiment. Eleven Trigger Timing Modules located at one VME-crate provide timing and strobe signals for the SVD2 CORE electronics and make communication between SVD2 and Global Decision Logic of the BELLE data acquisition system. The main motivation to make a new TTM design is to avoid glitches

Türkçe Etkinliklerine Yönelik Tutum Ölçeği Geliştirilmesi: Geçerlilik ve Güvenirlik Çalışması

Directory of Open Access Journals (Sweden)

Arif ÇERÇİ

2016-10-01

Full Text Available Türkçe eğitiminde etkinlikler önemli yer tutmaktadır. Öğrencilerin etkinliklere karşı olan tutumlarının bilinmesi, Türkçe eğitiminin amaçlarına uygun etkinliklerin geliştirilmesi bakımından oldukça önemlidir. Bu çalışmada ortaokul 6. ve 7. sınıf öğrencilerinin Türkçe dersi etkinliklerini uygulamaya yönelik tutumlarını ölçebilecek nitelikte bir ölçek geliştirmek amaçlanmaktadır. Türkçe etkinlikleri tutum ölçeğinin geliştirilmesinde, 6. ve 7. sınıf öğrencilerinin etkinlikler konusundaki duygu ve düşüncelerinden hareket edilmiştir. Ölçek, 22 maddeden oluşmaktadır ve likert tipindedir. Ölçeğin geçerlik ve güvenirliğine ilişkin çalışmalar, ortaokul 6 ve 7.sınıf öğrencilerinden rastlantısal örnekleme yöntemiyle seçilen 526 öğrenciden derlenen verilerle gerçekleştirilmiştir. Ölçeğin yapı geçerliliği faktör analiziyle belirlenmiştir. Ölçekteki maddelerin faktör yükleri .425 - .719 arasında değer almaktadır. KMO (Kaiser-Meyer-Olkin değeri .962; iç tutarlık katsayı değeri ise .947’dir. Bu sonuçlar ölçeğin geçerlik ve güvenirlik değerlerine sahip olduğunu göstermektedir.

Bilgisayar Destekli Türkçe Tabanlı Medya İçerik Çözümleme Computer Assisted Turkish Based Media Content Analysis

Directory of Open Access Journals (Sweden)

Arıkan, Aykut

2009-10-01

Full Text Available İçerik çözümleme, çözümlenen medya içeriği nesnesine, yani iletişim metnine yönelik, iyitanımlanmış sistematik bir bilgi sorgulama stratejisidir. Araştırma sürecinin ilk aşamalarındanitibaren neyin aranacağının iyi tanımlanmış olması gereklidir. İçerik çözümlemenin kuramsalaçıklamaları kimi zaman uygulamadan farklılık gösterebilir. İçerik çözümlemeye dayalıaraştırmalar ilgili çalışmanın uygun bir temelde gerçekleştirilmesi için lazım olan aşamaları,teknikleri ve süreçleri gerekli kılarken diğer yandan zaman ve işgücünden tasarrufu da gerektirir.Yeditepe Üniversitesi bünyesinde görev yapan bir grup araştırmacı, Türkçe medya içeriği içinbilgisayar destekli bir içerik çözümleme sistemi geliştirme kararına varmışlardır. Geliştirilenproje önerisi, Mayıs 2007’de TÜBİTAK’a 1001 kodlu bilimsel araştırma projesi olarak sunulmuşve 107K209 kodu ile proje olarak destekleme kararı verilmiştir. Projenin amacı, CumhuriyetDönemi Türk Basınının içeriğini çözümleyecek, Türkçe tabanlı bir içerik çözümleme sisteminigeliştirmektir. Bu projeyle geliştirilen Türkçe tabanlı bilgisayar destekli içerik çözümlemesistemiyle, Cumhuriyet Döneminde 1928’den bu yana yeni Türkçe harflerle yayımlanmış olanTürk gazetelerinin içeriklerinin çözümlenmesi için aşılması gereken en önemli altyapı engeliolan Türkçe içeriği çözümleyebilecek bilgisayar destekli sistem ihtiyacı karşılanmıştır. Bu sonuçraporunun amacı, proje hakkında birinci bilimsel bilgi sağlamak ve projenin metodolojik, bilimselve uygulama kaynaklı bulgularını tartışarak ortaya koymaktır. Raporun yapısı bu nedenledaha ziyade betimleyicidir ve tarihsel betimleme, sistem modelleme vb. bilimsel yöntem vetekniklerden yararlanır. İçerik çözümleme, dilbilimsel ve bilgi erişim yöntemleri tartışmanınodağında yer almaktadırlar.Content analysis is a

Low temperature synthesis of Mo2C/W2C superlattices via ultra-thin modulated reactants

International Nuclear Information System (INIS)

Johnson, C.D.; Johnson, D.C.

1996-01-01

The authors report here a synthesis method of preparing carbide superlattices using ultra-thin modulated reactants. Initial investigations into the synthesis of the binary systems, Mo 2 C and W 2 C using ultra-thin modulated reactants revealed that both can be formed at relatively low temperatures (500 and 600 C respectively). DSC and XRD data suggested a two step reaction pathway involving interdiffusion of the initial modulated reactant followed by crystallization of the final product, if the modulation length is on the order of 10 angstrom. This information was used to form Mo 2 C/W 2 C superlattices using the structure of the ultra-thin modulated reactant to control the final superlattice period. Relatively large superlattice modulations were kinetically trapped by having several repeat units of each binary within the total repeat of the initial reactant. DSC and XRD data again are consistent with a two step reaction pathway leading to the formation of carbide superlattices

Biosphere 2 test module experimentation program

Science.gov (United States)

Alling, Abigail; Leigh, Linda S.; Maccallum, Taber; Alvarez-Romo, Norberto

1990-01-01

The Biosphere 2 Test Module is a facility which has the capability to do either short or long term closures: five month closures with plants were conducted. Also conducted were investigations of specific problems, such as trace gas purification by bioregenerative systems by in-putting a fixed concentration of a gas and observing its uptake over time. In other Test Module experiments, the concentration of one gas was changed to observe what effects this has on other gases present or on the system. The science of biospherics which encompasses the study of closed biological systems provides an opening into the future in space as well as in the Earth's biosphere.

X-(2) Modulator With 40-GHz Modulation Utilizing BaTiO3 Photonic Crystal Waveguides

DEFF Research Database (Denmark)

Girouard, Peter David; Chen, Pice; Jeong, Young Kyu

2017-01-01

Future telecommunication and data center networks as well as quantum optical communication systems will require optical modulators with wide bandwidths, large extinction, low operating voltage, and small size. We report the first quantitative demonstration of slow light enhancement of the electro......-optic (EO) coefficient in a.(2) ferroelectric waveguide at microwave modulation frequencies. This is demonstrated in a compact (1 mm) photonic crystal (PC) device with a voltage-length product (V pi . L) of 0.66 V-cm at 10 GHz and measured EO modulation out to 40 GHz. A local enhancement factor of 12...

NOTES ON DIFFERENCE IN ORKHON MONUMENTS READING AND INTERPRETING MADE BY TURCOLOGIST OF TURKISH ORIGIN TÜRK ASILLI TÜRKOLOGLARIN ORHUN YAZITLARINI OKUMA VE YORUMLAMALARINDAKİ FARKLILIKLAR ÜZERİNE NOTLAR

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Mehmet Cihat ÜSTÜN

2010-04-01

Full Text Available This study is related to the Orkhon inscriptions which are the first examples of Turkish language and have an important place in Asian culture. After a period about 1200 years the turcologist worked on, the Orkhon inscriptions were tried to be read and interpreted taking into acount of Göktürk culture, history and lifestyle. Every new component discovered concerning the lifestyle of Göktürk would make the Orkhon inscriptions possible to be read and interpreted in a different way. Approximately 120 yearly assessment process is not finally over. Orkhon inscriptions have preserved its magical and peculiar structure which are open to new proposals and recommendations. 120-year period evaluated in this study are subject to the Orkhon inscriptions on the Turkish citizen who serves turcology reading and interpretation of research proposals are evaluated in comparison. Bu çalışma, Orta Asya Türk kültürü içerisinde mühim bir yer işgal eden ve Türk yazı dilinin ilk vesikaları olan Orhun yazıtları ile ilgilidir. Yaklaşık 1200 yıllık bir süreçten sonra Türkologların üzerinde çalışmalar yaptıkları Orhun yazıtları Göktürk kültürü, tarihi ve yaşam tarzı dikkate alınarak okunmaya ve yorumlanmaya çalışılmıştır. Göktürklerin yaşantısına dair keşfedilen her türlü yeni öğe bu yazıtların farklı okunmasına ve yorumlanmasına imkân tanıyacaktır. Yaklaşık 120 yıllık değerlendirme süreci nihayete ermiş değildir. Orhun yazıtları yeni teklif ve önerilere açık kendine özgü sihirli yapısını günümüzde de muhafaza etmektedir. Bu çalışmada, 120 yıllık süreç içerisinde değerlendirmeye tabi tutulan Orhun yazıtları üzerinde Türk asıllı olup Türkoloji’ye hizmet eden araştırmacıların okuma ve yorumlama teklifleri karşılaştırmalı olarak verilmeye çalışılmıştır.

Abbâsî Dönemi Önemli Türk Komutanlarından Boğa es-Sağîr Boga es-Sagir an Important Turk Commander of Abbasid Period

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Abdullah Mesut AĞIR

2012-09-01

Full Text Available Between the years 232-234/847-945 of Abbasids period, the period was called as “Turkish Influence” era since it was the period when Turks possessed the military power and they were successful in military command. Abbassids, came to the power after the Umayyads and stayed away from the mevali policy especially enabled the Turks to show theirselves in the historical area. In this way Islamic world testified emerging of the dignified commanders whom had loyalty to their masters and religon. It is remarkable that some of them among these commanders gained influence as much as preposessing the caliphate during its weak terms and even setting up their seperate states. As notorious begs such as Afşin, Boğa el-Kebîr, Boğa es-Sagîr, Vasîf, Eşnas, İnak et-Türk; Boga es-Sagir was also very important lord like the others. The main sources agree with that Boga, who was also known as es-Sagir et-Turki, eş-Şerabi, was turkish man. He was called by Arabs as es-Sagir to distinguish himself from his big brother Boga el-Kebir. Boga is turkish word and is coincided to its different spelling such as “buka”, “buga”. In this manuscript, the activities that this commander performed will be studied. Abbâsîler döneminin 232-334/847-945 yılları arası, Türklerin askerî gücü elinde bulundurdukları ve askerî komuta görevlerinde başarılı oldukları bir dönem olmasından dolayı “Türk Nüfuzu” dönemi olarak adlandırılmıştır. Emevilerden sonra iktidara gelen ve seleflerinin takip etmiş olduğu mevali politikasından uzak duran Abbâsilerin bu siyaseti özellikle Türklerin tarih sahnesinde kendilerini göstermelerine imkân tanımıştı. Bu sayede İslâm âlemi kabiliyetleri ve cesaretleri ile maiyetleri altında bulundukları efendilerine, mensubu bulundukları dinlerine ve bağlı oldukları topraklarına hizmet edecek çok değerli Türk komutanların ortaya çıkışına tanıklık etmiştir. Bu komutanların �

Yabancı Dil Olarak Türkçe Öğrenenlerin Duygusal Algı Becerilerinin Değerlendirilmesi / Assessment of Emotional Literacy Levels of Students Learning Turkish as a Foreign Language

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M. Furkan Uzan

2018-03-01

Full Text Available Abstract The aim of this research is to determine the level of emotional literacy skills of learners who learn Turkish as a foreign language and to examine them according to various variables. For this purpose, emotional literacy general and subscale skills levels of the students learning Turkish as a foreign language have been determined. It was investigated whether the emotional literacy skills of the students who learned Turkish as a foreign language showed a statistically significant difference according to the variables of sex, nationality and Turkish Language acquisition level. After this process, students who learned Turkish as a foreign language were interviewed and their views on emotional literacy were taken and interpreted. As a result of the research, it was determined that the general skill levels of emotional literacy of the students who learned Turkish as a foreign language were in the medium level. It has been determined that students who learn Turkish as a foreign language have difficulties in expressing their feelings and understanding the expressed emotions. And also it has been determined that they are weak in terms of vocabulary. It has been achieved that students who learn Turkish as a foreign language thinking emotional literacy skills are necessary for language teaching. Öz Bu araştırmanın amacı, yabancı dil olarak Türkçe öğrenen öğrencilerin duygusal algı (duygusal okuryazarlık becerisi düzeylerinin belirlenmesi ve çeşitli değişkenlere göre incelenmesidir. Bu amaç doğrultusunda, yabancı dil olarak Türkçe öğrenen öğrencilerin duygusal okuryazarlık becerisi genel ve alt boyut beceri düzeyleri belirlenmiş ve bu düzeyler arasında cinsiyet, uyruk ve Türkçe öğrenim seviyesi değişkenlerine göre istatistiksel olarak anlamlı bir farklılığın olup olmadığı incelenmiştir. Bu işlemin ardından yabancı dil olarak Türkçe öğrenen öğrencilerle görüşme yapılmış ve duygusal

Türkçe Öğretmeni Adaylarının Yabancı Kökenli Sözcük Kullanımlarına İlişkin Bir İnceleme A Research on the Use of Foreign Origin Words by Turkish Language Teacher Candidates

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Esra LÜLE MERT

2012-12-01

tothe 46 words of these. Amacı Türkçe öğretmeni adaylarının yazılı anlatımlarında kullandıkları sözcükleri Türkçe ya da yabancı kökenli olmaları bağlamında değerlendirmek olan çalışmanın problem tümcesi “Türkçe öğretmenliği son sınıf öğrencilerinin sözcük kullanımında Türkçe kökenli olanları seçme / seçmeme oranları nedir?” olarak belirlenmiştir. Bu araştırma, üretilmiş bir yapı üzerinde tarama modelinde betimsel bir araştırmadır. Var olan bir durumu, var olduğu hâliyle betimlemeyi amaçlayan bu yaklaşımda, incelenecek sınav kâğıtlarının dilsel bütünlüğü içinde yer alan yabancı kökenli (doğu-batı sözcükler ile Türkçe kökenli sözcükle ele alınmıştır. Tarama modeline dayalı bu çalışmanın veri kaynağı, 2011-2012 eğitim-öğretim yılında İnönü Üniversitesi Eğitim Fakültesi Türkçe Öğretmenliği Programının 4. sınıfında öğrenim gören 1. öğretimden 25 ve 2. öğretimden 25 olmak üzere toplam 50 öğretmen adayının “Tiyatro ve Drama Uygulamaları” dersinin dönem sonu sınav sorularına verdikleri yazılı yanıtlardır. Kâğıtlarda toplam 4 açık uçlu soru yer almaktadır. 50 öğrencinin 4 soruya verdikleri yanıtlar incelenmiştir. Çalışmada, kaynak olarak “TDK Türkçe Sözlük” (TDK 2005 temel alınmıştır. Kâğıtlar, “içerik çözümlemesi” yöntemiyle incelenmiştir. İncelenen 50 sınav kâğıdında 13.130 sözcük belirlenmiştir. Bu sözcüklerin 4000’i terim olarak nitelendirilmiştir. 9130 sözcük Türk Dil Kurumunun (2005 Türkçe Sözlüğüne bağlı kalınarak yabancı kökenli, Türkçe kökenli başlıklarında sınıflandırılmıştır. Bu bağlamda Türkçe öğretmeni adaylarının yazılı anlatımda kullandıkları sözcüklerin % 12’si yabancı kökenli sözcüklerden oluşmuştur. Belirlenen yabancı kökenli sözcüklerin 157’sinin Türkçe karşılığı Türk Dil Kurumunun (2005 Türkçe S�

Biphasically Modulating the Activity of Carboxypeptidase G2 with Ultrasound

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Wanying Ma

2017-07-01

Full Text Available Background/Aims: Carboxypeptidase G2 (CPG2 has been used for cancer prodrug therapy to realize the targeted release of active drugs, but there yet lacks a means to modulate the CPG2 activity. Here ultrasound was used to modulate the CPG2 activity. Methods: The activity of insonated CPG2 was determined, and then underlying biochemical (i.e., monomer, dimer and conformation and ultrasonic (i.e., heat and cavitation mechanisms were explored. Results: Ultrasound (1.0 MHz increased or decreased the enzymatic activity; the activity decreased as zero- or first-order kinetics, depending on the intensity. L1 (10 W/cm2 for 200 s improved the activity via increasing the specific activity. L2 or L3 (20 W/cm2 for 1200 or 3000 s decreased the activity via disassembling the dimer, degrading the monomer, inducing glycosylation, transforming conformation and decreasing the specific activity. An increase or a slight decrease of activity attributable to 10 W/cm2 was reversible, but the activity decrease due to 20 W/cm2 was irreversible. The enzymatic modulation was realized via cavitation. Conclusion: Ultrasound can biphasically modulate the CPG2 activity, and can be employed in the CPG2-prodrug therapy to adjust the release and moles of active drugs.

Potential-induced degradation of Cu(In,Ga)Se2 photovoltaic modules

Science.gov (United States)

Yamaguchi, Seira; Jonai, Sachiko; Hara, Kohjiro; Komaki, Hironori; Shimizu-Kamikawa, Yukiko; Shibata, Hajime; Niki, Shigeru; Kawakami, Yuji; Masuda, Atsushi

2015-08-01

Potential-induced degradation (PID) of Cu(In,Ga)Se2 (CIGS) photovoltaic (PV) modules fabricated from integrated submodules is investigated. PID tests were performed by applying a voltage of -1000 V to connected submodule interconnector ribbons at 85 °C. The normalized energy conversion efficiency of a standard module decreases to 0.2 after the PID test for 14 days. This reveals that CIGS modules suffer PID under this experimental condition. In contrast, a module with non-alkali glass shows no degradation, which implies that the degradation occurs owing to alkali metal ions, e.g., Na+, migrating from the cover glass. The results of dynamic secondary ion mass spectrometry show Na accumulation in the n-ZnO transparent conductive oxide layer of the degraded module. A CIGS PV module with an ionomer (IO) encapsulant instead of a copolymer of ethylene and vinyl acetate shows no degradation. This reveals that the IO encapsulant can prevent PID of CIGS modules. A degraded module can recover from its performance losses by applying +1000 V to connected submodule interconnector ribbons from an Al plate placed on the test module.

Software qualification of selected TOUGH2 modules

International Nuclear Information System (INIS)

Wu, Y.S.; Ahlers, C.F.; Fraser, P.; Simmons, A.; Pruess, K.

1996-10-01

The purpose of this package of reports is to provide all software baseline documents necessary for the software qualification of the single-phase Gas (EOS1G), Effective Continuum Method (ECM), Saturated/Unsaturated Flow (EOS9), and Radionuclide Transport (T2R3D) modules of TOUGH2, a numerical simulation code for multi-dimensional coupled fluid and heat flow of multiphase, multicomponent fluid mixtures in porous and fractured media. This report contains the following sections: (1) Requirements Specification, (2) Design Description, (3) Software Validation Test Plan and Report, (4) Software User Documentation, and (5) Appendices. These sections comprise sequential parts of the Software Life Cycle, and are not intended to stand alone but should be used in conjunction with the TOUGH User's Guide (Pruess, 1987), TOUGH2--A General Purpose Numerical Simulator for Multiphase Fluid and Heat Flow (Pruess, 1991), and the above-referenced TOUGH2 software qualification document. The qualification package is complete with the attached Software Identification Form and executable source code for the single-phase Gas, Effective Continuum method, Saturated/Unsaturated Flow, and Radionuclide Transport modules of TOUGH2

THE EFFECT OF THE ‘WEST’ON THE REPUBLICAN TURKISH DRAMA CUMHURİYET DEVRİ TÜRK TİYATROSUNDA BATI ETKİSİ

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Müzeyyen BUTTANRI

2010-04-01

Full Text Available Arts and artists in the modern Turkish society were very important for Atatürk, who believed that a modern society could only be establihed in the light of science and arts. He also took great interest in music and performing arts. He believed that schooling was a requirement for perforing arts. In 1930 Joseph Marx was invited to İstanbul from Vien for a vocational drama school under Darülbedayi. And Carl Ebert from Germany was invited to İstanbul as an expert for the drama section of the Academy of Music and Performing Arts, established in 1934. For the consevatory the Russian model has been accepted. It has been decided that he state conservatory training system would depend on western models, and it would not be related with traditional ways. The course ‘the history of drama’ would cover only western drama history. The underlying philosophy in the establishment of the school has been determined by these foreign experts. The teaching staff has consisted of people who have studied western art abroad, besides foreign experts, who have taken place among the staff for a long time. Modern Türk toplumunun ancak bilim ve sanatın ışığında kurulabileceğine inanan Atatürk, sanata ve sa¬natçıya büyük değer verdi. Musiki ve temsil sanatları ile de özel olarak ilgilendi. Ona göre bu sanatların okullaştı¬rılması şarttı. 1930’da Darülbedayi’ye bağlı bir Tiyatro Meslek Okulu için Viyana’dan Joseph Marx İstanbul’a davet edilirken, 1934’te kurulan Musiki ve Temsil Aka¬demisi konservatuarının tiyatro bölümü için Almanya’dan uzman olarak Carl Ebert davet edildi. Konservatuar için de Rus yöntemi uygun görüldü. Okulun kuruluşundaki ana düşünceler de yabancı uzmanlar tarafından tespit edildi. Devlet Konservatuarı’nda tam anlamıyla Batı tarzı eğitim yapılacak, geleneksel Türk tiyatrosu ile ilgili öğre¬time kesinlikle yer verilmeyecekti. Tiyatro tarihi dersinde de Batı tiyatrosu tarihi

Türk Millî Arşiv Belgelerinde Millî Kültür Ve Türkler National Culture And Turks In The Documents Of Turkish National Archives

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Hüseyin DOĞRAMACIOĞLU

2013-09-01

Full Text Available There are some documents about the Turkish national culture and literature in archives. These documents stored in archives and there has not been a comprehensive study on it. These documents are written in the Ottoman language and aren’t translated into modern languages, including Turkish language so far. This archive documents about culture and literature were published in the newspaper of Hâkimiyet-i Milliye (National Sovereignty. Turkish history was researched in different articles and the people were informed about Turkish culture when war years also by some researchers. All these studies have resulted in success. And Turkish people who filled with national spirit had won victories constantly. However, there has not been much research on this newspaper so far because of it was published with the Ottoman language. In this work, I want to give introductory information on these documents and would like to draw attention to this archive documentation.Documents related to the Turkish culture and literature of the Ottoman archives are also available. These documents are regularly published in the newspaper of Hakimiyet-i Milliye. Several pictures, stories and literary articles are those documents. Copies of the newspaper of the Turkish culture and literature are important aspects of research. In this article, the paper analyzed some of the literary and cultural articles. Türk millî kültür ve edebiyatı hakkında devlet arşivlerinde bazıbelgeler vardır. Bu belgeler üzerinde bugüne kadar kapsamlı bir çalışmaolmamıştır. Bu belgeler Osmanlı harfleriyle yazılmış ancak günümüzekadar Latin harfli Türkçe de dâhil olmak üzere hiçbir dileaktarılmamıştır. Türk kültürü ve edebiyatı ile ilgili olan bu arşivbelgeleri Hâkimiyet-i Milliye adlı gazetede yayınlanmıştır. Gazetede MillîMücadele yıllarında savaş haberlerinin yanında Türk tarihi ile ilgiliaraştırmalar bazı yazarlar tarafından farklı makalelerde

Earthquake imprints on a lacustrine deltaic system: The Kürk Delta along the East Anatolian Fault (Turkey)

KAUST Repository

Hubert-Ferrari, Auré lia; El-Ouahabi, Meriam; Garcia-Moreno, David; Avsar, Ulas; Altınok, Sevgi; Schmidt, Sabine; Fagel, Nathalie; Ç ağatay, Namık

2017-01-01

Deltas contain sedimentary records that are not only indicative of water-level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures. The Kürk lacustrine delta lies at the south-western extremity of Lake Hazar in eastern Turkey and is adjacent to the seismogenic East Anatolian Fault, which has generated earthquakes of magnitude 7. This study re-evaluates water-level changes and earthquake shaking that have affected the Kürk Delta, combining geophysical data (seismic-reflection profiles and side-scan sonar), remote sensing images, historical data, onland outcrops and offshore coring. The history of water-level changes provides a temporal framework for the depositional record. In addition to the common soft-sediment deformation documented previously, onland outcrops reveal a record of deformation (fracturing, tilt and clastic dykes) linked to large earthquake-induced liquefactions and lateral spreading. The recurrent liquefaction structures can be used to obtain a palaeoseismological record. Five event horizons were identified that could be linked to historical earthquakes occurring in the last 1000 years along the East Anatolian Fault. Sedimentary cores sampling the most recent subaqueous sedimentation revealed the occurrence of another type of earthquake indicator. Based on radionuclide dating (Cs and Pb), two major sedimentary events were attributed to the ad 1874 to 1875 East Anatolian Fault earthquake sequence. Their sedimentological characteristics were determined by X-ray imagery, X-ray diffraction, loss-on-ignition, grain-size distribution and geophysical measurements. The events are interpreted to be hyperpycnal deposits linked to post-seismic sediment reworking of earthquake-triggered landslides.

Earthquake imprints on a lacustrine deltaic system: The Kürk Delta along the East Anatolian Fault (Turkey)

KAUST Repository

Hubert-Ferrari, Aurélia

2017-01-05

Deltas contain sedimentary records that are not only indicative of water-level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures. The Kürk lacustrine delta lies at the south-western extremity of Lake Hazar in eastern Turkey and is adjacent to the seismogenic East Anatolian Fault, which has generated earthquakes of magnitude 7. This study re-evaluates water-level changes and earthquake shaking that have affected the Kürk Delta, combining geophysical data (seismic-reflection profiles and side-scan sonar), remote sensing images, historical data, onland outcrops and offshore coring. The history of water-level changes provides a temporal framework for the depositional record. In addition to the common soft-sediment deformation documented previously, onland outcrops reveal a record of deformation (fracturing, tilt and clastic dykes) linked to large earthquake-induced liquefactions and lateral spreading. The recurrent liquefaction structures can be used to obtain a palaeoseismological record. Five event horizons were identified that could be linked to historical earthquakes occurring in the last 1000 years along the East Anatolian Fault. Sedimentary cores sampling the most recent subaqueous sedimentation revealed the occurrence of another type of earthquake indicator. Based on radionuclide dating (Cs and Pb), two major sedimentary events were attributed to the ad 1874 to 1875 East Anatolian Fault earthquake sequence. Their sedimentological characteristics were determined by X-ray imagery, X-ray diffraction, loss-on-ignition, grain-size distribution and geophysical measurements. The events are interpreted to be hyperpycnal deposits linked to post-seismic sediment reworking of earthquake-triggered landslides.

Wire Bonding on 2S Modules of the Phase-2 CMS Detector

CERN Document Server

AUTHOR|(CDS)2226525; Pooth, Oliver

The LHC will be upgraded to the HL-LHC in the Long Shutdown 3 starting 2024. This upgrade will increase the collision rate and the overall number of colliding particles requiring high precision particle detectors which are able to cope with much higher radiation doses and numbers of particle interactions per bunch crossing. To fulfill these technical requirements the CMS detector will be upgraded in the so-called Phase-2 Upgrade. Among others the silicon tracking system will be completely replaced by a new system providing a higher acceptance, an improved granularity and the feature to include its tracking information into the level-1 trigger. The new outer-tracker will consist of so called 2S modules consisting of two strip sensors and PS modules with a macro-pixel sensor and a strip sensor. The electrical connection between the strip sensors and the front-end electronics is realized by thin aluminum wire bonds. In this thesis the process of wire bonding is introduced and its implementation in the 2S module ...

The Preservation of Records, Knowledge and Memory (RK and M) Across Generations: Scoping the Issue. Workshop Proceedings Issy-les-Moulineaux, France, 11-13 October 2011

International Nuclear Information System (INIS)

Schroeder, Jantine; Gordon-Smith, Helen; Pescatore, Claudio; )

2012-01-01

The Preservation of Records, Knowledge and Memory Across Generations Workshop was held 11-13 October 2011 in Issy-les-Moulineaux, France, as part of the homonymous project under the aegis of the NEA Radioactive Waste Management Committee. There were 33 participants from 9 countries representing national governments, universities, waste management agencies, safety authorities, plus specialists in both the technical and social sciences. Three international organisations were also represented. The overarching goal of the workshop was to scope the field and gain insights that can guide the further development of the RK and M project. The workshop helped to further contextualize and delineate the field, to learn how different practitioners organise and conduct their work in light of different time scales and what they see as crucial issues throughout their efforts, and to investigate the interaction between RK and M and society. One the first day the key RK and M project documents and the results of questionnaires were presented and discussed. An overview of situations of records and memory loss was presented and views on regulatory implications on long-term record keeping were given. The contribution to be made by social sciences was presented. On the second day planning record preservation and knowledge management was discussed, including presentations on archaeology, markers, and a panel discussion on the film 'Into Eternity'. On the final day experience and thoughts the connection between memory and physical records were presented and discussed. In total 24 talks were delivered, each followed by time dedicated for Q and A, and 4 plenary discussions took place. This document provides a synthesis of all the workshop presentations and accounts of discussions that were held

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons.

Science.gov (United States)

Ali, Yousuf O; Bradley, Gillian; Lu, Hui-Chen

2017-03-07

Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) is a key neuronal maintenance factor and provides potent neuroprotection in numerous preclinical models of neurological disorders. NMNAT2 is significantly reduced in Alzheimer's, Huntington's, Parkinson's diseases. Here we developed a Meso Scale Discovery (MSD)-based screening platform to quantify endogenous NMNAT2 in cortical neurons. The high sensitivity and large dynamic range of this NMNAT2-MSD platform allowed us to screen the Sigma LOPAC library consisting of 1280 compounds. This library had a 2.89% hit rate, with 24 NMNAT2 positive and 13 negative modulators identified. Western analysis was conducted to validate and determine the dose-dependency of identified modulators. Caffeine, one identified NMNAT2 positive-modulator, when systemically administered restored NMNAT2 expression in rTg4510 tauopathy mice to normal levels. We confirmed in a cell culture model that four selected positive-modulators exerted NMNAT2-specific neuroprotection against vincristine-induced cell death while four selected NMNAT2 negative modulators reduced neuronal viability in an NMNAT2-dependent manner. Many of the identified NMNAT2 positive modulators are predicted to increase cAMP concentration, suggesting that neuronal NMNAT2 levels are tightly regulated by cAMP signaling. Taken together, our findings indicate that the NMNAT2-MSD platform provides a sensitive phenotypic screen to detect NMNAT2 in neurons.

Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice.

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Ulrich Meinzer

Full Text Available Nucleotide oligomerisation domain 2 (NOD2 is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs in mice. However, little is known about its role during gut infection in vivo. Yersinia pseudotuberculosis is an enteropathogen causing gastroenteritis, adenolymphitis and septicaemia which is able to invade its host through PPs. We investigated the role of Nod2 during Y. pseudotuberculosis infection. Death was delayed in Nod2 deleted and Crohn's disease associated Nod2 mutated mice orogastrically inoculated with Y. pseudotuberculosis. In PPs, the local immune response was characterized by a higher KC level and a more intense infiltration by neutrophils and macrophages. The apoptotic and bacterial cell counts were decreased. Finally, Nod2 deleted mice had a lower systemic bacterial dissemination and less damage of the haematopoeitic organs. This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice.

The contribution of the social sciences to Andra's RK and M preservation program

International Nuclear Information System (INIS)

Aparicio, Luis

2012-01-01

Andra's research in the field of social sciences and humanities (SSH) takes currently place in the context of a Groupement de laboratoires devoted to the general theme 'Trans-generational transfer and long-time scales'. The research focus of the Groupement has been put on practices and specific devices related to the Cigeo project (geological disposal) with a view to the transmission of means and resources to next generations. The aim is thus to continue the trans-disciplinary work they started on reversibility, but by expanding it towards the idea of next generations 'agency'. Within the axe of 'Knowledge and Memory', a framework is currently being derived, consisting of a review of academic literature and a benchmarking study on very long term memory. This work has identified some research fronts for the social sciences and humanities. For instance, in the field of economics, art and landscape, cultural studies, institutions, archives, etc. Nevertheless, a prominent result of the study is that although a lot of work has been conducted by RWM agencies, academic interest in the topic so far remains limited. RK and M management is usually approached according to the logic of demonstration inspired by safety analysis, and makes a distinction between active and passive safety. Various dilemmas concerning the purpose, as well as the content and the supports, intended for RK and M preservation result from this demonstration approach. For example; - What is the main objective, to facilitate or to avoid access (to remember or to forget, in fine, the existence of the repository)? - What should be preserved, information or contextualized knowledge? - Which are the most reliable devices, those intended for the long term or those for the short term, the technical (passive) or the social (active) devices? An alternative 'demonstration' would consist of approaching the memory issue in term of dilemmas. And dilemmas, by definition, cannot be solved. Taking dilemmas seriously and

Pb2+ Modulates Ca2+ Membrane Permeability In Paramecium

Science.gov (United States)

Bernal-Martínez, Juan; Ortega Soto, Arturo

2004-09-01

Intracellular recording experiments in current clamp configuration were done to evaluate whether Pb2+ modulates ionic membrane permeability in the fresh water Paramecium tetraurelia. It was found that Pb2+ triggers in a dose-dependent manner, a burst of spontaneous action potentials followed by a robust and sustained after hyper-polarization. In addition, Pb2+ increased the frequency of firing the spontaneous Ca2+-Action Potential and also, the duration of Ca2+-Action Potential, in a dose and reversibly-dependent manner. These results suggest that Pb2+ increases calcium membrane permeability of Paramecium and probably activates a calcium-dependent-potassium conductance in the ciliate.

β2-adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts.

Science.gov (United States)

Vyas, Falguni S; Nelson, Carl P; Freeman, Fiona; Boocock, David J; Hargreaves, Alan J; Dickenson, John M

2017-10-15

Tissue transglutaminase 2 (TG2) is modulated by protein kinase A (PKA) mediated phosphorylation: however, the precise mechanism(s) of its modulation by G-protein coupled receptors coupled to PKA activation are not fully understood. In the current study we investigated the potential regulation of TG2 activity by the β 2 -adrenoceptor in rat H9c2 cardiomyoblasts. Transglutaminase transamidation activity was assessed using amine-incorporating and protein cross-linking assays. TG2 phosphorylation was determined via immunoprecipitation and Western blotting. The long acting β 2 -adrenoceptor agonist formoterol induced time- and concentration-dependent increases in TG2 transamidation. Increases in TG2 activity were reduced by the TG2 inhibitors Z-DON (Benzyloxycarbonyl-(6-Diazo-5-oxonorleucinyl)-L-valinyl-L-prolinyl-L-leucinmethylester) and R283 ((1,3,dimethyl-2[2-oxo-propyl]thio)imidazole chloride). Responses to formoterol were blocked by pharmacological inhibition of PKA, extracellular signal-regulated kinase 1 and 2 (ERK1/2), or phosphatidylinositol 3-kinase (PI-3K) signalling. Furthermore, the removal of extracellular Ca 2+ also attenuated formoterol-induced TG2 activation. Fluorescence microscopy demonstrated TG2-induced biotin-X-cadaverine incorporation into proteins. Formoterol increased the levels of TG2-associated phosphoserine and phosphothreonine, which were blocked by inhibition of PKA, ERK1/2 or PI-3K signalling. Subsequent proteomic analysis identified known (e.g. lactate dehydrogenase A chain) and novel (e.g. Protein S100-A6) protein substrates for TG2. Taken together, the data obtained suggest that β 2 -adrenoceptor-induced modulation of TG2 represents a novel paradigm in β 2 -adrenoceptor cell signalling, expanding the repertoire of cellular functions responsive to catecholamine stimulation. Copyright © 2017 Elsevier B.V. All rights reserved.

Analýza marketingového prostředí firmy Pekárkův mlýn

OpenAIRE

Dvořáková, Veronika

2014-01-01

This thesis describes the part of the marketing plan of the selected company. The aim of this thesis is to analyze the internal and external environment of the company Pekárkův mlýn and the subsequent setting marketing objectives of the company. The theoretical part defines and analyzes the various steps by which the marketing plans. The practical part describes the chosen company, its goals and mission, carried out an analysis of internal and external environment, which were mentioned in the...

Atatürk'ün Ekonomik Reformları ve Türkiye Ekonomisine Etkileri (1923-2002 = Economic Reforms of Ataturk and Their Effects on Turkish Economy (1923-2002

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Esat ÇELEBİ

2002-01-01

Full Text Available At the end of I. World War, the economy of the Ottoman Empire was at the point of bankruptcy, just as were her educational and social institutes From the very first day of new Turkish Republic, Mustafa Kemal Atatürk, founder of the Turkish Republic launched new economical reforms, along with reshaping the social and educational institutes. The present study focuses in detail on the cited reforms. Moreover, Atatürk's new economical models, and strategies were also presented. Some important economical figures for the years from 1923 to 1938 along with their impact on the Turkish economy for the years 1938-2002, are also given. To comprehand and appreciate the meaning and importance of economical reforms to the country and people, todays, general economical picture, supported with some important data, are presented, emphasising the most recent bottlenecks of the Turkish economy.

Large-area and highly crystalline MoSe2 for optical modulator

Science.gov (United States)

Yin, Jinde; Chen, Hao; Lu, Wei; Liu, Mengli; Li, Irene Ling; Zhang, Min; Zhang, Wenfei; Wang, Jinzhang; Xu, Zihan; Yan, Peiguang; Liu, Wenjun; Ruan, Shuangchen

2017-12-01

Transition metal dichalcogenides (TMDs) have been successfully used as broadband optical modulator materials for pulsed fiber laser systems. However, the nonlinear optical absorptions of exfoliated TMDs are strongly limited by their nanoflakes morphology with uncontrollable lateral size and thickness. In this work, we provide an effective method to fully explore the nonlinear optical properties of MoSe2. Large-area and high quality lattice MoSe2 grown by chemical vapor deposition method was adopted as an optical modulator for the first time. The large-area MoSe2 shows excellent nonlinear optical absorption with a large modulation depth of 21.7% and small saturable intensity of 9.4 MW cm-2. After incorporating the MoSe2 optical modulator into fiber laser cavity as a saturable absorber, a highly stable Q-switching operation with single pulse energy of 224 nJ is achieved. The large-area MoSe2 possessing superior nonlinear optical properties compared to exfoliated nanoflakes affords possibility for the larger-area two-dimensional materials family as high performance optical devices.

XUV pulse effect on signal modulations of harmonic spectra from H2+ and T2+

Science.gov (United States)

Feng, Liqiang; Liu, Hang; Kapteyn, Henry J.; Feng, April Y.

2018-05-01

The effects of signal modulations on the molecular high-order harmonic generations in H2^{+ } and T2+ have been theoretically investigated. It is found that with the introduction of the XUV pulse, due to the absorption of the extra XUV photons in the recombination process, multiplateaus on the harmonic spectra, separated by the XUV photon energy can be found. Moreover, this multiplateau structure is insensitive to the wavelength of the XUV pulse. In shorter pulse duration, the intensities of the multiplateaus from H2+ are higher than those from T2+; while in longer pulse duration, the opposite results can be found. Finally, by changing the delay time of the XUV pulse, the signal modulations (including the amplitude and the frequency modulations) of the multiplateaus can be controlled.

Validation of the excore detector module of PANBOX 2

Energy Technology Data Exchange (ETDEWEB)

Kim, Du Ill; Kang, Jung Kil; Hwang, Sun Tack [Korea Nuclear Fuel Company, Taejon (Korea, Republic of); Kim, Yeong Il [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Finnemann, H; Boer, R [Siemens/KWU N, Erlangen (Germany)

1999-12-31

In the PANBOX 2 system an excore detector module simulating the excore signal responses during a short term transient is implemented in order to simulate the reaction of the flux detector and control system upon rapid power changes as it occurs e. g., in rod drop events. This module has been verified in the past by comparison calculations with the PANBOX 1 system. This report describes additional PANBOX 2 validation calculations which have been compared with experimental data measured at german plant KKG, cycle 1, for a rod drop event. In general, the PANBOX 2 results are in very good agreement with the KKG experiments. Therefore it is concluded that the excore detector model of PANBOX 2 is successfully validated. 6 refs., 11 figs., 2 tabs. (Author)

Validation of the excore detector module of PANBOX 2

Energy Technology Data Exchange (ETDEWEB)

Kim, Du Ill; Kang, Jung Kil; Hwang, Sun Tack [Korea Nuclear Fuel Company, Taejon (Korea, Republic of); Kim, Yeong Il [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Finnemann, H; Boer, R. [Siemens/KWU N, Erlangen (Germany)

1998-12-31

In the PANBOX 2 system an excore detector module simulating the excore signal responses during a short term transient is implemented in order to simulate the reaction of the flux detector and control system upon rapid power changes as it occurs e. g., in rod drop events. This module has been verified in the past by comparison calculations with the PANBOX 1 system. This report describes additional PANBOX 2 validation calculations which have been compared with experimental data measured at german plant KKG, cycle 1, for a rod drop event. In general, the PANBOX 2 results are in very good agreement with the KKG experiments. Therefore it is concluded that the excore detector model of PANBOX 2 is successfully validated. 6 refs., 11 figs., 2 tabs. (Author)

Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes.

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Asen Daskalov

Full Text Available BACKGROUND: Prions are infectious proteins propagating as self-perpetuating amyloid polymers. The [Het-s] prion of Podospora anserina is involved in a cell death process associated with non-self recognition. The prion forming domain (PFD of HET-s adopts a β-solenoid amyloid structure characterized by the two fold repetition of an elementary triangular motif. [Het-s] induces cell death when interacting with HET-S, an allelic variant of HET-s. When templated by [Het-s], HET-S undergoes a trans-conformation, relocates to the cell membrane and induces toxicity. METHODOLOGY/PRINCIPAL FINDINGS: Here, comparing HET-s homologs from different species, we devise a consensus for the HET-s elementary triangular motif. We use this motif to screen genomic databases and find a match to the N-terminus of NWD2, a STAND protein, encoded by the gene immediately adjacent to het-S. STAND proteins are signal transducing ATPases which undergo ligand-induced oligomerisation. Homology modelling predicts that the NWD2 N-terminal region adopts a HET-s-like fold. We propose that upon NWD2 oligomerisation, these N-terminal extensions adopt the β-solenoid fold and template HET-S to adopt the amyloid fold and trigger toxicity. We extend this model to a putative prion, the σ infectious element in Nectria haematococca, because the s locus controlling propagation of σ also encodes a STAND protein and displays analogous features. Comparative genomic analyses indicate evolutionary conservation of these STAND/prion-like gene pairs, identify a number of novel prion candidates and define, in addition to the HET-s PFD motif, two distinct, novel putative PFD-like motifs. CONCLUSIONS/SIGNIFICANCE: We suggest the existence, in the fungal kingdom, of a widespread and evolutionarily conserved mode of signal transduction based on the transmission of an amyloid-fold from a NOD-like STAND receptor protein to an effector protein.

Combined amino acids modulation with H 2 O 2 stress for ...

African Journals Online (AJOL)

Strategies of amino acids addition coupled with H2O2 stresses were developed for glutathione (GSH) overproduction in high cell density (HCD) cultivation of Candida utilis. Based on the fact that glycine shows two functions of promoting cells growth as well as GSH production, precursor amino acids modulations of feeding ...

Single leg separation prevalence among explanted Björk-Shiley prosthetic heart valves.

Science.gov (United States)

Blot, William J; Signorello, Lisa B; Cohen, Sarah S; Ibrahim, Michel A

2007-11-01

Björk-Shiley convexo-concave (BSCC) prosthetic heart valves are believed to have been implanted in over 86,000 patients worldwide. Limited data are available on the prevalence of single leg separations (SLS) of the valves' outlet struts, a potential precursor to complete valve fracture. Data maintained by the manufacturer, including results of examinations for SLS in explanted valves, were merged with available information on the characteristics of the valve. The prevalence of SLS in the examined valves was calculated according to valve angle, size, position, and study. Among 343 examined valves, the overall prevalence of SLS was 8.2%, but this varied significantly by valve size, being three-fold higher among 29+ mm valves than among smaller valves, with statistically non-significantly higher prevalences among mitral than aortic, and among 70 degrees than 60 degrees valves. By applying the size, position and angle-specific SLS prevalences to the worldwide valve distribution, it is estimated that SLS may be present in 6.8% (95% confidence limits 4.1-9.4%) of all BSCC valves. These findings suggest that SLS may affect between 820 and 1,880 of the almost 20,000 BSCC valves among surviving patients worldwide. Such estimates help frame the context for potential patient screenings, should imaging and acoustic techniques to detect SLS become available.

Magnetic excitations in modulated PrNi2Si2

International Nuclear Information System (INIS)

Blanco, J.A.; Nicklow, R.M.; Schmitt, D.

1994-01-01

The magnetic excitations in a single crystal of PrNi 2 Si 2 have been studied by inelastic neutron scattering. Dispersion curves have been followed through the centered tetragonal Brillouin zone. In the paramagnetic phase, at 39 K, the lowest energy magnetic branch exhibits an important dispersion ranging from 1.9 to 3.5 meV, the minimum energy occuring at the wave vector of the ordered phase; from the observed dispersion the inter-ionic isotropic bilinear exchange parameters are deduced. At 4.2 K, in the modulated phase, the same branch presents a dispersion slightly larger, but not significantly different

Arabidopsis thaliana Remorins Interact with SnRK1 and Play a Role in Susceptibility to Beet Curly Top Virus and Beet Severe Curly Top Virus

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Seungmin Son

2014-09-01

Full Text Available Remorins, a family of plant-specific proteins containing a variable N-terminal region and conserved C-terminal domain, play a role in various biotic and abiotic stresses, including host-microbe interactions. However, their functions remain to be completely elucidated, especially for the Arabidopsis thaliana remorin group 4 (AtREM4. To elucidate the role of remorins in Arabidopsis, we first showed that AtREM4s have typical molecular characteristics of the remorins, such as induction by various types of biotic and abiotic stresses, localization in plasma membrane and homo- and hetero-oligomeric interaction. Next, we showed that their loss-of-function mutants displayed reduced susceptibility to geminiviruses, Beet Curly Top Virus and Beet Severe Curly Top Virus, while overexpressors enhanced susceptibility. Moreover, we found that they interacted with SnRK1, which phosphorylated AtREM4.1, and were degraded by the 26S proteasome pathway. These results suggest that AtREM4s may be involved in the SnRK1-mediated signaling pathway and play a role as positive regulators of the cell cycle during geminivirus infection.

Preservation of Records, Knowledge and Memory across Generations (RK and M). Monitoring of Geological Disposal Facilities - Technical and Societal Aspects

International Nuclear Information System (INIS)

2014-01-01

Geological Repository (October 2013)', which is a contribution of an NEA RWMC Working party, the Forum on Stakeholder Confidence (FSC), to the RK and M project. The latter study draws on a questionnaire survey of FSC members in July and August 2012, followed up by structured interviews with a range of involved stakeholders from both national and local levels from seven countries and also comprises a literature review on the subject. This report is structured as follows: Chapter 2 summarizes the reviews of the literature on technical and societal monitoring published in the past decade. Technical monitoring is a key subject in several international radioactive waste disposal programmes and a number of national publications. Chapter 3 reviews the monitoring goals relevant to the entire repository life-cycle and evaluates a few major monitoring projects. The chapter describes the different monitoring aspects in the different life-cycle stages of the geological disposal program and the different monitoring projects. Chapter 4 outlines a logical scheme for developing a monitoring programme. This selection should be flexible enough to accommodate probable later needs for revisions during the repository life-cycle. Chapter 5 identifies and analyses the major challenges involved in technical monitoring which include: data management, material and equipment durability, parameter selection, identification of processes to be monitored, coupling processes, monitoring after repository closure. Chapter 6 presents the results of a questionnaire survey of members of the Forum of Stakeholders Confidence from the NEA (FSC) on expectations of local communities regarding monitoring and RK and M preservation of radioactive waste management (RWM) facilities. Chapter 7 covers the observations and results of the 2013 International Repository Monitoring Conference and workshop (organised within EC MoDeRn project). Chapter 8 identifies the overall lessons learned and the rationale for monitoring

Atatürk ve Güzel Sanatlar

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Nurgün Koç

2012-07-01

Full Text Available Özet Bilindiği üzere Türkiye Cumhuriyeti’nin kurulmasından kısa süre sonra hemen hemen her alanı kapsayan bir reform süreci başlatılmıştır. Bu yenilik hareketleri sosyal, siyasal, ekonomik vb. alanlarda görüldüğü gibi kültürel konularda da karşımıza çıkmaktadır. Atatürk kültürün önemli unsurlarından biri olan güzel sanatlardaki gelişime çok önem vermiş ve teşvik etmiştir. Uygar ülkeler arasına girmenin güzel sanatlar alanındaki başarılara bağlı olduğunu belirtmiştir. Bu yüzden 1936 yılında Devlet Konservatuarı kurulmuş, sahne sanatları, resim, müzik, heykel v.b güzel sanatların her alanında sanatçıların yetişmesi sağlanmıştır. Bu arada geleneksel sanatlara da önem verilmiş fakat Batılılaşma sürecinin hızıyla biraz geri planda kalmışlardır. Ataturk and Fine Arts Abstract As known, soon after Turkish Republic was founded, a reform process covering almost all fields was launched. These reform movements are also seen in cultural issues as well as in social, political and economic fields. Ataturk attached great importance to the development in fine arts which is one of the important elements of the culture and encouraged it. He stated that entering into civilized countries is up to the achievements in the field of fine arts. Therefore, state conservatory was founded in 1936 and artists in all fields of fine arts like performing arts, painting, music, sculpture were raised. Meanwhile, traditional arts were also emphasized, but remained a bit in the background because of fast process of Westernization. Atatürk et Les Beaux-Arts Résumé Comme on le sait, peu de temps après la fondation de la République de Turquie, le processus de réforme a été lancé dans presque tous les domaines. Ces mouvements d’innovation apparaissent dans les domaines culturels ainsi que dans les domaines sociaux, politiques et économiques. Atatürk a aussi accordé une grande importance au d

Broadband modulation of terahertz waves through electrically driven hybrid bowtie antenna-VO2 devices.

Science.gov (United States)

Han, Chunrui; Parrott, Edward P J; Humbert, Georges; Crunteanu, Aurelian; Pickwell-MacPherson, Emma

2017-10-05

Broadband modulation of terahertz (THz) light is experimentally realized through the electrically driven metal-insulator phase transition of vanadium dioxide (VO 2 ) in hybrid metal antenna-VO 2 devices. The devices consist of VO 2 active layers and bowtie antenna arrays, such that the electrically driven phase transition can be realized by applying an external voltage between adjacent metal wires extended to a large area array. The modulation depth of the terahertz light can be initially enhanced by the metal wires on top of VO 2 and then improved through the addition of specific bowties in between the wires. As a result, a terahertz wave with a large beam size (~10 mm) can be modulated within the measurable spectral range (0.3-2.5 THz) with a frequency independent modulation depth as high as 0.9, and the minimum amplitude transmission down to 0.06. Moreover, the electrical switch on/off phase transition depends very much on the size of the VO 2 area, indicating that smaller VO 2 regions lead to higher modulation speeds and lower phase transition voltages. With the capabilities in actively tuning the beam size, modulation depth, modulation bandwidth as well as the modulation speed of THz waves, our study paves the way in implementing multifunctional components for terahertz applications.

Design of a relativistic klystron two-beam accelerator prototype

International Nuclear Information System (INIS)

Westenskow, G.; Caporaso, G.; Chen, Y.

1995-01-01

We are designing an experiment to study physics, engineering, and costing issues of an extended Relativistic Klystron Two-Beam Accelerator (RK-TBA). The experiment is a prototype for an RK-TBA based microwave power source suitable for driving a 1 TeV linear collider. Major components of the experiment include a 2.5-MV, 1.5-kA electron source, a 11.4-GHz modulator, a bunch compressor, and a 8-m extraction section. The extraction section will be comprised of 4 traveling-wave output structures, each generating about 360 MW of rf power. Induction cells will be used in the extraction section to maintain the average beam energy at 5 MeV. Status of the design is presented

R2R-printed inverted OPV modules - towards arbitrary patterned designs

Science.gov (United States)

Välimäki, M.; Apilo, P.; Po, R.; Jansson, E.; Bernardi, A.; Ylikunnari, M.; Vilkman, M.; Corso, G.; Puustinen, J.; Tuominen, J.; Hast, J.

2015-05-01

We describe the fabrication of roll-to-roll (R2R) printed organic photovoltaic (OPV) modules using gravure printing and rotary screen-printing processes. These two-dimensional printing techniques are differentiating factors from coated OPVs enabling the direct patterning of arbitrarily shaped and sized features into visual shapes and, increasing the freedom to connect the cells in modules. The inverted OPV structures comprise five layers that are either printed or patterned in an R2R printing process. We examined the rheological properties of the inks used and their relationship with the printability, the compatibility between the processed inks, and the morphology of the R2R-printed layers. We also evaluate the dimensional accuracy of the printed pattern, which is an important consideration in designing arbitrarily-shaped OPV structures. The photoactive layer and top electrode exhibited excellent cross-dimensional accuracy corresponding to the designed width. The transparent electron transport layer extended 300 µm beyond the designed values, whereas the hole transport layer shrank 100 µm. We also examined the repeatability of the R2R fabrication process when the active area of the module varied from 32.2 cm2 to 96.5 cm2. A thorough layer-by-layer optimization of the R2R printing processes resulted in realization of R2R-printed 96.5 cm2 sized modules with a maximum power conversion efficiency of 2.1% (mean 1.8%) processed with high functionality.

THE COMPARISON OF ALIENATION IN “KÜRK MANTOLU MADONNA” BY SABAHATTİN ALİ AND “HOMO FABER” BY MAX FRISCH

OpenAIRE

İnci Aras

2014-01-01

In this study, we examine Sabahattin Ali’s “Kürk Mantolu Madonna”, one of the most important literary classics of Contemporary Turkish Literature, and Max Frisch’s “Homo Faber”, a famous novel in Contemporary German Literature. The main purpose of this study on these works which belong to Turkish and German cultures is to evaluate the characters related to their social and personal alienation. Therefore we carry out our analysis in line with the similarities and differences between main chara...

47 CFR 2.201 - Emission, modulation, and transmission characteristics.

Science.gov (United States)

2010-10-01

... characteristics. 2.201 Section 2.201 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY..., and transmission characteristics. The following system of designating emission, modulation, and transmission characteristics shall be employed. (a) Emissions are designated according to their classification...

Magic Clusters of MoS2 by Edge S2 Interdimer Spacing Modulation.

Science.gov (United States)

Ryou, Junga; Kim, Yong-Sung

2018-05-17

Edge atomic and electronic structures of S-saturated Mo-edge triangular MoS 2 nanoclusters are investigated using density functional theory calculations. The edge electrons described by the S 2 -p x p x π* (S 2 -Π x ) and Mo-d xy orbitals are found to interplay to pin the S 2 -Π x Fermi wavenumber at k F = 2/5 as the nanocluster size increases, and correspondingly, the ×5 Peierls edge S 2 interdimer spacing modulation is induced. For the particular sizes of N = 5 n - 2 and 5 n, where N is the number of Mo atoms at one edge representing the nanocluster size and n is a positive integer, the effective ×5 interdimer spacing modulation stabilizes the nanoclusters, which are identified here to be the magic S-saturated Mo-edge triangular MoS 2 nanoclusters. With the S 2 -Π x Peierls gap, the MoS 2 nanoclusters become far-edge S 2 -Π x semiconducting and subedge Mo-d xy metallic as N → ∞.

Long-drift calorimeter modules for the Soudan 2 nucleon decay detector

International Nuclear Information System (INIS)

Hoftiezer, J.

1985-01-01

The first full size 5-ton detector modules for the Soudan 2 nucleon decay experiment have been assembled and operated. Modules consist of a hexagonal array of drift tubes and corrugated steel, instrumented to read out three-dimensional track positions and pulse height. These will be assembled to form an isotropic, continuously sensitive, self-triggering detector. Details of the design, construction, operation and performance of the modules are discussed. 7 refs., 10 figs

Serine/threonine phosphatase tapp2cs might be served as an early signal molecule for water stress in wheat

International Nuclear Information System (INIS)

Song, K. H.; Tian, W. L.; Hou, B. Z.; Guo, J. X.; Mei, X. R.; Li, Y. Z.

2015-01-01

Much progress has been made towards understanding the role of serine/threonine phosphatases type 2C (PP2Cs) in abscisic acid (ABA) signaling transduction. However, how the negative regulator, PP2Cs, responds to plant water loss remains unclear. Here, we used a series of relative soil moisture (RSM: 85 percentage (well watered), 65 percentage (moderate stress), 45 percentage (severe stress) potted winter wheat (Triticum aestivum L.) and the detached leaves to detect ABA levels and transcripts of PP2Cs, including PP2C40, PP2C45, PP2C59 and PP2C6 as well as the core downstream signals of ABA, including ABF, SnRK2.4 and SnRK2.5. The results showed that the continual loss of water led to a consistent increase in ABA levels, and that the mRNA expression levels of PP2Cs were dependent on plant water condition. PP2Cs expression could be induced by a slight loss of water, and inhibited under severe loss of water. These results were further confirmed by the transcripts of ABF, SnRK2.4 and SnRK2.5. Furthermore, in slight loss of water, 100 μM exogenous ABA could promote PP2Cs expression; in severe loss of water, it inhibited PP2Cs expression. In conclusion, ABA accumulation is controlled by water condition and the PP2C expression is dependent on plant water condition, suggesting that PP2Cs might be served as an early signal molecule for water stress in wheat. (author)

SH3 Domains Differentially Stimulate Distinct Dynamin I Assembly Modes and G Domain Activity.

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Sai Krishnan

Full Text Available Dynamin I is a highly regulated GTPase enzyme enriched in nerve terminals which mediates vesicle fission during synaptic vesicle endocytosis. One regulatory mechanism involves its interactions with proteins containing Src homology 3 (SH3 domains. At least 30 SH3 domain-containing proteins bind dynamin at its proline-rich domain (PRD. Those that stimulate dynamin activity act by promoting its oligomerisation. We undertook a systematic parallel screening of 13 glutathione-S-transferase (GST-tagged endocytosis-related SH3 domains on dynamin binding, GTPase activity and oligomerisation. No correlation was found between dynamin binding and their potency to stimulate GTPase activity. There was limited correlation between the extent of their ability to stimulate dynamin activity and the level of oligomerisation, indicating an as yet uncharacterised allosteric coupling of the PRD and G domain. We examined the two variants, dynamin Iab and Ibb, which differ in the alternately splice middle domain α2 helix. They responded differently to the panel of SH3s, with the extent of stimulation between the splice variants varying greatly between the SH3s. This study reveals that SH3 binding can act as a heterotropic allosteric regulator of the G domain via the middle domain α2 helix, suggesting an involvement of this helix in communicating the PRD-mediated allostery. This indicates that SH3 binding both stabilises multiple conformations of the tetrameric building block of dynamin, and promotes assembly of dynamin-SH3 complexes with distinct rates of GTP hydrolysis.

Lehçeler Arası Aktarmalarda Yalancı Eş Değerler Sorunu (Türkiye Türkçesi-Özbek Türkçesi-Yeni Uygur Türkçesi Fiil Örneği Challange of False Equıvalance Between Dialects (Verb Sample of Turkey Turkish-Uzbek Turkish-Modern Uighur Turkish

Directory of Open Access Journals (Sweden)

Hanife ALKAN

2012-12-01

Full Text Available The Turkish language has been divided into different dialectsbecause of some historical and political reasons as well as variouslanguage-internal reasons from past to present. While these dialects aresimilar to each other in some ways, they are also different from eachother in some ways. Vocabulary of dialects is noteworthy in this regard.Although some dialects match up substantially with each other in termsof vocabulary, other dialects match up slightly. The most importantfactor in determining this is if dialects are taking place in the samegroup or not.In our country, especially since the mid-90s, acceleration oftranslation activities’ has caused recognition of other dialects’vocabularies. On the other hand these translation activities havebrought with various translation problems too. Translation of falsefriends is at the top of these problems. These false equivalance wordsare used to being trap for transmitters.This study is focused on false equivalance verbs in vocabularies ofUzbek and Modern Uighur Turkish which are taken place in southeasterndialect group; between these dialects and Turkey Turkishwritten language, false equivalance verbs have been identified and hasbeen focused on meaning differences. During this classification, it hasbeen understood that these differences have happened as a result ofvarios meaning matters such as synonymy, homonymy, polysemy. InUzbek and Modern Uighur Turkish it has been seen that meanings ofverbs are similar; but in Turkey Turkish some of these verbs have haddifferent meanings in time, some of them have already come fromdifferent roots and therefore have different meanings. Through thisstudy, it is hoped that it will be useful in translation studies from thesedialects. Türk dili, geçmişten bugüne, çeşitli dil içi nedenlerin yanı sıra, bazı tarihî ve siyasi sebeplerle de birbirinden farklı lehçelere ayrılmıştır. Bu lehçeler bulundukları gruplara göre bazı yönlerden birbirleriyle

Yabancılara Türkçe Öğretiminde Filmlerin Kullanımı (Selvi Boylum Al Yazmalım Filmi Örneği

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Adem İŞCAN

2017-04-01

Full Text Available Yabancı dillerin öğretimi alanında kullanılan filmlerin, hedef dilin kültürünü öğrencilere öğretmedeki etkisi dünya çapında bilinmektedir. Kültür öğretiminin, dili öğrencilerin ilgisine açacağı düşünüldüğünde çalışmanın Türkçenin yabancı dil olarak öğretimi alanındaki önemi anlaşılacaktır. Bu araştırmanın amacı, Türkçenin yabancı dil öğretiminde filmlerin kullanılmasının, öğrencilerin Türk kültürel unsurlarını fark etmesine ortam hazırlama durumunu ölçmektir. Araştırmada betimsel tarama yöntemi kullanılmıştır. Öğrencilerin sorulara verdiği yanıtlar, nitel araştırma yöntemlerinden birisi olan doküman incelemesi ile analiz edilmiştir. Veri toplama sürecinde, literatür taraması sonucu araştırmacının hazırlamış olduğu sorular öğrencilere yöneltilmiştir. Elde edilen veriler, üç uygulama sonucunda analiz edilmiştir. İlk olarak her bir öğrencinin vermiş olduğu yanıtlar tasnif edilmiştir. Daha sonra her uygulama için verilen yanıtlar, Microsoft Office Excel 2013 programına aktarılmış, burada analize tabi tutulmuş ve son olarak da her bir soruya verilen cevaplar için ortaya çıkan sonuçlar yorumlanmıştır. Elde edilen veriler, öğretmen yönlendirmesi sonucunda Türk kültür ögelerinin, filmler kullanılarak, geleneksel olarak tabir edilen yöntemlerden çok daha verimli biçimde öğretilebildiğini göstermiştir. Filmlerin öğrenciler tarafından ilgi ile takip edilmesi, öğrenmedeki verimi arttırmış, görsel olarak sunulan kültürel unsurlar, kuru bilgiden çok daha öteye geçerek kalıcı hâle gelmiştir.

Quercetin modulates activities of Taiwan cobra phospholipase A 2 ...

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 37; Issue 2. Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2. Yi-Ling Chiou Shinne-Ren Lin Wan-Ping Hu Long-Sen Chang. Articles Volume 37 Issue 2 June 2012 pp ...

Te’sîr-İ Tebrîzî’nin Külliyatı Ve Türkçe Şiirleri Te’sir-i Tebrizi’s Treatise And His Turkish Poems

Directory of Open Access Journals (Sweden)

Mehmet Nuri ÇINARCI

2012-12-01

Full Text Available Within its historical development, one of the most prolific regions of Turkish Literature is Iran that was governed almost one thousand year by Turkish dynasties. Although Iran was governed by Turkish dynasties, in view of its history and literary culture, Iran is the centre of works written in Persian language. Though a great number of poets, grown particularly during the reign of Akkoyunlu, Safavids, Avsars, Kacars, composed their poems in Persian language; they also reserved Turkish poems in their anthologies (Divan either in a limited number or composed poems as many as that could form a separate anthology in its own right. The tradition of composing poem in Turkish was not only peculiar to poets but it was also fulfilled by the Ruler and those who belonged to his family. Cihan Shah, the Ruler of Karakoyunlu, came first with the pen name of Hakiki, Shah Ismail writing under the penname of Hatayi, Shah Abbas II whose pen name was Sani and IbrahimMirza who composed his poems under the pen name of Cahi are all inthe position of the followers of this tradition. Furthermore, Turkishpoems are included in a small amount in the divans of Vaiz-i Kazvi andin an amount enough to compose a small divan in the divans of Saib-iTebrizi, both of whom are among the prominent figures of Sebk-i Hindimovement. Te’sir Tebrizi is also one of the poets with a treatise, havinglived in the Safavids’ era and written Turkish kasides for ShahSüleyman the First and for Shah Huseyin. In this study, ouressential aim is to both present information about the life and treatiseof Te’sir Tebrizi and to discuss his Turkish poems written in variousverses. Türk edebiyatının tarihi gelişim süreci içerisinde en çok eser verdiği bölgelerden biri de yaklaşık bin yıl boyunca Türk hanedanları tarafından yönetilen İran’dır. İran’ın tarihsel geçmişi ve edebi kültürü göz önünde bulundurulduğu zaman her ne kadar Türk hanedanlar tarafından y

CK2 activity is modulated by growth rate in Saccharomyces cerevisiae

International Nuclear Information System (INIS)

Tripodi, Farida; Cirulli, Claudia; Reghellin, Veronica; Marin, Oriano; Brambilla, Luca; Schiappelli, Maria Patrizia; Porro, Danilo; Vanoni, Marco; Alberghina, Lilia; Coccetti, Paola

2010-01-01

Research highlights: → CK2 subunits are nuclear both in glucose and in ethanol growing yeast cells. → CK2 activity is modulated in S. cerevisiae. → CK2 activity is higher in conditions supporting higher growth rates. → V max is higher in faster growing cells, while K m is not affected. -- Abstract: CK2 is a highly conserved protein kinase controlling different cellular processes. It shows a higher activity in proliferating mammalian cells, in various types of cancer cell lines and tumors. The findings presented herein provide the first evidence of an in vivo modulation of CK2 activity, dependent on growth rate, in Saccharomyces cerevisiae. In fact, CK2 activity, assayed on nuclear extracts, is shown to increase in exponential growing batch cultures at faster growth rate, while localization of catalytic and regulatory subunits is not nutritionally modulated. Differences in intracellular CK2 activity of glucose- and ethanol-grown cells appear to depend on both increase in molecule number and k cat . Also in chemostat cultures nuclear CK2 activity is higher in faster growing cells providing the first unequivocal demonstration that growth rate itself can affect CK2 activity in a eukaryotic organism.

The concept of oversight, its connection to memory keeping and its relevance for the medium term: The findings of the RK and M initiative

International Nuclear Information System (INIS)

Hotzel, Stephan

2015-01-01

The medium term was introduced as the period of indirect oversight after repository closure, with timescales in the order of a few hundred years. While the importance of intrinsic control or 'passive' safety features in the post-closure phase of a geological repository has been recognised and stressed before, the role of oversight, by providing the capability to reduce or avoid some exposures, has come to the fore only recently. Oversight for the time being generally refers to 'watchful care' and society 'keeping an eye' on the technical system and the actual implementation of plans and decisions. In some regulatory frameworks oversight is indirectly required, for instance when mandating the creation of a land exclusion zone. In other frameworks, oversight is directly required, as illustrated, for instance, by the long-term stewardship concept of the US Environmental Protection Agency. Although sheer memory of the presence of the facility cannot be enough to constitute oversight, oversight and RK and M preservation do go hand in hand. For example, monitoring after repository closure fosters RK and M preservation, and vice versa. The presenter focused on terminology, potential oversight measures, and on roles and responsibilities of different stakeholders

Single mode CO2 laser frequency modulation up to 350 MHz

Science.gov (United States)

Leeb, W. R.; Peruso, C. J.

1977-01-01

Experiments on internal frequency modulation (FM) of a CO2 laser showed no limitation of FM by the linewidth. However, distortions in the form of strong enhancement of sideband amplitude arise for frequencies equal to the cavity resonant frequencies, most pronounced if the modulator is positioned near a cavity mirror.

Five-year results after valve replacement with the Björk-Shiley 70 degrees convexo-concave prosthesis.

Science.gov (United States)

Koldsland, S; Svennevig, J L; Abdelnoor, M; Aas, H; Semb, G

1992-01-01

In the 18 months up to July 1983, 120 Björk-Shiley convexo-concave prostheses with 70 degrees opening angle were implanted in 47 women and 61 men aged 19-78 (mean 58.6) years. The prosthetic valves were aortic in 65 cases, mitral in 23 and both aortic and mitral in 20 cases. Emergency operation was required in ten cases, and concomitant surgery was performed in 43 (39.8%). The early mortality was 5.5%. A follow-up study, comprising 498 patient years, revealed 73.1% 5-year survival. There were three mechanical failures of prosthesis, in one of which re-replacement was successful. Elective prosthesis replacement was performed in four other cases judged to be at high risk of strut fracture.

Kayseri Gazetesi’ne Göre Atatürk Döneminde Kayseri’de Cumhuriyet Bayramı Kutlamaları

OpenAIRE

ŞANAL, Mustafa

2004-01-01

29 Ekim 1923 tarihinde Cumhuriyetin ilan edilmesi ile birlikte her yılın 29 Ekim tarihinde Cumhuriyet Bayramı kutlamaları ülkemizin her kesiminde coşkun törenlerle kutlanmaktadır. Bu çalışmada Atatürk döneminde Kayseri’de (1926, 1931, 1932, 1935, 1936,1937,1938 yıllarında Cumhuriyet Bayramı törenlerinin nasıl yapıldığı ve bu törenlerde hangi programın uygulandığı konusunda bilgi verilmeye çalışılmış, bu amaçla belirtilen tarihler arasında çıkan yerel gazetelere yansıyan bilgilerden birincil k...

Examples of Loss of RK and M and Possible Countermeasures as Received by the Members

International Nuclear Information System (INIS)

Tunbrant, Sofie

2012-01-01

This presentation gave descriptions and analyses of examples of RK and M loss that were provided by the project members. The purpose was to learn lessons from these examples for the case of final disposal of nuclear waste. The examples treated were the following: Hazardous waste from chalk production, Switzerland; Riet waste dump landfill, Switzerland; Sinkhole phenomena along the TGV-line, France; Hanford Radioactive waste disposal, USA; Volgermeer waste dump, the Netherlands; Anthrax outbreak, Sweden; Studsvic interim nuclear storage, Sweden. During the workshop, the example of Love Canal and of Utah mining tailings being used for road works were also mentioned. The following conclusions and lessons were drawn from these examples: - Records are not always sufficient, it is not because they exist that they are also remembered or even used. Moreover unexpected events may occur (e.g., flooding) that may have unforeseen impacts on data and records stored in archives. - To recover or recreate inventory lists of old waste sites may requires great efforts and entail great cost. - Placing the waste far away and unmarked to prevent unintended intrusion, does not work necessarily. Places considered being 'far away' at the time, tend to be exploited when communities and industries evolve and grow. - It is important to establish good communication path between different organizational units. There are examples when data and information are archived/preserved in one part of an organization (authority, company, municipality, etc.) and not available to another part of the same organization that needs the data/information. - In the beginning it is better to preserve too much than too little. Discussions during the workshop showed the importance of dedicated attention to the reasons for RK and M preservation (cf. why question in the collective statement), especially in relation to the fact that final disposal is about passive safety. Societal and ethical reasons should not be

“Citation Style Language” Uygulaması: APA Kaynak Gösterme Biçiminin Türkçeye Adaptasyonu=“Citation Style Language” Application: The Adaptation of APA Style to Turkish Language

OpenAIRE

Kasım Binici

2013-01-01

Bibliyografya yönetim programları, araştırma metinlerin yazımında yazarlara büyük avantajlar sağlamaktadır.Akademik çevrede EndNote, RefWorks, Zotero, Mendeley en popüler yazılımlardır. Türkçe kaynak gösterme kurallarının tanımlı olduğu biçim dosyalarının olmaması nedeniyle araştırma metni yazımında bu programlar işlevsiz kalmaktadır. Bu çalışmada, APA kaynak gösterme biçiminin Türkçeye adaptasyonu sağlanarak CSL uygulaması ile biçim dosyasında kodlar yazılmıştır. Yeni biçim dosyası Zotero...

The rK39 immunochromatic dipstick testing: A study for K39 seroprevalence in dogs and human leishmaniasis patients for possible animal reservoir of cutaneous and visceral leishmaniasis in endemic focus of Satluj river valley of Himachal Pradesh (India

Directory of Open Access Journals (Sweden)

Sharma Nand

2009-01-01

Full Text Available Background: The newly recognized endemic focus of leishmaniasis in Satluj river valley of Himachal Pradesh (India has both localized cutaneous leishmaniasis (LCL and visceral leishmaniasis (VL predominantly caused by Leishmania donovani. Rapid rK39 immunochromatographic dipstick test detects circulating antibodies to recombinant K39 antigen of L. donovani-infantum complex and is highly specific/sensitive in diagnosing symptomatic or asymptomatic infection in humans and dogs. Methods: The sera from two VL patients and 13 LCL patients, and 31 dogs were subjected to rK39 immunochromatographic dipstick testing with an aim to identify possible animal reservoir for leishmaniasis in this endemic focus. Results and Conclusion: The positive rapid rK39 immunochromatographic dipstick test in 100% VL and 31.8% LCL patients, and 6.5% dogs suggests that both VL and LCL in this focus are apparently being caused by L. donovani-infantum and that reservoir infection is perhaps being chiefly maintained in asymptomatic dogs. However, it needs corroborative evidence in the form of in-vitro parasite cultivation and/or PCR studies for confirmation. A more elaborate study is recommended.

Formelle krav (kap.2)

DEFF Research Database (Denmark)

Nørgaard, Britta Kusk

2015-01-01

Et opslagsværk for studerende til støtte for bacheloropgaveskrivning. Klæd dine studerende på til at skrive den store afsluttende opgave. De studerende får med denne bog et gedigent opslagsværk, som giver svar på alle de spørgsmål, det typisk trænger sig på, når bacheloropgaven skal påbegyndes. B...

NPY2-receptor variation modulates iconic memory processes.

Science.gov (United States)

Arning, Larissa; Stock, Ann-Kathrin; Kloster, Eugen; Epplen, Jörg T; Beste, Christian

2014-08-01

Sensory memory systems are modality-specific buffers that comprise information about external stimuli, which represent the earliest stage of information processing. While these systems have been the subject of cognitive neuroscience research for decades, little is known about the neurobiological basis of sensory memory. However, accumulating evidence suggests that the glutamatergic system and systems influencing glutamatergic neural transmission are important. In the current study we examine if functional promoter variations in neuropeptide Y (NPY) and its receptor gene NPY2R affect iconic memory processes using a partial report paradigm. We found that iconic memory decayed much faster in individuals carrying the rare promoter NPY2R G allele which is associated with increased expression of the Y2 receptor. Possibly this effect is due to altered presynaptic inhibition of glutamate release, known to be modulated by Y2 receptors. Altogether, our results provide evidence that the functionally relevant single nucleotide polymorphism (SNP) in the NPY2R promoter gene affect circumscribed processes of early sensory processing, i.e. only the stability of information in sensory memory buffers. This leads us to suggest that especially the stability of information in sensory memory buffers depends on glutamatergic neural transmission and factors modulating glutamatergic turnover. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

One-dimensional contrast modulations in [001] high-resolution reverse images of Bi2Sr2(Cu1-xNdx)Cu2O8+δ ceramics

International Nuclear Information System (INIS)

Onozuka, T.

1993-01-01

The one-dimensional contrast modulation along the b axis of [001] high-resolution reverse images of the compounds Bi 2 Sr 2 (Ca 1-x Nd x )Cu 2 O 8+δ (x=0.05+0.1n; n=1, 2, 6 and 7) is examined closely using the density distribution recorded from a wide area of the negative film by microphotometric densitometry. Three typical short units of the density distribution, of lengths 4.5b 0 , 5b 0 and 4b 0 , characterized by twin peaks or a single maximum peak with subpeaks in the middle of the unit, are discerned. The density distributions of the three units and the contrast modulations of their images are reproduced well by computer simulations, using three structure models modulated with longitudinal displacement waves along the b axis of the metal atoms. The one-dimensional contrast modulation is attributed to sinusoidal changes in the effective scattering amplitudes for the [001] electron beam of the metal-atom chains along the c axis. The results of the simulation are applied to investigation of the (2, 1) 5 and (3, 1) 4 modulation modes in the modulated structure. (orig.)

Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals.

Science.gov (United States)

Lucena, Rafael; Alcaide-Gavilán, Maria; Schubert, Katherine; He, Maybo; Domnauer, Matthew G; Marquer, Catherine; Klose, Christian; Surma, Michal A; Kellogg, Douglas R

2018-01-22

The size of all cells, from bacteria to vertebrates, is proportional to the growth rate set by nutrient availability, but the underlying mechanisms are unknown. Here, we show that nutrients modulate cell size and growth rate via the TORC2 signaling network in budding yeast. An important function of the TORC2 network is to modulate synthesis of ceramide lipids, which play roles in signaling. TORC2-dependent control of ceramide signaling strongly influences both cell size and growth rate. Thus, cells that cannot make ceramides fail to modulate their growth rate or size in response to changes in nutrients. PP2A associated with the Rts1 regulatory subunit (PP2A Rts1 ) is embedded in a feedback loop that controls TORC2 signaling and helps set the level of TORC2 signaling to match nutrient availability. Together, the data suggest a model in which growth rate and cell size are mechanistically linked by ceramide-dependent signals arising from the TORC2 network. Copyright © 2017 Elsevier Ltd. All rights reserved.

Türkçe Öğretmeni Adaylarının Yazma Eğitimi Dersine Yönelik Tutumlarının Değerlendirilmesi Turkish Teachers Attitudes Towards The Evaluation Of Writing Training Course

Directory of Open Access Journals (Sweden)

Dilek CERAN

2013-03-01

ştirilmesi, herhangi bir bilginin, görüşün kalıcılığını sağlamak ve nesiller arasındaki iletişimi kurmak bakımından önemli bir iletişim aracıdır. Yazma becerisi genellikle formel eğitim yoluyla kazandırılan dil becerilerindendir. Dolayısıyla öğrencilere yazma becerisinin kazandırılması, yazmaya yönelik ilgi ve isteklerinin uyandırılmasında temel sorumluluk öğretmenlere özellikle de Türkçe öğretmenlerine düşmektedir. Türkçe öğretmenleri, öğrencilere yazma deneyimleri kazandırmalı, onları yazmaya teşvik etmeli ve sürece etkin katılımlarını sağlamalıdır. Bu sebeple lisans programında Türkçe öğretmenlerinin söz konusu becerisini geliştirilmeye yönelik derslere ihtiyaç vardır. Bu amaçla Eğitim Fakültelerinin Türkçe Eğitimi bölümü üçüncü sınıf programında Yazma Eğitimi dersine yer verilmiştir.Bu çalışmanın amacı, Türkçe öğretmeni adaylarının Yazma Eğitimi dersine yönelik tutumlarını belirlemektir. Türkçe öğretmeni adaylarının Yazma Eğitimi dersine yönelik tutumlarını tespit etmek için 37 maddelik bir tutum ölçeği hazırlanmıştır. Ölçek, 2011-2012 eğitim öğretim yılında Necmettin Erbakan Üniversitesi Ahmet Keleşoğlu Eğitim Fakültesi Türkçe Öğretmenliği Bölümü’nde öğrenim gören 137 üçüncü sınıf öğrencisine uygulanmıştır.Türkçe öğretmeni adaylarının Yazma Eğitimi dersine yönelik tutumları genel itibariyle olumludur. Ayrıca ölçekten elde edilen bulgular; cinsiyet, öğrenim türü ve ders başarı notlarına göre değerlendirilmiştir.Araştırma sonuçlarına göre, Türkçe öğretmeni adaylarının Yazma Eğitimi dersine yönelik tutumları cinsiyete ve ders başarı notuna göre anlamlı bir farklılık göstermiştir. Kız öğretmen adaylarının derse karşı tutumları erkek öğretmen adaylarına göre daha olumludur. Ders başarı notuna bakıldığında ise ders başarı notu iyi olan öğrenciler, orta ve ge

Isotopic separation of carbon by dissociation of CF2HCl irradiated by a Q-modulated CO2 laser

International Nuclear Information System (INIS)

Ezubchenko, A.N.; Ilyukhin, A.I.; Karchevskii, A.I.; Krasnikov, N.S.; Merzylakov, A.V.; Soloukhin, A.B.

1993-01-01

Isotopic separation of carbon by selective dissociation of CF 2 HCl by radiation from a CO 2 laser with mechanical Q-modulation has been studied experimentally. The modulation frequency was 10 4 sec -1 with a 20 W output. The peak radiation intensity is increased by a factor of 20-100 when modulated, while the average power is 0.5-0.9 that of the laser when operating in continuous mode. The authors show that under these conditions, a separation coefficient on the order of 40-50 is achieved as well as a high degree of the target isotope extraction (70%)

[Strut fracture of a convex-concave 60 degree Björk-Shiley mitral valve prosthesis 5 years after implantation--metallurgic analysis of the prosthesis strut].

Science.gov (United States)

Lemke, B; Rathmann, J; Wiebe, V; Witzel, U

1991-08-01

Acute mechanical failure of prosthetic heart valves is rare, but associated with high mortality when occurring. For convexo-concave Björk-Shiley prostheses only fractures of the outlet strut are reported. We present a case of lethal mechanical complication 5 years after implantation. By additional metallurgic analysis we were able to identify a sequential course of the outlet strut fracture. This could lead to new approaches for early detection of this complication.

Türkiye Türkçesindeki Alıntı Sözcüklerde Görülen Ses Olayları Üzerine Bir İnceleme An Analysis On Phonetic Occurrences Which Of Loaned Words In Turkey Turkish

Directory of Open Access Journals (Sweden)

Veysel İbrahim KARACA

2012-12-01

Full Text Available A society can not live without making contact with other communities. Every community must interact with each other except the non-primitive societies which have been isolated from the world. It is inevitable for languages of communities that have cultural,commercial and social connection not to effect one another.This interaction, taken place from upper culture to sub-culture,producer to consumer, provides the exchange of words through theloaned words. These loaned words as outcomes of communication andmodernity, exist more or less in every languages.Turkish is a language have an interaction with various languagesthrough its history. As in every language, socially, economically,diplomatically and culturally had an interaction, in Turksih also, thereare loaned words from the first written texts to today.In this study, we undertake phonetic occurrences of loaned wordsin Turkish. This study is an synchronic work, based on 10th edition ofTürkçe Sözlük (Türkish Dictionary published by Türk Dil Kurumu (TheInstitution of Turkish Language. The total loaned words which arebelonged to east languages (Arabic, Chines, Ermenian, Iranian,Georgian, Indian, Hebrew, Japanese, Malaysian, Mongolian, Russian,Sudgish, Tibetan and compose the scope of the study, is 8.991. Thedetermination of source of the loaned words are done based on theinformation in Türkçe Sözlük. Our study, limited geographically oneastern languages, is an analyze on %58.63 of total loaned words. Bir toplumun diğer toplumlarla herhangi bir ilişki kurmadan yaşaması mümkün değildir. Dünyadan izole olmuş ilkel toplumlar dışındaki her toplum birbiriyle etkileşimde bulunmak zorundadır. Siyasi, ticari, kültürel ve sosyal ilişkilerle birbirini tanıyan toplumların dillerinin de belli bir ölçüde birbirini etkilemesi kaçınılmazdır.Üst kültürden alt kültüre, üretenden tüketene doğru bir yol izleyen bu etkileşim alıntı sözcükler yoluyla sözcük alış veri

Complete Transversal Disc Fracture in a Björk-Shiley Delrin Mitral Valve Prosthesis 43 Years After Implantation.

Science.gov (United States)

González-Santos, Jose María; Arnáiz-García, María Elena; Dalmau-Sorlí, María José; Sastre-Rincón, Jose Alfonso; Hernández-Hernández, Jesús; Pérez-Losada, María Elena; Sagredo-Meneses, Víctor; López-Rodríguez, Javier

2016-10-01

A patient who underwent previous implantation of a mitral valve replacement with a Björk-Shiley Delrin (BSD) mitral valve prosthesis during infancy was admitted to our institution 43 years later after an episode of syncope and cardiac arrest. Under extreme hemodynamic instability, a mitral valve prosthetic dysfunction causing massive mitral regurgitation was identified. The patient underwent an emergent cardiac operation, and a complete disc fracture with partial disc migration was found. Exceptional cases of mechanical prosthetic heart valve fracture exist. We report the first case of complete transversal disc rupture of a BSD mitral valve prosthesis after the longest period of implantation ever reported in that position. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

HOLDİNGLEŞME EKSENİNDE TÜRK MEDYASINDA TEKELLEŞME SORUNU - THE MONOPOLIZATION PROBLEM IN TURKISH MEDIA ON THE AXIS OF CONGLOMERATE

Directory of Open Access Journals (Sweden)

Barış BULUNMAZ

2012-11-01

Full Text Available Özet:Basın işletmeleri günümüz ekonomik koşullarıiçerisinde, mevcudiyetlerini sürdürebilmek ve faaliyetlerinedevam edebilmek için finansal açıdan güçlü bir yapıya sahipolmak zorundadırlar. Finansal anlamda güçlü bir yapıyasahip olmanın en önemli şartlarından biri de, basınişletmelerinin gelir kalemleri ile gider kalemleri arasında,pozitif anlamda bir artış sağlamalarıdır. Ancak, gerek basınsektörü içerisindeki rekabet şartlarının zorluğu gerekse debasın işletmelerinin reklam gelirleri olmadan ayaktakalabilmesinin yarattığı sıkıntılar, basın işletmelerini oldukçazor şartların içine sürüklemiştir. Özellikle Türk basın sektörüiçerisinde yer alan ‘söz sahibi’ kurumların tamamının büyükholdinglerin bünyesi altında faaliyetlerine devam etmeleri,sektörü kendi içerisinde farklı bir konuma getirmiştir.Finansal anlamda güçlü bir desteğin varlığının yanında,dağıtım olanaklarından her mecrada yer almaya kadar birçokavantaja sahip olan holding bünyesi altındaki basınişletmeleri, zaman içerisinde bu avantajlarının meydanagetirdiği ve Türk basını için büyük bir tehdit oluşturan‘tekelleşme’ olgusunu ortaya çıkarmışlardır. Bu çalışmada,öncelikli olarak Türk basın sektörü hakkında bilgilerverilecektir. Daha sonra ise, Türk basın sektörü içerisindeholdingleşme ekseninde tekelleşme sorununun ortayaçıkardığı olumsuz durumlarla ilgili değerlendirmelerdebulunularak, çözüm yollarına ilişkin saptamalar yapılacaktır.Abstract:Media companies must have a strong financialstructure in order to continue their existence and operations intoday’s economic conditions. One of the most important termof having strong financial condition for media companies is tomaintain a positive increase between incomes and expenses.However, considering the harsh competitive environment inmedia sector and problems created by difficulties in order

Conceptual design for the Waste Receiving and Processing facility Module 2A

International Nuclear Information System (INIS)

1992-07-01

This is part of a Conceptual Design Report (CDR) for the Waste Receiving and Processing (WRAP) Module 2A facility at Hanford Reservation. The mission of the WRAP Module 2A facility is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities those contact handled (CH) low-level radioactive mixed wastes (LLMW) that: (1) are currently in retrievable storage at the Hanford Central Waste Complex (HCWC) awaiting a treatment capability to permit permanent disposal compliant with the Land Disposal Restrictions and; (2) are forecasted to be generated over the next 30 years. The primary sources of waste to be treated at WRAP Module 2A include the currently stored waste from the 183-H solar basin evaporators, secondary solids from the future Hanford site liquid effluenttreatment facilities, thermal treatment facility ash, other WRAP modules, and other miscellaneous waste from storage and onsite/offsite waste generators consisting of compactible and non-compactible solids, contaminated soils, and metals. This volume, Volume V, provides a comprehensive conceptual design level narrative description of the process, utility, ventilation, and plant control systems. The feeds and throughputs, design requirements, and basis for process selection are provided, as appropriate. Key DOE/WHC criteria and reference drawings are delineated

Nonlinear modulation near the Lighthill instability threshold in 2+1 Whitham theory

Science.gov (United States)

Bridges, Thomas J.; Ratliff, Daniel J.

2018-04-01

The dispersionless Whitham modulation equations in 2+1 (two space dimensions and time) are reviewed and the instabilities identified. The modulation theory is then reformulated, near the Lighthill instability threshold, with a slow phase, moving frame and different scalings. The resulting nonlinear phase modulation equation near the Lighthill surfaces is a geometric form of the 2+1 two-way Boussinesq equation. This equation is universal in the same sense as Whitham theory. Moreover, it is dispersive, and it has a wide range of interesting multi-periodic, quasi-periodic and multi-pulse localized solutions. For illustration the theory is applied to a complex nonlinear 2+1 Klein-Gordon equation which has two Lighthill surfaces in the manifold of periodic travelling waves. This article is part of the theme issue `Stability of nonlinear waves and patterns and related topics'.

Conceptual design for the Waste Receiving and Processing facility Module 2A

International Nuclear Information System (INIS)

1992-07-01

This is a Conceptual Design Report (CDR) for the Waste Receiving and Processing (WRAP) Module 2A facility at Hanford Reservation. The mission of the WRAP Module 2A facility is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities those contact handled (CH) low-level radioactive mixed wastes (LLMW) that: (1) are currently in retrievable storage at the Hanford Central Waste Complex (HCWC) awaiting a treatment capability to permit permanent disposal compliant with the Land Disposal Restrictions and; (2) are forecasted to be generated over the next 30 years. The primary sources of waste to be treated at WRAP Module 2A include the currently stored waste from the 183-H solar basin evaporators, secondary solids from the future Hanford site liquid effluent treatment facilities, thermal treatment facility ash, other WRAP modules, and other, miscellaneous waste from storage and onsite/offsite waste generators consisting of compactible and non-compactible solids, contaminated soils, and metals. This volume, Volume 1 provides a narrative of the project background, objective and justification. A description of the WRAP 2A mission, operations and project scope is also included. Significant project requirements such as security, health, safety, decontamination and decomissioning, maintenance, data processing, and quality are outlined. Environmental compliance issues and regulatory permits are identified, and a preliminary safety evaluation is provided

Development and testing of shingle-type solar cell modules. Quarterly report No. 2

Energy Technology Data Exchange (ETDEWEB)

Shepard, N.F.

1978-01-05

The details of a shingle module design which produces in excess of 97 watts/m/sup 2/ of module area at 1 kW/m/sup 2/ insolation and at 60/sup 0/C are reported. This selected design employs a tempered glass coverplate to provide the primary solar cell structural support. The use of the B.F. Goodrich FLEXSEAL roofing system as the outer skin of the shingle substrate provides a high confidence of achieving the 15 year service life goal. The fabrication and testing of a preproduction module of this design has demonstrated that this selected approach will meet the environmental testing requirements imposed by the contract. Attempts to fabricate a preproduction module of an alternative design, which embeds the solar cell assembly within a methyl methacrylate casting, proved unsuccessful.

SH2 domains: modulators of nonreceptor tyrosine kinase activity

OpenAIRE

Filippakopoulos, Panagis; Müller, Susanne; Knapp, Stefan

2009-01-01

The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localization, substrate recruitment, and regulation of kinase activity. Initially, structural studies established a role of the SH2 domain stabilizing the inactive state of Src family members. However, biochemical characterization showed ...

The multi-dimensional module of CATHARE 2 description and application

Energy Technology Data Exchange (ETDEWEB)

Barre, F.; Dor, I.; Sun, C. [French Atomic Energy Commission (C.E.A.), Grenoble (France)

1995-09-01

In this paper, the three-dimensional module of CATHARE 2 is presented. It is based on a two-phase-flow six-equation model. A predictor/corrector multistep method, with an implicit behavior, is used to discretize the equations. Blowdown and boil-of analytical tests are used for an initial validation of the module. UPTF downcomer refill tests simulating the refill phase of a large-break loss-of-coolant accident are calculated. Additional models, including molecular and turbulent diffusion, are added in order to perform containment calculations.

The multi-dimensional module of CATHARE 2 description and application

International Nuclear Information System (INIS)

Barre, F.; Dor, I.; Sun, C.

1995-01-01

In this paper, the three-dimensional module of CATHARE 2 is presented. It is based on a two-phase-flow six-equation model. A predictor/corrector multistep method, with an implicit behavior, is used to discretize the equations. Blowdown and boil-of analytical tests are used for an initial validation of the module. UPTF downcomer refill tests simulating the refill phase of a large-break loss-of-coolant accident are calculated. Additional models, including molecular and turbulent diffusion, are added in order to perform containment calculations

/ı/ Türkçede Bir Anasesbirim midir? Is The Letter of /ı/ Archiphoneme In Turkish?

Directory of Open Access Journals (Sweden)

Fatih ÖZEK

2013-03-01

Full Text Available We can mention two letters of /ı/ in world languages. One ofthem is /ı/ (ы vowel called "yeri" in Russian language and the other is/ı/ vowel that is designated with [ï] in alphabet of internationaltranscription and that almost belongs to the Turkish language. The /ı/vowel of the Turkish language is a velarized, narrow, flat velum vowel interms of its characteristic features. It has normal duration. /a/, /i/ and/u/ vowels are generally deemed as cardinal vowels of the Turkishlanguage. According to this common view, eight vowels in the Turkishlanguage derived from these vowels. However, A.N. Baskakov thinksthat /ı/ is an archiphoneme and [i,u,ü] vowels are variants of the /ı/phoneme. This different view has had an influence on issuance of thispaper. It is possible to define the archiphoneme as main voicecontaining characteristics of more than one voice or first known voicesof a language. The archiphonemes are strong voices. They usually retaintheir existences. However, such characteristics are not seen in /ı/phoneme. Following determinations can be considered as evidenceshereof:1. qlıç (~ qılıç [cliç, cliz/kiliç] writings in Codex Cumanicus,2. Front palatalization of the /ı/ vowel in the first syllable (Uigur biş- ~ bış-‘mature, age out ’; Khorezm biş-; Kipchak biş- ~ piş-; Chagatai piş-; ETT piş-; Bashkir,Tatar, Turkmen, Azerbaijani biş-; Kazakh pis-; Uzbek, New Uigur, Gagauz, Trk. piş- Dünya dillerinde iki tane /ı/’dan bahsedilebilir. Bunlardan bir tanesi Rusça “yeri” adı verilen /ı/ (ы ünlüsü, diğeri ise uluslar arası transkripsiyon alfabesinde [ï] işaretiyle gösterilen ve neredeyse tamamen Türkçeye ait olan /ı/ ünlüsüdür. Türkçeye has /ı/ ünlüsü nitelik özellikleri bakımından kalın, dar, düz bir art damak ünlüsüdür. Nicelik bakımından ise normal sürelidir. /a/, /i/ ve /u/ ünlüleri genel olarak Türkçenin temel ünlüleri olarak kabul edilir. Bu yaygın görüşe g

Modulation of Nrf2 by Olive Oil and Wine Polyphenols and Neuroprotection

Directory of Open Access Journals (Sweden)

Miriam Martínez-Huélamo

2017-09-01

Full Text Available Strong adherence to a Mediterranean diet is associated with improved cognitive function and a lower prevalence of mild cognitive impairment. Olive oil and red wine are rich sources of polyphenols which are responsible in part for the beneficial effects on cognitive functioning. Polyphenols induce endogenous antioxidant defense mechanisms by modulating transcription factors such as the nuclear factor (erythroid-derived 2-like 2 (Nrf2. This review discusses the scientific data supporting the modulating effect of olive oil and red wine polyphenols on Nrf2 expression, and the potential health benefits associated with cognitive functioning.

MTR2: a discriminator and dead-time module used in counting systems

International Nuclear Information System (INIS)

Bouchard, J.

2000-01-01

In the field of radioactivity measurement, there is a constant need for highly specialized electronic modules such as ADCs, amplifiers, discriminators, dead-time modules, etc. But sometimes it is almost impossible to find on the market the modules having the performances corresponding to our needs. The purpose of the module presented here, called MTR2 (Module de Temps-mort Reconductible), is to process, in terms of pulse height discrimination and dead-time corrections, the pulses delivered by the detectors used in counting systems. This dead-time, of the extendible type, is triggered by both the positive and negative parts of the incoming pulse and the dead-time corrections are made according to the live-time method. This module, which has been developed and tested at LPRI, can be used alone in simple counting channels or in more complex systems such as coincidence systems. The philosophy governing the choice and the implementation of this type of dead-time as well as the system used for the dead-time corrections is presented. The electronic scheme and the performances are also presented. This module is available in the NIM standard

[Sudden and fatal malfunction of a Björk-Shiley prosthesis in mitral position due to rupture of the ventricular bracket and disk embolization].

Science.gov (United States)

Casarotto, D; Motta, A; Fabbri, A; Pugliese, P; Muneretto, C; Zanini, M; Sheiban, I

1985-04-01

Mechanical complications of prosthetic valves are increasing. The following report describes a case of fracture of a Björk-Shiley mitral prosthetic strut with dislogment of the valve occluder into the thoracic aorta. At the reoperation a new prosthesis was implanted but the patient died of acute heart failure. The diagnosis of valve disfunction must be made non invasively, because the time required for cardiac catherization usually constitutes a lethal delay. The only hope for survival is prompt surgical treatment.

H2O2 modulates the energetic metabolism of the cloud microbiome

Directory of Open Access Journals (Sweden)

N. Wirgot

2017-12-01

Full Text Available Chemical reactions in clouds lead to oxidation processes driven by radicals (mainly HO⚫, NO3⚫, or HO2⚫ or strong oxidants such as H2O2, O3, nitrate, and nitrite. Among those species, hydrogen peroxide plays a central role in the cloud chemistry by driving its oxidant capacity. In cloud droplets, H2O2 is transformed by microorganisms which are metabolically active. Biological activity can therefore impact the cloud oxidant capacity. The present article aims at highlighting the interactions between H2O2 and microorganisms within the cloud system. First, experiments were performed with selected strains studied as a reference isolated from clouds in microcosms designed to mimic the cloud chemical composition, including the presence of light and iron. Biotic and abiotic degradation rates of H2O2 were measured and results showed that biodegradation was the most efficient process together with the photo-Fenton process. H2O2 strongly impacted the microbial energetic state as shown by adenosine triphosphate (ATP measurements in the presence and absence of H2O2. This ATP depletion was not due to the loss of cell viability. Secondly, correlation studies were performed based on real cloud measurements from 37 cloud samples collected at the PUY station (1465 m a.s.l., France. The results support a strong correlation between ATP and H2O2 concentrations and confirm that H2O2 modulates the energetic metabolism of the cloud microbiome. The modulation of microbial metabolism by H2O2 concentration could thus impact cloud chemistry, in particular the biotransformation rates of carbon compounds, and consequently can perturb the way the cloud system is modifying the global atmospheric chemistry.

H2O2 modulates the energetic metabolism of the cloud microbiome

Science.gov (United States)

Wirgot, Nolwenn; Vinatier, Virginie; Deguillaume, Laurent; Sancelme, Martine; Delort, Anne-Marie

2017-12-01

Chemical reactions in clouds lead to oxidation processes driven by radicals (mainly HO⚫, NO3⚫, or HO2⚫) or strong oxidants such as H2O2, O3, nitrate, and nitrite. Among those species, hydrogen peroxide plays a central role in the cloud chemistry by driving its oxidant capacity. In cloud droplets, H2O2 is transformed by microorganisms which are metabolically active. Biological activity can therefore impact the cloud oxidant capacity. The present article aims at highlighting the interactions between H2O2 and microorganisms within the cloud system. First, experiments were performed with selected strains studied as a reference isolated from clouds in microcosms designed to mimic the cloud chemical composition, including the presence of light and iron. Biotic and abiotic degradation rates of H2O2 were measured and results showed that biodegradation was the most efficient process together with the photo-Fenton process. H2O2 strongly impacted the microbial energetic state as shown by adenosine triphosphate (ATP) measurements in the presence and absence of H2O2. This ATP depletion was not due to the loss of cell viability. Secondly, correlation studies were performed based on real cloud measurements from 37 cloud samples collected at the PUY station (1465 m a.s.l., France). The results support a strong correlation between ATP and H2O2 concentrations and confirm that H2O2 modulates the energetic metabolism of the cloud microbiome. The modulation of microbial metabolism by H2O2 concentration could thus impact cloud chemistry, in particular the biotransformation rates of carbon compounds, and consequently can perturb the way the cloud system is modifying the global atmospheric chemistry.

Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling*

Science.gov (United States)

Moreno, Estefanía; Andradas, Clara; Medrano, Mireia; Caffarel, María M.; Pérez-Gómez, Eduardo; Blasco-Benito, Sandra; Gómez-Cañas, María; Pazos, M. Ruth; Irving, Andrew J.; Lluís, Carme; Canela, Enric I.; Fernández-Ruiz, Javier; Guzmán, Manuel; McCormick, Peter J.; Sánchez, Cristina

2014-01-01

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology. PMID:24942731

A porous silica rock ("tripoli") in the footwall of the Jurassic Úrkút manganese deposit, Hungary: composition, and origin through carbonate dissolution

Science.gov (United States)

Polgari, Marta; Szabo, Zoltan; Szabo-Drubina, Magda; Hein, James R.; Yeh, Hsueh-Wen

2005-01-01

The mineralogical, chemical, and isotopic compositions were determined for a white tripoli from the footwall of the Jurassic Úrkút Mn-oxide ore deposit in the Bakony Mountains, Hungary. The tripoli consists of quartz and chalcedony, with SiO2 contents up to 100 wt.%; consequently, trace-element contents are very low. Oxygen isotopes and quartz crystallinity indicate a low-temperature diagenetic origin for this deposit. The tripoli was formed by dissolution of the carbonate portion of the siliceous (sponge spicules) Isztimér Limestone. Dissolution of the carbonate was promoted by inorganic and organic acids generated during diagensis and left a framework composed of diagenetic silica that preserved the original volume of the limestone layer. The relative enrichment of silica and high porosity is the result of that carbonate dissolution. The silty texture of this highly friable rock is due to the structurally weak silica framework.

Intensity Modulation Techniques for Continuous-Wave Lidar for Column CO2 Measurements

Science.gov (United States)

Campbell, J. F.; Lin, B.; Obland, M. D.; Kooi, S. A.; Fan, T. F.; Meadows, B.; Browell, E. V.; Erxleben, W. H.; McGregor, D.; Dobler, J. T.; Pal, S.; O'Dell, C.

2017-12-01

Global and regional atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission and the Atmospheric Carbon and Transport (ACT) - America project are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity-Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space and airborne platforms to meet the ASCENDS and ACT-America science measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) and Linear Swept Frequency modulations to uniquely discriminate surface lidar returns from intermediate aerosol and cloud returns. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that take advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques and provides very high (at sub-meter level) range resolution. We compare BPSK to linear swept frequency and introduce a new technique to eliminate sidelobes in situations from linear swept frequency where the SNR is high with results that rival BPSK. We also investigate the effects of non-linear modulators, which can in some circumstances degrade the orthogonality of the waveforms, and show how to avoid this. These techniques are used in a new data processing architecture written in

EOSN: A TOUGH2 module for noble gases

Energy Technology Data Exchange (ETDEWEB)

Shan, Chao; Pruess, Karsten

2003-03-07

We developed a new fluid property module for TOUGH2, called EOSN, to simulate transport of noble gases in the subsurface. Currently, users may select any of five different noble gases as well as CO2, two at a time. For the three gas components (air and two user-specified noble gases) in EOSN, the Henry's coefficients and the diffusivities in the gas phase are no longer assumed constants, but are temperature dependent. We used the Crovetto et al. (1982) model to estimate Henry's coefficients, and the Reid et al. (1987) correlations to calculate gas phase diffusivities. The new module requires users to provide names of the selected noble gases, which properties are provided internally. There are options for users to specify any (non-zero) molecular weights and half-lives for the gas components. We provide two examples to show applications of TOUGH2IEOSN. While temperature effects are relatively insignificant for one example problem where advection is dominant, they cause almost an order of magnitude difference for the other case where diffusion becomes a dominant process and temperature variations are relatively large. It appears that thermodynamic effects on gas diffusivities and Henry's coefficients can be important for low-permeability porous media and zones with large temperature variations.

EOSN: A TOUGH2 module for noble gases

International Nuclear Information System (INIS)

Shan, Chao; Pruess, Karsten

2003-01-01

We developed a new fluid property module for TOUGH2, called EOSN, to simulate transport of noble gases in the subsurface. Currently, users may select any of five different noble gases as well as CO2, two at a time. For the three gas components (air and two user-specified noble gases) in EOSN, the Henry's coefficients and the diffusivities in the gas phase are no longer assumed constants, but are temperature dependent. We used the Crovetto et al. (1982) model to estimate Henry's coefficients, and the Reid et al. (1987) correlations to calculate gas phase diffusivities. The new module requires users to provide names of the selected noble gases, which properties are provided internally. There are options for users to specify any (non-zero) molecular weights and half-lives for the gas components. We provide two examples to show applications of TOUGH2IEOSN. While temperature effects are relatively insignificant for one example problem where advection is dominant, they cause almost an order of magnitude difference for the other case where diffusion becomes a dominant process and temperature variations are relatively large. It appears that thermodynamic effects on gas diffusivities and Henry's coefficients can be important for low-permeability porous media and zones with large temperature variations

In vitro manganese-dependent cross-talk between Streptococcus mutans VicK and GcrR: implications for overlapping stress response pathways.

Directory of Open Access Journals (Sweden)

Jennifer S Downey

Full Text Available Streptococcus mutans, a major acidogenic component of the dental plaque biofilm, has a key role in caries etiology. Previously, we demonstrated that the VicRK two-component signal transduction system modulates biofilm formation, oxidative stress and acid tolerance responses in S. mutans. Using in vitro phosphorylation assays, here we demonstrate for the first time, that in addition to activating its cognate response regulator protein, the sensor kinase, VicK can transphosphorylate a non-cognate stress regulatory response regulator, GcrR, in the presence of manganese. Manganese is an important micronutrient that has been previously correlated with caries incidence, and which serves as an effector of SloR-mediated metalloregulation in S. mutans. Our findings supporting regulatory effects of manganese on the VicRK, GcrR and SloR, and the cross-regulatory networks formed by these components are more complex than previously appreciated. Using DNaseI footprinting we observed overlapping DNA binding specificities for VicR and GcrR in native promoters, consistent with these proteins being part of the same transcriptional regulon. Our results also support a role for SloR as a positive regulator of the vicRK two component signaling system, since its transcription was drastically reduced in a SloR-deficient mutant. These findings demonstrate the regulatory complexities observed with the S. mutans manganese-dependent response, which involves cross-talk between non-cognate signal transduction systems (VicRK and GcrR to modulate stress response pathways.

Outlet strut fracture of Björk-Shiley convexo-concave valves: can valve-manufacturing characteristics explain the risk?

Science.gov (United States)

Omar, R Z; Morton, L S; Beirne, M; Blot, W J; Lawford, P V; Hose, R; Taylor, K M

2001-06-01

Björk-Shiley 60 degrees convexo-concave prosthetic heart valves (Shiley, Inc, Irvine, Calif, a subsidiary of Pfizer, Inc) continue to be a concern for approximately 35,000 nonexplanted patients worldwide, with approximately 600 events reported to the manufacturer to date. Fractures of the outlet struts of the valves began to appear in the early 1980s and have continued to the present, but their causes are only partially understood. A matched case-control study was conducted evaluating manufacturing records for 52 valves with outlet strut fractures and 248 control subjects matched for age at implantation, valve size, and valve position. In addition to the risk factors recognized as determinants of outlet strut fracture, the United Kingdom case-control study has observed 7- to 9-fold increased risk with performance of multiple hook deflection tests. This test was performed more than once, usually after rework on the valve. Six valves in this study underwent multiple hook deflection tests, of which 4 experienced an outlet strut fracture. Cracks and further rework were noted for these valves. Significant associations were also observed between outlet strut fracture and disc-to-strut gap measurements taken before the attachment of the sewing ring. It is our view that a combination of factors related to valve design, manufacturing process, and patient characteristics are responsible for outlet strut fractures of Björk-Shiley convexo-concave valves. Multiple hook deflection tests have emerged as a potential new risk factor for outlet strut fracture in both The Netherlands and the United Kingdom. This factor appears to be correlated with the presence of other abnormalities. A further study is needed to investigate the factors correlated with multiple hook deflection tests. On confirmation of risk, the presence of multiple hook deflection tests may be added to equations, quantifying the risk of outlet strut fracture for comparison against risk of mortality and serious

Ammonia. Training Module 5.110.2.77.

Science.gov (United States)

Kirkwood Community Coll., Cedar Rapids, IA.

This document is an instructional module package prepared in objective form for use by an instructor familiar with analytical procedures for determining ammonia nitrogen concentrations in a water or wastewater sample. Included are objectives, instructor guides, student handouts, and transparency masters. This module considers preliminary…

Advanced intensity-modulation continuous-wave lidar techniques for ASCENDS CO2 column measurements

Science.gov (United States)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. W.; Obland, Michael D.; Meadows, Byron

2015-10-01

Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for ASCENDS O2 Column Measurements

Science.gov (United States)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. Wallace; Obland, Michael D.; Meadows, Byron

2015-01-01

Global atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity- Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud contamination. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby eliminating the need to correct for sidelobe bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. This approach works well for both BPSK and linear swept-frequency modulation techniques. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. A comparison of BPSK and linear swept-frequency is also discussed in this paper. These results are extended to include Richardson-Lucy deconvolution techniques to extend the resolution of the lidar beyond that implied by limit of the bandwidth of the modulation, where it is shown useful for making tree canopy measurements.

2D materials in electro-optic modulation: energy efficiency, electrostatics, mode overlap, material transfer and integration

Science.gov (United States)

Ma, Zhizhen; Hemnani, Rohit; Bartels, Ludwig; Agarwal, Ritesh; Sorger, Volker J.

2018-02-01

Here we discuss the physics of electro-optic modulators deploying 2D materials. We include a scaling laws analysis and show how energy-efficiency and speed change for three underlying cavity systems as a function of critical device length scaling. A key result is that the energy-per-bit of the modulator is proportional to the volume of the device, thus making the case for submicron-scale modulators possible deploying a plasmonic optical mode. We then show how Graphene's Pauli-blocking modulation mechanism is sensitive to the device operation temperature, whereby a reduction of the temperature enables a 10× reduction in modulator energy efficiency. Furthermore, we show how the high-index tunability of graphene is able to compensate for the small optical overlap factor of 2D-based material modulators, which is unlike classical silicon-based dispersion devices. Lastly, we demonstrate a novel method towards a 2D material printer suitable for cross-contamination free and on-demand printing. The latter paves the way to integrate 2D materials seamlessly into taped-out photonic chips.

NCS-1 associates with adenosine A2A receptors and modulates receptor function

Directory of Open Access Journals (Sweden)

Gemma eNavarro

2012-04-01

Full Text Available Modulation of G protein-coupled receptor (GPCR signalling by local changes in intracellular calcium concentration is an established function of Calmodulin which is known to interact with many GPCRs. Less is known about the functional role of the closely related neuronal EF-hand Ca2+-sensor proteins that frequently associate with calmodulin targets with different functional outcome. In the present study we aimed to investigate if a target of calmodulin – the A2A adenosine receptor, is able to associate with two other neuronal calcium binding proteins, namely NCS-1 and caldendrin. Using bioluminescence resonance energy transfer and co-immunoprecipitation experiments we show the existence of A2A - NCS-1 complexes in living cells whereas caldendrin did not associate with A2A receptors under the conditions tested. Interestingly, NCS-1 binding modulated downstream A2A receptor intracellular signalling in a Ca2+-dependent manner. Taken together this study provides further evidence that neuronal Ca2+-sensor proteins play an important role in modulation of GPCR signalling.

Turbidity. Training Module 5.240.2.77.

Science.gov (United States)

Bonte, John L.; Davidson, Arnold C.

This document is an instructional module package prepared in objective form for use by an instructor familiar with candle turbidimeter and the nephelometric method of turbidity analysis. Included are objectives, an instructor guide, student handout, and transparency masters. A video tape is also available from the author. This module considers use…

Osmanlı Modernleşmesinde Jön-Türk Hareketinin Din-Siyaset Anlayışı

Directory of Open Access Journals (Sweden)

Nadim Macit

2015-11-01

Full Text Available Osmanlı modernleşmesinin son döneminde ortaya çıkan siyasi akımları incelemek bir taraftan ekonomik, teknolojik ve siyasi gelişmelerin , kültür ve düşün alanlarında ortaya çıkan felsefi hareketlerin Osmanlı toplumuna etkisini; diğer taraftan da siyasi düzenin koşullarını ve mekanizmasını oluşturan ögelerin değişimini çözümlemek anlamına gelir. Bu meselenin ana noktasını , son dönemdeki modernleşme çabalarının toplumda, özellikle seçkinler arasında ortaya çıkarttığı çatışma ve ayrışma ekseni ile "Jön Türk" hareketinin bu eksende aldığı yerin ne olduğu hususu oluşturmaktadır.

Experimental study on the thrust modulation performance of powdered magnesium and CO2 bipropellant engine

Science.gov (United States)

Li, Chao; Hu, Chunbo; Zhu, Xiaofei; Hu, Jiaming; Li, Yue; Hu, Xu

2018-06-01

Powdered Mg and CO2 bipropellant engine providing a practical demonstration of in situ resource utilization (ISRU) for Mars Sample Return (MSR) mission seems to be feasible by current investigations. However, essential functions of the engine to satisfy the complicated ballistics requirements such as thrust modulation and multiple pulse have not been established yet. The aim of this experimental study is to evaluate the engine's thrust modulation feasibility and to investigate its thrust modulation characteristics. A powdered Mg and CO2 bipropellant engine construction aiming to achieve thrust modulation ability was proposed. A mass flow rate calibration experiment to evaluate the gas-solid mass flow rate regulating performance was conducted before fire tests. Fire test result shows that the engine achieved successful ignition as well as self-sustaining combustion; Thrust modulation of the engine is feasible, detail thrust estimating result of the test shows that maximum thrust is 135.91 N and the minimum is 5.65 N with a 22.11 thrust modulation ratio, moreover, the transportation period is quick and the thrust modulation ratio is adjustable. At the same time, the powder feed system reaches a two-step flow rate regulating with a modulation ratio of 4.5-5. What' more, caused by the uneven engine working conditions, there is an obvious difference in combustion efficiency value, maximum combustion efficiency of the powdered Mg and CO2 bipropellant engine is 80.20%.

The SHOCT domain: a widespread domain under-represented in model organisms.

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Ruth Y Eberhardt

Full Text Available We have identified a new protein domain, which we have named the SHOCT domain (Short C-terminal domain. This domain is widespread in bacteria with over a thousand examples. But we found it is missing from the most commonly studied model organisms, despite being present in closely related species. It's predominantly C-terminal location, co-occurrence with numerous other domains and short size is reminiscent of the Gram-positive anchor motif, however it is present in a much wider range of species. We suggest several hypotheses about the function of SHOCT, including oligomerisation and nucleic acid binding. Our initial experiments do not support its role as an oligomerisation domain.

Conceptual design for the Waste Receiving And Processing facility Module 2A

International Nuclear Information System (INIS)

1992-07-01

This Conceptual Design Report (CDR) for the Waste Receiving and Processing (WRAP) Module 2A facility. The mission of the WRAP Module 2A facility is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities those contact handled (CH) low-level radioactive mixed wastes (LLMW) that: (1) are currently in retrievable storage at the Hanford Central Waste Complex (HCWC) awaiting a treatment capability to permit permanent disposal compliant with the Land Disposal Restrictions and; (2) are forecasted to be generated over the next 30 years. This volume provides the detailed cost estimate for the WRAP 2A facility. Included in this volume is the project construction schedule

Changes in modulation period of Bi 2Sr 2 (Ca 1- xNd x) Cu 2O a + δ and their relations to oxygen content

Science.gov (United States)

Onozuka, Takashi; Tokiwa, Ayako; Syono, Yasuhiko; Koike, Yoji; Saito, Yoshitami

1991-12-01

Structural changes of long-period modulated structure (LPMS) of the Bi 2Sr 2(Ca 1- xNd x) Cu 2O a + δ ceramics with x are investigated by means of electron diffraction. Increasing x, the modulation mode of the mixing of domains of two modulation periods with b=4.5b o and b=5b o changes to that with b=4.5b o and b=4b o through the modulation mode with only b=4.5b o at x=0.4-0.5. The wavenumber of the superlattice reflection shows a stepwise increase rather than a linear increase with x. Excess oxygen in a LPMS model with the site of excess oxygen is shown to be consistent with excess oxygen analyzed chemically by iodometry and its change with x.

Novel Abscisic Acid Antagonists Identified with Chemical Array Screening.

Science.gov (United States)

Ito, Takuya; Kondoh, Yasumitsu; Yoshida, Kazuko; Umezawa, Taishi; Shimizu, Takeshi; Shinozaki, Kazuo; Osada, Hiroyuki

2015-11-01

Abscisic acid (ABA) signaling is involved in multiple processes in plants, such as water stress control and seed dormancy. Major regulators of ABA signaling are the PYR/PYL/RCAR family receptor proteins, group A protein phosphatases 2C (PP2Cs), and subclass III of SNF1-related protein kinase 2 (SnRK2). Novel ABA agonists and antagonists to modulate the functions of these proteins would not only contribute to clarification of the signaling mechanisms but might also be used to improve crop yields. To obtain small molecules that interact with Arabidopsis ABA receptor PYR1, we screened 24 275 compounds from a chemical library at the RIKEN Natural Products Depository by using a chemical array platform. Subsequent SnRK2 and PP2C assays narrowed down the candidates to two molecules. One antagonized ABA in a competitive manner and inhibited the formation of the PYR1-ABA-PP2C ternary complex. These compounds might have potential as bioprobes to analyze ABA signaling. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Pulsed modulator power supply for the g-2 muon storage ring injection kicker

NARCIS (Netherlands)

Mi, J.; Lee, Y. Y.; Morse, W. M.; Pai, C. I.; Pappas, G. C.; Sanders, R.; Semertzidis, Y. K.; Warburton, D.; Zapasek, R.; Jungmann, K.; Roberts, L.

1999-01-01

This paper describes the pulse modulator power supplies used to drive the kicker magnets that inject the muon beam into the g-2 storage ring that has been built at Brookhaven National Laboratory. Three modulators built into coaxial structures consisting of a series circuit of an energy storage

The design and PCB layout of the CDF Run 2 calorimetry readout module

International Nuclear Information System (INIS)

Theresa Shaw

1999-01-01

The CDF Calorimetry Readout module, called the ADMEM, has been designed to contain both the analog circuitry which digitizes the phototube charge pulses, and the digital logic which supports the readout of the results through the CDF Run 2 DAQ system. The ADMEM module is a 9Ux400mm VMEbus module, which is housed in a CDF VMEbus VIPA crate. The ADMEM must support near deadtimeless operation, with data being digitized and stored for possible readout every 132ns or 7.6 Mhz. This paper will discuss the implementation of the analog and digital portions of the ADMEM module, and how the board was laid out to avoid the coupling of digital noise into the analog circuitry

Two-Dimensional SiO2/VO2 Photonic Crystals with Statically Visible and Dynamically Infrared Modulated for Smart Window Deployment.

Science.gov (United States)

Ke, Yujie; Balin, Igal; Wang, Ning; Lu, Qi; Tok, Alfred Iing Yoong; White, Timothy J; Magdassi, Shlomo; Abdulhalim, Ibrahim; Long, Yi

2016-12-07

Two-dimensional (2D) photonic structures, widely used for generating photonic band gaps (PBG) in a variety of materials, are for the first time integrated with the temperature-dependent phase change of vanadium dioxide (VO 2 ). VO 2 possesses thermochromic properties, whose potential remains unrealized due to an undesirable yellow-brown color. Here, a SiO 2 /VO 2 core/shell 2D photonic crystal is demonstrated to exhibit static visible light tunability and dynamic near-infrared (NIR) modulation. Three-dimensional (3D) finite difference time domain (FDTD) simulations predict that the transmittance can be tuned across the visible spectrum, while maintaining good solar regulation efficiency (ΔT sol = 11.0%) and high solar transmittance (T lum = 49.6%). Experiments show that the color changes of VO 2 films are accompanied by NIR modulation. This work presents a novel way to manipulate VO 2 photonic structures to modulate light transmission as a function of wavelength at different temperatures.

Genetic parameter estimation for long endurance trials in the Uruguayan Criollo horse.

Science.gov (United States)

López-Correa, R D; Peñagaricano, F; Rovere, G; Urioste, J I

2018-06-01

The aim of this study was to estimate the genetic parameters of performance in a 750-km, 15-day ride in Criollo horses. Heritability (h 2 ) and maternal lineage effects (mt 2 ) were obtained for rank, a relative placing measure of performance. Additive genetic and maternal lineage (rmt) correlations among five medium-to-high intensity phase ranks (pRK) and final rank (RK) were also estimated. Individual records from 1,236 Criollo horses from 1979 to 2012 were used. A multivariate threshold animal model was applied to the pRK and RK. Heritability was moderate to low (0.156-0.275). Estimates of mt 2 were consistently low (0.04-0.06). Additive genetic correlations between individual pRK and RK were high (0.801-0.924), and the genetic correlations between individual pRKs ranged from 0.763 to 0.847. The pRK heritabilities revealed that some phases were explained by a greater additive component, whereas others showed stronger genetic relationships with RK. Thus, not all pRK may be considered as similar measures of performance in competition. © 2018 Blackwell Verlag GmbH.

[Directions for reoperation of patients with Björk-Shiley convexo-concave valve prosthesis, based on long-term experience].

Science.gov (United States)

Yamaki, F; Nakano, K; Endo, M; Hashimoto, A; Koyanagi, H

1994-02-01

Although a high incidence of strut fracture of the Björk-Shiley convexo-concave (C-C) valve prosthesis has been reported, it is still controversial whether the prosthesis functioning normally should be replaced electively. To clarify our policy for this issue, we reviewed 28 patients who had undergone mitral valve replacement with a C-C valve prosthesis, and evaluated long-term results according to STS guidelines. The incidence of valve-related complications expressed as % patient-year were; structural deterioration 0.30, nonstructural dysfunction 0.30, thromboembolism 1.20. There were no thrombosed valves, anticoagulant-related hemorrhage or prosthetic valve endocarditis. The actuarial free rate after valve replacement with the C-C at 10 years, constructed by the Kaplan-Meier method, were compared with those with St. Jude Medical (SJM) valve prosthesis. (1) Actuarial survival: 77.9 vs 87.3 (NS), (2) Reoperation-free: 91.6 vs 98.0 (p valve-related complications: 71.2 vs 77.7 (NS). The long-term results with the C-C were compatible to those with a SJM valve prosthesis. However, if a strut fracture occurs, it is very difficult to save the patient's life. The hospital mortality of re-replacement of valve prosthesis during the last 10 years, at our institute, was 2.6%, which is almost equal to the cumulative risk of strut fracture of the C-C valve after 10 years (3.0%).(ABSTRACT TRUNCATED AT 250 WORDS)

Positron-annihilation 2D-ACAR measurements in the incommensurately modulated high-Tc superconductor Bi2Sr2CaCu2O8+x

International Nuclear Information System (INIS)

Mijnarends, P.E.; Melis, A.F.J.; Weeber, A.W.; Menovsky, A.A.; Kadowaki, K.; National Research Inst. for Metals, Tsukuba, Ibaraki

1990-12-01

Measurements are presented of the two-dimensional angular correlation of annihilation radiation (2D-ACAR) in a single crystal of approximate composition Bi 2 Sr 2 CaCu 2 O 8+x (T c =85 K) at 6 K and 92 K. Data taken with projection along the c axis show a strong C 2v symmetry due to the presence of an incommensurate modulation with wave vector q in the crystal structure, together with considerable fine-structure. It is shown theoretically that the modulation should cause images of the Fermi surface displaced over an integer times q relative to the usual high-momentum components. An analysis of the behaviour of the fine-structure in the 2D-ACAR distribution shows that many peaks change in intensity and width but little in position T is raised from 6 to 92 K. (author). 32 refs.; 6 figs

Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity*

Science.gov (United States)

Jin, Lily L.; Wybenga-Groot, Leanne E.; Tong, Jiefei; Taylor, Paul; Minden, Mark D.; Trudel, Suzanne; McGlade, C. Jane; Moran, Michael F.

2015-01-01

Src homology 2 (SH2) domains are modular protein structures that bind phosphotyrosine (pY)-containing polypeptides and regulate cellular functions through protein-protein interactions. Proteomics analysis showed that the SH2 domains of Src family kinases are themselves tyrosine phosphorylated in blood system cancers, including acute myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma. Using the Src family kinase Lyn SH2 domain as a model, we found that phosphorylation at the conserved SH2 domain residue Y194 impacts the affinity and specificity of SH2 domain binding to pY-containing peptides and proteins. Analysis of the Lyn SH2 domain crystal structure supports a model wherein phosphorylation of Y194 on the EF loop modulates the binding pocket that engages amino acid side chains at the pY+2/+3 position. These data indicate another level of regulation wherein SH2-mediated protein-protein interactions are modulated by SH2 kinases and phosphatases. PMID:25587033

Development and preliminary verification of 2-D transport module of radiation shielding code ARES

International Nuclear Information System (INIS)

Zhang Penghe; Chen Yixue; Zhang Bin; Zang Qiyong; Yuan Longjun; Chen Mengteng

2013-01-01

The 2-D transport module of radiation shielding code ARES is two-dimensional neutron and radiation shielding code. The theory model was based on the first-order steady state neutron transport equation, adopting the discrete ordinates method to disperse direction variables. Then a set of differential equations can be obtained and solved with the source iteration method. The 2-D transport module of ARES was capable of calculating k eff and fixed source problem with isotropic or anisotropic scattering in x-y geometry. The theoretical model was briefly introduced and series of benchmark problems were verified in this paper. Compared with the results given by the benchmark, the maximum relative deviation of k eff is 0.09% and the average relative deviation of flux density is about 0.60% in the BWR cells benchmark problem. As for the fixed source problem with isotropic and anisotropic scattering, the results of the 2-D transport module of ARES conform with DORT very well. These numerical results of benchmark problems preliminarily demonstrate that the development process of the 2-D transport module of ARES is right and it is able to provide high precision result. (authors)

Superstability for Generalized Module Left Derivations and Generalized Module Derivations on a Banach Module (I

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Huai-Xin Cao

2009-01-01

Full Text Available We discuss the superstability of generalized module left derivations and generalized module derivations on a Banach module. Let 𝒜 be a Banach algebra and X a Banach 𝒜-module, f:X→X and g:𝒜→𝒜. The mappings Δf,g1, Δf,g2, Δf,g3, and Δf,g4 are defined and it is proved that if ∥Δf,g1(x,y,z,w∥ (resp., ∥Δf,g3(x,y,z,w,α,β∥ is dominated by φ(x,y,z,w, then f is a generalized (resp., linear module-𝒜 left derivation and g is a (resp., linear module-X left derivation. It is also shown that if ∥Δf,g2(x,y,z,w∥ (resp., ∥Δf,g4(x,y,z,w,α,β∥ is dominated by φ(x,y,z,w, then f is a generalized (resp., linear module-𝒜 derivation and g is a (resp., linear module-X derivation.

Convergent-beam electron diffraction study of incommensurately modulated crystals. Pt. 2. (3 + 1)-dimensional space groups

International Nuclear Information System (INIS)

Terauchi, Masami; Takahashi, Mariko; Tanaka, Michiyoshi

1994-01-01

The convergent-beam electron diffraction (CBED) method for determining three-dimensional space groups is extended to the determination of the (3 + 1)-dimensional space groups for one-dimensional incommensurately modulated crystals. It is clarified than an approximate dynamical extinction line appears in the CBED discs of the reflections caused by an incommensurate modulation. The extinction enables the space-group determination of the (3 + 1)-dimensional crystals or the one-dimensional incommensurately modulated crystals. An example of the dynamical extinction line is shown using an incommensurately modulated crystal of Sr 2 Nb 2 O 7 . Tables of the dynamical extinction lines appearing in CBED patterns are given for all the (3 + 1)-dimensional space groups of the incommensurately modulated crystal. (orig.)

Solostamenides paucitesticulatus n. sp. (Monogenoidea: Mazocraeidea: Microcotylidae) from the freshwater mullet Liza abu (Heckel) (Mugiliformes: Mugilidae) from Atatürk Reservoir on the Euphrates River in southern Turkey.

Science.gov (United States)

Kritsky, Delane C; Öktener, Ahmet

2015-06-01

Solostamenides paucitesticulatus n. sp. (Monogenoidea: Microcotylidae) from the gills of the abu mullet Liza abu (Heckel) in Atatürk Reservoir in southern Turkey is described. Among other features, the new species is easily distinguished from its three congeners, Solostamenides mugilis (Vogt, 1879), Solostamenides pseudomugilis (Hargis, 1956) and Solostamenides polyorchis Zhang & Yang, 2001, by having fewer hooks on the male copulatory organ (11 to 14), testes (5 to 9), and haptoral clamps (31 to 47).

Steady-State-Preserving Simulation of Genetic Regulatory Systems

Directory of Open Access Journals (Sweden)

Ruqiang Zhang

2017-01-01

Full Text Available A novel family of exponential Runge-Kutta (expRK methods are designed incorporating the stable steady-state structure of genetic regulatory systems. A natural and convenient approach to constructing new expRK methods on the base of traditional RK methods is provided. In the numerical integration of the one-gene, two-gene, and p53-mdm2 regulatory systems, the new expRK methods are shown to be more accurate than their prototype RK methods. Moreover, for nonstiff genetic regulatory systems, the expRK methods are more efficient than some traditional exponential RK integrators in the scientific literature.

Heat capacity measurements on ThO2 by temperature modulated differential scanning calorimetry (TMDSC)

International Nuclear Information System (INIS)

Venkatakrishnan, R.; Nagarajan, K.; Vasudeva Rao, P.R.

2001-01-01

Heat capacity measurements were carried out on ThO 2 in the temperature range 330-820 K by using temperature modulated DSC. An underlying heating rate of 5 K. min -1 , a temperature modulation with an amplitude of 0.398K and a period of 150s were used for these measurements. The heat capacity values are within ± 2-4% of the literature data. (author)

Enhanced 2/3 four-ary modulation code using soft-decision Viterbi decoding for four-level holographic data storage systems

Science.gov (United States)

Kong, Gyuyeol; Choi, Sooyong

2017-09-01

An enhanced 2/3 four-ary modulation code using soft-decision Viterbi decoding is proposed for four-level holographic data storage systems. While the previous four-ary modulation codes focus on preventing maximum two-dimensional intersymbol interference patterns, the proposed four-ary modulation code aims at maximizing the coding gains for better bit error rate performances. For achieving significant coding gains from the four-ary modulation codes, we design a new 2/3 four-ary modulation code in order to enlarge the free distance on the trellis through extensive simulation. The free distance of the proposed four-ary modulation code is extended from 1.21 to 2.04 compared with that of the conventional four-ary modulation code. The simulation result shows that the proposed four-ary modulation code has more than 1 dB gains compared with the conventional four-ary modulation code.

Automated Transportation Management System (ATMS) V2.0 logistics module PBI acceptance criteria

International Nuclear Information System (INIS)

Weidert, R.S.

1995-01-01

This document defines the acceptance criteria for the Automated Transportation Management System V2.0 Logistics Module Performance Based Incentive (PBI). This acceptance criteria will be the primary basis for the generation of acceptance test procedures. The purpose of this document is to define the minimum criteria that must be fulfilled to guarantee acceptance of the Logistics Module

Standard Chinese: A Modular Approach. Student Workbook. Module 1: Orientation; Module 2: Biographic Information.

Science.gov (United States)

Defense Language Inst., Monterey, CA.

Texts in spoken Standard Chinese were developed to improve and update Chinese materials to reflect current usage in Beijing and Taipei. The focus is on communicating in Chinese in practical situations. The overall course is organized into 10 modules, student workbooks, and resource modules. This workbook covers the orientation and biographic…

Plasma-assisted CO2 conversion: optimizing performance via microwave power modulation

Science.gov (United States)

Britun, Nikolay; Silva, Tiago; Chen, Guoxing; Godfroid, Thomas; van der Mullen, Joost; Snyders, Rony

2018-04-01

Significant improvement in the energy efficiency of plasma-assisted CO2 conversion is achieved with applied power modulation in a surfaguide microwave discharge. The obtained values of CO2 conversion and energy efficiency are, respectively, 0.23 and 0.33 for a 0.95 CO2  +  0.05 N2 gas mixture. Analysis of the energy relaxation mechanisms shows that power modulation can potentially affect the vibrational-translational energy exchange in plasma. In our case, however, this mechanism does not play a major role, likely due to the low degree of plasma non-equilibrium in the considered pressure range. Instead, the gas residence time in the discharge active zone together with plasma pulse duration are found to be the main factors affecting the CO2 conversion efficiency at low plasma pulse repetition rates. This effect is confirmed experimentally by the in situ time-resolved two-photon absorption laser-induced fluorescence measurements of CO molecular density produced in the discharge as a result of CO2 decomposition.

Björk-Shiley convexoconcave valves: susceptibility artifacts at brain MR imaging and mechanical valve fractures.

Science.gov (United States)

van Gorp, Maarten J; van der Graaf, Yolanda; de Mol, Bas A J M; Bakker, Chris J G; Witkamp, Theo D; Ramos, Lino M P; Mali, Willem P T M

2004-03-01

To assess the relationship between heart valve history and susceptibility artifacts at magnetic resonance (MR) imaging of the brain in patients with Björk-Shiley convexoconcave (BSCC) valves. MR images of the brain were obtained in 58 patients with prosthetic heart valves: 20 patients had BSCC valve replacements, and 38 had other types of heart valves. Two experienced neuroradiologists determined the presence or absence of susceptibility artifacts in a consensus reading. Artifacts were defined as characteristic black spots that were visible on T2*-weighted gradient-echo MR images. The statuses of the 20 explanted BSCC valves-specifically, whether they were intact or had an outlet strut fracture (OSF) or a single-leg fracture (SLF)-had been determined earlier. Number of artifacts seen at brain MR imaging was correlated with explanted valve status, and differences were analyzed with nonparametric statistical tests. Significantly more patients with BSCC valves (17 [85%] of 20 patients) than patients with other types of prosthetic valves (18 [47%] of 38 patients) had susceptibility artifacts at MR imaging (P =.005). BSCC valve OSFs were associated with a significantly higher number of artifacts than were intact BSCC valves (P =.01). No significant relationship between SLF and number of artifacts was observed. Susceptibility artifacts at brain MR imaging are not restricted to patients with BSCC valves. These artifacts can be seen on images obtained in patients with various other types of fractured and intact prosthetic heart valves. Copyright RSNA, 2004

Functional tests of 2S modules for the CMS Phase-2 Tracker Upgrade with a MicroTCA-based readout system

CERN Document Server

Preuten, Marius; Klein, Katja; Lipinski, Martin; Rauch, Max; Feld, Lutz

2017-01-01

First full size 2S module prototypes for the CMS Phase-2 Outer Tracker Upgrade have been assembled. With two sensors of realistic dimensions and 16 CBC2 readout ASICs on two front-end hybrids, the characteristics of these novel and complex objects can be studied.A MicroTCA based readout system was developed to test multiple front-end hybrids simultaneously. Therefore the concurrent information of the full module can be used for noise and signal studies.

A Low-Cost Production Method of FeSi2 Power Generation Thermoelectric Modules

Science.gov (United States)

Inoue, Hiroyuki; Kobayashi, Takahide; Kato, Masahiko; Yoneda, Seiji

2016-03-01

A method is proposed to reduce the production cost of power generation thermoelectric modules. FeSi2 is employed as the thermoelectric material because of its low cost, low environmental load, and oxidation resistance. The raw materials were prepared in the composition of Fe0.96Si2.1Co0.04 for n-type and Fe0.92Si2.1Mn0.08 for p-type, which were added with 0.5 wt.% Cu as the starting materials. They were sintered without pressure at 1446 K to be formed into elements. The Seebeck coefficient and resistivity at room temperature were determined to be -182 μV/K and 0.13 mΩm for n-type, and 338 μV/K and 1.13 mΩm for p-type, respectively. The brazing conditions of the direct joining between the element and the solder were examined. Pastes of BNi-6, BNi-7 or TB-608T were tried as the solder. TB-608T was useable for metallizing of insulation substrates and joining of thermoelectric elements in order to manufacture thermoelectric modules. The joining strength was determined to be 50 MPa between the alumina plate and the elements. No mechanical failure was observed in the modules after repetition of 10 or more exposures to a heat source of 670 K. No change was found in the internal resistance. The present production method will provide modules with high durability and low production cost, which will enable high-power multi-stage cascade modules at a reasonable cost.

Strut fracture of Björk-Shiley convexo-concave valve in Japan--risk of small valve size--.

Science.gov (United States)

Watarida, S; Shiraishi, S; Nishi, T; Imura, M; Yamamoto, Y; Hirokawa, R; Fujita, M

2001-08-01

The Björk-Shiley convexo-concave (BSCC) prosthetic valve was introduced in 1979. Between 1979 and 1986, approximately 86,000 BSCC valves were implanted. By December 31, 1994, 564 complete strut fractures had been reported to the manufacture. We experienced a case of an outlet strut fracture and investigated the risk of BSCC prosthetic valve fractures in Japan. To investigate the risk factor of a strut fracture in Japan, we investigated published cases of strut fractures. Between 1979 and 1986, 2021 BSCC valves were implanted in Japan. By January 31, 2000, 11 complete strut fractures of 60-degree BSCC valves including our case had occurred. The patients were eight males and three females. The average age at valve replacement was 42.4+/-8.1 years, and nine of eleven (81.8%) were patients valve fractured was 47.7+/-6.4 years, and eight of eleven (72.7%) were patients valve were 27 mm (n=5) (45.5%), 29 mm (n=3) (27.2%), and 31 mm (n=3) (27.2%). Four patients died and seven patients survived. Although only 11 BSCC valve struts fractured and statistical analysis could not be performed, our findings suggest that the high risk group for a strut fracture in Japan is young male patients with a mitral valve, >= 27 mm in size with BSCC models manufactured before March 1982. When following-up patients with BSCC models manufactured before March 1982, the possibility of a strut fracture in all BSCC valve sizes should be kept in mind.

Standard Chinese: A Modular Approach. Student Text. Module 1: Orientation; Module 2: Biographic Information.

Science.gov (United States)

Defense Language Inst., Monterey, CA.

Texts in spoken Standard Chinese were developed to improve and update Chinese materials to reflect current usage in Beijing and Taipei. The focus is on communicating in Chinese in practical situations, and the texts summarize and supplement tapes. The overall course is organized into 10 situational modules, student workbooks, and resource modules.…

Türk Sucuklarında Ticari Starter Kültür Kullanımı Üzerine Araştırmalar II. Duyusal ve Mikrobiyolojik Analizler

Directory of Open Access Journals (Sweden)

Halil Vural

2015-02-01

Full Text Available Bu çalışmada; işletme düzeyinde kontrollü koşullarda Türk sucuğu üretiminde ticari starter kültürlerin kullanımı incelenmiştir. Bu amaçla, starter kültür katılmayan örnek kontrol grubu olarak alınarak, 7 farklı ticari starter kültürle hazırlanan 8 sucuk örneği aynı koşullarda denemeye alınmıştır. Sucuklara üretimin 7 kritik noktasına mezofilik aerobik bakteri, Lactobacillus-Pedicoccus ve patojen olmayan Staphylococcus-Micrococcus sayımı analizleri ile ürün bazında duyusal analizlerle starter kültür katılarak üretilen sucukların kontrol grubuna göre belirgin üstünlük sağladıkları belirlenmiş, kimyasal, mikrobiyolojik ve duyusal analiz bulgularının birlikte değerlendirilmesi; Türk sucuğu özelliklerine en uygun sonuçları Flora Carn SL ve Flora Carn SP starter kültürleri ile yapılan sucukların verdiğini göstermiştir.

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 Measurements

Science.gov (United States)

Campbell, J. F.; Lin, B.; Obland, M. D.; Liu, Z.; Kooi, S. A.; Fan, T. F.; Nehrir, A. R.; Meadows, B.; Browell, E. V.

2016-12-01

Advanced Intensity-Modulation Continuous-Wave Lidar Techniques for Column CO2 MeasurementsJoel F. Campbell1, Bing Lin1, Michael D. Obland1, Zhaoyan Liu1, Susan Kooi2, Tai-Fang Fan2, Amin R. Nehrir1, Byron Meadows1, Edward V. Browell31NASA Langley Research Center, Hampton, VA 23681 2SSAI, NASA Langley Research Center, Hampton, VA 23681 3STARSS-II Affiliate, NASA Langley Research Center, Hampton, VA 23681 AbstractGlobal and regional atmospheric carbon dioxide (CO2) measurements for the NASA Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) space mission and the Atmospheric Carbon and Transport (ACT) - America project are critical for improving our understanding of global CO2 sources and sinks. Advanced Intensity-Modulated Continuous-Wave (IM-CW) lidar techniques are investigated as a means of facilitating CO2 measurements from space and airborne platforms to meet the ASCENDS and ACT-America science measurement requirements. In recent numerical, laboratory and flight experiments we have successfully used the Binary Phase Shift Keying (BPSK) modulation technique to uniquely discriminate surface lidar returns from intermediate aerosol and cloud returns. We demonstrate the utility of BPSK to eliminate sidelobes in the range profile as a means of making Integrated Path Differential Absorption (IPDA) column CO2 measurements in the presence of optically thin clouds, thereby minimizing bias errors caused by the clouds. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate cloud layers, which is a requirement for the inversion of column CO2 number density measurements to column CO2 mixing ratios, has been demonstrated using new sub-meter hyperfine interpolation techniques that takes advantage of the periodicity of the modulation waveforms. The BPSK technique under investigation has excellent auto-correlation properties while possessing a finite bandwidth. These techniques are used in a new data processing

Whitham modulation theory for (2  +  1)-dimensional equations of Kadomtsev–Petviashvili type

Science.gov (United States)

Ablowitz, Mark J.; Biondini, Gino; Rumanov, Igor

2018-05-01

Whitham modulation theory for certain two-dimensional evolution equations of Kadomtsev–Petviashvili (KP) type is presented. Three specific examples are considered in detail: the KP equation, the two-dimensional Benjamin–Ono (2DBO) equation and a modified KP (m2KP) equation. A unified derivation is also provided. In the case of the m2KP equation, the corresponding Whitham modulation system exhibits features different from the other two. The approach presented here does not require integrability of the original evolution equation. Indeed, while the KP equation is known to be a completely integrable equation, the 2DBO equation and the m2KP equation are not known to be integrable. In each of the cases considered, the Whitham modulation system obtained consists of five first-order quasilinear partial differential equations. The Riemann problem (i.e. the analogue of the Gurevich–Pitaevskii problem) for the one-dimensional reduction of the m2KP equation is studied. For the m2KP equation, the system of modulation equations is used to analyze the linear stability of traveling wave solutions.

Modulator-free quadrature amplitude modulation signal synthesis

Science.gov (United States)

Liu, Zhixin; Kakande, Joseph; Kelly, Brian; O'Carroll, John; Phelan, Richard; Richardson, David J.; Slavík, Radan

2014-12-01

The ability to generate high-speed on-off-keyed telecommunication signals by directly modulating a semiconductor laser’s drive current was one of the most exciting prospective applications of the nascent field of laser technology throughout the 1960s. Three decades of progress led to the commercialization of 2.5 Gbit s-1-per-channel submarine fibre optic systems that drove the growth of the internet as a global phenomenon. However, the detrimental frequency chirp associated with direct modulation forced industry to use external electro-optic modulators to deliver the next generation of on-off-keyed 10 Gbit s-1 systems and is absolutely prohibitive for today’s (>)100 Gbit s-1 coherent systems, which use complex modulation formats (for example, quadrature amplitude modulation). Here we use optical injection locking of directly modulated semiconductor lasers to generate complex modulation format signals showing distinct advantages over current and other currently researched solutions.

COMPARATIVE EXAMINATION OF TERMS OF TURKISH ARMY ORGANIZATION IN MUHÂKEMETÜ’L-LÜGATEYN MUHÂKEMETÜ’L-LÜGATEYN’DEKİ TÜRK ORDU TEŞKİLATINA AİT TERİMLERİN KARŞILAŞTIRMALI İNCELEMESİ

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Oktay BERBER

2010-07-01

Full Text Available In his work called Muhâkemetü’l-Lügateyn prepared with the goal of proving the superiority of Turkish to Farsi, Ali Şîr Nevâyî has conveyed the language particularities of Turkish via showing evidences. Viewed from this angle, it’s a kind of grammer book, and another important aspect, contained valuable informations about Turkish culture. Because Nevâyî uses a lot of terms blended within the social, cultural, economic and political life of Turks while listing the evidences serving his purpose to edit this work. In our study, starting with these terms employed annotatively by Ali Şîr Nevâyî, eighteen concepts included within Turkish army organization and equivalents of these concepts in the antecedent and subsequent periods shall be included Ali Şîr Nevâyî, Türkçenin Farsçaya üstünlüğünü ispatlamak gayesiyle hazırladığı Muhâkemetü’l-Lügateyn adlı eserinde, Türkçeye ait dil hususiyetlerini deliller göstererek aktarmıştır. Bu açıdan bir çeşit dil bilgisi kitabı olarak önem arz eden eserin, bir başka önemli yanı, Türk kültürü hakkında değerli bilgileri içermesidir. Çünkü Nevâyî, eseri hazırlama amacına hizmet eden delilleri sıralarken, Türklerin sosyal, kültürel, ekonomik ve siyasal yaşantısı içerisinde harmanlanmış pek çok terimi kullanmıştır. Çalışmamızda Ali Şîr Nevâyî’nin açıklamalı olarak kullandığı bu terimlerden yola çıkarak, Türk ordu teşkilatı içerisinde yer alan on sekiz kavrama ve bu kavramların daha önceki ve sonraki dönemlerdeki karşılıklarına yer verilecektir.

Yeni Harflerin Kabulü Ve Adana Basını’na Yansıması: “Yeni Adana” ve “Türk Sözü” Gazetesi The Acceptance Of New Letters And Reflection Of Them To The Adana Press: “Yeni Adana” And “Türk Sözü”

Directory of Open Access Journals (Sweden)

Şeyda ÖZÇELİK

2013-09-01

Full Text Available The reflection of social, political, cultural, economic and religious developments in a country has been by the media like television, radio, newspaper and magazine. The role of the media in the years of liberation and foundation of Turkish Republic was also very important.Especially the newspapers provided psychological support to the publicin the time of the National Struggle played an active role instrengthening the national feelings, strengthening the unity andsolidarity. The local press as well as the national press informed thepeople of the region and got the people to become conscious about theNational Struggle during the War of Independence. The political andcultural vision of the new regime of Turkish Republic established afterthe War of Independence was involved in national and local mediamoment by moment. The changes and the transformations afterfoundation of state were delivered to the public through the press. Atthis stage, to be understood of Atatürk’s revolutions which were thehistoric moment for the Turkish Republic in becoming contemporarysociety was entrusted a major task of the press. It was the newspapersof the period which was one of the institutions working actively in theannouncement stage of the Letter Revolution one of the revolutions ofAtatürk. The introduction of new letters, the teaching to the public, theopinions of Mustafa Kemal and intellectuals about Latin letters oftenwere been involved in the press. In the study it will benefit from thefunctions of Yeni Adana established in 1918 and was the local media ofAdana and Türk Sözü began broadcasting in 1923. It will be exposedthe announcing of Letter Revolution, introducing of new letters and theroles in the process of implementation of these newspapers. Bir ülkedeki toplumsal, siyasal, kültürel, ekonomik ve dini gelişmelerin halka yansıması televizyon, radyo, gazete, dergi gibi basın yayın araçlarıyla olmuştur. Türkiye Cumhuriyeti Devleti�

Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.

Science.gov (United States)

Jin, Lily L; Wybenga-Groot, Leanne E; Tong, Jiefei; Taylor, Paul; Minden, Mark D; Trudel, Suzanne; McGlade, C Jane; Moran, Michael F

2015-03-01

Src homology 2 (SH2) domains are modular protein structures that bind phosphotyrosine (pY)-containing polypeptides and regulate cellular functions through protein-protein interactions. Proteomics analysis showed that the SH2 domains of Src family kinases are themselves tyrosine phosphorylated in blood system cancers, including acute myeloid leukemia, chronic lymphocytic leukemia, and multiple myeloma. Using the Src family kinase Lyn SH2 domain as a model, we found that phosphorylation at the conserved SH2 domain residue Y(194) impacts the affinity and specificity of SH2 domain binding to pY-containing peptides and proteins. Analysis of the Lyn SH2 domain crystal structure supports a model wherein phosphorylation of Y(194) on the EF loop modulates the binding pocket that engages amino acid side chains at the pY+2/+3 position. These data indicate another level of regulation wherein SH2-mediated protein-protein interactions are modulated by SH2 kinases and phosphatases. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

DEFF Research Database (Denmark)

Krintel, Christian; Frydenvang, Karla; Olsen, Lars

2012-01-01

Positive allosteric modulators of the ionotropic glutamate receptor-2 (GluA2) are promising compounds for the treatment of cognitive disorders, e.g. Alzheimer's disease. These modulators bind within the dimer interface of the ligand-binding domain and stabilize the agonist-bound conformation slow...

Molecular and applied modulation effects in electron-electron double resonance. 7. Modulation frequency effects for the CH/sub 2/COO/sup -/ radical in irradiated zinc acetate

Energy Technology Data Exchange (ETDEWEB)

Perkins, Jr, R C; Dalton, L R [Vanderbilt Univ., Nashville, Tenn. (USA). Dept. of Chemistry; Kispert, L D

1977-04-01

Frequency-swept absorption ELDOR signals for the CH/sub 2/COO/sup -/radical in zinc acetate depend upon Zeeman modulation frequency, the signals going from a positive to a negative sense as the Zeeman modulation frequency is varied from 100 to 1 kHz. A mathematical formulation derived explicitly considering applied electromagnetic radiation and Zeeman modulation fields is employed to computer-simulate the experimentally observed effects.

Improvement of the NSSS T/H Module for Enhancing the Simulation Fidelity of KNPEC-2 Simulator

International Nuclear Information System (INIS)

Kim, Kyung Doo; Lee, Seung Wook; Jeong, Jae Jun; Lee, Myung Soo

2005-01-01

KEPRI(Korea Electric Power Research Institute) and KAERI (Korea Atomic Energy Research Institute) jointly developed and supplied a realistic NSSS (Nuclear Steam Supply System) T/H (Thermal-Hydraulic) module (named ARTS) based on the best-estimate code RETRAN-3D for the improvement of the KNPEC-2 full-scope simulator in 2001. Although ARTS can simulate the most transients in real-time, and its robustness is ensured, real-time calculation and robustness can fail for largebreak (LB) loss-of-coolant accident (LOCA) and longterm, two-phase transients. In order to improve its robustness, ARTS equipped with the backup calculation module to be used whenever a regular ARTS module fails to calculate. When the symptom for the failure of T/H module is detected, the main ARTS module is replaced with the backup module for the calculation of primary and secondary reactor system although most failures of ARTS occur in the calculation of the primary system especially for LB LOCA simulation. The sudden transition from the main ARTS module to the backup module can exhibit the discontinuity of simulation of secondary system on rare occasions. To mitigate the simulation discontinuity, we have improved the backup module of ARTS. The performance of a new approach has been illustrated by the non-integrated standalone test. The improved ARTS module will be incorporated into KNPEC-2 simulator and evaluated its performance in the real simulator environment. This paper presents the brief description of a new backup calculation strategy and the simulation results of LOCA to evaluate the performance of a new backup strategy in standalone test environment

Effects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalization.

Directory of Open Access Journals (Sweden)

Dipannita Basu

Full Text Available The activity of G protein-coupled receptors (GPCRs is intricately regulated by a range of intracellular proteins, including G protein-coupled kinases (GRKs and arrestins. Understanding the effects of ligands on these signaling pathways could provide insights into disease pathophysiologies and treatment. The dopamine D2 receptor is a GPCR strongly implicated in the pathophysiology of a range of neurological and neuropsychiatric disorders, particularly schizophrenia. Previous studies from our lab have shown the preclinical efficacy of a novel allosteric drug, 3(R-[(2(S-pyrrolidinylcarbonylamino]-2-oxo-1-pyrrolidineacetamide (PAOPA, in attenuating schizophrenia-like behavioural abnormalities in rodent models of the disease. As an allosteric modulator, PAOPA binds to a site on the D2 receptor, which is distinct from the endogenous ligand-binding site, in order to modulate the binding of the D2 receptor ligand, dopamine. The exact signaling pathways affected by this allosteric modulator are currently unknown. The objectives of this study were to decipher the in vivo effects, in rats, of chronic PAOPA administration on D2 receptor regulatory and downstream molecules, including GRK2, arrestin-3 and extracellular receptor kinase (ERK 1/2. Additionally, an in vitro cellular model was also used to study PAOPA's effects on D2 receptor internalization. Results from western immunoblots showed that chronic PAOPA treatment increased the striatal expression of GRK2 by 41%, arrestin-3 by 34%, phospho-ERK1 by 51% and phospho-ERK2 by 36%. Results also showed that the addition of PAOPA to agonist treatment in cells increased D2 receptor internalization by 33%. This study provides the foundational evidence of putative signaling pathways, and changes in receptor localization, affected by treatment with PAOPA. It improves our understanding on the diverse mechanisms of action of allosteric modulators, while advancing PAOPA's development into a novel drug for the

Strut fracture with Björk-Shiley 70 degrees convexo-concave valve. An international multi-institutional follow-up study.

Science.gov (United States)

Ericsson, A; Lindblom, D; Semb, G; Huysmans, H A; Thulin, L I; Scully, H E; Bennett, J G; Ostermeyer, J; Grunkemeier, G L

1992-01-01

Between 1980 and 1983, 831 Björk-Shiley 70 degrees convexo-concave prosthetic heart valves were implanted at five institutions in Sweden, Germany. The Netherlands, and Canada. As of January 1991, there were 34 outlet strut fractures occurring from 0.2 to 10.1 years (median = 4.6 years) after implantation. In addition, there were 28 sudden, unexplained deaths. The mortality after strut fracture was 84%. The mortality after emergency valve replacement for strut fracture was 50%. The 10-year actuarial fracture rate (standard error) was 10.5 (2.4)% for large (29-33 mm) valves vs. 3.3 (1.2)% for 21-27 mm valves (P less than 0.001). Within valve size groups, fracture rates for aortic and mitral valves were similar. Cox regression analysis found only valve size to be significantly associated with strut fracture. There is a further subgrouping of the valves according to the manufacturer: group I are the earlier large 29-33 mm) valves; group II are the later large valves; group III are the small size (21-27 mm) valves. The risk of strut fracture was highest in group I (12.3% at 10 years) with an approximatively constant hazard (1.4% per year). A comparison was made with a statistical model incorporating all cases reported to the manufacturer. This model estimates fracture rates approximately 63%-73% of those found in the present study. These findings lead us to recommend that group I patients should be considered for elective reoperation on an individual basis, giving careful attention to risk factors and contraindications.

General Conformity Training Module 2.5: Proactive Role for Federal Agencies

Science.gov (United States)

Module 2.5 explains how taking a proactive role will allow a federal agency to more effectively participate in newly promulgated programs under the General Conformity Regulations, such as the emission reduction credits and the emission budgets programs.

Criticality classification of waste receiving and processing module 2A

International Nuclear Information System (INIS)

Boothe, G.F.

1994-10-01

The purpose of this document is to evaluate the criticality potential of the Waste Receiving and Processing Module 2A (WRAP 2A) and to demonstrate that the facility is an exempt facility, under the provisions of the Nuclear Criticality Safety Manual. The WRAP 2A maximum potential transuranic (TRU) contents of feedstreams and product inventories are discussed. Total plant fissionable materials are estimated and compared with the fissionable material exempt quantity. The WRAP 2A operations and processes are also described, relative to the potential for concentrating or accumulating fissionable material within the facility

Modulated anharmonic ADPs are intrinsic to aperiodic crystals: a case study on incommensurate Rb2ZnCl4

International Nuclear Information System (INIS)

Li, Liang; Wölfel, Alexander; Schönleber, Andreas; Mondal, Swastik; Schreurs, Antoine M. M.; Kroon-Batenburg, Loes M. J.; Smaalen, Sander van

2011-01-01

The superspace maximum entropy method (MEM) density in combination with structure refinements has been used to uncover the modulation in incommensurate Rb 2 ZnCl 4 close to the lock-in transition. Modulated atomic displacement parameters (ADPs) and modulated anharmonic ADPs are found to form an intrinsic part of the modulation. Refined values for the displacement modulation function depend on the presence or absence of modulated ADPs in the model. A combination of structure refinements, analysis of the superspace MEM density and interpretation of difference-Fourier maps has been used to characterize the incommensurate modulation of rubidium tetrachlorozincate, Rb 2 ZnCl 4 , at a temperature of T = 196 K, close to the lock-in transition at T lock-in = 192 K. The modulation is found to consist of a combination of displacement modulation functions, modulated atomic displacement parameters (ADPs) and modulated third-order anharmonic ADPs. Up to fifth-order Fourier coefficients could be refined against diffraction data containing up to fifth-order satellite reflections. The center-of-charge of the atomic basins of the MEM density and the displacive modulation functions of the structure model provide equivalent descriptions of the displacive modulation. Modulations of the ADPs and anharmonic ADPs are visible in the MEM density, but extracting quantitative information about these modulations appears to be difficult. In the structure refinements the modulation parameters of the ADPs form a dependent set, and ad hoc restrictions had to be introduced in the refinements. It is suggested that modulated harmonic ADPs and modulated third-order anharmonic ADPs form an intrinsic part, however small, of incommensurately modulated structures in general. Refinements of alternate models with and without parameters for modulated ADPs lead to significant differences between the parameters of the displacement modulation in these two types of models, thus showing the modulation of ADPs to

A RESEARCH ON THE ACADEMIC STUDIES ABOUT TURKISH LANGUAGE AND LITERATURE TEACHING TÜRK DİLİ VE EDEBİYATI ÖĞRETİMİNE YÖNELİK YAPILAN AKADEMİK ÇALIŞMALAR ÜZERİNE BİR İNCELEME

Directory of Open Access Journals (Sweden)

Serap UZUNER YURT

2012-01-01

Full Text Available The aim of this study is to reveal the general tendency of academic studies about Turkish Language and Literature teaching. In this study, the subject areas of the studies, their methods, universe and samples, and the obtained results and suggestions were analyzed. The study was done with screening model which is a descriptive research approach. The sample of the study consists of articles in 20 refereed journal of Turkey published in last 11 years (200-2010 and can be reached on internet. 34 of these articles related to the subject were analyzed in our study. In the result of the study, it was concluded that 23.5% of the analyzed articles were directly about Turkish Language and Literature teaching and education. it was found in 88.2% of the articles that the method was not indicated. No sample was chosen in 72.2% of them. In the related studies the most preferred universe sample group was preservice Turkish Language and Literature teachers. As a result of the study, it was found that the number of the studies about Turkish Language and Literature was not sufficient therefore, it was suggested to the researchers that they should do more studies to cope with the problems related to this area and fill the deficiency. Bu araştırmanın amacı, Türk dili ve edebiyatı öğretimi ile ilgili yapılan akademik çalışmaların genel eğilimlerini ortaya koymaktır. Araştırma kapsamında çalışmaların konu alanları, yöntemleri, evren ve örneklemleri ile araştırmalarda ulaşılan sonuçlar ve öneriler analiz edilmiştir. Araştırma, betimsel bir araştırma yaklaşımı olan tarama modelinde yapılmıştır. Araştırmanın örneklemini, son on bir yılda (2000-2010 elektronik ortamda ulaşılabilen Türkiye adresli 20 hakemli dergideki makaleler oluşturmaktadır. Bunlar arasından konu ile ilgili olan 34 makale araştırma kapsamında analize tabi tutulmuştur. Araştırma sonucunda incelenen makalelerin % 23.5’inin doğrudan Türk

Development of measurement device for evaluation of solar cell module output. 2; Taiyo denchi module shutsuryoku hyokayo sokuteiki no kaihatsu. 2

Energy Technology Data Exchange (ETDEWEB)

Minoda, M.; Itsumi, J. [Kumamoto Institute of Technology, Kumamoto (Japan)

1996-10-27

Enhancement in design efficiency may be attained as well as utilization in maintenance if on-the-spot data is made available, for the purpose of flexibly dealing with changes in design or matching with a house structure, in calculating the power generation output of a solar cell (PV) module. Under the circumstances, a small-sized compound measuring device was produced as a prototype which, using an I-V curve tracer, measured output and condition of a roof at the time of installation, compared with the optimum operation and predicted the power generation. The device was structured with the main body consisting of a computing part, measurement controller and power supply and with various sensor modules. The electron load control method was employed in order to measure I-V characteristics of the PV module, since it was desirable to use a variable load and to cover the range from the release voltage of a solar cell to the short-circuit state through the maximum output point. The reference module method was used for the system evaluation. The device was presumably applicable to a PV system design by incorporating a sensor module for measuring design environment data, which was essential at the time of a system design, in addition to those for measuring output. 9 refs., 4 figs., 3 tabs.

Post-translational regulation of P2X receptor channels: modulation by phospholipids

Directory of Open Access Journals (Sweden)

Louis-Philippe eBernier

2013-11-01

Full Text Available P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response. P2X receptors constitute a gene family of calcium-permeable ATP-gated cation channels therefore the regulation of P2X signaling is critical for both membrane potential and intracellular calcium homeostasis. Phosphoinositides (PIPn are anionic signaling phospholipids that act as functional regulators of many types of ion channels. Direct PIPn binding was demonstrated for several ligand- or voltage-gated ion channels, however no generic motif emerged to accurately predict lipid-protein binding sites. This review presents what is currently known about the modulation of the different P2X subtypes by phospholipids and about critical determinants underlying their sensitivity to PIPn levels in the plasma membrane.All functional mammalian P2X subtypes tested, with the notable exception of P2X5, have been shown to be positively modulated by PIPn, i.e. homomeric P2X1, P2X2, P2X3, P2X4, and P2X7, as well as heteromeric P2X1/5 and P2X2/3 receptors. Based on various results reported on the aforementioned subtypes including mutagenesis of the prototypical PIPn-sensitive P2X4 and PIPn-insensitive P2X5 receptor subtypes, an increasing amount of functional, biochemical and structural evidence converges on the modulatory role of a short polybasic domain located in the proximal C-terminus of P2X subunits. This linear motif, semi-conserved in the P2X family, seems necessary and sufficient for encoding direct modulation of ATP-gated channels by PIPn. Furthermore, the physiological impact of the regulation of ionotropic purinergic responses by phospholipids on pain pathways was recently revealed in the context of native crosstalks between phospholipase C-linked metabotropic receptors and P2X receptor channels in DRG sensory neurons and microglia.

Thin-film VO2 submillimeter-wave modulators and polarizers

International Nuclear Information System (INIS)

Fan, J.C.C.; Fetterman, H.R.; Bachner, F.J.; Zavracky, P.M.; Parker, C.D.

1977-01-01

Submillimeter-wave modulators and switchable polarizers have been fabricated from VO 2 thin films deposited on sapphire substrates. By passing electric current pulses through elements made from these films, the films can be thermally cycled through the insulator-to-metal transition that occurs in VO 2 at about 65 degreeC. In the insulating state, the films are found to have negligible effect on the transmission at submillimeter wavelengths, while above the phase transition the transmission is strongly reduced by the free-electron effects characteristic of a metal. Other possible applications of such switchable VO 2 elements include variable bandpass filters and diffraction grating beam-steering devices

Shahat et al., Afr J Tradit Complement Altern Med. (2017) 14(2):161 ...

African Journals Online (AJOL)

Sayed

extracts, Serratia marcescens displayed inhibition zone ranged between 10-17 mm. The antimicrobial activity of plant extracts against bacteria was more effective than against fungi, which is similar to the results reported by Avato and Ertürk (Avato et al.,. 1997; Ertürk et al., 2003). Acknowledgments. The authors extend their ...

NO2 inhalation promotes Alzheimer’s disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication

Science.gov (United States)

Yan, Wei; Yun, Yang; Ku, Tingting; Li, Guangke; Sang, Nan

2016-03-01

Air pollution has been reported to be associated with increased risks of cognitive impairment and neurodegenerative diseases. Because NO2 is a typical primary air pollutant and an important contributor to secondary aerosols, NO2-induced neuronal functional abnormalities have attracted greater attention, but the available experimental evidence, modulating mechanisms, and targeting medications remain ambiguous. In this study, we exposed C57BL/6J and APP/PS1 mice to dynamic NO2 inhalation and found for the first time that NO2 inhalation caused deterioration of spatial learning and memory, aggravated amyloid β42 (Aβ42) accumulation, and promoted pathological abnormalities and cognitive defects related to Alzheimer’s disease (AD). The microarray and bioinformation data showed that the cyclooxygenase-2 (COX-2)-mediated arachidonic acid (AA) metabolism of prostaglandin E2 (PGE2) played a key role in modulating this aggravation. Furthermore, increasing endocannabinoid 2-arachidonoylglycerol (2-AG) by inhibiting monoacylglycerol lipase (MAGL) prevented PGE2 production, neuroinflammation-associated Aβ42 accumulation, and neurodegeneration, indicating a therapeutic target for relieving cognitive impairment caused by NO2 exposure.

Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics

Energy Technology Data Exchange (ETDEWEB)

Tocchetti, Guillermo Nicolás [Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Suipacha 570, 2000 Rosario (Argentina); Rigalli, Juan Pablo [Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Suipacha 570, 2000 Rosario (Argentina); Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg (Germany); Arana, Maite Rocío; Villanueva, Silvina Stella Maris [Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Suipacha 570, 2000 Rosario (Argentina); Mottino, Aldo Domingo, E-mail: amottino@unr.edu.ar [Instituto de Fisiología Experimental, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Suipacha 570, 2000 Rosario (Argentina)

2016-07-15

The multidrug resistance-associated protein 2 (MRP2/ABCC2) is a transporter that belongs to the ATP-binding cassette (ABC) superfamily. In the intestine, it is localized to the apical membrane of the enterocyte and plays a key role in limiting the absorption of xenobiotics incorporated orally. MRP2 may also play a role in systemic clearance of xenobiotics available from the serosal side of the intestine. MRP2 transports a wide range of substrates, mainly organic anions conjugated with glucuronic acid, glutathione and sulfate and its expression can be modulated by xenobiotics at transcriptional- and post-transcriptional levels. Transcriptional regulation is usually mediated by a group of nuclear receptors. The pregnane X receptor (PXR) is a major member of this group. Relevant drugs described to up-regulate intestinal MRP2 via PXR are rifampicin, spironolactone and carbamazepine, among others. The constitutive androstane receptor (CAR, NR1I3) was also reported to modulate MRP2 expression, phenobarbital being a typical activator. Dietary compounds, including micronutrients and other natural products, are also capable of regulating intestinal MRP2 expression transcriptionally. We have given them particular attention since the composition of the food ingested daily is not necessarily supervised and may result in interactions with therapeutic drugs. Post-transcriptional regulation of MRP2 activity by xenobiotics, e.g. as a consequence of inhibitory actions, is also described in this review. Unfortunately, only few studies report on drug-drug or nutrient-drug interactions as a consequence of modulation of intestinal MRP2 activity by xenobiotics. Future clinical studies are expected to identify additional interactions resulting in changes in efficacy or safety of therapeutic drugs. - Highlights: • Intestinal MRP2 (ABCC2) expression and activity can be regulated by xenobiotics. • PXR and CAR are major MRP2 modulators through a transcriptional mechanism. • Rifampicin

Module-theoretic properties of reachability modules for SRIQ

CSIR Research Space (South Africa)

Nortje, R

2013-07-01

Full Text Available ]. Definition 1. (Module for the arbitrary DL L) Let L be an arbitrary de- scription language, O an L ontology, and σ a statement formulated in L. Then, 2 O′ ⊆ O is a module for σ in O(a σ-module in O) whenever: O |= σ if and only if O′ |= σ. Definition 1... > 1, a SRIQ TBox T is in normal form if every axiom α ∈ T is in one of the following forms: α1: B1 u . . . uBn v C1 unionsq . . . unionsq Cm α2: D v C1 unionsq . . . unionsq Cm α3: B1 u . . . uBn v D α4: R1 ◦ . . . ◦Rn v Rn+1 α5: R1 v R2 α6: D1 v D2 α7...

Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype

International Nuclear Information System (INIS)

Wilson, A.L.; Seibert, K.; Brandon, S.; Cragoe, E.J. Jr.; Limbird, L.E.

1991-01-01

The unglycosylated alpha 2B subtype of the alpha 2-adrenergic receptor found in NG-108-15 cells possesses allosteric regulation of adrenergic ligand binding by monovalent cations and 5-amino-substituted amiloride analogs. These findings demonstrate that allosteric modulation of adrenergic ligand binding is not a property unique to the alpha 2A subtype. The observation that amiloride analogs as well as monovalent cations can modulate adrenergic ligand binding to the nonglycosylated alpha 2B subtype indicates that charge shielding due to carbohydrate moieties does not play a role in this allosteric modulation but, rather, these regulatory effects result from interactions of cations and amiloride analogs with the protein moiety of the receptor. Furthermore, the observation that both alpha 2A and alpha 2B receptor subtypes are modulated by amiloride analogs suggests that structural domains that are conserved between the two are likely to be involved in this allosteric modulation

Cervical cancer cell lines expressing NKG2D-ligands are able to down-modulate the NKG2D receptor on NKL cells with functional implications

Directory of Open Access Journals (Sweden)

Jimenez-Perez Miriam I

2012-02-01

Full Text Available Abstract Background Cervical cancer represents the third most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women worldwide. Natural killer (NK cells play an important role in the defense against viruses, intracellular bacteria and tumors. NKG2D, an activating receptor on NK cells, recognizes MHC class I chain-related molecules, such as MICA/B and members of the ULBP/RAET1 family. Tumor-derived soluble NKG2D-ligands have been shown to down-modulate the expression of NKG2D on NK cells. In addition to the down-modulation induced by soluble NKG2D-ligands, it has recently been described that persistent cell-cell contact can also down-modulate NKG2D expression. The goal of this study was to determine whether the NKG2D receptor is down-modulated by cell-cell contact with cervical cancer cells and whether this down-modulation might be associated with changes in NK cell activity. Results We demonstrate that NKG2D expressed on NKL cells is down-modulated by direct cell contact with cervical cancer cell lines HeLa, SiHa, and C33A, but not with non-tumorigenic keratinocytes (HaCaT. Moreover, this down-modulation had functional implications. We found expression of NKG2D-ligands in all cervical cancer cell lines, but the patterns of ligand distribution were different in each cell line. Cervical cancer cell lines co-cultured with NKL cells or fresh NK cells induced a marked diminution of NKG2D expression on NKL cells. Additionally, the cytotoxic activity of NKL cells against K562 targets was compromised after co-culture with HeLa and SiHa cells, while co-culture with C33A increased the cytotoxic activity of the NKL cells. Conclusions Our results suggest that differential expression of NKG2D-ligands in cervical cancer cell lines might be associated with the down-modulation of NKG2D, as well as with changes in the cytotoxic activity of NKL cells after cell-cell contact with the tumor cells.

Kinetic modeling of sporulation and product formation in stationary phase by Bacillus coagulans RK-02 vis-à-vis other Bacilli.

Science.gov (United States)

Das, Subhasish; Sen, Ramkrishna

2011-10-01

A logistic kinetic model was derived and validated to characterize the dynamics of a sporogenous bacterium in stationary phase with respect to sporulation and product formation. The kinetic constants as determined using this model are particularly important for describing intrinsic properties of a sporogenous bacterial culture in stationary phase. Non-linear curve fitting of the experimental data into the mathematical model showed very good correlation with the predicted values for sporulation and lipase production by Bacillus coagulans RK-02 culture in minimal media. Model fitting of literature data of sporulation and product (protease and amylase) formation in the stationary phase by some other Bacilli and comparison of the results of model fitting with those of Bacillus coagulans helped validate the significance and robustness of the developed kinetic model. Copyright © 2011 Elsevier Ltd. All rights reserved.

İşitme engelli okuyucuların okuma sürecinde Türkçenin ve Türk İşaret dilinin biçim-sözdizim özellikleri

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Necla Işıkdoğan Uğurlu

2017-07-01

Full Text Available İşitme engelli okuyucuların bir metni bütünüyle kavrayabilmesi için biçimbirimsel ve biçim-sözdizimsel farkındalık becerilerinin gelişmesi gerekmektedir. En küçük birimleri inceleyen biçimbilim sadece birimleri değil, metnin tümünün kavranmasını hedeflemektedir. Kısacası biçimbirimsel ve biçim-sözdizimsel becerilerde öğrencilerin sahip oldukları farkındalığın, onların sesbilim, sözdizim, anlambilim gibi diğer dil bileşenlerine ilişkin becerilerde de farkındalık sağlamaktadır. Günümüzde okuma becerilerini kazanmada, dil bileşenlerini kapsayan biçimbirimsel ve biçim-sözdizimsel farkındalık becerilerinin önemi giderek daha fazla sayıda vurgulanmaktadır. İşitme engelli okuyucuların işaret dili yeterliği ile okuma yazma becerilerinin kazanımı arasında pozitif bir ilişki olmakla birlikte her iki dilin de kendi dilbilimsel kurallarının olduğu ve okuryazarlık becerilerinin kazanılmasında diller arası olumlu bir etkileşimin olduğu bilinmektedir. Bu nedenle de işaret dili yeterliliği ile okuma yazma becerileri arasındaki bu olumlu etkileşimden yola çıkarak her iki dilin biçim-sözdizimsel özelliklerinin öğrenilerek işitme engelli çocukların okuma yazma becerilerinin kazanımında etkili kullanımına yer verilmelidir. Bu derlemede, okuma becerilerinde Türk İşaret Dili (TİD ve Türkçe olmak üzere her iki dilin biçimbilimsel ve biçim-sözdizimsel özellikleri eylemlerde uyum ve zaman kategorileri açısından karşılaştırmalı olarak incelenmektedir. To be able to understand a text entirely, person second language need to develop both their morphemic and morpho-syntactic awareness. Morphology-which involves the evaluation of the smallest components-aims to ensure not only the understanding of individual components, but also the entire text. Students’ awareness and knowledge of morphemic and morpho-syntactic skills positively affect their awareness and

Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation

International Nuclear Information System (INIS)

Rodriguez, J.B.R.; Muzi-Filho, H.; Valverde, R.H.F.; Quintas, L.E.M.; Noel, F.; Einicker-Lamas, M.; Cunha, V.M.N.

2013-01-01

Ca 2+ pumps are important players in smooth muscle contraction. Nevertheless, little information is available about these pumps in the vas deferens. We have determined which subtype of sarco(endo)plasmic reticulum Ca 2+ -ATPase isoform (SERCA) is expressed in rat vas deferens (RVD) and its modulation by calmodulin (CaM)-dependent mechanisms. The thapsigargin-sensitive Ca 2+ -ATPase from a membrane fraction containing the highest SERCA levels in the RVD homogenate has the same molecular mass (∼115 kDa) as that of SERCA2 from the rat cerebellum. It has a very high affinity for Ca 2+ (Ca 0.5 = 780 nM) and a low sensitivity to vanadate (IC 50 = 41 µM). These facts indicate that SERCA2 is present in the RVD. Immunoblotting for CaM and Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) showed the expression of these two regulatory proteins. Ca 2+ and CaM increased serine-phosphorylated residues of the 115-kDa protein, indicating the involvement of CaMKII in the regulatory phosphorylation of SERCA2. Phosphorylation is accompanied by an 8-fold increase of thapsigargin-sensitive Ca 2+ accumulation in the lumen of vesicles derived from these membranes. These data establish that SERCA2 in the RVD is modulated by Ca 2+ and CaM, possibly via CaMKII, in a process that results in stimulation of Ca 2+ pumping activity

Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA Receptor Currents.

Science.gov (United States)

Chowdhury, Luvana; Croft, Celine J; Goel, Shikha; Zaman, Naina; Tai, Angela C-S; Walch, Erin M; Smith, Kelly; Page, Alexandra; Shea, Kevin M; Hall, C Dennis; Jishkariani, D; Pillai, Girinath G; Hall, Adam C

2016-06-01

GABAA receptors meet all of the pharmacological requirements necessary to be considered important targets for the action of general anesthetic agents in the mammalian brain. In the following patch-clamp study, the relative modulatory effects of 2,6-dimethylcyclohexanol diastereomers were investigated on human GABAA (α1β3γ2s) receptor currents stably expressed in human embryonic kidney cells. Cis,cis-, trans,trans-, and cis,trans-isomers were isolated from commercially available 2,6-dimethylcyclohexanol and were tested for positive modulation of submaximal GABA responses. For example, the addition of 30 μM cis,cis-isomer resulted in an approximately 2- to 3-fold enhancement of the EC20 GABA current. Coapplications of 30 μM 2,6-dimethylcyclohexanol isomers produced a range of positive enhancements of control GABA responses with a rank order for positive modulation: cis,cis > trans,trans ≥ mixture of isomers > > cis,trans-isomer. In molecular modeling studies, the three cyclohexanol isomers bound with the highest binding energies to a pocket within transmembrane helices M1 and M2 of the β3 subunit through hydrogen-bonding interactions with a glutamine at the 224 position and a tyrosine at the 220 position. The energies for binding to and hydrogen-bond lengths within this pocket corresponded with the relative potencies of the agents for positive modulation of GABAA receptor currents (cis,cis > trans,trans > cis,trans-2,6-dimethylcyclohexanol). In conclusion, the stereochemical configuration within the dimethylcyclohexanols is an important molecular feature in conferring positive modulation of GABAA receptor activity and for binding to the receptor, a consideration that needs to be taken into account when designing novel anesthetics with enhanced therapeutic indices. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

System tests with silicon strip module prototypes for the Phase-2-upgrade of the CMS tracker

Energy Technology Data Exchange (ETDEWEB)

Feld, Lutz; Karpinski, Waclaw; Klein, Katja; Preuten, Marius [I. Physikalisches Institut B, RWTH Aachen University (Germany)

2016-07-01

To prepare the CMS experiment for the High Luminosity LHC and its instantaneous luminosity of 5 . 10{sup 34} cm{sup -2}s{sup -1}, in the Long Shutdown 3 (around 2024) the CMS Silicon Tracker will be replaced. The Silicon Strip Modules for the new Tracker will host two vertically stacked sensors. The combination of hit information from both sensors will allow the estimation of the transverse momentum (p{sub T}) of charged particles in the module front-end. This can be used to identify hits from potential interesting high-p{sub T} tracks (above 2 GeV) for the first trigger level. The CMS Binary Chip (CBC) provides the analogue readout of two sensors and a digital section, into which the momentum discrimination is integrated. The modules will host a new DC-DC converter chain, which will allow individual powering of each module. First measurements with early prototypes on the interplay between DC-DC powering and the read-out functions of the module are presented in this talk.

The core regulatory network of the abscisic acid pathway in banana: genome-wide identification and expression analyses during development, ripening, and abiotic stress.

Science.gov (United States)

Hu, Wei; Yan, Yan; Shi, Haitao; Liu, Juhua; Miao, Hongxia; Tie, Weiwei; Ding, Zehong; Ding, XuPo; Wu, Chunlai; Liu, Yang; Wang, Jiashui; Xu, Biyu; Jin, Zhiqiang

2017-08-29

Abscisic acid (ABA) signaling plays a crucial role in developmental and environmental adaptation processes of plants. However, the PYL-PP2C-SnRK2 families that function as the core components of ABA signaling are not well understood in banana. In the present study, 24 PYL, 87 PP2C, and 11 SnRK2 genes were identified from banana, which was further supported by evolutionary relationships, conserved motif and gene structure analyses. The comprehensive transcriptomic analyses showed that banana PYL-PP2C-SnRK2 genes are involved in tissue development, fruit development and ripening, and response to abiotic stress in two cultivated varieties. Moreover, comparative expression analyses of PYL-PP2C-SnRK2 genes between BaXi Jiao (BX) and Fen Jiao (FJ) revealed that PYL-PP2C-SnRK2-mediated ABA signaling might positively regulate banana fruit ripening and tolerance to cold, salt, and osmotic stresses. Finally, interaction networks and co-expression assays demonstrated that the core components of ABA signaling were more active in FJ than in BX in response to abiotic stress, further supporting the crucial role of the genes in tolerance to abiotic stress in banana. This study provides new insights into the complicated transcriptional control of PYL-PP2C-SnRK2 genes, improves the understanding of PYL-PP2C-SnRK2-mediated ABA signaling in the regulation of fruit development, ripening, and response to abiotic stress, and identifies some candidate genes for genetic improvement of banana.

Cholinergic Modulation of Type 2 Immune Responses

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Goele Bosmans

2017-12-01

Full Text Available In recent years, the bidirectional relationship between the nervous and immune system has become increasingly clear, and its role in both homeostasis and inflammation has been well documented over the years. Since the introduction of the cholinergic anti-inflammatory pathway, there has been an increased interest in parasympathetic regulation of both innate and adaptive immune responses, including T helper 2 responses. Increasing evidence has been emerging suggesting a role for the parasympathetic nervous system in the pathophysiology of allergic diseases, including allergic rhinitis, asthma, food allergy, and atopic dermatitis. In this review, we will highlight the role of cholinergic modulation by both nicotinic and muscarinic receptors in several key aspects of the allergic inflammatory response, including barrier function, innate and adaptive immune responses, and effector cells responses. A better understanding of these cholinergic processes mediating key aspects of type 2 immune disorders might lead to novel therapeutic approaches to treat allergic diseases.

Involvement of α2-adrenoceptors in inhibitory and facilitatory pain modulation processes.

Science.gov (United States)

Vo, L; Drummond, P D

2016-03-01

In healthy humans, high-frequency electrical stimulation (HFS) of the forearm not only produces hyperalgesia at the site of stimulation but also reduces sensitivity to pressure-pain on the ipsilateral side of the forehead. In addition, HFS augments the ipsilateral trigeminal nociceptive blink reflex and intensifies the ipsilateral component of conditioned pain modulation. The aim of this study was to determine whether α2-adrenoceptors mediate these ipsilateral nociceptive influences. The α2-adrenoceptor antagonist yohimbine was administered to 22 participants in a double-blind, placebo-controlled crossover study. In each session, thermal and mechanical sensitivity in the forearms and forehead was assessed before and after HFS. In addition, the combined effect of HFS and yohimbine on the nociceptive blink reflex and on conditioned pain modulation was explored. In this paradigm, the conditioning stimulus was cold pain in the ipsilateral or contralateral temple, and the test stimulus was electrically evoked pain in the forearm. Blood pressure and electrodermal activity increased for several hours after yohimbine administration, consistent with blockade of central α2-adrenoceptors. Yohimbine not only augmented the nociceptive blink reflex ipsilateral to HFS but also intensified the inhibitory influence of ipsilateral temple cooling on electrically evoked pain at the HFS-treated site in the forearm. Yohimbine had no consistent effect on primary or secondary hyperalgesia in the forearm or on pressure-pain in the ipsilateral forehead. These findings imply involvement of α2-adrenoceptors both in ipsilateral antinociceptive and pronociceptive pain modulation processes. However, a mechanism not involving α2-adrenoceptors appears to mediate analgesia in the ipsilateral forehead after HFS. © 2015 European Pain Federation - EFIC®

Graetzel solar cell modules for outdoor applications, phase 2. Final report; Graetzel-solcellsmoduler foer utomhusapplikationer, fas 2. Slutrapport

Energy Technology Data Exchange (ETDEWEB)

Pettersson, Henrik [IVF Industriforskning och utveckling AB, Moelndal (Sweden)

2005-06-01

The project 'Monolithic Dye PV Modules for Outdoor Applications' has been performed at IVF Industrial Research and Development Corporation in Moelndal over the period June 2003 to December 2004. The possibility of the dye-sensitised solar cell technology compared to other PV technologies is to realise PV products with low cost/W{sub peak} in combination with a low investment cost for setting up a production unit. The latter is important since it opens for production by smaller companies and reduces the risk related to commercialisation. The technical efforts of the project have resulted in monolithic dye PV cells with efficiencies up to 7 %. The module preparation has been scaled up to module sizes of 200 cm{sup 2} using industrial manufacturing methods. These devices will be further developed in 2005 in the project 'Flexible Solar Cells'.

Abscisic acid-activated SNRK2 protein kinases function in the gene-regulation pathway of ABA signal transduction by phosphorylating ABA response element-binding factors.

Science.gov (United States)

Kobayashi, Yuhko; Murata, Michiharu; Minami, Hideyuki; Yamamoto, Shuhei; Kagaya, Yasuaki; Hobo, Tokunori; Yamamoto, Akiko; Hattori, Tsukaho

2005-12-01

The plant hormone abscisic acid (ABA) induces gene expression via the ABA-response element (ABRE) present in the promoters of ABA-regulated genes. A group of bZIP proteins have been identified as ABRE-binding factors (ABFs) that activate transcription through this cis element. A rice ABF, TRAB1, has been shown to be activated via ABA-dependent phosphorylation. While a large number of signalling factors have been identified that are involved in stomatal regulation by ABA, relatively less is known about the ABA-signalling pathway that leads to gene expression. We have shown recently that three members of the rice SnRK2 protein kinase family, SAPK8, SAPK9 and SAPK10, are activated by ABA signal as well as by hyperosmotic stress. Here we show that transient overexpression in cultured cell protoplasts of these ABA-activated SnRK2 protein kinases leads to the activation of an ABRE-regulated promoter, suggesting that these kinases are involved in the gene-regulation pathway of ABA signalling. We further show several lines of evidence that these ABA-activated SnRK2 protein kinases directly phosphorylate TRAB1 in response to ABA. Kinetic analysis of SAPK10 activation and TRAB1 phosphorylation indicated that the latter immediately followed the former. TRAB1 was found to be phosphorylated not only in response to ABA, but also in response to hyperosmotic stress, which was interpreted as the consequence of phosphorylation of TRAB1 by hyperosmotically activated SAPKs. Physical interaction between TRAB1 and SAPK10 in vivo was demonstrated by a co-immunoprecipitation experiment. Finally, TRAB1 was phosphorylated in vitro by the ABA-activated SnRK2 protein kinases at Ser102, which is phosphorylated in vivo in response to ABA and is critical for the activation function.

3D PLUS HI-REL DDR2 Termination Regulator Module- A Building Block Function for High Reliability SDRAM DDR2 System Architecture

Science.gov (United States)

Perrot, Nicolas; Dubus, Patrick; Garcia-Sanchez, Esther

2015-09-01

Memory system architectures using DDR2 technology need to be compliant with JEDEC JESD8-15A standard [1]. Therefore a bus termination regulator able to sink and source current while regulating VTT voltage is used for this purpose. Such module has been developed by 3D PLUS and is the first space qualified DDR Termination Regulator (DDR2-TR) available on the market. It is based on an innovative Bang-Bang regulation principle, chosen for its speed performance and to guarantee an output voltage that remains within the predefined limits regardless of any output current transients. The output filter type is selected to make the module rugged to any overload condition without complex protection circuits. The module has been specifically designed for low input voltage, low noise and high reliability systems where space is a key consideration. The module uses the 3D PLUS SIP (System-In-Package) technology embedding 3 stacked PCBs. No external filters or decoupling capacitors are needed.

Anaerobic Digestion Analysis. Training Module 5.120.2.77.

Science.gov (United States)

Kirkwood Community Coll., Cedar Rapids, IA.

This document is an instructional module package prepared in objective form for use by an instructor familiar with alkalinity, volatile acids and carbon dioxide determinations for an anaerobic sludge digester. Included are objectives, instructor guides, student handouts and transparency masters. This module considers total and bicarbonate…

Atatürk ve Güzel Sanatlar

Directory of Open Access Journals (Sweden)

Nurgün Koç

2012-06-01

Full Text Available ÖzetBilindiği üzere Türkiye Cumhuriyeti’nin kurulmasından kısa süre sonra hemen hemen her alanı kapsayan bir reform süreci başlatılmıştır. Bu yenilik hareketleri sosyal, siyasal, ekonomik vb. alanlarda görüldüğü gibi kültürel konularda da karşımıza çıkmaktadır. Atatürk kültürün önemli unsurlarından biri olan güzel sanatlardaki gelişime çok önem vermiş ve teşvik etmiştir. Uygar ülkeler arasına girmenin güzel sanatlar alanındaki başarılara bağlı olduğunu belirtmiştir. Bu yüzden 1936 yılında Devlet Konservatuarı kurulmuş, sahne sanatları, resim, müzik, heykel v.b güzel sanatların her alanında sanatçıların yetişmesi sağlanmıştır. Bu arada geleneksel sanatlara da önem verilmiş fakat Batılılaşma sürecinin hızıyla biraz geri planda kalmışlardır.Abstract As known, soon after Turkish Republic was founded, a reform process covering almost all fields was launched. These reform movements are also seen in cultural issues as well as in social, political and economic fields. Ataturk attached great importance to the development in fine arts which is one of the important elements of the culture and encouraged it. He stated that entering into civilized countries is up to the achievements in the field of fine arts. Therefore, state conservatory was founded in 1936 and artists in all fields of fine arts like performing arts, painting, music, sculpture were raised. Meanwhile, traditional arts were also emphasized, but remained a bit in the background because of fast process of Westernization. RésuméComme on le sait, peu de temps après la fondation de la République de Turquie, le processus de réforme a été lancé dans presque tous les domaines. Ces mouvements d’innovation apparaissent dans les domaines culturels ainsi que dans les domaines sociaux, politiques et économiques. Atatürk a aussi accordé une grande importance au développement des beaux-arts qui sont un des �

Crossed modules of racks

OpenAIRE

Crans, Alissa S.; Wagemann, Friedrich

2014-01-01

We generalize the notion of a crossed module of groups to that of a crossed module of racks. We investigate the relation to categorified racks, namely strict 2-racks, and trunk-like objects in the category of racks, generalizing the relation between crossed modules of groups and strict 2-groups. Then we explore topological applications. We show that by applying the rack-space functor, a crossed module of racks gives rise to a covering. Our main result shows how the fundamental racks associate...

“Citation Style Language” Uygulaması: APA Kaynak Gösterme Biçiminin Türkçeye Adaptasyonu=“Citation Style Language” Application: The Adaptation of APA Style to Turkish Language

Directory of Open Access Journals (Sweden)

Kasım Binici

2013-10-01

Full Text Available Bibliyografya yönetim programları, araştırma metinlerin yazımında yazarlara büyük avantajlar sağlamaktadır.Akademik çevrede EndNote, RefWorks, Zotero, Mendeley en popüler yazılımlardır. Türkçe kaynak gösterme kurallarının tanımlı olduğu biçim dosyalarının olmaması nedeniyle araştırma metni yazımında bu programlar işlevsiz kalmaktadır. Bu çalışmada, APA kaynak gösterme biçiminin Türkçeye adaptasyonu sağlanarak CSL uygulaması ile biçim dosyasında kodlar yazılmıştır. Yeni biçim dosyası Zotero ve Mendeley programlarında çalışabilirliği test edilerek kişilerin kullanımına sunulmuştur. Çalışma neticesinde oluşturulan APA-TR dosyası sayesinde Türkçe araştırma metinlerinin yazımında CSL uygulamasını tercih eden bibli- yografya yönetim yazılımların kullanımı mümkün olmuştur./Bibliography managment tools provide great advantage for researchers with writing their articles or research papers. In academic environment, EndNote, RefWorks, Zotero, Mendeley are the most popular software programms. Due to the lack of style files in which citation rules in Turkish language are described,these softwares stay functionless. In this study by providing turkish adaptation of APA citation style, new codes were written into the style file via CSL application. New style file is presented to users after testing its workability in Zotero and Mendeley programms. Thanks to APA-TR style file created as a result of the study,it is possibble to use bibliography managment tools which prefer CSL application in writing research papers Turkish language.

Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O(2) uptake.

Science.gov (United States)

Carreras, M C; Peralta, J G; Converso, D P; Finocchietto, P V; Rebagliati, I; Zaninovich, A A; Poderoso, J J

2001-12-01

Changes in O(2) uptake at different thyroid status have been explained on the basis of the modulation of mitochondrial enzymes and membrane biophysical properties. Regarding the nitric oxide (NO) effects, we tested whether liver mitochondrial nitric oxide synthase (mtNOS) participates in the modulation of O(2) uptake in thyroid disorders. Wistar rats were inoculated with 400 microCi (131)I (hypothyroid group), 20 microg thyroxine (T(4))/100 g body wt administered daily for 2 wk (hyperthyroid group) or vehicle (control). Basal metabolic rate, mitochondrial function, and mtNOS activity were analyzed. Systemic and liver mitochondrial O(2) uptake and cytochrome oxidase activity were lower in hypothyroid rats with respect to controls; mitochondrial parameters were further decreased by L-arginine (-42 and -34%, P activity (260%) were selectively increased in hypothyroidism and reverted by hormone replacement without changes in other nitric oxide isoforms. Moreover, mtNOS activity correlated with serum 3,5,3'-triiodothyronine (T(3)) and O(2) uptake. Increased mtNOS activity was also observed in skeletal muscle mitochondria from hypothyroid rats. Therefore, we suggest that modulation of mtNOS is a substantial part of thyroid effects on mitochondrial O(2) uptake.

Crystal Structure of the FERM-SH2 Module of Human Jak2.

Science.gov (United States)

McNally, Randall; Toms, Angela V; Eck, Michael J

2016-01-01

Jak-family tyrosine kinases mediate signaling from diverse cytokine receptors. Binding of Jaks to their cognate receptors is mediated by their N-terminal region, which contains FERM and SH2 domains. Here we describe the crystal structure of the FERM-SH2 region of Jak2 at 3.0Å resolution. The structure reveals that these domains and their flanking linker segments interact intimately to form an integrated structural module. The Jak2 FERM-SH2 structure closely resembles that recently described for Tyk2, another member of the Jak family. While the overall architecture and interdomain orientations are preserved between Jak2 and Tyk2, we identify residues in the putative receptor-binding groove that differ between the two and may contribute to the specificity of receptor recognition. Analysis of Jak mutations that are reported to disrupt receptor binding reveals that they lie in the hydrophobic core of the FERM domain, and are thus expected to compromise the structural integrity of the FERM-SH2 unit. Similarly, analysis of mutations in Jak3 that are associated with severe combined immunodeficiency suggests that they compromise Jak3 function by destabilizing the FERM-SH2 structure.

Advanced Sine Wave Modulation of Continuous Wave Laser System for Atmospheric CO2 Differential Absorption Measurements

Science.gov (United States)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.

2014-01-01

NASA Langley Research Center in collaboration with ITT Exelis have been experimenting with Continuous Wave (CW) laser absorption spectrometer (LAS) as a means of performing atmospheric CO2 column measurements from space to support the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) mission.Because range resolving Intensity Modulated (IM) CW lidar techniques presented here rely on matched filter correlations, autocorrelation properties without side lobes or other artifacts are highly desirable since the autocorrelation function is critical for the measurements of lidar return powers, laser path lengths, and CO2 column amounts. In this paper modulation techniques are investigated that improve autocorrelation properties. The modulation techniques investigated in this paper include sine waves modulated by maximum length (ML) sequences in various hardware configurations. A CW lidar system using sine waves modulated by ML pseudo random noise codes is described, which uses a time shifting approach to separate channels and make multiple, simultaneous online/offline differential absorption measurements. Unlike the pure ML sequence, this technique is useful in hardware that is band pass filtered as the IM sine wave carrier shifts the main power band. Both amplitude and Phase Shift Keying (PSK) modulated IM carriers are investigated that exibit perfect autocorrelation properties down to one cycle per code bit. In addition, a method is presented to bandwidth limit the ML sequence based on a Gaussian filter implemented in terms of Jacobi theta functions that does not seriously degrade the resolution or introduce side lobes as a means of reducing aliasing and IM carrier bandwidth.

Adenosine A2A Receptor Modulates the Activity of Globus Pallidus Neurons in Rats

Directory of Open Access Journals (Sweden)

Hui-Ling Diao

2017-11-01

Full Text Available The globus pallidus is a central nucleus in the basal ganglia motor control circuit. Morphological studies have revealed the expression of adenosine A2A receptors in the globus pallidus. To determine the modulation of adenosine A2A receptors on the activity of pallidal neurons in both normal and parkinsonian rats, in vivo electrophysiological and behavioral tests were performed in the present study. The extracellular single unit recordings showed that micro-pressure administration of adenosine A2A receptor agonist, CGS21680, regulated the pallidal firing activity. GABAergic neurotransmission was involved in CGS21680-induced modulation of pallidal neurons via a PKA pathway. Furthermore, application of two adenosine A2A receptor antagonists, KW6002 or SCH442416, mainly increased the spontaneous firing of pallidal neurons, suggesting that endogenous adenosine system modulates the activity of pallidal neurons through adenosine A2A receptors. Finally, elevated body swing test (EBST showed that intrapallidal microinjection of adenosine A2A receptor agonist/antagonist induced ipsilateral/contralateral-biased swing, respectively. In addition, the electrophysiological and behavioral findings also revealed that activation of dopamine D2 receptors by quinpirole strengthened KW6002/SCH442416-induced excitation of pallidal activity. Co-application of quinpirole with KW6002 or SCH442416 alleviated biased swing in hemi-parkinsonian rats. Based on the present findings, we concluded that pallidal adenosine A2A receptors may be potentially useful in the treatment of Parkinson's disease.

Art Deco Furniture Designs in Republican Era: Selahattin Refik Sırmalı and the Study Room of Atatürk

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Çiler Buket Tosun

2014-12-01

Full Text Available This study presents the works of Selahattin Refik who played an active role in the Republican Era Architecture through his modern practices in interior architecture and furniture design. Practicing the most recent and popular art of his time, Art Deco, Refik also received the appreciation of Atatürk, and was influential in the first twenty years of the Republic. This study focuses on his interior and furniture designs for the ‘Study Room’ designed for Ataturk at the ‘Ataturk Museum House which is the first Official Residence of the President of the Republic of Turkey. Pioneering original Art Deco practices of our country, the ‘Study Room’ has been an implementation that illustrates not only the originality and competency of Selahattin Refik in practicing the modern art of the era but also the reflection of the modern identity of the Republic on interior designs.

E2F6: a member of the E2F family that does not modulate squamous differentiation

International Nuclear Information System (INIS)

Wong, C.F.; Barnes, Liam M.; Smith, Louise; Popa, Claudia; Serewko-Auret, Magdalena M.; Saunders, Nicholas A.

2004-01-01

The inhibition of E2F has been demonstrated to be important in the initiation of squamous differentiation by two independent manners: promotion of growth arrest and the relief of the differentiation-suppressive properties of E2Fs. E2F6 is reported to behave as a transcriptional repressor of the E2F family. In this study, we examined the ability of E2F6 to act as the molecular switch required for E2F inhibition in order for keratinocytes to enter a terminal differentiation programme. Results demonstrated that whilst E2F6 was able to suppress E2F activity in proliferating keratinocytes, it did not modulate squamous differentiation in a differentiated keratinocyte. Furthermore, inhibition of E2F, by overexpressing E2F6, was not sufficient to sensitise either proliferating keratinocytes or the squamous cell carcinoma cell line, KJD-1/SV40, to differentiation-inducing agents. Significantly, although E2F6 could suppress E2F activity in proliferating cells, it could not inhibit proliferation of KJD-1/SV40 cells. These results demonstrate that E2F6 does not contain the domains required for modulation of squamous differentiation and imply isoform-specific functions for individual E2F family members

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells.

Science.gov (United States)

Luessen, Deborah J; Hinshaw, Tyler P; Sun, Haiguo; Howlett, Allyn C; Marrs, Glen; McCool, Brian A; Chen, Rong

2016-11-01

Dysregulated expression and function of dopamine D2 receptors (D2Rs) are implicated in drug addiction, Parkinson's disease and schizophrenia. In the current study, we examined whether D2Rs are modulated by regulator of G protein signaling 2 (RGS2), a member of the RGS family that regulates G protein signaling via acceleration of GTPase activity. Using neuroblastoma 2a (N2A) cells, we found that RGS2 was immunoprecipitated by aluminum fluoride-activated Gαi2 proteins. RGS2 siRNA knockdown enhanced membrane [(35)S] GTPγS binding to activated Gαi/o proteins, augmented inhibition of cAMP accumulation and increased ERK phosphorylation in the presence of a D2/D3R agonist quinpirole when compared to scrambled siRNA treatment. These data suggest that RGS2 is a negative modulator of D2R-mediated Gαi/o signaling. Moreover, RGS2 knockdown slightly increased constitutive D2R internalization and markedly abolished quinpirole-induced D2R internalization assessed by immunocytochemistry. RGS2 knockdown did not compromise agonist-induced β-arrestin membrane recruitment; however, it prevents β-arrestin dissociation from the membrane after prolonged quinpirole treatment during which time β-arrestin moved away from the membrane in control cells. Additionally, confocal microscopy analysis of β-arrestin post-endocytic fate revealed that quinpirole treatment caused β-arrestin to translocate to the early and the recycling endosome in a time-dependent manner in control cells whereas translocation of β-arrestin to these endosomes did not occur in RGS2 knockdown cells. The impaired β-arrestin translocation likely contributed to the abolishment of quinpirole-stimulated D2R internalization in RGS2 knockdown cells. Thus, RGS2 is integral for β-arrestin-mediated D2R internalization. The current study revealed a novel regulation of D2R signaling and internalization by RGS2 proteins. Copyright © 2016 Elsevier Ltd. All rights reserved.

Study of curved glass photovoltaic module and module electrical isolation design requirements

Science.gov (United States)

1980-06-01

The design of a 1.2 by 2.4 m curved glass superstrate and support clip assembly is presented, along with the results of finite element computer analysis and a glass industry survey conducted to assess the technical and economic feasibility of the concept. Installed costs for four curved glass module array configurations are estimated and compared with cost previously reported for comparable flat glass module configurations. Electrical properties of candidate module encapsulation systems are evaluated along with present industry practice for the design and testing of electrical insulation systems. Electric design requirements for module encapsulation systems are also discussed.

Performance test of PSA-type O{sub 2} separator for efficient O{sub 2} supply to room ventilation system combined with CO{sub 2} adsorption module

Energy Technology Data Exchange (ETDEWEB)

Han, Gi Bo; Jang, Jung Hee; Choi, Changsik [Institute for Advanced Engineering, Yongin (Korea, Republic of); Lee, Tae Jin [School of Chemical Engineering Yeungnam University, Gyeongsan (Korea, Republic of)

2016-04-15

High purity O{sub 2} concentrated by the PSA-type O{sub 2} separator was applied to a room ventilation system combined with CO{sub 2} adsorption module to remove the indoor CO{sub 2} for the indoor air quality. And then the room was occupied by several persons to breathe for the O{sub 2} consumption and CO{sub 2} generation. As a result, the indoor air quality was improved by the ventilation system combined with the O{sub 2} supply and the CO{sub 2} adsorption module. It was due to the fact that the CO{sub 2} concentration was not steeply increased, but also even decreased and then the increasing rate of the O{sub 2} concentration with the O{sub 2} supply was simultaneously increased by the CO{sub 2} removal despite the CO{sub 2} generation and O{sub 2} consumption with the four persons' breathing. As a representative result, in the case of supplying the high purity O{sub 2} of 30 L/min under using the CO{sub 2} adsorption module, the best performance with the highest increasing rate of O{sub 2} concentration and the lowest increasing rate of CO{sub 2} concentration was obtained among the various cases, and then the increasing rates of CO{sub 2} radiation and O{sub 2} concentration were -2.3 ppm/min and 33.3%/min, respectively.

Comparing the effects of age on amplitude modulation and frequency modulation detection.

Science.gov (United States)

Wallaert, Nicolas; Moore, Brian C J; Lorenzi, Christian

2016-06-01

Frequency modulation (FM) and amplitude modulation (AM) detection thresholds were measured at 40 dB sensation level for young (22-28 yrs) and older (44-66 yrs) listeners with normal audiograms for a carrier frequency of 500 Hz and modulation rates of 2 and 20 Hz. The number of modulation cycles, N, varied between 2 and 9. For FM detection, uninformative AM at the same rate as the FM was superimposed to disrupt excitation-pattern cues. For both groups, AM and FM detection thresholds were lower for the 2-Hz than for the 20-Hz rate, and AM and FM detection thresholds decreased with increasing N. Thresholds were higher for older than for younger listeners, especially for FM detection at 2 Hz, possibly reflecting the effect of age on the use of temporal-fine-structure cues for 2-Hz FM detection. The effect of increasing N was similar across groups for both AM and FM. However, at 20 Hz, older listeners showed a greater effect of increasing N than younger listeners for both AM and FM. The results suggest that ageing reduces sensitivity to both excitation-pattern and temporal-fine-structure cues for modulation detection, but more so for the latter, while sparing temporal integration of these cues at low modulation rates.

Türkçe Öğretmeni Adaylarinin Dijital Pedagojik Yeterlilikleri The Digital Pedagogic Competencies Of Pre-Service Turkish-Language Teachers

Directory of Open Access Journals (Sweden)

Havva YAMAN

2013-09-01

Full Text Available The purpose of this study is to determine the competencies of preserviceTurkish teachers to use/create the digital tools within thecontext of technological changes brought to agenda within the scope of“Act of Increasing Opportunities and Improving Technology inEducation” (FATIH nominated as a digital change project of ourcountry. Pre-service teachers studying in the 3rd grade and 4th grade atthe Department of Turkish Language Teaching constitute the sample ofthe research. In this research survey model has been used andinstantaneous measurement has been preferred. “Digital and PedagogicCompetencies Scale of Pre-service Teachers” which was developed byresearchers as a data collection tool has been used. The acquiredfindings revealed what pre-service Turkish-language teachers lack andwhat to be focused on during the education of pre-service teachers.As a result, it is seen that pre-service Turkish-language teachershave a high level competency in educational digital pedagogy field andweb digital pedagogy while they have medium level competency ingeneral digital pedagogy field. The research has also shown that preserviceteachers with a good knowledge of computer and internet havean adequate level competency in digital pedagogy as well. In addition,male students have been seemed to be more competent in generaldigital pedagogy and web digital pedagogy fields when compared to thefemale ones. The research has shown that there is no differencebetween the competencies of 3rd and 4th grade students. The resultsacquired during this process are open to discussion and in order tomake the project more efficient within the scope of research, it isintended to determine the situation of pre-service teachers that aregoing to apply the project. Bu çalışmanın amacı “Eğitimde Fırsatları Arttırma Teknolojiyi İyileştirme Hareketi” (FATİH Projesi ile gündeme gelen teknolojik değişimler kapsamında Türkçe öğretmen adaylarının dijital ara

Borophene as a Promising Material for Charge-Modulated Switchable CO2 Capture.

Science.gov (United States)

Tan, Xin; Tahini, Hassan A; Smith, Sean C

2017-06-14

Ideal carbon dioxide (CO 2 ) capture materials for practical applications should bind CO 2 molecules neither too weakly to limit good loading kinetics nor too strongly to limit facile release. Although charge-modulated switchable CO 2 capture has been proposed to be a controllable, highly selective, and reversible CO 2 capture strategy, the development of a practical gas-adsorbent material remains a great challenge. In this study, by means of density functional theory (DFT) calculations, we have examined the possibility of conductive borophene nanosheets as promising sorbent materials for charge-modulated switchable CO 2 capture. Our results reveal that the binding strength of CO 2 molecules on negatively charged borophene can be significantly enhanced by injecting extra electrons into the adsorbent. At saturation CO 2 capture coverage, the negatively charged borophene achieves CO 2 capture capacities up to 6.73 × 10 14 cm -2 . In contrast to the other CO 2 capture methods, the CO 2 capture/release processes on negatively charged borophene are reversible with fast kinetics and can be easily controlled via switching on/off the charges carried by borophene nanosheets. Moreover, these negatively charged borophene nanosheets are highly selective for separating CO 2 from mixtures with CH 4 , H 2 , and/or N 2 . This theoretical exploration will provide helpful guidance for identifying experimentally feasible, controllable, highly selective, and high-capacity CO 2 capture materials with ideal thermodynamics and reversibility.

Auditory sensitivity to spectral modulation phase reversal as a function of modulation depth.

Science.gov (United States)

Buss, Emily; Grose, John

2018-01-01

The present study evaluated auditory sensitivity to spectral modulation by determining the modulation depth required to detect modulation phase reversal. This approach may be preferable to spectral modulation detection with a spectrally flat standard, since listeners appear unable to perform the task based on the detection of temporal modulation. While phase reversal thresholds are often evaluated by holding modulation depth constant and adjusting modulation rate, holding rate constant and adjusting modulation depth supports rate-specific assessment of modulation processing. Stimuli were pink noise samples, filtered into seven octave-wide bands (0.125-8 kHz) and spectrally modulated in dB. Experiment 1 measured performance as a function of modulation depth to determine appropriate units for adaptive threshold estimation. Experiment 2 compared thresholds in dB for modulation detection with a flat standard and modulation phase reversal; results supported the idea that temporal cues were available at high rates for the former but not the latter. Experiment 3 evaluated spectral modulation phase reversal thresholds for modulation that was restricted to either one or two neighboring bands. Flanking bands of unmodulated noise had a larger detrimental effect on one-band than two-band targets. Thresholds for high-rate modulation improved with increasing carrier frequency up to 2 kHz, whereas low-rate modulation appeared more consistent across frequency, particularly in the two-band condition. Experiment 4 measured spectral weights for spectral modulation phase reversal detection and found higher weights for bands in the spectral center of the stimulus than for the lowest (0.125 kHz) or highest (8 kHz) band. Experiment 5 compared performance for highly practiced and relatively naïve listeners, and found weak evidence of a larger practice effect at high than low spectral modulation rates. These results provide preliminary data for a task that may provide a better estimate of

Klystron-modulator system availability of PLS 2 GeV electron linac

International Nuclear Information System (INIS)

Cho, M.H.; Park, S.S.; Oh, J.S.; Namkung, W.

1996-01-01

PLS Linac has been injecting 2 GeV electron beams to the Pohang Light Source (PLS) storage ring since September 1994. PLS 2 GeV linac employs 11 sets of high power klystron-modulator (K and M) system for the main RF source for the beam acceleration. The klystron has rated output peak power of 80 MW at 4 microsec pulse width and at 60 pps. The matching modulator has 200 MW peak output power. The total accumulated high voltage run time of the oldest unit has reached beyond 23,000 hour and the sum of all the high voltage run time is approximately 230,000 hour as of May 1996. In this paper, we review overall system performance of the high-power K and M system. A special attention is paid on the analysis of all failures and troubles of the K and M system which affected the linac high power RF operations as well as beam injection operations for the period of 1994 to May 1996. (author)

Rat vas deferens SERCA2 is modulated by Ca{sup 2+}/calmodulin protein kinase II-mediated phosphorylation

Energy Technology Data Exchange (ETDEWEB)

Rodriguez, J.B.R.; Muzi-Filho, H. [Programa de Farmacologia e Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Valverde, R.H.F. [Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Quintas, L.E.M. [Programa de Farmacologia e Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Noel, F. [Programa de Desenvolvimento de Fármacos, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Einicker-Lamas, M. [Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil); Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem, Rio de Janeiro, RJ (Brazil); Cunha, V.M.N. [Programa de Farmacologia e Inflamação, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ (Brazil)

2013-03-19

Ca{sup 2+} pumps are important players in smooth muscle contraction. Nevertheless, little information is available about these pumps in the vas deferens. We have determined which subtype of sarco(endo)plasmic reticulum Ca{sup 2+}-ATPase isoform (SERCA) is expressed in rat vas deferens (RVD) and its modulation by calmodulin (CaM)-dependent mechanisms. The thapsigargin-sensitive Ca{sup 2+}-ATPase from a membrane fraction containing the highest SERCA levels in the RVD homogenate has the same molecular mass (∼115 kDa) as that of SERCA2 from the rat cerebellum. It has a very high affinity for Ca{sup 2+} (Ca{sub 0.5} = 780 nM) and a low sensitivity to vanadate (IC{sub 50} = 41 µM). These facts indicate that SERCA2 is present in the RVD. Immunoblotting for CaM and Ca{sup 2+}/calmodulin-dependent protein kinase II (CaMKII) showed the expression of these two regulatory proteins. Ca{sup 2+} and CaM increased serine-phosphorylated residues of the 115-kDa protein, indicating the involvement of CaMKII in the regulatory phosphorylation of SERCA2. Phosphorylation is accompanied by an 8-fold increase of thapsigargin-sensitive Ca{sup 2+} accumulation in the lumen of vesicles derived from these membranes. These data establish that SERCA2 in the RVD is modulated by Ca{sup 2+} and CaM, possibly via CaMKII, in a process that results in stimulation of Ca{sup 2+} pumping activity.

An ELMO2-RhoG-ILK network modulates microtubule dynamics.

Science.gov (United States)

Jackson, Bradley C; Ivanova, Iordanka A; Dagnino, Lina

2015-07-15

ELMO2 belongs to a family of scaffold proteins involved in phagocytosis and cell motility. ELMO2 can simultaneously bind integrin-linked kinase (ILK) and RhoG, forming tripartite ERI complexes. These complexes are involved in promoting β1 integrin-dependent directional migration in undifferentiated epidermal keratinocytes. ELMO2 and ILK have also separately been implicated in microtubule regulation at integrin-containing focal adhesions. During differentiation, epidermal keratinocytes cease to express integrins, but ERI complexes persist. Here we show an integrin-independent role of ERI complexes in modulation of microtubule dynamics in differentiated keratinocytes. Depletion of ERI complexes by inactivating the Ilk gene in these cells reduces microtubule growth and increases the frequency of catastrophe. Reciprocally, exogenous expression of ELMO2 or RhoG stabilizes microtubules, but only if ILK is also present. Mechanistically, activation of Rac1 downstream from ERI complexes mediates their effects on microtubule stability. In this pathway, Rac1 serves as a hub to modulate microtubule dynamics through two different routes: 1) phosphorylation and inactivation of the microtubule-destabilizing protein stathmin and 2) phosphorylation and inactivation of GSK-3β, which leads to the activation of CRMP2, promoting microtubule growth. At the cellular level, the absence of ERI species impairs Ca(2+)-mediated formation of adherens junctions, critical to maintaining mechanical integrity in the epidermis. Our findings support a key role for ERI species in integrin-independent stabilization of the microtubule network in differentiated keratinocytes. © 2015 Jackson et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Stark effect measurements on monomers and trimers of reconstituted light-harvesting complex II of plants

NARCIS (Netherlands)

Palacios, M.A.; Caffarri, S.; Bassi, R.; Grondelle, van R.; Amerongen, van H.

2004-01-01

The electric-field induced absorption changes (Stark effect) of reconstituted light-harvesting complex II (LHCII) in different oligomerisation states - monomers and trimers - with different xanthophyll content have been probed at 77 K. The Stark spectra of the reconstituted control samples,

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.

NARCIS (Netherlands)

Cairo, E.R.; Friedrich, T.; Swarts, H.G.P.; Knoers, N.V.A.M.; Bindels, R.J.M.; Monnens, L.A.H.; Willems, P.H.G.M.; Pont, J.J.H.H.M. de; Koenderink, J.B.

2008-01-01

Autosomal dominant renal hypomagnesemia, associated with hypocalciurea, has been linked to a G to A mutation at nucleotide position 121 in the FXYD2 gene, resulting in the substitution of Gly with Arg at residue 41 of the protein. FXYD2, also called the Na,K-ATPase gamma-subunit, binds to

Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats.

Science.gov (United States)

Finn, David P; Hudson, Alan L; Kinoshita, Hiroshi; Coventry, Toni L; Jessop, David S; Nutt, David J; Harbuz, Michael S

2004-03-01

Central noradrenaline regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis and the neuroendocrine response to stress. alpha2-adrenoceptors and imidazoline2 (I2) receptors modulate the activity of the central noradrenergic system. The present set of experiments investigated the role of alpha2-adrenoceptors and I2 receptors in the regulation of HPA axis activity under basal conditions and during exposure to the acute psychological stress of restraint. Three separate experiments were carried out in which rats were given an i.p. injection of either saline vehicle, the combined alpha2-adrenoceptor antagonist and I2 receptor ligand idazoxan (10 mg/kg), the selective I2 receptor ligand BU224 (2.5 or 10 mg/kg) or the selective alpha2-adrenoceptor antagonist RX821002 (2.5 mg/kg) with or without restraint stress. Drugs were administered immediately prior to restraint of 60 min duration. Blood was sampled pre-injection, 30, 60 and 240 min post-injection and plasma corticosterone was measured by radioimmunoassay. In experiment 1, idazoxan increased plasma corticosterone levels in naive animals and potentiated the corticosterone response to acute restraint stress. In experiment 2, BU224 administration increased plasma corticosterone levels in a dose-related manner in naive rats. The results of experiment 3 indicated that RX821002 also elevated plasma corticosterone levels in naive rats, however, only BU224 potentiated the corticosterone response to restraint stress. These studies suggest that both alpha2-adrenoceptors and I2 receptors play a role in modulating basal HPA axis activity and that I2 receptors may play a more important role than alpha2-adrenoceptors in modulating the HPA axis response to the acute psychological stress of restraint.

Geleneksel Türk ve Rum Düğünlerinden Bazı Kesitler Episodes Of Traditional Turkish And Greek Cypriot Weddings

Directory of Open Access Journals (Sweden)

Şevket ÖZNUR

2012-12-01

ğer bir değişle Kıbrıslı Türklerin ve Kıbrıslı Rumların düğün geleneklerini ve buna bağlı olarak özellikle müziği ve oyunlarını anlatırken bunların hem notlarını hem de sözlerini vermeye çalışacağız. Rumcadan aktaracağımız türkülerin Türkçe karşılıklarını da vermeye gayret etmiş bulunuyoruz.Bu sınırlı yazıda verdiğimiz Rum türkülerinin çoğunun Türk kültürüne ait olduğu açıkça görülebilmektedir. Yüzyıllardan beri iç içe ve Osmanlı yönetimi altında birlikte yaşamanın bir sonucu olarak Rumların, Türk kültüründen ne denli etkilendikleri bu yazımızdan da anlaşılmaktadır.Düğün yemeği olarak her iki toplumda da sunulan hersenin, gelinlerin duvak olarak kullanılan yüz örtüsünün kırmızı oluşu, melodilerin vb. değerlerin ortak oluşu görüşümüzün haklılığını ortaya koymaktadır.

TRITON vs POLARIS. Comparison Between Two Modules for LWRs Modelling in SCALE 6.2

Energy Technology Data Exchange (ETDEWEB)

Labarile, A.; Barrachina, T.; Miró, R.; Verdú, G.

2015-07-01

-One of them challenges more important in the research of reactors nuclear is the development of codes of best estimate that allow decrease them uncertainties of them calculations increasing the reliability of the results. You will also need sensitivity and uncertainty analysis and validation of the implemented code. This work offers a comparison of two modules of SCALE-6.2 for the case of a reactor's water to pressure (PWR). Based is in data from plant of the reactor Three thousands Island-1 is has calculated the keff and the cross sections effective with two modules in two dimensions (2-D) of the program SCALE: TRITON and POLARIS. TRITON is a module already validated for the calculation of the transport as POLARIS is located in distribution from end of the 2014. The objective is to compare the results of keff and cross sections of two simulations, and carry out a sensitivity analysis and uncertainty of the results. In TRITON and POLARIS calculations have been made to fuel elements of the PWR Three thousand Island-1, in two different configurations (with and without control rods), condition of stop in hot (HZP) and condition of full power (HFP). The results are presented in this work. A good correlation between the results of two simulations has found and, in addition, POLARIS module has presented less computational time and good stability in the parameters. After having compared the results obtained, a sensitivity analysis has been carried out to confirm the validation of two modules and study the influence of uncertainties in the calculation of the fuel element. (Author)

PIP2 modulation of slick and slack K+ channels

DEFF Research Database (Denmark)

Tejada, Maria de los Angeles; Jensen, Lars Jørn; Klærke, Dan Arne

2012-01-01

Slick and Slack are members of the Slo family of high-conductance potassium channels. These channels are activated by Na(+) and Cl(-) and are highly expressed in the CNS, where they are believed to contribute to the resting membrane potential of neurons and the control of excitability. Herein, we...... provide evidence that Slick and Slack channels are regulated by the phosphoinositide PIP(2). Two stereoisomers of PIP(2) were able to exogenously activate Slick and Slack channels expressed in Xenopus oocytes, and in addition, it is shown that Slick and Slack channels are modulated by endogenous PIP(2......). The activating effect of PIP(2) appears to occur by direct interaction with lysine 306 in Slick and lysine 339 in Slack, located at the proximal C-termini of both channels. Overall, our data suggest that PIP(2) is an important regulator of Slick and Slack channels, yet it is not involved in the recently...

Highly dexterous 2-module soft robot for intra-organ navigation in minimally invasive surgery.

Science.gov (United States)

Abidi, Haider; Gerboni, Giada; Brancadoro, Margherita; Fras, Jan; Diodato, Alessandro; Cianchetti, Matteo; Wurdemann, Helge; Althoefer, Kaspar; Menciassi, Arianna

2018-02-01

For some surgical interventions, like the Total Mesorectal Excision (TME), traditional laparoscopes lack the flexibility to safely maneuver and reach difficult surgical targets. This paper answers this need through designing, fabricating and modelling a highly dexterous 2-module soft robot for minimally invasive surgery (MIS). A soft robotic approach is proposed that uses flexible fluidic actuators (FFAs) allowing highly dexterous and inherently safe navigation. Dexterity is provided by an optimized design of fluid chambers within the robot modules. Safe physical interaction is ensured by fabricating the entire structure by soft and compliant elastomers, resulting in a squeezable 2-module robot. An inner free lumen/chamber along the central axis serves as a guide of flexible endoscopic tools. A constant curvature based inverse kinematics model is also proposed, providing insight into the robot capabilities. Experimental tests in a surgical scenario using a cadaver model are reported, demonstrating the robot advantages over standard systems in a realistic MIS environment. Simulations and experiments show the efficacy of the proposed soft robot. Copyright © 2017 John Wiley & Sons, Ltd.

A Comparison of Potential IM-CW Lidar Modulation Techniques for ASCENDS CO2 Column Measurements From Space

Science.gov (United States)

Campbell, Joel F.; Lin, Bing; Nehrir, Amin R.; Harrison, F. Wallace; Obland, Michael D.; Ismail, Syed

2014-01-01

Global atmospheric carbon dioxide (CO2) measurements through the Active Sensing of CO2 Emissions over Nights, Days, and Seasons (ASCENDS) Decadal Survey recommended space mission are critical for improving our understanding of CO2 sources and sinks. IM-CW (Intensity Modulated Continuous Wave) lidar techniques are investigated as a means of facilitating CO2 measurements from space to meet the ASCENDS science requirements. In previous laboratory and flight experiments we have successfully used linear swept frequency modulation to discriminate surface lidar returns from intermediate aerosol and cloud contamination. Furthermore, high accuracy and precision ranging to the surface as well as to the top of intermediate clouds, which is a requirement for the inversion of the CO2 column-mixing ratio from the instrument optical depth measurements, has been demonstrated with the linear swept frequency modulation technique. We are concurrently investigating advanced techniques to help improve the auto-correlation properties of the transmitted waveform implemented through physical hardware to make cloud rejection more robust in special restricted scenarios. Several different carrier based modulation techniques are compared including orthogonal linear swept, orthogonal non-linear swept, and Binary Phase Shift Keying (BPSK). Techniques are investigated that reduce or eliminate sidelobes. These techniques have excellent auto-correlation properties while possessing a finite bandwidth (by way of a new cyclic digital filter), which will reduce bias error in the presence of multiple scatterers. Our analyses show that the studied modulation techniques can increase the accuracy of CO2 column measurements from space. A comparison of various properties such as signal to noise ratio (SNR) and time-bandwidth product are discussed.

Expression of Arabidopsis FCS-Like Zinc finger genes is differentially regulated by sugars, cellular energy level, and abiotic stress

Directory of Open Access Journals (Sweden)

Muhammed eJamsheer K

2015-09-01

Full Text Available Cellular energy status is an important regulator of plant growth, development, and stress mitigation. Environmental stresses ultimately lead to energy deficit in the cell which activates the SNF1-RELATED KINASE 1 (SnRK1 signaling cascade which eventually triggering a massive reprogramming of transcription to enable the plant to survive under low-energy conditions. The role of Arabidopsis thaliana FCS-Like Zinc finger (FLZ gene family in energy and stress signaling is recently come to highlight after their interaction with kinase subunits of SnRK1 were identified. In a detailed expression analysis in different sugars, energy starvation, and replenishment series, we identified that the expression of most of the FLZ genes is differentially modulated by cellular energy level. It was found that FLZ gene family contains genes which are both positively and negatively regulated by energy deficit as well as energy-rich conditions. Genetic and pharmacological studies identified the role of HEXOKINASE 1- dependent and energy signaling pathways in the sugar-induced expression of FLZ genes. Further, these genes were also found to be highly responsive to different stresses as well as abscisic acid. In over-expression of kinase subunit of SnRK1, FLZ genes were found to be differentially regulated in accordance with their response towards energy fluctuation suggesting that these genes may work downstream to the established SnRK1 signaling under low-energy stress. Taken together, the present study provides a conceptual framework for further studies related to SnRK1-FLZ interaction in relation to sugar and energy signaling and stress response.

Comparison of fractions of inactive modules between Run1 and Run2

CERN Document Server

Motohashi, Kazuki; The ATLAS collaboration

2015-01-01

Fraction of inactive modules for each component of the ATLAS pixel detector at the end of Run 1 and the beginning of Run 2. A similar plot which uses a result of functionality tests during LS1 can be found in ATL-INDET-SLIDE-2014-388.

Purification and partial elucidation of the structure of an antioxidant carbohydrate biopolymer from the probiotic bacterium Bacillus coagulans RK-02.

Science.gov (United States)

Kodali, Vidya P; Perali, Ramu S; Sen, R

2011-08-26

An exopolysaccharide (EPS) was isolated from Bacillus coagulans RK-02 and purified by size exclusion chromatography. The purified, homogeneous EPS had an average molecular weight of ∼3 × 10⁴ Da by comparison with FITC-labeled dextran standards. In vivo evaluations showed that, like other reported polysaccharides, this EPS displayed significant antioxidant activity. FTIR spectroscopy analysis showed the presence of hydroxy, carboxy, and α-glycosidic linkages and a mannose residue. GC analysis indicated that the EPS was a heteropolymer composed of glucose, mannose, galactose, glucosamine, and fucose as monomeric constituent units. Partial elucidation of the structure of the carbohydrate biopolymer based on GC-MS and NMR analysis showed the presence of two unique sets of tetrasaccharide repeating units that have 1→3 and 1→6 glycosidic linkages. This is also the first report of a Gram-positive bacterial polysaccharide with both fucose as a sugar monomer and 1→3 and 1→6 glycosidic linkages in the molecular backbone.

Changes in modulation period of Bi sub 2 Sr sub 2 (Ca sub 1-x Nd sub x )Cu sub 2 O sub 8+. delta. and their relations to oxygen content

Energy Technology Data Exchange (ETDEWEB)

Onozuka, Takashi; Tokiwa, Ayako; Syono, Yasuhiko (Inst. for Materials Research, Tohoku Univ., Sendai (Japan)); Koike, Yoji; Saito, Yoshitami (Dept. of Applied Physics, Tohoku Univ., Sendai (Japan))

1991-12-01

Structural changes of long-period modulated structure (LPMS) of the Bi{sub 2}Sr{sub 2}(Ca{sub 1-x}Nd{sub x})Cu{sub 2}O{sub 8+{delta}} ceramics with x are investigated by means of electron diffraction. Increasing x, the modulation mode of the mixing of domains of two modulation periods with b=4.5b{sub o} and b=5b{sub o} changes to that with b=4.5b{sub o} and b=4b{sub o} through the modulation mode with only b=4.5b{sub o} at x=0.4-0.5. The wavenumber of the superlattice reflection shows a stepwise increase rather than a linear increase with x. Excess oxygen in a LPMS model with the site of excess oxygen is shown to be consistent with excess oxygen analyzed chemically by iodometry and its change with x. (orig.).

Klasik Türk Mûsikîsinin Temel Sazlarından Neyde Basit Göçürme (Şed Teknikleri / Simple Transposition Techniques in the Nay, Which is Among the Basic Instruments of Classical Turkish Music

Directory of Open Access Journals (Sweden)

Muhammet Sevinç

2017-12-01

Full Text Available Abstract Nay (red flute, the instrument of music, is one of the main instruments of Turkish classical music and especially religious music for centuries. In this article, we will provide information about history and shape of nay and some simple techniques regarding transposing. In terms of execution, this advanced technique is important to use the instrument effectively by moving a collection of notes up or down in pitch by a constant interval. Thus we explained a few of Turkish music modes for convenience. By transposing some music notes, this study helps for music students and nay players. The article provides some examples of transposed works in its appendix as well. Öz Ney sazı, yüzyıllardır klasik Türk mûsikîsinin ve özellikle Türk din mûsikîsinin en temel çalgılarından birisi olmuştur. Bu makalede ney sazının tarihi ve yapısı hakkında bazı kısa bilgiler verilip icra açısından basit göçürme tekniklerine dair örnekler incelenmiştir. Şed veya göçürme de denilen bu teknik hemen her sazda icrada ileri seviyeye geçme ve sazı yenme açısından önem arz eder. Bu sebeple çalışmamızda, Türk mûsikîsi makamlarından birkaç tanesini başka perdelere göçürerek sazendelere kolaylık sağlamayı amaçladık. Örnek diziler ve ek bölümde verilen eserler kız neyde icra edildiğinde bolahenk nısfiye, mansur neyde icra edildiğinde ise süpürde akordu elde edilecektir.

Design, synthesis, and activity of 2,3-diphosphoglycerate analogs as allosteric modulators of hemoglobin O2 affinity.

Science.gov (United States)

Kassa, Tigist W; Zhang, Ning; Palmer, Andre F; Matthews, Jason Shastri

2013-04-01

Four phosphonate derivates of 2,3-diphosphoglycerate (2,3-DPG), in which the phosphate group is replaced by a methylene or difluoromethylene, were successfully synthesized for use as allosteric modulators of hemoglobin (Hb) O2 affinity. The syntheses were accomplished in four steps and the reagents were converted to their potassium salts to allow for effective binding with Hb in aqueous media. O2 equilibrium measurements of the chemically modified Hbs exhibited P50 values in the range 8.9-12.8 with Hill coefficients in the range of 1.5-2.4.

Photovoltaic concentrator module improvements study

Energy Technology Data Exchange (ETDEWEB)

Levy, S.L.; Kerschen, K.A. (Black and Veatch, Kansas City, MO (United States)); Hutchison, G. (Solar Kinetics, Inc., Dallas, TX (United States)); Nowlan, M.J. (Spire Corp., Bedford, MA (United States))

1991-08-01

This report presents results of a project to design and fabricate an improved photovoltaic concentrator module. Using previous work as a baseline, this study conducted analyses and testing to select major module components and design features. The lens parquet and concentrator solar cell were selected from the highest performing, available components. A single 185X point-focus module was fabricated by the project team and tested at Sandia. Major module characteristics include a 6 by 4 compression-molded acrylic lens parquet (0.737 m{sup 2} area), twenty-four 0.2 ohms-cm, FZ, p-Si solar cells (1.56 cm{sup 2} area) soldered to ceramic substrates and copper heat spreaders, and an aluminized steel housing with corrugated bottom. This project marked the first attempt to use prismatic covers on solar cells in a high-concentration, point-focus application. Cells with 15 percent metallization were obtained, but problems with the fabrication and placement of prismatic covers on these cells lead to the decision not to use covers in the prototype module. Cell assembly fabrication, module fabrication, and module optical design activities are presented here. Test results are also presented for bare cells, cell assemblies, and module. At operating conditions of 981 watts/m{sup 2} DNI and an estimated cell temperature of 65{degrees}C, the module demonstrated an efficiency of 13.9 percent prior to stressed environmental exposure. 12 refs., 56 figs., 7 tabs.

Characterization of Cu(In,Ga)Se2 photovoltaic modules

International Nuclear Information System (INIS)

Dyk, E.E. van; Radue, C.; Gxasheka, A.R.

2007-01-01

In this study copper indium gallium diselenide photovoltaic (PV) modules were subjected to a thorough indoor assessment procedure. The assessment is to be used as a baseline for future evaluation of the modules deployed outdoors as part of an ongoing evaluation of device performance and degradation. The main focus of the study is the long term monitoring of the devices to determine service lifetime. In this paper we will present initial results of the baseline evaluation, namely I-V characteristics, thorough visual inspection and an analysis of performance parameters. The results obtained revealed that the performance of one of the modules was inferior to the others evaluated. In order to further investigate this, laser beam induced current (LBIC) measurements were conducted on regions that had a non-uniform appearance as observed visually

Demonstration of high mobility and quantum transport in modulation-doped β-(AlxGa1-x)2O3/Ga2O3 heterostructures

Science.gov (United States)

Zhang, Yuewei; Neal, Adam; Xia, Zhanbo; Joishi, Chandan; Johnson, Jared M.; Zheng, Yuanhua; Bajaj, Sanyam; Brenner, Mark; Dorsey, Donald; Chabak, Kelson; Jessen, Gregg; Hwang, Jinwoo; Mou, Shin; Heremans, Joseph P.; Rajan, Siddharth

2018-04-01

In this work, we demonstrate a high mobility two-dimensional electron gas (2DEG) formed at the β-(AlxGa1-x)2O3/Ga2O3 interface through modulation doping. Shubnikov-de Haas (SdH) oscillations were observed in the modulation-doped β-(AlxGa1-x)2O3/Ga2O3 structure, indicating a high-quality electron channel formed at the heterojunction interface. The formation of the 2DEG channel was further confirmed by the weak temperature dependence of the carrier density, and the peak low temperature mobility was found to be 2790 cm2/Vs, which is significantly higher than that achieved in bulk-doped Beta-phase Gallium Oxide (β-Ga2O3). The observed SdH oscillations allowed for the extraction of the electron effective mass in the (010) plane to be 0.313 ± 0.015 m0 and the quantum scattering time to be 0.33 ps at 3.5 K. The demonstrated modulation-doped β-(AlxGa1-x)2O3/Ga2O3 structure lays the foundation for future exploration of quantum physical phenomena and semiconductor device technologies based on the β-Ga2O3 material system.

Influence of defects on the incommensurate modulation in irradiated Ba2NaNb5O15

International Nuclear Information System (INIS)

Barre, S.; Mutka, H.; Roucau, C.; Litzler, A.; Schneck, J.; Toledano, J.C.; Bouffard, S.; Rullier-Albenque, F.

1991-01-01

Defect-induced properties of barium sodium niobate (Ba 2 NaNb 5 O 15 ) have been studied as a function of electron irradiation dose. Birefringence measurements at low doses indicate that the lock-in transition temperature, originally at about 280 degree C, decreases linearly with increasing dose. Complementary irradiations in situ in a high-voltage electron microscope show that the incommensurate phase can be stabilized down to room temperature. Simultaneously the satellite diffraction spots broaden and the lock-in transition becomes diffuse. The modification of the hysteresis of the birefringence, observed already at the lowest doses, indicates a progressive extension of the stability range of the 2q modulated phase to lower temperatures as the defect concentration increases. A similar conclusion can be drawn from the satellite reflection dark-field electron micrographs that show, once the incommensurate phase is stabilized at room temperature, the doubly modulated texture characteristic of the 2q modulated phase. Low doses of irradiation do not change qualitatively the configuration of the residual discommensurations in the lock-in phase nor the temperature dependence of the incommensurability. Accordingly, already in the as-grown samples the defects dominate the pinning of the incommensurate modulation and the intrinsic properties of this incommensurate system are not clearly observable

Should patients with Björk-Shiley valves undergo prophylactic replacement?

Science.gov (United States)

Birkmeyer, J D; Marrin, C A; O'Connor, G T

1992-08-29

About 85,000 patients have undergone replacement of diseased heart valves with prosthetic Björk-Shiley convexo-concave (CC) valves. These valves are prone to fracture of the outlet strut, which leads to acute valve failure that is usually fatal. Should patients with these valves undergo prophylactic replacement to avoid fracture? The incidence of strut fracture varies between 0% and 1.5% per year, depending on valve opening angle (60 degrees or 70 degrees), diameter (less than 29 mm or greater than or equal to 29 mm), and location (aortic or mitral). Other factors include the patient's life expectancy and the expected morbidity and mortality associated with reoperation. We have used decision analysis to identify the patients most likely to benefit from prophylactic reoperation. The incidence of outlet strut fracture was estimated from the data of three large studies on CC valves, and stratified by opening angle, diameter, and location. A Markov decision analysis model was used to estimate life expectancy for patients undergoing prophylactic valve replacement and for those not undergoing reoperation. Prophylactic valve replacement does not benefit patients with CC valves that have low strut fracture risks (60 degrees aortic valves and less than 29 mm, 60 degrees mitral valves). For most patients with CC valves that have high strut fracture risks (greater than or equal to 29 mm, 70 degrees CC), prophylactic valve replacement increases life expectancy. However, elderly patients with such valves benefit from prophylactic reoperation only if the risk of operative mortality is low. Patient age and operative risk are most important in recommendations for patients with CC valves that have intermediate strut fracture risks (less than 29 mm, 70 degrees valves and greater than or equal to 29 mm, 60 degrees mitral valves). For all patients and their doctors facing the difficult decision on whether to replace CC valves, individual estimates of operative mortality risk that

Nociceptive transmission and modulation via P2X receptors in central pain syndrome.

Science.gov (United States)

Kuan, Yung-Hui; Shyu, Bai-Chuang

2016-05-26

Painful sensations are some of the most frequent complaints of patients who are admitted to local medical clinics. Persistent pain varies according to its causes, often resulting from local tissue damage or inflammation. Central somatosensory pathway lesions that are not adequately relieved can consequently cause central pain syndrome or central neuropathic pain. Research on the molecular mechanisms that underlie this pathogenesis is important for treating such pain. To date, evidence suggests the involvement of ion channels, including adenosine triphosphate (ATP)-gated cation channel P2X receptors, in central nervous system pain transmission and persistent modulation upon and following the occurrence of neuropathic pain. Several P2X receptor subtypes, including P2X2, P2X3, P2X4, and P2X7, have been shown to play diverse roles in the pathogenesis of central pain including the mediation of fast transmission in the peripheral nervous system and modulation of neuronal activity in the central nervous system. This review article highlights the role of the P2X family of ATP receptors in the pathogenesis of central neuropathic pain and pain transmission. We discuss basic research that may be translated to clinical application, suggesting that P2X receptors may be treatment targets for central pain syndrome.

Experimental Investigations of 3-D-/4-D-CAP Modulation With Directly Modulated VCSELs

DEFF Research Database (Denmark)

Binti Othman, Maisara; Zhang, Xu; Deng, Lei

2012-01-01

correction limit of 2.8 × 10-3 for error-free reception is achieved after 20 km of SSMF transmission. Spectral efficiencies of 2.68 and 2.08 b/s/Hz are reported for 3-D-CAP and 4-D-CAP, respectively. We believe that multidimensional modulation formats represent an attractive solution for providing more......In this letter, we present experimental investigations of multidimensional multilevel carrierless amplitude phase (CAP) modulation with directly modulated vertical cavity surface-emitting lasers. The signals are transmitted over 20 km of standard single-mode fiber (SSMF). For multilevel 3-D...

Türkiye Türkçesi Ağızlarında Özellikleri Bakımından Yağış Türlerine Verilen Adlar The Names That Given to Kinds of Precipitation in Turkey Turkish Dialects for Their Charateristics

Directory of Open Access Journals (Sweden)

Selim EMİROĞLU

2012-09-01

Full Text Available Turkey Turkish dialects have a rich vocabulary. Many words which reflects the culture of the Turkish nation from the past and not included in the standard Turkish were living and used in the people language. There are hundreds of words in Turkey Turkish dialects names as color, food, body, kinship, disease, animal, units of measure, clothes and so on. The names of precipitation has also important place in there. In this study, the kinds of precipitation in turkey turkish dialects are classified by considering for their various characteristics. The names used for rain and snow of kinds of precipitation has been given by considering such characteristics continuity, quantity and speed of this kinds of precipitations; bigness and smallness of raindrop and snowflake; the time of precipitation falls to earth (seasons, months, days, hours, etc.; the direction of precipitation, the precipitation be synchronous with other natural events (wind, sunlight, fog, etc.. Various comments and assessments have been reached with through the names of precipitation were identified and classified. The study shows turkish people seperated expertly the kinds of precipitation that seemingly thought to have been the same, from each other by looking at the various characteristics of these kinds of precipitation and with different names. In addition to, there is a glossary that containing the meanings of the words identified and classified in terms of their characteristics at the end of the study. The data of study were obtained through scanning the Compiling Dictionary. However, to determine the usage in standard Turkish, it have scanned Great Turkish Dictionary. The data gotten prove the richness of Turkish related to precipitation. These words in dialects related to precipitation must be included in Standard Turkish. Türkiye Türkçesi ağızları zengin bir söz varlığına sahiptir. Türk milletinin geçmişten beri gelen kültürünü yansıtan ve standart Türk

MESNEVIES OF MIHR U MUSTERÎ IN TURKISH LITERATURE AND MÎRÎ’S MIHR U MUSTERÎ TÜRK EDEBİYATINDA MİHR Ü MÜŞTERÎ MESNEVİLERİ VE MÎRÎ’NİN MİHR Ü MÜŞTERÎ’Sİ

Directory of Open Access Journals (Sweden)

Mustafa ARSLAN

2009-10-01

Full Text Available This article provides information about the source of Mihr ü Müşterî mesnevîs and were written in Turkish literature Mihr ü Müşterîs have been mentioned briefly. Important part of the research constitutes Mîrî (Kiçi Mîr-zade Seyyid Yahya Hüseyin, died. 1008/1599’s Mihr ü Müşterî. That have not been done before any work on the full text mesnevî was read by us and published before the first stage in this article is presented to the attention of researchers. Mesnevî is Iranian poet Assâr (Sheikh Mohammed Assâr-i Tabrizi, died. 784/1382’s translation of the same name. The difference of classic hero mesnevî’s other couples heros classical love mesnevî, both heroes is the man. The work, in terms of interaction’s concrete example between Turkish literature and Iran literature is importance. Working with the same subject classical Eastern literature in Turkish literature in the context in which mesnevîs (copyright, translation, etc nazire should be evaluated in the matter may be a model. We stand on this mesnevi, language is important in terms of belonging to the Old Anatolian Turkish period, contains many archaic words. This aspect of the remarkable work with the scanned and obtained by Kilisli Muallim Rıfatand language materials is used Tarama Sözlüğü prepared by the Türk Dil Kurumu. Bu yazıda Mihr ü Müşterî mesnevîlerinin kaynağı ile ilgili bilgi verilmiş ve Türk edebiyatında yazılan Mihr ü Müşterî’lerden kısaca söz edilmiştir. Araştırmanın önemli bölümünü Mîrî (Kiçi Mîr-zade Seyyid Yahya Hüseyin, öl. 1008/1599’nin Mihr ü Müşterî’si oluşturmaktadır. Daha önce üzerinde herhangi bir çalışma yapılmamış olan mesnevînin tam metni tarafımızdan okunmuştur ve yayın aşamasından önce ilk defa bu yazıda araştırmacıların dikkatine sunulmaktadır. Mesnevî İranlı şair Assâr (Şeyh Muhammed Assâr-ı Tebrizî, öl. 784/1382’nin aynı addaki eserinin terc

End user reliability assessment of 1.2-1.7 kV commercial SiC MOSFET power modules

DEFF Research Database (Denmark)

Ionita, Claudiu; Nawaz, Muhammad

2017-01-01

This paper is a first attempt to offer reliability evaluation of full SiC power modules where several dies are connected in parallel to increase power rating capability. Here, five different power modules with voltage rating from 1.2-1.7 kV and current rating from 120-800 A from three vendors hav......, which is connected in parallel with the MOSFET chip. For another module, there has also been recorded a failure of the gate oxide during H3TRB....

Improvement of the NSSS T/H Module ARTS for Enhancing the Simulation Fidelity of YGN no 1/2 Simulator

International Nuclear Information System (INIS)

Seo, In Yong; Lee, Myung Soo; Lee, Yong Kwan; Suh, Jae Seung; Jeun, Gyoo Dong

2006-01-01

KEPRI(Korea Electric Power Research Institute) and KAERI(Korea Atomic Energy Research Institute) developed a NSSS (Nuclear Steam Supply System) T/H (Thermal-Hydraulic) module (named ARTS) based on the best-estimate code RETRAN-3D for the KNPEC-2 full-scope simulator in 2001. Although ARTS can simulate the most transients in real-time, and its robustness is ensured, real-time calculation and robustness can fail for large break loss-of-coolant accident (LBLOCA) and long term, two-phase transients. In order to improve its robustness, ARTS equipped with the backup calculation module to be used whenever a regular ARTS module fails to calculate. When the symptom for the failure of T/H module is detected, the main ARTS module is replaced with the backup module for the calculation of primary and secondary reactor system although most failures of ARTS occur in the calculation of the primary system especially for LBLOCA simulation. The sudden transition from the main ARTS module to the backup module can exhibit the discontinuity of simulation of secondary system on rare occasions. To mitigate the simulation discontinuity, we have improved the backup module of ARTS. The performance of a new approach has been illustrated by the non-integrated standalone test. The improved ARTS module will be incorporated into YGN no. 1/2 simulator and evaluated its performance in the real simulator environment. This paper presents the brief description of a new backup calculation strategy and the simulation results of LOCA to evaluate the performance of a new backup strategy in standalone test environment

ÜÇ MAYMUN, PANDORA’NIN KUTUSU, GÜZEL GÜNLER GÖRECEĞİZ, NAR, GERİYE KALAN, ŞİMDİKİ ZAMAN VE ZERRE FİLM ÖRNEKLERİYLE: TÜRK SİNEMASINDA KENTLİ KADIN OLGUSU

Directory of Open Access Journals (Sweden)

Gül Yaşartürk Yaşartürk

2015-01-01

Full Text Available Türk sinemasında ilk yıllarından başlamak üzere sınıf farkı, kültür farkı, yaşam biçimi, giyim-kuşam, aile ve cinsiyet rollerinde modern ve geleneksel karşıtlıkları çoğu zaman kent ve taşra ayrımında ortaya konulur. Bu filmlerde çoğu zaman, dürüst, ahlaklı, değerlerine bağlı ve inançlı olmak, namus ve şeref gibi değerler taşra kültürü ile özdeşleştirilirken, modern, Batılı yaşam tarzı, aile, inanç ve değerlerinden uzaklaşmış, ahlaki çöküntü içinde yaşayan, içki ve ihanetin pençesinde kıvranan kentlilere, dolayısıyla kent kültürüne dayatılır. Ancak özellikle 1940’lı yıllardan başlayan ve hızla devam eden taşradan kente göçle birlikte taşra kent, merkez ve periferisi bağlamında kent ve kentli kavramları da değişim ve dönüşüme uğramıştır.  Bu çalışmada günümüz Türk sinemasında kentli kadın olgusunu kadın ve kent ilişkisi bağlamında örnek film analizleriyle ortaya koymayı amaçlamaktadır. Bu amaçla 2000’li yıllardan itibaren Türk sinemasında kentli kadın temsilleri yedi film örneğinde niteliksel içerik analizi yöntemi ile incelenecektir.

Differential protein modulation in midguts of Aedes aegypti infected with chikungunya and dengue 2 viruses.

Science.gov (United States)

Tchankouo-Nguetcheu, Stéphane; Khun, Huot; Pincet, Laurence; Roux, Pascal; Bahut, Muriel; Huerre, Michel; Guette, Catherine; Choumet, Valérie

2010-10-05

Arthropod borne virus infections cause several emerging and resurgent infectious diseases. Among the diseases caused by arboviruses, dengue and chikungunya are responsible for a high rate of severe human diseases worldwide. The midgut of mosquitoes is the first barrier for pathogen transmission and is a target organ where arboviruses must replicate prior to infecting other organs. A proteomic approach was undertaken to characterize the key virus/vector interactions and host protein modifications that happen in the midgut for viral transmission to eventually take place. Using a proteomics differential approach with two-Dimensional Differential in-Gel Electrophoresis (2D-DIGE), we defined the protein modulations in the midgut of Aedes aegypti that were triggered seven days after an oral infection (7 DPI) with dengue 2 (DENV-2) and chikungunya (CHIKV) viruses. Gel profile comparisons showed that the level of 18 proteins was modulated by DENV-2 only and 12 proteins were modulated by CHIKV only. Twenty proteins were regulated by both viruses in either similar or different ways. Both viruses caused an increase of proteins involved in the generation of reactive oxygen species, energy production, and carbohydrate and lipid metabolism. Midgut infection by DENV-2 and CHIKV triggered an antioxidant response. CHIKV infection produced an increase of proteins involved in detoxification. Our study constitutes the first analysis of the protein response of Aedes aegypti's midgut infected with viruses belonging to different families. It shows that the differentially regulated proteins in response to viral infection include structural, redox, regulatory proteins, and enzymes for several metabolic pathways. Some of these proteins like antioxidant are probably involved in cell protection. On the other hand, we propose that the modulation of other proteins like transferrin, hsp60 and alpha glucosidase, may favour virus survival, replication and transmission, suggesting a subversion of