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Sample records for rita sharma thomas

  1. Ashok Sharma

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Ashok Sharma. Articles written in Bulletin of Materials Science. Volume 28 Issue 7 December 2005 pp 725-729 Biomaterials. Supramolecular structure of S-(+)-marmesin-a linear dihydrofuranocoumarin · Sanjeev Goswami Vivek K Gupta Ashok Sharma B D Gupta.

  2. Robin Sharma : juhtimine on lihtne / Robin Sharma ; intervjueerinud Nelli Pello

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Eestit külastanud maailma tunnustatumaid koolitajaid Robin Sharma, kes viis läbi seminari "Eestvedamise meistriklass", vastab küsimustele Eesti-muljete ja juhtimise kohta. Lisa: Robin Sharma mõtteteri. Kommenteerivad: Indrek Pertelson, Anne Samlik

  3. Juhtimisguru Robin Sharma naudib vaikusehetki / Robin Sharma ; interv. Kristo Kiviorg

    Index Scriptorium Estoniae

    Sharma, Robin

    2008-01-01

    Ilmunud ka: Delovõje Vedomosti 5. märts lk. 12. Juhtimisguru Robin Sharma leiab, et inimesed peaksid leidma päevas tunni iseenese jaoks, sest see aitab leida õiged perspektiivid ning loob eelduse heade ideede tekkeks. Lisa: Robin S. Sharma. Kommenteerivad Kadri Arula ja Asko Talu

  4. S L Sharma

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. S L Sharma. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 85-93 Materials Synthesis. Photoelectronic properties of HgI2 crystals for nuclear radiation detection · S L Sharma H N Acharya · More Details Abstract Fulltext PDF. Photoelectronic ...

  5. T P Sharma

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. T P Sharma. Articles written in Bulletin of Materials Science. Volume 26 Issue 4 June 2003 pp 387-389 Magnetic Materials. Band gap determination of Ni–Zn ferrites · G P Joshi N S Saxena R Mangal A Mishra T P Sharma · More Details Abstract Fulltext PDF. Nanocomposites of ...

  6. Sharma, Prof. Shobhona

    Indian Academy of Sciences (India)

    Sharma, Prof. Shobhona Ph.D. (Mumbai), FNA. Date of birth: 5 February 1953. Specialization: Molecular Parasitology, Parasite Immunology and Parasite Metabolism Address: Senior Professor & Chairperson, Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, ...

  7. Vijay Kumar Sharma

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education. Vijay Kumar Sharma. Articles written in Resonance – Journal of Science Education. Volume 4 Issue 1 January 1999 pp 73-75 Research News. Adaptive Significance of Circadian Rhythms - Biological Clocks and Darwinian Fitness in Cyanobacteria · V Sheeba ...

  8. Sharma, Dr Ram Swaroop

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1989 Section: Earth & Planetary Sciences. Sharma, Dr Ram Swaroop Ph.D. (Basel), FNA. Date of birth: 10 July 1937. Specialization: Metamorphic Petrology, Mineralogy and Precambrian Geology Address: 70/36, Pratapnagar, Sector 7, Sanganer (RHB), Jaipur 302 033, Rajasthan

  9. Sharma, Dr Surendra Kumar

    Indian Academy of Sciences (India)

    Elected: 2010 Section: Medicine. Sharma, Dr Surendra Kumar Ph.D. (AIIMS), MD (PGIMER, Chandigarh), FNASc, FNA. Date of birth: 22 February 1951. Specialization: Environmental Medicine, Infectious Diseases, Internal Medicine, Pulmonary & Critical Care and Sleep Medicine Address: B-5/3, B Block, Sector 13, RK ...

  10. Lens proteome map and alpha-crystallin profile of the catfish Rita rita.

    Science.gov (United States)

    Mohanty, Bimal Prasanna; Bhattacharjee, Soma; Das, Manas Kumar

    2011-02-01

    Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different model and non-model species for understanding the modifications they undergo with ageing that lead to cataract, a disease of protein aggregation. In the present investigation, we studied the lens crystallin profile of the tropical freshwater catfish Rita rita. Profiles of lens crystallins were analyzed and crystallin proteome maps of Rita rita were generated for the first time. alphaA-crystallins, member of the alpha-crystallin family, which are molecular chaperons and play crucial role in maintaining lens transparency were identified by 1- and 2-D immunoblot analysis with anti-alphaA-crystallin antibody. Two protein bands of 19-20 kDa were identified as alphaA-crystallins on 1-D immunoblots and these bands separated into 10 discrete spots on 2-D immunoblot. However, anti-alphaB-crystallin and antiphospho-alphaB-crystallin antibodies were not able to detect any immunoreactive bands on 1- and 2-D immunoblots, indicating alphaB-crystallin was either absent or present in extremely low concentration in Rita rita lens. Thus, Rita rita alpha-crystallins are more like that of the catfish Clarias batrachus and the mammal kangaroo in its alphaA- and alphaB-crystallin content (contain low amount from 5-9% of alphaB-crystallin) and unlike the dogfish, zebrafish, human, bovine and mouse alpha-crystallins (contain higher amount of alphaB-crystallin from 25% in mouse and bovine to 85% in dogfish). Results of the present study can be the baseline information for stimulating further investigation on Rita rita lens crystallins for comparative lens proteomics. Comparing and contrasting the alpha-crystallins of the dogfish and Rita rita may provide valuable information on the functional attributes of alphaA- and alphaB-isoforms, as

  11. Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae).

    Science.gov (United States)

    Lashari, Punhal; Laghari, Muhammad Younis; Xu, Peng; Zhao, Zixia; Jiang, Li; Narejo, Naeem Tariq; Deng, Yulin; Sun, Xiaowen; Zhang, Yan

    2015-01-01

    The complete mitochondrial genome of Catfish, Rita rita, was isolated by LA PCR (TakaRa LAtaq, Dalian, China); and sequenced by Sanger's method to obtain the complete mitochondrial genome, which is listed Critically Endangered and Red Listed species. The complete mitogenome was 16,449 bp in length and contains 13 typical vertebrate protein-coding genes, 2 rRNA and 22 tRNA genes. The whole genome base composition was estimated to be 33.40% A, 27.43% C, 14.26% G and 24.89% T. The complete mitochondrial genome of catfish, Rita rita provides the basis for genetic breeding and conservation studies.

  12. RITA-type triple axis spectrometers

    International Nuclear Information System (INIS)

    Roennow, H.M.

    2001-01-01

    The RITA spectrometer at Risoe National Laboratory was the first to incorporate a complete re-thinking of the neutron-path from source, through detector to analysis. Since then, other RITA-type spectrometers such as SPINS at NIST, RITA-II at PSI have been built, and several new spectrometers around the world are adapting the same philosophy. The main novelty of RITA was the introduction of a single back-end tank featuring both an analyser block with multiple individually turnable analyser blades and a 2D position sensitive detector. Several new triple-axis spectrometers are presently being built at existing and future sources, and almost all of them have learnt from the experience with RITA. (R.P.)

  13. Chk2 mediates RITA-induced apoptosis.

    Science.gov (United States)

    de Lange, J; Verlaan-de Vries, M; Teunisse, A F A S; Jochemsen, A G

    2012-06-01

    Reactivation of the p53 tumor-suppressor protein by small molecules like Nutlin-3 and RITA (reactivation of p53 and induction of tumor cell apoptosis) is a promising strategy for cancer therapy. The molecular mechanisms involved in the responses to RITA remain enigmatic. Several groups reported the induction of a p53-dependent DNA damage response. Furthermore, the existence of a p53-dependent S-phase checkpoint has been suggested, involving the checkpoint kinase Chk1. We have recently shown synergistic induction of apoptosis by RITA in combination with Nutlin-3, and we observed concomitant Chk2 phosphorylation. Therefore, we investigated whether Chk2 contributes to the cellular responses to RITA. Strikingly, the induction of apoptosis seemed entirely Chk2 dependent. Transcriptional activity of p53 in response to RITA required the presence of Chk2. A partial rescue of apoptosis observed in Noxa knockdown cells emphasized the relevance of p53 transcriptional activity for RITA-induced apoptosis. In addition, we observed an early p53- and Chk2-dependent block of DNA replication upon RITA treatment. Replicating cells seemed more prone to entering RITA-induced apoptosis. Furthermore, the RITA-induced DNA damage response, which was not a secondary effect of apoptosis induction, was strongly attenuated in cells lacking p53 or Chk2. In conclusion, we identified Chk2 as an essential mediator of the cellular responses to RITA.

  14. Antibacterial properties of the skin mucus of the freshwater fishes, Rita rita and Channa punctatus.

    Science.gov (United States)

    Kumari, U; Nigam, A K; Mitial, S; Mitial, A K

    2011-07-01

    The skin mucus of Rita rita and Channa punctatus was investigated to explore the possibilities of its antibacterial properties. Skin mucus was extracted in acidic solvents (0.1% trifluoroacetic acid and 3% acetic acid) and in triple distilled water (aqueous medium). The antibacterial activity of the mucus extracts was analyzed, using disc diffusion method, against five strains of bacteria--the Gram-positive Staphylococcus aureus and Micrococcus luteus; and the Gram negative Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi. In both Rita rita and Channa punctatus, the skin mucus extracted in acidic solvents as well as in aqueous medium show antibacterial activity against Staphylococcus aureus and Micrococcus luteus. Nevertheless, the activity is higher in acidic solvents than that in aqueous medium. The acidic mucus extracts of Rita rita, show antibacterial activity against Salmonella typhi as well. The results suggest that fish skin mucus have bactericidal properties and thus play important role in the protection of fish against the invasion of pathogens. Fish skin mucus could thus be regarded as a potential source of novel antibacterial components.

  15. Proteomic profiling of white muscle from freshwater catfish Rita rita.

    Science.gov (United States)

    Mohanty, Bimal Prasanna; Mitra, Tandrima; Banerjee, Sudeshna; Bhattacharjee, Soma; Mahanty, Arabinda; Ganguly, Satabdi; Purohit, Gopal Krishna; Karunakaran, Dhanasekar; Mohanty, Sasmita

    2015-06-01

    Muscle tissues contribute 34-48 % of the total body mass in fish. Proteomic analysis enables better understanding of the skeletal muscle physiology and metabolism. A proteome map reflects the general fingerprinting of the fish species and has the potential to identify novel proteins which could serve as biomarkers for many aspects of aquaculture including fish physiology and growth, flesh quality, food safety and aquatic environmental monitoring. The freshwater catfish Rita rita of the family Bagridae inhabiting the tropical rivers and estuaries is an important food fish with high nutritive value and is also considered a species of choice in riverine pollution monitoring. Omics information that could enhance utility of this species in molecular research is meager. Therefore, in the present study, proteomic analysis of Rita rita muscle has been carried out and functional genomics data have been generated. A reference muscle proteome has been developed, and 23 protein spots, representing 18 proteins, have been identified by MALDI-TOF/TOF-MS and LC-MS/MS. Besides, transcript information on a battery of heat shock proteins (Hsps) has been generated. The functional genomics information generated could act as the baseline data for further molecular research on this species.

  16. 27 CFR 9.162 - Sta. Rita Hills.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Sta. Rita Hills. 9.162.... Rita Hills. (a) Name. The name of the viticultural area described in this section is “Sta. Rita Hills”. For purposes of part 4 of this chapter, “Sta. Rita Hills” is a term of viticultural significance. (b...

  17. Til lykke eller Rita

    DEFF Research Database (Denmark)

    Agger, Gunhild

    2012-01-01

    Med Rita og Lykke har den satiriske sædekomedie fået en renæssance. Sædekomedien lever af at udstille normbrud og satirisere over menneskenes omgangsformer og kommunikation eller mangel på samme. Det er netop det, der sker i Rita og Lykke, hvor det outrerede eksponeres for at latterliggøres....

  18. Realizing the full potential of a RITA spectrometer

    DEFF Research Database (Denmark)

    Lefmann, K.; Niedermayer, C.; Abrahamsen, A.B.

    2006-01-01

    The “re-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion...... relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential...

  19. Realizing the full potential of a RITA spectrometer

    International Nuclear Information System (INIS)

    Lefmann, K.; Niedermayer, Ch.; Abrahamsen, A.B.; Bahl, C.R.H.; Christensen, N.B.; Jacobsen, H.S.; Larsen, T.L.; Haefliger, P.; Filges, U.; Ronnow, H.M.

    2006-01-01

    The 're-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential to increase the flux at the sample position by a factor 5

  20. Realizing the full potential of a RITA spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Lefmann, K. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: kim.lefmann@risoe.dk; Niedermayer, Ch. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Abrahamsen, A.B. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Bahl, C.R.H. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Christensen, N.B. [Riso National Laboratory, Frederiksborgvej 399, DK-4000 Roskilde (Denmark): Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Jacobsen, H.S. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen O (Denmark); Larsen, T.L. [Niels Bohr Institute, University of Copenhagen, DK-2100 Copenhagen O (Denmark); Haefliger, P. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Filges, U. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland); Ronnow, H.M. [Laboratory for Neutron Scattering, ETH-Zuerich and Paul Scherrer Institut, CH-5232 Villilgen (Switzerland)

    2006-11-15

    The 're-invented triple-axis spectrometer (RITA) concept has existed for a decade. Recent developments at RITA-2 at PSI, have revealed more of the potential of this instrument class. We demonstrate the performance of the multi-blade imaging mode, which has been applied e.g. to studies of dispersion relations and emphasize the power of this mode in combination with the low background of RITA-2. In addition, we present other ways of utilizing the position sensitive detector in a RITA instrument. Simulations of a planned upgrade of the guide-monochromator system at RITA-2 have shown a potential to increase the flux at the sample position by a factor 5.

  1. Hurricane Rita Poster (September 22, 2005)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Hurricane Rita poster. Multi-spectral image from NOAA-16 shows Hurricane Rita as a category-4 hurricane in the Gulf of Mexico on September 22, 2005. Poster size is...

  2. Morphological observation and length-weight relationship of critically endangered riverine catfish Rita rita (Hamilton).

    Science.gov (United States)

    Amin, M R; Mollah, M F A; Taslima, K; Muhammadullah

    2014-01-15

    The experiment was conducted to investigate the morphological status of the critically endangered riverine catfish Rita rita using morphometric and meristic traits. About 158 species of Rita were collected from the old Brahmaputra river in Mymensingh district and were studied in the laboratory of the Fisheries Biology and Genetics Department, Bangladesh Agricultural University. Measurement of length and weight of Rita were recorded by using measuring scale and electric balance respectively. Significant curvilinear relationship existed between total length and other morphometric characters and between head length and other characters of the head. Relationships between total length and various body measurements of the fish were highly significant (p < 0.01) except the relationship between total length and pelvic fin length of male fish (p < 0.05). In case of meristic characters-dorsal fin rays, pelvic fin rays, pectoral fin rays, anal fin rays, caudal fin rays, number of vertebrae and branchiostegal rays were found to be more or less similar except slight differences. The values of condition factors (k) in the total length body-weight relationships for female and male were found to be 0.41 and 0.38, respectively. The mean values of relative condition factors (kn) were 1.0 and 1.005 for female and male, respectively.

  3. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis.

    Science.gov (United States)

    Wang, Haihe; Chen, Guofu; Wang, Hongzhi; Liu, Chunbo

    2013-01-01

    RBP-J-interacting and tubulin-associated (RITA) is a novel RBP-J-interacting protein that downregulates Notch-mediated transcription. The current study focuses on the antitumor effect of RITA in human hepatocellular carcinoma (HCC) and aims to explore its molecular mechanism. Thirty paired HCC and adjacent non-tumoral liver samples were analyzed by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). RITA overexpression was induced by transfection of a pcDNA3.1-Flag-RITA plasmid into HepG2 cells. RITA knockdown was achieved by siRNA transfection. mRNA and protein expression of target genes were quantified by qRT-PCR and Western blotting, respectively. Cell proliferation and apoptosis were measured using MTT assay and flow cytometry. Our results demonstrate that adjacent nontumoral liver samples exhibited increased RITA expression compared to HCC tissues (p RITA levels were associated with tumor differentiation status. Overexpression of RITA suppressed cell proliferation and promoted early apoptosis, while its silencing promoted cell growth dramatically (p RITA overexpression upregulated p53 and reduced cyclin E levels, whereas silencing of RITA had the opposite effect on p53 and cyclin E expression. Our in vitro results represent the first evidence that RITA might suppress tumor growth and induce apoptosis in HCCs, and may be a potent antitumoral agent for HCC treatment that deserves further exploration.

  4. Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance.

    Science.gov (United States)

    Bu, Yiwen; Cai, Guoshuai; Shen, Yi; Huang, Chenfei; Zeng, Xi; Cao, Yu; Cai, Chuan; Wang, Yuhong; Huang, Dan; Liao, Duan-Fang; Cao, Deliang

    2016-12-28

    Inactivation of p53 occurs frequently in various cancers. RITA is a promising anticancer small molecule that dissociates p53-MDM2 interaction, reactivates p53 and induces exclusive apoptosis in cancer cells, but acquired RITA resistance remains a major drawback. This study found that the site-differential phosphorylation of nuclear factor-κB (NF-κB) RelA/p65 creates a barcode for RITA chemosensitivity in cancer cells. In naïve MCF7 and HCT116 cells where RITA triggered vast apoptosis, phosphorylation of RelA/p65 increased at Ser536, but decreased at Ser276 and Ser468; oppositely, in RITA-resistant cells, RelA/p65 phosphorylation decreased at Ser536, but increased at Ser276 and Ser468. A phosphomimetic mutation at Ser536 (p65/S536D) or silencing of endogenous RelA/p65 resensitized the RITA-resistant cells to RITA while the phosphomimetic mutant at Ser276 (p65/S276D) led to RITA resistance of naïve cells. In mouse xenografts, intratumoral delivery of the phosphomimetic p65/S536D mutant increased the antitumor activity of RITA. Furthermore, in the RITA-resistant cells ATP-binding cassette transporter ABCC6 was upregulated, and silencing of ABCC6 expression in these cells restored RITA sensitivity. In the naïve cells, ABCC6 delivery led to RITA resistance and blockage of p65/S536D mutant-induced RITA sensitivity. Taken together, these data suggest that the site-differential phosphorylation of RelA/p65 modulates RITA sensitivity in cancer cells, which may provide an avenue to manipulate RITA resistance. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.

    Science.gov (United States)

    Steinhäuser, K; Klöble, P; Kreis, N-N; Ritter, A; Friemel, A; Roth, S; Reichel, J M; Michaelis, J; Rieger, M A; Louwen, F; Oswald, F; Yuan, J

    2017-04-01

    Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signaling pathway. Intriguingly, deregulated RITA is involved in primary hepatocellular carcinoma and other malignant entities. We were interested in the potential molecular mechanisms behind its involvement. We show here that RITA binds to tubulin and localizes to various mitotic MT structures. RITA coats MTs and affects their structures in vitro as well as in vivo. Tumor cell lines deficient of RITA display increased acetylated α-tubulin, enhanced MT stability and reduced MT dynamics, accompanied by multiple mitotic defects, including chromosome misalignment and segregation errors. Re-expression of wild-type RITA, but not RITA Δtub ineffectively binding to tubulin, restores the phenotypes, suggesting that the role of RITA in MT modulation is mediated via its interaction with tubulin. Mechanistically, RITA interacts with tubulin/histone deacetylase 6 (HDAC6) and its suppression decreases the binding of the deacetylase HDAC6 to tubulin/MTs. Furthermore, the mitotic defects and increased MT stability are also observed in RITA -/- mouse embryonic fibroblasts. RITA has thus a novel role in modulating MT dynamics and its deregulation results in erroneous chromosome segregation, one of the major reasons for chromosome instability in tumor cells.

  6. Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin.

    Science.gov (United States)

    Wiegering, Armin; Matthes, Niels; Mühling, Bettina; Koospal, Monika; Quenzer, Anne; Peter, Stephanie; Germer, Christoph-Thomas; Linnebacher, Michael; Otto, Christoph

    2017-04-01

    Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA) is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by enhancing DNA damage signaling pathways. Therefore, we highlighted the antiproliferative response of RITA alone and in combination with 5FU or oxaliplatin in human CRC cells. A panel of long-term established CRC cell lines (n=9) including p53 wild-type, p53 mutant, and p53 null and primary patient-derived, low-passage cell lines (n=5) with different p53 protein status were used for this study. A substantial number of CRC cells with pronounced sensitivity to RITA (IC 50 RITA appeared independent of p53 status and was associated with an increase in antiproliferative response to 5FU and oxaliplatin, a transcriptional increase of p53 targets p21 and NOXA, and a decrease in MYC mRNA. The effect of RITA as an inducer of DNA damage was shown by a strong elevation of phosphorylated histone variant H2A.X, which was restricted to RITA-sensitive cells. Our data underline the primary effect of RITA, inducing DNA damage, and demonstrate the differential antiproliferative effect of RITA to CRC cells independent of p53 protein status. We found a substantial number of RITA-sensitive CRC cells within both panels of established CRC cell lines and primary patient-derived CRC cell lines (6/14) that provide a rationale for combining RITA with 5FU or

  7. RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles.

    Science.gov (United States)

    Pietkiewicz, Adrian L; Zhang, Yuqi; Rahimi, Marwa N; Stramandinoli, Michael; Teusner, Matthew; McAlpine, Shelli R

    2017-04-13

    The established cytotoxic agent RITA contains a thiophene-furan-thiophene backbone and two terminal alcohol groups. Herein we investigate the effect of using thiazoles as the backbone in RITA-like molecules and modifying the terminal groups of these trithiazoles, thereby generating 41 unique structures. Incorporating side chains with varied steric bulk allowed us to investigate how size and a stereocenter impacted biological activity. Subjecting compounds to growth inhibition assays on HCT-116 cells showed that the most potent compounds 7d , 7e , and 7h had GI 50 values of 4.4, 4.4, and 3.4 μM, respectively, versus RITA (GI 50 of 800 nM). Analysis of these compounds in apoptosis assays proved that 7d , 7e , and 7h were as effective as RITA at inducing apoptosis. Evaluating the impact of 7h on proteins targeted by RITA (p53, c-Myc, and Mcl-1) indicated that it acts via a different mechanism of action to that of RITA. RITA suppressed Mcl-1 protein via p53, whereas compound 7h suppressed Mcl-1 expression via an alternative mechanism independent of p53.

  8. Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless.

    Science.gov (United States)

    Brockmann, Birgit; Mastel, Helena; Oswald, Franz; Maier, Dieter

    2014-12-01

    Notch signalling mediates intercellular communication, which is effected by the transcription factor CSL, an acronym for vertebrate CBF1/RBP-J, Drosophila Suppressor of Hairless [Su(H)] and C. elegans Lag1. Nuclear import of CBF1/RBP-J depends on co-activators and co-repressors, whereas the export relies on RITA. RITA is a tubulin and CBF1/RBP-J binding protein acting as a negative regulator of Notch signalling in vertebrates. RITA protein is highly conserved in eumatazoa, but no Drosophila homologue was yet identified. In this work, the activity of human RITA in the fly was addressed. To this end, we generated transgenic flies that allow a tissue specific induction of human RITA, which was demonstrated by Western blotting and in fly tissues. Unexpectedly, overexpression of RITA during fly development had little phenotypic consequences, even when overexpressed simultaneously with either Su(H) or the Notch antagonist Hairless. We demonstrate the in vivo binding of human RITA to Su(H) and to tubulin by co-immune precipitation. Moreover, RITA and tubulin co-localized to some degree in several Drosophila tissues. Overall our data show that human RITA, albeit binding to Drosophila Su(H) and tubulin, cannot influence the Notch signalling pathway in the fly, suggesting that a nuclear export mechanism of Su(H), if existent in Drosophila, does not depend on RITA. © 2015 The Authors.

  9. Reactivating p53 and Inducing Tumor Apoptosis (RITA Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin

    Directory of Open Access Journals (Sweden)

    Armin Wiegering

    2017-04-01

    Full Text Available Colorectal carcinoma (CRC is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and inducing tumor apoptosis (RITA is described as an activator of wild-type and reactivator of mutant p53 function, resulting in elevated levels of p53 protein, cell growth arrest, and cell death. Additionally, it has been shown that RITA can induce DNA damage signaling. It is expected that the therapeutic benefits of 5FU and oxaliplatin can be increased by enhancing DNA damage signaling pathways. Therefore, we highlighted the antiproliferative response of RITA alone and in combination with 5FU or oxaliplatin in human CRC cells. A panel of long-term established CRC cell lines (n = 9 including p53 wild-type, p53 mutant, and p53 null and primary patient-derived, low-passage cell lines (n = 5 with different p53 protein status were used for this study. A substantial number of CRC cells with pronounced sensitivity to RITA (IC50< 3.0 μmol/l were identified within established (4/9 and primary patient-derived (2/5 CRC cell lines harboring wild-type or mutant p53 protein. Sensitivity to RITA appeared independent of p53 status and was associated with an increase in antiproliferative response to 5FU and oxaliplatin, a transcriptional increase of p53 targets p21 and NOXA, and a decrease in MYC mRNA. The effect of RITA as an inducer of DNA damage was shown by a strong elevation of phosphorylated histone variant H2A.X, which was restricted to RITA-sensitive cells. Our data underline the primary effect of RITA, inducing DNA damage, and demonstrate the differential antiproliferative effect of RITA to CRC cells independent of p53 protein status. We found a substantial number

  10. Looking at the future with Rita.

    Science.gov (United States)

    Bentivoglio, M

    2013-11-12

    This paper on Rita Levi-Montalcini (1909-2012), who received in 1986 the Nobel Prize in Physiology or Medicine for the discovery of nerve growth factor, focuses on aspects of her advocacy and her commitment to education in which she has been especially active in the last part of her long life. With passionate confidence on the capabilities of the aging brain (together with severe admonition against the pursuit of immortality), she encouraged contributions of senior citizens to the society. Always projected into the future, with enduring faith in the potential of young individuals, in education as a key to development, in the capabilities of women, in the importance of gender equality, Rita established in 2001 the Rita Levi-Montalcini Foundation for the education of African women. Her legacy on engagement for a better 'global village' should not be forgotten by the neuroscience community.

  11. Simulations and experiments on RITA-2 at PSI

    DEFF Research Database (Denmark)

    Klausen, S.N.; Lefmann, K.; McMorrow, D.F.

    2002-01-01

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray...

  12. Added flexibility in triple axis spectrometers: The two RITAs at Risø

    DEFF Research Database (Denmark)

    Lefmann, K.; McMorrow, D.F.; Rønnow, H.M.

    2000-01-01

    The cold-neutron triple-axis spectrometer RITA-I at Rise has been operational for about three years, and in the near future an improved version, RITA-2 will replace the existing triple-axis instrument TAS7. We review the performance of RITA-1 and the operation modes of its flexible secondary...... spectrometer, giving examples of a few key experiments, and describe the software developed for running it. Further, the design of the new RITA-2 instrument is presented. The two RITA spectrometers are compared with their sister instrument SPINS at NIST and with similar instruments planned elsewhere. (C) 2000...

  13. Serous goblet cells: the protein secreting cells in the oral cavity of a catfish, Rita rita (Hamilton, 1822) (Bagridae, Siluriformes).

    Science.gov (United States)

    Yashpal, Madhu; Mittal, Ajay Kumar

    2014-02-01

    Serous goblet cells in the oral epithelium of Rita rita are characterized by the presence of distinct eosinophilic granules occupying large parts of the cytoplasm. In R. rita, a range of histochemical results reveal that these cells are involved in proteinaceous secretions, and thus likely contribute to various functions analogous to those of mammalian saliva. The secretions of these cells have also been associated with specific functions and are discussed in relation to their physiological importance with special reference to their roles in lubrication, alteration in viscosity, various functions of mucus such as handling, maneuvering and driving of food items toward the esophagus, maintaining taste sensitivity and protection of the oral epithelium. In addition, the serous goblet cells may also be considered as the primary defensive cell of the oral epithelium of R. rita. The results significantly add to very limited set of literature on the serous goblet cells and provide noteworthy information on the mucous secretions in the oral cavity of fish. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. Retention of Displaced Students after Hurricanes Katrina and Rita

    Science.gov (United States)

    Coco, Joshua Christian

    2017-01-01

    The purpose of the study was to investigate the strategies that university leaders implemented to improve retention of displaced students in the aftermaths of Hurricanes Katrina and Rita. The universities that participated in this study admitted displaced students after Hurricanes Katrina and Rita. This study utilized a qualitative…

  15. RITA displays anti-tumor activity in medulloblastomas independent of TP53 status.

    Science.gov (United States)

    Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes H; Künkele, Annette

    2017-04-25

    Current therapy of medulloblastoma, the most common malignant brain tumor of childhood, achieves 40-70% survival. Secondary chemotherapy resistance contributes to treatment failure, where TP53 pathway dysfunction plays a key role. MDM2 interaction with TP53 leads to its degradation. Reactivating TP53 functionality using small-molecule inhibitors, such as RITA, to disrupt TP53-MDM2 binding may have therapeutic potential. We show here that RITA decreased viability of all 4 analyzed medulloblastoma cell lines, regardless of TP53 functional status. The decrease in cell viability was accompanied in 3 of the 4 medulloblastoma cell lines by accumulation of TP53 protein in the cells and increased CDKN1A expression. RITA treatment in mouse models inhibited medulloblastoma xenograft tumor growth. These data demonstrate that RITA treatment reduces medulloblastoma cell viability in both in vitro and in vivo models, and acts independently of cellular TP53 status, identifying RITA as a potential therapeutic agent to treat medulloblastoma.

  16. [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells].

    Science.gov (United States)

    He, Xiao-Yan; Feng, Xiao-Li; Song, Xin-Pei; Zeng, Huan-Chao; Cao, Zhong-Xu; Xiao, Wei-Wei; Zhang, Bao; Wu, Qing-Hua

    2016-10-20

    To observe the effect of RITA, a small molecule that targets p53, combined with temozolomide (TMZ) on proliferation, colony formation and apoptosis of human glioblastoma U87 cells and explore the underlying mechanism. Cultured U87 cells were treated with RITA (1, 5, 10, 20 µmol/L), TMZ, or RITA+TMZ (half dose) for 24, 48 or 72 h. MTS assay were used to detect the cell proliferation, and the cell proliferation rate and inhibitory rate were calculated. The effect of combined treatments was evaluated by the q value. The expressions of p53, p21 and other apoptosis-associated genes were detected by qRT-PCR and Western blotting; cell apoptosis was assayed using flow cytometry with Annexin V/PI double staining; colony formation of the cells was detected with crystal violet staining. MTS assay showed that RITA at the 4 doses more potently inhibited U87 cell viability than TMZ at 72 h (P=0.000) with inhibitory rates of 25.94%-41.38% and 3.84%-8.20%, respectively. RITA combined with TMZ caused a more significant inhibition of U87 cells (29.21%-52.11%) than RITA (PRITA+TMZ for 48 h resulted in q values exceeding 1.2 and showed an obvious synergistic effect of the drugs. Both RITA and TMZ, especially the latter, significantly increased the expressions of p53, p21, puma, and other apoptosis-associated genes to accelerate apoptosis and inhibit the growth and colony formation of U87 cells, and the effect was more obvious with a combined treatment. RITA inhibits the growth of human glioblastoma cells and enhance their sensitivity to TMZ by up-regulating p53 expression, and when combined, RITA and TMZ show a synergistic effect to cause a stronger cell inhibition.

  17. Interview: Rita Colwell

    OpenAIRE

    Alucozai, Milad

    2012-01-01

    Dr. Rita Colwell is a renowned microbiologist and infectious disease expert as well as a Purdue Alumna. She served as the 11th director of the National Science Foundation (NSF) from 1998 to 2004. Currently, she serves as the President and CEO of CosmosID and is a Distinguished Professor at both the University of Maryland and Johns Hopkins University School of Public Health.

  18. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

    Science.gov (United States)

    Chuang, Hui-Ching; Yang, Liang Peng; Fitzgerald, Alison L; Osman, Abdullah; Woo, Sang Hyeok; Myers, Jeffrey N; Skinner, Heath D

    2014-01-01

    TP53 is the most commonly mutated gene in head and neck cancer (HNSCC), with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis), a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1) inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC.

  19. Teaching: in light of Noel Gough's and Ajay Sharma's articles

    Science.gov (United States)

    Pouliot, Chantal

    2017-12-01

    In their articles, Ajay Sharma (Cult Stud Sci Educ, doi: 10.1007/s11422-017-9835-z, 2017) and Noel Gough (Cult Stud Sci Educ, doi: 10.1007/s11422-017-9834-0, 2017) shed light on the impact neoliberalism has on the teaching of science and suggest ways to ensure that science education remains critical and socially equitable. In this paper, I illustrate how their proposals influenced my instructional choices during the fall of 2016 in a course entitled Epistemology and Education.

  20. Simulations and experiments on RITA-2 at PSI

    International Nuclear Information System (INIS)

    Klausen, S.N.; Lefmann, K.; McMorrow, D.F.; Altorfer, F.; Janssen, S.; Luethy, M.

    2002-01-01

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray-tracing package McStas. The simulation results are compared to real experimental results obtained with a powder sample. Especially, the flux at the sample position and the resolution function of the spectrometer are investigated. (orig.)

  1. Simulations and experiments on RITA-2 at PSI

    Science.gov (United States)

    Klausen, S. N.; Lefmann, K.; McMorrow, D. F.; Altorfer, F.; Janssen, S.; Lüthy, M.

    The cold-neutron triple-axis spectrometer RITA-2 designed and built at Riso National Laboratory was installed at the neutron source SINQ at Paul Scherrer Institute in April/May 2001. In connection with the installation of RITA-2, computer simulations were performed using the neutron ray-tracing package McStas. The simulation results are compared to real experimental results obtained with a powder sample. Especially, the flux at the sample position and the resolution function of the spectrometer are investigated.

  2. Surface ultrastructure of the gill filaments and the secondary lamellae of the catfish, Rita rita, and the carp, Cirrhinus mrigala.

    Science.gov (United States)

    Kumari, Usha; Mittal, Swati; Mittal, Ajay Kumar

    2012-04-01

    Surface ultrastructures of gill filaments and secondary lamellae of Rita rita and Cirrhinus mrigala, inhabiting different ecological habitat, were investigated to unravel adaptive modifications. R. rita is a sluggish, bottom dwelling carnivorous catfish, which inhabits regions of river with accumulations of dirty water. It retains its viability for long time if taken out of water. C. mrigala is an active bottom dwelling Indian major carp, which lives in relatively clean water and dies shortly after taken out of water. In R. rita, gill septa between gill filaments are reduced. Microridges on epithelial cells covering gill filaments are often continuous and arranged concentrically. Secondary lamellae are extensive. The epithelium appears corrugated, show irregular elevations and shallow depressions, and microridges on epithelial cells appear fragmented. In C. mrigala, in contrast, the gill septa are extensive. Microridges on epithelial cells covering gill filaments are fragmented. Secondary lamellae are less extensive. The epithelium appears smooth and microridges on epithelial cells are relatively inconspicuous. These differences have been considered adaptive modification in relation to habit and ecological niches inhabited by two fish species. Presence of mucous goblet cells on gill filaments is discussed in relation to their functions including precipitation of the sediments and preventing clogging of gill filaments. Infrequent mucous goblet cells in the epithelium of secondary lamellae in two fish species are considered an adaptation, minimizing thickness of the epithelium to reduce barrier between blood and water for favoring gasses exchange with increased efficiency. Copyright © 2011 Wiley-Liss, Inc.

  3. The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells.

    Directory of Open Access Journals (Sweden)

    Hui-Ching Chuang

    Full Text Available TP53 is the most commonly mutated gene in head and neck cancer (HNSCC, with mutations being associated with resistance to conventional therapy. Restoring normal p53 function has previously been investigated via the use of RITA (reactivation of p53 and induction of tumor cell apoptosis, a small molecule that induces a conformational change in p53, leading to activation of its downstream targets. In the current study we found that RITA indeed exerts significant effects in HNSCC cells. However, in this model, we found that a significant outcome of RITA treatment was accelerated senescence. RITA-induced senescence in a variety of p53 backgrounds, including p53 null cells. Also, inhibition of p53 expression did not appear to significantly inhibit RITA-induced senescence. Thus, this phenomenon appears to be partially p53-independent. Additionally, RITA-induced senescence appears to be partially mediated by activation of the DNA damage response and SIRT1 (Silent information regulator T1 inhibition, with a synergistic effect seen by combining either ionizing radiation or SIRT1 inhibition with RITA treatment. These data point toward a novel mechanism of RITA function as well as hint to its possible therapeutic benefit in HNSCC.

  4. Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA.

    Science.gov (United States)

    Zhao, Carolyn Y; Grinkevich, Vera V; Nikulenkov, Fedor; Bao, Wenjie; Selivanova, Galina

    2010-05-01

    Expression of mutant p53 correlates with poor prognosis in many tumors, therefore strategies aimed at reactivation of mutant p53 are likely to provide important benefits for treatment of tumors that are resistant to chemotherapy and radiotherapy. We have previously identified and characterized a small molecule RITA which binds p53 and induces a conformational change which prevents the binding of p53 to several inhibitors, including its own destructor MDM2. In this way, RITA rescues the tumor suppression function of wild type p53. Here, we demonstrate that RITA suppressed the growth and induced apoptosis in human tumor cell lines of a diverse origin carrying mutant p53 proteins. RITA restored transcriptional transactivation and transrepression function of several hot spot p53 mutants. The ability of RITA to rescue the activity of different p53 mutants suggests its generic mechanism of action. Thus, RITA is a promising lead for the development of anti-cancer drugs that reactivate the tumor suppressor function of p53 in cancer cells irrespective whether they express mutant or wild type p53.

  5. Rita Kirke: "Taimed on minu head õpetajad ja toetajad" / Rita Kirke

    Index Scriptorium Estoniae

    Kirke, Rita

    2006-01-01

    Elukutselisi aiakujundajaid tutvustavas sarjas vastab küsimustele läti aiakujundaja Rita Kirke. R. Kirkest, tema tähtsamad tööd. R. Kirke endast, oma õpetajatest, oma aiast ja töödest, Läti oludesse sobivast ja tüüpilisest Läti aiast, koostööst klientidega, lemmiktaimedest, taimede kättesaadavusest Lätis jpm. Ill.: R. Kirke portreefoto, 6 ill. tema töödest

  6. Exp-function method for constructing exact solutions of Sharma-Tasso-Olver equation

    International Nuclear Information System (INIS)

    Erbas, Baris; Yusufoglu, Elcin

    2009-01-01

    In this paper we use the Exp-function method for the analytic treatment of Sharma-Tasso-Olver equation. New solitonary solutions are formally derived. Change of parameters, which drastically changes the characteristics of the equations, is examined. It is shown that the Exp-function method provides a powerful mathematical tool for solving high-dimensional nonlinear evolutions in mathematical physics. The proposed schemes are reliable and manageable.

  7. Ang Rita 1

    OpenAIRE

    Loomis, Molly

    2012-01-01

    .wav and .mp3 versions of audio file Ang Rita describes in Sherpa difference aspects of his life as a yak herder and yak herding culture. Tape includes native names for yak, birth and death ceremonies; castration practices; differences between Sherpa and Tibetan customs regarding yaks; herding yaks as a child; herding calls; interactions with wolves; grazing practices; concerns about decline of yak herding and the environmental consequences; the future of yak herding; famous yak herders; t...

  8. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

    Science.gov (United States)

    Wacker, Stephan Armin; Alvarado, Cristobal; von Wichert, Götz; Knippschild, Uwe; Wiedenmann, Jörg; Clauss, Karen; Nienhaus, Gerd Ulrich; Hameister, Horst; Baumann, Bernd; Borggrefe, Tilman; Knöchel, Walter; Oswald, Franz

    2011-01-05

    The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Ligand binding induces presenilin-dependent cleavage of the receptor and a subsequent nuclear translocation of the Notch intracellular domain (NICD). In the nucleus, NICD binds to the recombination signal sequence-binding protein J (RBP-J)/CBF-1 transcription factor to induce expression of Notch target genes. Here, we report the identification and functional characterization of RBP-J interacting and tubulin associated (RITA) (C12ORF52) as a novel RBP-J/CBF-1-interacting protein. RITA is a highly conserved 36 kDa protein that, most interestingly, binds to tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus. This shuttling RITA exports RBP-J/CBF-1 from the nucleus. Functionally, we show that RITA can reverse a Notch-induced loss of primary neurogenesis in Xenopus laevis. Furthermore, RITA is able to downregulate Notch-mediated transcription. Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting.

  9. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems.

    Science.gov (United States)

    Shin, Daiha; Kim, Eun Hye; Lee, Jaewang; Roh, Jong-Lyel

    2017-10-01

    Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53-MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major drawback. Here, we found a novel resistance mechanism of RITA treatment and an effective combined treatment to overcome RITA resistance in head and neck cancer (HNC) cells. The effects of RITA and 3-methyladenine (3-MA) were tested in different HNC cell lines, including cisplatin-resistant and acquired RITA-resistant HNC cells. The effects of each drug alone and in combination were assessed by measuring cell viability, apoptosis, cell cycle, glutathione, reactive oxygen species, protein expression, genetic inhibition of p62 and Nrf2, and a mouse xenograft model of cisplatin-resistant HNC. RITA induced apoptosis of HNC cells at different levels without significantly inhibiting normal cell viability. Following RITA treatment, RITA-resistant HNC cells exhibited a sustained expression of other autophagy-related proteins, overexpressed p62, and displayed activation of the Keap1-Nrf2 antioxidant pathway. The autophagy inhibitor 3-MA sensitized resistant HNC cells to RITA treatment via the dual inhibition of molecules related to the autophagy and antioxidant systems. Silencing of the p62 gene augmented the combined effects. The effective antitumor activity of RITA plus 3-MA was also confirmed in vivo in mouse xenograft models transplanted with resistant HNC cells, showing increased oxidative stress and DNA damage. The results indicate that RITA plus 3-MA can help overcome RITA resistance in HNC cells. This study revealed a novel RITA resistant mechanism associated with the sustained induction of autophagy, p62 overexpression, and Keap1-Nrf2 antioxidant system activation. The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual

  10. Prognostic impact of RITA expression in patients with anal squamous cell carcinoma treated with chemoradiotherapy.

    Science.gov (United States)

    Rödel, Franz; Steinhäuser, Kerstin; Kreis, Nina-Naomi; Friemel, Alexandra; Martin, Daniel; Wieland, Ulrike; Rave-Fränk, Margret; Balermpas, Panagiotis; Fokas, Emmanouil; Louwen, Frank; Rödel, Claus; Yuan, Juping

    2018-02-01

    RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signalling pathway and its deregulation is involved in the pathogenesis of several tumour entities. RITA's impact on the response of anal squamous cell carcinoma (SCC) to anticancer treatment, however, remains elusive. In our retrospective study immunohistochemical evaluation of RITA was performed on 140 pre-treatment specimens and was correlated with clinical and histopathologic characteristics and clinical endpoints cumulative incidence of local control (LC), distant recurrence (DC), disease-free survival (DFS) and overall survival (OS). We observed significant inverse correlations between RITA expression and tumour grading, the levels of HPV-16 virus DNA load, CD8 (+) tumour infiltrating lymphocytes and programmed death protein (PD-1) immunostaining. In univariate analyses, elevated levels of RITA expression were predictive for decreased local control (p = 0.001), decreased distant control (p = 0.040), decreased disease free survival (p = 0.001) and overall survival (p RITA expression remained significant for decreased local control (p = 0.009), disease free survival (p = 0.032) and overall survival (p = 0.012). These data indicate that elevated levels of pretreatment RITA expression are correlated with unfavourable clinical outcome in anal carcinoma treated with concomitant chemoradiotherapy. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis.

    Science.gov (United States)

    Kazemi, Ahmad; Safa, Majid; Shahbazi, Atefeh

    2011-07-01

    The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Here, we used small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) to sensitize leukemic NALM-6 cells to doxorubicin by upregulating p53 protein. RITA alone effectively inhibited NALM-6 cells viability in dose-dependent manner as measured by 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay and induced apoptosis as evaluated by flow cytometry, whereas RITA in combination with doxorubicin enhanced NALM-6 cells to doxorubicin-sensitivity and promoted doxorubicin induced apoptosis. Levels of p53 protein and its proapoptotic target genes, quantified by western blot and real-time PCR respectively, showed that expression of p53 was significantly increased after RITA treatment. Using p53 inhibitors PFT-alpha and PFT-mu it was shown that p53-mediated apoptosis induced by RITA can be regulated by both p53-transcription-dependent and -independent pathways. Moreover, RITA-induced apoptosis was accompanied by the activation of caspase-3 and PARP cleavage. Therefore, exploiting synergistic effects between RITA and chemotherapeutics might be an effective clinical strategy for leukemia chemotherapy.

  12. Rita Bottoms: Polyartist Librarian

    OpenAIRE

    Bottoms, Rita; Reti, Irene; Regional History Project, UCSC Library

    2005-01-01

    Project Director Irene Reti conducted fourteen hours of interviews with Rita Bottoms, Head of Special Collections at the University Library, UC Santa Cruz, shortly before her retirement in March 2003. This oral history provides a vivid and intimate look at thirty-seven years behind the scenes in the library's Special Collections. For thirty-seven years Bottoms dedicated herself to collecting work by some of the most eminent writers and photographers of the twentieth century, includin...

  13. The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer.

    Science.gov (United States)

    Roh, Jong-Lyel; Ko, Jung Ho; Moon, Soo Jin; Ryu, Chang Hwan; Choi, Jun Young; Koch, Wayne M

    2012-12-01

    We evaluated whether the restoration of p53 function by the p53-reactivating small molecule RITA (reactivation of p53 and induction of tumor cell apoptosis enhances cisplatin-induced cytotoxicity and apoptosis in head-and-neck cancer (HNC). RITA induced prominent accumulation and reactivation of p53 in a wild-type TP53-bearing HNC cell line. RITA showed maximal growth suppression in tumor cells showing MDM2-dependent p53 degradation. RITA promoted apoptosis in association with upregulation of p21, BAX, and cleaved caspase-3; notably, the apoptotic response was blocked by pifithrin-α, demonstrating its p53 dependence. With increasing concentrations, RITA strongly induced apoptosis rather than G2-phase arrest. In combination therapy, RITA enhanced cisplatin-induced growth inhibition and apoptosis of HNC cells invitro and in vivo. Our data suggest that the restoration of p53 tumor-suppressive function by RITA enhances the cytotoxicity and apoptosis of cisplatin, an action that may offer an attractive strategy for treating HNC. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  14. Krimmi-Rita juubelituur Eestimaal / Enda Trubok

    Index Scriptorium Estoniae

    Trubok, Enda

    2010-01-01

    Kontši-Savva ehk Krasnodarka küla eesti seltsi esinaisel Rita Kadilkinal (neiupõlvenimi Kuusk), kelle esivanemad 1862. aastal Järvamaalt – Albu vallast – Krimmi paremaid maid otsima läksid, täitus septembris 70 eluaastat, mille puhul otsustaski ta Eestisse tulla

  15. Residual power series method for fractional Sharma-Tasso-Olever equation

    Directory of Open Access Journals (Sweden)

    Amit Kumar

    2016-02-01

    Full Text Available In this paper, we introduce a modified analytical approximate technique to obtain solution of time fractional Sharma-Tasso-Olever equation. First, we present an alternative framework of the Residual power series method (RPSM which can be used simply and effectively to handle nonlinear fractional differential equations arising in several physical phenomena. This method is basically based on the generalized Taylor series formula and residual error function. A good result is found between our solution and the given solution. It is shown that the proposed method is reliable, efficient and easy to implement on all kinds of fractional nonlinear problems arising in science and technology.

  16. Ambient Assisted Living and ageing: preliminary results of RITA project.

    Science.gov (United States)

    Aquilano, Michela; Cavallo, Filippo; Bonaccorsi, Manuele; Esposito, Raffaele; Rovini, Erika; Filippi, Massimo; Esposito, Dario; Dario, Paolo; Carrozza, Maria Chiara

    2012-01-01

    The ageing of population is a social phenomenon that most of worldwide countries are facing. They are, and will be even more in the future, indeed trying to find solutions for improving quality of life of their elderly citizens. The project RITA wants to demonstrate that an update of the current socio-medical services with an Ambient Assisted Living (AAL) approach could improve the service efficiency and the quality of life of both elderly and caregiver. This paper presents the preliminary results obtained in RITA.

  17. Conversacion sobre "Tres tristes tigres". Una entrevista de Rita Guibert (A Conversation about "Three Sad Tigers". An Interview with Rita Guibert)

    Science.gov (United States)

    Cabrera Infante, Guillermo

    1971-01-01

    Interview took place in London, England, on October 5, 1970 between Cuban writer Guillermo Cabrera Infante and journalist Rita Guibert. Special issue dedicated to contemporary Spanish American literature. (DS)

  18. Reflection on Lessons Learned: An Analysis of the Adverse Outcomes Observed During the Hurricane Rita Evacuation.

    Science.gov (United States)

    Baker, Karen

    2018-02-01

    In September 2005, nearly 3.7 million people evacuated the Texas coastline in advance of Hurricane Rita's landfall, making the event the largest emergency evacuation in US history. The Rita evacuation underscored the importance of planning for domestic mass-evacuation events, as the evacuation itself led to over 100 of the at least 119 deaths attributed to the storm. In the days preceding Rita's landfall, several cascading, interrelated circumstances precipitated such adverse outcomes. This article explores the series of events leading up to the evacuation's poor outcomes, the response following Rita to amend evacuation plans, and how Texas successfully implemented these changes during later storms to achieve better outcomes. (Disaster Med Public Health Preparedness. 2018;12:115-120).

  19. Thomas Bang

    DEFF Research Database (Denmark)

    Petersen, Anne Ring; Bogh, Mikkel; Troelsen, Anders

    Monografi om kunstneren Thomas Bangs malerier, tegninger, skulpturer og installationer der følger hans virke fra de tidligste malerier fra begyndelsen af 1960erne til de seneste års store skupturinstallationer.......Monografi om kunstneren Thomas Bangs malerier, tegninger, skulpturer og installationer der følger hans virke fra de tidligste malerier fra begyndelsen af 1960erne til de seneste års store skupturinstallationer....

  20. Status of the RITA - experiment on EURECA. [Radio Frequency Ion Thrustor Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Bassner, H.; Berg, H.P.; Birner, W.; Bartoli, C.; Trippi, A.

    1987-01-01

    The radiofrequency ion thruster assembly (RITA) is currently built as a flight experiment which shall be flown on the European retrievable carrier (Eureca I). This test flight shall verify the operational use of this electric propulsion system in space by demonstration of operation, lifetime and reliability. For this purpose the RITA experiment has been adapted to meet the specific constraints imposed by the Eureca I spacecraft and by the Space Shuttle as the launcher; xenon gas will be used as the propellant and the experiment will be operated automatically by means of a dedicated on-board microcomputer system. According to the delay in launches by the Space Shuttle the launch date has been postponed from March 1988 to 1991/92. Therefore the total Eureca program has been extended, which also influenced the RITA time schedule.

  1. IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells.

    Science.gov (United States)

    Di Conza, Giusy; Buttarelli, Marianna; Monti, Olimpia; Pellegrino, Marsha; Mancini, Francesca; Pontecorvi, Alfredo; Scotlandi, Katia; Moretti, Fabiola

    2012-06-01

    Ewing sarcoma is one of the most frequent bone cancers in adolescence. Although multidisciplinary therapy has improved the survival rate for localized tumors, a critical step is the development of new drugs to improve the long-term outcome of recurrent and metastatic disease and to reduce side effects of conventional therapy. Here, we show that the small molecule reactivation of p53 and induction of tumor cell apoptosis (RITA, NSC652287) is highly effective in reducing growth and tumorigenic potential of Ewing sarcoma cell lines. These effects occur both in the presence of wt-p53 as well as of mutant or truncated forms of p53, or in its absence, suggesting the presence of additional targets in this tumor histotype. Further experiments provided evidence that RITA modulates an important oncogenic mark of these cell lines, insulin-like growth factor receptor 1 (IGF-1R). Particularly, RITA causes downregulation of IGF-1R protein levels. MDM2 degradative activity is involved in this phenomenon. Indeed, inhibition of MDM2 function by genetic or pharmacologic approaches reduces RITA sensitivity of Ewing sarcoma cell lines. Overall, these data suggest that in the cell context of Ewing sarcoma, RITA may adopt additional mechanism of action besides targeting p53, expanding its field of application. Noteworthy, these results envisage the promising utilization of RITA or its derivative as a potential treatment for Ewing sarcomas. ©2012 AACR

  2. Lightning and radar observations of hurricane Rita landfall

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, Bradley G [Los Alamos National Laboratory; Suszcynsky, David M [Los Alamos National Laboratory; Hamlin, Timothy E [Los Alamos National Laboratory; Jeffery, C A [Los Alamos National Laboratory; Wiens, Kyle C [TEXAS TECH U.; Orville, R E [TEXAS A& M

    2009-01-01

    Los Alamos National Laboratory (LANL) owns and operates an array of Very-Low Frequency (VLF) sensors that measure the Radio-Frequency (RF) waveforms emitted by Cloud-to-Ground (CG) and InCloud (IC) lightning. This array, the Los Alamos Sferic Array (LASA), has approximately 15 sensors concentrated in the Great Plains and Florida, which detect electric field changes in a bandwidth from 200 Hz to 500 kHz (Smith et al., 2002). Recently, LANL has begun development of a new dual-band RF sensor array that includes the Very-High Frequency (VHF) band as well as the VLF. Whereas VLF lightning emissions can be used to deduce physical parameters such as lightning type and peak current, VHF emissions can be used to perform precise 3d mapping of individual radiation sources, which can number in the thousands for a typical CG flash. These new dual-band sensors will be used to monitor lightning activity in hurricanes in an effort to better predict intensification cycles. Although the new LANL dual-band array is not yet operational, we have begun initial work utilizing both VLF and VHF lightning data to monitor hurricane evolution. In this paper, we present the temporal evolution of Rita's landfall using VLF and VHF lightning data, and also WSR-88D radar. At landfall, Rita's northern eyewall experienced strong updrafts and significant lightning activity that appear to mark a transition between oceanic hurricane dynamics and continental thunderstorm dynamics. In section 2, we give a brief overview of Hurricane Rita, including its development as a hurricane and its lightning history. In the following section, we present WSR-88D data of Rita's landfall, including reflectivity images and temporal variation. In section 4, we present both VHF and VLF lightning data, overplotted on radar reflectivity images. Finally, we discuss our observations, including a comparison to previous studies and a brief conclusion.

  3. Algo sobre a Europa: Thomas More

    OpenAIRE

    Coelho, Rui Pina

    2005-01-01

    Crítica de teatro / Thomas More / William Shakespeare / Anthony Munday / Robert Delamere / Royal Shakespeare Company ABSTRACT - Review of the theatre performance Thomas More, by Anthony Munday, Henry Chettle, Thomas Dekker, Thomas Heywood and William Shakespeare, directed by Robert Delamere, Royal Shakespeare Company (2005).

  4. 75 FR 14442 - Federal Travel Regulation (FTR); Relocation Allowances-Relocation Income Tax Allowance (RITA) Tables

    Science.gov (United States)

    2010-03-25

    ... GENERAL SERVICES ADMINISTRATION [GSA Bulletin FTR 10-04] Federal Travel Regulation (FTR); Relocation Allowances-- Relocation Income Tax Allowance (RITA) Tables AGENCY: Office of Governmentwide Policy... (73 FR 35952) specifying that GSA would no longer publish the RITA tables found in 41 CFR Part 301-17...

  5. jijimon k thomas

    Indian Academy of Sciences (India)

    JIJIMON K THOMAS. Articles written in Bulletin of Materials Science. Volume 40 Issue 6 October 2017 pp 1171-1178. Enhanced infrared transmission characteristics of microwave-sintered Y$_2$O$_3$–MgO nanocomposite · C T MATHEW SAM SOLOMON JACOB KOSHY JIJIMON K THOMAS · More Details Abstract ...

  6. Land Area Change and Fractional Water Maps in the Chenier Plain, Louisiana, following Hurricane Rita (2005)

    Science.gov (United States)

    Palaseanu-Lovejoy, Monica; Kranenburg, Christine J.; Brock, John C.

    2010-01-01

    In this study, we estimated the changes in land and water coverage of a 1,961-square-kilometer (km2) area in Louisiana's Chenier Plain. The study area is roughly centered on the Sabine National Wildlife Refuge, which was impacted by Hurricane Rita on September 24, 2005. The objective of this study is twofold: (1) to provide pre- and post-Hurricane Rita moderate-resolution (30-meter (m)) fractional water maps based upon multiple source images, and (2) to quantify land and water coverage changes due to Hurricane Rita.

  7. 75 FR 7467 - Gary E. Hall and Rita C. Hall; Notice of Application Accepted for Filing With the Commision...

    Science.gov (United States)

    2010-02-19

    ... Rita C. Hall; Notice of Application Accepted for Filing With the Commision, Soliciting Motions To.... Project No.: 13652-000. c. Date filed: January 11, 2010. d. Applicant: Gary E. Hall and Rita C. Hall. e... Policies Act of 1978, 16 U.S.C. 2705, 2708. h. Applicant Contact: Mr. Gary E. Hall and Ms. Rita C. Hall, P...

  8. 78 FR 7663 - SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-02-04

    ... 1625-AA08 SLR; 2013 International Rolex Regatta; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... special local regulations on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during... 5 p.m., Monday through Friday, except federal holidays. The telephone number is 202-366-9329. See...

  9. Positional stabilization of communications satellites - The RITA ion propulsion system is ready for commercial use

    Science.gov (United States)

    The radiofrequency ion thruster assembly (RITA) intended for service aboard the new Artemis communications satellite will operate for three hours twice a day, in order to furnish orbital position adjustments that keep antennas accurately pointed toward the earth. These engines are, despite such frequent and sustained use, projected to eject no more than 30 kG of Xe over the course of a decade. RITA operation is also extremely reliable and, due to its very low propellant consumption, is the basis of a long satellite service life. RITA will be among the 15 experiments that are to be performed by ESA's Eureca research satellite.

  10. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

    Science.gov (United States)

    Saha, Manujendra N; Jiang, Hua; Yang, Yijun; Zhu, Xiaoyun; Wang, Xiaoming; Schimmer, Aaron D; Qiu, Lugui; Chang, Hong

    2012-01-01

    The low frequency of p53 alterations e.g., mutations/deletions (∼10%) in multiple myeloma (MM) makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK) signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP) analysis showed that activated c-Jun binds to the activator protein-1 (AP-1) binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA) against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with JNK

  11. Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

    Directory of Open Access Journals (Sweden)

    Manujendra N Saha

    Full Text Available The low frequency of p53 alterations e.g., mutations/deletions (∼10% in multiple myeloma (MM makes this tumor type an ideal candidate for p53-targeted therapies. RITA is a small molecule which can induce apoptosis in tumor cells by activating the p53 pathway. We previously showed that RITA strongly activates p53 while selectively inhibiting growth of MM cells without inducing genotoxicity, indicating its potential as a drug lead for p53-targeted therapy in MM. However, the molecular mechanisms underlying the pro-apoptotic effect of RITA are largely undefined. Gene expression analysis by microarray identified a significant number of differentially expressed genes associated with stress response including c-Jun N-terminal kinase (JNK signaling pathway. By Western blot analysis we further confirmed that RITA induced activation of p53 in conjunction with up-regulation of phosphorylated ASK-1, MKK-4 and c-Jun. These results suggest that RITA induced the activation of JNK signaling. Chromatin immunoprecipitation (ChIP analysis showed that activated c-Jun binds to the activator protein-1 (AP-1 binding site of the p53 promoter region. Disruption of the JNK signal pathway by small interfering RNA (siRNA against JNK or JNK specific inhibitor, SP-600125 inhibited the activation of p53 and attenuated apoptosis induced by RITA in myeloma cells carrying wild type p53. On the other hand, p53 transcriptional inhibitor, PFT-α or p53 siRNA not only inhibited the activation of p53 transcriptional targets but also blocked the activation of c-Jun suggesting the presence of a positive feedback loop between p53 and JNK. In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Our study unveils a previously undescribed mechanism of RITA-induced p53-mediated apoptosis through JNK signaling pathway and provides the rationale for combination of p53 activating drugs with

  12. Combined VLF and VHF lightning observations of Hurricane Rita landfall

    Science.gov (United States)

    Henderson, B. G.; Suszcynsky, D. M.; Wiens, K. C.; Hamlin, T.; Jeffery, C. A.; Orville, R. E.

    2009-12-01

    Hurricane Rita displayed abundant lightning in its northern eyewall as it made landfall at 0740 UTC 24 Sep 2005 near the Texas/Louisiana border. For this work, we combined VHF and VLF lightning data from Hurricane Rita, along with radar observations from Gulf Coast WSR-88D stations, for the purpose of demonstrating the combined utility of these two spectral regions for hurricane lightning monitoring. Lightning is a direct consequence of the electrification and breakdown processes that take place during the convective stages of thunderstorm development. As Rita approached the Gulf coast, the VHF lightning emissions were distinctly periodic with a period of 1.5 to 2 hours, which is consistent with the rotational period of hurricanes. VLF lightning emissions, measured by LASA and NLDN, were present in some of these VHF bursts but not all of them. At landfall, there was a significant increase in lightning emissions, accompanied by a significant convective surge observed in radar. Furthermore, VLF and VHF lightning source heights clearly increase as a function of time. The evolution of the IC/CG ratio is consistent with that seen in thunderstorms, showing a dominance of IC activity during storm development, followed by an increase in CG activity at the storm’s peak. The periodic VHF lightning events are correlated with increases in convective growth (quantified by the volume of radar echo >40 dB) above 7 km altitude. VLF can discriminate between lightning types, and in the LASA data, Rita landfall lightning activity was dominated by Narrow Bi-polar Events (NBEs)—high-energy, high-altitude, compact intra-cloud discharges. The opportunity to locate NBE lightning sources in altitude may be particularly useful in quantifying the vertical extent (strength) of the convective development and in possibly deducing vertical charge distributions.

  13. Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes.

    Science.gov (United States)

    Tabaja, Nassif; Yuan, Zhenyu; Oswald, Franz; Kovall, Rhett A

    2017-06-23

    The Notch pathway is a cell-to-cell signaling mechanism that is essential for tissue development and maintenance, and aberrant Notch signaling has been implicated in various cancers, congenital defects, and cardiovascular diseases. Notch signaling activates the expression of target genes, which are regulated by the transcription factor CSL (CBF1/RBP-J, Su(H), Lag-1). CSL interacts with both transcriptional corepressor and coactivator proteins, functioning as both a repressor and activator, respectively. Although Notch activation complexes are relatively well understood at the structural level, less is known about how CSL interacts with corepressors. Recently, a new RBP-J (mammalian CSL ortholog)-interacting protein termed RITA has been identified and shown to export RBP-J out of the nucleus, thereby leading to the down-regulation of Notch target gene expression. However, the molecular details of RBP-J/RITA interactions are unclear. Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map the binding regions necessary for RBP-J·RITA complex formation, and determine the X-ray structure of the RBP-J·RITA complex bound to DNA. To validate the structure and glean more insights into function, we tested structure-based RBP-J and RITA mutants with biochemical/cellular assays and isothermal titration calorimetry. Whereas our structural and biophysical studies demonstrate that RITA binds RBP-J similarly to the RAM (RBP-J-associated molecule) domain of Notch, our biochemical and cellular assays suggest that RITA interacts with additional regions in RBP-J. Taken together, these results provide molecular insights into the mechanism of RITA-mediated regulation of Notch signaling, contributing to our understanding of how CSL functions as a transcriptional repressor of Notch target genes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

    Directory of Open Access Journals (Sweden)

    Daiha Shin

    2017-10-01

    Condensed abstract: This study revealed a novel RITA resistant mechanism associated with the sustained induction of autophagy, p62 overexpression, and Keap1-Nrf2 antioxidant system activation. The combined treatment of RITA with the autophagy inhibitor 3-methyladenine overcomes RITA resistance via dual inhibition of autophagy and antioxidant systems in vitro and in vivo.

  15. 44 CFR 206.209 - Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major...

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Arbitration for Public Assistance determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR... determinations related to Hurricanes Katrina and Rita (Major disaster declarations DR-1603, DR-1604, DR-1605, DR...

  16. 78 FR 16211 - Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-03-14

    ... 1625-AA00 Safety Zone, Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S. Virgin Islands... establish a temporary safety zone on the waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands... through Friday, except federal holidays. The telephone number is 202-366-9329. See the ``Public...

  17. 78 FR 23489 - Safety Zone; V.I. Carnival Finale, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-19

    ... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the V.I. Carnival Finale, a... through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this... event. The event will be held on the waters of St. Thomas Harbor, St. Thomas, U. S. Virgin Islands...

  18. Letter from Thomas Moran to Ferdinand Hayden and Paintings by Thomas Moran

    Science.gov (United States)

    Potter, Lee Ann; Eder, Elizabeth K.; Hussey, Michael

    2012-01-01

    Medical doctor and geologist Dr. Ferdinand Vandiveer Hayden selected more than 30 scientists, technical personnel, and artists, including photographer William Henry Jackson and painter Thomas Moran, to join the survey of the Yellowstone region in northwest Wyoming territory. Thomas Moran was an accomplished artist when he joined the survey to…

  19. How Schools Responded to Student Mental Health Needs Following Hurricanes Katrina and Rita. Fact Sheet

    Science.gov (United States)

    RAND Corporation, 2007

    2007-01-01

    This fact sheet summarizes a study that examined how schools in the U.S. Gulf Coast region perceived the mental health needs of students after Hurricanes Katrina and Rita and how schools responded. According to the report, despite strong initial efforts to support the mental health needs of students displaced by Hurricanes Katrina and Rita, many…

  20. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.

    Science.gov (United States)

    Weilbacher, A; Gutekunst, M; Oren, M; Aulitzky, W E; van der Kuip, H

    2014-07-10

    Significant advances have been made in the development of small molecules blocking the p53/MDM2 interaction. The Mdm2 inhibitor Nutlin-3 is restricted to tumors carrying wtp53. In contrast, RITA, a compound that binds p53, has recently been shown also to restore transcriptional functions of mtp53. As more than 50% of solid tumors carry p53 mutations, RITA promises to be a more effective therapeutic strategy than Nutlin-3. We investigated effects of RITA on apoptosis, cell cycle and induction of 45 p53 target genes in a panel of 14 cell lines from different tumor entities with different p53 status as well as primary lymphocytes and fibroblasts. Nine cell strains expressed wtp53, four harbored mtp53, and three were characterized by the loss of p53 protein. A significant induction of cell death upon RITA was observed in 7 of 16 cell lines. The nonmalignant cells in our panel were substantially less sensitive. We found that in contrast to Nultin-3, RITA is capable to induce cell death not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells. Importantly, whereas p53 has a central role for RITA-mediated effects in wtp53 cells, neither p53 nor p63 or p73 were essential for the RITA response in mtp53 or p53-null cells in our panel demonstrating that besides the known p53-dependent action of RITA in wtp53 cells, RITA can induce cell death also independently of p53 in cells harboring defective p53. We identified an important role of both p38 and JNK/SAPK for sensitivity to RITA in these cells leading to a typical caspase- and BAX/BAK-dependent mitochondrial apoptosis. In conclusion, our data demonstrate that RITA can induce apoptosis through p38 and JNK/SAPK not only in tumor cells harboring wtp53 and mtp53 but also in p53-null cells, making RITA an interesting tumor-selective drug.

  1. Children and Trauma: A Post-Katrina and Rita Response

    Science.gov (United States)

    Hebert, Barbara B.; Ballard, Mary B.

    2007-01-01

    Many children have struggled to cope with the traumatic experiences brought about by hurricanes Katrina and Rita. This article recounts how the authors intervened in the lives of children and families after the storms. (Contains 3 figures.)

  2. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents.

    Science.gov (United States)

    Michaelis, M; Rothweiler, F; Agha, B; Barth, S; Voges, Y; Löschmann, N; von Deimling, A; Breitling, R; Doerr, H Wilhelm; Rödel, F; Speidel, D; Cinatl, J

    2012-04-05

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. In addition, repeated adaptation of the RITA-adapted sub-line UKF-NB-3(r)RITA(10 μM) to nutlin-3 resulted in p53 mutations. The RITA-adapted UKF-NB-3 sub-lines displayed no or less pronounced resistance to vincristine, cisplatin, and irradiation than nutlin-3-adapted UKF-NB-3 sub-lines. Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3. Transcriptomic analyses indicated the RITA-adapted sub-lines to be more similar at the gene expression level to the parental UKF-NB-3 cells than nutlin-3-adapted UKF-NB-3 sub-lines, which correlates with the observed chemotherapy and irradiation sensitivity phenotypes. In conclusion, RITA-adapted cells retain functional p53, remain sensitive to nutlin-3, and display a less pronounced resistance phenotype than nutlin-3-adapted cells.

  3. Defining the Role of Public Health in Disaster Recovery: An Evaluation of State Public Health Planning Efforts

    Science.gov (United States)

    2013-03-01

    Brahmbhatt , Jennifer L. Chan, Edbert B. Hsu,Hani Mowafi, Thomas D. Kirsch, Asma Quereshi P. Gregg Greenough, “Public Health Preparedness of Post-Katrina...L. Chan, Edbert B. Hsu,Hani Mowafi, Thomas D. Kirsch, Asma Quereshi P. Gregg Greenough. “Public Health Preparedness of Post- Katrina and Rita

  4. 78 FR 16208 - Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    2013-03-14

    ... 1625-AA00 Safety Zone; V. I. Carnival Finale; St. Thomas Harbor; St. Thomas, U.S. Virgin Islands AGENCY... establish a safety zone on the waters of St. Thomas Harbor in St. Thomas, U. S. Virgin Islands during the V... between 9 a.m. and 5 p.m., Monday through Friday, except federal holidays. The telephone number is 202-366...

  5. The Recent Infection Testing Algorithm (RITA) in clinical practice: a survey of HIV clinicians in England and Northern Ireland.

    Science.gov (United States)

    Garrett, Nj; Lattimore, S; Gilbart, Vl; Aghaizu, A; Mensah, G; Tosswill, J; Murphy, G; Delpech, V

    2012-08-01

    In order to estimate HIV incidence among high-risk groups, in January 2009 the Health Protection Agency introduced the Recent Infection Testing Algorithm (RITA) in England and Northern Ireland (E&NI), currently the only regions to inform patients of RITA results. This survey of HIV specialists aimed to investigate the role of RITA in patient management and explore clinicians' views on its role in clinical practice and during partner notification. An online questionnaire was distributed to HIV specialists via the British HIV Association membership email list in February 2011. Forty-two HIV specialists from 32 HIV centres responded to the survey among 90 centres enrolled in the programme (response rate 36%). Testing for recent infection was considered standard of care by 83% of respondents, 80% felt confident in interpreting results and 92% discussed results with patients, particularly in the context of a possible HIV seroconversion illness (96%) or when deciding when to start antiretroviral therapy (70%). A third (36%) of specialists were initially concerned that RITA results may cause additional anxiety among patients; however, no adverse events were reported. The majority (90%) felt that results could assist with contact tracing by prioritizing patients with likely recent infection. However, only a few centres have currently incorporated RITA into their HIV partner notification protocols. RITA has been introduced into clinical practice with no reported patient adverse events. Access to results at centre level should be improved. National guidance regarding use of RITA as a tool for contact tracing is required. © 2012 British HIV Association.

  6. SISTEM INFORMASI DAN PENGOLAHAN DATA GAJI KARYAWAN PADA RITA PASARAYA KEBONDALEM PURWOKERTO

    Directory of Open Access Journals (Sweden)

    Nyoman Heddy Triyodanta

    2009-02-01

    Full Text Available Penelitian ini berjudul "Sistem Informasi dan Pengolahan Data GajiKaryawan pada Rita Pasaraya Kebondalem Purwokerto". Tujuan dari penelitian iniodalah untuk mengetahui prosedur sistem informasi pengolahan data gaji karynvanyang sedang berjalan atau sedang dipakai pada Rita Pasaraya KebondalemPurwoketo, yang masih dilakukan dengan proses manual dan pada akhirnyadirancang suatu sistem informasi yang lebih baik. Merancang sistem informasi yangberbasis komputer untuk membantu mengatasi kelemahan dalam pengolahan datamenjadi informasi sesuai dengan kebutuhan user. Hasil analisis menunjukkan bahwapengolahan data di Rita Pasaraya Kebondalem Purwokerto mosih menggunakansistem manual. Sistem yang baru yaitu komputerisasi akan lebih tepat biladipergunakan untuk kehandalan data gaji karyawan. Selain sistem yang baru secarakomputerisasi kedisiplinan pemakai juga perlu ditingkatkan, secara fasilitastambahan selain ruangan khusus yaitu adanya Air Condisioner (AC pada ruangkomputer untuk membuat awet secara perangkat keras komputer dan komputer dapatdihidupkan secara terus menerus. Sistem yang baru aknn menambah kepercayaanImryawan dan pihak lain yang membutuhkan karena akurat, tepat dan handal. Sertapengambilan keputusan tentang kondisi data gaji karyawan dapat lebih alatrat dancepat yang tidak lain dapat meningkatkan kinerja karyawan terhadap perusahaan.

  7. Te Rita Papesch: Case Study of an Exemplary Learner of Maori as an Additional Language

    Science.gov (United States)

    Ratima, Matiu Tai; Papesch, Te Rita

    2014-01-01

    This paper presents a case study of the life experiences of one exemplar adult second language Maori learner--Te Rita Papesch. Te Rita was one of 17 participants who were interviewed as a part of the first author's PhD study which sought to answer the question: what factors lead to the development of proficiency in te reo Maori amongst adult…

  8. O Centro Espírita Redemptor e o tratamento de doença mental, 1910-1921 The Centro Espírita Redemptor and the treatment of mental illness, 1910-1921

    Directory of Open Access Journals (Sweden)

    André de Faria Pereira Neto

    2012-06-01

    Full Text Available O espiritismo é uma doutrina religiosa que surgiu na França durante o século XIX por meio da obra de Allan Kardec. No Brasil, assumiu certa originalidade: o espiritismo racional e científico cristão, liderado por Luiz de Mattos, foi uma de suas vertentes doutrinárias nacionais. Luiz de Mattos criou o Centro Espírita Redemptor onde, durante alguns anos, acompanhou o tratamento dos doentes mentais. O artigo analisa as características do tratamento espírita racional e científico cristão à doença mental e as estratégias que Luiz de Mattos adotou para defender sua forma de tratamento. Apresenta ainda algumas semelhanças e diferenças entre o tratamento espírita e o médico.Spiritism is a religious doctrine originated in France during the nineteenth century through the works of Allan Kardec. In Brazil, it assumed an original configuration: rational and scientific Christian spiritism, pioneered by Luiz de Mattos, was one of the national doctrinal variants. Luiz de Mattos created the Centro Espírita Redemptor where, for some years, he monitored the treatment of the mentally ill. The article analyzes the characteristics of rational and scientific Christian spiritism treatment applied to mental illness and the strategies that Luiz de Mattos adopted to defend his form of treatment. Some similarities and differences between spiritist and medical treatment are also outlined.

  9. Shelf sediment transport during hurricanes Katrina and Rita

    Science.gov (United States)

    Xu, Kehui; Mickey, Rangley C.; Chen, Qin; Harris, Courtney K.; Hetland, Robert D.; Hu, Kelin; Wang, Jiaze

    2016-05-01

    Hurricanes can greatly modify the sedimentary record, but our coastal scientific community has rather limited capability to predict hurricane-induced sediment deposition. A three-dimensional sediment transport model was developed in the Regional Ocean Modeling System (ROMS) to study seabed erosion and deposition on the Louisiana shelf in response to Hurricanes Katrina and Rita in the year 2005. Sensitivity tests were performed on both erosional and depositional processes for a wide range of erosional rates and settling velocities, and uncertainty analysis was done on critical shear stresses using the polynomial chaos approximation method. A total of 22 model runs were performed in sensitivity and uncertainty tests. Estimated maximum erosional depths were sensitive to the inputs, but horizontal erosional patterns seemed to be controlled mainly by hurricane tracks, wave-current combined shear stresses, seabed grain sizes, and shelf bathymetry. During the passage of two hurricanes, local resuspension and deposition dominated the sediment transport mechanisms. Hurricane Katrina followed a shelf-perpendicular track before making landfall and its energy dissipated rapidly within about 48 h along the eastern Louisiana coast. In contrast, Hurricane Rita followed a more shelf-oblique track and disturbed the seabed extensively during its 84-h passage from the Alabama-Mississippi border to the Louisiana-Texas border. Conditions to either side of Hurricane Rita's storm track differed substantially, with the region to the east having stronger winds, taller waves and thus deeper erosions. This study indicated that major hurricanes can disturb the shelf at centimeter to meter levels. Each of these two hurricanes suspended seabed sediment mass that far exceeded the annual sediment inputs from the Mississippi and Atchafalaya Rivers, but the net transport from shelves to estuaries is yet to be determined. Future studies should focus on the modeling of sediment exchange between

  10. Relativistic finite-temperature Thomas-Fermi model

    Science.gov (United States)

    Faussurier, Gérald

    2017-11-01

    We investigate the relativistic finite-temperature Thomas-Fermi model, which has been proposed recently in an astrophysical context. Assuming a constant distribution of protons inside the nucleus of finite size avoids severe divergence of the electron density with respect to a point-like nucleus. A formula for the nuclear radius is chosen to treat any element. The relativistic finite-temperature Thomas-Fermi model matches the two asymptotic regimes, i.e., the non-relativistic and the ultra-relativistic finite-temperature Thomas-Fermi models. The equation of state is considered in detail. For each version of the finite-temperature Thomas-Fermi model, the pressure, the kinetic energy, and the entropy are calculated. The internal energy and free energy are also considered. The thermodynamic consistency of the three models is considered by working from the free energy. The virial question is also studied in the three cases as well as the relationship with the density functional theory. The relativistic finite-temperature Thomas-Fermi model is far more involved than the non-relativistic and ultra-relativistic finite-temperature Thomas-Fermi models that are very close to each other from a mathematical point of view.

  11. Santa Rita Experimental Range digital database: user's guide

    Science.gov (United States)

    Mitchel P. McClaran; Deborah L. Angell; Craig Wissler

    2002-01-01

    Long-term measurements and repeat photograph collections have been collected in a systematic manner on the approximately 21,000 ha Santa Rita Experimental Range (SRER) since its establishment in 1903. This research facility, located in the Desert Grassland vegetation of southern Arizona, was administered by the U.S. Department of Agriculture until 1988, when it was...

  12. 78 FR 22778 - Safety Zone; Corp. Event Finale UHC, St. Thomas Harbor; St. Thomas, U.S.V.I.

    Science.gov (United States)

    2013-04-17

    ... waters of St. Thomas Harbor in St. Thomas, U.S. Virgin Islands during the Corp. Event Finale UHC, a.... and 5 p.m., Monday through Friday, except Federal holidays. FOR FURTHER INFORMATION CONTACT: If you..., St. Thomas, U. S. Virgin Islands. The fireworks will be launched from a barge stationed near the St...

  13. Resilience of Professional Counselors Following Hurricanes Katrina and Rita

    Science.gov (United States)

    Lambert, Simone F.; Lawson, Gerard

    2013-01-01

    Professional counselors who provided services to those affected by Hurricanes Katrina and Rita completed the K6+ (screen for severe mental illness), the Posttraumatic Growth Inventory, and the Professional Quality of Life Scale. Results indicated that participants who survived the hurricanes had higher levels of posttraumatic growth than…

  14. RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.

    Science.gov (United States)

    Saha, Manujendra N; Jiang, Hua; Mukai, Asuka; Chang, Hong

    2010-11-01

    Mutations or deletions of p53 are relatively rare in multiple myeloma (MM), at least in newly diagnosed patients. Thus, restoration of p53 tumor suppressor function in MM by blocking the inhibitory role of murine double minute 2 (MDM2) is a promising and applicable therapeutic strategy. RITA and nutlin are two new classes of small molecule MDM2 inhibitors that prevent the p53-MDM2 interaction. Earlier reports showed p53-dependent activity of RITA in solid tumors as well as in leukemias. We and others recently described nutlin-induced apoptosis in MM cells, but it remains unclear whether RITA exerts antimyeloma activity. Here, we found that RITA activates the p53 pathway and induces apoptosis in MM cell lines and primary MM samples, preferentially killing myeloma cells. The activation of p53 induced by RITA was mediated through modulation of multiple apoptotic regulatory proteins, including upregulation of a proapoptotic protein (NOXA), downregulation of an antiapoptotic protein, Mcl-1, and activation of caspases through extrinsic pathways. Moreover, a number of key p53-mediated apoptotic target genes were identified by gene expression profiling and further validated by quantitative real-time PCR. Importantly, the combination of RITA with nutlin displayed a strong synergism on growth inhibition with the combination index ranging from 0.56 to 0.82 in MM cells. Our data support further clinical evaluation of RITA as a potential novel therapeutic intervention in MM. ©2010 AACR.

  15. Recognizing history in range ecology: 100 years of science and management on the Santa Rita Experimental Range

    Science.gov (United States)

    Nathan F. Sayre

    2003-01-01

    At the centennial of the Santa Rita Experimental Range, historical analysis is called for on two levels. First, as a major site in the history of range ecology, the Santa Rita illuminates past successes and failures in science and management and the ways in which larger social, economic, and political factors have shaped scientific research. Second, with the turn away...

  16. Rita Lobato: a primeira médica formada no Brasil

    Directory of Open Access Journals (Sweden)

    Francisco Bruno Lobo

    2017-04-01

    Dentre elas foi escolhida a primeira mulher que se diplomou em medicina em uma Faculdade brasileira: A Dra. Rita Lobato de Freitas . No dia 9 de junho, aniversário de seu nascimento, o referido sêlo entrou em circulação.

  17. Metal concentrations in schoolyard soils from New Orleans, Louisiana before and after Hurricanes Katrina and Rita.

    Science.gov (United States)

    Presley, Steven M; Abel, Michael T; Austin, Galen P; Rainwater, Thomas R; Brown, Ray W; McDaniel, Les N; Marsland, Eric J; Fornerette, Ashley M; Dillard, Melvin L; Rigdon, Richard W; Kendall, Ronald J; Cobb, George P

    2010-06-01

    The long-term environmental impact and potential human health hazards resulting from Hurricanes Katrina and Rita throughout much of the United States Gulf Coast, particularly in the New Orleans, Louisiana, USA area are still being assessed and realized after more than four years. Numerous government agencies and private entities have collected environmental samples from throughout New Orleans and found concentrations of contaminants exceeding human health screening values as established by the United States Environmental Protection Agency (USEPA) for air, soil, and water. To further assess risks of exposure to toxic concentrations of soil contaminants for citizens, particularly children, returning to live in New Orleans following the storms, soils collected from schoolyards prior to Hurricane Katrina and after Hurricane Rita were screened for 26 metals. Concentrations exceeding USEPA Regional Screening Levels (USEPA-RSL), total exposure, non-cancer endpoints, for residential soils for arsenic (As), iron (Fe), lead (Pb), and thallium (Tl) were detected in soil samples collected from schoolyards both prior to Hurricane Katrina and after Hurricane Rita. Approximately 43% (9/21) of schoolyard soils collected prior to Hurricane Katrina contained Pb concentrations greater than 400mgkg(-1), and samples from four schoolyards collected after Hurricane Rita contained detectable Pb concentrations, with two exceeding 1700mgkg(-1). Thallium concentrations exceeded USEPA-RSL in samples collected from five schoolyards after Hurricane Rita. Based upon these findings and the known increased susceptibility of children to the effects of Pb exposure, a more extensive assessment of the soils in schoolyards, public parks and other residential areas of New Orleans for metal contaminants is warranted. 2010 Elsevier Ltd. All rights reserved.

  18. RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.

    Science.gov (United States)

    Zhu, Hong; Abulimiti, Muyasha; Liu, Huan; Su, Xiang-Jiang; Liu, Cai-Hong; Pei, Hai-Ping

    2015-09-01

    Radiation therapy is the most widely used treatment for patients with cervical cancer. Recent studies have shown that endoplasmic reticulum (ER) stress induces apoptosis and sensitizes tumor cells to radiotherapy, which reportedly induces ER stress in cells. Classical key tumor suppressor p53 is involved in the response to a variety of cellular stresses, including those incurred by ionizing irradiation. A recent study demonstrated that small-molecule RITA (reactivation of p53 and induction of tumor cell apoptosis) increased the radiosensitivity of tumor cells expressing mutant p53 (mtp53). In the present study, we explored the effects and the underlying mechanisms of RITA in regards to the radiosensitivity and ER stress in mtp53-expressing human cervix cancer cells. Treatment with 1 µM of RITA for 24 h before irradiation markedly decreased survival and increased apoptosis in C-33A and HT-3 cells; the effects were not significantly altered by knockdown of p53. In the irradiated C-33A and HT-3 cells, RITA significantly increased the expression of IRE1α, the spliced XBP1 mRNA level, as well as apoptosis; the effects were abolished by knockdown of IRE1α. Transcriptional pulse-chase assays revealed that RITA significantly increased the stability of IRE1α mRNA in the irradiated C-33A and HT-3 cells. In contrast, the same RITA treatment did not show any significant effect on sham-irradiated cells. In conclusion, the present study provides initial evidence that RITA upregulates the expression level of IRE1α by increasing the stability of IRE1α mRNA in irradiated mtp53-expressing cervical cancer cells; the effect leads to enhanced IRE1α/XBP1 ER stress signaling and increased apoptosis in the cells. The present study offers novel insight into the pharmacological potential of RITA in the radiotherapy for cervical cancer.

  19. Relativistic effects in the Thomas--Fermi atom

    International Nuclear Information System (INIS)

    Waber, J.T.; Canfield, J.M.

    1975-01-01

    Two methods of applying relativistic corrections to the Thomas--Fermi atom are considered, and numerical calculations are discussed. Radial charge distributions calculated from a relativistic Thomas--Fermi equation agree in gross form with those from more complicated self-consistent calculations. Energy eigenvalues for mercury, as determined from the relativistic Thomas--Fermi solution, are compared with other calculated and experimental values

  20. A randomized comparison of the Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial: One-year angiographic results and mid-term clinical outcomes.

    Science.gov (United States)

    Kim, Ki-Bong; Hwang, Ho Young; Hahn, Seokyung; Kim, Jun Sung; Oh, Se Jin

    2014-09-01

    The Saphenous Vein Versus Right Internal Thoracic Artery as a Y-Composite Graft (SAVE RITA) trial was designed to evaluate the noninferiority of the saphenous vein (SV) compared with the right internal thoracic artery ([R]ITA) used as a Y-composite graft. A total of 224 patients who had undergone off-pump revascularization for multivessel coronary artery disease using the SV or RITA as a Y-composite graft based on the in situ left ITA were assigned randomly to the SV Y-composite graft (SV group, n = 112) or free RITA Y-composite graft (RITA group, n = 112). The primary endpoint was the 1-year angiographic patency rate of the second limb conduits (SV or RITA). Postoperative 1-year coronary angiograms were performed in 215 patients (SV group, 108; RITA group, 107). The overall graft patency rate was 97.4% (745 of 765) at 1 year (97.9% in the SV group vs 96.9% in the RITA group, P = .362). The primary endpoint of the study, the 1-year patency rate of the SV composite grafts, was 97.1% (238 of 245) and was noninferior to that of the RITA composite grafts (97.1% [198 of 204]) with a 95% lower confidence limit of -2.6% (P RITA composite grafts in terms of the 1-year angiographic patency rates. Copyright © 2014 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

  1. Thomas Jefferson's Academical Village

    DEFF Research Database (Denmark)

    Foote, Jonathan; Frohburg, Jan

    2017-01-01

    This is an essay written for the Festschrift of Karl-Heinz Schmitz, Professor at Bauhaus-Universität Weimar. It reflects on some aspects of Thomas Jefferson's design for the University of Virginia in relation to Professor's Schmitz' teachings and interests.......This is an essay written for the Festschrift of Karl-Heinz Schmitz, Professor at Bauhaus-Universität Weimar. It reflects on some aspects of Thomas Jefferson's design for the University of Virginia in relation to Professor's Schmitz' teachings and interests....

  2. Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway.

    Science.gov (United States)

    Lin, Jinshun; Jin, Xiuli; Bu, Yiwen; Cao, Deliang; Zhang, Nannan; Li, Shangfu; Sun, Qinsheng; Tan, Chunyan; Gao, Chunmei; Jiang, Yuyang

    2012-12-28

    A novel approach to synthesize RITA by practical palladium-catalyzed C-C bond-forming Suzuki reactions at room temperature was developed, which was used for deriving a series of substituted tricyclic α-heteroaryl (furan/thiophene) analogues of RITA under mild conditions. These novel analogues showed notable antiproliferative activity against cancer cell lines with wild-type p53 (i.e., HCT116, A549, MCF-7 and K562), but much less activity in HCT116/p53(-/-) cells. In particular, compound 1f demonstrated promising antiproliferative activity compared to RITA, with IC(50) = 28 nM in MCF-7 vs. 54 nM for RITA, and cancer cell selectivity. Compound 1f markedly activated p53 in HCT116 cells at 100 nM, triggering apoptosis. Importantly, we found that both RITA and compound 1f induced G(0)/G(1) cell cycle arrest by up-regulating miR-34a, which in turn down-regulated the expression of cell cycle-related proteins CDK4 and E2F1. In summary, this study reports an effective synthetic approach for RITA and its analogues, and elucidates a novel antiproliferative mechanism of these compounds.

  3. Thomas-Fermi molecular dynamics

    International Nuclear Information System (INIS)

    Clerouin, J.; Pollock, E.L.; Zerah, G.

    1992-01-01

    A three-dimensional density-functional molecular-dynamics code is developed for the Thomas-Fermi density functional as a prototype for density functionals using only the density. Following Car and Parrinello [Phys. Rev. Lett. 55, 2471 (1985)], the electronic density is treated as a dynamical variable. The electronic densities are verified against a multi-ion Thomas-Fermi algorithm due to Parker [Phys. Rev. A 38, 2205 (1988)]. As an initial application, the effect of electronic polarization in enhancing ionic diffusion in strongly coupled plasmas is demonstrated

  4. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.

    Science.gov (United States)

    Zhao, Carolyn Ying; Szekely, Laszlo; Bao, Wenjie; Selivanova, Galina

    2010-04-15

    Proteasomal degradation of p53 by human papilloma virus (HPV) E6 oncoprotein plays a pivotal role in the survival of cervical carcinoma cells. Abrogation of HPV-E6-dependent p53 destruction can therefore be a good strategy to combat cervical carcinomas. Here, we show that a small-molecule reactivation of p53 and induction of tumor cell apoptosis (RITA) is able to induce the accumulation of p53 and rescue its tumor suppressor function in cells containing high-risk HPV16 and HPV18 by inhibiting HPV-E6-mediated proteasomal degradation. RITA blocks p53 ubiquitination by preventing p53 interaction with E6-associated protein, required for HPV-E6-mediated degradation. RITA activates the transcription of proapoptotic p53 targets Noxa, PUMA, and BAX, and repressed the expression of pro-proliferative factors CyclinB1, CDC2, and CDC25C, resulting in p53-dependent apoptosis and cell cycle arrest. Importantly, RITA showed substantial suppression of cervical carcinoma xenografts in vivo. These results provide a proof of principle for the treatment of cervical cancer in a p53-dependent manner by using small molecules that target p53. (c)2010 AACR.

  5. Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer

    Directory of Open Access Journals (Sweden)

    Espinoza-Fonseca L Michel

    2005-09-01

    Full Text Available Abstract Background The use of low-molecular-weight, non-peptidic molecules that disrupt the interaction between the p53 tumor suppressor and its negative regulator MDM2 has provided a promising alternative for the treatment of different types of cancer. Among these compounds, RITA (reactivation of p53 and induction of tumor cell apoptosis has been shown to be effective in the selective induction of apoptosis, and this effect is due to its binding to the p53 tumor suppressor. Since biological systems are highly dynamic and MDM2 may bind to different regions of p53, new alternatives should be explored. On this basis, the computational "blind docking" approach was employed in this study to see whether RITA would bind to MDM2. Results It was observed that RITA binds to the MDM2 p53 transactivation domain-binding cleft. Thus, RITA can be used as a lead compound for designing improved "multi-target" drugs. This novel strategy could provide enormous benefits to enable effective anti-cancer strategies. Conclusion This study has demonstrated that a single molecule can target at least two different proteins related to the same disease.

  6. p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

    Science.gov (United States)

    Hedström, Elisabeth; Eriksson, Sofi; Zawacka-Pankau, Joanna; Arnér, Elias S J; Selivanova, Galina

    2009-11-01

    Thioredoxin reductase 1 (TrxR1) is a key regulator in many redox-dependent cellular pathways, and is often overexpressed in cancer. Several studies have identified TrxR1 as a potentially important target for anticancer therapy. The low molecular weight compound RITA (NSC 652287) binds p53 and induces p53-dependent apoptosis. Here we found that RITA also targets TrxR1 by non-covalent binding, followed by inhibition of its activity in vitro and by inhibition of TrxR activity in cancer cells. Interestingly, a novel approximately 130 kDa form of TrxR1, presumably representing a stable covalently linked dimer, and an increased generation of reactive oxygen species (ROS) were induced by RITA in cancer cells in a p53-dependent manner. Similarly, the gold-based TrxR inhibitor auranofin induced apoptosis related to oxidative stress, but independently of p53 and without apparent induction of the approximately 130 kDa form of TrxR1. In contrast to the effects observed in cancer cells, RITA did not inhibit TrxR or ROS formation in normal fibroblasts (NHDF). The inhibition of TrxR1 can sensitize tumor cells to agents that induce oxidative stress and may directly trigger cell death. Thus, our results suggest that a unique p53-dependent effect of RITA on TrxR1 in cancer cells might synergize with p53-dependent induction of pro-apoptotic genes and oxidative stress, thereby leading to a robust induction of cancer cell death, without affecting non-transformed cells.

  7. Lightcurves for Shape Modeling: 852 Wladilena, 1089 Tama, and 1180 Rita

    Science.gov (United States)

    Polishook, David

    2012-10-01

    The folded lightcurves and synodic periods of 852 Wladilena, 1089 Tama, and 1180 Rita are reported. The data are used by Hanus et al. (2012) to derive the rotation axis and to construct a shape model by applying the inversion lightcurve technique.

  8. In Conversation with: Professor Liz Thomas

    Directory of Open Access Journals (Sweden)

    Karen Nelson

    2012-08-01

    Full Text Available Editors Karen Nelson, John Clarke and Sally Kift interview Professor Liz Thomas,  Director of the Widening Participation Research Centre at Edge Hill University.  She is also Lead Adviser Retention and Success at the Higher Education Academy, England.   Professor Thomas was one of the keynote speakers at the 15th International First Year in Higher Education Conference held in Brisbane, Australia from the 26th – 29th of June, 2012.  Professor Thomas joined the Journal Editors at the conclusion of the main conference program to explore some of the key themes raised in her address.  

  9. Thomas Aquinas

    DEFF Research Database (Denmark)

    Haaning, Aksel

    2011-01-01

    Artiklen præsenterer Thomas Aquinas i højmiddelalderens intellektuelle historie, reviderer den for tiden gældende historiegrafi og præsenterer Aquinas' erotiske mystik fra prologen til Sentenskommentaren (ca.1252) og diskuterer "Aurora consurgens" som et muligt sidste skrift af den berømte...

  10. A Green Prison: The Santa Rita Jail Campus Microgrid

    Energy Technology Data Exchange (ETDEWEB)

    Marnay, Chris; DeForest, Nicholas; Lai, Judy

    2012-01-22

    A large microgrid project is nearing completion at Alameda County’s twenty-two-year-old 45 ha 4,000-inmate Santa Rita Jail, about 70 km east of San Francisco. Often described as a green prison, it has a considerable installed base of distributed energy resources (DER) including an eight-year old 1.2 MW PV array, a five-year old 1 MW fuel cell with heat recovery, and considerable efficiency investments. A current US$14 M expansion adds a 2 MW-4 MWh Li-ion battery, a static disconnect switch, and various controls upgrades. During grid blackouts, or when conditions favor it, the Jail can now disconnect from the grid and operate as an island, using the on-site resources described together with its back-up diesel generators. In other words, the Santa Rita Jail is a true microgrid, or μgrid, because it fills both requirements, i.e. it is a locally controlled system, and it can operate both grid connected and islanded. The battery’s electronics includes Consortium for Electric Reliability Technology (CERTS) Microgrid technology. This enables the battery to maintain energy balance using droops without need for a fast control system.

  11. Swamp tours in Louisiana post Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Dawn J. Schaffer; Craig A. Miller

    2007-01-01

    Hurricanes Katrina and Rita made landfall in southern Louisiana during August and September 2005. Prior to these storms, swamp tours were a growing sector of nature-based tourism that entertained visitors while teaching about local flora, fauna, and culture. This study determined post-hurricane operating status of tours, damage sustained, and repairs made. Differences...

  12. Khater method for nonlinear Sharma Tasso-Olever (STO) equation of fractional order

    Science.gov (United States)

    Bibi, Sadaf; Mohyud-Din, Syed Tauseef; Khan, Umar; Ahmed, Naveed

    In this work, we have implemented a direct method, known as Khater method to establish exact solutions of nonlinear partial differential equations of fractional order. Number of solutions provided by this method is greater than other traditional methods. Exact solutions of nonlinear fractional order Sharma Tasso-Olever (STO) equation are expressed in terms of kink, travelling wave, periodic and solitary wave solutions. Modified Riemann-Liouville derivative and Fractional complex transform have been used for compatibility with fractional order sense. Solutions have been graphically simulated for understanding the physical aspects and importance of the method. A comparative discussion between our established results and the results obtained by existing ones is also presented. Our results clearly reveal that the proposed method is an effective, powerful and straightforward technique to work out new solutions of various types of differential equations of non-integer order in the fields of applied sciences and engineering.

  13. RITA: The reinvented triple axis spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Mason, T.E. [Toronto Univ., ON (Canada). Dept. of Physics; Clausen, K.N.; Aeppli, G.; McMorrow, D.R.; Kjems, J.K. [Risoe National Lab., Roskilde (Denmark)

    1995-11-01

    Risoe National Laboratory was reported to be in the process of developing a new spectrometer design, RITA, based on the triple axis design. The spectrometer will attempt to incorporate more recent innovations such as multilayer supermirrors and microstrip proportional counters into a rethinking of the triple-axis spectrometer. By optimizing the beam optics, using supermirrors and extending the analyser to map regions of (Q, {omega}) space using an array of independently controllable pyrolytic graphite crystals focussed on an area detector, it was hoped that the efficiency of single-crystal inelastic experiments could be increased by as much as a factor of 20. 7 figs., 20 refs.

  14. Effects of hurricanes Katrina and Rita on the chemistry of bottom sediments in Lake Pontchartrain, Louisiana, USA

    Science.gov (United States)

    Van Metre, P.C.; Horowitz, A.J.; Mahler, B.J.; Foreman, W.T.; Fuller, C.C.; Burkhardt, M.R.; Elrick, K.A.; Furlong, E.T.; Skrobialowski, S.C.; Smith, J.J.; Wilson, J.T.; Zaugg, S.D.

    2006-01-01

    The effects of Hurricanes Katrina and Rita and the subsequent unwatering of New Orleans, Louisiana, on the sediment chemistry of Lake Pontchartrain were evaluated by chemical analysis of samples of street mud and suspended and bottom sediments. The highest concentrations of urban-related elements and compounds (e.g., Pb, Zn, polycyclic aromatic hydrocarbons, and chlordane) in bottom sediments exceeded median concentrations in U.S. urban lakes and sediment-quality guidelines. The extent of the elevated concentrations was limited, however, to within a few hundred meters of the mouth of the 17th Street Canal, similar to results of historical assessments. Chemical and radionuclide analysis of pre- and post-Hurricane Rita samples indicates that remobilization of near-shore sediment by lake currents and storms is an ongoing process. The effects of Hurricanes Katrina and Rita on the sediment chemistry of Lake Pontchartrain are limited spatially and are most likely transitory. ?? 2006 American Chemical Society.

  15. Geology of Santa Rita Coal Basin, Rio Grande do Sul, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Correa da Silva, Z.C.; Bortoluzzi, C.A.; Cazzulo-Klepzig, M.; Dias-Fabricio, M.E.; Guerra-Sommer, M.; Marques-Toigo, M.; Paim, P.S.G.; Piccoli, A.E.M.; Silva Filho, B.C.

    1984-04-01

    Data on the sedimentology, stratigraphy, palynology, coal petrography and geochemistry of the Santa Rita Coal Basin, Rio Grande do Sul, Brazil, are presented. The investigations were carried out on samples obtained from drill cores of the sedimentary rocks of Tubarao Supergroup, Lower Permian of Parana Basin. (25 refs.)

  16. Plekktrummeldajate lastel on Stasi legendid / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2000-01-01

    50. Berliini filmifestivalil linastunud saksa režissööri Volker Schlöndorffi mängufilmist "Rita legendid" ja Tom Cruiseþi osatäitmisest Paul Thomas Andersoni filmis "Magnolia" : Ameerika Ühendriigid

  17. Sir John and Lady Rita Cornforth: a distinguished chemical partnership.

    Science.gov (United States)

    Purchase, Rupert; Hanson, James R

    2015-01-01

    This review describes the life of Sir John Cornforth AC CBE FRS, who was awarded the Nobel Prize for Chemistry in 1975. It covers his early life in Australia, his work in Oxford, the National Institute for Medical Research, the Milstead Laboratory of Chemical Enzymology and the University of Sussex, together with the contributions made by his wife, Lady Rita Cornforth.

  18. Integration& Operation of a Microgrid at Santa Rita Jail

    Energy Technology Data Exchange (ETDEWEB)

    Chevron Energy Solutions; Alameda County; DeForest, Nicholas; Lai, Judy; Stadler, Michael; Mendes, Goncalo; Marnay, Chris; Donadee, Jon

    2011-05-01

    Santa Rita Jail is a 4,500 inmate facility located in Dublin CA, approximately 40 miles (65 km) east of San Francisco. Over the past decade, a series of Distributed Energy Resources (DER) installations and efficiency measures have been undertaken to transform the 3MW facility into a"Green Jail". These include a 1.2MW rated rooftop PV system installed in 2002, a 1MW molten carbonate fuel cell with CHP, and retrofits to lighting and HVAC systems to reduce peak loads. With the upcoming installation of a large-scale battery and fast static disconnect switch, Santa Rita Jail will become a true microgrid, with full CERTS Microgrid functionality. Consequently, the jail will be able to seamlessly disconnect from the grid and operate as an island in the event of a disturbance, reconnecting again once the disturbance has dissipated. The extent to which that jail is capable of islanding is principally dependant on the energy capacity of the battery-one focus of this investigation. Also presented here are overviews of the DER currently installed at the jail, as well as the value it provides by offsetting the purchase of electricity under the current Pacific Gas& Electric (PG&E) tariff.

  19. Pipe failure probability - the Thomas paper revisited

    International Nuclear Information System (INIS)

    Lydell, B.O.Y.

    2000-01-01

    Almost twenty years ago, in Volume 2 of Reliability Engineering (the predecessor of Reliability Engineering and System Safety), a paper by H. M. Thomas of Rolls Royce and Associates Ltd. presented a generalized approach to the estimation of piping and vessel failure probability. The 'Thomas-approach' used insights from actual failure statistics to calculate the probability of leakage and conditional probability of rupture given leakage. It was intended for practitioners without access to data on the service experience with piping and piping system components. This article revisits the Thomas paper by drawing on insights from development of a new database on piping failures in commercial nuclear power plants worldwide (SKI-PIPE). Partially sponsored by the Swedish Nuclear Power Inspectorate (SKI), the R and D leading up to this note was performed during 1994-1999. Motivated by data requirements of reliability analysis and probabilistic safety assessment (PSA), the new database supports statistical analysis of piping failure data. Against the background of this database development program, the article reviews the applicability of the 'Thomas approach' in applied risk and reliability analysis. It addresses the question whether a new and expanded database on the service experience with piping systems would alter the original piping reliability correlation as suggested by H. M. Thomas

  20. The RITA spectrometer at Risø - design considerations and recent results

    Science.gov (United States)

    Clausen, K. N.; McMorrow, D. F.; Lefmann, K.; Aeppli, G.; Mason, T. E.; Schröder, A.; Issikii, M.; Nohara, M.; Takagi, H.

    In the new cold triple axis spectrometer RITA at Risø we have improved the front end by extensive use of state of the art optical elements and better shielding material. The analyser system is situated in one large open tank and consists of seven individually orientable PG(002) crystal analyser blades, and a 170 mm by 120 mm 2 areas sensitive micro-strip detector. In comparison to the old TAS6 spectrometer we have obtained a factor 2-5 gain in intensity on the sample, a substantially lower background, much more flexibility for optimising the instrument and the possibility to go beyond simple point-by-point inspection. The excellent performance of RITA in the standard TAS mode is exemplified by a study of the dynamics of ≈ 15 nm hematite (α-Fe 2O 3) nano-particles, and utilisation of horizontal and vertical focusing modes to study two dimensional systems is illustrated by a study of the spin fluctuations in the high Tc superconductor La 1.83Sr 0.17CuO 4.

  1. Secondary eyewall formation in WRF simulations of Hurricanes Rita and Katrina (2005)

    Science.gov (United States)

    Abarca, Sergio F.; Corbosiero, Kristen L.

    2011-04-01

    An analysis is presented of two high-resolution hurricane simulations of Katrina and Rita (2005) that exhibited secondary eyewall formation (SEF). The results support the notion of vortex Rossby waves (VRWs) having an important role in SEF and suggest that VRW activity is a defining aspect of the moat. SEF occurs at a radius of ˜65 (80) km in Katrina (Rita), close to the hypothesized stagnation radius of VRWs. VRW activity appears to be the result of eye-eyewall mixing events, themselves a product of the release of barotropic instability. The convection in the radial region that becomes the moat is mainly in the form of VRWs propagating radially outward from the primary eyewall until the negative radial gradient of potential vorticity is no longer conducive for their propagation. These convectively coupled waves, originating and being expelled from the eyewall, are rotation dominated and have the coherency necessary to survive their passage through the strain-dominated region outside the eyewall.

  2. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu).

    Science.gov (United States)

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

    2016-06-01

    Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray.

  3. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

    International Nuclear Information System (INIS)

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu; You, Qingshan

    2016-01-01

    Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray

  4. The Impact of Hurricanes Katrina and Rita on Louisiana School Nurses

    Science.gov (United States)

    Broussard, Lisa; Myers, Rachel; Meaux, Julie

    2008-01-01

    In the fall of 2005, the coast of Louisiana was devastated by two hurricanes, Katrina and Rita. Not only did these natural disasters have detrimental effects for those directly in their path, the storms had an impact on the lives of everyone in Louisiana. The professional practice of many Louisiana school nurses was affected by several factors,…

  5. The provenance and Sm/Nd Model ages of siliciclastic supracrustal rocks of the Faina and Santa Rita Greenstone belts, Goias, Brazil; Proveniencia e idades modelo Sm/Nd das rochas siliciclasticas arqueanas dos greenstone belts de Faina e Santa Rita, Goias

    Energy Technology Data Exchange (ETDEWEB)

    Resende, Marcelo Goncalves [Universidade Catolica de Brasilia, DF (Brazil); Jost, Hardy [Brasilia Univ., DF (Brazil). Inst. de Geociencias; Lima, Bruno Eustaquio Moreira; Teixeira, Alexandre de Amorim

    1999-09-01

    The Faina and Santa Rita greenstone belts are two N 60 deg C W trending synclinoria separated by a N 30 deg C E strike-slip fault and rest allochtonous on the adjacent Uva and Caicara granite-gneiss complexes. The belts are made up of lower metakomatiites, followed by metabasalts and thick metasedimentary sequences deposited under contrasting paleogeographic settings. In Faina, the sequence consists of two complete shelf cycles, the first resting on basalts by an erosional unconformity. In Santa Rita, the basalts give gradually place to carbonaceous metashales, unconformably overlain by metarhythmites. Provenance based on trace element geochemistry, mineral chemistry of chloride and muscovite, source-are modeling and REE elements indicate that protoliths of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita formed under the influence of a source area dominated by mafic ultramafic rocks, whilst during the sedimentation of the second shelf cycle and the metarhythmites of Santa Rita the source-area was dominated by TTG granitoids. Sm-Nd model ages of the lower sedimentary packages vary between 3.0 and 2.8 Ga and the upper between 2.7 and 2.6 Ga. These intervals coincide, respectively, with the estimated age of the underlying, and with the Sm-Nd, Rb-Sr e U-Pb ages of the main granitoids and gneisses of the adjacent complexes. The same data indicate that, during the sedimentation of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita, both basins had independent source-areas, but shared the same source during the upper sections. Weathering nature and intensity of the source-area calculated by means of geochemical a data suggest that the dramatic change of provenance from the lower to the upper sections is due to the shift from tectonically stable to unstable regimes, interpreted as resulting from the emergence of the island arc whose roots are represented by the adjacent granite-gneiss complexes. (author)

  6. Damage to offshore infrastructure in the Gulf of Mexico by hurricanes Katrina and Rita

    Science.gov (United States)

    Cruz, A. M.; Krausmann, E.

    2009-04-01

    The damage inflicted by hurricanes Katrina and Rita to the Gulf-of-Mexico's (GoM) oil and gas production, both onshore and offshore, has shown the proneness of industry to Natech accidents (natural hazard-triggered hazardous-materials releases). In order to contribute towards a better understanding of Natech events, we assessed the damage to and hazardous-materials releases from offshore oil and natural-gas platforms and pipelines induced by hurricanes Katrina and Rita. Data was obtained through a review of published literature and interviews with government officials and industry representatives from the affected region. We also reviewed over 60,000 records of reported hazardous-materials releases from the National Response Center's (NRC) database to identify and analyze the hazardous-materials releases directly attributed to offshore oil and gas platforms and pipelines affected by the two hurricanes. Our results show that hurricanes Katrina and Rita destroyed at least 113 platforms, and severely damaged at least 53 others. Sixty percent of the facilities destroyed were built 30 years ago or more prior to the adoption of the more stringent design standards that went into effect after 1977. The storms also destroyed 5 drilling rigs and severely damaged 19 mobile offshore drilling units (MODUs). Some 19 MODUs lost their moorings and became adrift during the storms which not only posed a danger to existing facilities but the dragging anchors also damaged pipelines and other infrastructure. Structural damage to platforms included toppling of sections, and tilting or leaning of platforms. Possible causes for failure of structural and non-structural components of platforms included loading caused by wave inundation of the deck. Failure of rigs attached to platforms was also observed resulting in significant damage to the platform or adjacent infrastructure, as well as damage to equipment, living quarters and helipads. The failures are attributable to tie-down components

  7. Electron-electron Thomas peak in fast transfer ionization

    International Nuclear Information System (INIS)

    Tolmanov, S. G.; McGuire, J. H.

    2000-01-01

    ''Thomas process'' is a name used for a family of singular two-step processes that can lead to electron transfer. The Thomas process of the ''second kind,'' occurring in reactions with both transfer and ionization, utilizes the e-e scattering in the second step, so this Thomas process requires the dynamics of the electron-electron interaction. We calculate numerically the second order element of an S matrix and corresponding cross sections for the transfer ionization process. We find that the position and shape of the Thomas peak depend on both electron-electron and the electron-nucleus interaction. Also the direct and exchange amplitudes are equal at the peak position. We test the peaking approximation used for transfer ionization. Our results can be compared to experimental results for p + +He→H+He 2+ +e - . (c) 2000 The American Physical Society

  8. A Kiss Lajos-díj 2016. évi nyertese: dr. Póczos Rita [Winner of the 2016 Lajos Kiss Prize: Dr Rita Póczos

    Directory of Open Access Journals (Sweden)

    Hoffmann, István

    2016-12-01

    Full Text Available The Lajos Kiss Prize, awarded every two or three years since 2006, is considered to be a highly prestigious award for young onomasticians. The 2016 winner of the prize is Dr Rita Póczos, senior lecturer at the Department of Hungarian Linguistics of the University of Debrecen. She was given this award for her contribution to Hungarian Historical Onomastics, especially for her research on place names.

  9. Thomas Fermi model of finite nuclei

    International Nuclear Information System (INIS)

    Boguta, J.; Rafelski, J.

    1977-01-01

    A relativistic Thomas-Fermi model of finite-nuclei is considered. The effective nuclear interaction is mediated by exchanges of isoscalar scalar and vector mesons. The authors include also a self-interaction of the scalar meson field and the Coulomb repulsion of the protons. The parameters of the model are constrained by the average nuclear properties. The Thomas-Fermi equations are solved numerically for finite, stable nuclei. The particular case of 208 82 Pb is considered in more detail. (Auth.)

  10. Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.

    Science.gov (United States)

    Di Marzo, Domenico; Forte, Iris Maria; Indovina, Paola; Di Gennaro, Elena; Rizzo, Valeria; Giorgi, Francesca; Mattioli, Eliseo; Iannuzzi, Carmelina Antonella; Budillon, Alfredo; Giordano, Antonio; Pentimalli, Francesca

    2014-01-01

    Malignant mesothelioma, a very aggressive tumor associated to asbestos exposure, is expected to increase in incidence, and unfortunately, no curative modality exists. Reactivation of p53 is a new attractive antitumoral strategy. p53 is rarely mutated in mesothelioma, but it is inactivated in most tumors by the lack of p14(ARF). Here, we evaluated the feasibility of this approach in pleural mesothelioma by testing RITA and nutlin-3, two molecules able to restore p53 function through a different mechanism, on a panel of mesothelioma cell lines representing the epithelioid (NCI-H28, NCI-H2452, IST-MES 2), biphasic (MSTO-211H), and sarcomatoid (NCI-H2052) histotypes compared with the normal mesothelial HMC-hTERT. RITA triggered robust caspase-dependent apoptosis specifically in epithelioid and biphasic mesothelioma cell lines, both through wild-type and mutant p53, concomitant to p21 downregulation. Conversely, nutlin-3 induced a p21-dependent growth arrest, rather than apoptosis, and was slightly toxic on HMC-hTERT.   Interestingly, we identified a previously undetected point mutation of p53 (p.Arg249Ser) in IST-MES 2, and showed that RITA is also able to reactivate this p53 mutant protein and its apoptotic function. RITA reduced tumor growth in a MSTO-211H-derived xenograft model of mesothelioma and synergized with cisplatin, which is the mainstay of treatment for this tumor. Our data indicate that reactivation of p53 and concomitant p21 downregulation effectively induce cell death in mesothelioma, a tumor characterized by a high intrinsic resistance to apoptosis. Altogether, our findings provide the preclinical framework supporting the use of p53-reactivating agents alone, or in combination regimens, to improve the outcome of patients with mesothelioma.

  11. Effects of marsh pond terracing on coastal wintering waterbirds before and after Hurricane Rita.

    Science.gov (United States)

    O'Connell, Jessica L; Nyman, John A

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  12. Effects of Marsh Pond Terracing on Coastal Wintering Waterbirds Before and After Hurricane Rita

    Science.gov (United States)

    O'Connell, Jessica L.; Nyman, John A.

    2011-11-01

    From February to March 2005-2006, we surveyed wintering waterbirds to test effects of terracing on coastal pond use before and after Hurricane Rita. Marsh terracing is intended to slow coastal marsh loss in the Chenier Plain by slowing marsh erosion and encouraging vegetation expansion. Terraces also increase marsh edge in ponds, possibly benefiting waterbirds. We monitored paired terraced and unterraced ponds in three sites within southwestern Louisiana's Chenier Plain. Waterbirds were 75% more numerous in terraced than unterraced ponds. Waterbird richness was similar among ponds when corrected for number of individuals, suggesting terracing increased bird density but did not provide habitat unique from unterraced ponds. Birds were 93% more numerous following Hurricane Rita, mostly due to an influx of migrating waterfowl. Year round residents were similar in number before and after Hurricane Rita. Resident richness did not differ among years after correcting for number of observed individuals. Wading and dabbling foragers were more abundant in terraced ponds and these two guilds represented 74% of birds observed. We detected no difference among ponds for other guilds, i.e., probing, aerial, and diving foragers. Increasing proportion of mash edge increased bird density disproportionately: On average ponds with 10% edge had 6 birds observed and ponds with 30% edge had 16 birds observed. Terraces increased habitat interspersion and were an effective tool for increasing numbers of wintering waterfowl and wading birds. The extent to which terraces were sustainable following hurricane forces is unknown.

  13. 76 FR 26223 - Petition for Rulemaking Submitted by Thomas Popik

    Science.gov (United States)

    2011-05-06

    ... Rulemaking Submitted by Thomas Popik AGENCY: Nuclear Regulatory Commission. ACTION: Petition for rulemaking... filed with the NRC by Thomas Popik. The petition was docketed by the NRC on March 15, 2011, and has been... received a petition for rulemaking on March 14, 2011 (PRM- 50-96). The petition was submitted by Mr. Thomas...

  14. J K Thomas

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. J K Thomas. Articles written in Bulletin of Materials Science. Volume 31 Issue 5 October 2008 pp 719-722 Nanomaterials. Synthesis, characterization, sintering and dielectric properties of nanostructured perovskite-type oxide, Ba2GdSbO6 · C Vijayakumar H Padma Kumar Sam ...

  15. Principal Component Surface (2011) for St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.3x0.3 meter principal component analysis (PCA) surface for areas the St. Thomas East End Reserve (STEER) in the U.S. Virgin Islands (USVI)....

  16. Thomas Bartholin. Domus Anatomica Hafniensis brevissima descripta

    DEFF Research Database (Denmark)

    Bruun, Niels W.; Fink-Jensen, Morten

    In 1662 Thomas Bartholin published A Short Description of the Anatomy House in Copenhagen, which describes the layout of the Anatomy House alongside the first eighteen years of its history.......In 1662 Thomas Bartholin published A Short Description of the Anatomy House in Copenhagen, which describes the layout of the Anatomy House alongside the first eighteen years of its history....

  17. RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.

    Science.gov (United States)

    Surget, Sylvanie; Descamps, Géraldine; Brosseau, Carole; Normant, Vincent; Maïga, Sophie; Gomez-Bougie, Patricia; Gouy-Colin, Nadège; Godon, Catherine; Béné, Marie C; Moreau, Philippe; Le Gouill, Steven; Amiot, Martine; Pellat-Deceunynck, Catherine

    2014-06-14

    The aim of this study was to evaluate the efficacy of the p53-reactivating drugs RITA and nutlin3a in killing myeloma cells. A large cohort of myeloma cell lines (n = 32) and primary cells (n = 21) was used for this study. This cohort contained cell lines with various TP53 statuses and primary cells with various incidences of deletion of chromosome 17. Apoptosis was evaluated using flow cytometry with Apo2.7 staining of the cell lines or via the loss of the myeloma-specific marker CD138 in primary cells. Apoptosis was further confirmed by the appearance of a subG1 peak and the activation of caspases 3 and 9. Activation of the p53 pathway was monitored using immunoblotting via the expression of the p53 target genes p21, Noxa, Bax and DR5. The involvement of p53 was further studied in 4 different p53-silenced cell lines. Both drugs induced the apoptosis of myeloma cells. The apoptosis that was induced by RITA was not related to the TP53 status of the cell lines or the del17p status of the primary samples (p = 0.52 and p = 0.80, respectively), and RITA did not commonly increase the expression level of p53 or p53 targets (Noxa, p21, Bax or DR5) in sensitive cells. Moreover, silencing of p53 in two TP53(mutated) cell lines failed to inhibit apoptosis that was induced by RITA, which confirmed that RITA-induced apoptosis in myeloma cells was p53 independent. In contrast, apoptosis induced by nutlin3a was directly linked to the TP53 status of the cell lines and primary samples (p RITA, in contrast to nutlin3a, effectively induced apoptosis in a subset of MM cells independently of p53. The findings and could be of interest for patients with a 17p deletion, who are resistant to current therapies.

  18. REMOTE SENSING DAMAGE ASSESSMENT OF CHEMICAL PLANTS AND REFINERIES FOLLOWING HURRICANES KATRINA AND RITA

    Science.gov (United States)

    The massive destruction brought by Hurricanes Katrina and Rita also impacted the many chemical plants and refineries in the region. The achievement of this rapid analysis capability highlights the advancement of this technology for air quality assessment and monitoring. Case st...

  19. Rita Thalmann (1926-2013), Pioneer of Women’s History

    OpenAIRE

    Hoock-Demarle, Marie-Claire

    2017-01-01

    Born in Nuremberg to a German-Jewish father and a Swiss-Jewish mother, Rita Thalmann fled the Nazi regime with her family in 1933, first taking refuge in Switzerland and then in France. After losing both her father (denounced and deported to Auschwitz), and her mother (who died of malnutrition while interned in Dijon), she survived the war through a support network organized by the headmistress of Dijon’s girls’ lycée, Marcelle Pardé, a member of the Resistance later deported to Ravensbrück. ...

  20. 75 FR 4061 - Favinger, Thomas; Notice of Filing

    Science.gov (United States)

    2010-01-26

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6223-000] Favinger, Thomas; Notice of Filing January 19, 2010. Take notice that on January 15, 2010, Mr. Thomas G. Favinger filed an application for authority to hold interlocking positions, pursuant to section 305(b) of the...

  1. Ritacestus gen. n. (Cestoda: Proteocephalidea) and redescription of R. ritaii comb. n., a parasite of Rita rita (Siluriformes) in India.

    Science.gov (United States)

    de Chambrier, Alain; Scholz, Tomás; Ash, Anirban; Kar, Pradip Kumar

    2011-11-01

    A new genus, Ritacestus, is proposed to accommodate Ritacestus ritaii (Verma, 1926) comb. n. (syn. Proteocephalus ritaii), a parasite of the catfish Rita rita (Hamilton) in India. The new genus, which is placed in the Gangesiinae, is characterized by (i) a small, subspherical scolex formed by four large lobes separated from one another by longitudinal grooves, with a large, widely oval to pyriform rostellum-like apical organ, larger than suckers and possessing an apical hemispherical depression; (ii) paramuscular and cortical position of some vitelline follicles (most follicles are situated medullary); (iii) ventral and dorsal bands of vitelline follicles usually uninterrupted ventral to terminal genitalia and reaching to the posterior margin of proglottides; (iv) the vagina always anterior to the cirrus-sac; (v) a large size of the body (length up to 51 cm); and (vi) development of the uterus of type 2. In its morphology, especially shape of the scolex and apical organ, and paramuscular and cortical position of some vitelline follicles, Ritacestus resembles Postgangesia Akhmerov, 1969, but differs in the presence of a genital atrium (both genital pores of Postgangesia are separate), the anterior position of the vagina (almost always posterior in the latter genus), position of vitelline follicles in cross sections (dorsal and ventral bands in Ritacestus versus only a lateral band in the latter genus), and dorsal excretory canals indistinguishable in mature and gravid proglottides of R. ritaii (well developed in Postgangesia spp.). The type and only species of the genus, R. ritaii, is redescribed on the basis of new material from the type host from the Ganges River basin in India and its neotype is designated.

  2. Vivien Thomas (1910-1985): the backstage pioneer and educator.

    Science.gov (United States)

    Ng, Chin Ting Justin

    2014-06-01

    Vivien Thomas (1910-1985) was an African-American scientist, pioneer, and renowned educator. Thomas's contributions to cardiovascular surgery were unequivocal, and yet it was only after his death that he gained more widespread recognition. Thomas's more notable work involves aiding in the discovery of the cause of traumatic shock, designing and guiding the first operation to treat Tetralogy of Fallot, carrying out the first atrial septectomy, and helping develop the electrical defibrillator. Thomas struggled amidst the adversities of racism and the Great Depression (1929-1941), armed merely with a high school degree. Nevertheless, his genius and determination eventually led him to receive an honorary doctorate from John Hopkins University. His story inspired the creation of the award winning PBS documentary in 2003 Partners of the Heart and also the 2004 Emmy Award-winning HBO film Something the Lord Made. This article will aim to provide an overview to the more notable events in Thomas's amazing tale, with a particular focus on his work on the Tetralogy of Fallot.

  3. Q & A with Ed Tech Leaders: Interview with Curtis J. Bonk, Mimi Miyoung Lee, Thomas C. Reeves, & Thomas H. Reynolds

    Science.gov (United States)

    Viner, Mark; Gardner, Ellen; Shaughnessy, Michael F.

    2016-01-01

    Curtis J. Bonk, is Professor of Instructional Systems Technology at Indiana University and President of CourseShare. Mimi Miyoung Lee is Associate Professor in the Department of Curriculum and instruction at the University of Houston. Thomas C. Reeves is Professor Emeritus of Learning, Design, and Technology at the University of Georgia. Thomas H.…

  4. Thomas Gordon's Communicative Pedagogy in Modern Educational Realities

    Science.gov (United States)

    Leshchenko, Maria; Isaieva, Svitlana

    2014-01-01

    In the article the principles, strategies, methods, techniques of communicative pedagogy of American scientist Thomas Gordon and system components of effective communication training for parents, teachers and administrators are enlightened. It has been determined that the main principle of Thomas Gordon's pedagogy is an interactive way of knowing…

  5. External factors impacting hospital evacuations caused by Hurricane Rita: the role of situational awareness.

    Science.gov (United States)

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    The 2005 Gulf Coast hurricane season was one of the most costly and deadly in US history. Hurricane Rita stressed hospitals and led to multiple, simultaneous evacuations. This study systematically identified community factors associated with patient movement out of seven hospitals evacuated during Hurricane Rita. This study represents the second of two systematic, observational, and retrospective investigations of seven acute care hospitals that reported off-site evacuations due to Hurricane Rita. Participants from each hospital included decision makers that comprised the Incident Management Team (IMT). Investigators applied a standardized interview process designed to assess evacuation factors related to external situational awareness of community activities during facility evacuation due to hurricanes. The measured outcomes were responses to 95 questions within six sections of the survey instrument. Investigators identified two factors that significantly impacted hospital IMT decision making: (1) incident characteristics affecting a facility's internal resources and challenges; and (2) incident characteristics affecting a facility's external evacuation activities. This article summarizes the latter and reports the following critical decision making points: (1) Emergency Operations Plans (EOP) were activated an average of 85 hours (3 days, 13 hours) prior to Hurricane Rita's landfall; (2) the decision to evacuate the hospital was made an average of 30 hours (1 day, 6 hours) from activation of the EOP; and (3) the implementation of the evacuation process took an average of 22 hours. Coordination of patient evacuations was most complicated by transportation deficits (the most significant of the 11 identified problem areas) and a lack of situational awareness of community response activities. All evacuation activities and subsequent evacuation times were negatively impacted by an overall lack of understanding on the part of hospital staff and the IMT regarding how to

  6. Reexamination of shell model tests of the Porter-Thomas distribution

    International Nuclear Information System (INIS)

    Grimes, S.M.

    1983-01-01

    Recent shell model calculations have yielded width amplitude distributions which have apparently not agreed with the Porter-Thomas distribution. This result conflicts with the present experimental evidence. A reanalysis of these calculations suggests that, although correct, they do not imply that the Porter-Thomas distribution will fail to describe the width distributions observed experimentally. The conditions for validity of the Porter-Thomas distribution are discussed

  7. Sediment deposition from Hurricane Rita on Hackberry Beach chenier in southwestern Louisiana: Chapter 6E in Science and the storms-the USGS response to the hurricanes of 2005

    Science.gov (United States)

    Faulkner, Stephen; Barrow, Wylie; Doyle, Thomas; Baldwin, Michael; Michot, Thomas; Wells, Christopher; Jeske, Clint

    2007-01-01

    Hurricane Rita significantly impacted the chenier forests of southwestern Louisiana, an important habitat for Neotropical migratory birds. Sediment deposition was measured along transects at Hackberry Beach chenier, and Rita's effects on chenier structure and morphology were determined.

  8. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro.

    Science.gov (United States)

    Burmakin, Mikhail; Shi, Yao; Hedström, Elisabeth; Kogner, Per; Selivanova, Galina

    2013-09-15

    Restoration of the p53 function in tumors is a promising therapeutic strategy due to the high potential of p53 as tumor suppressor and the fact that established tumors depend on p53 inactivation for their survival. Here, we addressed the question whether small molecule RITA can reactivate p53 in neuroblastoma and suppress the growth of neuroblastoma cells in vitro and in vivo. The ability of RITA to inhibit growth and to induce apoptosis was shown in seven neuroblastoma cell lines. Mechanistic studies were carried out to determine the p53 dependence and the molecular mechanism of RITA-induced apoptosis in neuroblastoma, using cell viability assays, RNAi silencing, co-immunoprecipitation, qPCR, and Western blotting analysis. In vivo experiments were conducted to study the effect of RITA on human neuroblastoma xenografts in mice. RITA induced p53-dependent apoptosis in a set of seven neuroblastoma cell lines, carrying wild-type or mutant p53; it activated p53 and triggered the expression of proapoptotic p53 target genes. Importantly, p53 activated by RITA inhibited several key oncogenes that are high-priority targets for pharmacologic anticancer strategies in neuroblastoma, including N-Myc, Aurora kinase, Mcl-1, Bcl-2, Wip-1, MDM2, and MDMX. Moreover, RITA had a strong antitumor effect in vivo. Reactivation of wild-type and mutant p53 resulting in the induction of proapoptotic factors along with ablation of key oncogenes by compounds such as RITA may be a highly effective strategy to treat neuroblastoma. ©2013 AACR.

  9. 33 CFR 110.250 - St. Thomas Harbor, Charlotte Amalie, V.I.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Thomas Harbor, Charlotte... SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.250 St. Thomas Harbor, Charlotte Amalie.... Thomas, V.I. of the United States and approaches thereto, including all waters under its jurisdiction, as...

  10. A new perspective on autism: Rita Leal School

    Directory of Open Access Journals (Sweden)

    Rodrigues T. F.

    2016-12-01

    Full Text Available Guided by the principle that scientific knowledge should serve to transform reality and create suitable conditions of life for all, the Portuguese Association for Relational-Historical Psychology (APPRH founded a school named RITA LEAL (RLS, with a therapeutic purpose based on new perspectives for treating autism — perspectives quite different from instrumental and behavioral learning programs. The Rita Leal School (Leal, 1975/2004, 1997, 2005, 2010 is rooted in the theory that mental development is based on a mutually contingent emotional relationship, while it underwrites Vygotsky’s concept of the Zone of Proximal Development (ZPD and Mediation (1930/2004, 1934/2009. Learning to read is a complex process which individuals with Autism Spectrum Disorder (ASD master slowly and with difficulty. We analyzed the process of learning to read of two ASD children accompanied by peers without special educational needs, aiming to pinpoint distinct aspects of their progress. We used the Observer Software Program to collect and analyze observations of their performance, which were understood as data to be classified according to previously specified codes. We believed we could demonstrate that, especially in the case of ASD children, learning is dependent on contingent responses and adequate levels of mediation. The technical team at the RLS has continuous clinical supervision. That is because we believe this supervision is what permits the team to undergo a process of de-centering, becoming more empathic and accessible to the autists. This makes the team’s intervention more efficient, because it becomes more aware of each autist’s individual characteristics, and therefore more available to respond to the autist’s needs.

  11. An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005)

    Science.gov (United States)

    2012-08-01

    of Hurricane Hugo (1989). Mon. Wea. Rev., 136, 1237–1259. Martinez, Y., G. Brunet, and M. K. Yau, 2010: On the dynamics of two-dimensional hurricane ...An Axisymmetric View of Concentric Eyewall Evolution in Hurricane Rita (2005) MICHAEL M. BELL Naval Postgraduate School, Monterey, California, and... Hurricane Research Division, Miami, Florida WEN-CHAU LEE National Center for Atmospheric Research,* Boulder, Colorado (Manuscript received 23 June 2011, in

  12. Bathymetry (2011) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution depth surface for the St. Thomas East End Reserve (STEER), St. Thomas in the...

  13. Lessons learned from the deadly sisters: drug and alcohol treatment disruption, and consequences from Hurricanes Katrina and Rita.

    Science.gov (United States)

    Maxwell, Jane Carlisle; Podus, Deborah; Walsh, David

    2009-01-01

    This paper reports on the effects of Hurricanes Katrina and Rita on drug and alcohol treatment in Texas in 2005-2006. Findings are based on a secondary analysis of administrative data on 567 hurricane-related admissions and on interview data from a sample of 20 staff in 11 treatment programs. Katrina evacuees differed from Rita clients in terms of demographics and primary problem substances and treatment needs, while the experiences of program staff and needed changes to improve disaster readiness were more similar. Additional systematic research is needed to document the intermediate and long-term impacts of the storms in these and other affected areas.

  14. Sweet resin bush on the Santa Rita Experimental Range: An eradication effort

    Science.gov (United States)

    Larry D. Howery; Bruce D. Munda; Dan G. Robinett; Harry H. Buck

    2003-01-01

    Sweet resin bush (Euryops subcarnosus DC ssp. vulgaris B. Nord; or, Euryops multifidis (L. f.) DC.), a South African shrub introduced to Arizona in the 1930s, was discovered on the Santa Rita Experimental Range (SRER) in 1998. Due to the threat of spread of this invasive plant and its potential to cause adverse environmental and economic effects, and because it posed a...

  15. 76 FR 20032 - Thomas E. Mitchell, M.D.; Dismissal of Proceeding

    Science.gov (United States)

    2011-04-11

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-7] Thomas E. Mitchell, M.D... Control, Drug Enforcement Administration, issued an Order to Show Cause to Thomas E. Mitchell, M.D....100(b) and 0.104, I hereby order that the Order to Show Cause issued to Thomas E. Mitchell, M.D., be...

  16. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    DEFF Research Database (Denmark)

    Bahl, Christian Robert Haffenden; Lefmann, Kim; Abrahamsen, Asger Bech

    2006-01-01

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator...

  17. Meie seast on lahkunud saksa keele tõlk Rita Tasa : [3.12.1930-16.07.2007

    Index Scriptorium Estoniae

    2007-01-01

    Järelhüüe kirjandusteadlasele, Tartu Ülikooli saksa kirjanduse õppejõule, Tallinna Pedagoogilise Instituudi saksa ja maailmakirjanduse õppejõule, saksa keele kadeedri juhatajale, saksa, šveitsi ning austria kirjanduse tõlkijale Rita Tasale

  18. 75 FR 68350 - Fischer, Thomas J.; Notice of Filing

    Science.gov (United States)

    2010-11-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6422-000] Fischer, Thomas J.; Notice of Filing October 29, 2010. Take notice that on October 29, 2010, Thomas J. Fischer filed an Application for Authorization to Hold Interlocking Positions as Director of Wisconsin Electric...

  19. Llewellyn Hilleth Thomas: An appraisal of an under-appreciated polymath

    Science.gov (United States)

    Jackson, John David

    2010-02-01

    Llewellyn Hilleth Thomas was born in 1903 and died in 1992 at the age of 88. His name is known by most for only two things, Thomas precession and the Thomas-Fermi atom. The many other facets of his career - astrophysics, atomic and molecular physics, nonlinear problems, accelerator physics, magnetohydrodynamics, computer design principles and software and hardware - are largely unknown or forgotten. I review his whole career - his early schooling, his time at Cambridge, then Copenhagen in 1925-26, and back to Cambridge, his move to the US as an assistant professor at Ohio State University in 1929, his wartime years at the Ballistic Research Laboratory, Aberdeen Proving Grounds, then in 1946 his new career as a unique resource at IBM's Watson Scientific Computing Laboratory and Columbia University until his first retirement in 1968, and his twilight years at North Carolina State University. Although the Thomas precession and the Thomas-Fermi atom may be the jewels in his crown, his many other accomplishments add to our appreciation of this consummate applied mathematician and physicist. )

  20. 76 FR 9012 - Favinger, Thomas G.; Notice of Filing

    Science.gov (United States)

    2011-02-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6223-002] Favinger, Thomas G.; Notice of Filing Take notice that on January 31, 2011 Thomas G. Favinger submitted for filing, an application for authority to hold interlocking positions, pursuant to Section 305(b) of the...

  1. Rita Felski, The Limits of Critique

    Directory of Open Access Journals (Sweden)

    Corrado Confalonieri

    2017-05-01

    Full Text Available Professore di Letteratura inglese presso la University of Virginia – e dal 2016 Niels Bohr Professor alla University of Southern Denmark per un progetto quinquennale dedicato agli usi sociali della letteratura –, Rita Felski non è, all’interno del gruppo di studiosi che lavorano negli Stati Uniti, tra quelli più noti al pubblico italiano, e ciò non soltanto perché mancano traduzioni dei suoi libri, ma per il fatto che diversi tra questi sono rivolti a un contesto piuttosto specificamente americano. Non fa eccezione The Limits of Critique, il libro che qui si presenta e che dovrebbe costituire la seconda uscita di una trilogia avviata nel 2008 con Uses of Literature (Wiley-Blackwell e destinata a concludersi con un volume ora in fase di elaborazione dedicato al coinvolgimento estetico e alle ragioni per cui, come lettori o spettatori, siamo affascinati da un’opera d’arte.

  2. Thomas precession in time

    International Nuclear Information System (INIS)

    Strnad, J.

    1983-01-01

    A Thomas precession mechanism is described which would become effective in a symmetric six-dimensional space-time if the time vector of a particle would rotate uniformly. For the effect a discrepancy of the decay time of particles in flight, proportional to their kinetic energy would be characteristic

  3. Hurricane Rita Aerial Photography: High-Resolution Imagery of the Texas and Louisiana Gulf Coast After Landfall

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The imagery posted on this site is of the Texas and Louisiana Gulf Coast after Hurricane Rita made landfall. The regions photographed range from San Luis Pass, Texas...

  4. 75 FR 22770 - Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment

    Science.gov (United States)

    2010-04-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13652-000-Montana] Gary E. Hall and Rita Hall; Notice of Availability of Environmental Assessment April 22, 2010. In accordance with the National Environmental Policy Act of 1969, as amended, and the Federal Energy Regulatory...

  5. Thomas Mann som bibelfortolker

    DEFF Research Database (Denmark)

    Nielsen, Kirsten

    2007-01-01

    Artiklen beskæftiger sig med Thomas Manns reception og transformation af den gammeltestamentlige fortælling om Josef og hans brødre. Særlig interesse samler sig om de gudsbilleder, værket indeholder, herunder relationen til Satan. Det karakteristiske ved Manns gudsbillede er, at Gud ikke er tydelig...

  6. Morgan, Prof. Thomas Hunt

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1939 Honorary. Morgan, Prof. Thomas Hunt Nobel Laureate (Medicine) - 1933. Date of birth: 25 September 1866. Date of death: 4 December 1945. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  7. Happy Birthday, Thomas Edison!

    Science.gov (United States)

    Dalton, Edward A.

    1997-01-01

    Discusses the work and inventions of Thomas Edison and their use in making teachers and students aware of the importance of electrotechnology in their lives and in their futures. Enables students to learn about science, experimentation, research, the process of invention, and the thrill of discovery. Describes educational resources available from…

  8. Praost Thomas Vaga 70 / Juhan Simonson ; foto: Juhan Simonson

    Index Scriptorium Estoniae

    Simonson, Juhan, 1933-2012

    2008-01-01

    8. märtsil 70 aastaseks saavast üle 20 aasta kirikuõpetajana New Jerseys ja New Yorgis teeninud praost Thomas Vagast. President Toomas Hendrik Ilves annetas iseseisvuspäeva puhul Thomas Vagale kui eestluse hoidjale Ameerika Ühendriikides ja kirikuelu edendajale Valgetähe IV klassi teenetemärgi

  9. The provenance and Sm/Nd Model ages of siliciclastic supracrustal rocks of the Faina and Santa Rita Greenstone belts, Goias, Brazil

    International Nuclear Information System (INIS)

    Resende, Marcelo Goncalves; Jost, Hardy; Lima, Bruno Eustaquio Moreira; Teixeira, Alexandre de Amorim

    1999-01-01

    The Faina and Santa Rita greenstone belts are two N 60 deg C W trending synclinoria separated by a N 30 deg C E strike-slip fault and rest allochtonous on the adjacent Uva and Caicara granite-gneiss complexes. The belts are made up of lower metakomatiites, followed by metabasalts and thick metasedimentary sequences deposited under contrasting paleogeographic settings. In Faina, the sequence consists of two complete shelf cycles, the first resting on basalts by an erosional unconformity. In Santa Rita, the basalts give gradually place to carbonaceous metashales, unconformably overlain by metarhythmites. Provenance based on trace element geochemistry, mineral chemistry of chloride and muscovite, source-are modeling and REE elements indicate that protoliths of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita formed under the influence of a source area dominated by mafic ultramafic rocks, whilst during the sedimentation of the second shelf cycle and the metarhythmites of Santa Rita the source-area was dominated by TTG granitoids. Sm-Nd model ages of the lower sedimentary packages vary between 3.0 and 2.8 Ga and the upper between 2.7 and 2.6 Ga. These intervals coincide, respectively, with the estimated age of the underlying, and with the Sm-Nd, Rb-Sr e U-Pb ages of the main granitoids and gneisses of the adjacent complexes. The same data indicate that, during the sedimentation of the first shelf cycle of Faina and the carbonaceous metashales of Santa Rita, both basins had independent source-areas, but shared the same source during the upper sections. Weathering nature and intensity of the source-area calculated by means of geochemical a data suggest that the dramatic change of provenance from the lower to the upper sections is due to the shift from tectonically stable to unstable regimes, interpreted as resulting from the emergence of the island arc whose roots are represented by the adjacent granite-gneiss complexes. (author)

  10. Iron status determination in pregnancy using the Thomas plot.

    Science.gov (United States)

    Weyers, R; Coetzee, M J; Nel, M

    2016-04-01

    Physiological changes during pregnancy affect routine tests for iron deficiency. The reticulocyte haemoglobin equivalent (RET-He) and serum-soluble transferrin receptor (sTfR) assay are newer diagnostic parameters for the detection of iron deficiency, combined in the Thomas diagnostic plot. We used this plot to determine the iron status of pregnant women presenting for their first visit to an antenatal clinic in Bloemfontein, South Africa. Routine laboratory tests (serum ferritin, full blood count and C-reactive protein) and RET-He and sTfR were performed. The iron status was determined using the Thomas plot. For this study, 103 pregnant women were recruited. According to the Thomas plot, 72.8% of the participants had normal iron stores and erythropoiesis. Iron-deficient erythropoiesis was detected in 12.6%. A third of participants were anaemic. Serum ferritin showed excellent sensitivity but poor specificity for detecting depleted iron stores. HIV status had no influence on the iron status of the participants. Our findings reiterate that causes other than iron deficiency should be considered in anaemic individuals. When compared with the Thomas plot, a low serum ferritin is a sensitive but nonspecific indicator of iron deficiency. The Thomas plot may provide useful information to identify pregnant individuals in whom haematologic parameters indicate limited iron availability for erythropoiesis. © 2015 John Wiley & Sons Ltd.

  11. Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation.

    Science.gov (United States)

    Ma, Teng; Yamada, Shumpei; Ichwan, Solachuddin J A; Iseki, Sachiko; Ohtani, Kiyoshi; Otsu, Megumi; Ikeda, Masa-Aki

    2012-01-20

    The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53-mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p53 (wt-p53) function by its gene transfer or by p53-reactivating small molecules has been extensively investigated. The p53-reactivating compounds Nutlin-3 and RITA activate p53 in the absence of genotoxic stress by antagonizing the action of its negative regulator Mdm2. Although controversial, Nutlin-3 was shown to induce p53-mediated apoptosis in a manner independent of p53 phosphorylation. Recently, RITA was shown to induce apoptosis by promoting p53Ser46 phosphorylation. Here we examined whether Nutlin-3 or RITA can overcome resistance to p53-mediated apoptosis in p53-resistant tumor cell lines lacking the ability to phosphorylate p53Ser46. We show that Nutlin-3 did not rescue the apoptotic defect of a Ser46 phosphorylation-defective p53 mutant in p53-sensitive tumor cells, and that RITA neither restored p53Ser46 phosphorylation nor induced apoptosis in p53Ser46 phosphorylation-deficient cells retaining wt-p53. Furthermore, treatment with Nutlin-3 or RITA together with adenoviral p53 gene transfer also failed to induce apoptosis in p53Ser46 phosphorylation-deficient cells either expressing or lacking wt-p53. These results indicate that neither Nutlin-3 nor RITA in able to induce p53-mediated apoptosis in the absence of p53Ser46 phosphorylation. Thus, the dysregulation of this phosphorylation in tumor cells may be a critical factor that limits the efficacy of these p53-based cancer therapies. Copyright © 2011 Elsevier Inc. All rights reserved.

  12. Time-dependent Thomas-Fermi approach to nuclear monopole oscillations

    International Nuclear Information System (INIS)

    Pi, M.; Barranco, M.; Nemeth, J.; Ngo, C.; Tomasi, E.

    1985-10-01

    A Time-dependent Thomas-Fermi (TDTF) method has been used to study nuclear monopole oscillations and in particular, the semiclassical strength function S(E). An analysis of the S(E) moments, obtained by suitable integrations, shows that these results are in good agreement with data previously obtained from static Thomas-Fermi calculations

  13. LiDAR Relative Reflectivity Surface (2011) for the St. Thomas East End Reserve, St. Thomas

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a LiDAR (Light Detection & Ranging) 0.3x0.3 meter resolution relative seafloor reflectivity surface for the St. Thomas East End Reserve...

  14. Orthophoto Mosaic (2012) of the St. Thomas East End Reserve

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This 0.3x0.3 meter imagery mosaic of the St. Thomas East End Reserve (STEER), St. Thomas in the U.S. Virgin Islands was created by the National Oceanic and...

  15. Matrix models and stochastic growth in Donaldson-Thomas theory

    Energy Technology Data Exchange (ETDEWEB)

    Szabo, Richard J. [Department of Mathematics, Heriot-Watt University, Colin Maclaurin Building, Riccarton, Edinburgh EH14 4AS, United Kingdom and Maxwell Institute for Mathematical Sciences, Edinburgh (United Kingdom); Tierz, Miguel [Grupo de Fisica Matematica, Complexo Interdisciplinar da Universidade de Lisboa, Av. Prof. Gama Pinto, 2, PT-1649-003 Lisboa (Portugal); Departamento de Analisis Matematico, Facultad de Ciencias Matematicas, Universidad Complutense de Madrid, Plaza de Ciencias 3, 28040 Madrid (Spain)

    2012-10-15

    We show that the partition functions which enumerate Donaldson-Thomas invariants of local toric Calabi-Yau threefolds without compact divisors can be expressed in terms of specializations of the Schur measure. We also discuss the relevance of the Hall-Littlewood and Jack measures in the context of BPS state counting and study the partition functions at arbitrary points of the Kaehler moduli space. This rewriting in terms of symmetric functions leads to a unitary one-matrix model representation for Donaldson-Thomas theory. We describe explicitly how this result is related to the unitary matrix model description of Chern-Simons gauge theory. This representation is used to show that the generating functions for Donaldson-Thomas invariants are related to tau-functions of the integrable Toda and Toeplitz lattice hierarchies. The matrix model also leads to an interpretation of Donaldson-Thomas theory in terms of non-intersecting paths in the lock-step model of vicious walkers. We further show that these generating functions can be interpreted as normalization constants of a corner growth/last-passage stochastic model.

  16. Matrix models and stochastic growth in Donaldson-Thomas theory

    International Nuclear Information System (INIS)

    Szabo, Richard J.; Tierz, Miguel

    2012-01-01

    We show that the partition functions which enumerate Donaldson-Thomas invariants of local toric Calabi-Yau threefolds without compact divisors can be expressed in terms of specializations of the Schur measure. We also discuss the relevance of the Hall-Littlewood and Jack measures in the context of BPS state counting and study the partition functions at arbitrary points of the Kähler moduli space. This rewriting in terms of symmetric functions leads to a unitary one-matrix model representation for Donaldson-Thomas theory. We describe explicitly how this result is related to the unitary matrix model description of Chern-Simons gauge theory. This representation is used to show that the generating functions for Donaldson-Thomas invariants are related to tau-functions of the integrable Toda and Toeplitz lattice hierarchies. The matrix model also leads to an interpretation of Donaldson-Thomas theory in terms of non-intersecting paths in the lock-step model of vicious walkers. We further show that these generating functions can be interpreted as normalization constants of a corner growth/last-passage stochastic model.

  17. 33 CFR 165.762 - Security Zone; St. Thomas, U.S. Virgin Islands.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; St. Thomas, U.S....762 Security Zone; St. Thomas, U.S. Virgin Islands. (a) Location. Moving and fixed security zones are established 50 yards around all cruise ships entering, departing, moored or anchored in the Port of St. Thomas...

  18. Vascular plants and a brief history of the Kiowa and Rita Blanca National Grasslands

    Science.gov (United States)

    Donald L. Hazlett; Michael H. Schiebout; Paulette L. Ford

    2009-01-01

    Administered by the USDA Forest Service, the Kiowa and Rita Blanca National Grasslands occupy 230,000 acres of public land extending from northeastern New Mexico into the panhandles of Oklahoma and Texas. A mosaic of topographic features including canyons, plateaus, rolling grasslands and outcrops supports a diverse flora. Eight hundred twenty six (826) species of...

  19. Environmental Impact Report from Santa Rita Hydroelectric Power Plant (Minas Gerais State - Brazil): technical strategic for its elaboration; Relatorio de Impacto Ambiental da Usina Hidreletrica da Santa Rita (MG): estrategica tecnica para sua elaboracao

    Energy Technology Data Exchange (ETDEWEB)

    Souza, J.A. de; Marques Neto, F P [Companhia Energetica de Minas Gerais (CEMIG), Belo Horizonte, MG (Brazil)

    1990-12-31

    The steps for developing the technical strategies used on the elaboration of Environmental Impact Report from Santa Rita Hydroelectric Power Plant, Minas Gerais State, are described, including the influence area, technical requirements, impact identification, technical selection of mitigative measures, impact meaning and strategy for evaluating the identified impacts. (C.G.C.).

  20. saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription.

    Science.gov (United States)

    Portnoy, Victoria; Lin, Szu Hua Sharon; Li, Kathy H; Burlingame, Alma; Hu, Zheng-Hui; Li, Hao; Li, Long-Cheng

    2016-03-01

    Small activating RNAs (saRNAs) targeting specific promoter regions are able to stimulate gene expression at the transcriptional level, a phenomenon known as RNA activation (RNAa). It is known that RNAa depends on Ago2 and is associated with epigenetic changes at the target promoters. However, the precise molecular mechanism of RNAa remains elusive. Using human CDKN1A (p21) as a model gene, we characterized the molecular nature of RNAa. We show that saRNAs guide Ago2 to and associate with target promoters. saRNA-loaded Ago2 facilitates the assembly of an RNA-induced transcriptional activation (RITA) complex, which, in addition to saRNA-Ago2 complex, includes RHA and CTR9, the latter being a component of the PAF1 complex. RITA interacts with RNA polymerase II to stimulate transcription initiation and productive elongation, accompanied by monoubiquitination of histone 2B. Our results establish the existence of a cellular RNA-guided genome-targeting and transcriptional activation mechanism and provide important new mechanistic insights into the RNAa process.

  1. The RITA spectrometer at Risø - Design considerations and recent results

    DEFF Research Database (Denmark)

    Clausen, K.N.; McMorrow, D.F.; Lefmann, K.

    1998-01-01

    In the new cold triple axis spectrometer RITA at Riso we have improved the front end by extensive use of state of the art optical elements and better shielding material. The analyser system is situated in one large open tank and consists of seven individually orientable PC(002) crystal analyser b...... by a study of the spin fluctuations in the high T-c superconductor La1.83Sr0.17CuO4. (C) 1998 Elsevier Science B.V. All rights reserved....

  2. "Making Lemonade from Lemons:" Early Childhood Teacher Educators' Programmatic Responses to Hurricanes Katrina and Rita

    Science.gov (United States)

    DiCarlo, Cynthia F.; Burts, Diane C.; Buchanan, Teresa K.; Aghayan, Carol; Benedict, Joan

    2007-01-01

    This article describes how early childhood teacher education faculty at one university responded in the aftermath of hurricanes Katrina and Rita and used the disaster to enhance their undergraduate and graduate programs. They explain how they modeled developmentally appropriate practices while responding to community needs. Four companion articles…

  3. Archive and laboratory embedded in the landscape: Future of the Santa Rita Experimental Range

    Science.gov (United States)

    Thomas E. Sheridan

    2003-01-01

    The Santa Rita Experimental Range (SRER) is both an archive of past ecological research and a laboratory for continuing research embedded in the southern Arizona landscape. The scientific questions being asked there have changed over the last 100 years, but SRER with its monitoring stations and its legacy of repeat photography still offers a unique opportunity to study...

  4. Rangeland livestock production: Developing the concept of sustainability on the Santa Rita Experimental Range

    Science.gov (United States)

    George B. Ruyle

    2003-01-01

    The Santa Rita Experimental Range (SRER) was established in 1903 at the behest of concerned stockmen and researchers as the first facility in the United States set aside to study range livestock production. At the time, severe overgrazing of the public domain had seriously reduced carrying capacities of Southwestern rangelands. Researchers on the SRER developed and...

  5. Katrina and Rita were lit up with lightning

    Science.gov (United States)

    Shao, X.-M.; Harlin, J.; Stock, M.; Stanley, M.; Regan, A.; Wiens, K.; Hamlin, T.; Pongratz, M.; Suszcynsky, D.; Light, T.

    Hurricanes generally produce very little lightning activity compared to other noncyclonic storms, and lightning is especially sparse in the eye wall and inner regions within tens of kilometers surrounding the eye [Molinari et al., 1994, 1999]. (The eye wall is the wall of clouds that encircles the eye of the hurricane.) Lightning can sometimes be detected in the outer, spiral rainbands, but the lightning occurrence rate varies significantly from hurricane to hurricane as well as within an individual hurricane's lifetime.Hurricanes Katrina and Rita hit the U.S. Gulf coasts of Louisiana, Mississippi, and Texas, and their distinctions were not just limited to their tremendous intensity and damage caused. They also differed from typical hurricanes in their lightning production rate.

  6. The effect of proximity to hurricanes Katrina and Rita on subsequent hurricane outlook and optimistic bias.

    Science.gov (United States)

    Trumbo, Craig; Lueck, Michelle; Marlatt, Holly; Peek, Lori

    2011-12-01

    This study evaluated how individuals living on the Gulf Coast perceived hurricane risk after Hurricanes Katrina and Rita. It was hypothesized that hurricane outlook and optimistic bias for hurricane risk would be associated positively with distance from the Katrina-Rita landfall (more optimism at greater distance), controlling for historically based hurricane risk and county population density, demographics, individual hurricane experience, and dispositional optimism. Data were collected in January 2006 through a mail survey sent to 1,375 households in 41 counties on the coast (n = 824, 60% response). The analysis used hierarchal regression to test hypotheses. Hurricane history and population density had no effect on outlook; individuals who were male, older, and with higher household incomes were associated with lower risk perception; individual hurricane experience and personal impacts from Katrina and Rita predicted greater risk perception; greater dispositional optimism predicted more optimistic outlook; distance had a small effect but predicted less optimistic outlook at greater distance (model R(2) = 0.21). The model for optimistic bias had fewer effects: age and community tenure were significant; dispositional optimism had a positive effect on optimistic bias; distance variables were not significant (model R(2) = 0.05). The study shows that an existing measure of hurricane outlook has utility, hurricane outlook appears to be a unique concept from hurricane optimistic bias, and proximity has at most small effects. Future extension of this research will include improved conceptualization and measurement of hurricane risk perception and will bring to focus several concepts involving risk communication. © 2011 Society for Risk Analysis.

  7. Comment on “An algorithm for identification and classification of individuals with type 1 and type 2 diabetes mellitus in a large primary care database”, written by Sharma et al

    Directory of Open Access Journals (Sweden)

    Bocquet V

    2017-01-01

    Full Text Available Valéry Bocquet Competence Center for Methodology and Statistics, Luxembourg Institute of Health, LuxembourgDiabetes is a disease whose global prevalence has been rising year after year, and by 2014 more than 400 million individuals were diagnosed with diabetes.1 As a consequence, screening of patients with type 1 or type 2 diabetes has become important, both to estimate the prevalence of diabetes and to treat affected individuals. For that purpose, a two-step algorithm suggested by Sharma et al2 was recently published, whose aims were to identify type 1 or type 2 individuals from a primary care database. The first step of the algorithm was based on the diagnostic records, treatment given, and results obtained from clinical tests. The second part was based on the combination of diagnostic codes, prescribed medications, age at the time of diagnosis, and finally whether the case was prevalent or incident.View original paper by Sharma et al

  8. The Structure and Function of Male Thomas Langur Loud Calls

    NARCIS (Netherlands)

    Wich, Serge Alexander

    2002-01-01

    This study has addressed the acoustical structure of male loud calls and their function in Thomas langur social organisation. Thomas langurs are medium sized primate that lives in Sumatra, Indonesia. Ome of the characteristics of this species is the loud call of males. Several functions for loud

  9. A token of individuality : Questiones libri Porphirii by Thomas Manlevelt

    NARCIS (Netherlands)

    Helm, Alfred Charles van der

    2012-01-01

    This is a critical edition with introduction and indices of the Questiones libri Porphirii, a commentary on Porphyry’s Isagoge attributed to the fourteenth-century logician Thomas Manlevelt. Not much is known about Thomas Manlevelt, but his work is remarkable enough. Following in the footsteps of

  10. Positive Traits versus Previous Trauma: Racially Different Correlates with PTSD Symptoms among Hurricane Katrina-Rita Volunteers

    Science.gov (United States)

    Ai, Amy L.; Plummer, Carol; Kanno, Hanae; Heo, Grace; Appel, Hoa B.; Simon, Cassandra E.; Spigner, Clarence

    2011-01-01

    This study compared risks and protective factors for acquiring symptoms of posttraumatic stress disorder (PTSD) between African-American (n = 299) and European-American (n = 206) student volunteers 3 months after Hurricanes Katrina and Rita (H-KR). Respondents retrospectively provided information on peritraumatic emotional reactions and previous…

  11. Morphological responses of the Wax Lake Delta, Louisiana, to Hurricanes Rita

    Directory of Open Access Journals (Sweden)

    Fei Xing

    2017-12-01

    Full Text Available This study examines the morphodynamic response of a deltaic system to extreme weather events. The Wax Lake Delta (WLD in Louisiana, USA, is used to illustrate the impact of extreme events (hurricanes on a river-dominated deltaic system. Simulations using the open source Delft3D model reveal that Hurricane Rita, which made landfall 120 km to the west of WLD as a Category 3 storm in 2005, caused erosion on the right side and deposition on the left side of the hurricane eye track on the continental shelf line (water depth 10 m to 50 m. Erosion over a wide area occurred both on the continental shelf line and in coastal areas when the hurricane moved onshore, while deposition occurred along the Gulf coastline (water depth < 5 m when storm surge water moved back offshore. The numerical model estimated that Hurricane Rita’s storm surge reached 2.5 m, with maximum currents of 2.0 m s–1, and wave heights of 1.4 m on the WLD. The northwestern-directed flow and waves induced shear stresses, caused erosion on the eastern banks of the deltaic islands and deposition in channels located west of these islands. In total, Hurricane Rita eroded more than 500,000 m3 of sediments on the WLD area. Including waves in the analysis resulted in doubling the amount of erosion in the study area, comparing to the wave-excluding scenario. The exclusion of fluvial input caused minor changes in deltaic morphology during the event. Vegetation cover was represented as rigid rods in the model which add extra source terms for drag and turbulence to influence the momentum and turbulence equations. Vegetation slowed down the floodwater propagation and decreased flow velocity on the islands, leading to a 47% reduction in the total amount of erosion. Morphodynamic impact of the hurricane track relative to the delta was explored. Simulations indicate that the original track of Hurricane Rita (landfall 120 km west of the WLD produced twice as much erosion and deposition at the delta

  12. Professionaalne marketing - edu pant / Thomas Westerberg

    Index Scriptorium Estoniae

    Westerberg, Thomas

    1999-01-01

    Majanduslanguse perioodil tuleb fokusseerida oma plaanid tulevikku, sel perioodil avalduvad turundusjuhtide tõelised ja varjatud professionaalsed oskused. Thomas Westerbergi, Coca-Cola Baltic Beverages Ltd. tegevdirektori ettekanne Majanduskonverentsil "Kuidas olla edukas majanduslanguse perioodil"

  13. Orkaan Rita ähvardab rüüstata USA naftatööstuse südame / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2005-01-01

    Orkaan Rita läheneb USA naftatööstuse südamele Texasele, kus toodetakse veerand USA naftatoodetest. Diagramm: Naftafirmade aktsiate tõus. Vt. samas: Bensiini hinna olulist tõusu Eestis prognoosida oleks ennatlik

  14. Mammals of medium and large size in Santa Rita do Sapucaí, Minas Gerais, southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Eduardo, A. A.

    2009-01-01

    Full Text Available The diversity of Brazilian vertebrates is regarded among the highest in the world. However, the biologicaldiversity is still mostly unknown and a good part of it is seriously threatened by human activities. This study aimed toinventory the medium and large size mammals present in the Reserva Biológica de Santa Rita do Sapucaí, an Atlanticforest reserve located in Santa Rita do Sapucaí, southeastern Brazil. Sand-plots, photographic traps and searches foranimal tracks on pre-existent trails in the area, were carried out once every two months between May 2006 andFebruary 2007. The sand-plots and tracks were inspected during five consecutive days per sampling. We obtained 108records of 15 species, mostly of carnivorans. Two confirmed species are threatened with extinction in Brazil (Callithrixaurita and Leopardus pardalis. The results suggest that the sampled reserve has high species richness and plays animportant role in conservation of mammals in this landscape, including species threatened with extinction.

  15. California: 'the Stem Cell State'. Interview with Jonathan Thomas.

    Science.gov (United States)

    Thomas, Jonathan

    2011-11-01

    We talked to Jonathan Thomas, newly elected Chairman of the California Institute for Regenerative Medicine (CIRM), a few weeks into a role he describes as "the opportunity of the lifetime" to find out what he sees as the key goals for the CIRM and why patient advocates are so critical to the future of the Institute. Jonathan Thomas was elected as Chairman of the California Institute for Regenerative Medicine (CIRM) in June 2011, succeeding the Founder and former Chairman, Bob Klein. Thomas has had a successful career in finance and law and is a Co-Founding Partner at Saybrook Capital, an investment banking and private equity firm. His commitment to patient advocacy and keen interest in biological sciences, developed as a Biology Major at Yale, led him to stand for Chairman.

  16. Nonextensive Thomas-Fermi model

    Science.gov (United States)

    Shivamoggi, Bhimsen; Martinenko, Evgeny

    2007-11-01

    Nonextensive Thomas-Fermi model was father investigated in the following directions: Heavy atom in strong magnetic field. following Shivamoggi work on the extension of Kadomtsev equation we applied nonextensive formalism to father generalize TF model for the very strong magnetic fields (of order 10e12 G). The generalized TF equation and the binding energy of atom were calculated which contain a new nonextensive term dominating the classical one. The binding energy of a heavy atom was also evaluated. Thomas-Fermi equations in N dimensions which is technically the same as in Shivamoggi (1998) ,but behavior is different and in interesting 2 D case nonextesivity prevents from becoming linear ODE as in classical case. Effect of nonextensivity on dielectrical screening reveals itself in the reduction of the envelope radius. It was shown that nonextesivity in each case is responsible for new term dominating classical thermal correction term by order of magnitude, which is vanishing in a limit q->1. Therefore it appears that nonextensive term is ubiquitous for a wide range of systems and father work is needed to understand the origin of it.

  17. Transformative experiences for Hurricanes Katrina and Rita disaster volunteers.

    Science.gov (United States)

    Clukey, Lory

    2010-07-01

    The massive destruction caused by Hurricanes Katrina and Rita in 2005 provided an opportunity for many volunteers to be involved with disaster relief work. Exposure to devastation and personal trauma can have long-lasting and sometimes detrimental effects on people providing help. This qualitative study explored the experience of volunteer relief workers who provided disaster relief services after the hurricanes. Three major themes emerged: emotional reactions that included feelings of shock, fatigue, anger and grief as well as sleep disturbances; frustration with leadership; and life-changing personal transformation. Stress reactions were noted but appeared to be mitigated by feelings of compassion for the victims and personal satisfaction in being able to provide assistance. Suggestions are provided for further research.

  18. Missed by the Mass Media: The Houma, Pointe-au-Chien, and Hurricanes Katrina and Rita

    Science.gov (United States)

    Collins, Robert Keith

    2008-01-01

    This case study investigates the media discourse from Houma and Pointe-au-Chien tribal leaders in Louisiana on their experiences with Hurricanes Katrina and Rita. One section briefly engages the discourse as discernable from the reports found in Native American and non-Native American news media. Included is a brief yet close examination of these…

  19. From the incident command center oil spills from Hurricanes Katrina and Rita

    Energy Technology Data Exchange (ETDEWEB)

    Guidry, R.J. [Lousiana Oil Spill Coordinator' s Office, Baton Rouge, LA (United States)

    2006-07-01

    Approximately 30.2 million litres of oil were discharged during Hurricanes Katrina and Rita. A total of 230 incidents were reported to the state's spill response community, including ruptured pipelines, damaged and moved storage tanks, refineries, and sunken vessels. By January 2006, industry had reported the recovery of 14.7 million litres of oil. After Hurricane Rita, a further 234 off- and onshore incidents were reported. This paper presented a chronology from August 26 2005 through to June 2006 of clean-up activities for both hurricanes, with specific reference to logistic and communications issues associated with working in environments that are difficult to access due to damaged transportation infrastructure. An outline of the Louisiana Oil Spill Coordinator's Office's role in the incidents was presented, as well as an overview of the Louisiana State Contingency Plan. It was noted that the lack of communications systems caused considerable difficulties for responders. It was concluded that responses to hurricanes can be made more effective by having all response communities incident command structure (ICS)-trained with a thorough knowledge of the National Response Plan as it relates to the National Contingency Plan. Ensuring that plans are operational, having clear lines of authority on all hurricane-related issues, and having a robust communications plan were recommended, as well as the ability to respond without communications.

  20. From the incident command center oil spills from Hurricanes Katrina and Rita

    International Nuclear Information System (INIS)

    Guidry, R.J.

    2006-01-01

    Approximately 30.2 million litres of oil were discharged during Hurricanes Katrina and Rita. A total of 230 incidents were reported to the state's spill response community, including ruptured pipelines, damaged and moved storage tanks, refineries, and sunken vessels. By January 2006, industry had reported the recovery of 14.7 million litres of oil. After Hurricane Rita, a further 234 off- and onshore incidents were reported. This paper presented a chronology from August 26 2005 through to June 2006 of clean-up activities for both hurricanes, with specific reference to logistic and communications issues associated with working in environments that are difficult to access due to damaged transportation infrastructure. An outline of the Louisiana Oil Spill Coordinator's Office's role in the incidents was presented, as well as an overview of the Louisiana State Contingency Plan. It was noted that the lack of communications systems caused considerable difficulties for responders. It was concluded that responses to hurricanes can be made more effective by having all response communities incident command structure (ICS)-trained with a thorough knowledge of the National Response Plan as it relates to the National Contingency Plan. Ensuring that plans are operational, having clear lines of authority on all hurricane-related issues, and having a robust communications plan were recommended, as well as the ability to respond without communications

  1. Sir John Meurig Thomas.

    Science.gov (United States)

    Thomas, John Meurig

    2013-10-11

    "My greatest achievement has been to combine being a teacher, a researcher, and a popularizer of science for over 50 years. My worst nightmare is to find myself dumbstruck when I am about to give a lecture …︁" This and more about Sir John Meurig Thomas can be found on page 10938. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. The role of surfactants in the formulation of elastic liposomal gels containing a synthetic opioid analgesic

    OpenAIRE

    Singh, Sima; Vardhan, Harsh; Kotla, Niranjan G; Maddiboyina, Balaji; Sharma, Dinesh; Webster, Thomas J

    2016-01-01

    Sima Singh,1,* Harsh Vardhan,1,* Niranjan G Kotla,2 Balaji Maddiboyina,3 Dinesh Sharma,4 Thomas J Webster5,6 1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India; 2Center for Research in Medical Devices, National University of Ireland, Galway, Ireland; 3Department of Pharmaceutics, Vishwabharathi College of Pharmaceutical Sciences, Guntur, India; 4Ranbaxy Laboratory Ltd, Gurgaon, India; 5Department of Chemical Engineering, Northeastern University, Boston, MA, U...

  3. Student Rights, Clarence Thomas, and the Revolutionary Vision of Education

    Science.gov (United States)

    Warnick, Bryan R.; Rowe, Bradley; Kim, Sang Hyun

    2009-01-01

    In his concurring opinion to the 2007 U.S. Supreme Court decision, "Morse v. Frederick," Justice Clarence Thomas argues that the "Tinker" decision, which granted students constitutional rights in public schools, should be overturned on originalist grounds. In this essay, Bryan Warnick, Bradley Rowe, and Sang Hyun Kim make the case that Thomas's…

  4. Spatial-temporal water quality parameters evaluation of the Santa Rita river (BA with respect to the release of manipueira

    Directory of Open Access Journals (Sweden)

    Franklin Delano Porto Júnior

    2012-12-01

    Full Text Available The watershed of the river Santa Rita includes the towns of Simão and Campinhos, where exists about 150 flour houses. Campinhos is among the largest cassava processing facilities in the region, generating many direct and indirect jobs. Manipueira is a liquid residue originating from the cassava pressing and presents high pollutant potential due to its high amount of glucose and fructose, this potential is 25 times greater than the one from domestic sewer. This work had as objective the evaluation of possible impacts of manipueira release in the water quality of Santa Rita river. For this, the land use map was elaborated and the physiographic characterization developed, besides being performed six campaigns for water samples collection in four sampling points along the river. The obtained results indicated that the watershed is elongated, with low drainage efficiency and it is not prone to flooding. Estimated water quality parameters indicated that organic effluents from Campinhos and Simão impact the values of dissolved oxygen, electrical conductivity, salinity, ammonia, nitrite, nitrate and zinc, suggesting that the water quality of the river Santa Rita is affected by manipueira release. The concentrations of total phosphorus, iron and cooper were superior downstream of the Sewer Treatment Station. The river water was saline in the three sampling points most affected by the release of manipueira.

  5. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  6. A Cáritas brasileira e a Economia Popular Solidária: O Agente de Cáritas e a Caridade Libertadora (Brazilian Caritas and the Popular Solidarity Economy: The Agent of Caritas and the Charity Liberating) - DOI: 10.5752/P.2175-5841.2013v11n32p1506

    OpenAIRE

    Joannes Paulus Silva Forte; Alicia Ferreira Gonçalves

    2013-01-01

    O presente artigo analisa as ligações entre a Cáritas Brasileira e a Economia Popular Solidária a partir do trabalho do Agente de Cáritas. A problemática central do artigo remete às representações sociais que esses Agentes constroem em seus relatos sobre os princípios da Teologia da Libertação que norteiam os projetos em economia solidária da referida instituição religiosa. A metodologia de base qualitativa e etnográfica consistiu na realização da revisão bibliográfica, consulta a materiais i...

  7. Von Weizsaecker and exchange corrections in the Thomas Fermi theory

    International Nuclear Information System (INIS)

    Benguria, R.D.

    1979-01-01

    Two corrections to the Thomas-Fermi theory of atoms are studied. First the correction for exchange, that is the effect of the Pauli principle in the interaction energy, is considered. The defining variational problem is non-convex and standard technique to prove existence of a minimizing solution do not apply. Existence and uniqueness of solutions are established by convexifying or relaxing the energy functional. Properties of the minimizing solution are studied. A second correction due to von Weizsaecker is also discussed. Finally the dual principle to the Thomas-Fermi variational problem is studied (only in the neutral case). A dual principle is suggested for the ionic case. Also, a review of recent rigorous results concerning Thomas-Fermi theory is presented

  8. Thomas Aquinas on Contingency of Nature

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Petr

    2008-01-01

    Roč. 5, č. 2 (2008), s. 185-196 ISSN 1214-8407 R&D Projects: GA AV ČR(CZ) IAA900090602 Institutional research plan: CEZ:AV0Z90090514 Keywords : Thomas Aquinas * determinism * contingency Subject RIV: AA - Philosophy ; Religion

  9. Martineau, Harriet. - Mistry, Rohinton. - Peacock, Thomas Love

    OpenAIRE

    Beck, Rudolf

    2002-01-01

    Martineau, Harriet. - Mistry, Rohinton. - Peacock, Thomas Love. - In: Metzler-Lexikon englischsprachiger Autorinnen und Autoren / hrsg. von Eberhard Kreutzer ... - Stuttgart u.a. : Metzler, 2002. - S. 384, 405 f., 452 f.

  10. Dissolved and colloidal trace elements in the Mississippi River delta outflow after Hurricanes Katrina and Rita

    Science.gov (United States)

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-07-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn-O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02-0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the bioavailablity

  11. Thomas-Fermi model of warm nuclei

    International Nuclear Information System (INIS)

    Buchler, J.R.; Epstein, R.I.

    1980-01-01

    The average nuclear level density of spherical nuclei is computed with a finite temperature Thomas-Fermi model. More than 80% of the low energy nuclear excitations can be accounted for in terms of this statistical model. The relevance for stellar collapse is discussed

  12. 77 FR 51564 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-24

    ... Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington... of human remains under the control of the Thomas Burke Memorial Washington State Museum (Burke Museum...

  13. Thomas Mofolo: the man, the writer and his contexts | Gill | Tydskrif ...

    African Journals Online (AJOL)

    For example, as a boy, we learn that Thomas imbibed a great deal from his father Abner Ramofolo Mofolo, a very hard-working and practically-oriented man, who was himself a gifted storyteller. Given the possibility of pursuing higher studies through the Protestant PEMS Mission, Thomas grabbed this opportunity and came ...

  14. Impact of hurricanes katrina and rita on the anesthesiology workforce.

    Science.gov (United States)

    Hutson, Larry R; Vega, Jorge; Schubert, Armin

    2011-01-01

    Hurricanes Katrina and Rita impacted a large portion of the medical community in Louisiana. We attempt to determine their impact on the anesthesiology workforce in Louisiana. In May 2006, a survey was mailed to 368 Louisiana anesthesiologists, collecting demographic data, retirement plans, impact of Hurricanes Katrina and Rita, position vacancies, practice conditions, and the general state of healthcare in their area. All 3 anesthesiology residency programs in the state were contacted regarding their recent graduates. The 2010 RAND survey of the anesthesiology workforce was reviewed with respect to findings relevant to the state and region. One hundred seventy surveys were returned, yielding a 46.2% response rate. Among the respondents, 13.9% intended to retire within 5 years and another 24% in 5 to 10 years. Since 2005, 63.9% had seen an increase in their daily caseload, 46.9% saw an increase in work hours, and 36.8% stated that their practices were trying to hire new anesthesiologists and were having difficulty filling these positions. Since 2005, the number of anesthesiology residents in Louisiana had declined by almost 50%, and the number of graduates remaining to practice in Louisiana had decreased by 43% from 7 to 4 annually. Our 2006 survey provided qualitative evidence for a shortage of anesthesiologists in the state of Louisiana after the natural disasters in 2005 that was likely to worsen as residency output plummeted, fewer residents stayed in the state, and projected retirement increased. The regional data from the RAND survey a year later confirmed the impressions from our survey, with an estimate of an anesthesiologist shortage as high as 39% of the workforce. State membership surveys may serve as accurate barometers in the wake of major environmental upheavals affecting regional anesthesiology workforce conditions.

  15. Practicing like Thomas Edison.

    Science.gov (United States)

    Baum, Neil; Ornstein, Hal

    2013-01-01

    For many centuries, medicine has practiced in a vacuum, and the healthcare profession has been isolated from other scientific disciplines. Beginning in the 20th century, doctors and scientists have looked to others for ideas, suggestions, innovations, and new technologies. Probably no one in the past hundred years has done so much to change the world than Thomas Edison. This article will discuss eight principles of Edison and how they may apply to our profession and our practices.

  16. 78 FR 19632 - Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St...

    Science.gov (United States)

    2013-04-02

    ...-AA08 Special Local Regulations; St. Thomas Carnival Watersport Activities, Charlotte Amalie Harbor; St... proposes to establish a special local regulation on the waters of Charlotte Amalie Harbor in St Thomas, USVI during the St. Thomas Carnival Watersport Activities, a high speed boat race. The event is...

  17. The monochromatic imaging mode of a RITA-type neutron spectrometer

    International Nuclear Information System (INIS)

    Bahl, C.R.H.; Andersen, P.; Klausen, S.N.; Lefmann, K.

    2004-01-01

    The imaging monochromatic mode of a neutron spectrometer with a multi-bladed RITA analyser system is so far unexplored. We present analytical calculations that define the mode. It is shown that the mode can be realised for PG (0 0 2) analyser crystals, from incident energies of about 3.2 meV and up, allowing the important cases of 3.7, 5.0 and 13.7 meV. Due to beam divergence, the neutron rays from neighbouring analyser blades are found to overlap slightly. Hence, the optimal use of the monochromatic imaging mode would be found by employing an adjustable radial collimator to limit the spread of the ray from each analyser blade

  18. The monochromatic imaging mode of a RITA-type neutron spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Bahl, C.R.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark) and Department of Physics, Technical University of Denmark, DK-2800 Lyngby (Denmark)]. E-mail: christian.bahl@risoe.dk; Andersen, P. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Klausen, S.N. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Lefmann, K. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)

    2004-12-01

    The imaging monochromatic mode of a neutron spectrometer with a multi-bladed RITA analyser system is so far unexplored. We present analytical calculations that define the mode. It is shown that the mode can be realised for PG (0 0 2) analyser crystals, from incident energies of about 3.2 meV and up, allowing the important cases of 3.7, 5.0 and 13.7 meV. Due to beam divergence, the neutron rays from neighbouring analyser blades are found to overlap slightly. Hence, the optimal use of the monochromatic imaging mode would be found by employing an adjustable radial collimator to limit the spread of the ray from each analyser blade.

  19. Mapping Hurricane Rita inland storm tide

    Science.gov (United States)

    Berenbrock, Charles; Mason, Jr., Robert R.; Blanchard, Stephen F.; Simonovic, Slobodan P.

    2009-01-01

    Flood-inundation data are most useful for decision makers when presented in the context of maps of effected communities and (or) areas. But because the data are scarce and rarely cover the full extent of the flooding, interpolation and extrapolation of the information are needed. Many geographic information systems (GIS) provide various interpolation tools, but these tools often ignore the effects of the topographic and hydraulic features that influence flooding. A barrier mapping method was developed to improve maps of storm tide produced by Hurricane Rita. Maps were developed for the maximum storm tide and at 3-hour intervals from midnight (0000 hour) through noon (1200 hour) on September 24, 2005. The improved maps depict storm-tide elevations and the extent of flooding. The extent of storm-tide inundation from the improved maximum storm-tide map was compared to the extent of flood-inundation from a map prepared by the Federal Emergency Management Agency (FEMA). The boundaries from these two maps generally compared quite well especially along the Calcasieu River. Also a cross-section profile that parallels the Louisiana coast was developed from the maximum storm-tide map and included FEMA high-water marks.

  20. Thomas: o primeiro blanchotiano = Thomas: the first Blanchotian

    Directory of Open Access Journals (Sweden)

    Pimentel, Davi Andrade

    2013-01-01

    Full Text Available Este artigo analisa a narrativa Thomas l’obscur, de Maurice Blanchot, a partir da configuração da outra noite blanchotiana, noite que apresenta a falta e a ausência da palavra no que ela tem de mais agressiva, de mais excessiva e de mais absurdamente maravilhosa. Neste artigo, tenho como interlocutor teórico os escritos sobre literatura do próprio autor. O interesse nesse diálogo consiste em apresentar a fusão apaixonada de seus escritos ficcionais e teóricos. Em Maurice Blanchot, não há pontos de isolamento e nem de divergência entre seus dois pólos de escritura, mas sim uma complementação, uma convergência, entre o que denominamos de ficção e de teoria

  1. Cholera in Thomas Mann's Death in Venice.

    Science.gov (United States)

    Rütten, Thomas

    2009-01-01

    The article sets the cholera motif in Thomas Mann's famous novella Death in Venice against the historical context from which it partially originates. It is shown that this motif, while undoubtedly appropriated to serve Mann's own poetic ends, has a solid grounding in historical and autobiographical fact, thus blurring the boundaries between fact and fiction. The article illustrates the verifiable events of the outbreak of the Venetian cholera epidemic in May 1911, which Mann partly witnessed himself, during a holiday trip to Brioni and Venice, and partly heard and read about. It is established that Thomas Mann's account of the cholera in Venice in his novella is characterised by a rare and almost preternatural insightfulness into an otherwise murky affair that was marked by rumours, speculations and denials.

  2. Crossing Canadian Cultural Borders: A study of the Aboriginal/White Stereotypical Relations in George Ryga's The Ecstasy of Rita Joe

    Directory of Open Access Journals (Sweden)

    Maram M. Samman

    2017-12-01

    Full Text Available This paper traces the intercultural journey of a young Aboriginal girl into the hegemonic white society. Rita Joe crossed the imaginary border that separates her reserve from the other Canadian society living in the urban developed city. Through this play, George Ryga aims at achieving liberation and social equality for the Aboriginals who are considered a colonized minority in their land. The research illustrates how Ryga represented his personal version of the colonial Aboriginal history to provide an empowering body narrative that supports their identity in the present and resists the erosion of their culture and tradition. The play makes very strong statements to preserve the family, history and local heritage against this forced assimilation. It tells the truth as its playwright saw it. The play is about the trail of Rita Joe after she moved from her reserve in pursuit of the illusion of the city where she thought she would find freedom and social equality. In fact the audience and the readers are all on trial. Ryga is pointing fingers at everyone who is responsible for the plights of the Aboriginals as it is clear in the play. He questions the Whites’ stereotypical stand against the Aboriginals. The play is a direct criticism of the political, social and cultural systems in Canada. The paper reveals Aboriginals' acts of opposition to racism, assimilation and colonization as represented in The Ecstasy of Rita Joe.

  3. Thomas Jefferson and the Purposes of Education.

    Science.gov (United States)

    Jewett, Thomas O.

    1997-01-01

    Thomas Jefferson was the first conspicuous U.S. advocate of free education supported by local taxation and of state aid to higher education. He believed that only an educated citizenry could assume the responsibilities of self-government. (SK)

  4. Caribbean ST Thomas trap Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  5. Safety Performance Improvement for Nuclear Power Plants Utilizing THOMAS

    International Nuclear Information System (INIS)

    Kim, Won June; Ryu, Jung Uk; Suh, Kune Y.

    2005-01-01

    THOMAS (Thermal Hydraulics Online Monitoring Advisory System) is equipped with a couple of salient features compared with existing monitoring systems. The first has to do with the three-dimensional (3D) visualization technique to support the nuclear power plant (NPP) operators and personnel using the virtual reality (VR) technology. VR depicts an environment simulated by a computer. Most of the VR environments primarily include visual experiences, displayed either on a monitor or though special stereoscopic goggles. Users can often interactively manipulate a VR environment, either through standard input devices like a keyboard, or through specially designed devices like a cybergloves. Additional devices were not applied the in THOMAS. The visualized model file is brought to the VR space from the computer-aided design (CAD) tool. In the VR space, using mapping, the component color is changed with linked value of the safety variables. Operators thus can easily recognize the plant condition. This is related with the human factor engineering. The second is the function of decision making using the influence diagram logic. The influence diagram logic is based on the total probability and Bayesian theory. The accident modeling is rooted in the emergency operating procedure (EOP). The final goal of this system is, in the accident situation, to present a success path to the operator for the recovery of the NPP system. At the current developing level, the database signals THOMAS. In other words, a spectrum of system analysis codes provides the safety parameter values to the database, which are subsequently supplied to THOMAS through the network

  6. Environmental Impact Report from Santa Rita Hydroelectric Power Plant (Minas Gerais State - Brazil): technical strategic for its elaboration

    International Nuclear Information System (INIS)

    Souza, J.A. de; Marques Neto, F.P.

    1989-01-01

    The steps for developing the technical strategies used on the elaboration of Environmental Impact Report from Santa Rita Hydroelectric Power Plant, Minas Gerais State, are described, including the influence area, technical requirements, impact identification, technical selection of mitigative measures, impact meaning and strategy for evaluating the identified impacts. (C.G.C.)

  7. Mapping and Visualization of Storm-Surge Dynamics for Hurricane Katrina and Hurricane Rita

    Science.gov (United States)

    Gesch, Dean B.

    2009-01-01

    The damages caused by the storm surges from Hurricane Katrina and Hurricane Rita were significant and occurred over broad areas. Storm-surge maps are among the most useful geospatial datasets for hurricane recovery, impact assessments, and mitigation planning for future storms. Surveyed high-water marks were used to generate a maximum storm-surge surface for Hurricane Katrina extending from eastern Louisiana to Mobile Bay, Alabama. The interpolated surface was intersected with high-resolution lidar elevation data covering the study area to produce a highly detailed digital storm-surge inundation map. The storm-surge dataset and related data are available for display and query in a Web-based viewer application. A unique water-level dataset from a network of portable pressure sensors deployed in the days just prior to Hurricane Rita's landfall captured the hurricane's storm surge. The recorded sensor data provided water-level measurements with a very high temporal resolution at surveyed point locations. The resulting dataset was used to generate a time series of storm-surge surfaces that documents the surge dynamics in a new, spatially explicit way. The temporal information contained in the multiple storm-surge surfaces can be visualized in a number of ways to portray how the surge interacted with and was affected by land surface features. Spatially explicit storm-surge products can be useful for a variety of hurricane impact assessments, especially studies of wetland and land changes where knowledge of the extent and magnitude of storm-surge flooding is critical.

  8. Usefulness of the admission electrocardiogram to predict long-term outcomes after non-ST-elevation acute coronary syndrome (from the FRISC II, ICTUS, and RITA-3 [FIR] Trials)

    DEFF Research Database (Denmark)

    Damman, Peter; Holmvang, Lene; Tijssen, Jan G P

    2012-01-01

    Instability in Coronary Artery Disease (FRISC II), Invasive Versus Conservative Treatment in Unstable Coronary Syndromes (ICTUS), and Randomized Intervention Trial of Unstable Angina 3 (RITA-3) patient-pooled database, 5,420 patients with NSTE-ACS with qualitative ECG data, of whom 2,901 had quantitative data...... the addition of quantitative characteristics to a model including qualitative characteristics. In conclusion, in the FRISC II, ICTUS, and RITA-3 NSTE-ACS patient-pooled data set, admission ECG characteristics provided long-term prognostic value for cardiovascular death or myocardial infarction. Quantitative...

  9. Traumatic Loss and Natural Disaster: A Case Study of a School-Based Response to Hurricanes Katrina and Rita

    Science.gov (United States)

    Clettenberg, Stacey; Gentry, Judy; Held, Matthew; Mock, Lou Ann

    2011-01-01

    This article tracks the trajectory and impact of Hurricanes Katrina and Rita on the communities of Houston/Harris County, Texas, USA, the schools, children, and families; along with the community partnerships that addressed the trauma and upheaval. Following the influx of individuals and families who were displaced by Hurricanes Katrina and Rita…

  10. Dissolved and colloidal trace elements in the Mississippi River Delta outflow after Hurricanes Katrina and Rita

    Science.gov (United States)

    Shim, Moo-Joon; Swarzenski, Peter W.; Shiller, Alan M.

    2012-01-01

    The Mississippi River delta outflow region is periodically disturbed by tropical weather systems including major hurricanes, which can terminate seasonal bottom water hypoxia and cause the resuspension of shelf bottom sediments which could result in the injection of trace elements into the water column. In the summer of 2005, Hurricanes Katrina and Rita passed over the Louisiana Shelf within a month of each other. Three weeks after Rita, we collected water samples in the Mississippi River delta outflow, examining the distributions of trace elements to study the effect of Hurricanes Katrina and Rita. We observed limited stratification on the shelf and bottom waters that were no longer hypoxic. This resulted, for instance, in bottom water dissolved Mn being lower than is typically observed during hypoxia, but with concentrations still compatible with Mn–O2 trends previously reported. Interestingly, for no element were we able to identify an obvious effect of sediment resuspension on its distribution. In general, elemental distributions were compatible with previous observations in the Mississippi outflow system. Co and Re, which have not been reported for this system previously, showed behavior consistent with other systems: input for Co likely from desorption and conservative mixing for Re. For Cs, an element for which there is little information regarding its estuarine behavior, conservative mixing was also observed. Our filtration method, which allowed us to distinguish the dissolved (<0.02 μm) from colloidal (0.02–0.45 μm) phase, revealed significant colloidal fractions for Fe and Zn, only. For Fe, the colloidal phase was the dominant fraction and was rapidly removed at low salinity. Dissolved Fe, in contrast, persisted out to mid-salinities, being removed in a similar fashion to nitrate. This ability to distinguish the smaller Fe (likely dominantly organically complexed) from larger colloidal suspensates may be useful in better interpreting the

  11. Thomas Vicary, barber-surgeon.

    Science.gov (United States)

    Thomas, Duncan P

    2006-05-01

    An Act of Parliament in 1540 uniting the barbers and surgeons to form the Barber-Surgeons' Company represented an important foundation stone towards better surgery in England. Thomas Vicary, who played a pivotal role in promoting this union, was a leading surgeon in London in the middle of the 16th century. While Vicary made no direct contribution to surgical knowledge, he should be remembered primarily as one who contributed much towards the early organization and teaching of surgery and to the consequent benefits that flowed from this improvement.

  12. del Nido versus St. Thomas Cardioplegia Solutions: A Single-Center Retrospective Analysis of Post Cross-Clamp Defibrillation Rates.

    Science.gov (United States)

    Buel, Shane T; Striker, Carrie Whittaker; O'Brien, James E

    2016-06-01

    There are many cardioplegia solutions currently in use for pediatric cardiopulmonary bypass (CPB). The most common being del Nido solution. Another common cardioplegia solution used for pediatric CPB is St. Thomas. In October 2014, Children's Mercy Kansas City changed from the use of modified St. Thomas to del Nido. This study compared rates of post cross-clamp fibrillation requiring defibrillation between del Nido solution and modified St. Thomas solution stratified by weight at Children's Mercy Kansas City. This retrospective study consisted of 394 patients who underwent cardiac surgery requiring cardioplegia between January 1, 2014 and July 31, 2015. The outcome measured was defibrillation upon cross-clamp removal. Statistical significance was determined using Fishers exact test with a two-sided significance level of .05. Incidence of defibrillation post cross-clamp removal was 4.4% in the del Nido group and 26.8% in the St. Thomas group (p Thomas group (p Thomas group (p Thomas group (p 60-kg category had an incidence of defibrillation of 16.7% in the del Nido group and 63% in the St. Thomas group (p Thomas and del Nido cardioplegia solutions. Analyses of weight stratifications demonstrate a decrease in the rate of defibrillation post cross-clamp removal in all categories within the del Nido group.

  13. Satellite Images and Aerial Photographs of the Effects of Hurricanes Katrina and Rita on Coastal Louisiana

    Science.gov (United States)

    Barras, John A.

    2007-01-01

    Introduction Hurricane Katrina made landfall on the eastern coastline of Louisiana on August 29, 2005; Hurricane Rita made landfall on the western coastline of Louisiana on September 24, 2005. Comparison of Landsat Thematic Mapper (TM) satellite imagery acquired before and after the landfalls of Katrina and Rita and classified to identify land and water demonstrated that water area increased by 217 mi2 (562 km2) in coastal Louisiana as a result of the storms. Approximately 82 mi2 (212 km2) of new water areas were in areas primarily impacted by Hurricane Katrina (Mississippi River Delta basin, Breton Sound basin, Pontchartrain basin, and Pearl River basin), whereas 99 mi2 (256 km2) were in areas primarily impacted by Hurricane Rita (Calcasieu/Sabine basin, Mermentau basin, Teche/Vermilion basin, Atchafalaya basin, and Terrebonne basin). Barataria basin contained new water areas caused by both hurricanes, resulting in some 18 mi2 (46.6 km2) of new water areas. The fresh marsh and intermediate marsh communities' land areas decreased by 122 mi2 (316 km2) and 90 mi2 (233.1 km2), respectively, and the brackish marsh and saline marsh communities' land areas decreased by 33 mi2 (85.5 km2) and 28 mi2 (72.5 km2), respectively. These new water areas represent land losses caused by direct removal of wetlands. They also indicate transitory changes in water area caused by remnant flooding, removal of aquatic vegetation, scouring of marsh vegetation, and water-level variation attributed to normal tidal and meteorological variation between satellite images. Permanent losses cannot be estimated until several growing seasons have passed and the transitory impacts of the hurricanes are minimized. The purpose of this study was to provide preliminary information on water area changes in coastal Louisiana acquired shortly after the landfalls of both hurricanes (detectable with Landsat TM imagery) and to serve as a regional baseline for monitoring posthurricane wetland recovery. The land

  14. New Jersey's Thomas Edison and the fluoroscope.

    Science.gov (United States)

    Tselos, G D

    1995-11-01

    Thomas Edison played a major role in the development of early x-ray technology in 1896, notably increasing tube power and reliability and making the fluoroscope a practical instrument. Eventually, Edison would move x-ray technology from the laboratory to the marketplace.

  15. Thomas Hiärne - nimi Rootsi Läänemereprovintside varasest ajalookirjutusest / Piret Lotman

    Index Scriptorium Estoniae

    Lotman, Piret, 1950-

    2008-01-01

    Thomase isa Erlandi karjäärist. Thomas Hiärne headest suhetest Eestimaa kindralkuberneri Bengt Horniga. Thomas Hiärne kandideerimisest Ingerimaa rüütelkonna sekretäri kohale. Tema tegevusest Virtsu mõisa inspektorina. Hiärne kroonikast ja ajalookäsitlusest

  16. Thomas precession for dressed particles

    Science.gov (United States)

    Oblak, Blagoje

    2018-03-01

    We consider a particle dressed with boundary gravitons in three-dimensional Minkowski space. The existence of BMS transformations implies that the particle’s wavefunction picks up a Berry phase when subjected to changes of reference frames that trace a closed path in the asymptotic symmetry group. We evaluate this phase and show that, for BMS superrotations, it provides a gravitational generalization of Thomas precession. In principle, such phases are observable signatures of asymptotic symmetries.

  17. Initial management of hospital evacuations caused by Hurricane Rita: a systematic investigation.

    Science.gov (United States)

    Downey, Erin L; Andress, Knox; Schultz, Carl H

    2013-06-01

    Hurricanes remain a major threat to hospitals throughout the world. The authors attempted to identify the planning areas that impact hospital management of evacuations and the challenges faced when sheltering-in-place. This observational, retrospective cohort study examined acute care institutions from one hospital system impacted by Hurricane Rita in 2005. Investigators used a standardized survey instrument and interview process, previously used in the hospital evacuation context, to examine hospitals' initial internal situational awareness and subsequent decision making that resulted in evacuation due to Hurricane Rita. Participants from each hospital included representatives from senior leadership and clinical and nonclinical staff that comprised the Incident Management Team (IMT). The main measured outcomes were responses to 95 questions contained in the survey. Seven of ten eligible hospitals participated in the study. All facilities evacuated the sickest patients first. The most significant factors prompting evacuation were the issuing of mandatory evacuation orders, storm dynamics (category, projected path, storm surge), and loss of regional communications. Hospitals that sheltered-in-place experienced staff shortages, interruptions to electrical power, and loss of water supplies. Three fully-evacuated institutions experienced understaffing of 40%-60%, and four hospitals sustained depressed staffing levels for over four weeks. Five hospitals lost electricity for a mean of 4.8 days (range .5-11 days). All facilities continued to receive patients to their Emergency Departments (EDs) while conducting their own evacuation. Hospital EDs should plan for continuous patient arrival during evacuation. Emergency Operation Plans (EOPs) that anticipate challenges associated with evacuation will help to maximize initial decision making and management during a crisis situation. Hospitals that shelter-in-place face critical shortages and must provide independent patient

  18. Mold exposure and health effects following hurricanes Katrina and Rita.

    Science.gov (United States)

    Barbeau, Deborah N; Grimsley, L Faye; White, LuAnn E; El-Dahr, Jane M; Lichtveld, Maureen

    2010-01-01

    The extensive flooding in the aftermath of Hurricanes Katrina and Rita created conditions ideal for indoor mold growth, raising concerns about the possible adverse health effects associated with indoor mold exposure. Studies evaluating the levels of indoor and outdoor molds in the months following the hurricanes found high levels of mold growth. Homes with greater flood damage, especially those with >3 feet of indoor flooding, demonstrated higher levels of mold growth compared with homes with little or no flooding. Water intrusion due to roof damage was also associated with mold growth. However, no increase in the occurrence of adverse health outcomes has been observed in published reports to date. This article considers reasons why studies of mold exposure after the hurricane do not show a greater health impact.

  19. The Ecclesiological Contributions of Thomas Helwys’s Reformation in a Baptist Context

    Directory of Open Access Journals (Sweden)

    Jones Marvin

    2017-12-01

    Full Text Available The English Separatist movement provided the background for which John Smyth and Thomas Helwys emerged to reconstitute a biblical ecclesiology. Through the study of the New Testament, they came to the position that infant baptism and covenantal theology could not be the foundation for the New Testament church. Both men embraced believer’s baptism as the basic foundation in which a recovered church should be built. Unfortunately, Smyth defected to the Mennonites, leaving Thomas Helwys to continue the fledging work known as Baptists. This article will examine the life of Thomas Helwys and his contribution to Baptist ecclesiology; it will also review selected literary works that contributed to the recovery of a New Testament church and the founding of Baptist ecclesiology.

  20. Thomas van Aquino en de Thomas van Utrecht. Kritische kanttekeningen bij de Utrechtse lezing van de Summa Theologiae

    NARCIS (Netherlands)

    Aertsen, J.A.

    1994-01-01

    In the last decade a group of scholars at the Catholic University of Utrecht developed an approach of its own to Aquinas's Summa theologiae, which is named “the Utrecht hypothesis”. In section I this hypothesis is summarized in eight propositions. Its main elements are twofold. (A) Thomas does not

  1. Hurricane Rita and the destruction of Holly Beach, Louisiana: Why the chenier plain is vulnerable to storms

    Science.gov (United States)

    Sallenger, A.H.; Wright, C.W.; Doran, K.; Guy, K.; Morgan, K.

    2009-01-01

    Hurricane Rita devastated gulf-front communities along the western Louisiana coast in 2005. LIDAR (light detection and ranging) topographic surveys and aerial photography collected before and after the storm showed the loss of every structure within the community of Holly Beach. Average shoreline change along western Louisiana's 140-km-long impacted shore was -23.3 ?? 30.1 m of erosion, although shoreline change in Holly Beach was substantially less, and erosion was not pervasive where the structures were lost. Before the storm, peak elevations of the dunes, or berms in the absence of dunes, along the impacted shore averaged 1.6 m. The storm surge, which reached 3.5 m just east of Holly Beach, completely inundated the beach systems along the impacted western Louisiana shore. The high surge potential and low land elevations make this coast extremely vulnerable to hurricanes. In fact, most of the western Louisiana shore impacted by Rita will be completely inundated by the storm surge of a worst-case Saffi r-Simpson category 1 hurricane. All of this shore will be inundated by worst-case category 2-5 storms. ?? 2009 The Geological Society of America.

  2. Instantons, quivers and noncommutative Donaldson-Thomas theory

    Science.gov (United States)

    Cirafici, Michele; Sinkovics, Annamaria; Szabo, Richard J.

    2011-12-01

    We construct noncommutative Donaldson-Thomas invariants associated with abelian orbifold singularities by analyzing the instanton contributions to a six-dimensional topological gauge theory. The noncommutative deformation of this gauge theory localizes on noncommutative instantons which can be classified in terms of three-dimensional Young diagrams with a colouring of boxes according to the orbifold group. We construct a moduli space for these gauge field configurations which allows us to compute its virtual numbers via the counting of representations of a quiver with relations. The quiver encodes the instanton dynamics of the noncommutative gauge theory, and is associated to the geometry of the singularity via the generalized McKay correspondence. The index of BPS states which compute the noncommutative Donaldson-Thomas invariants is realized via topological quantum mechanics based on the quiver data. We illustrate these constructions with several explicit examples, involving also higher rank Coulomb branch invariants and geometries with compact divisors, and connect our approach with other ones in the literature.

  3. Instantons, quivers and noncommutative Donaldson-Thomas theory

    Energy Technology Data Exchange (ETDEWEB)

    Cirafici, Michele, E-mail: cirafici@math.ist.utl.pt [Centro de Analise Matematica, Geometria e Sistemas Dinamicos, Departamento de Matematica, Instituto Superior Tecnico, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Sinkovics, Annamaria, E-mail: A.Sinkovics@damtp.cam.ac.uk [Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA (United Kingdom); Szabo, Richard J., E-mail: R.J.Szabo@ma.hw.ac.uk [Department of Mathematics, Heriot-Watt University, Colin Maclaurin Building, Riccarton, Edinburgh EH14 4AS (United Kingdom); Maxwell Institute for Mathematical Sciences, Edinburgh (United Kingdom)

    2011-12-11

    We construct noncommutative Donaldson-Thomas invariants associated with abelian orbifold singularities by analyzing the instanton contributions to a six-dimensional topological gauge theory. The noncommutative deformation of this gauge theory localizes on noncommutative instantons which can be classified in terms of three-dimensional Young diagrams with a colouring of boxes according to the orbifold group. We construct a moduli space for these gauge field configurations which allows us to compute its virtual numbers via the counting of representations of a quiver with relations. The quiver encodes the instanton dynamics of the noncommutative gauge theory, and is associated to the geometry of the singularity via the generalized McKay correspondence. The index of BPS states which compute the noncommutative Donaldson-Thomas invariants is realized via topological quantum mechanics based on the quiver data. We illustrate these constructions with several explicit examples, involving also higher rank Coulomb branch invariants and geometries with compact divisors, and connect our approach with other ones in the literature.

  4. Surveys in 1961 on St. Thomas & St. Croix

    DEFF Research Database (Denmark)

    Dahl, Thorkel; Licht, Kjeld de Fine

    Registration of towns and buildings erected during the Danish reign of the Caribbean Isles of St. Thomas, St. Jan and St. Croix 1671-1917 (now belonging to the USA under the name of Virgin Islands)....

  5. 75 FR 78335 - Culturally Significant Objects Imported for Exhibition Determinations: “Thomas Lawrence: Regency...

    Science.gov (United States)

    2010-12-15

    ... DEPARTMENT OF STATE [Public Notice 7268] Culturally Significant Objects Imported for Exhibition Determinations: ``Thomas Lawrence: Regency Power and Brilliance'' SUMMARY: Notice is hereby given of the... determine that the objects to be included in the exhibition ``Thomas Lawrence: Regency Power and Brilliance...

  6. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    International Nuclear Information System (INIS)

    Bahl, C.R.H.; Lefmann, K.; Abrahamsen, A.B.; Ronnow, H.M.; Saxild, F.; Jensen, T.B.S.; Udby, L.; Andersen, N.H.; Christensen, N.B.; Jakobsen, H.S.; Larsen, T.; Haefliger, P.S.; Streule, S.; Niedermayer, Ch.

    2006-01-01

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode

  7. Inelastic neutron scattering experiments with the monochromatic imaging mode of the RITA-II spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Bahl, C.R.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark) and Department of Physics, Technical University of Denmark, DK-2800 Lyngby (Denmark)]. E-mail: christian.bahl@risoe.dk; Lefmann, K. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark)]. E-mail: kim.lefmann@risoe.dk; Abrahamsen, A.B. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Ronnow, H.M. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Saxild, F. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Jensen, T.B.S. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Udby, L. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Andersen, N.H. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Christensen, N.B. [Department of Materials Research, Riso National Laboratory, Building 227, Frederiksborgvej 399, DK-4000 Roskilde (Denmark); Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Jakobsen, H.S. [Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Larsen, T. [Niels Bohr Institute for Astronomy, Physics and Geophysics, University of Copenhagen, DK-2100 Copenhagen (Denmark); Haefliger, P.S. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland); Streule, S.; Niedermayer, Ch. [Laboratory for Neutron Scattering, Paul Scherrer Institute, CH-5232 Villigen (Switzerland)

    2006-05-15

    Recently a monochromatic multiple data taking mode has been demonstrated for diffraction experiments using a RITA type cold neutron spectrometer with a multi-bladed analyser and a position-sensitive detector. Here, we show how this mode can be used in combination with a flexible radial collimator to perform real inelastic neutron scattering experiments. We present the results from inelastic powder, single crystal dispersion and single crystal constant energy mapping experiments. The advantages and complications of performing these experiments are discussed along with a comparison between the imaging mode and the traditional monochromatic focussing mode.

  8. Mineral, Energy, and Fertilizer Resources of the North Coast of Peru: Perspective from the Santa Rita B Archaeological Site

    Science.gov (United States)

    Brooks, William E.; Kent, Jonathan D.; Willett, Jason C.

    2004-01-01

    The Santa Rita B archaeological site is in the Chao Valley, approximately 65 km southeast of Trujillo, northern Peru. Location of Santa Rita B at the emergence of several drainages from the Andean cordillera is an important factor in the almost continuous occupation of the site over the past 3,000 years. Mineral resources are abundant throughout the Andes; however, the north coast of Peru was an important center for pre-Columbian mining, metallurgy, and craftsmanship. Success of the Chavin, Moche, Chimu, and other north coast cultures is directly related to the availability and exploitation of mineral and energy resources that include: gold (?silver), as electrum, mainly from placers, and copper from local oxide and carbonate occurrences and from sulfides related to copper porphyry occurrences in the cordillera. An alloy of these three metals is referred to as tumbaga, which is the primary material for Andean metalcraft. Anthracite was used for mirrors by north coast cultures and is available near Rio Chicama, Rio Santa, and east of Santa Rita B. These outcrops are a part of the Alto Chicama, Peru's largest coalfield, which extends from Rio Chicama, in the north, for 200 km southward to Rio Santa. Charcoal from the algorrobo tree and llama dung are considered to be the common pre-Columbian energy sources for cooking and metalwork; however, availability and the higher heat content of anthracite indicate that it was used in metallurgical applications. Bitumen is available from petroleum seeps near Talara, north of the study area, and may have been used as glue or as cement. Hematite, goethite, limonite, and manganese oxides from clay-altered volcanic rock may have provided color and material for ceramics. Guano from the Islas Gua?apes, Chinchas, and Ballestas was used as fertilizer for cotton and other crops.

  9. Caribbean ST Thomas all gears Logbook Survey (Vessels)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains catch (landed catch) and effort for fishing trips made by vessels fishing in St. Thomas. The catch and effort data for the entire trip are...

  10. Thomas Edison’s Poetry Machine

    OpenAIRE

    Rubery, Matthew

    2014-01-01

    The tradition of spoken-word recording began with Thomas Edison’s invention of the phonograph. Hence, this article makes the case that 1878 is a more important year to the history of literature than has yet been recognized for its experiments with verse and sound-recording technology. Although the tinfoil phonograph’s first decade has been well documented by media historians, literary critics have singled out 1888 as the noteworthy year since that is when Edison’s improved phonograph made it ...

  11. Mental Health, Substance Use, and Adaptive Coping among Social Work Students in the Aftermath of Hurricanes Katrina and Rita

    Science.gov (United States)

    Lemieux, Catherine M.; Plummer, Carol A.; Richardson, Roslyn; Simon, Cassandra E.; Ai, Amy L.

    2010-01-01

    The current study examined mental health symptomology, substance use, and adaptive coping among 416 social work students following Hurricanes Katrina and Rita. Among participants, 47% scored at or above the clinical level for depression, with 6% of students showing clinical PTSD-like symptoms, and 16.9% reporting substance use. Two thirds (66.9%)…

  12. Dylan Thomas's "25 Poems": Paradox as Structure

    Science.gov (United States)

    Bharadwaj, S.

    2014-01-01

    Irony, inclusiveness, and complexity are the chief criteria of value in the twentieth century intellectual poetry. These criteria, however, do not merely indicate qualities of craftsmanship; they reflect a sensibility, a particular way of experiencing reality. What really distinguishes Dylan Thomas is a capacity for self-analysis, a capacity for…

  13. Physical Holonomy, Thomas Precession, and Clifford Algebra

    International Nuclear Information System (INIS)

    Urbantke, H.

    1988-01-01

    After a general discussion of the physical significance of holonomy group transformations, a relation between the transports of Fermi-Walker and Levi-Civita in Special Relativity is pointed out. A well-known example -the Thomas-Wigner angle - is rederived in a completely frame-independent manner using Clifford algebra. 14 refs. (Author)

  14. Stratigraphy of the Charqueadas Carboniferous basin, Santa Rita, RS, Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mendes Piccoli, A.E.; Holz, M.; Munaro, P.

    1985-01-01

    Sedimentological analyses of about 80 drill cores from the Charqueadas - Santa Rita Coal Field, west of Porto Alegre, Rio Grande do Sul State, were made. The Itarare Group is characterized by pelites of lacustrine origin and conglomerates and sandstones of alluvial fans, mainly in the north western region. A shallow lacustrine and paludal system characterize the Rio Bonito Formation, comprising coal seams and associated pelitic sediments, as well as some paraconglomerates and sandstone layers. The contact between these units is established by the colour of the pelites, differences in sedimentary textures, structures and palynological data. A marine transgression caused the sediments of the Rio Bonito Formation to be covered by coastal sandstones and pelites of the Palermo Formation, of tidal flat origin. Today, the coal layers and sediments have been eroded southward and slope gently to the north of the area.

  15. The poor in the Epistle of James and the Gospel of Thomas

    Directory of Open Access Journals (Sweden)

    Patrick J. Hartin

    1997-12-01

    Full Text Available This study explores similarities in the thought world of the Epistle of James and the Gospel of Thomas. Particular attention is devoted to the role that the 'poor' and 'poverty' play in both documents. For the Epistle of James it is 'the poor in the world that God has chosen to be rich in faith and heirs of the kingdom' (Ja 2:5.  In a similar vein, in the Gospel of Thomas the kingdom is promised to those who have embraced the poverty of a radical life-style: 'Blessed are the poor, for yours is the kingdom of heaven' (GTh 54. This outlook betrays a basic ethos adopted toward the world. In both the Epistle of James and the Gospel of Thomas the relationship to the world ultimately determines one's relationship to the kingdom or to God. For the Epistle of James the very definition of religion demands that one keep 'oneself unstained from  the world' (Ja 1 :27 and that 'friendship with the world' is enmity with God (Ja 4:4. For the Gospel of Thomas the rejection of the world involves a radical ethos that embraces an intinerant life ('Be passersby' [GTh 42J, which includes a rejection of wealth (GTh 63.'If you do not abstain from the world, you will not find the kingdom' (GTh 27. It is argued that the Gospel of Thomas and the Epistle of James reflect traditional sayings that endorse a similar ethos of radical discipleship.

  16. A Model Technology Educator: Thomas A. Edison

    Science.gov (United States)

    Pretzer, William S.; Rogers, George E.; Bush, Jeffery

    2007-01-01

    Reflecting back over a century ago to the small village of Menlo Park, New Jersey provides insight into a remarkable visionary and an exceptional role model for today's problem-solving and design-focused technology educator: Thomas A. Edison, inventor, innovator, and model technology educator. Since Edison could not simply apply existing knowledge…

  17. Thomas of Wroclaw (1297-1378) - Medieval bishop and scholar of English origin.

    Science.gov (United States)

    Bieganowski, Lech; Grzybowski, Andrzej

    2017-11-01

    Peter of Tilleberi (Tilbury), later known as bishop Thomas of Wroclaw, after completing his studies (in Bologna or in Montpellier) worked as a physician in northern Italy and probably in Spain. Later through Germany and Bohemia, he came to Wroclaw in 1336 where he joined the Order of St. Dominic. In 1352, Thomas was made an auxiliary bishop of the diocese of Wroclaw. After the episcopal consecration, Thomas stopped living in the abbey, but all the time he was well known both as a priest and physician. He is known as an author of several treatises on medical sciences. His most important work entitled Michi competit (i.e. It suits me) is composed of four parts: Regimen sanitatis (i.e. Hygiene), Aggregatum (i.e. Aggregation), Antidotarium (i.e. Medicine directory) and Practica medicinalis (i.e. Medical practices). Moreover, he is the author of other treatises including, for example, De phlebotomia et de iudiciis cruoris (i.e. On phlebotomy and blood content) and De urinis (i.e. On urine). Some Polish scientists claim that bishop Thomas of Wroclaw with his knowledge and industriousness functioned as a university faculty of medicine even though the University of Cracow had not been established yet.

  18. Rising Above the Water: New Orleans Implements Energy Efficiency and Sustainability Practices Following Hurricanes Katrina and Rita (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2012-07-01

    This fact sheet describes the technical assistance that the U.S. Department of Energy, through its National Renewable Energy Laboratory, provided to New Orleans, Louisiana, which helped the city incorporate energy efficiency into its rebuilding efforts for K-12 schools and homes following Hurricanes Katrina and Rita. NREL also provided support and analysis on energy policy efforts.

  19. Cohomological gauge theory, quiver matrix models and Donaldson-Thomas theoryCohomological gauge theory, quiver matrix models and Donaldson-Thomas theory

    NARCIS (Netherlands)

    Cirafici, M.; Sinkovics, A.; Szabo, R.J.

    2009-01-01

    We study the relation between Donaldson–Thomas theory of Calabi–Yau threefolds and a six-dimensional topological Yang–Mills theory. Our main example is the topological U(N) gauge theory on flat space in its Coulomb branch. To evaluate its partition function we use equivariant localization techniques

  20. Thomas Piketty and the Justice of Education

    Science.gov (United States)

    Bøyum, Steinar

    2016-01-01

    Thomas Piketty's "Capital in the Twenty-First Century" is best known for its documentation of increasing social inequality, but it also has a notable normative aspect. Although Piketty is far less clear on the normative level than on the empirical, his view of justice can be summarised as meritocratic luck egalitarianism. This leads him…

  1. 75 FR 52023 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-08-24

    ... DEPARTMENT OF THE INTERIOR National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service... of the Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington...

  2. 75 FR 36672 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... DEPARTMENT OF THE INTERIOR National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service... of the Thomas Burke Memorial Washington State Museum (Burke Museum), University of Washington...

  3. UPANJE IN SVOBODA V DELU STEPHENA KINGA RITA HAYWORTH AND SHAWSHANK REDEMPTION IN ALEXANDRE DUMAS GROF MONTE CRISTO

    OpenAIRE

    Kramar, Vesna

    2011-01-01

    Rita Hayworth and Shawshank Redemption Stephena Kinga in Grof Monte Cristo Alexandra Dumasa izhajata iz različnih literarnih žanrov in se razlikujeta v dogajanju, a imata kljub temu podobno motiviko in tematiko. V obeh zgodbah je nedolžen mož poslan v zapor, iz katerega je pobeg skorajda nemogoč, a se kljub temu obema uspe izmuzniti iz zapora na podoben način

  4. 76 FR 58033 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum (Burke...

  5. 75 FR 36671 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2010-06-28

    ... DEPARTMENT OF THE INTERIOR National Park Service Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA; Correction AGENCY: National Park... human remains and associated funerary objects in the possession of the Thomas Burke Memorial Washington...

  6. 76 FR 58034 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum (Burke...

  7. 76 FR 58039 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum (Burke...

  8. Thomas Mofolo's sentence design in Chaka approached in translation

    African Journals Online (AJOL)

    Thomas Mofolo's sentence design in Chaka approached in translation. ... by responding to several compelling questions, ranging from how five translators of the work approached it in their respective languages ... AJOL African Journals Online.

  9. Teaching the "Leviathan": Thomas Hobbes on Education

    Science.gov (United States)

    Bejan, Teresa M.

    2010-01-01

    This paper considers Thomas Hobbes's educational thought both in its historical context and in the context of his political philosophy as a whole. It begins with Hobbes's diagnosis of the English Civil War as the product of the miseducation of the commonwealth and shows that education was a central and consistent concern of his political theory…

  10. Thomas Secker M.D.: Archbishop and man-midwife.

    Science.gov (United States)

    Morgan-Guy, John

    2018-05-01

    This paper provides a biographical outline of the career of Thomas Secker, MD, who from 1758-68 was Archbishop of Canterbury. Although much has been written on Secker, this study seeks to highlight his training in medicine, which has been largely overlooked hitherto by historians.

  11. Entrevista a María Rita Otero

    Directory of Open Access Journals (Sweden)

    Olga Lucia Castiblanco Abril

    2016-09-01

    Full Text Available OC: Dra. María Rita, bienvenida a esta sección de la revista en donde siempre queremos que nuestros lectores conozcan personas de la vida académica en el campo de la investigación en Enseñeanza de las Ciencias. En primer lugar, nos gustaría que nos contara algo sobre su lugar actual como docente e invstigadora. MRO: Muchas gracias por la invitación. Quisiera contarles que hasta hace dos años fui profesora de secundaria durante 33 años. Actualmente soy profesora titular de la Universidad del Centro de la Provincia de Buenos Aires y soy investigadora principal del Consejo Nacional de Ciencia y tecnología de la República Argentina (Conicet. OC: ¿Cuál es su área de investigación? MRO: Estoy adscrita en el área de psicología y educación. Dentro de esta área trabajo en didáctica de las ciencias. Dirijo un equipo dentro de la universidad que se dedica a esto y a formar profesores de matemáticas, física e informática y también dirijo el doctorado.

  12. 77 FR 46117 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2012-08-02

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-10823; 2200-1100-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington...

  13. 78 FR 11675 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-02-19

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-12080;2200-1100-665] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington...

  14. Thomas Young's contributions to geometrical optics.

    Science.gov (United States)

    Atchison, David A; Charman, W Neil

    2011-07-01

    In addition to his work on physical optics, Thomas Young (1773-1829) made several contributions to geometrical optics, most of which received little recognition in his time or since. We describe and assess some of these contributions: Young's construction (the basis for much of his geometric work), paraxial refraction equations, oblique astigmatism and field curvature, and gradient-index optics. © 2011 The Authors. Clinical and Experimental Optometry © 2011 Optometrists Association Australia.

  15. Thomas Hobbes: la resistencia política al Leviatán || Thomas Hobbes: Political Resistance To Leviathan

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Fernández Peychaux

    2013-12-01

    Full Text Available RESUMEN En el presente artículo se presentan cuatro claves de lectura de la obra de Thomas Hobbes desde las que fundamentar una noción de resistencia. Este aporte busca, en otras palabras, crear las condiciones de posibilidad de un debate filosófico ofuscado por el mito recurrente sobre el supuesto monstruo de Malmesbury. Una vez hecho esto, se propone delinear las bases de un enfoque metodológico que parta de dicha noción de resistencia. De ese modo, se fundamentaría el primer paso hacia una apropiación ?o expropiación? contemporánea de la matriz hobbesiana de la relación obediencia-seguridad   ABSTRACT This article presents four key of readings about Thomas Hobbes's work, from which it supports a particular notion of resistance. In others words, this contribution searches to create the conditions of posibility for a philosophical debate obfuscated by the recurrent myth about the monster of Malmesbury. Once done that, I offer setting the bases of a metodological aproach which stars from this notion of resistance. Thus, I would back the first step towards a contemporary appropriation ?or expropriation? of the obedience-security relationship within the Hobbesian matrix.  

  16. Thomas Hobbes: la resistencia política al Leviatán || Thomas Hobbes: Political Resistance To Leviathan

    Directory of Open Access Journals (Sweden)

    Diego Alejandro Fernández Peychaux

    2013-12-01

    Full Text Available RESUMEN En el presente artículo se presentan cuatro claves de lectura de la obra de Thomas Hobbes desde las que fundamentar una noción de resistencia. Este aporte busca, en otras palabras, crear las condiciones de posibilidad de un debate filosófico ofuscado por el mito recurrente sobre el supuesto monstruo de Malmesbury. Una vez hecho esto, se propone delinear las bases de un enfoque metodológico que parta de dicha noción de resistencia. De ese modo, se fundamentaría el primer paso hacia una apropiación ?o expropiación? contemporánea de la matriz hobbesiana de la relación obediencia-seguridad   ABSTRACT This article presents four key of readings about Thomas Hobbes's work, from which it supports a particular notion of resistance. In others words, this contribution searches to create the conditions of posibility for a philosophical debate obfuscated by the recurrent myth about the monster of Malmesbury. Once done that, I offer setting the bases of a metodological aproach which stars from this notion of resistance. Thus, I would back the first step towards a contemporary appropriation ?or expropriation? of the obedience-security relationship within the Hobbesian matrix.

  17. Thomas Mofolo: the man, the writer and his contexts

    African Journals Online (AJOL)

    higher studies through the Protestant PEMS Mission, Thomas grabbed this ... main centres of power in the greater Caledon River valley after 1828, and many ..... Other Christians, such as Anna 'Mantsopa Makhetha, continued faithfully to carry.

  18. 78 FR 45958 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-07-30

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-13406; PPWOCRADN0-PCU00RP14.R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke...

  19. 78 FR 59963 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-09-30

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-13770; PPWOCRADN0-PCU00RP14.R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of..., Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum, University of...

  20. 78 FR 44595 - Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of...

    Science.gov (United States)

    2013-07-24

    ... DEPARTMENT OF THE INTERIOR National Park Service [NPS-WASO-NAGPRA-13407; PPWOCRADN0-PCU00RP14.R50000] Notice of Inventory Completion: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke...

  1. A relativistic extended Fermi-Thomas-like equation for a self-gravitating system of fermions

    International Nuclear Information System (INIS)

    Merloni, A.; Ruffini, R.; Torroni, V.

    1998-01-01

    The authors extend previous results of a Fermi-Thomas model, describing self-gravitating fermions in their ground state, to a relativistic gravitational theory in Minkowski space. In such a theory the source term of the gravitational potential depends both on the pressure and the density of the fluid. It is shown that, in correspondence of this relativistic treatment, still a Fermi-Thomas-like equation can be derived for the self-gravitating system, though the non-linearities are much more complex. No Fermi-Thomas-like equation can be obtained in the General Relativistic treatment. The canonical results for neutron stars and white dwarfs are recovered and also some erroneous statements in the scientific literature are corrected

  2. Kriegs- und Generationszeugen: Adrienne Thomas und Vera Brittain // Generation and War Witnesses: Adrienne Thomas and Vera Brittain

    OpenAIRE

    Zitzlsperger, Ulrike

    2016-01-01

    Im Vordergrund stehen in diesem Beitrag Autorinnen, die sich in den dreißiger Jahren kritisch mit dem Ersten Weltkrieg und seinen Folgen auseinandersetzten. Am Beispiel von Adrienne Thomas ("Die Katrin wird Soldat") und Vera Brittain ("Testament of Youth") soll untersucht werden, wie die erklärte Zugehörigkeit von Frauen zur 'Lost Generation' mit der aktiven Kriegsteilnahme als Krankenschwester und einem differenzierten Patriotismusverständnis verbunden wurde. Auffallend sind dabei nicht nur ...

  3. Physical data from CTD casts in the North Pacific Ocean from the THOMAS G. THOMPSON and the THOMAS WASHINGTON in support of the Marathon 2 Project from 05 May 1985 to 07 September 1987 (NODC Accession 9400131)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Temperature and salinity profiles were collected from CTD casts in the North Pacific Ocean from the THOMAS G. THOMPSON and the THOMAS WASHINGTON. Data were collected...

  4. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita

    OpenAIRE

    Lohrenz, Steven E.; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-01-01

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS A...

  5. Thomas Graham: I. Contributions to thermodynamics, chemistry, and the occlusion of gases

    OpenAIRE

    Wisniak, Jaime

    2013-01-01

    Thomas Graham (1805-1869) is known as the founder of colloidal chemistry and for his fundamental research on the nature of phosphoric acid and phosphates, diffusion of gases, liquids, and solutions, adsorption of gases by metals, dialysis, osmosis, mass transfer through membranes, and the constitution of matter. A Thomas Graham (1805-1869) se le conoce como el fundador de la química coloidal y por sus investigaciones fundamentales en las áreas de la naturaleza del ácido fosfórico y los fos...

  6. Rita Pawlowski (Hg.: „Unsere Frauen stehen ihren Mann“. Berlin: trafo Wissenschaftsverlag 2008

    Directory of Open Access Journals (Sweden)

    Susanne Freund

    2009-07-01

    Full Text Available Rita Pawlowski stellt in diesem Band in alphabethischer Ordnung insgesamt 651 Frauen vor, die Abgeordnete der Volkskammer der DDR waren. Nach einer knappen Einführung zur Wahlhäufigkeit weiblicher Abgeordneter, zum Frauenanteil in der Volkskammer und in den Ausschüssen geben die Biographen im Wesentlichen Auskunft über die soziale Herkunft, die Parteizugehörigkeit, die schulische und berufliche Ausbildung und die Berufstätigkeit der einzelnen Frauen. Ziel dieses Bandes ist die Dokumentation des außergewöhnlichen Engagements von Frauen in der DDR, neben Berufstätigkeit und Familienpflichten politische Einflussmöglichkeiten zu nutzen. Damit wird ein Teilaspekt der Lebensgeschichte dieser Frauen beleuchtet, der – wie die Autorin im Vorfeld einräumt – keinen Anspruch auf Vollständigkeit erhebt. Dieser Hinweis ist wichtig, um dieses lexikalische Nachschlagewerk sinnvoll zu handhaben.In this volume, Rita Pawlowski alphabetically introduces a total of 651 women who were representatives of the People’s Chamber of the GDR. Following a short introduction to the election frequency of female representatives and to the number of women in the People’s Chamber and its committees, the biographies provide information on the social origin, party membership, educational and occupational training, and professional life of the individual women. The volume’s goal is to document these women’s extraordinary engagement in the GDR, for they not only held careers and fulfilled family duties, but also pursued possibilities for making political impact. The authors note at the outset that the book does not claim to be comprehensive, for it illuminates merely one aspect of the life stories of these women. This remark is important for making the reference work manageable.

  7. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu

    Directory of Open Access Journals (Sweden)

    Luan Jinwei

    2016-06-01

    Full Text Available Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA-enhancing X-ray susceptibility in FaDu cells.

  8. Thomas Linacre at the University of Padua.

    Science.gov (United States)

    Porzionato, Andrea; Macchi, Veronica; De Caro, Raffaele

    2010-11-01

    The Bo (meaning 'ox' in the Venetian dialect) is the historic seat of the University of Padua, founded in 1222. A full-length portrait of Thomas Linacre stands in its prestigious Sala dei Quaranta (Hall of the Forty), so called because of the portraits of forty great foreign scholars of the University, painted by Giacomo dal Forno in 1942. Thomas Linacre came to Italy in 1485, following an embassy by Henry VII to the Vatican. Linacre visited Bologna, Florence, Rome, Venice, Vicenza and Padua, where he took his degree in medicine in 1496 with great distinction. During his stay in Italy he met illustrious humanists and physicians, including Poliziano, Hermolaus Barbarus and Aldus Manutius Romanus, and Nicolaus Leonicenus who further stimulated him to the translation of classic works by Hippocrates and Galen. In 1518 Linacre played a pivotal role in the foundation of the Royal College of Physicians in London which, as first President, he organized on the basis of Italian models. With his portrait, the University of Padua celebrates the life and work of an astonishing figure linking the Italian and English medical cultures.

  9. First record of Histiotus laephotis Thomas (Chiroptera, Vespertilionidae from Brazil Primeiro registro de Histiotus laephotis Thomas (Chiroptera, Vespertilionidae no Brasil

    Directory of Open Access Journals (Sweden)

    João M. D. Miranda

    2007-12-01

    Full Text Available The first record of Histiotus laephotis Thomas, 1916 from Brazil is reported here. An adult male was caught with a mist net in a barn located within an Araucaria pine forest in the municipality of Passos Maia, State of Santa Catarina, Southern Brazil (26º46'48"S and 52º03'34"W. This record extends the distribution of this species in South America. Morphological and taxonomic notes of this species are described as well.O primeiro registro de Histiotus laephotis Thomas, 1916 o Brasil é aqui reportado. Um macho adulto foi coletado com rede de neblina (em abrigo artificial nos domínios da Floresta com Araucária, no Município de Passos Maia, Estado de Santa Catarina, Sul do Brasil (26º46'48"S e 52º03'34"W. Este registro amplia a distribuição da própria espécie na América do Sul. Aspectos morfológicos e taxonômicos desta espécie são também descritos.

  10. The Sovereign as Educator: Thomas Hobbes's National Curriculum.

    Science.gov (United States)

    Parry, Geraint

    1998-01-01

    Focuses on Thomas Hobbes, an English political philosopher who argued that the solution to civil disorders lay in a sovereign authority backed with force. Argues that education should be seen at the center of Hobbes's project of rescuing society from the disorders threatening civilization throughout 17th-century Europe. (CMK)

  11. Potential motion for Thomas-Fermi non-topological solitons

    International Nuclear Information System (INIS)

    Bahcall, S.

    1992-04-01

    In the Thomas-Fermi approximation to theories of coupled fermions and scalars, the equations for spherically-symmetric non-topological solitons have the form of potential motion. This gives a straightforward method for proving the existence of non-topological solitons in a given theory and for finding the constant-density, saturating solutions

  12. Rita Temmerman. Towards New Ways of Terminology Description: The Sociocognitive Approach

    Directory of Open Access Journals (Sweden)

    Rosemarie Gläser

    2011-10-01

    Full Text Available This book appeared as Volume 3 in the Series Terminology and Lexicography Research and Practice edited by Helmi Sonneveld and Sue-Ellen Wright. The author, Rita Temmerman, presently working at the Erasmus Hogeschool, Brussels and specialising in problems of terminology in various domains of the life sciences, presents a polemical, stimulating and innovative monograph which continues and deepens her previous research work. Her doctoral dissertation (Louvain 1998 focused on Terminology Beyond Standardisation: Language and Categorisation in the Life Sciences. The aim of the book under review, Towards New Ways of Terminology Description: The Sociocognitive Approach, is to elaborate a new theory, method and application of terminology research which seeks to overcome the obvious limitations of traditional terminology as chiefly represented by the Vienna School (Eugen W?ster, Helmut Felber, Infoterm and associated institutions.

  13. Mon Amour, de Thomas Ferrand

    OpenAIRE

    Châtelet, Caroline

    2018-01-01

    Dans l’un de ses précédents spectacles, Extase de Sainte Machine, Thomas Ferrand mettait en scène deux comédiens dans un espace nu. Debout avec à leurs pieds un pack de bières, ceux-ci ne bougeaient pas, ne parlaient pas, seule l’intensité lumineuse et la musique amenant le mouvement. Proposition radicale par son atmosphère dérivant du contemplatif à l’hypnotisme, Extase de Sainte-Machine frôlait, aussi, une forme d’hermétisme. Comme si à vouloir travailler sur des états statiques, sur le mot...

  14. Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas

    Directory of Open Access Journals (Sweden)

    Thereza de Almeida Garbelotto

    2011-09-01

    Full Text Available Contributions to the knowledge of Banasa Stål (Hemiptera, Heteroptera, Pentatomidae: Banasa chaca Thomas. The male of Banasa chaca Thomas is described with emphasis on external and internal genitalia and the female internal genitalia is described. Banasa chaca is newly recorded from Buenos Aires Province (Argentina.

  15. Monitoring Inland Storm Surge and Flooding from Hurricane Rita

    Science.gov (United States)

    McGee, Benton D.; Tollett, Roland W.; Mason, Jr., Robert R.

    2006-01-01

    Pressure transducers (sensors) and high-water marks were used to document the inland water levels related to storm surge generated by Hurricane Rita in southwestern Louisiana and southeastern Texas. On September 22-23, 2005, an experimental monitoring network of sensors was deployed at 33 sites over an area of about 4,000 square miles to record the timing, extent, and magnitude of inland hurricane storm surge and coastal flooding. Sensors were programmed to record date and time, temperature, and barometric or water pressure. Water pressure was corrected for changes in barometric pressure and salinity. Elevation surveys using global-positioning systems and differential levels were used to relate all storm-surge water-level data, reference marks, benchmarks, sensor measuring points, and high-water marks to the North American Vertical Datum of 1988 (NAVD 88). The resulting data indicated that storm-surge water levels over 14 feet above NAVD 88 occurred at three locations, and rates of water-level rise greater than 5 feet per hour occurred at three locations near the Louisiana coast.

  16. Os Episódios de Rita Patrício

    Directory of Open Access Journals (Sweden)

    Gustavo Rubim

    2014-12-01

    O texto propõe uma leitura do livro Episódios: da teorização estética em Fernando Pessoa, da au­toria de Rita Patrício. Datado de 2012, o livro só ficou realmente pronto e publicado em 2014. A leitura de­fende a originalidade deste exame minucioso dos textos de teoria estética e literária de Fernando Pessoa, tanto pela maneira como os trata autonomamente da obra poética e os estuda na sua escrita específica, quanto pelo efeito de deslocação dos tópicos habituais na análise do programa modernista português. A crí­tica do idealismo pessoano e da noção de obra enquanto totalidade or­gânica são sublinhados enquanto gestos condutores de toda a pesquisa. Propõem-se articulações com outros ensaios recentes que em Portugal procedem à revisão da crítica e da hermenêutica pes­soana.

  17. RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats.

    Science.gov (United States)

    Nolte, Thomas; Rittinghausen, Susanne; Kellner, Rupert; Karbe, Eberhard; Kittel, Birgit; Rinke, Matthias; Deschl, Ulrich

    2011-11-01

    Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of possible influence on the spontaneous incidence of Leydig cell tumors. In the 7453 male rats available for analysis, only one case of a Leydig cell carcinoma was identified. The incidence of Leydig cell adenomas differed markedly between strains. High incidences of close to 100% have been found in F344 rats, while the mean incidence was 4.2% in Sprague-Dawley rats and 13.7% in Wistar rats. Incidences in Wistar rats were highly variable, primarily caused by different sources of animals. Mean incidences per breeder varied from 2.8 to 39.9%. Analyses for the dependency on further parameters have been performed in Wistar rats. In breeders G and I, the Leydig cell tumor incidence decreased over the observation period and with increasing mean terminal body weight. The incidence of Leydig cell tumors increased with mean age at necropsy and was higher in studies with dietary admixture compared to gavage studies. These parameters had no effect on Leydig cell tumor incidence in breeders A and B. Animals from almost all breeders had a considerably higher mean age at necropsy when bearing a Leydig cell adenoma than animals without a Leydig cell adenoma. Studies with longitudinal trimming of the testes had a higher incidence than studies with transverse trimming. The observed dependencies and breeder differences are discussed and explanations are given. Consequences for the use of historical control data are outlined. With the retrospective analyses presented here we were able to confirm the published features of Leydig cell adenomas and carcinomas. This indicates that the RITA database is a valuable tool for analyses of tumors for their biological features. Furthermore, it demonstrates that the RITA database is highly beneficial for

  18. Multi-proxy Characterization of Two Recent Storm Deposits Attributed to Hurricanes Rita and Ike in the Chenier Plain of Southwestern Louisiana

    Science.gov (United States)

    Yao, Q.; Liu, K. B.; Ryu, J.

    2017-12-01

    The Chenier Plain in southwestern Louisiana owes its origin to dynamic depositional processes that are dominated by delta-switching of the Mississippi River to the east, while frequent hurricane activities also play an important role in its geomorphology and sedimentary history. However, despite several studies in the literature, the sediment-stratigraphic characteristics of recent or historic hurricane deposits are still not well documented from the Chenier Plain. In 2005 and 2008, Hurricane Rita (category 3) and Ike (category 2) made landfall on the coasts of Louisiana and Texas. Remote sensing images confirm that the Rockefeller Wildlife Refuge, located at the east end of the Louisiana Chenier Plain, was heavily impacted by both hurricanes. We analyzed the lithology and chemical stratigraphy of three 30 cm sediment monoliths (ROC-1, ROC-2, and ROC-3) recovered from a coastal saltmarsh in the Rockefeller Wildlife Refuge to identify the event deposits attributed to these two storms. Each monolith contains 2 distinct light-colored clastic sediment layers imbedded in brown organic clay. The loss-on-ignition and X-ray fluorescence results show that the hurricane layers have increased contents of Ca, Sr, Zr, and carbonates and decreased contents of water and organics. Surprisingly, despite its greater intensity and more severe impacts, Hurricane Rita left a much thinner storm deposit than did Hurricane Ike in all monoliths. Satellite data reveal that Hurricane Rita caused significant coastal erosion and shoreline recession, rendering the sampling sites much closer to the beach and ocean and therefore more prone to storm surges and overwash deposition than when Hurricane Ike struck three years later. Our results suggest that site-to-sea distance, which affects a study site's paleotempestological sensitivity, can play a bigger role in affecting the thicknesses of storm deposits than the intensity of the hurricane.

  19. Information entropy and Thomas-Fermi screening functions

    International Nuclear Information System (INIS)

    Donnamaria, M.C.; Meson, A.M.; Proto, A.N.

    1989-11-01

    In this work we apply the information entropy concept to analyze different trial electron densities in momentum and coordinate spaces, into the Thomas-Fermi density functional formalism. Furthermore, we try to assess how well-known physical properties of neutral atoms are reproduced and hence evaluate the quality of the screening functions in the light of their predictive capacity. (author). 32 refs, 4 figs, 3 tabs

  20. Towards silence: Thomas Mofolo, small literatures and poor translation

    African Journals Online (AJOL)

    Despite having written three novels in the first decade of the 20th century, Thomas Mofolo has been largely ignored by historians .... poems dealing directly with the stars, the moon, and the Milky Way. In other ..... Mzilikazi is leading the flight:.

  1. Thomas-Fermi treatment of nuclear masses, deformations and density distributions

    International Nuclear Information System (INIS)

    Myers, W.D.; Swiatecki, W.J.

    1994-08-01

    A recently completed Thomas-Fermi model of nuclei is described. Six adjustable parameters of the effective nucleon-nucleon interaction were fitted to the shell-corrected binding energies of 1654 nuclei and to the diffuseness of the nuclear surface. The model is then successful in reproducing nuclear sizes, and only small deviations are found between calculated and measured fission barriers of 36 nuclei. The model is applied to the prediction of fission barriers of light elements, to drip-line nuclei like 82 Sn and 170 Sn, to the properties of nuclear and neutron matter and to nuclear bubble configurations with Z 2 /A ∼ 100. The relation of a Thomas-Fermi theory to the Droplet and Liquid Drop models is illustrated

  2. Thomas Mann e a cena intelectual no Brasil: encontros e desencontros

    Directory of Open Access Journals (Sweden)

    Sibele Paulino

    2009-12-01

    Full Text Available A origem brasileira de Thomas Mann, por parte de sua mãe, Julia da Silva Bruhns, deu ocasião, na maturidade do escritor, a seu contato com intelectuais brasileiros ou estrangeiros ligados à cena cultural do Brasil. No primeiro grupo, tem-se Gilberto Freyre, Sérgio Buarque de Holanda e Erico Verissimo. Residentes no Brasil, Karl Lustig-Prean, que posteriormente retornará à Europa, e o tradutor Herbert Caro, que se radica em definitivo no Brasil. Também o contato direto ou indireto com pensadores e escritores como Karl Loewenstein, Heinrich Eduard Jacob, Marte Brill e Stefan Zweig colaboraram para a aproximação de Thomas Mann ao universo brasileiro. Estes e outros pontos de contato são descritos no presente artigo, que pretende difundir dados e documentos há muito inacessíveis ou inéditos, no sentido de contribuir com abordagens atualizadas da obra de Thomas Mann e oferecer à pesquisa especializada a indicação de dados biográficos e documentais relacionados ao escritor, no que concerne à sua relação com o Brasil.

  3. 76 FR 58031 - Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum...

    Science.gov (United States)

    2011-09-19

    ... DEPARTMENT OF THE INTERIOR National Park Service [2253-665] Notice of Intent To Repatriate Cultural Items: Thomas Burke Memorial Washington State Museum, University of Washington, Seattle, WA AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Thomas Burke Memorial Washington State Museum...

  4. Ethical Implications of Thomas Reid's Philosophy of Rhetoric.

    Science.gov (United States)

    Skopec, Eric Wm.

    Eighteenth century Scottish philosopher Thomas Reid's emphasis on first principles of knowledge is fundamental to his ethics of rhetoric. Reid found the reduction of mental activities to material phenomena by Hobbes and others to be particularly odious and destructive of common sense. Turning to the analysis of human nature, he developed a radical…

  5. Thomas Carlyle and the Characteristics of Nineteenth-Century English Literature

    DEFF Research Database (Denmark)

    Schatz-Jakobsen, Claus

    2001-01-01

    Artiklen diskuterer den skotske forfatter Thomas Carlyles plads i den engelske litteraturs historie og argumenterer for at hans skrift, "Characteristics" (1831), selv dramatiserer og dekonstruerer litteraturhistoriske grænsedragninger....

  6. Thomas B. Greenfield: A Challenging Perspective of Organizations

    Science.gov (United States)

    Bailey, Scott

    2010-01-01

    Organizations are not real; people are. Any science or theory of organizations must consider how the organization impinges, in a very real and tangible way, on the lives of its members. This article traces the development of one such theoretical branch of organizational science through the pioneering work of Thomas B. Greenfield. The author uses…

  7. Santa Rita Experimental Range: 100 years (1903 to 2003) of accomplishments and contributions; conference proceedings; 2003 October 30-November 1; Tucson, AZ

    Science.gov (United States)

    Mitchel P. McClaran; Peter F. Ffolliott; Carleton B. Edminster

    2003-01-01

    The purpose of this conference was to celebrate the 100 years of accomplishments and contributions of the Santa Rita Experimental Range, the longest continuously operating research area dedicated to the sustainable management of North American rangelands. The conference consisted of one-and-a-half days of invited synthesis papers and contributed poster presentations...

  8. O Estado cristão em Thomas Hobbes

    Directory of Open Access Journals (Sweden)

    Daniel Artur Emidio Branco

    2016-12-01

    Full Text Available O presente artigo tem como finalidade a investigação do pensamento do filósofo inglês Thomas Hobbes (1588-1679, mais precisamente a relação entre Igreja e Estado, valendo-se de suas obras, em especial Leviatã (1651. Com o título O Estado Eclesiástico em Thomas Hobbes, o artigo busca mostrar como as conclusões de Hobbes acerca do papel da Igreja no Estado são relevantes para o século XXI. A concepção de Evangelho de Cristo como um reino de outro mundo, a natureza privada da fé, o pontificado do soberano como aquele que se posiciona está entre Deus e os homens, a união entre Lei Mosaica e Lei Natural e a união entre Igreja e Estado são os delimitadores do grande tema, que busca levar o leitor contemporâneo ao conhecimento das conclusões de Hobbes e, assim, considerar a aplicação das mesmas a sua geração.

  9. The convenient myth of Thomas Szasz.

    Science.gov (United States)

    Buchanan-Barker, P; Barker, P

    2009-02-01

    Thomas Szasz's original critique of the concept of 'mental illness' is almost 50 years old. Over that half century Szasz has maintained a consistent campaign against the 'Therapeutic State', challenging the paternalism of coercive psychiatry and defending liberty and autonomy. Despite his widespread celebrity Szasz continues to be misread and misrepresented. In this paper we review some of Szasz's key ideas, in the light of Clarke's recent critique, setting this within the context of 'mental health nursing' and the problems in living affecting persons worldwide.

  10. St. Thomas and the Divine Origin of Law: Some Notes

    Directory of Open Access Journals (Sweden)

    Lawrence Dewan, O.P.

    2008-12-01

    Full Text Available This article presents a series of notes on the concept of Law and itsrelationship to God in Classical Antiquity, specifically taking into account the viewpoints of Aristotle and Saint Thomas Aquinas.

  11. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Lohrenz, Steven E; Cai, Wei-Jun; Chen, Xiaogang; Tuel, Merritt

    2008-07-10

    The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490) and chlorophyll (chlor_a) from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies) identified on the basis of sea surface height anomaly (SSHA). Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels off Texas and

  12. The modified Thomas test is not a valid measure of hip extension unless pelvic tilt is controlled

    Directory of Open Access Journals (Sweden)

    Andrew D. Vigotsky

    2016-08-01

    Full Text Available The modified Thomas test was developed to assess the presence of hip flexion contracture and to measure hip extensibility. Despite its widespread use, to the authors’ knowledge, its criterion reference validity has not yet been investigated. The purpose of this study was to assess the criterion reference validity of the modified Thomas test for measuring peak hip extension angle and hip extension deficits, as defined by the hip not being able to extend to 0º, or neutral. Twenty-nine healthy college students (age = 22.00 ± 3.80 years; height = 1.71 ± 0.09 m; body mass = 70.00 ± 15.60 kg were recruited for this study. Bland–Altman plots revealed poor validity for the modified Thomas test’s ability to measure hip extension, which could not be explained by differences in hip flexion ability alone. The modified Thomas test displayed a sensitivity of 31.82% (95% CI [13.86–54.87] and a specificity of 57.14% (95% CI [18.41–90.10] for testing hip extension deficits. It appears, however, that by controlling pelvic tilt, much of this variance can be accounted for (r = 0.98. When pelvic tilt is not controlled, the modified Thomas test displays poor criterion reference validity and, as per previous studies, poor reliability. However, when pelvic tilt is controlled, the modified Thomas test appears to be a valid test for evaluating peak hip extension angle.

  13. Peakonsul Jaanus Kirikmäe andis teenetemärgi praost Thomas Vagale / Airi Vaga ; foto: Harold Karu

    Index Scriptorium Estoniae

    Vaga, Airi, 1940-

    2008-01-01

    President Toomas Hendrik Ilves annetas iseseisvuspäeva puhul USA I praostkonna praostile Thomas Vagale Valgetähe IV klassi teenetemärgi. Teenetemärgi andis Thomas Vagale üle Eesti Vabariigi peakonsul Jaanus Kirikmäe

  14. Reflective Teaching and Practice: Interview with Thomas Farrell

    Science.gov (United States)

    Pang, Alvin

    2017-01-01

    Thomas Farrell is widely known for his views and publications on the topic of Reflective Practice, which is key to the professional development of teachers in 21st century classrooms. He is Professor of Applied Linguistics at Brock University, Canada. Farrell has been a language teacher and teacher educator since 1978 and has worked in Korea,…

  15. The Weyl non-Abelian gauge field and the Thomas precession

    International Nuclear Information System (INIS)

    Barbashov, B.M.; Pestov, A.B.

    1998-01-01

    The connection between the Fermi-Walker transport and the Weyl non-Abelian gauge field is established. A theoretical possibility of detecting the Weyl gauge field caused by the Thomas precession of a gyroscope is discussed

  16. Hurricanes Katrina and Rita: Temporary Emergency Impact Aid Provided Education Support for Displaced Students. Report to the Congressional Requesters. GAO-11-839

    Science.gov (United States)

    Scott, George A.

    2011-01-01

    In August and September 2005, Hurricanes Katrina and Rita devastated large portions of the U.S. Gulf Coast, resulting in nearly 2,000 deaths and severe damage to 305,000 houses and apartments. Thousands of families relocated to communities throughout the United States and enrolled their children in local public or private schools. Some families…

  17. Thomas Young's research on fluid transients: 200 years on

    NARCIS (Netherlands)

    Tijsseling, A.S.; Anderson, A.; Hunt, S.

    2008-01-01

    Thomas Young published in 1808 his famous paper (1) in which he derived the pressure wave speed in an incompressible liquid contained in an elastic tube. Unfortunately, Young's analysis was obscure and the wave speed was not explicitly formulated, so his achievement passed unnoticed until it was

  18. Thomas Young's research on fluid transients : 200 years on

    NARCIS (Netherlands)

    Tijsseling, A.S.; Anderson, A.

    2008-01-01

    Thomas Young published in 1808 his famous paper (1) in which he derived the pressure wave speed in an incompressible liquid contained in an elastic tube. Unfortunately, Young's analysis was obscure and the wave speed was not explicitly formulated, so his achievement passed unnoticed until it was

  19. 33 CFR 207.425 - Calumet River, Ill.; Thomas J. O'Brien Lock and Controlling Works and the use, administration and...

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Calumet River, Ill.; Thomas J. O... DEFENSE NAVIGATION REGULATIONS § 207.425 Calumet River, Ill.; Thomas J. O'Brien Lock and Controlling Works... paragraph (a)(1) of this section. (b) Lock—(1) Operation. The Thomas J. O'Brien Lock and Dam is part of the...

  20. St. Thomas and the hilemorfic ontology

    Directory of Open Access Journals (Sweden)

    Lawrence Dewan, O.P.

    2009-06-01

    Full Text Available This article presents the relevancy of Aristotle’s hylemorphic ontology.Aristotle himself highlighted the importance and astonishing complexityof the problem of prime matter’s ontological status and he presenting thesolution in his doctrine of hylemorphism. As Saint Thomas Aquinasnoted, it is a crucial issue for philosophy because all four, hilemorfism,logic, physics and metaphysics, stand or fall depending on a correctunderstanding of the ontology of prime matter and of the kind of causalrelationship which exist between prime matter and substantial form ingenerable and corruptible substance.

  1. Pilgrim Souvenir: Ampulla of Thomas Becket

    OpenAIRE

    Amy Jeffs

    2017-01-01

    This tin ampulla was probably purchased by a pilgrim near the shrine of St Thomas Becket in Canterbury. It is designed to contain holy water and be hung around the neck on a cord. Measuring 100 by 87 millimetres, it is in the form of a narrow, pointed vessel surrounded by an openwork penannular frame and would have been rapidly slush-cast, in one go, in a three-part mould. A date in the first half of the thirteenth century is probable based on the style of the military figures’ armour and the...

  2. Localized Donaldson-Thomas theory of surfaces

    DEFF Research Database (Denmark)

    Gholampour, Amin; Sheshmani, Artan; Yau, Shing-Tung

    2017-01-01

    Let S be a projective simply connected complex surface and  be a line bundle on S. We study the moduli space of stable compactly supported 2-dimensional sheaves on the total spaces of . The moduli space admits a ℂ∗-action induced by scaling the fibers of . We identify certain components of the......  is the canonical bundle of S, the Vafa-Witten invariants defined recently by Tanaka-Thomas, can be extracted from these localized DT invariants. VW invariants are expected to have modular properties as predicted by S-duality....

  3. The Antiaircraft Journal. Volume 93, Number 6, November-December 1950

    Science.gov (United States)

    1950-12-01

    compromise. Russia and the satellites deposited a reser- vation against freeing the original Detaining Power from responsibility. HUl\\ IANE TREATMENT OF...H., 543 Flynn Ave., Redwood City, Calif. Cox, Thomas R., 46 Maitland Rd., Stamford, Conn. DeRita, Joseph, Box 83, Lafayette, R. I. DiEnno, John, Jr... Ian 2-40 Broudy, Harold, Capt. 2- 2 Cunningham, Elmo E., 1st Lt. 5- 7 Currie, A. A., Lt. Col. 1-26 Dillon, Joseph V., Brig. Gen 6-34 Dineley, R. L., M

  4. Nonlinear terms in storm surge predictions: Effect of tide and shelf geometry with case study from Hurricane Rita

    Science.gov (United States)

    Rego, JoãO. L.; Li, Chunyan

    2010-06-01

    This study applied the finite volume coastal ocean model (FVCOM) to the storm surge induced by Hurricane Rita along the Louisiana-Texas coast. The model was calibrated for tides and validated with observed water levels. Peak water levels were shown to be lower than expected for a landfall at high tide. For low- and high-tide landfalls, nonlinear effects due to tide-surge coupling were constructive and destructive to total storm tide, respectively, and their magnitude reached up to 70% of the tidal amplitude in the Rita application. Tide-surge interaction was further examined using a standard hurricane under idealized scenarios to evaluate the effects of various shelf geometries, tides, and landfall timings (relative to tide). Nonlinearity was important between landfall position and locations within 2.5 × radius of maximum winds. On an idealized wide continental shelf, nonlinear effects reached up to 80% of the tidal amplitude with an S2 tide and up to 47% with a K1 tide. Increasing average depths by 4 m reduced nonlinear effects to 41% of the tidal amplitude; increasing the slope by a factor of 3 produced nonlinearities of just 26% of tide (both with a K1 tide). The nonlinear effect was greatest for landfalls at low tide, followed by landfalls at high tide and then by landfalls at midebb or midflood.

  5. Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA.

    Science.gov (United States)

    Jones, Richard J; Bjorklund, Chad C; Baladandayuthapani, Veerabhadran; Kuhn, Deborah J; Orlowski, Robert Z

    2012-10-01

    The human double minute (HDM)-2 E3 ubiquitin ligase plays a key role in p53 turnover and has been validated preclinically as a target in multiple myeloma (MM) and mantle cell lymphoma (MCL). HDM-2 inhibitors are entering clinical trials, and we therefore sought to understand potential mechanisms of resistance in lymphoid models. Wild-type p53 H929 MM and Granta-519 MCL cells resistant to MI-63 or Nutlin were generated by exposing them to increasing drug concentrations. MI-63-resistant H929 and Granta-519 cells were resistant to Nutlin, whereas Nutlin-resistant cells displayed cross-resistance to MI-63. These cells also showed cross-resistance to bortezomib, doxorubicin, cisplatin, and melphalan, but remained sensitive to the small molecule inhibitor RITA (reactivation of p53 and induction of tumor cell apoptosis). HDM-2 inhibitor-resistant cells harbored increased p53 levels, but neither genotoxic nor nongenotoxic approaches to activate p53 induced HDM-2 or p21. Resequencing revealed wild-type HDM-2, but mutations were found in the p53 DNA binding and dimerization domains. In resistant cells, RITA induced a G(2)-M arrest, upregulation of p53 targets HDM-2, PUMA, and NOXA, and PARP cleavage. Combination regimens with RITA and MI-63 resulted in enhanced cell death compared with RITA alone. These findings support the possibility that p53 mutation could be a primary mechanism of acquired resistance to HDM-2 inhibitors in MCL and MM. Furthermore, they suggest that simultaneous restoration of p53 function and HDM-2 inhibition is a rational strategy for clinical translation.

  6. The burden of rare cancers in Italy: the surveillance of rare cancers in Italy (RITA) project.

    Science.gov (United States)

    Trama, Annalisa; Mallone, Sandra; Ferretti, Stefano; Meduri, Francesca; Capocaccia, Riccardo; Gatta, Gemma

    2012-01-01

    The project Surveillance of rare cancers in Italy (RITA) provides, for the first time, estimates of the burden of rare cancers in Italy based on the list of rare cancers proposed in collaboration with the European project Surveillance of Rare Cancers in Europe (RARECARE). RITA analyzed data from Italian population-based cancer registries (CR). The period of diagnosis was 1988 to 2002, and vital status information was available up to December 31, 2003. Incidence rates were estimated for the period 1995-2002, survival for the years 2000-2002 (with the period method of Brenner), and complete prevalence at January 1, 2003. Rare cancers are those with an incidence <6/100,000/year. In Italy, every year there are 60,000 new diagnoses of rare cancers corresponding to 15% of all new cancer diagnoses. Five-year relative survival was on the average worse for rare cancers (53%) than for common cancers (73%). A total of 770,000 patients were living in Italy in 2008 with a diagnosis of a rare cancer, 22% of the total cancer prevalence. Our estimates constitute a useful base for further research and support the idea that rare cancers are a public health problem that deserves attention. Centers of expertise for rare cancers that pool cases, expertise and resources could ensure an adequate clinical management for these diseases. Our data also showed that cancer registries are suitable sources of data to estimate incidence, prevalence and survival for rare cancers and should continue to monitoring rare cancers in Italy.

  7. Semiclassical approach to Regge poles trajectories calculations for nonsingular potentials: Thomas-Fermi type

    International Nuclear Information System (INIS)

    Belov, S M; Avdonina, N B; Felfli, Z; Marletta, M; Msezane, A Z; Naboko, S N

    2004-01-01

    A simple semiclassical approach, based on the investigation of anti-Stokes line topology, is presented for calculating Regge poles for nonsingular (Thomas-Fermi type) potentials, namely potentials with singularities at the origin weaker than order -2. The anti-Stokes lines for Thomas-Fermi potentials have a more complicated structure than those of singular potentials and require careful application of complex analysis. The explicit solution of the Bohr-Sommerfeld quantization condition is used to obtain approximate Regge poles. We introduce and employ three hypotheses to obtain several terms of the Regge pole approximation

  8. Questions and Answers for Ken Thomas' "Intra-Extra Vehicular Activity Russian and Gemini Spacesuits" Presentation

    Science.gov (United States)

    Thomas, Kenneth S.

    2016-01-01

    Kenneth Thomas will discuss the Intra-Extra Vehicular Activity Russian & Gemini spacesuits. While the United States and Russia adapted to existing launch- and reentry-type suits to allow the first human ventures into the vacuum of space, there were differences in execution and capabilities. Mr. Thomas will discuss the advantages and disadvantages of this approach compared to exclusively intravehicular or extra-vehicular suit systems.

  9. The Thomas-Reiche-Kuhn sum rule and the toroid moments

    International Nuclear Information System (INIS)

    Dubovik, V.M.

    1975-01-01

    By example of the Thomas-Reiche-Kuhn sum rule a procedure is given for calculating the retardation effects in any E-transition strengths via the toroid moments. The investigation has been performed at the Laboratory of Theoretical Physics, JINR

  10. 75 FR 58426 - Notice of Intent to Repatriate Cultural Items: Thomas Gilcrease Institute of American History and...

    Science.gov (United States)

    2010-09-24

    ...: Thomas Gilcrease Institute of American History and Art, Tulsa, OK AGENCY: National Park Service, Interior... Thomas Gilcrease Institute of American History and Art (Gilcrease Museum), Tulsa, OK, that meet the... the Gilcrease Museum for the preservation of North American history. The first bundle is made of...

  11. The Concurrentism of Thomas Aquinas: Divine Causation and Human Freedom

    Czech Academy of Sciences Publication Activity Database

    Dvořák, Petr

    2013-01-01

    Roč. 41, č. 3 (2013), s. 617-634 ISSN 0048-3893 R&D Projects: GA ČR(CZ) GAP401/11/0371 Institutional support: RVO:67985955 Keywords : divine causation * free will * concurrentism * Thomas Aquinas Subject RIV: AA - Philosophy ; Religion

  12. E.E.L.K. Peapiiskopi valimised / Thomas Vaga, Ivar Nippak

    Index Scriptorium Estoniae

    Vaga, Thomas, 1938-

    2007-01-01

    21. detsembril teatas häältelugemiskomisjon, et kaks enam hääli saanud kandidaati on Thomas Vaga ja Andres Taul. Samade kandidaatide vahel toimub korduv hääletus. Uued valimismaterjalid saadetakse välja 2007. aasta jaanuaris

  13. Some notes on time dependent Thomas Fermi approximation

    International Nuclear Information System (INIS)

    Holzwarth, G.

    1979-01-01

    The successful use of effective density-dependent potentials in static Hartree-Fock calculations for nuclear ground-state properties has led to the question whether it is possible to obtain significant further simplification by approximating also the kinetic energy part of the ground state energy by a functional of the local density alone. The great advantage of such an approach is that its complexity is independent of particle number; the size of the system enters only through parameters, Z and N. The simple 'extended Thomas Fermi' functionals are based on the assumption of a spherically symmetric local Fermi surface throughout the nucleus and they represent the 'liquid drop' part of the static total energy. Given this static formalism which is solved directly for the local density without considering individual particles one might ask for a possible dynamical extension in the same sense as TDHF is a dynamical extension of the static HF approach. The aim of such a Time Dependent Thomas Fermi (TDTF) approximation would be to determine directly the time-dependent local single-particle density from given initial conditions and the single-particle current density without following each particle on its individual orbit

  14. A new estimate of the Khirzhnits corrections to the zero temperature Thomas-Fermi equation-of-state

    International Nuclear Information System (INIS)

    Szichman, H.; Krumbein, A.D.; Eliezer, S.

    1984-09-01

    A method is proposed for estimating the zero temperature limit of the Khirzhnits corrections to the Thomas-Fermi equation-of-state by extrapolation of the finite-temperature results. The cold curves so obtained for Ti, Fe, Cu and Ta are compared with experimental results as well as with those calculated using other variations of the Thomas-Fermi model

  15. Homage to Rita Levi-Montalcini, the queen of modern neuroscience.

    Science.gov (United States)

    Aloe, Luigi; Chaldakov, George N

    2013-08-01

    The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi-Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth-stimulating factor, later studies revealed that non-neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the 'unpredictable' ideogenesis of the discovery of NGF, a eureka in the neuroscience. © 2013 International Federation for Cell Biology.

  16. Feynman versus Bakamjian-Thomas in light-front dynamics

    International Nuclear Information System (INIS)

    Araujo, W.R.B. de; Beyer, M.; Weber, H.J.; Frederico, T.

    1999-01-01

    We compare the Bakamjian-Thomas (BT) formulation of relativistic few-body systems with light-front field theories that maintain closer contact with Feynman diagrams. We find that Feynman diagrams distinguish Melosh rotations and other kinematical quantities belonging to various composite subsystem frames that correspond to different loop integrals. The BT formalism knows only the rest frame of the whole composite system, where everything is evaluated. (author)

  17. Thomas Aquinas: On Law, Tyranny and Resistance | Swartz | Acta ...

    African Journals Online (AJOL)

    Thomas Aquinas's notion on law, tyranny and resistance served as a limitation on governmental powers. When those who bear the law command things which exceed the competence of such authority, the subject is free to obey or disobey. The function of the law culminates in two maxims: quantum ad vim coactivam legis ...

  18. Dust acoustic solitary and shock excitations in a Thomas-Fermi magnetoplasma

    Energy Technology Data Exchange (ETDEWEB)

    Rahim, Z.; Qamar, A. [Institute of Physics and Electronics, University of Peshawar, Peshawar 25000 (Pakistan); National Center for Physics (NCP) at QAU Campus, Shahdra Valley Road, Islamabad 44000 (Pakistan); Ali, S. [National Center for Physics (NCP) at QAU Campus, Shahdra Valley Road, Islamabad 44000 (Pakistan)

    2014-07-15

    The linear and nonlinear properties of dust-acoustic waves are investigated in a collisionless Thomas-Fermi magnetoplasma, whose constituents are electrons, ions, and negatively charged dust particles. At dust time scale, the electron and ion number densities follow the Thomas-Fermi distribution, whereas the dust component is described by the classical fluid equations. A linear dispersion relation is analyzed to show that the wave frequencies associated with the upper and lower modes are enhanced with the variation of dust concentration. The effect of the latter is seen more strongly on the upper mode as compared to the lower mode. For nonlinear analysis, we obtain magnetized Korteweg-de Vries (KdV) and Zakharov-Kuznetsov (ZK) equations involving the dust-acoustic solitary waves in the framework of reductive perturbation technique. Furthermore, the shock wave excitations are also studied by allowing dissipation effects in the model, leading to the Korteweg-de Vries-Burgers (KdVB) and ZKB equations. The analysis reveals that the dust-acoustic solitary and shock excitations in a Thomas-Fermi plasma are strongly influenced by the plasma parameters, e.g., dust concentration, dust temperature, obliqueness, magnetic field strength, and dust fluid viscosity. The present results should be important for understanding the solitary and shock excitations in the environments of white dwarfs or supernova, where dust particles can exist.

  19. Dust acoustic solitary and shock excitations in a Thomas-Fermi magnetoplasma

    International Nuclear Information System (INIS)

    Rahim, Z.; Qamar, A.; Ali, S.

    2014-01-01

    The linear and nonlinear properties of dust-acoustic waves are investigated in a collisionless Thomas-Fermi magnetoplasma, whose constituents are electrons, ions, and negatively charged dust particles. At dust time scale, the electron and ion number densities follow the Thomas-Fermi distribution, whereas the dust component is described by the classical fluid equations. A linear dispersion relation is analyzed to show that the wave frequencies associated with the upper and lower modes are enhanced with the variation of dust concentration. The effect of the latter is seen more strongly on the upper mode as compared to the lower mode. For nonlinear analysis, we obtain magnetized Korteweg-de Vries (KdV) and Zakharov-Kuznetsov (ZK) equations involving the dust-acoustic solitary waves in the framework of reductive perturbation technique. Furthermore, the shock wave excitations are also studied by allowing dissipation effects in the model, leading to the Korteweg-de Vries-Burgers (KdVB) and ZKB equations. The analysis reveals that the dust-acoustic solitary and shock excitations in a Thomas-Fermi plasma are strongly influenced by the plasma parameters, e.g., dust concentration, dust temperature, obliqueness, magnetic field strength, and dust fluid viscosity. The present results should be important for understanding the solitary and shock excitations in the environments of white dwarfs or supernova, where dust particles can exist

  20. Individual and contextual variation in Thomas langur male loud calls

    NARCIS (Netherlands)

    Wich, S.A.; Koski, S.; Vries, Han de; Schaik, Carel P. van

    2003-01-01

    Individual and contextual differences in male loud calls of wild Thomas langurs (Presbytis thomasi) were studied in northern Sumatra, Indonesia. Loud calls were given in the following contexts: morning calls, vocal responses to other groups, between-group encounter calls and alarmcalls. Loud

  1. On the Symbolism of Thomas Mann

    Directory of Open Access Journals (Sweden)

    Vasily M. Tolmatchoff

    2017-09-01

    Full Text Available The essay discusses Thomas Mann’s symbolism and its parameters as well as Mann’s interpretation of the crisis of European spiritual values. Тhe author examines the role of Nietzsche in Mann’s heritage as well as interconnections between Mann and Wilde, Mann and Gide. Buddenbrooks is interpreted as a novel about the end of the German Renaissance; duality of the modern artist is shown on the example of “Tonio Kröger” while the paradoxes of his eroticism are analyzed on the example of “Der Tod in Venedig.”

  2. Limitations of the Porter-Thomas distribution

    Science.gov (United States)

    Weidenmüller, Hans A.

    2017-12-01

    Data on the distribution of reduced partial neutron widths and on the distribution of total gamma decay widths disagree with the Porter-Thomas distribution (PTD) for reduced partial widths or with predictions of the statistical model. We recall why the disagreement is important: The PTD is a direct consequence of the orthogonal invariance of the Gaussian Orthogonal Ensemble (GOE) of random matrices. The disagreement is reviewed. Two possible causes for violation of orthogonal invariance of the GOE are discussed, and their consequences explored. The disagreement of the distribution of total gamma decay widths with theoretical predictions cannot be blamed on the statistical model.

  3. Pilgrim Souvenir: Ampulla of Thomas Becket

    Directory of Open Access Journals (Sweden)

    Amy Jeffs

    2017-06-01

    Full Text Available This tin ampulla was probably purchased by a pilgrim near the shrine of St Thomas Becket in Canterbury. It is designed to contain holy water and be hung around the neck on a cord. Measuring 100 by 87 millimetres, it is in the form of a narrow, pointed vessel surrounded by an openwork penannular frame and would have been rapidly slush-cast, in one go, in a three-part mould. A date in the first half of the thirteenth century is probable based on the style of the military figures’ armour and the archaeological contexts of stylistically similar ampullae.

  4. The Thomas-Fermi model: momentum expectation values

    International Nuclear Information System (INIS)

    Dmitrieva, I.K.; Plindov, G.I.

    1983-01-01

    Within the Thomas-Fermi model including the exchange interaction and contributions of strongly bound electrons, analytical expressions are obtained for all momentum expectation values and for some of the expectation values of powers of the electron density for an atom with an arbitrary degree of ionization. It is shown that a correct treatment of strongly bound electrons gives a quantitative estimate of and within 3 - 1 expansion coefficients for and are given as an explicit function of the electron number

  5. Tartu ehk unbewusste Ängste / Rauno Thomas Moss ; interv. Harry Liivrand

    Index Scriptorium Estoniae

    Moss, Rauno Thomas, 1977-

    2008-01-01

    Rauno Thomas Mossi (1977) näitus "Silent Tartu aka Clinical" Vaal galeriis. Kunstniku eluloolisi andmeid, loomingust, alasti mehekeha kujutamisest. Töötab Tartu Ülikoolis joonistamise ja plastilise anatoomia õppejõuna. Tema lemmikkunstnikud

  6. Cold pasta phase in the extended Thomas-Fermi approximation

    Science.gov (United States)

    Avancini, S. S.; Bertolino, B. P.

    2015-10-01

    In this paper, we aim to obtain more accurate values for the transition density to the homogenous phase in the nuclear pasta that occurs in the inner crust of neutron stars. To that end, we use the nonlinear Walecka model at zero temperature and an approach based on the extended Thomas-Fermi (ETF) approximation.

  7. Thomas Hopley and Mid-Victorian Attitudes to Corporal Punishment

    Science.gov (United States)

    Middleton, Jacob

    2005-01-01

    This paper discusses the trial of Thomas Hopley, accused of killing his pupil Reginald Cancellor in 1860 during an act of corporal punishment. The case provoked immediate sensational interest and became an important defining point in how corporal punishment is treated in British law. Established by this trial was the test that any corporal…

  8. Waren Judas en Thomas gnostici? Het evangelie naar Johannes ...

    African Journals Online (AJOL)

    and Philip are also more conspicuous characters in the Gospel of John than in the Synoptics. This challenges scholars to read these sections in relation to Gnosticism. The article aims at reading the scenes dealing with Jude and Thomas in John's gospel with a Gnostic framework in mind. These texts gain more profile than ...

  9. Philosophical Creationism: Thomas Aquinas’ Metaphysics of Creatio ex Nihilo

    Directory of Open Access Journals (Sweden)

    Andrzej Maryniarczyk

    2016-03-01

    Full Text Available All philosophers, beginning with the pre-Socratics, through Plato and Aristotle, and up to Thomas Aquinas, accepted as a certain that the world as a whole existed eternally. The foundation for the eternity of the world was the indestructible and eternal primal building material of the world, a material that existed in the form of primordial material elements (the Ionians, in the form of ideas (Plato, or in the form of matter, eternal motion, and the first heavens (Aristotle. The article outlines the main structure of the philosophical theory of creation ex nihilo developed by St. Thomas Aquinas and indebted to his metaphysical thought. It shows the wisdom-based and ratiocinative foundation of the rational cognition of reality—reality that comes from the personal creative act of God. It concludes that the perception that the beings called to existence by the personal act of God the Creator are intelligible is the ultimate rational justification for the fact that our human cognition, love, and spiritual creativity are rational.

  10. Full depth bituminous recycling of I-70, Thomas County, Kansas

    Science.gov (United States)

    2004-01-01

    In 1990, 13 full depth asphalt pavement test sections were built on a portion of I-70 in Thomas County, Kansas. Various combinations of hot mix and cold recycle mixes with different additives were used to build the test sections. Two of the test sect...

  11. USA saadik loodab võita eestlaste poolehoiu / Joseph M. DeThomas

    Index Scriptorium Estoniae

    DeThomas, Joseph M.

    2003-01-01

    USA suursaadik Eestis Joseph DeThomas vastab on-line intervjuus Eesti Päevalehe lugejate küsimustele Iraagi ründamise, USA ja Euroopa vahelise lõhe, USA Eesti saatkonna võimaliku ümberkolimise kohta

  12. Satellite Assessment of Bio-Optical Properties of Northern Gulf of Mexico Coastal Waters Following Hurricanes Katrina and Rita

    Directory of Open Access Journals (Sweden)

    Merritt Tuel

    2008-07-01

    Full Text Available The impacts of major tropical storms events on coastal waters include sediment resuspension, intense water column mixing, and increased delivery of terrestrial materials into coastal waters. We examined satellite imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS ocean color sensor aboard the Aqua spacecraft following two major hurricane events: Hurricane Katrina, which made landfall on 29 August 2005, and Hurricane Rita, which made landfall on 24 September. MODIS Aqua true color imagery revealed high turbidity levels in shelf waters immediately following the storms indicative of intense resuspension. However, imagery following the landfall of Katrina showed relatively rapid return of shelf water mass properties to pre-storm conditions. Indeed, MODIS Aqua-derived estimates of diffuse attenuation at 490 nm (K_490 and chlorophyll (chlor_a from mid-August prior to the landfall of Hurricane Katrina were comparable to those observed in mid-September following the storm. Regions of elevated K_490 and chlor_a were evident in offshore waters and appeared to be associated with cyclonic circulation (cold-core eddies identified on the basis of sea surface height anomaly (SSHA. Imagery acquired shortly after Hurricane Rita made landfall showed increased water column turbidity extending over a large area of the shelf off Louisiana and Texas, consistent with intense resuspension and sediment disturbance. An interannual comparison of satellite-derived estimates of K_490 for late September and early October revealed relatively lower levels in 2005, compared to the mean for the prior three years, in the vicinity of the Mississippi River birdfoot delta. In contrast, levels above the previous three year mean were observed off Texas and Louisiana 7-10 d after the passage of Rita. The lower values of K_490 near the delta could be attributed to relatively low river discharge during the preceding months of the 2005 season. The elevated levels

  13. Land area change and fractional water maps in the Chenier Plain, Louisiana, following hurricane Rita

    Science.gov (United States)

    Palaseanu-Lovejoy, M.; Kranenburg, C.; Brock, J. C.

    2009-12-01

    The objective of this study is to develop a fractional water map at 30-m resolution scale using QuickBird and/or IKONOS high-resolution imagery as dependent variable to investigate the impact of hurricane Rita in the Chenier Plain, Louisiana. Eleven different indices were tested to obtain a high-resolution land / water classification on QuickBird (acquired on 05/23/2003) and IKONOS (acquired on 03/25/2006) images. The percent area covered by water in the high resolution images varied from 22 to 26% depending on the index used , with the simple ratio index (red band / NIR band) accounting for the lowest percent and the blue ratio index (blue band / sum(all bands)) for the highest percent. Using the ERDAS NLCD (National Land Cover Data) Mapping tool module, 100, 000 stratified random sample points with minimum 1000 points per stratum were selected from the high resolution dependent variable as training information for the independent variable layers. The rules for the regression tree were created using the data mining software Rulequest Cubist v. 2.05. This information was used to generate a fractional water map for the entire Landsat scene. The increase in water areas of about 10 - 15% between 2003 to 2006, as well as temporary changes in the water - land configurations are attributed to remnant flooding and removal of aquatic vegetation caused by hurricane Rita, and water level variations caused by tidal and / or meteorological variations between the acquisition dates of the satellite images. This analysis can assist in monitoring post-hurricane wetland recovery and assess trends in land loss due to extreme storm events, although estimation of permanent land loss cannot be made until wetland areas have the opportunity to recover from hurricane impacts.

  14. Teaching with Purpose: An Interview with Thomas E. Ludwig

    Science.gov (United States)

    Ludwig, Timothy D.; Ludwig, David J.

    2010-01-01

    Thomas E. Ludwig is the John Dirk Werkman Professor of Psychology at Hope College, where he joined the faculty in 1977 after receiving his PhD in development and aging from Washington University in St. Louis. His research focuses on developmental issues in cognitive neuropsychology. He is also the author or coauthor of more than a dozen sets of…

  15. C-CAP USVI, St. Thomas 2007-2012 Land Cover Change Analysis

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the 2007 and 2012 classifications of St. Thomas and can be used to analyze change. This data set utilized CIR imagery captured from Microsoft...

  16. some aspects of fisheries ecology in thomas dam, kano nigeria 192

    African Journals Online (AJOL)

    userpc

    The diversity, length-weight relationship and condition factor of fish species of Thomas Dam,. Dambatta Kano ..... of these species in northern Nigeria as reported ... obtained in other fresh water bodies within the .... North America, 1: 584-590.

  17. A Dialectics of Reason and Instinct: Thomas Mann’s Magic Mountain

    Directory of Open Access Journals (Sweden)

    Ciro Schmidt Andrade

    Full Text Available The whole Thomas Mann’s work is a reflection of the permanent tension between instinct and reason, the irruption of the repressed and life order. This is particularly manifested in his work The Magic Mountain.

  18. Jude the Obscure de Thomas Hardy et l’autorité de la lettre Jude the Obscure by Thomas Hardy and the Power of the Letter

    Directory of Open Access Journals (Sweden)

    Stéphanie Bernard

    2009-10-01

    Full Text Available Thomas Hardy is usually considered a Victorian writer. Nonetheless, his last novel Jude the Obscure, announced the era of modernity which started with the twentieth century, just before he abandoned fiction to concentrate on poetry. With modernity looming in the background, Jude the Obscure allowed for the rewriting of tragedy. Urban settings have replaced the countryside and all signs of transcendence have vanished from society. This defeat of the divine is nevertheless accompanied by a great number of biblical references. Thomas Hardy quotes and uses the Divine Letter as if to rewrite it rather than to appear faithful to the Word. The text keeps offering itself to the spell of voice: it does so when Job utters words of revolt and then worship, when Jude lets his imagination flow from his lips so that he seems to live on in the text after he is dead, or when the voice of the novelist becomes the voice of a poet.

  19. Thomas Mann's "Tobias Mindernickel" in Light of Sartre's "Being-for-Others"

    Directory of Open Access Journals (Sweden)

    Beth Bjorklund

    1978-01-01

    Full Text Available Sartre's analysis of "Being-for-Others" in Being and Nothingness describes the Self-Other relationship as essentially one of conflict, with the Self attempting either to dominate or to be dominated by the Other. Subject-Object relations are a common theme also in the early works of Thomas Mann, who gives artistic expression to many of the same problems which Sartre later formalized in a philosophical theory. The sado-masochistic character, which is portrayed in several of Thomas Mann's narratives, receives its strongest expression in the story "Tobias Mindernickel," which is here singled out for analysis. Humiliation gives rise to aggression, as the protagonist feels both an attraction and a repulsion for his surrogate lover, a dog. The interpersonal relationships revealed here serve as paradigmatic illustration of Sartre's theory of "Concrete Relations with Others."

  20. Two-centre interference effects on the Thomas two-step scattering mechanisms

    International Nuclear Information System (INIS)

    Adivi, E Ghanbari

    2010-01-01

    The charge transfer process in the collision of fast protons with hydrogen molecules is theoretically investigated using the second-order Born approximation with correct boundary conditions. In addition to two first-order terms, the present calculations include the three second-order terms which correspond to the Thomas two-step scattering mechanisms. The interference effects, due to the scattering of the particles from two atomic centres, on the electron capture differential cross sections vary significantly with the orientation of the molecule and with the impact energy. After the averaging over all molecular orientations the interference patterns disappear but the Thomas peak becomes more pronounced. These patterns are also apparent in the differential cross sections as a function of the angle between the molecular axis and the incident beam direction. The integrated cross sections are calculated and the results are compared with available experimental data.

  1. Insights into translation and the original text: Thomas Mofolo's Chaka

    African Journals Online (AJOL)

    This paper aims to explore the strategies applied during the translation of chosen passages from the original Sesotho text of Chaka by Thomas Mofolo into English. Insights expressed here originate from participation in the translation workshops during the conference on “Translating Mofolo”. Different stages of the ...

  2. Religious Conscience and Civic Conscience in Thomas Hobbes's Civic Philosophy.

    Science.gov (United States)

    Pepperell, Keith C.

    1989-01-01

    This article discusses Thomas Hobbes' concept of conscience, the historical context in which the concept was formulated, and Hobbes' conclusion that civil law takes precedence over religious conscience. Hobbes' views are related to the debate between Pratte and Losito over the interaction between religious and civic conscience. (IAH)

  3. Some aspects of fisheries ecology in Thomas dam, Kano Nigeria ...

    African Journals Online (AJOL)

    The diversity, length-weight relationship and condition factor of fish species of Thomas Dam, Dambatta Kano were studied fortnightly between November, 2016 and February, 2017. Fish species were collected using line nets, cast nets, hooks and traps; weighted to the nearest gram and standard length measured to the ...

  4. Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

    NARCIS (Netherlands)

    Michaelis, M.; Rothweiler, F.; Agha, B.; Barth, S.; Voges, Y.; Loeschmann, N.; von Deimling, A.; Breitling, R.; Doerr, H. Wilhelm; Roedel, F.; Speidel, D.; Cinatl, J.; Cinatl Jr., J.; Stephanou, A.

    Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3,

  5. Astronaut Thomas Stafford during water egress training in Gulf of Mexico

    Science.gov (United States)

    1965-01-01

    Astronaut Thomas P. Stafford, Gemini 6 prime crew pilot, climbs out of a boilerplate model of a Gemini spacecraft during water egress training in the Gulf of Mexico. A NASA swimmer in the water nearby assists in the exercise.

  6. Biological aspects and life table of Uroleucon ambrosiae (Thomas, 1878) as a function of temperature

    OpenAIRE

    Auad Alexander Machado; Moraes Jair Campos de

    2003-01-01

    The aphid Uroleucon ambrosiae (Thomas) is considered a pest of hidroponically-grown lettuce, but basic and applied information on its control are scarce in Brazil. The aim of this study was to determine the effect of different temperatures on biological aspects and life history of U. ambrosiae (Thomas) developing on hydroponic lettuce (Lactuca sativa L.) crop. Newly emerged nymphs were placed on 4-cm discs of hydroponic lettuce, var. Verônica, which were maintained on 5-cm Petri dishes, at te...

  7. Thomas Kibble visits CERN

    CERN Multimedia

    Rosaria Marraffino

    2014-01-01

    Emeritus Professor Sir Thomas W.B. Kibble, from Imperial College London visited LHC for the first time last week and delivered a colloquium on the genesis of electroweak unification and the Brout-Englert-Higgs mechanism.   From left to right: Jim Virdee, Tiziano Camporesi, Tom Kibble and Austin Ball on the visit to CMS. On his way back from Trieste, where he received the Abdus Salam International Centre for Theoretical Physics' Dirac Medal, Tom Kibble stopped by CERN for his first visit to the LHC. Kibble had a standing invitation from Jim Virdee, former CMS spokesperson, who is also a researcher from Imperial College London. Peter Jenni (left) and Tom Kibble tour the ATLAS detector. (Image: Erwan Bertrand) Kibble made the trip to CERN a family outing and brought along 14 relatives,  including his children and grandchildren. He visited the ATLAS detector with Peter Jenni, its former spokesperson, on Friday 10 October. In the afternoon, Kibble delivered a colloquium in the...

  8. ThomAs AquinAs: on LAW, TyrAnny And resisTAnce

    African Journals Online (AJOL)

    Thomas Aquinas's notion on law, tyranny and resistance served as a limitation on .... is obliged to disobey it, as did the holy martyrs who suffered death rather than ..... and, what is worse, he brings upon himself the most terrible penalty, namely.

  9. The perturbation of the condensed medium in the Thomas-Fermi model

    Science.gov (United States)

    Kyarov, A. Kh; Savintsev, A. P.

    2018-01-01

    The research presented in this work is the continuation of the previous studies, which gave a qualitative estimating solution of the problem. The aim of this work is the calculation of static perturbation of condensed medium in the Thomas-Fermi approximation.

  10. The Invention Factory: Thomas Edison's Laboratories. Teaching with Historic Places.

    Science.gov (United States)

    Bolger, Benjamin

    This lesson explores the group of buildings in West Orange, New Jersey, built in 1887, that formed the core of Thomas Edison's research and development complex. They consisted of chemistry, physics, and metallurgy laboratories; machine shop; pattern shop; research library; and rooms for experiments. The lesson explains that the prototypes (ideas…

  11. Lead distributions and risks in New Orleans following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Abel, Michael T; Cobb, George P; Presley, Steven M; Ray, Gary L; Rainwater, Thomas R; Austin, Galen P; Cox, Stephen B; Anderson, Todd A; Leftwich, Blair D; Kendall, Ronald J; Suedel, Burton C

    2010-07-01

    During the last four years, significant effort has been devoted to understanding the effects that Hurricanes Katrina and Rita had on contaminant distribution and redistribution in New Orleans, Louisiana, USA, and the surrounding Gulf Coast area. Elevated concentrations were found for inorganic contaminants (including As, Fe, Pb, and V), several organic pollutants (polycyclic aromatic hydrocarbons, pesticides, and volatiles) and high concentration of bioaerosols, particularly Aeromonas and Vibrio. Data from different research groups confirm that some contaminant concentrations are elevated, that existing concentrations are similar to historical data, and that contaminants such as Pb and As may pose human health risks. Two data sets have been compiled in this article to serve as the foundation for preliminary risk assessments within greater New Orleans. Research from the present study suggests that children in highly contaminated areas of New Orleans may experience Pb exposure from soil ranging from 1.37 microg/d to 102 microg/d. These data are critical in the evaluation of children's health. Copyright (c) 2010 SETAC.

  12. M O Ikeke Appraisal of Thomas Berry's Idea of Technological ...

    African Journals Online (AJOL)

    Oduor

    understanding of the natural world to the solution of practical problems”. According to ... technology is not needed, but its ethical use is imperative. We set out ... named William Nathan after his father, became known as Thomas, the name he took for his ..... Nigeria, oil companies do not follow the best international standards.

  13. Fasihi ya Kiswahili na rushwa Tanzania: Thomas A. R. Kamugisha ...

    African Journals Online (AJOL)

    Makala hii inajaribu kuelezea mchango wa fasihi ya Kiswahili katika kuijadili rushwa. Kwa kurejea kwenye Riwaya ya Thomas A.R. Kamugisha Kitu Kidogo tu! makala hii inasawilisha miongo takribani mitatu ya dhana ya “kitu kidogo” na athari zake kwa jamii ya Tanzania. Kwa kuijadili riwaya ya Kitu Kidogo tu! makala hii ...

  14. Recent infection testing algorithm (RITA) applied to new HIV diagnoses in England, Wales and Northern Ireland, 2009 to 2011.

    Science.gov (United States)

    Aghaizu, A; Murphy, G; Tosswill, J; DeAngelis, D; Charlett, A; Gill, O N; Ward, H; Lattimore, S; Simmons, Rd; Delpech, V

    2014-01-16

    In 2009, Public Health England (PHE) introduced the routine application of a recent infection testing algorithm (RITA) to new HIV diagnoses, where a positive RITA result indicates likely acquisition of infection in the previous six months. Laboratories submit serum specimens to PHE for testing using the HIV 1/2gO AxSYM assay modified for the determination of HIV antibody avidity. Results are classified according to avidity index and data on CD₄ count, antiretroviral treatment and the presence of an AIDS-defining illness. Between 2009 and 2011, 38.4% (6,966/18,134) of new HIV diagnoses in England, Wales and Northern Ireland were tested. Demographic characteristics of those tested were similar to all persons with diagnosed HIV. Overall, recent infection was 14.7% (1,022/6,966) and higher among men who have sex with men (MSM) (22.3%, 720/3,223) compared with heterosexual men and women (7.8%, 247/3,164). Higher proportions were among persons aged 15-24 years compared with those ≥50 years (MSM 31.2% (139/445) vs 13.6% (42/308); heterosexual men and women 17.3% (43/249) vs 6.2% (31/501)). Among heterosexual men and women, black Africans were least likely to have recent infection compared with whites (4.8%, 90/1,892 vs 13.3%, 97/728; adjusted odds ratio: 0.6; 95% CI: 0.4-0.9). Our results indicate evidence of ongoing HIV transmission during the study period, particularly among MSM.

  15. Thomas George Lee - Implantation and early development of North American rodents

    DEFF Research Database (Denmark)

    Carter, Anthony Michael

    2011-01-01

    A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst to the a......A century ago Thomas G. Lee amassed an unparalleled collection of developmental series of North American rodents such as the thirteen-lined ground squirrel, the Plains pocket gopher and Merriam's kangaroo rat. He was the first to describe the initial attachment of the squirrel blastocyst...... to the antimesometrial side of the uterus. The full potential of Lee's material was not realized until after his death, when it came into the possession of Mossman. The latter relied heavily on Lee's collection when writing his seminal monograph on the comparative morphogenesis of fetal membranes and much of Lee...

  16. Thomas Kuhn e a nova historiografia da ciência

    Directory of Open Access Journals (Sweden)

    Bernardo Jefferson de Oliveira

    2002-01-01

    Full Text Available This article tries to show the Thomas Kuhn's critics to some conceptions of the contemporary historiography of science that became radical many of the positions formulated initially by Kuhn himself. It is still intended to show that the new orientation of Kuhn, starting from his critic to his successors, approaches him more of his initial influences, especially, Ludwig Wittgenstein and Ludwik Fleck.

  17. Impacts of Hurricane Rita on the beaches of western Louisiana: Chapter 5D in Science and the storms-the USGS response to the hurricanes of 2005

    Science.gov (United States)

    Stockdon, Hilary F.; Fauver, Laura A.; Sallenger,, Asbury H.; Wright, C. Wayne

    2007-01-01

    Hurricane Rita made landfall as a category 3 storm in western Louisiana in late September 2005, 1 month following Hurricane Katrina's devastating landfall in the eastern part of the State. Large waves and storm surge inundated the lowelevation coastline, destroying many communities and causing extensive coastal change including beach, dune, and marsh erosion.

  18. Thomas precession: correct and incorrect solutions

    International Nuclear Information System (INIS)

    Malykin, Grigorii B

    2006-01-01

    A wealth of different expressions for the frequency of the Thomas precession (TP) can be found in the literature, with the consequence that this issue has been discussed over a long period of time. It is shown that the correct result was obtained in the works of several authors, which were published more than forty years ago but remained unnoticed against the background of numerous erroneous works. Several TP-related physical paradoxes formulated primarily to disprove the special relativity theory are shown to be fallacious. Different techniques for deriving the correct expression are considered and the reasons for the emergence of the main incorrect expressions for the TP frequency are analyzed. (from the history of physics)

  19. Thomas-Fermi theory for atomic nuclei revisited

    International Nuclear Information System (INIS)

    Centelles, M.; Schuck, P.; Vinas, X.

    2007-01-01

    The recently developed semiclassical variational Wigner-Kirkwood (VWK) approach is applied to finite nuclei using external potentials and self-consistent mean fields derived from Skyrme interactions and from relativistic mean field theory. VWK consists of the Thomas-Fermi part plus a pure, perturbative h 2 correction. In external potentials, VWK passes through the average of the quantal values of the accumulated level density and total energy as a function of the Fermi energy. However, there is a problem of overbinding when the energy per particle is displayed as a function of the particle number. The situation is analyzed comparing spherical and deformed harmonic oscillator potentials. In the self-consistent case, we show for Skyrme forces that VWK binding energies are very close to those obtained from extended Thomas-Fermi functionals of h 4 order, pointing to the rapid convergence of the VWK theory. This satisfying result, however, does not cure the overbinding problem, i.e., the semiclassical energies show more binding than they should. This feature is more pronounced in the case of Skyrme forces than with the relativistic mean field approach. However, even in the latter case the shell correction energy for e.g., 208 Pb turns out to be only ∼-6 MeV what is about a factor two or three off the generally accepted value. As an ad hoc remedy, increasing the kinetic energy by 2.5%, leads to shell correction energies well acceptable throughout the periodic table. The general importance of the present studies for other finite Fermi systems, self-bound or in external potentials, is pointed out

  20. Numerical comparison of atomic binding energies calculated by Thomas-Fermi like formulas

    International Nuclear Information System (INIS)

    Donnamaria, M.C.; Castro, E.A.; Fernandez, F.M.

    1985-01-01

    We apply in an exhaustive way formulas of Thomas-Fermi nature to determine atomic ground state energies. Results are compared with Hartree-Fock SCF data and the different methods are analysed in a comparative fashion. (authors)

  1. After Hurricanes Katrina and Rita: gender differences in health and religiosity in middle-aged and older adults.

    Science.gov (United States)

    Brown, Jennifer Silva; Cherry, Katie E; Marks, Loren D; Jackson, Erin M; Volaufova, Julia; Lefante, Christina; Jazwinski, S Michal

    2010-11-01

    We examined health-related quality of life in adults in the Louisiana Health Aging Study (LHAS) after Hurricanes Katrina and Rita (HK/R) that made landfall on the U.S. Gulf Coast region in 2005. Analyses of pre- and post-disaster SF-36 scores yielded changes in physical function and bodily pain. Mental health scores were lower for women than men. Gender differences were observed in religious beliefs and religious coping, favoring women. Religious beliefs and religious coping were negatively correlated with physical function, implying that stronger reliance on religiosity as a coping mechanism may be more likely among those who are less physically capable.

  2. CREACIÓN DE UN METAVERSO EN OPENSIM PARA LA UNIVERSIDAD DISTRITAL DENTRO DE LA RED RITA-UD

    Directory of Open Access Journals (Sweden)

    Nicolás Torres Vallejo

    2013-01-01

    Full Text Available Este paper contempla el montaje de un segmento de red inalámbrico para la red RITA-UD con el fin de brindar acceso a contenidos multimedia a través de un mundo virtual creado en OPENSIM. Los contenidos de las emisiones de streaming se encuentran almacenados en un servidor ubicado en el centro de computación de alto desempeño, CECAD. Al tiempo  que se realizaron pruebas de streaming multicast, se capturaron dichas transmisiones mediante el sniffer de paquetes WireShark con el fin de determinar parámetros de QoS que caractericen el canal.

  3. Manson Chicks and Microskirted Cuties : Pornification in Thomas Pynchon's Inherent Vice

    NARCIS (Netherlands)

    Cook, S.J.|info:eu-repo/dai/nl/411939432

    2015-01-01

    Many sexual encounters in Thomas Pynchon’s fiction have occurred beyond the mainstream, generating theatres of perversity which dramatise the death wish and enact power relations from wider arenas. However, in Inherent Vice they change in nature. With the exception of scenes which use Charles Manson

  4. Looking for the Silver Lining: Benefit Finding after Hurricanes Katrina and Rita in Middle-Aged, Older, and Oldest-Old Adults

    OpenAIRE

    Stanko, Katie E.; Cherry, Katie E.; Ryker, Kyle S.; Mughal, Farra; Marks, Loren D.; Brown, Jennifer Silva; Gendusa, Patricia F.; Sullivan, Marisa C.; Bruner, John; Welsh, David A.; Su, L. Joseph; Jazwinski, S. Michal

    2015-01-01

    Looking for potentially positive outcomes is one way that people cope with stressful events. In two studies, we examined perceived “silver linings” after the 2005 Hurricanes Katrina and Rita among indirectly affected adults. In Study 1, middle-aged (ages 47–64 years), older (ages 65–89 years), and oldest-old (ages 90–95 years) adults in the Louisiana Healthy Aging Study (LHAS) responded to an open-ended question on perceived silver linings in a longitudinal assessment carried out during the i...

  5. Derivation of the Euler equations in Thomas-Fermi theories of a hot nuclear system

    International Nuclear Information System (INIS)

    Wang, C.

    1992-01-01

    The variational extreme condition with respect to statistical distribution of nucleons in momentum space is applied to derive the Euler equation of the nuclear density profile. The resultant Euler equation of the nuclear density profile is proven to be identical with that obtained in the usual Thomas-Fermi theories of a hot nuclear system where the variation is made with respect to the nuclear density profile. A Fermi-Dirac-type distribution appears as a result of variation in the present approach, while it is used as a given expression in obtaining the variation of the nuclear density profile in the usual Thomas-Fermi theories

  6. Capital Grace of the Word Incarnate According to Saint Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Lucia Marie Siemering

    2016-06-01

    Full Text Available The doctrine of capital grace was developed during the Scholastic period and bears on many areas of theology including ecclesiology, Christology, sacraments, and Trinitarian theology with regard to the missions of the Word and the Holy Spirit. Viewed from a Christological standpoint, capital grace sheds light on how Christ in his human nature can be said to be a source of grace to the members of the Church. Following his contemporaries, the young Thomas Aquinas espoused a view in which Christ is a meritorious, ministerial, and dispositive cause of grace according to his human nature, and an efficient cause according to his divinity. After a deeper reading of John Damascene’s treatment of Christ’s humanity being an instrument of his divinity, Thomas was able to articulate a view in which Christ’s human nature is an instrumental efficient cause of grace. This view undergirds Aquinas’s strong conception of Christ as one acting person in two natures.

  7. Thomas Kuhn's revolutions a historical and an evolutionary philosophy of science?

    CERN Document Server

    Marcum, James A

    2015-01-01

    This new edition of Thomas Kuhn's Revolution marks the 50th anniversary of the publication of Kuhn's most influential work. Drawing on the rich archival sources at MIT, and engaging fully with current scholarship, James Marcum provides the historical background to the development of The Structure of Scientific Revolutions. Exploring the shift Kuhn makes from a historical to an evolutionary philosophy of science and examining Kuhn's legacy in depth, Marcum answers key questions: What exactly was Kuhn's historiographic revolution and how did it come about? Why did it have the impact it did? What will its future impact be for both academia and society? Marcum's answers build a new portrait of Kuhn: his personality, his pedagogical style and the intellectual and social context in which he practiced his trade. Thomas Kuhn's Revolution shows how Kuhn transcends the boundaries of the philosophy of science, influencing sociologists, economists, theologians and even policy makers and politicians. This is a comprehensi...

  8. Pierre Ambroise-Thomas: a loyal friend and a strong supporter of tropical medicine in Brazil.

    Science.gov (United States)

    Daniel-Ribeiro, Cláudio Tadeu

    2016-01-01

    Our colleagues at the Sociedade Brasileira de Medicina Tropical have been informed of the demise of Professor Pierre Ambroise-Thomas (1937-2014). However, considering that the tribute we paid to him in 2015 - at the 20th anniversary of the Seminário Laveran & Deane sobre Malária - is equally true today, it is worth sharing it with the readers of the RSBMT, in recognition of his many virtues. Pierre Ambroise-Thomas (MD in 1963 and DSc in 1969) was Honorary Professor of Parasitology and Tropical Medicine at the Faculté de Médecine de Grenoble (France), Honorary President of the Académie Nationale de Médecine, member of the Académie Nationale de Pharmacie and Officier dans l'Ordre de La Légion d'Honneur. In addition to his important contributions to tropical medicine and parasitology, working in France during his long and productive career (50 years and 300 publications), Ambroise-Thomas became an admirer and supporter of Brazilian activities related to research, teaching and information in Tropical Medicine.

  9. Pierre Ambroise-Thomas: a loyal friend and a strong supporter of tropical medicine in Brazil

    Directory of Open Access Journals (Sweden)

    Cláudio Tadeu Daniel-Ribeiro

    Full Text Available Abstract: Our colleagues at the Sociedade Brasileira de Medicina Tropical have been informed of the demise of Professor Pierre Ambroise-Thomas (1937-2014. However, considering that the tribute we paid to him in 2015 - at the 20th anniversary of the Seminário Laveran & Deane sobre Malária - is equally true today, it is worth sharing it with the readers of the RSBMT, in recognition of his many virtues. Pierre Ambroise-Thomas (MD in 1963 and DSc in 1969 was Honorary Professor of Parasitology and Tropical Medicine at the Faculté de Médecine de Grenoble (France, Honorary President of the Académie Nationale de Médecine, member of the Académie Nationale de Pharmacie and Officier dans l'Ordre de La Légion d'Honneur. In addition to his important contributions to tropical medicine and parasitology, working in France during his long and productive career (50 years and 300 publications, Ambroise-Thomas became an admirer and supporter of Brazilian activities related to research, teaching and information in Tropical Medicine.

  10. A Possible Source For Sir Thomas More’s ‘Mountainish Inhumanity’

    NARCIS (Netherlands)

    Steenbergh, Kristine

    2017-01-01

    Shakespeare’s authorship of a scene in Sir Thomas More has been established as highly probable on the basis of an analysis of the handwriting, vocabulary, and collocations stylistics. His addition to the play was long believed to have been written soon after publication of the original play, in

  11. Thomas Willis: the faculties and his two cognitive frameworks.

    Science.gov (United States)

    McNabb, Jody

    2014-11-01

    Thomas Willis' 1664 study The anatomy of the brain is widely regarded as one of the first clinical studies of the brain. In Theanatomy, Thomas Willis explicitly connected the cognitive faculties and the nerves. Willis' later, 1672 work, The two discourses concerning the soul of brutes, severely undermined the materialism of Willis' first study: he affirmed dualism and cognitive immateriality; changed the anatomical locations of cognition; and reasserted a division between the rational and sensitive souls. His exact motive to return to orthodoxy is unclear, but contemporary scholarship of Willis has compounded the confusion with by relying predominantly on The soul of brutes instead of The anatomy. We trace Willis' career and examine his methodological practices, which help explain the historical practices and pressures. A closer examination of Willis' Anatomy of the brain reveals a much more materialistic account of the brain, the faculties, and nervous system. In this article, we present our own analysis of Willis' concept of rationality in the Anatomy and explain its importance for nervous physiology and understanding the analytic techniques for first defining faculty localizations. We then explain the role of the imagination and the immortal soul in the rearticulated anatomical concepts from The soulof brutes. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Porter-Thomas distribution in unstable many-body systems

    International Nuclear Information System (INIS)

    Volya, Alexander

    2011-01-01

    We use the continuum shell model approach to explore the resonance width distribution in unstable many-body systems. The single-particle nature of a decay, the few-body character of the interaction Hamiltonian, and the collectivity that emerges in nonstationary systems due to the coupling to the continuum of reaction states are discussed. Correlations between the structures of the parent and daughter nuclear systems in the common Fock space are found to result in deviations of decay width statistics from the Porter-Thomas distribution.

  13. Quasi-four-body treatment of charge transfer in the collision of protons with atomic helium: I. Thomas related mechanisms

    Science.gov (United States)

    Safarzade, Zohre; Fathi, Reza; Shojaei Akbarabadi, Farideh; Bolorizadeh, Mohammad A.

    2018-04-01

    The scattering of a completely bare ion by atoms larger than hydrogen is at least a four-body interaction, and the charge transfer channel involves a two-step process. Amongst the two-step interactions of the high-velocity single charge transfer in an anion-atom collision, there is one whose amplitude demonstrates a peak in the angular distribution of the cross sections. This peak, the so-called Thomas peak, was predicted by Thomas in a two-step interaction, classically, which could also be described through three-body quantum mechanical models. This work discusses a four-body quantum treatment of the charge transfer in ion-atom collisions, where two-step interactions illustrating a Thomas peak are emphasized. In addition, the Pauli exclusion principle is taken into account for the initial and final states as well as the operators. It will be demonstrated that there is a momentum condition for each two-step interaction to occur in a single charge transfer channel, where new classical interactions lead to the Thomas mechanism.

  14. Sobre o desejo em Thomas Hobbes

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    Fernando Rodrigues Montes D'Oca

    2011-01-01

    Full Text Available O objetivo deste artigo é explicar o papel do desejo na filosofia política do filósofo inglês Thomas Hobbes. Para tanto, o presente estudo propõe-se apresentar: i. a razão por que Hobbes reivindica o desejo à política, i.a tratando da teoria da conservação do movimento, de Galileu Galilei, e i.b da felicidade como um sucesso contínuo na obtenção dos objetos de desejo; e ii. o papel do desejo no estado de natureza, já que este é determinante tanto para ii.a a entrada do homem no estado de guerra quanto ii.b para a saída deste estado.

  15. Thomas Alva Edison (170th Anniversary of His Birth)

    OpenAIRE

    V. P. Samokhin; E A. Tikhomirovа

    2017-01-01

    A brief overview of the major technical achievements of Thomas Edison, an outstanding American inventor, author of more than 1,000 US patents and several thousand patents in other countries, honorary academician of the USSR. Presents biographical information and details of the formation of Edison, his work as a telegrapher, organizing the world's first industrial research laboratory for the continuous development of technological innovations, as well as some interesting facts about his life a...

  16. Thomas N Bonner (1923-2003), medical historian.

    Science.gov (United States)

    Bickel, Marcel H

    2016-05-01

    Thomas Bonner made a long academic career, teaching medical history and higher education at several American universities and presiding over three of these. He engaged in politics for 2 years. As a historian of medicine, he published important books on topics including Midwestern medicine, medical education in the United States and in European countries, the entry of women into medicine in the 19th century and on the educator Abraham Flexner. His works were based on exhaustive research, penetrating analysis, language skills and the ability to explain complex information in understandable terms. Bonner lived a passionate life of commitment and devotion to various worthwhile causes. © The Author(s) 2014.

  17. Somatic experiencing treatment with social service workers following Hurricanes Katrina and Rita.

    Science.gov (United States)

    Leitch, M Laurie; Vanslyke, Jan; Allen, Marisa

    2009-01-01

    In a disaster, social service workers are often survivors themselves.This study examines whether somatic intervention using a brief (one to two session) stabilization model now called the Trauma Resiliency Model (TRM), which uses the skills of Somatic Experiencing (SE), can reduce the postdisaster symptoms of social service workers involved in postdisaster service delivery.The study was implemented with a nonrandom sample of 142 social service workers who were survivors of Hurricanes Katrina and Rita in New Orleans and Baton Rouge, Louisiana, two to three months after the disasters. Ninety-one participants received SE/TRM and were compared with a matched comparison group of 51 participants through the use of propensity score matching. All participants first received group psychoeducation. Results support the benefits of the brief intervention inspired by SE. The treatment group showed statistically significant gains in resiliency indicators and decreases in posttraumatic stress disorder symptoms. Although psychological symptoms increased in both groups at the three to four month follow-up, the treatment group's psychological symptoms were statistically lower than those of the comparison group.

  18. Shell model test of the Porter-Thomas distribution

    International Nuclear Information System (INIS)

    Grimes, S.M.; Bloom, S.D.

    1981-01-01

    Eigenvectors have been calculated for the A=18, 19, 20, 21, and 26 nuclei in an sd shell basis. The decomposition of these states into their shell model components shows, in agreement with other recent work, that this distribution is not a single Gaussian. We find that the largest amplitudes are distributed approximately in a Gaussian fashion. Thus, many experimental measurements should be consistent with the Porter-Thomas predictions. We argue that the non-Gaussian form of the complete distribution can be simply related to the structure of the Hamiltonian

  19. Warm ''pasta'' phase in the Thomas-Fermi approximation

    International Nuclear Information System (INIS)

    Avancini, Sidney S.; Menezes, Debora P.; Chiacchiera, Silvia; Providencia, Constanca

    2010-01-01

    In the present article, the 'pasta' phase is studied at finite temperatures within a Thomas-Fermi (TF) approach. Relativistic mean-field models, both with constant and density-dependent couplings, are used to describe this frustrated system. We compare the present results with previous ones obtained within a phase-coexistence description and conclude that the TF approximation gives rise to a richer inner ''pasta'' phase structure and the homogeneous matter appears at higher densities. Finally, the transition density calculated within TF is compared with the results for this quantity obtained with other methods.

  20. Thomas Berdmore, dentist of His Majesty, George III, and dental calculus.

    Science.gov (United States)

    Andreana, S; Andreana, G; Gonzalez, Y M; Ciancio, S

    1996-11-01

    Thomas Berdmore's book, Disorders of Deformities of the Teeth and Gums, presents examples of early concepts of preventive dentistry and treatment of periodontal diseases. Various aspects of dental calculus formation and composition are analyzed. Also the effects of periodontal disease as seen by Berdmore are discussed, and ways of treatment in 1770 summarized.

  1. Resistência de Biomphalaria peregrina de Santa Rita do Sapucaí, Minas Gerais, a infecção com três cepas de Schistosoma mansoni Resistance of Biomphalaria peregrina from Santa Rita do Sapucaí, State of Minas Gerais, Brazil, to infection with strain of Schistosoma mansoni

    Directory of Open Access Journals (Sweden)

    Cecília Pereira de Souza

    1988-12-01

    Full Text Available Descendentes do planorbídeo Biomphalaria peregrina, coletados em Santa Rita do Sapucaí, Minas Gerais, Brasil, foram expostos a miracídios de três cepas de Schistosoma mansoni: "LE" de Belo Horizonte, MG; "SJ" de São José dos Campos, SP e "AL" do Estado de Alagoas. Dentre 300 exemplares expostos, nenhum se infectou com as três cepas do trematódeo. Por outro lado, 300 exemplares de B. glabrata, dos grupos de controle, apresentaram taxas de infecção de 61,1 a 95,3% com as três cepas do trematódeo. As taxas de mortalidade de B. peregrina e de B. glabrata foram de 20,0 e de 28,0%, respectivamente.The descendants of the planorbid snail Biomphalaria peregrina, collected in the region of Santa rita do Sapucaí, Minas Gerais, Brazil, were exposed to miracidia of three strains of Schistosoma mansoni: "LE" strain from Belo Horizonte, State of Minas Gerais; "SJ", strain from São José dos Campos, State of São Paulo and "AL" strain from State of Alagoas. Of 300 snails exposed to miracidia of the three strains, none was infected. On the other hand, 300 Biomphalaria glabrata of the control groups showed infection rates of 61.1 to 95.3% with three strains. The mortality rates of B. peregrina and B. glabrata were 20% and 28%, respectively.

  2. Thomas Docherty. Culture and a New Experience of Democracy

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    Erik S. RORABACK

    2006-10-01

    Full Text Available Thomas Docherty’s freshly printed volume from Stanford University Press, Aesthetic Democracy, is requisite reading for all those thinking beings out there interested in the question of the inter-relation and even inter-articulation between culture and experience for a possible new encounter with the political that would inch toward a truer form of democracy for our current postmodern social spheres and spaces. Professor of English and Comparative Literature in the University of Warwick, long ...

  3. Thomas Aquinas on the Soul: Old problems, New Solutions. Guiding Premises for a Thomistic Synthesis

    Directory of Open Access Journals (Sweden)

    Yevgeniy Shilov

    2012-12-01

    Full Text Available This article examines two main approaches to the doctrine of the soul: that of Plato and that of Aristotle. Each of these approaches had its own development and its own interpretations. Plato and his school was more important during the Middle Ages. Through the neo-platonic philosophers it reached Saint Augustine and became a part of the western cultural and religious heritage until finally it was taken up by member of the Franciscan order - Roger Bacon and Bonaventure. But this paradigm could not solve a host of problems connected with the soul and many of them remained unresolved. The end of the twelfth century brought the growth of the universities and the teaching of Aristotle - a new paradigm - transmitted by the Arabic philosophers which was rediscovered by the West. Two commentators on Aristotle - Averroes and Avicenna -were the most important for the West, especially since Avicenna exerted a great influence on Albert the Great. But both Plato and Aristotle, when taken separately, proved to be quite useless in resolving certain problems. But Thomas Aquinas was able to splice the Gordian knot concealing a solution to the problem of the soul. By combining the psychology of Plato with the metaphysics of Aristotle, Thomas succeeded in creating a new concept of the human person. The author of this article has tried to explain the difficulties which faced Thomas and the way in which Thomas was able to resolve a problem which had troubled philosophy through the ages - the problem of reconciling Plato with Aristotle and finding a way to make their conflicting philosophies agree with each other

  4. TUZ, Resonance Integrals in Unresolved Region, Various Temperature, From Porter-Thomas Distribution

    International Nuclear Information System (INIS)

    Kuncir, G.F.

    1969-01-01

    1 - Nature of physical problem solved: TUZ computes resonance integrals for a wide variety of temperatures, compositions, and geometries for the unresolved resonances. 2 - Method of solution: The resonances are considered to be defined by an average over the Porter-Thomas distribution of neutron widths

  5. Backscatter 0.5m TIFF Mosaic of St. Thomas, US Virgin Islands, 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of the south shore of St. Thomas, US Virgin Islands. NOAA's NOS/NCCOS/CCMA Biogeography Team and...

  6. Thomas Hardy's Victorian Gothic: Reassessing Hardy's Fiction and His Gothic Sensibility.

    Science.gov (United States)

    Goldstein, Norma Walrath

    Proposing that Thomas Hardy's fiction exhibits strong Gothic sensibilities which offer insight into his artistic vision and add to the power of his fiction, creating a new form of the Gothic, a Victorian Gothic, this dissertation reassesses the Gothic strains in Hardy's fiction. The dissertation is in eight chapters: (1) Introduction to Hardy's…

  7. Parallel Directionally Split Solver Based on Reformulation of Pipelined Thomas Algorithm

    Science.gov (United States)

    Povitsky, A.

    1998-01-01

    In this research an efficient parallel algorithm for 3-D directionally split problems is developed. The proposed algorithm is based on a reformulated version of the pipelined Thomas algorithm that starts the backward step computations immediately after the completion of the forward step computations for the first portion of lines This algorithm has data available for other computational tasks while processors are idle from the Thomas algorithm. The proposed 3-D directionally split solver is based on the static scheduling of processors where local and non-local, data-dependent and data-independent computations are scheduled while processors are idle. A theoretical model of parallelization efficiency is used to define optimal parameters of the algorithm, to show an asymptotic parallelization penalty and to obtain an optimal cover of a global domain with subdomains. It is shown by computational experiments and by the theoretical model that the proposed algorithm reduces the parallelization penalty about two times over the basic algorithm for the range of the number of processors (subdomains) considered and the number of grid nodes per subdomain.

  8. On the Road with Thomas Hart Benton: Images of a Changing America.

    Science.gov (United States)

    Johnson, Mark M.

    1999-01-01

    Summarizes the life and work of artist Thomas Hart Benton. Focuses on his paintings of the United States that capture the characteristics of regional life, customs, and nature before modern advancements and urbanization. Provides the itinerary for the 14- venue tour of 77 of Benton's works. (CMK)

  9. St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The 1/3 arc-second St. Thomas and St. John, U.S. Virgin Islands Coastal Digital Elevation Model will be used to support NOAA's tsunami forecast system and for...

  10. National Status and Trends: Bioeffects Program - St. Thomas East End Reserves (STEER) Database

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this effort was to characterize the extent and magnitude of chemical contamination in the St. Thomas East End Reserves or STEER, as part of a larger...

  11. Thomas Merton’s poetics of translation in his letters to writers

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    Marcela María Raggio

    2016-05-01

    Full Text Available This article explores Thomas Merton’s poetics of translation as reflected in his letters to writers. There, Merton expresses his ideas on poetic translation, the methods and the experience of approaching foreign literature through translation. Then, a translation analysis of a sample revises the connection between Merton’s poetics and practice of translation.

  12. Mythe en macht. Over de kritische psychiatrie van Thomas S. Szasz

    NARCIS (Netherlands)

    Pols, Jan

    1984-01-01

    The aim of this study is to present a review and a critical evaluation of the work of Thomas S. Szasz. First of all the extensive work of Szasz has been studied, resulting in a resumé of his views regarding psychiatry, mental illness, and psychiatrists and their patients. The work of Szasz is to be

  13. Rezension zu: Rita Pawlowski (Hg.: „Unsere Frauen stehen ihren Mann“. Berlin: trafo Wissenschaftsverlag 2008

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    Susanne Freund

    2009-07-01

    Full Text Available Rita Pawlowski stellt in diesem Band in alphabethischer Ordnung insgesamt 651 Frauen vor, die Abgeordnete der Volkskammer der DDR waren. Nach einer knappen Einführung zur Wahlhäufigkeit weiblicher Abgeordneter, zum Frauenanteil in der Volkskammer und in den Ausschüssen geben die Biographen im Wesentlichen Auskunft über die soziale Herkunft, die Parteizugehörigkeit, die schulische und berufliche Ausbildung und die Berufstätigkeit der einzelnen Frauen. Ziel dieses Bandes ist die Dokumentation des außergewöhnlichen Engagements von Frauen in der DDR, neben Berufstätigkeit und Familienpflichten politische Einflussmöglichkeiten zu nutzen. Damit wird ein Teilaspekt der Lebensgeschichte dieser Frauen beleuchtet, der – wie die Autorin im Vorfeld einräumt – keinen Anspruch auf Vollständigkeit erhebt. Dieser Hinweis ist wichtig, um dieses lexikalische Nachschlagewerk sinnvoll zu handhaben.

  14. Nom comú i nom propi segons Thomas Hobbes

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    Josep Moran i Ocerinjauregui

    2014-01-01

    Full Text Available Thomas Hobbes (1588-1679 tracta el llenguatge humà, i més concretament els noms, des d’un punt de vista filosòfic. Per a Hobbes, els noms són designadors de conceptes: els noms propis designen una sola cosa mentre que els noms comuns en designen diverses. Aquestes idees van ser objecte de reflexió filosòfica i van tenir gran influència en altres filòsofs, com John Stuart Mill.

  15. Losing Thomas & Ella: A Father's Story (A Research Comic).

    Science.gov (United States)

    Weaver-Hightower, Marcus B

    2017-09-01

    "Losing Thomas & Ella" presents a research comic about one father's perinatal loss of twins. The comic recounts Paul's experience of the hospital and the babies' deaths, and it details the complex grieving process afterward, including themes of anger, distance, relationship stress, self-blame, religious challenges, and resignation. A methodological appendix explains the process of constructing the comic and provides a rationale for the use of comics-based research for illness, death, and grief among practitioners, policy makers, and the bereaved.

  16. Remediation System Evaluation, Tutu Wellfield Superfund Site, St. Thomas, U.S. Virgin Islands

    Science.gov (United States)

    The Tutu Wellfield Superfund Site is a 1.5 square mile site located on the eastern end of St. Thomas, U.S. Virgin Islands (USVI) within the upper Turpentine Run surface drainage basin in the Anna’s Retreat area.

  17. Thomas Henry Huxley et la Bible Thomas Henry Huxley and the Bible

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    Christophe Duvey

    2009-10-01

    Full Text Available Thomas Henry Huxley devoted several essays to the study of the Bible. This interest can only be accounted for if his ideas on history, religion as well as epistemology are examined. According to him, a struggle between free thought and supernaturalism was culminating during the Victorian era, hence the need for a “New Reformation” which was heir to the ideals of freedom defended by the humanists of the Renaissance. This movement opposed the principles of the supporters of what he called “ecclesiasticism”. The advocates of the “New Reformation” could rely on the progress of modern science, and agnosticism, which Huxley identified with scientific method, became its epistemological foundation. As a result, Huxley thought that the authority of physical science was in conflict with the infallibility of the Scriptures and with the theological arguments which rested on it, and this notably led him to the conclusion that the biblical narrative of the Flood was unhistorical. The naturalisation of the Scriptures seems then logically to follow his philosophical views based on the limits of human knowledge.It appears that it was the question of authority which underlay Huxley’s interest in the Bible. He thought that the authority of the Scriptures must be replaced by that of science.

  18. Argumen Eksistensi Tuhan Dalam Metafisika Ibn Rusyd Dan St. Thomas Aquinas

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    Wardani Wardani

    2015-06-01

    Full Text Available Abstract : To establish an argumentation for the existence of God is properly the most crucial as well as complicated effort in the life of religion and faith of human being. There are various approaches and methods have been applicated to reach it by theologians, thinkers, and scientists, including philosophers with their demonstrative-philosophical method. Some arguments which were initiated by Aristotle are ones of the most popular and have been adopted and improved as well by many thinkers and philosophers after him, some arguments which proposed by Ibn Rusyd and St. Thomas Aquinas with some modifications and improvisations are the best examples of it. In the case of elaboration and analysis toward those arguments for the existence of God, this article attempts to compare between metaphysical thought of Ibn Rushd (well-known in the West as Averroës and St. Thomas Aquinas. There is no doubt that both are Aristotelian in their philosophy. Therefore, to seek the similarities and differences, and to analyze the influence of Aristotle on their modes of thought, especially in argumentation for the existence of God, are an urgent point in the way to find more stronger and relevant arguments.Keywords: argument of creation (dalīl al-ikhtirā`, teleological argument (dalīl al-‘ināyah, unmoved mover, prime cause, influence, parallelism.Abstrak : Menggagas argumentasi tentang eksistensi Tuhan sejatinya merupakan upaya yang paling krusial sekaligus pelik dalam kehidupan beragama dan kepercayaan umat manusia. Berbagai pendekatan dan metode telah ditempuh untuk meraihnya oleh para teolog, pemikir, dan ilmuwan, termasuk para filsuf dengan pendekatan dan metode demonstratif-filosofisnya. Argumen-argumen yang diprakarsai oleh Aristoteles adalah diantara yang paling populer dan telah diadopsi serta dikembangkan oleh para pemikir dan filsuf setelahnya, tak terkecuali argumen-argumen yang Ibn Rusyd dan St. Thomas Aquinas kemukakan dengan segenap modifikasi

  19. A Cáritas brasileira e a Economia Popular Solidária: O Agente de Cáritas e a Caridade Libertadora (Brazilian Caritas and the Popular Solidarity Economy: The Agent of Caritas and the Charity Liberating - DOI: 10.5752/P.2175-5841.2013v11n32p1506

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    Joannes Paulus Silva Forte

    2013-12-01

    Full Text Available O presente artigo analisa as ligações entre a Cáritas Brasileira e a Economia Popular Solidária a partir do trabalho do Agente de Cáritas. A problemática central do artigo remete às representações sociais que esses Agentes constroem em seus relatos sobre os princípios da Teologia da Libertação que norteiam os projetos em economia solidária da referida instituição religiosa. A metodologia de base qualitativa e etnográfica consistiu na realização da revisão bibliográfica, consulta a materiais institucionais, observação in loco e entrevistas semiestruturadas com Agentes que atuam na Economia Popular Solidária no estado do Ceará. A análise das representações sinaliza que a própria noção de “Reino de Deus” na terra pressupõe a vinculação profunda entre religião e economia, mística e movimentos sociais, religião e Estado, configurando, dessa forma, um projeto de sociedade contra hegemônico que se vislumbra mediante a transformação radical da base econômica e moral do tecido social contrapondo individualismo à solidariedade. Palavras-chave: Cáritas Brasileira. Economia Popular Solidária. Caridade Libertadora. Teologia da Libertação.  Abstract This article examines the links between Brazilian Caritas and Popular Solidarity Economy from the work of Caritas Agent. The central issue of the article refers to the social representations that these agents build in his histories about the principles of Liberation Theology that guide the projects in solidarity economy of that religious institution. The basic methodology used was qualitative and ethnographic; It consisted in literature review, consultation to institutional materials, observation in loco and semi-structured interviews with agents who act in the Popular Solidarity Economy in the state of Ceará. The analysis of representations indicates that the very notion of "Kingdom of God" on earth presupposes deep linking between religion and economics, mystic

  20. Tres cartas para la traición de Rita Hayworth

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    José Amícola

    1996-11-01

    Full Text Available El artículo trata la relación entre los manuscritos previos a la escritura de la primera novela de Manuel Puig y la novela terminada [de 1968]. El capítulo inserto cerca del final de la novela [en forma de'carta anónima'] habla asimismo de la voluntad de conformar una estructura armónica, donde surja un movimiento bipolar de ritmo distendido versus otro agitado, a la vez que obliga a la participación del lector en la tarea de la identidad del presunto remitente del anónimo. La segunda carta analizada [el último capítulo de la novela] nos lleva al centro de una crítica genética en la que se evidencia el trabajo de pulimiento del broche final, como clave de todo el texto. La tercera carta analizada aquí [borrador de carta del escritor a la actriz Rita Hayworth, de 1966], es un paratexto [es decir: un texto no ficcional independiente]. El borrador de esa carta a la actriz que da nombre a la obra sirve al geneticista como piedra de toque para descubrir la intención autorial con respecto al núcleo argumental de la novela, un núcleo que los esquemas pre-textuales anunciaban como 'la verdad'

  1. Vigencia de algunas de las ideas mercantilistas de Thomas Mun

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    Emmanuel Borgucci

    2011-01-01

    Full Text Available Generalmente cuando se aborda el mercantilismo se hace referencia a la acumulación de oro y plata, una balanza de pagos favorable o a la política económica de Jean Colbert. Pero poco se ha hablado del papel y condiciones necesarias del comerciante como agente que hizo posible que los primeros Estados-Nación se convirtieran en las futuras potencias económicas del mundo occidental. Thomas Mun fue uno de aquellos escritores mercantilistas que destacó el papel del comerciante en el auge del sistema mercantilista. El estudio de sus ideas permite concluir que sus recomendaciones acerca de lo que debería ser un comerciante de éxito siguen vigentes hoy en día. La razón de tal afirmación estriba en que sus recomendaciones eran adecuadas en un marco en que se estaba presentando una transformación significativa del sistema de organización comercial con la presencia de la Joint-Stock Company. Independientemente de que muchas de las funciones que Thomas Mun le atribuía al comerciante hoy en día son especializadas, su dominio sigue siendo la clave del éxito de una política comercial que emprenda cualquier nación.

  2. The Multiple Life of Nerve Growth Factor: Tribute to Rita Levi-Montalcini (1909-2012

    Directory of Open Access Journals (Sweden)

    Luigi Aloe

    2013-03-01

    Full Text Available At the end of the 19th century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM discovering the nerve growth factor (NGF. Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

  3. In vitro propagation of Phalaenopsis (Orchidaceae from protocorms, using the temporary inmersion system "RITA"

    Directory of Open Access Journals (Sweden)

    Jorge Mario Tirado

    2005-01-01

    Full Text Available In order to massively propagate Phalaenopsis orchids, three months old in vitro protocorms were transferred to RITA® vessels. The evaluation factors were the sucrose concentration in the culture medium and the frequency immersion. There was a set of five pairs of RITA® vessels with liquid culture medium containing sucrose at 0,15, 30, 45, 60 g/L. A half-strength MS medium plus vitamins, supplemented with vitamins and thidiazuron (5 mg/L was used. The experiment had two stages, each lasting two months. Each stage had a one minute immersion. The first stage had a four hour immersion frequency and the second one had an eight hour immersion frequency. Results showed that the best proliferating response was reached in a 15 g/L of sucrose medium with one minute of immersion time every four hours, resulting in 8,2 adventitious protocorms per protocorm per month. Key words: Phalaenopsis, protocorm, in vitro propagation, temporary immersion, RITA.

  4. The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012).

    Science.gov (United States)

    Aloe, Luigi; Chaldakov, George N

    2013-03-01

    At the end of the 19(th) century, it was envisaged by Santiago Ramon y Cajal, but not, proven, that life at the neuronal level requires trophic support. The proof was obtained in the early 1950's by work initiated by Rita Levi-Montalcini (RLM) discovering the nerve growth factor (NGF). Today, NGF and its relatives, collectively designated neurotrophins, are well recognized as mediators of multiple biological phenomena in health and disease, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other neurotrophins are implicated in the pathogenesis of a large spectrum of neuronal and non-neuronal diseases, from Alzheimer's and other neurodegenerative diseases to atherosclerosis and other cardiometabolic diseases. Recent studies demonstrated the therapeutic potentials of NGF in these diseases, including ocular and cutaneous diseases. Furthermore, NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma, and urinary bladder syndromes. Altogether, NGF's multiple potential in health and disease is briefly described here.

  5. [Thomas Schwencke and Wolfgang Amadeus Mozart].

    Science.gov (United States)

    Hillen, Harry F P

    2010-01-01

    Thomas Schwencke (1694-1767) was Professor of Anatomy and Surgery and Lecturer in Obstetrics at the Surgical School in The Hague, the Netherlands. In 1743 he published the very first textbook on haematology. Furthermore, he described his observations on the variolation of smallpox, and published the design of a new obstetric instrument. Schwencke was physician of the city of The Hague and also physician at the court of the princes van Nassau-Weilburg. In 1765 Princess Caroline of Nassau-Weilburg invited the young Wolfgang Amadeus Mozart to perform concerts. During his Dutch tour the young Mozart fell seriously ill, probably from typhoid fever. At the request of the court Mozart was seen for a second opinion and thereafter successfully treated by Schwencke. Mozart could continue his concert tour and Schwencke's reputation as Mozart's physician was established.

  6. The Importance of Peer Review: Thoughts on Knudson, Morrow, and Thomas (2014)

    Science.gov (United States)

    Fischman, Mark G.

    2014-01-01

    Knudson, Morrow, and Thomas (2014) recently summarized a number of important issues related to the quality of peer review and current peer-review practice in kinesiology. This writer endorses their six recommendations for improving peer review in kinesiology journals. The purpose of this commentary is to further highlight the importance of…

  7. Thomas L. Griffiths: Award for Distinguished Scientific Early Career Contributions to Psychology

    Science.gov (United States)

    American Psychologist, 2012

    2012-01-01

    Presents a short biography of one of the winners of the American Psychological Association's Award for Distinguished Scientific Early Career Contributions to Psychology (2012). Thomas L. Griffiths won the award for bringing mathematical precision to the deepest questions in human learning, reasoning, and concept formation. In his pioneering work,…

  8. Logical consistence and operating base in Thomas Hobbes. [Spanish

    Directory of Open Access Journals (Sweden)

    Rusbel Martínez Rodríguez

    2006-01-01

    Full Text Available The aim of this paper is to specify the operative elements included in the Thomas Hobbes philosophy substratum. I defend the idea that the logic in the Hobbes philosophy system depends on this substratum. In this paper I use the idea of «operative and thematic concepts» development by Eugen Fink. These concepts are used to show how all of the Hobbes philosophy system has explicit and implicit concepts. Another aim is to concede the importance of understanding the Hobbes philosophy as holistic.

  9. Thomas Edison, le magicien de Menlo Park la vie lumineuse d'un inventeur insatiable

    CERN Document Server

    Reyners, Benjamin; Klein-Scholz, Christelle

    2015-01-01

    Découvrez enfin tout ce qu'il faut savoir sur Thomas Edison et ses inventions en moins d'une heure ! Inventeur de génie, Thomas Edison est aussi l'un des plus prolifiques de tous les temps. Pourtant, rien ne laissait présager un tel destin... Peu scolarisé, il est d'abord vendeur de journaux à 12 ans, puis télégraphiste à 15, avant de devenir l'un des meilleurs ingénieurs de Wall Street à seulement 22 ans. Il ne cesse dès lors d'accumuler les succès. Doté d'une curiosité insatiable et passionné depuis l'enfance par les expériences en tous genres, il crée coup sur coup les plus grandes inventio

  10. Thomas H. Shepard, M.D., pioneer in embryology and teratology.

    Science.gov (United States)

    Fantel, Alan G; Polifka, Janine E; Oakley, Godfrey P

    2017-06-01

    Dr. Thomas H. Shepard died on October 3, 2016 at the age of 93. He was a major figure in the fields of teratology, embryonic and fetal pathology, and pediatrics. He was beloved by his colleagues as he was by the many students and fellows whom he taught, mentored and befriended. His contributions to teratology are extraordinary and he is greatly missed. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  11. Samuel Thomas Soemmerring (1755-1830): The Naming of Cranial Nerves.

    Science.gov (United States)

    Pearce, John M S

    2017-01-01

    Samuel Thomas Soemmerring was a Prussian polymathic doctor with remarkable achievements in anatomy, draftsmanship and inventions. His naming of 12 pairs of cranial nerves in his graduation thesis is of particular importance. He also gave original descriptions of the macula, sensory pathways and of the substantia nigra. His non-medical contributions were diverse and included criticism of the guillotine, invention of a telegraphic system, and discoveries in palaeontology. © 2017 S. Karger AG, Basel.

  12. EAARL-B Submerged Topography - Saint Croix and Saint Thomas, U.S. Virgin Islands, 2014

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Binary point-cloud data for part of the submerged environs of Saint Croix and Saint Thomas, U.S. Virgin Islands, were produced from remotely sensed, geographically...

  13. Equations of State of Elements Based on the Generalized Fermi-Thomas Theory

    Science.gov (United States)

    Feynman, R. P.; Metropolis, N.; Teller, E.

    1947-04-28

    The Fermi-Thomas model has been used to derive the equation of state of matter at high pressures and at various temperatures. Calculations have been carried out both without and with the exchange terms. Discussion of similarity transformations lead to the virial theorem and to correlation of solutions for different Z-values.

  14. FEMALE SURVIVORS IN THOMAS HARDY‘S THE WITHERED ARM

    Directory of Open Access Journals (Sweden)

    Yulistiyanti Yulistiyanti

    2017-12-01

    Full Text Available This article discusses women position in society that Thomas Hardy portrays in his short story entitled The Withered Arm. This short story tells about two female character have closerelationship to the same man. The man comes from upper class. The first woman from lower class has a son of his, but they do not live together. Then, the second one is his new young wife. This short story takes rural area, Dorset as the setting of place where the society has intimate relationships and setting of time is in Victorian era. It applied feminism theory that focuses on male and female positions in society. Beauvoir (1949 considered that the male in French and Western societies defines what it means to be human and what it means to be female. The female becomes subordinate to the male. It applies qualitative analysis method. The text is analyzed relating to the female characters‘ position in society. Their positions make them get discrimination which society created. Thomas Hardy‘s short story will be analyzed on discrimination to female characters. The data shows that the two female characters are oppressed on their conditions. Although they do not get physical harassment, the oppression comes from social injustice that women do not get equal benefit and opportunities. Both of them survive to obtain what they need. These characters use their ways as the survivors because of unfair condition.

  15. Thomas M. Prymak. Gathering a Heritage: Ukrainian, Slavonic, and Ethnic Canada and the USA

    Directory of Open Access Journals (Sweden)

    Danielle Morrissette

    2017-03-01

    Full Text Available Book review of Thomas M. Prymak. Gathering a Heritage: Ukrainian, Slavonic, and Ethnic Canada and the USA. U of Toronto P, 2015. xiv, 370 pp. Illustrations. Tables. Appendix. Notes. Index. $29.95, paper.

  16. Reply to comment by Thomas on ''On rainbow scattering in inelastic molecular collisions''

    International Nuclear Information System (INIS)

    Bowman, J.M.; Lee, K.T.

    1981-01-01

    The comments of Thomas 1 on the location of rainbows in inelastic molecular scattering of Ref. 2 are discussed and evaluated. It is contended that more insight into the nature of reainbows in rotatinally inelstic collisions is obtained by using the arguments in ref. 2

  17. A Tony Thomas-Inspired Guide to INSPIRE

    Energy Technology Data Exchange (ETDEWEB)

    O' Connell, Heath B.; /Fermilab

    2010-04-01

    The SPIRES database was created in the late 1960s to catalogue the high energy physics preprints received by the SLAC Library. In the early 1990s it became the first database on the web and the first website outside of Europe. Although indispensible to the HEP community, its aging software infrastructure is becoming a serious liability. In a joint project involving CERN, DESY, Fermilab and SLAC, a new database, INSPIRE, is being created to replace SPIRES using CERN's modern, open-source Invenio database software. INSPIRE will maintain the content and functionality of SPIRES plus many new features. I describe this evolution from the birth of SPIRES to the current day, noting that the career of Tony Thomas spans this timeline.

  18. A Tony Thomas-Inspired Guide to INSPIRE

    International Nuclear Information System (INIS)

    O'Connell, Heath B.

    2010-01-01

    The SPIRES database was created in the late 1960s to catalogue the high energy physics preprints received by the SLAC Library. In the early 1990s it became the first database on the web and the first website outside of Europe. Although indispensible to the HEP community, its aging software infrastructure is becoming a serious liability. In a joint project involving CERN, DESY, Fermilab and SLAC, a new database, INSPIRE, is being created to replace SPIRES using CERN's modern, open-source Invenio database software. INSPIRE will maintain the content and functionality of SPIRES plus many new features. I describe this evolution from the birth of SPIRES to the current day, noting that the career of Tony Thomas spans this timeline.

  19. Thomas Piketty’s capitalism revisited

    Directory of Open Access Journals (Sweden)

    Milovanović Milić

    2015-01-01

    Full Text Available Thomas Piketty’s international best selling Capital in the Twenty-First Century lays out his theory of a long-run rise in income inequality under capitalism. It is written as a manifesto urging reintegration of social sciences. A number of reviewers judged it on ideological grounds, labeling it either as a revolution in economic thinking, or dismissing it offhandedly. Piketty’s theory of rising inequality is based on the two Fundamental Laws of Capitalism, developed after the Solow growth model. However, this model is inconsistent with Piketty’s own characterization of modern capitalism. Moreover, his sole justification for the constant discrepancy between rate of return and rate of income growth (r > g is based on the high elasticity of substitution between capital and labor. However, that is just one factor that can have an influence on factor income shares. By failing to offer a consistent theory of rising inequality, his piece can hardly be considered as a useful founding stone for a new social science.

  20. The nuclear Thomas-Fermi model

    International Nuclear Information System (INIS)

    Myers, W.D.; Swiatecki, W.J.

    1994-08-01

    The statistical Thomas-Fermi model is applied to a comprehensive survey of macroscopic nuclear properties. The model uses a Seyler-Blanchard effective nucleon-nucleon interaction, generalized by the addition of one momentum-dependent and one density-dependent term. The adjustable parameters of the interaction were fitted to shell-corrected masses of 1654 nuclei, to the diffuseness of the nuclear surface and to the measured depths of the optical model potential. With these parameters nuclear sizes are well reproduced, and only relatively minor deviations between measured and calculated fission barriers of 36 nuclei are found. The model determines the principal bulk and surface properties of nuclear matter and provides estimates for the more subtle, Droplet Model, properties. The predicted energy vs density relation for neutron matter is in striking correspondence with the 1981 theoretical estimate of Friedman and Pandharipande. Other extreme situations to which the model is applied are a study of Sn isotopes from 82 Sn to 170 Sn, and the rupture into a bubble configuration of a nucleus (constrained to spherical symmetry) which takes place when Z 2 /A exceeds about 100

  1. The «Heterenomy» of Kantian Will. A Comparison with Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    María Elton

    2013-05-01

    Full Text Available The Kantian ideal is to establish a rational foundation of morality, accessible to everybody, independently of each own religiuos beliefs or even in absence of these beliefs. However, the Kantian practical reason does not ultimately fulfill this ideal, because the subject must have rational faith in the existence of God in order to promote its object, the supreme good, that is, the union between morality and its proportional happiness. God is the cause of this harmony in the afterlife. The cause of this reason’s «heteronomy» is precisely Kant’s foundation of the autonomy of will. At the bottom of this problem lies the question of how moral law influences man’s desire in order that his reason could be really practical. Thomas Aquinas has this problem resolved thanks to his metaphysical anthropology. According to Thomas, the origin of human acts resides in the agent, who moves himself for an end not only known, but also desired, being thus the owner of his actions with a kind of «personal autonomy»

  2. Applications of density matrix in the fractional quantum mechanics: Thomas-Fermi model and Hohenberg-Kohn theorems revisited

    International Nuclear Information System (INIS)

    Dong, Jianping

    2011-01-01

    The many-body space fractional quantum system is studied using the density matrix method. We give the new results of the Thomas-Fermi model, obtain the quantum pressure of the free electron gas. We also show the validity of the Hohenberg-Kohn theorems in the space fractional quantum mechanics and generalize the density functional theory to the fractional quantum mechanics. -- Highlights: → Thomas-Fermi model under the framework of fractional quantum mechanics is studied. → We show the validity of the HK theorems in the space fractional quantum mechanics. → The density functional theory is generalized to the fractional quantum mechanics.

  3. A Prospective Study of Religiousness and Psychological Distress Among Female Survivors of Hurricanes Katrina and Rita

    Science.gov (United States)

    Rhodes, Jean E.; Pérez, John E.

    2013-01-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose. PMID:21626083

  4. Bacteriological water quality in the Lake Pontchartrain basin Louisiana following Hurricanes Katrina and Rita, September 2005

    Science.gov (United States)

    Stoeckel, Donald M.; Bushon, Rebecca N.; Demcheck, Dennis K.; Skrobialowski, Stanley C.; Kephart, Christopher M.; Bertke, Erin E.; Mailot, Brian E.; Mize, Scott V.; Fendick, Robert B.

    2005-01-01

    The U.S. Geological Survey (USGS), in collaboration with the Louisiana Department of Environmental Quality, monitored bacteriological quality of water at 22 sites in and around Lake Pontchartrain, La., for three consecutive weeks beginning September 13, 2005, following hurricanes Katrina and Rita and the associated flooding. Samples were collected and analyzed by USGS personnel from the USGS Louisiana Water Science Center and the USGS Ohio Water Microbiology Laboratory. Fecal-indicator bacteria (Escherichia coli, enterococci, and fecal coliform) concentrations ranged from the detection limit to 36,000 colony-forming units per 100 milliliters. Data are presented in tabular form and as plots of data in the context of available historical data and water-quality standards and criteria for each site sampled. Quality-control data were reviewed to ensure that methods performed as expected in a mobile laboratory setting.

  5. A prospective study of religiousness and psychological distress among female survivors of Hurricanes Katrina and Rita.

    Science.gov (United States)

    Chan, Christian S; Rhodes, Jean E; Pérez, John E

    2012-03-01

    This prospective study examined the pathways by which religious involvement affected the post-disaster psychological functioning of women who survived Hurricanes Katrina and Rita. The participants were 386 low-income, predominantly Black, single mothers. The women were enrolled in the study before the hurricane, providing a rare opportunity to document changes in mental health from before to after the storm, and to assess the protective role of religious involvement over time. Results of structural equation modeling indicated that, controlling for level of exposure to the hurricanes, pre-disaster physical health, age, and number of children, pre-disaster religiousness predicted higher levels of post-disaster (1) social resources and (2) optimism and sense of purpose. The latter, but not the former, was associated with better post-disaster psychological outcome. Mediation analysis confirmed the mediating role of optimism and sense of purpose.

  6. Eye of the storm: analysis of shelter treatment records of evacuees to Acadiana from Hurricanes Katrina and Rita.

    Science.gov (United States)

    Caillouet, L Philip; Paul, P Joseph; Sabatier, Steven M; Caillouet, Kevin A

    2012-01-01

    The objective of this study is to gain insight into the medical needs of disaster evacuees, through a review of experiential data collected in evacuation shelters in the days and weeks following Hurricanes Katrina and Rita in 2005, to better prepare for similar events in the future. Armed with the information and insights provided herein, it is hoped that meaningful precautions and decisive actions can be taken by individuals, families, institutions, communities, and officials should the Louisiana Gulf Coast-or any other area with well-known vulnerabilities-be faced with a future emergency. Demographic and clinical data that were recorded on paper documents during triage and treatment in evacuation shelters were later transcribed into a computerized database management system, with cooperation of the Department of Health Information Management at The University of Louisiana at Lafayette. Analysis of those contemporaneously collected data was undertaken later by the Louisiana Center for Health Informatics. Evacuation shelters, Parish Health Units, and other locations including churches and community centers were the venue for ad hoc clinics in the Acadiana region of Louisiana. The evacuee-patients-3,329 of them-whose information is reflected in the subject dataset were among two geographically distinct but similarly distressed groups: 1) evacuees from Hurricane Katrina that devastated New Orleans and other locales near Louisiana and neighboring states in late August 2005 and 2) evacuees from Hurricane Rita that devastated Southwest Louisiana and neighboring areas of Texas in September 2005. Patient data were collected by physicians, nurses, and other volunteers associated with the Operation Minnesota Lifeline (OML) deployment during the weeks following the events. Volunteer clinicians from OML provided triage and treatment services and documented those services as paper medical records. As the focus of the OML "mission of mercy" was entirely on direct individually

  7. Many Modernities and Utopia : From Thomas More to South Asian Utopian Writings

    NARCIS (Netherlands)

    Bagchi, B.

    2016-01-01

    This chapter sees Utopia as at once a place of dreams, a place of the good, and a place which is nowhere to be found: paradox, ambiguity, and janus-facedness are embedded in a very modern punning coupling of the good, ‘eu’, and the nonexistent, ‘ou’, made by Thomas More in his Greek neologism

  8. Aspectos biológicos e tabela de vida de Uroleucon ambrosiae (Thomas) em função da temperatura

    OpenAIRE

    Auad, Alexander Machado; Moraes, Jair Campos de

    2003-01-01

    The aphid Uroleucon ambrosiae (Thomas) is considered a pest of hidroponically-grown lettuce, but basic and applied information on its control are scarce in Brazil. The aim of this study was to determine the effect of different temperatures on biological aspects and life history of U. ambrosiae (Thomas) developing on hydroponic lettuce (Lactuca sativa L.) crop. Newly emerged nymphs were placed on 4-cm discs of hydroponic lettuce, var. Verônica, which were maintained on 5-cm Petri dishes, at te...

  9. Thomas K. Jeffers: pioneer of coccidiosis research.

    Science.gov (United States)

    Chapman, H D

    2012-01-01

    Thomas K. Jeffers has made many significant contributions to our understanding of the biology of the parasite Eimeria, the cause of coccidiosis in poultry. His work has had direct practical application for the control of this widespread disease. Topics discussed include Jeffers' pioneering work concerned with genetics of the host response to infection, the nature of biological and immunological intraspecific variation, drug resistance and discovery, field surveys of resistance, and his most recognized achievement-the demonstration that the lifecycle of coccidia may be altered by artificial selection. Parasites so modified are attenuated but retain their immunogenicity, a discovery that has led to the development of live vaccines that are inherently non-pathogenic. This article provides a brief biography and describes the contributions that Jeffers has made to our knowledge of coccidiosis.

  10. Numerical studies of the g-hartree density functional in the Thomas-Fermi scaling limit

    International Nuclear Information System (INIS)

    Millack, T.; Weymans, G.

    1986-02-01

    Methods of finite temperature quantum field theory are used to construct the g-Hartree density functional for atoms. Low and high temperature expansions are discussed in detail. Numerical studies for atomic ground-state configurations are presented in the Thomas-Fermi-Scaling limit. (orig.)

  11. Improved thomas formula for radon measurement

    International Nuclear Information System (INIS)

    Ji Changsong

    1991-06-01

    The FT 648 type portable absolute radon meter has been developed and the designing principle of this instrument is introduced. The absolute radon meter differs from relative radon meter. By using structure parameters, operating parameters and readout of this instrument, the radon content of measured gas is obtained directly without calibration in advance. Normally, the calibration is done by a standard radioactive gaseous source of which the radon concentration is known. The systematic error is removed by adding filter-efficiency Σ, α self-absorption correction β, energy spectrum correction S, geometric factor Ω of probe and gravity dropping correction factor G to the Thomas formula for radon measurement of two-filter method. The atmosphere radon content, which is given in hour-average, in Beijing area was measured by FT 648 type absolute radon meter. The measurement lasted continuously for several days and nights and a 'saddle shape' of radon content-time curve was observed. The day's average radon content was 8.5 Bq·m -3

  12. Thomas Walter Bannerman Kibble (1932 - 2016)

    CERN Document Server

    2016-01-01

    Tom Kibble, an internationally-renowned theoretical physicist, passed away on Thursday 2 June.   Tom Kibble in the CMS cavern during a visit to CERN in 2014. (Photo: CMS/CERN) Professor Thomas Walter Bannerman Kibble passed away unexpectedly on 2 June at the age of 83. He was senior research investigator at the Blackett Laboratory and Emeritus Professor of Theoretical Physics at Imperial College, London. He made seminal contributions to our current understanding of symmetries and symmetry breaking in the Standard Model of particle physics. He was among those who, in 1964, proposed the mechanism of spontaneous symmetry breaking in gauge theories, together with G. Guralnik and C. Hagen in the autumn of that year, following the papers by R. Brout and F. Englert and by P. Higgs. When this new understanding was incorporated into a model proposed by S. Glashow in 1961, it led to the first formulations of the Standard Model by S. Weinberg and A. Salam. Kibble deepened our under...

  13. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX

    Science.gov (United States)

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-01-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 – HdmX and Wip1, leading to efficient elimination of tumour cells. PMID:21546907

  14. Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.

    Science.gov (United States)

    Spinnler, C; Hedström, E; Li, H; de Lange, J; Nikulenkov, F; Teunisse, A F A S; Verlaan-de Vries, M; Grinkevich, V; Jochemsen, A G; Selivanova, G

    2011-11-01

    Inactivation of the p53 tumour suppressor, either by mutation or by overexpression of its inhibitors Hdm2 and HdmX is the most frequent event in cancer. Reactivation of p53 by targeting Hdm2 and HdmX is therefore a promising strategy for therapy. However, Hdm2 inhibitors do not prevent inhibition of p53 by HdmX, which impedes p53-mediated apoptosis. Here, we show that p53 reactivation by the small molecule RITA leads to efficient HdmX degradation in tumour cell lines of different origin and in xenograft tumours in vivo. Notably, HdmX degradation occurs selectively in cancer cells, but not in non-transformed cells. We identified the inhibition of the wild-type p53-induced phosphatase 1 (Wip1) as the major mechanism important for full engagement of p53 activity accomplished by restoration of the ataxia telangiectasia mutated (ATM) kinase-signalling cascade, which leads to HdmX degradation. In contrast to previously reported transactivation of Wip1 by p53, we observed p53-dependent repression of Wip1 expression, which disrupts the negative feedback loop conferred by Wip1. Our study reveals that the depletion of both HdmX and Wip1 potentiates cell death due to sustained activation of p53. Thus, RITA is an example of a p53-reactivating drug that not only blocks Hdm2, but also inhibits two important negative regulators of p53 - HdmX and Wip1, leading to efficient elimination of tumour cells.

  15. SOME ASPECTS OF CONTEMPORARY ATHEISM AND ST. THOMAS AQUINA

    Directory of Open Access Journals (Sweden)

    CH. MOREROD

    2010-10-01

    Full Text Available Atheism has become fashionable in the recent years. It has diff erent forms, but in many cases starts from the presupposition that the only rational approach is the one of natural sciences. Believers have the duty to provide some answers to the atheists, also at the philosophical level. St. Thomas Aquinas off ers several arguments that can be explained in contemporary terms: the Universe needs a fi rst cause, which acts also through created causes; our desire for the infi nite is a sign of God; the order of the Universe suggests and organizer

  16. 77 FR 6782 - In the Matter of: Kok Tong Lim, a/k/a Thomas Lim Blk 258A Compassvale Road #07-551 Singapore...

    Science.gov (United States)

    2012-02-09

    ... Thomas Lim Blk 258A Compassvale Road 07-551 Singapore 541258; Order Denying Export Privileges On October...'') of Singapore, pled guilty to one count of violating the International Emergency Economic Powers Act..., a/k/a Thomas Lim, with the last known address at: Blk 258A,Compassvale Road 07-551, Singapore 541258...

  17. NOAA TIFF Graphic- 0.5m Backscatter Mosaic of St. Thomas, US Virgin Islands, 2004

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This image represents a 0.5 meter resolution backscatter mosaic of the south shore of St. Thomas, US Virgin Islands.NOAA's NOS/NCCOS/CCMA Biogeography Team and...

  18. Thomas Aquinas on the Beatitudes : Reading Matthew, Disputing Grace and Virtue, Preaching Happiness

    NARCIS (Netherlands)

    ten Klooster, Anton

    2018-01-01

    What is happiness and how do we attain it? Saint Thomas Aquinas (ca. 1226-1274) devoted much time to these questions. In studying them he always returned to the beatitudes as they are found in Matthew 5:1-10. They function as the framework for his theology of human happiness. This study presents

  19. The Two Hands of Thomas Aquinas : The Reportationes of the Commentary on Matthew

    NARCIS (Netherlands)

    ten Klooster, Anton

    2014-01-01

    The gospel of Matthew is more important to the theology of Thomas Aquinas than most scholars have realised. Access to his commentary on this gospel is impeded by the lack of a critical edition. Moreover, we have only two reportationes of the text. In order to establish the value of these texts, I

  20. Thomas Mann's Death in Venice or Plutarch's way towards Eros

    OpenAIRE

    Gilabert Barberà, Pau

    2010-01-01

    In Death in Venice Thomas Mann refers explicitly to Plato's Symposium and Phaedrus in order to explain the relationship between Gustav von Aschenbach and Tadzio but he hides that his novel also depends on Plutarch's Eroticus. Why? The aim of this article is precisely to reveal the different reasons for such an attitude. Indeed, Plutarch speaks highly of conjugal love in his Eroticus and this way is not followed by Mann in Death in Venice but, at the same, the German writer finds in this Pluta...

  1. "German Culture is where I am": Thomas Mann in Exile

    OpenAIRE

    Helmut Koopmann

    1982-01-01

    Thomas Mann in exile reacted like many writers expelled from Germany: totally irritated he tried to defend his own identity by claiming that he was still the leading representative of Germany. But about 1938 a process of dissociation from Germany started which led to sharp remarks on Germany in his The Beloved Returns , to his conviction that German culture was where he lived and to the acknowledgement of America as his new home. Traces of his experience of exile, and a late answer on his se...

  2. Florística em um hectare de cerrado stricto sensu na ARIE - cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, SP

    OpenAIRE

    Weiser, Veridiana de Lara; Godoy, Silvana Aparecida Pires de

    2001-01-01

    Foi realizado um levantamento florístico em um ha de cerrado stricto sensu, na parte norte da ARIE - Cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, São Paulo. Foram coletados 428 espécimes em fase reprodutiva, em vinte e cinco excursões de coleta, durante o período de novembro de 1996 a abril de 1998. A listagem florística obtida apresenta 141 espécies, distribuídas em 109 gêneros e 49 famílias. As famílias mais representativas foram: Leguminosae, Asteraceae, Malpighiaceae e Myrtaceae. A ...

  3. Bathymetry 1m GRID of St. Thomas, US Virgin Islands, 2004, UTM 20 WGS84

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains an ESRI Grid with 1 meter cell size representing the bathymetry of the south shore of St. Thomas, US Virgin Islands. NOAA's NOS/NCCOS/CCMA...

  4. Thomas J. Ahrens (1936-2010)

    Science.gov (United States)

    Jeanloz, Raymond

    2011-03-01

    Thomas J. Ahrens, a leader in the study of high-pressure shock wave and planetary impact phenomena, died at his home in Pasadena, Calif., on 24 November 2010 at the age of 74. He was the California Institute of Technology's Fletcher Jones Professor of Geophysics, emeritus since 2005 but professionally active to the end. He had been president of AGU's Tectonophysics section, editor of Journal of Geophysical Research, founding member of both the Mineral and Rock Physics and Study of the Earth's Deep Interior focus groups, and editor—more like key driving force—for AGU's Handbook of Physical Constants. Tom was a pioneer in experimental and numerical studies of the effects of projectiles hitting a target at velocities exceeding the speed of sound (hypervelocity impact), arguably the most important geophysical process in the formation, growth, and, in many cases, surface evolution of planets. As a professor at Caltech, he established the foremost university laboratory for shock wave experiments, where students and research associates from around the world pursued basic research in geophysics, planetary science, and other disciplines. Previously, high-pressure shock experiments were conducted primarily in national laboratories, where they were initially associated with the development of nuclear weapons.

  5. Thomas Edison’s Poetry Machine

    Directory of Open Access Journals (Sweden)

    Matthew Rubery

    2014-04-01

    Full Text Available The tradition of spoken-word recording began with Thomas Edison’s invention of the phonograph. Hence, this article makes the case that 1878 is a more important year to the history of literature than has yet been recognized for its experiments with verse and sound-recording technology. Although the tinfoil phonograph’s first decade has been well documented by media historians, literary critics have singled out 1888 as the noteworthy year since that is when Edison’s improved phonograph made it possible to record prominent figures including Alfred Tennyson and Robert Browning. Taking Edison’s original tinfoil phonograph as an alternative starting point reveals how the 1878 phonograph demonstrations, despite technological limitations, undertook acoustic experiments that enabled audiences to discern new forms of meaning, pleasure, and pathos in even the most well-known material. The recordings considered here include ‘Mary Had a Little Lamb’ as well as scripts by Tennyson, Caroline Norton, Edgar Allan Poe, Shakespeare, and others. Such recitals illustrate the extent to which Edison’s talking machine influenced the reception of texts while at the same time giving rise to performances unheard of in previous cultures.

  6. The Nuclear Thomas-Fermi Model

    Science.gov (United States)

    Myers, W. D.; Swiatecki, W. J.

    1994-08-01

    The statistical Thomas-Fermi model is applied to a comprehensive survey of macroscopic nuclear properties. The model uses a Seyler-Blanchard effective nucleon-nucleon interaction, generalized by the addition of one momentum-dependent and one density-dependent term. The adjustable parameters of the interaction were fitted to shell-corrected masses of 1654 nuclei, to the diffuseness of the nuclear surface and to the measured depths of the optical model potential. With these parameters nuclear sizes are well reproduced, and only relatively minor deviations between measured and calculated fission barriers of 36 nuclei are found. The model determines the principal bulk and surface properties of nuclear matter and provides estimates for the more subtle, Droplet Model, properties. The predicted energy vs density relation for neutron matter is in striking correspondence with the 1981 theoretical estimate of Friedman and Pandharipande. Other extreme situations to which the model is applied are a study of Sn isotopes from {sup 82}Sn to {sup 170}Sn, and the rupture into a bubble configuration of a nucleus (constrained to spherical symmetry) which takes place when Z{sup 2}/A exceeds about 100.

  7. Nephrologic Impact of Hurricanes Katrina and Rita in Areas Not Directly Affected.

    Science.gov (United States)

    Dossabhoy, Neville R; Qadri, Mashood; Beal, Lauren M

    2015-01-01

    Hurricanes Katrina and Rita resulted in enormous loss of life and disrupted the delivery of health care in areas affected by them. In causing mass movements of patients, natural disasters can overwhelm the resources of nephrology communities in areas not suffering direct damage. The following largely personal account evaluates the impact these hurricanes had upon the nephrology community, patients and health care providers alike, in areas not directly affected by the storms. Mass evacuation of hundreds of dialysis patients to surrounding areas overwhelmed the capacity of local hemodialysis centers. Non-availability of medical records in patients arriving without a supply of their routine medications led to confusion and sub-optimal treatment of conditions such as hypertension and congestive heart failure. Availability of cadaveric organs for transplantation was reduced in the surrounding areas, as the usual lines of communication and transportation were severed for several weeks. All of these issues led to prolong waiting times for patients on the transplant list. The hurricanes severely disrupted usual supply lines of medications to hospitals; certain rare conditions may be seen in higher numbers as a result of the shortages induced. We present the interesting surge in cases of acute kidney injury secondary to use of intravenous immune globulin.

  8. Changes in microbial community structure in the wake of Hurricanes Katrina and Rita.

    Science.gov (United States)

    Amaral-Zettler, Linda A; Rocca, Jennifer D; Lamontagne, Michael G; Dennett, Mark R; Gast, Rebecca J

    2008-12-15

    Hurricanes have the potential to alter the structures of coastal ecosystems and generate pathogen-laden floodwaters thatthreaten public health. To examine the impact of hurricanes on urban systems, we compared microbial community structures in samples collected after Hurricane Katrina and before and after Hurricane Rita. We extracted environmental DNA and sequenced small-subunit rRNA (SSU rRNA) gene clone libraries to survey microbial communities in floodwater, water, and sediment samples collected from Lake Charles, Lake Pontchartrain, the 17th Street and Industrial Canals in New Orleans, and raw sewage. Correspondence analysis showed that microbial communities associated with sediments formed one cluster while communities associated with lake and Industrial Canal water formed a second. Communities associated with water from the 17th Street Canal and floodwaters collected in New Orleans showed similarity to communities in raw sewage and contained a number of sequences associated with possible pathogenic microbes. This suggests that a distinct microbial community developed in floodwaters following Hurricane Katrina and that microbial community structures as a whole might be sensitive indicators of ecosystem health and serve as "sentinels" of water quality in the environment.

  9. The Santa Rita Shear Zone: Major Mesozoic deformation along the western flank of the White-Inyo Range, CA

    Energy Technology Data Exchange (ETDEWEB)

    Brudos, T.C.; Paterson, S.R. (Univ. of Southern California, Los Angeles, CA (United States). Dept. of Geological Sciences)

    1993-04-01

    The Santa Rita Shear Zone (SRSZ), briefly described by Ross (1967), deforms the western part of the 164 Ma Santa Rita Flat pluton (SRFP), located SSE of Big Pine, CA. The SRSZ comprises a subvertical zone of solid-state deformation (strike N15E) over an area at least 13 km long by 2--3 km wide. Exposure of the shear zone is limited to the north and west by overlying Quaternary volcanics and basin fill within the Late Cenozoic Owens Valley graben. The SRSZ is larger than its present outcrop extent: strain magnitudes are highest within the westernmost exposures. The SRSZ along this western margin is a continuous zone of deformation comprising a mm-scale solid-state foliation containing igneous feldspars flattened into ovals with > 10:1 aspect ratios. The authors have identified three dike phases within the SRFP: (1) minor NE-striking Phase 1 dikes, comprising cm-scale aplites; (2) widespread m-scale Phase 2 dikes, which strike N10E; and (3) m-scale NW-striking Phase 3 mafic dikes. The Phase 1 and Phase 3 dikes are pre- and post-tectonic respectively; observations described below indicate the Phase 2 dikes are syn- to post-deformation. Deformation becomes localized along the Phase 2 dikes -- which are parallel to the orientation of the main body of the shear zone. Solid-state fabrics imposed on the Phase 2 dikes formed at higher temperatures than those within the SRFP, and in the east the SRFP is deformed only within a few cm of the dikes. They surmise syntectonic emplacement of the dikes into dislocational surfaces within the SRSZ, followed by solid-state deformation of the cooling dikes. Several workers have suggested the dikes within the SRFP are part of the 148 Ma independence dike swarm (referring to the Phase 2 or 3 dikes). If correct, this correlation indicates a Jurassic age for the SRSZ. Radiometric analyses of the dikes are in progress.

  10. Application of the Thomas-Fermi statistical model to the thermodynamics of high density matter; Aplicacion del modelo estadistico de Thomas-Fermi a la termodinamica de medios ultradensos

    Energy Technology Data Exchange (ETDEWEB)

    Martin, R

    1977-07-01

    The Thomas-Fermi statistical model, from the N-body point of view is used in order to have systematic corrections to the T-Fermis equation. Approximate calculus methods are found from analytic study of the T-Fermis equation for non zero temperature. T-Fermis equation is solved with the code GOLEM written in FORTRAN V (UNIVAC). It also provides the thermodynamical quantities and a new method to calculate several isothermal tables. (Author) 24 refs.

  11. Dualling Thomas: Maine College Helps Students Earn College Credit While in High School

    Science.gov (United States)

    MacKenzie, Riley

    2016-01-01

    The Pathways Program allows juniors and seniors in high school who have a high school GPA of 3.0, a demonstrated capacity for college work, and a recommendation of the high school guidance counselor, to pursue their associate degrees at Thomas College in Waterville, Maine, while completing the requirements for their high school diploma at…

  12. From pioneering to implementing automated blood pressure measurement in clinical practice: Thomas Pickering's legacy

    DEFF Research Database (Denmark)

    Stolarz-Skrzypek, Katarzyna; Thijs, Lutgarde; Wizner, Barbara

    2010-01-01

    Thomas G. Pickering spent most of his scientific career in carrying out research on clinical hypertension and blood pressure (BP) measurement. In our review of Pickering's seminal work, we first focused on white-coat hypertension and masked hypertension, two terms that he had introduced. Next, we...

  13. Lübecki filmipäevad 1999 ja Thomas Manni ekraniseering 1923 / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    1999-01-01

    4.-7. novembrini Lübeckis toimunud Põhjamaade filmipäevade 41. Nordische Filmtage huvitavamatest filmidest, nagu Thomas Manni "Buddenbrookide" ekraniseering 1923. aastast (režissöör Gerhard Lamprecht) ja Rasmus Gerlachi dokumentaal "Operaator Kaufman" Dziga Vertovist ja tema kahest, samuti kino alal tegutsenud vennast

  14. Dalit humanization: A Quest based on M.M. Thomas' theology of salvation and humanization

    NARCIS (Netherlands)

    Rajaiah, J.

    2016-01-01

    Chapter one states the central quest of this thesis: to develop a Dalit theology on the basis of the concepts salvation and humanization of M.M. Thomas. Chapter two elucidates the socio- political and religious milieu which influenced his theology. Thomas’ theology has evolved and developed in

  15. Wind Power Opportunities in St. Thomas, USVI: A Site-Specific Evaluation and Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, E.; Warren, A.; Roberts, J. O.; Gevorgian, V.

    2012-09-01

    This NREL technical report utilizes a development framework originated by NREL and known by the acronym SROPTTC to assist the U.S. Virgin Islands in identifying and understanding concrete opportunities for wind power development in the territory. The report covers each of the seven components of the SROPTTC framework: Site, Resource, Off-take, Permitting, Technology, Team, and Capital as they apply to wind power in the USVI and specifically to a site in Bovoni, St. Thomas. The report concludes that Bovoni peninsula is a strong candidate for utility-scale wind generation in the territory. It represents a reasonable compromise in terms of wind resource, distance from residences, and developable terrain. Hurricane risk and variable terrain on the peninsula and on potential equipment transport routes add technical and logistical challenges but do not appear to represent insurmountable barriers. In addition, integration of wind power into the St. Thomas power system will present operational challenges, but based on experience in other islanded power systems, there are reasonable solutions for addressing these challenges.

  16. Globe Event | Lecture by Hervé Dessimoz and Thomas Büchi | 14 May

    CERN Document Server

    Globe Info

    2013-01-01

    At the summit of Sustainable Development, by Hervé Dessimoz and Thomas Büchi.   Globe de la science et de l'innovation Route de Meyrin, 1211 Genève Tuesday 14 May 2013 at 8:30 p.m. The lecture will be in French Refuge du Goûter. Hervé Dessimoz and Thomas Büchi have been committed to sustainable development since the 2000s. They created the Palais de l’Équilibre at Expo.02. They designed an exhibition in conjunction with the Cité de la Science et de l’Industrie (Paris) to educate visitors about sustainable development. The pavilion was donated to CERN by the Swiss Confederation and rebuilt on the CERN site in 2004. It is now known as the Globe of Science and Innovation. The Refuge du Goûter, on the slopes of Mont Blanc, is the culmination of their research into sustainable development, with the aim of demonstrating that if we can construct a building at 3835 m which is a...

  17. GUERRA E PAZ NA TEORIA POLÍTICA DE THOMAS HOBBES

    Directory of Open Access Journals (Sweden)

    Lígia Pavan Baptista

    2014-08-01

    Full Text Available Este artigo tem o objetivo de analisar em que medida a teoria política moderna, tal como apresentada por Thomas Hobbes, expondo um novo paradigma na análise de questões como a origem do Estado e do poder político, assim como, definindo, por meio de metodologia científica, conceitos tais como guerra, paz, soberania, justiça, igualdade e liberdade, podem estabelecer as raízes de questões das relações internacionais, apesar de não ser o principal objetivo do autor.

  18. Floristic composition of the cerrado in the Pé-de-Gigante Reserve (Santa Rita do Passa Quatro, southeastern Brazil Composição florística do cerrado na Reserva Pé-de-Gigante (Santa Rita do Passa Quatro, SP

    Directory of Open Access Journals (Sweden)

    Marco Antônio Batalha

    2001-12-01

    Full Text Available We studied a 1225 ha area, composed mainly of cerrado, in Santa Rita do Passa Quatro, São Paulo State, southeastern Brazil (21°36-38'S, 47°36-39'W. In three cerrado physiognomies (campo cerrado -- a wooded savanna, cerrado sensu stricto -- a woodland, and cerradão -- a tall woodland, we collected all vascular plants in reproductive stage, and identified them to species level. We found 360 species, representing 236 genera and 69 families. The richest families were: Asteraceae, Fabaceae, Poaceae, and Rubiaceae. The savanna physiognomies were richer than the forest one. The ratio between herbaceous and woody species was approximately 2:1. We analysed the whole flora and its two components separately, woody and herbaceous, comparing them with other disjunct cerrado areas. We obtained similarity values (Sørensen index from 0.47 to 0.81, which showed that the 3 diversity of the cerrado was higher in the herbaceous component than in the woody one.Estudamos uma área de 1225 ha, composta principalmente por cerrado, situada em Santa Rita do Passa Quatro, estado de São Paulo (21°36-38'S, 47°36-39'W. Em três fisionomias de cerrado (campo cerrado, cerrado sensu stricto e cerradão, coletamos, durante 18 meses, em excursões mensais, espécimes em fase fértil e os identificamos em nível específico. Encontramos 360 espécies, pertencentes a 236 gêneros e 69 famílias. As fam��lias mais ricas foram: Fabaceae, Asteraceae, Poaceae e Rubiaceae. As fisionomias savânicas foram mais ricas do que a florestal. A razão entre espécies arbustivo-arbóreas e herbáceo-subarbustivas foi de aproximadamente 2:1. Analisamos a flora como um todo e seus componentes herbáceo-subarbustivo e arbustivo-arbóreo separadamente, comparando-os com outras áreas disjuntas de cerrado. Dessa comparação, obtivemos valores de similaridade (índice de Sørensen de 0,47 a 0,81, que mostraram que a diversidade 3 foi maior no componente herbáceo-subarbustivo do que no

  19. The non-intuitive 1/2 Thomas factor: a heuristic argument with classical electromagnetism

    International Nuclear Information System (INIS)

    Chrysos, M

    2006-01-01

    We present a heuristic argument to deduce the non-intuitive 1/2 Thomas factor for an atomic electron revolving in its orbit about the nucleus. The argument, which is simple, pedagogical and accessible to physics beginners, uses elementary notions of classical electromagnetism rather than the advanced relativity concepts which are needed in any standard textbook derivation

  20. Briti teadlane: kübersõda ei tule / Thomas Rid ; intervjueerinud Raimo Poom

    Index Scriptorium Estoniae

    Rid, Thomas

    2013-01-01

    Sõjauuringute õppejõud Thomas Rid leiab, et internetis on palju ohte, kuid kübersõda ei ole üks neist. Ridi arvates on äärmiselt ebatõenäoline, et NATO käivitaks kunagi küberrünnaku tõttu 5. artikli. Interneti kõige suuremaks ohustajaks pole NSA, vaid vabadust piirata soovivad autoritaarsed riigid

  1. The Reverend Thomas Jefferson Bowen: An Introductory Background to His Linguistic Works, 1850-1856

    Science.gov (United States)

    Awoniyi, Timothy A.

    1974-01-01

    A historical narrative background for the linguistic works of Thomas Jefferson Bowen, an American missionary who was the first non-Nigerian to publish a grammar of Yoruba (1858). The author points up a need for further scholarly review of Bowen's pioneering work and contribution to Yoruba studies. (JT)

  2. Molecular characterization and experimental host range of an isolate of Wissadula golden mosaic St. Thomas virus.

    Science.gov (United States)

    Collins, A M; Mujaddad-ur-Rehman, Malik; Brown, J K; Reddy, C; Wang, A; Fondong, V; Roye, M E

    2009-12-01

    Partial genome segments of a begomovirus were previously amplified from Wissadula amplissima exhibiting yellow-mosaic and leaf-curl symptoms in the parish of St. Thomas, Jamaica and this isolate assigned to a tentative begomovirus species, Wissadula golden mosaic St. Thomas virus. To clone the complete genome of this isolate of Wissadula golden mosaic St. Thomas virus, abutting primers were designed to PCR amplify its full-length DNA-A and DNA-B components. Sequence analysis of the complete begomovirus genome obtained, confirmed that it belongs to a distinct begomovirus species and this isolate was named Wissadula golden mosaic St. Thomas virus-[Jamaica:Albion:2005] (WGMSTV-[JM:Alb:05]). The genome of WGMSTV-[JM:Alb:05] is organized similar to that of other bipartite Western Hemisphere begomoviruses. Phylogenetic analyses placed the genome components of WGMSTV-[JM:Alb:05] in the Abutilon mosaic virus clade and showed that the DNA-A component is most closely related to four begomovirus species from Cuba, Tobacco leaf curl Cuba virus, Tobacco leaf rugose virus, Tobacco mottle leaf curl virus, and Tomato yellow distortion leaf virus. The putative Rep-binding-site motif in the common region of WGMSTV-[JM:Alb:05] was observed to be identical to that of Chino del tomate virus-Tomato [Mexico:Sinaloa:1983], Sida yellow mosaic Yucatan virus-[Mexico:Yucatan:2005], and Tomato leaf curl Sinaloa virus-[Nicaragua:Santa Lucia], suggesting that WGMSTV-[JM:Alb:05] is capable of forming viable pseudo-recombinants with these begomoviruses, but not with other members of the Abutilon mosaic virus clade. Biolistic inoculation of test plant species with partial dimers of the WGMSTV-[JM:Alb:05] DNA-A and DNA-B components showed that the virus was infectious to Nicotiana benthamiana and W. amplissima and the cultivated species Phaseolus vulgaris (kidney bean) and Lycopersicon esculentum (tomato). Infected W. amplissima plants developed symptoms similar to symptoms observed under field

  3. Las revoluciones de Thomas Kuhn, una mirada discontinuista

    Directory of Open Access Journals (Sweden)

    Pablo Melogno

    Full Text Available Resumen Se discuten algunas divergencias entre La revolución copernicana (1957 y La estructura de las revoluciones científicas (1962, de Thomas Kuhn. Se muestra que presentan una consideración diferente de los factores extracientíficos, que tienen en la primera un peso explicativo mayor. Se propone que en 1957 Kuhn maneja una historiografía casuística, centrada en la revolución copernicana, y en 1962 una historiografía estructural, centrada en los rasgos invariantes de las revoluciones científicas. Se concluye que las diferencias entre las dos obras son lo suficientemente profundas como para no considerarlas expresión de una misma visión de la ciencia.

  4. Status of Thomas Jefferson National Accelerator Facility (Jefferson Lab)

    International Nuclear Information System (INIS)

    H.A. Grunder

    1997-01-01

    When first beam was delivered on target in July 1994, the Continuous Electron Beam Accelerator Facility (CEBAF), in Newport News, Virginia realized the return on years of planning and work to create a laboratory devoted to exploration of matter that interacts through the strong force, which holds the quarks inside the proton and binds protons and neutrons into the nucleus. Dedicated this year as the Thomas Jefferson National Accelerator Facility (Jefferson Lab), the completion of construction and beginning of its experimental program has culminated a process that began more than a decade ago with the convening of the Bromley Panel to look at research possibilities for such an electron accelerator

  5. Thomas James Walker (1835-1916): Surgeon and general practitioner.

    Science.gov (United States)

    Thomas, Martyn

    2018-02-01

    Thomas James Walker was a surgeon and general practitioner who worked in the city of Peterborough at a time when there were changes and innovations in the practice of medicine. After training in medicine and surgery at Edinburgh University, he qualified in London in 1857. He was a pioneer of laryngoscopy. He played an important role in introducing antiseptic surgery to the Peterborough Infirmary and was instrumental in the development of the operating theatre which opened in 1894. He was a philanthropist and collector of Roman and Saxon artefacts. In 1915, he was recognized as an outstanding member of the Peterborough community when he was offered the Freedom of the City.

  6. Św.Tomasza z Akwinu charakterystyka aktów woli / The Acts of the Will According to St. Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Hubert Wiśniewski

    2015-06-01

    Full Text Available The article attempts to clarify an important aspect of St. Thomas Aquinas’s theory of human action, namely to show these acts of man which are immediately caused by the will. According to some contemporary philosophers, the acts of the will are limited to those of trying or of intending. Do they exhaust the whole possibility of the will to act? The author seeks to answer this question basing his considerations on the analysis of the Summa Theologiae by St. Thomas Aquinas.

  7. 78 FR 65511 - Death of Thomas S. Foley Former Speaker of the House of Representatives

    Science.gov (United States)

    2013-10-31

    ... Vol. 78 Thursday, No. 211 October 31, 2013 Part IV The President Proclamation 9046--Death of Thomas S. Foley Former Speaker of the House of Representatives #0; #0; #0; Presidential Documents #0; #0...; #0; #0;Title 3-- #0;The President [[Page 65513

  8. Spherical time dependent Thomas-Fermi calculation of the dynamical evolution of hot and compressed nuclei

    International Nuclear Information System (INIS)

    Nemeth, J.; Barranco, M.; Ngo, C.; Tomasi, E.

    1985-01-01

    We have used a self-consistent time dependent Thomas-Fermi model at finite temperature to calculate the dynamical evolution of hot and compressed nuclei. It has been found that nuclei can accomodate more thermal energy than compressional energy before they break. (orig.)

  9. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  10. Play as a Basic Pathway to the Self: An Interview with Thomas S. Henricks

    Science.gov (United States)

    American Journal of Play, 2015

    2015-01-01

    Thomas S. Henricks is the J. Earl Danieley Professor of Sociology and Distinguished University Professor at Elon University. Since receiving his doctorate in sociology at the University of Chicago, Henricks has investigated the sociology of sports from the fandom of modern American professional wrestling to the relationship between sports and…

  11. WATER TEMPERATURE and Other Data from THOMAS G. THOMPSON from 19920323 to 19921020 (NODC Accession 9700194)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Oxygen production, abundance of marine snow, and other data were collected from bottle and video camera casts in the Pacific Ocean from the THOMAS G. THOMPSON from...

  12. Thomas Albrecht, The Medusa Effect: Representation and Epistemology in Victorian Aesthetics

    OpenAIRE

    Sauvage, Julie

    2016-01-01

    Thomas Albrecht presents a stimulating study of what he calls the “Medusa effect” in Victorian aesthetics. This specific pattern, linked to the mythological figure of Medusa, raises both epistemological and aesthetic issues. The wide range of texts he examines spans a variety of genres and includes works by Gabriel Dante Rosetti, Freud, Nietzsche, Swinburne and Pater as well as George Eliot. They may not all be Victorian in the strict sense, but T. Albrecht does convincingly show that they al...

  13. Efimov effect, Thomas effect and model dependence of three-particle observables

    International Nuclear Information System (INIS)

    Adhikari, S.K.; Delfino, A.; Frederico, T.; Goldman, I.D.; Tomio, L.

    1987-01-01

    It is demonstrated for the three-dimensional three-particle system that a divergence arising from essentially the same singularity structure of the Kernel of the scattering integral equation is responsible for both the Efimov and Thomas effects. The above divergence implies that the results of three-particle dynamical calculation be sensitive to the details of the two-particle interaction. In two-dimensional systems the above divergence is absent and consequently the three-particle observables become essentially model independent. (M.W.O.) [pt

  14. Physician/chemist/geologist: Charles Thomas Jackson's life of conflict and controversy

    Science.gov (United States)

    Landa, E.R.

    1995-01-01

    After a brief medical career, Charles Thomas Jackson (1805-1880) began work as a consulting chemist and geologist in Boston. He serves as State Geologist in Maine, Rhode Island, and New Hampshire from 1837 to 1884, and completed geological surveys of those States. In 1847, he was appointed United States Geologist to undertake a survey of the public lands of the Lake Superior region of Michigan. This survey was beset by strife, and Jackson was forced to resign in 1849. -from Author

  15. Multicenter Phase II Study with Weekly Bendamustine and Paclitaxel as First- or Later-Line Therapy in Patients with Metastatic Breast Cancer: RiTa II Trial.

    Science.gov (United States)

    Loibl, Sibylle; Doering, Gabriele; Müller, Lothar; Grote-Metke, Albert; Müller, Roberto; Tomé, Oliver; Wiest, Wolfgang; Maisch, Andrea; Nekljudova, Valentina; von Minckwitz, Gunter

    2011-12-01

    The combination of bendamustine (B) and paclitaxel (P) as anthracycline-free treatment option in patients with advanced breast cancer has been evaluated in the previous RiTa I trial. The regimen of weekly B 70 mg/m(2) and P 90 mg/m(2) with a pause every 4th week was established as an effective regimen with low toxicity. The aim of the present RiTa II study was to investigate the potential of BP as anthracycline-free combination therapy. The primary objective was to determine the progression-free survival (PFS); secondary endpoints were safety, tolerability, overall response rate (ORR) and overall survival (OS). 26 patients were available, 15 received BP as first-line, 11 as beyond first-line treatment. 27% patients had triple-negative breast cancer (TNBC). Median PFS and OS were 7.3 months (95% confidence interval (CI): 5.5-10.9) and 14.9 months (95% CI: 9.9-22.9), respectively. The 1-year PFS rate was 20.3% and the 1-year OS rate 71.2%. The ORR was 42.3%, including 4 complete and 7 partial remissions. TNBC patients reached an ORR of 71.4%. Anthracycline-pretreated patients showed an ORR of 43.8%, confirming bendamustine's lack of cross-resistance to anthracycline agents. BP represents a favorable option with moderate toxicity in pretreated metastatic breast cancer and offers a possibility for application in anthracycline-pretreated and TNBC patients.

  16. Thomas Merton Goes to Class: Pedagogy on the Borders of the Short Story

    Science.gov (United States)

    Callaghan, Michael J.

    2011-01-01

    Our thesis is more finely tuned to Thomas Merton (1915-68) the writer, more specifically, the poet/artist/writer and thinker. These are the components of the "Merton" voice. Merton senses the quality of innocence as the "sine qua non" of the poet or writer's vocation: "His art depends on an ingrained innocence which he would lose in business, in…

  17. A Nobel Prize for empirical macroeconometrics: assessing the contributions of Thomas Sargent and Christopher Sims

    NARCIS (Netherlands)

    Boumans, M.; Sent, E.M.

    2013-01-01

    This paper provides an assessment of the contributions of the 2011 Nobel Prize winners, Thomas Sargent and Christopher Sims. They received the prize ‘for their empirical research on cause and effect in the macroeconomy’. The paper illustrates that Sargent entertained different interpretations of

  18. Effects of age on long-term outcomes after a routine invasive or selective invasive strategy in patients presenting with non-ST segment elevation acute coronary syndromes: a collaborative analysis of individual data from the FRISC II - ICTUS - RITA-3 (FIR) trials.

    Science.gov (United States)

    Damman, Peter; Clayton, Tim; Wallentin, Lars; Lagerqvist, Bo; Fox, Keith A A; Hirsch, Alexander; Windhausen, Fons; Swahn, Eva; Pocock, Stuart J; Tijssen, Jan G P; de Winter, Robbert J

    2012-02-01

    To perform a patient-pooled analysis of a routine invasive versus a selective invasive strategy in elderly patients with non-ST segment elevation acute coronary syndrome. A meta-analysis was performed of patient-pooled data from the FRISC II-ICTUS-RITA-3 (FIR) studies. (Un)adjusted HRs were calculated by Cox regression, with adjustments for variables associated with age and outcomes. The main outcome was 5-year cardiovascular death or myocardial infarction (MI) following routine invasive versus selective invasive management. Regarding the 5-year composite of cardiovascular death or MI, the routine invasive strategy was associated with a lower hazard in patients aged 65-74 years (HR 0.72, 95% CI 0.58 to 0.90) and those aged ≥75 years (HR 0.71, 95% CI 0.55 to 0.91), but not in those aged RITA-3).

  19. Ethics in the medieval university: the importance of classics reading for the elaboration of Thomas Aquinas

    Directory of Open Access Journals (Sweden)

    Tatyana Murer Cavalcante

    2012-05-01

    Full Text Available This paper aims to present some considerations about the importance of reading to the development of the ethics conceptions of Thomas Aquinas (1224 - 5? / 1274. At the dawn of the thirteenth century, the townspeople of Medieval West created a new institution designed for knowledge and education: the University. In it, teachers and disciples were debating key issues for the new society using mainly texts of Ancient Philosophy and Christians, but also Arab and Jewish writings. The literacy forms used encompassed mainly lectio and disputatio , and counteracted by distinct theoretical bases, those thinkers eventually recreated the summa , in a original and fundamental form to the philosophical elaboration of that time. To discuss the importance of reading in the formulation of the concept of ethics in the medieval university, we will present some characteristics of the production of knowledge in the thirteenth century linked to its historical context and then discuss some ethical considerations of Thomas Aquinas, one of the most prominent authors of that period. Considering the limits of this article, only one text, “The object of charity” based on Aquinas major work, the Summa of Theology, will be discussed in depth. Preliminarily, it is possible to state that as well as the reading of classical authors by Thomas Aquinas and other masters of the thirteenth century, helped them develop knowledge about ethics conforming to their time, historical reading of these authors helps in the understanding of today.

  20. Nutrients, sedimentation and total suspended solids in the St. Thomas East End Reserves in the Caribbean Sea from 2012-01-16 to 2013-11-25 (NCEI Accession 0139480)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains the results from monitoring in the St. Thomas East End Reserves (STEER) in St. Thomas, USVI, from January 2012 to November 2013. The...