Risperidone-related reversal of primary enuresis: an unusual case report.

Science.gov (United States)

Mendhekar, D N; Andrade, C

2010-03-01

Occasional reports have documented treatment-emergent enuresis with medication regimens that include risperidone. In contrast to these reports, we present a 12-year-old girl with mild mental retardation and primary nocturnal enuresis who received risperidone (0.5 mg/day) for the isolated symptom of inappropriate smiling. Surprisingly, in addition to reduction in inappropriate smiling, risperidone also substantially decreased the frequency of enuresis. These benefits with risperidone were confirmed in an on-off-on treatment sequence. To our knowledge, this is the first case in literature of primary enuresis responding to low-dose risperidone. Low-dose risperidone may merit study in children with enuresis. Clinical implications and possible mechanisms are discussed.

Postmortem Femoral Blood Concentrations of Risperidone

DEFF Research Database (Denmark)

Linnet, Kristian; Johansen, Sys Stybe

2014-01-01

Postmortem femoral blood concentrations of the antipsychotic drug risperidone and the active metabolite 9-hydroxyrisperidone were determined by an achiral LC-MS/MS method in 38 cases. The cause of death was classified as unrelated to risperidone in 30 cases, in which the sum of the concentration ...

Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.

Science.gov (United States)

Rogóż, Zofia; Kabziński, Marcin; Sadaj, Witold; Rachwalska, Paulina; Gądek-Michalska, Anna

2012-01-01

Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression. The present study aimed to examine the effect of treatment with fluoxetine or mirtazapine, given separately or jointly with risperidone, on active behavior and plasma corticosterone level in male Wistar rats subjected to the forced swim test (FST). The obtained results showed that fluoxetine (5 mg/kg), mirtazapine (5 and 10 mg/kg) or risperidone (0.05 and 0.1 mg/kg) did not change the active behavior of rats in the FST. However, co-treatment with fluoxetine (10 mg/kg) and risperidone (0.1 mg/kg) induced an antidepressant-like effect in that test because it significantly increased the swimming time and decreased the immobility time, while combined treatment with mirtazapine at 5 and 10 mg/kg and risperidone at 0.05 and 0.1 mg/kg evoked a significant increase in the swimming time and also climbing, and decreased the immobility time. WAY 100635 (a 5-HT(1A) receptor antagonist) at a dose of 0.1 mg/kg inhibited the antidepressant-like effect induced by co-administration of fluoxetine or mirtazapine and risperidone. Active behavior in that test did not reflect an increase in general activity, since combined treatment with fluoxetine or mirtazapine and risperidone failed to enhance the exploratory activity of rats. Co-treatment with fluoxetine or mirtazapine and risperidone did not reduce the stress-induced increase in plasma corticosterone concentration in animals subjected to the FST. The obtained results indicate that risperidone applied in a low dose enhances the antidepressant-like activity of fluoxetine and mirtazapine in the FST (but does not normalize the stress-induced increase in corticosterone level in these rats), and that 5-HT(1A) receptors may play some role in these effects.

Enhancement of the anti-immobility action of antidepressants by risperidone in the forced swimming test in mice.

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Rogóż, Zofia; Kabziński, Marcin

2011-01-01

The aim of the present study was to examine the effect of antidepressants (ADs) belonging to different pharmacological groups and risperidone (an atypical antipsychotic drug), given separately or jointly, on immobility time in the forced swimming test in male C57BL/6J mice. The antidepressants: citalopram, fluvoxamine, sertraline, reboxetine, milnacipran (5 and 10 mg/kg), or risperidone in low doses (0.05 and 0.1 mg/kg) given alone did not change the immobility time of mice in the forced swimming test. Co-treatment with reboxetine or milnacipran (10 mg/kg) and risperidone in a lower dose of 0.05 mg/kg or with sertraline, reboxetine (5 and 10 mg/kg), citalopram, fluvoxamine, milnacipran (10 mg/kg) and risperidone in a higher dose of 0.1 mg/kg produced antidepressant-like effect in the forced swimming test. WAY100635 (a 5-HT(1A) receptor antagonist) inhibited the effects induced by co-administration of ADs and risperidone. Active behavior in the forced swimming test was not a consequence of an increased general activity, since the combined treatment with ADs and risperidone failed to enhance the locomotor activity of mice. The obtained results indicate that a low dose of risperidone enhances the activity of ADs in an animal model of depression, and that, among other mechanisms, 5-HT(1A) receptors may play a role in these effects.

Risperidone-induced type 2 diabetes presenting with diabetic ketoacidosis

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Clarissa Ern Hui Fang

2018-05-01

Full Text Available A 28-year-old male presented with 2 days of vomiting and abdominal pain, preceded by 2 weeks of thirst, polyuria and polydipsia. He had recently started risperidone for obsessive-compulsive disorder. He reported a high dietary sugar intake and had a strong family history of type 2 diabetes mellitus (T2DM. On admission, he was tachycardic, tachypnoeic and drowsy with a Glasgow Coma Scale (GCS of 10/15. We noted axillary acanthosis nigricans and obesity (BMI 33.2 kg/m2. Dipstick urinalysis showed ketonuria and glycosuria. Blood results were consistent with diabetic ketoacidosis (DKA, with hyperosmolar state. We initiated our DKA protocol, with intravenous insulin, fluids and potassium, and we discontinued risperidone. His obesity, family history of T2DM, acanthosis nigricans and hyperosmolar state prompted consideration of T2DM presenting with ‘ketosis-prone diabetes’ (KPD rather than T1DM. Antibody markers of beta-cell autoimmunity were subsequently negative. Four weeks later, he had modified his diet and lost weight, and his metabolic parameters had normalised. We reduced his total daily insulin dose from 35 to 18 units and introduced metformin. We stopped insulin completely by week 7. At 6 months, his glucometer readings and glycated haemoglobin (HbA1c level had normalised.

[Atypical antipsychotics and sexual dysfunction: five case-reports associated with risperidone].

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Haefliger, T; Bonsack, C

2006-01-01

Sexual and reproductive function side effects of atypical antipsychotics are frequent, often underestimated and badly tolerated. They contribute to the 50% rate of non-compliance reported for treated patients. Prevalence of sexual dysfunction associated with atypical antipsychotic treatment is high, varying from 18 to 96%. Atypical antipsychotics aren't, as a group, much better than typical antipsychotics, and among them, risperidone seems to induce more and quetiapine less sexual dysfunction. Most atypicals are non-selective, and have actions on multiple central and peripheral receptors. Among these, dopaminergic blockade could have a direct - altering motivation (desire) and reward (orgasm) - and an indirect negative influence on sexuality. Actually, the secondary hyperprolactinemia induced by some antipsychotics (typical antipsychotics, risperidone and amisulpiride), is dose-dependent, more pronounced for female patients, and may have a detrimental effect on sexual function. It also may result in hypogonadism, particularly for female patients. The long-term consequences of this secondary hypogonadism are subject to debate but potentially severe. Furthermore, the blocking and/or modulating actions of atypical antipsychotics on adrenaline, serotonine, histamine or acetyl-choline receptors all have the potential to contribute to secondary sexual problems. The pharmacological profile of risperidone, characterized by a strong affinity for D2 and alpha1 receptors, correlates with his tendency to significantly elevate prolactin levels and to produce ejaculatory disturbances. FIVE CASE-REPORTS: We describe five case-reports of sexual or hormonal disturbances associated with risperidone treatment: two cases of ejaculatory disturbance, one case of galactorrhea and two cases of amenorrhea. Alberto and David are two young male schizophrenic patients, treated with risperidone, and complaining of a total absence of ejaculation despite a preserved orgasm. Many recent case

Triiodothyronine accelerates and enhances the antipsychotic effect of risperidone in acute schizophrenia.

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Steibliene, Vesta; Bunevicius, Adomas; Savickas, Arunas; Prange, Arthur J; Nemeroff, Charles B; Bunevicius, Robertas

2016-02-01

In acute psychotic schizophrenia patients we investigated if the combination of triiodothyronine (T3) plus risperidone was more effective when compared to risperidone monotherapy. Thirty-two in-patients meeting the DSM-IV-TR diagnostic criteria for schizophrenia and without thyroid disease received risperidone (flexibly adjusted dose for tolerability) and were randomized to additionally receive either T3 (25 μg daily; risperidone plus T3 group) or placebo (risperidone plus placebo group). Treatment lasted until meeting the response to treatment criteria defined as score of ≤ 3 on the Clinical Global Impression Severity and Improvement scales. Acute psychotic episode symptom severity was evaluated using the Brief Psychiatric Rating Scale (BPRS) at treatment initiation and at the final study assessment. Fourteen patients were randomized to receive risperidone plus T3 and eighteen to receive risperidone plus placebo. The time until treatment response was shorter in the risperidone plus T3 group relative to the risperidone plus placebo group (25.5 ± 4.4 days vs 32.2 ± 8.2 days, respectively; p = 0.001). Moreover, there was a greater reduction of BPRS-total score (p = 0.01) in the risperidone plus T3 group relative to the risperidone plus placebo group. Treatment with T3 was associated with shorter time to treatment response (β = -0.440, p = 0.022) and with greater improvement in BPRS score (β = 0.240, p = 0.053), independent of patients' gender, age, baseline BPRS score and mean risperidone dose. The study confirms that addition of T3 to risperidone was associated with accelerated and enhanced treatment response in acutely psychotic schizophrenic patients. Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparison of Risperidone and Olanzapine in Bipolar and Schizoaffective Disorders

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Masand, Prakash S.; Wang, Xiaohong; Gupta, Sanjay; Schwartz, Thomas L.; Virk, Subhdeep; Hameed, Ahmad

2002-01-01

Objective: To compare risperidone and olanzapine for efficacy, tolerability, need for concomitant mood stabilizers, and cost of treatment in bipolar and schizoaffective disorders. Method: We conducted a retrospective chart review of 36 consecutive outpatients with DSM-IV bipolar or schizoaffective disorder seen in 3 settings who received risperidone or olanzapine for at least 1 month between May and August 1997. Results: The mean ± SD doses were 3.7 ± 3.5 mg/day of risperidone and 12.0 ± 5.4 mg/day of olanzapine. Between-treatment differences in patient characteristics, psychiatric history, Clinical Global Impressions scale ratings, and duration of treatment were not significant. Similar proportions of patients in the 2 groups reported side effects, including extrapyramidal symptoms, akathisia, tardive dyskinesia, and precipitation of mania by the respective drug. Patients in the olanzapine group received a significantly higher dose of concomitant lithium than those receiving risperidone (mean daily lithium doses: risperidone group, 750 ± 150 mg; olanzapine group, 1211 ± 186 mg; p = .006). The total daily acquisition cost per patient was $11.84 for olanzapine versus $5.81 for risperidone. Conclusion: Olanzapine and risperidone were equally efficacious and safe in the treatment of patients with bipolar or schizoaffective disorder, but treatment costs and dose of concomitant lithium were lower in risperidone-treated patients. PMID:15014747

P-glycoprotein interaction with risperidone and 9-OH-risperidone studied in vitro, in knock-out mice and in drug-drug interaction experiments

DEFF Research Database (Denmark)

Ejsing, Thomas B.; Pedersen, Anne D.; Linnet, Kristian

2005-01-01

P-glycoprotein, risperidone, nortriptyline, cyclosporine A, drug-drug interaction, blood-brain barrier, knock-out mice......P-glycoprotein, risperidone, nortriptyline, cyclosporine A, drug-drug interaction, blood-brain barrier, knock-out mice...

The Determinants of Banking Crises and Currency Crises

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Young Mok Bae

2005-06-01

Full Text Available This paper studies the factors associated with the emergence of banking crises and currency crises and the interrelationship between the two crises in 21 American, European and Asian countries in 1973~2000 using a multivariate logit econometric model. And this analysis attempts to introduce the lag model to solve the causality problems in banking crises and currency crises. In case of the simple binary models without lag, banking crises were associated with economic recession, inflation, depreciation, the rise of real interest rate, lending boom. But in case of lag models, banking crises were caused by economic recession, inflation, the rise of real interest rate, lending boom, the rise of reserve ratio, the liberalization of capital account. Currency crises were associated with economic recession, the larger deficit of current account relative to import in case of the simple binary models without lag, But in case of lag models, currency crises were caused by economic recession, the rapid decrease of net foreign assets of banks, and the larger deficit of current account relative to import. And this analysis shows that currency crises can be a cause of banking crises, not vice versa. Nevertheless the two types of crises have positive correlation with each other.

Treatment of delirium with risperidone in cancer patients.

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Kishi, Yasuhiro; Kato, Masashi; Okuyama, Toru; Thurber, Steven

2012-08-01

Antipsychotic medications have frequently been regarded as the treatment of choice for delirium. This study examined the clinical efficacy of risperidone for the treatment of delirium in cancer patients, combined with a repeated assessment of underlying medical severity levels. The study included consecutive referrals of 29 delirious cancer patients (mean age, 68.9 ± 12.5 years; male, 69%) to the psychiatric consultation service. Risperidone was given orally once per day (mean dosage, 1.4 ± 1.3 mg/day). Study participants were assessed using quantitative standardized scales of cognitive function, delirium, and physical impairment at baseline and at the end of the study (seventh day). Risperidone with routine clinical management was effective for the treatment of delirium: 48% of the patients responded and 38% achieved remission. The reduction of delirium severity occurred in 79% of the patients. Changes in delirium severity were unrelated to age, gender, general cognitive dysfunction, or to severity of attendant medical conditions. In addition to changes in agitation and perceptional disturbances, risperidone was also effective for other specific delirium symptoms. Risperidone with routine clinical management is effective in the treatment of delirium in advanced cancer patients, independent of changes in the underlying medical condition. © 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology.

Risperidone and Risk of Gynecomastia in Young Men.

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Etminan, Mahyar; Carleton, Bruce; Brophy, James M

2015-11-01

The purpose of this study was to quantify the risk of gynecomastia with risperidone in adolescent and young adult males. We created a cohort of males 15-25 years of age from the IMS LifeLink database, and conducted a case-control study within the cohort by identifying all new cases of gynecomastia. For each case, 10 controls were selected and matched to the cases by age, follow-up, and calendar times (cases and controls had the same follow up time and cohort entry date). Rate ratios (RR) for current use of risperidone were computed adjusting for potential confounding variables. First diagnosis of gynecomastia was made based on International Classification of Diseases, 9th revision (ICD-9) for gynecomastia. There were 401,924 males ages 15-25 in the primary cohort. There were 1556 cases of gynecomastia and 15,560 corresponding controls. Current users of risperidone had approximately four times the risk of developing gynecomastia than non-users (RR=3.91, 95% CI=2.01-7.62). When the analysis was stratified to children and adolescents (≤18 years of age) taking risperidone, the risk of gynecomastia was five times higher than for non-users (RR=5.44, 95% CI=1.50-19.74). Risperidone is associated with an increase with the risk of gynecomastia in adolescent and young adult males.

Crises-induced intermittencies in a coherently driven system of two-level atoms

International Nuclear Information System (INIS)

Pando L, C.L.; Perez, G.; Cerdeira, H.A.

1993-04-01

We study the coherent dynamics of a thin layer of two-level atoms driven by an external coherent field and a phase conjugated mirror (PCM). Since the variables of the system are defined on the Bloch sphere, the third dimension is provided by the temporal modulation of the Rabi frequencies, which are induced by a PCM which reflects an electric field with a carrier frequency different from the incident one. We show that as the PCM gain coefficient is changed period doubling leading to chaos occurs. We find crises of attractor merging and attractor widening types related to homoclinic and heteroclinic tangencies respectively. For the attractor merging crises we find the critical exponent for the characteristic time of intermittency versus the control parameter which is given by the gain coefficient of the PCM. We show that during the crises of attractor widening type, another crisis due to attractor destruction occurs as the control parameter is changed. The latter is due to the collision of the old attractor with its basin boundary when a new attractor is created. This new attractor is stable only in a very small interval in the neighborhood of this second crisis. (author). 31 refs, 15 figs

Cost-effectiveness model of long-acting risperidone in schizophrenia in the US.

Science.gov (United States)

Edwards, Natalie C; Rupnow, Marcia F T; Pashos, Chris L; Botteman, Marc F; Diamond, Ronald J

2005-01-01

Schizophrenia is a devastating and costly illness that affects 1% of the population in the US. Effective pharmacological therapies are available but suboptimal patient adherence to either acute or long-term therapeutic regimens reduces their effectiveness. The availability of a long-acting injection (LAI) formulation of risperidone may increase adherence and improve clinical and economic outcomes for people with schizophrenia. To assess the cost effectiveness of risperidone LAI compared with oral risperidone, oral olanzapine and haloperidol decanoate LAI over a 1-year time period in outpatients with schizophrenia who had previously suffered a relapse requiring hospitalisation. US healthcare system. Published medical literature, unpublished data from clinical trials and a consumer health database, and a clinical expert panel were used to populate a decision-analysis model comparing the four treatment alternatives. The model captured: rates of patient compliance; rates, frequency and duration of relapse; incidence of adverse events (bodyweight gain and extrapyramidal effects); and healthcare resource utilisation and associated costs. Primary outcomes were: the proportion of patients with relapse; the frequency of relapse per patient; the number of relapse days per patient; and total direct medical cost per patient per year. Costs are in year 2002 US dollars. Based on model projections, the proportions of patients experiencing a relapse requiring hospitalisation after 1 year of treatment were 66% for haloperidol decanoate LAI, 41% for oral risperidone and oral olanzapine and 26% for risperidone LAI, while the proportion of patients with a relapse not requiring hospitalisation were 60%, 37%, 37% and 24%, respectively. The mean number of days of relapse requiring hospitalisation per patient per year was 28 for haloperidol decanoate LAI, 18 for oral risperidone and oral olanzapine and 11 for risperidone LAI, while the mean number of days of relapse not requiring

Cognitive and psychomotor effects of risperidone in schizophrenia and schizoaffective disorder.

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Houthoofd, Sofie A M K; Morrens, Manuel; Sabbe, Bernard G C

2008-09-01

The aim of this review was to discuss data from double-blind, randomized controlled trials (RCTs) that have investigated the effects of oral and long-acting injectable risperidone on cognitive and psychomotor functioning in patients with schizophrenia or schizoaffective disorder. PubMed/MEDLINE and the Institute of Scientific Information Web of Science database were searched for relevant English-language double-blind RCTs published between March 2000 and July 2008, using the terms schizophrenia, schizoaffective disorder, cognition, risperidone, psychomotor, processing speed, attention, vigilance, working memory, verbal learning, visual learning, reasoning, problem solving, social cognition, MATRICS, and long-acting. Relevant studies included patients with schizophrenia or schizoaffective disorder. Cognitive domains were delineated at the Consensus Conferences of the National Institute of Mental Health-Measurement And Treatment Research to Improve Cognition in Schizophrenia (NIMH-MATRICS). The tests employed to assess each domain and psychomotor functioning, and the within-group and between-group comparisons of risperidone with haloperidol and other atypical antipsychotics, are presented. The results of individual tests were included when they were individually presented and interpretable for either drug; outcomes that were presented as cluster scores or factor structures were excluded. A total of 12 articles were included in this review. Results suggested that the use of oral risperidone appeared to be associated with within-group improvements on the cognitive domains of processing speed, attention/vigilance, verbal and visual learning and memory, and reasoning and problem solving in patients with schizophrenia or schizoaffective disorder. Risperidone and haloperidol seemed to generate similar beneficial effects (on the domains of processing speed, attention/vigilance, [verbal and nonverbal] working memory, and visual learning and memory, as well as psychomotor

Formulation, in vitro and in vivo evaluation of transdermal patches containing risperidone.

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Aggarwal, Geeta; Dhawan, Sanju; Hari Kumar, S L

2013-01-01

The efficacy of oral risperidone treatment in prevention of schizophrenia is well known. However, oral side effects and patient compliance is always a problem for schizophrenics. In this study, risperidone was formulated into matrix transdermal patches to overcome these problems. The formulation factors for such patches, including eudragit RL 100 and eudragit RS 100 as matrix forming polymers, olive oil, groundnut oil and jojoba oil in different concentrations as enhancers and amount of drug loaded were investigated. The transdermal patches containing risperidone were prepared by solvent casting method and characterized for physicochemical and in vitro permeation studies through excised rat skin. Among the tested preparations, formulations with 20% risperidone, 3:2 ERL 100 and ERS 100 as polymers, mixture of olive oil and jojoba oil as enhancer, exhibited greatest cumulative amount of drug permeated (1.87 ± 0.09 mg/cm(2)) in 72 h, so batch ROJ was concluded as optimized formulation and assessed for pharmacokinetic, pharmacodynamic and skin irritation potential. The pharmacokinetic characteristics of the optimized risperidone patch were determined using rabbits, while orally administered risperidone in solution was used for comparison. The calculated relative bioavailability of risperidone transdermal patch was 115.20% with prolonged release of drug. Neuroleptic efficacy of transdermal formulation was assessed by rota-rod and grip test in comparison with control and marketed oral formulations with no skin irritation. This suggests the transdermal application of risperidone holds promise for improved bioavailability and better management of schizophrenia in long-term basis.

Risperidone-associated urinary incontinence in patients with autistic disorder with mental retardation.

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Kumazaki, Hirokazu; Watanabe, Koichiro; Imasaka, Yasushi; Iwata, Kazuhiko; Tomoda, Akemi; Mimura, Masaru

2014-10-01

We report several cases in which patients with autistic disorder with mental retardation who received risperidone experienced urinary incontinence. We retrospectively investigated the medical records of patients housed in facilities for patients with autistic disorder with mental retardation. Those who had undergone a medical examination at a hospital in Tokyo from April 1999 to March 2009 were included in the study.Retrospective data were gathered including age, sex, IQ, birth weight, dosage of risperidone, urinary density, as well as existence of urinary and fecal incontinence. We divided the participants into those who did and did not experience urinary incontinence after taking risperidone and compared the 2 groups. Risperidone had been prescribed to 35 patients. In spite of the fact that no patient had a history of urinary incontinence, 14 patients experienced urinary incontinence after receiving risperidone. Moreover, 4 of these 14 patients also had fecal incontinence. Among the variables we examined, the only significant difference between groups was in sex, with significantly more women experiencing incontinence compared with men. When the dose of risperidone was reduced or the patients switched to other drugs, urinary incontinence of the patients improved.Hence, risperidone may have a casual relationship with urinary incontinence. Further research is needed to understand the pathophysiology of possible effect.

Hyperprolactinemia in Thai children and adolescents with autism spectrum disorder treated with risperidone

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Hongkaew Y

2015-01-01

Full Text Available Yaowaluck Hongkaew,1,2 Nattawat Ngamsamut,3 Apichaya Puangpetch,1,2 Natchaya Vanwong,1,2 Pornpen Srisawasdi,4 Montri Chamnanphon,1,2 Bhunnada Chamkrachchangpada,3 Teerarat Tan-kam,3 Penkhae Limsila,3 Chonlaphat Sukasem1,2 1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine, 2Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC, Ramathibodi Hospital, Mahidol University, 3Yuwaprasart Waithayopathum Child and Adolescent Psychiatric Hospital, Department of Mental Health Services, Ministry of Public Health, 4Division of Clinical Chemistry, Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract: Hyperprolactinemia is a common adverse effect observed in children with autism spectrum disorder (ASD during pharmacotherapy with risperidone. The main aim of this study was to investigate important clinical factors influencing the prolactin response in risperidone-treated Thai ASD. A total of 147 children and adolescents (127 males and 20 females aged 3–19 years with ASD received risperidone treatment (0.10–6.00 mg/day for up to 158 weeks. Prolactin levels were measured by chemiluminescence immunoassay. The clinical data of patients collected from medical records – age, weight, height, body mass index, dose of risperidone, duration of treatment, and drug-use pattern – were recorded. Hyperprolactinemia was observed in 66 of 147 (44.90% subjects. Median prolactin level at the high doses (24.00, interquartile range [IQR] 14.30–29.20 of risperidone was significantly found to be higher than at the recommended (16.20, IQR 10.65–22.30 and low (11.70, IQR 7.51–16.50 doses of risperidone. There was no relationship between prolactin levels and duration of risperidone treatment. Dose-dependence is identified as a main factor associated with hyperprolactinemia in Thai children and adolescents with ASD treated with

Evidence based administration of risperidone and paliperidone for the treating conduct disorder

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Ahmad Ghanizadeh

2013-01-01

Full Text Available Background: This study evaluates the evidence-based administration of risperidone and paliperidone for the treating children and adolescents with conduct disorder (CD. Materials and Methods: A review of the current literature from clinical trials that investigated the efficacy of risperidone and paliperidone on CD considering the inclusion criteria and search strategies was performed by a search of PubMed and Google Scholar databases. Results: Out of 53 titles, 31 were irrelevant. The abstract of 22 potentially related articles were studied. Only six articles reported the results of clinical trial. However, one of them reported the effect of risperidone on conduct behaviors in autistic disorders. One study was a re-analysis of two previous studies, one study reported the effects of maintenance versus withdrawal of risperidone treatment and two studies included children with sub-average intelligence. Headache, somnolence and increased appetite are among the most common reported adverse effects. No study examined the effect of paliperidone on CD was found. Conclusion: Current literature suggests that risperidone could be effective for treating some conduct behaviors in children and adolescents. The effect of risperidone on CD is not a well-researched area. There is no well-controlled evidence based reports about the safety and efficacy of risperidone for the treatment of CD. Further trials should examine the efficacy of these medications on CD rather than conduct behaviors or disruptive behavior disorders.

Effects of co-treatment with mirtazapine and low doses of risperidone on immobility time in the forced swimming test in mice.

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Rogóż, Zofia

2010-01-01

The aim of the present study was to examine the effect of mirtazapine (MIR) and risperidone (an atypical antipsychotic drug), given separately or jointly, on immobility time in the forced swimming test in male C57BL/6J mice. Fluoxetine (FLU) was used as a reference drug. MIR (2.5, 5 and 10 mg/kg) and FLU (5 and 10 mg/kg), or risperidone in low doses (0.05 and 0.1 mg/kg) given alone did not change the immobility time of mice in the forced swimming test. Joint administration of MIR (5 and 10 mg/kg) or FLU (10 mg/kg) and risperidone (0.1 mg/kg) produced antidepressant-like activity in the forced swimming test. WAY100636 (a 5-HT(1A) receptor antagonist) inhibited, while yohimbine (an α(2)-adrenergic receptor antagonist) potentiated the antidepressant-like effect induced by co-administration of MIR and risperidone. Active behavior in that test did not reflect an increase in general activity, since combined administration of antidepressants and risperidone failed to enhance the locomotor activity of mice. The obtained results indicate that risperidone applied in a low dose enhances the antidepressant-like activity of MIR and that, among other mechanisms, 5-HT(1A)-, and α(2)-adrenergic receptors may play a role in this effect.

Peripheral Edema Occurring during Treatment with Risperidone Combined with Citalopram

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Seyed Hamzeh Hosseini

2012-01-01

Full Text Available An 80-year-old female presented with symptoms of depression, worthlessness, hopelessness, loss of energy, insomnia, impatience, and forgetfulness associated with persecutory delusion that had begun about one year before her visit. She was diagnosed with major depression with psychotic signs and began treatment with risperidone (2 mg/night and citalopram (20 mg/day. After 20 days, she returned and reported partial improvement in her symptoms, although she had developed severe swelling of the hands and feet. The results of liver and renal function tests and rheumatologic tests were found to be within normal limits. Risperidone was discontinued for a week, and the swelling resolved completely. Risperidone was then administered again, and the swelling returned so that the patient had to discontinue taking the drug. The reappearance of edema on rechallenge is strong evidence implicating risperidone as the cause of the swelling.

Moderators, mediators, and other predictors of risperidone response in children with autistic disorder and irritability.

Science.gov (United States)

Arnold, L Eugene; Farmer, Cristan; Kraemer, Helena Chmura; Davies, Mark; Witwer, Andrea; Chuang, Shirley; DiSilvestro, Robert; McDougle, Christopher J; McCracken, James; Vitiello, Benedetto; Aman, Michael G; Scahill, Lawrence; Posey, David J; Swiezy, Naomi B

2010-04-01

The National Institute of Mental Health (NIMH) Research Units on Pediatric Psychopharmacology (RUPP) Autism Network found an effect size of d = 1.2 in favor of risperidone on the main outcome measure in an 8-week double-blind, placebo-controlled trial for irritability in autistic disorder. This paper explores moderators and mediators of this effect. Intention-to-treat (ITT) analyses were conducted with suspected moderators and mediators entered into the regression equations. MacArthur Foundation Network subgroup guidelines were followed in the evaluation of the results. Only baseline severity moderated treatment response: Higher severity showed greater improvement for risperidone but not for placebo. Weight gain mediated treatment response negatively: those who gained more weight improved less with risperidone and more with placebo. Compliance correlated with outcome for risperidone but not placebo. Higher dose correlated with worse outcome for placebo, but not risperidone. Of nonspecific predictors, parent education, family income, and low baseline prolactin positively predicted outcome; anxiety, bipolar symptoms, oppositional-defiant symptoms, stereotypy, and hyperactivity negatively predicted outcome. Risperidone moderated the effect of change in 5'-nucleotidase, a marker of zinc status, for which decrease was associated with improvement only with risperidone, not with placebo. The benefit-risk ratio of risperidone is better with greater symptom severity. Risperidone can be individually titrated to optimal dosage for excellent response in the majority of children. Weight gain is not necessary for risperidone benefit and may even detract from it. Socioeconomic advantage, low prolactin, and absence of co-morbid problems nonspecifically predict better outcome. Mineral interactions with risperidone deserve further study.

CYP2D6 polymorphisms and their influence on risperidone treatment

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Puangpetch A

2016-12-01

Full Text Available Apichaya Puangpetch,1 Natchaya Vanwong,1 Nopphadol Nuntamool,2 Yaowaluck Hongkaew,1 Monpat Chamnanphon,1 Chonlaphat Sukasem1 1Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, 2Molecular Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand Abstract: Cytochrome P450 enzyme especially CYP2D6 plays a major role in biotransformation. The interindividual variations of treatment response and toxicity are influenced by the polymorphisms of this enzyme. This review emphasizes the effect of CYP2D6 polymorphisms in risperidone treatment in terms of basic knowledge, pharmacogenetics, effectiveness, adverse events, and clinical practice. Although the previous studies showed different results, the effective responses in risperidone treatment depend on the CYP2D6 polymorphisms. Several studies suggested that CYP2D6 polymorphisms were associated with plasma concentration of risperidone, 9-hydroxyrisperidone, and active moiety but did not impact on clinical outcomes. In addition, CYP2D6 poor metabolizer showed more serious adverse events such as weight gain and prolactin than other predicted phenotype groups. The knowledge of pharmacogenomics of CYP2D6 in risperidone treatment is increasing, and it can be used for the development of personalized medication in term of genetic-based dose recommendation. Moreover, the effects of many factors in risperidone treatment are still being investigated. Both the CYP2D6 genotyping and therapeutic drug monitoring are the important steps to complement the genetic-based risperidone treatment. Keywords: CYP2D6, risperidone, polymorphisms, adverse drug reaction, pharmacogenetics, pharmacokinetics, pharmacodynamics

MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol.

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Deiana, Serena; Watanabe, Akihito; Yamasaki, Yuki; Amada, Naoki; Kikuchi, Tetsuro; Stott, Colin; Riedel, Gernot

2015-12-01

Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801) for induction of social withdrawal in rats and assessed the efficacy of several atypical antipsychotics with different pharmacological profiles as putative treatment. In addition, we reasoned that the marijuana constituent cannabidiol (CBD) may provide benefit or could be proposed as an adjunct treatment in combination with antipsychotics. Hooded Lister rats were tested in the three-chamber version for social interaction, with an initial novelty phase, followed after 3 min by a short-term recognition memory phase. No drug treatment affected sociability. However, distinct effects on social recognition were revealed. MK-801 reduced social recognition memory at all doses (>0.03 mg/kg). Predosing with aripiprazole dose-dependently (2 or 10 mg/kg) prevented the memory decline, but doses of 0.1 mg/kg risperidone or 1 mg/kg olanzapine did not. Intriguingly, CBD impaired social recognition memory (12 and 30 mg/kg) but did not rescue the MK-801-induced deficits. When CBD was combined with protective doses of aripiprazole (CBD-aripiprazole at 12 :  or 5 : 2 mg/kg) the benefit of the antipsychotic was lost. At the same time, activity-related changes in behaviour were excluded as underlying reasons for these pharmacological effects. Collectively, the combined activity of aripiprazole on dopamine D2 and serotonin 5HT1A receptors appears to provide a significant advantage over risperidone and olanzapine with respect to the rescue of cognitive deficits reminiscent of schizophrenia. The differential pharmacological properties of CBD, which are seemingly beneficial in human patients, did not back-translate and rescue the MK-801-induced social memory deficit.

Acute Cervical Dystonia Induced by Clebopride

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Choi, Jin Kyo; Hong, Jin Yong

2017-01-01

Antidopaminergic drugs are known to induce extrapyramidal symptoms. Clebopride, a dopamine antagonist, also can produce parkinsonism, tardive dyskinesia, tardive dystonia, hemifacial dystonia, or oculogyric crisis; however, acute dystonic reaction caused by clebopride has not been reported in adults. We report two young men who experienced acute cervical dystonia within a few days of taking clebopride. The patients recovered after discontinuation of the drug. Physicians prescribing clebopride...

A Comparative Study between Olanzapine and Risperidone in the Management of Schizophrenia

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Saeed Shoja Shafti

2014-01-01

Full Text Available Introduction. Since a variety of comparisons between risperidone and olanzapine have resulted in diverse outcomes, so safety and efficacy of them were compared again in a new trial. Method. Sixty female schizophrenic patients entered into one of the assigned groups for random allocation to olanzapine or risperidone (n=30 in each group in a double-blind, 12-week clinical trial. Scale for Assessment of Positive Symptoms (SAPS and Scale for Assessment of Negative Symptoms (SANS were used as the primary outcome measures. Clinical Global Impressions-Severity Scale (CGI-S, Schedule for Assessment of Insight (SAI, and finally Simpson Angus Scale (SAS as well were employed as secondary scales. Results. While both of olanzapine and risperidone were significantly effective for improvement of positive symptoms (P<0.0001, as regards negative symptoms, it was so only by means of olanzapine (P<0.0003. CGI-S and SAI, as well, were significantly improved in both of the groups. SAS increment was significant only in the risperidone group (P<0.02. Conclusion. While both of olanzapine and risperidone were equally effective for improvement of positive symptoms and insight, olanzapine showed superior efficacy with respect to negative symptoms, along with lesser extrapyramidal side effects, in comparison with risperidone.

Handwriting Movement Analyses for Monitoring Drug-Induced Motor Side Effects in Schizophrenia Patients Treated with Risperidone

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Caligiuri, Michael P.; Teulings, Hans-Leo; Dean, Charles E.; Niculescu, Alexander B.; Lohr, James

2009-01-01

Epidemiologic studies indicate that nearly 60% of schizophrenia (SZ) patients treated with conventional antipsychotic drugs develop extrapyramidal side effects (EPS) such as parkinsonism and tardive dyskinesia. Although the prevalence of EPS has decreased due to the newer antipsychotics, EPS continue to limit the effectiveness of these medicines. Ongoing monitoring of EPS is likely to improve treatment outcome or compliance and reduce the frequency of re-hospitalization. A quantitative analysis of handwriting kinematics was used to evaluate effects of antipsychotic medication type and dose in schizophrenia patients. Twenty-seven schizophrenia patients treated with risperidone, six schizophrenia patients who received no antipsychotic medication and 46 healthy comparison participants were enrolled. Participants performed a 20-minute handwriting task consisting of loops of various sizes and a sentence. Data were captured and analyzed using MovAlyzeR software. Results indicated that risperidone-treated participants exhibited significantly more dysfluent handwriting movements than either healthy or untreated SZ participants. Risperidone-treated participants exhibited lower movement velocities during production of simple loops compared to unmedicated patients. Handwriting dysfluency during sentence writing increased with dose. A 3-factor model consisting of kinematic variables derived from sentence writing accounted for 83% (r = .91) of the variability in medication dose. In contrast, we found no association between observer-based EPS severity ratings and medication dose. These findings support the importance of handwriting-based measures to monitor EPS in medicated schizophrenia patients. PMID:19692133

Risperidone reverses the spatial object recognition impairment and hippocampal BDNF-TrkB signalling system alterations induced by acute MK-801 treatment

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Chen, Guangdong; Lin, Xiaodong; Li, Gongying; Jiang, Diego; Lib, Zhiruo; Jiang, Ronghuan; Zhuo, Chuanjun

2017-01-01

The aim of the present study was to investigate the effects of a commonly-used atypical antipsychotic, risperidone, on alterations in spatial learning and in the hippocampal brain-derived neurotrophic factor (BDNF)-tyrosine receptor kinase B (TrkB) signalling system caused by acute dizocilpine maleate (MK-801) treatment. In experiment 1, adult male Sprague-Dawley rats subjected to acute treatment of either low-dose MK801 (0.1 mg/kg) or normal saline (vehicle) were tested for spatial object recognition and hippocampal expression levels of BDNF, TrkB and the phophorylation of TrkB (p-TrkB). We found that compared to the vehicle, MK-801 treatment impaired spatial object recognition of animals and downregulated the expression levels of p-TrkB. In experiment 2, MK-801- or vehicle-treated animals were further injected with risperidone (0.1 mg/kg) or vehicle before behavioural testing and sacrifice. Of note, we found that risperidone successfully reversed the deleterious effects of MK-801 on spatial object recognition and upregulated the hippocampal BDNF-TrkB signalling system. Collectively, the findings suggest that cognitive deficits from acute N-methyl-D-aspartate receptor blockade may be associated with the hypofunction of hippocampal BDNF-TrkB signalling system and that risperidone was able to reverse these alterations. PMID:28451387

Focus on risperidone.

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Green, B

2000-01-01

Risperidone is a relatively new antipsychotic available world-wide since the early 1990s. It has been characterised as atypical, but shares some of the extrapyramidal side-effect profile of the earlier antipsychotics, when used at doses higher than those recommended by the manufacturer (4-6 mg/day). There is now adequate comparison with conventional antipsychotics to suggest its superiority, but a depot formulation is needed to complete the picture.

Risperidone versus other atypical antipsychotics for schizophrenia

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Komossa, Katja; Rummel-Kluge, Christine; Schwarz, Sandra; Schmid, Franziska; Hunger, Heike; Kissling, Werner; Leucht, Stefan

2014-01-01

Background In many countries of the industrialised world second-generation (“atypical”) antipsychotics (SGAs) have become the first line drug treatment for people with schizophrenia. The question as to whether and if so how much the effects of the various SGAs differ is a matter of debate. In this review we examined how the efficacy and tolerability of risperidone differs from that of other SGAs. Objectives To evaluate the effects of risperidone compared with other atypical antipsychotics for people with schizophrenia and schizophrenia-like psychosis. Search methods 1. Electronic searching We searched the Cochrane Schizophrenia Group Trials Register (April 2007) which is based on regular searches of BIOSIS, CENTRAL, CINAHL, EMBASE, MEDLINE and PsycINFO. 2. Reference searching We inspected the references of all identified studies for more trials. 3. Personal contact We contacted the first author of each included study for missing information. 4. Drug companies We contacted the manufacturers of all atypical antipsychotics included for additional data. Selection criteria We included all randomised, blinded trials comparing oral risperidone with oral forms of amisulpride, aripiprazole, clozapine, olanzapine, quetiapine, sertindole, ziprasidone or zotepine in people with schizophrenia or schizophrenia-like psychosis. Data collection and analysis We extracted data independently. For dichotomous data we calculated risk ratio (RR) and their 95% confidence intervals (CI) on an intention-to-treat basis based on a random-effects model. We calculated numbers needed to treat/harm (NNT/NNH) where appropriate. For continuous data, we calculated mean differences (MD), again based on a random-effects model. Main results The review currently includes 45 blinded RCTs with 7760 participants. The number of RCTs available for each comparison varied: four studies compared risperidone with amisulpride, two with aripiprazole, 11 with clozapine, 23 with olanzapine, eleven with

Cost effectiveness of long-acting risperidone injection versus alternative antipsychotic agents in patients with schizophrenia in the USA.

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Edwards, Natalie C; Locklear, Julie C; Rupnow, Marcia F T; Diamond, Ronald J

2005-01-01

The availability of long-acting risperidone injection may increase adherence and lead to improved clinical and economic outcomes for individuals with schizophrenia. The objective of this study was to assess the cost effectiveness of long-acting risperidone, oral risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, and haloperidol depot in patients with schizophrenia over 1 year from a healthcare system perspective. Published medical literature, unpublished data from clinical trials and a consumer health database, and a clinical expert panel were utilized to populate a decision analytical model comparing the seven treatment alternatives. The model captured rates of patient compliance, the rates, frequency and duration of relapse, incidence of adverse events, and healthcare resource utilization and associated costs. Primary outcomes were expressed in terms of percentage of patients relapsing per year, number of relapse days per year (number and duration of relapses per patient per year), and total direct 2003 medical cost per patient per year. On the basis of model projections, the proportions of patients experiencing a relapse requiring hospitalization in 1 year were 66% for haloperidol depot, 41% for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 26% for long-acting risperidone, whereas the proportions of patients with an exacerbation not requiring hospitalization were 60% for haloperidol depot, 37% for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 24% for long-acting risperidone. The mean number of days of relapse requiring hospitalization per patient per year were 28 for haloperidol depot, 18 for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole, and 11 for long-acting risperidone, whereas the mean number of days of exacerbation not requiring hospitalization were eight for haloperidol depot, five for oral risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole

Pharmacogenetics of Risperidone-Induced Insulin Resistance in Children and Adolescents with Autism Spectrum Disorder.

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Sukasem, Chonlaphat; Vanwong, Natchaya; Srisawasdi, Pornpen; Ngamsamut, Nattawat; Nuntamool, Nopphadol; Hongkaew, Yaowaluck; Puangpetch, Apichaya; Chamkrachangpada, Bhunnada; Limsila, Penkhae

2018-07-01

The purpose of this study was to explore the association of genetic polymorphism of genes related to pharmacokinetics or pharmacodynamics with insulin resistance in children and adolescents with autism spectrum disorder (ASD) and treated with risperidone. All 89 subjects underwent measurement of fasting blood glucose and insulin levels, body-weight and height. Genotyping was performed by TaqMan real-time polymerase chain reaction (PCR) (pharmacokinetics genes: cytochrome P450 2D6 (CYP2D6) *4 (rs3892097), *5 (gene deletion), *10 (rs1065852) and *41 (rs28371725), ATP-binding cassette transporter B1 (ABCB1) 2677 G>T/A (rs2032582) and 3435C>T (rs1045642) and pharmacodynamics genes: dopamine receptor D2 (DRD2) Tag-SNP (C>T) (rs4436578), DRD2 Tag1A (C>T) (rs1800497), leptin gene (LEP) -2548G>A (rs7799039), ghrelin gene (GHRL) -604G>A (rs27647) and brain-derived neurotrophic factor (BDNF) 196G>A (rs6265)). Drug levels were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results revealed that 5 (5.62%) patients presented with hyperglycaemia. Insulin resistance was detected in 15 (16.85%) patients. Insulin resistance was associated with LEP 2548 G>A and BDNF 196 G>A polymorphism (p = 0.051 and p = 0.03). There was no association of pharmacokinetic gene polymorphisms (CYP2D6 and ABCB1) and risperidone levels with insulin resistance. Multiple regression analysis indicated that BDNF 196 G>A polymorphism was significantly associated with insulin resistance (p = 0.025). This finding suggested that BDNF 196 G>A polymorphism may be a genetic marker for predicting insulin resistance before initiating treatment in patients treated with risperidone. Because of the small sample size, further studies are needed to confirm these results. © 2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Early-life risperidone enhances locomotor responses to amphetamine during adulthood.

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Lee Stubbeman, Bobbie; Brown, Clifford J; Yates, Justin R; Bardgett, Mark E

2017-10-05

Antipsychotic drug prescriptions for pediatric populations have increased over the past 20 years, particularly the use of atypical antipsychotic drugs such as risperidone. Most antipsychotic drugs target forebrain dopamine systems, and early-life antipsychotic drug exposure could conceivably reset forebrain neurotransmitter function in a permanent manner that persists into adulthood. This study determined whether chronic risperidone administration during development modified locomotor responses to the dopamine/norepinephrine agonist, D-amphetamine, in adult rats. Thirty-five male Long-Evans rats received an injection of one of four doses of risperidone (vehicle, .3, 1.0, 3.0mg/kg) each day from postnatal day 14 through 42. Locomotor activity was measured for 1h on postnatal days 46 and 47, and then for 24h once a week over the next two weeks. Beginning on postnatal day 75, rats received one of four doses of amphetamine (saline, .3, 1.0, 3.0mg/kg) once a week for four weeks. Locomotor activity was measured for 27h after amphetamine injection. Rats administered risperidone early in life demonstrated increased activity during the 1 and 24h test sessions conducted prior to postnatal day 75. Taking into account baseline group differences, these same rats exhibited significantly more locomotor activity in response to the moderate dose of amphetamine relative to controls. These results suggest that early-life treatment with atypical antipsychotic drugs, like risperidone, permanently alters forebrain catecholamine function and increases sensitivity to drugs that target such function. Copyright © 2017 Elsevier B.V. All rights reserved.

Adjunctive Treatment of Acute Mania with Risperidone versus Typical Antipsychotics: A Retrospective Study

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Jui-Hsiu Tsai

2005-12-01

Full Text Available Few studies have directly compared atypical antipsychotics (e.g. risperidone with typical antipsychotics as adjunctive therapy in patients hospitalized for acute mania, especially during a lengthy hospital stay. Our retrospective, case-controlled study is a chart review of 64 patients with Diagnostic and Statistical Manual of Mental Disorders, 4th edition, defined bipolar I disorder (current episode, mania. Patients were divided into two groups according to the adjunctive medications used: the risperidone group (mood stabilizers plus risperidone and the control group (mood stabilizers plus typical antipsychotics. Outcome at discharge, medications, adverse drug effects, and length of hospital stay were compared between groups, controlling for gender, age, number of prior admissions, and duration of illness. Results indicated no statistically significant differences between groups in the controlled factors, Global Assessment of Functioning and Clinical Global Impression-Improvement scores, and adverse drug events. Patients in the risperidone group used significantly lower doses of trihexyphenidyl than those in the control group (p < 0.05. Patients treated with risperidone had a shorter hospital stay than those treated with typical antipsychotics (p < 0.01. In conclusion, antipsychotics are effective as adjunctive agents in the treatment of acute mania. The use of risperidone, in particular, decreases the need for anticholinergics and may lead to a shorter hospital stay compared with typical antipsychotics.

Acute Cervical Dystonia Induced by Clebopride.

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Choi, Jin Kyo; Hong, Jin Yong

2017-01-01

Antidopaminergic drugs are known to induce extrapyramidal symptoms. Clebopride, a dopamine antagonist, also can produce parkinsonism, tardive dyskinesia, tardive dystonia, hemifacial dystonia, or oculogyric crisis; however, acute dystonic reaction caused by clebopride has not been reported in adults. We report two young men who experienced acute cervical dystonia within a few days of taking clebopride. The patients recovered after discontinuation of the drug. Physicians prescribing clebopride should be aware of the adverse effects of this drug.

Acute Cervical Dystonia Induced by Clebopride

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Jin Kyo Choi

2017-01-01

Full Text Available Antidopaminergic drugs are known to induce extrapyramidal symptoms. Clebopride, a dopamine antagonist, also can produce parkinsonism, tardive dyskinesia, tardive dystonia, hemifacial dystonia, or oculogyric crisis; however, acute dystonic reaction caused by clebopride has not been reported in adults. We report two young men who experienced acute cervical dystonia within a few days of taking clebopride. The patients recovered after discontinuation of the drug. Physicians prescribing clebopride should be aware of the adverse effects of this drug.

Pharmacogenomics and Efficacy of Risperidone Long-Term Treatment in Thai Autistic Children and Adolescents.

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Nuntamool, Nopphadol; Ngamsamut, Nattawat; Vanwong, Natchaya; Puangpetch, Apichaya; Chamnanphon, Monpat; Hongkaew, Yaowaluck; Limsila, Penkhae; Suthisisang, Chuthamanee; Wilffert, Bob; Sukasem, Chonlaphat

2017-10-01

The purpose of this study was to evaluate the association of pharmacogenomic factors and clinical outcome in autistic children and adolescents who were treated with risperidone for long periods. Eighty-two autistic subjects diagnosed with DSM-IV and who were treated with risperidone for more than 1 year were recruited. Pharmacogenomics and clinical outcome (CGI-I, aggressive, overactivity and repetitive score) were evaluated. Almost all patients showed stable symptoms on aggressive behaviour (89.02%), overactivity (71.95%), repetitive (70.89%) behaviour and all clinical symptoms (81.71%). Only 4.48% of patients showed minimally worse CGI-I score. Patients in the non-stable symptom group had DRD2 Taq1A non-wild-type (TT and CT) frequencies higher than the clinically stable group (p = 0.04), whereas other gene polymorphisms showed no significant association. Haplotype ACCTCAT (rs6311, rs1045642, rs1128503, rs1800497, rs4436578, rs1799978, rs6280) showed a significant association with non-stable clinical outcome (χ 2  = 6.642, p = 0.010). Risperidone levels showed no association with any clinical outcome. On the other hand, risperidone dose, 9-OH risperidone levels and prolactin levels were significantly higher in the non-stable compared to the stable symptom group (p = 0.013, p = 0.044, p = 0.030). Increased appetite was the most common adverse drug reaction and associated with higher body-weight, whereas it was not significantly associated with genetic variations and non-genetic information. In conclusion, risperidone showed efficacy to control autism, especially aggressive symptoms in long-term treatment. However, Taq1A T - carrier of dopamine 2 receptor gene - is associated with non-stable response in risperidone-treated patients. This study supports pharmacogenomics testing for personalized therapy with risperidone in autistic children and adolescents. © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

Aripiprazole versus risperidone for treating children and adolescents with tic disorder: a randomized double blind clinical trial.

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Ghanizadeh, Ahmad; Haghighi, Alireza

2014-10-01

There are some uncontrolled studies about the efficacy and safety of both aripiprazole and risperidone for treating tic disorder. Moreover, the efficacy of these medications has never been compared. This is the first double blind randomized clinical trial comparing the safety and efficacy of aripiprazole and risperidone for treating patients with tic disorder. Sixty children and adolescents with tic disorder were randomly allocated into one of the two groups to receive either aripiprazole or risperidone for 2 months. The primary outcome measure was the score of Yale Global Tic Severity Scale. In addition, health related quality of life and adverse events were assessed. Both aripiprazole and risperidone decreased the Yale Global Tic Severity Scale score during this trial. Moreover, both medications increased the health related quality of life score. Both aripiprazole and risperidone were tolerated well. Aripiprazole [3.22 (1.9) mg/day] decreased tic score as much as risperidone [0.6 (0.2) mg/day]. Their adverse effects and their effects on health related quality of life were comparable. However, risperidone increased the patients' social functioning more than aripiprazole in short term.

[Differences in cerebral blood flow following risperidone treatment in children with autistic disorder].

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Ozdemir, Dilşad Foto; Karabacak, Neşe Ilgin; Akkaş, Burcu; Akdemir, Ozgür; Unal, Fatih; Senol, Selahattin

2009-01-01

Functional changes in the brains of autistic children due to risperidone treatment and theirs relationship to the symptom clusters are yet unknown. In this autistic disorder case series we aimed to comparatively evaluate the clinical findings before and after risperidone treatment, and regional cerebral blood flow (rCBF) findings with 99mTc-hexamethylpropyleneamine oxime (HMPAO) brain SPECT. Eleven autistic patients (age range: 6-7 years; 4 girls, 7 boys) received risperidone therapy (1.5-2.5 mg d(-1)) and were followed-up for 3 months. All the patients underwent neurologic examinations, psychometric examinations, and SPECT imaging, both at the start of risperidone treatment and 3 months after the treatment started. Clinical observations, and the observations of parents and teachers were recorded. These results were compared with cerebral perfusion indices obtained from SPECT data. After 3 months of treatment changes in rCBF were observed in various regions and to varying degrees. We observed relationships between clinical symptoms and pre-therapy rCBF findings, and between clinical improvement and rCBF changes. Findings in the present case series are the first to demonstrate a relationship between clinical improvement and regional perfusion patterns after risperidone treatment. We think that these findings may contribute to the understanding of the neurofunctional mechanisms and hypothetical models of autism.

A Randomized Open Label Comparison of the Effects ofRisperidone and Haloperidol on Sexual Function

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S. Jaber Mousavi

2009-12-01

Full Text Available "n Objective: "nSexual dysfunction in patients who take antipsychotics causes adecline in their quality of life and medication acceptance. Considering the restrictions in cross sectional design of many earlier researches, we used a clinical trial aimed at assessing sexual dysfunction by substituting Risperidone, an atypical antipsychotic drug, with Haloperidol, a typical one . "n "n "nMethod: This clinical trial was conducted on 51 patients who had been using Risperidone with a minimum dose of 2 mg/daily for at least 2 months. The patients were randomly divided into 2 groups. The first group continued taking Risperidone, whereas the second group was given Haloperidol. Sexual function prior to and after the drug substitution was assessed using a sexual questionnaire designed to assess four stages of sexual function . "nResults: Compared to those who changed their medication to Haloperidol, the patients who remained on Risperidone therapy suffered from more sexual dysfunction, especially in their tendency towards having sexual activities (P= 0.01, post menstrual sexual activity (P= 0.002, and reaching orgasm in their sexual activities (P= 0.04; however in the Haloperidol group, no significant difference was observed before and after the change in medication . "nConclusion: Although Risperidone and Haloperidol can both disturb patients'sexual function, the side effects of Risperidone are stronger. Hence toprevent the decline of medication acceptance or irregular consumption by patients which may lead to possible relapse, substitution of Risperidone withanother drug with fewer side effects on sexual activities is definitely to the advantage of the patients .

Treatment of anorexia nervosa with long-term risperidone in an outpatient setting: case study.

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Kracke, Elsa J; Tosh, Aneesh K

2014-01-01

There are currently few studies focusing on the efficacy of long-term atypical antipsychotics to treat anorexia nervosa in the pediatric population. This case report follows the treatment of a 17 year-old female with anorexia nervosa over her four-year undergraduate career. After two years of multidisciplinary treatment, low-dose risperidone was initiated due to persistence of her disease. She expressed decreased rigidity around meal times, her weight improved and she had resumption of menses. She was compliant with treatment through graduation and maintained her weight gain. Atypical antipsychotics are a treatment option in the management of anorexia nervosa. Risperidone has not been studied as frequently as olanzapine for eating disorders. Risperidone was chosen for its more favorable side effect profile and decreased cost to the patient. Previous studies on anorexia nervosa treatment have occurred during inpatient treatment and have limited follow-up due to patients' refusal to initiate or maintain medication compliance. This case presents 17 months of outpatient data. The efficacy of risperidone therapy was evaluated with frequent weight checks, subjective decrease in rigidity, serial complete metabolic panels, and restoration of menses. In this case report, an adolescent female treated with low-dose risperidone had decreased rigid thinking, weight gain and resolution of secondary amenorrhea without medication side effects. Therefore, the atypical antipsychotic risperidone may be an effective long-term outpatient treatment option for patients with anorexia nervosa.

Review of risperidone for the treatment of pediatric and adolescent bipolar disorder and schizophrenia

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Jeffrey R Bishop

2008-03-01

Full Text Available Jeffrey R Bishop1,2, Mani N Pavuluri21Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA; 2Department of Psychiatry, Pediatric Mood Disorders Program and Center for Cognitive Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL, USAAbstract: Risperidone is a commonly used medication for the treatment of bipolar disorder and schizophrenia in children and adolescents. It has been studied as a monotherapy treatment in early onset schizophrenia and as both monotherapy and combination therapy for pediatric bipolar disorder. Studies to date indicate that risperidone is an effective treatment for positive and negative symptoms of schizophrenia and mania symptoms of bipolar disorder. In young patient populations, side effects such as weight gain, extrapyramidal side effects, and prolactin elevation require consideration when evaluating the risk benefit ratio for individual patients. Here we review published studies of risperidone for the treatment of bipolar disorder and schizophrenia in children and adolescents to provide practitioners with an overview of published data on the efficacy and safety of risperidone in these patient populations.Keywords: risperidone, bipolar disorder, schizophrenia, children, adolescents

Risperidone – Solid-state characterization and pharmaceutical compatibility using thermal and non-thermal techniques

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Daniel, Josiane Souza Pereira; Veronez, Isabela Pianna; Rodrigues, Larissa Lopes [Laboratório de Análise e Caracterização de Fármacos – LACFar, Instituto de Química, Universidade Federal de Alfenas, Alfenas, Minas Gerais (Brazil); Trevisan, Marcello G. [Laboratório de Análise e Caracterização de Fármacos – LACFar, Instituto de Química, Universidade Federal de Alfenas, Alfenas, Minas Gerais (Brazil); National Institute of Bioanalytics Science and Technology – INCTBio, Institute of Chemistry – UNICAMP, 13084-653, Campinas, São Paulo (Brazil); Garcia, Jerusa Simone, E-mail: jerusa.garcia@unifal-mg.edu.br [Laboratório de Análise e Caracterização de Fármacos – LACFar, Instituto de Química, Universidade Federal de Alfenas, Alfenas, Minas Gerais (Brazil)

2013-09-20

Highlights: • DSC was used to characterize Risperidone and study its compatibility with excipients. • FT-IR associated with PCA was used to complement DSC data. • LC analyzes confirmed the DSC and FT-IR/PCA results. • Risperidone was incompatible with three among five excipients evaluated. - Abstract: A full solid-state characterization of risperidone was conducted using differential scanning calorimetry (DSC), thermogravimetry (TG), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) to examine its physicochemical properties and polymorphism. The primary aim of this work was to study the compatibility of risperidone with pharmaceutical excipients using DSC to obtain and compare the curves of the active pharmaceutical ingredient (API) and the excipients with their 1:1 (w/w) binary mixtures. These same binary mixtures were turned to room temperature and analyzed by FT-IR combined with principal component analysis (PCA) to evaluate solid-state incompatibilities. The chemical incompatibilities of these samples were verified using a stability-indicating liquid chromatography (LC) method to assay for the API and evaluate the formation of degradation products. All of these methods showed incompatibilities between risperidone and the excipients magnesium stearate, lactose and cellulose microcrystalline.

Risperidone in the treatment of behavioral disorders associated with autism in children and adolescents

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Roberto Canitano

2008-09-01

Full Text Available Roberto Canitano, Valeria ScandurraDivision of Child Neuropsychiatry, University Hospital of Siena, Siena, ItalyAbstract: This is a review of the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autistic spectrum disorders (ASD. The main clinical characteristics are impairment in social skills, communication difficulties, repetitive movements and behaviors, including stereotypies. Pharmacotherapy is mainly directed at the so-called target symptoms, ie, behavioral disorders and the various kinds of repetitions associated with ASD. According to the available data, risperidone seems to be moderately efficacious and safe for treating behavioral disorders. 4 double blind controlled trial. 3 reanalysis studies, and 12 open studies have documented the role of risperidone in children with ASD. Controlled studies have been thoroughly considered in this review.Keywords: autism, pervasive developmental disorders, risperidone

Combination treatment with risperidone long-acting injection and psychoeducational approaches for preventing relapse in schizophrenia

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Zhao Y

2013-10-01

Full Text Available Yueren Zhao,1–3 Taro Kishi,1 Nakao Iwata,1 Manabu Ikeda3,4 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Department of Psychiatry, Okehazama Hospital Fujita Kokoro Care Center, Toyoake, Aichi, Japan; 3Department of Neuropsychiatry, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan; 4Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan Abstract: A recent meta-analysis showed that long-acting injectable (LAI antipsychotics were not superior to oral antipsychotics for preventing relapse in patients with schizophrenia. We therefore designed a treatment strategy combining risperidone LAI and COMPASS (COMprehensive Psycho-educational Approach and Scheme Set, an original psychoeducational program supporting treatment with risperidone LAI and evaluating subjective treatment satisfaction, transition of symptoms, and effectiveness in preventing symptomatic relapse. The aim of this study was to examine whether addition of COMPASS to risperidone LAI was more effective in preventing relapse in schizophrenia patients than risperidone LAI alone, with the latter group consisting of patients enrolled in a Phase III trial of risperidone LAI in Japan. Patients were followed up for 6 months, with COMPASS continuously implemented from the transition to the observation phase. The primary efficacy measurements were relapse rate (rates of rehospitalization and discontinuation due to inefficacy. Secondary efficacy measurements were the Brief Psychiatric Rating Scale (BPRS and Global Assessment of Functioning (GAF scores. Of the 96 patients originally enrolled, 19 (19.8% were discontinued from all causes. During the 6-month study period, ten of the 96 patients (10.4% relapsed, compared with a 12.2% relapse rate in patients enrolled in a Phase III trial of risperidone LAI in Japan. Patients showed significant improvements in BPRS total

Managing Crises.

Science.gov (United States)

Eggen, Jerald D.; Mackenzie, R. Alec

1987-01-01

To avoid emergency-driven work environments, crises should be anticipated to the extent possible; steps should be taken to prevent them or limit their consequences. Crises have both internal (personal) and external causes based on poor performance, unreasonable demands, or shifting priorities. Administrators need to cushion deadlines, clarify…

Banking crises : A review

NARCIS (Netherlands)

Laeven, L.

2011-01-01

This review surveys the theoretical and empirical literature on the causes and consequences of banking crises, and summarizes the lessons learned from policy interventions to resolve banking crises. Despite their different origins, banking crises display similar patterns. Their causes lie in

A Cacophony of Crises

DEFF Research Database (Denmark)

Schmidt, Johannes Dragsbæk

2010-01-01

Abstract A cacophony of crises challenges neoliberalism and marks a fundamental reversal in capitalism itself. This is a systemic failure of the capitalist mode of production to renovate and renew itself through a multiplicity of environmental and resource crises and the financial crises which has...

Double-blind, placebo-controlled trial of risperidone plus topiramate in children with autistic disorder.

Science.gov (United States)

Rezaei, Vala; Mohammadi, Mohammad-Reza; Ghanizadeh, Ahmad; Sahraian, Ali; Tabrizi, Mina; Rezazadeh, Shams-Ali; Akhondzadeh, Shahin

2010-10-01

Autism is a complex neurodevelopmental disorder that forms part of a spectrum of related disorders referred to as Autism Spectrum Disorders. The present study assessed the effects of topiramate plus risperidone in the treatment of autistic disorder. Forty children between the ages of 4 and 12 years with a DSM IV clinical diagnosis of autism who were outpatients from a specialty clinic for children were recruited. The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder. Patients were randomly allocated to topiramate+risperidone (Group A) or placebo+risperidone (Group B) for an 8-week, double-blind, placebo-controlled study. The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg. The dose of topiramate was titrated up to 200 mg/day depending on weight (100 mg/day for 30 kg). Patients were assessed at baseline and after 2, 4, 6 and 8 weeks after starting medication. Measure of outcome was the Aberrant Behavior Checklist-Community (ABC-C) Rating Scale. Difference between the two protocols was significant as the group that received topiramate had a greater reduction in ABC-C subscale scores for irritability, stereotypic behavior and hyperactivity/noncompliance. The results suggest that the combination of topiramate with risperidone may be superior to risperidone monotherapy for children with autistic disorder. However the results need to be further confirmed by a larger randomized controlled trial. Copyright © 2010 Elsevier Inc. All rights reserved.

Accounting for Crises

OpenAIRE

Venky Nagar; Gwen Yu

2014-01-01

We provide among the first empirical evidence consistent with recent macro global-game crisis models, which show that the precision of public signals can coordinate crises (e.g., Angeletos and Werning, 2006; Morris and Shin, 2002, 2003). In these models, self-fulfilling crises (independent of poor fundamentals) can occur only when publicly disclosed signals of fundamentals have high precision; poor fundamentals are the sole driver of crises only in low precision settings. We find evidence con...

Risperidone treatment for ADHD in children and adolescents with bipolar disorder

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Joseph Biederman

2008-03-01

Full Text Available Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD. The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder.Methods: This was an open-label, study of risperidone monotherapy for the treatment of pediatric bipolar disorder. Thirty-one children and adolescents 4–15 years of age (7.2 ± 2.8 years of both sexes (71%, N = 22 male with pediatric bipolar disorder (YMRS score = 32.9 ± 8.8 and ADHD (ADHD-RS score = 37.9 ± 8.9 were included in these analyses.Results: Improvement in ADHD symptoms was contingent on improvement in manic symptoms. Although both hyperactive/impulsive (−7.5 ± 5.5.6, p < 0.05 and inattentive (−6.8 ± 5.0, p < 0.05 ADHD symptoms were significantly improved with risperidone, improvement was modest, and only 29% of subjects (N = 6 showed a 30% reduction in ADHD rating scale scores and had a CGI-I ≤ 2.Conclusions: These results suggest that that treatment with risperidone is associated with tangible but generally modest improvement of symptoms of ADHD in children with bipolar disorder.Keywords: ADHD, bipolar disorder, children, risperidone

Pharmacogenomics and Efficacy of Risperidone Long-Term Treatment in Thai Autistic Children and Adolescents

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Nuntamool, Nopphadol; Ngamsamut, Nattawat; Vanwong, Natchaya; Puangpetch, Apichaya; Chamnanphon, Monpat; Hongkaew, Yaowaluck; Limsila, Penkhae; Suthisisang, Chuthamanee; Wilffert, Bob; Sukasem, Chonlaphat

2017-01-01

The purpose of this study was to evaluate the association of pharmacogenomic factors and clinical outcome in autistic children and adolescents who were treated with risperidone for long periods. Eighty-two autistic subjects diagnosed with DSM-IV and who were treated with risperidone for more than

Comparing Efficacy and Side Effects of Memantine vs. Risperidone in the Treatment of Autistic Disorder.

Science.gov (United States)

Nikvarz, Nikvarz; Alaghband-Rad, Javad; Tehrani-Doost, Mehdi; Alimadadi, Abbas; Ghaeli, Padideh

2017-01-01

Introduction: This study was aimed to compare the efficacy and side effects of memantine, an antagonist of the NMDA receptor of glutamate, with risperidone given the fact that glutamate has been noted for its possible effects in the pathogenesis of autism. Risperidone, an atypical antipsychotic, has been approved by FDA for the management of irritability associated with autism. Methods: 30 children, aged 4-17 years, entered an 8-week, randomized trial. Patients were randomly assigned to receive either risperidone or memantine. Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), Clinical Global Impressions - Improvement (CGI-I) and Clinical Global Impression-Severity (CGI-S) scales were used to assess behavioral symptoms of the patients. Results: Both risperidone and memantine reduced the scores of 4 subscales of ABC as well as the 10-item and the total score of CARS significantly. However, differences between the 2 drugs in the scores of each evaluating scale were not found to be significant. Relatively, larger number of patients on risperidone showed "very much improvement" when assessed by CGI-I scale when compared with those on memantine. Discussion and conclusion: The present study suggests that memantine may have beneficial effects in the treatment of many core symptoms of autism. Therefore, memantine may be considered as a potential medication in the treatment of those autistic children who do not respond or cannot tolerate side effects of risperidone. © Georg Thieme Verlag KG Stuttgart · New York.

Different MK-801 administration schedules induce mild to severe learning impairments in an operant conditioning task: role of buspirone and risperidone in ameliorating these cognitive deficits.

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Rapanelli, Maximiliano; Frick, Luciana Romina; Bernardez-Vidal, Micaela; Zanutto, Bonifacio Silvano

2013-11-15

Blockade of N-methyl-d-aspartate receptor (NMDA) by the noncompetitive NMDA receptor (NMDAR) antagonist MK-801 produces behavioral abnormalities and alterations in prefrontal cortex (PFC) functioning. Due to the critical role of the PFC in operant conditioning task learning, we evaluated the effects of acute, repeated postnatal injections of MK-801 (0.1mg/kg) on learning performance. We injected Long-Evans rats i.p. with MK-801 (0.1mg/kg) using three different administration schedules: injection 40 min before beginning the task (during) (n=12); injection twice daily for six consecutive days prior to beginning the experimental procedures (prior) (n=12); or twice daily subcutaneous injections from postnatal day 7 to 11 (postnatal) (n=12). Next, we orally administered risperidone (serotonin receptor 2A and dopamine receptor 2 antagonist, 1mg/kg) or buspirone (serotonin receptor 1A partial agonist, 10mg/kg) to animals treated with the MK-801 schedule described above. The postnatal and prior administration schedules produced severe learning deficits, whereas injection of MK-801 just before training sessions had only mild effects on acquisition of an operant conditioning. Risperidone was able to reverse the detrimental effect of MK-801 in the animals that were treated with MK-801 during and prior training sessions. In contrast, buspirone was only effective at mitigating the cognitive deficits induced by MK-801 when administered during the training procedures. The data demonstrates that NMDA antagonism disrupts basic mechanisms of learning in a simple PFC-mediated operant conditioning task, and that buspirone and risperidone failed to attenuate the learning deficits when NMDA neurotransmission was blocked in the early stages of the postnatal period. Copyright © 2013 Elsevier B.V. All rights reserved.

Can authorities appreciably enhance the prescribing of oral generic risperidone to conserve resources? Findings from across Europe and their implications.

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Godman, Brian; Petzold, Max; Bennett, Kathleen; Bennie, Marion; Bucsics, Anna; Finlayson, Alexander E; Martin, Andrew; Persson, Marie; Piessnegger, Jutta; Raschi, Emanuel; Simoens, Steven; Zara, Corinne; Barbui, Corrado

2014-06-13

Generic atypical antipsychotic drugs offer health authorities opportunities for considerable savings. However, schizophrenia and bipolar disorders are complex diseases that require tailored treatments. Consequently, generally there have been limited demand-side measures by health authorities to encourage the preferential prescribing of generics. This is unlike the situation with hypertension, hypercholaesterolaemia or acid-related stomach disorders.The objectives of this study were to compare the effect of the limited demand-side measures in Western European countries and regions on the subsequent prescribing of risperidone following generics; to utilise the findings to provide future guidance to health authorities; and where possible, to investigate the utilisation of generic versus originator risperidone and the prices for generic risperidone. Principally, this was a segmented regression analysis of retrospective time-series data of the effect of the various initiatives in Belgium, Ireland, Scotland and Sweden following the introduction of generic risperidone. The study included patients prescribed at least one atypical antipsychotic drug up to 20 months before and up to 20 months after generic risperidone. In addition, retrospective observational studies were carried out in Austria and Spain (Catalonia) from 2005 to 2011 as well as one English primary care organisation (Bury Primary Care Trust (PCT)). There was a consistent steady reduction in risperidone as a percentage of total selected atypical antipsychotic utilisation following generics. A similar pattern was seen in Austria and Spain, with stable utilisation in one English PCT. However, there was considerable variation in the utilisation of generic risperidone, ranging from 98% of total risperidone in Scotland to only 14% in Ireland. Similarly, the price of generic risperidone varied considerably. In Scotland, generic risperidone was only 16% of pre-patent loss prices versus 72% in Ireland. Consistent

Quality of life and adverse effects of olanzapine versus risperidone therapy in patients with schizophrenia.

Science.gov (United States)

Chaves, Katarina Melo; Serrano-Blanco, Antoni; Ribeiro, Susana Barbosa; Soares, Luiz Alberto Lira; Guerra, Gerlane Coelho Bernardo; do Socorro Costa Feitosa Alves, Maria; de Araújo Júnior, Raimundo Fernandes; de Paula Soares Rachetti, Vanessa; Filgueira Júnior, Antônio; de Araújo, Aurigena Antunes

2013-03-01

This cross-sectional study aimed to compare the effects of treatment with an atypical antipsychotic drug (olanzapine or risperidone) on quality of life (QoL) and to document adverse effects in 115 patients diagnosed with schizophrenia who attended the ambulatory service of Hospital Dr. João Machado, Natal, Rio Grande do Norte, Brazil. Socioeconomic, sociodemographic, and clinical variables were compared. The QoL Scale validated for Brazil (QLS-BR) was used to evaluate QoL, and adverse effects were assessed using the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale. Data were analyzed using the χ(2) test and Student's t test, with a significance level of 5 %. Patients in both drug groups showed severe impairment in the occupational domain of the QLS-BR. Global QLS-BR scores indicated impairment among risperidone users and severe impairment among olanzapine users. The most significant side effects were associated with risperidone, including asthenia/lassitude/fatigue, somnolence/sedation, paresthesia, change in visual accommodation, increased salivation, diarrhea, orthostatic posture, palpitations/tachycardia, erythema, photosensitivity, weight loss, galactorrhea, decreased sexual desire, erectile/orgasmic dysfunction, vaginal dryness, headache, and physical dependence. QoL was impaired in patients using olanzapine and in those using risperidone. Risperidone use was associated with psychic, neurological, and autonomous adverse effects and other side effects.

Case Report: Valproic Acid and Risperidone Treatment Leading to Development of Hyperammonemia and Mania

Science.gov (United States)

Carlson, Teri; Reynolds, Charles A.; Caplan, Rochelle

2007-01-01

This case report describes two children who developed hyperammonemia together with frank manic behavior during treatment with a combination of valproic acid and risperidone. One child had been maintained on valproic acid for years and risperidone was added. In the second case, valproic acid was introduced to a child who had been treated with…

Risperidone in the treatment of behavioral disorders associated with autism in children and adolescents.

Science.gov (United States)

Canitano, Roberto; Scandurra, Valeria

2008-08-01

This is a review of the clinical trials investigating the efficacy and safety of risperidone in the treatment of children with autistic spectrum disorders (ASD). The main clinical characteristics are impairment in social skills, communication difficulties, repetitive movements and behaviors, including stereotypies. Pharmacotherapy is mainly directed at the so-called target symptoms, ie, behavioral disorders and the various kinds of repetitions associated with ASD. According to the available data, risperidone seems to be moderately efficacious and safe for treating behavioral disorders. 4 double blind controlled trial. 3 reanalysis studies, and 12 open studies have documented the role of risperidone in children with ASD. Controlled studies have been thoroughly considered in this review.

Crise ecologica, crise capitalista, crise de civilização: a alternativa ecossocialista

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Michael Löwy

Full Text Available Neste artigo defende-se a tese que a crise do capitalismo e a crise ecológica resultam da dinâmica do sistema capitalista que transforma seres humanos e recursos naturais em mercadorias necessárias à expansão dos negócios e a acumulação de lucros. Na sua feição atual a crise reflete as dificuldades da civilização capitalista industrial e do seu modo de vida caracterizado pelo american way of life, em manter-se sem rupturas. A questão ecológica, do meio ambiente, é central no capitalismo. As tentativas de soluções, a exemplo da Tratado de Kioto e as medidas pactuadas em Copenhagen em 2008, estão muito aquém das providências necessárias à resolução do problema . O ecosocialismo, em sua utopia, mas sem ser uma abstração, apresenta-se como um paradigma de civilização alternativo.

Risperidone-Induced Renal Damage and Metabolic Side Effects: The Protective Effect of Resveratrol

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Sedat Bilgiç

2017-01-01

Full Text Available Objective. The aim of the study was to investigate the possible protective qualities of resveratrol (RSV against the side effects of risperidone (RIS in an experimental model in rat kidneys with histologic and biochemical assessments. Materials and Methods. Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into five groups: control, untreated rats (n=7 were in group 1; group 2 was given 2 mg/kg/day RIS (n=7; group 3 was treated with 2 mg/kg/day RIS and 20 mg/kg/day RSV (n=7; group 4 was treated with 2 mg/kg/day RIS and 40 mg/kg/day RSV (n=7; and group 5 was treated with 2 mg/kg/day RIS and 80 mg/kg/day RSV (n=7. All treatments were administered for two weeks by gavage. On treatment day 15, kidney tissues were removed for analysis. Results. The results showed that RSV treatment reduced weight gain induced by RIS. In addition, RSV increased the total antioxidant status (TAS and decreased serum creatinine (Cr, blood urea nitrogen (BUN, oxidative stress index (OSI, and total oxidant status (TOS levels significantly (p<0.05. Conclusion. This study revealed that treatment with RSV might protect kidney tissues against the side effects of RIS. RSV could be an effective course of therapy to enhance therapeutic efficacy.

Development of Risperidone PLGA Microspheres

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Susan D’Souza

2014-01-01

Full Text Available The aim of this study was to design and evaluate biodegradable PLGA microspheres for sustained delivery of Risperidone, with an eventual goal of avoiding combination therapy for the treatment of schizophrenia. Two PLGA copolymers (50 : 50 and 75 : 25 were used to prepare four microsphere formulations of Risperidone. The microspheres were characterized by several in vitro techniques. In vivo studies in male Sprague-Dawley rats at 20 and 40 mg/kg doses revealed that all formulations exhibited an initial burst followed by sustained release of the active moiety. Additionally, formulations prepared with 50 : 50 PLGA had a shorter duration of action and lower cumulative AUC levels than the 75 : 25 PLGA microspheres. A simulation of multiple dosing at weekly or 15-day regimen revealed pulsatile behavior for all formulations with steady state being achieved by the second dose. Overall, the clinical use of Formulations A, B, C, or D will eliminate the need for combination oral therapy and reduce time to achieve steady state, with a smaller washout period upon cessation of therapy. Results of this study prove the suitability of using PLGA copolymers of varying composition and molecular weight to develop sustained release formulations that can tailor in vivo behavior and enhance pharmacological effectiveness of the drug.

Symptom response and side-effects of olanzapine and risperidone in young adults with recent onset schizophrenia

NARCIS (Netherlands)

van Bruggen, Johanna; Tijssen, Jans; Dingemans, Petrus; Gersons, Berthold; Linszen, Donald

2003-01-01

The symptom response and side-effects of olanzapine and risperidone were compared in patients with recent onset schizophrenia. Actively symptomatic patients n=44) randomly, received olanzapine 15 mg (median dose) or risperidone 4 mg (median dose). Symptom response and side-effects were measured

Double-blind comparison of ziprasidone and risperidone in the treatment of Chinese patients with acute exacerbation of schizophrenia

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Hongyan Zhang

2011-03-01

Full Text Available Hongyan Zhang1, Huafang Li2, Liang Shu1, Niufan Gu2, Gang Wang3, Yongzhen Weng3, Shiping Xie4, Xinbao Zhang4, Ting Li5, Cui Ma5, Wei Yu6, Bruce Parsons7, Manjula Schou81Institute of Mental Health, Peking University, Beijing, China; 2Shanghai Mental Health Center, Shanghai, China; 3Capital Medical University, Beijing An Ding Hospital, Beijing, China; 4Nanjing Brain Hospital, Nanjing, China; 5Guangzhou Brain Hospital, Guangzhou, China; 6Pfizer China, Beijing, China; 7Pfizer Inc, New York, NY, USA; 8Pfizer Australia, Sydney, AustraliaBackground: The aim of the study was to evaluate the efficacy and safety of ziprasidone versus risperidone in Chinese subjects with acute exacerbation of schizophrenia.Methods: In patients meeting the Chinese Classification of Mental Disorders criteria for schizophrenia and with a Positive and Negative Syndrome Scale (PANSS total score ≥60 were randomly assigned to six weeks of double-blind treatment with ziprasidone 40–80 mg twice daily or risperidone 1–3 mg bid, flexibly dosed. Noninferiority was demonstrated if the upper limit of the two-sided 95% confidence interval (CI for the difference in PANSS total score improvement from baseline in the evaluable population was smaller than the prespecified noninferiority margin of 10 units.Results: The intent-to-treat population comprised 118 ziprasidone-treated and 121 risperidone-treated subjects. Improvement (reduction from baseline to week 6 in PANSS total score was (-35.6 [95% CI: -38.6, -32.6] for ziprasidone and (-37.1 [95% CI: -39.9, -34.4] for risperidone. Noninferiority was demonstrated in the evaluable population with a difference score of 1.5 [95% CI: -2.5, 5.5]. Mean prolactin levels decreased at week 6 compared with baseline for ziprasidone (-3.5 ng/mL, but significantly increased for risperidone (61.1 ng/mL; P < 0.001. More risperidone-treated subjects (14.9% than ziprasidone-treated subjects (4.2% reported weight gain ≥7%. Akathisia and somnolence in

Are We Entering an Era of Concatenated Global Crises?

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Duan Biggs

2011-06-01

Full Text Available An increase in the frequency and intensity of environmental crises associated with accelerating human-induced global change is of substantial concern to policy makers. The potential impacts, especially on the poor, are exacerbated in an increasingly connected world that enables the emergence of crises that are coupled in time and space. We discuss two factors that can interact to contribute to such an increased concatenation of crises: (1 the increasing strength of global vs. local drivers of change, so that changes become increasingly synchronized; and (2 unprecedented potential for the propagation of crises, and an enhanced risk of management interventions in one region becoming drivers elsewhere, because of increased connectivity. We discuss the oil-food-financial crisis of 2007 to 2008 as an example of a concatenated crisis with origin and ultimate impacts in far removed parts of the globe. The potential for a future of concatenated shocks requires adaptations in science and governance including (a an increased tolerance of uncertainty and surprise, (b strengthening capacity for early detection and response to shocks, and (c flexibility in response to enable adaptation and learning.

Frequency of Extrapyramidal Adverse Reactions in Schizophrenic Outpatients Treated with Risperidone, Olanzapine, Quetiapine or Haloperidol : Results of the EIRE Study.

Science.gov (United States)

Bobes, Julio; Rejas, J; Garcia-Garcia, M; Rico-Villademoros, F; García-Portilla, M P; Madrigal, M; Hernández, G

2002-09-01

and risperidone also showed a lower risk of EPS than haloperidol when adjusting by dose. Our results suggest that the atypical antipsychotics studied are less likely to induce extrapyramidal adverse reactions compared with haloperidol in stabilised patients, although these reactions are still common.

Paroxetine and Low-dose Risperidone Induce Serotonin 5-HT1A and Dopamine D2 Receptor Heteromerization in the Mouse Prefrontal Cortex.

Science.gov (United States)

Kolasa, Magdalena; Solich, Joanna; Faron-Górecka, Agata; Żurawek, Dariusz; Pabian, Paulina; Łukasiewicz, Sylwia; Kuśmider, Maciej; Szafran-Pilch, Kinga; Szlachta, Marta; Dziedzicka-Wasylewska, Marta

2018-05-01

Recently, it has been shown that serotonin 5-HT 1A receptor interacts with dopamine D2 receptor in vitro. However, the existence of 5-HT 1A -D2 heteromers in native tissue remains unexplored. In the present study, we investigated 5-HT 1A -D2 receptor heteromerization in mice treated acutely or chronically with paroxetine (10 mg/kg) or risperidone (0.05 mg/kg). Receptor heteromerization was visualized and quantified in the mouse brain by in situ proximity ligation assay (PLA). Additionally, we aimed to determine the cellular localization of 5-HT 1A -D2 receptor heteromers in mouse adult primary neuronal cells by immunofluorescent staining with markers for astrocytes (GFAP) and neurons (NeuN and MAP2). The results from the current study demonstrated that 5-HT 1A and D2 receptor co-localization and heteromerization occurred in the mouse prefrontal cortex. Counterstaining after PLA confirmed neuronal (pyramidal and GABAergic) as well as astrocytal localization of 5-HT 1A -D2 receptor heteromers. Chronic administration of paroxetine or risperidone increased the level of 5-HT 1A -D2 receptor heteromers in the prefrontal cortex. These changes were not accompanied by any changes in the expression of mRNAs (measured by in situ hybridization) or densities of 5-HT 1A and D2 receptors (quantified by receptor autoradiography with [3H]8-OH-DPAT and [3H]domperidone, respectively), what all indicated that paroxetine and risperidone facilitated 5-HT 1A -D2 heteromer formation independently of the receptor expression. In vitro homogenous time-resolved FRET (HTRF) study confirmed the ability of tested drugs to influence the human 5-HT 1A -D2 heteromer formation. The obtained data indicate that the increase in 5-HT 1A -D2 receptor heteromerization is a common molecular characteristic of paroxetine and low-dose risperidone treatment. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Youth unemployment rate and impact of financial crises

NARCIS (Netherlands)

Choudhry, Misbah Tanveer; Marelli, Enrico; Signorelli, Marcello

2012-01-01

Purpose - The purpose of this paper is to assess the impact of financial crises on the youth unemployment rate (YUR). The authors consider different types of financial crises (systemic banking crises, non-systemic banking crises, currency crises and debt crises) and different groups of countries,

Impact of risperidone on leptin and insulin in children and adolescents with autistic spectrum disorders.

Science.gov (United States)

Srisawasdi, Pornpen; Vanwong, Natchaya; Hongkaew, Yaowaluck; Puangpetch, Apichaya; Vanavanan, Somlak; Intachak, Boontarika; Ngamsamut, Nattawat; Limsila, Penkhae; Sukasem, Chonlaphat; Kroll, Martin H

2017-08-01

To evaluate the influence of dose and duration of risperidone treatment on cardiovascular and diabetes risk biomarkers in children and adolescents with autistic spectrum disorders (ASDs). In this cross-sectional analysis, a total of 168 ASDs patients (89% male) treated with a risperidone-based regimen for ≥12months were included. Blood samples were analyzed for glucose and lipid metabolic markers, adiponectin, leptin, prolactin, cortisol and high sensitive C-reactive protein. The mean concentrations of glucose, insulin, prolactin and leptin and HOMA-IR significantly rose with risperidone dosage (all P<0.025), but those of adiponectin and cortisol did not. Using regression analysis, insulin, leptin, prolactin and glucose concentrations and HOMA-IR show significant association with dosage. None of the markers except adiponectin showed dependence on duration of treatment. However, insulin and leptin concentrations and HOMA-IR clearly increased with increasing both dosage and duration. Dosage and duration of treatment had minimal effect on standard lipid profile and lipoprotein subclasses. Risperidone treatment disturbed glucose homeostasis and endocrine regulation (particularly leptin) in children and adolescents with ASDs, in a dose- and duration-dependent manner, being suggestive of leptin and insulin resistance mechanisms. Metabolic adverse effects, especially development of type 2 diabetes mellitus should be closely monitored, particularly in individuals receiving high doses and/or long-term risperidone treatment. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders.

Science.gov (United States)

McDougle, C J; Holmes, J P; Carlson, D C; Pelton, G H; Cohen, D J; Price, L H

1998-07-01

Neurobiological research has implicated the dopamine and serotonin systems in the pathogenesis of autism. Open-label reports suggest that the serotonin2A-dopamine D2 antagonist risperidone may be safe and effective in reducing the interfering symptoms of patients with autism. Thirty-one adults (age [mean+/-SD], 28.1+/-7.3 years) with autistic disorder (n=17) or pervasive developmental disorder not otherwise specified (n=14) participated in a 12-week double-blind, placebo-controlled trial of risperidone. Patients treated with placebo subsequently received a 12-week open-label trial of risperidone. For persons completing the study, 8 (57%) of 14 patients treated with risperidone were categorized as responders (daily dose [mean+/-SD], 2.9+/-1.4 mg) compared with none of 16 in the placebo group (Pautism (Pautism in adults.

A Theoretical Overview of Currency Crises

OpenAIRE

Hongxia, Guo

2005-01-01

In the 1980s and 1990s, currency crises occurred frequently in various parts of the world. This paper provides an overview of the currency crises theories, which investigate the cause of these currency crises, the determinant factors of their depth, and the mechanism of their effects on actual economy. Based on the three-generation classification, this paper surveys currency crises theories with focus on the differences among them.

State network approach to characteristics of financial crises

Science.gov (United States)

Qiu, Lu; Gu, Changgui; Xiao, Qin; Yang, Huijie; Wu, Guolin

2018-02-01

Extensive works have reported that a financial crisis can induce significant changes to topological structure of a stock network constructed with cross-correlations between stocks. But there are still some problems to be answered, such as what is the relationship between different crises in history and how to classify them? In the present work, we propose a new network-based solution to extract and display the relationships between the crises. The Dow Jones stock market is investigated as a typical example. The cross-correlation matrix between stocks is used to measure the state of stock market, called state matrix. All the states cluster into six sub-categories. A state network is constructed further to display the relationships between all the states, which contains a total of nine communities. It is found that three crises C , D and E (refer to the Lehman's bankruptcy in 2008, the Euro-zone and International Monetary Fund decide the first bailout for Greece in 2010, and the European sovereign debt crisis in 2011, respectively) belong to a specific sub-category and cluster in a single community. The mid-stage of C is closely linked with E, while the other stages with D. The other two crises A and B (refer to the financial crisis in Asia in 1997, and the burst of "dot-com bubble" in 2002, respectively) belong to another sub-category and gather in a corner of another single community. A and B are linked directly with C and D by two edges. By this way, we give a clear picture of the relationships between the crises.

Parenteral nanoemulsions as promising carriers for brain delivery of risperidone: Design, characterization and in vivo pharmacokinetic evaluation.

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Đorđević, Sanela M; Cekić, Nebojša D; Savić, Miroslav M; Isailović, Tanja M; Ranđelović, Danijela V; Marković, Bojan D; Savić, Saša R; Timić Stamenić, Tamara; Daniels, Rolf; Savić, Snežana D

2015-09-30

This paper describes design and evaluation of parenteral lecithin-based nanoemulsions intended for brain delivery of risperidone, a poorly water-soluble psychopharmacological drug. The nanoemulsions were prepared through cold/hot high pressure homogenization and characterized regarding droplet size, polydispersity, surface charge, morphology, drug-vehicle interactions, and physical stability. To estimate the simultaneous influence of nanoemulsion formulation and preparation parameters--co-emulsifier type, aqueous phase type, homogenization temperature--on the critical quality attributes of developed nanoemulsions, a general factorial experimental design was applied. From the established design space and stability data, promising risperidone-loaded nanoemulsions (mean size about 160 nm, size distribution Solutol(®) HS15 as co-emulsifier, were produced by hot homogenization and their ability to improve risperidone delivery to the brain was assessed in rats. Pharmacokinetic study demonstrated erratic brain profiles of risperidone following intraperitoneal administration in selected nanoemulsions, most probably due to their different droplet surface properties (different composition of the stabilizing layer). Namely, polysorbate 80-costabilized nanoemulsion showed increased (1.4-7.4-fold higher) risperidone brain availability compared to other nanoemulsions and drug solution, suggesting this nanoemulsion as a promising carrier worth exploring further for brain targeting. Copyright © 2015 Elsevier B.V. All rights reserved.

Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics

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El-Say Khalid M.

2015-12-01

Full Text Available This study was aimed at developing risperidone oral disintegrating mini-tablets (OD-mini-tablets as age-appropriate formulations and to assess their suitability for infants and pediatric use. An experimental Box-Behnken design was applied to assure high quality of the OD-mini-tablets and reduce product variability. The design was employed to understand the influence of the critical excipient combinations on the production of OD-mini-tablets and thus guarantee the feasibility of obtaining products with dosage form uniformity. The variables selected were mannitol percent in Avicel (X1, swelling pressure of the superdisintegrant (X2, and the surface area of Aerosil as a glidant (X3. Risperidone-excipient compatibilities were investigated using FTIR and the spectra did not display any interaction. Fifteen formulations were prepared and evaluated for preand post-compression characteristics. The prepared ODmini- tablet batches were also assessed for disintegration in simulated salivary fluid (SSF, pH 6.2 and in reconstituted skimmed milk. The optimized formula fulfilled the requirements for crushing strength of 5 kN with minimal friability, disintegration times of 8.4 and 53.7 s in SSF and skimmed milk, respectively. This study therefore proposes the risperidone OD-mini-tablet formula having robust mechanical properties, uniform and precise dosing of medication with short disintegration time suitable for pediatric use.

Risperidone oral disintegrating mini-tablets: A robust-product for pediatrics.

Science.gov (United States)

El-Say, Khalid M; Ahmed, Tarek A; Abdelbary, Maged F; Ali, Bahaa E; Aljaeid, Bader M; Zidan, Ahmed S

2015-12-01

This study was aimed at developing risperidone oral disintegrating mini-tablets (OD-mini-tablets) as age-appropriate formulations and to assess their suitability for infants and pediatric use. An experimental Box-Behnken design was applied to assure high quality of the OD-mini-tablets and reduce product variability. The design was employed to understand the influence of the critical excipient combinations on the production of OD-mini-tablets and thus guarantee the feasibility of obtaining products with dosage form uniformity. The variables selected were mannitol percent in Avicel (X1), swelling pressure of the superdisintegrant (X2), and the surface area of Aerosil as a glidant (X3). Risperidone-excipient compatibilities were investigated using FTIR and the spectra did not display any interaction. Fifteen formulations were prepared and evaluated for pre- and post-compression characteristics. The prepared OD-mini-tablet batches were also assessed for disintegration in simulated salivary fluid (SSF, pH 6.2) and in reconstituted skimmed milk. The optimized formula fulfilled the requirements for crushing strength of 5 kN with minimal friability, disintegration times of 8.4 and 53.7 s in SSF and skimmed milk, respectively. This study therefore proposes the risperidone OD-mini-tablet formula having robust mechanical properties, uniform and precise dosing of medication with short disintegration time suitable for pediatric use.

Augmentation by escitalopram, but not citalopram or R-citalopram, of the effects of low-dose risperidone: behavioral, biochemical, and electrophysiological evidence.

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Marcus, Monica M; Jardemark, Kent; Malmerfelt, Anna; Gertow, Jens; Konradsson-Geuken, Asa; Svensson, Torgny H

2012-04-01

Antidepressant drugs are frequently used to treat affective symptoms in schizophrenia. We have recently shown that escitalopram, but not citalopram or R-citalopram, increases firing rate and burst firing of midbrain dopamine neurons, potentiates cortical N-methyl-D-aspartate (NMDA) receptor-mediated transmission and enhances cognition, effects that might influence the outcome of concomitant antipsychotic medication. Here, we studied, in rats, the behavioral and neurobiological effects of adding escitalopram, citalopram, or R-citalopram to the second-generation antipsychotic drug risperidone. We examined antipsychotic efficacy using the conditioned avoidance response (CAR) test, extrapyramidal side effect (EPS) liability using a catalepsy test, dopamine outflow in the medial prefrontal cortex (mPFC) and nucleus accumbens using in vivo microdialysis in freely moving animals, and NMDA receptor-mediated transmission in the mPFC using intracellular electrophysiological recording in vitro. Only escitalopram (5 mg/kg), but not citalopram (10 mg/kg), or R-citalopram (10 mg/kg), dramatically enhanced the antipsychotic-like effect of a low dose of risperidone (0.25 mg/kg), without increasing catalepsy. Given alone, escitalopram, but not citalopram or R-citalopram, markedly enhanced both cortical dopamine output and NMDA receptor-mediated transmission. Addition of escitalopram and to some extent R-citalopram, but not citalopram, significantly enhanced both cortical dopamine output and cortical NMDA receptor-mediated transmission induced by a suboptimal dose/concentration of risperidone. These results suggest that adjunct treatment with escitalopram, but not citalopram, may enhance the effect of a subtherapeutic dose of risperidone on positive, negative, cognitive, and depressive symptoms in schizophrenia, yet without increased EPS liability. Copyright © 2011 Wiley Periodicals, Inc.

Drug Safety Crises Management in Pharmacovigilance

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Gloria Shalviri

2018-05-01

Full Text Available Background: Adverse drug events can cause serious consequences including death. A published report by Lazarou et al in 1998 showed that adverse drug events were the 4th to 6th leading cause of death in the United States. These events may lead to drug safety crises in some issues, which need to take crises management process for solving the problem and/or preventing similar events.Objectives: To evaluate nature of drug safety crises based on adverse events reported to Iranian Pharmacovigilance Center from 1999 through 2012. To mention success and failure outcomes of crises management process taken against detected crises.Methods: All adverse drug events received by Iranian Pharmacovigilance Center from 1999 through 2012 were evaluated for reports with fatal outcome. All alerting letters and manuscripts published by the Center during the same period were reviewed for detailed information on detected crises. World Health Organization definition was used for detecting drug safety crises.Results: Among 42036 registered cases in our database, 463 deaths were recorded. The most frequent suspected drug for adverse events with fatal outcome was ceftriaxone (100 cases. Ten different drug safety crises issues were detected during the study period and their successful or failure outcomes were evaluated. There were 112 issued alerting letters and 17 published manuscript during the same period which was monitored for detailed information.  Conclusion: It is necessary for national pharmacovigilance centers to have prepared programs for crises management. This could be useful for reducing drug related mortality.

Dopamine transporter density assessed with [123]IPT SPECT before and after risperidone treatment in children with tourette's disorder

International Nuclear Information System (INIS)

Ryu, Young Hoon; Kim, Tae Hoon; Ryu, Won Gee

2004-01-01

Tourette's disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the dopamine transporter (DAT) densities between drug-naive children with TD and normal children, and investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using iodine-123 labelled N-(3-iodopropen-2-yl)-2β-carbomethoxy-3beta-(4-chlorophenyl)tropane ([ 123 I]IPT) single photon emission computed tomography (SPECT). [ 123I ]IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in nine drug-naive children with TD. Eleven normal children also underwent SPECT imaging 2 hours after an intravenous administration of [ 123 I]IPT. Drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with risperidone in children with TD was found, although tic symptoms were significantly improved with risperidone. These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system

Effect of risperidone versus haloperidol on emotional responding in schizophrenic patients.

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Fakra, E; Khalfa, S; Da Fonseca, D; Besnier, N; Delaveau, P; Azorin, J M; Blin, O

2008-10-01

Studies on emotional processing report that schizophrenic patients present a specific pattern of emotional responding that usually includes deficits in emotional expressiveness, increased feelings of unpleasant emotion but decreased feelings of pleasant emotion, and increased physiological reactivity. However, studies have rarely controlled the nature of antipsychotic medication. Yet, the influence of these drugs on emotional response is uncertain and could vary depending on their pharmacological profile. This prospective and randomized study aimed to compare the effects of an atypical antipsychotic, risperidone, to a typical one, haloperidol, on patients' emotional responding during an emotional induction task. Twenty-five schizophrenic patients underwent two emotional and clinical evaluations: one before treatment initiation and a second 4 weeks after. Emotional states of fear, sadness, anger, joy, and disgust were induced, as well as a neutral baseline state. Video recordings of patients during the induction task allowed for assessment of emotional expressiveness. Self-reports and measures of skin conductance and heart rate were performed to determine both subjective and physiological reactions to emotional experience. Compared to haloperidol, risperidone did not reduce patients' facial expressiveness, decreased physiological reactivity, and decreased experience of unpleasant emotion but maintained experience of pleasant emotion. Emotional expressiveness was negatively correlated to parkisonism. Our preliminary results suggest that atypical antipsychotics allow for better-adapted patterns of emotional responding than typical ones do. We suggest that this effect is due to reduced striatal D2 blockade, therefore, attenuating akinesia, coupled with increased 5HT and DA levels in prefrontal cortex, which improves emotional regulation.

FINANCIAL CRISES AND TURKEY

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MERT URAL

2013-06-01

Full Text Available Since the last three decades, in developed and developing counties the liberalization and openness efforts have been witnessed. However, financial liberalization attempts (both internal and external without having macroeconomic stability lead to financial crises in many developing countries. Macroeconomic instabilities create fragile financial markets paving the way for future economic crises. The Turkish Economy, completed the liberalization process with foreign trade liberalization in 1980 and by removing controls on capital accounts in 1989. However, since 1990’s economy got into ‘growth-instability-crisis’ vicious circle, because of the fluctuations in the financial structure. By employing a factor analysis (principal components analysis, this work, aims to obtain the factors that effect crises in Turkey.

Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV.

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Mandrioli, Roberto; Mercolini, Laura; Lateana, Domenico; Boncompagni, Giancarlo; Raggi, Maria Augusta

2011-01-15

Risperidone is currently one of the most frequently prescribed atypical antipsychotic drugs; its main active metabolite 9-hydroxyrisperidone contributes significantly to the therapeutic effects observed. An original analytical method is presented for the simultaneous analysis of risperidone and the metabolite in plasma, urine and saliva by high-performance liquid chromatography coupled to an original sample pre-treatment procedure based on micro-extraction by packed sorbent (MEPS). The assays were carried out using a C8 reversed-phase column and a mobile phase composed of 73% (v/v) acidic phosphate buffer (30 mM, pH 3.0) containing 0.23% triethylamine and 27% (v/v) acetonitrile. The UV detector was set at 238 nm and diphenhydramine was used as the internal standard. The sample pre-treatment by MEPS was carried out on a C8 sorbent. The extraction yields values were higher than 92% for risperidone and 90% for 9-hydroxyrisperidone, with RSD for precision always lower than 7.9% for both analytes. Limit of quantification values in the different matrices were 4 ng/mL or lower for risperidone and 6 ng/mL or lower for the metabolite. The method was successfully applied to plasma, urine and saliva samples from psychotic patients undergoing therapy with risperidone, with satisfactory accuracy results (recovery>89%) and no interference from other drugs. Thus, the method seems to be suitable for the therapeutic drug monitoring of schizophrenic patients using the three different biological matrices plasma, urine and saliva. Copyright © 2010 Elsevier B.V. All rights reserved.

An open-label, multicenter evaluation of the long-term safety and efficacy of risperidone in adolescents with schizophrenia

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Pandina Gahan

2012-06-01

Full Text Available Abstract Background Data on the long-term efficacy, safety, and tolerability of risperidone in adolescents with schizophrenia are limited. The objective of this study was to evaluate the efficacy and safety of maintenance risperidone treatment in adolescents with schizophrenia. Methods This open-label study of adolescents aged 13 to 17 years with schizophrenia was a single extension study of two short-term double-blind risperidone studies and also enrolled subjects directly in open-label risperidone treatment. The risperidone dose was flexible and ranged from 2 to 6 mg/day. Most subjects enrolled for 6 months; a subset enrolled for 12 months. Assessment tools included the Positive and Negative Syndrome Scale total and factor scores, Clinical Global Impressions, Children’s Global Assessment Scale, adverse event (AE monitoring, vital signs, laboratory testing, and extrapyramidal symptom rating scales. Results A total of 390 subjects were enrolled; 48 subjects had received placebo in a previous double-blind study; 292 subjects had received risperidone as part of their participation in one of two previous controlled studies; and 50 subjects were enrolled directly for this study. A total of 279 subjects enrolled for 6 months of treatment, and 111 subjects enrolled for 12 months of treatment. Overall, 264 (67.7% subjects completed this study: 209 of the 279 subjects (75% in the 6-month group and 55 of the 111 subjects (50% in the 12-month group. The median mode dose was 3.8 mg/day. At 6 months, all three groups experienced improvement from open-label baseline in symptoms of schizophrenia as well as general assessments of global functioning. Improvements were generally maintained for the duration of treatment. The most common AEs (≥10% of subjects were somnolence, headache, weight increase, hypertonia, insomnia, tremor, and psychosis. Potentially prolactin-related AEs (PPAEs were reported by 36 (9% subjects. The AE profile in this study was

METABOLIC SIDE EFFECTS OF HALOPERIDOL AND RISPERIDONE- A SIX MONTHS FOLLOWUP STUDY

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Kalaimathi B

2017-03-01

Full Text Available BACKGROUND To compare and analyse the metabolic side effects of Risperidone and Haloperidol in newly diagnosed drug-naive schizophrenic disorder patients attending Govt. Stanley Medical College Hospital during initial 6 months of therapy. MATERIALS AND METHODS Newly diagnosed drug-naïve Schizophrenic Patients (n = 60 aged between 18 - 45 years are recruited and randomly allocated into Group A (Risperidone 4 - 6 mg daily and Group B (Haloperidol 5 - 10 mg daily after getting informed consent from the patient’s family members. Patients are followed up monthly for the occurrence of metabolic abnormalities like weight gain, rise in blood pressure, elevated fasting, post-prandial blood sugar level, dyslipidaemia for a period of 6 months. RESULTS Risperidone group showed the mean body weight increase from 64.40 to 69.27, SBP/DBP increase from 123.80/79 to 129.90/83.13; FBS/PPBS increase from 100.20/129.30 to 135.40/185.00; TC increase from 177.23 to 206.23; LDL from 124.30 to 158.30; HDL 48.83 to 50.07; TG 133.47 to 197.83: Haloperidol group showed the mean body weight increase from 64.07 to 68.48, SBP/DBP increase from 123.80/79.00 to 124.27/81.67; FBS/PPBS increase from 100.20/129.30 to 119.87/167.10; TC increase from 177.23 to 197.40; LDL from 119.77 to 139.00; HDL remained 48.83; TG 133.47 to 171.40. CONCLUSION This study showed that patients in both the groups had weight gain, rise in blood sugar, LDL cholesterol and Triglycerides level, but the rise was significant in patients on Risperidone when compared to those on Haloperidol during the 6-month followup.

Comparative study on clinically latent aggressiveness inoutpatients with schizophrenia treated with classical antipsychotics and with risperidone

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Konstantinos Tsirigotis

2014-03-01

Full Text Available Objective: The use of neuroleptics causes not only regression of psychotic symptoms; neuroleptics affect also the patients’ mental state which is changing not only due to medications effects but also secondarily, as a result of regression of psychotic symptoms. The aim of this study was evaluation of subjectively felt “silent” (clinically latent hostility and aggressiveness in patients with paranoid schizophrenia treated with typical neuroleptics and risperidone. Material and methods: Sixty patients (30 patients treated with typical neuroleptics and the other 30 – with risperidone were examined with the Polish version of the following tools: Minnesota Multiphasic Personality Inventory (MMPI, Adjective Check List (ACL and Stern Activities Index (SAI. Results: The statistical analysis of the obtained results yielded many statistically significant differences within the intensity of hostility and aggressiveness in the examined groups. Conclusions: The results of this study showed a higher severity of psychological and personality problems in patients treated with typical neuroleptics, as compared to those treated with risperidone. In patients with paranoid schizophrenia treated with risperidone a lower severity of psychopathological, especially schizophrenic and paranoid, symptoms and lower hostility and aggressiveness were found. Considering that risperidone improves verbal functions, it can be assumed that this entails an improvement in the patients’ communicative competences, thereby improving also their interpersonal relationships. The results of this study indicate a higher susceptibility of people in this group to social influences and less hostility and negativity experienced by them.

Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study.

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Chen, Hongying; Fan, Yong; Zhao, Lei; Hao, Yong; Zhou, Xiajun; Guan, Yangtai; Li, Zezhi

2017-09-01

The relationship between peripheral 5-HT3A receptor mRNA level and risperidone efficiency in paranoid schizophrenia patients is still unknown. A total 52 first-episode and drug-naive paranoid schizophrenia patients who were treated with risperidone and 53 matched healthy controls were enrolled. Patients were naturalistically followed up for 8 weeks. Positive and Negative Syndrome Scale (PANSS) was applied to assess symptom severity of the patients at baseline and at the end of 8th week. There was no difference in 5-HT3A receptor mRNA level between paranoid schizophrenia patients and healthy controls at baseline ( p  = .24). Among 47 patients who completed 8-week naturalistic follow-up, 37 were responders to risperidone treatment. 5-HT3A receptor mRNA level of paranoid schizophrenia patients did not change in overall patients after 8-week treatment with risperidone ( p  = .29). However, 5-HT3A receptor mRNA level in responders increased significantly ( p  = .04), but not in nonresponders ( p  = .81). Successful treatment with risperidone increases 5-HT3A receptor gene expression in patients with paranoid schizophrenia, indicating that 5-HT3A receptor may be involved in the mechanism of risperidone effect.

Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: A comparison of efficacy, safety, and side effects.

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Boettger, Soenke; Jenewein, Josef; Breitbart, William

2015-08-01

The aim of this study was to compare the efficacy and side-effect profile of the typical antipsychotic haloperidol with that of the atypical antipsychotics risperidone, olanzapine, and aripiprazole in the management of delirium. The Memorial Delirium Assessment Scale (MDAS), the Karnofsky Performance Status (KPS) scale, and a side-effect rating were recorded at baseline (T1), after 2-3 days (T2), and after 4-7 days (T3). Some 21 cases were case-matched by age, preexisting dementia, and baseline MDAS scores, and subsequently analyzed. The baseline characteristics of the medication groups were not different: The mean age of the patients ranged from 64.0 to 69.6 years, dementia was present in between 23.8 and 28.6%, and baseline MDAS scores were 19.9 (haloperidol), 18.6 (risperidone), 19.4 (olanzapine), and 18.0 (aripiprazole). The doses of medication at T3 were 5.5 mg haloperidol, 1.3 mg risperidone, 7.1 mg olanzapine, and 18.3 mg aripiprazole. Over one week, the decline in MDAS scores between medications was equal, and no differences between individual MDAS scores existed at T2 or T3. After one week, the MDAS scores were 6.8 (haloperidol), 7.1 (risperidone), 11.7 (olanzapine), and 8.3 (aripiprazole). At T2, delirium resolution occurred in 42.9-52.4% of cases and at T3 in 61.9-85.7%; no differences in assessments between medications existed. Recorded side effects were extrapyramidal symptoms (EPSs) in haloperidol- and risperidone-managed patients (19 and 4.8%, respectively) and sedation with olanzapine (28.6%). Haloperidol, risperidone, aripiprazole, and olanzapine were equally effective in the management of delirium; however, they differed in terms of their side-effect profile. Extrapyramidal symptoms were most frequently recorded with haloperidol, and sedation occurred most frequently with olanzapine.

[Crises of trust].

Science.gov (United States)

Chen, Thai-Form; Tseng, Hsing-Chau

2006-02-01

Extensive media coverage is warning of a crisis of trust that has emerged as a serious issue in our society. This article explores the meaning of "crisis," concepts of crisis management, mechanisms for building trust, and the underlying significance of trust and distrust. Evidence is adduced to testify to the erosion of trust and factors in our society that reflect the potential for crises of trust. Organizational decision makers, including hospital managers, are urged to identify and reflect upon weaknesses in their organizations in order that remedial action can be taken to preempt such crises.

A comparison of low-dose risperidone to paroxetine in the treatment of panic attacks: a randomized, single-blind study

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Galynker Igor I

2009-05-01

Full Text Available Abstract Background Because a large proportion of patients with panic attacks receiving approved pharmacotherapy do not respond or respond poorly to medication, it is important to identify additional therapeutic strategies for the management of panic symptoms. This article describes a randomized, rater-blind study comparing low-dose risperidone to standard-of-care paroxetine for the treatment of panic attacks. Methods Fifty six subjects with a history of panic attacks were randomized to receive either risperidone or paroxetine. The subjects were then followed for eight weeks. Outcome measures included the Panic Disorder Severity Scale (PDSS, the Hamilton Anxiety Scale (Ham-A, the Hamilton Depression Rating Scale (Ham-D, the Sheehan Panic Anxiety Scale-Patient (SPAS-P, and the Clinical Global Impression scale (CGI. Results All subjects demonstrated a reduction in both the frequency and severity of panic attacks regardless of treatment received. Statistically significant improvements in rating scale scores for both groups were identified for the PDSS, the Ham-A, the Ham-D, and the CGI. There was no difference between treatment groups in the improvement in scores on the measures PDSS, Ham-A, Ham-D, and CGI. Post hoc tests suggest that subjects receiving risperidone may have a quicker clinical response than subjects receiving paroxetine. Conclusion We can identify no difference in the efficacy of paroxetine and low-dose risperidone in the treatment of panic attacks. Low-dose risperidone appears to be tolerated equally well as paroxetine. Low-dose risperidone may be an effective treatment for anxiety disorders in which panic attacks are a significant component. Trial Registration ClinicalTrials.gov Identifier: NCT100457106

Coercive Diplomacy: Countering War-Threatening Crises and Armed Conflicts

DEFF Research Database (Denmark)

Jakobsen, Peter Viggo

2015-01-01

Nowadays states rarely resort to war to defeat each other or to address war-threatening crises and armed conflicts. Instead, coercive diplomacy has emerged as their strategy of choice when persuasion and other non-military instruments fall short. Coercive diplomacy involves the use of military...... threats and/or limited force (sticks) coupled with inducements and assurances (carrots) in order to influence the opponent to do something it would prefer not to. States use coercive diplomacy in the hope of achieving their objectives without having to resort to full-scale war. This chapter presents...... the strategy of coercive diplomacy and its requirements for success and shows how states have employed it to manage crises and conflicts during the three strategic eras that the world has passed through since the end of the Cold War....

Humanitarian Crises, Intervention and Security

NARCIS (Netherlands)

Heyse, Liesbet; Zwitter, Andrej; Wittek, Rafael; Herman, Joost

2014-01-01

This book presents a new framework of analysis to assess natural and man-made disasters and humanitarian crises, and the feasibility of interventions in these complex emergencies. The past half-century has witnessed a dramatic increase in such crises – such as in Haiti, Iraq and Sudan – and this

Financial crises and monetary policy

NARCIS (Netherlands)

Goderis, B.V.G.

2005-01-01

In the last three decades, many countries and regions around the world have suffered from currency crises. This thesis investigates the causes of such crises and assesses the role of monetary policy as a tool to avoid them or limit the damage they impose. In addition, it studies the impact of the

Crises in clinical care: an approach to management.

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Runciman, W B; Merry, A F

2005-06-01

A "crisis" in health care is "the point in the course of a disease at which a decisive change occurs, leading either to recovery or to death". The daunting challenges faced by clinicians when confronted with a crisis are illustrated by a tragic case in which a teenage boy died after a minor surgical procedure. Crises are challenging for reasons which include: presentation with non-specific signs or symptoms, interaction of complex factors, progressive evolution, new situations, "revenge effects", inadequate assistance, and time constraints. In crises, clinicians often experience anxiety- and overload-induced performance degradation, tend to use "frequency gambling", run out of "rules" and have to work from first principles, and are prone to "confirmation bias". The effective management of crises requires formal training, usually simulator-based, and ideally in the inter-professional groups who will need to function as a team. "COVER ABCD-A SWIFT CHECK" is a pre-compiled algorithm which can be applied quickly and effectively to facilitate a systematic and effective response to the wide range of potentially lethal problems which may occur suddenly in anaesthesia. A set of 25 articles describing additional pre-compiled responses collated into a manual for the management of any crisis under anaesthesia has been published electronically as companion papers to this article. This approach to crisis management should be applied to other areas of clinical medicine as well as anaesthesia.

Preparation and Biological Evaluation of Radioiodinated Risperidone and Lamotrigine as Models for Brain Imaging

International Nuclear Information System (INIS)

Saddar, E.; El-Tawoosy, M.; Motaleb, H.A.

2014-01-01

Brain imaging technology is becoming an important tool in both research and clinical care. Due to the sensitivity of brain imaging technology, neuroscientists are able to visualize brain structure and function from the level of individual molecules to the whole brain, recognize and diagnose neurological disorders, develop new strategies for treatment and determine how therapies work. The study aimed to take advantages from drugs that are able to cross the brain barrier for the development of potential radiopharmaceuticals for non-invasive brain imaging. Risperidone and lamotrigine were successfully labeled with 125 I via direct electrophilic substitution reaction at 80 degree C. The reaction parameters affecting the preparation process were studied. 125 I-risperidone and 125 I-lamotrigine gave maximum labeling yield of 89 % ± 3.75 and 97.5 % ± 1.0 %, respectively and their stability were up to 6 and 24 h, respectively. Biodistribution studies showed that maximum uptake of 125 I-risperidone and 125 I-lamotrigine in the brain of mice were 4.27 % ± 0.38 and 2.45 % ± 0.18 of the injected activity/g tissue organ, at 10

Olanzapine induced Q-Tc shortening.

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Shoja Shafti, Saeed; Fallah Jahromi, Parisa

2014-12-01

Prolongation of Q-Tc interval is commonly accepted as a surrogate marker for the ability of a drug to cause torsade de pointes. In the present study, safety of olanzapine versus risperidone was compared among a group of patients with schizophrenia to see the frequency of the electrocardiographic alterations induced by those atypical antipsychotics. Two hundred and sixty-eight female inpatients with schizophrenia entered in one of the two parallel groups to participate in an open study for random assignment to olanzapine (n = 148) or risperidone (n = 120). Standard 12-lead surface electrocardiogram (ECG) was taken from each patient at baseline, before initiation of treatment, and then at the end of management, just before discharge. The parameters that were assessed included heart rate (HR), P-R interval, QRS interval, Q-T interval (corrected = Q-Tc), ventricular activation time (VAT), ST segment, T wave, axis of QRS, and finally, interventricular conduction process. A total of 37.83% of cases in the olanzapine group and 30% in the risperidone group showed some Q-Tc changes; 13.51% and 24.32% of the patients in the olanzapine group showed prolongation and shortening of the Q-Tc, respectively, while changes in the risperidone group were restricted to only prolongation of Q-Tc. Comparison of means showed a significant increment in Q-Tc by risperidone (p = 0.02). Also, comparison of proportions in the olanzapine group showed significantly more cases with shortening of Q-Tc versus its prolongation (p = 0.01). No significant alterations with respect to other variables were evident. Olanzapine and risperidone had comparable potentiality for induction of Q-Tc changes, while production of further miscellaneous alterations in ECG was more observable in the olanzapine group compared with the risperidone group. Also shortening of Q-Tc was specific to olanzapine.

Oil crises

International Nuclear Information System (INIS)

Linderoth, H.

1992-01-01

The author's aim was to give very precise information on the many causes and effects of the oil crises that have occurred since 1900, and at the same time offer the reader the possibility to build up a basic knowledge of the oil industry and market, as he feels that the public is often subjected to misleading information. Political and economical aspects are elaborated. First-hand sources such as statistics and investigations have been used as far as possible to give information on the oil market. An oil crisis is defined by the author as a significant change in the price of oil compared to prices of other goods. Changes can be in the form of either rising or falling prices. A special chapter concentrates on Denmark in relation to the oil crises. (AB) (165 refs.)

Systemic Crises and Growth

OpenAIRE

Romain Ranciere; Aaron Tornell; Frank Westermann

2005-01-01

In this paper, we document the fact that countries that have experienced occasional financial crises have, on average, grown faster than countries with stable financial conditions. We measure the incidence of crisis with the skewness of credit growth, and find that it has a robust negative effect on GDP growth. This link coexists with the negative link between variance and growth typically found in the literature. To explain the link between crises and growth we present a model where contract...

Effect of switching to risperidone after unsuccessful treatment with aripiprazole on plasma monoamine metabolites level in the treatment of acute schizophrenia.

Science.gov (United States)

Miura, Itaru; Takeuchi, Satoshi; Katsumi, Akihiko; Kanno, Keiko; Watanabe, Kenya; Mashiko, Hirobumi; Niwa, Shin-Ichi

2012-09-01

In the treatment of acute schizophrenia, risperidone and aripiprazole are both placed the first line antipsychotics. These two antipsychotics have different pharmacological effects. We investigated the effects of risperidone on plasma levels of homovanillic acid (HVA) and 3-methoxy-4hydroxyphenylglycol after unsuccessful aripiprazole treatment in acute schizophrenia. Ten Japanese patients with acute schizophrenia were enrolled to this study. Plasma levels of monoamine metabolites were analyzed with high-performance liquid chromatography with electrochemical detection. Risperidone improved the symptoms and 4 of 10 patients were responders. Risperidone showed a tendency to decrease plasma HVA (pHVA) levels in responders (p = 0.068), but not in non-responders (p = 1.0). At baseline, pHVA levels of responders were significantly higher than that of non-responders (p = 0.033). A trend for negative correlation was found between pHVA at baseline and the changes in Positive and Negative Syndrome Scale-Total (p = 0.061, r = -0.61). Our results suggest that high pHVA level before switching may predict good response to the second line antipsychotics after unsuccessful first antipsychotic treatment. If aripiprazole is not effective in acute schizophrenia, switching to risperidone may be effective and reasonable strategy for improving symptoms. Copyright © 2012 John Wiley & Sons, Ltd.

New Modified UPLC/Tandem Mass Spectrometry Method for Determination of Risperidone and Its Active Metabolite 9-Hydroxyrisperidone in Plasma: Application to Dose-Dependent Pharmacokinetic Study in Sprague-Dawley Rats

Directory of Open Access Journals (Sweden)

Essam Ezzeldin

2017-01-01

Full Text Available Sensitive and specific liquid-chromatography tandem mass spectrometry (UPLC-MS/MS assay has been developed and validated for simultaneous quantification of risperidone (RIS and its active metabolite 9-hydroxyrisperidone (9-OH-RIS in rat plasma using olanzapine (OLA as internal standard (IS. Pharmacokinetics of risperidone and its active metabolite 9-hydroxyrisperidone was compared across different doses (0.3, 1.0, and 6.0 mg/kg. Serial blood sample was collected over a time of 48 hours and analyzed for risperidone and its active metabolite 9-hydroxyrisperidone. The pharmacokinetics parameters including Cmax, tmax, and AUC were determined for risperidone and its active ingredient. The method was linear in the concentration range of 0.2–500 ng/mL for risperidone and 9-OH-risperidone, with coefficients of determination greater than 0.998 and lower limit of quantitation of 0.2 ng/mL. Blood levels of risperidone and its active metabolite were roughly dose-proportional. The method developed herein is simple and rapid and was successfully applied for dose-dependent pharmacokinetic study.

Gender trends in developing countries during financial crises

NARCIS (Netherlands)

I.P. van Staveren (Irene)

2010-01-01

textabstractThe paper looks at several financial crises in the past: the Asian financial crisis, the Brazilian, Argentine and Turkish financial crises, around the turn of the last century. Data are analyzed for a 10-year period around these crises. The data include gender indicators (mostly

Human resource crises in German hospitals--an explorative study.

Science.gov (United States)

Schermuly, Carsten C; Draheim, Michael; Glasberg, Ronald; Stantchev, Vladimir; Tamm, Gerrit; Hartmann, Michael; Hessel, Franz

2015-05-28

The complexity of providing medical care in a high-tech environment with a highly specialized, limited labour force makes hospitals more crisis-prone than other industries. An effective defence against crises is only possible if the organizational resilience and the capacity to handle crises become part of the hospitals' organizational culture. To become more resilient to crises, a raised awareness--especially in the area of human resource (HR)--is necessary. The aim of this paper is to contribute to the process robustness against crises through the identification and evaluation of relevant HR crises and their causations in hospitals. Qualitative and quantitative methods were combined to identify and evaluate crises in hospitals in the HR sector. A structured workshop with experts was conducted to identify HR crises and their descriptions, as well as causes and consequences for patients and hospitals. To evaluate the findings, an online survey was carried out to rate the occurrence (past, future) and dangerousness of each crisis. Six HR crises were identified in this study: staff shortages, acute loss of personnel following a pandemic, damage to reputation, insufficient communication during restructuring, bullying, and misuse of drugs. The highest occurrence probability in the future was seen in staff shortages, followed by acute loss of personnel following a pandemic. Staff shortages, damage to reputation, and acute loss of personnel following a pandemic were seen as the most dangerous crises. The study concludes that coping with HR crises in hospitals is existential for hospitals and requires increased awareness. The six HR crises identified occurred regularly in German hospitals in the past, and their occurrence probability for the future was rated as high.

Dopamine transporter density assessed with [{sup 123}]IPT SPECT before and after risperidone treatment in children with tourette's disorder

Energy Technology Data Exchange (ETDEWEB)

Ryu, Young Hoon; Kim, Tae Hoon; Ryu, Won Gee [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)] [and others

2004-02-01

Tourette's disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the dopamine transporter (DAT) densities between drug-naive children with TD and normal children, and investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using iodine-123 labelled N-(3-iodopropen-2-yl)-2{beta}-carbomethoxy-3beta-(4-chlorophenyl)tropane ([{sup 123}I]IPT) single photon emission computed tomography (SPECT). [{sup 123I}]IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in nine drug-naive children with TD. Eleven normal children also underwent SPECT imaging 2 hours after an intravenous administration of [{sup 123}I]IPT. Drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with risperidone in children with TD was found, although tic symptoms were significantly improved with risperidone. These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system.

Risperidone and Divalproex Differentially Engage the Fronto-Striato-Temporal Circuitry in Pediatric Mania: A Pharmacological Functional Magnetic Resonance Imaging Study

Science.gov (United States)

Pavuluri, Mani N.; Passarotti, Alessandra M.; Fitzgerald, Jacklynn M.; Wegbreit, Ezra; Sweeney, John A.

2012-01-01

Objective: The current study examined the impact of risperidone and divalproex on affective and working memory circuitry in patients with pediatric bipolar disorder (PBD). Method: This was a six-week, double-blind, randomized trial of risperidone plus placebo versus divalproex plus placebo for patients with mania (n = 21; 13.6 [plus or minus] 2.5…

Gender inequality in economic crises

Directory of Open Access Journals (Sweden)

Lina Gálvez Muñoz

2012-03-01

Full Text Available This article presents a historical analysis of the economic crises of the last hundred years from a feminist economics perspective, highlighting three historical patterns that can help to advance in a deeper understanding of the current crisis and, above all, to guarantee a way out of this crisis with more and not less equality. The first pattern is that crises result in an intensification of women's work, especially the unpaid care work. The second one is that after economic crises male employment recovery is always previous to the female employment, which always ends even more precarious; and the third pattern is that crisis lead to setbacks in the advances made in gender equality in terms of regulation, equality policies and the rules of the game in general.

The influence of risperidone on attentional functions in children and adolescents with attention-deficit/hyperactivity disorder and co-morbid disruptive behavior disorder.

Science.gov (United States)

Günther, Thomas; Herpertz-Dahlmann, Beate; Jolles, Jellemer; Konrad, Kerstin

2006-12-01

This study aims to examine the influence of risperidone on various attentional functions, including intensity and selectivity aspects of attention plus inhibitory control in children with attention deficit/hyperactivity disorder (ADHD) with co-morbid Disruptive Behavior Disorders (DBD) and normal IQ. Children with ADHD and DBD, aged 8-15 years, were treated with risperidone (mean daily dose: 1.5 mg; n = 23) and examined with three attentional paradigms before and after a 4-week treatment period. Age- and IQ-matched normal controls (n = 23) were also tested without medication on the same two occasions. No influence of the medication could be detected for any neuropsychological variable, neither as a positive enhancement nor as adverse side effects. However, clinical symptoms of ADHD and DBD assessed on the IOWA Conners Scale significantly improved after the 4-week treatment period. Divergent behavioral and cognitive effects of risperidone on ADHD symptoms were observed, with a significant reduction in behavioral symptoms, whereas no positive treatment effects were found on laboratory tasks of impulsivity. Thus, the cognitive effects of risperidone seem to differ from the cognitive effects of stimulant treatments in children with ADHD + DBD. However, no negative impact of risperidone was observed on attentional functions either, i.e., there was no slowing of cognitive speed.

Different mechanisms of risperidone result in improved interpersonal trust, social engagement and cooperative behavior in patients with schizophrenia compared to trifluoperazine.

Science.gov (United States)

Tse, Wai Shing; Wong, Ann Siu Wah; Chan, Fu; Pang, Alfred Hin Tat; Bond, Alyson Jane; Chan, Chau Kiu Raymond

2016-05-01

Atypical antipsychotic treatment (e.g. risperidone) has been found to improve social functioning more than standard antipsychotic treatment. However, it is unclear which specific social behaviors are implicated in this improvement. The current study employed an interactive puzzle game to examine how social behaviors contribute to the improvement of social functioning by comparing patients receiving risperidone with those receiving trifluoperazine. Scores on the Positive and Negative Syndrome Scale, executive functioning, and social functioning were obtained from 24 patients with schizophrenia receiving either risperidone (n = 12) or trifluoperazine (n = 12), before their social behavior was measured in the interactive Tangrams Game. Immediately after the Tangrams Game, participants filled in two questionnaires measuring their interpersonal trust and rejection toward their game partner. Patients receiving risperidone showed more social engagement, cooperative behavior and interpersonal trust toward their game partners than those receiving trifluoperazine. Additional multivariate analysis of variance revealed that lower affiliative behavior was a function of positive symptoms; interpersonal trust had an impact on social engagement but executive functioning did not explain lower interpersonal trust or social disengagement. Improvement of social competence by risperidone might be related to the enhancement of both social behaviors and interpersonal trust as well as better symptom resolution. © 2016 The Authors. Psychiatry and Clinical Neurosciences © 2016 Japanese Society of Psychiatry and Neurology.

Clozapine usage increases the incidence of pneumonia compared with risperidone and the general population: a retrospective comparison of clozapine, risperidone, and the general population in a single hospital over 25 months.

Science.gov (United States)

Stoecker, Zachary R; George, Wales T; O'Brien, Jeffrey B; Jancik, Jon; Colon, Eduardo; Rasimas, Joseph J

2017-05-01

The aim of this study was to determine whether the incidence of pneumonia in patients taking clozapine was more frequent compared with those taking risperidone or no atypical antipsychotics at all before admission to a tertiary care medical center. This was a retrospective, case-matched study of 465 general medicine patients over a 25 month period from 1 July 2010 to 31 July 2012. Detailed electronic medical records were analyzed to explore the association between the use of two atypical antipsychotics and incidence of pneumonia. Of the 155 patients in the clozapine group, 54 (34.8%) had documented pneumonia compared with 22 (14.2%) in the risperidone group and 18 (11.6%) in the general population group. Clozapine, when compared with the untreated general population, was associated with an increased risk of pneumonia (odds ratio=4.07; 95% confidence interval=2.25-7.36). There was, however, no significant increase in the risk of pneumonia associated with the use of risperidone (odds ratio=1.26; 95% confidence interval=0.65-2.45). Clozapine use is associated with increased risk of pneumonia that may be related to immunologic factors or side effects of sedation and drooling that make aspiration more likely, although causative mechanisms require further investigation. These findings suggest that providers should use added caution in choosing candidates for clozapine therapy.

Financial Stress Indices and Financial Crises

NARCIS (Netherlands)

Vermeulen, Robert; Hoeberichts, Marco; Vasicek, Borek; Zigraiova, Diana; Smidkova, Katerina; de Haan, Jakob

This paper develops a Financial Stress Index (FSI) for 28 OECD countries and examines its relationship to crises using a novel database for financial crises. A stress index measures the current state of stress in the financial system and summarizes it in a single statistic. Our results suggest that

Risperidone-Induced Weight Gain in Referred Children with Autism Spectrum Disorders Is Associated with a Common Polymorphism in the 5-Hydroxytryptamine 2C Receptor Gene

NARCIS (Netherlands)

Hoekstra, Pieter J.; Troost, Pieter W.; Lahuis, Bertine E.; Mulder, Hans; Mulder, Erik J.; Franke, Barbara; Buitelaar, Jan K.; Anderson, George M.; Scahill, Lawrence; Minderaa, Ruud B.

2010-01-01

Weight gain is an important adverse effect of risperidone, but predictors of significant weight gain have yet to be identified in pediatric patients. Here, we investigated differences between age-and gender-normed body mass index-standardized z scores at baseline and after 8 weeks of open-label,

The Social Costs of Financial Crises

NARCIS (Netherlands)

M.A. van Dijk (Mathijs)

2013-01-01

textabstractThis paper studies the impact of financial crises on society. Using data on 187 banking crises in 126 countries over the period 1970-2009, I examine the impact of a crisis not only on the economy and the financial sector, but also on health, education, poverty, and gender issues. A

Crises in Asia or crisis of globalisation?

OpenAIRE

Dieter, Heribert

1998-01-01

The crises in Southeast and East Asia have started a new round of debate on the benefits and disadvantages of globalisation. We have to ask whether the crises in Asia were the result of failures in national economic policy or whether they were the consequence of ill-constructed global financial markets. It can be concluded that the crises were caused by a number of factors, both internal and external, but that the decisive shifts came from actors on international financial markets as well as ...

Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology.

Science.gov (United States)

McDougle, Christopher J; Scahill, Lawrence; Aman, Michael G; McCracken, James T; Tierney, Elaine; Davies, Mark; Arnold, L Eugene; Posey, David J; Martin, Andrès; Ghuman, Jaswinder K; Shah, Bhavik; Chuang, Shirley Z; Swiezy, Naomi B; Gonzalez, Nilda M; Hollway, Jill; Koenig, Kathleen; McGough, James J; Ritz, Louise; Vitiello, Benedetto

2005-06-01

Risperidone has been found efficacious for decreasing severe tantrums, aggression, and self-injurious behavior in children and adolescents with autistic disorder (autism). The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior. The database from an 8-week double-blind, placebo-controlled trial (N=101) and 16-week open-label continuation study (N=63) of risperidone for children and adolescents with autism was used to test for drug effects on secondary outcome measures: scores on the Ritvo-Freeman Real Life Rating Scale, the Children's Yale-Brown Obsessive Compulsive Scale, and the maladaptive behavior domain of the Vineland Adaptive Behavior Scales. Compared to placebo, risperidone led to a significantly greater reduction in the overall score on the Ritvo-Freeman Real Life Rating Scale, as well as the scores on the subscales for sensory motor behaviors (subscale I), affectual reactions (subscale III), and sensory responses (subscale IV). No statistically significant difference was observed, however, on the subscale for social relatedness (subscale II) or language (subscale V). Risperidone also resulted in significantly greater reductions in scores on the Children's Yale-Brown Obsessive Compulsive Scale and Vineland maladaptive behavior domain. This pattern of treatment response was maintained for 6 months. Risperidone led to significant improvements in the restricted, repetitive, and stereotyped patterns of behavior, interests, and activities of autistic children but did not significantly change their deficit in social interaction and communication. Further research is necessary to develop effective treatments for the core social and communicative impairments of autism.

Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial.

Science.gov (United States)

Ghaleiha, Ali; Asadabadi, Mahtab; Mohammadi, Mohammad-Reza; Shahei, Maryam; Tabrizi, Mina; Hajiaghaee, Reza; Hassanzadeh, Elmira; Akhondzadeh, Shahin

2013-05-01

Autism is a neurodevelopmental disorder that causes significant impairment in socialization and communication. It is also associated with ritualistic and stereotypical behaviour. Recent studies propose both hyper-and hypoglutamatergic ideologies for autism. The objective of this study was to assess the effects of memantine plus risperidone in the treatment of children with autism. Children with autism were randomly allocated to risperidone plus memantine or placebo plus risperidone for a 10-wk, double-blind, placebo-controlled study. The dose of risperidone was titrated up to 3 mg/d and memantine was titrated to 20 mg/d. Children were assessed at baseline and after 2, 4, 6, 8 and 10 wk of starting medication protocol. The primary outcome measure was the irritability subscale of Aberrant Behavior Checklist-Community (ABC-C). Difference between the two treatment arms was significant as the group that received memantine had greater reduction in ABC-C subscale scores for irritability, stereotypic behaviour and hyperactivity. Eight side-effects were observed over the trial, out of the 25 side-effects that the checklist included. The difference between the two groups in the frequency of side-effects was not significant. The present study suggests that memantine may be a potential adjunctive treatment strategy for autism and it was generally well tolerated. This trial is registered with the Iranian Clinical Trials Registry (IRCT1138901151556N10; www.irct.ir).

Comparison of olanzapine and risperidone in the EMBLEM Study: translation of randomized controlled trial findings into clinical practice.

Science.gov (United States)

Novick, Diego; Reed, Catherine; Haro, Josep Maria; Gonzalez-Pinto, Ana; Perrin, Elena; Aguado, Jaume; Tohen, Mauricio

2010-09-01

Data from the EMBLEM Study, a 2-year, prospective, observational study of health outcomes associated with acute treatment of patients experiencing a manic/mixed episode of bipolar disorder, was used to compare the effectiveness of olanzapine monotherapy versus risperidone monotherapy, and to investigate whether the treatment effects were similar to those reported in a 3-week, randomized controlled trial assessing the same treatments. Symptom severity measures included the Young Mania Rating Scale (YMRS), the 5-item Hamilton Depression Rating Scale, and the Clinical Global Impression-Bipolar Disorder Scale. A total of 245 EMBLEM inpatients were analyzed with YMRS >or=20: olanzapine (n=209), risperidone (n=36). Both the treatment groups had similar improvements in YMRS from baseline to 6 weeks, but there was a significantly greater improvement in 5-item Hamilton Depression Rating Scale in the olanzapine group. There was a similar improvement in Clinical Global Impression-Bipolar Disorder Scale in both the groups and the occurrence of treatment-emergent adverse events and weight gain did not differ between the treatment groups. The EMBLEM results partly support those of the randomized controlled trial, which suggests olanzapine and risperidone have similar improvements in mania but that olanzapine monotherapy may be more effective than risperidone monotherapy in the treatment of depressive symptoms associated with mania. Limitations include differences in study design, patient population, and length of follow-up.

Movement disorders in elderly users of risperidone and first generation antipsychotic agents: a Canadian population-based study.

Directory of Open Access Journals (Sweden)

Irina Vasilyeva

Full Text Available Despite concerns over the potential for severe adverse events, antipsychotic medications remain the mainstay of treatment of behaviour disorders and psychosis in elderly patients. Second-generation antipsychotic agents (SGAs; e.g., risperidone, olanzapine, quetiapine have generally shown a better safety profile compared to the first-generation agents (FGAs; e.g., haloperidol and phenothiazines, particularly in terms of a lower potential for involuntary movement disorders. Risperidone, the only SGA with an official indication for the management of inappropriate behaviour in dementia, has emerged as the antipsychotic most commonly prescribed to older patients. Most clinical trials evaluating the risk of movement disorders in elderly patients receiving antipsychotic therapy have been of limited sample size and/or of relatively short duration. A few observational studies have produced inconsistent results.A population-based retrospective cohort study of all residents of the Canadian province of Manitoba aged 65 and over, who were dispensed antipsychotic medications for the first time during the time period from April 1, 2000 to March 31, 2007, was conducted using Manitoba's Department of Health's administrative databases. Cox proportional hazards models were used to determine the risk of extrapyramidal symptoms (EPS in new users of risperidone compared to new users of FGAs.After controlling for potential confounders (demographics, comorbidity and medication use, risperidone use was associated with a lower risk of EPS compared to FGAs at 30, 60, 90 and 180 days (adjusted hazard ratios [HR] 0.38, 95% CI: 0.22-0.67; 0.45, 95% CI: 0.28-0.73; 0.50, 95% CI: 0.33-0.77; 0.65, 95% CI: 0.45-0.94, respectively. At 360 days, the strength of the association weakened with an adjusted HR of 0.75, 95% CI: 0.54-1.05.In a large population of elderly patients the use of risperidone was associated with a lower risk of EPS compared to FGAs.

Celecoxib as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial.

Science.gov (United States)

Asadabadi, Mahtab; Mohammadi, Mohammad-Reza; Ghanizadeh, Ahmad; Modabbernia, Amirhossein; Ashrafi, Mandana; Hassanzadeh, Elmira; Forghani, Saeedeh; Akhondzadeh, Shahin

2013-01-01

Autism is associated with activation of the inflammatory response system. This study aims to assess the efficacy of a cyclooxygenase-2 inhibitor, celecoxib, as adjunctive therapy in the treatment of autism In a 10-week randomized double-blind placebo-controlled study, 40 outpatient children with a Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision clinical diagnosis of autism were randomly allocated to celecoxib plus risperidone or placebo plus risperidone. The dose of risperidone and celecoxib were titrated up to 3 and 300 mg/day, respectively. Patients were assessed at baseline and after 2, 4, 6, and 10 weeks of starting medication using the Aberrant Behavior Checklist-Community (ABC-C) Rating Scale. Primary outcome measure was the change in irritability subscale of ABC-C. Significant time × treatment interaction was observed for Irritability (F (1.658, 63.021) = 13.580, P autism. (Registration, www.irct.ir ; IRCT138711091556N2).

Identifying product development crises: The potential of adaptive heuristics

DEFF Research Database (Denmark)

Münzberger, C.; Stingl, Verena; Oehmen, Josef

2017-01-01

This paper introduces adaptive heuristics as a tool to identify crises in design projects and highlights potential applications of these heuristics as decision support tool for crisis identification. Crises may emerge slowly or suddenly, and often have ambiguous signals. Thus the identification...... for the application of heuristics in design sciences. To achieve this, the paper compares crises to 'business as usual', and presents sixteen indicators for emerging crises. These indicators are potential cues for adaptive heuristics. Specifically three adaptive heuristics, One-single-cue, Fast-and-Frugal-Trees...

Industry Specifics and Consumers’ Reactions to Business Crises

Directory of Open Access Journals (Sweden)

Kazlauskienė Asta

2018-02-01

Full Text Available Different scientific studies provide many valuable recommendations how to manage crises in order to lessen their negative effect on relations with consumers. But the question whether the same business crises management rules can be applied for different industries, or they must be adapted depending on industries specifics, has not received sufficient scientific attention. Knowledge gaps about industry specific effect on consumer reactions to business crises remain. This study focuses on understanding the differences in consumers’ reactions in business crises situations with regard to controversial evaluation in the society of “the sin industries” (alcohol, tobacco, gambling, etc. and ordinary industries (not having controversial associations. Experimental research design, including online experiment with tobacco, beer and functional soft drinks consumers (in total 306 respondents, was chosen for competing research hypotheses testing. Empirical evidence was in line with theoretical argumentation about less negative consumers’ reactions during business crises in case of “sin industries” versus ordinary industry. This study shows that consumers attitudes, such as perception of company’s product quality, trust, social responsibility and behavioural intentions, such as intention to buy and recommend company’s products, are less negative during business crises in lower reputation “sin industries” than in ordinary industries.

No change of dopamine transporter density in basal ganglia after risperidone treatment in drug-naive children with Tourette's disorder

International Nuclear Information System (INIS)

Ryu, W. K.; Ryu, Y. H.; Yoon, M. J.; Chun, K. A.; Lee, J. D.; Zee, D. Y.; Choi, T. H.

2003-01-01

Tourette's disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the DAT densities between drug-naive children with TD and normal children investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using lodine-123 labelled N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane(I-123 IPT) single photon emission computed tomography (SPECT). I-123 IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in eight drug-naive children with TD. Eight normal children also underwent SPECT imaging 2 hours after an intravenous administration of I-123 IPT and carried out both quantitative and qualitative analyses using the obtained SPECT data, which were reconstructed for the assessment of the specific/non-specific DAT binding ratio in the basal ganglia. The drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with riperidone in children with TD was not found, although tic symptoms were significantly improved with risperidone. These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system

Banking Crises and Bank Resolution; Experiences in Some Transition Economies

OpenAIRE

International Monetary Fund

2002-01-01

Like most transition economies, Bulgaria, Lithuania, and Mongolia suffered severe banking crises, which had to be resolved before growth could resume. The macroeconomic and institutional failings that led to these crises are described, and parallels are drawn with the causes of banking crises in industrial and developing countries. Resolving the crises proved technically and politically difficult, and setbacks occurred. Successful resolution required the implementation of a comprehensive and ...

Bioequivalence study of a generic Risperidone (Iperdal® in healthy Thai male volunteers

Directory of Open Access Journals (Sweden)

Werawath Mahatthanatrakul

2008-05-01

Full Text Available The objective of this study was to compare the rate and extent of absorption of a generic risperidone (Iperdal® with a reference formulation (Risperdal® when given orally. The study was an open label, randomized, two-period, two-sequence,single dose cross-over design with a 2 weeks washout period in 16 healthy Thai male volunteers. Single oral dose of two 2-mg tablets of risperidone were administered and serial blood samples were collected from the antecubital vein before and at0.17, 0.33, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0, 12, 24 and 48 hours post dose. Risperidone plasma concentrations were assayed using a validated High Performance Liquid Chromatographic (HPLC-UV method modified from Avenosoet al. (2000. Pharamcokinetic parameters i.e. Cmax, AUC0à48 and Tmax were analyzed by noncompartment analysis. Variations of the data were analyzed by “Two Way Analysis of Variance” (ANOVA. Statistics were tested as stated in USP 28 guidelinefor bioequivalence study. The maximum concentration (Cmax, ng/ml of risperidone for the innovator and the generic product were 31.11±17.24 (range 5.64-56.78 and 32.58±19.77 (range 5.29-84.56 ng/ml, respectively. The area under theplasma concentration-time curve (AUC0®48 of the innovator and the generic product were 160.64±152.89 (range 18.57- 550.32 and 144.03±127.37 (range 16.27-456.0 ng.hr/ml, respectively. The time to maximum concentration (Tmax of theinnovator and the generic product were 0.97±0.41(range 0.5-2 and 1.02±0.32 (range 0.5-1.5 hr, respectively. The 90% confidence interval of the ratio of the ln-transformed of Cmax and AUC0à48 of both preparations were 89.39-112.99% and80.02-107.28% respectively which were within the acceptance range of 80.00-125.00%. Therefore, it can be concluded that both preparations used in this study are bioequivalent in terms of both the rate and extent of absorption.

Risperidone in Children and Adolescents with Conduct Disorder: A Single-Center, Open-Label Study

OpenAIRE

Ercan, Eyüp Sabri; Kutlu, Ayşe; Çıkoğlu, Sibel; Veznedaroğlu, Baybars; Erermiş, Serpil; Varan, Azmi

2003-01-01

Background: Risperidone is one of the most commonly used atypical antipsychotic drugs in the treatment of children and adolescents. However, the data about its use in children and adolescents with conduct disorder (CD) are limited.

A comparison of risperidone and haloperidol for the risk of ischemic stroke in the elderly: a propensity score-matched cohort analysis.

Science.gov (United States)

Shin, Ju-Young; Choi, Nam-Kyong; Lee, Joongyub; Park, Mi-Ju; Lee, Shin Haeng; Park, Byung-Joo

2015-08-01

With an increase in antipsychotic use in the elderly, the safety profile of antipsychotics has been emphasized. Strong concerns have been raised about whether the risk of ischemic stroke differs between risperidone and haloperidol. This study compared the risk of ischemic stroke between elderly patients taking risperidone and haloperidol. We conducted a retrospective cohort study using the Korea Health Insurance Review and Assessment Service database, applying a propensity-matched analysis. The cohort consisted of elderly patients who were newly prescribed haloperidol or risperidone between January 1, 2006 and December 31, 2009. Patients with prior cerebrovascular diseases (ICD-10, I60-I69), transient ischemic attack (ICD-10, G45), or cerebral tumors (ICD-10, C31) during 365 days prior to the initiation date were excluded. The study subjects were selected by propensity score matching. The outcome was defined as the first hospitalization for ischemic stroke (ICD-10, I63). Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence intervals (95% CI) for ischemic stroke with haloperidol compared with risperidone use. A total of 14,103 patients were included in the propensity-matched cohort for each drug. Overall, the incidence rate was higher for haloperidol users compared to the risperidone users (6.43 per 1000 person-years vs. 2.88 per 1000 person-years). A substantially increased risk was observed in haloperidol users (adjusted HR = 2.02, 95% CI, 1.12-3.62). The evidence showed that haloperidol should be prescribed in the elderly with caution. © The Author(s) 2015.

Effects of risperidone on core symptoms of autistic disorder based on childhood autism rating scale: an open label study.

Science.gov (United States)

Ghaeli, Padideh; Nikvarz, Naemeh; Alaghband-Rad, Javad; Alimadadi, Abbas; Tehrani-Doost, Mehdi

2014-01-01

The aim of the present study was to evaluate the effect of risperidone in patients afflicted by autistic disorder especially with regards to its three core symptoms, including "relating to others", "communication skills", and "stereotyped behaviors" based on Childhood Autism Rating Scale (CARS). An 8-week open-label study of risperidone for treatment of autistic disorder in children 4-17 years old was designed. Risperidone dose titration was as follow: 0.02 mg/kg/day at the first week, 0.04 mg/kg/day at the second week, and 0.06 mg/kg/day at the third week and thereafter. The outcome measures were scores obtained by CARS, Aberrant Behavior Checklist (ABC), and Clinical Global Impression-Improvement (CGI-I) scale. Fifteen patients completed this study. After 8 weeks, CARS total score decreased significantly, (P=0.001). At the end of the study, social interactions and verbal communication skills of the patients were significantly improved (Pautistic disorder.

Efficacy of Oral Risperidone, Haloperidol, or Placebo for Symptoms of Delirium Among Patients in Palliative Care: A Randomized Clinical Trial.

Science.gov (United States)

Agar, Meera R; Lawlor, Peter G; Quinn, Stephen; Draper, Brian; Caplan, Gideon A; Rowett, Debra; Sanderson, Christine; Hardy, Janet; Le, Brian; Eckermann, Simon; McCaffrey, Nicola; Devilee, Linda; Fazekas, Belinda; Hill, Mark; Currow, David C

2017-01-01

Antipsychotics are widely used for distressing symptoms of delirium, but efficacy has not been established in placebo-controlled trials in palliative care. To determine efficacy of risperidone or haloperidol relative to placebo in relieving target symptoms of delirium associated with distress among patients receiving palliative care. A double-blind, parallel-arm, dose-titrated randomized clinical trial was conducted at 11 Australian inpatient hospice or hospital palliative care services between August 13, 2008, and April 2, 2014, among participants with life-limiting illness, delirium, and a delirium symptoms score (sum of Nursing Delirium Screening Scale behavioral, communication, and perceptual items) of 1 or more. Age-adjusted titrated doses of oral risperidone, haloperidol, or placebo solution were administered every 12 hours for 72 hours, based on symptoms of delirium. Patients also received supportive care, individualized treatment of delirium precipitants, and subcutaneous midazolam hydrochloride as required for severe distress or safety. Improvement in mean group difference of delirium symptom score (severity range, 0-6) between baseline and day 3. Five a priori secondary outcomes: delirium severity, midazolam use, extrapyramidal effects, sedation, and survival. Two hundred forty-seven participants (mean [SD] age, 74.9 [9.8] years; 85 women [34.4%]; 218 with cancer [88.3%]) were included in intention-to-treat analysis (82 receiving risperidone, 81 receiving haloperidol, and 84 receiving placebo). In the primary intention-to-treat analysis, participants in the risperidone arm had delirium symptom scores that were significantly higher than those among participants in the placebo arm (on average 0.48 Units higher; 95% CI, 0.09-0.86; P = .02) at study end. Similarly, for those in the haloperidol arm, delirium symptom scores were on average 0.24 Units higher (95% CI, 0.06-0.42; P = .009) than in the placebo arm. Compared with placebo, patients in both

The Many Crises of Western Journalism

DEFF Research Database (Denmark)

Nielsen, Rasmus Kleis

of professional journalism in existential terms; the second focuses on the weaknesses of the professional model itself; the third defines the crisis in symbolic terms, as a morally problematic relation among journalists, citizens, and power holders. These three crisis frameworks raise different questions...... and professionally relatively robust countries like Finland and Germany, where symbolic issues loom large; to countries like the US, where economic, professional, and symbolic crises seem to coincide -- and are interpreted in large part through the lens of technology; to countries like France, Italy, and the UK......, where crises are seen to coincide but where the roots of crises are seen as predating the rise of the internet and the erosion of existing business models for journalism. Each interpretation of the crisis in Western journalism points to different solutions, from appeals to state intervention in several...

Clinical and pharmacokinetic evaluation of risperidone for the management of autism spectrum disorder

NARCIS (Netherlands)

Dinnissen, Mariken; Dietrich, Andrea; van den Hoofdakker, Barbara J.; Hoekstra, Pieter J.

Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is often accompanied by psychiatric comorbidity. Although there is no medication currently available to treat the core symptoms of ASD, risperidone was the first drug to be approved for use in ASD and is still the

An Exploratory Study of Crises in Product Development

DEFF Research Database (Denmark)

Muenzberg, Christopher; Gericke, K.; Oehmen, Josef

2016-01-01

, which leads to the absence of crisis-specific design support [Münzberg et al.2015]. We conducted an explorative interview study to address the first research question. In this study 15 experienced design engineers were interviewed about their experiences with crises. We documented their understanding...... the interview results, by reflecting them against product development success factors [Gericke et al. 2013]. We propose these as a design support tool for crises, which is suitable for industrial practice. By answering the two questions, this paper contributes to theory by identifying "context factors", which...... of the interview study. In Section 4, crises are characterised and example situations are presented. Section 5 focuses on success factors. Section 6 closes with a discussion and conclusion, examining the answers to the research questions and developing a novel definition of crises in product development....

Forecasting potential crises

International Nuclear Information System (INIS)

Neufeld, W.P.

1984-01-01

Recently, the Trend Analysis Program (TAP) of the American Council of Life Insurance commissioned the Futures Group of Glastonbury, Connecticut, to examine the potential for large-scale catastrophic events in the near future. TAP was specifically concerned with five potential crises: the warming of the earth's atmosphere, the water shortage, the collapse of the physical infrastructure, the global financial crisis, and the threat of nuclear war. We are often unprepared to take action; in these cases, we lose an advantage we might have otherwise had. This is the whole idea behind forecasting: to foresee possibilities and to project how we can respond. If we are able to create forecasts against which we can test policy options and choices, we may have the luxury of adopting policies ahead of events. Rather than simply fighting fires, we have the option of creating a future more to our choosing. Short descriptions of these five potential crises and, in some cases, possible solutions are presented

Tic Reduction with Risperidone Versus Pimozide in a Randomized, Double-Blind, Crossover Trial

Science.gov (United States)

Gilbert, Donald L.; Batterson, J. Robert; Sethuraman, Gopalan; Sallee, Floyd R.

2004-01-01

Objective: To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders. Method: This was a randomized, double-blind, crossover (evaluable patient analysis) study. Nineteen children aged 7 to 17 years with Tourette's or chronic…

Financial crises: A culture of complacency

OpenAIRE

Tucker, J.

2010-01-01

The aim of this paper is to consider the role of complacency in financial crises over the last two decades, with a closer look at the ongoing Subprime Mortgage Financial Crisis. The theme of complacency and the concept of financial crisis are both explored. Financial crises are better understood by explaining their economic drivers and the fundamental role of complacency in the various transmission mechanisms involved. These drivers are then illustrated by means of recent selected financial c...

No change of dopamine transporter density in basal ganglia after risperidone treatment in drug-naive children with Tourette's disorder

Energy Technology Data Exchange (ETDEWEB)

Ryu, W. K.; Ryu, Y. H.; Yoon, M. J.; Chun, K. A.; Lee, J. D. [College of Medicine, Univ. of Yonsei, Seoul (Korea, Republic of); Zee, D. Y. [Univ. of Inhwa, Incheon (Korea, Republic of); Choi, T. H. [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

2003-07-01

Tourette's disorder (TD), which is characterized by multiple waxing and waning motor tics and one or more vocal tics, is known to be associated with abnormalities in the dopaminergic system. To testify our hypothesis that risperidone would improve tic symptoms of TD patients through the change of the dopaminergic system, we measured the DAT densities between drug-naive children with TD and normal children investigated the DAT density before and after treatment with risperidone in drug-naive children with TD, using lodine-123 labelled N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane(I-123 IPT) single photon emission computed tomography (SPECT). I-123 IPT SPECT imaging and Yale Global Tic Severity Scale-Korean version (YGTSS-K) for assessing the tic symptom severity were carried out before and after treatment with risperidone for 8 weeks in eight drug-naive children with TD. Eight normal children also underwent SPECT imaging 2 hours after an intravenous administration of I-123 IPT and carried out both quantitative and qualitative analyses using the obtained SPECT data, which were reconstructed for the assessment of the specific/non-specific DAT binding ratio in the basal ganglia. The drug-naive children with TD had a significantly greater increase in the specific/nonspecific DAT binding ratio of both basal ganglia compared with the normal children. However, no significant difference in the specific/nonspecific DAT binding ratio of the basal ganglia before and after treatment with riperidone in children with TD was not found, although tic symptoms were significantly improved with risperidone. These findings suggest that DAT densities are directly associated with the pathophysiology of TD, however, that the effect of risperidone on tic symptoms in children with TD is not attributed to the change of dopaminergic system.

Human resource crises in German hospitals?an explorative study

OpenAIRE

Schermuly, Carsten C; Draheim, Michael; Glasberg, Ronald; Stantchev, Vladimir; Tamm, Gerrit; Hartmann, Michael; Hessel, Franz

2015-01-01

Background The complexity of providing medical care in a high-tech environment with a highly specialized, limited labour force makes hospitals more crisis-prone than other industries. An effective defence against crises is only possible if the organizational resilience and the capacity to handle crises become part of the hospitals? organizational culture. To become more resilient to crises, a raised awareness?especially in the area of human resource (HR)?is necessary. The aim of this paper is...

Managing Mental Health Crises of Foreign College Students.

Science.gov (United States)

Oropeza, Barbara A. Clark; And Others

1991-01-01

Notes that student services professionals manage a number of mental health crises as part of their job responsibilities. Examines some issues that arise from assisting foreign college students experiencing such crises, with special focus on psychiatric committal, withdrawal from school, and return to the home country. (Author)

Communication crisis and its solution through crises management

Directory of Open Access Journals (Sweden)

Nicoleta DĂNESCU

2011-06-01

Full Text Available Crises are never convenient as they are destructive. Any institution or organization may face a crisis situation, able to endanger its normal activity and reputation. Some crises are predictable and can be prevented, others cannot be grasped and thus prevented. Experience proved that, despite all technical, economical, financial or educational cautions taken to stop or control a crisis, it can get out of control and develop. In these circumstances, the crisis can bring serious prejudices to the organization if not properly managed from all points of view. Communication during crisis is extremely important, aiming at generating changes and taking action against the crisis. Above all, crises management consists in interpersonal relations. Management activity in crises situations develops a constant and complex communication process with the aid of which, the manager, the crisis cell, the entire staff interact in order to find the optimal strategies to survive the crisis situation.

Risperidone treatment for ADHD in children and adolescents with bipolar disorder

OpenAIRE

Biederman, Joseph

2008-01-01

Joseph Biederman, Paul Hammerness, Robert Doyle, Gagan Joshi, Megan Aleardi, Eric MickPediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, MA, USAObjective: Children and adolescents with bipolar disorder are also at high risk of having comorbid attention-deficit hyperactivity disorder (ADHD). The objective of this study was to estimate improvement in ADHD symptoms in children with bipolar disorder.Methods: This was an open-label, study of risperidone monot...

Nouvelles analyses des crises alimentaires en Afrique de l'Ouest

Directory of Open Access Journals (Sweden)

Janin, P.

2015-01-01

Full Text Available New analyses of food crises in West Africa. The issue of crisis is a central element of debate and a strategic challenge for all stakeholders in West Africa. Food and nutrition crises are recurrent in the region, with a level of intensity and high variability constituting renewed challenges. The definition, delimitation and management of these crises are provided by an established and structured professional field, which favors intervention. Different conceptual and contextual approaches can be mobilized to account for the diversity and complexity of food and nutrition crises. Some more descriptive approaches list the causes and manifestations of these crises, while others insist on the fact that they are created, and identify their dynamic as being linked to interactions between various phenomena. To date, most of the various institutional actors involved in addressing food and nutrition crises, both at national and international levels, have favored the gradual improvement of expert systems providing technical short-term responses. In parallel, this has led to a harmonization of these frameworks of thought, which has been detrimental to the consideration of the diversity of questions and the integration of non-institutional actors. These are the boundaries and limitations that this article aims to question, in order to reinvoke the political dimension of the management of food crises (and their eventual resolution.

Effects of a novel, selective, sigma1-ligand, MS-377, on phencyclidine-induced behaviour.

Science.gov (United States)

Takahashi, S; Takagi, K; Horikomi, K

2001-07-01

Phencyclidine (PCP)-induced head-weaving is inhibited by a novel selective sigma1-ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377), but not by dopamine D2 antagonists. In the present study, we examined the effects of two potent and selective sigma1-ligands, MS-377 and N,N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl) ethylamine (NE-100), on PCP-induced rearing behaviour, hyperlocomotion and ataxia in comparison with the currently available antipsychotic agents with affinity for D2 receptors, haloperidol, sultopride and risperidone. Male Wistar rats or ddY mice were administered MS-377, NE-100, haloperidol, sultopride or risperidone, and PCP was administered 60 min later (in the case of NE-100 10 min later). Rearing behaviour, hyperlocomotion and ataxia were examined 10 min after PCP administration. MS-377, haloperidol, sultopride and risperidone dose-dependently inhibited PCP-induced rearing and hyperlocomotion, but did not antagonize PCP-induced ataxia. In contrast, the other selective sigma1-ligand, NE-100, did not affect any of the PCP-induced behaviour patterns in this study. These results suggest that there are at least two types of ligands for sigma1-receptors and that some sigma1-ligands, including MS-377, have more comprehensive effects against PCP-induced abnormal behaviour than other sigma1-ligands or D2 antagonists.

Weight changes and their associations with demographic and clinical characteristics in risperidone maintenance treatment for schizophrenia.

Science.gov (United States)

Xiang, Y-T; Wang, C-Y; Ungvari, G S; Kreyenbuhl, J A; Chiu, H F K; Lai, K Y C; Lee, E H M; Bo, Q-J; Dixon, L B

2011-06-01

This study aimed to characterize weight changes in schizophrenia patients taking risperidone as part of a randomized, controlled, open-label clinical trial. A total of 374 patients with schizophrenia who had been clinically stabilized following an acute episode were randomly assigned to a 'no-dose-reduction' group (initial optimal therapeutic doses continued throughout the study), a '4-week group' (initial optimal therapeutic doses continued for 4 weeks followed by a half dose reduction that was maintained until the end of the study) or a '26-week group' (initial optimal therapeutic doses continued for 26 weeks followed by a half dose reduction until the end of the study). Participants were assessed monthly using standardized assessment instruments during the first 6 months, and then every 2 months until the last recruited patient completed the 1-year follow-up. Weight gain was defined as gaining at least 7% of initial body weight, weight loss as losing at least 7% of initial body weight. A BMI weight loss compared to being normal weight. No correlation was found between weight change and dose reduction. Weight change is a common, long-term, but heterogeneous side effect in risperidone maintenance treatment for stable schizophrenia patients. Special attention should be paid to fluctuations in weight that may occur throughout the course of treatment with risperidone. © Georg Thieme Verlag KG Stuttgart · New York.

Different effects of paliperidone and risperidone therapy on blood lipid and Hcy metabolism as well as endocrine hormones in patients with schizophrenia

OpenAIRE

Bei-Fang Fan; Ze-Hui Li; Shuo Yang; Cai-Hong Gao

2017-01-01

Objective: To explore the different effects of paliperidone and risperidone therapy on blood lipid and Hcy metabolism as well as endocrine hormones in patients with schizophrenia. Methods: A total of 118 patients with schizophrenia who were treated in the hospital between December 2014 and February 2017 were collected as the research subjects and divided into control group and study group by random number table, each group with 59 cases. Control group received risperidone thera...

Delineating the GRIN1 phenotypic spectrum

DEFF Research Database (Denmark)

Lemke, Johannes R; Geider, Kirsten; Helbig, Katherine L

2016-01-01

consequences of GRIN1 mutations were investigated in Xenopus laevis oocytes. RESULTS: We identified heterozygous de novo GRIN1 mutations in 14 individuals and reviewed the phenotypes of all 9 previously reported patients. These 23 individuals presented with a distinct phenotype of profound developmental delay......, severe intellectual disability with absent speech, muscular hypotonia, hyperkinetic movement disorder, oculogyric crises, cortical blindness, generalized cerebral atrophy, and epilepsy. Mutations cluster within transmembrane segments and result in loss of channel function of varying severity...... impairment as well as oculomotor and movement disorders being discriminating phenotypic features. Loss of NMDA receptor function appears to be the underlying disease mechanism. The identification of both heterozygous and homozygous mutations blurs the borders of dominant and recessive inheritance of GRIN1...

FOREIGN DIRECT INVESTMENTS DURING FINANCIAL CRISES

Directory of Open Access Journals (Sweden)

VINTILA DENISIA MARIANA

2011-12-01

Full Text Available The fundamental idea of International capital flows is that short-term flows can be easily reversed, while flows on a longer time horizon are more stable. Crises are associated with withdrawals of short-term capital flows and growth of the foreign direct investment flows. The current crisis has meant a major decline of international capital flows, also of the foreign direct investment. The analysis in this article tries to establish if and under which conditions foreign direct investments can bring greater stability during the crisis, comparing the evolution of foreign direct investments in the current crisis with their response in previous crises. We show that during previous crises foreign direct investments were stable, behaving differently from other types of capital. Yet, during the current crisis, foreign direct investments have proven to be not so stable and all the components declined, raising questions about the resumption of the positive trend. The stability of foreign direct investments in the past was given by the increase of mergers and acquisitions during the crisis, reflecting fire-sale FDI. This feature is not found in the current crisis as mergers and acquisitions were severe affected by the crises and recorded a major decline. The current paper is realized in the doctoral program entitled PhD in economics at the standards of European knowledge- DoEsEc, scientific coordinator Prof. PhD Rodica Zaharia, institution The Academy of Economic Studies Bucharest, Faculty of International Business, period of research 2009-2012.

Anti-depressive effectiveness of olanzapine, quetiapine, risperidone and ziprasidone: a pragmatic, randomized trial

Directory of Open Access Journals (Sweden)

Løberg Else-Marie

2011-08-01

Full Text Available Abstract Background Efficacy studies indicate anti-depressive effects of at least some second generation antipsychotics (SGAs. The Bergen Psychosis Project (BPP is a 24-month, pragmatic, industry-independent, randomized, head-to-head comparison of olanzapine, quetiapine, risperidone and ziprasidone in patients acutely admitted with psychosis. The aim of the study is to investigate whether differential anti-depressive effectiveness exists among SGAs in a clinically relevant sample of patients acutely admitted with psychosis. Methods Adult patients acutely admitted to an emergency ward for psychosis were randomized to olanzapine, quetiapine, risperidone or ziprasidone and followed for up to 2 years. Participants were assessed repeatedly using the Positive and Negative Syndrome Scale - Depression factor (PANSS-D and the Calgary Depression Scale for Schizophrenia (CDSS. Results A total of 226 patients were included. A significant time-effect showing a steady decline in depressive symptoms in all medication groups was demonstrated. There were no substantial differences among the SGAs in reducing the PANSS-D score or the CDSS sum score. Separate analyses of groups with CDSS sum scores > 6 or ≤6, respectively, reflecting degree of depressive morbidity, revealed essentially identical results to the primary analyses. There was a high correlation between the PANSS-D and the CDSS sum score (r = 0.77; p Conclusions There was no substantial difference in anti-depressive effectiveness among olanzapine, quetiapine, risperidone or ziprasidone in this clinically relevant sample of patients acutely admitted to hospital for symptoms of psychosis. Based on our findings we can make no recommendations concerning choice of any particular SGA for targeting symptoms of depression in a patient acutely admitted with psychosis. Trial Registration ClinicalTrials.gov ID; URL: http://www.clinicaltrials.gov/: NCT00932529

Do Economic Reforms Alleviate Subjective Well-Being Losses of Economic Crises?

DEFF Research Database (Denmark)

Bjørnskov, Christian

2014-01-01

Major economic crises tend to be followed by crises in subjective well-being. Following the financial and debt crises, politicians and social scientists have engaged in heated discussions of ways to alleviate such losses. In particular, should governments intervene more or less? This paper explores...... whether liberalizing economic institutions, a type of reform favoured by some economists, is likely to alleviate such loses. Estimating the effects of crises across European states 1975–2011 suggest that countries with relatively easy market regulations suffered smaller well-being losses....

Treatment-completion rates with olanzapine long-acting injection versus risperidone long-acting injection in a 12-month, open-label treatment of schizophrenia: indirect, exploratory comparisons

Directory of Open Access Journals (Sweden)

Ascher-Svanum H

2012-05-01

Full Text Available Haya Ascher-Svanum1, William S Montgomery2, David P McDonnell3, Kristina A Coleman4, Peter D Feldman11Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA; 2Eli Lilly Australia Pty Ltd, West Ryde, New South Wales, Australia; 3Eli Lilly and Company, Cork, Ireland; 4OptumInsight, Lilyfield, New South Wales, AustraliaBackground: Little is known about the comparative effectiveness of atypical antipsychotics in long-acting injection formulation. Due to the absence of head-to-head studies comparing olanzapine long-acting injection and risperidone long-acting injection, this study was intended to make exploratory, indirect, cross-study comparisons between the long-acting formulations of these two atypical antipsychotics in their effectiveness in treating patients with schizophrenia.Methods: Indirect, cross-study comparisons between olanzapine long-acting injection and risperidone long-acting injection used 12-month treatment-completion rates, because discontinuation of an antipsychotic for any cause is a recognized proxy measure of the medication's effectiveness in treating schizophrenia. Following a systematic review of the literature, two indirect comparisons were conducted using open-label, single-cohort studies in which subjects were stabilized on an antipsychotic medication before depot initiation. The first analysis compared olanzapine long-acting injection (one study with pooled data from nine identified risperidone long-acting injection studies. The second analysis was a “sensitivity analysis,” using only the most similar studies, one for olanzapine long-acting injection and one for risperidone long-acting injection, which shared near-identical study designs and involved study cohorts with near-identical patient characteristics. Pearson Chi-square tests assessed group differences on treatment-completion rates.Results: Comparison of olanzapine long-acting injection data (931 patients with the pooled data from the nine

Dopamine D2 receptor occupancy by olanzapine or risperidone in young patients with schizophrenia

NARCIS (Netherlands)

Lavalaye, J.; Linszen, D. H.; Booij, J.; Reneman, L.; Gersons, B. P.; van Royen, E. A.

1999-01-01

A crucial characteristic of antipsychotic medication is the occupancy of the dopamine (DA) D2 receptor. We assessed striatal DA D2 receptor occupancy by olanzapine and risperidone in 36 young patients [31 males, 5 females; mean age 21.1 years (16-28)] with first episode schizophrenia, using

Synthesis, recognition and evaluation of molecularly imprinted polymer nanoparticle using miniemulsion polymerization for controlled release and analysis of risperidone in human plasma samples

International Nuclear Information System (INIS)

Asadi, Ebadullah; Azodi-Deilami, Saman; Abdouss, Majid; Kordestani, Davood; Rahimi, Alireza; Asadi, Somayeh

2014-01-01

We prepared high selective imprinted nanoparticle polymers by a miniemulsion polymerization technique, using risperidone as the template, MAA as the functional monomers, and TRIM as the cross-linker in acetonitrile as solvent. The morphology of the nanoparticles determined by scanning electron microscopy (SEM) images and drug release, binding properties and dynamic light scattering (DLS) of molecularly imprinted polymers (MIPs) were studied. Controlled release of risperidone from nanoparticles was investigated through in 1% wt sodium dodecyl sulfate aqueous solution and by measuring the absorbance by HPLC-UV. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles, which contributed to interaction of risperidone with imprinted cavities within nanoparticles. Furthermore, the results from HPLC showed good precision (5% for 50.0 µg L -1 ) and recoveries (between 86-91) using MIP from human plasma samples

EPISTEMOLOGIA AMBIENTAL: A crise ambiental como uma crise da razão

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Matheus Silva De Gregori

2013-04-01

Full Text Available O presente estudo tem como objetivo analisar a crise do meio ambiente sob uma abordagem epistemológica, ou seja, a partir do conhecimento produzido em relação à natureza. Verifica-se que o pensamento ocidental, manifestado pelos paradigmas da Ciência Moderna, está ligado à organização dos sistemas econômicos que reconheceram historicamente a natureza apenas como recurso e potencial de produção de capital, vindo a encontrar, por esta via, o limite entrópico da biosfera e, por conseguinte, do crescimento. Abordou-se o processo de construção do conhecimento, questionando-se a possibilidade de concepção de outras perspectivas, fundadas na inseparabilidade entre sujeito-objeto, ação-pensamento e homem-natureza. É percebida a necessidade do ser humano de se re-significar no mundo, conhecendo a complexidade da natureza e pensando além da crise ecológica.

Foreign exchange rate entropy evolution during financial crises

Science.gov (United States)

Stosic, Darko; Stosic, Dusan; Ludermir, Teresa; de Oliveira, Wilson; Stosic, Tatijana

2016-05-01

This paper examines the effects of financial crises on foreign exchange (FX) markets, where entropy evolution is measured for different exchange rates, using the time-dependent block entropy method. Empirical results suggest that financial crises are associated with significant increase of exchange rate entropy, reflecting instability in FX market dynamics. In accordance with phenomenological expectations, it is found that FX markets with large liquidity and large trading volume are more inert - they recover quicker from a crisis than markets with small liquidity and small trading volume. Moreover, our numerical analysis shows that periods of economic uncertainty are preceded by periods of low entropy values, which may serve as a tool for anticipating the onset of financial crises.

As crises do capitalismo democrático

Directory of Open Access Journals (Sweden)

Wolfgang Streeck

2012-03-01

Full Text Available O autor discute as sucessivas crises econômicas ocorridas nos países capitalistas desde os anos 1970, interpretando-as como produto de tensões e contradições endêmicas entre mercados capitalistas e políticas democráticas.The article retraces the successive economic crises in the capitalist countries since the 1970's, reading them as the result of tensions and contradictions between capitalist markets and democratic politics.

Crise do trabalho hoje: desenvolvimento tecnológico, instabilidade do emprego e crise do capitalismo

Directory of Open Access Journals (Sweden)

Maurilio Lima Botelho

2016-06-01

Full Text Available O artigo procura retomar o tema da crise do trabalho discutindo três dimensões: o papel do desenvolvimento tecnológico na eliminação de postos de trabalho; a constante transformação nos processos produtivos que cria instabilidade no emprego e a improdutividade progressiva da força de trabalho mundial. Essas reflexões são a base para uma discussão mais ampla sobre a crise da sociedade do trabalho, isto é, a contradição estrutural que enfrentamos hoje de uma sociedade que tornou o trabalho como mecanismo básico de socialização, mas mobiliza todos os meios para eliminá-lo.

Linking Organizational Crises and Reactive Strategies via Dimensions Of Legitimacy

OpenAIRE

Heiko Breitsohl

2009-01-01

Research on organizational crises has typically focused on case studies or measures for crisis prevention, while the social dimension of crises has remained largely unexplored. In some rare exceptions, differences in the efficacy of reactive strategies depending on the type of crisis have been reported. However, the mechanisms behind these differences remain unclear. This paper aims to fill this gap by arguing that organizational crises and effective reactions are linked by different dimensio...

Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study

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Adel Gabriel

2010-10-01

Full Text Available Adel GabrielDepartments of Psychiatry and Community Health Sciences, University of Calgary, Alberta, CanadaBackground: There is a great need in the treatment of schizophrenia for a drug, or drug ­combinations, to improve clinical response with fewer serious side effects. The objective of this study was to explore the therapeutic effects and tolerability of the anticonvulsant gabapentin as an adjunctive in the treatment of patients with partially responsive schizophrenia.Methods: Ten consenting patients with a confirmed Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision diagnosis of schizophrenia were identified. All patients failed at least one 12-week treatment trial with risperidone or olanzapine. Gabapentin was added to ongoing antipsychotic treatment with olanzapine or risperidone for eight weeks. The primary outcome measure was the Positive and Negative Syndrome Scale (PANSS. Other scales included the Calgary Depression Scale (CDSS and the Abnormal Involuntary Movement Scale (AIMS. Repeated-measures multivariate analysis of variance was utilized to examine changes in outcome measures over time with adjunctive treatment with gabapentin.Results: There was a significant drop in the PANSS and CDSS scores at endpoint (week 8. There were no significant differences between the two treatment groups with regard to changes in all outcome measures or in AIMS score. The adjunctive treatments were well tolerated and side effects were transient.Conclusion: Gabapentin could be used successfully as an adjunct to novel antipsychotics in partially responsive schizophrenia. However, large controlled studies are needed to examine the effectiveness of gabapentin in psychotic disorders.Keywords: schizophrenia, refractory, adjunctive treatment, gabapentin, risperidone, olanzapine

How do banking crises affect aggregate consumption? Evidence from international crisis episodes

OpenAIRE

Gerlach-Kristen, Petra; O'Connell, Brian; O'Toole, Conor

2013-01-01

This paper considers the effect of systemic financial crises on aggregate consumption. Using a sample of 23 countries over 32 years, we find that consumption growth seems lower during banking crises, crises following credit booms and crises following house price booms. Moreover, the response to income growth seems to change, which may be due to credit constraints. In the long run, consumption appears to be linked to income, housing and other financial wealth.

An open-label extension study of the safety and efficacy of risperidone in children and adolescents with autistic disorder.

Science.gov (United States)

Kent, Justine M; Hough, David; Singh, Jaskaran; Karcher, Keith; Pandina, Gahan

2013-12-01

The purpose of this study was to evaluate the long-term safety and efficacy of risperidone in treating irritability and related behaviors in children and adolescents with autistic disorders. In this 6 month (26 week) open-label extension (OLE) study, patients (5-17 years of age, who completed the previous fixed-dose, 6 week, double-blind [DB] phase) were flexibly dosed with risperidone based on body weight. The maximum allowed dose was 1.25 mg/day for those weighing 20 to autistic, psychiatric, and behavioral disorders. Patients experienced some additional improvement in irritability and related behaviors. This phase-4 study is registered at ClinicalTrials.gov (NCT00576732).

Is Monetary Policy Effective During Financial Crises?

OpenAIRE

Frederic S. Mishkin

2009-01-01

This short paper argues that the view that monetary policy is ineffective during financial crises is not only wrong, but may promote policy inaction in the face of a severe contractionary shock. To the contrary, monetary policy is more potent during financial crises because aggressive monetary policy easing can make adverse feedback loops less likely. The fact that monetary policy is more potent than during normal times provides a rationale for a risk-management approach to counter the contra...

The de-escalation of nuclear crises

International Nuclear Information System (INIS)

Nation, J.E.

1992-01-01

Whether and by what means nations can successfully de-escalate nuclear crises - and avoid the disastrous effects of nuclear war - will remain two of the most critical challenges facing humankind. Whatever the future of superpower relations, the United States, the Soviet Union, and other nations will undoubtedly continue to possess and to threaten the use of nuclear weapons. Moreover, the number of nations with nuclear weapons seems likely to increase. This examines how nations in crises might successfully move back from the brink of nuclear war - and how confidence-building measures might help and hinder the de-escalatory process

International experiences with power supply crises

International Nuclear Information System (INIS)

2002-01-01

Many so-called deregulated power markets experience a hardened energy and power balance and some have had supply crises. This report discusses the crises, their impacts and their causes as well as the measures taken by the authorities to solve the crises. It also considers the similarities or dissimilarities with respect to the situation in Norway the winter 2002/2003. Like Norway, many of the countries have a considerable share of hydroelectric power. It is found, however, that the dependence on water of its own is not the reason for the crises, but that the inflow conditions give the market greater challenges. Furthermore, the Norwegian market has greater flexibility in the consumption, greater import capacity, better price security possibilities and less problems with market power than most of the countries here considered. Various factors influence a country's power consumption and production capacity. Economic growth and the availability of inexpensive power contribute to accelerate the consumption, while predictable external conditions and sufficient expected investment earnings are necessary to achieve an increase of the capacity - both through new investments and attendance to existing capacity. In a smooth power market there must be a certain correspondence between consumption and installed capacity, and the capacity must be such that it can cover the continuous demand for power and at the same time be flexible enough to deliver power at peak loads. This is also true of the transmission capacity. In addition, some extra capacity must be available for unexpected events. The basic problem is, in any power market, that the consumption may rise fast, while the investments in new capacity typically occurs in leaps, with long and costly construction phases. Many countries have lately experienced a hardening of the balance between consumption and capacity and so have been vulnerable to unexpected increases in consumption or resource failure. This was also the

Managing Product-Harm Crises

NARCIS (Netherlands)

H.J. van Heerde (Harald); K. Helsen; M.G. Dekimpe (Marnik)

2005-01-01

textabstractProduct-harm crises are among a firm’s worst nightmares. Since marketing investments may be instrumental to convince consumers to purchase the firm's products again, it is important to provide an adequate measurement of the effectiveness of these investments, especially after the crisis.

Assessment of strategies for switching patients from olanzapine to risperidone: A randomized, open-label, rater-blinded study

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Berry Sally A

2008-06-01

Full Text Available Abstract Background In clinical practice, physicians often need to change the antipsychotic medications they give to patients because of an inadequate response or the presence of unacceptable or unsafe side effects. However, there is a lack of consensus in the field as to the optimal switching strategy for antipsychotics, especially with regards to the speed at which the dose of the previous antipsychotic should be reduced. This paper assesses the short-term results of strategies for the discontinuation of olanzapine when initiating risperidone. Methods In a 6-week, randomized, open-label, rater-blinded study, patients with schizophrenia or schizoaffective disorder, on a stable drug dose for more than 30 days at entry, who were intolerant of or exhibiting a suboptimal symptom response to more than 30 days of olanzapine treatment, were randomly assigned to the following switch strategies (common risperidone initiation scheme; varying olanzapine discontinuation: (i abrupt strategy, where olanzapine was discontinued at risperidone initiation; (ii gradual 1 strategy, where olanzapine was given at 50% entry dose for 1 week after risperidone initiation and then discontinued; or (iii gradual 2 strategy, where olanzapine was given at 100% entry dose for 1 week, then at 50% in the second week, and then discontinued. Results The study enrolled 123 patients on stable doses of olanzapine. Their mean age was 40.3 years and mean (± standard deviation (SD baseline Positive and Negative Syndrome Scale (PANSS total score of 75.6 ± 11.5. All-cause treatment discontinuation was lowest (12% in the group with the slowest olanzapine dose reduction (gradual 2 and occurred at half the discontinuation rate in the other two groups (25% in abrupt and 28% in gradual 1. The relative risk of early discontinuation was 0.77 (confidence interval 0.61–0.99 for the slowest dose reduction compared with the other two strategies. After the medication was changed, improvements at

How does capital affect bank performance during financial crises?

NARCIS (Netherlands)

Berger, A.N.; Bouwman, C.H.S.

2013-01-01

This paper empirically examines how capital affects a bank’s performance (survival and market share) and how this effect varies across banking crises, market crises, and normal times that occurred in the US over the past quarter century. We have two main results. First, capital helps small banks to

Effects of Environmental Manipulations and Treatment with Bupropion and Risperidone on Choice between Methamphetamine and Food in Rhesus Monkeys.

Science.gov (United States)

Banks, Matthew L; Blough, Bruce E

2015-08-01

Preclinical and human laboratory choice procedures have been invaluable in improving our knowledge of the neurobiological mechanisms of drug reinforcement and in the drug development process for candidate medications to treat drug addiction. However, little is known about the neuropharmacological mechanisms of methamphetamine vs food choice. The aims of this study were to develop a methamphetamine vs food choice procedure and determine treatment effects with two clinically relevant compounds: the monoamine uptake inhibitor bupropion and the dopamine antagonist risperidone. Rhesus monkeys (n=6) responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and intravenous methamphetamine injections (0-0.32 mg/kg/injection, FR10 schedule) during 7-day bupropion (0.32-1.8 mg/kg/h) and risperidone (0.001-0.0056 mg/kg/h) treatment periods. For comparison, effects of removing food pellets or methamphetamine injections and FR response requirement manipulations were also examined. Under saline treatment conditions, food was preferred over no methamphetamine or small unit methamphetamine doses (0.01-0.032 mg/kg/injection). Larger methamphetamine doses resulted in greater methamphetamine preference and 0.32 mg/kg/injection methamphetamine maintained near exclusive preference. Removing food availability increased methamphetamine choice, whereas removing methamphetamine availability decreased methamphetamine choice. Methamphetamine choice was not significantly altered when the FR response requirements for food and drug were the same (FR100:FR100 or FR10:FR10). Risperidone treatment increased methamphetamine choice, whereas bupropion treatment did not alter methamphetamine choice up to doses that decreased rates of operant behavior. Overall, these negative results with bupropion and risperidone are concordant with previous human laboratory and clinical trials and support the potential validity of this preclinical methamphetamine vs food

Indicators of financial crises do work! : an early-warning system for six Asian countries

NARCIS (Netherlands)

Lestano, [No Value; Jacobs, Jan; Kuper, Gerard H.

2003-01-01

Indicators of financial crisis generally do not have a good track record. This paper presents an early warning system for six countries in Asia, in which indicators do work.We distinguish three types of financial crises, currency crises, banking crises and debt crises, and extract four groups of

Risperidone Versus Methylphenidate in Treatment of Preschool Children With Attention-Deficit Hyperactivity Disorder.

Science.gov (United States)

Arabgol, Fariba; Panaghi, Leily; Nikzad, Vahid

2015-02-01

Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric diagnosis among preschool children. The aim of this study was to examine the Risperidone treatment compared to Methylphenidate (MPH) in preschool children with ADHD. Thirty three outpatient preschool children, aged 3-6 years, diagnosed with ADHD (The diagnosis of ADHD was established by two child and adolescent psychiatrists according to the DSM-IV-TR criteria), participated in a 6-week, double-blind clinical trial with risperidone (0.5-1.5 mg/d) and methylphenidate (5-20 mg/d), in two divided doses. Treatment outcomes were assessed using the Parent ADHD Rating Scale and Conners Rating Scale. Patients were assessed by a child psychiatrist at baseline, 2, 4 and 6 weeks after the medication started. Side effects were also rated by side effects questionnaire. There were no significant differences between the two protocols on the Parent ADHD Rating Scale scores (P > 0.05) and Parent Conners Rating Scale scores (P > 0.05). Both groups showed a significant improvement in ADHD symptoms over the 6 weeks of treatment for parent ADHD Rating Scale (P benefits and adverse effects in long term use and comorbid conditions.

Comparative study of clozapine versus risperidone in treatment-naive, first-episode schizophrenia: A pilot study

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Sukhtej Sahni

2016-01-01

Interpretation & conclusions: The findings of this preliminary study showed clozapine as a better choice than risperidone in terms of efficacy, tolerability and better quality of life in treatment-naive, first-episode schizophrenia. However, further studies need to be done on a larger group of patients to confirm the findings.

Avaliando o efeito contágio entre economias durante crises financeiras

Directory of Open Access Journals (Sweden)

Fernanda Finotti Cordeiro Perobelli

2013-09-01

Full Text Available O objetivo deste trabalho, a partir das metodologias sugeridas por Forbes e Rigobon (2002 e Corsetti, Pericoli e Sbracia (2005, é verificar indícios de efeito contágio entre quinze economias em oito episódios de crises financeiras. Conclui-se que o modelo de Corsetti, Pericoli e Sbracia (2005, como esperado, apresentou-se mais eficiente em encontrar indícios de efeito contágio, uma vez que abrange variações nas componentes dos retornos não consideradas pelo modelo de Forbes e Rigobon (2002. Os resultados, corroborados por testes de robustez, indicam a crise asiática de 1997 como a mais contagiosa, seguida pelo ataque terrorista de 11 de setembro de 2001, crise brasileira de 1999, bolha da internet de 2000 e crise do Subprime. Os outros episódios não apresentaram indícios de contágio, o que indica choques restritos ao país de origem da crise.

Comparison between risperidone, an atypical antipsychotic agent and haloperidol, a conventional agent used to treat schizophrenia

International Nuclear Information System (INIS)

Rehman, A.; Jawed, M.; Maheshwari, M.P.

2012-01-01

An observational and comparative study was conducted to compare the functional outcome between the patients treated with conventional antipsychotic agent haloperidol and typical antipsychotic agent, Risperidone (Risperidal). A total of 32 patients were included in the study with established schizophrenia according to (DSM iv). The data was processed on SSPE 10th version. The primary outcome measure was the improvement of negative symptoms of schizophrenia and secondary outcome measure was to observe the superiority of the atypical drug Risperid one over conventional agent haloperidol regarding side effects. Patients were assessed at baseline, 2nd and 8th week, using four tools of assessment. For treatment group receiving haloperidol mean was 47.2+-11.50 at 8th week and for Risperidone treatment group mean was 43+-14.68. The P values for all the parameters in the Clozapine group were significant as compared to haloperidol. (author)

Worsening of myasthenia gravis after administration of injectable long-acting risperidone for treatment of schizophrenia; first case report and a call for caution.

Science.gov (United States)

Al-Hashel, Jasem Y; Ismail, Ismail Ibrahim; John, John K; Ibrahim, Mohammed; Ali, Mahmoud

2016-01-01

Myasthenia gravis is an autoimmune disease characterized by muscle weakness due to autoantibodies affecting the neuromuscular junction. Co-occurrence of myasthenia gravis and schizophrenia is very rare and raises a challenge in management of both diseases. Antipsychotic drugs exhibit anticholinergic side effects and have the potentials of worsening myasthenia. Long-acting risperidone is an injectable atypical antipsychotic drug that has not been previously reported to worsen myasthenia gravis in literature. We report the first case report of worsening of myasthenia after receiving long-acting risperidone injection for schizophrenia in a 29-year-old female with both diseases. She started to have worsening 2 weeks following the first injection and her symptoms persisted despite receiving plasma exchange. This could be explained by the pharmacokinetics of the drug. We recommend that long-acting risperidone should be used with caution in patients with myasthenia gravis, and clinicians must be aware of the potential risks of this therapy. Copyright © 2016 Elsevier B.V. All rights reserved.

Risperidone Added to Psychostimulant in Children with Severe Aggression and Attention-Deficit/Hyperactivity Disorder: Lack of Effect on Attention and Short-Term Memory.

Science.gov (United States)

Farmer, Cristan A; Epstein, Jeffery N; Findling, Robert L; Gadow, Kenneth D; Arnold, L Eugene; Kipp, Heidi; Kolko, David J; Butter, Eric; Schneider, Jayne; Bukstein, Oscar G; McNamara, Nora K; Molina, Brooke S G; Aman, Michael G

2017-03-01

Professionals have periodically expressed concern that atypical antipsychotics may cause cognitive blunting in treated patients. In this study, we report data from a double-blind, randomized, controlled study of stimulant plus placebo versus combined stimulant and risperidone to evaluate the effects of the atypical antipsychotic on attention and short-term memory. A total of 165 (n = 83 combined treatment; n = 82 stimulant plus placebo) children with attention-deficit/hyperactivity disorder and severe physical aggression, aged 6-12 years, were evaluated with Conners' Continuous Performance Test (CPT-II) and the Wechsler Intelligence Scale for Children-III (WISC) Digit Span subscale at baseline, after 3 weeks of stimulant-only treatment, and after six additional weeks of randomized treatment (stimulant+placebo vs. stimulant+risperidone). At 3 weeks, improvement on CPT-II performance (Commissions and Reaction Time Standard Error; p memory performance (p attention and short-term memory associated with short-term use of risperidone. NCT00796302.

Olanzapine has better efficacy compared to risperidone for treatment of negative symptoms in schizophrenia

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P N Suresh Kumar

2016-01-01

Conclusions: Both treatments were well-tolerated and efficacious. Greater reductions in severity of the illness and negative symptoms were seen with olanzapine consistently through 1 year. The frequency and severity of extrapyramidal symptoms were negligible and similar in the two treatment groups. Weight gain, hyperlipidemia, and hyperglycemia were comparable in both groups. Risperidone produced significant hyperprolactinemia.

Frequency of sexual dysfunction and other reproductive side-effects in patients with schizophrenia treated with risperidone, olanzapine, quetiapine, or haloperidol: the results of the EIRE study.

Science.gov (United States)

Bobes, J; Garc A-Portilla, M P; Rejas, J; Hern Ndez, G; Garcia-Garcia, M; Rico-Villademoros, F; Porras, A

2003-01-01

Atypical antipsychotics seem to differ mainly in their tolerability profile. The aim of this cross-sectional study, the Estudio de Investigaci n de Resultados en Esquizofrenia (Outcomes Research Study in Schizophrenia; EIRE study), was to assess in a clinical setting the frequency of several side-effects related to haloperidol, risperidone, olanzapine, and quetiapine. This article addresses sexual dysfunction and other reproductive side-effects (gynecomastia, menorrhage, amenorrhea, and galactorrhea). We recruited outpatients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) criteria and who had received a single antipsychotic (risperidone, olanzapine, quetiapine, or haloperidol) for at least 4 weeks. During a single visit, we collected data, including demographic and clinical characteristics, current antipsychotic and concomitant treatment, and adverse effects listed in a modified version of the UKU Scale. We used a Chi-squared test to determine pairs comparisons of the frequency of adverse reactions between treatments. To estimate risk of a given adverse reaction with a given treatment, we used a logistic regression method. We assessed 636 evaluable patients out of 669 recruited. Frequency of sexual dysfunction was high with haloperidol (38.1%) and also with olanzapine (35.3%), quetiapine (18.2%), and risperidone (43.2%). We found the frequency of other reproductive side-effects to be relatively low with all four drugs: haloperidol (6.9%), olanzapine (6.4%), quetiapine (2.7%), and risperidone (11.7%). Sexual dysfunction appeared to be dose-related with haloperidol, risperidone, and olanzapine. Risperidone and olanzapine showed a higher risk of sexual dysfunction and other reproductive sideeffects than haloperidol. Quetiapine showed a lower risk of sexual dysfunction during short-term treatment ( 12 weeks) are lacking. Our results suggest that none of the atypical

A Naturalistic Comparison of Methylphenidate and Risperidone Monotherapy in Drug-Naive Youth With Attention-Deficit/Hyperactivity Disorder Comorbid With Oppositional Defiant Disorder and Aggression.

Science.gov (United States)

Masi, Gabriele; Manfredi, Azzurra; Nieri, Giulia; Muratori, Pietro; Pfanner, Chiara; Milone, Annarita

2017-10-01

Attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) are frequently co-occurring in youth, but data about the pharmacological management of this comorbidity are scarce, especially when impulsive aggression is prominent. Although stimulants are the first-line medication for ADHD, second-generation antipsychotics, namely, risperidone, are frequently used. We aimed to assess effectiveness and safety of monotherapy with the stimulant methylphenidate (MPH) and risperidone in a consecutive sample of 40 drug-naive male youths diagnosed as having ADHD-combined presentation, comorbid with ODD and aggression, without psychiatric comorbidities, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and a structured clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version). Twenty males treated with MPH (mean age, 8.95 ± 1.67 years) and 20 males treated with risperidone (mean age, 9.35 ± 2.72 years), followed up to 6 months, were assessed according to efficacy measures (Child Behavior Checklist [CBCL], Clinical Global Impression-Severity [CGI-S] and Improvement [CGI-I], Children Global Assessment Scale), and safety measures. At the end of the follow-up, both medications were similarly effective based on CBCL subscales of aggression and rule-breaking behaviors, on Diagnostic and Statistical Manual of Mental Disorders-oriented oppositional defiant problems and conduct problems, and on CGI-S, CGI-I, and Children Global Assessment Scale, but only MPH was effective on CBCL attention problems and attention-deficit/hyperactivity problems. Risperidone was associated with weight gain and elevated prolactin levels. Although the nonrandomized, nonblind design limits the conclusions of our exploratory study, our findings suggest that when ADHD is comorbid with ODD and aggression MPH and risperidone are both effective on aggressive behavior, but

Building European Union capacity to manage transboundary crises : Network or lead-agency model?

NARCIS (Netherlands)

Boin, Arjen; Busuioc, Madalina; Groenleer, Martijn

2014-01-01

In recent years, the European continent has witnessed a substantial number of "transboundary crises" - crises that cross geographical borders and affect multiple policy domains. Nation states find it hard to deal with such crises by themselves. International cooperation, thus, becomes increasingly

Macroeconomic narratives in a world of crises

DEFF Research Database (Denmark)

Urhammer, Emil; Røpke, Inge

2013-01-01

Since the financial crisis in 2008, a series of publications on macroeconomic responses to the compound crises of the economy and the environment have emerged. Under labels such as green new deal, green growth and the great transition, attempts at offering coherent responses to the crises have been...... discourse theory and narrative analysis and investigates discourses by studying the narratives they produce. The study thus contributes to the long line of analyses on discourses on sustainable economy: empirically, by investigating and analysing a number of macroeconomic proposals for solving the system...

Validation of an analytical method applicable to study of 1 mg/mL oral Risperidone solution stability

International Nuclear Information System (INIS)

Abreu Alvarez, Maikel; Garcia Penna, Caridad Margarita; Martinez Miranda, Lissette

2010-01-01

A validated analytical method by high-performance liquid chromatography (HPLC) was applicable to study of 1 mg/mL Risperidone oral solution stability. The above method was linear, accurate, specific and exact. A stability study of the 1 mg/mL Risperidone oral solution was developed determining its expiry date. The shelf life study was conducted for 24 months at room temperature; whereas the accelerated stability study was conducted with product under influence of humidity and temperature; analysis was made during 3 months. Formula fulfilled the quality specifications described in Pharmacopeia. The results of stability according to shelf life after 24 months showed that the product maintains the parameters determining its quality during this time and in accelerated studies there was not significant degradation (p> 0.05) in the product. Under mentioned conditions expiry date was of 2 years

Networked Social Reproduction: Crises in the Integrated Circuit

Directory of Open Access Journals (Sweden)

Elise Danielle Thorburn

2016-07-01

Full Text Available This paper argues that the means of communication are sites for, and aspects of, social reproduction. In contemporary capitalism, motivated as it is by new, networked digital technologies, social reproduction is increasingly virtualised through the means of communication. Although recent political struggles have demonstrated how networked technologies can liberate social reproduction from the profit motive and from commodifying impulses, the tendency is to invoke and accelerate socially reproductive crises—crises in the capacity to reproduce ourselves both daily and intergenerationally. These crises have psychic and corporeal impacts, and intensify Tronti’s “social factory” thesis of capital’s technical composition. In order to develop modes and means of liberatory communication in the integrated circuit it is necessary to untangle and chart both the pathways and outcomes of the crises networked social reproduction invokes.

Crise alimentaire recente dans le troisieme arrondissement de ...

African Journals Online (AJOL)

L'objectif de cette recherche est d'étudier les répercussions de la récente crise alimentaire sur les ménages de même que les stratégies développées en réaction aux effets de la crise. La démarche méthodologique adoptée dans le cadre de cette recherche est essentiellement basée sur la recherche documentaire et les ...

Dietary Status and Impact of Risperidone on Nutritional Balance in Children with Autism: A Pilot Study

Science.gov (United States)

Lindsay, Ronald L.; Arnold, L. Eugene; Aman, Michael G.; Vitiello, Benedetto; Posey, David J.; McDougle, Christopher J.; Scahill, Lawrence; Pachler, Maryellen; McCracken, James T.; Tierney, Elaine; Bozzolo, Dawn

2006-01-01

Background: Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain. Method: Using a quantitative Food Frequency Questionnaire (FFQ), we prospectively examined the nutritional intake of 20 children with autism participating in a randomised…

Efficacy of Risperidone Augmentation with Ondansetron in the Treatment of Negative and Depressive Symptoms in Schizophrenia: A Randomized Clinical Trial

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Roya Samadi

2017-01-01

Full Text Available Background: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia. Methods: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7, in 2012–2013 in Mashhad, Iran, 38 patients with treatment-resistant schizophrenia received risperidone either combined with a fixed dose (4–8 mg/d of ondansetron (n=18 or with a placebo (n=20 for 12 weeks. The patients were evaluated using the Positive and Negative Syndrome Scale (PANSS, Wechsler’s Adult Intelligence Scale-Revised (WAIS-R, and Hamilton’s Rating Scale for Depression (HRSD at baseline and 12 weeks later. Changes in the inventories were used to evaluate the efficacy of the treatment. The t test, Chi-square test, and SPSS (version 16 were used to analyze the data. The statistical significance was set at P<0.05. Results: Ondansetron plus risperidone was associated with a significantly larger improvement in the PANSS overall scale and subscales for negative symptoms and cognition than was risperidone plus placebo (P<0.001. The WAIS-R scale results indicated significant differences between the 2 groups before and after administrating the medicine and the placebo. The administration of ondansetron significantly improved visual memory based on the subtests of the WAIS (P<0.05. Ondansetron had no positive effects on depressive symptoms (effect size=0.13. Conclusion: This study confirmed that ondansetron, as an adjunct treatment, reduces negative symptoms in patients with schizophrenia and can be used as a potential adjunctive strategy particularly for negative symptoms and cognitive impairments. Trial Registration Number: IRCT201112125280N7

Effects of aripiprazole versus risperidone on brain activation during planning and social-emotional evaluation in schizophrenia: A single-blind randomized exploratory study.

Science.gov (United States)

Liemburg, Edith J; van Es, Frank; Knegtering, Henderikus; Aleman, André

2017-10-03

Impaired function of prefrontal brain networks may be the source of both negative symptoms and neurocognitive problems in psychotic disorders. Whereas most antipsychotics may decrease prefrontal activation, the partial dopamine D2-receptor agonist aripiprazole is hypothesized to improve prefrontal function. This study investigated whether patients with a psychotic disorder would show stronger activation of prefrontal areas and associated regions after treatment with aripiprazole compared to risperidone treatment. In this exploratory pharmacological neuroimaging study, 24 patients were randomly assigned to either aripiprazole or risperidone. At baseline and after nine weeks treatment they underwent an interview and MRI session. Here we report on brain activation (measured with arterial spin labeling) during performance of two tasks, the Tower of London and the Wall of Faces. Aripiprazole treatment decreased activation of the middle frontal, superior frontal and occipital gyrus (ToL) and medial temporal and inferior frontal gyrus, putamen and cuneus (WoF), while activation increased after risperidone. Activation increased in the ventral anterior cingulate and posterior insula (ToL), and superior frontal, superior temporal and precentral gyrus (WoF) after aripiprazole treatment and decreased after risperidone. Both treatment groups had increased ventral insula activation (ToL) and middle temporal gyrus (WoF), and decreased occipital cortex, precuneus and caudate head activation (ToL) activation. In conclusion, patients treated with aripiprazole may need less frontal resources for planning performance and may show increased frontotemporal and frontostriatal reactivity to emotional stimuli. More research is needed to corroborate and extend these preliminary findings. Copyright © 2017 Elsevier Inc. All rights reserved.

Very Low-Dose Risperidone in First-Episode Psychosis: A Safe and Effective Way to Initiate Treatment

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Patrick D. McGorry

2011-01-01

Full Text Available Patients experiencing a first psychotic episode have high rates of extrapyramidal symptoms (EPSs when treated with the doses of neuroleptics used in multiepisode or chronic schizophrenia. There is some evidence that lower doses may be equally, if not more, effective but less toxic in this population. Here, we report the results of a biphasic open label trial designed to assess the efficacy, safety, and tolerability of low-dose (2–4 mg/day risperidone treatment in a group of 96 first-episode nonaffective psychosis patients. At the end of the trial, 62% of patients met the response criteria although approximately 80% had achieved a response at some time during the study. Reports of EPS remained low, and there were no dystonic reactions. We conclude that even at a dose of 2 mg/day, risperidone was highly effective in reducing acute symptomatology in a real world sample of young first-episode psychosis patients.

Risperidone Versus Methylphenidate in Treatment of Preschool Children With Attention-Deficit Hyperactivity Disorder

OpenAIRE

Arabgol, Fariba; Panaghi, Leily; Nikzad, Vahid

2015-01-01

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric diagnosis among preschool children. Objectives: The aim of this study was to examine the Risperidone treatment compared to Methylphenidate (MPH) in preschool children with ADHD. Patients and Methods: Thirty three outpatient preschool children, aged 3-6 years, diagnosed with ADHD (The diagnosis of ADHD was established by two child and adolescent psychiatrists according to the DSM-IV-TR criteria), participated i...

Crises parciais motoras induzidas por movimentos em pacientes diabéticos

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Glória M. A. S. Tedrus

1991-12-01

Full Text Available Levando em conta o número restrito de casos em âmbito internacional e a ausência de publicações na literatura nacional, os autores apresentam três casos de crises motoras focais induzidas por movimentos em pacientes diabéticos com mais de 50 anos de idade. As crises eram numerosas, sendo também desencadeadas ao serem assumidas determinadas posturas. Em dois casos havia hiperglicemia não cetótica. Todos os pacientes apresentavam hemiparesia e, em dois, tal déficit desapareceu após o cotnrole das crises. No outro paciente a hemiparesia era decorrente de acidente vascular cerebral isquêmico instalado 6 meses antes. Síndrome parietal transitória foi observada nos três pacientes. O EEG crítico mostrou, em dois pacientes, descargas na região parieto-occipital e, em um, na região temporal média contralateral. As crises foram resistentes aos anticonvulsivantes, só havendo controle com o tratamento dos distúrbios metabólicos. São discutidos aspectos clínico-eletren-cefalográficos e etiopatogênicos. A pesquisa do caráter reflexo das crises e a dosagem da glicemia devem ser feitas em todos os pacientes idosos com crises motoras focais, face às implicações de ordem terapêutica e prognóstica.

Rationalised panics : The consequences of strategic uncertainty during financial crises

NARCIS (Netherlands)

Daniëls, T.

2009-01-01

This dissertation is about currency and related financial crises such as the contagious Southeast Asian crisis of 1997 or Argentina's collapse and default in 2001. It argues that key to understanding these crises is the doubt that they inflict on market participants about the intentions and actions

Preparation and in-vitro characterization of Risperidone-cyclodextrin inclusion complexes as a potential injectable product

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D Shukla

2009-12-01

Full Text Available "n  "n Background and the purpose of the study: This investigation deals with risperidone cyclodextrin (CD complexation for parenteral administration to improve its aqueous solubility which would be beneficial over immediate and sustained release formulations available in market especially for agitated and non-cooperative psychotic patients. "nMethods: The phase solubility study of the drug with β-CD, hydroxypropyl (HP-β-CD and γ-CD was conducted and CDs with higher stability constants were selected for complexation. The complexes of Risperidone with β-CD and HP-β-CD were prepared by precipitation and vacuum drying methods, respectively. Fourier transform-infrared, X-ray diffraction and differential scanning calorimetry techniques were used for characterization of complexes. Drug precipitation study of complex's solution in water for injection and 100 ml of 0.1 M pH 7.4 phosphate buffer saline and stability study in accelerated condition were also carried out. "nResults: The stability constants of the CD were in the following order: β-CD (341.953±11.87 M-1 > HP-β-CD (170.817± 5.93 M-1 > γ-CD (93.716 ± 3.25 M-1. CDs with high stability constants were selected to prepare the drug CD complex. The complexation efficiencies of β-CD and HP-β-CD were 95.23 ± 2.27% and 97.59 ±1.97%, respectively. Both types of CDs exhibited complexation at 1:2 molar stoichiometric ratio. The drug precipitation study indicated complete solubility (100% drug dissolution without a trace of precipitate within 5 mins. The complexes were found to be stable for a period of 3 months under accelerated stability conditions. Major conclusion:Stable complexes of risperidone were successfully formulated using both β-CD and HP-β-CD by simple and highly efficient methods of complexation for parenteral administration.

Dried Blood Spots Combined With Ultra-High-Performance Liquid Chromatography-Mass Spectrometry for the Quantification of the Antipsychotics Risperidone, Aripiprazole, Pipamperone, and Their Major Metabolites.

Science.gov (United States)

Tron, Camille; Kloosterboer, Sanne M; van der Nagel, Bart C H; Wijma, Rixt A; Dierckx, Bram; Dieleman, Gwen C; van Gelder, Teun; Koch, Birgit C P

2017-08-01

Risperidone, aripiprazole, and pipamperone are antipsychotic drugs frequently prescribed for the treatment of comorbid behavioral problems in children with autism spectrum disorders. Therapeutic drug monitoring (TDM) could be useful to decrease side effects and to improve patient outcome. Dried blood spot (DBS) sample collection seems to be an attractive technique to develop TDM of these drugs in a pediatric population. The aim of this work was to develop and validate a DBS assay suitable for TDM and home sampling. Risperidone, 9-OH risperidone, aripiprazole, dehydroaripiprazole, and pipamperone were extracted from DBS and analyzed by ultra-high-performance liquid chromatography-tandem mass spectrometry using a C18 reversed-phase column with a mobile phase consisting of ammonium acetate/formic acid in water or methanol. The suitability of DBS for TDM was assessed by studying the influence of specific parameters: extraction solution, EDTA carryover, hematocrit, punching location, spot volume, and hemolysis. The assay was validated with respect to conventional guidelines for bioanalytical methods. The method was linear, specific without any critical matrix effect, and with a mean recovery around 90%. Accuracy and imprecision were within the acceptance criteria in samples with hematocrit values from 30% to 45%. EDTA or hemolysis did not skew the results, and no punching carryover was observed. No significant influence of the spot volume or the punch location was observed. The antipsychotics were all stable in DBS stored 10 days at room temperature and 1 month at 4 or -80°C. The method was successfully applied to quantify the 3 antipsychotics and their metabolites in patient samples. A UHPLC-MS/MS method has been successfully validated for the simultaneous quantification of risperidone, 9-OH risperidone, aripiprazole, dehydroaripiprazole, and pipamperone in DBS. The assay provided good analytical performances for TDM and clinical research applications.

Crises gêmeas nos mercados emergentes: América Latina x Leste Asiático

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Tito Belchior Silva Moreira

2009-06-01

Full Text Available This article uses a crisis index based on an average of the variations in currency and financial crises indicators, referred to as “twin crises ”, adjusting them to the same volatility. Thus, the objective is to measure the degree of vulnerability to twin crises within a group of 19 countries in the context of the East Asian crisis. Based on the crisis index regarding data from 1996, the most vulnerable countries of the twin crises can be ordered and identified a year before the onset of the crises. East Asian countries, in contrast with Latin American countries, were identified as the most vulnerable to twin crises.

Crises gêmeas nos mercados emergentes: América Latina x Leste Asiático

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Tito Belchior Silva Moreira

2004-01-01

Full Text Available This article uses a crisis index based on an average of the variations in currency and financial crises indicators, referred to as "twin crises", adjusting them to the same volatility. Thus, the objective is to measure the degree of vulnerability to twin crises within a group of 19 countries in the context of the East Asian crisis. Based on the crisis index regarding data from 1996, the most vulnerable countries of the twin crises can be ordered and identified a year before the onset of the crises. East Asian countries, in contrast with Latin American countries, were identified as the most vulnerable to twin crises.

Intervention in systemic banking crises

NARCIS (Netherlands)

Homar, T.

2016-01-01

Systemic banking crises often continue into recessions with large output losses. Governments and central banks intervene to preserve the key functions of the financial system and to mitigate the adverse impact of financial distress on economic growth. This thesis investigates how effective

A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder.

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Akhondzadeh, Shahin; Tajdar, Hamid; Mohammadi, Mohammad-Reza; Mohammadi, Mohammad; Nouroozinejad, Gholam-Hossein; Shabstari, Omid L; Ghelichnia, Hossein-Ali

2008-09-01

It has been reported that autism is a hypoglutamatergic disorder. Therefore, it was of interest to assess the efficacy of piracetam, a positive modulator of AMPA-sensitive glutamate receptors in autistic disorder. About 40 children between the ages three and 11 years (inclusive) with a DSM IV clinical diagnosis of autism and who were outpatients from a specialty clinic for children were recruited. The children presented with a chief complaint of severely disruptive symptoms related to autistic disorder. Patients were randomly allocated to piracetam + risperidone (Group A) or placebo + risperidone (Group B) for a 10-week, double-blind, placebo-controlled study. The dose of risperidone was titrated up to 2 mg/day for children between 10 and 40 kg and 3 mg/day for children weighting above 40 kg. The dose of piracetam was titrated up to 800 mg/day. Patients were assessed at baseline and after 2, 4, 6, 8 and 10 weeks of starting medication. The measure of the outcome was the Aberrant Behavior Checklist-Community (ABC-C) Rating Scale (total score). The ABC-C Rating Scale scores improved with piracetam. The difference between the two protocols was significant as indicated by the effect of group, the between subjects factor (F = 5.85, d.f. = 1, P = 0.02). The changes at the endpoint compared with baseline were: -11.90 +/- 3.79 (mean +/- SD) and -5.15 +/- 3.04 for group A and B respectively. A significant difference was observed on the change in scores in the ABC-C Rating Scale in week 10 compared with baseline in the two groups (t = 6.017, d.f. = 38, P treatment of autism.

Pregnancy exposure to olanzapine, quetiapine, risperidone, aripiprazole and risk of congenital malformations. A systematic review

DEFF Research Database (Denmark)

Ennis, Zandra Nymand; Damkier, Per

2015-01-01

/22 (5.1%) and 100/5 (5.0%), respectively. Relative risk estimates and 95% confidence intervals were 1.0 (0.7-1.4) (olanzapine), 1.0 (0.6-1.7) (quetiapine), 1.5 (0.9-2.2) (risperidone) and 1.4 (0.5-3.1) (aripiprazole). First-trimester exposure to olanzapine is not associated with an increased risk...

Organizational Crises and Reactions from a Legitimacy Perspective - Results from Two Multiple-case Studies

OpenAIRE

Heiko Breitsohl

2009-01-01

Organizational crises can be conceptualized as interactions between organizations and stake-holders around the breach and reestablishment of common norms and social codes, i.e. per-ceptions of legitimacy. This paper contributes to the understanding of organizational crises by exploring the roles of dimensions of legitimacy in organizational crises as well as the role of different reactions in the resolution of crises. Results of two qualitative multiple-case studies based on analyses of media...

A crise Baring e a crise do Encilhamento nos quadros da economia-mundo capitalista The Baring crisis and the Encilhamento crisis in the context of the capitalist world-economy

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Felipe Amin Filomeno

2010-04-01

Full Text Available O final do século XIX foi marcado, para Brasil e Argentina, por crescimento e instabilidade na economia. Neste período, ocorreram duas importantes crises econômicas, que ficaram conhecidas como crise Baring (na Argentina e crise do Encilhamento (no Brasil. Este artigo tem o objetivo de apresentar as conexões existentes entre essas duas crises e a conjuntura da economia-mundo capitalista das últimas décadas do século XIX, enfatizando o problema da dívida externa e da política econômica, e re-organizando algumas contribuições da historiografia econômica por meio da metodologia da "encompassing comparison" e da teoria dos ciclos mundiais de endividamento. O artigo mostra que ambas as crises estiveram condicionadas pela dinâmica da economia-mundo capitalista, especialmente pelos fluxos mundiais de capital, não sendo resultados exclusivos de políticas econômicas nacionais.The end of the 19th century was characterized by economic growth and instability in Brazil and Argentina. In this period, two important economic crises took place - the Baring Crisis (in Argentina and the Encilhamento Crisis (in Brazil. The aim of this paper is to present the connections between these two crises and the dynamics of the capitalist world-economy of the end of the 19th century, focusing on the problems of external debt and economic policy and re-organizing some contributions of economic historiography through the methodology of "encompassing comparison" and of the world debt cycles' theory. The paper concludes that both crises were influenced by the dynamics of the capitalist world-economy, especially by the international flows of capital, and that they were not exclusive results of national economic policies.

Managing transboundary crises: Identifying building blocks of an effective response system.

NARCIS (Netherlands)

Ansell, C; Boin, R.A.|info:eu-repo/dai/nl/161938876; Keller, A

2010-01-01

In recent years, crises have become increasingly transboundary in nature. This exploratory paper investigates whether and how the transboundary dimensions of crises such as pandemics, cyber attacks and prolonged critical infrastructure failure accentuate the challenges that public and private

Effects of Financial Crises on the Long Memory Volatility Dependency of Foreign Exchange Rates: the Asian Crisis vs. the Global Crisis

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Young Wook Han

2014-03-01

Full Text Available This paper examines the effects of financial crises on the long memory volatility dependency of daily exchange returns focusing on the Asian crisis in 97-98 and the Global crisis in 08-09. By using the daily KRW-USD and JPY-USD exchange rates which have different trading regions and volumes, this paper first applies both the parametric FIGARCH model and the semi-parametric Local Whittle method to estimate the long memory volatility dependency of the daily returns and the temporally aggregated returns of the two exchange rates. Then it compares the effects of the two financial crises on the long memory volatility dependency of the daily returns. The estimation results reflect that the long memory volatility dependency of the KRW-USD is generally greater than that of the JPY-USD returns and the long memory dependency of the two returns appears to be invariant to temporal aggregation. And, the two financial crises appear to affect the volatility dynamics of all the returns by inducing greater long memory dependency in the volatility process of the exchange returns, but the degree of the effects of the two crises seems to be different on the exchange rates.

Divergent long-term consequences of chronic treatment with haloperidol, risperidone, and bromocriptine on traumatic brain injury-induced cognitive deficits.

Science.gov (United States)

Phelps, Thomas I; Bondi, Corina O; Ahmed, Rashid H; Olugbade, Yewande T; Kline, Anthony E

2015-04-15

Antipsychotic drugs (APDs) are provided in the clinic to manage traumatic brain injury (TBI)-induced agitation and aggression. Experimental TBI studies consistently show that daily administration of the APDs, haloperidol (HAL) and risperidone (RISP), hinder recovery. However, it is unknown how long the adverse effects remain after cessation of treatment. To elucidate this clinically relevant issue, anesthetized male rats were randomly assigned to four TBI (controlled cortical impact) and four sham groups administered HAL (0.5 mg/kg), RISP (0.45 mg/kg), bromocriptine (BRO; 5.0 mg/kg, included as a control for D2 receptor action), or vehicle (VEH; 1 mL/kg) 24 h after surgery and once-daily for 19 days. Motor and cognitive recovery was assessed on days 1-5 and 14-19, respectively, and again at 1 and 3 months after drug withdrawal. No overall group differences were observed for motor function among the TBI groups, although the HAL group showed a greater beam-walk deficit on day 5 versus the VEH and BRO groups. Cognitive recovery was significantly impaired in the HAL and RISP groups during the treatment phase versus VEH and BRO. Further, BRO was superior to VEH (p=0.0042). At 1 month, both groups that received APDs continued to exhibit significant cognitive impairment versus VEH and BRO; at 3 months, only the HAL group was impaired. Moreover, the HAL, RISP, and VEH groups continued to be cognitively deficient versus BRO, which also reduced cortical damage. These data replicate previous reports that HAL and RISP impede cognitive recovery after TBI and expand the literature by revealing that the deleterious effects persist for 3 months after drug discontinuation. BRO conferred cognitive benefits when administered concomitantly with behavioral testing, thus replicating previous findings, and also after cessation demonstrating enduring efficacy.

String of defaults: Spanish financial crises through the years

OpenAIRE

Shachmurove, Tomer; Shachmurove, Yochanan

2011-01-01

Like many countries, Spain has gone through a series of financial crises, both before and after its industrialization. There are many underlying causes for these crises, as well as for the current Spanish downturn. It is worth noting that there are similarities between recessions throughout the history of Spain. The role of government spending, government regulation, credit institutions, budget deficits, the political climate, and international trade have been important determinants of the st...

The effects of systemic crises when investors can be crisis ignorant

NARCIS (Netherlands)

H.J.W.G. Kole (Erik); C.G. Koedijk (Kees); M.J.C.M. Verbeek (Marno)

2004-01-01

textabstractSystemic crises can largely affect asset allocations due to the rapid deterioration of the risk-return trade-off. We investigate the effects of systemic crises, interpreted as global simultaneous shocks to financial markets, by introducing an investor adopting a crisis ignorant or crisis

Towards a realtime Twitter analysis during crises for operational crisis management

NARCIS (Netherlands)

Terpstra, T.; Stronkman, R.J.P.; Vries, A. de; Paradies, G.L.

2012-01-01

Today's crises attract great attention on social media, from local and distant citizens as well as from news media. This study investigates the possibilities of real-time and automated analysis of Twitter messages during crises. The analysis was performed through application of an information

Ziprasidone versus olanzapine, risperidone or quetiapine in patients with chronic schizophrenia: a 12-week open-label, multicentre clinical trial

DEFF Research Database (Denmark)

Lublin, Henrik; Haug, Hans-Joachim; Koponen, Hannu

2009-01-01

The efficacy, safety and tolerability of ziprasidone versus the comparators olanzapine, risperidone or quetiapine were investigated in adult patients with chronic schizophrenia, schizoaffective and schizophreniform disorders, with lack of efficacy or intolerance to their previous antipsychotic tr...

Global effects of local food-production crises: a virtual water perspective.

Science.gov (United States)

Tamea, Stefania; Laio, Francesco; Ridolfi, Luca

2016-01-25

By importing food and agricultural goods, countries cope with the heterogeneous global water distribution and often rely on water resources available abroad. The virtual displacement of the water used to produce such goods (known as virtual water) connects together, in a global water system, all countries participating to the international trade network. Local food-production crises, having social, economic or environmental origin, propagate in this network, modifying the virtual water trade and perturbing local and global food availability, quantified in terms of virtual water. We analyze here the possible effects of local crises by developing a new propagation model, parsimonious but grounded on data-based and statistically-verified assumptions, whose effectiveness is proved on the Argentinean crisis in 2008-09. The model serves as the basis to propose indicators of crisis impact and country vulnerability to external food-production crises, which highlight that countries with largest water resources have the highest impact on the international trade, and that not only water-scarce but also wealthy and globalized countries are among the most vulnerable to external crises. The temporal analysis reveals that global average vulnerability has increased over time and that stronger effects of crises are now found in countries with low food (and water) availability.

Psychological Support for Families During Crises (as exemplified by families members of Ukrainian war veterans

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Yablonska Tetiana

2017-06-01

Full Text Available The goal of the article is to describe the theoretical and empirical research of characteristics of families under non-normative crises, having as an example the families of combatants participated in the anti-terrorist operation in Ukraine. The following family crises are discussed: normative crises, as period of transition from one stage of the family life cycle to another and non-normative crises caused by traumatic life events.

Comparison of risperidone and aripiprazole in the treatment of preschool children with disruptive behavior disorder and attention deficit-hyperactivity disorder: A randomized clinical trial

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Parvin Safavi

2016-01-01

Full Text Available Although pharmacotherapy with atypical antipsychotics is common in child psychiatry, there has been little research on this issue. To compare the efficacy and safety of risperidone and aripiprazole in the treatment of preschool children with disruptive behavior disorders comorbid with attention deficit-hyperactivity disorder (ADHD. Randomized clinical trial conducted in a university-affiliated child psychiatry clinic in southwest Iran. Forty 3-6-year-old children, diagnosed with oppositional defiant disorder comorbid with ADHD, were randomized to an 8-week trial of treatment with risperidone or aripiprazole (20 patients in each group. Assessment was performed by Conners′ rating scale-revised and clinical global impressions scale, before treatment, and at weeks 2, 4, and 8 of treatment. The data were analyzed by SPSS version 16. Mean scores between the two groups were compared by analysis of variance and independent and paired t-test. Mean scores of Conners rating scales were not different between two groups in any steps of evaluation. Both groups had significantly reduced scores in week 2 of treatment (P = 0.00, with no significant change in subsequent measurements. Rates of improvement, mean increase in weight (P = 0.894, and mean change in fasting blood sugar (P = 0.671 were not significantly different between two groups. Mean serum prolactin showed a significant increase in risperidone group (P = 0.00. Both risperidone and aripiprazole were equally effective in reducing symptoms of ADHD and oppositional defiant disorder, and relatively safe, but high rates of side effects suggest the cautious use of these drugs in children.

A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice.

Science.gov (United States)

Motyl, Katherine J; Beauchemin, Megan; Barlow, Deborah; Le, Phuong T; Nagano, Kenichi; Treyball, Annika; Contractor, Anisha; Baron, Roland; Rosen, Clifford J; Houseknecht, Karen L

2017-10-01

Atypical antipsychotic (AA) drugs, including risperidone (RIS), are used to treat schizophrenia, bipolar disorder, and autism, and are prescribed off-label for other mental health issues. AA drugs are associated with severe metabolic side effects of obesity and type 2 diabetes. Cross-sectional and longitudinal data also show that risperidone causes bone loss and increases fracture risk in both men and women. There are several potential mechanisms of bone loss from RIS. One is hypogonadism due to hyperprolactinemia from dopamine receptor antagonism. However, many patients have normal prolactin levels; moreover we demonstrated that bone loss from RIS in mice can be blocked by inhibition of β-adrenergic receptor activation with propranolol, suggesting the sympathetic nervous system (SNS) plays a pathological role. Further, when, we treated ovariectomized (OVX) and sham operated mice daily for 8weeks with RIS or vehicle we demonstrated that RIS causes significant trabecular bone loss in both sham operated and OVX mice. RIS directly suppressed osteoblast number in both sham and OVX mice, but increased osteoclast number and surface in OVX mice alone, potentially accounting for the augmented bone loss. Thus, hypogonadism alone cannot explain RIS induced bone loss. In the current study, we show that dopamine and RIS are present in the bone marrow compartment and that RIS can exert its effects directly on bone cells via dopamine receptors. Our findings of both direct and indirect effects of AA drugs on bone are relevant for current and future clinical and translational studies investigating the mechanism of skeletal changes from AA drugs. Copyright © 2017 Elsevier Inc. All rights reserved.

A case report of schizoaffective disorder with ritualistic behaviors and catatonic stupor: successful treatment by risperidone and modified electroconvulsive therapy.

Science.gov (United States)

Bai, Yuanhan; Yang, Xi; Zeng, Zhiqiang; Yang, Haichen

2018-03-13

Ritualistic behaviors are common in obsessive compulsive disorder (OCD), while catatonic stupor occasionally occurs in psychotic or mood disorders. Schizoaffective disorder is a specific mental disorder involving both psychotic and affective symptoms. The syndrome usually represents a specific diagnosis, as in the case of the 10th edition of the International Classification of Diseases (ICD-10) or the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). However, symptom-based diagnosis can result in misdiagnosis and hinder effective treatment. Few cases of ritualistic behaviors and catatonic stupor associated with schizoaffective disorder have been reported. Risperidone and modified electroconvulsive therapy (MECT) were effective in our case. A 35-year-old man with schizoaffective disorder-depression was admitted to the hospital because of ritualistic behaviors, depression, and distrust. At the time of admission, prominent ritualistic behaviors and depression misled us to make the diagnosis of OCD. Sertraline add-on treatment exacerbated the psychotic symptoms, such as pressure of thoughts and delusion of control. In the presence of obvious psychotic symptoms and depression, schizoaffective disorder-depression was diagnosed according to ICD-10. Meanwhile, the patient unfortunately developed catatonic stupor and respiratory infection, which was identified by respiratory symptoms, blood tests, and a chest X-ray. To treat psychotic symptoms, catatonic stupor, and respiratory infection, risperidone, MECT, and ceftriaxone were administered. As a result, we successfully cured the patient with the abovementioned treatment strategies. Eventually, the patient was diagnosed with schizoaffective disorder-depression with ritualistic behaviors and catatonia. Risperidone and MECT therapies were dramatically effective. Making a differential diagnosis of mental disorders is a key step in treating disease. Sertraline was not recommended for treating

Risperidone long-acting injection: a review of its long term safety and efficacy

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Michael K Rainer

2008-08-01

Full Text Available Michael K RainerMemory-Clinic and Psychiatric Department, Donauspital, Vienna, AustriaAbstract: A long-acting form of the second-generation antipsychotic drug risperidone is now broadly available for the treatment of schizophrenia and closely related psychiatric conditions. It combines the advantage of previously available depot formulations for first-generation drugs with the favorable characteristics of the modern “atypical” antipsychotics, namely higher efficacy in the treatment of the negative symptoms of schizophrenia and reduced motor disturbances. Published clinical studies show an objective clinical efficacy (as per psychiatric symptom scores and relapse data that exceeds that of oral atypical antipsychotics when patients are switched to the long-acting injectable form, a low incidence of treatment-emergent extrapyramidal side effects, and very good acceptance by patients. Available data for maintenance treatment of bipolar disorder show equivalence with the oral form instead of superiority, but are still limited. As it seems likely that efficacy benefits are mostly due to the fact that the injectable form reduces the demand for patient compliance to one physician visit every 2 weeks instead of self-administration on a daily or twice-daily basis, additional potential could exist in other psychiatric disorders where atypical antipsychotic drugs are of benefit but where patient adherence to treatment schedules is typically low.Keywords: risperidone, schizophrenia, psychotic disorders, patient compliance; delayed-action preparations, injections, intramuscular

Adolf Hitler had post-encephalitic Parkinsonism.

Science.gov (United States)

Lieberman, A

1996-04-01

Adolf Hitler had Parkinson symptoms in 1934, at age 45 years. He may have had transient symptoms in 1923, at age 34 years. Young-onset parkinsonism, during the 1920s, favored a diagnosis of post-encephalitic rather than idiopathic parkinsonism. Hitler had oculogyric crises, phenomena only associated with post-encephalitic parkinsonism. In addition, he had dystonic facial spasms, palilalia and a sleep disorder, phenomena more likely to be associated with post-encephalitic than idiopathic parkinsonism. In November 1918, at age 29 years, Hitler may have had von Economo's encephalitis, while he was a patient in a hospital, recovering from poison gas. This paper looks at the possible relationship of von Economo's encephalitis to Hitler's asocial behavior; his obsessions and compulsions, his cruelty and rages. The influence of Hitler's parkinsonism on his conduct during World War II is discussed.

A half-baked solution: drivers of water crises in Mexico

Science.gov (United States)

Godinez Madrigal, Jonatan; van der Zaag, Pieter; van Cauwenbergh, Nora

2018-02-01

Mexico is considered a regional economic and political powerhouse because of the size of its economy, and a large population in constant growth. However, this same growth accompanied by management and governance failures are causing several water crises across the country. The paper aims at identifying and analyzing the drivers of water crises. Water authorities seem to focus solely on large infrastructural schemes to counter the looming water crises, but fail to structure a set of policies for the improvement of management and governance institutions. The paper concludes with the implications of a business-as-usual policy based on infrastructure for solving water problems, which include a non-compliance to the human right to water and sanitation, ecosystem collapses and water conflicts.

Strengthening the evidence base for health programming in humanitarian crises.

Science.gov (United States)

Ager, A; Burnham, G; Checchi, F; Gayer, M; Grais, R F; Henkens, M; Massaquoi, M B F; Nandy, R; Navarro-Colorado, C; Spiegel, P

2014-09-12

Given the growing scale and complexity of responses to humanitarian crises, it is important to develop a stronger evidence base for health interventions in such contexts. Humanitarian crises present unique challenges to rigorous and effective research, but there are substantial opportunities for scientific advance. Studies need to focus where the translation of evidence from noncrisis scenarios is not viable and on ethical ways of determining what happens in the absence of an intervention. Robust methodologies suited to crisis settings have to be developed and used to assess interventions with potential for delivery at scale. Strengthening research capacity in the low- to middle-income countries that are vulnerable to crises is also crucial. Copyright © 2014, American Association for the Advancement of Science.

Stochastic Modeling of Past Volcanic Crises

Science.gov (United States)

Woo, Gordon

2018-01-01

The statistical foundation of disaster risk analysis is past experience. From a scientific perspective, history is just one realization of what might have happened, given the randomness and chaotic dynamics of Nature. Stochastic analysis of the past is an exploratory exercise in counterfactual history, considering alternative possible scenarios. In particular, the dynamic perturbations that might have transitioned a volcano from an unrest to an eruptive state need to be considered. The stochastic modeling of past volcanic crises leads to estimates of eruption probability that can illuminate historical volcanic crisis decisions. It can also inform future economic risk management decisions in regions where there has been some volcanic unrest, but no actual eruption for at least hundreds of years. Furthermore, the availability of a library of past eruption probabilities would provide benchmark support for estimates of eruption probability in future volcanic crises.

Banking Crises, Deposit Insurance, and Market Discipline: Lessons from the Asian Crises

OpenAIRE

Kaoru Hosono; Hiroko Iwaki; Kotaro Tsuru

2005-01-01

We investigate the effectiveness of market discipline by depositors during the period of 1992-2002 in the four crisis-hit Asian countries: Indonesia, Korea, Malaysia and Thailand. In Indonesia, the crises first weakened and then strengthened market, which is consistent with the wake-up-call effect found for the Latin American crisis-hit countries (Martinez Peria and Schmukler, 2001). Unlike Indonesia, we could not find an increase in depositors' responsiveness to bank risk after the crisis in...

Estando em crise hipertensiva numa emergência hospitalar

OpenAIRE

Borenstein,Miriam Susskind; Erdmann,Alacoque Lorenzini

1994-01-01

O estudo aborda a situação de saúde do cliente que apresenta crise hipertensiva ao chegar numa emergência hospitalar. Explora dados relativos às características pessoais e clínico epidemiológicas gerais, além de hábitos de vida que nos dão uma noçãoda amplitude da problemática de estar com a saúde "em estado de emergência". Finalizando, as autoras tecem algumas considerações sobre a necessidadede ultrapassar o foco somente biológico no atendimento a clientes com crise hipertensiva, buscando n...

Gérer les grandes crises sanitaires, écologiques, politiques et économiques

CERN Document Server

Crocq, P L; Vraie, B

2009-01-01

Crises internationales, politiques, sociales, financières, économiques, pandémies, catastrophes, attentats, prises d'otages, et, plus couramment, crises dans l'entreprise... Chacune se déroule sous stress pour le dirigeant, les cadres, la population. Comment gérer ce stress et surtout prendre les bonnes décisions ? Trois experts ont mis en commun leur expérience pour élaborer ce manuel pratique des conduites à tenir, depuis l'instauration d'une culture de crise en amont jusqu'au débriefing psychologique de fin de crise. Un livre qui s'adresse à tous ceux qui, responsables de collectivités publiques ou privées, ont ou auront à affronter des situations d'urgence. Un livre clé pour se préparer à affronter l'urgence, l'imprévisible et même l'inimaginable.

Fundo público e políticas sociais na crise do capitalismo

OpenAIRE

Salvador,Evilasio

2010-01-01

A característica comum a todas as crises financeiras dos últimos trinta anos é o comparecimento do fundo público para socorrer instituições financeiras falidas durante as crises bancárias, à custa dos impostos pagos pelos cidadãos. Com a financeirização da riqueza, os mercados financeiros passam a disputar cada vez mais recursos do fundo público, impedindo a expansão dos direitos sociais. Este artigo tem por objetivo discutir a crise do capital a partir do papel exercido pelo fundo público e ...

[Crises in interpersonal relations--stimulation or blocking of mutual growth?].

Science.gov (United States)

Willi, J

1986-01-01

Time and again, couples have to cope with changes and challenges (e.g. choice of partner, marriage, childbirth and upbringing, retirement, infirmity, etc.) which cause stress and crises to their relationship. They may try to forestall such pressing changes by entering a collusion and clinging to well-established solutions. In the therapy of chronic relational crises, it has to be taken into consideration that in case of a divorce, the partners often have no real possibilities to make a new start, and that it is often more useful to support the actual coping strategies of the couple. In urgent crises, it is recommended that the therapist structures even cuts off the partners' interactions through separation or the intervention of third parties. Only when calm has been obtained should the actual conflict be treated.

A Trilogy of Unfortunate Events in China: Reflecting on the Management of Crises

OpenAIRE

Zhang A. Long; William Crandall; John Parnell

2010-01-01

In this paper, the authors address three recent organizational crises that have occurred in China; the SK-II cosmetic incident, the Sharon Stone comment on the May 2008 earthquake in China, and the melamine milk contamination crisis. Each held significant notoriety due to the crises involving major companies and an assortment of negative outcomes. After presenting an overview of each case, the authors outline their reflections on the management of these crises in relation to their cultural co...

La crise européenne. Un regard de géographe

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Yann Richard

2012-04-01

Full Text Available L’Union européenne est durement affectée par la crise des dettes souveraines. Cette crise peut être interprétée comme la conséquence de plusieurs faits importants : une absence de leadership européen, des inégalités fortes parfois anciennes entre les performances macroéconomiques des pays membres, des faiblesses structurelles déjà observables avant la crise dans certains pays. Mais le principal facteur de fragilité de l’Union européenne réside dans sa division interne. Tant que la problématique de l’intégration européenne ne sera pas appropriée par les citoyens européens eux-mêmes et tant que certaines politiques ne seront pas davantage coordonnées, l’Union restera sur le fil du rasoir. Cette crise met en lumière l’essoufflement d’un certain modèle d’intégration. Dans cet article, on explore ces problématiques avec un regard géographique.

Victorian Financial Crises and their Implications for the Future

OpenAIRE

Kenneth N Kuttner

2010-01-01

Banking crises were a relatively common occurrence in 19th century England. Like the Federal Reserve today, the Bank of England struggled to quell panics by acting as the lender of last resort, while at the same time maintaining monetary stability. This article surveys the events leading up to and the Bank's response to the four post-1844 crises, highlights some of the similarities between the Victorian era panics and the 2007–08 crisis, and draws on the 19th century experience to illustrate ...

Constituição, realidade e crise

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Wilson Antônio Steinmetz

2016-12-01

ção enquanto locus epistêmico de análise e reflexão sobre as constituições. O que muda é a descrição ou a interpretação da relação entre Constituição e realidade que cada uma das inúmeras teorias da Constituição propõe e a ênfase, descritiva ou valorativa, que se atribui aos polos da relação. Na atual quadra da história do Brasil, retomar a pesquisa e a reflexão rigorosas sobre a dialética Constituição-realidade é, se não uma imposição, muito recomendável à comunidade científica do direito, especialmente àqueles que investigam o direito como fenômeno normativo e suas projeções sobre as relações políticas e sociais. Nosso País vive aquela que talvez seja a maior crise após a redemocratização. À crise política somam-se uma crise econômica e uma crise financeira do Estado, nos três níveis da Federação. A crise política por si mesma não seria atemorizante ou ameaçadora. Desde a redemocratização em meados dos anos 1980, atravessamos crises políticas sem rupturas institucionais ou constitucionais. No pós-1988, a Constituição tem se mostrado adequada e, ao mesmo tempo, resistente às crises políticas sazonais. No entanto, há fundados motivos para supormos que a atual crise – que possui uma dimensão política, uma dimensão econômica e uma dimensão financeira – desafia e continuará desafiando a engenharia institucional e organizacional desenhada pela Constituição de 1988. Primeiro, as dimensões da crise formam uma unidade, estão profundamente imbricadas. Passados dois anos, constata-se que a solução da crise geral depende de uma solução articulada ou encadeada das três dimensões. Segundo, o País necessita de uma ampla reforma política para a qual os partidos, os grupos e as facções políticas parecem ter disposição nenhuma para convergir. Terceiro, a crise sinaliza que o Estado brasileiro, em todas as suas esferas, já não tem condições de, simultaneamente, cumprir todas as tarefas que a Constitui

Science during crisis: the application of social science during major environmental crises

Science.gov (United States)

Machlis, Gary; Ludwig, Kris; Manfredo, Michael J.; Vaske, Jerry J.; Rechkemmer, Andreas; Duke, Esther

2014-01-01

Historical and contemporary experience suggests that science plays an increasingly critical role in governmental and institutional responses to major environmental crises. Recent examples include major western wildfires (2009), the Deepwater Horizon oil spill (2010), the Fukushima nuclear accident (2011), and Hurricane Sandy (2012). The application of science during such crises has several distinctive characteristics, as well as essential requirements if it is to be useful to decision makers. these include scope conditions that include coupled natural/human systems, clear statement of uncertainties and limitations, description of cascading consequences, accurate sense of place, estimates of magnitude of impacts, identification of beneficiaries and those adversely affected, clarity and conciseness, compelling visualization and presentation, capacity to speak "truth to power", and direct access to decision makers. In this chapter, we explore the role and significance of science – including all relevant disciplines and focusing attention on the social sciences – in responding to major environmental crises. We explore several important questions: How is science during crisis distinctive? What social science is most useful during crises? What distinctive characteristics are necessary for social science to make meaningful contributions to emergency response and recovery? How might the social sciences be integrated into the strategic science needed to respond to future crises? The authors, both members of the Department of the Interior's innovative Strategic Sciences Group, describe broad principles of engagement as well as specific examples drawn from history, contemporary efforts (such as during the Deepwater Horizon oil spill), and predictions of environmental crises still to be confronted.

MEASURES AND INSTRUMENTS USED AS A RESPONSE TO CRISES IN EUROPEAN UNION - AN OVERVIEW

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FIRTESCU BOGDAN

2011-07-01

Full Text Available During latest times, financial crises have been a common occurrence in emerging market (and transition countries with negative influence for the economies. Financial crises have had negative effects on real output, work force, poverty and political instability. Latest crises (2008 that struck US become international, its consequence being received in European countries too. This paper wants to discuss some intervention measures taken in the European Union Area and some importants funds used as tools for crises fighting. The European Economic Recovery Plan and EU funding mechanisms (The European Social Fund (ESF and The European Globalization Adjustment Fund (EGF are taken into discussion.

Inflammation in Patients with Schizophrenia: the Therapeutic Benefits of Risperidone Plus Add-On Dextromethorphan

Science.gov (United States)

Chen, Shiou-Lan; Lee, Sheng-Yu; Chang, Yun-Hsuan; Chen, Shih-Heng; Chu, Chun-Hsieh; Tzeng, Nian-Sheng; Lee, I-Hui; Chen, Po-See; Yeh, Tzung Lieh; Huang, San-Yuan; Yang, Yen-Kuang; Lu, Ru-Band; Hong, Jau-Shyong

2013-01-01

Objectives Increasing evidence suggests that inflammation contributes to the etiology and progression of schizophrenia. Molecules that initiate inflammation, such as virus- and toxin-induced cytokines, are implicated in neuronal degeneration and schizophrenia-like behavior. Using therapeutic agents with anti-inflammatory or neurotrophic effects may be beneficial for treating schizophrenia. Methods One hundred healthy controls and 95 Han Chinese patients with schizophrenia were tested in this double-blind study. Their PANSS scores, plasma interleukin (IL)-1β, TNF-α and brain-derived neurotrophic factor (BDNF) levels were measured before and after pharmacological treatment. Results Pretreatment, plasma levels of IL-1β and TNF-α were significantly higher in patients with schizophrenia than in controls, but plasma BDNF levels were significantly lower. Patients were treated with the atypical antipsychotic risperidone (Risp) only or with Risp+add-on dextromethorphan (DM). PANSS scores and plasma IL-1β levels significantly decreased, but plasma TNF-α and BDNF levels significantly increased after 11 weeks of Risp treatment. Patients in the Risp+DM group showed a greater and earlier reduction of symptoms than did those in the Risp-only group. Moreover, Risp+DM treatment attenuated Risp-induced plasma increases in TNF-α. Conclusion Patients with schizophrenia had a high level of peripheral inflammation and a low level of peripheral BDNF. Long-term Risp treatment attenuated inflammation and potentiated the neurotrophic function but also produced a certain degree of toxicity. Risp+DM was more beneficial and less toxic than Risp-only treatment. PMID:22730040

Preparation of a reproducible long-acting formulation of risperidone-loaded PLGA microspheres using microfluidic method.

Science.gov (United States)

Jafarifar, Elham; Hajialyani, Marziyeh; Akbari, Mona; Rahimi, Masoud; Shokoohinia, Yalda; Fattahi, Ali

2017-09-01

The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optimizing study was carried out at different processing parameters (e.g. PLGA and surfactant concentration and flow rates ratio of outer to inner phase). The computational fluid dynamic (CFD) modeling was performed, and loading and release study were carried out. CFD simulation indicates that increasing the flow rate of aqueous phase cause to decrease the droplet size, while the change in size of microspheres did not follow a specific pattern in the experimental results. The most uniform microspheres and narrowest standard deviation (66.79 μm ± 3.32) were achieved using T-junction chip, 1% polyvinylalcohol, 1% PLGA and flow rates ratio of 20. The microfluidic-assisted microspheres were more uniform with narrower size distribution. The release of risperidone from microspheres produced by the microfluidic method was more reproducible and closer to zero-order kinetic model. The release profile of formulation with 2:1 drug-to-polymer ratio was the most favorable release, in which 41.85% release could be achieved during 24 days.

The overlapping food and economic crises

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Carmen Radu

2015-03-01

Full Text Available In this paper we are looking at the cause-effect relationship between the economic, financial, demographic and food crises. Crises are interrelated and need to be viewed together, as the effects of one crisis are or may represent causes for another crisis. The current food crisis translates today in food price increases, in the level of health of the population that does not have enough resources for a balanced diet and in obesity problems of the young generation (Romania ranks third among European countries. All these issues with immediate and direct effects over the population in our country have generated our interest to conduct a rigorous and careful observation on the development of the phenomenon of food crisis. Food crisis, its causes and consequences – aging population, the migration of the active population to other countries (especially from the rural areas and the agglomeration of the disadvantaged population in certain geographical areas, can cause social and economic imbalances.

Impact of the topology of global macroeconomic network on the spreading of economic crises.

Science.gov (United States)

Lee, Kyu-Min; Yang, Jae-Suk; Kim, Gunn; Lee, Jaesung; Goh, Kwang-Il; Kim, In-mook

2011-03-31

Throughout economic history, the global economy has experienced recurring crises. The persistent recurrence of such economic crises calls for an understanding of their generic features rather than treating them as singular events. The global economic system is a highly complex system and can best be viewed in terms of a network of interacting macroeconomic agents. In this regard, from the perspective of collective network dynamics, here we explore how the topology of the global macroeconomic network affects the patterns of spreading of economic crises. Using a simple toy model of crisis spreading, we demonstrate that an individual country's role in crisis spreading is not only dependent on its gross macroeconomic capacities, but also on its local and global connectivity profile in the context of the world economic network. We find that on one hand clustering of weak links at the regional scale can significantly aggravate the spread of crises, but on the other hand the current network structure at the global scale harbors higher tolerance of extreme crises compared to more "globalized" random networks. These results suggest that there can be a potential hidden cost in the ongoing globalization movement towards establishing less-constrained, trans-regional economic links between countries, by increasing vulnerability of the global economic system to extreme crises.

Comparison between the efficacies of Risperidone with Haloperidol in the treatment of attention-deficit hyperactivity disorder (ADHD) among preschoolers: a randomized double-blind clinical trial.

Science.gov (United States)

Riahi, Forough; Tashakori, Ashraf; Abdi, Leila

2016-09-01

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disease with a worldwide pooled prevalence of 5.29%. To compare the efficacy of Risperidone with Haloperidol in the treatment of attention-deficit hyperactivity disorder (ADHD) among 3- to 6-year-old children. In a 6-week double-blind clinical trial, the efficacy of Risperidone 0.5-2 mg with a dose of maximum Haloperidol 0.075 mg/kg was assessed in 39 children aged 3-6 years. This study was conducted at the Golestan Psychiatric Clinic (Ahvaz, Iran). Measurement tools included the Conners' Parent Rating Scale (CPRS-48), Children's Global Assessment Scale (CGAS), and the Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). Data were analyzed using the Wilcoxon, Mann-Whitney, and Fisher's exact tests in the SPSS 19. During the 6 weeks, the decline in points was seen in Conner's rating scale and in ADHD-RS score in Risperidone and Haloperidol groups (pscale, an increase of performance in both groups for six weeks was statistically significant (pscales of ADHD-RS and CPRS-48, no statistically significant difference was observed between the two treatment groups; i.e., in terms of reducing the rate during weeks of two, four, and six (p>0.05). Haloperidol and Risperidone possibly can be an acceptable treatment choice in the ADHD treatment of 3- to 6-year-old children. The trial was registered at the Iranian Registry of Clinical Trials (http://www.irct.ir) with the Irct ID: IRCT2015082623766N1. This work was financially supported by grant (ref. no.: U-93130) from the vice chancellor for Research Affairs of Ahvaz Jundishapur University of Medical Sciences.

Crises and Collective Socio-Economic Phenomena: Simple Models and Challenges

Science.gov (United States)

Bouchaud, Jean-Philippe

2013-05-01

Financial and economic history is strewn with bubbles and crashes, booms and busts, crises and upheavals of all sorts. Understanding the origin of these events is arguably one of the most important problems in economic theory. In this paper, we review recent efforts to include heterogeneities and interactions in models of decision. We argue that the so-called Random Field Ising model ( rfim) provides a unifying framework to account for many collective socio-economic phenomena that lead to sudden ruptures and crises. We discuss different models that can capture potentially destabilizing self-referential feedback loops, induced either by herding, i.e. reference to peers, or trending, i.e. reference to the past, and that account for some of the phenomenology missing in the standard models. We discuss some empirically testable predictions of these models, for example robust signatures of rfim-like herding effects, or the logarithmic decay of spatial correlations of voting patterns. One of the most striking result, inspired by statistical physics methods, is that Adam Smith's invisible hand can fail badly at solving simple coordination problems. We also insist on the issue of time-scales, that can be extremely long in some cases, and prevent socially optimal equilibria from being reached. As a theoretical challenge, the study of so-called "detailed-balance" violating decision rules is needed to decide whether conclusions based on current models (that all assume detailed-balance) are indeed robust and generic.

Estando em crise hipertensiva numa emergência hospitalar

Directory of Open Access Journals (Sweden)

Miriam Susskind Borenstein

1994-09-01

Full Text Available O estudo aborda a situação de saúde do cliente que apresenta crise hipertensiva ao chegar numa emergência hospitalar. Explora dados relativos às características pessoais e clínico epidemiológicas gerais, além de hábitos de vida que nos dão uma noçãoda amplitude da problemática de estar com a saúde "em estado de emergência". Finalizando, as autoras tecem algumas considerações sobre a necessidadede ultrapassar o foco somente biológico no atendimento a clientes com crise hipertensiva, buscando novos hábitos saudáveis de vida.

Currency crises: Is Asia different?

OpenAIRE

Diehl, Markus; Schweickert, Rainer

1998-01-01

International investors' enthusiasm with respect to growth prospects in Southeast Asia has been followed by panic. Both the outstanding economic performance of Southeast Asian economies and their ability to master adjustment challenges had led most observers of these economies to the conclusion that "Asia is different". In comparison with previous currency crises, the macroeconomic fundamentals (GDP growth, inflation, fiscal deficit, external indebtedness, domestic savings, export performance...

Greek-Turkish Crises since 1955. Implications for Greek-Turkish Conflict Management

Science.gov (United States)

1997-03-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS GREEK-TURKISH CRISES SINCE 1955. IMPLICATIONS FOR GREEK-TURKISH CONFLICT MANAGEMENT by...EU, WEU) have only to gain from a Greek-Turkish rapprochement. 14. SUBJECT TERMS GrEek-Turkish RElATiONS, CRiSiS MANAgEMENT, CONfLICT management 15...crises, because the intended outcome of mediation attempts has been regional stability instead of Greek-Turkish conflict management . Power mediation

Financial Crises and Danish Contract Law

DEFF Research Database (Denmark)

Andersen, Mads Bryde; Lookofsky, Joseph

2016-01-01

of these exceptions - e.g. with specific focus on exceptions related to the possible effects of financial crises ("Hardship") - account must also be taken of their interaction in Danish legal theory and practice, not least because Danish courts do not always specify the exact legal principle which they apply when...

Aromatic Amino Acid Decarboxylase Deficiency Not Responding to Pyridoxine and Bromocriptine Therapy: Case Report and Review of Response to Treatment

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Majid Alfadhel

2014-01-01

Full Text Available Aromatic L-amino acid decarboxylase (AADC deficiency (MIM #608643 is an autosomal recessive inborn error of monoamines. It is caused by a mutation in the DDC gene that leads to a deficiency in the AADC enzyme. The clinical features of this condition include a combination of dopamine, noradrenaline, and serotonin deficiencies, and a patient may present with hypotonia, oculogyric crises, sweating, hypersalivation, autonomic dysfunction, and progressive encephalopathy with severe developmental delay. We report the case of an 8-month-old boy who presented with the abovementioned symptoms and who was diagnosed with AADC deficiency based on clinical, biochemical, and molecular investigations. Treatment with bromocriptine and pyridoxine showed no improvement. These data support the findings observed among previously reported cohorts that showed poor response of this disease to current regimens. Alternative therapies are needed to ameliorate the clinical complications associated with this disorder.

Environmental crises in developing countries: control measures in economic sense

International Nuclear Information System (INIS)

Rayana, K.B.N.

1999-01-01

Most of the developing countries consist of similar type of problems and crises of environment. This may be due to industries vehicles, or agriculture. Referring to the Asian countries it may be due to policy, relocation of industries, different levels of economic crises etc. This study includes impact of environment vs socio, policy, population, demography. The feasibility observed as enhancement of economic status, involving local society, cost base sharing, upgrading the employment opportunities, firm steps and policies, and agenda changes and adoptions. (Author)

Families in the context of macroeconomic crises: A systematic review.

Science.gov (United States)

Fonseca, Gabriela; Cunha, Diana; Crespo, Carla; Relvas, Ana Paula

2016-09-01

The present study is a systematic review of empirical literature from the last 35 years on families' responses to economic distress in the context of macroeconomic crises. Thirty-nine studies published between 1983 and 2015 in 12 countries were identified, resulting in 3 main findings. First, economic distress was associated with negative changes in family dynamics, specifically couple relationships and parenting. Second, protective factors were found to buffer the adverse effects of economic distress on family and individual outcomes. Third, the results suggest that individual responses to macroeconomic crises may be moderated by sex. Implications for future research encompass using validated assessment instruments, including participants beyond 2-parent families with adolescent children and conducting both longitudinal and qualitative studies that focus on the processes and meanings of adaptation within this risk context. Conclusions highlighted the need to assist families dealing with macroeconomic crises' demands, encouraging the development and validation of macrosystemic intervention programs. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Collective Intelligence in Crises

DEFF Research Database (Denmark)

Büscher, Monika; Liegl, Michael; Thomas, Vanessa

2014-01-01

New practices of social media use in emergency response seem to enable broader `situation awareness' and new forms of crisis management. The scale and speed of innovation in this field engenders disruptive innovation or a reordering of social, political, economic practices of emergency response....... By examining these dynamics with the concept of social collective intelligence, important opportunities and challenges can be examined. In this chapter we focus on socio-technical aspects of social collective intelligence in crises to discuss positive and negative frictions and avenues for innovation...

ECONOMIC CRISES – GLOBAL AND LOCAL – IN REFLECTION OF POLISH PRESS

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Krzysztof Gibek

2010-01-01

Full Text Available One of the sociological features of the current economic crises had been its beginning as a media fact rather than economic reality for ordinary people in Poland. Until the very end of 2008 the offi cial strategy of Polish government was denying of present of any economic crises in Poland: “The Polish economy as well as Polish banking system are used to be healthy and in good conditions and we will be suffer a little slow done because we are not an island”. Unfortunately it occurs not to be true.Based on discourse analysis of two major Polish daily and two weekly we would like to show the evolution of narrative describing crises in global terms and particularly at the domestic market. What was the picture of global crises at the beginning of this discussion, how it supposed to affect Poland, who serve as experts and opinion givers and finally how through the language we can observe the change from ‘slow down’ to ‘crises’? This are basic questions we would like to answer in our text.

Dealing with Crises: One Principal's Experience.

Science.gov (United States)

Foley, Charles F.

1986-01-01

The principal of Concord High School (New Hampshire) recounts the 1985-86 school year's four crises--the visits of teacher-astronaut Christa McAuliffe and Secretary of Education William Bennett, the shooting of a former student, and the Challenger space shuttle explosion. The greatest challenge was resuming the normal schedule and fielding media…

Bioequivalence and pharmacokinetic evaluation of two formulations of risperidone 2 mg : an open-label, single-dose, fasting, randomized-sequence, two-way crossover study in healthy male Chinese volunteers.

Science.gov (United States)

Liu, Yun; Zhang, Meng-qi; Jia, Jing-ying; Liu, Yan-mei; Liu, Gang-yi; Li, Shui-jun; Wang, Wei; Weng, Li-ping; Yu, Chen

2013-03-01

Risperidone is a benzisoxazole derivate and is effective in the treatment of schizophrenia and other psychiatric illnesses in adults and children. Although there are a few reports in the literature regarding the pharmacokinetic characteristics of risperidone, insufficient data on its pharmacokinetic properties in a Chinese population are available. To meet the requirements for marketing a new generic product, this study was designed to compare the pharmacokinetic properties and bioequivalence of two 2 mg tablet formulations of risperidone: a newly developed generic formulation (test) and a branded formulation (reference) in healthy adult male Chinese volunteers. A single-dose, open-label, randomized-sequence, 2 × 2 crossover study was conducted in fasted healthy male Chinese volunteers. Eligible participants were randomly assigned in a 1:1 ratio to receive 1 tablet (2 mg each) of the test formulation (Risperidone tablet; Dr. Reddy's Laboratories Ltd., Hyderabad, India) or the reference formulation (Risperdal(®) tablet; Xian-Janssen Pharmaceutical Ltd., Xi-an, China), followed by a 2-week washout period and subsequent administration of the alternate formulation. The study drugs were administered after a 10-hour overnight fast. Plasma samples were collected over 96 hours. Plasma concentrations of the parent drug, risperidone, and its active metabolite, 9-hydroxy-risperidone, were analyzed by a liquid chromatography-tandem mass spectrometry method. The formulations would be considered bioequivalent if the 90% confidence intervals (CIs) of the natural log-transformed values were within the predetermined 80-125% equivalence range for the maximum plasma drug concentration (Cmax) and the area under the plasma concentration-time curve (AUC), in accordance with guidelines issued by the US Food and Drug Administration. Assessment of tolerability was based on recording of adverse events (AEs), monitoring of vital signs, electrocardiograms, and laboratory tests at baseline

An organisational coherence model to maintain employee contributions during organisational crises

OpenAIRE

Hendrik J. Pelser; Anita Bosch; Willem Schurink

2016-01-01

Orientation: Crises that threaten an organisation’s continued existence cannot be seen in isolation when considering the perception of threats to individual job security. These threats often go hand in hand with employee panic. Research purpose: The aim of this study was to establish a model to assist organisations in managing employee emotionality and panic during times of crisis. Motivation for the study: Environmental crises threaten organisations’ existence, threatening employees’...

How company responses and trusting relationships protect brand equity in times of crises

NARCIS (Netherlands)

Hegner, Sabrina; Hegner, Sabrina M.; Beldad, Ardion Daroca; Kamphuis op Heguis, Sjarlot

2014-01-01

Brands are susceptible to various forms of crises, regardless of whether a brand’s conscious deviation from socially acceptable practices or forces and activities beyond the brand’s control prompted a crisis. Undeniably, crises can have negative ramifications for the brand’s consumer relationships

Rising from the ashes : How brands and categories can overcome product-harm crises

NARCIS (Netherlands)

Cleeren, K.; van Heerde, H.J.; Dekimpe, M.G.

2013-01-01

Product-harm crises are omnipresent in today's marketplace. Such crises can cause major revenue and market-share losses, lead to costly product recalls, and destroy carefully nurtured brand equity. Moreover, some of these effects may spill over to nonaffected competitors in the category when they

A contabilidade a valor justo e a crise financeira mundial

OpenAIRE

Eric Barreto de Oliveira

2009-01-01

A contabilidade a valor justo tem sido discutida desde meados do século passado; porém, tomou força maior a partir de publicações recentes do FASB (Financial Accounting Standards Board) e do IASB (International Accounting Standards Board). Mais recentemente, em resposta à crise global de 2008, inicialmente chamada de crise do subprime, a SEC (Securities Exchange Comission), o FASB e o IASB rediscutiram exaustivamente este critério de mensuração, com o objetivo de detectar falhas que poderiam ...

Off-balance sheet exposures and banking crises in OECD countries

OpenAIRE

Barrell, R; Davis, P; Liadze, I; Karim, D

2012-01-01

Against the background of the acknowledged importance of off-balance-sheet exposures in the sub prime crisis, we seek to investigate whether this was a new phenomenon or common to earlier crises. Using a logit approach to predicting banking crises in 14 OECD countries we find a significant impact of a proxy for the ratio of banks‟ off-balance-sheet activity to total (off and on balance sheet) activity, as well as capital and liquidity ratios, the current account balance and GDP growth. These ...

FIEGARCH-M and and International Crises: A Cross-Country Analysis

DEFF Research Database (Denmark)

Zhu, Jie

We apply the fractionally integrated exponential GARCH with volatility-in-mean (FIEGARCH-M) model of Christensen, Nielsen & Zhu (2007) to estimate the risk premium after different crises occurred in major stock markets during the past two decades. The model allows keeping the long memory property......, and it is nonmonotic for different markets. Either volatility feedback or risk premium is a possible explanation for the risk factor. On the contrary, Asian financial crisis and other market-specific crises have no persistent impact on most markets....

Diferentes teorias marxistas de crise e diferentes interpretações da crise atual Different Marxist theories of crises and different interpretations of the current crisis

Directory of Open Access Journals (Sweden)

Francisco Paulo Cipolla

2012-04-01

Full Text Available Este artigo apresenta criticamente diferentes interpretações da crise atual. Orientaram a seleção das várias contribuições a representatividade das teorias marxistas clássicas de crise e a importância das novas abordagens correspondentes aos novos fenômenos em desenvolvimento no capitalismo atual. O exame crítico dessas contribuições revela uma linha divisória entre aqueles que concebem a crise como tendo sido causada pelo afluxo dos lucros da produção para as finanças (Husson e Foster /Magdoff e aqueles para os quais o aumento do crédito de consumo foi resultado de uma reestruturação dos fluxos de crédito das empresas, cada vez mais autônomas no mercado de dinheiro, às famílias assalariadas, cada vez mais dependentes do financiamento bancário. Essa linha divisória reflete a importância que o primeiro grupo adjudica à diminuição do ritmo de crescimento vis-à-vis os teóricos da School of Oriental and African Studies. A análise revela também que a atrofia da economia política leva a um abandono precoce da teoria bancária e financeira de Marx em favor dos instrumentos teóricos pós-keynesianos imediatamente disponíveis para o uso.This article is a critical survey of different interpretations of the 2007-2008 financial crises. They were chosen either because they represented classical Marxian views on crisis, such as the underconsumption or over-accumulation theories, or else because they were newly developed interpretations based on recent newly economic developments, as it is the case of the financial expropriation theory. The analysis reveals three main points of view. The first is that the cause of crisis is the stagnation of the economy and the ensuing transfer of profits from production to finance, process that caused the housing-financial bubble (Husson and Foster/Magdoff. The second view argues that it was the structural change in financial markets which led banks to increasingly rely on consumer credit

Switching to aripiprazole in outpatients with schizophrenia experiencing insufficient efficacy and/or safety/tolerability issues with risperidone: a randomized, multicentre, open-label study.

Science.gov (United States)

Ryckmans, V; Kahn, J P; Modell, S; Werner, C; McQuade, R D; Kerselaers, W; Lissens, J; Sanchez, R

2009-05-01

This study evaluated the safety/tolerability and effectiveness of aripiprazole titrated-dose versus fixed-dose switching strategies from risperidone in patients with schizophrenia experiencing insufficient efficacy and/or safety/tolerability issues. Patients were randomized to an aripiprazole titrated-dose (starting dose 5 mg/day) or fixed-dose (dose 15 mg/day) switching strategy with risperidone down-tapering. Primary endpoint was rate of discontinuation due to adverse events (AEs) during the 12-week study. Secondary endpoints included positive and negative syndrome scale (PANSS), clinical global impressions - improvement of illness scale (CGI-I), preference of medication (POM), subjective well-being under neuroleptics (SWN-K) and GEOPTE (Grupo Español para la Optimización del Tratamiento de la Esquizofrenia) scales. Rates of discontinuations due to AEs were similar between titrated-dose and fixed-dose strategies (3.5% vs. 5.0%; p=0.448). Improvements in mean PANSS total scores were similar between aripiprazole titrated-dose and fixed-dose strategies (-14.8 vs. -17.2; LOCF), as were mean CGI-I scores (2.9 vs. 2.8; p=0.425; LOCF) and SWN-K scores (+8.6 vs.+10.3; OC,+7.8 vs.+9.8; LOCF). Switching can be effectively and safely achieved through a titrated-dose or fixed-dose switching strategy for aripiprazole, with down-titration of risperidone.

Crises Management in the Oil and Gas Industry: The Niger Delta Experience

Science.gov (United States)

Odemene, Glory C.

The Niger Delta crises escalated beyond the borders of the Nigerian nation to become an issue that affected individuals and corporations around the world. This study led to the discovery of how the local crises escalated with international implications. This discovery was accomplished by addressing how the Niger Delta crises escalated from villages to international scenes, with notable impacts on the environment, health, safety, security, and financial segments of local, international, private, and corporate entities. Using Sweeny's crisis decision theory and Lazarus and Folkman's coping theory, the study considered the coping strategies of community members, the decisions, and actions they took in response to the management approaches of the government and the oil and gas companies (OGCs). This qualitative study utilized historical narrative to collect data by interviewing 4 participants who lived and worked in the region during the crises. NVivo was used for manual and automatic coding of data, as well as for categorization and connection of codes. Content analysis of identified codes and categories revealed the themes and trends in the experiences narrated by participants. Findings include the root causes, trend of escalation, and management strategies of the government and the OGCs that influenced the crises. These findings will help to influence policies and practices in the region and enhance effective management of current and emerging conflicts, with possibilities of restoring stability and security in the areas and in the nation at large.

Exploring organizational crises from a legitimation perspective: Results from a computer simulation and illustrative cases

OpenAIRE

Breitsohl, Heiko

2008-01-01

Organizational crises are rare, yet they fundamentally influence the evolution of organizations. An aspect of crises deserving more attention is the interaction of organizations and their stakeholders during a crisis from a legitimation perspective. This paper presents a simulation model mapping causal relationships behind this interaction. Results suggest that the nature and timing of organizational response to crises has considerable effect on the success and duration of attempts of regaini...

Bond markets and banking crises in emerging market economies: The role of institutions

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Boukhatem Jamel

2012-01-01

Full Text Available This paper deals with the question of knowing if countries whose activity of financing is mainly bank based face crises more expensive than those where the bond markets are broader and more developed. The results of the empirical tests on a panel of emerging countries suggest that bank based financial systems are associated with crises slightly more expensive, whereas the relationship between the bond markets and the crises’ costs is fragile. Moreover, financial systems where bond markets play an important role are associated with a higher growth of the production, and this, independently of the presence or not of crises. The consideration of the combined effect of financial liberalization and institutional framework on the bond markets development shows the importance of the direction of the financial liberalization. We join in this case one of the most significant aspects of the “sequencing” theorized by McKinnon (1973. Finally, an effective prudential regulation tends to reduce significantly the probability of occurrence of banking crises.

Introduction: evidence-based action in humanitarian crises

NARCIS (Netherlands)

Dijkzeul, D.; Hilhorst, D.; Walker, P.

2013-01-01

This introductory paper sets the stage for this special issue of Disasters on evidence-based action in humanitarian crises. It reviews definition(s) of evidence and it examines the different disciplinary and methodological approaches to collecting and analysing evidence. In humanitarian action, the

Diversification at Financial Institutions and Systemic Crises

NARCIS (Netherlands)

Wagner, W.B.

2006-01-01

We show that the diversification of risks at financial institutions has unwelcome effects by increasing the likelihood of systems crises.As a result, complete diversification is not warranted adn the optimal degree of diversification is arbitrarily low.We also identify externalities that cause

Crises cambiais e financeiras: uma comparação entre América Latina e Leste Asiático Financial and currency crises: comparing Latin America and East Asia

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Dante Mendes Aldrighi

2009-04-01

Full Text Available Este artigo investiga as fontes de vulnerabilidade e o grau de severidade das crises cambiais e financeiras na América Latina e no Leste Asiático. Evidências obtidas a partir de um conjunto de indicadores calculados por país e por região para cada ano entre 1990 e 2004 sugerem que as economias do Leste Asiático eram potencialmente mais vulneráveis em aspectos relacionados ao setor bancário, enquanto as fragilidades das economias latino-americanas concentravam-se nos desequilíbrios fiscais e nas transações correntes do balanço de pagamentos. Por sua vez, estimativas do grau de severidade das crises mostram que, embora atenuadas na crise asiática de 1997-1998, as diferenças regionais persistiam.This article focuses on the sources of vulnerability to currency and financial crises as well as on their degree of severity in Latin American and East Asian economies. Evidence based on a number of indicators reckoned for each country and for each region for every year over the period 1990-2004 suggests that the East Asian economies were potentially more vulnerable to troubles in the banking sector, while Latin American economies' weaknesses seem to be concentrated on fiscal and current account imbalances. Furthermore, the severity crisis indicators point out that there still remained regional contrasts, lessened only during the 1997-1998 Asian crises.

[Public health crises in a developed society. Successes and limitations in Spain. SESPAS report 2010].

Science.gov (United States)

Gérvas, Juan; Meneu, Ricard

2010-12-01

The perception, acceptability and management of risks are social construction. Consequently, in managing public health crises, the gap between facts, beliefs and feelings tests the responsiveness of official institutions to health alarms that can be objective, potential, or imaginary. On balance, a strong point of the Spanish experience of health crises is the presence of clinicians and public health officers working in an organization capable of responding adequately, although the quasi-federal Spanish political structure has both advantages and disadvantages. Weaknesses include the low profile given to public health and a management structure that relies too heavily on partitocracy. The management of these crises could be improved by transferring greater scope to health professionals in decisions about crisis identification and management (with transparency) and limiting bureaucratic inertia. For some, health crises involve visibility or business opportunities (not always legitimate). Therefore, the perception of crisis will increasingly rest less in the hands of experts and more in those of groups interested in spreading these crises or in providing solutions. While progress is needed to develop participation in strategies to respond to emerging crises, even more essential is the involvement of all healthcare levels in their preparation and dissemination. Copyright © 2010 SESPAS. Published by Elsevier Espana. All rights reserved.

Political Parties and Social Policy Responses to Global Economic Crises

DEFF Research Database (Denmark)

Starke, Peter; Kaasch, Alexandra; van Hooren, Franca

2014-01-01

Based on empirical findings froma comparative study onwelfare state responses to the four major economic shocks (the 1970s oil shocks, the early 1990s recession, the 2008 financial crisis) in four OECD countries, this article demonstrates that, in contrast to conventional wisdom, policy responses...... to global economic crises vary significantly across countries. What explains the cross-national and within-case variation in responses to crises?We discuss several potential causes of this pattern and argue that political parties and the party composition of governments can play a key role in shaping crisis...

The impact of financial crises on the risk-return tradeoff and the leverage effect

DEFF Research Database (Denmark)

Christensen, Bent Jesper; Nielsen, Morten Ørregaard; Zhu, Jie

50% in magnitude during …financial crises. No such changes are observed during NBER recessions, so in this sense …financial crises are special. Applications to a number of major developed and emerging international stock markets confirm the increase in the leverage effect, whereas the international......We investigate the impact of financial crises on two fundamental features of stock returns, namely, the risk-return tradeoff and the leverage effect. We apply the fractionally integrated exponential GARCH-in-mean (FIEGARCH-M) model for daily stock return data, which includes both features...... and allows the co-existence of long memory in volatility and short memory in returns. We extend this model to allow the financial parameters governing the volatility-in-mean effect and the leverage effect to change during financial crises. An application to the daily U.S. stock index return series from 1926...

The impact of financial crises on the risk-return tradeoff and the leverage effect

DEFF Research Database (Denmark)

Christensen, Bent Jesper; Nielsen, Morten Ørregaard; Zhu, Jie

2015-01-01

% in magnitude during financial crises. No such changes are observed during NBER recessions, so in this sense financial crises are special. Applications to a number of major developed and emerging international stock markets confirm the increase in the leverage effect, whereas the international evidence......We investigate the impact of financial crises on two fundamental features of stock returns, namely, the risk-return tradeoff and the leverage effect. We apply the fractionally integrated exponential GARCH-in-mean (FIEGARCH-M) model for daily stock return data, which includes both features...... and allows the co-existence of long memory in volatility and short memory in returns. We extend this model to allow the financial parameters governing the volatility-in-mean effect and the leverage effect to change during financial crises. An application to the daily U.S. stock index return series from 1926...

Identity and intimacy crises and their relationship to internet dependence among college students.

Science.gov (United States)

Huang, Ya-Rong

2006-10-01

In an attempt to test Kandell's proposition that internet dependents used the internet as a coping mechanism against underlying psychological issues, this study investigated the extent to which the fifth and sixth Eriksonian crises (identity, intimacy), were related to internet dependence (online chatting, gaming) among college students. Students spending more than 10 hours per week on chatting/gaming were classified as dependents. On the basis of a national sample of freshmen in Taiwan, this study found that the dependents scored significantly lower on most of the measures that reflected the successful resolution of the crises, and higher on the measures that reflected unsuccessful resolution of the crises. Kandell's proposition was supported.

Gestão de crise e seu impacto na imagem de marca

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Alexandre Borba Salvador

Full Text Available Resumo: Crises de marca, decorrentes de falhas no produto, têm se tornado mais frequentes em razão do aumento da complexidade dos produtos. As crises geradas por campanhas de recall são únicas, inesperadas e podem gerar deterioração da relação favorável estabelecida entre a marca e o consumidor, afetar a imagem de marca e reduzir o brand equity. Suas consequências envolvem prejuízos financeiros de curto e longo prazo para a marca, para a empresa e, eventualmente, para a categoria como um todo. Este artigo é fruto de uma pesquisa exploratória qualitativa realizada por meio de um estudo de caso único na indústria de alimentos. Seu objetivo é verificar empiricamente a aplicação das teorias sobre crise de marca e recall em um caso brasileiro recente. Os resultados encontrados estão alinhados com as suposições elaboradas com base no referencial teórico. Como contribuição adicional para o tema, o estudo apresenta o efeito de uma crise real ao longo do tempo.

Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study.

Science.gov (United States)

Ustohal, Libor; Mayerova, Michaela; Hublova, Veronika; Prikrylova Kucerova, Hana; Ceskova, Eva; Kasparek, Tomas

2017-04-01

Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABA B ) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). We obtained data from 12 patients who showed a significant increase in CSP, from 134.20±41.81 ms to 162.95±61.98 ms ( p=0.041; Cohen's d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores ( pschizophrenia demonstrated an association between risperidone monotherapy and an increase in GABA B mediated inhibitory neurotransmission.

The dynamics of business investment following banking crises and normal recessions

OpenAIRE

Jannsen, Nils

2015-01-01

I empirically analyze the dynamics of business investment following normal recessions (declines in business investment that are not associated with banking crises) and banking crises. Using a panel of 16 advanced economies, I find evidence for significant non-linear trend reversion or bounce-back effects on the level of business investment following normal recessions, i.e., the deeper the previous recession was, the higher the growth rate of business investment will be. The trend reversion ef...

Private Inflows when Crises are Anticipated: A Case Study of Korea

OpenAIRE

Michael P. Dooley; Inseok Shin

2000-01-01

Models of financial crises based on distortions in capital markets have strong implications for the behavior of investors leading up to crises. In this paper we evaluate the hypothesis that deregulation of financial markets in Korea provided the incentives and opportunities for a sequence of capital inflows and crisis. We show that deregulation was associated with a sharp declines in the franchise value of Korean banks. Banks responded by expanding their balance sheets and accumulating high r...

Impact of crises on the development of tourism in the world

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Milićević Snežana

2016-01-01

Full Text Available In terms of global tourism business, tourism constantly faces crises that affect its development. At the beginning of the XXI century, several significant crises have had a negative effect on the world tourism industry, starting with the terrorist attacks on the USA, epidemics, the global economic crisis, natural disasters, political crises, etc. Tourism has resulted in the decline in tourism traffic and tourism receipts, with major or minor impacts on global tourism trends. The largest negative effects realized under the influence of global economic crisis, when the indicators of tourism development were poor throughout the world. To adequately manage the crisis in tourism, certain preventive measures are introduced so as to forestall the outbreak of the crisis and mitigate the negative effects upon its outbreak. Regardless of the type and duration of the crisis events, tourism has so far shown remarkable resilience.

Obsessive-compulsive symptoms during treatment with olanzapine and risperidone: A prospective study of 113 patients with recent-onset schizophrenia or related disorders

NARCIS (Netherlands)

de Haan, Lieuwe; Beuk, Nico; Hoogenboom, Britt; Dingemans, Peter; Linszen, Don

2002-01-01

Objective: To determine whether severity of obsessive-compulsive symptoms (OCS) differs during treatment with olanzapine or risperidone and to establish whether duration of antipsychotic treatment is related to severity of OCS. Method: We conducted a prospective study of consecutively hospitalized

Crises in a dissipative bouncing ball model

Energy Technology Data Exchange (ETDEWEB)

Livorati, André L.P., E-mail: livorati@usp.br [Departamento de Física, UNESP, Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil); School of Mathematics, University of Bristol, Bristol, BS8 1TW (United Kingdom); Instituto de Física, IFUSP, Universidade de São Paulo, USP, Rua do Matão, Tr.R 187, Cidade Universitária, 05314-970, São Paulo, SP (Brazil); Caldas, Iberê L. [Instituto de Física, IFUSP, Universidade de São Paulo, USP, Rua do Matão, Tr.R 187, Cidade Universitária, 05314-970, São Paulo, SP (Brazil); Dettmann, Carl P. [School of Mathematics, University of Bristol, Bristol, BS8 1TW (United Kingdom); Leonel, Edson D. [Departamento de Física, UNESP, Universidade Estadual Paulista, Av. 24A, 1515, Bela Vista, 13506-900, Rio Claro, SP (Brazil)

2015-11-06

Highlights: • We studied a dissipative bouncing ball dynamics. • A two-dimensional nonlinear mapping describes the dynamics. • Crises between attractors and its manifolds were characterized. • A new physical crisis between vibrating platform and an attractor was characterized. • The existence of a ‘robust’ chaotic attractor was set. - Abstract: The dynamics of a bouncing ball model under the influence of dissipation is investigated by using a two-dimensional nonlinear mapping. When high dissipation is considered, the dynamics evolves to different attractors. The evolution of the basins of the attracting fixed points is characterized, as we vary the control parameters. Crises between the attractors and their boundaries are observed. We found that the multiple attractors are intertwined, and when the boundary crisis between their stable and unstable manifolds occurs, it creates a successive mechanism of destruction for all attractors originated by the sinks. Also, a physical impact crisis is described, an important mechanism in the reduction of the number of attractors.

Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor

DEFF Research Database (Denmark)

Fink-Jensen, Anders; Schmidt, Lene S; Dencker, Ditte

2011-01-01

of the striatum, suggesting a role for muscarinic M4 receptors in the motor side effects of antipsychotics, and in the alleviation of these side effects by anticholinergics. Here we investigated the potential role of the muscarinic M4 receptor in catalepsy induced by antipsychotics (haloperidol and risperidone...

Conspicuous by Their Absence: Studies Comparing and Combining Risperidone and Applied Behavior Analysis to Reduce Challenging Behavior in Children with Autism

Science.gov (United States)

Weeden, Marc; Ehrhardt, Kristal; Poling, Alan

2009-01-01

Both risperidone, an atypical antipsychotic drug, and function-based behavior-analytic interventions are popular and empirically validated treatments for reducing challenging behavior in children with autism. The kind of research that supports their effectiveness differs, however, and no published study has directly compared their effects or…

COMUNIDADES VIRTUAIS COMO POTENCIALIZADORAS DE CRISES DE IMAGEM ORGANIZACIONAL

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Luís Henrique Rauber

2007-01-01

Full Text Available O presente artigo propõe discutir a importância do uso das comunidades virtuais na atualidade e sua relação com as crises de imagem nas organizações. Entendendo que o público usuário das marcas (cliente-consumidor, a partir do contato e da possibilidade de interação com estas comunidades virtuais, pode opinar e, também, receber informações sobre os produtos e serviços (sejam estas positivas ou negativas, estabelecer-se-ão exemplos de como isso ocorre, mencionando a comunidade virtual oficial da Coca-Cola na rede social Orkut. PALAVRAS-CHAVE: Comunidades virtuais. Crises de imagem. Rede social. Publicidade. Coca-Cola.

Currency crises and the interest rate defence

NARCIS (Netherlands)

Daniëls, T.

2008-01-01

While virtually all modern models of exchange rate crises recognise that the decision to abandon an exchange rate peg depends on how harshly policy makers are willing to defend the regime, they virtually never model how the exchange rate is defended. We argue that incorporating both the mechanics of

Resenha crítica - a literatura convencional sobre crises financeiras nos países "emergentes": os modelos desenvolvidos nos anos 90

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Daniela Magalhães Prates

2005-06-01

Full Text Available As sucessivas crises financeiras dos países "emergentes", na segunda metade dos anos 90, despertaram o interesse dos economistas do mainstream, uma vez que os modelos de crises cambiais de primeira geração, desenvolvidos nos anos 80, revelaram-se insuficientes para a compreensão destes eventos. Nesse contexto, foram desenvolvidos novos modelos que incorporaram, como condicionantes destas crises, fatos estilizados, que têm caracterizado o sistema financeiro internacional contemporâneo, dentre os quais os ataques especulativos auto-realizáveis e o comportamento de manada dos investidores estrangeiros. Este artigo pretende apresentar as principais características desses novos modelos. Primeiramente, apresentam-se os modelos desenvolvidos após a crise mexicana, que seguiram a tradição dos modelos de segunda geração desenvolvidos após a crise do Sistema Monetário Europeu. Em seguida, são examinados os modelos que surgem após a crise asiática, denominados "modelos de terceira geração", nos quais a crise cambial está intrinsecamente associada a uma crise bancária. Seguem-se algumas considerações finais.In the 90s, the succession of financial crises in the so called "emergent countries", with characteristics that haven't been considered by the first-generation models of exchange crises developed in the 80s, was followed by the emergency of new models of exchange crisis. The purpose of this article is to present these models, which have introduced in their analytical framework new elements, how the self-fulfilling expectations and the volatility of the capital flows. Firstly, we analyze the models developed after the Mexican crise, which have followed the tradition of the second-generation models that emerged after the European monetary system crise. Secondly, we examine the models developed after the Asian crise, labeled "third generation models", in which the exchange crise is intrinsically linked with a banking crise. We end up

The Keynesian Approach of Business Cycle and Economic Crises and its Criticism

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Ionela Bălțătescu

2009-10-01

Full Text Available The main purpose of this article is to briefly present the Keynesian explanation of business cycle, economic fluctuation and crises, and also the solutions proposed from Keynesian perspective to the economic problems that characterize the bust phases of the business cycles (unemployment, recessions. In the fourth section of the article some criticisms of the Keynesian theoretical approach of the economic crises are considered and summarized.

Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan.

Science.gov (United States)

Hsu, Wen-Yu; Huang, Si-Sheng; Lee, Bo-Shyan; Chiu, Nan-Ying

2010-06-01

The purpose of this study was to compare efficacy and safety among intramuscular olanzapine, intramuscular haloperidol, orally disintegrating olanzapine tablets, and oral risperidone solution for agitated patients with psychosis during the first 24 hours of treatment in an acute care psychiatric ward. Forty-two inpatients from an acute care psychiatric ward of a medical center in central Taiwan were enrolled. They were randomly assigned to 1 of the 4 treatment groups (10-mg intramuscular olanzapine, 10-mg olanzapine oral disintegrating tablet, 3-mg oral risperidone solution, or 7.5-mg intramuscular haloperidol). Agitation was measured by using the excited component of the Positive and Negative Syndrome Scale (PANSS-EC), the Agitation-Calmness Evaluation Scale, and the Clinical Global Impression--Severity Scale during the first 24 hours. There were significant differences in the PANSS-EC total scores for the 4 intervention groups at 15, 30, 45, 60, 75, and 90 minutes after the initiation of treatment. More significant differences were found early in the treatment. In the post hoc analysis, the patients who received intramuscular olanzapine or orally disintegrating olanzapine tablets showed significantly greater improvement in PANSS-EC scores than did patients who received intramuscular haloperidol at points 15, 30, 45, 60, 75, and 90 minutes after injection. These findings suggest that intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution are as effective treatments as intramuscular haloperidol for patients with acute agitation. Intramuscular olanzapine and disintegrating olanzapine tablets are more effective than intramuscular haloperidol in the early phase of the intervention. There is no significant difference in effectiveness among intramuscular olanzapine, orally disintegrating olanzapine tablets, and oral risperidone solution.

Bank lending strategy, credit scoring and financial crises

NARCIS (Netherlands)

Dinh, T.H.T.; Kleimeier, S.; Straetmans, S.T.M.

2013-01-01

Adverse selection inherent in the bank-borrower relationship typically intensifies during crises. This problem is expecially severe in emerging markets, characterized by weak institutions and banks with poorly developed monitoring and screening abilities. Exploiting a unique sample of Vietnamese

Legitimation Crises in Premodern Worlds

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Peter N. Peregrine

2015-08-01

Full Text Available Scholars employing world-system theory have tended to examine how world-systemsdevelop and expand, while few have addressed the fragmentation or collapse of world-systems. This paper explores the conditions of world-system collapse using Habermas's concept of legitimation crisis as a starting point. The paper posits that legitimation crises are a recurring problem in world-systems and have led to collapse in a number of cases. Prehistoric North American and Pacific world-systems are used as examples.

Syndromic intellectual disability: a new phenotype caused by an aromatic amino acid decarboxylase gene (DDC) variant.

Science.gov (United States)

Graziano, Claudio; Wischmeijer, Anita; Pippucci, Tommaso; Fusco, Carlo; Diquigiovanni, Chiara; Nõukas, Margit; Sauk, Martin; Kurg, Ants; Rivieri, Francesca; Blau, Nenad; Hoffmann, Georg F; Chaubey, Alka; Schwartz, Charles E; Romeo, Giovanni; Bonora, Elena; Garavelli, Livia; Seri, Marco

2015-04-01

The causative variant in a consanguineous family in which the three patients (two siblings and a cousin) presented with intellectual disability, Marfanoid habitus, craniofacial dysmorphisms, chronic diarrhea and progressive kyphoscoliosis, has been identified through whole exome sequencing (WES) analysis. WES study identified a homozygous DDC variant in the patients, c.1123C>T, resulting in p.Arg375Cys missense substitution. Mutations in DDC cause a recessive metabolic disorder (aromatic amino acid decarboxylase, AADC, deficiency, OMIM #608643) characterized by hypotonia, oculogyric crises, excessive sweating, temperature instability, dystonia, severe neurologic dysfunction in infancy, and specific abnormalities of neurotransmitters and their metabolites in the cerebrospinal fluid (CSF). In our family, analysis of neurotransmitters and their metabolites in patient's CSF shows a pattern compatible with AADC deficiency, although the clinical signs are different from the classic form. Our work expands the phenotypic spectrum associated with DDC variants, which therefore can cause an additional novel syndrome without typical movement abnormalities. Copyright © 2015 Elsevier B.V. All rights reserved.

Governo das sociedades, custos de agência e crise financeira: que relação?

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Catarina Alexandra Alves Fernandes

2014-03-01

Full Text Available O debate sobre o governo das sociedades tem ganhado crescente relevo nos meios acadêmico e empresarial desde o fim da década de 1980. Esse maior destaque foi originado por diversos fatores, dos quais se salientam a crise na Ásia, os escândalos financeiros que assolaram grandes empresas cotadas norte-americanas e algumas empresas de auditoria e, mais recentemente, a crise financeira mundial. Embora há muito defendida a necessidade de aperfeiçoar os instrumentos existentes e de descobrir novos mecanismos, de modo a encontrar um sistema de governo das sociedades que minimize os custos de agência, a crise financeira mundial com origem nos EUA veio dar-lhe novo “fôlego”. E, agora, com especial ênfase na banca. Falhas no governo das sociedades, em particular no setor bancário, têm sido apontadas como culpadas pela crise financeira global iniciada em 2007, só comparável à Grande Depressão. Assim, este artigo pretende, em primeiro lugar, apresentar uma caracterização genérica dos mecanismos de governo das sociedades, integrando no estudo os denominados custos de agência e, em seguida, analisar tais mecanismos no setor bancário, estabelecendo uma relação entre eles e a crise financeira. A pesquisa efetuada permite demonstrar a importância dos instrumentos de governo das sociedades na minimização dos custos de agência, nomeadamente no contexto da crise financeira. Ainda que o setor bancário tenha as suas especificidades, a investigação feita indica que existe uma relação entre aqueles instrumentos e a performance dos bancos e que fragilidades no governo das sociedades determinaram em larga medida a crise financeira. 

Crises nos Anos 80: O Ceticismo Juvenil Traduzido nas Canções do Rock Brasileiro.

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Eliana Batista Ramos

2010-12-01

Full Text Available A década de 80, apelidada de “década perdida” no sentido econômico, foi vista por alguns do mesmo modo com relação à participação juvenil (política e socialmente. A principal justificativa para isso pode ser a crise mundial do período. No rastro do processo de redemocratização de muitos países da América Latina, sobravam crises econômicas, sociais e dívidas externas fabulosas. O Brasil, inserido neste processo, se viu envolvido numa crise sem precedentes. As juventudes2 urbanas do período passaram a representar a alienação, a despolitização e a falta de identificação com movimentos sociais, como já fora observado antes. Somando-se a isso, o mundo ainda enfrentava o “fantasma” da Guerra Fria e a clara percepção dos efeitos da globalização, culminando numa eminente crise de identidade que acrescentada à crise econômica, faziam do mundo um grande campo de incertezas.

Differential Long-Term Effects of Haloperidol and Risperidone on the Acquisition and Performance of Tasks of Spatial Working and Short-Term Memory and Sustained Attention in Rats

Science.gov (United States)

Hutchings, Elizabeth J.; Waller, Jennifer L.

2013-01-01

A common feature of the neuropsychiatric disorders for which antipsychotic drugs are prescribed is cognitive dysfunction, yet the effects of long-term antipsychotic treatment on cognition are largely unknown. In the current study, we evaluated the effects of long-term oral treatment with the first-generation antipsychotic haloperidol (1.0 and 2.0 mg/kg daily) and the second-generation antipsychotic risperidone (1.25 and 2.5 mg/kg daily) on the acquisition and performance of two radial-arm maze (RAM) tasks and a five-choice serial reaction-time task (5C-SRTT) in rats during days 15–60 and 84–320 days of treatment, respectively. In the RAM, neither antipsychotic significantly affected the acquisition or performance of a spatial win shift or a delayed non–match-to-position task. Conversely, in the rats administered 5C-SRTT, haloperidol was associated with profound deficits in performance, and the subjects were not able to progress through all stages of task acquisition. Depending on the dose, risperidone was associated with a greater number of trials to meet specific performance criteria during task acquisition compared with vehicle-treated controls; however, most subjects were eventually able to achieve all levels of task acquisition. Both haloperidol and risperidone also increased the number of perseverative and time-out responses during certain stages of task acquisition, and the response and reward latencies were slightly higher than controls during several stages of the study. These results in rats suggest that while long-term treatment with haloperidol or risperidone may not significantly affect spatial working or short-term memory, both antipsychotics can (depending on dose) impair sustained attention, decrease psychomotor speed, increase compulsive-type behaviors, and impair cognitive flexibility. PMID:24042161

Differential long-term effects of haloperidol and risperidone on the acquisition and performance of tasks of spatial working and short-term memory and sustained attention in rats.

Science.gov (United States)

Hutchings, Elizabeth J; Waller, Jennifer L; Terry, Alvin V

2013-12-01

A common feature of the neuropsychiatric disorders for which antipsychotic drugs are prescribed is cognitive dysfunction, yet the effects of long-term antipsychotic treatment on cognition are largely unknown. In the current study, we evaluated the effects of long-term oral treatment with the first-generation antipsychotic haloperidol (1.0 and 2.0 mg/kg daily) and the second-generation antipsychotic risperidone (1.25 and 2.5 mg/kg daily) on the acquisition and performance of two radial-arm maze (RAM) tasks and a five-choice serial reaction-time task (5C-SRTT) in rats during days 15-60 and 84-320 days of treatment, respectively. In the RAM, neither antipsychotic significantly affected the acquisition or performance of a spatial win shift or a delayed non-match-to-position task. Conversely, in the rats administered 5C-SRTT, haloperidol was associated with profound deficits in performance, and the subjects were not able to progress through all stages of task acquisition. Depending on the dose, risperidone was associated with a greater number of trials to meet specific performance criteria during task acquisition compared with vehicle-treated controls; however, most subjects were eventually able to achieve all levels of task acquisition. Both haloperidol and risperidone also increased the number of perseverative and time-out responses during certain stages of task acquisition, and the response and reward latencies were slightly higher than controls during several stages of the study. These results in rats suggest that while long-term treatment with haloperidol or risperidone may not significantly affect spatial working or short-term memory, both antipsychotics can (depending on dose) impair sustained attention, decrease psychomotor speed, increase compulsive-type behaviors, and impair cognitive flexibility.

THE IMPLICATIONS OF LIQUIDITY CRISES IN THE CONTEXT OF EMERGING CAPITAL MARKET

OpenAIRE

Felicia Ramona Birău

2012-01-01

This article aims to highlight the implications of liquidity crises in the context of emerging capital market. Capital markets, and especially emerging capital market appear to behave notably differently during periods of liquidity crises in comparison with periods of stability. The concept of emerging capital market itself is in obvious antithesis to the idea of financial equilibrium. This particular category of capital markets is characterized in a certain measure by profound institutional,...

Financial crises of the early twentieth century in Ukraine

Directory of Open Access Journals (Sweden)

S.Z. Moshenskyi

2015-12-01

Full Text Available The article analyzes the major financial crises in Ukraine at early twentieth century dealing with the crises of 1899–1902 and 1908–1910. The main attention is paid to the large-scale crisis of 1899–1902 at the new industrial region in Eastern Ukraine where numerous steel and mining companies based on massive foreign investment (mainly Belgian and French were created shortly. The general boom of new joint-stock companies and insufficient provision of these companies by state orders were the main reason of the crisis which was the reflection of the international industrial and financial crisis of those years. The author also researches the crisis of 1908–1910 in the Ukrainian sugar industry.

Greece Financial Crises and Sukuk Markets: Experience From Gulf Countries

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Aldrin Herwany

2016-12-01

Full Text Available Many studies have been carried out to investigate the impact of recent European financial crises on the performance of financial instruments in other regions. Nevertheless, there have been insufficient studies explaining such impact on Islamic financial instrument. In particular, whether Greece Financial crises have affected performance of Sukuk traded in Gulf Markets needs to be answered. This study is aimed at empirically investigating the causality of credit and liquidity risk on Sukuk Markets in Gulf economies in the period of Greece Financial Crises. We analyzed the Sukuk data by employing Granger casuality test, with all the associated vector autoregression model procedures. Our findings show that Bahrain sukuk market is cointegrated with those of Qatar and UAE in the full period observation. Meanwhile, during the crisis, Qatar Sukuk market is cointegrated with those of UAE Bahrain. We also find that Bahrain Sukuk triggers market shock in both Qatar and UAE Sukuk markets. Bahrain consistently causes changes in price and spread of UAE Sukuk, both in the context of the full period and the during-crisis period.DOI: 10.15408/aiq.v9i1.3733

[Autonomic-vascular and visceral crises in patients with climacteric spondylopathy].

Science.gov (United States)

Altukhova, A I

1977-01-01

The paper deals with the results of observations over 62 patients (55 females and 7 males) from the age of 42-76 with climacteric spondilopathy. The following syndromes of the nervous system lesions were revealed: neuralgic syndrome, middle and lower thoracal radiculoneuritis, the syndrome of vegetative sympatoganglionitis, myelopathy. Special attetion was given to the specificity of the nervous system lesions in patients with climacteric spondilopathy which was characterized by a tendency to vegetative-visceral crises. The author recommends a scheme of a comprehensive treatment of patients with climacteric spondilopathy with vegetative-vascular and visceral crises. This treatment includes androgen-estrogen preparations, anabolic steroids, thyrocalcitonine and symptomatic treatment.

Financial Policies and the Prevention of Financial Crises in Emerging Market Countries

OpenAIRE

Frederic S. Mishkin

2001-01-01

This paper outlines a set of financial policies that can help make financial crises less likely in emerging market countries. To justify these policies, the paper first explains what a financial crisis is, the factors that promote a financial crisis and the dynamics of a financial crisis. It then examines twelve basic areas of financial policies to prevent financial crises: 1) prudential supervision, 2) accounting and disclosure requirements, 3) legal and judicial systems, 4) market-based dis...

The Framing of Humanitarian Crises in the Spanish Media: An Inductive Approach

OpenAIRE

Alberto Ardèvol-Abreu

2016-01-01

The media are important actors in humanitarian crisis management and resolution, both in the countries facing the crises and in the rest of the world. Based on an inductive approach to a news sample from four Spanish newspapers, this study analyses the news frames used in the coverage of countries facing humanitarian crises. Results show that, with certain differences between countries, the Spanish press frames these countries as being theatres of war and violence, Islamic terrorism, and crim...

Economy Over Security: Why Crises Fail to Impact Economic Behavior in East Asia

Science.gov (United States)

2017-12-01

SECURITY: WHY CRISES FAIL TO IMPACT ECONOMIC BEHAVIOR IN EAST ASIA by Aaron R. Sipos December 2017 Thesis Advisor: Michael Glosny Second...REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE ECONOMY OVER SECURITY: WHY CRISES FAIL TO IMPACT ECONOMIC BEHAVIOR IN EAST...release. Distribution is unlimited. 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) This study examines changes in economic behavior in

Analiyzing Main Determinant of Currency, Debt and Banking Crises and Frag ilities in Turkey

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Murat Türker

2015-09-01

Full Text Available The basic lessons obtained from financial turbulences all over the wor ld are the need to spot main causes, identify the triggering risk factors and consequently develop resolution plans for the potential financial crises, which include the establishment of a sound and strong financial system with strengthened institutional and structural bodies. Accurately and timely detection of the main causes that trigger financial fragilitiesemerging from currency, debt and banking is supposed to guide regulators to find "to the point" solutions to the fragility problems and to isolate their effects. Since in the Turkey case, financial crises were observed to occur in the form of twin crises or triplet crises, in this paper, we put forward Turkey-specific diagnoses and suggestions. Thus, the main factors that triggered financial turmoils in Turkey's last quarter century are low GDP, inadequate equity capital, insufficient bank returns, poor FX reserve, high inflation, short position-hot money policy, capital outflows, manipulative credit ratings and bank inertia, namely a trade off betweencredit transactions and risk-free investment vehicles

Alterations in brain extracellular dopamine and glycine levels following combined administration of the glycine transporter type-1 inhibitor Org-24461 and risperidone.

Science.gov (United States)

Nagy, Katalin; Marko, Bernadett; Zsilla, Gabriella; Matyus, Peter; Pallagi, Katalin; Szabo, Geza; Juranyi, Zsolt; Barkoczy, Jozsef; Levay, Gyorgy; Harsing, Laszlo G

2010-12-01

The most dominant hypotheses for the pathogenesis of schizophrenia have focused primarily upon hyperfunctional dopaminergic and hypofunctional glutamatergic neurotransmission in the central nervous system. The therapeutic efficacy of all atypical antipsychotics is explained in part by antagonism of the dopaminergic neurotransmission, mainly by blockade of D(2) dopamine receptors. N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia can be reversed by glycine transporter type-1 (GlyT-1) inhibitors, which regulate glycine concentrations at the vicinity of NMDA receptors. Combined drug administration with D(2) dopamine receptor blockade and activation of hypofunctional NMDA receptors may be needed for a more effective treatment of positive and negative symptoms and the accompanied cognitive deficit in schizophrenia. To investigate this type of combined drug administration, rats were treated with the atypical antipsychotic risperidone together with the GlyT-1 inhibitor Org-24461. Brain microdialysis was applied in the striatum of conscious rats and determinations of extracellular dopamine, DOPAC, HVA, glycine, glutamate, and serine concentrations were carried out using HPLC/electrochemistry. Risperidone increased extracellular concentrations of dopamine but failed to influence those of glycine or glutamate measured in microdialysis samples. Org-24461 injection reduced extracellular dopamine concentrations and elevated extracellular glycine levels but the concentrations of serine and glutamate were not changed. When risperidone and Org-24461 were added in combination, a decrease in extracellular dopamine concentrations was accompanied with sustained elevation of extracellular glycine levels. Interestingly, the extracellular concentrations of glutamate were also enhanced. Our data indicate that coadministration of an antipsychotic with a GlyT-1 inhibitor may normalize hypofunctional NMDA receptor-mediated glutamatergic neurotransmission with reduced

Financial Crises and Automotive Industry Development in Southeast Asia

DEFF Research Database (Denmark)

Doner, Richard F.; Wad, Peter

2014-01-01

The automotive industries of Southeast Asia have grown significantly but unevenly. Thailand has outperformed its neighbours in Malaysia, Indonesia and the Philippines with regard to production and, most notably, export volumes. But the Thai auto industry has not exhibited the level of local...... (indigenous) technology capacity and input growth seen in South Korea, Taiwan and, increasingly, in China. The 1997–98 and 2008 financial and economic crises generally reinforced pre-existing national automotive strategies, but to different degrees: They strongly accelerated an earlier Thai move to exports...... whose very success weakened pressures for upgrading; encouraged more moderate automotive liberalisation in Indonesia and, to a lesser extent, in the Philippines; but promoted only minimal changes to Malaysia’s relatively protectionist national car strategy. The fact that the crises served more...

Early Life Crises of Habitable Planets

International Nuclear Information System (INIS)

Pierrehumbert, Raymond

2006-01-01

There are a number of crises that a potentially habitable planet must avoid or surmount if its potential is to be realized. These include the runaway greenhouse, loss of atmosphere by chemical or physical processes, and long-lasting global glaciation. In this lecture I will present research on the climate dynamics governing such processes, with particular emphasis on the lessons to be learned from the cases of Early Mars and the Neoproterozoic Snowball Earth.

Piracetam for reducing the incidence of painful sickle cell disease crises.

Science.gov (United States)

Al Hajeri, Amani; Fedorowicz, Zbys

2016-02-12

Sickle cell disease is one of the most common genetic disorders. Sickle cell crises in which irregular and dehydrated cells contribute to blocking of blood vessels are characterised by episodes of pain. Treatment is mainly supportive and symptomatic. In vitro studies with piracetam indicate that it has the potential for inhibition and a reversal of the process of sickling of erythrocytes. This is an update of a previously published Cochrane review. To assess the effectiveness of piracetam for reducing the incidence of painful sickle cell disease crises. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Last search of the Group's Haemoglobinopathies Trials Register: 21 September 2015. Randomised controlled trials comparing orally administered piracetam to placebo or standard care in people, of all ages and both sexes, with sickle cell disease. Two authors independently assessed trial quality and extracted data. Trial authors were contacted for additional information. Adverse effects data were collected from the trials. Three trials involving 169 participants were included in the review. A limited amount of data addressing some of the primary and some of the secondary outcomes were provided, but data were incomplete and based on un-validated assumptions used in the evaluation of outcomes. One trial reported a reduction in the number of pain crises and their severity with active intervention than placebo but presented no data to confirm these results. A second trial presented a monthly global pain score based on the number of sickle cell crises and severity of pain but included no separate data for these primary outcomes. Although there was no significant difference between the piracetam and placebo periods for the number of days of

A crise econômica de 2014/2017

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Fernando de Holanda Barbosa Filho

Full Text Available Resumo Este artigo mostra que a crise de 2014/2017 é fruto de uma combinação de choques de oferta e demanda resultado de erros de política econômica. Esses choques produziram uma redução da capacidade de crescimento da economia brasileira e risco de insolvência das finanças públicas. A solução da crise fiscal, através da PEC do teto dos gastos, fará que o país retome o crescimento econômico a partir de 2017, utilizando a capacidade ociosa da economia. No entanto, a taxa de crescimento do produto potencial não recuperará o ritmo anterior devido aos efeitos duradouros das políticas da Nova Matriz Econômica (NME que reduziram o produto potencial nacional. Recomenda-se, portanto, a adoção de políticas que induzam uma recuperação da produtividade da economia brasileira.

O impacto da crise financeira de 2008 no sector corticeiro português : caso Corticeira Amorim

OpenAIRE

Basto, Joana Salema Pinto

2010-01-01

Mestrado em Finanças O presente trabalho estuda o efeito que a crise económica e financeira teve nas rendibilidades anuais da empresa Corticeira Amorim e nos seus indicadores financeiros. É feita uma análise das rendibilidades em bolsa da Corticeira Amorim e seus benchmarks no período pré-crise (2005-2007) e no período pós-crise (2008-2010). Considera-se ainda o estudo da influência de algumas variáveis macroeconómicas (taxa de inflação, taxa de juro, taxa de câmbio euro dólar, preço do pe...

A Double-Blind, Placebo-Controlled Study of Risperidone for the Treatment of Adolescents and Young Adults with Anorexia Nervosa: A Pilot Study

Science.gov (United States)

Hagman, Jennifer; Gralla, Jane; Sigel, Eric; Ellert, Swan; Dodge, Mindy; Gardner, Rick; O'Lonergan, Teri; Frank, Guido; Wamboldt, Marianne Z.

2011-01-01

Objective: The purpose of this double-blind, placebo-controlled exploratory pilot study was to evaluate the safety and efficacy of risperidone for the treatment of anorexia nervosa. Method: Forty female subjects 12 to 21 years of age (mean, 16 years) with primary anorexia nervosa in an eating disorders program were randomized to receive…

O Enquadramento da Crise Hídrica na Revista Veja

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Andrea Reis

2016-01-01

Full Text Available O artigo tem por objetivo estudar o enquadramento midiático construído em torno da crise hídrica que se instalou no Estado de São Paulo, com maior período de seca entre os anos de 2014 e 2015. No intuito de analisar como o tema foi retratado pelos meios de comunicação, a revista Veja foi eleita objeto deste estudo, que pretende elencar como ocorreu o enquadramento da crise e as atribuições de responsabilidade veiculadas por essa mídia, ao governador reeleito Geraldo Alckmin (PSDB, a Companhia de Saneamento Básico do Estado de São Paulo (Sabesp, aos cidadãos e ao meio ambiente, no período de 1º de janeiro a 31 de março de 2015.

A crise em perspectiva: 1929 e 2008

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Frederico Mazzucchelli

2008-11-01

Full Text Available No contexto de elevada incerteza decorrente da crise econômica mundial, é inevitável que surjam comparações entre o momento atual e a experiência dramática da Grande Depressão, que subverteu o mundo entre 1929 e 1933. Mas, apesar das perdas financeiras e da desaceleração da economia, a disposição para a intervenção estatal é hoje um elemento determinante que diferencia nitidamente as iniciativas da política econômica. Este é um fator decisivo que projeta um futuro menos sombrio para a evolução da crise atual.In the current context of high uncertainty, many parallels have been traced between the economic crisis of 2008 and the Great Depression, that stirred the world between 1929 e 1933. However, despite the financial losses that recently occurred, the disposition for state intervention in our days is much higher and thus an important element in the formulation of economic policies. This is a difference that suggests a less catastrophic outcome to the current crisis.

Influence of Aripiprazole, Risperidone, and Amisulpride on Sensory and Sensorimotor Gating in Healthy ‘Low and High Gating' Humans and Relation to Psychometry

Science.gov (United States)

Csomor, Philipp A; Preller, Katrin H; Geyer, Mark A; Studerus, Erich; Huber, Theodor; Vollenweider, Franz X

2014-01-01

Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds without antipsychotic properties served as negative control treatments. In a placebo-controlled, within-subject design, healthy males received either single doses of aripiprazole and risperidone (n=28), amisulpride and lorazepam (n=30), or modafinil and valproate (n=30), and placebo. Prepulse inhibiton (PPI) and P50 suppression were assessed. Clinically associated symptoms were evaluated using the SCL-90-R. Aripiprazole, risperidone, and amisulpride increased P50 suppression in low P50 gaters. Lorazepam, modafinil, and valproate did not influence P50 suppression in low gaters. Furthermore, low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters. Aripiprazole increased PPI in low PPI gaters, whereas modafinil and lorazepam attenuated PPI in both groups. Risperidone, amisulpride, and valproate did not influence PPI. P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker. This conclusion is supported by the association of low P50 suppression and higher clinically associated scores. Furthermore, PPI might be sensitive for atypical mechanisms of antipsychotic medication. The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making. PMID:24801767

Resilience of natural gas networks during conflicts, crises and disruptions.

Directory of Open Access Journals (Sweden)

Rui Carvalho

Full Text Available Human conflict, geopolitical crises, terrorist attacks, and natural disasters can turn large parts of energy distribution networks offline. Europe's current gas supply network is largely dependent on deliveries from Russia and North Africa, creating vulnerabilities to social and political instabilities. During crises, less delivery may mean greater congestion, as the pipeline network is used in ways it has not been designed for. Given the importance of the security of natural gas supply, we develop a model to handle network congestion on various geographical scales. We offer a resilient response strategy to energy shortages and quantify its effectiveness for a variety of relevant scenarios. In essence, Europe's gas supply can be made robust even to major supply disruptions, if a fair distribution strategy is applied.

Homo sapiens, Homo demens e Homo degradandis: a psiquê humana e a crise ambiental

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Alessandra Bortoni Ninis

2012-04-01

Full Text Available Este artigo discute a crise ambiental por meio de um diálogo entre a psicanálise, filosofia e ciências sociais. Busca-se introduzir um eixo comum de compreensão das relações entre a psiquê e a natureza, a partir de um texto reflexivo sobre a natureza humana, sua complexidade e suas sociopatias. A crise socioambiental em que vivemos é tratada a partir das seguintes proposições: (i a humanidade se distanciou da sua condição natural; (ii a humanidade pode estar psicologicamente doente; (iii a humanidade não está moralmente apta para delegar a superação da crise às futuras gerações, pois vivemos num simulacro que envolve consumismo e alienação. Conclui-se que há uma dimensão subjetiva na raiz da crise ambiental, de cuja análise depende a solução real do impasse civilizacional com o qual nos defrontamos.

A Bayesian Approach to Excess Volatility, Short-term Underreaction and Long-term Overreaction during Financial Crises

NARCIS (Netherlands)

X. Guo (Xu); M.J. McAleer (Michael); W.-K. Wong (Wing-Keung); L. Zhu (Lixing)

2016-01-01

textabstractIn this paper, we introduce a new Bayesian approach to explain some market anomalies during financial crises and subsequent recovery. We assume that the earnings shock of an asset follows a random walk model with and without drift to incorporate the impact of financial crises. We further

MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of risperidone, 9-hydroxyrisperidone, monoamine and amino acid neurotransmitters in human urine.

Science.gov (United States)

Cai, Hua-Lin; Zhu, Rong-Hua; Li, Huan-De; Zhang, Jun; Li, Lan-Fang

2011-07-01

A pre-column dansylated ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-MS/MS) method for simultaneous determination of risperidone (RIP), 9-hydroxyrisperidone (9-OH-RIP), monoamine and amino acid neurotransmitters in human urine was developed with the aim of providing data on how neurotransmitters may influence each other or change simultaneously in response to risperidone treatment. MultiSimplex based on the simplex algorithm and the fuzzy set theory was applied to the optimization of chromatographic separation and dansyl derivatization conditions during method development. This method exhibited excellent linearity for all the analytes with regression coefficients higher than 0.997. The lower limit of quantification (LLOQ) values for 9-OH-RIP and RIP were 0.11 and 0.06 ng/ml, respectively, and for neurotrasmitters ranged from 0.31 to 12.8 nM. The mean accuracy ranged from 94.7% to 108.5%. The mean recovery varied between 81.6% and 97.5%. All the RSD of precision and stability were below 9.7%. Finally, the optimized method was applied to analyze the first morning urine samples of schizophrenic patients treated with risperidone and healthy volunteers. Copyright © 2011 Elsevier B.V. All rights reserved.

Vulnerability of countries to food-production crises propagating in the virtual water trade network

Science.gov (United States)

Tamea, S.; Laio, F.; Ridolfi, L.

2015-12-01

In recent years, the international trade of food and agricultural commodities has undergone a marked increase of exchanged volumes and an expansion of the trade network. This globalization of trade has both positive and negative effects, but the interconnectedness and external dependency of countries generate complex dynamics which are often difficult to understand and model. In this study we consider the volume of water used for the production of agricultural commodities, virtually exchanged among countries through commodity trade, i.e. the virtual water trade. Then, we set up a parsimonious mechanistic model describing the propagation, into the global trade network, of food-production crises generated locally by a social, economic or environmental event (such as war, economic crisis, drought, pest). The model, accounting for the network structure and the virtual water balance of all countries, bases on rules derived from observed virtual water flows and on data-based and statistically verified assumption. It is also tested on real case studies that prove its capability to capture the main features of crises propagation. The model is then employed as the basis for the development of an index of country vulnerability, measuring the exposure of countries to crises propagating in the virtual water trade network. Results of the analysis are discussed within the context of socio-economic and environmental conditions of countries, showing that not only water-scarce, but also wealthy and globalized countries, are among the most vulnerable to external crises. The temporal analysis for the period 1986-2011 reveals that the global average vulnerability has strongly increased over time, confirming the increased exposure of countries to external crises which may occur in the virtual water trade network.

Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder.

Science.gov (United States)

Lee, Brendan; Diaz, George A; Rhead, William; Lichter-Konecki, Uta; Feigenbaum, Annette; Berry, Susan A; Le Mons, Cindy; Bartley, James A; Longo, Nicola; Nagamani, Sandesh C; Berquist, William; Gallagher, Renata; Bartholomew, Dennis; Harding, Cary O; Korson, Mark S; McCandless, Shawn E; Smith, Wendy; Cederbaum, Stephen; Wong, Derek; Merritt, J Lawrence; Schulze, Andreas; Vockley, Jerry; Vockley, Gerard; Kronn, David; Zori, Roberto; Summar, Marshall; Milikien, Douglas A; Marino, Miguel; Coakley, Dion F; Mokhtarani, Masoud; Scharschmidt, Bruce F

2015-07-01

The aim of this study was to examine predictors of ammonia exposure and hyperammonemic crises in patients with urea cycle disorders. The relationships between fasting ammonia, daily ammonia exposure, and hyperammonemic crises were analyzed in >100 patients with urea cycle disorders. Fasting ammonia correlated strongly with daily ammonia exposure (r = 0.764; P 200% (P urea cycle disorder subtype, dietary protein intake, or blood urea nitrogen. Fasting glutamine correlated weakly with daily ammonia exposure assessed as 24-hour area under the curve and was not a significant predictor of hyperammonemic crisis. Fasting ammonia correlates strongly and positively with daily ammonia exposure and with the risk and rate of hyperammonemic crises, suggesting that patients with urea cycle disorder may benefit from tight ammonia control.

Letras e humanidades depois da crise

OpenAIRE

Alcir Bernardez Pecora

2015-01-01

O artigo debate a situação contemporânea das humanidades num mundo de crise econômica, onde são elas as primeiras áreas a sofrer cortes orçamentários, bem como a perda da autonomia das Universidades com o atual processo de dependência de seus programas dos fundos advindos das agências de financiamento de pesquisa acadêmica.     This work is licensed under a Creative Commons Attribution 3.0 License.

Letras e humanidades depois da crise

Directory of Open Access Journals (Sweden)

Alcir Bernardez Pecora

2015-11-01

Full Text Available O artigo debate a situação contemporânea das humanidades num mundo de crise econômica, onde são elas as primeiras áreas a sofrer cortes orçamentários, bem como a perda da autonomia das Universidades com o atual processo de dependência de seus programas dos fundos advindos das agências de financiamento de pesquisa acadêmica.     This work is licensed under a Creative Commons Attribution 3.0 License.

Re-evaluation of bone pain in patients with type 1 Gaucher disease suggests that bone crises occur in small bones as well as long bones.

Science.gov (United States)

Baris, Hagit N; Weisz Hubshman, Monika; Bar-Sever, Zvi; Kornreich, Liora; Shkalim Zemer, Vered; Cohen, Ian J

2016-09-01

Bone crises in type 1 Gaucher disease are reported in long bones and occasionally in weight bearing bones and other bones, but rarely in small bones of the hands and feet. We retrospectively examined the incidence of bone pain in patients followed at the Rabin Medical Center, Israel, before and following the initiation of enzyme replacement therapy (ERT) and evaluated them for bone crises. Of 100 type I Gaucher disease patients, 30 (30%) experienced one or more bone crises. Small bone crises represented 31.5% of all bone crises and were always preceded by crises in other bones. While the incidence of long bone crises reduced after the initiation of ERT, small bone crises increased. Almost 60% of patients with bone crises were of the N370S/84GG genotype suggesting a greater susceptibility of N370S/84GG patients to severe bone complications. These patients also underwent the greatest number of splenectomies (70.6% of splenectomised patients). Splenectomised patients showed a trend towards increased long and small bone crises after surgery. Active investigation of acute pain in the hands and feet in patients in our cohort has revealed a high incidence of small bone crises. Physicians should consider imaging studies to investigate unexplained pain in these areas. Copyright © 2015 Elsevier Inc. All rights reserved.

Effects of 21-day d-amphetamine and risperidone treatment on cocaine vs food choice and extended-access cocaine intake in male rhesus monkeys.

Science.gov (United States)

Hutsell, Blake A; Negus, S Stevens; Banks, Matthew L

2016-11-01

Clinical trial data suggest amphetamine treatment is most efficacious in moderate to high frequency cocaine users. However, preclinical studies have examined amphetamine treatment effects under relatively limited cocaine access conditions with low to moderate cocaine intakes. This study determined d-amphetamine treatment effects on cocaine self-administration in rhesus monkeys under cocaine access conditions allowing for high daily cocaine intake. For comparison and as a negative control, treatment effects with the antipsychotic risperidone were also examined. Continuous 21-day treatments with ramping doses of d-amphetamine (days 1-7: 0.032mg/kg/h; days 8-21: 0.1mg/kg/h, i.v.) or risperidone (days 1-7: 0.001mg/kg/h; days 8-14: 0.0032mg/kg/h; days 15-21: 0.0056mg/kg/h, i.v.) were administered to rhesus monkeys (n=4) with daily access to two types of cocaine self-administration sessions: (1) a 2-h 'choice' session with concurrent availability of 1-g food pellets and intravenous cocaine injections (0-0.1mg/kg per injection) and (2) a 20-h 'extended-access' session with 0.1mg/kg per injection cocaine availability. Total daily cocaine intake increased >6-fold during extended cocaine access. d-Amphetamine significantly decreased total cocaine intake, but not cocaine vs food choice. In contrast, risperidone did not significantly alter either total cocaine intake or cocaine vs. food choice. These results confirm and extend previous results supporting treatment effectiveness for monoamine releasers, but not dopamine antagonists, to reduce cocaine self-administration. Moreover, these results suggest amphetamine treatment efficacy to decrease preclinical cocaine vs. food choice may depend upon cocaine access conditions. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique.

Science.gov (United States)

Khames, Ahmed

2017-11-01

BCS class II drugs usually suffer inadequate bioavailability as dissolution step is the absorption rate limiting step. In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using risperidone as a drug model. Liquisolid technique was applied to prepare risperidone per-oral tablets of high dissolution rate at intestinal pH (6.8) using versatile nonionic surfactants of high solubilizing ability [Transcutol HP, Labrasol and Labrasol/Labrafil (1:1) mixture] as liquid vehicles at different drug concentrations (10-30%) and fixed (R). The prepared liquisolid tablets were fully evaluated and the dissolution rate at pH 6.8 was investigated. The formulae that showed significantly different release rate were selected and subjected to mathematical modeling using DE 25 , MDT and similarity factor (f2). Depending on mathematical modeling results, formula of higher dissolution rate was subjected to solid state characterization using differential scanning calorimetric (DSC), infrared spectroscopy (IR) and X-ray diffraction (XRD). Finally, the drug bioavailability was studied in comparison to conventional tablets in rabbits. Results showed that liquisolid tablet prepared using Labrasol/Labrafil (1:1) mixture as liquid vehicle containing 10% risperidone is a compatible formula with law drug crystallinity and higher dissolution rate (100% in 25 min). The drug bioavailability was significantly increased in comparison to the conventional tablets (1441.711 μg h/mL and 137.518 μg/mL in comparison to 321.011 μg h/mL and 38.673 μg/mL for AUC and Cp max , respectively). This led to the conclusion that liquisolid technique was efficiently improved drug solubility and solubility increase of BCS class II drugs at their main absorption site significantly increases their bioavailability.

Early Warning Models for Systemic Banking Crises in Montenegro

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Željka Asanović

2013-06-01

Full Text Available The purpose of this research is to create an adequate early warning model for systemic banking crises in Montenegro. The probability of banking crisis occurrence is calculated using discrete dependent variable models, more precisely, estimating logit regression. Afterwards, seven simple logit regressions that individually have two explanatory variables are estimated. Adequate weights have been assigned to all seven regressions using the technique of Bayesian model averaging. The advantage of this technique is that it takes into account the model uncertainty by considering various combinations of models in order to minimize the author’s subjective judgment when determining reliable early warning indicators. The results of Bayesian model averaging largely coincide with the results of a previously estimated dynamic logit model. Indicators of credit expansion, thanks to their performances, have a dominant role in early warning models for systemic banking crises in Montenegro. The results have also shown that the Montenegrin banking system is significantly exposed to trends on the global level.

The Impact of the Global Commodity and Financial Crises on Poverty in Vietnam

DEFF Research Database (Denmark)

Thurlow, James; Tarp, Finn; McCoy, Simon

Economic growth in Vietnam has been fairly resilient to the global commodity and financial crises, but it is unclear why. In addition, the impact of the crises on employment and poverty is in dispute. We develop a dynamic computable general equilibrium model to decompose impacts and estimate...... distributional outcomes. Our results indicate that the 2008 commodity crisis increased employment and reduced poverty by favouring labour-intensive exports, especially in agriculture. The 2009 financial crisis reversed these gains. It pushed more than a million workers into unemployment and about 3 million...

A Crise Hídrica na Região Metropolitana de São Paulo (2014-2015

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Vanderli Custódio

2015-12-01

Full Text Available Este artigo sobre a crise hídrica na Região Metropolitana de São Paulo entre os anos 2014-2015, objetiva caracterizá-la e situá-la num contexto temporal mais amplo. Com apoio bibliográfico se intenta demonstrar que essa não é uma crise nova e sim uma nova fase de uma crise secular pela frágil gestão e planejamento no abastecimento de água para São Paulo por parte do Poder Público, bem como evidenciar que as medidas estruturais (obras e não estruturais (programas, legislação etc. possuem histórico caráter emergencial. Como resultado espera-se contribuir para o enriquecimento da abordagem da problemática.

Crises financeiras nos anos 1990 e poupança externa

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Luiz Carlos Bresser-Pereira

2008-12-01

Full Text Available Contrary to what conventional economic analysis afirms, the main cause of the financial crises in emerging countries during the 1990s, beginning with Mexico (1994 and ending with the crisis in Argentina (2001 was not primarily fiscal, but the decision by governments to foster growth with foreign savings, i.e., with current account deficits. Since the exchange rate has other determinants besides domestic absorption, the assumption of twin deficits often does not hold. These were balance of payment crises triggered by an overvalued local currency and the high increases in the foreign debt and/or the fast growth of the current account deficit. This led, foreign creditors to suddenly become persuaded that the country faced both liquidity and solvency problems, and to stop rolling over the debt. An econometric test substantiates these claims.

Risperidone, quetiapine, and olanzapine adjunctive treatments in major depression with psychotic features: a comparative study

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Gabriel A

2013-04-01

Full Text Available A Gabriel Departments of Psychiatry and Community Health Sciences, University of Calgary, Calgary, AB, Canada Objectives: The purpose of this study was to compare the effectiveness of novel antipsychotics in the treatment of psychotic depression. Method: Consecutive patients who were admitted (n = 51 with a confirmed diagnosis of major depression with psychotic features (delusions or hallucinations or both participated in this open-label, naturalistic study. All patients were treated with selective serotonin reuptake inhibitors (SSRIs and serotonin–norepinephrine reuptake inhibitors (SNRIs (citalopram or venlafaxine extended release [XR], and atypical antipsychotic agents were added, as tolerated, during the first week of initiating the citalopram or venlafaxine. There were patients (n = 16 who received risperidone, who received quetiapine (n = 20, and who received olanzapine (n = 15, as an adjunctive treatment to either citalopram or venlafaxine for at least 8 weeks. Outcome measures included the Clinical Global Impression-Severity subscale (CGI-S, as the primary outcome measure, as well as the Hamilton Rating Scale for Depression-21 item (HAM-D21 and the Brief Psychiatric Rating Scale (BPRS. Tolerance to treatments and weight changes were monitored over the period of the trial. Results: All patients completed the trial with no drop outs. At 8 weeks, there was a statistically significant (P 0.01 in the olanzapine group. Conclusion: Quetiapine, risperidone, and olanzapine, given as adjunctive treatment with SSRIS or SNRIs can significantly and equally improve depressive and psychotic symptoms, in the short-term treatment of major depression with psychotic features. The author recommends that large controlled trials be conducted to examine the differences in long-term efficacy and tolerance between the atypical antipsychotic agents, in the treatment of major depression with or without psychotic features. Keywords: depression, novels

Crise tireotóxica associada à doença trofoblástica gestacional

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Carlos Eduardo David de Almeida

2011-10-01

Full Text Available JUSTIFICATIVA E OBJETIVOS: A gonadotrofina coriônica humana (HCG e o hormônio tireotrófico (TSH apresentam analogia entre suas estruturas, assim como seus receptores. Os altos níveis de HCG encontrados nas doenças trofoblásticas gestacionais podem induzir um quadro de hipertireoidismo secundário. O objetivo deste relato é apresentar um caso em que a administração de contraste iodado precipitou um quadro de crise tireotóxica. RELATO DO CASO: Paciente com mola hidatiforme completa foi admitida no centro cirúrgico com sangramento vaginal intenso após realização de tomografia com contraste iodado. Durante indução anestésica, paciente apresentou quadro compatível com crise tireotóxica. CONCLUSÕES: A incidência de quadros graves associados à doença trofoblástica gestacional tende a diminuir com seu diagnóstico precoce. Ainda que isso aconteça, o anestesiologista deve estar atento à possibilidade de crise tireotóxica nesses pacientes.

Entrevista - Crise do Capital, disputa de destino e desafios para os trabalhadores

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Reinaldo Gonçalves

2010-05-01

Full Text Available

A saúde pública brasileira no contexto da crise do Estado ou do capitalismo?

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Áquilas Mendes

2015-06-01

Full Text Available Este artigo tem como objetivo analisar a tendência da saúde publica universal brasileira no contexto da crise estrutural do capitalismo, articulando os interesses do capital e do Estado, sem que seja possível se referir à uma crise do Estado Moderno. Para tanto, o artigo está organizado em duas partes. A primeira parte busca analisar a natureza da crise, identificando tendências do desenvolvimento do capitalismo, principalmente nas últimas décadas do século XX e na primeira década do século XXI, com destaque para a lei marxiana da queda tendencial da taxa de lucro e a dominância do capital portador de juros. A segunda parte discute os impactos dessa crise ao direito universal da saúde no Brasil, especialmente, a partir dos anos 1990, confirmando as incertezas do financiamento do SUS e o crescente movimento de apropriação do capital sobre os recursos das políticas sociais de direitos, as da seguridade social, especialmente a saúde. Por fim, são apresentadas as considerações finais, incluindo algumas propostas para enfrentar esse quadro de instabilidade e subfinanciamento desse sistema de saúde.

Risk of Hyperprolactinemia and Sexual Side Effects in Males 10-20 Years Old Diagnosed with Autism Spectrum Disorders or Disruptive Behavior Disorder and Treated with Risperidone

NARCIS (Netherlands)

Roke, Yvette; Buitelaar, Jan K.; Boot, Annemieke M.; Tenback, Diederik; van Harten, Peter N.

2012-01-01

Objective: The aim of this study was to investigate the long-term treatment effects of risperidone on prolactin levels and prolactin-related side effects in pubertal boys with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD). Method: Physical healthy 10-20-year-old males with

Governing humanitarian emergencies, protracted crises, and (in)security through resilience

NARCIS (Netherlands)

Anholt, Rosanne

2017-01-01

‘Resilience’ occupies a prominent place in contemporary discussions around the governance of humanitarian emergencies, protracted crises and insecurity more broadly. The aim of this study was to further our understanding of resilience as a governance rationality and a policy discourse, in particular

Performance of European Industry of Logistics Services Before and After Economic Crises in the Years 2008/2009

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Beti Godnič

2017-09-01

Full Text Available Abstract: In this article we examined the impact of economic crises in the years 2008/2009 on the logistics industry in old member states EU-15 and the new EU member states. The emergence of the economic crisis in 2008/2009 when the states of the old members of EU-15 and new EU member states were the first time subjected to the effects of the crisis inside the single entity-the European Union. Research question: The basic research question is: Were implications of economic crises in the years 2008/2009 in logistics industry in heterogenic states of European Union; old member states EU-15 and the new EU member states different? Purpose:We wanted to determine how the logistics companys in old member States EU (15 and in the new EU member states adapt to the new circumstances caused by economic crises in the years 2008/2009. Method: Economic crises are complex multifunctional phenomenon. Analysing complexity of the changes of the state of economic system need to supplement the pure scientific approach with other types of research work, more holistic approach, which is commonly used in Comparative economics. In this article we combine both. In empirical part we used appropriate parametric and non-parametric tests of differences between old and new member states of the European Union. We used Pearson's chi-squared test (Pearson, 1900, p. 157-175. Results: In the article we studied changes ocured by economic crises in the years 2008/2009 in the European logistics industry. We found that the logistics companies in the old EU member states EU-15 and in the new EU member states differently adapt to the implications of economic crises in the years 2008/2009. EU hasn’t adopted and implemented the harmonised economic policy, which will solve the »North-South« problem in logistics industry and find a way to operate systemically in global environment. Organization: The findings can be used to support undestanding of changed bussines envirnment of the

Charisma, volatility and violence: assessing the role of crises of charismatic authority in precipitating incidents of millenarian violence

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John Walliss

2006-01-01

Full Text Available In this article the author develops some of the points he has made elsewhere regarding the role of what may be termed ‘crises of charismatic authority’ in producing volatility or even violence within marginal apocalyptic religious groups. The last quarter of the twentieth century witnessed several incidents where such groups engaged in violent actions against themselves, others in the outside world, or typically both (among them the Peoples Temple in Guayana in 1978, Branch Davidians in Waco, Texas in 1994, Order of the Solar Temple in Switzerland, Quebec and France in 1997, Aum Shirinkyo, Japan in 1995, Movement for the Restoration of the Ten Commandments of God, Uganda in 2000. This notion of ‘crises of charismatic authority’ has in many ways become a central, recurring theme in the author's analysis of these incidents. While accepting that such crises were typically not sufficient in themselves to have precipitated each of the dramatic denouements the author has examined, he has come to the conclusion that they did play a major role in each; such crises played a much more significant role than that played by external opposition in almost all of the cases the author examined (the case of the Branch Davidians being perhaps the exception that proves the rule. In this article, the author discusses what he means by crises of charismatic authority (an important task in itself due to the diverse understandings of ‘charisma’ found within the literature and presents a comparative analysis of some of the ways in which these crises can occur.

A CRISE DA IGREJA CATÓLICA: ALGUNS DADOS EMPÍRICOS E PERSPECTIVAS TEOLÓGICAS

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Joaquín Silva Soler

2013-01-01

Full Text Available O artigo analisa o resultado de pesquisa realizada, em 2012, pelo Centro de Políticas Públicas e o Instituto de Sociologia da Pontifícia Universidade Católica de Chile sobre a Igreja Católica nesse país. Os dados do estudo mostram uma situação de crise do catolicismo chileno. Tal crise tem causas diversas, intra e extra eclesial: mudança cultural profunda, crise de identidade missionária da Igreja, crise de fé, crise de confiança, crise que convida a uma nova evangelização. A constatação dos limites da presença e influência da Igreja católica na era pós-moderna constitui desafio oportuno para se afirmar a importância da proposta do Cristianismo como caminho para a felicidade pessoal e para ajudar a construir uma sociedade onde reinem a justiça, a paz e a liberdade. O autêntico cristão vive a fé comprometido com a realidade integral do ser humano e da sociedade. Tal empenho se vincula ao sentido escatológico da fé e da vida eclesial. Os cristãos são chamados a manter viva a esperança, procurando superar a crise através da vivência da conversão e do perdão no seguimento de Jesus Cristo, sempre atentos aos sinais dos tempos. ABSTRACT: The article looks at the result of research carried out in 2012, by the Center for Public Policy and the Institute of Sociology of the Catholic University of Chile on the Catholic Church in that country. The data of the study show a crisis situation of Chilean Catholicism. This crisis has many causes, intra and extra ecclesial: a profound cultural change, a crisis of the Church’s missionary identity, a crisis of confidence, a crisis that calls for a new evangelization. The finding of the limits of the presence and influence of the Catholic Church in the post-modern era is a timely challenge to assert the importance of the proposal of Christianity as a path to personal happiness and to help build a society where justice, peace and freedom reign. The authentic Christian lives the

The Framing of Humanitarian Crises in the Spanish Media: An Inductive Approach

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Alberto Ardèvol-Abreu

2016-01-01

Full Text Available The media are important actors in humanitarian crisis management and resolution, both in the countries facing the crises and in the rest of the world. Based on an inductive approach to a news sample from four Spanish newspapers, this study analyses the news frames used in the coverage of countries facing humanitarian crises. Results show that, with certain differences between countries, the Spanish press frames these countries as being theatres of war and violence, Islamic terrorism, and crime. From a theoretical perspective, results also suggest that news frames should not be classified either as "generic" or "specific", but that they should instead be placed on a continuous scale ranging from "generic" through to "specific".

BRASIL EM CRISE E O EMPREGO FORMAL NO SUDESTE

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Ralfo Matos

2017-03-01

Full Text Available O presente estudo investiga a evolução do emprego formal entre 2005 e 2015 no conjunto de municípios que compõe a região Sudeste, espaço que responde por mais de 50% do emprego e do PIB do Brasil. A análise combinada dos dados disponíveis no CAGED e na RAIS evidencia o encolhimento do mercado formal de trabalho em 2015, e de forma mais expressiva nos municípios de maior porte demográfico. Entretanto, a despeito da intensificação da crise econômica a partir de 2013, no período 2013-2015, centenas de outros municípios tradicionalmente mais frágeis economicamente não vivenciaram a severidade do impacto da crise no emprego, muitos deles localizados nas áreas setentrionais da região, as que se assemelham com a região Nordeste do Brasil, espaços nos quais foram maiores os impactos das ações das políticas sociais dos últimos governos.

Comparing emerging and mature markets during times of crises: A non-extensive statistical approach

Science.gov (United States)

Namaki, A.; Koohi Lai, Z.; Jafari, G. R.; Raei, R.; Tehrani, R.

2013-07-01

One of the important issues in finance and economics for both scholars and practitioners is to describe the behavior of markets, especially during times of crises. In this paper, we analyze the behavior of some mature and emerging markets with a Tsallis entropy framework that is a non-extensive statistical approach based on non-linear dynamics. During the past decade, this technique has been successfully applied to a considerable number of complex systems such as stock markets in order to describe the non-Gaussian behavior of these systems. In this approach, there is a parameter q, which is a measure of deviation from Gaussianity, that has proved to be a good index for detecting crises. We investigate the behavior of this parameter in different time scales for the market indices. It could be seen that the specified pattern for q differs for mature markets with regard to emerging markets. The findings show the robustness of the stated approach in order to follow the market conditions over time. It is obvious that, in times of crises, q is much greater than in other times. In addition, the response of emerging markets to global events is delayed compared to that of mature markets, and tends to a Gaussian profile on increasing the scale. This approach could be very useful in application to risk and portfolio management in order to detect crises by following the parameter q in different time scales.

A crise financeira mundial, o estado e a democracia econômica

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Gabriel Real Ferrer

2010-07-01

Full Text Available Os problemas vividos na atualidade, principalmente a grave situação financeira internacional, significam sinal evidente de insuficiência do modelo teórico moderno. Talvez sustentem a própria crise do Estado Constitucional Moderno. Alguns exemplos recentes parecem comprovar tal crise: o complexo de indústrias mundiais de alimentos que arrasa sementes tradicionais acabou por criar uma situação de desequilíbrio alimentar no planeta. Além disso, fatos como  a comercialização mundial do petróleo, o monopólio da comunicação e a realidade virtual manipulável demonstram que a internalização do Poder Público da modernidade provavelmente cederá espaço à transnacionalização desse mesmo Poder Público. Repensar, pois, a Democracia neste momento é fundamental, principalmente em sua vertente transnacional. Todo o mundo “acordado” e afetado pela globalização, faz-se cada vez mais certo que o único poder legítimo é o poder com investidura decidida pela maioria, que se constitui a partir de instrumentos democráticos efetivos. Palavras-chave: Democracia. Transnacionalidade. Estado Constitucional Moderno. Estado Transnacional. Crise Financeira.

Interprofessional intensive care unit team interactions and medical crises: a qualitative study.

Science.gov (United States)

Piquette, Dominique; Reeves, Scott; Leblanc, Vicki R

2009-05-01

Research has suggested that interprofessional collaboration could improve patient outcomes in the intensive care unit (ICU). Maintaining optimal interprofessional interactions in a setting where unpredictable medical crises occur periodically is however challenging. Our study aimed to investigate the perceptions of ICU health care professionals regarding how acute medical crises affect their team interactions. We conducted 25 semi-structured interviews of ICU nurses, staff physicians, and respiratory therapists. All interviews were audio-taped and transcribed, and the analysis was undertaken using an inductive thematic approach. Our data indicated that the nature of interprofessional interactions changed as teams passed through three key temporal periods around medical crises. During the "pre-crisis period", interactions were based on the mutual respect of each other's expertise. During the "crisis period", hierarchical interactions were expected and a certain lack of civility was tolerated. During the "post-crisis period", divergent perceptions emerged amongst health professionals. Post-crisis team dispersion left the nurses with questions and emotions not expressed by other team members. Nurses believed that systematic interprofessional feedback sessions held immediately after a crisis could address some of their needs. Further research is needed to establish the possible benefits of strategies addressing ICU health care professionals' specific needs for interprofessional feedback after a medical crisis.

Reducing the Potential for Future Financial Crises: A Framework for Macro-Prudential Policy in Canada

OpenAIRE

Paul Jenkins; Gordon Thiessen

2012-01-01

Canada needs a policy framework and new governance structure beyond what is in place to reduce the potential for future financial crises. The authors make the case for establishing a formal committee with a mandate to identify potential systemic risks and to act promptly before they materialize. While Canada's system of regulating and supervising financial institutions might hold up as a model of good performance, changes can and should be made, say Jenkins and Thiessen. Future crises undoubt...

A half-baked solution : Drivers of water crises in Mexico

NARCIS (Netherlands)

Madrigal, Jonatan Godinez; van der Zaag, P.; Van Cauwenbergh, Nora

2018-01-01

Mexico is considered a regional economic and political powerhouse because of the size of its economy, and a large population in constant growth. However, this same growth accompanied by management and governance failures are causing several water crises across the country. The paper aims at

EARNINGS MANAGEMENT AND ECONOMIC CRISES IN THE BRAZILIAN CAPITAL MARKET

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Aldy Fernandes da Silva

2014-05-01

Full Text Available The 2008 economic crisis challenged accounting, either demanding recognition and measurement criteria well adjusted to this scenario or even questioning its ability to inform appropriately entities’ financial situation before the crisis occurred. So, our purpose was to verify if during economic crises listed companies in the Brazilian capital market tended to adopt earnings management (EM practices. Our sample consisted in 3,772 firm-years observations, in 13 years – 1997 to 2009. We developed regression models considering discretionary accruals as EM proxy (dependent variable, crisis as a macroeconomic factor (dummy variable of interest, ROA, market-to-book, size, leverage, foreign direct investment (FDI and sector as control variables. Different for previous EM studies two approaches were used in data panel regression models and multiple crises were observed simultaneously. Statistics tests revealed a significant relation between economic crisis and EM practices concerning listed companies in Brazil in both approaches used.

Finite-time singularities in the dynamics of Mexican financial crises

Science.gov (United States)

Alvarez-Ramirez, Jose; Ibarra-Valdez, Carlos

2004-01-01

Historically, symptoms of Mexican financial crises have been strongly reflected in the dynamics of the Mexican peso to the dollar exchange currency market. Specifically, in the Mexican financial crises during 1990's, the peso suffered significant depreciation processes, which has important impacts in the macro- and micro-economical environment. In this paper, it is shown that the peso depreciation growth was greater than an exponential and that these growth rates are compatible with a spontaneous singularity occurring at a critical time, which signals an abrupt transition to new dynamical conditions. As in the major 1990's financial crisis in 1994-1995, some control actions (e.g., increasing the USA dollar supply) are commonly taken to decelerate the degree of abruptness of peso depreciation. Implications of these control actions on the crisis dynamics are discussed. Interestingly, by means of a simple model, it is demonstrated that the time at which the control actions begin to apply is critical to moderate the adverse effects of the financial crisis.

La crise du vivre-ensemble

DEFF Research Database (Denmark)

Schultz, Nils Voisin

2014-01-01

Cet article examine les caractères idéologique et affectif de deux essais écrits respectivement par Alain Finkielkraut et Richard Millet sur la crise actuelle du vivre-ensemble en France. Les deux penseurs critiquent la société multiculturelle, mais alors que pour Finkielkraut cette société est une...... chance pour la France à condition que le dialogue interculturel soit renforcé et que l’idée d’une culture française y garde sa place, elle reste pour Millet une impossibilité. L’enjeu de l’analyse est de dévoiler la capacité des discours à générer par l’affectivité une peur capable d’intensifier l’argumentation...

Europe's vulnerability to energy crises

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-01-15

The growing dependency of Europe as a whole on energy imports and anticipated further increases in energy prices reinforce the concerns about meeting the energy demand in the future. The objective of the Study is to identify the threats leading to potential energy crises and suggest solutions for facing, in an appropriate way, the related key challenges. In addition, the Study intends to develop a number of indicators effective enough to assess the level of different types of vulnerability, as well the overall vulnerability of a country or region, including threats to physical disruption, higher energy prices etc. The use of vulnerability indicators is highly recommended for all WEC-European countries, as well as to policy makers and market players.

Energy security in the post-Cold War era: Identifying future courses for crises

Energy Technology Data Exchange (ETDEWEB)

Freund, M.T.; Wise, J.A.; Ulibarri, C.A.; Shaw, B.R.; Seely, H.E.; Roop, J.M.

1994-11-01

This paper addresses US energy security in the post-Cold War era for a conference on energy security jointly sponsored by the Department of Energy and the National Defense University. It examines the evolving nature of energy security based on analysis of past crisis-inducing events and-discusses potentially important geopolitical, environmental, regulatory, and economic developments during the next twenty-five years. The paper steps beyond the traditional economic focus of energy security issues to examine the interplay between fundamental economic and technical drivers on the one hand, and political, environmental, and perceptual phenomena, on the other hand, that can combine to create crises where none were expected. The paper expands on the premise that the recent demise of the Soviet Union and other changing world conditions have created a new set of energy dynamics, and that it is imperative that the United States revise its energy security perspective accordingly. It proceeds by reviewing key factors that comprise the concepts of ``energy security`` and ``energy crisis`` and how they may fit into the new world energy security equation. The study also presents a series of crisis scenarios that could develop during the next twenty-five years, paying particular attention to mechanisms and linked crisis causes and responses. It concludes with a discussion of factors that may serve to warn analysts and decision makers of impending future crises conditions. The crisis scenarios contained in this report should be viewed only as a representative sample of the types of situations that could occur. They serve to illustrate the variety of factors that can coalesce to produce a ``crisis.``

The Global Financial Crisis and currency crises in Latin America

NARCIS (Netherlands)

Boonman, Tjeerd M.; Jacobs, Jan P.A.M.; Kuper, Gerard H.

2012-01-01

The Global Financial Crisis (GFC) has aected many regions including Latin America. This paper focuses on currency crises in Argentina, Brazil and Mexico. We estimate an Early Warning System, consisting of a dynamic factor model and an ordered logit model, with monthly data for 1990-2007. Ex ante

De rol van sociale media bij rampen en (mini)crises

NARCIS (Netherlands)

Jan Eberg; Menno van Duin; Vina Wijkhuijs

2016-01-01

Full text beschikbaar met HU-account. Sinds de opkomst van sociale media spelen de toepassing en het bereik ervan in toenemende mate een rol, ook bij rampen en crises. De vraag rijst dan hoe daar in de crisiscommunicatie en het crisismanagement effectief mee om te gaan. Uit literatuuronderzoek en

A Retrospective Study of Long Acting Risperidone Use to Support Treatment Adherence in Youth with Conduct Disorder.

Science.gov (United States)

Demirkaya, Sevcan Karakoç; Aksu, Hatice; Özgür, Börte Gürbüz

2017-11-30

Risperidone has been widely used to control aggression and conduct disorder (CD) in youth; however, treatment compliance is a major problem in CD. Our aim is to evaluate the effectiveness and tolerability of long-acting risperidone (LAR) in treating nonadherent cases. The medical records of children and adolescents who had CD and were nonadherent to conventional drugs and psychosocial interventions (and therefore taking LAR) were reviewed. Informed consent on offlabel use of LAR was obtained from the parents. Clinical Global Impression (CGI) Severity (CGI-S) and CGI-Improvement scales were used and baseline and end points were compared. The study comprised 14 children and adolescents (5 girls, 9 boys). All had comorbid disorders: substance use disorder (n=8), attention deficit hyperactivity disorder (n=6), and major depression (n=2). Mean duration of LAR use was 3.1 months (1.5-8 months). We observed significant improvements in the baseline and endpoint CGI-S scores for CD in all but one patient (Z=-3.198; p ＜0.001). Only mild adverse effects were observed: weight gain (n=2), sedation (n=1), leg cramps (n=1), and increased appetite with no weight gain (n=1). LAR is effective and tolerable for patients with CD who can't be medicated with oral preparations due to nonadherence to treatment. Even short-term LAR use is effective to get compliance. As CD predicts numerous problems in adulthood, appropriate treatment is crucial. To our knowledge, this is the first study on LAR use in youth with CD. The use of LAR deserves careful consideration and further controlled studies are needed to confirm our findings.

Crises de Segurança do Alimento e a Demanda por Carnes no Brasil

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Moisés de Andrade Resende Filho

Full Text Available Resumo: Investiga-se se crises de segurança do alimento deslocam para baixo as demandas por carne bovina, suína e de frango no Brasil. Constroem-se três séries de índices de crises de segurança do alimento, um para cada tipo de carne, somando-se o total de notícias na Folha de São Paulo que atenderam a critérios predefinidos de busca. Utilizam-se estas três séries, os preços das carnes e de um bem composto e o gasto per capita com consumo como variáveis explicativas em seis especificações alternativas de um sistema de quatro equações de demanda. Seleciona-se a melhor especificação do modelo por meio de testes ajustados de razão de verossimilhança. Testes com o modelo selecionado não rejeitam a hipótese de que as demandas não são afetadas por crises de segurança do alimento. Conclui-se que se deslocamentos da demanda para baixo em reação a crises de segurança do alimento criam incentivos para que as empresas adotem medidas para produzir um alimento mais seguro, tais incentivos não existem nos setores de carnes no Brasil. Assim, reforça-se a importância e necessidade de um sistema público ativo para regulamentar e estabelecer padrões de segurança da carne no Brasil.

Cultural Erosion and the Crises of Development in Nigeria | Yakubu ...

African Journals Online (AJOL)

The paper explores the dynamics of cultural change and the erosion of cultural heritage vis-à-vis the consequent developmental crises that have enveloped the Nigerian nation for several decades. It is divided into five sections. In the introductory section, the concept of culture is defined, described, and contextualized within ...

Ethnic and religious crises in Nigeria: A specific analysis upon ...

African Journals Online (AJOL)

hither and thither by recurrent crises of regional or state illegitimacy, often impairing efforts at ... at the notion of Identity and how it explains the crisis of development and ... network of politically silent identities, coupled with a history of protracted ...... Understanding the emerging trends of terrorism in Nigeria: A case study.

Depositor Discipline and Bank Risk-Taking Behavior: Evidence From the South-East Asian Financial Crises

OpenAIRE

M. Kabir Hassan; M. Ershad Hussain

2006-01-01

This paper examines whether the risk-taking behavior of commercial banks in five countries of South-East Asia changed after the Asian Crises of 1997. The paper utilizes the framework created by Gruben et al (1997, 1998, and 2003). It also examines the connection between the risk-taking behavior and depositor discipline of these banks after the Asian Crises of 1997. Based on bank level data from the Bank Scope, 2005 CD, he paper presents evidence that the state of depositor discipline is very ...

Employee Communication during Crises: The Effects of Stress on Information Processing.

Science.gov (United States)

Pincus, J. David; Acharya, Lalit

Based on multidisciplinary research findings, this report proposes an information processing model of employees' response to highly stressful information environments arising during organizational crises. The introduction stresses the importance of management's handling crisis communication with employees skillfully. The second section points out…

The benefit of issue management: anticipating crises in the digital age

NARCIS (Netherlands)

Strauβ, N.; Jonkman, J.

2017-01-01

Purpose The purpose of this paper is to find out how issue management and media monitoring is exercised in the digital age to anticipate crises. More specifically, it was investigated how these practices differ across communication professionals, organizations, and sectors in the Netherlands.

Supporting Students with Disabilities during School Crises: A Teacher's Guide

Science.gov (United States)

Clarke, Laura S.; Embury, Dusty Columbia; Jones, Ruth E.; Yssel, Nina

2014-01-01

Most schools have crisis plans to support student safety, but few plans address the complex needs of students with disabilities. School supports should include analysis of school plans and student strengths and needs to ensure that students with disabilities have the best opportunity to be safe in school crises. Recommendations include developing…

Crise da água na região metropolitana de São Paulo – 2013/2015

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Pedro Roberto Jacobi

2015-12-01

Full Text Available A diminuição dos índices pluviométricos na região sudeste do Brasil apresentavam um cenário previsível de escassez hídrica no ano de 2015. Diante da negação da possível crise, a gestão hídrica restou prejudicada. A situação crítica e a morosidade na proposição de medidas efetivas para minimizar a crise fazem da Região Metropolitana de São Paulo uma área crítica em relação à qualidade e quantidade de água. Da observação dessa nova condição, o presente artigo, além de contextualizar a crise, se propõe a apresentar propostas para gestão dos recursos hídricos no estado.

Liquidity, banking and financial crises / B. de Waal

OpenAIRE

De Waal, B

2013-01-01

Some financial experts have blamed deficiencies in Basel II capital regulation for the exacerbation of financial crises in 2007 to 2012. In response to this, new proposals in the form of Basel III attempt to raise the quality, consistency and transparency of the regulatory capital base in order to enhance the risk coverage of Basel II via appropriate ratios. In this article, the authors explore how the new Basel liquidity standards, as encapsulated by the liquid coverage ratio ...

An organisational coherence model to maintain employee contributions during organisational crises

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Hendrik J. Pelser

2016-06-01

Full Text Available Orientation: Crises that threaten an organisation’s continued existence cannot be seen in isolation when considering the perception of threats to individual job security. These threats often go hand in hand with employee panic. Research purpose: The aim of this study was to establish a model to assist organisations in managing employee emotionality and panic during times of crisis. Motivation for the study: Environmental crises threaten organisations’ existence, threatening employees’ livelihood and resulting in employee panic. Panic reduces employees’ contributions. Organisations that are successful harness employee contributions at all times. Research design, approach, and method: A modernist qualitative research methodology was adopted, which included a case study as research strategy, purposive sampling to select 12 research participants, semi-structured interviews for data gathering, focus groups for data verification, and the use of grounded theory for data analysis. Main findings: An organisation’s ability to manage employee panic depends on the relationship between the foundational elements of authentic leadership, crisis readiness, resilience practices, versatile and committed talent, strategic management, quality management, and coherence actions taken during the crisis, which include crisis leadership, ongoing visible communication, mindfulness, work flexibility, and decisions based on the greatest financial need and social support. Practical/managerial implications: The study provides a best-practice option for managing emotionality during crises for the case organisation and other organisations within the vehicle components and other manufacturing industries. Contribution/value-add: The Coherence Hexagons Model is presented as a tool to manage employee panic during crisis. Keywords: crisis management; employee emotionality; employee panic; authentic leadership; talent management

Basel III and prudent risk management in banking: Continuing the cycle of fixing past crises

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François Laurens

2012-09-01

Full Text Available Financial crises have had a significant impact on bank regulation and supervision. Reforms are often focussed on correcting past failings. Following the 2007 financial crisis, Basel III reforms have been introduced with a view to promote a more resilient banking sector and to improve the banking sector’s ability to absorb shocks arising from financial distress. A review of the Basel III reforms and the literature on the link between capital adequacy regulations and bank stability indicates that these regulations are unlikely to prevent the failure of banks resulting in systemic crises

Currency Crises and Monetary Policy in an Economy with Credit Constraints

DEFF Research Database (Denmark)

Bergman, Ulf Michael; Hassan, Shakill

This paper revisits the currency crises model of Aghion, Bacchetta and Banerjee (2000, 2001, 2004), who show that if there exist nominal price rigidities and private sector credit constraints, and the credit multiplier depends on real interest rates, then the optimal monetary policy response...

Crise et sécurité alimentaires : vers un nouvel ordre alimentaire mondial ?

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Christophe Golay

2012-04-01

Full Text Available En 2007 et 2008 a éclaté la plus importante crise alimentaire depuis 1974. La hausse du prix des denrées alimentaires sur le marché international, en particulier du blé, du riz, du soja et du maïs, a entraîné une augmentation sans précédent du nombre de personnes sous-alimentées. Malgré une diminution relative du prix des denrées alimentaires depuis l’été 2008, le nombre de personnes sous-alimentées a continué à augmenter en 2009. Cette crise alimentaire a remis la lutte contre la faim au cœur des préoccupations internationales. Depuis le mois de mars 2008, les Etats, les agences des Nations unies et une grande partie des mouvements sociaux ont pris position sur les causes de la crise et les moyens d’y remédier. Malheureusement, alors que ces acteurs tentent de coordonner leurs activités et de proposer des solutions nouvelles, ce sont souvent des recettes anciennes, visant à augmenter la production alimentaire, qui sont mises en avant. Les propositions faites sont souvent contradictoires et les réflexions sur les causes profondes de la faim et de la crise alimentaire – les exclusions sociales, économiques et politiques et les discriminations – ne semblent pas avoir été entendues. Le premier Objectif du Millénaire pour le développement, qui vise à réduire de moitié la proportion des personnes souffrant de sous-alimentation et vivant dans l’extrême pauvreté d’ici 2015, est devenu clairement inatteignable. Mais la crise alimentaire pourrait être à l’origine de la création d’un nouvel ordre alimentaire mondial, basé sur les trois piliers que sont l’aide alimentaire, la sécurité alimentaire et le droit à l’alimentation.

Chaos Theory as a Model for Managing Issues and Crises.

Science.gov (United States)

Murphy, Priscilla

1996-01-01

Uses chaos theory to model public relations situations in which the salient feature is volatility of public perceptions. Discusses the premises of chaos theory and applies them to issues management, the evolution of interest groups, crises, and rumors. Concludes that chaos theory is useful as an analogy to structure image problems and to raise…

Análise comparativa de risco de câmbio e das taxas de juros na crise cambial de 1999

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Hélio Rosseti Júnior

2009-09-01

Full Text Available É nos momentos de crise que os novos paradigmas surgem em substituição dos antigos, ocorrendo, assim, o renovar das formas de se entender os mecanismos de funcionamento da sociedade, as relações de produção e os modelos de consumo. A crise cambial brasileira de 1999 trouxe dificuldades para a população e para o país, exigindo mudanças de postura do governo e dos organismos da sociedade. A crise provocou uma retração de produção do Brasil, uma elevação dos juros e, por conseguinte, do endividamento do país. Uma crise que teve como centro a taxa de câmbio acabou tendo seus maiores desdobramentos nas taxas de juros, tanto do governo como no mercado. Este trabalho de pesquisa procura analisar o comportamento dos juros efetivamente praticados no mundo financeiro nacional, a partir da flutuação das taxas de câmbio, no ano da crise. Para tanto, são estudados os números diários e mensais de relatórios do Banco Central e os dados da evolução dessas taxas.

It's meaning making stupid! Succes of public leadership during flash crises

NARCIS (Netherlands)

Helsloot, I.; Groenendaal, J.

2017-01-01

Boin et al. (International Review of Public Administration, 18, 2013, 79) and others propose that public crisis leadership consists of several core tasks, among which crisis decision-making and meaning making stand out in “flash crises.” We however argue that successful leadership during a sudden

It's meaning making, stupid! Success of public leadership during flash crises

NARCIS (Netherlands)

Helsloot, I.; Groenendaal, J.

2017-01-01

Boin et al. (International Review of Public Administration, 18, 2013, 79) and others propose that public crisis leadership consists of several core tasks, among which crisis decision-making and meaning making stand out in “flash crises.” We however argue that successful leadership during a sudden

Detecting Corporate Social Media Crises on Facebook Using Social Set Analysis

DEFF Research Database (Denmark)

Mukkamala, Raghava Rao; Iskou Sørensen, Jannie; Hussain, Abid

2015-01-01

social media crises using social set analysis-an approach to computational social based on associational sociology and set theory. Based on a conceptual and formal model of social data, we conduct social set analysis of the facebook wall data of four diferent Danish companies. Findings show...

REFLETINDO SOBRE AS ESPECIFICIDADES DA GEOGRAFIA NA CRISE DA MODERNIDADE

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Patrício A. S. Carneiro Carneiro

2010-08-01

Full Text Available O presente artigo discute a evolução da ciência moderna, bem como a crise desse paradigma dominante e seus efeitos sobre a geografia. Destaca ainda a necessidade da construção de um novo pensamento científico para além das fronteiras disciplinares e do método absoluto.

Non-criticality of interaction network over system's crises: A percolation analysis.

Science.gov (United States)

Shirazi, Amir Hossein; Saberi, Abbas Ali; Hosseiny, Ali; Amirzadeh, Ehsan; Toranj Simin, Pourya

2017-11-20

Extraction of interaction networks from multi-variate time-series is one of the topics of broad interest in complex systems. Although this method has a wide range of applications, most of the previous analyses have focused on the pairwise relations. Here we establish the potential of such a method to elicit aggregated behavior of the system by making a connection with the concepts from percolation theory. We study the dynamical interaction networks of a financial market extracted from the correlation network of indices, and build a weighted network. In correspondence with the percolation model, we find that away from financial crises the interaction network behaves like a critical random network of Erdős-Rényi, while close to a financial crisis, our model deviates from the critical random network and behaves differently at different size scales. We perform further analysis to clarify that our observation is not a simple consequence of the growth in correlations over the crises.

Da violência ao vínculo: construindo novos sentidos para a atenção à crise

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Janaína Quinzen Willrich

2014-01-01

Full Text Available Este estudo objetiva conhecer os sentidos presentes nas práticas discursivas de profissionais de Centros de Atenção Psicossocial produzidos pelas novas formas de lidar e se relacionar com o sujeito em crise psíquica grave. Trata-se de uma pesquisa qualitativa, embasada na perspectiva teórica do Construcionismo Social. Analisou-se 27 entrevistas de profissionais a partir da identificação dos repertórios interpretativos e da construção dos Mapas de Associação de Ideias. Os dados foram organizados nos temas: Dificuldades da contenção no serviço; Sentidos construídos em torno dessa prática; Posicionamentos dos profissionais em relação a essa prática; Participação da Polícia Militar no cuidado da crise; Sentido de responsabilidade da equipe de enfermagem em cuidar da crise. Demonstra-se a necessidade de discussão e construção de práticas de atenção à crise que sejam mais coletivas e embasadas em relações de contrato que respeitem a singularidade e subjetividade dos sujeitos.

Crises and Opportunities: A Manifesto for Change

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Ian Johnson

2012-10-01

Full Text Available Piecemeal fragmented strategies cannot address the pressing challenges facing humanity today. Economic theory has to be radically reinvented to squarely face the reality of rising unemployment, widening inequalities, growing ecological threats, frustrated social aspirations and unmet human needs. Monetary and fiscal policies are too crude and insufficient to steer the essential change of course required to address multidimensional demographic, ecological, economic, political and social crises. New values are needed to guide policy formulation and new institutions are needed to support peaceful social evolution and inclusive, equitable development in an increasingly globalized and interconnected world.

Speculative attacks, openness and crises

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Aloisio Araujo

2012-06-01

Full Text Available We extended the Cole and Kehoe model (1996 by adding trade and debt denominated in national currency. We then evaluated some external debt defaults and steep national currency devaluations occurred during last decades. Although default is unlikely, steep devaluation has been repeatedly triggered during financial distresses. It helps to overcome financial crisis as it improves trade balance and reduces national debt level. On the other hand, expected devaluation hurts welfare through both higher national debt cost and reductions in the investment level. We modeled such trade-offs and showed that trade openness, by and large, improves the expected welfare as it allows for a better devaluation-response technology. We ran model simulations based on past 48 crises occurred in 32 middle-income countries, reasonably fitting devaluation and default responses observed as from 1971.

The Influence of Media Coverage of Religious Crises in Nigeria: A ...

African Journals Online (AJOL)

The Influence of Media Coverage of Religious Crises in Nigeria: A Case Study of the Mohammed Cartoon Riots. ... (http://www.bbc.co.uk/news ). It also explores peoples opinion ... public for the benefit of the media institutions,(both government and privately owned media houses), journalists, the government and individuals.

Towards a European Division of Labour : Do Europe’s Crises Highlight Structural Challenges to Sustainable Economic Growth in the Eurozone?

NARCIS (Netherlands)

Scholten, D.J.; Scholten, M.

2014-01-01

The financial and economic crises of the last few years in many Southern Eurozone countries are generally studied individually, without reference to other such crises in the region. In this note, we argue that they may also be approached as symptoms of an underlying structural challenge facing the

Perspectives on Information and Communications Technology (ICT) for Civil-Military Coordination in Crises

National Research Council Canada - National Science Library

Christman, Gerard; Kramer, Franklin; Starr, Stuart; Wentz, Larry

2006-01-01

...), stabilization and reconstruction (S&R), and complex emergencies. Although these types of crises can differ in their causes and specific impacts, there are significant similarities in the information and communications technology (ICT...

Facing the Crises

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Moira Baker

2014-12-01

Full Text Available Timely, provocative, and theoretically sophisticated, the essays comprising In the Face of Crises: Anglophone Literature in the Postmodern World situate their work amid several critical global concerns: the devastation wreaked by global capitalism following the worldwide financial crash, the financial sector’s totalizing grip upon the world economy, the challenge to traditional definitions of “human nature” and identity posed by technologies of the body and of warfare, the quest of indigenous communities for healing from the continuing traumatic effects of colonization, and the increasing corporatization of the academy as an apparatus of the neo-liberal state – to specify only a few. Edited by Professors Ljubica Matek and Jasna Poljak Rehlicki, these essays deploy a broad range of contemporary theories, representing recent developments in cultural studies, the new economic criticism, postcolonial film studies, feminism and gender studies, and the new historicism. The eleven essays selected by Matek and Rehlicki offer convincing support for their claim that humanistic research delving into Anglophone literature, far from being a “non-profitable” pursuit in an increasingly technologized society, affords clarifying insights into contemporary “economic, cultural, and social processes in the globalizing and globalized culture of the West” (ix.

CHEAP MONEY POLICY AND ITS ROLE IN TRIGGERING FINANCIAL CRISES

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Dorel Dumitru CHIRITESCU

2010-06-01

Full Text Available Nothing is more natural inside the evolution of a living system than the crisis itself, the only thing that distinguishes systems from each other is represented by how crises are solved and future developments. The biggest mistake would be to think that there are companies that can develop linearly. Arbitrary, indeterminacy they are well outlined in any development.

Risks and crises for healthcare providers: the impact of cloud computing.

Science.gov (United States)

Glasberg, Ronald; Hartmann, Michael; Draheim, Michael; Tamm, Gerrit; Hessel, Franz

2014-01-01

We analyze risks and crises for healthcare providers and discuss the impact of cloud computing in such scenarios. The analysis is conducted in a holistic way, taking into account organizational and human aspects, clinical, IT-related, and utilities-related risks as well as incorporating the view of the overall risk management.

Risks and Crises for Healthcare Providers: The Impact of Cloud Computing

OpenAIRE

Glasberg, Ronald; Hartmann, Michael; Draheim, Michael; Tamm, Gerrit; Hessel, Franz

2014-01-01

We analyze risks and crises for healthcare providers and discuss the impact of cloud computing in such scenarios. The analysis is conducted in a holistic way, taking into account organizational and human aspects, clinical, IT-related, and utilities-related risks as well as incorporating the view of the overall risk management.

Os portugueses no discurso mediático europeu: as notícias sobre a crise financeira

OpenAIRE

Szeremeta, Irina Veríssimo; Aires, Luísa

2015-01-01

O discurso dos media tem uma grande importância na construção da imagem do Outro e, por consequência, influencia as relações interculturais. Neste estudo, procurou-se analisar o discurso de cinco jornais europeus para caraterizar Portugal na crise financeira de 2011. Para a consecução deste objetivo, foram analisados 25 artigos sobre a crise portuguesa, publicados em 5 jornais de diferentes países europeus. Nas notícias estudadas, os Portugueses são associados a atributos pouco valorizados na...

Investimentos estrangeiros em carteiras de ações, crises internacionais e Ibovespa

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Antônio André Cunha Callado

2007-03-01

Full Text Available Este trabalho analisou a relação entre o comportamento do mercado acionário brasileiro, representado pelo Ibovespa, e os fluxos de capitais estrangeiros direcionados para investimentos em carteira de ações, no período posterior à implantação do Plano Real. Ao longo desse período, foram observadas diversas crises financeiras no âmbito internacional que provocaram instabilidade e volatilidade nos fluxos de capitais estrangeiros. Este trabalho considera as influências sistemáticas dessas instabilidades sobre o Ibovespa, especialmente pela capitalização relativamente pequena do mercado brasileiro de ações. A hipótese de mercado eficiente supõe que os preços das ações, e com isso o Ibovespa, seguem um caminho aleatório e não devem estar sujeitos a influências sistemáticas de outros fatores. A hipótese geral do trabalho é que os fluxos de capitais estrangeiros direcionados para o mercado acionário brasileiro influenciam significativamente o Ibovespa. A hipótese especifica que crises internacionais e nacionais influenciam negativamente os fluxos de capitais estrangeiros nesse segmento e com isso o Ibovespa. A justificação para este trabalho é de que essas influências sistemáticas de crises sobre o Ibovespa são um fator sistemático que limita a hipótese de mercado acionário brasileiro eficiente. Foi realizada uma análise empírica com diferentes modelos mostrando que há evidências de influência sistemática dos fluxos de capital estrangeiro em carteira de ações sobre o Ibovespa. Esses achados limitam, de certa forma, a adequação da hipótese de mercado eficiente para o mercado brasileiro de ações. Essa influência sistemática dos fluxos de capital estrangeiro sobre o Ibovespa pode ser um fenômeno restrito no período analisado, refletindo a alta volatilidade dos fluxos de capitais estrangeiros por causa de crises externas e internas.

Markets during world oil supply crises: an analysis of industry, consumer, and governmental response

Energy Technology Data Exchange (ETDEWEB)

Erfle, Stephen; Pound, John; Kalt, Joseph

1981-04-01

An analysis of the response of American markets to supply crises in world oil markets is presented. It addresses four main issues: the efficiency of the operation of American oil markets during oil supply crises; the problems of both economic efficiency and social equity which arise during the American adaptation process; the propriety of the Federal government's past policy responses to these problems; and the relationship between perceptions of the problems caused by world oil crises and the real economic natures of these problems. Specifically, Chapter 1 presents a theoretical discussion of the effects of a world supply disruption on the price level and supply availability of the world market oil to any consuming country including the US Chapter 2 provides a theoretical and empirical analysis of the efficiency of the adaptations of US oil product markets to higher world oil prices. Chapter 3 examines the responses of various groups of US oil firms to the alterations observed in world markets, while Chapter 4 presents a theoretical explanation for the price-lagging behavior exhibited by firms in the US oil industry. Chapter 5 addresses the nature of both real and imagined oil market problems in the US during periods of world oil market transition. (MCW)

Fundo público e políticas sociais na crise do capitalismo Public fund and social policies in the crisis of capitalism

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Evilasio Salvador

2010-12-01

Full Text Available A característica comum a todas as crises financeiras dos últimos trinta anos é o comparecimento do fundo público para socorrer instituições financeiras falidas durante as crises bancárias, à custa dos impostos pagos pelos cidadãos. Com a financeirização da riqueza, os mercados financeiros passam a disputar cada vez mais recursos do fundo público, impedindo a expansão dos direitos sociais. Este artigo tem por objetivo discutir a crise do capital a partir do papel exercido pelo fundo público e seus rebatimentos no financiamento da seguridade social no Brasil.The characteristic that has been common to all financial crises in the last 30 years is the appearance of the public fund to bail out bankrupt financial institutions during the banking crises, at the expense of taxes paid by the citizens. Financing wealth, financial markets dispute resources from the public fund more and more, which impedes the expansion of social rights. This article aims to discuss the crisis of the capital from the role played by public funds and their impact on the financing of social security in Brazil.

Efeito da crise de 2007/2008 na transmissão internacional de volatilidade no mercado de capitais brasileiro

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Marcelo Brutti Righi

Full Text Available Com a crescente globalização, os mercados financeiros do mundo todo passaram a apresentar maior integração. Tal relacionamento entre mercados possui como implicação um termo que vem atraindo a atenção de profissionais e acadêmicos, a transmissão de volatilidade. Dessa forma, o presente trabalho tem como escopo analisar a transmissão internacional de volatilidade no mercado brasileiro. Para tanto, é utilizado um modelo Garch multivariado com parametrização BEKK. Com base nesse modelo, são estimados os relacionamentos bivariados entre o mercado brasileiro, representado pelo índice Ibovespa, e os mercados americano, argentino, mexicano e chinês, utilizando-se de índices representativos de 4 de janeiro de 2000 até 31 de março de 2010, totalizando 2667 cotações. A amostra foi dividida em três partes, representando os períodos anteriores, durante e posteriores à crise do subprime de 2007/2008. Os resultados obtidos permitem concluir que, durante a crise de 2008, de forma geral, houve mudança na direção da transmissão de volatilidade entre o mercado brasileiro e os demais estudados, de forma ao Brasil passar a exercer maior influência na volatilidade condicional desses, por ter sofrido menores consequências com a crise financeira. Além disso, após o período de turbulência causado pela crise de 2008, o relacionamento da volatilidade entre o mercado brasileiro com os demais passou a ser menos assimétrico do que no período anterior a crise.

Past Adolescence, into and across Adulthood: Career Crises and Major Decisions

Science.gov (United States)

Bakshi, Anuradha J.

2011-01-01

Career-related crises and major decisions, support for these, and job satisfaction were surveyed in 124 varied individuals from Mumbai, India. All participants were in the post-career-entry stage and engaged in paid work; they differed with regard to age (range 18-75 years), sex, marital status, religion, education, occupation, income, and…

Signos, significados e práticas de manejo da crise em Centros de Atenção Psicossocial

Directory of Open Access Journals (Sweden)

Mônica Lima

Full Text Available Neste artigo discutimos significados atribuídos pelos familiares e profissionais às situações de crise em saúde mental e suas relações com as tecnologias empregadas no cuidado de usuários de CAPS na Bahia e em Sergipe. Inspiramo-nos no modelo teórico-metodológico de Sistema de signos, significados e práticas, utilizando técnicas qualitativas de pesquisa. Organizamos os dados em duas categorias: os signos e significados de crise; as estratégias e as dificuldades no seu cuidado. Observamos que não há muita diferença entre as concepções de profissionais e familiares acerca da crise e que os significados negativos suplantam os positivos, evocando os conceitos de sujeição à doença, incapacidade de interação social racional e periculosidade do doente. Dois aspectos são importantes no manejo da crise: sua imprevisibilidade e sua inscrição na história da pessoa. Para contornar as dificuldades nesse manejo, é necessário investir nas tecnologias leve-duras e leves, pautadas em vínculos duradouros e na intensificação de cuidados.

Signos, significados e práticas de manejo da crise em Centros de Atenção Psicossocial

Directory of Open Access Journals (Sweden)

Mônica Lima

2012-06-01

Full Text Available Neste artigo discutimos significados atribuídos pelos familiares e profissionais às situações de crise em saúde mental e suas relações com as tecnologias empregadas no cuidado de usuários de CAPS na Bahia e em Sergipe. Inspiramo-nos no modelo teórico-metodológico de Sistema de signos, significados e práticas, utilizando técnicas qualitativas de pesquisa. Organizamos os dados em duas categorias: os signos e significados de crise; as estratégias e as dificuldades no seu cuidado. Observamos que não há muita diferença entre as concepções de profissionais e familiares acerca da crise e que os significados negativos suplantam os positivos, evocando os conceitos de sujeição à doença, incapacidade de interação social racional e periculosidade do doente. Dois aspectos são importantes no manejo da crise: sua imprevisibilidade e sua inscrição na história da pessoa. Para contornar as dificuldades nesse manejo, é necessário investir nas tecnologias leve-duras e leves, pautadas em vínculos duradouros e na intensificação de cuidados.

A Numeric Scorecard Assessing the Mental Health Preparedness for Large-Scale Crises at College and University Campuses: A Delphi Study

Science.gov (United States)

Burgin, Rick A.

2012-01-01

Large-scale crises continue to surprise, overwhelm, and shatter college and university campuses. While the devastation to physical plants and persons is often evident and is addressed with crisis management plans, the number of emotional casualties left in the wake of these large-scale crises may not be apparent and are often not addressed with…

Factors Influencing Company Relations with Market Stakeholders, in the Face of Crises in Company Development

Directory of Open Access Journals (Sweden)

Olszewska Barbara

2014-06-01

Full Text Available Crises in company development are a particular subset of management crises. They emerge on various stages of company development, as a result of gradual depletion of effective management solutions. Crisis situations in companies have varied impact on company stakeholders. The paper presents results of empirical studies of factors influencing company relations with market stakeholders and those that facilitate the process of restoring and maintaining any relations that suffered in the course of crises in company development. The authors’ intention was to identify such factors and evaluate their importance, in relation to various stages of company development and the associated types of crisis situations faced by companies. Empirical studies suggest that certain factors may facilitate conflict resolution in matters concerning company relations with market stakeholders, and that the impact of these factors varies depending on the phase of organizational development and the type of the associated crisis situation. It must be noted, that one of the most important factors to influence problem resolution is the perceived honesty of the exchange participants. Moreover, research suggests that opinions on the significance of organizational dependence of exchange participants in the resolution of problems in relations with market stakeholders are varied.

On Zombie Banks and Recessions after Systemic Banking Crises: Government Intervention Matters

NARCIS (Netherlands)

Homar, T.; van Wijnbergen, S.

2013-01-01

Systemic banking crises often continue into recessions with large output losses (Reinhart & Rogoff 2009a). In this paper we ask whether the way Governments intervene in the financial sector has an impact on the economy's subsequent performance. Our theoretical analysis focuses on bank incentives to

Hope in the midst of Death: Charismatic Spirituality, Healing Evangelists and the Ebola Crises in Sierra Leone

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Bangura, Joseph Bosco

2016-12-01

Full Text Available The Ebola crises that crippled West Africa from December 2013 onwards is a watershed moment in the history of those nations. The crises profoundly impacted the regions inadequate healthcare, obstructed the potential for socioeconomic development, and challenged long held traditional and religious beliefs. As Ebola began to take its toll by depleting human life, the world could not stand idly by and observe as poor post-war nations were overwhelmed by a colossal health catastrophe. By the time Ebola was contained, this obnoxious monster had taken an estimated 11,300 lives in the three worst affected countries in the region. But while medical practitioners were at the forefront of the battle, healing evangelists drawing inspiration from their understanding of Scripture, African culture and Charismatic spirituality, also provided responses that proved essential in the fight against Ebola. This article reviews the responses proffered by healing evangelists and discuss how the overall Charismatic spirituality inspired hope in the midst of the Ebola crises in Sierra Leone.

Minocycline as Adjunctive Treatment to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind Placebo-Controlled Trial.

Science.gov (United States)

Ghaleiha, Ali; Alikhani, Rosa; Kazemi, Mohammad-Reza; Mohammadi, Mohammad-Reza; Mohammadinejad, Payam; Zeinoddini, Atefeh; Hamedi, Mehdi; Shahriari, Mona; Keshavarzi, Zahra; Akhondzadeh, Shahin

2016-11-01

This is an investigation of minocycline efficacy and safety as an adjuvant to risperidone in management of children with autism. Forty-six children with diagnosis of autistic disorder, according to the Diagnostic and Statistical Manual of Mental Disorders, 4th ed., Text Revision (DSM-IV-TR) criteria and a score of ≥12 on the Aberrant Behavior Checklist-Community (ABC-C) irritability subscale, who were already drug-free for at least 6 months participated in a randomized controlled trial and underwent 10 weeks of treatment with either minocycline (50 mg twice per day) or placebo in addition to risperidone titrated up to 2 mg/day (based on bodyweight). Patients were evaluated using ABC-C at baseline and at weeks 5 and 10. General linear model repeated measures showed significant effect for time × treatment interaction on the irritability [F(2, 88) = 3.94, p = 0.02] and hyperactivity/noncompliance [F(1.50, 66.05) = 7.92, p = 0.002], but not for lethargy/social withdrawal [F(1.61, 71.02) = 0.98, p = 0.36], stereotypic behavior [F(1.34, 58.80) = 1.55, p = 0.22], and inappropriate speech subscale scores [F(1.52, 66.88) = 1.15, p = 0.31]. By week 10, 21 (91.3%) patients in the minocycline group and 15 (65.5%) patients in the placebo group achieved at least partial response (p = 0.03). Frequencies of adverse events were not significantly different between groups. Minocycline seems to be a safe and effective adjuvant in management of patients with autistic disorder. Future studies with larger sample sizes, longer follow-ups, and inflammatory cytokine measurements are warranted to confirm these findings and provide insight into minocycline mechanism of action in autistic disorder.

Homoclinic crises in a model for the CO2 laser

International Nuclear Information System (INIS)

Pando L, C.L.; Cerdeira, H.A.

1993-04-01

We show that the four-level model for the CO 2 laser with modulated losses predicts a critical exponent close to 1/2 for the characteristic times in two homoclinic crises. In the five-dimensional Poincare map corresponding to this model, a sequential horseshoe formation due to the period three unstable orbit takes place after a region of multistability. (author). 14 refs, 4 figs

Emergency Preparedness for Disasters and Crises in the Hotel Industry

OpenAIRE

Ahmad Rasmi AlBattat; Ahmad Puad Mat Som

2013-01-01

Safety and security are the most important issues to tourist while traveling and the first aspect they consider is to be protected from hazards. Emergency planning and preparedness for a crisis are the most significant components of dealing with disasters. Hospitality practitioners noticed a rising number of natural and man-made crises that harm the hospitality industry, regarding its vulnerability to crisis and intern...

Risks and Crises for Healthcare Providers: The Impact of Cloud Computing

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Ronald Glasberg

2014-01-01

Full Text Available We analyze risks and crises for healthcare providers and discuss the impact of cloud computing in such scenarios. The analysis is conducted in a holistic way, taking into account organizational and human aspects, clinical, IT-related, and utilities-related risks as well as incorporating the view of the overall risk management.

Crisis Reliability Indicators Supporting Emergency Services (CRISES): A Framework for Developing Performance Measures for Behavioral Health Crisis and Psychiatric Emergency Programs.

Science.gov (United States)

Balfour, Margaret E; Tanner, Kathleen; Jurica, Paul J; Rhoads, Richard; Carson, Chris A

2016-01-01

Crisis and emergency psychiatric services are an integral part of the healthcare system, yet there are no standardized measures for programs providing these services. We developed the Crisis Reliability Indicators Supporting Emergency Services (CRISES) framework to create measures that inform internal performance improvement initiatives and allow comparison across programs. The framework consists of two components-the CRISES domains (timely, safe, accessible, least-restrictive, effective, consumer/family centered, and partnership) and the measures supporting each domain. The CRISES framework provides a foundation for development of standardized measures for the crisis field. This will become increasingly important as pay-for-performance initiatives expand with healthcare reform.

Contingency and Political Action: The Role of Leadership in Endogenously Created Crises

Directory of Open Access Journals (Sweden)

András Körösényi

2016-06-01

Full Text Available Among the recent literature about leadership and crisis situations two main strands are to be observed: structuralist ones mainly treat political leaders as reactive agents who have relatively little room for maneuver, while constructivist ones put greater emphasis on the opportunities in interpreting crises. Our claim is that there is a third analytical possibility mainly neglected in recent literature that is even more voluntaristic than the constructivist approaches. In this scenario, there is no external shock; leaders do not only interpret, but also “invent” crises. To make our claim plausible, we build a conceptual-descriptive typology of the potential relationships between crisis situations and agency. The typology is founded on Kari Palonen’s differentiation between Machiavellian and Weberian types of contingency, but uses his originally conceptual historical argument for analytical purposes. To underpin our theoretical argument, we present short illustrative examples to all three types of crisis scenarios (the structuralist, the constructivist, and the voluntarist one.

The effect of the Taq1A variant in the dopamine D2 receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys

NARCIS (Netherlands)

Roke, Y.; Harten, P.N. van; Franke, B.; Galesloot, T.E.; Boot, A.M.; Buitelaar, J.K.

2013-01-01

OBJECTIVE: To investigate the effect of the Taq1A variant in the Dopamine D2 receptor gene (DRD2) and common functional genetic variants in the cytochrome P450 2D6 gene (CYP2D6) on prolactin levels in risperidone-treated boys with autism spectrum disorders and disruptive behavior disorders. METHODS:

The effect of the Taq1A variant in the dopamine D-2 receptor gene and common CYP2D6 alleles on prolactin levels in risperidone-treated boys

NARCIS (Netherlands)

Roke, Yvette; van Harten, Peter N.; Franke, Barbara; Galesloot, Tessel E.; Boot, Annemieke M.; Buitelaar, Jan K.

Objective To investigate the effect of the Taq1A variant in the Dopamine D2 receptor gene (DRD2) and common functional genetic variants in the cytochrome P450 2D6 gene (CYP2D6) on prolactin levels in risperidone-treated boys with autism spectrum disorders and disruptive behavior disorders.Methods

Financial integration and financial development in transition economies: What happens during financial crises?

Directory of Open Access Journals (Sweden)

Igor Masten

2011-12-01

Full Text Available

This paper provides an empirical analysis of the role of financial development and financial integration in the growth dynamics of transition countries. We focus on the role of financial integration in determining the impact of financial development on growth, distinguishing “normal times” from periods of financial crises. In addition to confirming the significant positive effect on growth exerted by financial development and financial integration, our estimates show that a higher degree of financial openness tends to reduce the contractionary effect of financial crises, by cushioning the effect on the domestic supply of credit. Consequently, the high reliance on international capital flows by transition countries does not necessarily increase their financial fragility. This implies that financial protectionism is a self-defeating policy, at least for transition countries.

Immigration et crise d'identite dans l'Univers Romanesque de Sami ...

African Journals Online (AJOL)

Immigration et crise d'identite dans l'Univers Romanesque de Sami Tchak. ... La littérature africaine du XXIème siècle a eu une grande transformation. Cela est dû au fait ... It is established that Sami Tchak takes profound interest in projecting and handling the themes of immigration and identity crisis in his novelistic world.

A crise financeira global e depois: um novo capitalismo?

Directory of Open Access Journals (Sweden)

Luiz Carlos Bresser-Pereira

2010-03-01

Full Text Available A crise financeira global de 2008 foi conseqüência do processo de financeirização, a criação maciça de riqueza financeira fictícia iniciada da década de 1980, e da hegemonia de uma ideologia reacionária, o neoliberalismo, baseada em mercados auto-regulados e eficientes. Dessa crise emergirá um novo capitalismo, embora sua natureza seja de difícil previsão. Não será financeirizado, mas serão retomadas as tendências presentes nos trinta anos dourados em direção ao capitalismo global e baseado no conhecimento, além da tendência de expansão da democracia, tornando-a mais social e participativa.The 2008 global financial crisis was a consequence of the processes of financialization, the massive creation of fictitious financial wealth which began in the 1980's, and of the hegemony of a reactionary ideology, neoliberalism, based on the belief of the self-regulating capacity and efficiency of markets. From this crisis a new capitalism will emerge, althought its chacarteristics are hard to foresee. It will not be financial, but the tendencies of the 30 "golden years" toward global and knowledge-based capitalism, and the tendency of expansion of democracy will be among them.

Measuring complexity in Brazilian economic crises.

Science.gov (United States)

Mortoza, Letícia P D; Piqueira, José R C

2017-01-01

Capital flows are responsible for a strong influence on the foreign exchange rates and stock prices macroeconomic parameters. In volatile economies, capital flows can change due to several types of social, political and economic events, provoking oscillations on these parameters, which are recognized as economic crises. This work aims to investigate how these two macroeconomic variables are related with crisis events by using the traditional complex measures due to Lopez-Mancini-Calbet (LMC) and to Shiner-Davison-Landsberg (SDL), that can be applied to any temporal series. Here, Ibovespa (Bovespa Stock Exchange main Index) and the "dollar-real" parity are the background for calculating the LMC and SDL complexity measures. By analyzing the temporal evolution of these measures, it is shown that they might be related to important events that occurred in the Brazilian economy.

Banking, debt, and currency crises in developed countries: stylized facts and early warning indicators

Czech Academy of Sciences Publication Activity Database

Babecký, J.; Havránek, T.; Matějů, Jakub; Rusnák, M.; Šmídková, K.; Vašíček, B.

2014-01-01

Roč. 15, December (2014), s. 1-17 ISSN 1572-3089 Institutional support: RVO:67985998 Keywords : crises * developed countries * early warning indicators Subject RIV: AH - Economics Impact factor: 1.506, year: 2014

REFLECTIONS ON BEHAVIORAL CRISES PREVENTION AND INTERVENTION IN SPECIAL EDUCATION SCHOOLS IN THE UNITED STATES

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Roland PAULAUSKAS

2011-04-01

Full Text Available The development of civilization made crises an inseparable part of our lives. Crises manifest themselves in almost all social areas and organizations, including educational institutions. The goals of the article are to present a theoretical model of normal, deviant and antisocial behaviors, and discuss the psycho-social characteristics of emotionally disturbed adolescents situated in a residential special education school in the United States. The article also gives an analysis of their most prevalent behavioral crises, escalation stages, as well as nonviolent crisis prevention and intervention strategies. The methods that were used include scientific literature review, analysis of statistical information supplied from different government sources, review and analysis of student records, as well as the author’s analytical reflections in working with emotionally disturbed youngsters in residential special education schools in the United States.The results of the study indicate that scientists from different fields use different terminology to describe socially nonconforming behaviors. The author presents a theoretical model of normal, deviant and antisocial behavior that could enhance better understanding and identification of high risk situations and conduct leading to serious crises. The analysis of student records revealed that most of the adolescents situated in special education residential schools are diagnosed with a number of mental health problems. This suggests that the currently prevailing care and education paradigm in the special education residential schools should shift to a more comprehensive treatment paradigm. The article also discusses the pros and cons of nonviolent crisis intervention. It is the author’s opinion that all special education schools serving children with emotional disorders should adopt one of the nonviolent crisis intervention models and develop and implement crisis management policies, plans and procedures.

Marketing Crises in Tourism: Communication Strategies in the United States and Spain.

Science.gov (United States)

Gonzalez-Herrero, Alfonso; Pratt, Cornelius B.

1998-01-01

Compares crisis-response strategies of marketing-communication professionals in tourism organizations (TOs) in the United States and Spain. Reports the extent to which they use proven crisis-management strategies. Indicates significant differences between the countries' TOs in both their extant plans for responding to marketing crises and in their…

Variations of Young Germans' Informal Conceptions of Financial and Economic Crises Phenomena

Science.gov (United States)

Aprea, Carmela; Sappa, Viviana

2014-01-01

The development of a sound understanding of financial and economic crises phenomena must be considered an important goal within the scope of citizenship, economic and social science education. As with every other educational endeavour, this intention requires solid information about what informal conceptions learners hold about this specific…

A crise do socialismo analisada no calor da hora

Directory of Open Access Journals (Sweden)

Reginaldo Benedito Dias

2009-11-01

Full Text Available O presente artigo demonstra como os acontecimentos que levaram à crise e desintegração dos países do bloco soviético foram analisados no calor dos acontecimentos, tomando como parâmetro os livros "Nós, o povo" e "A desintegração do monolito", selecionados por causa das diferentes perspectivas metodológicas e ideológicas que representam.  

[Adolescent crises in puberty. Diagnosis and therapy (author's transl)].

Science.gov (United States)

Müller-Küppers, M

1979-08-24

Psychological disorders which become manifest as adolescent crises must be seen as complex phenomena and treated thoroughly: besides the genetic, biographic and psychosocial background of the youthful individual the cultural and economic aspects play an important role. Nevertheless we must admit that associated causal explanations, e.g. for accelerated or late development are lacking. Focal points for the subsequent symptom complexes of sexual behavior in puberty are: psychosexual prematurity or retardation, masturbation, homosexual relations, pubertal asceticism and premature and frequently changing sexual relations.

East Asian Financial Cycles: Asian vs. Global Financial Crises

OpenAIRE

Akira Kohsaka; Jun-ichi Shinkai

2014-01-01

We examine the role of financial shocks in business cycles in general and in financial crises in particular in East Asia (Indonesia, Korea, Malaysia and Thailand) since the 1990s. Estimating a Financial Conditions Index, we found that financial shocks explain most of business downturns in all the economies in the Asian Financial Crisis (AFC) in 1997-98, but that the effects of financial shocks are diverse across economies in the Global Financial Crisis (GFC) in 2008-09. In the GFC, the financ...

Banking, debt, and currency crises in developed countries: stylized facts and early warning indicators

Czech Academy of Sciences Publication Activity Database

Babecký, J.; Havránek, T.; Matějů, Jakub; Rusnák, M.; Šmídková, K.; Vašíček, B.

2014-01-01

Roč. 15, December (2014), s. 1-17 ISSN 1572-3089 Institutional support: PRVOUK-P23 Keywords : crises * developed countries * early warning indicators Subject RIV: AH - Economics Impact factor: 1.506, year: 2014

Managing urban water crises: adaptive policy responses to drought and flood in Southeast Queensland, Australia

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Brian W. Head

2014-06-01

Full Text Available In this case study, I examine the quality of decision-making under conditions of rapidly evolving urban water crises, and the adaptive policy challenges of building regional resilience in response to both drought and flood. Like other regions of Australia, Southeast Queensland has been subject to substantial cycles of drought and flood. I draw on resilience literature concerning sustainability, together with governance literature on policy change, to explain the changing awareness of urban water crises and the strategic options available for addressing these crises in this case study. The problem of resilience thinking opens up a number of important questions about the efficacy and adaptability of the policy system. The case provides insights into the interplay between the ways in which problems are framed, the knowledge bases required for planning and decision-making, the collaborative governance processes required for managing complex and rapidly evolving issues, and the overall capacity for policy learning over time. Regional resilience was proclaimed as a policy goal by government, but the practices remained largely anchored in traditional technical frameworks. Centralized investment decisions and governance restructures provoked conflict between levels of government, undermining the capacity of stakeholders to create more consensual approaches to problem-solving and limiting the collective learning that could have emerged.

Redes sociais, poder e saúde à luz das classes populares numa conjuntura de crise

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Victor Vincent Valla

2000-08-01

Full Text Available A crise do Estado provedor, provocada pelo processo de globalização, afeta de maneira dramática a relação das classes populares com os serviços de saúde no Brasil. O surgimento de um mundo neo-liberal, concentrador de renda e excludente necessariamente aponta para a construção de um outro mundo, em que a sobrevivência estará íntimamente relacionada com a solidariedade. Se não fosse por essa crise, talvez uma proposta como a do apoio social na área de saúde não chamasse tanto atenção. No entanto, uma vez "aberta a janela" para ver com mais cuidado essa proposta, é possível reconhecer que ela possui legitimidade por seus próprios méritos, e até independe da própria crise. A discussão do apoio social como proposta de educação e saúde abre a perspectiva de abordar uma questão que freqüentemente gera contradições no meio dos mediadores de educação popular: a religiosidade das classes populares. É algo a ser superado com o tempo, ou é parte integrante da cultura popular?

Redes sociais, poder e saúde à luz das classes populares numa conjuntura de crise

Directory of Open Access Journals (Sweden)

Victor Vincent Valla

Full Text Available A crise do Estado provedor, provocada pelo processo de globalização, afeta de maneira dramática a relação das classes populares com os serviços de saúde no Brasil. O surgimento de um mundo neo-liberal, concentrador de renda e excludente necessariamente aponta para a construção de um outro mundo, em que a sobrevivência estará íntimamente relacionada com a solidariedade. Se não fosse por essa crise, talvez uma proposta como a do apoio social na área de saúde não chamasse tanto atenção. No entanto, uma vez "aberta a janela" para ver com mais cuidado essa proposta, é possível reconhecer que ela possui legitimidade por seus próprios méritos, e até independe da própria crise. A discussão do apoio social como proposta de educação e saúde abre a perspectiva de abordar uma questão que freqüentemente gera contradições no meio dos mediadores de educação popular: a religiosidade das classes populares. É algo a ser superado com o tempo, ou é parte integrante da cultura popular?

Currency crises and the evolution of foreign exchange market: Evidence from minimum spanning tree

Science.gov (United States)

Jang, Wooseok; Lee, Junghoon; Chang, Woojin

2011-02-01

We examined the time series properties of the foreign exchange market for 1990-2008 in relation to the history of the currency crises using the minimum spanning tree (MST) approach and made several meaningful observations about the MST of currencies. First, around currency crises, the mean correlation coefficient between currencies decreased whereas the normalized tree length increased. The mean correlation coefficient dropped dramatically passing through the Asian crisis and remained at the lowered level after that. Second, the Euro and the US dollar showed a strong negative correlation after 1997, implying that the prices of the two currencies moved in opposite directions. Third, we observed that Asian countries and Latin American countries moved away from the cluster center (USA) passing through the Asian crisis and Argentine crisis, respectively.

Employee Communicative Actions and Companies' Communication Strategies to Mitigate the Negative Effects of Crises

DEFF Research Database (Denmark)

Mazzei, Alessandra; Ravazzani, Silvia

2013-01-01

commitment is at the basis of positive employee communicative actions, like advocacy and positive referrals, which finally protect the company’s reputation. After a theoretical exploration of these issues, this chapter presents first a case study showing how continuous internal communication efforts...... and factual communication based on managers’ and company’s actions are crucial in order to build quality relationships with employees. In turn, this leads to positive employee communicative actions when a crisis occurs. Second, it illustrates a survey of Italian companies which examined internal crisis...... reputation. The chapter concludes that employee communicative actions are fundamental in order to protect the company’s reputation in case of crises. In addition, during crises it is important to sustain the positive relationship capital developed during the pre-crisis phase by means of accommodative...

Regional Economic Resilience: Resistance and Recoverability of Resource-Based Cities during Economic Crises in Northeast China

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Juntao Tan

2017-11-01

Full Text Available This paper quantitatively analyzes the economic resilience of resource-based cities (RBCs in Northeast China in terms of resistance and recoverability during two economic crises: the Asian financial crisis and the global financial crisis. Moreover, it analyzes the main factors that affected regional resilience. There are three main findings. First, the RBCs in general demonstrated poor resistance during both recessions, but there were variations among the different types of RBCs. Petroleum and metal cities demonstrated the most resistance, whereas coal cities performed the worst. Second, the influential factors affecting economic resilience varied across the two economic cycles, but location advantage, research and development (R and D intensity, foreign trade dependence ratio, and supporting policies had positive effects on resilience during both economic cycles, while the proportion of employed persons in resource industries had a negative effect. Industrial diversity had a weak and ambiguous effect on resilience. Third, the secondary industry was more resilient during the Asian financial crisis, but the tertiary industry was more resilient during the global financial crisis. This shift may be attributed to both the nature of the crises and the strength of the sectors at the time of the crises.

A Simple Model of Monetary Policy and Currency Crises

OpenAIRE

Philippe AGHION; Philippe BACCHETTA; Abhijit BANERJEE

1999-01-01

This paper analyzes the optimal interest rate policy in currency crises. Firms are credit constrained and have debt in domestic and foreign currency, a situation that may easily lead to a currency crisis. An interest rate increase has an ambiguous effect on firms since it both makes more difficult to borrow and may decrease the foreign currency debt burden. In some cases it is actually best to decrease the interest rate. We also show how these issues are related to development of the financia...

A Simple Model of Monetary Pollicy and Currency Crises

OpenAIRE

Aghion, Philippe; Bacchetta, Philippe; Banerjee, Abhijit

1999-01-01

This paper analyzes the optimal interest rate policy in currency crises. Firms are credit constrained and have debt in domestic and foreign currency, a situation that may easily lead to a currency crisis. An interest rate increase has an ambiguous effect on firms since it both makes more difficult to borrow and may decrease the foreign currency debt burden. In some cases it is actually best to decrase the interest rate. We also show how these issues are related to the development of the finan...

The role of corporate governance in preventing economic crises

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Marek Matuszak

2012-12-01

Full Text Available The author discusses the role of corporate governance in preventing economic crises, both in the enterprise and in the economy. The article is based on the research of literature. It presents the concept of corporate governance, crisis, and factors affecting the effectiveness of the supervisory board. In the final part, it presents the principles of effective corporate governance established by the OECD, and the recommendations for redefining of the rules resulting from the analysis of experiences of the last global financial crisis.

The Critical Role of Crisis Communication Plan in Corporations’ Crises Preparedness and Management

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Agnes Lucy Lando

2014-06-01

Full Text Available Many corporations have a Crisis Management Plan (CMP, which is designed to handle crises. These plans may include crisis response drills, evacuation plans, and standby machines/generators. However, when it comes to communication during a crisis, many organizations are ill-prepared because they lack a Crisis Communication Plan (CCP. Following the September 21, 2013 attack on the Westgate Mall in Nairobi, the public’s praises for the security forces swiftly degenerated into blame, insults, and expressions of betrayal. The government seemed unprepared. There was no clearly spelt out CCP detailing what and when to release information, as well as who and how to make the release. Hence, every step the government took to give updates about the attack and what it was doing to secure the mall and save people was challenged by the media and the public. The lack of a CCP was evident in the presentation of several spokespersons by the authorities, double talk, conflicting messages, and uncertainty on the matter. This paper thus argues that while corporations strive for a variety of strategies for crisis management, there is need to also enshrine CCP in their CMP. It utilizes Coombs’ (2012 three-stage crisis management model that carefully considers the pre-crisis, crisis, and post-crisis stages. Focusing on selected corporations in Kenya that suffered crises between June 1, 2012 and October 30, 2013, this research holds that the crises duration and negative impact could have been lessened if the organizations integrated effective CCP in their CMP.

Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry

DEFF Research Database (Denmark)

Kiss, A; Bundzikova, J; Pirnik, Z

2010-01-01

rats were injected intraperitoneally with haloperidol (1 mg/kg), clozapine (30 mg/kg), olanzapine (30 mg/kg), risperidone (2mg/kg), and vehicle (5% chremophor) and were sacrificed 60 min later by a fixative. Fos, Fos/OXY, and Fos/AVP labelings were visualized by immunohistochemistry in the SON, 5...... accessory (ACS) cell groups, and 4 distinct PVN subdivisions using a computerized light microscope. Most apparent activation of single Fos, Fos/OXY, and Fos/AVP cells was induced by clozapine and olanzapine; effects of risperidone and haloperidol were substantially lower; no colocalizations were revealed...... of risperidone and haloperidol. Variabilities in Fos distribution in the PVN, SON, and ACS induced by antipsychotics may be helpful to understand more precisely the extent of their extra-forebrain actions with possible presumption of their functional impact and side effect consequences....

Reacting to Crises: The Risk-Averse Nature of Contemporary American Public Education

Science.gov (United States)

Moran, Peter

2015-01-01

Over the past several decades, numerous arguments have been made advancing the notion that the failings of the public education system in the United States have placed the nation's national security or economic prosperity at risk. This article will examine some of these "crises" and explore how arguments claiming that the shortcomings of…

Measuring complexity in Brazilian economic crises.

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Letícia P D Mortoza

Full Text Available Capital flows are responsible for a strong influence on the foreign exchange rates and stock prices macroeconomic parameters. In volatile economies, capital flows can change due to several types of social, political and economic events, provoking oscillations on these parameters, which are recognized as economic crises. This work aims to investigate how these two macroeconomic variables are related with crisis events by using the traditional complex measures due to Lopez-Mancini-Calbet (LMC and to Shiner-Davison-Landsberg (SDL, that can be applied to any temporal series. Here, Ibovespa (Bovespa Stock Exchange main Index and the "dollar-real" parity are the background for calculating the LMC and SDL complexity measures. By analyzing the temporal evolution of these measures, it is shown that they might be related to important events that occurred in the Brazilian economy.

COMPARATIVE PERSPECTIVES IN ECONOMIC CRISES GEOGRAPHY. ECONOMIC STRATEGIES IN EU COUNTRIES

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Roxana Maria Grecu

2011-06-01

Full Text Available The strategies for structural-systemic crisis management have generated, to a geographical level, a number of differences between EU countries. These cleavages are the result of differentialmacroeconomic policies. In this context, this article has the aim of achieving a comparative approach between countries of the south, west and east of the EU space. Also our approach is focused on observing the nature of macroeconomic policies and also on identifying a "pattern" associated with a common ideal -type of "rational choice" in the efficient and effective management of systemic crises. This article aims to identify areas of growth and economic stability of a particular model of public policy and political-economic ideology, to set up a mechanism for "economic engineering”. From the methodological point of view, this article uses a quantitativemethodology, derived from mathematical analysis, statistics and stochastic, in order to explain, understand and predict the possible evolution of the systemic crises in the EU countries. The interest lies in the possibility of giving a model of macroeconomic policy for the adjustment of inflationist imbalances, labor market and pricepolicy, and also in regulating the equation of production-consumption.

Linear and nonlinear market correlations: Characterizing financial crises and portfolio optimization

Science.gov (United States)

Haluszczynski, Alexander; Laut, Ingo; Modest, Heike; Räth, Christoph

2017-12-01

Pearson correlation and mutual information-based complex networks of the day-to-day returns of U.S. S&P500 stocks between 1985 and 2015 have been constructed to investigate the mutual dependencies of the stocks and their nature. We show that both networks detect qualitative differences especially during (recent) turbulent market periods, thus indicating strongly fluctuating interconnections between the stocks of different companies in changing economic environments. A measure for the strength of nonlinear dependencies is derived using surrogate data and leads to interesting observations during periods of financial market crises. In contrast to the expectation that dependencies reduce mainly to linear correlations during crises, we show that (at least in the 2008 crisis) nonlinear effects are significantly increasing. It turns out that the concept of centrality within a network could potentially be used as some kind of an early warning indicator for abnormal market behavior as we demonstrate with the example of the 2008 subprime mortgage crisis. Finally, we apply a Markowitz mean variance portfolio optimization and integrate the measure of nonlinear dependencies to scale the investment exposure. This leads to significant outperformance as compared to a fully invested portfolio.

Improving communication during volcanic crises on small, vulnerable islands

Science.gov (United States)

McGuire, W. J.; Solana, M. C.; Kilburn, C. R. J.; Sanderson, D.

2009-05-01

Increased exposure to volcanic hazard, particularly at vulnerable small islands, is driving an urgent and growing need for improved communication between monitoring scientists, emergency managers and the media, in advance of and during volcanic crises. Information gathering exercises undertaken on volcanic islands (Guadeloupe, St. Vincent and Montserrat) in the Lesser Antilles (eastern Caribbean), which have recently experienced - or are currently experiencing - volcanic action, have provided the basis for the compilation and publication of a handbook on Communication During Volcanic Emergencies, aimed at the principal stakeholder groups. The findings of the on-island surveys point up the critical importance of (1) bringing together monitoring scientists, emergency managers, and representatives of the media, well in advance of a volcanic crisis, and (2), ensuring that procedures and protocols are in place that will allow, as far as possible, effective and seamless cooperation and coordination when and if a crisis situation develops. Communication During Volcanic Emergencies is designed to promote and encourage both of these priorities through providing the first source-book addressing working relationships and inter-linkages between the stakeholder groups, and providing examples of good and bad practice. While targeting the volcanic islands of the eastern Caribbean, the source-book and its content are largely generic, and the advice and guidelines contained therein have equal validity in respect of improving communication before and during crises at any volcano, and have application to the communication issue in respect of a range of other geophysical hazards.

Finansal Krizlerin Önceden Tahmin Yoluyla Değerlendirilmesi: Türkiye Örneği(Evaluation of Financial Crises in Terms of Prediction: Turkish Case

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Zeynep KARAÇOR

2006-01-01

Full Text Available The objective of this study is to evaluate today’s conjuncture with projection method for the Turkish economy by observing how leading indicators acted before the November and February Crises. In other words, some questions such as “Could November and February Crises be prevented by the help of leading indicators?”, “Did the leading indicators work for the Turkish economy?”, “If they did so, can we estimate the probable crises?”, “Can we protect from the crisis?”, “Can we manage the crisis?” are tried to be answered. To aim this goal, various macroeconomic indicators from the literature have been determined as the leading indicators of the November and February Crises. The differences in these indicators before and after the crisis will be investigated.

Gadolinium-DOTA enhanced MRI of painful osseous crises in children with sickle cell anemia

International Nuclear Information System (INIS)

Bonnerot, V.; Sebag, G.; Montalembert, M. de; Wioland, M.; Glorion, C.; Girot, R.; Lallemand, D.

1994-01-01

In order to evaluate the role of gadolinium-DOTA enhanced MRI in the management of painful osseous crises in children with sickle cell anemia (SCA), nine children with SCA underwent MRI, bone scans and ultrasonographic studies during 11 osseous crises. Imaging findings were compared with the final diagnosis: three acute osteomyelitis (AO) and 16 acute infarcts (AI). MRI could not differentiate AO from AI. The appearance of severe AI was very misleading and was similar to the usual appearance of AO, including soft tissue changes, periosteal reaction and patterns of enhancement. Gadolinium-DOTA enhanced MRI was useful for determining the anatomic site and extent of AO or AI and for distinguishing between necrotic material, fluid collection and vascularized inflammatory tissue. It can also help to guide the aspiration of intraosseous, subperiosteal and soft tissue fluid collections. (orig.)

Europe's vulnerability to energy crises

Energy Technology Data Exchange (ETDEWEB)

NONE

2008-01-15

The growing dependency of Europe as a whole on energy imports and anticipated further increases in energy prices reinforce the concerns about meeting the energy demand in the future. The objective of the Study is to identify the threats leading to potential energy crises and suggest solutions for facing, in an appropriate way, the related key challenges. In addition, the Study intends to develop a number of indicators effective enough to assess the level of different types of vulnerability, as well the overall vulnerability of a country or region, including threats to physical disruption, higher energy prices etc. The use of vulnerability indicators is highly recommended for all WEC-European countries, as well as to policy makers and market players.

Renouvellement ou crise de l’imaginaire capitaliste?

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Wolfe, Harald

2008-12-01

Full Text Available Cette contribution met en question l’imaginaire capitaliste : son noyau chez Castoriadis – maîtrise (pseudo- rationnelle, organisation bureaucratique – et ses métamorphoses contemporaines. On a parlé d’un "nouvel esprit du capitalisme" (Boltanski/Chiapello: organisation en réseau, des projets, autonomie relative du travail. Ces mutations de l’idéologie managériale et le développement correspondant de l’institution de l’organisation et du travail signifient-ils un véritable renouvellement de l’imaginaire capitaliste? Ou bien ces changements, avec leurs contradictions et leurs limites, sont-ils, au contraire, l’indice d’une crise profonde de la capacité d’innovation et de mobilisation des significations imaginaires sociales centrales du capitalisme?

Com a cabeça nas nuvens da crise dos Subprimes | Head in the clouds of the sub-prime crisis

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Yann Moulier Boutang

2009-09-01

Full Text Available Resumo o texto apresenta a crise dos subprimes como a manifestação da impossibilidade de separação entre especulação e mercado da economia-mundo. A crise atual é apontada como sendo a primeira crise global do comunismo do capital e uma interdependência entre devedores e credores. A menos que se invente um novo New Deal, que refunde os antigos direitos do Estado-providência e crie novos direitos de novos trabalhadores, não se vê meio pelo qual um programa de eutanásia da renda evitará a explosão política. Palavras-chave crise; capitalismo cognitivo; renda; economia mundial. Abstract the paper presents the subprime crisis as a manifestation of the impossibility of separating speculation and market from the world economy. The current crisis is pointed out as being the first global crisis of communism of capital and also an interdependence between debtors and creditors. Unless a new New Deal is invented, which recasts the ancient rights of the welfare state and creates new rights for new workers, there is no means by which a program of euthanasia may avoid political explosion. Keywords crisis; cognitive capitalism; rent; world economy.

Managerial Characteristics in Critical Situations Romania’s Participation within NATO at Managing Crises

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Cristian - Sorin Prună

2009-06-01

Full Text Available The defining marks of the thesis regard the creation of new scientific premises, that shouldstructure the approached issue – crises management by relating it to the present international contextcoordinates. The suggested approach has the purpose of establishing the elements which define crisisand of highlighting specific issues in the crisis management process (including in what the states’participation at maintaining peace operations and multinational operations deployed in differenttheatres of war. In the effort of organising such a scientifical background, we have tried to realizeclear, concise delimitations, by the research method – the study and analysis of the determinantfactors and conflicts. Thus, we have disclosed the characteristics of the situation and crisis state, therequirements and the stages in the crises situation management process, its characteristics,customizing the circumstances which contribute to planning the answers and establishing themoments favourable to the abolishment of the crisis or preserving it in a balance that should allowsubsequent diffuses.

A formação social do arquitecto: Crise nos cursos de arquitectura, 1968‑1969

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Gonçalo Canto Moniz

2012-10-01

Full Text Available A regulamentação da reforma do ensino da arquitectura em 1957 inicia um processo de transformações sucessivas no quotidiano dos cursos de arquitectura que irá culminar com uma crise no ano de 1969.Ao longo de uma década de funcionamento, a nova orgânica proposta pela reforma não conseguiu, na sua globalidade, introduzir uma nova pedagogia nem democratizar o funcionamento das escolas, ficando refém do autoritarismo do Ministério da Educação. No entanto, a sua rigidez científica e administrativa estimulou professores e alunos a desenvolver estratégias, quer de projecto, quer de reflexão e debate, que procuraram promover a função social do arquitecto atento aos problemas da sociedade e da cidade, por oposição ao arquitecto tecnocrático.Nos anos de 1968 e 1969 as duas escolas, tal como a universidade e a sociedade, politizam o seu discurso. Os estudantes e os professores reivindicam abertamente alterações profundas na gestão da escola, nos métodos pedagógicos e nos objectivos do ensino, exigindo a reforma da Reforma de 57.Este texto aborda os momentos críticos deste processo de consciencialização política e social dos estudantes, que procura recolocar o papel da Escola no debate sobre a formação e sobre a profissão de arquitecto. No final de 1969 as escolas de arquitectura estão em crise, porque a universidade está em crise, mas também porque a profissão está crise.

Crise du virus Ebola : Améliorer la communication scientifique et le ...

International Development Research Centre (IDRC) Digital Library (Canada)

Crise du virus Ebola : Améliorer la communication scientifique et le journalisme local en période d'urgence et après une éclosion. La World Federation of Science Journalists (WFSJ) dirige un programme régional de communication et de formation pour les journalistes locaux, dans le but d'améliorer le journalisme ...

Being in two minds: the neural basis of experiencing action crises in personal long-term goals.

Science.gov (United States)

Herrmann, Marcel; Baur, Volker; Brandstätter, Veronika; Hänggi, Jürgen; Jäncke, Lutz

2014-01-01

Although the successful pursuit of long-term goals constitutes an essential prerequisite to personal development, health, and well-being, little research has been devoted to the understanding of its underlying neural processes. A critical phase in the pursuit of long-term goals is defined as an action crisis, conceptualized as the intra-psychic conflict between further goal pursuit and disengagement from the goal. In the present research, we applied an interdisciplinary (cognitive and neural) approach to the analysis of processes underlying the experience of an action crisis. In Study 1, a longitudinal field study, action crises in personal goals gave rise to an increased and unbiased (re)evaluation of the costs and benefits (i.e., rewards) of the goal. Study 2 was a magnetic resonance imaging study examining resting-state functional connectivity. The extent of experienced action crises was associated with enhanced fronto-accumbal connectivity signifying increased reward-related impact on prefrontal action control. Action crises, furthermore, mediated the relationship between a dispositional measure of effective goal pursuit (action orientation) and fronto-accumbal connectivity. The converging and complementary results from two methodologically different approaches advance the understanding of the neurobiology of personal long-term goals, especially with respect to the role of rewards in the context of goal-related conflicts.

Methylphenidate-risperidone combination in child psychiatry: A retrospective analysis of 44 cases.

Science.gov (United States)

Javelot, H; Glay-Ribau, C; Ligier, F; Weiner, L; Didelot, N; Messaoudi, M; Socha, M; Body-Lawson, F; Kabuth, B

2014-05-01

Psychotimulant-antipyschotic combinations are frequently used in child psychiatry, but have been rarely described in the literature. We propose here a retrospective study of 44 children who received the combination methylphenidate (MPH)-risperidone (RIS). The sample is composed of children who received either MPH (n=28) or RIS (n=16) as primary treatment. A vast majority of the children had a comorbid attention deficit hyperactivity disorder (ADHD) diagnosis. For over 60% of patients, regardless of their initial monotherapy, bitherapy decreased the symptoms of ADHD and conduct disorder, sleep disorders and anxiety. Concerning the safety of the bitherapy, a compensation effect on weight gain and appetite was respectively observed in 70% and 50% of patients. Even though iatrogenic tachycardia can be encountered with both drugs, it has never been reported when they are associated and we have reported a total of 3 cases in our study. We have also observed a case of dyskinesia resolved with the discontinuation of the treatment. MPH-RIS bitherapy appears to be particularly effective in ADHD with conduct disorder symptoms. Although tolerance may limit its use, the benefit/risk ratio seems favourable for a number of children. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

Individual’s Resistance to Social Crises is Acquired in Childhood

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Burvytė Sigita

2011-12-01

Full Text Available Objective: the development of person’s resistance to crises. The aim of the study is to revealthe importance of childhood experience to the person, by acquiring resistance to crises; theneed of pedagogical help in overcoming adaptation difficulties of the first-year pupil at school.The analysis of pedagogical, psychological, philosophical literature; the analysis of empiricalresearch and statistic data; as well as the method of observation were used in the current study.Though 60 percent of preparation possibilities for life are realised until the beginning of the firstgrade, the analysis of various authors’ research, quantitative analysis and observation of firstyearpupils in the schools of Vilnius, allow us to conclude that the main reason for a difficultadaptation of first-year pupils is the prevailing belief, that individuals’ preparation for life beginsat school. Educational system is based on rendering of the knowledge rather than the developmentof thinking ability and universal recognition of the environment. Inactivated brain during infancyand early childhood reduces the possibility of mastering information provided at school, andusing it in life. Family is the basis, which provides the feeling of safety, which instils real values,which creates the conditions of developing resistance to social changes, and various adaptationalskills, which are particularly necessary in the contemporary changing society. Extra attentionshould be paid to the education of parents and preparation for responsible parenthood.

Consumo pós crise do subprime. Novos tempos na internacionalização da economia brasileira

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Leonardo Trevisan

2011-01-01

Full Text Available A preocupação com o futuro da economia brasileira já chegou aos poetas e às revistas internacionais. Os efeitos da crise do subprime fazem parte dessa preocupação. Alguns desafios, como a internacionalização das empresas brasileiras, a atualização tecnológica da produção e as expectativas de consumo no País ganharam destaque nesse processo. A reunião do G-20, no entanto, mostrou que há diferentes métodos de lidar com a crise, preservando-se a maior influência do modo norte-americano de “fazer negócio”. A inserção brasileira na economia internacional, porém, acompanha mais o novo perfil das economias emergentes, que se desenvolve independentemente da crise. Nesse caminho, a maior dificuldade para a inserção internacional eficiente do Brasil, com manutenção da mobilidade social e da tendência de alta no consumo, continua a ser a frágil relaçãointerna entre educação e competitividade.

Um mundo em crise A world in crisis

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Carlos Altamirano

2009-01-01

Full Text Available Este estudo tem por objeto analisar um segmento do pensamento argentino da década de 1930, representado no ensaísmo sobre a "alma", ou o caráter nacional. Esse ensaísmo produziu alguns textos que se transformaram, por meio da crítica, em clássicos da reflexão sobre o país - tais como Radiografía de la pampa, de Ezequiel Martínez Estrada, e Historia de una pasión argentina, de Eduardo Mallea -, e que se gestaram sobre a base de uma crise política - sua primeira exteriorização foi o golpe de Estado de 1930 - e de uma desordem mais ampla dos pontos intelectuais de referência, em consequência da falência do positivismo entre as elites culturais. O dissabor provocado pelo contexto político nacional se mesclou ao mal-estar oriundo do pensamento europeu sobre a crise - crise do espírito, da ordem liberal e do capitalismo -, e esse amálgama alimentou um estado de descontentamento intelectual que ganhou forma na reflexão ensaística. De modo cada vez mais amplo, esse gênero dá início a uma rigorosa revisão da Argentina liberal, no âmbito de cuja produção destacam-se os referidos ensaios de Martínez Estrada e de Mallea, que serão analisados na parte final do presente estudo.This study analyzes a sector of Argentine thought from the 1930s, represented in the essays on the national 'soul' or character. This essay writing produced a number of texts that were transformed, through critical appraisal, into classics on the country itself - such as Radiografía de la pampa by Ezequiel Martínez Estrada, and Historia de una pasión argentina by Eduardo Mallea - and which emerged out of a political crisis - whose first notable effect was the 1930 coup d'état - and a more widespread disruption of the intellectual points of reference caused by the exhaustion of positivism as a paradigm among the cultural elites. The unease provoked by the national political context merged with the unease stemming from European thought concerning the

A crise de sentido e o futuro das organizações

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Arnoldo José de Hoyos Guevara

2005-12-01

Full Text Available Ao pensar sobre a crise de sentido e a fragmentação do conhecimento que caracterizaram o trabalho no mundo contemporâneo, devemos nos perguntar: se trabalhamos para viver, ou vivemos para trabalhar, por isto está emergindo um novo tipo de consciência expandida (econômico social - ambiental - espiritual capaz de repensar o complexo mundo atual por meio de novas lideranças transformadoras.

Sensemaking, institutions and crises of legitimacy: the case of Nike's sweatshop

OpenAIRE

Zheng, Xiaolan

2010-01-01

The aim of this study is to explore the phenomenon of the legitimacy crisis. This is a variant of organizational crises which, although increasingly common and managerially relevant, is still under-explored. A legitimacy crisis signals a problematic relationship between the focal organization and its socio-institutional environment which calls for repairing of meaning. Having considered this, the study has developed a theoretical framework that integrates the sensemaking and institutional per...

Splenectomy versus conservative management for acute sequestration crises in people with sickle cell disease.

Science.gov (United States)

Owusu-Ofori, Shirley; Remmington, Tracey

2015-09-07

Acute splenic sequestration crises are a complication of sickle cell disease, with high mortality rates and frequent recurrence in survivors of first attacks. Splenectomy and blood transfusion, with their consequences, are the mainstay of long-term management used in different parts of the world. This is a 2015 update of a Cochrane review first published in 2002, and previously updated in 2013. To assess whether splenectomy (total or partial), to prevent acute splenic sequestration crises in people with sickle cell disease, improved survival and decreased morbidity in people with sickle cell disease, as compared with regular blood transfusions. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Haemoglobinopathies Trials Register, which comprises of references identified from comprehensive electronic database searches and handsearching relevant journals and abstract books of conference proceedings.Additional trials were sought from the reference lists of the trials and reviews identified by the search strategy.Date of the most recent search: 10 June 2015. All randomized or quasi-randomized controlled trials comparing splenectomy (total or partial) to prevent recurrence of acute splenic sequestration crises with no treatment or blood transfusions in people with sickle cell disease. No trials of splenectomy for acute splenic sequestration were found. No trials of splenectomy for acute splenic sequestration were found. Splenectomy, if full, will prevent further sequestration and if partial, may reduce the recurrence of acute splenic sequestration crises. However, there is a lack of evidence from trials showing that splenectomy improves survival and decreases morbidity in people with sickle cell disease. There is a need for a well-designed, adequately-powered, randomized controlled trial to assess the benefits and risks of splenectomy compared to transfusion programmes, as a means of improving survival and decreasing mortality from acute splenic

B-type natriuretic peptide in hypertensive crises: Diagnostic use in hypertensive urgencies and emergencies

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Sameh El Maraghi

2013-04-01

Conclusion: During hypertensive crises BNP blood level determination could have a role as a diagnostic tool for the screening of HE and its evaluation is very useful in patients admitted with acute and rapid elevation of BP to limit target organ damage.

Comment éviter la crise de l'eau | CRDI - Centre de recherches pour ...

International Development Research Centre (IDRC) Digital Library (Canada)

9 déc. 2010 ... Une crise mondiale de l'eau aux répercussions aussi tragiques que celles ... région aride ne modifie en profondeur ses pratiques de gestion de l'eau. ... Au Moyen-Orient, le traitement et la réutilisation de l'eau provenant des ...

Evidence on the Effectiveness of Water, Sanitation, and Hygiene (WASH) Interventions on Health Outcomes in Humanitarian Crises: A Systematic Review.

Science.gov (United States)

Ramesh, Anita; Blanchet, Karl; Ensink, Jeroen H J; Roberts, Bayard

2015-01-01

Water, sanitation, and hygiene (WASH) interventions are amongst the most crucial in humanitarian crises, although the impact of the different WASH interventions on health outcomes remains unclear. To examine the quantity and quality of evidence on WASH interventions on health outcomes in humanitarian crises, as well as evaluate current evidence on their effectiveness against health outcomes in these contexts. A systematic literature review was conducted of primary and grey quantitative literature on WASH interventions measured against health outcomes in humanitarian crises occurring from 1980-2014. Populations of interest were those in resident in humanitarian settings, with a focus on acute crisis and early recovery stages of humanitarian crises in low and middle-income countries. Interventions of interest were WASH-related, while outcomes of interest were health-related. Study quality was assessed via STROBE/CONSORT criteria. Results were analyzed descriptively, and PRISMA reporting was followed. Of 3963 studies initially retrieved, only 6 published studies measured a statistically significant change in health outcome as a result of a WASH intervention. All 6 studies employed point-of-use (POU) water quality interventions, with 50% using safe water storage (SWS) and 35% using household water treatment (HWT). All 6 studies used self-reported diarrhea outcomes, 2 studies also reported laboratory confirmed outcomes, and 2 studies reported health treatment outcomes (e.g. clinical admissions). 1 study measured WASH intervention success in relation to both health and water quality outcomes; 1 study recorded uptake (use of soap) as well as health outcomes. 2 studies were unblinded randomized-controlled trials, while 4 were uncontrolled longitudinal studies. 2 studies were graded as providing high quality evidence; 3 studies provided moderate and 1 study low quality evidence. The current evidence base on the impact of WASH interventions on health outcomes in humanitarian

Propagation of crises in the virtual water trade network

Science.gov (United States)

Tamea, Stefania; Laio, Francesco; Ridolfi, Luca

2015-04-01

The international trade of agricultural goods is associated to the displacement of the water used to produce such goods and embedded in trade as a factor of production. Water virtually exchanged from producing to consuming countries, named virtual water, defines flows across an international network of 'virtual water trade' which enable the assessment of environmental forcings and implications of trade, such as global water savings or country dependencies on foreign water resources. Given the recent expansion of commodity (and virtual water) trade, in both displaced volumes and network structure, concerns have been raised about the exposure to crises of individuals and societies. In fact, if one country had to markedly decrease its export following a socio-economical or environmental crisis, such as a war or a drought, many -if not all- countries would be affected due to a cascade effect within the trade network. The present contribution proposes a mechanistic model describing the propagation of a local crisis into the virtual water trade network, accounting for the network structure and the virtual water balance of all countries. The model, built on data-based assumptions, is tested on the real case study of the Argentinean crisis in 2008-09, when the internal agricultural production (measured as virtual water volume) decreased by 26% and the virtual water export of Argentina dropped accordingly. Crisis propagation and effects on the virtual water trade are correctly captured, showing the way forward to investigations of crises impact and country vulnerability based on the results of the model proposed.

Prevention of Targeted School Violence by Responding to Students' Psychosocial Crises: The NETWASS Program

Science.gov (United States)

Leuschner, Vincenz; Fiedler, Nora; Schultze, Martin; Ahlig, Nadine; Göbel, Kristin; Sommer, Friederike; Scholl, Johanna; Cornell, Dewey; Scheithauer, Herbert

2017-01-01

The standardized, indicated school-based prevention program "Networks Against School Shootings" combines a threat assessment approach with a general model of prevention of emergency situations in schools through early intervention in student psychosocial crises and training teachers to recognize warning signs of targeted school violence.…

Associação entre hipertrofia adenotonsilar, tonsilites e crises álgicas na anemia falciforme Association between adenotonsillar hypertrophy, tonsillitis and painful crises in sickle cell disease

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Cristina Salles

2009-06-01

Full Text Available OBJETIVOS: Determinar a prevalência da hipertrofia adenotonsilar obstrutiva em crianças e adolescentes portadores de anemia falciforme; investigar possível associação entre presença de mais de cinco episódios de tonsilite nos últimos 12 meses e episódios de crise álgica no mesmo período; e comparar a hemoglobina anual média entre os que apresentam e os que não apresentam hipertrofia adenotonsilar obstrutiva. MÉTODOS: Trata-se de estudo prospectivo, observacional do tipo corte transversal, com 85 crianças e adolescentes com anemia falciforme. Todos responderam questionário e avaliação otorrinolaringológica, incluindo endoscopia nasossinusal. Para o diagnóstico da hipertrofia adenotonsilar obstrutiva foram adotados os critérios de Brodsky. RESULTADOS: A prevalência da hipertrofia adenotonsilar obstrutiva foi de 55,3%. A hipertrofia adenotonsilar obstrutiva associou-se à história de dificuldade para alimentar-se (76,7 versus 23,5%; p = 0,003, presença de mais de cinco episódios de tonsilites nos últimos 12 meses (70,6 versus 29,4%; p = 0,021, roncar alto (73,0 versus 27,0%; p = 0,004 e apneia do sono assistida (71,8 versus 28,2%; p = 0,005. Portadores de hipertrofia adenotonsilar obstrutiva apresentaram maior número de infecções das vias aéreas superiores (62,5 versus 37,5; p = 0,010. Também foi observada associação entre presença de mais de cinco episódios de tonsilite nos últimos 12 meses e episódios de crise álgica no mesmo período (mediana = 12 versus 2; p = 0,017. Não houve diferença significante da hemoglobina anual média entre portadores de hipertrofia adenotonsilar obstrutiva versus hipertrofia adenotonsilar não-obstrutiva (7,6 versus 8,2 g/dL; p = 0,199. CONCLUSÃO: A prevalência da hipertrofia adenotonsilar obstrutiva foi de 55,3% em crianças e adolescentes com anemia falciforme. A presença de mais de cinco episódios de tonsilite nos últimos 12 meses associaram-se com episódios de crise �

Crise convulsive chez les abuseurs de Tramadol et caféine: à ...

African Journals Online (AJOL)

Nous rapportons Huit cas de crises convulsives diagnostiquées comme maladie épileptique après ingestion de Tramadol et d'autres substances psychotropes dont la Caféine dans une région ou maladie épileptique et addiction au café sont fréquentes. L'objectif de ce travail était d'informer les praticiens sur le risque de ...

Appui à la relance du ROCARÉ-CI en situation de crise post ...

International Development Research Centre (IDRC) Digital Library (Canada)

De son indépendance acquise en 1960 jusqu'en 1999, la Côte d'Ivoire était l'un des pays les plus stables d'Afrique et connaissait un essor économique continu grâce à ses nombreuses richesses naturelles, agricoles en particulier. À partir de 1999, le pays s'est installé dans une longue période de crise politique dont le ...

A crise interna do México e a Gripe Suína

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Pedro dos Santos de Borba

2009-05-01

Full Text Available

Desgoverno econômico e narcotráfico põem

em questão a institucionalidade do Estado Mexicano,

enquanto a Gripe Suína alardeia a crise interna.

Crise do capital e consequências societárias Crisis of the capital and consequences for the society

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José Paulo Netto

2012-09-01

Full Text Available A palestra aqui transcrita, retomando e ampliando anteriores formulações do autor, considera a série recente de crises da economia capitalista como o prólogo de uma terceira crise sistêmica que afeta o conjunto da ordem do capital. Sumaria as transformações societárias que a sinalizam desde os finais dos anos 1970 e caracteriza a nova barbárie que se anuncia, sublinhando a relação entre a militarização da vida social e o minimalismo das políticas assistencialistas.In the lecture that is transcribed here and that resumes and enlarges the author's former ideas, the recent series of crises of the capitalist economics is considered a prologue of a third system crisis that affects the whole of the order of the capital. This article written from the lecture summarizes the transformations that have signaled such a crisis from the end of the 1970s in society, and it characterizes the new barbarism that is arising, stressing the relation between the militarization of the social life and the minimalism of the assistance policies.

Role of the police in linking individuals experiencing mental health crises with mental health services

NARCIS (Netherlands)

van den Brink, Rob H. S.; Broer, Jan; Tholen, Alfons J.; Winthorst, Wim H.; Visser, Ellen; Wiersma, Durk

2012-01-01

Background: The police are considered frontline professionals in managing individuals experiencing mental health crises. This study examines the extent to which these individuals are disconnected from mental health services, and whether the police response has an influence on re-establishing

Financial Crises As the Failure of Arbitrage: Implications for Monetary Policy

OpenAIRE

Saito, Makoto; Shiratsuka, Shigenori

2001-01-01

This paper attempts to view financial crises as the failure of arbitrage among financial markets, and takes the “Japan premium” phenomenon observed in offshore money markets as an important example in favor of this view. In addition, we reconsider, from this perspective, the open market operations conducted by a central bank during a period of financial distress. The paper first derives from the existing theoretical literature several implications regarding how arbitrage among markets is prev...

How do Economic Crises Impact Firm Boundaries?

DEFF Research Database (Denmark)

Foss, Kirsten

2010-01-01

How economic crises impact the boundaries of firms has been offered virtually no attention in the literature on the theory of the firm. I review the best-known theories of the firm and identify the variables that matter for the explanation of firm boundaries. I then examine how an economic crisis...... may impact these variables and change efficient firm boundaries. The various theories of the firm have difficulties explaining how firms efficiently adapt their boundaries to such prominent characteristics of economic crisis as declining demand and increased costs of external finance. However, all...... these theories stress uncertainty as an antecedent of firm organization, and as uncertainty is also an important characteristic of an economic crisis I examine how uncertainty is allowed to play out in the various theories in order to identify what predictions we can derive from the theory regarding changes...

Bifurcations and Crises in a Shape Memory Oscillator

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Luciano G. Machado

2004-01-01

Full Text Available The remarkable properties of shape memory alloys have been motivating the interest in applications in different areas varying from biomedical to aerospace hardware. The dynamical response of systems composed by shape memory actuators presents nonlinear characteristics and a very rich behavior, showing periodic, quasi-periodic and chaotic responses. This contribution analyses some aspects related to bifurcation phenomenon in a shape memory oscillator where the restitution force is described by a polynomial constitutive model. The term bifurcation is used to describe qualitative changes that occur in the orbit structure of a system, as a consequence of parameter changes, being related to chaos. Numerical simulations show that the response of the shape memory oscillator presents period doubling cascades, direct and reverse, and crises.

Crises and (the absence of ethics: Inseparable Magdeburg spheres?

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Stephan V. Arthur

2011-06-01

Full Text Available Ethics and trust can avoid crises, just as, as recent events have clearly proved, the reverse is true. The paper is simply constructed: Section 1 provides a historical analysis; Section 2 deals with today‟s situation, drawing similarities and differences and the possible outcomes thereby arising; the final section concludes. Historical data are difficult to come by for most countries, especially when they should also be comparable across time. In general, and for this reason, US data have been used: however, the situation in other countries was little different, as will be shown, so that the data may be considered to be representative.

Resolution of psychosocial crises associated with flying in space

Science.gov (United States)

Suedfeld, Peter; Brcic, Jelena

2011-07-01

Erikson (1959) proposed a theoretical basis for healthy psychosocial development. His theory posits eight critical conflict situations throughout one's lifetime, each of which can result in a favorable or unfavorable resolution. Autobiographies, memoirs, interviews, personal diaries, and oral histories of 97 international astronauts were content analyzed to assess reported resolutions of Erikson's psychosocial crises, regardless of chronological sequence. We made comparisons across flight phases (before, during, and after), gender, nationality of home space agency, and flight duration. Astronauts reported more favorable than unfavorable outcomes across flight phases and demographic variables. Differences across demographic variables and flight phases, as well as the changes as a result of the flight are discussed.

Gestão do turismo em tempos de crises e vulnerabilidades

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Sinthya Pinheiro Costa

2017-06-01

Full Text Available As constantes crises de ordem econômica, política, social, ambiental tem acometido diversos países e afetam diretamente a gestão do turismo. Na busca pela superação das adversidades, as organizações e gestores que apresentam características resilientes tendem a preservar e restaurar suas estruturas e funções essenciais após os eventos perturbadores. Desta forma, com vistas a compor um documento de apoio para os debates sobre a gestão do turismo em tempos de crise e em situações de vulnerabilidade, se realizou um levantamento bibliográfico e eletrônico para identificar textos científicos e também de organismos internacionais que clarificassem os conceitos da resiliência e sua utilização no turismo. É preciso: a perseguir as indicações do Tourism Resilience Committee para mitigação de riscos relacionados ao turismo; b diagnosticar a capacidade resiliente de um gestor do turismo (metodologia SOBRARE visando desenvolver características capazes de tornar os sujeitos mais preparados para enfrentar e superar as adversidades; c incorporar no processo de planejamento e gestão de cidades turísticas as indicações da Campanha da ONU para tornar as cidades resilientes.

Evidence on the Effectiveness of Water, Sanitation, and Hygiene (WASH Interventions on Health Outcomes in Humanitarian Crises: A Systematic Review.

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Anita Ramesh

Full Text Available Water, sanitation, and hygiene (WASH interventions are amongst the most crucial in humanitarian crises, although the impact of the different WASH interventions on health outcomes remains unclear.To examine the quantity and quality of evidence on WASH interventions on health outcomes in humanitarian crises, as well as evaluate current evidence on their effectiveness against health outcomes in these contexts.A systematic literature review was conducted of primary and grey quantitative literature on WASH interventions measured against health outcomes in humanitarian crises occurring from 1980-2014. Populations of interest were those in resident in humanitarian settings, with a focus on acute crisis and early recovery stages of humanitarian crises in low and middle-income countries. Interventions of interest were WASH-related, while outcomes of interest were health-related. Study quality was assessed via STROBE/CONSORT criteria. Results were analyzed descriptively, and PRISMA reporting was followed.Of 3963 studies initially retrieved, only 6 published studies measured a statistically significant change in health outcome as a result of a WASH intervention. All 6 studies employed point-of-use (POU water quality interventions, with 50% using safe water storage (SWS and 35% using household water treatment (HWT. All 6 studies used self-reported diarrhea outcomes, 2 studies also reported laboratory confirmed outcomes, and 2 studies reported health treatment outcomes (e.g. clinical admissions. 1 study measured WASH intervention success in relation to both health and water quality outcomes; 1 study recorded uptake (use of soap as well as health outcomes. 2 studies were unblinded randomized-controlled trials, while 4 were uncontrolled longitudinal studies. 2 studies were graded as providing high quality evidence; 3 studies provided moderate and 1 study low quality evidence.The current evidence base on the impact of WASH interventions on health outcomes in

Identifying Partisan Slant in News Articles and Twitter during Political Crises

OpenAIRE

Karamshuk, Dmytro; Lokot, Tetyana; Pryymak, Oleksandr; Sastry, Nishanth

2017-01-01

In this paper, we are interested in understanding the interrelationships between mainstream and social media in forming public opinion during mass crises, specifically in regards to how events are framed in the mainstream news and on social networks and to how the language used in those frames may allow to infer political slant and partisanship. We study the lingual choices for political agenda setting in mainstream and social media by analyzing a dataset of more than 40M tweets and more than...

Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial.

Science.gov (United States)

Ghaleiha, Ali; Mohammadi, Effat; Mohammadi, Mohammad-Reza; Farokhnia, Mehdi; Modabbernia, Amirhossein; Yekehtaz, Habibeh; Ashrafi, Mandana; Hassanzadeh, Elmira; Akhondzadeh, Shahin

2013-12-01

A hyperglutamatergic state has been shown to play a possible role in the pathophysiology of autistic disorders. Riluzole is a glutamate-modulating agent with neuroprotective properties, which has been shown to have positive effects in many neuropsychiatric disorders. The aim of this study was to assess the efficacy and tolerability of riluzole as an adjunctive to risperidone in the treatment of irritability in autistic children who were not optimally responding to previous medications. This was a 10-week, randomized, double-blind, parallel-group, placebo-controlled trial. The study enrolled male and female outpatients aged 5-12 years with a diagnosis of autistic disorder based on the DSM-IV-TR criteria and a score of ≥12 on the Aberrant Behavior Checklist-Community (ABC-C) irritability subscale who had discontinued other medications because of a lack of efficacy. Subjects received riluzole (titrated to 50 or 100 mg/day based on bodyweight) or placebo in addition to risperidone (titrated up to 2 or 3 mg/day based on bodyweight) for 10 weeks. Patients were assessed at baseline, week 5, and week 10. The primary outcome measure was the difference in the change in the ABC-C irritability subscale score from baseline to week 10 between the two groups. We also compared changes in other ABC-C subscale scores and Clinical Global Impressions-Improvement (CGI-I) scale scores between the two groups. Forty-nine patients were enrolled in the study, and forty children completed the trial (dropouts: placebo = 4, riluzole = 5). A significantly greater improvement in the study primary outcome (the ABC-C irritability subscale score) was achieved by the riluzole-treated children compared with the placebo group (P = 0.03). Patients in the riluzole group also showed significantly greater improvement on the lethargy/social withdrawal (P = 0.02), stereotypic behavior (P = 0.03), and hyperactivity/non-compliance subscales (P = 0.005), but not on the inappropriate speech

Identity Crises in Love and at Work: Dispositional Optimism as a Durable Personal Resource

Science.gov (United States)

Andersson, Matthew A.

2012-01-01

Using the 2004 General Social Survey (N = 453), the identity stress process is investigated in terms of crises in intimate relationships and at the workplace. I discuss dispositional optimism as a psychological resource that is relatively independent of the situation and the self, making it ideal for structurally disadvantaged actors and for…

PSYCHOLOGICAL FEATURES OF SPOUSE’S EXPERIENCE OF SOME FAMILY CRISES

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Valeriya Anatolyevna Ivanchenko

2013-10-01

Full Text Available By this research authors tried to find any psychological features of spouse’s experience of some normative family crises. 24 married couples from Novosibirsk, aged 20 to 41 years, take a part in this research. There were 8 couples at the «Childless couple stage» and 16 couples at the stage «Family with young children».Purpose is an identifying of psychological characteristics of some normative family’s crisesMethodology based on using of psychodiagnostic testing with Family Adaptability and Cohesion Scale III (FACES III, test of Role expectations of partners (N.Volkova, test of  the interaction of the spouses in a conflict situation (Yu.E.Aleshina, L.Ya.Gozman, E.M.Dubovskaya and method of mathematical statistics with the Spearman rank criterion and the non- parametric Mann-Whitney U test.Results describe some psychological characteristics of spouses at the «Childless couple stage» and at the stage «Family with young children», include difference between men and women in this experience. The most important at the «Childless couple stage» is an attitude to expression of jealousy. If the family endures the crisis, spouses have an active negative reaction on an expression of jealousy. At the stage «Family with young children» at the forefront there are money disagreements, which prove an existence of family crisis from our point of view.   Practical implications are in the area of practical and scientific activity of family psychologists.DOI: http://dx.doi.org/10.12731/2218-7405-2013-7-14

Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

Science.gov (United States)

Olivares, J M; Rodriguez-Morales, A; Diels, J; Povey, M; Jacobs, A; Zhao, Z; Lam, A; Villalobos Vega, J C; Cuéllar, J Alonso; de Castro, F J Alberca; Quintero, C Morillo-Velarde; Martíin, J F Román; Domínguez, P Tabares; Ojeda, J L Prados; Cortés, S Sanz; Cala, F I Mata; Marín, C Gutiérrez; Castro, L Moyano; Duaso, M A Haza; Albarracín, J Requena; Vergara, G Narbona; Benítez, A Fernández; Cleries, F Mayoral; Pérez-Brian, J M García-Herrera; Aragón, A Bordallo; Navarro, J C Rodríguez; Biedma, J A Algarra; de Pedro, R Bravo; González, J F Delgado; López, M E Jaén; Moreno, H Díaz; López, J A Soto; Rodríguez, E Ojeda; de Hoyos, C Martínez; Sacristán, M Pardilla; Martín, M D Molina; Ballesteros, E Martín; Rodríguez, P A Sopelana; Menéndez, L Fernández; Rivas, R Santos; del Pino Cuadrado, P; Lauffer, J Correas; Solano, J J Rodríguez; Martínez, J M Fernández; Solano, F García; Rodríguez, P García-Lamberde; Rodríguez, J A Romero; Cano, T Rodríguez; Fortacin, M Ducaju; Lobeiras, J M Blanco; Sampedro, J M Piñeiro; Bravo, A Pérez; Pellicer, A Fernández; López, M D Alonso; Liste, J Fraga; Fernández, M Riobo; Losada, A Casas; Mendez, R Vazquez-Noguerol; Romero, S Agra; Blanco, J J Blanco; Bonaselt, I Tortajada; Mahia, M C García; del Valle, E Ferrer Gómez; Yañez, P Quiroga; Camarasa, M Gelabert; Alonso, J A Barbado; Mendez, G Florez; Feliz, F Doce; Lamela, M A López; Piñero, M Vega; Alvarado, P Fuentes; Gómez, I López; Martín, P Fadon; Gómez, J L Santos; López, A García; Jiménez, A Rodríguez; Nafs, A Escudero; Barquero, N Casas; Ortiz, R Fernández-Villamor; Noguera, J L Velez; Carrasco, P Ruiz; Muñoz, J Martín; Palma, M Masegoza; Hortelano, C Marín; Bonome, L Sánchez; Sevilla, J Sánchez; Juan, J M Mongil San; Ramos, J M García; Muñoz, J L Vallejo; Guisasola, J Elorza; Vazquez, L Santamaria; Guerras, F Campo; Nebot, F J Arrufat; Fernández, F J Baron; Nicolau, A L Palomo; Subirats, R Catala; Kidias, M Messays; Navarro, V Fabregat; García, B Frades; del Rosal, F Mejias; de Vicente Muñoz, T; Ballester, J Año; Lieb, P Malabia; Martel, A Delgado; Bea, E Roca; Joaquim, I Grau; Enjuanes, F Boatas; Piñol, M Bañuelos; Carbonell, E Fontova I; Muñoz, R Martín; Giribets, C Argila; Sans, L Albages; Blanco, A Serrano; Felipe, M Arcega; Muñoz, P González; Villanueva, A Pons; Arroyo, M Bernardo; Borri, R Coronas; Fallada, S Miret; Merola, M Celma; Rodon, E Parellada; Palmes, J R Pigem; Martínez, E Pérez; Catala, J Matarredona; Coca, A Sandoval; Ferrandiz, F Pascual; Paya, E Ferrandiz; Caballero, G Iturri; Bonet, A Franco; Figueras, J Fluvia; Pagador, P Moreno; Garibo, M Medina; Camo, V Pérez; Carrillo, C Sanz; Valero, C Pelegrin; Rebollo, F J Caro; García Campayo, J; Sala Ayma, J M Sala; Roig, M Martínez; de Uña Mateos, M A; Bertolin, R García; García, A Martín; Mazo, F Jiménez; Velasco, J L Galvez; Pérez, L Santa Maria; Casado, C Jiménez; Barba, J J Mancheño; Diaz, M Conde; Rubio, J P Alcon; Mandoli, A Soler; Herrero, A Uson; Martínez, A Rodríguez; Serrano, P Salgado; Rodríguez, E Nieto; Montesinos, J Segui; Macia, J Ferragud; Mateos Marcos, A Mateos; Soto, J V Pérez-Fuster; Dumont, M Verdaguer; Pagan, J Parra; Martínez, V Balanza; Santiuste de Pablos, M; Delgado, C Espinosa; Quiles, M D Martínez; López, F J Manzanera; Navarro, P Pozo; Torres, A Micol; Ingles, F J Martínez; Arias-Camison, J M Salmeron; Manzano, J C López; Peña, R Villanueva; Guitarte, G Petersen; Fontecilla, H Blasco; Romero, J Barjau; Gil, R Sanz; Lozano, J Marín; Adanez, L Donaire; Zarranz Herrera-Oria, I; Jiménez, J Pérez; Vaz, F Carrato; García, O Sanz; Anton, C Contreras; Casula, R Reixach; Hernandez, M C Natividad; Escabias, F Teba; Torresano, J Rodríguez; Pérez-Villamil, A Huidobro; Estevez, L; Figuero, M Aragües; Muñoz de Morales, A; Calvin, J L Rodríguez; Criado, M Delgado; Rodríguez, V Molina; Ambrosolio, E Balbo; Madera, P M Holgado; Alfaro, G Ponce; Vidal, M M Rojas; Valtuille, A García; Ruiz, O; Cabornero, G Lucas; Echevarria Martínez de Bujo, M; Mallen, M J Maicas; Puigros, J Santandreu; Martorell, A Liñana; Forteza, A Clar; Arrebola, E Rodríguez; Rodríguez de la Torre, M; Saiz, C G Anton; Bardolet I Casas, C; Linde, E Rodríguez; De Arce Cordon, R; Molina, E M Padial; Carazo, F J Ruiz; Romero, J J Muro; Cano, D Vico; Dorado, M Soria; Velazquez, S Campos; Sánchez, A J Rodríguez; Leon, S Ocio; Sánchez, K Pachas; Benitez, M Henry; Zugarramurai, A Intxausti; Contreras, M A; De la Varga González, M; Marín, P Barreiro; Robina, F Gómez; García, M Sánchez; Pérez, F J Otero; Bros, P Cubero; Gómez, A Carrillo; de Dios Molina Martín, J; Perera, J L Carrasco; Averbach, M C; Perera, J L Carrasco; Palancares, E Goenaga; Gallego de Dios, M T; Rojo, C Fernández; Iglesias, S Sánchez; Merino, M I Rubio; Mestre, N Prieto; Urdaniz, A Pérez; Sánchez, J M Martínez; Seco, R Gordo; Muñoz, J Franco; Agut, M Mateos; Lozano, M L Blanco; Herguedas, F Martín; Pena, A Torcal; García, J Vicente; Martínez, A Varona; Sanz Granado, O Sanz; Fernández, M A Medina; Canseco, J M Moran; López, P A Megia; Martín, M A Franco; Barrio, J A Espina; Ubago, J Giner; Bennassar, M Roca; Díez, J M Olivares; Fleta, J L Hernandez; Fortes, F Porras; López, C Arango; Medina, O; Alvarez, D Figuera; Roca, J M Peña; Valladolid, G Rubio; Tavera, J A Furquet; García-Castrillon Sales, J A; Llordes, I Batalla; Melgarejo, C Anchuistegui; Cañas de la Paz, F; Callol, V Vallés; García, M Bousoño; García, J Bobes; Leal, F J Vaz; Corrales, E Cáceres; Iglesias, E Sánchez; Gómez, M A Carreiras; Serrano, G García; Chillarón, E G Román; Aguado, F J Samino; Castillo, J J Molina; González, A González; Vázquez, J Gallardo; Peralvarez, M Bolivar; Diaz, M Rios; Mesa, M Ybarzabal; Artiles, F J Acosta; Chao, M Ajoy; Mesa, M Ybarzabal; del Rosario Santana, P; Escudero, M A García; Berenguer, M Molla; Llacer, J M Bonete; Berna, J A Juan; Ortiz, J Barragán; Pardell, L Tost; Hernández-Alvarez de Sotomayor, C; Méndez, M R Cejas; Garate, R Cabrera; Múgica, B Díaz; González, M Caballero; Domingo, J Pujol; Navarro, C Sáez; Vera, G Selva; Cuquerella, M A; Monzo, J Lonjedo; Boada, P Cervera; Pérez, M F Martín; Parrado, E Carrasco; Sánchez, J J Yañez; Fernández, J Calvo

2009-06-01

The electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice. Parameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n=1345) or a new oral antipsychotic (AP) (n=277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review. At 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs, p<0.0001) and reduction in Clinical Global Impression Severity scores (-1.14 for RLAI versus -0.94 for APs, p=0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2, p<0.05) and days (18.74 versus 13.02, p<0.01) of hospitalizations at 24 months than oral AP patients. This 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

The scientific management of volcanic crises

Science.gov (United States)

Marzocchi, Warner; Newhall, Christopher; Woo, Gordon

2012-12-01

Sound scientific management of volcanic crises is the primary tool to reduce significantly volcanic risk in the short-term. At present, a wide variety of qualitative or semi-quantitative strategies is adopted, and there is not yet a commonly accepted quantitative and general strategy. Pre-eruptive processes are extremely complicated, with many degrees of freedom nonlinearly coupled, and poorly known, so scientists must quantify eruption forecasts through the use of probabilities. On the other hand, this also forces decision-makers to make decisions under uncertainty. We review the present state of the art in this field in order to identify the main gaps of the existing procedures. Then, we put forward a general quantitative procedure that may overcome the present barriers, providing guidelines on how probabilities may be used to take rational mitigation actions. These procedures constitute a crucial link between science and society; they can be used to establish objective and transparent decision-making protocols and also clarify the role and responsibility of each partner involved in managing a crisis.

Financial Restructuring in Banking and Corporate Sector Crises: What Policies to Pursue?

OpenAIRE

Stijn Claessens; Daniela Klingebiel; Luc Laeven

2001-01-01

We review the literature on resolving bank and corporate sector crises to identify government policies that affect the depth of a crisis and the ease and sustainability of recovery, and to analyze their fiscal cost. A consistent framework - including sufficient resources for loss-absorption and private agents facing the right framework of sticks and carrots - is the, although often missing key to successful bank and corporate restructuring. Sustainability of restructuring calls for deeper str...

Um olhar sobre a atenção psicossocial a adolescentes em crise a partir de seus itinerários terapêuticos

Directory of Open Access Journals (Sweden)

Melissa de Oliveira Pereira

2014-10-01

Full Text Available O artigo analisa a assistência a adolescentes em crise em um município da região metropolitana do Rio de Janeiro, Brasil. Trata-se do relato de uma pesquisa qualitativa em saúde, que utiliza como recursos metodológicos o Itinerário Terapêutico e as Narrativas de Vida, adotando como principal referência teórica o psicanalista René Kaës. Buscou-se, valendo-se de relatos orais, apreender realidades coletivas que lançassem luzes sobre as distintas lógicas assistenciais e práticas profissionais de cuidado a adolescentes em situação de crise psicossocial. Partiu-se do pressuposto de que, ao ser tomada em seu caráter dialético, a crise exige a existência e a manutenção de um enquadre que permita o estabelecimento de um espaço de transição, no qual se construam condições necessárias para que elementos disruptivos e paradoxais sejam elaborados. No entanto, a atenção à crise no contexto estudado mostrou-se atravessada por dificuldades de infraestrutura e baseada em certa rigidez institucional e fragmentação das ações, com pouco direcionamento para um trabalho intersetorial.

Política monetária em tempos de crise

Directory of Open Access Journals (Sweden)

Vladimir K. Teles

2013-12-01

Full Text Available O presente artigo busca investigar como crises causadas por choques externos, como sudden-stops e choques nos termos de troca, afetaram a economia brasileira. Para tanto propomos um modelo teórico simples de cash-in-advance com fricções financeiras de forma que choques de liquidez causam mudanças na alocação dos fatores de produção e na produtividade da economia. Em seguida, o modelo é estimado para a economia brasileira e as implicações para política monetária são analisadas.

Um olhar sistêmico sobre a crise norte-americana

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CHRISTIAN CARVALHO GANZERT

Full Text Available RESUMO No contexto contemporâneo, a economia global pode ser descrita como um sistema baseado em agentes que, quando associados, manifestam seus próprios meios e fins. A crise das hipotecas subprime nos Estados Unidos é um bom exemplo das implicações desse tipo de relacionamento. Ela está diretamente relacionada a poderosos laços de realimentação, compostos por uma série de variáveis que amplificaram o fato de as famílias americanas terem se endividado em ritmo maior do que a sua distribuição de riqueza, prejudicada pela externalização da produção. Há atualmente uma nova estrutura na economia internacional, em que as ex-nações subdesenvolvidas estão mais bem posicionadas no cenário macroeconômico e têm maior poder do que antes - uma consequência do necessário rearranjo sistêmico. Diante dessa complexa dinâmica, a função de inteligência que deveria controlar e garantir a estabilidade sistêmica falhou em perceber a dinâmica e os impactos da nova cultura atrelada ao comportamento do capital contemporâneo, para evitar a perda da hegemonia. Observando-se ex post facto, por meio de um enfoque sistêmico, a crise econômica americana pode ser definida como tendo suas raízes nas premissas de todo o arcabouço cultural da globalização que acabou por conduzir à externalização da produção. Assim, o contexto sistêmico desta análise aponta que a cultura, como importante gerador e amplificador, deve ser o principal foco dos intentos de análise do atual contexto socioeconômico global.

l-Carnosine As an Adjunctive Therapy to Risperidone in Children with Autistic Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

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Hajizadeh-Zaker, Reihaneh; Ghajar, Alireza; Mesgarpour, Bita; Afarideh, Mohsen; Mohammadi, Mohammad-Reza; Akhondzadeh, Shahin

2018-02-01

This study aimed at investigating the efficacy and tolerability of l-carnosine as an add-on to risperidone in the management of children with autism. This was a 10-week, randomized, double-blind, placebo-controlled study. Seventy drug-free children aged 4-12 years old with a diagnosis of autism spectrum disorder (ASD), according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (DSM-5) who had an Aberrant Behavior Checklist-Community (ABC-C) scale irritability subscale score of ≥12, entered the study. The patients were randomly assigned to l-carnosine (800 mg/day in 2 divided doses) or placebo in addition to risperidone titrated up to 2 mg/day (based on body weight) for 10 weeks. The children were assessed by using ABC-C at baseline and weeks 5 and 10 post-baseline. The primary outcome measure was the mean change in the ABC-C irritability subscale score, and other subscale scores were defined as secondary outcomes. Using the general linear model repeated measures, no significant effect was observed for time × treatment interaction on the irritability subscale scores. However, significant effect was detected on the hyperactivity/noncompliance subscale [F (1.62, 64.96) = 3.53, p-value = 0.044]. No significant improvements were obtained on the lethargy/social withdrawal, stereotypic behavior, and inappropriate speech subscale scores. Significantly greater score reduction in the hyperactivity/noncompliance subscale occurred in the l-carnosine group compared with the placebo group at the end of the trial. Extrapyramidal Symptom Rating Scale Scores and its changes did not differ between the two groups. The frequency of other side effects was not significantly different between the two groups. Although no significant difference was detected on the irritability subscale scores, l-carnosine add-on can improve hyperactivity/noncompliance subscales of the ABC-C rating scale in patients with ASD.

The transmission process of financial crises across the emerging markets: an alternative consideration

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Abdurrahman, Korkmaz

2012-01-01

This paper offers an alternative consideration for the transmission process of financial crises across emerging markets. Here, we hypothesized that the interdependence effect could weaken, even disappear completely, and veer during a crisis period as a result of the contagion process. The importance of this hypothesis for the policy implication is also highlighted because it can be validated for many cases by our data.

The Continuing Challenge of Racial Conflicts and Crises: Focusing on Education as a Solution

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Brown, Lionel H.; Larsen, Judith; Britt, Ruth S.; Yao, Yao; Brown, Jean P.; Beck, Ryan

2006-01-01

In this first-person paper, educator Dr. Lionel Brown takes a sweeping look at the racial crises that have erupted in his home city of Cincinnati during his lifetime, and proposes that education is the only real, long-term way of addressing and disrupting the repeating pattern of violence. He highlights a selection of current and proposed…

DIVERSIFICAÇÃO INTERNACIONAL DE MACROCARTEIRAS EM CONTEXTO DE CRISES FINANCEIRAS

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Carol Thiago Costa

2012-01-01

Full Text Available O presente trabalho tem por objetivo mensurar o grau de correlação entre as bolsas de valores de alguns países considerados emergentes, segundo o Fundo Monetário Internacional (2009, adotando para tal dois períodos distintos, um anterior e outro durante a crise financeira do subprime em 2008, a partir de informações diárias de fechamento dos índices representativos daquelas bolsas. O período está compreendido entre 28 de junho de 2007 a 03 de abril de 2009, totalizando 438 observações para cada bolsa. As técnicas estatísticas abrangem o teste de correlação de Pearson e o teste de correlação móvel, este empregando um período de aproximadamente seis meses. Os principais resultados revelam que, em momentos de instabilidade financeira, tais como o da crise do subprime, em 2008, as correlações entre as bolsas de valores mudam significativamente, convergindo para um valor próximo a um (1, indicando que os mercados caminham de maneira paralela, com poucas opções para a estratégia de diversificação internacional de portfólios de investimento. Palavras-clave: Diversificação internacional. Portfólios de investimento. Correlação. Correlação móvel.

Role of social media and networking in volcanic crises and communication

Science.gov (United States)

Sennert, Sally K.; Klemetti, Erik W.; Bird, Deanne

2017-01-01

The growth of social media as a primary and often preferred news source has contributed to the rapid dissemination of information about volcanic eruptions and potential volcanic crises as an eruption begins. Information about volcanic activity comes from a variety of sources: news organisations, emergency management personnel, individuals (both public and official) and volcano monitoring agencies. Once posted, this information is easily shared, increasing the reach to a much broader population than the original audience. The onset and popularity of social media as a vehicle for eruption information dissemination has presented many benefits as well as challenges, and points towards a need for a more unified system for information. This includes volcano observatories using social media as an official channels to distribute activity statements, forecasts and predictions on social media, in addition to the archiving of images and data activity. This chapter looks at two examples of projects that collect / disseminate information regarding volcanic crises and eruptive activity utilizing social media sources. Based on those examples, recommendations are made to volcanic observatories in relation to the use of social media as a two-way communication tool. These recommendations include: using social media as a two-way dialogue to communicate and receive information directly from the public and other sources; stating that the social media account is from an official source; and, posting types of information that the public are seeking such as images, videos and figures.

Are We Prepared? Four WMD Crises That Could Transform U.S. Security

Science.gov (United States)

2009-06-01

biological attack, as well as for food se- curity associated with meat , poultry , and eggs. ✦ Defense is primarily responsible for activities relat...to mitigate the risks posed by sev- eral “systemic game -changers” that could fundamentally alter America’s ability to respond to future crises. More...capabilities and units, this mis- sion is still predominantly a “U.S.-only” game , as the United States is the only country that can field elimi- nation

Building joint capacity: the role of European Union agencies in the management of trans-boundary crises

NARCIS (Netherlands)

Boin, A.; Busuioc, M.; Groenleer, M.

2011-01-01

This paper focuses on the growing role of European Union (EU) agencies in the management of trans-boundary crises. It makes this development explicit, demonstrating that the emergence of multiple agencies with specific crisis preparation or response tasks has transformed the EU’s crisis management

Crise financeira, estado e regularização jurídica Financial crisis, state and legal regularization

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Nildo Viana

2009-12-01

Full Text Available O Presente artigo discute a questão da crise financeira e seus efeitos na esfera estatal e jurídica, a partir do artigo de josé eduardo faria (2009. para este autor, a crise financeira coloca questões a serem discutidas que possuem ressonância na esfera estatal e jurídica e isto produz uma situação de "poucas certezas e muitas dúvidas", sendo que existiriam cinco possibilidades apontadas por alguns analistas. A análise exposta parte de outra interpretação da crise financeira e, por conseguinte, de suas consequências sociais, bem como apresenta outras tendências e efeitos destas sobre o direito, apresentando uma concepção alternativa ao que este autor apresenta.The present discusses the subject of the financial crisis and your effects in the state and juridical sphere, starting from josé eduardo faria article (2009. para this author, the financial crisis places subjects they be discussed her that possess resonance in the state and juridical sphere and this produces a situation of "few certainties and a lot of doubts", and five pointed possibilities would exist for some analysts. The analysis exposed part of another interpretation of the financial crisis and, consequently, of your social consequences, as well as it presents other tendencies and effects of these on the right, presenting an alternative conception to the that this author presents.

Effects of cigarette smoking on priapism induced by quetiapine: a case report

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Hosseini Seyed

2012-10-01

Full Text Available Abstract Priapism is defined as an unwanted, prolonged, and painful erection which is unrelated to sexual stimulation. Some case studies suggest that priapism is an adverse effect of antipsychotic medications. In our case study a 30 year-old Iranian male with schizophrenia was experiencing recurrent priapism associated with quetiapine use. There are three interesting facts about this case: Firstly, the patient suffered priapism after even low dose consumption of quetiapine. Secondly, this case had experienced priapism with risperidone, olanzapine, and even clozapine in the past, suggesting a possible pharmacodynamic interaction of antipsychotics and inner biological traits in this particular case. Thirdly, priapism induced by low dose quetiapine was resolved after cigarette smoking.

Paul Jorion, Vers la crise du capitalisme américain

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Claude Dubar

2009-11-01

Full Text Available Paul Jorion est un anthropologue qui s’est donné comme objet de recherche le capitalisme financier américain et sa crise. Le fait n’est pas courant : passer au cours de sa carrière de chercheur de l’étude des paludiers français et de l’apprentissage de leur métier (cf. Delbos et Jorion, La transmission des savoirs, Ed. de la MSH, 1984 à l’analyse du système financier américain suppose à la fois une grande curiosité intellectuelle et une grande flexibilité mentale. L’ouvrage dont il est ici q...

Confronting ecological futures: global environmental crises in contemporary survival quests for young adults

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Yvonne Hammer

2010-01-01

Full Text Available This paper examines representations of societal concern in the futuristic ecological disaster fictions of three British authors: Julie Bertagna (Exodus; Zenith, Jan Mark (Riding Tycho; Voyager and Marcus Sedgwick Floodland. The depicted refugee journeys in these futuristic worlds speak into a growing global disquiet that surrounds current historic events. Environmental crises that ground the emergent world orders of depicted future societies set the scene in each coming of age frame: each survival quest embeds social and cultural issues recognisable to contemporary audiences in futuristic representations of changed world orders, limited resources, and isolated communities. Authors resist the mythic frame of a traditional quest journey − a call to journey, the engagement with growth through a road of trials and then celebrations in a return to home territory: their conclusions offer limited resolutions, the struggle to survive entrenched as a linear path. Because authors link depictions of the refugee subject with environmental degradation, apocalyptic scenarios that signify the devastating consequences of global environmental crises provide an ecocritical platform from which each author situates a discourse of protest. Interrogating contemporary political positions of ambiguity and denial their novels profile social justice issues experienced by refugee populations in contemporary society.

Early warning signal for interior crises in excitable systems.

Science.gov (United States)

Karnatak, Rajat; Kantz, Holger; Bialonski, Stephan

2017-10-01

The ability to reliably predict critical transitions in dynamical systems is a long-standing goal of diverse scientific communities. Previous work focused on early warning signals related to local bifurcations (critical slowing down) and nonbifurcation-type transitions. We extend this toolbox and report on a characteristic scaling behavior (critical attractor growth) which is indicative of an impending global bifurcation, an interior crisis in excitable systems. We demonstrate our early warning signal in a conceptual climate model as well as in a model of coupled neurons known to exhibit extreme events. We observed critical attractor growth prior to interior crises of chaotic as well as strange-nonchaotic attractors. These observations promise to extend the classes of transitions that can be predicted via early warning signals.

IMAGEM, MÍDIA E NOVAS TECNOLOGIAS – O DISCURSO DE VEJA EM AS CORES DA CRISE

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Welisson Marques

2012-01-01

Full Text Available Esse artigo propõe discorrer sobre análise imagética nos discursos em geral, bem como no discurso midiático em especial, em face das novas tecnologias contemporâneas. A AD (isto é, Análise do Discurso a que nos referimos é aquela erigida por Michel Pêcheux. Nesse sentido, os conceitos de intericonicidade em Courtine e policromia em Souza são profícuas ferramentas teóricas para se analisar textos não-verbais. Tomamo-los como sustentáculo para a análise da matéria As Cores da Crise, publicada em Veja na época da suposta crise do mensalão. Nesse exercício, voltar-nos-emos para a constituição do sujeito ao se referir ao Partido dos Trabalhadores e como se dá essa relação, atentando-se para os elementos verbais e não-verbais materializados no corpus.

Role of the police in linking individuals experiencing mental health crises with mental health services

Science.gov (United States)

2012-01-01

Background The police are considered frontline professionals in managing individuals experiencing mental health crises. This study examines the extent to which these individuals are disconnected from mental health services, and whether the police response has an influence on re-establishing contact. Methods Police records were searched for calls regarding individuals with acute mental health needs and police handling of these calls. Mental healthcare contact data were retrieved from a Psychiatric Case Register. Results The police were called upon for mental health crisis situations 492 times within the study year, involving 336 individuals (i.e. 1.7 per 1000 inhabitants per year). Half of these individuals (N=162) were disengaged from mental health services, lacking regular care contact in the year prior to the crisis (apart from contact for crisis intervention). In the month following the crisis, 21% of those who were previously disengaged from services had regular care contact, and this was more frequent (49%) if the police had contacted the mental health services during the crisis. The influence of police referral to the services was still present the following year. However, for the majority (58%) of disengaged individuals police did not contact the mental health services at the time of crisis. Conclusions The police deal with a substantial number of individuals experiencing a mental health crisis, half of whom are out of contact with mental health services, and police play an important role in linking these individuals to services. Training police officers to recognise and handle mental health crises, and implementing practical models of cooperation between the police and mental health services in dealing with such crises may further improve police referral of individuals disengaged from mental health services. PMID:23072687

A crise e suas fronteiras: oito meses de "mensalão" nos editoriais dos jornais

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Luis Felipe Miguel

2007-06-01

Full Text Available Com certa freqüência, a imprensa é acusada de "incendiária", alimentando as crises políticas, de forma irresponsável, na busca por melhores manchetes. A partir da análise de editoriais dos três principais jornais da imprensa brasileira entre maio e dezembro de 2005, meses do escândalo do "mensalão", este artigo observa outra faceta: como a crise é constituída como "desvio" a ser corrigido pela punição ou exclusão de determinados atores e comportamentos, impedindo que se coloque em questão os fundamentos do regime político.Press is frequently accused of being "incendiary", nourishing political crisis in an irresponsible way, in search of better headlines. This article relies on an analysis of editorial stuff of the three leading Brazilian newspapers to observe another facet: how the crisis is constituted as a "deviation" something to be corrected by punishment or exclusion of certain actors and kinds of behavior. Thus, the foundations of the political system are never put in question.

Dose reduction of risperidone and olanzapine can improve cognitive function and negative symptoms in stable schizophrenic patients: A single-blinded, 52-week, randomized controlled study.

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Zhou, Yanling; Li, Guannan; Li, Dan; Cui, Hongmei; Ning, Yuping

2018-05-01

The long-term effects of dose reduction of atypical antipsychotics on cognitive function and symptomatology in stable patients with schizophrenia remain unclear. We sought to determine the change in cognitive function and symptomatology after reducing risperidone or olanzapine dosage in stable schizophrenic patients. Seventy-five stabilized schizophrenic patients prescribed risperidone (≥4 mg/day) or olanzapine (≥10 mg/day) were randomly divided into a dose-reduction group ( n=37) and a maintenance group ( n=38). For the dose-reduction group, the dose of antipsychotics was reduced by 50%; for the maintenance group, the dose remained unchanged throughout the whole study. The Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery were measured at baseline, 12, 28, and 52 weeks. Linear mixed models were performed to compare the Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects and MATRICS Consensus Cognitive Battery scores between groups. The linear mixed model showed significant time by group interactions on the Positive and Negative Syndrome Scale negative symptoms, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, attention/vigilance, working memory and total score of MATRICS Consensus Cognitive Battery (all pNegative Syndrome Scale negative subscale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, working memory and total score of MATRICS Consensus Cognitive Battery for the dose reduction group compared with those for the maintenance group (all pnegative symptoms in patients with stabilized schizophrenia.

Random Acts of Senseless Video: An Organizational Psychology Perspective on the "Identity Crises" of Corporate Television.

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Gutenko, Gregory

Corporate television suffers from at least two "identity crises": departmental isolation, and the lack of a legitimate identity for the corporate video product itself. Video departments are not usually viewed and accepted by the organizational whole as natural evolutions of a historically defined and behaviorally integrated system. The…

Gender Inequality and Disabled Inclusivity in Accounting Higher Education and the Accounting Profession during Financial Crises

Science.gov (United States)

Lodh, Suman; Nandy, Monomita

2017-01-01

In this article, the authors find that, during financial crises, the wage gap between female and male accounting professionals declines and gender inequality in higher education is affected. In addition, less support and lower wages for disabled accounting professionals demotivate disabled students in accounting higher education. Because of budget…

Role of Social Media and Networking in Volcanic Crises and Communication

Science.gov (United States)

Sennert, S.; Klemetti, E. W.; Bird, D. K.

2016-12-01

The growth of social media as a primary and often preferred news source has led to the rapid dissemination of information about volcanic eruptions and potential volcanic crises as they begin, evolve, and end. This information comes from a variety of sources: news organisations, emergency management personnel, individuals (both members of the public and official representatives), and volcano monitoring agencies. Once posted, this information is easily shared, increasing the reach to a much broader population than more traditional forms of media, such as radio and newspapers. The onset and popularity of social media as a vehicle for dissemination of eruption information points toward the need to systematically incorporate social media into the official channels that volcano observatories use to distribute activity statements, forecasts, and images. We explore two examples of projects that collect/disseminate information regarding volcanic crises and eruptive activity via social media sources; the Smithsonian/USGS Weekly Volcanic Activity Report (WVAR), which summarizes new and on-going volcanic activity globally and on a weekly basis, and Eruptions, a blog that discusses eruptions as well as other volcanic topics. Based on these experiences, recommendations are made to volcanic observatories in relation to the use of social media as a communication tool. These recommendations include: using social media as a two-way dialogue to communicate and receive information directly from the public and other sources; stating that the social media account is from an official source; and posting types of information that users want to see such as images, videos, and figures.

Corporate Social Responsibility and Social Media Crises - How to ride off a CSR-related shitstorm

DEFF Research Database (Denmark)

Agerdal-Hjermind, Annette; Schmeltz, Line

This paper aims to explore and offer insights into the phenomenon of social media crises in a CSR-related context by reflexively merging theoretical and case insights (Alvesson & Kärreman, 2007, p. 2011). The phenomenon and the components of a social media crisis are theoretically identified...... strategy and communicative skills during a CSR-related social media crisis....

Pulmonary fibrosis associated with psychotropic drug therapy: a case report

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Thornton Clare

2009-11-01

Full Text Available Abstract Introduction Sertraline and Risperidone are commonly used psychotropic drugs. Sertraline has previously been associated with eosinopilic pneumonia. Neither drug is recognised as a cause of diffuse fibrotic lung disease. Our report represents the first such case. Case Presentation We describe the case of a 33 year old Asian male with chronic schizophrenia who had been treated for three years with sertraline and risperidone. He presented to hospital in respiratory failure following a six month history of progressive breathlessness. High resolution CT scan demonstrated diffuse pulmonary fibrosis admixed with patchy areas of consolidation. Because the aetiology of this man's diffuse parenchymal lung disease remained unclear a surgical lung biopsy was undertaken. Histological assessment disclosed widespread fibrosis with marked eosinophillic infiltration and associated organising pneumonia - features all highly suggestive of drug induced lung disease. Following withdrawal of both sertraline and risperidone and initiation of corticosteroid therapy the patient's respiratory failure resolved and three years later he remains well albeit limited by breathlessness on heavy exertion. Conclusion Drug induced lung disease can be rapidly progressive and if drug exposure continues may result in respiratory failure and death. Prompt recognition is critical as drug withdrawal may result in marked resolution of disease. This case highlights sertraline and risperidone as drugs that may, in susceptible individuals, cause diffuse pulmonary fibrosis.

Crise tireotóxica - um relato de caso

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Mariana Fidelis Solla

2015-10-01

Full Text Available A crise tireotóxica (CT é a complicação mais grave dohipertireoidismo, caracterizada por um conjunto de sinais e sintomassecundários à hipersecreção aguda de hormônios tireoidianos. Contudo, adescompensação da tireoide até o estado de CT ainda não está bemestabelecida. Os fatores desencadeantes incluem: infecções, cirurgias,traumas, extrações dentárias, alterações glicêmicas, suspensão da medicaçãoanti-tireoidiana, parto e palpação vigorosa da tireóide . A CT é uma emergênciamédica que exige cuidados em unidade de tratamento intensivo (UTI. Odiagnóstico precoce é imprescindível para o êxito terapêutico e influidiretamente no prognóstico e sobrevida do paciente. Objetivos: Relatar o casoda paciente do Conjunto Hospitalar de Sorocaba (CHS que ficou sobrecuidados na UTI devido à CT que evolui para fibrilação atrial (FA etromboembolismo pulmonar (TEP, contribuindo para o meio acadêmico ecientífico. Metodologia: As informações contidas nesse trabalho foram obtidaspor meio de análise de prontuário e revisão de literatura. Relato de caso:Paciente de 25 anos, sexo feminino, deu entrada ao pronto atendimento doCHS com quadro de dispneia, palpitações intensas, ansiosa e com tremores deextremidades. A ectoscopia revelou paciente corada, hidratada, anictérica,acianótica, febril e anasarca evidente. O exame específico da tireóidedemonstrou glândula aumentada de tamanho, bócio difuso, sem nodulações àpalpação. Observou-se veias jugulares ingurgitadas e hepatomegalia. Àausculta verificou-se bulhas arrítimicas com hiperfonese de P2 e FC:214bpm.O ECG padrão de FA e sobrecarga de VE. Conclusão: O hipertiroidismo semtratamento clínico pode evoluir ,culminando com sinais e sintomas compatíveiscom crise tireotóxica. sendo necessários diagnóstico e tratamento precoces.

Crise econômica e retorno dos imigrantes brasileiros em Portugal

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Carolina Nunan

Full Text Available A crise econômica internacional desencadeada em 2008 produziu enormes efeitos sobre as migrações mundiais. Alguns estudos têm sido dedicados a esta temática. O objetivo deste artigo é refletir e discutir sobre a existência de um possível fluxo de retorno dos imigrantes brasileiros em Portugal ao país de origem. Os resultados desta investigação apontam para uma desaceleração do fluxo de entrada em Portugal, uma propensão significativa ao retorno, mas um volume efetivo de retorno inferior ao que seria teoricamente de esperar.

Evaluation and treatment of hypertensive crises in children

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Stein DR

2016-03-01

Full Text Available Deborah R Stein, Michael A Ferguson Division of Nephrology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA Abstract: Hypertensive crises in children are medical emergencies that must be identified, evaluated, and treated promptly and appropriately to prevent end-organ injury and even death. Treatment in the acute setting typically includes continuous intravenous antihypertensive medications with monitoring in the intensive care unit setting. Medications commonly used to treat severe hypertension have been poorly studied in children. Dosing guidelines are available, although few pediatric-specific trials have been conducted to facilitate evidence-based therapy. Regardless of what medication is used, blood pressure should be lowered gradually to allow for accommodation of autoregulatory mechanisms and to prevent cerebral ischemia. Determining the underlying cause of the blood pressure elevation may be helpful in guiding therapy. Keywords: hypertensive crisis, hypertensive urgency, hypertensive emergency, antihypertensive medications

Coping with Financial Crises: Latin American Answers to European Questions

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Eduardo A.Cavallo

2013-06-01

Full Text Available Europe faces challenges reminiscent of Latin American financial crises, namely unsustainable sovereign spreads, banking system distress, sudden stops in capital flows and growth rate collapse. The failure of recent liquidity support to normalize the situation suggests the need to refocus the policy debate on fundamentals: structural reform for growth and, where needed, restructuring to resolve banking crises and the debt overhang.  Latin America’s experience yields relevant policy lessons for Europe on all these fronts, tempered only by the slight exception that sharp real devaluation, which was key to spearheading recovery in Latin America, is unfeasible in the eurozone. Struggling eurozone countries are caught between a rock and a hard place, as the currency union imposes strict policy constraints while the reintroduction of national currencies under conditions of crisis would be catastrophic. Nevertheless, contemporary Europe stands a better chance of recovery because, in contrast with the Latin America experience, the European Union possesses greater avenues for international cooperation. With respect to financial support, a resourceful European Central Bank able to avoid chaotic adjustment by brute force is a decisive advantage of Europe relative to Latin America, which only had access to the weaker and less reliable IMF. Arguably, the limited nature of external support strongly contributed to the depth of Latin America’s great collapses. European cooperation can explore and exhaust alternatives to a euro exit to the benefit of all union members and, if dissolution becomes unavoidable, ensure amicable support to ease the transition. The path to success remains uncharted, however, and implementation of the necessary regional mechanisms will require innovation and political will. If the available means of cooperation are not used effectively, crisis countries in Europe may fare worse than those in Latin America.